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Sample records for anca-negative pauci-immune crescentic

  1. A Case of ANCA Negative Pauci-immune Crescentic Glomerulonephritis in Mixed Connective Tissue Disease

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    Neena Mampilly

    2015-04-01

    Full Text Available Pauci-immune crescentic glomerulonephritis (CrGN is one of the most common causes of rapidly progressive glomerulonephritis. The majority of patients with pauciimmune CrGN have circulating antineutrophil cytoplasmic autoantibodies (ANCA. Approximately 10% of systemic vasculitides patients test negative for ANCA. Majority of the ANCA negative pauciimmune CrGN described in the literature have not shown associations with connective tissue diseases. Only isolated case reports of associations with systemic lupus erythematosus and scleroderma have been described. We report the case of a 24 yr lady who was diagnosed to have a pauciimmune crescentic glomerulonephritis on renal biopsy, and was found to be ANCA negative. Subsequently her collagen profile revealed a mixed connective tissue disease, even though she did not have any other systemic manifestations of the disease at presentation. We presume that antiendothelial antibodies (AECA may have a role in the pathogenesis of the disease.

  2. Antineutrophil Cytoplasmic Antibody-negative Pauci-immune Crescentic Glomerulonephritis and Mantle-cell Lymphoma: A Case Report and Review of the Literature

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    J Wang*

    2014-12-01

    Full Text Available Mantle-cell lymphoma (MCL is an aggressive lymphoid neoplasm of non-Hodgkin's lymphoma (NHL. Crescentic glomerulonephritis associated with NHL has rarely been reported. In this report, we present a case of antineutrophil cytoplasmic antibody (ANCA-negative pauci-immune crescentic glomerulonephritis (GN, presenting with the coexistence of proteinuria, haematuria, progressive renal failure and MCL infiltration in the kidney, in the setting of newly-diagnosed MCL. Following the chemotherapy, there was a resolution of renal function. To the best of our knowledge, this is the first report of ANCA-negative pauci-immune crescentic GN and MCL. The pathophysiologic relationship between ANCA-negative pauci-immune crescentic GN and MCL should be investigated further.

  3. Relationship between serum AECA and clinical signatures of ANCA negative pauci-immune deposition type crescentic glomerulonephritis patients%ANCA阴性少免疫沉积型新月体性肾炎患者血清AECA与临床表现的关系研究

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    董向楠; 曹锐; 尹良红

    2016-01-01

    目的:探讨抗中性粒细胞胞浆抗体( ANCA)阴性少免疫沉积型新月体性肾炎患者血清抗内皮细胞抗体( AECA)表达情况,及其与临床表现的关系。方法:选取2010年至2015年在我院治疗的少免疫沉积型新月体性肾小球肾炎患者,其中ANCA阴性患者45例(观察组),ANCA阳性患者49例(对照组),采用Western blot检测各组患者血清AECA水平。结果:观察组平均年龄和伯明翰血管炎活动性评分(BVAS)分别为(41.08±9.43)岁和(15.03±3.82)分,明显低于对照组(P<0.05);观察组出现发热、关节痛的比例分别为26.67%和13.33%,明显低于对照组(P<0.05);观察组出现肾病综合征比例为48.89%,高于对照组( P<0.05);观察组血清 AECA阳性率为46.67%,明显低于对照组的81.63%( P<0.05);观察组 IgG-AECA共识别7种蛋白,而对照组共识别11种蛋白,其中观察组抗90 kD抗体阳性率为13.33%(6/45),明显低于对照组的51.02%(25/49)(P<0.05);观察组抗76 kD抗体阳性患者出现皮疹的比例为100%,明显高于阴性患者(P<0.05),抗200 kD抗体阳性患者BVAS评分为(18.02±2.51)分,明显高于阴性患者(P<0.05)。结论:ANCA阴性少免疫沉积型新月体性肾炎患者血清存在不同的AECA,可能与某些临床表现有关;ANCA阴性和阳性患者AECA有所不同,两者临床表现的差异可能与AECA的不同有关,需待进一步研究。%Objective:To investigate the expression of anti-endothelial cell antibodies(AECA) in patients serum with anti-neutrophil cytoplasmic antibody( ANCA) negative pauci-immune deposition type crescentic glomerulonephritis and its relationship with clinical signatures. Methods:We selected 94 pauci-immune deposition type crescentic glomerulonephritis patients from 2010 to 2015 treated in our hospital,45 of which with ANCA-negative( observation group) and 49 cases of ANCA

  4. PROBLEMS IN THE DIAGNOSIS AND TREATMENT OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS: IN THE FOCUS OF ANCA-NEGATIVE PAUCI-IMMUNE GLOMERULONEPHRITIS

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    T. V. Beketova

    2016-01-01

    Full Text Available One of the most common  causes of rapidly progressive glomerulonephritis (GN  is the so-called pauci-immune crescentic GN that is characterized  by no luminescence  in kidney tissue samples during immunofluorescence microscopy and by the hyperproduction of antineutrophil cytoplasmic antibodies (ANCA. At the same time, serum ANCAs are absent in a number of cases of pauci-immune GN. Based on their own experience, the authors present the clinical and morphological characteristics of patients with ANCA-negative  pauci-immune GN and analyze the data available in the literature.Subjects and methods. This retrospective study included 8 patients with ANCA-negative  pauci-immune GN,  who were followed up at two Russian centers (the Center of Nephrology and the Center of Rheumatology in 2011 to 2015. Results and discussion. According to our data, ANCAs are not detectable in 6% of the patients with ANCA-associated systemic vasculitis (SV with renal involvement and/or pauci-immune GN.  The mean age at onset of the disease in the ANCA-negative  patients was 50±18 years (range 19 to 74 years; the male/female  ratio was 1:1. Four (50% cases were diagnosed with microscopic polyangiitis; 2 cases had granulomatosis with polyangiitis; isolated renal injury was present in other 2 patients. The Birmingham SV activity index averaged 19.6±7.9.  Hematuria  was observed in all cases and it was massive in 4. The mean daily urinary protein level was 3.4±2.7 g; three (38% patients were observed to have nephrotic  syndrome. The blood creatinine  level averaged 704±405 μmol/l;  GN was characterized  by a rapidly progressive course in 6 (75% patients; hemodialysis was needed in 5. A morphological study of the kidney determined  crescents (in on an average of 52 glomeruli in the majority of cases and glomerulosclerosis in one patient. All the patients were observed to have varying degrees of interstitial fibrosis. Three (38% treated patients achieved

  5. Pauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis

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    Syed, Rafeel; Rehman, Amina; Valecha, Gautam; El-Sayegh, Suzanne

    2015-01-01

    Rapidly progressive glomerulonephritis (RPGN) is a syndrome signified by a precipitous loss of renal function, with features of glomerulonephritis including dysmorphic erythrocyturia and glomerular proteinuria. RPGN is associated with extensive crescent formation, and, thus, the clinical term RPGN is often used interchangeably with the pathologic term crescentic glomerulonephritis (CGN). From an immunopathologic standpoint, primary RPGN is divided into pauci-immune GN (PICG), anti-GBM GN, and immune complex GN. PICG, the most common etiology of primary RPGN, refers to a necrotizing glomerulonephritis with few or no immune deposits by immunofluorescence (IF) or electron microscopy (EM). In most patients, pauci-immune CGN is a component of a systemic small vessel vasculitis such as granulomatosis with polyangiitis (GPA). Approximately 90% of patients with PICG have circulating ANCA antibodies, leading to the nomenclature ANCA-associated vasculitis (AAV). Recent research has identified several other antibodies associated with PICG, which is now understood to be a complex spectrum of disease with considerable overlap in terms of clinical phenotype and outcomes. In addition, several genetic and environmental factors have recently been implicated in the pathogenesis of this disorder. With new prognostic classifications, enhanced understanding of immunopathologic mechanisms, and novel treatment paradigms, clinical and experimental interest in PICG remains high. PMID:26688808

  6. Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease

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    Supraja Yeturi

    2016-01-01

    Full Text Available Pauci-immune crescentic glomerulonephritis is commonly seen in ANCA-associated vasculitis but it is rarely seen during the course of other connective tissue diseases like lupus or Sjogren’s syndrome or MCTD. We report 3 cases of pauci-immune crescentic glomerulonephritis in patients with connective tissue disease other than vasculitis. We reviewed literature and made summary of previously reported cases of this rare entity. Clinical and laboratory features of these patients varied widely, but most of patients have met criteria for lupus. In this small population of patients there is no correlation with ANCAs. Most of the patients were treated with aggressive immunosuppression and did well if they were treated early in the course of their disease. One of our patients required renal transplant, but she presented late in the course of her disease, as evidenced by chronicity on her renal biopsy. Whether these patients are overlap of vasculitis and other connective tissue diseases or to be considered as a separate entity is yet to be described. Clinicians must be aware of these presentations because initial presentation can be severe.

  7. Pauci-immune crescentic glomerulonephritis in the Down's syndrome.

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    Cherif, Mejda; Hedri, Hafedh; Ounissi, Mondher; Gergah, Taher; Goucha, Rim; Barbouch, Samia; Abderrahim, Ezzedine; Maiz, Hedi Ben; Kheder, Adel

    2013-11-01

    Kidney disease is a rare complication in patients with the Down's syndrome. However, with increased survival, it appears that a growing number of these patients present with glomerulonephritis. Most cases have been reported as case reports and include lesions such as mesangiocapillary glomerulonephritis with hypo-complementemia, crescentic glomerulonephritis with anti-neutrophil cytoplasmic antibodies (ANCA), amyloidosis and immunotactoid glomerulopathy. We report the observation of a 38-year-old man with the Down's syndrome who presented with severe renal failure, proteinuria and microscopic hematuria evolving over two months. There was no history of congenital heart disease or urinary symptoms. Percutaneous renal biopsy revealed fibrous crescents, rupture of Bowman's capsule and peri-glomerular granuloma; there were no deposits on immunofluorescence study. Thoracic computerized tomography scan showed alveolar congestion. The patient tested negative for ANCA. At the time of reporting, the patient is on regular chronic hemodialysis. Our case illustrates a distinct entity that further expands the spectrum of renal disease known to occur in the Down's syndrome. Early detection of the renal disorders may prevent or slow down the progression.

  8. Native and recombinant proteins to analyze auto-antibodies to myeloperoxidase in pauci-immune crescentic glomerulonephritis

    NARCIS (Netherlands)

    Boomsma, MM; Stegeman, CA; Oost-Kort, WW; Kallenberg, CGM; Moguilevsky, N; Limburg, PC; Tervaert, JWC

    2001-01-01

    The prevalence of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) directed against myeloperoxidase (MPO) in pauci-immune necrotizing crescentic glomerulonephritis (NCGN) is dependent on the assay(s) used, We investigated the frequency of MPO-ANCA as detected by different assays for MPO-ANCA in a large

  9. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

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    Ryan Kunjal

    2016-01-01

    Full Text Available Antineutrophil cytoplasmic antibody (ANCA associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN. The diagnosis was consistent with granulomatosis with polyangiitis (GPA. Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management.

  10. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

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    Kunjal, Ryan; Makary, Raafat; Poenariu, Andreea

    2016-01-01

    Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN). The diagnosis was consistent with granulomatosis with polyangiitis (GPA). Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management. PMID:27293925

  11. Pauci-Immune Necrotizing and Crescentic Glomerulonephritis with Membranous Lupus Nephritis, Fifteen Years after Initial Diagnosis of Secondary Membranous Nephropathy

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    Ryan Burkhart

    2015-01-01

    Full Text Available Renal involvement in systemic lupus erythematosus (SLE is usually immune complex mediated and may have multiple different presentations. Pauci-immune necrotizing and crescentic glomerulonephritis (NCGN refers to extensive glomerular inflammation with few or no immune deposits that may result in rapid decline in renal function. We report a case of a 79-year-old Hispanic male with a history of secondary membranous nephropathy (diagnosed by renal biopsy 15 years previously who was admitted with acute kidney injury and active urinary sediment. P-ANCA titers and anti-myeloperoxidase antibodies were positive. The renal biopsy was diagnostic for NCGN superimposed on a secondary membranous nephropathy. A previous diagnosis of SLE based on American College of Rheumatology criteria was discovered via Veteran’s Administration records review after the completion of treatment for pauci-immune NCGN. ANCAs are detected in 20–31% of patients with SLE. There may be an association between SLE and ANCA seropositivity. In patients with lupus nephritis and biopsy findings of necrotizing and crescentic glomerulonephritis, without significant immune complex deposition, ANCA testing should be performed. In patients with secondary membranous nephropathy SLE should be excluded.

  12. PODOCYTE EXPRESSION OF MHC CLASS-I AND CLASS-II AND INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IN EXPERIMENTAL PAUCI-IMMUNE CRESCENTIC GLOMERULONEPHRITIS

    NARCIS (Netherlands)

    Coers, W; BROUWER, E.; Vos, J.TWM; CHAND, A.; Huitema, S.; Heeringa, Peter; Kallenberg, Cees; Weening, J.J.

    1994-01-01

    We examined immunopathological changes of podocytes in vivo which, based on in vitro studies, are thought to be relevant for the pathogenesis of renal diseases. We investigated the alterations of podocytes in local inflammation in a recently developed model of pauci-immune necrotizing crescentic glo

  13. The clinical and pathological characteristics of Chinese patients with pauci-immune crescent golmerulonephritis

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    唐政; 姚小丹; 胡伟新; 曾彩虹; 陈惠萍; 刘志红; 黎磊石

    2001-01-01

    目的对寡免疫复合物型新月体肾炎进行临床病理分析。方法采用病理检查包括:光镜检查、免疫病理分析、血清学检查、肾功能检查以及统计学分析。结果6400例非移植肾活检中发现24例寡免疫复合物型新月体肾炎(PICGN)患者,占肾活检总数的0.37%,占新月体肾炎总数的23.9%,其中女性16例,男性8例,平均年龄33岁。血管炎中微型多动脉炎 (33.3%)和结节性多动脉炎(8.3%)为常见继发病因。抗中性粒细胞胞浆抗体(ANCA)阳性率为52.2%。 临床上多表现为急进性肾功能减退(75.0%),发作性肉眼血尿发生率高(58.3%),高血压发生率为 45.8%,肾病综合症发生率为41.7%,25%患者出现少尿无尿症状。除贫血外,肾外表现较少。病理上血 管襻坏死(62.5%)、单核及中性粒细胞浸润(66.7%)及小血管炎等为常见的急性病变;然而,小球硬化 (45.8%)、小管萎缩(83.3%)、间质纤维化(75.0%)等慢性化病变也较严重。22例患者行免疫抑制治疗, 16例随访8-92个月,有4例肾功能在正常范围(<124μmol/L),8例行非透析保守治疗,仅4例进入终末 期肾功能衰竭需进行维持性血透析治疗。 结论免疫抑制冲击治疗是治疗PICGN的有效方法。%Objective To investigate the clinical and pathologicalcharacteristics of pauci-immune crescent glomerulo~nephritis (PICGN) in Chinese patients. Methods During 13 years (1985-1998), 6400 patients underwent non-transplanting renal biopsy. Twenty-four patients were diagnosed as PICGN. All clinical and laboratory data of these patients were collected from the patients' records and used for detailed analysis. The diagnosis is based on clinico-pathologic findings. Results Of the 24 patients, 16 were females and 8 were males, with median age of 33 years (ranged 10-76 years). Microscopic polyarteritis (MPA) (33.3%) and systemic vasculitis (8.3%) were the secondary

  14. Anti-neutrophil cytoplasmic antibody-associated Pauci-immune crescentic glomerulonephritis complicating Sjögren's syndrome.

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    Wang, Wei-Jei; Wu, Hau-Shin; Chu, Tzong-Shinn

    2011-07-01

    Sjögren's syndrome is a chronic autoimmune disease, characterized by specific autoimmune antibodies anti-Ro and anti-La, and it can involve multiple organs, such as the kidneys, lungs, muscles, and nervous system. The most common renal complication of Sjögren's syndrome is tubulointerstitial nephritis, and glomerulonephritis is relatively uncommon. We report the case of an 86-year-old man presenting with recurrent fever, poor appetite, decreased salivary secretion, and body weight loss. Laboratory investigation revealed that serum creatinine was 4.2 mg/dL, proteinuria was 3+, and there was microscopic hematuria. Positive perinuclear anti-neutrophil cytoplasmic antibody, anti-Ro, and anti-La antibodies were detected. Renal biopsy showed crescentic glomerulonephritis with scanty immune complex deposition. The patient was diagnosed with primary Sjögren's syndrome complicated with rapidly progressive glomerulonephritis with positive anti-neutrophil cytoplasmic antibody. Unlike the patients of other case reports, our patient's renal function did not recover after immunosuppressant treatment, and he finally received long-term hemodialysis. Pauci-immune glomerulonephritis is a rare renal complication of Sjögren's syndrome, and progress to renal failure in such patients is possible.

  15. Pauci-immune crescentic glomerulonephritis in the Down′s syndrome

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    Mejda Cherif

    2013-01-01

    Full Text Available Kidney disease is a rare complication in patients with the Down′s syndrome. However, with increased survival, it appears that a growing number of these patients present with glomerulonephritis. Most cases have been reported as case reports and include lesions such as mesangiocapillary glomerulonephritis with hypo-complementemia, crescentic glomerulonephritis with anti-neutrophil cytoplasmic antibodies (ANCA, amyloidosis and immunotactoid glomerulopathy. We report the observation of a 38-year-old man with the Down′s syndrome who presented with severe renal failure, proteinuria and microscopic hematuria evolving over two months. There was no history of congenital heart disease or urinary symptoms. Percutaneous renal biopsy revealed fibrous crescents, rupture of Bowman′s capsule and peri-glomerular granuloma; there were no deposits on immunofluorescence study. Thoracic computerized tomography scan showed alveolar congestion. The patient tested negative for ANCA. At the time of reporting, the patient is on regular chronic hemodialysis. Our case illustrates a distinct entity that further expands the spectrum of renal disease known to occur in the Down′s syndrome. Early detection of the renal disorders may prevent or slow down the progression.

  16. Pauci-immune necrotizing crescentic glomerulonephritis with crescentic and full moon extracapillary proliferation: clinico-pathologic correlation and follow-up study.

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    Unlu, Mehtat; Kiremitci, Saba; Ensari, Arzu; Ozluk, Yasemin; Kilicaslan, Isin; Ozdemir, Binnaz Handan; Ates, Deniz; Ertoy Baydar, Dilek; Gonul, Ipek Isik; Memis, Leyla; Sarsik, Banu; Sen, Sait; Akkaya, Bahar; Orhan, Diclehan; Gonlusen, Gulfiliz; Ellidokuz, Hulya; Ada, Sibel; Cavdar, Caner; Akagun, Tulin; Kamali, Sevil; Aksu, Kenan; Yazisiz, Veli; Paydas, Saime; Soylu, Alper; Sarioglu, Sulen

    2013-02-15

    The prognostic value of the type and extent of extracapillary proliferation (ECP) in pauci-immune necrotizing crescentic glomerulonephitis (PIGN) was evaluated in this study. In 141 PIGN cases, all glomeruli with ECP were grouped according to type (cellular, fibrocellular and fibrous) and extent of the lesions in Bowman's space; (segmental, semicircumferential and circumferential, which might be termed full moon-FM). Cases with cellular and fibrous lesions involving ≥ 50% of glomeruli with ECP were classified as cellular and fibrous groups, respectively, while the remaining cases were classified as fibrocellular. Cases with segmental and circumferential (FM glomerulus) lesions involving ≥ 50% of glomeruli with ECP were classified as ECPI and ECPIII (FM) groups, respectively, while the rest were classified as ECPII. All the cases were classified according to Berden et al. Significant results were only nearly obtained for the FM group, including the need for dialysis. The Cox regression model revealed a 2.6-fold risk for FM cases regarding dialysis requirement. We propose that the percentage of FM glomeruli should be noted in the pathology report, and cases with more than 50% of FM glomeruli (FM group) should be identified in the group with increased risk of dialysis requirement. Our series also suggests that classification according to Berden et al. is of clinical relevance. Copyright © 2012 Elsevier GmbH. All rights reserved.

  17. Renal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study

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    Ranjana W Minz

    2012-01-01

    Full Text Available Context: The need to perform reporting of renal biopsies of antineutrophil cytoplasmic antibodies (ANCA-associated vasculitides in a more uniform manner required relook at our eight-year data. Aims: To document detailed renal histopathology of pauci-immune rapidly progressive glomerulonephritis (RPGN and also to seek any significant differences in renal histology of C-ANCA-positive, P-ANCA-positive, and ANCA-negative patients. Materials and Methods: A detailed analysis of the histopathologic features of renal biopsies of 48 patients in whom a diagnosis of pauci-immune glomerulonephritis was concluded on renal biopsy and who presented clinically as rapidly progressive renal failure was done. Statistical Analysis Used: One-way ANOVA and Pearson Chi square tests. Results: Compared with ANCA +ve patients, the ANCA -ve patients were much younger (46.85 ± 16.12 years vs 34.28±15.94 years. No significant differences were found between renal lesions of C-ANCA, P-ANCA, and ANCA-negative patients, except for diffuse tubular atrophy which was more severe and more frequently present with P-ANCA positivity (P value=0.013. Conclusions: Pauci-immune RPGN (irrespective of ANCA status is a relatively rare disorder in patients who are undergoing the renal biopsy at our institute, constituting 2% of all renal biopsies submitted. It is mandatory to have ANCA serology status during reporting of a kidney biopsy showing pauci-immune crescentic or necrotizing glomerulonephritis. Also, if a uniform reporting strategy is followed throughout the country, the studies from this vast country will be comparable.

  18. Poor Renal Outcome of Antineutrophil Cytoplasmic Antibody Negative Pauci-immune Glomerulonephritis in Taiwanese

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    Peir-Haur Hung

    2006-01-01

    Conclusion: This study illustrates the necessity for pathologic diagnosis of pauci-immune GN despite ANCA negativity. The poor prognosis associated with ANCA negativity in this study may be partly due to delayed diagnosis since these patients frequently lacked systemic involvement.

  19. Pauci-immune lupus nephritis: possibility or co-incidence?

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    Cansu, Döndü Üsküdar; Temiz, Gökhan; Açıkalın, Mustafa F.; Korkmaz, Cengiz

    2017-01-01

    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized with immune complex formation and renal involvement of lupus and may include several kinds of pathological conditions, but mostly, it is associated with immune complex-induced glomerular disease. Pauci-immune lupus nephritis is a very rare condition. We describe a 45-year-old female patient with pauci-immune crescentic necrotizing lupus nephritis and briefly discuss the possible mechanism and pathogenesis.

  20. Pauci-immune necrotizing glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Sanders, Jan S F; Stegeman, Coen A; Kallenberg, Cees G M

    2010-01-01

    Pauci-immune necrotizing glomerulonephritis is the most frequent cause of rapidly progressive glomerulonephritis and, in most cases, is associated with antineutrophil cytoplasmic antibodies (ANCA). It is either the renal manifestation of Wegener's granulomatosis, microscopic polyangiitis of Churg-St

  1. A historical study of American patients with anti-neutrophil cytoplasmic antibody negative pauci-immune glomerulonephritis.

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    Shah, Shivani; Havill, John; Rahman, M Hafizur; Geetha, Duvuru

    2016-04-01

    Anti-neutrophil cytoplasmic antibodies (ANCA) play an important role in the pathogenesis of ANCA-associated vasculitis. The lack of ANCA antibodies may indicate a variation in clinical presentation and outcomes of this disease. We identified 74 adult patients between 1995 and 2009 with the diagnosis of pauci-immune glomerulonephritis. Demographics, histological features, and treatment outcomes were compared between ANCA-positive and ANCA-negative patients. These factors were correlated with renal function at presentation and follow-up. Of the 74 patients, 57 were ANCA-positive, and 17 were ANCA-negative. Demographics and mean Birmingham Vasculitis Activity Score were similar between ANCA-negative and ANCA-positive patients at presentation. Renal function was significantly worse at presentation in the ANCA-negative patients (eGFR 16.59 vs. 31.89 ml/min/1.73 m(2), p = 0.03). Patients in the ANCA-negative group had a significantly higher interstitial fibrosis score compared to the ANCA-positive group (2.1 vs.1.6, p = 0.04). The median time to remission was shorter in the ANCA-negative patients (51 vs. 78 days, p = 0.01). Long-term renal function and 1-year patient and renal survival were similar between ANCA-negative and ANCA-positive patients. Baseline eGFR, percentage of normal glomeruli, glomerular sclerosis, and tubulointerstitial scarring predicted eGFR at 1 year in both groups similarly. This is the first historical review of American patients with pauci-immune glomerulonephritis, comparing patients with ANCA-negative and ANCA-positive serology. Although ANCA-negative patients present with lower eGFR and more interstitial fibrosis, 1-year and long-term outcomes in both groups are similar.

  2. Bartonella Endocarditis and Pauci-Immune Glomerulonephritis

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    Raybould, Jillian E.; Raybould, Alison L.; Morales, Megan K.; Zaheer, Misbah; Lipkowitz, Michael S.; Timpone, Joseph G.; Kumar, Princy N.

    2016-01-01

    Abstract Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement. Although a pauci-immune pattern is a frequent finding in infectious endocarditis–associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti–neutrophil cytoplasmic antibody (ANCA) positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis. Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone. PMID:27885316

  3. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis

    DEFF Research Database (Denmark)

    Kain, R.; Exner, M.; Brandes, R.;

    2008-01-01

    in almost all individuals with FNGN. Consequently, its prevalence is nearly twice that of the classical ANCAs that recognize myeloperoxidase or proteinase-3. Furthermore, antibodies to LAMP-2 cause pauci-immune FNGN when injected into rats, and a monoclonal antibody to human LAMP-2 (H4B4) induces apoptosis...... of human microvascular endothelium in vitro. The autoantibodies in individuals with pauci-immune FNGN commonly recognize a human LAMP-2 epitope (designated P41-49) with 100% homology to the bacterial adhesin FimH, with which they cross-react. Rats immunized with Ill develop pauci-immune FNGN and also...... develop antibodies to rat and human LAMP-2. Finally, we show that infections with fimbriated pathogens are common before the onset of FNGN. Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN....

  4. Antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding

    Directory of Open Access Journals (Sweden)

    Miyeon Kim

    2015-09-01

    Full Text Available A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45th hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.

  5. Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis.

    Science.gov (United States)

    Veronese, F V; Dode, R S O; Friderichs, M; Thomé, G G; da Silva, D R; Schaefer, P G; Sebben, V C; Nicolella, A R; Barros, E J G

    2016-01-01

    Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs) and other autoantibodies. Here we report the case of a 49-year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs. His laboratory tests on admission showed serum creatinine of 4.56 mg/dL, white blood count 3,800/μL, hemoglobin 7.3 g/dL, urinalysis with 51 white blood cells/μL and 960 red blood cells/μL, and urine protein-to-creatinine ratio 1.20. Serum ANCA testing was positive (>1:320), as well as serum anti-myeloperoxidase and anti-proteinase 3 antibodies. Urine toxicology screen was positive for cocaine and levamisole, with 62.8% of cocaine, 32.2% of levamisole, and 5% of an unidentified substance. Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively. The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1.97 mg/dL, white blood cell count 7,420/μL, and hemoglobin level 10.8 g/dL. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.

  6. Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis

    Directory of Open Access Journals (Sweden)

    F.V. Veronese

    2016-01-01

    Full Text Available Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs and other autoantibodies. Here we report the case of a 49-year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs. His laboratory tests on admission showed serum creatinine of 4.56 mg/dL, white blood count 3,800/μL, hemoglobin 7.3 g/dL, urinalysis with 51 white blood cells/μL and 960 red blood cells/μL, and urine protein-to-creatinine ratio 1.20. Serum ANCA testing was positive (>1:320, as well as serum anti-myeloperoxidase and anti-proteinase 3 antibodies. Urine toxicology screen was positive for cocaine and levamisole, with 62.8% of cocaine, 32.2% of levamisole, and 5% of an unidentified substance. Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively. The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1.97 mg/dL, white blood cell count 7,420/μL, and hemoglobin level 10.8 g/dL. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.

  7. Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis

    NARCIS (Netherlands)

    Xing, Guang-qun; Chen, Min; Liu, Gang; Heeringa, Peter; Zhang, Jun-jun; Zheng, Xin; Jie, E.; Kallenberg, Cees G. M.; Zhao, Ming-hui

    2009-01-01

    This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis. Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necr

  8. Mechanisms of vasculitis : How pauci-immune is ANCA-associated renal vasculitis?

    NARCIS (Netherlands)

    van Paassen, P.; Tervaert, J. W. Cohen; Heeringa, P.

    2007-01-01

    Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative la

  9. Mechanisms of vasculitis : How pauci-immune is ANCA-associated renal vasculitis?

    NARCIS (Netherlands)

    van Paassen, P.; Tervaert, J. W. Cohen; Heeringa, P.

    2007-01-01

    Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative

  10. Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib.

    Science.gov (United States)

    Grundmann, Franziska; Witthus, Marco; Göbel, Heike; Kisner, Tuelay; Siewert, Rainer; Benzing, Thomas; Kurschat, Christine E

    2013-06-01

    Extracapillary-proliferative glomerulonephritis is a rare complication of multiple myeloma. Partial remission of kidney involvement with cyclophosphamide therapy has previously been described. We report the case of a 60-year-old male patient diagnosed with rapidly progressive glomerulonephritis associated with IgG kappa monoclonal gammopathy. His kidney biopsy revealed pauci-immune extracapillary-proliferative glomerulonephritis without cryoglobulinaemia. Treatment with the proteasome inhibitor bortezomib induced rapid clinical and histological remission of his kidney disease. The patient's renal function remained stable on bortezomib maintenance therapy. Our findings suggest that bortezomib is a promising therapeutic approach to ameliorate severe kidney damage in monoclonal gammopathy- and myeloma-associated pauci-immune extracapillary-proliferative glomerulonephritis.

  11. Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib

    OpenAIRE

    2013-01-01

    Extracapillary-proliferative glomerulonephritis is a rare complication of multiple myeloma. Partial remission of kidney involvement with cyclophosphamide therapy has previously been described. We report the case of a 60-year-old male patient diagnosed with rapidly progressive glomerulonephritis associated with IgG kappa monoclonal gammopathy. His kidney biopsy revealed pauci-immune extracapillary-proliferative glomerulonephritis without cryoglobulinaemia. Treatment with the proteasome inhibit...

  12. Pauci-Immune Glomerulonephritis in Individuals With Disease Associated With Levamisole-Adulterated Cocaine

    Science.gov (United States)

    Carlson, Adam Q.; Tuot, Delphine S.; Jen, Kuang-Yu; Butcher, Brad; Graf, Jonathan; Sam, Ramin; Imboden, John B.

    2014-01-01

    Abstract Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus anticoagulants, and very high titers of antineutrophil cytoplasmic antibodies. Two recent case reports suggest that levamisole-adulterated cocaine may also lead to renal disease in the form of pauci-immune glomerulonephritis. To explore this possibility, we reviewed cases of pauci-immune glomerulonephritis between 2010 and 2012 at an inner city safety net hospital where the prevalence of levamisole in the cocaine supply is known to be high. We identified 3 female patients and 1 male patient who had biopsy-proven pauci-immune glomerulonephritis, used cocaine, and had serologic abnormalities characteristic of levamisole-induced autoimmunity. Each also had some other form of clinical disease known to be associated with levamisole, either neutropenia or cutaneous manifestations. One patient had diffuse alveolar hemorrhage. Three of the 4 patients were treated with short courses of prednisone and cyclophosphamide, 2 of whom experienced stable long-term improvement in their renal function despite ongoing cocaine use. The remaining 2 patients developed end-stage renal disease and became dialysis-dependent. This report supports emerging concern of more wide spread organ toxicity associated with the use of levamisole-adulterated cocaine. PMID:25398064

  13. Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature.

    Science.gov (United States)

    Raybould, Jillian E; Raybould, Alison L; Morales, Megan K; Zaheer, Misbah; Lipkowitz, Michael S; Timpone, Joseph G; Kumar, Princy N

    2016-09-01

    Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement. Although a pauci-immune pattern is a frequent finding in infectious endocarditis-associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti-neutrophil cytoplasmic antibody (ANCA) positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis. Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone.

  14. ANCA-negative limited Wegener′s granulomatosis

    Directory of Open Access Journals (Sweden)

    Ghosh A

    2004-03-01

    Full Text Available A 26-year-old man presented with epistaxis, nasal obstruction and a subcutaneous swelling over the left malar region with radiological evidence of a mass in the right nasal cavity. Histology of the lesions showed necrotizing granuloma with evidence of vasculitis. There was no other systemic involvement and the patient was ANCA-negative. Excellent response to systemic steroid and cyclophosphamide therapy was noted.

  15. Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Turki Al-Hussain

    2017-01-01

    Full Text Available A series of 78 cases of glomerulonephritis (GN, in which renal biopsy revealed changes of GN associated with crescent formation, were reviewed. Renal pathology findings were correlated with clinical features including patient’s age, renal function, and serologic findings. In most of the cases (71.8%, the crescents were due to immune complex-mediated GN. This was followed by pauci-immune GN (20.5% and anti-glomerular basement membrane antibody (GBM GN (7.7%. The percentage of glomeruli with crescents was the highest in cases of anti-GBM disease (mean of 93.3%, followed by pauci-immune GBM (mean of 48.2% and immune complex GN (30.9%. In cases with the pauci- immune GN, there were additional features of glomerular injury including fibrinoid necrosis, disruption of the GBM, and rupture of Bowman’s capsule. These changes were generally more pronounced in a subset of pauci-immune GN associated with serum elevation of antineutrophil cytoplasmic antibody (c-ANCA. In biopsies from patient with immune complex disease, systemic lupus erythematosus was the most common cause of crescentic GN.

  16. Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases.

    Science.gov (United States)

    Carlson, Adam Q; Tuot, Delphine S; Jen, Kuang-Yu; Butcher, Brad; Graf, Jonathan; Sam, Ramin; Imboden, John B

    2014-10-01

    Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus anticoagulants, and very high titers of antineutrophil cytoplasmic antibodies. Two recent case reports suggest that levamisole-adulterated cocaine may also lead to renal disease in the form of pauci-immune glomerulonephritis. To explore this possibility, we reviewed cases of pauci-immune glomerulonephritis between 2010 and 2012 at an inner city safety net hospital where the prevalence of levamisole in the cocaine supply is known to be high. We identified 3 female patients and 1 male patient who had biopsy-proven pauci-immune glomerulonephritis, used cocaine, and had serologic abnormalities characteristic of levamisole-induced autoimmunity. Each also had some other form of clinical disease known to be associated with levamisole, either neutropenia or cutaneous manifestations. One patient had diffuse alveolar hemorrhage. Three of the 4 patients were treated with short courses of prednisone and cyclophosphamide, 2 of whom experienced stable long-term improvement in their renal function despite ongoing cocaine use. The remaining 2 patients developed end-stage renal disease and became dialysis-dependent. This report supports emerging concern of more wide spread organ toxicity associated with the use of levamisole-adulterated cocaine.

  17. Crescentic glomerulonephritis: A clinical and histomorphological analysis of 46 cases

    Directory of Open Access Journals (Sweden)

    Ruchika Gupta

    2011-01-01

    Full Text Available Background: Crescentic glomerulonephritis (CrGN, defined as crescents involving more than 50% of the glomeruli, includes pauci-immune, immune complex-mediated and anti-glomerular basement membrane disease. Objectives: The present study was aimed at evaluating the various clinical, biochemical and histological parameters in CrGN with respect to these categories and clinical outcome. Materials and Methods: Renal biopsies diagnosed as CrGN between Jan 2008 and Feb 2010 were included. Clinical and laboratory parameters were retrieved along with the therapeutic approach and clinical outcome, wherever available. Renal biopsy slides were evaluated for various glomerular, tubulo-interstitial and arteriolar features. Appropriate statistical tests were applied for significance. Results: A total of 46 cases of CrGN were included; majority (71.7% of cases were pauci-immune (PI while 28.3% were immune complex-mediated (IC. Among clinical features, gender ratio was significantly different between PI and IC groups (P = 0.006. The various histological parameters, including proportion of cellular crescents, tuft necrosis and Bowman′s capsule rupture, were similar in both the groups. Four unusual associations, including idiopathic membranoproliferative glomerulonephritis (MPGN, multibacillary leprosy, acute lymphoblastic leukemia and C1q nephropathy were detected. Adequate follow-up information was available in 21 (46% of the patients. Of these, 11 (52.4% were dialysis-dependent at the last follow-up. Adult patients required renal replacement therapy more frequently than pediatric cases (P = 0.05. Presence of arteriolar fibrinoid necrosis also showed association with poor clinical outcome (P = 0.05. Conclusions: Crescentic glomerulonephritis remains one of the main causes of acute renal failure with histological diagnosis. Immunohistologic examination is essential for accurate classification into one of the three categories. This condition should be considered

  18. Necrotizing and crescentic glomerulonephritis with membranous nephropathy in a patient exposed to levamisole-adulterated cocaine.

    Science.gov (United States)

    Carrara, Camillo; Emili, Stefano; Lin, Mercury; Alpers, Charles E

    2016-04-01

    Levamisole is an antihelminthic agent widely used as an adulterant of illicit cocaine recently implicated as a cause of antineutrophil cytoplasmic antibody (ANCA)-associated microscopic polyangiitis in cocaine abusers. An isolated case of membranous nephropathy (MN) associated with levamisole exposure has also been reported. We report the first case, to our knowledge, of a patient with both microscopic polyangiitis manifest as a pauci-immune necrotizing and crescentic glomerulonephritis and concurrent MN in the setting of chronic cocaine abuse and presumed levamisole exposure, raising the hypothesis that levamisole was the causative agent in the development of this rare dual glomerulopathy.

  19. Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy

    Science.gov (United States)

    Gadde, Shilpa; Lee, Belinda; Kidd, Laura; Zhang, Rubin

    2016-01-01

    Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis. PMID:27872837

  20. Membranous nephropathy with crescents associated with levamisole-induced MPO-ANCA vasculitis.

    Science.gov (United States)

    Moinuddin, Irfan; Madhrira, Machaiah; Bracamonte, Erika; Thajudeen, Bijin; Sussman, Amy

    2016-07-01

    ANCA-associated vasculitis (AAV) is the most common cause of crescentic rapidly progressive glomerulonephritis (GN). Levamisole used as an adulterant in cocaine is increasingly recognized as a cause of AAV. We report the case of a 50 year old woman with atypical anti-MPO AAV associated with cocaine use and exposure to levamisole. In addition to the clinical and pathologic findings of crescentic GN, the patient also had biopsy evidence of secondary membranous nephropathy (MN). Although AAV and MN have been reported previously in the same patient and both have been induced by drug exposures, this is the first report of MN in a patient with AAV likely induced by levamisole. We suggest that MPO can cause both pauci-immune vasculitis and secondary membranous nephropathy in some cases, as in cases of levamisole-adulterated cocaine use.

  1. Clinical presentation of Churg-Strauss syndrome in children. A 12-year-old-boy with ANCA-negative Churg-Strauss syndrome.

    NARCIS (Netherlands)

    F.G.E.M. Razenberg (Femke); J.W.C.M. Heynens (Jan); G. Jan de Vries (Geeuwke); L. Duijts (Liesbeth); J.C. de Jongste (Johan); J. de Blic; P.P.R. Rosias (Philippe)

    2012-01-01

    textabstractChurg-Strauss syndrome is an uncommon multisystem disorder characterized by asthma, eosinophilia and vasculitis. We report on a 12-year-old boy with asthma and deterioration of his general condition, who was eventually diagnosed with an ANCA-negative Churg-Strauss syndrome. The propositu

  2. Crescent Wars

    Science.gov (United States)

    Schaefer, B. E.

    1997-12-01

    Historically, many calendars are based on lunar months, where the start of the month is based on the sighting of the thin crescent Moon in the evening twilight. Yet the problem of predicting (or postdicting) crescent visibility is a difficult task. In modern times, the Islamic calendar is used by more than a billion people, while its utility is abridged by the ambiguities in knowing the dates. As such, I would claim that crescent visibility is the single (nontrivial) astronomical problem that affects the most people. LeRoy Doggett spearheaded an effort to place crescent visibility on a firm observational basis by organizing five Moonwatch campaigns involving thousands of observers spread out across North America. His idea was to collect large numbers of actual observations for direct confrontation with models, and to measure the error rates. This talk will report on his results. The application of the results are broad; frequently in areas of scholarly, historical, social, or military disputes. For example, lunar visibility is vital for dating the Crucifixion, a task contentious among Biblical scholars. Another example is in testing the historicity of the claimed lunar impact reported by Gervase of Canterbury. The meeting will be held in the middle of the Islamic holy month of Ramadan, while in the past two decades the majority of Ramadans have been started based on reported crescent sightings before the time of New Moon.

  3. Anti-neutrophil cytoplasmic antibody negative crescentic paucimmune glomerulonephritis in a case of scleroderma with systemic lupus erythematosus overlap

    Directory of Open Access Journals (Sweden)

    Rohit Tewari

    2016-01-01

    Full Text Available Renal Involvement in scleroderma is a known problem and the manifestations are well described. Renal involvement in systemic lupus erythematosus (SLE is also well known. However, in scleroderma and SLE overlap syndrome, the renal findings may vary being a combination of features of immune complex mediated glomerulonephritis as well as thrombotic microangiopathy. We report a case in which the renal manifestation in such a situation was of a focal necrotising pauci-immune glomerulonephritis with crescents, anti-neutrophil cytoplasmic antibody negative. To the best of our knowledge, such manifestations have not been described before. Renal dysfunction in a normotensive setting in such a case should direct one towards evaluation for other causes and should prompt a kidney biopsy. This would be valuable in delineating the pathological process in the kidney and would help in guiding therapy.

  4. MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report

    Directory of Open Access Journals (Sweden)

    Morizane Ryuji

    2012-06-01

    Full Text Available Abstract Background Antineutrophil cytoplasmic antibody (ANCA-associated crescentic glomerulonephritis (CGN is a major cause of rapidly progressive glomerulonephritis (RPGN. ANCA-associated CGN is generally classified into pauci-immune RPGN, in which there are few or no immune complexes. Case Presentation A 78-year-old man presented with RPGN after a 7-year course of chronic proteinuria and hematuria with stable renal function. A blood examination showed a high titer of myeloperoxidase (MPO-ANCA. A renal biopsy showed crescentic glomerulonephritis with abundant subepithelial, intramenbranous and subendothelial deposits by electron microscopy, leading to the diagnosis of ANCA-associated CGN superimposed on type 3 membranoproliferative glomerulonephritis (MPGN. Conclusions This case is unique in that type 3 MPGN and MPO-ANCA-associated CGN coexisted, and no similar case has been reported to date. Because ANCA-associated CGN has a predilection for elderly individuals and primary type 3 MPGN is rarely seen in this age group, coincidental existence appears less likely. This case may confer valuable information regarding the link between immune complex and ANCA-associated CGN.

  5. Isolated pauci-immune pulmonary capillaritis

    Directory of Open Access Journals (Sweden)

    Ashok Kumar Mehrotra

    2015-01-01

    Full Text Available A young house wife presented with low grade fever, cough, haemoptysis and SOB of unknown aetiology for 40 days duration. Respiratory system examination revealed diffuse crepts and rhonchi. Other organ system examination did not reveal any abnormality. X-ray chest PA view and CT thorax showed diffuse bilateral necrotising nodular lesions of various sizes with small pleural effusion. She also had low resting oxygen saturation with falling haematocrit. Her Serum was week positive for p-ANCA and negative for MPO-ANCA. Bronchoscopy revealed continuous bloody aspirates. We could not isolate any organisms in any of the specimens from her and she was unresponsive to any of the antibiotics either. Based on the clinical, laboratory data, radiological features and positive outcome to pulse therapy of methylprednisolone and cyclophosphamide, she was diagnosed as a case of IPIPC.

  6. Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries.

    Science.gov (United States)

    Dewan, Deepak; Gulati, Sanjeev; Sharma, Raj K; Prasad, Narayan; Jain, Manoj; Gupta, Amit; Kumar, Alok

    2008-03-01

    Crescentic glomerulonephritis (CsGN) is an uncommon entity in children. This prospective study was conducted to evaluate the aetiology, clinical spectrum and outcome in children with crescentic glomerulonephritis. The single-centre prospective study comprised of 22 children with biopsy proven CsGN who had been referred to our institute over the period January 2000 to December 2005. These patients were subjected to detailed clinical and biochemical examinations. The diagnosis of underlying renal disease was based on various criteria, including the clinical picture, serology and histopathology. The patients received intravenous methyl prednisolone, oral steroid treatment, and oral cyclophosphamide with or without plasmapheresis. All patients received supportive care, including control of hypertension and oedema and supportive management of renal insufficiency. During this 5-year period, CsGN accounted for 5.1% of all biopsies done in children. The mean age was 12.27 years (range 4 years to 18 years). There were eight girls and 14 boys. The mean duration of symptoms prior to referral was 2.47 months (range 5 days to 21 months). Aetiology was immune complex in 19 cases, anti-glomerular basement membrane (anti-GBM) antibody disease in two cases and pauci-immune (Wegener's granulomatosis) in one case. The percentage of crescents ranged from 50% to 100% (mean 70.6%). Twenty-one out of 22 (95.5%) children in our series had hypertension at presentation that required treatment with antihypertensive medications. The serum creatinine level at presentation ranged from 1.5 mg/dl to 11.4 mg/dl (mean 5.5 mg/dl). Of the 22 children, two were lost to follow-up, while the mean follow-up period of the rest of the 20 children was 8.13 months (range 1 month to 43 months). At the last follow-up of the 22 children, ten had stage 5 chronic kidney disease (CKD) and three had stage 4 CKD, while seven children had a calculated glomerular filtration rate (GFR) of >60 ml/min per 1.73 m(2) body

  7. Crescentic glomerulonephritis in children.

    Science.gov (United States)

    Jardim, H M; Leake, J; Risdon, R A; Barratt, T M; Dillon, M J

    1992-05-01

    Data on patients with crescentic glomerulonephritis (greater than 50% glomeruli with crescents), referred to the Hospital for Sick Children during the past 13 years, were reviewed. Thirty patients (13 male, 17 female) aged 3.7-15.7 years (mean 9.5) were evaluated. Initial clinical features included: oedema (24/30), hypertension (19/30), gross haematuria (15/30), oliguria (15/30) and a decreased glomerular filtration rate (GFR less than 30 ml/min per 1.73 m2) (22/30). Henoch-Schönlein purpura was present in 9 patients, microscopic polyarteritis in 3, polyarteritis nodosa in 1, Wegener's granulomatosis in 1, systemic lupus erythematosus in 1, post-streptococcal glomerulonephritis in 2, mesangiocapillary glomerulonephritis in 7, anti-glomerular basement membrane glomerulonephritis in 2, and 4 were idiopathic. In 10 patients 50%-79% of glomeruli were affected by crescentic changes (group 1) and in the remaining 20, 80% or more (group 2). The crescents were cellular, fibrocellular or fibrous, and the degree of sclerosis was assessed. Patients in both groups were treated with plasma exchange, corticosteroids, anticoagulants, cyclophosphamide and azathioprine in different combinations. On follow-up, 3 patients were dead, 1 was lost to follow-up, 12 were on dialysis/transplant programmes, 4 had a GFR of less than 30 and 10 a GFR of more than 30 ml/min per 1.73 m2. In our experience, 50% progressed to end-stage renal failure. The interval between disease onset and start of treatment was a prognostic factor for outcome. Fibrous crescents were associated with a worse outcome than fibrocellular crescents (P less than 0.05). Outcome was not, however, related to the percentage of glomeruli affected (P greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Crescent Lake Wilderness Reference Sheet

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Reference sheet includes information about Crescent Lake National Wildlife Refuge, and results of the public hearing for Crescent Lake Wilderness Proposal.

  9. Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience.

    Science.gov (United States)

    Rampelli, S K; Rajesh, N G; Srinivas, B H; Harichandra Kumar, K T; Swaminathan, R P; Priyamvada, P S

    2016-01-01

    There is limited data on the etiology, clinical and histopathological spectrum and outcomes of crescentic glomerulonephritis (CrGN) in adult Indian population. This prospective study was done to evaluate the etiology, clinicohistological patterns and predictors of outcome of CrGN in South Indian population. All the patients received standard protocol based immunosuppression in addition to supportive care. Immune-complex glomerulonephritis (ICGN) was the most common etiology (n = 31; 77.5%) followed by pauci-immune glomerulonephritis (PauciGN; n = 8; 20%) and anti-glomerular basement membrane disease (n = 1; 2.5%). The most common etiology of ICGN was IgA nephropathy (n = 11; 27.5%) followed by lupus nephritis (n = 7; 17.5%) and post-infectious glomerulonephritis (PIGN) (n = 7; 17.5%). The patients with PauciGN were significantly older compared to those with ICGN (44.5 ± 15 years vs. 31.8 ± 11 years; P = 0.01). The patients with PauciGN presented with significantly higher serum creatinine (9.7 ± 4.4 vs. 6.6 ± 3.3 mg/dl; P = 0.03). The histopathologic parameters of ICGN and PauciGN were comparable except for a higher proportion of sclerosed glomeruli in ICGN. At the end of 3 months follow-up, only two patients went into complete remission (5.4%). Majority of the patients had end-stage renal failure (48.6%) and were dialysis dependent and seven patients (18.9%) expired. There was no signifi difference in the renal survival (10.9 ± 1.9 vs. 9.6 ± 3.3 months) or patient survival (17.5 ± 2.1 vs. 17.3 ± 4.3 months). The parameters associated with adverse outcomes at 3 months were hypertension (odds ratio [OR]: 0.58; confidence interval [CI]: 0.36-0.94), need for renal replacement therapy (OR: 0.19; CI: 0.04-0.9), serum creatinine at admission (P = 0.019), estimated glomerular filtration rate (P = 0.022) and percentage of fibrocellular crescents (P = 0.022).

  10. Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience

    Directory of Open Access Journals (Sweden)

    S K Rampelli

    2016-01-01

    Full Text Available There is limited data on the etiology, clinical and histopathological spectrum and outcomes of crescentic glomerulonephritis (CrGN in adult Indian population. This prospective study was done to evaluate the etiology, clinicohistological patterns and predictors of outcome of CrGN in South Indian population. All the patients received standard protocol based immunosuppression in addition to supportive care. Immune-complex glomerulonephritis (ICGN was the most common etiology (n = 31; 77.5% followed by pauci-immune glomerulonephritis (PauciGN; n = 8; 20% and anti-glomerular basement membrane disease (n = 1; 2.5%. The most common etiology of ICGN was IgA nephropathy (n = 11; 27.5% followed by lupus nephritis (n = 7; 17.5% and post-infectious glomerulonephritis (PIGN (n = 7; 17.5%. The patients with PauciGN were significantly older compared to those with ICGN (44.5 ± 15 years vs. 31.8 ± 11 years; P = 0.01. The patients with PauciGN presented with significantly higher serum creatinine (9.7 ± 4.4 vs. 6.6 ± 3.3 mg/dl; P = 0.03. The histopathologic parameters of ICGN and PauciGN were comparable except for a higher proportion of sclerosed glomeruli in ICGN. At the end of 3 months follow-up, only two patients went into complete remission (5.4%. Majority of the patients had end-stage renal failure (48.6% and were dialysis dependent and seven patients (18.9% expired. There was no signifi difference in the renal survival (10.9 ± 1.9 vs. 9.6 ± 3.3 months or patient survival (17.5 ± 2.1 vs. 17.3 ± 4.3 months. The parameters associated with adverse outcomes at 3 months were hypertension (odds ratio [OR]: 0.58; confidence interval [CI]: 0.36–0.94, need for renal replacement therapy (OR: 0.19; CI: 0.04–0.9, serum creatinine at admission (P = 0.019, estimated glomerular filtration rate (P = 0.022 and percentage of fibrocellular crescents (P = 0.022.

  11. Crescentic IgA nephropathy.

    Science.gov (United States)

    Abuelo, J G; Esparza, A R; Matarese, R A; Endreny, R G; Carvalho, J S; Allegra, S R

    1984-11-01

    We report five cases of crescentic IgA nephropathy. All are males, 16-60 years of age. One case each came to medical attention with uremia, nephrotic syndrome, and gross hematuria; two cases presented with microhematuria and proteinuria on routine urinalysis. All had hypertension, azotemia (serum creatinine 1.6-9.4 mg/dl), proteinuria (greater than 6 g/24 hr in four cases), hypoalbuminemia (less than 3 g/dl), and hematuria (gross in two cases). All progressed to end-stage renal failure renal failure ending in dialysis (three cases) or death from unrelated causes (two cases). Prednisone, 60 mg/day for 1 month in two patients (with two 1-g doses of iv methylprednisolone in 1 case) did not improve the serum creatinine level, but one patient subsequently experienced a less rapid fall in renal function. A crescentic glomerulonephritis was present in all biopsies (crescents in 31-80% of glomeruli; mean, 50%). The size and stage of the crescents were variable. Numerous glomeruli had focal or diffuse sclerosis. In all cases, there was a 3 or 4+ deposition of IgA. Low-intensity staining for IgG and IgM was noted in four and three patients, respectively. On electron microscopy, dense granular mesangial deposits were noted in all cases and in four patients capillary subepithelial deposits were also observed. This form of IgA nephropathy is not common, but some studies indicate that it may occur in about 5% of patients with IgA nephropathy.

  12. Trip report : Crescent Lake National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This trip report is on a visit to Crescent Lake National Wildlife Refuge on September 20 and 21 2001. Wetlands inspected on the Moore Drainage included Martin,...

  13. Antiproteinase 3-and antimyeloperoxidase-associated vasculitis

    NARCIS (Netherlands)

    Franssen, CFM; Stegeman, CA; Kallenberg, CGM; Gans, ROB; de Jong, PE; Hoorntje, SJ; Tervaert, JWC

    Wegener's granulomatosis, microscopic polyangiitis, and idiopathic pauci-immune necrotizing crescentic glomerulonephritis (NCGN) are strongly associated with antineutrophil cytoplasmic autoantibodies (ANCAs) directed against either proteinase 3 (anti-PR3) or myeloperoxidase (anti-MPO). This has led

  14. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice

    NARCIS (Netherlands)

    Xiao, H; Heeringa, P; Hu, PQ; Liu, Z; Zhao, ML; Aratani, Y; Maeda, N; Falk, RJ; Jennette, JC

    2002-01-01

    Antineutrophil cytoplasmic autoantibodies (ANCAs) are identified in the circulation of approximately 80% of patients with pauci-immune necrotizing and crescentic glomerulonephritis and systemic small vessel vasculitis, such as microscopic polyangiitis and Wegener granulomatosis. The most common

  15. International Federation of Red Cross and Red Crescent Societies

    Science.gov (United States)

    ... Federation of Red Cross Red Crescent Societies (IFRC)... Hurricane Matthew: International Federation of Red Cross and Red Crescent ... communities Port-au Prince, 3 November 2016 —Since Hurricane Matthew struck Haiti one month ago, the Haiti Re... ...

  16. Scleroderma with crescentic glomerulonephritis: a case report

    Directory of Open Access Journals (Sweden)

    Ramaswami Arunachalam

    2008-05-01

    Full Text Available Abstract Introduction Systemic sclerosis or scleroderma is an autoimmune rheumatic disease characterized by organ-based fibrosis. Renal involvement in scleroderma occurs mainly in the form of scleroderma renal crisis, affecting 5 to 10% of patients. It remains one of the most important and immediately life-threatening complications of scleroderma, but the prognosis improves considerably after treatment with angiotensin-converting enzyme inhibitors. Other renal pathologies can occur in scleroderma. These include scleroderma overlap syndromes with associated features of lupus nephritis, myeloperoxidase anti-neutrophil cytoplasmic antibodies (ANCA or proteinase 3 ANCA-associated glomerulonephritis, or crescentic glomerulonephritis. These alternative pathologies should be suspected in any individual patient with a differing clinical picture and the patient should be appropriately investigated. Crescentic glomerulonephritis occurs very rarely in scleroderma. This report describes a patient with scleroderma and crescentic glomerulonephritis. Case presentation A 52-year-old woman with a known history of scleroderma and hypertension on angiotensin-converting enzyme inhibitors was referred to the nephrologist because of a rapid decline in renal function. Kidney biopsy was performed which revealed immune complex type crescentic glomrulonephritis. Cytoplasmic-staining ANCA was negative. Despite immunosuppressive treatment the patient rapidly went into end-stage renal failure and is still on hemodialysis. Conclusion Scleroderma is a complex disease, and the best characterized renal involvement in scleroderma is scleroderma renal crisis. However, other renal pathologies can occur in scleroderma. These alternative pathologies should be suspected in any patient with a differing clinical picture and the patient should be appropriately investigated, as the clinical course and treatment are different from the more common scleroderma renal crisis.

  17. Crescentic Glomerulonephritis Associated with Pulmonary Tuberculosis.

    Science.gov (United States)

    Kanodia, K V; Vanikar, A V; Patel, R D; Suthar, K S; Trivedi, H L

    2016-01-01

    Tuberculosis of kidney and urinary tract is caused by members of the Mycobacterium tuberculosis complex. Kidney is usually infected by haematogenous spread of bacilli from focus of infection in the lungs. Glomerular involvement in tuberculosis presenting as a rapidly progressive glomerulonephritis is a rare entity. We report a rare case of crescentic glomerulonephritis associated with pulmonary tuberculosis in a 26-year-old man. Patient was treated with corticosteroids, haemodialysis, intravenous immunoglobulin and four cycles of plasmapheresis. He did not respond to 4-drug anti-tuberculosis treatment for renal pathology and was switched over to maintenance haemodialysis. However, he responded to pulmonary TB.

  18. Atypical Pelvic Crescent Fracture Caused by Vertical Shear Force

    OpenAIRE

    2014-01-01

    The crescent fracture consists of a posterior iliac wing fracture with extension into the sacroiliac joint and a dislocation of the sacroiliac joint. This fracture represents a subset of lateral compression injury. The strong posterior ligaments of sacroiliac joint remain intact and a fracture fragment (crescent shape) involving the posterior superior iliac spines remains firmly attached to the sacrum. We report a patient with atypical pelvic crescent fracture that is mainly influenced by ver...

  19. 33 CFR 80.1152 - Crescent City Harbor, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Crescent City Harbor, CA. 80.1152 Section 80.1152 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1152 Crescent City Harbor, CA. A line...

  20. The vanishing wheat landraces of the Fertile Crescent

    Science.gov (United States)

    Genetic diversity of wheat landraces constituted a sizable portion of the mega diversity in the Fertile Crescent as a center of origin and of diversity of major crop plants. Following wheat domestication in the Fertile Crescent, early farmers developed diverse wheat landraces, and contributed to the...

  1. Rapidly progressive crescentic glomerulonephritis: Early treatment is a must.

    Science.gov (United States)

    Moroni, Gabriella; Ponticelli, Claudio

    2014-07-01

    The term crescentic glomerulonephritis (GN) refers to a pathologic condition characterized by extracapillary proliferation in >50% of glomeruli. Clinically crescentic GN is characterized by a nephritic syndrome rapidly progressing to end stage renal disease (ESRD). Three types of crescentic GN have been identified. Type 1 includes cases of Goodpasture syndrome characterized by linear deposits of antibodies along the glomerular basement membrane (GBM) at immunofluorescence. Type 2 is a heterogeneous group of primary or secondary glomerular diseases complicated by crescentic GN. In this category there are granular deposits of immunoglobulins and complement fractions on the glomerular tuft. Type 3 includes cases of ANCA-associated small-vessel vasculitis. Immunofluorescence is negative or may show only faint deposits of immunoglobulins. The etiology and the initial pathogenetic factors are different in the three types, but the final mechanisms leading to crescent formation and the renal symptoms and signs are similar. The prognosis depends on the timeline of diagnosis and treatment. Although some patients requiring dialysis may recover a good renal function, usually the higher the serum creatinine at presentation the worse the outcome. When treatment is initiated early, most patients obtain a complete or partial remission. High-dose corticosteroids and cyclophosphamide represent the standard therapy for crescentic GN. The addition of plasma exchange may also be helpful, particularly in patients with massive alveolar hemorrhage. Anti-B monoclonal antibodies have also been used in some patients with crescentic GN, but their role in this particular area is still poorly established. Published by Elsevier B.V.

  2. 肾组织浸润细胞在新月体肾炎患者中的分布特点及意义%The distribution and significance of renal infiltrating cells in patients with diffuse crescentic glomerulonephritis

    Institute of Scientific and Technical Information of China (English)

    唐政; 吴燕; 胡伟新; 姚小丹; 周红; 陈惠萍; 刘志红; 黎磊石

    2001-01-01

    Objective To study the significance and distribution of renal infiltrating cells, including monocytes (CD68+ cells), proliferative cell nuclear antigen positive cells (PCNA+ cells), CD4+ and CD8+ cells in diffuse crescent glomerulonephritis (DCGN). Methods Fifty-six patients with DCGN were studied, including 10 cases of anti-glomerular basement membrane (GBM)-type Ⅰ DCGN, 26 immune complex-type Ⅱ DCGN, and 20 cases of pauci-immune-type Ⅲ DCGN. Glomerular and interstitial infiltrates of CD68+ and PCNA+ cells, and interstitial infiltrates of CD4+ and CD8+ cells were detected by using four-layer PAP methods. Results There was a significant increase of renal infiltrating CD68+, PCNA+, CD4+ and CD8+ cells in patients with DCGN compared with that in normal controls. In patients with type Ⅰ DCGN, there was a higher number of renal infiltrating CD68+ and PCNA+ cells than that in patients with type Ⅱ and Ⅲ DCGN. A glomerular infiltrates of CD68+ and PCNA+ cells correlated with the interstitial infiltrates of CD4+ cells in type Ⅰ or Ⅲ DCGN patients. In lupus DCGN patients, the numbers of renal infiltrating CD68+ and PCNA+ cells were similar to vasculitis or type Ⅲ DCGN patients.Conclusion These findings demonstrate that the renal infiltrates of CD68+ and PCNA+ cells play an important role in patients with DCGN, that the infiltrates of CD4+ cells correlate with the infiltrates of CD68+ and PCNA+ cells may be an active marker of DCGN, and that cell-mediated immunity may contribute to crescent formation in lupus DCGN patients.%目的研究肾组织各种浸润细胞在各类新月体肾炎发生发展中的发病机制。方法分析56例各类新月体肾炎患者肾组织中单核细胞(CD68+)及增殖细胞核抗原阳性细胞(PCNA+)的分布特点,并就它们与肾组织中淋巴细胞亚群CD4+及CD8+细胞浸润的关系进行分析探讨。结果本组新月体患者肾组织中CD68+、PCNA+、CD4+及CD8+细胞均明显高于正常供肾组织。

  3. Crescent Lake National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Crescent Lake NWR for the next 15 years. This plan outlines the Refuge vision and...

  4. Environmental Assessment : Crescent Lake National Wildlife Refuge Hunting Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Environmental Assessment (EA) is for the implementation of the Crescent Lake National Wildlife Refuge Hunting Plan that serves as a step down management plan to...

  5. Summary of activities, Crescent Lake Refuge : April, 1938

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments for April of 1938. The report begins by summarizing the weather...

  6. Narrative report, Crescent Lake Refuge : September, October, November, & December, 1943

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1943. The report begins by...

  7. Narrative report, Crescent Lake Refuge : Quarter ending October 31, 1939

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1939. The report begins by summarizing...

  8. Quarterly narrative report, Crescent Lake Refuge : February, March, April, 1939

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1939. The report begins by summarizing...

  9. Crescent Lake Refuge Report of activities : Month of March, 1938

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments for March of 1938. The report begins by summarizing the weather...

  10. Summary of activities, Crescent Lake Refuge : February, 1938

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments for February of 1938. The report begins by summarizing the weather...

  11. Crescent City, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Crescent City, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  12. Crescent City, California 1 arc-second DEM

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1-second Crescent City, California Elevation Grid provides bathymetric data in ASCII raster format of 1-second resolution in geographic coordinates. This grid is...

  13. Crescent Lake Migratory Bird Refuge First quarter, fiscal year 1932

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, developments, public relations, and disease on Crescent Lake Migratory Bird Refuge...

  14. Quarterly report, Crescent Lake Refuge : May - June - July, 1938

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through July of 1938. The report begins by summarizing the...

  15. Narrative report, Crescent Lake Refuge : September, October, November & December, 1942

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1942. The report begins by...

  16. [Immunonegative necrotizing glomerulonephritis: an atypical case of lupus nephropathy].

    Science.gov (United States)

    Coll, E; Vallès, M; Torguet, P; Bronsoms, J; Maté, G; Bernadó, L; Mauri, J M

    2003-01-01

    We report here a case of systemic lupus erythematosus with severe, active pauci-immune necrotizing and crescentic glomerulonephritis. This patient had been diagnosed of a lupus nephritis type III previously and treated with steroids and azathioprine. After a renal symptomless period of nine years, she developed heavy proteinuria and hypertension. A second kidney biopsy was then performed. The pathological study disclosed a pauci-immune necrotizing crescentic and segmental glomerulonephritis. The absence of subendothelial and mesangial deposits was confirmed by both immunofluorescent microscopy and electron microscopy. The simultaneous immunological study showed normal ANCA levels while complement, anti-dsDNA and ANA were altered. The patient was treated with steroids and cyclophosphamide eith good response. This case points out the possibility previously recognized by others of an association between lupus and an pauci-immune necrotizing glomerulonephritis.

  17. Potential dominance of oscillating crescent waves in finite width tanks

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Madsen, Per A.

    2005-01-01

    Recently, it has been proposed that the emergence of previously observed oscillating crescent water wave patterns, created by class II (three-dimensional) instabilities which are in principle not dominant, could in fact be explained as an artifact of a finite width tank, combined with a suppression...

  18. Experimental study on modulational instability and evolution of crescent waves

    Directory of Open Access Journals (Sweden)

    Ya-long ZHOU

    2012-12-01

    Full Text Available A series of experiments on the instability of steep water wave trains in water with finite water depths and infinite water depths in a wide wave basin were performed. It was found that under the coupled development of modulational instability and class-II instability, the initial two-dimensional steep wave trains evolved into three-dimensional crescent waves, followed by the occurrence of disordered water surfaces, and that the wave energy transferred to sidebands in the amplitude spectrum of the water surface elevation. The results also show that water depth has a significant effect on the growth of modulational instability and the evolution of crescent waves. The larger the water depth, the more quickly the modulational instability suppresses class-II instability.

  19. Antiglomerular basement membrane antibody-crescentic glomerulonephritis complicating chronic bronchiectasis.

    Science.gov (United States)

    Enríquez, R; Cabezuelo, J B; Sirvent, A E; Andrada, E; Amorós, F; Orti, C

    2001-04-01

    A 68-year-old woman with chronic bronchiectasis presented with haematuria and severe oligoanuric renal failure with no other serious systemic manifestation. Antiglomerular basement membrane (anti-GBM) antibodies and anti-myeloperoxidase antibodies were positive. Renal biopsy revealed anti-GBM crescentic glomerulonephritis. A conservative approach was followed and the patient is stable on chronic haemodialysis 6 months later. To the authors' knowledge, there has only been one previous report of anti-GBM disease complicating bronchiectasis.

  20. Experimental crescentic glomerulonephritis: a new bicongenic rat model

    Directory of Open Access Journals (Sweden)

    Zelpha D’Souza

    2013-11-01

    Crescentic glomerulonephritis (CRGN is a major cause of human kidney failure, but the underlying mechanisms are not fully understood. Wistar Kyoto (WKY rats are uniquely susceptible to CRGN following injection of nephrotoxic serum, whereas Lewis (LEW rats are resistant. Our previous genetic studies of nephrotoxic nephritis (NTN, a form of CRGN induced by nephrotoxic serum, identified Fcgr3 and Jund as WKY genes underlying the two strongest quantitative trait loci for NTN phenotypes: Crgn1 and Crgn2, respectively. We also showed that introgression of WKY Crgn1 or Crgn2 individually into a LEW background did not lead to the formation of glomerular crescents. We have now generated a bicongenic strain, LEW.WCrgn1,2, in which WKY Crgn1 and Crgn2 are both introgressed into the LEW genetic background. These rats show development of NTN phenotypes, including glomerular crescents. Furthermore, we characterised macrophage function and glomerular cytokine profiles in this new strain. Additionally, we show that LEW.WCrgn1,2 rats are resistant to the development of glomerular crescents that is usually induced following immunisation with recombinant rat α3(IVNC1, the specific Goodpasture autoantigen located in the glomerular basement membrane against which the immune response is directed in experimental autoimmune glomerulonephritis. Our results show that the new bicongenic strain responds differently to two distinct experimental triggers of CRGN. This is the first time that CRGN has been induced on a normally resistant rat genetic background and identifies the LEW.WCrgn1,2 strain as a new, potentially valuable model of macrophage-dependent glomerulonephritis.

  1. Clinical spectrum of diffuse crescentic glomerulonephritis in Chinese patients

    Institute of Scientific and Technical Information of China (English)

    唐政; 吴燕; 王庆文; 曾彩虹; 姚小丹; 胡伟新; 陈惠萍; 刘志红; 黎磊石

    2003-01-01

    Objective To investigate retrospectively the incidence, distribution of primary disease and clinicopathologic characteristics of diffuse crescentic glomerulonephritis (DCGN) in Chinese patients.Methods One hundred and seventy-two consecutive patients diagnosed as having DCGN out of 9828 cases of non-transplanting renal biopsies over sixteen years, were studied. DCGN is categorized into three types according to immunopathologic characteristics. The incidence of this disease, its primary diseases, clinical characteristics and serum antineutrophil cytoplasmic antibodies (ANCAs) were analyzed.Results The distribution of patients among the three classifications was 8.7% type Ⅰ, 68.6% type Ⅱ and 22.7% type Ⅲ. Clinically, the majority of patients (69.8%) presented rapidly progressive glomerulonephritis (RPGN), but 30.2% manifested a chronic nephritic syndrome or chronic renal failure. In terms of related conditions, 93% were anemic, 61.6% had hypertension, 50.6% oliguria, 45.3% nephrotic syndrome, 43% uremic syndrome and 39.5% displayed gross hematuria. Those patients who were positive in serum for ANCAs had predominantly type Ⅲ DCGN. Two cases with anti-GBM-antibody crescentic glomerulonephritis and three with lupus nephritis were also positive for ANCAs in serum.Conclusion DCGN is not rare in Chinese patients. A majority of patients in our study presented with RPGN, but 30.2% manifested a chronic renal failure. Lupus patients with DCGN that were positive for ANCAs had more severe vasculitic lesions.

  2. Mesopotamian fertile crescent nearly gone, new study indicates

    Science.gov (United States)

    Showstack, Randy

    Something is terribly amiss in the marshlands of the fertile crescent of Mesopotamia, where the Tigris and Euphrates Rivers flow, and where Gilgamesh, the hero of an epic that dates at least as far back as the third millennium B.C., ruled.The marshlands, which are located primarily in Iraq and once extended between 15,000 and 20,000 square kilometers, now have been reduced to less than 1,500 to 2,000 square kilometers, according to a new study issued May 18 by the United Nations Environment Programme (UNEP). The marshlands could disappear in the near future if no immediate corrective actions are taken, according to Hassan Partow, the principal author of the UNEP study and a scientist within the agency's division of early warning and assessment.

  3. 78 FR 24717 - Crescent Ranger District; Deschutes National Forest; Klamath County, Oregon; Marsh Project...

    Science.gov (United States)

    2013-04-26

    ... Marsh, one of the largest high elevation wetland/marsh complexes in the continental United States. In... Forest Service Crescent Ranger District; Deschutes National Forest; Klamath County, Oregon; Marsh Project... statement (EIS) for a project called Marsh, in the southwestern portion of the Crescent Ranger District...

  4. Recent drying of the Fertile Crescent: natural or externally forced?

    Science.gov (United States)

    Kelley, Colin

    2014-05-01

    There has been a reduction in observed precipitation over the greater Mediterranean region since the middle of the 20th Century. Recent studies suggest that while anthropogenic forcing has already begun to assert itself in recent decades, the preponderance of the winter drying trend is attributable to the large natural multidecadal variability of the North Atlantic Oscillation (NAO), while over the eastern Mediterranean, the anthropogenic, or forced drying signal is more clearly evident. This forced drying is projected to increase during the 21st Century according to the newest global climate models and this aridification would present significant challenges for a region that is already water-stressed. Although the Fertile Crescent is historically known for its agricultural prosperity, the severity and persistence of the recent multiyear drought in Syria, directly prior to the 2011 uprising there, leads us to ask whether this is evidence of emerging global warming influence. This drought exacerbated existing water insecurity, resulting in an agricultural collapse and a mass migration of rural drought refugees to the urban areas in Syria's west. This migration followed the previous influx of Iragi refugees and combined with strong natural population growth to place a severe strain on resources. Here we examine observations of precipitation and temperature, both gridded and stations, along with simulations and projections from the newest global climate models, to estimate the forced contribution to the recent Syrian drought, and assess the uncertainty in future drying according to the models. We find that this region has experienced a long-term downward trend in precipitation, and a concomitant increase in temperature, serving to further dry the soil, and in surface pressure. We find that the shift in the distributions of three-year running means of surface pressure and precipitation due to the forcing make severe events such as the recent Syrian drought several

  5. Crescent Lake/North Platte National Wildlife Refuge Complex annual habitat management plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Crescent Lake/North Platte National Wildlife Refuge Complex Annual Habitat Management Plan provides a year long vision and specific guidance on managing habitats...

  6. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : 1970 annual narrative report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1970 calendar year. The report begins by...

  7. Crescent Lake National Wildlife Refuge Narrative report : 1 January to 30 April, 1958

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1958. The report begins by summarizing...

  8. Crescent Lake National Wildlife Refuge Quarterly narrative report : August, September and October, 1940

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from August through October of 1940. The report begins by...

  9. [Intra-Service Section 7 Consultation : Hunting Plan for Crescent Lake National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Intra-Service Section 7 evaluation for the 2004 Hunting Plan concurs that activities associated with the proposed Hunting Plan for Crescent Lake National...

  10. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual narrative report: Calendar year 1999

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1999 calendar year. The report...

  11. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual narrative report: Calendar year 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1994 calendar year. The report...

  12. Narrative report, Crescent Lake National Wildlife Refuge : Period ending August 31, 1952

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1952. The report begins by summarizing...

  13. Crescent Lake / North Platte National Wildlife Refuge Complex Integrated Pest Management Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of the Integrated Pest Management Plan is to provide a comprehensive, environmentally sensitive approach to managing pests on the Crescent Lake / North...

  14. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge annual narrative report : FY 1974

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1974 fiscal year. The report begins by summarizing...

  15. Crescent Lake National Wildlife Refuge Quarterly narrative report : February, March and April, 1941

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from February through April of 1941. The report begins by...

  16. Environmental Assessment: Sport Hunting Plan for Crescent Lake National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Environmental Assessment (EA) considers four alternatives for expanding hunting on Crescent Lake NWR. The preferred alternative is to expand hunting...

  17. Crescent Lake National Wildlife Refuge North Platte Easement Refuge: Annual Narrative Report, 1969

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1969 calendar year. A memorandum from the...

  18. [Narrative report, Crescent Lake Refuge and North Platte Easement Refuge : January, February, March & April, 1945

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1945. The report begins by summarizing...

  19. Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Slot, Marjan; van Paassen, Pieter; van Breda Vriesman, Peter; Heeringa, Peter; Tervaert, Jan Willem Cohen

    2005-01-01

    BACKGROUND: In a substantial proportion of patients with crescentic glomerulonephritis (CGN), both anti-glomerular basement membrane (GBM) antibodies and antineutrophil cytoplasmic antibodies (ANCAs) with specificity for myeloperoxidase (MPO-ANCA) are detected. In the present study, we questioned wh

  20. Quarterly narrative report, Crescent Lake Refuge : Quarter ending October 31, 1938

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from August through October of 1938. The report begins by...

  1. Summary of Activities, Crescent Lake and North Platte Refuges : May 1938

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge outlines Refuge accomplishments for May of 1938. The...

  2. Crescent Lake National Wildlife Refuge, North Platte Easement Refuge: Annual narrative report, 1972

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1972 calendar year. The report begins by...

  3. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual narrative report: Calendar year 1995

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1995 calendar year. The report...

  4. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual narrative report: Calendar year 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 2000 calendar year. The report...

  5. Crescent Lake National Wildlife Refuge Narrative report : 1 January to 30 April, 1957

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1957. The report begins by...

  6. Crescent Lake National Wildlife Refuge Narrative report : May 1 to August 31, 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1963. The report begins by summarizing...

  7. Crescent Lake National Wildlife Refuge Narrative report : January 1 to April 30, 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1963. The report begins by...

  8. Narrative report, Crescent Lake National Wildlife Refuge (May, June, July, August, 1950)

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1950. The report begins by summarizing...

  9. Crescent Lake National Wildlife Refuge North Platte Easement Refuge: Annual Narrative Report, 1968

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1968 calendar year. The report begins by...

  10. Quarterly narrative report for the quarter ending January 31, 1939. Crescent Lake Refuge.

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes weather conditions, wildlife, improvements and developments on Crescent Lake Migratory Bird Refuge during a part of the fiscal year...

  11. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual narrative report: Calendar year 1996

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1996 calendar year. The report...

  12. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual narrative report: Calendar year 2001

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 2001 calendar year. The report...

  13. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual Narrative Report: Calendar Year 2004

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 2004 calendar year. The report...

  14. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual Narrative Report: Calendar Year 2002

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 2002 calendar year. The report...

  15. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual Narrative Report: Calendar Year 2005

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 2005 calendar year. The report...

  16. Crescent Lake/North Platte National Wildlife Refuge Complex: Annual Narrative Report: Calendar Year 2003

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 2003 calendar year. The report...

  17. Crescent Lake National Wildlife Refuge Narrative report : September 1 to December 31, 1962

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1962. The report begins by...

  18. Crescent Lake National Wildlife Refuge Narrative report : September 1 to December 31, 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1963. The report begins by...

  19. Crescent Lake National Wildlife Refuge Narrative report : May 1 to August 31, 1961

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1961. The report begins by summarizing...

  20. Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Slot, Marjan; van Paassen, Pieter; van Breda Vriesman, Peter; Heeringa, Peter; Tervaert, Jan Willem Cohen

    BACKGROUND: In a substantial proportion of patients with crescentic glomerulonephritis (CGN), both anti-glomerular basement membrane (GBM) antibodies and antineutrophil cytoplasmic antibodies (ANCAs) with specificity for myeloperoxidase (MPO-ANCA) are detected. In the present study, we questioned

  1. Crescent Lake Migratory Bird Refuge Second quarter, fiscal year 1933 [1932

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, developments, public relations, and disease on Crescent Lake Migratory Bird Refuge...

  2. Knowledge and Attitude of Iranian Red Crescent Society Volunteers in Dealing with Bioterrorist attacks

    Directory of Open Access Journals (Sweden)

    Seyed Ali Bahreini Moghadam

    2016-01-01

    Full Text Available Introduction: Bioterrorism is a worldwide problem and has been the focus of attention during recent decades. There is no precise information on the knowledge, attitude, and preparedness of Iranian Red Crescent volunteers in dealing with bioterrorism. Therefore, the present study aimed to evaluate the above-mentioned parameters in Mahabad Red Crescent Society volunteers. Methods: In this prospective cross-sectional study, the knowledge of 120 volunteers was evaluated and rated as poor, moderate, and good. In addition, attitude of the volunteers and preparedness of Mahabad Red Crescent Society was rated as inappropriate and appropriate using a questionnaire. Results: The mean age of volunteers was 32.0 ± 8.2 years (62.5% male. 2 (1.7% volunteers had good knowledge while 94 (78.3% had no knowledge regarding bioterrorist attack management. Only 1 (0.8%  volunteer had appropriate attitude and 6 (5.0% stated their preparedness for being sent out to the crisis zone. 116 volunteers (96.7% indicated that Mahabad Red Crescent Society has an inappropriate level of preparedness to encounter bioterrorist attacks. Conclusion: The findings of the present study showed poor knowledge and inappropriate attitude of Mahabad Red Crescent Society volunteers in encountering probable bioterrorist attacks. Furthermore, the Red Crescent Society of this town had an inappropriate level of preparedness in the field of bioterrorism from the viewpoint of the studied volunteers.

  3. On the origin of the crescent-shaped distributions observed by MMS at the magnetopause

    Science.gov (United States)

    Lapenta, G.; Berchem, J.; Zhou, M.; Walker, R. J.; El-Alaoui, M.; Goldstein, M. L.; Paterson, W. R.; Giles, B. L.; Pollock, C. J.; Russell, C. T.; Strangeway, R. J.; Ergun, R. E.; Khotyaintsev, Y. V.; Torbert, R. B.; Burch, J. L.

    2017-02-01

    MMS observations recently confirmed that crescent-shaped electron velocity distributions in the plane perpendicular to the magnetic field occur in the electron diffusion region near reconnection sites at Earth's magnetopause. In this paper, we reexamine the origin of the crescent-shaped distributions in the light of our new finding that ions and electrons are drifting in opposite directions when displayed in magnetopause boundary-normal coordinates. Therefore, E × B drifts cannot cause the crescent shapes. We performed a high-resolution multiscale simulation capturing subelectron skin-depth scales. The results suggest that the crescent-shaped distributions are caused by meandering orbits without necessarily requiring any additional processes found at the magnetopause such as the highly asymmetric magnetopause ambipolar electric field. We use an adiabatic Hamiltonian model of particle motion to confirm that conservation of canonical momentum in the presence of magnetic field gradients causes the formation of crescent shapes without invoking asymmetries or the presence of an E × B drift. An important consequence of this finding is that we expect crescent-shaped distributions also to be observed in the magnetotail, a prediction that MMS will soon be able to test.

  4. Clinical-pathologic significance of CD163 positive macrophage in IgA nephropathy patients with crescents.

    Science.gov (United States)

    Li, Jun; Liu, Chang-Hua; Gao, Bo; Xu, Dao-Liang

    2015-01-01

    CD163, a marker of M2 macrophages, express anti-inflammatory properties. This study aims to investigate the difference of CD163 positive macrophages expression between IgA nephropathy patients with and without crescents. Renal tissues from IgAN patients (n = 24), including IgAN with crescents (n = 10), IgAN without crescents (n = 14), minimal change disease (MCD, as disease control, n = 8) and normal control kidneys (negative control, n = 3), were included in this study. Expressions of CD163 and CD68 in renal tissues were detected by immunohistochemistry or immunofluorescence. Compared with IgAN without crescent, IgAN patients with crescents have lower serum albumin and poor renal function. CD163 was mainly expressed in acute tubulointerstitial lesions. CD163 positive cells accumulate in areas around tubules with RBC casts. CD163 positive cells can also be seen in tubular lumen. CD163 positive cells can be seen in glomerular lesions, including endocapillary hypercellularity, cellular crescent and fibrous-cellular crescent. There were more CD163 positive cells in tubulointerstitial and glomerular lesions in IgAN patients with crescents. CD163 positive cells number in tubulointerstitial tissue was positive correlated with percentage of crescents, proteinuria, and negative correlated with serum albumin, eGFR. CD163 positive cells number in glomeruli was positive correlated with percentage of crescents, and was negative correlated with eGFR. Percentage of crescents was negative correlated with serum albumin, eGFR, and positive correlated with proteinuria. Dual staining showed that CD163 positive cells also expressed CD68. CD163 positive macrophages were involved in active crescent disease, acute tubular injury and glomerular lesions of IgAN with crescents.

  5. A Crescent Shaped Split Ring Resonator to Form a New Metamaterial

    Directory of Open Access Journals (Sweden)

    Nidal Abutahoun

    2012-10-01

    Full Text Available This paper proposes a new planner metamaterial consisting of crescent shaped split ring resonator unit cells. The cell is composed of a crescent shaped strip over one face of a dielectric substrate, and an oblong over the second face. The cell is very thin and easy to fabricate. The transmission characteristics of the structure were obtained using High Frequency Structure Simulator (HFSS commercial software by ANSOFT. Then the effective material properties were retrieved. All the transmission characteristics and material properties were plotted to show the material behavior with frequency. The new metamaterial provides a double negative refractive index over a specific frequency band.

  6. Immune mediated crescentic MPGN secondary to HBV infection: A rare presentation for a common infection.

    Science.gov (United States)

    Mareddy, Aswani Srinivas; Rangaswamy, Dharshan; Vankalakunti, Mahesha; Attur, Ravindra Prabhu; Nagaraju, Shankar Prasad; Koti, Neeraja

    2016-01-01

    Hepatitis B virus (HBV) infection presenting as crescentic glomerulonephritis in the absence of cryoglobulinemia is an extremely rare phenomenon. We report a case of a 44-year-old male with HBV infection, who underwent kidney biopsy for rapidly progressive renal failure and nephrotic range proteinuria. Histopathological evaluation of the kidney biopsy was consistent with immune complex mediated crescentic membranoproliferative glomerulonephritis (MPGN). The patient achieved complete renal and virological remission with steroids, plasmapheresis and antiviral therapy. This case report summarises the importance of early initiation of immunosuppression and plasmapheresis under antiviral coverage for improved clinical outcomes.

  7. Immune mediated crescentic MPGN secondary to HBV infection: A rare presentation for a common infection

    Directory of Open Access Journals (Sweden)

    Aswani Srinivas Mareddy

    2016-01-01

    Full Text Available Hepatitis B virus (HBV infection presenting as crescentic glomerulonephritis in the absence of cryoglobulinemia is an extremely rare phenomenon. We report a case of a 44-year-old male with HBV infection, who underwent kidney biopsy for rapidly progressive renal failure and nephrotic range proteinuria. Histopathological evaluation of the kidney biopsy was consistent with immune complex mediated crescentic membranoproliferative glomerulonephritis (MPGN. The patient achieved complete renal and virological remission with steroids, plasmapheresis and antiviral therapy. This case report summarises the importance of early initiation of immunosuppression and plasmapheresis under antiviral coverage for improved clinical outcomes.

  8. Crescentic Glomerulonephritis in IgA Multiple Myeloma: A Case Report

    Directory of Open Access Journals (Sweden)

    Grace T. Moscoso-Solorzano

    2011-09-01

    Full Text Available Background: There are few reports of glomerulonephritis (GN with crescents and a rapidly progressive course that lead to a diagnosis of a previously unsuspected B-cell dyscrasia. Case Presentation: We report a case of rapidly progressive GN: the patient showed no evidence of etiology at the time of biopsy and was diagnosed as IgA multiple myeloma (MM during investigation based on a renal biopsy. He presented diffuse proliferative and exudative GN and marked plasma cell infiltration of the kidney. Conclusion: The present case raises the possibility that proliferative GN with crescents may be a rare mode of presentation of MM.

  9. Anterior fracture dislocation of sacroiliac joint: A rare type of crescent fracture

    Directory of Open Access Journals (Sweden)

    Vivek Trikha

    2015-01-01

    Full Text Available Crescent fractures of the pelvis are usually described as posterior sacro iliac fracture dislocations. Rarely anterior displacement of the fractured iliac fragment along with dislocation has been reported in crescent fractures. Four cases of anterior fracture dislocation of the sacro iliac joint managed in the last two years by a single surgeon are presented. The injury mechanism, radiological diagnosis, management protocol along with functional outcomes of all the four patients have been discussed. CT scan is essential in the diagnosis and preoperative planning of this injury pattern. Early fixation along with proper reduction leads to excellent functional outcome in this subset of lateral compression injuries of the pelvis.

  10. Tectonic and igneous geology of the northern Shoshone Range, Nevada, with sections on gravity in Crescent Valley and economic geology

    Science.gov (United States)

    Gilluly, James; Gates, Olcott; Plouff, Donald; Ketner, K.B.

    1965-01-01

    Part of the northern Shoshone Range and its bordering valleys are shown in the Mount Lewis and Crescent Valley quadrangles of the U.S. Geological Survey's Topographic Atlas. A very small part of the Cortez Mountains extends into the Crescent Valley quadrangle and is also described.

  11. 75 FR 81307 - Notice of Availability of Record of Decision for the Tonopah Solar Energy, LLC, Crescent Dunes...

    Science.gov (United States)

    2010-12-27

    ...: 14X5017] Notice of Availability of Record of Decision for the Tonopah Solar Energy, LLC, Crescent Dunes Solar Energy Project AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Availability...) for the Tonopah Solar Energy Crescent Dunes Solar Energy Project Environmental Impact Statement...

  12. 76 FR 60475 - Issuance of a Loan Guarantee to Tonopah Solar Energy, LLC, for the Crescent Dunes Solar Energy...

    Science.gov (United States)

    2011-09-29

    ... Issuance of a Loan Guarantee to Tonopah Solar Energy, LLC, for the Crescent Dunes Solar Energy Project... 2009 (Recovery Act), to Tonopah Solar Energy, LLC (TSE), for construction and start-up of the Crescent Dunes Solar Energy Project (the Project). The Project is a proposed 110- megawatt solar power...

  13. 76 FR 47144 - In the Matter of: Jianwei Ding, 51 Bukit Batok Crescent, #0828 Unity Centre, Singapore 658077...

    Science.gov (United States)

    2011-08-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security In the Matter of: Jianwei Ding, 51 Bukit Batok Crescent, 0828 Unity..., Jianwei Ding, 51 Bukit Batok Crescent, 0828 Unity Centre, Singapore 658077; Registration : 29603-050,...

  14. Long-term statistics of extreme tsunami height at Crescent City

    Science.gov (United States)

    Dong, Sheng; Zhai, Jinjin; Tao, Shanshan

    2017-06-01

    Historically, Crescent City is one of the most vulnerable communities impacted by tsunamis along the west coast of the United States, largely attributed to its offshore geography. Trans-ocean tsunamis usually produce large wave runup at Crescent Harbor resulting in catastrophic damages, property loss and human death. How to determine the return values of tsunami height using relatively short-term observation data is of great significance to assess the tsunami hazards and improve engineering design along the coast of Crescent City. In the present study, the extreme tsunami heights observed along the coast of Crescent City from 1938 to 2015 are fitted using six different probabilistic distributions, namely, the Gumbel distribution, the Weibull distribution, the maximum entropy distribution, the lognormal distribution, the generalized extreme value distribution and the generalized Pareto distribution. The maximum likelihood method is applied to estimate the parameters of all above distributions. Both Kolmogorov-Smirnov test and root mean square error method are utilized for goodness-of-fit test and the better fitting distribution is selected. Assuming that the occurrence frequency of tsunami in each year follows the Poisson distribution, the Poisson compound extreme value distribution can be used to fit the annual maximum tsunami amplitude, and then the point and interval estimations of return tsunami heights are calculated for structural design. The results show that the Poisson compound extreme value distribution fits tsunami heights very well and is suitable to determine the return tsunami heights for coastal disaster prevention.

  15. Binary drop interaction on surfaces: onset and bounding ligaments of Crescent-Moon fragmentation

    Science.gov (United States)

    Bourouiba, Lydia; Wang, Yongji

    2016-11-01

    Drop impacts on surfaces can splash and create secondary droplets. These have important implications for industrial, environmental, and health processes such as air contamination by secondary pathogen-bearing droplets shaping disease transmission. Most studies of splash on surfaces have focused on the impact of one drop on a dry surface. Nevertheless, the outcome of impacts by spray or rain are shaped by the presence of adjacent sessile drops on the surface. Recently, in the context of rain and spray-induced disease transmission in crops, one particular binary drop interaction, the crescent-moon splash, was identified as a frequent and efficient source of secondary droplets (Gilet and Bourouiba ICB 2014 and JRSI 2015). The crescent-moon results from the interaction of an impacting drop with a sessile drop in the neighborhood of the impact point. Here, we report and rationalize the existence of a critical transition of impact parameters that enables the crescent-moon fragmentation to emerge. We also report and rationalize the peculiar, yet universal emergence of two bounding ligaments that are important in shaping the crescent-moon sheet.

  16. Teaching 21st Century Competencies: Lessons from Crescent Girls' School in Singapore

    Science.gov (United States)

    Trinidad, Gucci; Patel, Deepa; Shear, Linda; Goh, Peishi; Quek, Yin Kang; Tan, Chen Kee

    2013-01-01

    This paper presents case studies of two teachers at Crescent Girl's School (an all-girls high school in Singapore) who implemented strategies learned through a teacher professional development program called 21st Century Learning Design (21CLD). Policymakers often state requirements for teachers to focus on 21st century (21C) competencies without…

  17. Agriculture in the Fertile Crescent: Continuity and change under climate change

    Science.gov (United States)

    The Fertile Crescent is a highly biodiverse region where most temperate-zone agricultural species originated and were first domesticated. A favorable environment, a special plant community, and an adaptive population combined to initiate the transition from a hunter-gatherer economy to one based on ...

  18. Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.

    Science.gov (United States)

    Zeng, Yeting; Wang, Xinrui; Xie, Feilai; Zheng, Zhiyong

    2017-08-01

    Ischemic pseudo-cellular crescent (IPCC) that is induced by ischemia and composed of hyperplastic glomerular parietal epithelial cells resembles cellular crescent. In this study, we aimed to assess the clinical and pathological features of IPCC in renal biopsy to avoid over-diagnosis and to determine the diagnostic basis. 4 IPCC cases diagnosed over a 4-year period (2012-2015) were evaluated for the study. Meanwhile, 5 cases of ANCA-associated glomerulonephritis and 5 cases of lupus nephritis (LN) were selected as control. Appropriate clinical data, morphology, and immunohistochemical features of all cases were retrieved. Results showed that the basement membrane of glomerulus with IPCC appeared as a concentric twisted ball, and glomerular cells of the lesion were reduced even entirely absent, and the adjacent afferent arterioles showed sclerosis or luminal stenosis. Furthermore, immune globulin deposition, vasculitis, and fibrinous exudate have not been observed in IPCC. While the cellular crescents showed diverse characteristics in both morphology and immunostaining in the control group. Therefore, these results indicated that IPCC is a sort of ischemic reactive hyperplasia and associated with sclerosis, stenosis, or obstruction of adjacent afferent arterioles, which is clearly different from cellular crescents result from glomerulonephritis. Copyright © 2017 Elsevier GmbH. All rights reserved.

  19. Role of the Protease—activated Receptor—1 in Crescentic Glomerulonephritis

    Institute of Scientific and Technical Information of China (English)

    XinChen; PeterG.Tipping; ShaunR.Coughlin; EricRondeau

    2003-01-01

    Objective Fibrin deposition combined with glomerular epithelial cell proliferation and monocyte/macrophage infiltration is involved in the pathogenesis of crescentic glomerulonephritis and results from local thrombin generation.In addition to its effect on procoagulation and fibrinolysis,thrombin exerts many cellular effects through a functional thrombin receptor,protease-activated receptor-1(PAR-1).The paper is To determine the role of PAR-1 in the pathogenesis of crescentic glomerulonephritis.Methods wild type and PAR-1 knockout mice in an accelerated model of anti-glomerular basement menbrane antibody nephritis were studied.Results The wild type mice exhibited severe glomerular injury 10 days after injection of sheep anti-mouse glomerular besement membrane antibody,such as thrombus formation,extracapillary proiferation as well as renal failure.APR-1 knockout mice showed significant protection from crescentic glomerulonephritis.Conclusion PAR-1 plays a critical role in the pathogenesis of crescentic glomerulonephritis and may be a new target for therapeutic intervention.

  20. Investigation on the Degradation of Natural Heritage of Singing Sand Mountain and Crescent Moon Spring at Dunhuang City, China

    Institute of Scientific and Technical Information of China (English)

    Dong Jihong

    2007-01-01

    The main purpose of this study is to put forward a reasonable idea of the general protection for Singing Sand Mountain and Crescent Moon Spring,a rare and unique desert wonder,and of sustainable tourism development based on the research on the ecological environment around.Methods of documentation,case study and comparison were employed.Finally,aiming at solving the problems of natural environment and those existing after the exploitation of Singing Sand Mountain and Crescent Moon Spring the author puts forward three measures;the comprehensive treatment for Crescent Moon Spring(broadening resources of water and reducing expenditures,checking the decreasing depth of Crescent Moon Spring,and improving the geographical envkonment),the general protection envisions for Singing Sand Mountain and Crescent Moon Spring and establishing a dynamic monitoring and early-warning system of regional ecosystem.

  1. Quality of Health Services Provided to Iraqis at Jordan Red Crescent Health Centers

    Directory of Open Access Journals (Sweden)

    Taghrid S. Suifan

    2010-01-01

    Full Text Available Problem statement: Quality of services measurement has been the concern of many scholars who have tried to develop scales for it. The most popular scale used was SERVQUAL. Hence the aim of this study is to discover the quality of health services provided to Iraqis at Jordan Red Crescent Health Centers in Amman. Approach: A sample study was derived from (1652 male and female patients from five health centers: Ashrafieh Health Center; Al-Hashemi Health Center; Marka Health Center; Al-Taj Health Center and AL-Hussein Health Center. Means, Standard Deviation, Independent Sample T-Test, simple regression and the Scheffe Test were used to answer the study's main questions. Results: It was found that the quality of health services provided to the Iraqis at Jordan Red Crescent health centers was high in all dimensions, the highest quality dimensions displayed among the health service available at Jordan Red Crescent health centers were tangibles and assurance, whereas the lowest quality dimensions were empathy and responsiveness, there was a significant difference in the quality of health services provided to Iraqis at Jordan Red Crescent Health Centers (Ashrafieh Health Center, Al-Hashemi Health Center, Marka Health Center, Al-Taj Health Center and AL-Hussein Health Center from one center to another and there was a significant difference in the quality of health services provided to Iraqis at Jordan Red Crescent health centers based on the number of visits the Iraqis made to the center. Conclusion: The main recommendation presented in this study is that there is a need to expand the health services in cooperation with international humanitarian organizations in order to accommodate the rising number of Iraqis frequenting the centers.

  2. TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis.

    Science.gov (United States)

    Hünemörder, Stefanie; Treder, Julia; Ahrens, Stefanie; Schumacher, Valéa; Paust, Hans-Joachim; Menter, Thomas; Matthys, Patrick; Kamradt, Thomas; Meyer-Schwesinger, Catherine; Panzer, Ulf; Hopfer, Helmut; Mittrücker, Hans-Willi

    2015-09-01

    Autoimmunity against the Goodpasture antigen α3IV-NC1 results in crescentic glomerulonephritis (GN). Both antibodies and T cells directed against α3IV-NC1 have been implicated in disease development and progression. Using the model of experimental autoimmune glomerulonephritis (EAG) in DBA/1 mice, we aimed to characterize the frequency and function of α3IV-NC1-specific CD4(+) T cells in the kidneys. DBA/1 mice repeatedly immunized with human α3IV-NC1 developed necrotizing/crescentic GN. Kidneys with crescentic GN contained CD4(+) cells responding to α3IV-NC1 with the production of IFN-γ or IL-17A, demonstrating the accumulation of both α3IV-NC1-specific TH1 and TH17 cells. To test the functional relevance of TH1 and TH17 cells, EAG was induced in DBA/1 mice deficient in IFN-γR, IL-17A or IL-23p19. Mice of all knockout groups mounted α3IV-NC1 IgG, developed nephrotic range proteinuria, and IgG deposition to the glomerular basement membranes at levels similar to immunized wild-type mice. However, all knockout groups showed significantly fewer glomerular crescents and attenuated tubulointerstitial damage. Our results suggest that both α3IV-NC1-specific TH1 and TH17 cells accumulate in the kidneys and are crucial for the development of necrotizing/crescentic GN. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  3. 'Crescent Sign': Phase abnormality in radionuclide multigated study in tricuspid regurge: Description and clinical evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Ziada, G.; Abdel-Dayem, H.M.; Shafy, M.Z.; Constantinides, C.; Yousif, A.M.; Nair, N.

    1987-08-01

    A phase abnormality in radionuclide multigated studies (MUGA) in patients with tricuspid regurge (TR) is being described. In this condition of TR, as the right ventricle contracts, if causes the blood to regurge through the tricuspid valve to the right atrium and through the inferior Vena cava and hepatic veins to the adjacent liver tissue. As a result the right atrium and the liver will be in the same delayed phase forming a Crescent to the right side of the heart representing the right atrium and extending below the heart into the region of the liver. This Crescent has been graded according to how far it is extending in the liver and below the heart. In 15 patients with cardiac cath finding of TR (done within 2-3 days of the MUGA study), the phase displays of the radionuclide MUGA studies were analysed in order to find out the sensitivity of the Crescent Sign in the detection of TR and whether there is a relationship between the grade of the Crescent and the severity of the regurgitation. The Crescent was found in 13 of the 15 patients (sensitivity = 87%). We have not found a correlation between the severity of TR and the grade of the Crescent. We conclude that the presence of the Crescent Sign in phase display of the MUGA study should direct the attention of the clinician towards the recognition of TR, a condition which is sometimes difficult to diagnose non-invasively.

  4. Joint-bounded crescentic scars formed by subglacial clast-bed contact forces: Implications for bedrock failure beneath glaciers

    Science.gov (United States)

    Krabbendam, M.; Bradwell, T.; Everest, J. D.; Eyles, N.

    2017-08-01

    Glaciers and ice sheets are important agents of bedrock erosion, yet the precise processes of bedrock failure beneath glacier ice are incompletely known. Subglacially formed erosional crescentic markings (crescentic gouges, lunate fractures) on bedrock surfaces occur locally in glaciated areas and comprise a conchoidal fracture dipping down-ice and a steep fracture that faces up-ice. Here we report morphologically distinct crescentic scars that are closely associated with preexisting joints, termed here joint-bounded crescentic scars. These hitherto unreported features are ca. 50-200 mm deep and involve considerably more rock removal than previously described crescentic markings. The joint-bounded crescentic scars were found on abraded rhyolite surfaces recently exposed (ice produces a continuously migrating clast-bed contact force as it is dragged over the hard (bedrock) bed. As the ice-embedded boulder approaches a preexisting joint in the bedrock, stress concentrations build up in the bed that exceed the intact rock strength, resulting in conchoidal fracturing and detachment of a crescentic wedge-shaped rock fragment. Subsequent removal of the rock fragment probably involves further fracturing or crushing (comminution) under high contact forces. Formation of joint-bounded crescentic scars is favoured by large boulders at the base of the ice, high basal melting rates, and the presence of preexisting subvertical joints in the bedrock bed. We infer that the relative scarcity of crescentic markings in general on deglaciated surfaces shows that fracturing of intact bedrock below ice is difficult, but that preexisting weaknesses such as joints greatly facilitate rock failure. This implies that models of glacial erosion need to take fracture patterns of bedrock into account.

  5. Open wedge metatarsal osteotomy versus crescentic osteotomy to correct severe hallux valgus deformity

    DEFF Research Database (Denmark)

    Wester, Jens Ulrik; Hamborg-Petersen, Ellen; Herold, Niels

    2016-01-01

    BACKGROUND: Different techniques of proximal osteotomies have been introduced to correct severe hallux valgus. The open wedge osteotomy is a newly introduced method for proximal osteotomy. The aim of this prospective randomized study was to compare the radiological and clinical results after...... operation for severe hallux valgus, comparing the open wedge osteotomy to the crescentic osteotomy which is our traditional treatment. METHODS: Forty-five patients with severe hallux valgus (hallux valgus angle >35̊, and intermetatarsal angle >15̊) were included in this study. The treatment was proximal...... open wedge osteotomy and fixation with plate (Hemax), group 1, or operation with proximal crescentic osteotomy and fixation with a 3mm cannulated screw, group 2. The mean age was 52 years (19-71). Forty-one females and four males were included. Clinical and radiological follow-ups were performed 4...

  6. On the Relative Importance of Wave Focusing and Shelf or Harbor Resonance in Crescent City, CA

    Science.gov (United States)

    Arcas, D.

    2009-12-01

    It is well known that tsunami events that affect the western seaboard of the United States always impact strongly on the town of Crescent City, CA. Abnormally high tsunami wave height values when compared to those observed in the nearby towns of Brookings, OR and Eureka, CA are consistently recorded at the National Ocean Service (NOS) tide gauge in Crescent City harbor. It has been speculated that the main two physical phenomena responsible for the unusually large wave heights at this location are resonance and/or the presence of the Mendocino Escarpment, an over 1500 mile long asymmetric dislocation of the sea floor offshore of Crescent City with the potential for channeling part of the tsunami wave towards a specific location on the coastline. In connection with the resonant behavior of tsunami waves in the area, some studies have found the elevated wave heights to be generated by shelf resonance, while others have attributed the phenomenon to harbor resonance with a more localized effect. The implications of either shelf or harbor resonance are substantial. In the case of harbor resonance, modifications to the geometric configuration of the harbor may cancel or attenuate the resonant mode thus mitigating, at least partially, the tsunami hazard to the city. If shelf resonance is the dominant phenomenon, harbor modification will not significantly influence the wave behavior. The present study evaluates the relative importance of harbor resonance, shelf resonance and the presence of the Mendocino Escarpment on the abnormal tsunami wave heights consistently reported at Crescent City via analysis of recorded data and computer simulations of recent tsunami events.

  7. Crescent City, California Inner Harbor Basin and Entrance Channel. Draft. Supplemental Environmental Impact Statement.

    Science.gov (United States)

    1981-09-01

    for more efficient barge shipment of petroleum products into Crescent City Inner Harbor from the present to the year 2032. b. Improve the saftey ...Benthos. This element is considered a significant resource because of its position and importance in the food web. These organisms are filter...feeders, deposit feeders, scavengers and algae scrapers. They are used as food by a number of fish species. Benthos also contribute substantially to the

  8. Crescent bodies of Parachlamydia acanthamoeba and its life cycle within Acanthamoeba polyphaga: an electron micrograph study.

    Science.gov (United States)

    Greub, Gilbert; Raoult, Didier

    2002-06-01

    Parachlamydiaceae are endosymbionts of free-living amoeba first identified in 1997. Two developmental stages, elementary and reticulate bodies, were observed; however, their localization and proportions according to culture condition and duration remain unknown. The life cycle of Parachlamydia acanthamoeba within Acanthamoeba polyphaga was studied by transmission electron microscopy of 8-, 36-, and 144-h coculture. Morphometry and quantification were performed using SAMBA software. The elementary body, the predominant stage within the amoebae, was located mainly within their vacuoles. The multiplication of Parachlamydia bacteria by binary fission of reticulate bodies was independently associated with culture in PYG broth (odds ratio [OR] = 4.4; 95% confidence interval [CI], 1.55 to 12.46) and with the presence of reticulate bodies within the amoebae (OR = 2.10; 95% CI, 1.53 to 2.89). A third developmental stage was observed, the crescent body. Its presence outside and inside the amoebae was associated mainly with prolonged incubation time (OR = 3.98; 95% CI, 1.49 to 10.68, and OR = 5.98; 95% CI, 1.75 to 20.4, respectively). Elementary and crescent bodies were released into the extracellular medium within vesicles or after amoebal lysis. For both, phagocytosis was their mode of entry. This electron micrograph study revealed another infective developmental stage, the crescent body, and provided quantitative analysis of the life cycle of P. acanthamoeba within A. polyphaga.

  9. Opium trade and the spread of HIV in the Golden Crescent.

    Science.gov (United States)

    Farooq, Syeda Ayesha; Rasooly, Mohammad Hafiz; Abidi, Syed Hani; Modjarrad, Kayvon; Ali, Syed

    2017-07-21

    The Golden Crescent region of South Asia-comprising Afghanistan, Iran, and Pakistan-is a principal global site for opium production and distribution. Over the past few decades, war, terrorism, and a shifting political landscape have facilitated an active heroin trade throughout the region. Protracted conflict has exacerbated already dire socio-economic conditions and political strife within the region and contributed to a consequent rise in opiate trafficking and addiction among the region's inhabitants. The worsening epidemic of injection drug use has paralleled the rising incidence of HIV and other blood-borne infections in the region and drawn attention to the broader implications of the growing opiate trade in the Golden Crescent. The first step in addressing drug use is to recognize that it is not a character flaw but a form of mental illness, hence warranting humane treatment of drug users. It is also recommended that the governments of the Golden Crescent countries encourage substitution of opium with licit crops and raise awareness among the general public about the perils of opium use.

  10. 3D numerical simulation of the evolutionary process of aeolian downsized crescent-shaped dunes

    Science.gov (United States)

    Zhou, Xiaosi; Zhang, Yang; Wang, Yuan; Li, Min

    2016-06-01

    A dune constitutive model was coupled with a large eddy simulation (LES) with the Smagorinsky subgrid-scale (SGS) model to accurately describe the evolutionary process of dunes from the macroscopic perspective of morphological dynamics. A 3D numerical simulation of the evolution of aeolian downsized crescent-shaped dunes was then performed. The evolution of the 3D structure of Gaussian-shaped dunes was simulated under the influence of gravity modulation, which was the same with the vertical oscillation of the sand bed to adjust the threshold of sand grain liftoff in wind tunnel experiments under the same wind speed. The influence of gravity modulation intensity on the characteristic scale parameter of the dune was discussed. Results indicated that the crescent shape of the dune was reproduced with the action of gravity during regulation of the saturation of wind-sand flow at specific times. The crescent shape was not dynamically maintained as time passed, and the dunes dwindled until they reached final decomposition because of wind erosion. The height of the dunes decreased over time, and the height-time curve converged as the intensity of modulation increased linearly. The results qualitatively agreed with those obtained from wind tunnel experiments.

  11. [Narrative report, Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : May, June, July & August, 1946

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1946. The report begins by summarizing...

  12. Report of activities : Bullsnake (Pituophis melanoleucus sayi) research on the Crescent Lake National Wildlife Refuge, April-July 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Report on research activities regarding bullsnakes on the Crescent Lake National Wildlife Refuge, conducted by John Iverson and Earlham College. research was...

  13. Narrative report, Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : Period ending April, 30, 1949

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1949. The report begins by summarizing...

  14. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : January, February, March, April, 1953

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1953. The report begins by summarizing...

  15. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : September, October, November, December, 1954

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1954. The report begins by...

  16. Environmental Assessment : Chronic wasting disease management during an epidemic occurrence at Crescent Lake National Wildlife Refuge, Garden County, Nebraska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Environmental Assessment is needed to manage for chronic wasting disease on Crescent Lake NWR. There were two alternatives seriously considered: no action and...

  17. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : May, June, July, August, 1954

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1954. The report begins by summarizing...

  18. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge annual narrative report: Calendar year 1989

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1989 calendar year. The report...

  19. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge annual narrative report: Calendar year 1991

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1991 calendar year. The report...

  20. [Narrative report, Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : May, June, July & August 1948

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1948. The report begins by summarizing...

  1. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : September, October, November, December, 1953

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1953. The report begins by...

  2. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Annual Narrative Report : January 1 to December 31, 1966

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1966 calendar year. An April 26, 1967 memorandum...

  3. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : September 1 to December 31, 1956

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1956. The report begins by...

  4. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Annual Narrative Report : January 1 to December 31, 1965

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1965 calendar year. An April 27, 1966 memorandum...

  5. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : 1 May to 31 August, 1958

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1958. The report begins by summarizing...

  6. Quarterly narrative report : February, March and April, 1940 for Crescent Lake Migratory Waterfowl Refuge and North Platte Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from February through April of 1940. The report begins by...

  7. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : May 1 to August 31, 1959

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1959. The report begins by summarizing...

  8. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : September 1 to December 31, 1959

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1959. The report begins by...

  9. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : September 1 to December 31, 1960

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1960. The report begins by...

  10. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : January 1 to April 30, 1960

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1960. The report begins by summarizing...

  11. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : May 1 to September 30, 1960

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1960. The report begins by summarizing...

  12. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : January 1 to April 30. 1959

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1959. The report begins by summarizing...

  13. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : January 1 to April 30, 1961

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1961. The report begins by summarizing...

  14. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : 1 September to 31 December, 1958

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1958. Wildlife- including...

  15. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : May 1 to August 31, 1962

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1962. The report begins by summarizing...

  16. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : May, June, July, August, 1951

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1951. The report begins by summarizing...

  17. [Narrative report, Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : May, June, July & August, 1949

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1949. The report begins by summarizing...

  18. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Annual narrative report: Calendar year 1983

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1983 calendar year. The report...

  19. Crescent Lake Migratory Bird Refuge Quarterly report on reservation wild life and activities appurtenant thereto. Third quarter, fiscal year 1935.

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements and developments on Crescent Lake Migratory Bird Refuge during fiscal year of 1935.

  20. [Narrative report, Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : September, October, November & December, 1947

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1947. The report begins by...

  1. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : January, February, March, April, 1956

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1956. The report begins by summarizing...

  2. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : September, October, November, December, 1955

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1955. The report begins by...

  3. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : May, June, July, August, 1956

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1956. The report begins by summarizing...

  4. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge annual narrative report: Calendar year 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1990 calendar year. The report...

  5. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Refuge narrative report : May, June, July, August, 1953

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1953. The report begins by summarizing...

  6. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge Annual Narrative Report : January 1 to December 31, 1967

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments during the 1967 calendar year. An August 21, 1968 memorandum...

  7. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : 1 September to 31 December, 1957

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1957. The report begins by...

  8. Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge annual narrative report: Calendar year 1992

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Crescent Lake and North Platte National Wildlife Refuge outlines Refuge accomplishments during the 1992 calendar year. The report...

  9. Crescent Lake Migratory Bird Refuge Report on reservation wild life and activities appurtenant thereto, first half of fiscal year 1934

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, developments, and public relations on Crescent Lake Migratory Bird Refuge between July...

  10. Crescent Lake Migratory Bird Refuge Quarterly report on reservation wild life and activities appurtenant thereto, third quarter, fiscal year 1933

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, and developments on Crescent Lake Migratory Bird Refuge between January and March of...

  11. Crescent Lake Migratory Bird Refuge Quarterly report on reservation wild life and activities appurtenant thereto. First quarter, fiscal year 1936.

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, developments, and public relations on Crescent Lake Migratory Bird Refuge between July...

  12. Crescent Lake Migratory Bird Refuge Annual report on reservation wild life and activities appurtenant thereto, fiscal year 1934

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, and developments on Crescent Lake Migratory Bird Refuge during fiscal year 1934.

  13. Crescent Lake Migratory Bird Refuge Annual report on reservation wild life and activities appurtenant thereto, fiscal year 1933

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, grazing, protection, improvements, developments, and public relations on Crescent Lake Migratory Bird Refuge during fiscal...

  14. [Narrative report, Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge : January, February, March & April, 1948

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1948. The report begins by summarizing...

  15. [Crescent Lake National Wildlife Refuge and North Platte National Wildlife Refuge narrative report : September 1 to December 31, 1961

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Crescent Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1961. Wildlife- including...

  16. Green tea polyphenol (--epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis.

    Directory of Open Access Journals (Sweden)

    Ting Ye

    Full Text Available Crescentic glomerulonephritis (GN is the most severe form of GN and is associated with significant morbidity and mortality despite aggressive immunotherapy with steroids, cytotoxic drugs, and plasmapheresis. We examined the therapeutic efficacy of the green tea polyphenol (--epigallocatechin-3-gallate (EGCG, 50 mg/kg BW/day x3 weeks, a potent anti-inflammatory and anti-oxidant agent, on experimental crescentic GN induced in 129/svJ mice by administration of rabbit anti-mouse glomerular basement membrane sera. Routine histology and key molecules involved in inflammatory and redox signaling were studied. EGCG treatment significantly reduced mortality, decreased proteinuria and serum creatinine, and markedly improved renal histology when compared with vehicle-treated mice. The improvements in renal function and histology were accompanied by the restoration of Nrf2 signaling (which was impaired in vehicle-treated mice as shown by increased nuclear translocation of Nrf2 and cytoplasmic glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione peroxidase. EGCG-treated mice also showed reduction in p-Akt, p-JNK, p-ERK1/2 and p-P38 as well as restoration of PPARγ and SIRT1 levels. Lower dose of EGCG (25 mg/kg BW/day x2 weeks treatment also significantly decreased proteinuria and serum creatinine, and markedly improved renal histology when compared with vehicle-treated mice. Thus, our data illustrate the efficacy of EGCG in reversing the progression of crescentic GN in mice by targeting multiple signaling and inflammatory pathways as well as countering oxidative stress.

  17. Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis.

    Science.gov (United States)

    Ye, Ting; Zhen, Junhui; Du, Yong; Zhou, Jason K; Peng, Ai; Vaziri, Nosratola D; Mohan, Chandra; Xu, Yan; Zhou, Xin J

    2015-01-01

    Crescentic glomerulonephritis (GN) is the most severe form of GN and is associated with significant morbidity and mortality despite aggressive immunotherapy with steroids, cytotoxic drugs, and plasmapheresis. We examined the therapeutic efficacy of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG, 50 mg/kg BW/day x3 weeks), a potent anti-inflammatory and anti-oxidant agent, on experimental crescentic GN induced in 129/svJ mice by administration of rabbit anti-mouse glomerular basement membrane sera. Routine histology and key molecules involved in inflammatory and redox signaling were studied. EGCG treatment significantly reduced mortality, decreased proteinuria and serum creatinine, and markedly improved renal histology when compared with vehicle-treated mice. The improvements in renal function and histology were accompanied by the restoration of Nrf2 signaling (which was impaired in vehicle-treated mice) as shown by increased nuclear translocation of Nrf2 and cytoplasmic glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione peroxidase. EGCG-treated mice also showed reduction in p-Akt, p-JNK, p-ERK1/2 and p-P38 as well as restoration of PPARγ and SIRT1 levels. Lower dose of EGCG (25 mg/kg BW/day x2 weeks) treatment also significantly decreased proteinuria and serum creatinine, and markedly improved renal histology when compared with vehicle-treated mice. Thus, our data illustrate the efficacy of EGCG in reversing the progression of crescentic GN in mice by targeting multiple signaling and inflammatory pathways as well as countering oxidative stress.

  18. Spacecraft observations and analytic theory of crescent-shaped electron distributions in asymmetric magnetic reconnection

    CERN Document Server

    Egedal, J; Daughton, W; Wetherton, B; Cassak, P A; Chen, L -J; Lavraud, B; Trobert, R B; Dorelli, J; Gershman, D J; Avanov, L A

    2016-01-01

    Supported by a kinetic simulation, we derive an exclusion energy parameter $\\cal{E}_X$ providing a lower kinetic energy bound for an electron to cross from one inflow region to the other during magnetic reconnection. As by a Maxwell Demon, only high energy electrons are permitted to cross the inner reconnection region, setting the electron distribution function observed along the low density side separatrix during asymmetric reconnection. The analytic model accounts for the two distinct flavors of crescent-shaped electron distributions observed by spacecraft in a thin boundary layer along the low density separatrix.

  19. Monopole Crescent Elliptical Antenna with Band-Notched Characteristics for UWB Applications

    Institute of Scientific and Technical Information of China (English)

    JIAO Shengcai; GE Ning; LU Jianhua; JIANG Ming

    2009-01-01

    A compact antenna with extended band-notched characteristics was designed for ultra wideband (UWB) communications. The antenna consists of a crescent-shaped elliptical patch with a T-shaped stub and a square ground board plane. The antenna is easily integrated with radio-frequency/microwave circuits to reduce the manufacturing cost. The central frequency and the notch bandwidth can be adjusted by changing the size of the T-shaped stub. Simulations verify the design characteristics. Measurements show that the antenna produces the UWB working bandwidth.

  20. Design and implementation of a hospital information system for the Palestine Red Crescent Society in Lebanon.

    Science.gov (United States)

    Rossi, L; Materia, E; Hourani, A; Yousef, H; Racalbuto, V; Venier, C; Osman, M

    2009-01-01

    A case-mix hospital information system was designed and implemented in Palestine Red Crescent Society hospitals in order to support the network of Palestinian hospitals in Lebanon and to improve the health of refugees in the country. The system is based on routine collection of essential administrative and clinical data for each episode of hospitalization, relying on internationally accepted diagnostic codes. It is a computerized, user-friendly information system that is a stepping-stone towards better hospital management and evaluation of quality of care. It is also a useful model for the development of hospital information systems in Lebanon and in the Near East.

  1. Urinary Transforming Growth Factor-beta 1 as a marker of response to immunosuppressive treatment, in patients with crescentic nephritis

    Directory of Open Access Journals (Sweden)

    Sotsiou Florentia

    2005-12-01

    Full Text Available Abstract Background Crescentic nephritis is characterized by formation of cellular crescents that soon become fibrotic and result in irreversible damage, unless an effective immunosuppressive therapy is rapidly commenced. TGF-β1 is involved in the development of crescents through various pathways. The aim of this study was to identify whether the determination of urinary TGF-β1 levels in patients with crescentic nephritis could be used as a marker of response to treatment. Methods Fifteen patients with crescentic nephritis were included in the study. The renal expression of TGF-β1 was estimated in biopsy sections by immunohistochemistry and urinary TGF-β1 levels were determined by quantitative sandwich enzyme immunoassay (EIA. TGF-β1 levels were determined at the time of renal biopsy, before the initiation of immunosuppressive treatment (corticosteroids, cyclophosphamide and plasma exchange. Twelve patients with other types of proliferative glomerulonephritis and ten healthy subjects were used as controls. Results Improvement of renal function with immunosuppressive therapy was observed in 6 and stabilization in 4 patients (serum creatinine from 3.2 ± 1.5 to 1.4 ± 0.1 mg/dl and from 4.4 ± 1.2 to 4.1 ± 0.6 mg/dl, respectively. In 5 patients, with severe impairment of renal function who started on dialysis, no improvement was noted. The main histological feature differentiating these 5 patients from others with improved or stabilized renal function was the percentage patients with poor response to treatment were the percentage of glomeruli with crescents and the presence of ruptured Bowman's capsule and glomerular necrosis. Urinary TGF-β1 levels were significantly higher in patients who showed no improvement of renal function with immunosuppressive therapy (930 ± 126 ng/24 h vs. 376 ± 84 ng/24 h, p 1 was identified in crescents and tubular epithelial cells, whereas a significant correlation of TGF-β1 immunostaining with the presence

  2. Spatially resolved electron energy loss spectroscopy of crescent-shaped plasmonic antennas.

    Science.gov (United States)

    Křápek, V; Koh, A L; Břínek, L; Hrtoň, M; Tomanec, O; Kalousek, R; Maier, S A; Šikola, T

    2015-05-01

    We present a study of the optical properties of gold crescent-shaped antennas by means of electron energy loss spectroscopy. These structures exhibit particularly large field enhancement near their sharp features, support two non-degenerate dipolar (i.e., optically active) localised surface plasmon resonances, and are widely tunable by a choice of their shape and dimensions. Depending on the volume and shape, we resolved up to four plasmon resonances in metallic structures under study in the energy range of 0.8 - 2.4 eV: two dipolar and quadrupolar mode and a multimodal assembly. The boundary-element-method calculations reproduced the observed spectra and helped to identify the character of the resonances. The two lowest modes are of particular importance owing to their dipolar nature. Remarkably, they are both concentrated near the tips of the crescent, spectrally well resolved and their energies can be tuned between 0.8 - 1.5 eV and 1.2 - 2.0 eV, respectively. As the lower spectral range covers the telecommunication wavelengths 1.30 and 1.55 μm, we envisage the possible use of such nanostructures in infrared communication technology.

  3. Membranous nephropathy with crescents in a patient with Hashimoto's thyroiditis: a case report.

    Science.gov (United States)

    Thajudeen, Bijin; John, Santhosh G; Ossai, Nduka-Obi; Riaz, Irbaz B; Bracamonte, Erika; Sussman, Amy N

    2014-08-01

    Membranous nephropathy is a common cause of nephrotic syndrome in adults. It usually occurs secondary to underlying disease processes such as autoimmune disorders, malignancy, infection, and drugs. The presentation of nephrotic syndrome with concomitant precipitous decline in renal function warrants investigation of a coexistent disorder.We report the case of a 30-year-old male who presented with symptoms and signs of hypothyroidism.A diagnosis of Hashimoto's thyroiditis was contemplated based on the presence of high serum levels of antithyroglobulin and antithyroid peroxidase antibodies. Upon initiation of treatment with levothyroxine, patient symptomatology improved; however, the laboratory studies demonstrated continued elevated creatinine, hematuria, and proteinuria, which had not been addressed. Two months following treatment initiation, he had progressive deterioration in renal function and proteinuria. A renal biopsy revealed coexistent necrotizing and crescentic glomerulonephritis and membranous nephropathy.The final diagnosis was necrotizing, crescentic glomerulonephritis with superimposed membranous nephropathy likely secondary to Hashimoto's thyrodiitis.Induction treatment with oral cyclophosphamide and prednisone was started.At the end of 6 months of treatment, there was improvement in renal function and proteinuria and maintenance treatment with azathioprine and low-dose prednisone was initiated. This case highlights the importance of precise and detailed evaluation of patients with autoimmune diseases such as Hashimoto's thyroiditis particularly in the presence of active urine sediment. Proper evaluation and diagnosis of such patients has implications on the prognosis and response to treatment.

  4. Amphiphilic crescent-moon-shaped microparticles formed by selective adsorption of colloids.

    Science.gov (United States)

    Kim, Shin-Hyun; Abbaspourrad, Alireza; Weitz, David A

    2011-04-13

    We use a microfluidic device to prepare monodisperse amphiphilic particles in the shape of a crescent-moon and use these particles to stabilize oil droplets in water. The microfluidic device is comprised of a tapered capillary in a theta (θ) shape that injects two oil phases into water in a single receiving capillary. One oil is a fluorocarbon, while the second is a photocurable monomer, which partially wets the first oil drop; silica colloids in the monomer migrate and adsorb to the interface with water but do not protrude into the oil interface. Upon UV-induced polymerization, solid particles with the shape of a crescent moon are formed; removal of fluorocarbon oil yields amphiphilic particles due to the selective adsorption of silica colloids. The resultant amphiphilic microparticles can be used to stabilize oil drops in a mixture of water and ethanol; if they are packed to sufficient surface density on the interface of the oil drop, they become immobilized, preventing direct contact between neighboring drops, thereby providing the stability.

  5. Pediatric case of crescentic post-streptococcal glomerulonephritis with myeloperoxidase anti-neutrophil cytoplasmic antibody.

    Science.gov (United States)

    Kanai, Hiroaki; Sawanobori, Emi; Koizumi, Keiichi; Ohashi, Ryuji; Higashida, Kosuke

    2015-04-01

    Post-streptococcal glomerulonephritis (PSGN) generally has a good renal prognosis, and immunosuppressive therapies are not needed. However, a few patients present with severe acute kidney injury and extensive crescent formations. The etiology of such patients is not well known, and involvement of anti-neutrophil cytoplasmic antibodies is rarely reported. A 9-year-old girl with rapidly progressive nephritic syndrome was diagnosed with PSGN. A biopsy showed diffuse crescentic glomerulonephritis with immunoglobulin G and C3 deposits; moreover, humps were observed on electron microscopy. After she was administered methylprednisolone pulse therapy and intravenous cyclophosphamide, followed by prednisolone and azathioprine therapy, her urinary abnormalities improved and renal function normalized. However, the myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) titers gradually increased. We speculated that PSGN may be augmented by increased MPO-ANCA levels. Therefore, the patient is currently being treated with losartan, enalapril, azathioprine, and prednisolone. Although the MPO-ANCA titer remains high, urinary findings show mild proteinuria and her renal function has been norma for 18 months since onset. A progressive clinical course and severe histological findings may indicate the involvement of ANCA in deterioration of condition in patients with PSGN. Furthermore, in such cases immunosuppressive therapies should be considered even in pediatric PSGN.

  6. Ground-water potentialities in the Crescent Valley, Eureka and Lander Counties, Nevada

    Science.gov (United States)

    Zones, Christie Paul

    1961-01-01

    The Crescent Valley is an intermontane basin in Eureka and Lander Counties, just south of the Humboldt River in north-central Nevada. The valley floor, with an area of about 150 square miles, has a shape that more nearly resembles a Y than a crescent, although the valley apparently was named after the arc described by its southern part and northeastern arm. The northwestern arm of the Y extends northward to the small railroad town of Beowawe on the Humboldt River; the northeastern arm lies east of the low Dry Hills. The leg of the Y extends southwestward toward a narrow gap which separates the Crescent Valley from the Carico Lake Valley. The total drainage area of the Crescent Valley-about 700 square miles--includes also the slopes of the bordering mountain ranges: the Shoshone Range to the west, the Cortez Mountains to the east, and the Toiyabe Range to the south. The early history of the Crescent Valley was dominated by mining of silver and gold, centered at Lander in the Shoshone Range and at Cortez and Mill Canyon in the Cortez Mountains, but in recent years the only major mining activity has been at Gold Acres; there open-pit mining of low-grade gold ore has supported a community of about 200. For many years the only agricultural enterprises in the valley were two cattle ranches, but recently addition lands have been developed for the raising of crops in the west-central part of the valley. The average annual precipitation upon the floor of the Crescent Valley is probably less than 7 inches, of which only a little more than 1 inch formally falls during the growing season (from June through September). This is far less than the requirement of any plants of economic value, and irrigation is essential to agricultural development. Small perennial streams rising in the mountains have long been utilized for domestic supply, mining and milling activities of the past, and irrigation, and recently some large wells have been developed for irrigation. In 1956 the total

  7. Trafficking Golden Crescent Drugs into Western China: An Analysis and Translation of a Recent Chinese Police Research Article

    Science.gov (United States)

    2011-01-01

    8217Golden Crescent’ Drug Problem is Having on Our Country," (Lun ’Jin Xin Yue’ Dupin Wenti Dui Woguo de Yingxiang; it ’&$f£T # nnn M ggMHj IS ffl & nfo...economic difficulties in China’s impoverished interior, ethnic tensions, recidivism and drug addiction among ex-criminals, and other forces...Infiltration of ’Golden Crescent’ Illegal Drugs into Xinjiang" Original Chinese Title: Jinxinyue dupin dui Xinjiang zuosi shentou zongti taishi; ^$i

  8. Using multiple geochemical tracers to characterize the hydrogeology of the submarine spring off Crescent Beach, Florida

    Science.gov (United States)

    Swarzenski, P.W.; Reich, C.D.; Spechler, R.M.; Kindinger, J.L.; Moore, W.S.

    2001-01-01

    A spectacular submarine spring is located about 4 km east of Crescent Beach, FL, in the Atlantic Ocean. The single vent feature of Crescent Beach Spring provides a unique opportunity to examine onshore-offshore hydrogeologic processes, as well as point source submarine ground water discharge. The Floridan aquifer system in northeastern Florida consists of Tertiary interspersed limestone and dolomite strata. Impermeable beds confine the water-bearing zones under artesian pressure. Miocene and younger confining strata have been eroded away at the vent feature, enabling direct hydrologic communication of Eocene ground water with coastal bottom waters. The spring water had a salinity of 6.02, which was immediately diluted by ambient seawater during advection/mixing. The concentration of major solutes in spring water and onshore well waters confirm a generalized easterly flow direction of artesian ground water. Nutrient concentrations were generally low in the reducing vent samples, and the majority of the total nitrogen species existed as NH3. The submarine ground water tracers, Rn-222 (1174 dpm I-1, dpm), methane (232 nM) and barium (294.5 nM) were all highly enriched in the spring water relative to ambient seawater. The concentrations of the reverse redox elements U, V and Mo were expectedly low in the submarine waters. The strontium isotope ratio of the vent water (87Sr/86Sr = 0.70798) suggests that the spring water contain an integrated signature indicative of Floridan aquifer system ground water. Additional Sr isotopic ratios from a series of surficial and Lower Floridan well samples suggest dynamic ground water mixing, and do not provide clear evidence for a single hydrogeologic water source at the spring vent. In this karst-dominated aquifer, such energetic mixing at the vent feature is expected, and would be facilitated by conduit and fractured flow. Radium isotope activities were utilized to estimate flow-path trajectories and to provide information on

  9. Immature stages of the Brazilian crescent butterfly Ortilia liriope (Cramer) (Lepidoptera: Nymphalidae).

    Science.gov (United States)

    Silva, P L; Oliveira, N P; Barbosa, E P; Okada, Y; Kaminski, L A; Freitas, A V L

    2011-01-01

    We provide the first information on the morphology of the immature stages (egg, larva, and pupa), oviposition and larval behavior, and host plant, for the Brazilian crescent butterfly Ortilia liriope (Cramer), based on material from Santarém Municipality, Pará State, Northern Brazil. Females of O. liriope lay eggs in clusters. After hatching, larvae eat the exochorion and remain gregarious in all but the final instar. The host plant recorded in the study site is Justicia sp. (Acanthaceae). Despite the scarcity of data on the immature stages of Neotropical Melitaeini, we can already say that some morphological and behavioral traits observed in the immature stages of O. liriope are also present in all known genera in this tribe.

  10. Severidade de antracnose em folhas de sorgo submetido a doses crescentes de silício

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    Gil Rodrigues Santos

    Full Text Available A antracnose foliar é causada pelo fungo Colletotrichum sublineolum Hann. Kabát et Bub. (sin. C. graminicola (Ces. G.W. Wils. em plantas de sorgo podendo reduzir a produtividade de grãos e forragem, e o manejo adequado da nutrição mineral desta planta pode se apresentar como um mecanismo de controle sobre a antracnose. Dentre os minerais utilizados para o manejo de doenças, o silício destaca-se por reduzir a severidade das doenças em várias culturas. Diante do exposto, este trabalho teve por objetivo avaliar a severidade da antracnose em diferentes genótipos de sorgo suplementados com doses crescentes de silício. Para tal, realizaram-se experimentos em condições de casa de vegetação e de campo onde os genótipos de sorgo DOW 1F305 e A9735R foram suplementados com doses crescentes de silício (0; 500; 1.000; 1.500; 2.000; e 4.000 kg ha-1 e avaliados quanto à severidade da antracnose. Avaliou-se a severidade da doença por meio de uma escala de notas e, em seguida, amostras foram coletadas para determinação da concentração de silício nas folhas. Após a análise dos resultados, concluiu-se que houve redução na severidade da antracnose em resposta a adubação com silício para ambos os genótipos avaliados. Apesar do genótipo de sorgo DOW 1F305 acumular menores teores de silício em suas folhas, este genótipo foi mais resistente ao ataque da antracnose foliar.

  11. Toward Probabilistic Risk Analyses - Development of a Probabilistic Tsunami Hazard Assessment of Crescent City, CA

    Science.gov (United States)

    González, F. I.; Leveque, R. J.; Hatheway, D.; Metzger, N.

    2011-12-01

    Risk is defined in many ways, but most are consistent with Crichton's [1999] definition based on the ''risk triangle'' concept and the explicit identification of three risk elements: ''Risk is the probability of a loss, and this depends on three elements: hazard, vulnerability, and exposure. If any of these three elements in risk increases or decreases, then the risk increases or decreases respectively." The World Meteorological Organization, for example, cites Crichton [1999] and then defines risk as [WMO, 2008] Risk = function (Hazard x Vulnerability x Exposure) while the Asian Disaster Reduction Center adopts the more general expression [ADRC, 2005] Risk = function (Hazard, Vulnerability, Exposure) In practice, probabilistic concepts are invariably invoked, and at least one of the three factors are specified as probabilistic in nature. The Vulnerability and Exposure factors are defined in multiple ways in the relevant literature; but the Hazard factor, which is the focus of our presentation, is generally understood to deal only with the physical aspects of the phenomena and, in particular, the ability of the phenomena to inflict harm [Thywissen, 2006]. A Hazard factor can be estimated by a methodology known as Probabilistic Tsunami Hazard Assessment (PTHA) [González, et al., 2009]. We will describe the PTHA methodology and provide an example -- the results of a previous application to Seaside, OR. We will also present preliminary results for a PTHA of Crescent City, CA -- a pilot project and coastal modeling/mapping effort funded by the Federal Emergency Management Agency (FEMA) Region IX office as part of the new California Coastal Analysis and Mapping Project (CCAMP). CCAMP and the PTHA in Crescent City are being conducted under the nationwide FEMA Risk Mapping, Assessment, and Planning (Risk MAP) Program which focuses on providing communities with flood information and tools they can use to enhance their mitigation plans and better protect their citizens.

  12. C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases.

    Science.gov (United States)

    Gupta, Ruchika; Sharma, Alok; Agarwal, Sanjay K; Dinda, Amit K

    2015-11-01

    C1q nephropathy is a recently described clinico-pathologic entity with a variable clinical presentation and pathology. Crescentic glomerulonephritis (GN) has been reported in only two patients in the available literature. CD59 deficiency, along with lack of CD55, is responsible for paroxysmal nocturnal hemoglobinuria (PNH). Few cases of isolated CD59 deficiency have been described with PNH-like features. A middle-aged adult male presented with rapidly progressive renal failure. Serological investigations were negative. A renal biopsy revealed necrotizing crescentic GN with rupture of Bowman's capsule. Immunofluorescence on the frozen sections showed dominant mesangial deposits of C1q along with IgM. Hematological work-up of the patient revealed isolated CD59 deficiency. Hence, a final diagnosis of C1q nephropathy and CD59 deficiency manifesting as crescentic GN and hemolytic anemia was made. The co-existence of two rare disorders, C1q nephropathy and CD59 deficiency, in a patient with necrotizing crescentic GN is described for the first time to the best of our knowledge. The pathogenetic link of these two entities with the clinical manifestation requires further study.

  13. C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases

    Directory of Open Access Journals (Sweden)

    Ruchika Gupta

    2015-01-01

    Full Text Available C1q nephropathy is a recently described clinico-pathologic entity with a variable clinical presentation and pathology. Crescentic glomerulonephritis (GN has been reported in only two patients in the available literature. CD59 deficiency, along with lack of CD55, is responsible for paroxysmal nocturnal hemoglobinuria (PNH. Few cases of isolated CD59 deficiency have been described with PNH-like features. A middle-aged adult male presented with rapidly progressive renal failure. Serological investigations were negative. A renal biopsy revealed necrotizing crescentic GN with rupture of Bowman′s capsule. Immunofluorescence on the frozen sections showed dominant mesangial deposits of C1q along with IgM. Hematological work-up of the patient revealed isolated CD59 deficiency. Hence, a final diagnosis of C1q nephropathy and CD59 deficiency manifesting as crescentic GN and hemolytic anemia was made. The co-existence of two rare disorders, C1q nephropathy and CD59 deficiency, in a patient with necrotizing crescentic GN is described for the first time to the best of our knowledge. The pathogenetic link of these two entities with the clinical manifestation requires further study.

  14. Geologic context of geodetic data across a Basin and Range normal fault, Crescent Valley, Nevada

    Science.gov (United States)

    Friedrich, A. M.; Lee, J.; Wernicke, B. P.; Sieh, K.

    2004-04-01

    Geodetic strain and late Quaternary faulting in the Basin and Range province is distributed over a region much wider than historic seismicity, which is localized near the margins of the province. In the relatively aseismic interior, both the magnitude and direction of geodetic strain may be inconsistent with the Holocene faulting record. We document the best example of such a disagreement across the NE striking, ˜55° NW dipping Crescent normal fault, where a NW oriented, 70 km geodetic baseline records contemporary shortening of ˜2 mm/yr orthogonal to the fault trace. In contrast, our geomorphic, paleoseismic, and geochronologic analyses of the Crescent fault suggest that a large extensional rupture occurred during the late Holocene epoch. An excavation across the fault at Fourmile Canyon reveals that the most recent event occurred at 2.8 ± 0.1 ka, with net vertical tectonic displacement of 4.6 ± 0.4 m at this location, corresponding to the release of ˜3 m of accumulated NW-SE extension. Measured alluvial scarp profiles suggest a minimum rupture length of 30 km along the range front for the event, implying a moment magnitude Mw of at least 6.6. No prior event occurred between ˜2.8 ka and ˜6.4 ± 0.1 ka, the 14C calender age of strata near the base of the exposed section. Assuming typical slip rates for Basin and Range faults (˜0.3 mm/yr), these results imply that up to one third, or ˜1 m, of the extensional strain released in the previous earthquake could have reaccumulated across the fault since ˜2.8 ka. However, the contemporary shortening implies that the fault is unloading due to a transient process, whose duration is limited to between 6 years (geodetic recording time) and 2.8 ka (the age of the most recent event). These results emphasize the importance of providing accurate geologic data on the timescale of the earthquake cycle in order to evaluate geodetic measurements.

  15. Climate Change In The Fertile Crescent And Implications Of The Recent Drought In Syria

    Science.gov (United States)

    Kelley, C. P.; Mohtadi, S.; Cane, M. A.; Seager, R.; Kushnir, Y.

    2015-12-01

    Prior to the Syrian uprising that began in 2011, the greater Fertile Crescent experienced the most severe drought in the instrumental record. For Syria, a country marked by poor governance and unsustainable agricultural and environmental policies, the drought had a catalytic effect contributing to political unrest. We show that the recent decrease in Syrian precipitation is a combination of natural variability and a long-term drying trend, and the unusual severity of the observed drought is here shown to be highly unlikely without this trend. Precipitation changes in Syria are linked to rising mean sea-level pressure in the Eastern Mediterranean, which also shows a long-term trend. There has been also a long-term warming trend in the Eastern Mediterranean, adding to the drawdown of soil moisture. No natural cause is apparent for these trends, whereas the observed drying and warming are consistent with model studies of the response to increases in greenhouse gases. Furthermore, model studies show an increasingly drier and hotter future mean climate for the Eastern Mediterranean. Analyses of observations and model simulations indicate that a drought of the severity and duration of the recent Syrian drought, which is implicated in the current conflict, has become more than twice as likely as a consequence of human interference in the climate system.

  16. Rhino-orbitocerebral mucormycosis in a patient with idiopathic crescentic glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Suzan Sanavi

    2013-01-01

    Full Text Available Mucormycosis, caused by mucorales, is an acute, rapidly progressive infection associated with high mortality. Rhino-orbitocerebral infection is the most common variant and is generally seen in association with immune deficiency syndromes. Prompt medical treatment of this infection and debridement decreases the mortality rate. We describe a 47-year-old man with crescentic glomerulonephritis on maintenance prednisolone therapy. He had earlier received steroid and cyclophosphamide pulse therapies. Renal functions improved following immunosuppressive treatment. In the third month of maintenance therapy, he presented to us with left-sided facial swelling and bloody nasal discharge. He had high blood sugar and acidic blood pH (ketoacidosis, probably due to steroid therapy. Magnetic resonance imaging of the head and sinuses showed inflammation and mass in the ethmoid sinus and nose with partial septal destruction, proptosis, global destruction of the left eye, brain infarction and carotid artery obliteration. Endoscopic biopsy of the sinuses revealed severe tissue necrosis. Samples of nasal discharge and biopsy tissue showed aseptate hyphae on light microscopy and culture, compatible with Rhizopus. The patient was treated with amphotericin B and multiple wound debridements along with ethmoidectomy and enucleation of the left eye. He was discharged in good general condition but with mild right hemiparesis. On follow-up examination at one year, there were no signs of fungal infection or renal dysfunction.

  17. Late Holocene droughts in the Fertile Crescent recorded in a speleothem from northern Iraq

    Science.gov (United States)

    Flohr, Pascal; Fleitmann, Dominik; Zorita, Eduardo; Sadekov, Aleksey; Cheng, Hai; Bosomworth, Matt; Edwards, Lawrence; Matthews, Wendy; Matthews, Roger

    2017-02-01

    Droughts have had large impacts on past and present societies. High-resolution paleoclimate data are essential to place recent droughts in a meaningful historical context and to predict regional future changes with greater accuracy. Such records, however, are very scarce in the Middle East in general, and the Fertile Crescent in particular. Here we present a 2400 year long speleothem-based multiproxy record from Gejkar Cave in northern Iraq. Oxygen and carbon isotopes and magnesium are faithful recorders of effective moisture. The new Gejkar record not only shows that droughts in 1998-2000 and 2007-2010, which have been argued to be a contributing factor to Syrian civil war, were extreme compared to the current mean climate, but they were also superimposed on a long-term aridification trend that already started around or before 950 C.E. (Common Era). This long-term trend is not captured by tree ring records and climate models, emphasizing the importance of using various paleoclimate proxy data to evaluate and improve climate models and to correctly inform policy makers about future hydroclimatic changes in this drought-prone region.

  18. Broadband colored-crescent generation in a single {beta}-barium-borate crystal by intense femtosecond pulses

    Energy Technology Data Exchange (ETDEWEB)

    Wang, L.; Fan, Y. X.; Zhu, H.; Yan, Z. D.; Zhu, S. N.; Wang, Z. L. [Department of Physics and National Laboratory of Solid State Microstructures, Nanjing University, 210093 Nanjing (China); Zeng, H. [State Key Laboratory of Precision Spectroscopy, East China Normal University, 200062 Shanghai (China); Wang, H.-T. [Department of Physics and National Laboratory of Solid State Microstructures, Nanjing University, 210093 Nanjing (China); School of Physics, Nankai University, 300071 Tianjin (China)

    2011-12-15

    A visible colored crescent with a bandwidth broader than 220 nm is observed experimentally by loosely focused femtosecond pulses in a bulk quadratic nonlinear crystal ({beta}-BBO crystal) at certain incident angles. Through the analysis based on a simple collinear phase-matching model, we suggest that the colored crescent might be the coexistence of spontaneous parametric down-conversions (SPDCs) in the infrared range and the corresponding efficient second-order harmonic generations (SHGs) that occur in a wide spectrum. We further provide a possible mechanism for the SHG process in which the phase-mismatching angles of the frequency doubling of SPDCs in {beta}-BBO crystal are assumed to be compensated by the strong diffraction effect during the self-focusing process of the generated intense SPDC signals.

  19. To Study the Relationship between Organizational Intelligence and the Employee creativity (Case Study: Headquarter Staffs of Iranian Red Crescent Society

    Directory of Open Access Journals (Sweden)

    Abd-Al-Rasoul Torabi

    2016-09-01

    Full Text Available This research has been done aimed to study the relationship between organizational intelligence with the employee creativity in headquarters of Iranian Red Crescent Society on 2015. Research methodology is descriptive-survey; research type is applied research; research method is survey; and data collecting method is field. Statistical population of the research included all headquarters staffs of Red Crescent Society whom were 1500 people. Statistical sampling was 306 people and in a random sampling method. It was used questionnaire to collect data. It was used descriptive statistics to describe the state of subjects. Inferential statistics of Pearson correlation and linear regression was used to assess the significance of hypothesis. Findings confirmed a positive and significant relationship between organizational intelligence and its components with the employee creativity.

  20. Monitoring plant tissue nitrogen isotopes to assess nearshore inputs of nitrogen to Lake Crescent, Olympic National Park, Washington

    Science.gov (United States)

    Cox, Stephen E.; Moran, Patrick W.; Huffman, Raegan L.; Fradkin, Steven C.

    2016-05-31

    Mats of filamentous-periphytic algae present in some nearshore areas of Lake Crescent, Olympic National Park, Washington, may indicate early stages of eutrophication from nutrient enrichment of an otherwise highly oligotrophic lake. Natural abundance ratios of stable isotopes of nitrogen (δ15N) measured in plant tissue growing in nearshore areas of the lake indicate that the major source of nitrogen used by these primary producing plants is derived mainly from atmospherically fixed nitrogen in an undeveloped forested ecosystem. Exceptions to this pattern occurred in the Barnes Point area where elevated δ15N ratios indicate that effluent from septic systems also contribute nitrogen to filamentous-periphytic algae growing in the littoral zone of that area. Near the Lyre River outlet of Lake Crescent, the δ15N of filamentous-periphytic algae growing in close proximity to the spawning areas of a unique species of trout show little evidence of elevated δ15N indicating that nitrogen from on-site septic systems is not a substantial source of nitrogen for these plants. The δ15N data corroborate estimates that nitrogen input to Lake Crescent from septic sources is comparatively small relative to input from motor vehicle exhaust and vegetative sources in undeveloped forests, including litterfall, pollen, and symbiotic nitrogen fixation. The seasonal timing of blooms of filamentous-periphytic algal near the lake shoreline is also consistent with nitrogen exported from stands of red alder trees (Alnus rubra). Isotope biomonitoring of filamentous-periphytic algae may be an effective approach to monitoring the littoral zone for nutrient input to Lake Crescent from septic sources.

  1. Complete remission of nephrotic syndrome and acute kidney injury in crescentic IgA nephropathy: Role of mycophenolate sodium

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    D Bhandari

    2016-01-01

    Full Text Available Optimal therapy and prognosis of crescentic-IgA nephropathy (C-IgAN are not known. Reported treatment options for C-IgAN include combination of corticosteroids and cyclophosphamide for 6 months. The role of mycophenolate sodium in C-IgAN is unknown. We report a case of C-IgAN that was successfully treated with combination immunosuppressive therapy.

  2. Functional Traits Differ between Cereal Crop Progenitors and Other Wild Grasses Gathered in the Neolithic Fertile Crescent

    OpenAIRE

    Cunniff, J.; Wilkinson, S.; Charles, M.; G. Jones; Rees, M. van; Osborne, CP

    2014-01-01

    The reasons why some plant species were selected as crops and others were abandoned during the Neolithic emergence of agriculture are poorly understood. We tested the hypothesis that the traits of Fertile Crescent crop progenitors were advantageous in the fertile, disturbed habitats surrounding early settlements and in cultivated fields. We screened functional traits related to competition and disturbance in a group of grass species that were increasingly exploited by early plant gatherers, a...

  3. [Notes on the Indian Red Crescent aid and Dr. Ensari's contributions before the decline of the Ottoman Empire].

    Science.gov (United States)

    Izgöer, Ahmet Zeki

    2002-01-01

    This article deals with the Indian Red Crescent aids and Dr. Ahmed Ensari's role in this activity during the wars in the early 20th century that led the Ottoman Empire to dismantle. The Indian Red Crescent presided by Dr. Ensari sent a medical team and sanitary material for the Ottomans battered during the war in Tripoli (1911) and the succeeding war at the Balkans (1912). The article also deals with the meetings of the above-mentioned medical team with the Ottoman statesmen and dignitaries; its success at the Tripoli front and its projects concerning the Ottoman immigrants from the Balkan region. The humanitarian aids of the Indian Red Crescent continued afterwards, especially during the World War II (1914-1918) and the War of Independence (1919-1922). On their return to India, Dr. Ensari and the members of the team held a series of meetings and spoke of their activities to the people in their country. They tried to spread their sympathy for the Ottoman-Turkish people even to the outposts of India. This article is an attempt to describe the sympathy of this brother nation (Pakistan of today) proved by their aids and support far away from their borders.

  4. Crescent Lake Migratory Bird Refuge Quarterly report on reservation wild life and activities appurtenant thereto. Second quarter, fiscal year 1935. [1934

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report summarizes wildlife, protection, improvements, and developments on Crescent Lake Migratory Bird Refuge during fiscal year 1934.

  5. Percutaneous Screw Fixation of Crescent Fracture-Dislocation of the Sacroiliac Joint.

    Science.gov (United States)

    Shui, Xiaolong; Ying, Xiaozhou; Mao, Chuanwan; Feng, Yongzeng; Chen, Linwei; Kong, Jianzhong; Guo, Xiaoshan; Wang, Gang

    2015-11-01

    Crescent fracture-dislocation of the sacroiliac joint (CFDSIJ) is a type of lateral compression pelvic injury associated with instability. Open reduction and internal fixation is a traditional treatment of CFDSIJ. However, a minimally invasive method has never been reported. The purpose of this study was to assess the outcome of closed reduction and percutaneous fixation for different types of CFDSIJ and present their clinical outcome. The authors reviewed 117 patients diagnosed with CFDSIJ between July 2003 and July 2013. Closed reduction and percutaneous fixation was performed in 73 patients. Treatment selection was based on Day's fracture classification. For type I fractures, fixation perpendicular to the fracture line were performed. For type II fractures, crossed fixation was performed. For type III fractures, fixation was performed with iliosacral screws. Forty-four patients were treated by open reduction and plate fixation. Demographics, fracture pattern distribution, blood loss, incision lengths, revision surgeries, radiological results, and functional scores were compared. All 117 patients were followed for more than 6 months (mean, 14 months [range, 6-24 months]). Blood loss, extensive exposure, duration of posterior ring surgery, duration of hospital stay, and infection rates were lower in the closed group (P<.01). Patients in the closed group achieved better functional performance (P<.01). There were no significant differences in reduction quality (P=.32), revision surgery rates (P=.27), and iatrogenic neurologic injuries (P=.2) between the 2 groups. The authors' results indicate that closed reduction and percutaneous fixation is a safe and effective surgical method for CFDSIJ. Copyright 2015, SLACK Incorporated.

  6. Osteology of the crescent gunnel Pholis laeta and the phylogeny of the family Pholidae (Cottiformes, Zoarcoidei).

    Science.gov (United States)

    Sweetser, P W; Hilton, E J

    2016-09-01

    This study provides a complete description of the osteology of the crescent gunnel Pholis laeta based on cleared-and-stained specimens and X-rays to help provide sufficient morphological data to generate a robust phylogeny for the family Pholidae. Pholis laeta exhibits high variation in the structure of its caudal skeleton. The length of the preural (pu)2 neural spine is variably reduced (most common) or elongated (i.e. of similar length to that of pu3). Additionally, the neural spine of pu3 is either bifurcated or single. These results document and describe characters useful for phylogenetic inference of the family, including the insertion pattern of anal-fin pterygiophores between haemal spines. Pholidae was recovered as monophyletic (synapomorphies: ribs absent, haemonephropophyses present, gill membranes broadly joined, first neural arch fused to centrum, first anal-fin spine very robust, the dorsal fin comprises only spines and the presence of five branchiostegals), with monophyletic genera Pholis and Apodichthys (Rhodymenichthys is monotypic) and Apodichthys and Rhodymenichthys as sister taxa. The elongation of its pu2 neural spine defines Pholis and synapomorphies for Apodichthys include five infraorbital bones, no pelvic fin, a hypertrophied first anal-fin spine, the presence of two or three empty interhaemal spaces after the anteriormost anal-fin spine and having 35-46 abdominal vertebrae. Apodichthys and Rhodymenichthys are sister taxa based on the continuity of the caudal fin with the dorsal and anal fins and uniform colouration. Future study is needed to more fully resolve the interrelationships of species within Pholidae (especially the genus Pholis) and solidify the position of Pholidae within the Zoarcoidei.

  7. Long Term Population, City Size and Climate Trends in the Fertile Crescent: A First Approximation.

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    Dan Lawrence

    Full Text Available Over the last 8000 years the Fertile Crescent of the Near East has seen the emergence of urban agglomerations, small scale polities and large territorial empires, all of which had profound effects on settlement patterns. Computational approaches, including the use of remote sensing data, allow us to analyse these changes at unprecedented geographical and temporal scales. Here we employ these techniques to examine and compare long term trends in urbanisation, population and climate records. Maximum city size is used as a proxy for the intensity of urbanisation, whilst population trends are modelled from settlement densities in nine archaeological surveys conducted over the last 30 years across the region. These two measures are then compared with atmospheric moisture levels derived from multiple proxy analyses from two locations close to the study area, Soreq Cave in Israel and Lake Van in south-eastern Turkey, as well as wider literature. The earliest urban sites emerged during a period of relatively high atmospheric moisture levels and conform to a series of size thresholds. However, after the Early Bronze Age maximum urban size and population levels increase rapidly whilst atmospheric moisture declines. We argue that although the initial phase of urbanization may have been linked to climate conditions, we can see a definitive decoupling of climate and settlement patterns after 2000 BC. We relate this phenomenon to changes in socio-economic organisation and integration in large territorial empires. The complex relationships sustaining urban growth during this later period resulted in an increase in system fragility and ultimately impacted on the sustainability of cities in the long term.

  8. Sources and sinks of nitrogen and phosphorus to a deep, oligotrophic lake, Lake Crescent, Olympic National Park, Washington

    Science.gov (United States)

    Moran, P.W.; Cox, S.E.; Embrey, S.S.; Huffman, R.L.; Olsen, T.D.; Fradkin, S.C.

    2012-01-01

    Lake Crescent, in Olympic National Park in the northwest corner of Washington State is a deep-water lake renowned for its pristine water quality and oligotrophic nature. To examine the major sources and sinks of nutrients (as total nitrogen, total phosphorus, and dissolved nitrate), a study was conducted in the Lake Crescent watershed. The study involved measuring five major inflow streams, the Lyre River as the major outflow, recording weather and climatic data, coring lake bed sediment, and analyzing nutrient chemistry in several relevant media over 14 months. Water samples for total nitrogen, total phosphorous, and dissolved nitrate from the five inflow streams, the outlet Lyre River, and two stations in the lake were collected monthly from May 2006 through May 2007. Periodic samples of shallow water from temporary sampling wells were collected at numerous locations around the lake. Concentrations of nutrients detected in Lake Crescent and tributaries were then applied to the water budget estimates to arrive at monthly and annual loads from various environmental components within the watershed. Other sources, such as leaf litter, pollen, or automobile exhaust were estimated from annual values obtained from various literature sources. This information then was used to construct a nutrient budget for total nitrogen and total phosphorus. The nitrogen budget generally highlights vehicle traffic-diesel trucks in particular-along U.S. Highway 101 as a potential major anthropogenic source of nitrogen compounds in the lake. In contrast, contribution of nitrogen compounds from onsite septic systems appears to be relatively minor related to the other sources identified.

  9. A Whole Genome DArTseq and SNP Analysis for Genetic Diversity Assessment in Durum Wheat from Central Fertile Crescent

    Science.gov (United States)

    Shahid, Muhammad Qasim; Çiftçi, Vahdettin; E. Sáenz de Miera, Luis; Aasim, Muhammad; Nadeem, Muhammad Azhar; Aktaş, Husnu; Özkan, Hakan; Hatipoğlu, Rüştü

    2017-01-01

    Until now, little attention has been paid to the geographic distribution and evaluation of genetic diversity of durum wheat from the Central Fertile Crescent (modern-day Turkey and Syria). Turkey and Syria are considered as primary centers of wheat diversity, and thousands of locally adapted wheat landraces are still present in the farmers’ small fields. We planned this study to evaluate the genetic diversity of durum wheat landraces from the Central Fertile Crescent by genotyping based on DArTseq and SNP analysis. A total of 39,568 DArTseq and 20,661 SNP markers were used to characterize the genetic characteristic of 91 durum wheat land races. Clustering based on Neighbor joining analysis, principal coordinate as well as Bayesian model implemented in structure, clearly showed that the grouping pattern is not associated with the geographical distribution of the durum wheat due to the mixing of the Turkish and Syrian landraces. Significant correlation between DArTseq and SNP markers was observed in the Mantel test. However, we detected a non-significant relationship between geographical coordinates and DArTseq (r = -0.085) and SNP (r = -0.039) loci. These results showed that unconscious farmer selection and lack of the commercial varieties might have resulted in the exchange of genetic material and this was apparent in the genetic structure of durum wheat in Turkey and Syria. The genomic characterization presented here is an essential step towards a future exploitation of the available durum wheat genetic resources in genomic and breeding programs. The results of this study have also depicted a clear insight about the genetic diversity of wheat accessions from the Central Fertile Crescent. PMID:28099442

  10. Sources and sinks of nitrogen and phosphorus to a deep, oligotrophic lake, Lake Crescent, Olympic National Park, Washington

    Science.gov (United States)

    Moran, P.W.; Cox, S.E.; Embrey, S.S.; Huffman, R.L.; Olsen, T.D.; Fradkin, S.C.

    2012-01-01

    Lake Crescent, in Olympic National Park in the northwest corner of Washington State is a deep-water lake renowned for its pristine water quality and oligotrophic nature. To examine the major sources and sinks of nutrients (as total nitrogen, total phosphorus, and dissolved nitrate), a study was conducted in the Lake Crescent watershed. The study involved measuring five major inflow streams, the Lyre River as the major outflow, recording weather and climatic data, coring lake bed sediment, and analyzing nutrient chemistry in several relevant media over 14 months. Water samples for total nitrogen, total phosphorous, and dissolved nitrate from the five inflow streams, the outlet Lyre River, and two stations in the lake were collected monthly from May 2006 through May 2007. Periodic samples of shallow water from temporary sampling wells were collected at numerous locations around the lake. Concentrations of nutrients detected in Lake Crescent and tributaries were then applied to the water budget estimates to arrive at monthly and annual loads from various environmental components within the watershed. Other sources, such as leaf litter, pollen, or automobile exhaust were estimated from annual values obtained from various literature sources. This information then was used to construct a nutrient budget for total nitrogen and total phosphorus. The nitrogen budget generally highlights vehicle traffic-diesel trucks in particular-along U.S. Highway 101 as a potential major anthropogenic source of nitrogen compounds in the lake. In contrast, contribution of nitrogen compounds from onsite septic systems appears to be relatively minor related to the other sources identified.

  11. Open wedge metatarsal osteotomy versus crescentic osteotomy to correct severe hallux valgus deformity - A prospective comparative study.

    Science.gov (United States)

    Wester, Jens Ulrik; Hamborg-Petersen, Ellen; Herold, Niels; Hansen, Palle Bo; Froekjaer, Johnny

    2016-03-01

    Different techniques of proximal osteotomies have been introduced to correct severe hallux valgus. The open wedge osteotomy is a newly introduced method for proximal osteotomy. The aim of this prospective randomized study was to compare the radiological and clinical results after operation for severe hallux valgus, comparing the open wedge osteotomy to the crescentic osteotomy which is our traditional treatment. Forty-five patients with severe hallux valgus (hallux valgus angle >35̊, and intermetatarsal angle >15̊) were included in this study. The treatment was proximal open wedge osteotomy and fixation with plate (Hemax), group 1, or operation with proximal crescentic osteotomy and fixation with a 3mm cannulated screw, group 2. The mean age was 52 years (19-71). Forty-one females and four males were included. Clinical and radiological follow-ups were performed 4 and 12 months after the operation. In group 1 the hallux valgus angle decreased from 39.0̊ to 24.1̊ after 4 months and 27.9̊ after 12 months. In group 2 the angle decreased from 38.3̊ to 21.4̊ after 4 months and 27.0̊ after 12 months. The intermetatarsal angle in group 1 was 19.0̊ preoperatively, 11.6̊ after 4 months and 12.6̊ after 12 months. In group 2 the mean intermetatarsal angle was 18.9̊ preoperatively, 12.0̊ after 4 months and 12.6̊ after 12 months. The AOFAS score improved from 59.3 to 81.5 in group 1 and from 61.8 to 84.8 in group 2 respectively measured 12 months postoperatively. The relative length of the 1 metatarsal compared to 2 metatarsal bone was 0.88 and 0.87 preoperatively and 0.88 and 0.86 for group 1 and 2 respectively measured after 12 months. Crescentic osteotomy and open wedge osteotomy improve AOFAS score and VAS scores on patients operated with severe hallux valgus. No significant difference was found in the two groups looking at the postoperative improvement of HVA and IMA measured 4 and 12 months postoperatively. The postoperative VAS score and AOFAS score were

  12. Whether radial receptive field organization of the fourth extrastriate crescent (area V4A) gives special advantage for analysis of the optic flow. Comparison with the first crescent (area V2).

    Science.gov (United States)

    Levichkina, E V; Loshkarev, A A; Rodionova, E I; Popova, E P; Pigarev, I N

    2007-09-01

    Recently, elongated comet-shaped receptive fields were discovered in the fourth extrastriate crescent (area V4A) of cats and monkeys. It was shown that the long axes of these receptive fields were oriented radially toward the centre of the retina. Such unusual "radial" organization of this extrastriate area led to the assumption that these neurons may contribute to the analysis of optic flow. To investigate this assumption we recorded activity of neurons in the V4A of cats during real motion in depth toward or away from a stationary visual scene. Responses of neurons in area V4A were compared with activity of neurons in area V2 under similar conditions of stimulation. Area V2 is known to be sensitive to motion but does not have radial organization. It was found that a substantial number of visual neurons in both areas did not fire at all when cats were exposed to motion in depth. Nevertheless, neurons with selective activation to direction of motion in depth were identified, but comparable numbers were found in both areas studied. We conclude that radial organization of the fourth extrastriate crescent does not provide any special advantage for the analysis of optic flow information.

  13. Participacao crescente de produtos ultraprocessados na dieta brasileira (1987-2009

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    Ana Paula Bortoletto Martins

    2013-08-01

    ários. CONCLUSÕES Produtos ultraprocessados apresentam participação crescente na dieta brasileira, evidenciada desde a década de 1980 nas áreas metropolitanas e confirmada para todo o País na década de 2000.

  14. A Probabilistic Tsunami Hazard Assessment Methodology and Its Application to Crescent City, CA

    Science.gov (United States)

    Gonzalez, F. I.; Leveque, R. J.; Waagan, K.; Adams, L.; Lin, G.

    2012-12-01

    A PTHA methodology, based in large part on Probabilistic Seismic Hazard Assessment methods (e.g., Cornell, 1968; SSHAC, 1997; Geist and Parsons, 2005), was previously applied to Seaside, OR (Gonzalez, et al., 2009). This initial version of the method has been updated to include: a revised method to estimate tidal uncertainty; an improved method for generating stochastic realizations to estimate slip distribution uncertainty (Mai and Beroza, 2002; Blair, et al., 2011); additional near-field sources in the Cascadia Subduction Zone, based on the work of Goldfinger, et al. (2012); far-field sources in Japan, based on information updated since the 3 March 2011 Tohoku tsunami (Japan Earthquake Research Committee, 2011). The GeoClaw tsunami model (Berger, et. al, 2011) is used to simulate generation, propagation and inundation. We will discuss this revised PTHA methodology and the results of its application to Crescent City, CA. Berger, M.J., D. L. George, R. J. LeVeque, and K. T. Mandli, The GeoClaw software for depth-averaged flows with adaptive refinement, Adv. Water Res. 34 (2011), pp. 1195-1206. Blair, J.L., McCrory, P.A., Oppenheimer, D.H., and Waldhauser, F. (2011): A Geo-referenced 3D model of the Juan de Fuca Slab and associated seismicity: U.S. Geological Survey Data Series 633, v.1.0, available at http://pubs.usgs.gov/ds/633/. Cornell, C. A. (1968): Engineering seismic risk analysis, Bull. Seismol. Soc. Am., 58, 1583-1606. Geist, E. L., and T. Parsons (2005): Probabilistic Analysis of Tsunami Hazards, Nat. Hazards, 37 (3), 277-314. Goldfinger, C., Nelson, C.H., Morey, A.E., Johnson, J.E., Patton, J.R., Karabanov, E., Gutiérrez-Pastor, J., Eriksson, A.T., Gràcia, E., Dunhill, G., Enkin, R.J., Dallimore, A., and Vallier, T. (2012): Turbidite event history—Methods and implications for Holocene paleoseismicity of the Cascadia subduction zone: U.S. Geological Survey Professional Paper 1661-F, 170 p. (Available at http://pubs.usgs.gov/pp/pp1661f/). González, F

  15. Narrowing the harvest: Increasing sickle investment and the rise of domesticated cereal agriculture in the Fertile Crescent

    Science.gov (United States)

    Maeda, Osamu; Lucas, Leilani; Silva, Fabio; Tanno, Ken-Ichi; Fuller, Dorian Q.

    2016-08-01

    For the first time we integrate quantitative data on lithic sickles and archaeobotanical evidence for domestication and the evolution of plant economies from sites dated to the terminal Pleistocene and Early Holocene (ca. 12000-5000 cal. BCE) from throughout the Fertile Crescent region of Southwest Asia. We find a strong correlation in some regions, throughout the Levant, for increasing investment in sickles that tracks the evidence for increasing reliance on cereal crops, while evidence for morphological domestication in wheats (Triticum monococcum and Triticum dicoccum) and barley (Hordeum vulgare) was delayed in comparison to sickle use. These data indicate that while the co-increase of sickle blades and cereal crops support the protracted development of agricultural practice, sickles did not drive the initial stages of the domestication process but rather were a cultural adaptation to increasing reliance on cereals that were still undergoing selection for morphological change. For other regions, such as the Eastern Fertile Crescent and Cyprus such correlations are weaker or non-existent suggesting diverse cultural trajectories to cereal domestication. We conclude that sickles were an exaptation transferred to cereal harvesting and important in signalling a new cultural identity of "farmers". Furthermore, the protracted process of technological and agricultural evolution calls into question hypotheses that the transition to agriculture was caused by any particular climatic event.

  16. The effect of reconnection electric field on crescent and U-shaped distribution functions in asymmetric reconnection with no guide field

    Science.gov (United States)

    Bessho, N.; Chen, L.-J.; Hesse, M.; Wang, S.

    2017-07-01

    Electron distribution functions in the electron diffusion region in asymmetric reconnection without a guide field are studied by means of theory and 2-dimensional particle-in-cell (PIC) simulations. The effect of the reconnection electric field on crescent-shaped distribution functions is to broaden the thickness of the crescent. We express the thickness of the crescent as a function of field strengths, the distance from the X-line, and the time electrons spend executing meandering orbits. The electron distribution at the reconnection X-line exhibits a U-shaped structure with an opening angle in the direction of the reconnection electric field. We predict the opening angle of the U-shaped distribution by considering acceleration of the meandering electrons by the reconnection electric field. Results from particle tracing in PIC simulations and theoretical analysis agree. The above predictions provide guidance to interpret measurements by spacecraft from electron diffusion regions in asymmetric reconnection.

  17. Evaluation of Using Interdomal Suture and Crescentic Skin Excision with Standard Cleft Lip Repair for Correction of Cleft Lip-Nose Simultaneously with Primary Lip Repair

    Directory of Open Access Journals (Sweden)

    Mert Çalış

    2017-06-01

    Full Text Available Objective: The aim of this study is to compare the postoperative correction rates in the follow-up after simultaneous cleft lip nose (CLN repair with cleft lip repair using either interdomal suture or crescentic skin excision. Material and Methods: Eighty-three unilateral cleft lip patients were operated using modified Millard rotation advancement technique for cleft lip repair and simultaneous cleft lip repair using either interdomal suture or crescentic skin excision. The evaluation of the patients was made using routine standardized preoperative and early and later postoperative caudal nasal photographs. The distance between the nasal base and the most projectile point of the nostril was measured, and the ratio of the cleft side to the non-cleft side was calculated. Results: The highest rate was calculated in the early postoperative period in the crescentic skin excision group (1.07±0.29. The ratio was found to be 0.87±0.22 in patients with interdomal suture placement. The lowest rate was observed in patients who did not have any nasal reshaping procedure other than a standard cleft lip repair (0.71±0.16. The highest rate of recurrence was observed among the patients who had crescentic skin excision (0.39 ± 0.16. When recurrence rates were compared, a significant difference was observed in the crescentic skin excision group compared to the interdomal suture placed patients (p=0.005. Conclusion: The simultaneous primary rhinoplasty approach with cleft lip repair appears to be necessary for CLN repair in the long term. Although crescentic skin excision and placement of interdomal suture for this purpose achieve symmetry with the noncleft side and successful results in the early postoperative period, the probability of recurrence should always be taken in consideration. If either of these two techniques is to be preferred for CLN repair, then overcorrection should always be taken in consideration.

  18. Exigências de energia de borregas mestiças alimentadas com níveis crescentes de concentrado na dieta

    OpenAIRE

    Morais,M.G.; Fernandes,H.J.; Oliveira,L.B.; RIBEIRO, C. B.; Souza,A.R.D.L.; G.L. Franco; C.C.B.F. Ítavo; Andrade,A.G.F.; L.C.V. Ítavo; G.K.A. Melo; Walker, C. C.

    2016-01-01

    RESUMO Objetivou-se estimar as exigências energéticas de borregas mestiças confinadas, alimentadas com níveis crescentes de concentrado na dieta. Foram avaliadas 36 borregas, com peso corporal inicial de 23,7±3,67kg. Seis animais foram abatidos no início do experimento para obtenção dos valores do grupo referência. Os demais (30 animais) foram distribuídos em cinco tratamentos: mantença (alimentação restrita com feno de capim Tifton) e suplementados com níveis crescentes de concentrado (20, 4...

  19. An analysis of the moon's surface using reflected illumination from the earth during a waning crescent lunar phase

    Science.gov (United States)

    Hammond, Ernest C., Jr.; Linton-Petza, Maggie

    1989-01-01

    There have been many articles written concerning the lunar after-glow, the spectacular reflection from the moon's surface, and the possible observation of luminescence on the dark side of the moon. The researcher, using a 600 mm cassegrain telescope lense and Kodak 400 ASA T-Max film, photographed the crescent moon whose dark side was clearly visible by the reflected light from earth. The film was digitized to a Perkin-Elmer 1010M microdensitometer for enhancement and enlargement. The resulting pictures indicate a completely different land pattern formation than observed during a full moon. An attempt is made to analyze the observed structures and to compare them to the pictures observed during the normal full moon. There are boundaries on the digitized dark section of the moon that can be identified with structures seen during the normal full moon. But, these variations do change considerably under enhancement.

  20. Spectral Analysis of Water Level and Velocity Data from Crescent City Harbor During the April 1, 2014 Chilean Tsunami

    Science.gov (United States)

    Crawford, Gregory B.; Admire, Amanda R.; Dengler, Lori A.

    2017-08-01

    Crescent City, California typically records some of the largest waveheights along the US west coast for far-field tsunami sources and has suffered more loss than any North American site over the past century. We installed a Nortek Acoustic Doppler Profiler (ADP) in Crescent City Harbor in 2014 to better understand variations in water level and currents caused by forcing, such as tsunamis, tides, and weather events. A small tsunami was first detected in the harbor on April 2, 2014 and had a maximum peak-to-trough waveheight of 0.37 m. This event was near the ADP limit of detectability, with a peak observed tsunami current on the order of 0.16 m/s. Spectral analysis of water level and velocities before, during and after the tsunami shows well-defined spectral peaks with periods corresponding to roughly 20 and 5.6 min in both water level and velocity; elevated spectral levels also appear around 10 min, although a consistent peak location was less well defined. An additional peak appeared at around 2.5 min in water level but was not consistently observed in velocity. During the tsunami, spectral levels increased by roughly an order of magnitude around the 20-min peak (averaged over 24 h), with reduced levels at shorter periods. Motions around the 20-min period were aligned roughly NE-SW, approximately along the channel leading into the inner boat basin. At 5.6-min periods, the motion was roughly NW-SE, suggesting a higher-frequency modal response of the harbor.

  1. Granulomatosis with polyangiitis: rapidly progressive necrotizing glomerulonephritis in a pediatric patient

    Directory of Open Access Journals (Sweden)

    Luna M

    2014-04-01

    Full Text Available Mariana Luna,1 Victoria Bocanegra,3 Patricia G Vallés1,21Nephrology Division, Pediatric Department, Dr Humberto Notti Pediatric Hospital, Mendoza, Argentina; 2Pathophysiology Area, Pathology Department, School of Medicine, National Cuyo University, Mendoza, Argentina; 3National Council of Scientific and Technical Research of Argentina (CONICET, Buenos Aires, ArgentinaAbstract: Granulomatosis with polyangiitis (GPA is associated with a broad range of clinical manifestations including renal disease. It is a systemic vasculitis that is rarely encountered in children. We present a 14-year-old girl who suffered from pharyngitis 1 week before admittance to hospital. She was admitted for macroscopic hematuria and oliguria, under the possibility of nephritic syndrome. Renal failure with rapidly progressive glomerulonephritis occurred within 24 hours. Immunologic tests showed the presence of type-C anti-neutrophil cytoplasmic antibodies (c-ANCA with antiproteinase 3 specificity and renal biopsy revealed pauci-immune crescentic focal necrotizing glomerulonephritis. Treatment including methylprednisolone and cyclophosphamide intravenous pulses allowed renal recovery after 3 weeks. The clinical, hematological, and biochemical parameters improved substantially, achieving remission. Granulomatosis with polyangiitis, although rare in children, should be considered in the above clinical scenario. This case underlines that knowledge of renal histology diagnosis and early aggressive immunosuppressive therapy are essential for the management of these patients.Keywords: acute renal failure, vasculitis, crescentic pauci-immune glomerulonephritis-Type-C, antineutrophil cytoplasmic antibodies (c-ANCA-macroscopic hematuria

  2. TEOR, CONTEÚDO E ÍNDICE DE TRANSLOCAÇÃO DE NUTRIENTES EM MUDAS DE CEDRO (Cedrela fissilis VELL. SUBMETIDAS A DOSES CRESCENTES DE ZINCO

    Directory of Open Access Journals (Sweden)

    Haroldo Nogueira de Paiva

    2002-11-01

    Full Text Available Com o objetivo de avaliar os efeitos de doses crescentes de Zn sobre o teor, o conteúdo e o índice de translocação de nutrientes, mudas de cedro foram conduzidas em solução nutritiva de Clark, em condições de casa de vegetação do Departamento de Ciência do Solo da Universidade Federal de Lavras, e submetidas a doses crescentes de Zn: 2, 76, 152, 304 e 456 µmol L-1, adotando-se para tal um delineamento estatístico de blocos ao acaso. Ao final de 60 dias de exposição ao metal pesado, foram feitas avaliações do teor e do conteúdo de macro e de micronutrientes na matéria seca de raiz, caule, folhas, parte aérea e total, bem como da translocação desses nutrientes da raiz para a parte aérea. Os resultados mostram que, de maneira geral, há resposta diferenciada nos teores e redução no conteúdo de macro e de micronutrientes, independente da parte da planta analisada, ao passo que o índice de translocação de nutrientes é crescente com as doses de Zn aplicadas.

  3. Reticulated origin of domesticated emmer wheat supports a dynamic model for the emergence of agriculture in the fertile crescent.

    Directory of Open Access Journals (Sweden)

    Peter Civáň

    Full Text Available We used supernetworks with datasets of nuclear gene sequences and novel markers detecting retrotransposon insertions in ribosomal DNA loci to reassess the evolutionary relationships among tetraploid wheats. We show that domesticated emmer has a reticulated genetic ancestry, sharing phylogenetic signals with wild populations from all parts of the wild range. The extent of the genetic reticulation cannot be explained by post-domestication gene flow between cultivated emmer and wild plants, and the phylogenetic relationships among tetraploid wheats are incompatible with simple linear descent of the domesticates from a single wild population. A more parsimonious explanation of the data is that domesticated emmer originates from a hybridized population of different wild lineages. The observed diversity and reticulation patterns indicate that wild emmer evolved in the southern Levant, and that the wild emmer populations in south-eastern Turkey and the Zagros Mountains are relatively recent reticulate descendants of a subset of the Levantine wild populations. Based on our results we propose a new model for the emergence of domesticated emmer. During a pre-domestication period, diverse wild populations were collected from a large area west of the Euphrates and cultivated in mixed stands. Within these cultivated stands, hybridization gave rise to lineages displaying reticulated genealogical relationships with their ancestral populations. Gradual movement of early farmers out of the Levant introduced the pre-domesticated reticulated lineages to the northern and eastern parts of the Fertile Crescent, giving rise to the local wild populations but also facilitating fixation of domestication traits. Our model is consistent with the protracted and dispersed transition to agriculture indicated by the archaeobotanical evidence, and also with previous genetic data affiliating domesticated emmer with the wild populations in southeast Turkey. Unlike other

  4. 膜性肾病合并新月体形成的临床病理分析%Clinicopathologic characteristics of membranous nephropathy with crescents

    Institute of Scientific and Technical Information of China (English)

    钱玉珺; 左科; 李世军; 李晓梅; 曾彩虹; 刘志红; 吴燕

    2015-01-01

    Objective Membranous nephropathy ( MN) is rarely complicated by crescents.This study was to observe the clinicopathologic characteristics of MN with crescents. Methods This retrospective study included 53 cases of biopsy-proven idiopathic MN with crescents in the absence of immunologic and clinical etiologic factors and another 100 MN patients without histological crescents as controls.The clinicopathologic features, treatment response, and out-comes were analyzed and compared between the two groups of pa-tients. Results Significantly higher percentages of hypertension and decreased eGFR were observed in the MN +crescents group than in the control (47.2%vs 19.0%, P<0.05;28.3%vs 40.%, P<0.05).Circulating autoantibodies against the M-type phospholipase A2 receptor (PLA2R) were found in 66.7%(30/45) of the patients.The glomeruli exhibited a median of 4.6%(1.8%-35.3%) involvement of crescents.Compared with the controls, the MN +crescents group showed remarkably higher rates of segmental glomer-ulosclerosis lesions (16.0%vs 49.1%, P<0.05), capillary loops necrosis (0.0%vs 11.3%, P<0.05), interstitial fibrosis/tubu-lar atrophy (IFTA) (54.0%vs 86.8%, P<0.05) and afferent arterial lesions (65.0%vs 92.5%, P<0.05).No significant differ-ences were found in the outcomes of the two groups of patients. Conclusion MN with crescents is rare, and secondary MN and cres-centic glomerulonephritis should be considered.Crescentic MN usually presents with hypertension and renal dysfunction clinically and high rates of severe segmental and global glomerulosclerosis, capillary loops necrosis, and IFTA histologically.The condition has a fa-vorable short-term prognosis.%目的:膜性肾病( membranous nephropathy, MN)较少合并新月体形成,排除继发性MN、合并抗GBM肾炎、系统性血管炎、IgA肾病后更鲜有报道。文中旨在探讨此类患者的临床病理特征。方法回顾性分析南京军区南京总医院肾脏科2005年4月至2014年3月间肾活

  5. Blanking die design of manual scale mark for crescent hole%月牙形孔手动分度冲裁模设计

    Institute of Scientific and Technical Information of China (English)

    孟少明; 聂慧萍; 陈晨

    2013-01-01

    As a stainless steel impeller disk used for aviation,25 crescent holes are uniformly distributed on stamping part,and the size requirements of the hole positions should be met.According to the aviation parts feature,the blanking workpiece positioning scheme was determined,through the use of unique position mode and the coordination of high precision index plate,positioning shaft and shaft pin,a blanking die mechanism of manual scalemark for crescent hole was designed to realize the stamping of 25 uniform crescent shape holes.Production results show that the stamping die structure design is reasonable and convenient to operation.The size of workpiece in stamping processing fully meets the requirements of design drawings.%某航空用不锈钢叶轮盘零件需要冲压加工该零件上均布的25对月牙孔,并满足相应的孔位置尺寸要求.根据叶轮盘的零件特征,确定了工件的冲裁方案.采用独特的模具定位方式,通过高精度分度盘、定位轴与轴销三者的配合,设计了一种月牙形孔手动分度冲裁模机构,实现了对该零件上25个均布的月牙形孔手动分度冲压加工.生产结果表明,该冲裁模结构设计合理、操作方便,冲压加工的工件尺寸完全符合图纸设计要求.

  6. A legacy of divergent fishery management regimes and the resilience of rainbow and cutthroat trout populations in Lake Crescent, Olympic National Park, Washington

    Science.gov (United States)

    Brenkman, Samuel J.; Duda, Jeffrey J.; Kennedy, Philip R.; Baker, Bruce M.

    2014-01-01

    As a means to increase visitation, early fisheries management in the National Park Service (NPS) promoted sport harvest and hatchery supplementation. Today, NPS management objectives focus on the preservation of native fish. We summarized management regimes of Olympic National Park's Lake Crescent, which included decades of liberal sport harvest and hatchery releases of 14.3 million salmonids. Notably, nonnative species failed to persist in the lake. Complementary analyses of annual redd counts (1989–2012) and genetics data delineated three sympatric trout (one rainbow; two cutthroat) populations that exhibited distinct spatial and temporal spawning patterns, variable emergence timings, and genetic distinctiveness. Allacustrine rainbow trout spawned in the lake outlet from January to May. Cutthroat trout spawned in the major inlet tributary (Barnes Creek) from February to June and in the outlet river (Lyre) from September to March, an unusual timing for coastal cutthroat trout. Redd counts for each species were initially low (rainbow = mean 89; range 37–159; cutthroat = mean 93; range 18–180), and significantly increased for rainbow trout (mean 306; range 254–352) after implementation of catch-and-release regulations. Rainbow and cutthroat trout reached maximum sizes of 10.4 kg and 5.4 kg, respectively, and are among the largest throughout their native ranges. Morphometric analyses revealed interspecific differences but no intraspecific differences between the two cutthroat populations. Genetic analyses identified three distinct populations and low levels (9–17%) of interspecific hybridization. Lake Crescent rainbow trout were genetically divergent from 24 nearby Oncorhynchus mykiss populations, and represented a unique evolutionary legacy worthy of protection. The indigenous and geographically isolated Lake Crescent trout populations were resilient to overharvest and potential interactions with introduced fish species.

  7. Arthroscopic repair of large U-shaped rotator cuff tears without margin convergence versus repair of crescent- or L-shaped tears.

    Science.gov (United States)

    Park, Jin-Young; Jung, Seok Won; Jeon, Seung-Hyub; Cho, Hyoung-Weon; Choi, Jin-Ho; Oh, Kyung-Soo

    2014-01-01

    For large-sized tears of the rotator cuff, data according to the tear shape have not yet been reported for repair methodology, configuration, and subsequent integrity. The retear rate after the repair of large mobile tears, such as crescent- or L-shaped tears, is believed to be lower compared with retear rates after the repair of large U-shaped tears that are accompanied by anterior or posterior leaves of the rotator cuff. Cohort study; Level of evidence, 3. Data were collected and analyzed from 95 consecutive patients with a large-sized rotator cuff tear who underwent arthroscopic suture-bridge repair. Patients were divided into 2 groups: those having crescent- or L-shaped tears (mobile tear group, 53 patients) and those having U-shaped tears (U-shaped tear group, 42 patients). The integrity of the repaired constructs was determined by ultrasonography at 4.5, 12, and 24 months. Moreover, clinical evaluations were performed by using the Constant score, the American Shoulder and Elbow Surgeons (ASES) score, and muscle strength at intervals of 3, 6, 12, and 24 months postoperatively. On ultrasonography at 4.5, 12, and 24 months, a retear was detected in 6, 2, and 1 patients in the mobile tear group and in 5, 2, and 1 patients in the U-shaped tear group, respectively. Significant differences in retear rates were not detected between the groups overall or at each time point. Moreover, clinical scores were similar between groups, except for the presence of a temporarily higher Constant score at 12 months in the mobile tear group. With regard to shoulder strength, between-group comparisons indicated no statistically significant difference, either in abduction or external rotation, except for the presence of temporarily higher external rotation strength at 3 months in the mobile tear group. Arthroscopic repair of large-sized rotator cuff tears yielded substantial improvements in shoulder function, regardless of tear retraction, during midterm follow-up. Moreover, the

  8. The dynamics of filamentous structures in the apical band, oral crescent, fission line and the postoral meridional filament in Tetrahymena thermophila revealed by monoclonal antibody 12G9.

    Science.gov (United States)

    Jerka-Dziadosz, M; Strzyewska-Jówko, I; Wojsa-Lugowska, U; Krawczyńska, W; Krzywicka, A

    2001-05-01

    The ciliate Tetrahymena thermophila possesses a multitude of cytoskeletal structures whose differentiation is related to the basal bodies - the main mediators of the cortical pattern. This investigation deals with immunolocalization using light and electron microscopy of filaments labeled by the monoclonal antibody 12G9, which in other ciliates identifies filaments involved in transmission of cellular polarities and marks cell meridians with the highest morphogenetic potential. In Tetrahymena interphase cells, mAb 12G9 localizes to the sites of basal bodies and to the striated ciliary rootlets, to the apical band of filaments and to the fine fibrillar oral crescent. We followed the sequence of development of these structures during divisional morphogenesis. The labeling of the maternal oral crescent disappears in pre-metaphase cells and reappears during anaphase, concomitantly with differentiation of the new structure in the posterior daughter cell. In the posterior daughter cell, the new apical band originates as small clusters of filaments located at the base of the anterior basal bodies of the apical basal body couplets during early anaphase. The differentiation of the band is completed in the final stages of cytokinesis and in the young post-dividing cell. The maternal band is reorganized earlier, simultaneously with the oral structure. The mAb 12G9 identifies two transient structures present only in dividing cells. One is a medial structure demarcating the two daughter cells during metaphase and anaphase, and defining the new anterior border of the posterior daughter cell. The other is a post-oral meridional filament marking the stomatogenic meridian in postmetaphase cells. Comparative analysis of immunolocalization of transient filaments labeled with mAb12G9 in Tetrahymena and other ciliates indicates that this antibody identifies a protein bound to filamentous structures, which might play a role in relying polarities of cortical domains and could be a part

  9. The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation

    Science.gov (United States)

    Hachmo, Yafit; Kalechman, Yona; Skornick, Itai; Gafter, Uzi; Caspi, Rachel R.; Sredni, Benjamin

    2017-01-01

    Crescentic glomerulonephritis (CGN) is the most aggressive form of GN and, if untreated, patients can progress to end-stage renal failure within weeks of presentation. The α4β1 integrin very late antigen-4 (VLA-4) is an adhesion molecule of fundamental importance to the recruitment of leukocytes in inflammation. We addressed the role of VLA-4 in mediating progressive renal injury in a rat model of CGN using a small tellurium compound. AS101 [ammonium trichloro(dioxoethylene-o,o′)tellurate]. This compound has been previously shown to uniquely inhibit VLA-4 activity by redox inactivation of adjacent thiols in the exofacial domain of VLA-4. The study shows that administration of AS101 either before or after glomerular basement membrane anti-serum injection ameliorates crescent formation or preserves renal function. This was associated with profound inhibition of critical inflammatory mediators, accompanied by decreased glomerular infiltration of macrophages. Mechanistic studies demonstrated vla-4 inactivation on glomerular macrophages both in vitro and in vivo as well as inhibition of caspase-1 activity. Importantly, this cysteine protease activity modification was dependent on VLA-4 inactivation and was associated with the anti-inflammatory activity of AS101. We propose that inactivation of macrophage VLA-4 by AS101 in vivo results in a decrease of inflammatory cytokines and chemokines produced in the glomeruli of diseased rats, resulting in decreased further macrophage recruitment and decreased extracellular matrix expansion. Thus, AS101, which is currently in clinical trials for other indications, might be beneficial for treatment of CGN.

  10. Glomerular C3d as a novel prognostic marker for renal vasculitis.

    Science.gov (United States)

    Villacorta, Javier; Diaz-Crespo, Francisco; Acevedo, Mercedes; Guerrero, Carmen; Campos-Martin, Yolanda; García-Díaz, Eugenio; Mollejo, Manuela; Fernandez-Juarez, Gema

    2016-10-01

    Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series have analyzed the prognostic implications of complement glomerular deposits. This study aimed to assess the clinical and prognostic implications of C3d- and C4d-positive glomerular staining in renal vasculitis. Eighty-five patients with a diagnosis of pauci-immune necrotizing crescentic glomerulonephritis were included in the study. C3d and C4d were analyzed by immunohistochemical staining using a polyclonal antibody. The primary predictors were glomerular C3d- and C4d-positive staining. The primary end point was the cumulative percentage of patients who developed end-stage renal disease. Glomerular staining for C3d and C4d was observed in 42 (49.4%) of 85 biopsies and 38 (44.7%) of 85 biopsies, respectively. C3d-positive staining was associated with the severity of renal impairment and with a lower response rate to treatment (P=.003 and P=.04, respectively). Renal survival at 2 and 5 years was 60.9% and 51.8% in C3d-positive patients compared with 87.7% and 78.9% in C3d-negative patients (P=.04). C4d-positive staining did not show any impact in renal outcome. When adjusted by renal function and other histologic parameters, C3d staining remained as an independent predictor for renal survival (hazard ratio, 2.5; 95% confidence interval, 1.1-5.7; P=.03). Therefore, this study demonstrates that C3d-positive glomerular staining is an independent risk factor for the development of end-stage renal disease in ANCA-associated renal vasculitis.

  11. The grain Hardness locus characterized in a diverse wheat panel (Triticum aestivum L.) adapted to the central part of the Fertile Crescent: genetic diversity, haplotype structure, and phylogeny.

    Science.gov (United States)

    Shaaf, Salar; Sharma, Rajiv; Baloch, Faheem Shehzad; Badaeva, Ekaterina D; Knüpffer, Helmut; Kilian, Benjamin; Özkan, Hakan

    2016-06-01

    Wheat belongs to the most important crops domesticated in the Fertile Crescent. In this region, fortunately, locally adapted wheat landraces are still present in farmers' fields. This material might be of immense value for future breeding programs. However, especially wheat germplasm adapted to the central part of the Fertile Crescent has been poorly characterized for allelic variation at key loci of agricultural importance. Grain hardness is an important trait influencing milling and baking quality of wheat. This trait is mainly determined by three tightly linked genes, namely, Puroindoline a (Pina), Puroindoline b (Pinb), and Grain softness protein-1 (Gsp-1), at the Hardness (Ha-D) locus on chromosome 5DS. To investigate genetic diversity and haplotype structure, we resequenced 96 diverse wheat lines at Pina-D1, Pinb-D1, Gsp-A1, Gsp-B1, and Gsp-D1. Three types of null alleles were identified using diagnostic primers: the first type was a multiple deletion of Pina-D1, Pinb-D1, and Gsp-D1 (Pina-D1k), the second was a Pina-D1 deletion (Pina-D1b); and the third type was a deletion of Gsp-D1, representing a novel null allele designated here as Gsp-D1k. Sequence analysis resulted in four allelic variants at Pinb-D1 and five at Gsp-A1, among them Gsp-A1-V was novel. Pina-D1, Gsp-B1 and Gsp-D1 sequences were monomorphic. Haplotype and phylogenetic analysis suggested that (1) bread wheat inherited its 5DS telomeric region probably from wild diploid Ae. tauschii subsp. tauschii found within an area from Transcaucasia to Caspian Iran; and that (2) the Ha-A and Ha-B homoeoloci were most closely related to sequences of wild tetraploid T. dicocco ides. This study provides a good overview of available genetic diversity at Pina-D1, Pinb-D1, and Gsp-1, which can be exploited to extend the range of grain texture traits in wheat.

  12. Clinicopathologic Characteristics and Outcomes of Lupus Nephritis With Antineutrophil Cytoplasmic Antibody

    Science.gov (United States)

    Wang, Yuan; Huang, Xin; Cai, Juan; Xie, Lijiao; Wang, Weili; Tang, Sha; Yin, Shiwei; Gao, Xuejing; Zhang, Jun; Zhao, Jinghong; Huang, Yunjian; Li, Yafei; Zhang, Ying; Zhang, Jingbo

    2016-01-01

    Abstract Few studies have analyzed the clinicopathologic characteristics and outcomes of lupus nephritis (LN) patients with antineutrophil cytoplasmic antibody (ANCA). The clinical and renal histopathologic data of 154 patients with biopsy-proven LN from 2011 to 2013 were analyzed retrospectively. The patients were followed up for a median period of 16.8 ± 9.4 months, and their outcomes were analyzed. Multivariate Cox analysis was used to evaluate the independent factors for poor outcomes. Among the 154 LN patients, 26 (16.88%) were seropositive for ANCA. The incidences of alopecia, oral ulcer, photosensitivity and skin lesion, and psychosomatic manifestations in the ANCA-positive group were significantly higher than in the ANCA-negative group (P = 0.007, 0.02, 0.02, and 0.03, respectively). Compared with the ANCA-negative group, the ANCA-positive group had significantly lower levels of complement C3 (P = 0.03). Additionally, the positive rate of antinucleosome antibodies, antihistone antibodies, antimitochondrial antibody M2, and anticardiolipin antibodies were higher significantly in the ANCA-positive patients than in the ANCA-negative patients (P = 0.001, 0.001, 0.03, 0.005, respectively). The ANCA-positive group had a notably higher chronic index than the ANCA-negative group (P = 0.01). During the follow-up, the complete remission rate in the ANCA-negative group was higher than that in the ANCA-positive group (P = 0.01). The cumulative renal survival rate in the ANCA-positive group was significantly lower than in the ANCA-negative group (log-rank = 6.59, P = 0.01). Multivariate Cox analysis revealed that the reduced estimated glomerular filtration rate (HR, 1.02; 95% confidence interval, 1.01 to 1.03; P = 0.005), NLR (HR, 1.20; 95% confidence interval, 1.02 to 1.40; P = 0.03), and ANCA (HR, 3.37; 95% confidence interval, 1.12 to 10.09; P = 0.03) were independent risk factors for patients’ renal survival after

  13. Teor de nutrientes em mudas de cedro (Cedrela fissilis Vell. submetidas a doses crescentes de níquel, em solução nutritiva

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    Paiva Haroldo Nogueira de

    2002-01-01

    Full Text Available O efeito da aplicação de níquel sobre o teor de nutrientes na raiz, no caule e nas folhas de mudas de cedro (Cedrela fissilis Vell. foi estudado em um experimento realizado em casa de vegetação do Departamento de Ciência do Solo da Universidade Federal de Lavras. As mudas foram cultivadas em solução nutritiva de Clark e submetidas a doses crescentes de Ni: 0, 42, 84, 169 e 252 mimol. O experimento foi conduzido em delineamento estatístico de blocos ao acaso, e após 60 dias de exposição ao metal pesado foram feitas avaliações do teor de macro e de micronutrientes na matéria seca de raiz, caule e folha. Os resultados mostraram que a aplicação de níquel aumentou o teor de P, praticamente não afetou o teor de K e de S, no entanto reduziu o teor de Ca e de Mg. Os teores de Cu, Fe e Mn, de modo geral, sofreram redução, ao passo que o teor de Zn foi pouco afetado. O teor de Ni, na matéria seca de raiz, caule e folha, elevou-se com o aumento das doses deste metal pesado, que mostrou ser móvel nas plantas analisadas.

  14. Sinergia entre aditivo vegetal e níveis crescentes de promotores de crescimento sobre o desempenho produtivo e morfometria intestinal de frangos de corte

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    Fabiano Gomes Gonçalves

    2014-02-01

    Full Text Available Objetivou-se avaliar o efeito da adição de níveis crescentes de antibióticos associados ao farelo integral de pimenta rosa (FIPR sobre o desempenho produtivo e morfometria intestinal de frangos corte. Utilizaram-se 528 pintos Cobb, machos, distribuídos em um delineamento inteiramente casualizado, com seis tratamentos e quatro repetições de 22 animais cada, constituído pelos grupos T1 - Controle Negativo (CN - Dieta basal sem FIPR e sem antibióticos; T2 - Controle Positivo (CP - Dieta Basal com 1,2% FIPR; T3 - CP + 11ppm bacitracina zinco e 17ppm salinomicina; T4 - CP + 22ppm bacitracina zinco e 34ppm salinomicina; T5 - CP + 33ppm bacitracina zinco e 51ppm salinomicina; T6 - CP + 45ppm bacitracina zinco e 67ppm salinomicina. No período de 1-43 dias de idade, observou-se que a adição de FIPR com ou sem antibiótico reduziu (P≤0,05 o consumo e melhorou a conversão alimentar, comparado com CN. Verificou-se que os frangos alimentados com FIPR associado aos antibióticos, em valores acima de 22mg kg-1 de bacitracina de zinco e 34mg kg-1 de salinomicina, tiveram maiores alturas de vilosidades intestinais que o CN (P≤0,05. O FIPR pode ser utilizado em substituição aos antibióticos sem queda de desempenho animal e com a manutenção da viabilidade e do fator de produção.

  15. OBTENCIÓN DE BIOETANOL PRIMARIO A PARTIR DE LA BIOMASA LIGNOCELULÓSICA DEL MATE (Crescentía cujete

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    Ely Fernando Sacón Vera

    2013-12-01

    Full Text Available El objetivo de esta investigación fue obtener bioetanol a partir de la biomasa lignocelulósica del mate (Crescentía cujete. Se empleó un Diseño Completamente al Azar en arreglo bifactorial AxB con tres réplicas por cada tratamiento. Se manipularon los factores de estudio: A. Concentración de ácido sulfúrico (2.5%, 5% y 7.5% y B. Cantidad de levadura Saccharomyces cerevisiae (2 y 5 mL. Se evaluaron las variables: acidez, °Brix, Grado Gay Lussac, Azucares totales y reductores. Los resultados encontrados demostraron que la hidrólisis ácida permitió desdoblar la lignocelulosa ya que incrementaron los azúcares reductores fue de 13.82% en comparación con los encontrados en la pulpa 6.46%; de la misma forma se obtuvo mayor contenido de alcohol (20.70 GL en el tratamiento a2b2 (5% de ácido sulfúrico + 5 mL de levadura S. cerevisiae, el cual presentó menor contenido de acidez con 0.643%, los °Brix fue de 18.47, mientras que el tratamiento a2b2 presentó mayor contenido de acidez con 0.893%, el a2b1 obtuvo menor contenido de °Brix con 15.00, y el a1b1 presentó menor contenido de Grado Gay Lussac con 8.33. De esta forma se concluye que es posible obtener un alcohol primario a partir de la biomasa del mate sometido a una hidrólisis ácida al 5% y fermentación con S. cerevisiae al 2% en relación al peso de la pulpa del mate.

  16. Anadolu’da Harp Yılları, Hilal-i Ahmer Mecmuası ve Dönemin Toplumsal Sorunları /War Years in Anatolia, Red Crescent Society and Social Problems of that Period

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    HASAN KORKUT

    2013-10-01

    Full Text Available Öz 1863'de kurulan Osmanlı Hilal-i Ahmer Cemiyeti Balkan ve Birinci Dünya Savaşları’nda önemli vazifeler ifa etti. 1911-1921 arası dönem Hilal-i Ahmer Cemiyeti açısından çok önem arz etmektedir. Trablusgarp Savaşı ile başlayıp Birinci Dünya Savaşı ile sonuçlanan dönemde Osmanlı Hilal-i Ahmer Cemiyeti Osmanlı askeri kurumlarıyla işbirliği içinde önemli vazifeler görmüştür. Gerek cephedekilere ve gerek cephe gerisinde kalanlara, özellikle yaşlı, kadın ve çocuklara yaptığı yardımlar ile dönemin kanayan yaralarına merhem oldu. Esirlerle ve muhacirlerle ilgili meseleler ile çok yakından ilgilendi. Ayrıca Cemiyet toplumsal felaketler, yaygın hastalıklar ve hıfzıssıhha alanında halka önemli yardımlarda bulunmuştur. Abstract The Ottoman Red Crescent Society was established in 1863 and it carried out important functions during the Balkan and First World Wars. The period of 1911-1923 was a crucially important era for the Ottoman Red Crescent. In a period of continuing wars starting with the War of Tripoli and lasting until the end of the First World War, the Ottoman Red Crescent worked in close collaboration with the Ottoman military establishment. In addition to opening hospitals to the wounded, it also handled the complicated case of the prisoners of war. Besides these fundamental tasks, the Ottoman Red Crescent had also performed a variety of activities such as significant assistances by establishing accommodation to the refugees, women and old people. The Ottoman Red Crescent also supported population against the social disasters, common diseases and health issues.

  17. Efeito de níveis crescentes de levedura de álcool em rações contendo fígado bovino sobre a performance de larvas de jundiá (Rhamdia quelen Effect of crescent levels of yeast of alcohol used in rations containing bovine liver on larvae of (Rhamdia quelen performance

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    Rosamari Piaia

    1997-06-01

    Full Text Available O presente trabalho foi realizado com a finalidade de avaliar o efeito de diferentes níveis de levedura sobre o desempenho inicial de larvas de Rhamdia quelen durante as trêss primeiras semanas de vida. Um total de 3000 larvas foram distribuídas em quinze grupos, em um sistema de criação com reutilização de água, termoregulada. Utilizou-se cinco tratamentos com níveis crescentes de levedura (T1 - 50%, T2 - 60%, T3 - 70%, T4 - 80% e T5 - 90% em substituição ao fígado bovino fresco. Os níveis de proteína bruta (PB e energia digestível variaram de 41,36 a 26,56% de PB e 3197 a 2789kcal ED/kg. A granulometria dos alimentos testados foi de 100 a 200mi, 200 a 400mi e 400 a 600mi para as três semanas experimentais, respectivamente. O alimento foi fornecido a vontade entre 8 e 20 horas. Dentro dos limites de proteína estudados houve efeito positivo de níveis mais elevados de PB sobre os comprimentos total e padrão e peso individual. Porém houve um efeito negativo sobre a sobrevivência das larvas de jundiá Rhamdia quelen.The present study was developed with the purpose of evaluating the effects of different protein levels in initial performance of Rhamdia quelen larvae during the first three weeks of life. The sample contained 3000 larvae distributed in fifteen groups, maintained in controlled conditions of culture and utilizing termoregulatory water re-use system. Five crescent levels of yeast (T1 50%, T2 60%, T3 70%, T4 80% and T5 90% were used in rations in substituition of bovine liver. Levels of crude protein and digestible energy varied 41,36% to 26,56% CP and from 3197 to 2789 kcal ED/kg. The granulometry of tested food was of 100 a 200mu, 200 a 400mu and 400 a 600mu for three experimental weeks respectively. Food distribution provided at ease between 8 Am and 8 Pm. Within the net protein used in this research, there was found a positive effect for the highest protein levels for total, standard lenght and individual weight

  18. The nature of fracturing and stress distribution in quartzite around the 1128-M (3700-FT) level of the crescent mine, Coeur d'Alene mining district, Idaho

    Science.gov (United States)

    Miller, C.H.; Skinner, E.H.

    1980-01-01

    Silver and copper are the principal ores mined from the quartzite at the Crescent mine. Both the main ore-bearing veins and foliation in the quartzite are parallel to the nearly vertical formational contacts. Anisotropy of the quartzite is indicated by both dynamic and static tests. Disking and breakage of core from holes perpendicular to the foliation are about twice what they are in core from holes parallel to foliation. Natural cleavage as well as slabbing and blasting fractures around the tunnels are also controlled by the foliation. Extensive overcore deformation measurements indicate that most of the influence of the tunnels on the "free" stress field is between the rib and a depth of 2.7 m (1 tunnel diameter). The maximum principal stress axis in the free field is nearly horizontal; its magnitude is not much greater than the vertical component and calculations indicate a nearly hydrostatic free stress field. Stress considerably greater than the free field was measured between about 0.3-2.7 m behind the rib and is caused by a transfer of load from above the tunnel opening. Peak stress is in the vertical direction and about 1.7 m behind the rib. An air-injection survey shows that high permeabilities are confined to the highly fractured annulus around a tunnel to a depth of at least 0.6 m. Air-injection measurements could be taken in the interval of about 0.6-1.8 m, but more fractures with high permeabilities may also be present in the annulus from about 0.6-1.2 m. Permeabilities measured deeper than about 1.8 m by the air-injection technique are either very low or nonexistent. The absence of open and noncontinuous fractures beyond about 1.8 m is also indicated by very low porosities and permeabilities of core, very high stresses (which presumably would close fractures), the lack of stains or secondary fillings in disking fractures, a conspicuous lack of ground water in the tunnels, and the fact that fractures encountered in an experimental 0.9-m tunnel did not

  19. Mycorrhizal dependency of mangaba tree under increasing phosphorus levels Dependência micorrízica de mangabeira em doses crescentes de fósforo

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    Júlio Alves Cardoso Filho

    2008-07-01

    Full Text Available The objective of this study was to evaluate the mycorrhizal dependency of mangaba tree (Hancornia speciosa plantlets, under increasing levels of phosphorus fertilization. The experimental design was completely randomized in a 4×5 factorial arrangement with three mycorrhizal fungi inocula - Gigaspora margarita, Glomus etunicatum, or a pool of native mycorrhizal fungi (Acaulospora longula, Glomus clarum, Gigaspora albida, Paraglomus sp. -, and a nonmycorrhizal control, in combination with five levels of phosphorus applied to the substrate: 0, 25, 50, 75, and 100 mg kg-1. After 180 days of growth, plantlets with inoculation of native mycorrhizal pool produced more shoot and root dry biomass and had higher shoot phosphorus content and accumulation. The noninoculated control showed the lowest values, independently of the phosphorus level. The highest relative mycorrhizal dependency occurred with the inoculation of native mycorrhizal fungi. Plants with mycorrhizal fungi did not respond to phosphorus addition above 50 mg kg-1. Mangaba tree is highly dependent on mycorrhiza, but the degree of dependency varies according to phosphorus levels and fungal inocula. In general, mangaba tree is more responsive to mycorrhizal fungi inoculation than to phosphorus addition.O objetivo deste trabalho foi avaliar a dependência micorrízica de mudas de mangaba (Hancornia speciosa, em doses crescentes de fósforo. O delineamento experimental foi inteiramente casualizado, em arranjo fatorial 4´5 com três inóculos de fungos micorrízicos - Gigaspora margarita, Glomus etunicatum, ou uma mistura de espécies de fungos micorrízicos nativos (Acaulospora longula, Glomus clarum, Gigaspora albida e Paraglomus sp. -, e um controle não micorrízico, combinados a cinco doses de fósforo no substrato: 0, 25, 50, 75 e 100 mg kg-1. Após 180 dias, as mudas com inoculação dos fungos micorrízicos nativos produziram mais biomassa seca de parte aérea e raízes e apresentaram

  20. ANCA positivity in a patient with infective endocarditis-associated glomerulonephritis: a diagnostic dilemma.

    Science.gov (United States)

    Ghosh, Gopal Chandra; Sharma, Brijesh; Katageri, Bhimarey; Bhardwaj, Minakshi

    2014-09-01

    Glomerulonephritis (GN) is an immunological phenomenon in bacterial endocarditis. These may be pauci-immune/vasculitic GN, post-infective GN, and sub-endothelial membranoproliferative glomerulonephritis. Each type of glomerulonephritis usually occurs in isolation. We report a case of infective endocarditis with dual existence of pauci-immune/vasculitic GN and post infective type of GN at the same time.

  1. [An experience of treatment of double positive myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) and anti-glomerular basement membrane antibodies in Goodpasture's syndrome onset of crescentic glomerulonephritis].

    Science.gov (United States)

    Takeda, T; Takeda, T; Naiki, Y; Yonekawa, S; Sakaguchi, M; Iwamoto, I; Tanaka, H; Hasegawa, H; Imada, A; Kanamaru, A; Hiruma, S; Maekura, S; Hashimoto, S; Yamazumi, T

    1998-11-01

    A 68-year-old woman was admitted to Kinki University Hospital because of progressive renal failure. She had been well until two months before admission. Laboratory data were as follows: serum creatinine 4.1 mg/dl, BUN 69 mg/dl, MPO-ANCA 33 EU, anti-glomerular basement membrane antibodies (AGBMA) 118 U. Histological findings showed cellular and fibrocellular crescents in many glomeruli. Therefore, we diagnosed rapidly progressive glomerulonephritis (RPGN) due to MPO-ANCA and anti-GBM associated renal disease. The patient was started on prednisolone and double filtration plasmapheresis (DFPP) therapy. Subsequently, the values of MPO-ANCA and AGBMA decreased. However, the patient's condition suddenly worsened and she died of interstitial pneumonia. Autopsy examination revealed crescentic glomerulonephritis and alveolar hemorrhage with linear deposition of IgG along the glomerular and alveolar capillary walls by immunofluorescence studies. We considered this to be a rare case of Goodpasture's syndrome associated with not only anti-GBM antibodies, but also MPO-ANCA.

  2. A Case Report Describing a Rare Presentation of Simultaneous Occurrence of MPO-ANCA-Associated Vasculitis and Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Nathalie Foray

    2016-01-01

    Full Text Available Background. Renal-limited myeloperoxidase vasculitis with simultaneous rheumatoid arthritis is reported as a rare occurrence. Review of literature suggests that most patients had a diagnosis of rheumatoid arthritis for several years prior to presenting with renal failure from myeloperoxidase vasculitis. Case Presentation. A 58-year-old Caucasian male presented to the hospital experiencing malaise, fevers, decreased oral intake, nausea, and vomiting for one week duration. His past medical history consisted of newly diagnosed but untreated rheumatoid arthritis, hypertension, and non-insulin-dependent diabetes mellitus. He was found to have acute renal failure, proteinuria, and hypoglycemia. Standard therapy, including intravenous fluids, did not improve his acute renal failure. A vasculitis workup resulted in a positive myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA. Renal biopsy revealed crescentic glomerulonephritis (GN pauci-immune type, suggestive of MPO-ANCA-associated vasculitis (MPO-AAV. Treatment consisted of prednisone, cyclophosphamide, and seven cycles of plasmapheresis, in addition to hemodialysis for uremia. Upon discharge, he received hemodialysis for another week and continued treatment with cyclophosphamide and prednisone. Conclusion. Patients with longstanding rheumatoid arthritis may develop renal failure due to nonsteroidal anti-inflammatory medication use and AA type amyloidosis; however, necrotizing glomerulonephritis with crescent formation has been rarely reported. This stresses the importance of early recognition and swift initiation of treatment.

  3. Salvia divinorum Epling & Játiva (Maria Pastora e Salvinorina A: crescente uso recreacional e potencial de abuso Salvia divinorum Epling & Játiva ("ska María Pastora" and Salvinorin A: increasing recreational use and abuse potential

    Directory of Open Access Journals (Sweden)

    R.J. Schneider

    2010-09-01

    Full Text Available A planta Salvia divinorum Epling & Játiva (SDI, da família Lamiaceae, tem sido usada por séculos pela cultura mazateca e vem ganhando popularidade como droga recreacional nos últimos anos. Seu princípio ativo - Salvinorina A (SA - é agonista dos receptores opióides kappa, com potencial psicotrópico. A utilização da planta vem crescendo na Europa e na América do Norte, apesar de ainda não existirem provas concretas sobre abuso. A presente revisão da literatura contemporânea aborda as evidências sobre o potencial de abuso de SDI, bem como o crescente uso recreacional, ainda que seja alucinógeno permitido legalmente e de fácil compra em muitos países.The plant Salvia divinorum Epling & Játiva (SDI, of the Lamiaceae family, has been used for centuries by the Mazateca culture and has gained popularity as a recreational drug in the last years. Its active principle, Salvinorin A (SA, is a potentially psychotropic agonist of the kappa opioid receptors. The use of SDI has increased in Europe and North America, although there are no concrete proofs about abuse. The present review discusses current evidence on potential SDI abuse, as well as its increasing recreational use, although it is considered a legalized hallucinogen easily acquired in many countries.

  4. Biodisponibilidade do P e digestibilidade aparente do N em dietas de suínos suplementadas com níveis crescentes de fitase, balanceadas de acordo com o conceito de proteína ideal

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    J.A. Moreira

    2011-12-01

    Full Text Available Avaliaram-se o efeito de inclusão crescente de fitase (unidade de fitase - UF em dietas para suínos na fase de crescimento pela técnica de diluição isotópica. Foram utilizados 20 suínos, machos castrados, em delineamento de blocos ao acaso, com cinco tratamentos - 0, 250, 500, 750 e 1000UF/kg da ração - e quatro repetições. Os animais foram alojados em gaiolas metabólicas por 17 dias, sendo 10 dias para adaptação e sete dias para coleta de fezes e urina. Amostras de sangue foram coletadas por cinco dias. No primeiro dia da fase experimental, cada animal recebeu por via endovenosa em solução radioativa com 7,4MBq de 32P. A Quantum Phytase foi eficiente em disponibilizar o P fítico para suínos em crescimento até 750UF/kg de dieta, sendo que 500UF/kg da ração foi o indicado para dietas à base de milho e farelo de soja, formuladas de acordo com o conceito de proteína ideal.

  5. THE HELPS WHICH WERE MADE BY THE RED CRESCENT IN ANATOLIA AND GREECE TO THE TURKS AND GREEK PRISONERS IN THE PERIOD OF THE NATIONAL STRUGGLE / MILLI MÜCADELE DÖNEMINDE HILAL-I AHMER CEMIYETI’NIN ANADOLU VE YUNANISTAN’DAKI TÜRK VE YUNAN ESIRLERINE YAPTIĞI YARDIMLAR

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    Dr. Erol KAYA

    2008-05-01

    Full Text Available It became mutually the prisoners of war to the Grek and Turkishunions fighting in Anatolia during the First World War. It was helped in thedifferent was both The Grek prisoners in Anatolia and The Turkish prisonersin Greece by The Red Crescent. These helpings were rather important fromthe point of view of improvement of the positions of The Turkish prisoners inGrece especially.

  6. Alterações hematológicas e cardíacas em cavalos Árabes submetidos ao teste de esforço crescente em esteira rolante

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    Guilherme de Camargo Ferraz

    2009-12-01

    Full Text Available Estudaram-se alterações na freqüência cardíaca e variáveis hematológicas de eqüinos Puro Sangue Árabe (PSA, submetidos a exercício intenso em esteira rolante sob condições tropicais. Para tanto, 24 eqüinos, treinados, realizaram exercício teste de intensidade crescente e amostras de sangue foram obtidas durante as etapas de esforço 4; 5; 6; 7; 8; 9 e 10 m.s-1, com 10% de inclinação. As colheitas de sangue foram realizadas 15 segundos antes do término de cada etapa. A freqüência cardíaca foi obtida em cada etapa do exercício teste. Com as amostras de sangue foram obtidos, hematócrito, hemácias, hemoglobina e leucócitos totais. Foram calculados índices hematimétricos absolutos, volume corpuscular médio (VCM, hemoglobina corpuscular média (HCM e a concentração de hemoglobina corpuscular média (CHCM. Os resultados mostram que houve variação significativa (p < 0,05, a partir do repouso, entre os valores médios da freqüência cardíaca e das variáveis hematimétricas. Destaque para o VCM e HCM que aumentaram significativamente (p < 0,05 na etapa de esforço máximo (10m/s demonstrando haver anisocitose durante o exercício intenso. Desta forma, o grau das alterações destas variáveis fisiológicas está relacionado com a intensidade e duração do exercício teste.

  7. Significance of CD163-Positive Macrophages in Proliferative Glomerulonephritis.

    Science.gov (United States)

    Li, Jun; Liu, Chang-Hua; Xu, Dao-Liang; Gao, Bo

    2015-11-01

    CD163, a marker of M2 macrophages, possesses anti-inflammatory properties. This study aims to investigate the clinicopathological significance of CD163-positive macrophages in proliferative glomerulonephritis. Renal tissue samples from patients with lupus nephritis (LN, n = 22), antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune necrotizing glomerulonephritis (PNGN, n = 10), type 1 membranoproliferative glomerulonephritis (n = 5), minimal change disease (n = 8) and normal control kidneys (n = 3) were included in this study. The expression of CD163, CD68, CD20 and CD3 in renal tissues was detected by immunohistochemistry or immunofluorescence. The level of urinary neutrophil gelatinase-associated lipocalin (NGAL) was determined by enzyme-linked immunosorbent assay. CD163 was mainly expressed in active crescentic glomerulonephritis, proliferative glomerular lesions and areas of tubulointerstitial injury. Patients with LN-IV and PNGN had numerous CD163-positive cells in glomerular and acute tubulointerstitial lesions. CD163-positive cells in glomeruli positively correlated to proteinuria yet negatively correlated to estimated glomerular filtration rate. There was a positive correlation between the number of CD163 cells in acute tubulointerstitial lesions and NGAL levels, whereas a negative correlation between CD163 numbers and estimated glomerular filtration rate. The number of CD163-positive cells in crescentic glomerulonephritis was more than other groups. In LN, the number of CD163 cells in the tubulointerstitial and glomerular lesions had a positive correlation with activity index. Dual staining showed that CD163-positive cells also expressed CD68, although they did not show any staining for CD20 or CD3. CD163-positive macrophages were involved in the pathogenesis of proliferative glomerular lesions, active crescentic glomerulonephritis and acute tubular injury of patients with PNGN and active LN.

  8. D-penicillamine-induced ANA (+) ANCA (+) vasculitis in pediatric patients with Wilson's disease.

    Science.gov (United States)

    Lee, Yeonhee; Lee, Sang Taek; Cho, Heeyeon

    2016-05-01

    Anti-neutrophil cytoplasmic antibodies (ANCA) are associated with systemic vasculitis. The pathophysiology of ANCA-associated vasculitis (AAV) has not been clearly proven, and drug-induced ANCA-associated vasculitis has been reported. Wilson's disease is an inborn error of copper metabolism caused by a mutation in the copper transporting gene ATP7B, and traditional treatment is based on copper chelation with agents such as D-penicillamine. There have been rare reports that prolonged D-penicillamine therapy might cause adverse renal events such as membranous nephropathy and minimal change disease, but it is questionable if D-penicillamine induces ANCA-associated vasculitis. We describe 2 patients with Wilson's disease treated with D-penicillamine who presented with ANCA (+) vasculitis and renal involvement. The 2 patients also showed positive results for antinuclear antibody (ANA). Their kidney biopsy findings were compatible with crescentic/necrotizing glomerulonephritis, pauci-immune type. After diagnosis of AAV, D-penicillamine was stopped. Patients were then treated with plasmapheresis and immunosuppressants, including methylprednisolone pulse therapy and intravenous cyclophosphamide. One patient progressed to end-stage renal disease and the other showed persistent proteinuria. These cases suggest that D-penicillamine may induce ANA (+) ANCA (+) vasculitis with severe renal involvement in pediatric patients, and plasmapheresis combined with immunosuppressant should be considered.

  9. A case of exorbitism in association with Wegener's granulomatosis with renal involvement.

    Science.gov (United States)

    Beji, S; Fatma, L Ben; Chebbi, A; Rais, L; Krid, M; Smaoui, W; Maiz, H Ben; Zouaghi, K; Moussa, F Ben

    2012-03-01

    Wegener's granulomatosis (WG) is a necrotizing granulomatous vasculitis involving the nose, paranasal sinuses, lungs, and kidneys. Ocular involvement can occur in about 50% of cases. There are very few reports of WG with orbital inflammation and exorbitism. We report a case of a female patient who presented with exorbitism related to orbital inflammation secondary to WG, with renal involvement. A 29-year-old woman with a previous history of recurrent pan-sinusitis presented with bilateral exophthalmos and renal failure with rapidly progressive glomerulonephritis. Computed tomography showed extensive bilateral soft tissue in the retro-orbital area. Immunologic tests showed the presence of type-C anti-neutrophil cytoplasmic antibodies and renal biopsy revealed pauci immune crescentic glomerulonephritis. The patient was treated with corticosteroids and pulses of cyclophosphamide followed by azathioprine and trimethoprim-sulfamethoxazole. After a follow-up of 10 months, the renal outcome was favorable with improvement of renal function but there was persistence of exorbitism and loss of visual function. Our case suggests that WG should be considered in the differential diagnosis of persistent bilateral exophthalmos. Prompt recognition of this early manifestation is important for the institution of early treatment.

  10. Kaposi's sarcoma with HHV8 infection and ANCA-associated vasculitis in a hemodialysis patient.

    Science.gov (United States)

    Fatma, Lilia Ben; Rais, Lamia; Mebazza, Amel; Azzouz, Haifa; Beji, Somaya; Krid, Madiha; Smaoui, Wided; Maiz, Hedi Ben; Zouaghi, Karim; Zitouna, Moncef; Osmane, Amel Ben; Moussa, Fatma Ben

    2013-11-01

    The association between Kaposi's sarcoma (KS) and human herpes virus eight (HHV-8) infection is rarely reported in hemodialysis (HD) patients. We report here the rare association of KS, HHV-8 and hepatitis C virus (HCV) infection as well as syphilis in a HD patient. We report the case of a 72-year-old woman who presented with microscopic polyangiitis with alveolar hemorrhage and pauci-immune necrosing and crescentic glomerulonephritis as well as renal failure requiring HD. Biological tests showed positive HCV and syphilis tests. The patient was treated by HD and intravenous pulse, followed by oral corticosteroids and six cyclophosphamide monthly pulses with remission of the alveolar hemorrhage, but without renal functional recovery as the patient remained HD dependent. Five months after the first treatment administration, she developed extensive purpuric lesions on her lower limbs, abdomen face and neck. A skin biopsy showed KS. The HHV-8 test was positive, with positive polymerase chain reaction-HHV8 in the serum and skin. After immunosuppression withdrawal, the KS skin lesions regressed rapidly without relapse after 12 months of follow-up, but alveolar hemorrhage relapsed after 16 months of follow-up. Our case showed that the immunosuppressed state related to multiple factors such as aging, vasculitis, HHV-8, HCV, syphilis, immunosuppressive therapy and HD may all have contributed to the development of KS in our patient.

  11. A case of exorbitism in association with Wegener′s granulomatosis with renal involvement

    Directory of Open Access Journals (Sweden)

    S Beji

    2012-01-01

    Full Text Available Wegener′s granulomatosis (WG is a necrotizing granulomatous vasculitis invol-ving the nose, paranasal sinuses, lungs, and kidneys. Ocular involvement can occur in about 50% of cases. There are very few reports of WG with orbital inflammation and exorbitism. We report a case of a female patient who presented with exorbitism related to orbital inflammation secondary to WG, with renal involvement. A 29-year-old woman with a previous history of recurrent pan-sinusitis presented with bilateral exophthalmos and renal failure with rapidly progressive glo-merulonephritis. Computed tomography showed extensive bilateral soft tissue in the retro-orbital area. Immunologic tests showed the presence of type-C anti-neutrophil cytoplasmic antibodies and renal biopsy revealed pauci immune crescentic glomerulonephritis. The patient was treated with corticosteroids and pulses of cyclophosphamide followed by azathioprine and trimethoprim-sulfamethoxazole. After a follow-up of 10 months, the renal outcome was favorable with improvement of renal function but there was persistence of exorbitism and loss of visual function. Our case suggests that WG should be considered in the differential diagnosis of persistent bila-teral exophthalmos. Prompt recognition of this early manifestation is important for the institution of early treatment.

  12. Kaposi′s sarcoma with HHV8 infection and ANCA-associated vasculitis in a hemodialysis patient

    Directory of Open Access Journals (Sweden)

    Lilia Ben Fatma

    2013-01-01

    Full Text Available The association between Kaposi′s sarcoma (KS and human herpes virus eight (HHV-8 infection is rarely reported in hemodialysis (HD patients. We report here the rare association of KS, HHV-8 and hepatitis C virus (HCV infection as well as syphilis in a HD patient. We report the case of a 72-year-old woman who presented with microscopic polyangiitis with alveolar hemorrhage and pauci-immune necrosing and crescentic glomerulonephritis as well as renal failure requiring HD. Biological tests showed positive HCV and syphilis tests. The patient was treated by HD and intravenous pulse, followed by oral corticosteroids and six cyclophosphamide monthly pulses with remission of the alveolar hemorrhage, but without renal functional recovery as the patient remained HD dependent. Five months after the first treatment administration, she developed extensive purpuric lesions on her lower limbs, abdomen face and neck. A skin biopsy showed KS. The HHV-8 test was positive, with positive polymerase chain reaction-HHV8 in the serum and skin. After immunosuppression withdrawal, the KS skin lesions regressed rapidly without relapse after 12 months of follow-up, but alveolar hemorrhage relapsed after 16 months of follow-up. Our case showed that the immunosuppressed state related to multiple factors such as aging, vasculitis, HHV-8, HCV, syphilis, immunosuppressive therapy and HD may all have contributed to the development of KS in our patient.

  13. A Challenging Twist in Pulmonary Renal Syndrome

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    Rajaie Namas

    2014-01-01

    Full Text Available Case. We report a rare case of hydralazine-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. A 75-year-old African American woman with history of high blood pressure on hydralazine for 3 years presented with acute onset of shortness of breath and hemoptysis. Lab workup revealed a severe normocytic anemia and a serum creatinine of 5.09 mg/dL (baseline 0.9. Bronchoscopy demonstrated active pulmonary hemorrhage. A urine sample revealed red cell casts and a renal biopsy demonstrated pauci-immune, focally necrotizing glomerulonephritis with small crescents consistent with possible anti-neutrophil cytoplasmic antibody-positive renal vasculitis. Serologies showed high-titer MPO-ANCA and high-titer anti-histone antibodies. She was treated with intravenous steroids and subsequently with immunosuppression after cessation of hydralazine. The patient was subsequently discharged from hospital after a rapid clinical improvement. Conclusion. Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis is a rare adverse effect and can present as a severe vasculitic syndrome with multiple organ involvement. Features of this association include the presence of high titer of anti-myeloperoxidase anti-neutrophil cytoplasmic antibody with multiantigenicity, positive anti-histone antibodies, and the lack of immunoglobulin and complement deposition. Prompt cessation of hydralazine may be sufficient to reverse disease activity but immunosuppression may be needed.

  14. Post-transplant immune complex nephritis in a patient with systemic lupus erythematosus associated with ANCA vasculitis.

    Science.gov (United States)

    Sanchez, Carlos; Rebolledo, Alejandra; Gahona, Junior; Rojas, Mauricio; Jiménez, Raquel; Bojórquez, Aurora

    2017-01-29

    Nearly 20% of SLE corresponds to the pediatric population, and 75% of them have kidney involvement representing an important etiology of chronic kidney disease. A correlation between SLE and ANCA-associated vasculitis has been identified as an overlapping syndrome. Kidney allograft recurrence is rare in SLE when disease control is achieved and with nowadays immunosuppression treatment. Histologic transformation is unusual, especially when there are negative serologic markers and no immune complex deposition reported in native kidneys. A 17-year-old female with crescentic glomerulonephritis, p-ANCA-positive antibodies with pauci-immune pattern in kidney biopsy develops end-stage renal disease requiring hemodialysis. Deceased donor kidney transplant was performed receiving triple immunosuppression thereafter. Thirteen months later serum creatinine rises without evidence of infection, urinary obstruction, or clinical and serologic disease relapse. Allograft biopsy reports mesangial proliferation and "full-house" immunofluorescence. The role of ANCA in SLE physiopathology is controversial, and its relation with lupus nephritis is also discordant. ANCA could represent an important factor in the heterogeneity of systemic lupus erythematosus and lupus nephritis.

  15. Crescent City, California Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) for select U.S. coastal regions. These integrated...

  16. Scleroderma with crescentic glomerulonephritis: a case report

    OpenAIRE

    Ramaswami Arunachalam; Kandaswamy Thiraviam; Rajendran Tholappan; Jeyakrishnan Kizhake; Aung Hla; Iqbal Mohammaed; Jacob Chakko K; Zinna Haji; Kafeel Gazala

    2008-01-01

    Abstract Introduction Systemic sclerosis or scleroderma is an autoimmune rheumatic disease characterized by organ-based fibrosis. Renal involvement in scleroderma occurs mainly in the form of scleroderma renal crisis, affecting 5 to 10% of patients. It remains one of the most important and immediately life-threatening complications of scleroderma, but the prognosis improves considerably after treatment with angiotensin-converting enzyme inhibitors. Other renal pathologies can occur in sclerod...

  17. Rice seedling and plant development as affected by increasing rates of penoxsulam under controlled environments Desenvolvimento de plântulas e plantas adultas de arroz em função de doses crescentes de penoxsulam em ambiente controlado

    Directory of Open Access Journals (Sweden)

    G. Concenço

    2006-01-01

    Full Text Available Rice is a major staple in many countries. Weed control is one of the factors limiting higher rice yield. ALS (acetolactate synthase-inhibiting herbicides are desirable weed control herbicides because of their high efficacy, low toxicity to mammalians, and low rates used. An important herbicide characteristic is high selectivity to the crop, since it facilitates fast crop establishment and greater crop advantage over the weeds. The objectives of this work were to study the effects of increasing rates of the ALS-inhibiting herbicide penoxsulam on seed integrity and germination, and seedling and plant development of rice cv. BRS Pelota under controlled laboratory and greenhouse conditions. The results showed that penoxsulam affected rice germination and seedling and plant growth at rates above 54 g a.i. ha-1, and that penoxsulam is safe for rice seedling development at the currently recommended rates.O arroz é componente importante da dieta humana em vários países. Entre os fatores que limitam o aumento na sua produtividade está o controle de plantas daninhas. Os herbicidas inibidores da ALS (acetolactato sintase são preferidos em razão da alta eficiência no controle de plantas daninhas, da baixa toxicidade aos mamíferos e das baixas doses utilizadas. Uma característica importante que um herbicida deve possuir é a alta seletividade à cultura, pois ela implica estabelecimento mais rápido, com vantagem competitiva sobre as plantas daninhas. O objetivo deste trabalho foi estudar os efeitos do herbicida inibidor da ALS penoxsulam em doses crescentes sobre a integridade e germinação das sementes, bem como sobre o desenvolvimento inicial das plântulas e da planta adulta do cultivar BRS Pelota, sob condições de ambiente controlado (laboratório e casa de vegetação. Os resultados mostraram que o penoxsulam afetou a germinação e o crescimento de plântulas e plantas adultas nas doses acima de 54 g i.a. ha-1 e que ele é seguro para o

  18. 一种月牙形缝隙多频微带天线分析与设计%Analysis and design of a multi-frequency microstrip antenna with crescent-shaped slot

    Institute of Scientific and Technical Information of China (English)

    缪洁; 徐文龙; 徐冰俏; 尤佳迪

    2015-01-01

    提出了一种微带馈电式圆形微带天线设计方案,通过在辐射贴片表面加载月牙型缝隙,改变电流有效路径,实现多频特性。通过HFSS仿真分析缝隙形状对天线性能的影响。结果表明,天线工作的三个频段相对带宽分别为4.1%(2.39~2.49 GHz),3.98%(3.92~4.08 GHz)和3.75%(5.51~5.72 GHz)。其中低频和中频段的最高增益达到6.58 dB和5.01 dB。天线尺寸为35 mm×52 mm,具有小体积、高增益、全向性良好的特点,能够应用于无线通信系统中,并且这种结构简单、参数少、多频段的设计方法为天线设计提供了新的途径。%A design of circular microstrip antenna with microstrip feed was presented. By loading crescent-shaped slot, the current effective length was changed and the antenna obtained the multi-frequency characteristics. The slot’s impact on performance of antenna was analyzed by HFSS software simulation. Three relative bandwidths are 4.1% (2.39-2.49 GHz), 3.98% (3.92-4.08 GHz) and 3.75% (5.51-5.72 GHz), respectively. And the maximum gain of low frequency and mid-frequency are up to 6.58 dB and 5.01 dB. The antenna has a dimension of 35 mm×52 mm and the characteristics of small volume, high gain and omni direction. It can be applied in wireless communication system. Moreover, this multi-frequency design with simple structure and less parameters provides a new way for antenna designs.

  19. TEXTURA DE FEIJÃO-VAGEM (Phaseolus vulgaris L PROCESSADO OU NÃO: EFEITO DA APLICAÇÃO DE CONCENTRAÇÕES CRESCENTES DE CÁLCIO VIA ABSORÇÃO RADICULAR

    Directory of Open Access Journals (Sweden)

    Simone Palma FÁVARO

    1998-05-01

    Full Text Available Esta investigação teve como objetivo estudar o efeito do cultivo de feijão-vagem com doses crescentes de cálcio na textura das vagens antes e após processo de enlatamento. O experimento foi desenvolvido com a cultivar UEL 1, utilizando-se areia grossa como substrato. Os tratamentos constaram das seguintes concentrações de cálcio em solução nutritiva: 0, 75, 150 e 300 ppm. Foram determinados os teores de cálcio das vagens in natura, substâncias pécticas e textura das vagens in natura e processada. As concentrações de cálcio nas vagens aumentaram em paralelo à elevação dos níveis de cálcio adicionados à solução nutritiva. Os teores de pectina solúvel nas vagens in natura não diferiram entre os tratamentos. Houve um acréscimo da quantidade de pectina insolúvel em função do aumento das doses de cálcio. Após o processamento térmico ocorreu uma solubilização das pectinas. A maior concentração de pectina solúvel nas vagens enlatadas foi observada nas vagens cultivadas sem adição de cálcio na solução nutritiva. As medidas de textura demonstraram uma tendência de aumento de firmeza das vagens concomitante à elevação nos teores de cálcio antes e após o processo de enlatamento.This study aimed to investigate the effect of increasing calcium concentrations applied in nutrient solution in snap beans. Snap beans of cultivar UEL 1 were grown in coarse sand with nutrient solution supplying calcium at the following levels: 0, 75, 150 and 300 ppm. Fresh pods were analysed for calcium content. Fresh and processed pods were analysed for pectin content and texture. The calcium concentration in bean pods was increased when the calcium level in the nutrient solution was raised. There was no difference among the treatments for content of soluble pectins, however the content of insoluble pectins raised when calcium was added to the nutrient solution. An increasing in the content of soluble pectin was observed after the

  20. Autoimmune Disease

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    2007159 Acute kidney injury of systemic sclerosis: scleroderma renal crisis and crescentic glomerulonephritis. LIU Dongyan(刘冬妍), et al. Dept Nephrol, PUMC Hosp, CAMS & PUMC, Beijin 100730. Chin J Nephrol 2007;23(4):209-203. Objective To explore the clinicopathological characteristics of acute kidney injury (AKI) of systemic sclerosis (SSc). Methods A retrospective study was performed on 11 SSc patients with AKI. The clinical data were analyzed and the patients were divided into antineutrophil cytoplasmic antibodies (ANCA) negative group(n=9) and ANCA positive(n=2) group. Results In the ANCA negative group, 2 cases were without malignant hypertension, 1 was acute tubular necrosis(ATN) caused by herbs, 6 were scleroderma renal crisis(SRC), including 4 with renal biopsy, indicating hypertrophic arterial media, edema, thickened intima, onion-skin lesion in interlobular arteries and afferent arterioles, as well as ischemic lesion in glomeruli. In the MPO-ANCA positive group, 1 was crescentic glomerulonephritis. Malignant hypertension was not noticed. All patients were given steroid, 8 of them received CTX in addition. Nine patients received dialysis, and 8 cases progressed to permanent hemodialysis. Six cases with SRC were given high dose ACEI and / or ARB. Six patients resulted in early death. Conclusion Scleroderma renal crisis and ANCA associated vasculitis may cause AKI in SSc patients. Patients with positive ANCA differ from those with negative ANCA in terms of clinical manifestation, pathology and treatment. Survival and prognosis of SSc patient were bad. High dose corticosteroids increases the risk of scleroderma renal crisis, so it is thereby recommended that the dose above 15 rog/day should be avoided if possible.

  1. Information on Dams: recalibration of the spillway of the Crescent dam. Dams life. Security and exploitation of dams: the Montezic facility, management of an incident on the pond embankment (part. 2). Activities of the control services; Information sur les barrages: recalibrage de l'evacuateur de crues du barrage de Crescent. La vie des barrages. Securite et exploitation des barrages: amenagement de Montezic, gestion d'un incident sur la digue de l'Etang (2. partie). Activites des services du controle

    Energy Technology Data Exchange (ETDEWEB)

    Charpentier, B. [Direction regionale de l' industrie, de la recherche et de l' environnement, (DRIRE), 21 - Dijon (France); Oberle, J.M. [Electricite de France (EDF - CIH), 68 - Mulhouse (France); Hoonakker, M. [Bureau d' Etude Technique et de Controle des Grands Barrages, BETCGB (France)

    2002-07-01

    This issue of Barrages newsletter comprises four articles. The first article describes the recalibration works of the spillway of the Crescent dam (Morvan, France) in order to adapt its capacity to the results of the recent hydrological studies. The second article summarizes the conclusions of the decennial, annual and other periodicity inspections of French dams. Only the observations requiring a special follow up are reported. The third article is the second part of a study about the management of an incident discovered on the embankment of the reservoir of the Montezic dam (Aveyron, France). This part describes the causes of the crack, the evolution of the leaks and the remedial actions carried out. The last article summarizes the activities of the control services (important facts, administrative instructions, studies, projects, works, meetings, workshops etc.). (J.S.)

  2. Desempenho de cordeiros alimentados com silagem de girassol ou de milho com proporções crescentes de ração concentrada Performance of sheep fed sunflower silage or corn silage with increasing proportion of commercial concentrate

    Directory of Open Access Journals (Sweden)

    Mauro Sartori Bueno

    2004-12-01

    Full Text Available Foram realizados dois experimentos com o objetivo de avaliar o valor nutritivo de dietas à base de silagens de milho ou de girassol e o desempenho de ovinos alimentados com estas dietas acrescidas de níveis crescentes de concentrado comercial (20, 40 e 60%. Para avaliação do valor nutritivo e dos coeficientes de digestibilidade aparente dos nutrientes, utilizou-se delineamento em esquema fatorial (2x3, duas silagens e três proporções de ração comercial, com três ovinos por tratamento. Para avaliação do desempenho de cordeiros, o ensaio foi em blocos ao acaso, em esquema fatorial 2x3 (duas silagens e três proporções de ração comercial, com cinco cordeiros por tratamento. Os coeficientes de digestibilidade aparente de MS, MO, FB, ENN, FDN, FDA e de celulose foram menores para as dietas à base de silagem de girassol. As dietas com silagem de milho apresentaram maiores valores de ingestão diária de matéria seca (709,5 x 609,7 g e ganho diário de peso vivo (181,8 x 108,2 g e menores de conversão alimentar (3,82 x 5,35 kg de MS/kg de ganho de PV que as de girassol. As dietas à base de silagem de girassol apresentaram valor nutritivo inferior às de silagem de milho, o que acarretou pior desempenho dos cordeiros. Os animais alimentados com dietas à base de silagem de girassol necessitam de maior quantidade de ração concentrada para obterem desempenho similar aos alimentados com silagem de milho.Two experiments were conduct to evaluate the effect of dietary nutritive value and performance of sheep fed corn- or sunflower silage-based diet with increasing concentrate proportion (20, 40 and 60%. A factorial design (2x3 was used to evaluate nutritive value and digestibility coefficient of two silages with three concentrate levels and three sheep for each treatment. For lamb performance, a randomized block design in a factorial arrangement (2x3 was used to evaluate lamb performance, with five Suffolk lambs/treatment. Apparent

  3. NUTRITIONAL PARAMETERS OF TANZANIA GRASS IN DIFFERENT CUTTING AGE UNDER NITROGEN DOSES PARÂMETROS NUTRICIONAIS DO CAPIM-TANZÂNIA SOB DOSES CRESCENTES DE NITROGÊNIO EM DIFERENTES IDADES DE CORTE

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    Eliane Sayuri Miyagi

    2007-12-01

    Full Text Available

    The objective this experiment was to evaluate the chemical composition and in vitro dry matter digestibility of Tanzania grass under increasing nitrogen levels in different cutting ages, under irrigation. The treatments were three N levels (ammonium sulphate: 200, 400 and 600 kg.ha-1 for year and four cutting ages: 28; 56; 84 and 112 days. A randomized complete blocks design in factorial 3x4 arrangement (three N levels and four cutting ages, with three repetitions was used. The analyses were accomplished using the sta-tistical System of Analysis of Variance of Data Balanced (SISVAR program. The DM tenors didn’t differ (P<0.05 among the cutting ages, except to the 112 days of increasing. Among the N levels the DM tenors differed (P<0.05 with the equivalent application to 400 and 600 kg.ha-1 of N. The CP (P>0.05 didn’t differ among the cutting ages, however they differed (P<0.05 among the N leves appraised. The NDF ADF and IVDMD didn’t differ (P>0.05 among the cutting ages, except the 112 days, however, they differed among the N levels applied.KEY-WORDS: Chemical composition, in vitro dry matter digestibility, nitrogen fertilization.

    Avaliou-se a composição químico-bromatológica e a digestibilidade in vitro da matéria seca do capim-tanzânia submetido a doses crescentes de nitrogênio em diferentes idades de corte, sob irrigação. Os tratamentos foram constituídos por três doses de N (sulfato de amônio: 200, 400 e 600 Kg/ha/ano, e quatro idades de cortes: 28; 56; 84 e 112 dias. Utilizou-se o delineamento experimental de blocos ao acaso em esquema fatorial 3x4 (três doses de nitrogênio x quatro idades de cortes com três repetições. Realizaram-se as análises mediante a  utilização do programa estatístico Sistema de Análise de Variância de Dados Balanceado (SISVAR. Os teores de MS não diferiram (P<0,05 entre as idades de corte, exceto aos 112 dias de

  4. Efeitos de dietas com níveis crescentes de milho no metabolismo ruminal de energia e proteína em bubalinos Effects of diets with increasing corn levels on the ruminal energy and protein metabolism in buffalo

    Directory of Open Access Journals (Sweden)

    Teresa Cristina Alves

    2009-10-01

    Full Text Available Avaliaram-se os efeitos de dietas com níveis crescentes de milho em grão moído (0, 22, 37 e 49% na MS em substituição ao feno de coast-cross mantendo-se diferentes relações proteína:carboidratos não-fibrosos (PB:CNF = 1,01; 0,39; 0,33 e 0,27 sobre o metabolismo ruminal de búfalos. Utilizaram-se quatro búfalos fistulados no rúmen, mantidos em delineamento quadrado latino 4 × 4, para a coleta de amostras do líquido ruminal, colhidas em cada período experimental (de 28 dias nos tempos 0, 2, 4 e 8 horas após a alimentação. Em geral, os bubalinos apresentaram boa capacidade tamponante no rúmen, com pH médio alto (6,70 e aumento da ingestão de milho em grão moído. O acréscimo nos níveis de milho na dieta promoveu aumento da produção de ácido butírico. Somente a dieta com 49% de milho promoveu melhor fermentação ruminal, com menor propoção de ácidos acético:propiônico. A relação PB:CNF de 1,01 indica deficiência de energia da dieta disponível para microrganismos no rúmen ao longo do dia, enquanto dietas com PB:CNF entre 0,39 e 0,27 promovem fermentações ruminais semelhantes, o que indica sincronismo na utilização de nitrogênio e energia pelos microrganismos no rúmen nessas condições.The effects of diets with increasing ground corn grain levels (0, 22, 37 and 49% in the dry matter substituting coast-cross hay, with different protein:non-fibrous carbohydrate ratios (CP:NFC = 1.01; 0.39; 0.33 and 0.27 were assessed on buffalo ruminal metabolism. Four rumen fistulated buffaloes were used kept in a 4 × 4 latin square design, to collect liquid ruminal samples, collected in each experimental period (28 days at 0, 2, 4 and 8 hours after feeding. In general, the buffalo presented good buffering capacity in the rumen, with high mean pH (6.70 and increase in ground corn intake. The increase in the corn levels in the diet resulted in increased butyric acid production. Only the diet with 49% corn showed better

  5. Comportamento ingestivo diurno de novilhos Nelore recebendo níveis crescentes de suplementação em pastejo de capim-braquiária Diurnal ingestive behavior of Nellore steers receiving increasing levels of supplement in brachiaria pasture

    Directory of Open Access Journals (Sweden)

    Robério Rodrigues Silva

    2010-09-01

    Full Text Available Objetivou-se avaliar o comportamento ingestivo diurno de novilhos em pastagem de capim-braquiária submetidos a suplementação energética e proteica. Foram utilizados 40 novilhos Nelore, com peso inicial de 373,7 ± 14,9 kg e 26 meses de idade, distribuídos em quatro níveis de suplementação: mistura mineral, 0,3; 0,6 e 0,9% do peso vivo de suplementação energética e proteica. Os animais foram observados visualmente por dois períodos de 12 horas; das 6 às 18 h. Os tempos de pastejo, ruminação e ócio sofreram efeito quadrático, e o tempo de cocho efeito linear crescente. Os consumos de matéria seca total não foram alterados pelos níveis de suplementação. O consumo total de matéria seca oriunda da pastagem e todas variáveis relacionadas à fibra em detergente neutro e fibra em detergente ácido decresceram linearmente. O número de mastigações por bolo decresceu linearmente. O número de períodos de pastejo e o tempo por período de cocho aumentaram linearmente. O tempo por período de pastejo decresceu linearmente. O número de períodos de ruminação, número de períodos de ócio e tempo por período de ruminação sofreram efeito quadrático. O número de períodos de cocho sofreu efeito cúbico. A suplementação compromete as variáveis relacionadas ao comportamento ingestivo diurno, não só pela quantidade de alimento ingerido, mas também por sua composição e pela razão volumoso:concentrado, portanto, exige atenção no balanceamento de rações.The objective this study was to evaluate the diurnal ingestive behavior of Nellore steers on Brachiaria grass pasture submitted to protein and energy supplementation. It was used 40 Nellore steers, at initial weight of 373.7 ± 14.9 kg, and at 26 months of age, distributed in four levels of supplementation:mineral mixture, 0.3, 0.6 and 0.9% of body weight of energy and protein supplementation. The animals were visually observed by two 12-hour periods from 6:00 a.m. to

  6. EFEITO DE DOSES CRESCENTES DE CALCÁRIO SOBRE A POPULAÇÃO DE Heterodera glycines EM SOJA EFFECT OF SOIL LIMING ON Heterodera glycines POPULATION IN SOYBEAN

    Directory of Open Access Journals (Sweden)

    Guilherme Porta Cattini

    2007-09-01

    Full Text Available

    Este estudo foi conduzido sob condições de estufa de produção, visando avaliar o efeito de doses crescentes de calcário, sobre a população do nematóide Heterodera glycines em raízes de soja. Tomando como base a recomendação de calcário para elevar a saturação de bases para 50%, adotaram-se cinco tratamentos: testemunha (sem calcário; metade da dose recomendada (0,675 t.ha-1; dose recomendada (1,35 t.ha-1; dobro da recomendação (2,7 t.ha-1; e triplo da recomendação (4,05 t.ha-1. O delineamento experimental foi inteiramente casualizado com seis repetições. O ensaio foi conduzido em vasos usando como planta hospedeira a soja, cultivar FT-Cristalina, e inoculando-se 4.000 ovos de H. glycines por vaso. Foram avaliados o número fêmeas nas raízes e o número de cistos/100 cm3 de solo. Os resultados mostraram que o número de fêmeas diminuiu à medida que se aumentaram as doses de calcário, até a dose de 3,039 t.ha-1, segundo uma resposta quadrática significativa. O número de cistos no solo reduziu linearmente à medida que foram aumentadas as doses de calcário.

    PALAVRAS-CHAVE: Nematóide de cisto; manejo do solo; calagem.

    The greenhouse study was carried out at Escola de Agronomia e Engenharia de Alimentos – Universidade Federal de Goiás, Brazil, to evaluate increasing levels of soil liming on Heterodera glycines population developing on soybean roots. The full dose of liming was determined in order to increase the base saturation up to 50%. The treatments were: control (no liming, half dose (0.675 t.ha-1, full dose (1.35 t.ha-1, double dose (2.7 t.ha-1, and triple dose (4.05 t.ha-1. The experimental design was completely randomized with five treatments and six replications. Each pot was planted with the cultivar FT-Cristalina and inoculated with 4

  7. Clinical analysis of senium patients with idiopathic membranous nephropathy associated with necrotizing and crescentic glomerulo-nephritis%老年特发性膜性肾病合并新月体坏死性肾小球肾炎的临床特点

    Institute of Scientific and Technical Information of China (English)

    金玲; 周广宇; 张文龙; 张博; 庄振起

    2014-01-01

    目的:探讨特发性膜性肾病( IMN)合并新月体坏死性肾小球肾炎的诊断思路及肾病理与预后的关系。方法5例IMN合并新月体坏死性肾小球肾炎经肾病理确诊,分析实验室指标和肾病理特点。结果5例患者4例为男性,1例为女性,平均年龄65岁,均伴肾外症状,血清抗中性粒细胞胞浆抗体( ANCA)阳性,呈重度蛋白尿、低白蛋白血症和不同程度的肾功能减退。肾病理示5例均有不同程度的新月体形成和坏死病变;电镜显示1例为Ⅰ~Ⅱ期膜性肾病,3例为Ⅱ~Ⅲ期膜性肾病,1例为Ⅲ期膜性肾病。经免疫抑制治疗1例病情好转,其余4例无缓解。结论肾病理对于确诊具有重要意义,预后可能与新月体形成的程度和IMN的电镜分期相关,免疫抑制治疗仅对轻症患者有效。%Objective To analyze the characteristics of laboratory examination and renal pathology in senium idiopathic membranous nephropathy ( IMN) patients associated with necrotizing and crescentic glomerulonephritis .To investigate the predictive features for diagno-sis, therapeutic methods and prognosis of two combined diseases .Methods Laboratory and pathological findings in 5 senium patients with IMN and necrotizing and crescentic glomerulonephritis were analyzed .Results Five cases of IMN with necrotizing and crescentic glomerulo-nephritis included 4 males and 1 female with average age of 65 years old.All the cases manifested nephrotic syndrome , renal deficiency and renal external symptoms such as fever , rash, arthralgia, sinusitis, hemoptysis and pulmonary nodules .Laboratory data showed positive AN-CA in the serum of 5 patients (four MPO-ANCA, one PR3-ANCA) and heavy proteinuria (mean 24 h urine protein 4.78 g/24 h), hy-poalbuminemia (mean serum albumin 23.34 g/L), different degrees of hematuria and renal deficiency (mean serum creatinine 263.06μmol/L) .Renal pathological evaluation revealed 5 cases of IMN

  8. Unmasking of complements using proteinase-K in formalin fixed paraffin embedded renal biopsies

    Directory of Open Access Journals (Sweden)

    R Nada

    2016-01-01

    Full Text Available Renal biopsy interpretation requires histopathology, direct immunofluorescence (DIF and electron microscopy. Formalin-fixed, paraffin-embedded tissue (FFPE sent for light microscopy can be used for DIF after antigen retrieval. However, complement staining has not been satisfactory. We standardized DIF using proteinase-K for antigen retrieval in FFPE renal biopsies. A pilot study was conducted on known cases of membranous glomerulonephritis (MGN, membranoproliferative type-1 (MPGN-1, immunoglobulin A nephropathy (IgAN, and anti-glomerular basement disease (anti-GBM. Immunofluorescence panel included fluorescein isothiocyanate (FITC conjugated IgG, IgA, IgM, complements (C3 and C1q, light chains (kappa, lambda and fibrinogen antibodies. After standardization of the technique, 75 renal biopsies and 43 autopsies cases were stained. Out of 43 autopsy cases, immune-complex mediated glomerulonephritis (GN was confirmed in 18 cases (Lupus nephritis-11, IgAN-6, MGN-1, complement-mediated dense deposit disease (DDD-1 and monoclonal diseases in 4 cases (amyloidosis-3, cast nephropathy-1. Immune-mediated injury was excluded in 17 cases (focal segmental glomerulosclerosis -3, crescentic GN-6 [pauci-immune-3, anti-GBM-3], thrombotic microangiopathy-5, atherosclerosis-3. Renal biopsies (n-75 where inadequate or no frozen sample was available; this technique classified 52 mesangiocapillary pattern as MPGN type-1-46, DDD-2 and (C3GN-4. Others were diagnosed as IgAN-3, lupus nephritis-2, MGN-4, diffuse proliferative glomerulonephritis (DPGN-1, Non-IC crescentic GN-1, monoclonal diseases-3. In nine cases, DIF on FFPE tissue could not help in making diagnosis. Proteinase-K enzymatic digestion of FFPE renal biopsies can unmask complements (both C3 and C1q in immune-complexes mediated and complement-mediated diseases. This method showed good results on autopsy tissues archived for as long as 15 years.

  9. Unmasking of complements using proteinase-K in formalin fixed paraffin embedded renal biopsies.

    Science.gov (United States)

    Nada, R; Kumar, A; Kumar, V G; Gupta, K L; Joshi, K

    2016-01-01

    Renal biopsy interpretation requires histopathology, direct immunofluorescence (DIF) and electron microscopy. Formalin-fixed, paraffin-embedded tissue (FFPE) sent for light microscopy can be used for DIF after antigen retrieval. However, complement staining has not been satisfactory. We standardized DIF using proteinase-K for antigen retrieval in FFPE renal biopsies. A pilot study was conducted on known cases of membranous glomerulonephritis (MGN), membranoproliferative type-1 (MPGN-1), immunoglobulin A nephropathy (IgAN), and anti-glomerular basement disease (anti-GBM). Immunofluorescence panel included fluorescein isothiocyanate (FITC) conjugated IgG, IgA, IgM, complements (C3 and C1q), light chains (kappa, lambda) and fibrinogen antibodies. After standardization of the technique, 75 renal biopsies and 43 autopsies cases were stained. Out of 43 autopsy cases, immune-complex mediated glomerulonephritis (GN) was confirmed in 18 cases (Lupus nephritis-11, IgAN-6, MGN-1), complement-mediated dense deposit disease (DDD-1) and monoclonal diseases in 4 cases (amyloidosis-3, cast nephropathy-1). Immune-mediated injury was excluded in 17 cases (focal segmental glomerulosclerosis -3, crescentic GN-6 [pauci-immune-3, anti-GBM-3], thrombotic microangiopathy-5, atherosclerosis-3). Renal biopsies (n-75) where inadequate or no frozen sample was available; this technique classified 52 mesangiocapillary pattern as MPGN type-1-46, DDD-2 and (C3GN-4). Others were diagnosed as IgAN-3, lupus nephritis-2, MGN-4, diffuse proliferative glomerulonephritis (DPGN)-1, Non-IC crescentic GN-1, monoclonal diseases-3. In nine cases, DIF on FFPE tissue could not help in making diagnosis. Proteinase-K enzymatic digestion of FFPE renal biopsies can unmask complements (both C3 and C1q) in immune-complexes mediated and complement-mediated diseases. This method showed good results on autopsy tissues archived for as long as 15 years.

  10. 77 FR 39413 - Safety Zone: Crescent City Fourth of July Fireworks Event, Crescent City, CA

    Science.gov (United States)

    2012-07-03

    ...: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed..., Governmental Actions and Interference With Constitutionally Protected Property Rights. 9. Civil Justice Reform... Atmospheric Administration (NOAA) Chart 18603. The safety zone will extend 560 feet around West Jetty...

  11. Efeito de doses crescentes de nitrogênio, fósforo e potássio sôbre a produção de raízes de mandioquinha-salsa Effect of increasing doses of nitrogen, phosphorus and potassium on the yield of Arracacia Xanthorriza

    Directory of Open Access Journals (Sweden)

    Jairo Ribeiro da Silva

    1966-01-01

    Full Text Available Numa experiência preliminar para estudar o efeito de doses crescentes dos três elementos essenciais sôbre a mandioquinha-salsa, sòmente o fósforo aumentou substancialmente a produção de raízes, tendo as doses de 80 e 160 kg/ha de P2O0 proporcionado respostas iguais, de +29%. Enquanto o efeito de 80 kg/ha de K(20 correspondeu a +14%, o da dose dupla foi nulo. Nas doses de 50 e 100 kg/ha, o nitrogênio deprimiu linearmente a produção.In a preliminary fertilizer trial with Arracacia xanthorrizaBank., conducted in the State of São Paulo, only phosphorus increased appreciably the root yield. The increase due to potassium was small. Nitrogen depressed the yield.

  12. 月牙肋抑振装置对柔性立管涡激振动抑振作用的试验研究%Experimental Investigation of Vortex-Induced Vibration Suppression on Flexible Riser Using Crescent-Shaped Device

    Institute of Scientific and Technical Information of China (English)

    刘晓春; 郭海燕; 张永波; 张文冬

    2011-01-01

    Vortex-induced vibration (VIV) would result in serious infection to the riser fatigue life.This paper presented a new designed crescent-shaped suppression device, and investigate the device performance on riser oscillation suppressing when VIV occurred, model experiment carried out in the wind-wavecurrent flume。 Various time history strain response in both in-line and cross-flow direction were obtained from the different arrangement on the riser surface.Based on the software DASP to process measurements data, strain amplitude and power spectrum were calculated.It was found that the crescent-shaped suppression device can evidently reduce oscillation amplitudes of the model riser, also can affect oscillation frequencies, different device arrangements performance differently on VIV Suppression.%海洋立管的涡激振动会对立管结构的疲劳寿命产生严重的影响.提出1种月牙肋抑振装置,通过在室内水槽中进行物理模型试验,研究该装置在涡激振动情况下对立管的抑振作用.测得该装置在立管表面不同布置方式时顺流向及横流向振动的应变时程曲线,使用DASP软件对所测数据进行分析处理,得到立管的振动幅值和功率谱.试验结果表明:这种月牙肋抑振装置可明显降低立管模型的振动幅值,且对振动频率有一定的影响,同时也表明不同的布置方式对立管的抑振效果也不相同.

  13. Possible consequences of increasing life expectancy in Brazil: the perspective of a European historical demographer Possíveis conseqüências da crescente longevidade no Brasil: perspectiva de um demógrafo

    Directory of Open Access Journals (Sweden)

    Arthur E. Imhof

    1987-10-01

    . Mais da metade das mulheres (52,8% da Alemanha sobreviveram até 80 anos de idade, de 1982/84, e quase metade dos homens (47,3% sobreviveram até 75 anos. A durabilidade da vida é hoje garantida de tal forma que teria sido inconcebível há poucas gerações. O tripé clássico de "peste, fome e guerra" ameaçava os nossos antepassados em todos os lugares e todo tempo. A transição radical de uma vida anteriormente incerta para a vida segura atual, resultado da repressão daquele tripé, levou a conseqüências imprevistas para o convívio em comunidade. Nossos antepassados eram obrigados a viver em sociedade, bem integrados na busca de sua sobrevivência física, e subordinar seus dejetos pessoais aos valores comuns; mas, agora, ao menos na sua maior parte, estas pressões desapareceram. O ego, com muito mais segurança, passou a ocupar lugar de destaque. Um número crescente de pessoas tem optado por uma vida solitária: o número de casamentos diminui a cada ano, o número de divórcios aumenta; em Berlim Ocidental, mais da metade (52,3% das "famílias" já se compõe de uma só pessoa. Durante os últimos 6 anos o número anual de nascimentos foi insuficiente para assegurar a reposição da população. O problema da Alemanha não é de explosão demográfica e, sim, de implosão. Os seres humanos já não parecem ser "animais sociais", como se supunha. Na verdade, a "peste, fome e guerra" os obrigavam a este comportamento. Quando estas condições ameaçadoras se modificaram e a vida se tornou mais segura, mesmo sem estarem integrados numa sociedade, os seres humanos vêm se tornando cada vez mais solitários. Não é a existência de população acima de 60 ou 65 anos que se constituiu um fator decisivo neste contexto, mas, sim, a percepção dos adultos de sua condição humana, desde que são eles que organizam suas vidas, que constroem comunidades e que com freqüência cada vez maior contraem uniões pessoais como um fim em si mesmo, sem laços chegados ou

  14. Acúmulo de N, K, Ca, Mg e S na matéria seca da parte aérea de mudas de cajueiro-anão-precoce submetidas a níveis crescentes de matéria orgânica

    Directory of Open Access Journals (Sweden)

    Lima Rosiane de Lourdes Silva de

    2003-01-01

    Full Text Available Com o objetivo de verificar os efeitos de níveis crescentes de matéria orgânica no acúmulo de macronutrientes de porta-enxertos de cajueiro-anão-precoce em 4 estádios de crescimento, foi conduzido experimento na área experimental do Departamento de Irrigação e Drenagem da Universidade Federal do Ceará, em Fortaleza, Ceará, no período de abril a junho de 1995. Utilizou-se como substrato mistura de solo e húmus de minhoca em proporções variadas. Para o plantio, utilizou-se semente de cajueiro-anão-precoce progênie CCP-76. Os tratamentos resultaram da aplicação de cinco níveis de matéria orgânica (0; 100; 200; 300 e 400 cm³/2,5kg solo e 4 épocas de avaliação (15; 30; 45 e 60 dias após a germinação. O delineamento experimental foi o inteiramente casualizado, em esquema de parcela subdividida, com quatro repetições e seis plantas por parcela. Amostras do material vegetal foram submetidas à digestão nítricoperclórica, para determinação de K, Ca, Mg e S, respectivamente, e sulfúrica, para determinar o N. A adição de níveis crescentes de matéria orgânica ao substrato apresentou efeito linear positivo, para o N e K, atingindo o máximo para a dose de 400 cm3. Em relação aos efeitos das épocas, verificou-se efeito linear negativo. Quanto ao Ca, Mg e S, por serem considerados de baixa mobilidade no floema, estes apresentaram tendências de concentração com o incremento de massa seca das mudas.

  15. Efeitos da inclusão de níveis crescentes de milheto (Pennisetum Glaucum (L. R. Brown grão na alimentação de suínos em crescimento e terminação Effect of feeding increasing levels of pearl millet (Pennisetum glaucum (L. R. Brown grain for growing and finishing pigs

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    Alexandre Orio Bastos

    2006-02-01

    Full Text Available Um experimento de desempenho foi conduzido com o objetivo de avaliar a viabilidade nutricional e econômica da utilização de rações com níveis crescentes de milheto na alimentação de suínos em crescimento e terminação. Foram utilizados 40 suínos (metade machos castrados e metade fêmeas, com peso inicial de 25,1±2,11 kg, distribuídos em quatro tratamentos, em delineamento de blocos casualizados, com cinco repetições e dois animais (um macho castrado e uma fêmea por unidade experimental. Os tratamentos consistiram de rações com níveis crescentes de milheto (0, 25, 50 e 75%. Não foram observados efeitos dos níveis de milheto sobre o consumo diário de ração (CDR, o ganho diário de peso (GDP e a conversão alimentar (CA na fase de crescimento. Entretanto, na fase de terminação, constatou-se efeito quadrático para o CDR e GDP, comprovando que a inclusão de 26,44% de milheto otimizou o GDP. A inclusão de até 75% de milheto em rações para suínos em crescimento e terminação atende aos requerimentos nutricionais dos animais nessas fases, sendo economicamente viável quando o valor de mercado corresponde a 70% do valor do milho.A performance trial was carried out to evaluate the nutritional and economical analyses of feeding increasing dietary levels of pearl millet for growing and finishing pigs. Forty crossbreed pigs averaging initial body weight of 25.1 ± 2.1 kg were assigned to four treatments as a randomized blocks design with five replicates and two pigs (one barrow and one gilt per experimental unit. The treatments contained the followign levels of pearl millet: 0, 25, 50 and 75%. No effects on daily feed intake (DFI, daily weight gain (DWG, and feed:gain ratio (FGR in the growing phase was detected. However, in the finishing phase, quadratic effect on DWG and DFI was observed, showing that the inclusion of 26.44% of pearl millet increased DWG. The inclusion of pearl millet up to 75% in the diets of growing and

  16. Staphylococcus Infection-Associated GN - Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort.

    Science.gov (United States)

    Satoskar, Anjali A; Suleiman, Sarah; Ayoub, Isabelle; Hemminger, Jessica; Parikh, Samir; Brodsky, Sergey V; Bott, Cherri; Calomeni, Edward; Nadasdy, Gyongyi M; Rovin, Brad; Hebert, Lee; Nadasdy, Tibor

    2017-01-06

    Staphylococcus infection-associated GN (SAGN) is a well recognized disease entity, particularly because of the frequent IgA-dominant glomerular immunoglobulin staining on kidney biopsy. Biopsy features can resemble two other disease entities - primary IgA nephropathy and Henoch-Schönlein purpura nephritis - posing a diagnostic pitfall. This is clinically relevant because of the crucial difference in the therapeutic approach. The diagnosis of SAGN is further complicated by the variability in the degree of glomerular IgA (and C3) staining, the extent of electron dense immune-type deposits, and positive ANCA serology in some patients. We performed a thorough histopathologic review of our single-center cohort of 78 culture-proven SAGN biopsies to assess the spectrum of IgA staining, prevalence of ANCA serology, prevalence of subepithelial "humps," and other histologic features to distinguish from primary IgA nephropathy. Among the 78 SAGN biopsies, IgA staining was trace in 25%, mild in 19%, moderate in 44%, and strong in 12% of the cases. C3 was frequently moderate-to-strong but was trace in 14% of the biopsies. Concomitantly trace IgA, IgG, and C3 (pauci-immune pattern) was seen in 13%. Crescents were present in 35% of the SAGN biopsies. Out of 41 patients tested for ANCA, nine (22%) were positive, including patients with endocarditis and other infections. Subepithelial humps were identified in only 31% of the SAGN biopsies. SAGN biopsies show marked variability in IgA immunofluorescence staining and low frequency of subepithelial humps compared with poststreptococcal GN. Occasional ANCA positivity is present in cases of SAGN, even in infections other than endocarditis. Therefore, biopsy diagnosis can be difficult particularly when clinical symptoms of infection are subtle. Both the pathologist and the nephrologist should be aware of these diagnostic pitfalls. Copyright © 2016 by the American Society of Nephrology.

  17. Renal histology in the elderly: indications and outcomes.

    LENUS (Irish Health Repository)

    2012-02-01

    Background: Renal disease is being increasingly diagnosed in the elderly. However, reports on biopsy-confirmed renal disease in this population are limited. The aim of this study was to give an overview of the most important indications, diagnoses and outcomes of renal biopsies in the elderly in our center. Methods: This was a retrospective review of all elderly renal biopsies over 5 years. Patients were eligible for inclusion if they were aged =65 years and had had a native kidney biopsy performed. The data recorded included age, sex, indications for biopsy, histological diagnoses and outcomes. Results: During this time, 1,372 native renal biopsies were performed. Of these, 236 (17%) were in patients aged =65 years; 150 male (64%) and 86 female (36%). The most common indications for biopsy were acute renal failure and nephrotic syndrome. Common diagnoses included pauci-immune crescentic glomerulonephritis, tubulointerstitial nephritis, membranous nephropathy, IgA nephropathy and chronic thrombotic microangiopathy. Long-term follow-up of 3 years was available for 102 patients; median serum creatinine at the time of biopsy was 427 micromol\\/L (interquartile range 204-702) and at 3 years post biopsy had fallen to 192 micromol\\/L (interquartile range 152-408). Conclusions: In our center, 17% of native kidney biopsies are performed in elderly patients aged =65 years. In our experience, this procedure was safe and had a 97% diagnostic rate. The available follow-up data of patients suggest that renal histology is not only of benefit in diagnosis but also of potential value in terms of prognosis and treatment.

  18. Renal histology in the elderly: indications and outcomes.

    LENUS (Irish Health Repository)

    Brown, Catherine M

    2011-06-28

    Background: Renal disease is being increasingly diagnosed in the elderly. However, reports on biopsy-confirmed renal disease in this population are limited. The aim of this study was to give an overview of the most important indications, diagnoses and outcomes of renal biopsies in the elderly in our center. Methods: This was a retrospective review of all elderly renal biopsies over 5 years. Patients were eligible for inclusion if they were aged =65 years and had had a native kidney biopsy performed. The data recorded included age, sex, indications for biopsy, histological diagnoses and outcomes. Results: During this time, 1,372 native renal biopsies were performed. Of these, 236 (17%) were in patients aged =65 years; 150 male (64%) and 86 female (36%). The most common indications for biopsy were acute renal failure and nephrotic syndrome. Common diagnoses included pauci-immune crescentic glomerulonephritis, tubulointerstitial nephritis, membranous nephropathy, IgA nephropathy and chronic thrombotic microangiopathy. Long-term follow-up of 3 years was available for 102 patients; median serum creatinine at the time of biopsy was 427 µmol\\/L (interquartile range 204-702) and at 3 years post biopsy had fallen to 192 µmol\\/L (interquartile range 152-408). Conclusions: In our center, 17% of native kidney biopsies are performed in elderly patients aged =65 years. In our experience, this procedure was safe and had a 97% diagnostic rate. The available follow-up data of patients suggest that renal histology is not only of benefit in diagnosis but also of potential value in terms of prognosis and treatment.

  19. Índice de translocação de nutrientes em mudas de cedro (Cedrela fissilis Vell. e de ipê-roxo (Tabebuia impetiginosa (Mart. Standl. submetidas a doses crescentes de cádmio, níquel e chumbo

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    Paiva Haroldo Nogueira de

    2002-01-01

    Full Text Available Com o objetivo de avaliar os efeitos da toxidez de Cd, Ni e Pb, mudas de cedro e de ipê-roxo foram cultivadas em solução nutritiva de Clark, em condições de casa de vegetação do Departamento de Ciência do Solo da Universidade Federal de Lavras, com doses crescentes de Cd (0, 22, 44, 88 e 132 mimol/l, de Ni (0, 42, 84, 169 e 252 mimol/l e de Pb (0, 48, 96, 192 e 288 mimol/l, adotando-se para tal um delineamento estatístico de blocos ao acaso, para os três ensaios. Ao final de 60 dias de exposição ao metal pesado, foram feitas avaliações do índice de translocação de macro e de micronutrientes da raiz para a parte aérea, tendo sido constatado que o aumento das doses de Cd, Ni e Pb exerceu efeitos sobre os índices de translocação de P, K, Ca, Mg, S, Cu, Fe, Mn e Zn, ora positivos, ora negativos, variando com a espécie, o metal pesado e o nutriente.

  20. The Optimal Gap between Small Gear's Addendum and Crescent Shaped Link of the Internal Involute Gear Pump%内啮合渐开线齿轮泵小齿轮齿顶与月牙板间的间隙优化

    Institute of Scientific and Technical Information of China (English)

    吴军强; 廖敏

    2011-01-01

    介绍内啮合渐开线齿轮泵的结构原理,从减小功率损失的角度出发,利用最优化设计理论、径向间隙泄漏理论和缝隙流量理论对内啮合渐开线齿轮泵小齿轮齿顶与月牙板间的间隙进行优化研究,推导出间隙优化模型,并求出最佳间隙解.%The structure and principle of internal involute gear pump were introduced. In purpose of reducing the power loss, the optimal gap between small gear's addendum and crescent shaped link of the internal involute gear pump was researched, by using the optimization theory and method, the radial gap leakage theory and the gap flow theory. The mathematical model of the optimal gap was concluded, and the optimal gap was calculated.

  1. Efeito da adição de níveis crescentes de polpa cítrica sobre a qualidade fermentativa e o valor nutritivo da silagem de capim-elefante Effect of increasing levels of citrus pulp on the fermentation quality and nutritive value of elephantgrass silage

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Mazza Rodrigues

    2005-08-01

    Full Text Available Foram estudados os efeitos da adição de polpa cítrica sobre a qualidade fermentativa e o valor nutritivo da silagem de capim-elefante. O capim-elefante, apresentando 90 dias de crescimento, foi ensilado com níveis crescentes de polpa cítrica peletizada: 0; 2,5; 5; 7,5; 10; 12,5 e 15%, com base na matéria fresca. As silagens foram produzidas em 28 silos experimentais (quatro repetições/tratamento, confeccionados a partir de baldes plásticos com válvulas do tipo Bunsen. A abertura dos silos ocorreu 106 dias após a ensilagem, quando foram determinados os teores dos ácidos orgânicos e a composição químico-bromatológica das silagens. Foi observado efeito linear crescente da adição de polpa cítrica sobre os teores de matéria seca, o mesmo ocorrendo para carboidratos solúveis e digestibilidade in vitro da matéria seca, mas com redução nos teores de nitrogênio amoniacal e fibra em detergente neutro. Para os teores de ácidos orgânicos (acético, lático e butírico e etanol, observou-se comportamento quadrático para as curvas obtidas, com pontos de máxima para o ácido lático igual a 5,8% e de mínima para os ácidos acético, butírico e o etanol, iguais a 7,8; 7,2; e -3,7% de polpa, respectivamente. Não foram observados efeitos sobre os valores de pH, assim como para os teores de lignina e de ácido propiônico. Inclusões de 4,7 a 7,6% de polpa cítrica peletizada, com base na matéria fresca, são suficientes para melhorar a qualidade e o valor nutritivo da silagem de capim-elefante.The effects of increasing levels of citrus pulp on fermentation pattern and nutritive value of elephantgrass silage was evaluated. Elephantgrass harvested at 90 days was ensiled with increasing levels of dried citrus pulp: 0, 2.5, 5, 7.5, 10, 12.5 and 15% (fresh matter basis. Silages were produced in 28 plastic experimental silos (4 replicates/treatment bearing Bunsen valves. Silos were opened 106 days after ensiling, when samples were

  2. Intake, apparent digestibility and ruminal characteristics of the lambs fed with increasing levels of concentrate in tropical environment in the Valley of Guaporé - MTConsumo, digestibilidade dos nutrientes e características ruminais de cordeiros alimentados com níveis crescentes de concentrado em ambiente tropical no Vale do Alto Guaporé - MT

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    Luiz Juliano Valério Geron

    2013-10-01

    Full Text Available The objective was to evaluate the use of concentrate in the diet of lambs on intake and total digestibility coefficient (DC of nutrients, ruminal characteristics, rectal and body temperature. It was used four lambs without breed defined (SRD, entire, with average body weight (BW of 19.3 ± 2.07 kg using a Latin square design, 4 x 4. The animals were housed in metabolism cages and were fed twice a day with diet consisting of corn silage and concentrate at a ratio of 20, 40, 60 and 80% dry matter in the diet, composite of corn grains and soybean meal. Leftovers were measured daily and the feces were collected through bags. Data from variables studied were submitted to ANOVA and regression analysis at 5% probability. The increasing levels of concentrate in lamb diets affected (P0.05 of concentrate levels on digestibility coefficient of DM, OM, EE, NDF, ADF, NFC and TCH. However, the digestibility coefficient of CP showed a quadratic effect (P0.05 by dietary concentrate. It can be concluded that 38% of concentrate in diets of lambs favors the maximum dry matter intake, organic matter and crude protein. The digestibility coefficient of the nutrients, except for protein, are not altered with the addition up to 80% concentrate in diet for lambs, as well as, this does not affect the pH and ammonia nitrogen concentration of ruminal fluid, rectal and body temperature. Objetivou-se avaliar níveis crescentes de concentrado na dieta de cordeiros sobre o consumo e coeficiente de digestibilidade total (CD dos nutrientes, características ruminais, temperatura corporal e retal. Foram utilizados quatro cordeiros sem raça definida (SRD, não castrados, com peso corporal (PC médio de 19,3 Kg ± 2,07 por meio de um delineamento em quadrado latino 4 x 4. Os animais foram alojados em gaiolas de metabolismo, os quais foram alimentados duas vezes ao dia, com dieta composta por silagem de milho e concentrado, na proporção de 20, 40, 60 e 80% na matéria seca da

  3. Efeitos de doses crescentes de calcário em solo Latossolo Amarelo na produção de mudas de pau-de-balsa (Ochroma lagopus sw., bombacaceae Effects of the rising heat in Yellow Oxisoil in the production of silent wood rafts (Ochroma lagopus sw., bombacaceae

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    Carlos Alberto Franco Tucci

    2010-09-01

    Full Text Available A produção de mudas de qualidade com adequado teor nutricional é fundamental para o desenvolvimento da planta e para a formação do sistema radicular, a qual apresentará melhor capacidade de adaptação ao novo local após o plantio. O objetivo deste trabalho foi avaliar o efeito de níveis crescentes de calcário na produção de mudas de pau-de-balsa. Os tratamentos foram constituídos de doses crescentes de corretivo e equivaleram a 0,0; 0,25; 0,5; 0,75; 1,0; 1,5 e 2,0 t ha-1 de calcário e o delineamento experimental utilizado foi o de blocos casualizados com cinco repetições. As características avaliadas foram: altura da planta; diâmetro do colo, matéria seca da parte aérea, matéria seca total, relação raiz/parte aérea, teores totais de macronutrientes nas plantas (N, P, K, Ca, Mg e S. Os resultados demonstraram que a prática de calagem como fator de correção do solo usado no substrato favoreceu todas as características de crescimento avaliadas na produção de mudas de pau-de-balsa. A correção do solo influenciou positivamente a absorção de Ca, Mg e S, por outro lado, não apresentou efeitos estatisticamente significativos para a absorção de N, P e K.The production of quality rafts with appropriate nutritional tenor is fundamental for plant development and for forming of root systems, which present best ability to adapt to new locations after plantation. The goal of this work was to evaluate the effect of rising heat levels in the production of silent wood rafts. The treatment was constituted by rising doses of correction and was equal to 0.0; 0.25; 0.5; 0.75; 1.0; 1.5, and 2.0 t ha-1 of lime and the experimental detail used was of blocks, repeating five times. The characteristics evaluated were: plant height; diameter, dry material of the aerial part, root relation/aerial part, content of macronutrients in the plants (N, P, K, Ca, Mg and S. The results demonstrate that the practice of liming as a soil correction

  4. From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation

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    Liang Liu

    2014-10-01

    Full Text Available Vaccinia virus (VACV has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outstanding questions, in particular, the origin and biogenesis of the virion membrane, the transformation from immature virion (IV to mature virus (MV, and the role of several novel genes, which were previously uncharacterized, but have now been shown to be essential for VACV virion formation. This new knowledge will undoubtedly contribute to the rational design of safe, immunogenic vaccine candidates, or effective antivirals in the future. This review endeavors to provide an update on our current knowledge of the VACV maturation processes with a specific focus on the initiation of VACV replication through to the formation of mature virions.

  5. Risco crescente de melanoma de pele no Brasil

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    Guinar Azevedo e Silva Mendonça

    1992-08-01

    Full Text Available A ocorrência de melonoma maligno de pele no Brasil é analisada a partir dos dados de mortalidade disponíveis no Ministério da Saúde e dos dados de incidência dos seis Registros de Câncer de Base Populacional, localizados em seis capitais brasileiras. Os coeficientes de incidência nessas capitais situam-se em padrões intermediários se comparadas às cifras mundiais. Para o Município de Porto Alegre, uma das capitais estudas, que apresentou os maiores coeficientes de incidência, é feita comparação entre os dados relativos ao período 1979-1982 e 1987, constatando-se que houve aumento relativo de 38% entre homens e de 11% entre mulheres. Concluiu-se pela necessidade de se conduzir estudos no Brasil entre comunidades de indivíduos de pele clara, os quais apresentam risco potencializado para o desenvolvimento de melanoma, para que sejam definidas medidas específicas e eficazes de controle.

  6. Mac Bride Community Nursing Unit, St. Mary's Crescent, Westport, Mayo.

    LENUS (Irish Health Repository)

    Ramasubbu, B

    2017-02-01

    Scaphoid fractures are the most common carpal bone fracture. Up to 40% of scaphoid fractures can be missed at initial presentation and investigation. Follow-up plain film radiograph has overall poor sensitivity and reliability. MRI has been shown to have an almost 100% sensitivity and specificity and so is the gold standard in scaphoid fracture diagnosis. Additionally, early specialist involvement is recommended. We proposed that following a designated pathway, there would be no significant increase in MRI requests. Following implementation of a pathway for the management of suspected scaphoid fractures in St James’s Hospital in 2012 re-auditing demonstrated that management changed to either MRI directly after initial x-ray (16\\/145, 11%), MRI after second x-ray (9\\/28, 32%) or orthopaedic follow-up (19\\/28, 68%). The number of MRIs requested was consistent with our predictors of demand. Thus, our new protocol maximises diagnostics, cost effectiveness and quality of patient care.

  7. Rendimento de coentro cultivado com doses crescentes de N

    Directory of Open Access Journals (Sweden)

    Oliveira Ademar P. de

    2003-01-01

    Full Text Available Avaliou-se o efeito de diferentes doses de N sobre o rendimento do coentro. O experimento foi conduzido no Centro de Ciências Agrárias da UFPB, em Areia, entre junho e agosto/2001. O delineamento experimental foi de blocos casualizados, com cinco tratamentos (0,0; 20; 40; 60 e 80 kg ha-1 de N, em quatro repetições. Utilizou-se a cultivar Verdão num espaçamento de 20 cm x 5,0 cm, em parcelas de 2,0 m². As avaliações foram feitas aos 50 dias após a semeadura. Os resultados indicaram que a altura das plantas aumentou linearmente com a elevação das doses de N. O emprego da dose máxima de N (80 kg ha-1, proporcionou um incremento de 17,4% na altura das plantas em relação à testemunha. O rendimento de massa verde aumentou linearmente em função das doses de N, alcançando valor máximo de 5,4 kg m-2na dose de 80 kg ha-1, que correspondeu a um incremento de 62% em relação à testemunha (3,3 kg m-2.

  8. Mac Bride Community Nursing Unit, St. Mary's Crescent, Westport, Mayo.

    LENUS (Irish Health Repository)

    Holland, Deirdre M

    2015-04-01

    Medication reconciliation is a basic principle of good medicines management. With the establishment of the National Acute Medicines Programme in Ireland, medication reconciliation has been mandated for all patients at all transitions of care. The clinical pharmacist is widely credited as the healthcare professional that plays the most critical role in the provision of medication reconciliation services.

  9. Regimes de financiamento, risco crescente do endividamento e fragilidade financeira

    Directory of Open Access Journals (Sweden)

    Gilberto Tadeu Lima

    2005-06-01

    Full Text Available Elabora-se um modelo macroeconômico de curto prazo na tradição pós-keynesiana, no qual a oferta de crédito é endógena e o grau de endividamento das firmas é explicitamente modelado. Relacionam-se as condições de vigência dos regimes minskyanos de financiamento - hedge, especulativo ou Ponzi - não somente ao grau de endividamento e à taxa de juros, mas, inclusive, aos parâmetros da função investimento desejado da firmas e à propensão a poupar dos capitalistas produtivos e financeiros.It is developed a short-run macromodel in the post-keynesian tradition, in which credit supply is endogenous and firms' debt position is explicitly modeled. The conditions under which each one of the minskyan financing regimes will prevail are related not only to the degree of indebtedness and the level of interest rate, but also to the parameters of firms' desired investment function and the saving propensity of productive and financial capitalists.

  10. Digestibilidade e tempo de trânsito gastrintestinal de dietas contendo níveis crescentes de fibra bruta para pacu - doi: 10.4025/actascianimsci.v32i2.8625 Digestibility and gastrointestinal transit time of diets with increasing dietary fiber levels to pacu - doi: 10.4025/actascianimsci.v32i2.8625

    Directory of Open Access Journals (Sweden)

    Thiago Matias Torres Nascimento

    2010-07-01

    Full Text Available O objetivo deste trabalho foi avaliar a digestibilidade e o tempo de trânsito gastrintestinal (TTGI de dietas contendo níveis crescentes de fibra bruta (FB para pacus. Para avaliar a digestibilidade foram utilizados 288 pacus, em delineamento inteiramente casualizado, alimentados em aquários e transferidos para coletores do tipo Guelf Modificado, utilizando-se o método de coleta parcial de fezes. As rações foram marcadas com 1% de óxido de crômio para a determinação da digestibilidade das dietas. No ensaio de TTGI, 288 pacus foram distribuídos em 24 aquários em delineamento inteiramente casualizado e alimentados com rações contendo 1% óxido de titânio ou crômio, que apresentam cores diferentes, verde ou branca, respectivamente. Por meio de massagem abdominal foi averiguada periodicamente a cor das fezes, e o TTGI foi estabelecido quando as fezes de todos os peixes apresentaram cor verde. Os coeficientes de digestibilidade aparente das dietas e o TTGI foram reduzidos com aumento do nível de FB nas dietas. Conclui-se que em dietas para pacus pode-se empregar até 9% de FB sem efeito negativo na digestibilidade da energia, proteína, matéria seca e estrato etéreo e sem alterar o TTGI.This work aimed to evaluate the effect of increasing dietary fiber levels on the digestibility and gastrointestinal transit time (GTT for pacu. The digestibility trial used 288 pacu in a completely randomized design, fed in aquaria and transferred to a modified Guelf-type feces collector, using the partial sampling method. The inert marker on the diets was chromic oxide (1% to establish the diet digestibility. In the GTT assay, 288 pacu were distributed in 24 aquaria in a completely randomized design. Fish were fed with two colored diets – green and white – and feces color was determined after abdominal pressure. The white and green diets used 1% of titanium and chromic oxides, respectively. Total GTT was determined when all fish showed green

  11. Produtividade do Capim-Cameroon estabelecida em duas classes de solos e submetido a doses crescentes de nitrogênio no norte tocantinense = Production of Cameroon grass in two soil classes with increasing nitrogen levels in the north of Tocantins State, Brazil

    Directory of Open Access Journals (Sweden)

    Rossini Sôffa da Cruz

    2010-10-01

    Full Text Available Este estudo foi desenvolvido com o objetivo de avaliar o capim-elefante cv. Cameroon em função de doses de N em diferentes solos. Foi utilizado o delineamento experimental inteiramente casualizado em fatorial 5 x 2, sendo cinco doses de nitrogênio (0, 30, 60, 90, e 150 kg de N ha-1, testadas em duas classes de solo (Argissolo Vermelhoeutroférrico típico e Neossolo Quartzarênico órtico típico, com quatro repetições. Os parâmetros avaliados foram: altura da planta, perfilhos, massa por perfilho, relação folha: colmo, matéria seca e pH do solo. Houve resposta positiva para ambos os solos, sendo amelhor resposta para o Argissolo. A massa dos perfilhos em gramas mostra efeito linear em função dos níveis de N e no Neossolo não houve diferença entre os tratamentos. O aumento da massa individual de perfilhos teve maior efeito na massa seca total. A adubaçãoN promoveu acidificação linear decrescente maior no Argissolo. O desenvolvimento do capim, em função dos níveis crescentes de N apresentou resposta positiva para ambos os solos, sendo melhor para o Argissolo em comparação ao Neossolo.The development of elephant grass at increasing nitrogen rates in two soil classes was evaluated. A totally randomized 5 x 2 design, with five nitrogen levels (0, 30, 60, 90, and 150 kg N ha-1, in two classes of soil (Oxisol and Entisol, with four repetitions, was employed. Evaluated parameters consisted of plant height, tillers, mass per tiller, leaf:stem ratio, dry matter and pH of soil. Althoughthe production of Pennisetum purpureum was positive for both types of soil, best response occurred in Oxisol. Whereas mass (in grams of the tillers had a linear effect according to nitrogen rates, there was no difference between treatments in Entisol. Increase of tillers’mass had the highest effect on total dry mass. Nitrogen fertilization promoted highest decreasing acidification in Ultisol. Due to increasing levels of nitrogen the development of

  12. Modelos matemáticos para o estudo do fluxo biológico do fósforo em suínos alimentados com dietas suplementadas com níveis crescentes de fitase Mathematical models for the study of the biological flow of phosphorus in pigs fed with diets containing increasing levels of phytase

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    J.A. Moreira

    2009-04-01

    Full Text Available A pesquisa foi realizada para avaliar o fluxo biológico do fósforo entre os compartimentos, fisiológicos ou anatômicos, de suínos mantidos em dietas que continham níveis crescentes de fitase, usando o P-32 como traçador. O delineamento experimental foi inteiramente ao acaso, sendo os tratamentos constituídos por níveis de enzima fitase, 253, 759, 1265 e 1748 UF/kg, nas dietas. As variáveis avaliadas foram: ingestão, excreção, atividades específicas e fluxo de P nos compartimentos (trato digestivo, corrente sanguínea, tecidos moles e ossos. A enzima fitase não interferiu nas excreções fecais e urinárias, nas atividades específicas, na incorporação e na reabsorção de P nos ossos e nos tecidos moles e no fluxo bidirecional do trato digestivo e na corrente sanguínea, mas afetou linearmente a absorção e a retenção nos ossos. As respostas mais evidentes dos efeitos da adição da fitase são observadas nos níveis mais baixos.The biological flow of P was evaluated among the physiologic or the anatomical compartments of pigs fed diets with increasing phytase levels, using P-32 as tracer. The experimental design was completely randomized. Treatments consisted of phytase levels in diets (253, 759, 1265, and 1748UF/kg. The evaluated variables were: feed intake, excretion, specific activities and flow of P in the compartments (gut, blood, bone, and soft tissus. Phytase level did not interfere with fecal and urinary excretion, specific activities, incorporation and resorption of bone, and soft tissue P and in the bidirectional flow of gut and blood, but linearly affected P absorption and bone P retention. The best response was observed with the lowest phytase levels.

  13. Desempenho produtivo, composição corporal e parâmetros fisiológicos de pacu alimentado com níveis crescentes de fibra Productive performance, body composition and physiological parameters of pacu fed increasing levels of fiber

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    Laurindo André Rodrigues

    2010-08-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de teores de fibra bruta na dieta sobre o desempenho produtivo, composição centesimal da carcaça e parâmetros fisiológicos de juvenis de pacu. O experimento teve duração de 84 dias, e foram utilizados 360 juvenis de pacu, com peso médio de 23,97±0,59 g, distribuídos aleatóriamente em 30 tanques com 180 L de água, em delineamento inteiramente casualizado, com seis tratamentos (5, 7, 9, 11, 13 e 15% de fibra bruta e cinco repetições. Dietas com altos teores de fibra (11, 13 e 15% resultaram em piores taxas de ganho de peso, conversão alimentar e crescimento específico, além de menor eficiência proteica e consumo de ração. A composição da carcaça dos animais foi alterada pelo aumento do teor de fibra das dietas. Os teores de proteína e cinza tiveram aumento com o incremento nos teores de fibra. O metabolismo foi alterado com o emprego de teores crescentes de fibra, o que resultou em pequena elevação do colesterol plasmático. Teores de fibra bruta de até 9% não tiveram efeitos negativos no metabolismo; entretanto, teores acima de 11% reduziram o crescimento dos peixes.The objective of this work was to evaluate the effects of dietary crude fiber contents on productive performance, carcass composition and physiological parameters of pacu juveniles. The experiment was carried out during 84 days, 360 pacu juveniles were used with mean weight 23.97±0.59 g, stocked in 30 tanks with 180 L of water, in a completely randomized design, with six treatments (5, 7, 9, 11, 13 and 15% crude fiber and five replicates. Diets with high fiber contents (11, 13 and 15% resulted in worse rates of weight gain, feed conversion, and specific growth, besides lower protein efficiency ratio and feed consumption. Carcass composition changed by increasing the contents of dietary fiber. Body contents of protein and ash increased along with the fiber levels. The metabolism changed with the use of

  14. Influência de doses crescentes de chumbo sobre o teor e o conteúdo de nutrientes e Pb em mudas de ipê-roxo (Tabebuia impetiginosa (Mart. Standl. Influence of increasing lead levels on nutrient and Pb content and accumulation in ipê-roxo (Tabebuia impetiginosa (Mart. Standl. seedlings

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    Haroldo Nogueira de Paiva

    2003-04-01

    Full Text Available O efeito da aplicação de chumbo sobre o teor e o conteúdo de nutrientes e Pb na raiz, no caule e nas folhas de mudas de ipê-roxo (Tabebuia impetiginosa (Mart. Standl. foi estudado em um experimento realizado em casa de vegetação do Departamento de Ciência do Solo da Universidade Federal de Lavras. As mudas foram cultivadas em solução nutritiva de Clark e submetidas a doses crescentes de Pb: 0, 48, 96, 192 e 288 mimol/l. O experimento foi conduzido em delineamento estatístico de blocos ao acaso, e após 60 dias de exposição ao metal pesado foram feitas avaliações do teor e do conteúdo de macro, micronutrientes e chumbo na matéria seca de raiz, caule e folha. Os resultados mostraram que a aplicação de chumbo aumentou o teor de P e praticamente não afetou os teores de S, Ca e Mg nas mudas. De modo geral os teores de Cu, Fe e Mn sofreram redução, o teor de Zn não foi afetado, enquanto o conteúdo de macro e de micronutrientes sofreu redução. O teor de Pb na matéria seca de raiz, caule e folha aumentou com as doses aplicadas, principalmente na raiz, e se mostrou pouco móvel nas plantas analisadas.The effect of lead application on nutrient and Pb content and accumulation in ipê-roxo (Tabebuia impetiginosa (Mart. Standl. seedlings was studied in an experiment conducted under greenhouse conditions at the Soil Science Department of the Federal University of Lavras. The seedlings were cultivated in Clark nutrient solution and submitted to increasing Pb levels: 0, 48, 96, 192 and 288 mumol/l. The experiment was arranged in a randomized block design and after 60 days of exposure to the heavy metals, evaluations of macro and micronutrient and lead content and accumulation in the root, stem and leaf dry matter were made. The results showed that lead application increased P content and practically did not affect S, Ca and Mg contents. Cu, Fe and Mn contents, in general, presented a reduction; Zn content was not affected while macro

  15. Detection of immune deposits in skin lesions of patients with Wegener's granulomatosis

    NARCIS (Netherlands)

    Brons, RH; de Jong, MCJM; de Boer, NK; Stegeman, CA; Kallenberg, CGM; Tervaert, JWC

    2001-01-01

    Background-Wegener's granulomatosis (WG) is considered a pauci-immune systemic vasculitis based on the absence of immune deposits in renal biopsies of patients with active disease. In animal models of antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis, immune deposits along the

  16. Produção e composição químico-bromatológica da aveia preta fertilizada com doses crescentes de dejeto líquido suíno Production and chemical composition of the common black oats fertilized with growing doses of liquid swine manure

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    Daniela Mondardo

    2011-06-01

    Full Text Available O trabalho teve como objetivo avaliar o efeito da aplicação de doses crescentes de dejeto líquido suíno sobre a produção e composição químico-bromatológica da parte aérea da aveia preta. O experimento foi conduzido em sistema de plantio direto sob o delineamento em blocos casualizados com quatro repetições e os tratamentos constituídos pela aplicação de 0; 10; 20; 30; 40 e 50 m³ ha-1 de dejeto líquido suíno. Foram determinados a produção de MS da parte aérea, a relação folha:colmo e os teores de proteína bruta (PB, fibra em detergente ácido (FDA, fibra em detergente neutro (FDN, matéria mineral (MM, matéria orgânica (MO, nitrogênio (N, fósforo (P, potássio (K, cálcio (Ca, magnésio (Mg, cobre (Cu, zinco (Zn, manganês (Mn e ferro (Fe. A aplicação de dejeto líquido suíno não promoveu efeitos significativos sobre a produção de MS e teores de FDN, MM e MO, mas promoveu aumento linear da relação folha:colmo e do teor de PB e redução linear no teor de FDA. Quanto aos minerais, as doses de dejeto líquido suíno promoveram aumento linear nos teores de N, P, K, Ca e Zn, sem efeitos sobre os demais minerais estudados. A utilização de dejeto líquido suíno na fertilização da cultura da aveia até a dose de 50 m³ ha-1 não aumenta a produção de forragem mas eleva o valor nutricional.The work has as objective evaluate the effect of application of increasing doses of pig slurry under yield and chemical composition of black oat shoot. The experiment was carried out in no-tillage system under experimental design of randomized blocks with four replications and the treatments composed by application of 0; 10; 20; 30; 40; 50 m³ ha-1 of pig slurry. Were determined the yield of total dry mass, the leaf-stem ratio and content of crude protein (CP, acid detergent fiber (ADF, neutral detergent fiber (NDF, mineral matter (MM, organic matter (OM, nitrogen (N, phosphorus (P, potassium (K, calcium (Ca, magnesium (Mg

  17. Desempenho produtivo e parâmetros de carcaça de cordeiros mantidos em pastos irrigados e suplementados com doses crescentes de concentrado = Productive performance and carcass traits of lambs grazing on irrigated pastures and receiving increasing concentrate levels

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    Rafael Araújo Souza

    2010-07-01

    Full Text Available O presente estudo teve como objetivo avaliar o desempenho produtivo e os parâmetros de carcaça de ovinos terminados em pastos irrigados de Tifton 85 que receberam doses crescentes de concentrado. Foram comparadas quatro doses de concentrado (0; 0,66; 1,33 e 2,00% da matéria seca - MS em relação ao peso corporal dos animais. O período experimental foi de 84 dias, divididos em quatro sub-períodos de 21 dias. Foram utilizados 24 animais testadores, machos, castrados, da raça Santa Inês com peso corporal médio inicial de 20,5 ± 3,8 kg. O delineamento utilizado foi o inteiramente casualizado com seis repetições. O aumento no teor de concentrado proporcionou maior peso corporal final, ganho médio diário, ganho de peso total, escore de gordura pélvico-renal, consumo de matéria seca total, comprimento externo da carcaça, largura da garupa, largura do tórax, profundidade do tórax, perímetro da garupa e perímetro do pernil, além de menor consumo de forragem e contagem de ovos por grama de fezes. Entretanto, o rendimento de carcaça quente não foi influenciado pelas doses de suplemento concentrado. O aumento nas doses de concentrado para ovinos mantidos em pastagens de Tifton 85 melhorou o desempenho produtivo e o peso da carcaça.The objective of this present study was to evaluate the productive performance and carcass traits of lambs finished on Tifton 85 irrigated pastures and receiving increasing levels of concentrate. Four levels of concentrate were compared on a dry matter basis (0, 0.66, 1.33 and 2.00% in relation to the body weight of animals. The experimental period was 84 days, divided into four sub-periods of 21 days. Twentyfour Santa Ines male sheep, castrated, weighting 20.5 kg, were used as testers. The experimental design was completely randomized with six replications. The increase in concentrate levelspromoted higher final body weight, average daily gain, total weight gain, total dry matter intake, pelvic-renal fat

  18. Peso e rendimento dos componentes do peso vivo de cordeiros terminados em confinamento com dietas contendo proporções crescentes de resíduo úmido de cervejaria Weight and yield of liveweight components of feedlot finish lambs fed diets with increasing proportions of wet brewery residue

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    M.A. Brochier

    2008-10-01

    Full Text Available Avaliou-se o efeito de dietas contendo proporções crescentes de resíduo úmido de cervejaria sobre o peso e proporção dos componentes do peso vivo de cordeiros terminados em confinamento. Foram utilizados 25 cordeiros, machos, não-castrados, da raça Texel, distribuídos aleatoriamente em cinco tratamentos compostos por proporções de 0%, 25%, 50%, 75% e 100% de substituição do alimento concentrado por resíduo úmido de cervejaria. Utilizou-se dieta composta de feno de Tifton-85 e mistura concentrada em uma relação volumoso:concentrado de 40:60, na matéria seca. O alimento concentrado foi constituído por milho desintegrado, farelo de soja, mistura mineral e resíduo úmido de cervejaria, sendo que suas proporções variaram de acordo com os tratamentos. Houve redução linear dos pesos de sangue, patas, cabeça, fígado, pulmão e baço, e da proporção de fígado, à medida que se elevou a proporção do resíduo úmido de cervejaria nas dietas. A proporção, em relação ao peso vivo, de rúmen/retículo e do trato gastrintestinal, com conteúdo, e do conteúdo gastrintestinal aumentou linearmente, enquanto os pesos de rúmen/retículo, abomaso, intestino delgado e do trato gastrintestinal, sem conteúdo, diminuíram linearmente com o aumento da proporção do resíduo nas dietas. A proporção de rúmen/retículo, sem conteúdo, foi influenciada de forma quadrática.The effect of diets with increasing proportions of wet brewery residue on the weight and proportion of live weight components of feedlot finished lambs was evaluated. Twenty-five non-castrated Texel male lambs were randomly allotted into five groups, consisting in the replacement of the concentrate by wet brewery residue; at the proportions of 0%, 25%, 50%, 75%, and 100%. Diet composition was Tifton-85 hay and concentrate mixture, in a relation roughage:concentrate of 40:60, based on dry matter (DM. The concentrate was composed of ground corn, soybean meal, mineral

  19. Adições crescentes de ácido fítico à dieta não interferiram na digestibilidade da caseína e no ganho de peso em ratos Increasing quantities of phytic acid in the diet did not affect casein digestibility and weight gain in rats

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    Admar Costa de Oliveira

    2003-06-01

    Full Text Available O crescente consumo de alimentos de origem vegetal, sejam como fontes protéicas com baixo teor de gordura ou como fontes de fibras, tem acrescido à dieta humana o ácido fítico. Devido à sua carga altamente negativa, o ácido fítico tem sido visto como componente de ação antinutricional capaz de quelar minerais bivalentes, proteínas e amido, podendo comprometer a biodisponibilidade destes nutrientes. No presente estudo investigou-se a influência da adição de ácido fítico à dieta de caseína, em concentrações iguais ou até oito vezes superiores àquelas encontradas no feijão-comum Phaseolus vulgaris, cultivar IAC-Carioca (14,7mg de ácido fítico/g feijão cru, durante período experimental de dez dias, sobre os índices nutricionais Ganho de Peso, Quociente de Eficiência da Dieta, Quociente de Eficiência Protéica Líquida, Digestibilidade Aparente e Digestibilidade Verdadeira. Trinta e seis ratos machos SPF da linhagem Wistar, recém-desmamados, divididos em grupos experimentais com seis ratos cada, foram alimentados com dieta purificada AIN-93G isenta de ácido fítico (Controle e dietas teste AIN-93G acrescidas de 218, 436, 872 e 1744mg de ácido fítico/kg de dieta (Tratamentos. Os ganhos de peso (g e os índices de qualidade dietética e protéica não apresentaram diferença estatística (p>0,05, e os valores médios entre os grupos foram: Ganho de Peso: 59,5 ± 5,0g; Quociente de Eficiência da Dieta: 0,39 ± 0,01; Quociente de Eficiência Protéica Líquida: 3,64 ± 0,12; Digestibilidade Aparente: 92,7 ± 1,1% e Digestibilidade Verdadeira: 94,4 ± 0,9%. Os resultados demonstraram que nas condições experimentais utilizadas, o ácido fítico não foi capaz de alterar o valor nutritivo da caseína.The recent increasing consumption of vegetal origin foods, in order to obtain protein or fiber sources with low fat, has led to the presence of various amounts of phytic acid in the diet. The phytic acid has a strong negative

  20. Efeito de níveis crescentes de uréia na dieta de vacas em lactação sobre a produção e a composição físico-química do leite Effect of increasing dietary urea levels on milk yield and composition of lactating cows

    Directory of Open Access Journals (Sweden)

    Adriana Augusto Aquino

    2007-08-01

    Full Text Available Avaliou-se o efeito de níveis crescentes de uréia na dieta de vacas em lactação sobre a produção e composição físico-química do leite. Foram utilizadas nove vacas holandesas em lactação, distribuídas em três quadrados latinos 3 x 3, com três tratamentos e três períodos de coleta. O experimento teve duração de 63 dias, divididos em três períodos de 21 dias. Os tratamentos consistiram de uma dieta controle, formulada para suprir 100% das exigências de PB, proteína degradável no rúmen (PDR e proteína não-degradável no rúmen (PNDR, composta de farelo de soja como principal fonte protéica e cana-de-açúcar como volumoso, e de duas outras dietas, semelhantes à dieta controle, mas com 0,75 ou 1,5% de uréia em substituição ao farelo de soja. As dietas foram isoenergéticas (1,53 Mcal/kg de energia líquida de lactação e isoprotéicas (16% de PB. Quando os resultados foram analisados por regressão polinomial simples, não houve efeitos das dietas sobre o consumo de MS, as produções de leite e de leite corrigida para 3,5% de gordura, os teores de proteína e gordura e a contagem de células somáticas do leite. Os níveis de substituição do farelo de soja por uréia não influenciaram o pH, a crioscopia ou a densidade do leite. No entanto, verificou-se efeito linear decrescente dos níveis de uréia na dieta sobre a acidez do leite. Os teores de proteína, gordura, lactose, uréia, extrato seco total e extrato seco desengordurado não foram afetados pelas dietas. Os resultados deste estudo sugerem que o uso de até 1,5% de uréia na MS da dieta de vacas em lactação não altera a produção, a composição e as características físico-químicas do leite.The objective of this trial was to evaluate the effects of three different dietary levels of urea on milk yield and composition. Nine lactating Holstein cows were randomly assigned to three replicated 3 x 3 Latin squares with three periods of 21 days each

  1. Consumo e digestibilidade total dos nutrientes e produção e composição do leite de vacas alimentadas com teores crescentes de proteína bruta na dieta contendo cana-de-açúcar e concentados Intake and total digestibility of nutrients and milk production and composition in dairy cows fed with increasing crude protein levels in the diet with sugar cane and concentrates

    Directory of Open Access Journals (Sweden)

    Carla Fabrícia de Araujo Cordeiro

    2007-12-01

    Full Text Available Objetivou-se avaliar o efeito de teores crescentes de PB na MS total da dieta (11,5; 13,0; 14,5 e 16,0% sobre os consumos e a digestibilidade total dos nutrientes e a produção e composição do leite de vacas leiteiras no terço inicial da lactação. O experimento foi constituído de quatro períodos experimentais de 15 dias, sete para adaptação dos animais à dieta e oito para coleta de dados. Foram utilizadas oito vacas, manejadas em cochos individuais, distribuídas em dois quadrados latinos balanceados 4 × 4. Utilizou-se concentrado à base de farelo de algodão e fubá de milho (40% e, como volumoso, cana-de-açúcar corrigida com 1% de uréia + sulfato de amônio (9:1, na proporção de 60% (% MS. Os consumos médios diários de nutrientes, exceto EE e CNF, diferiram à medida que os teores de PB da dieta aumentaram. Os teores de PB na dieta não afetaram os coeficientes de digestibilidade aparente total dos nutrientes. A produção de leite corrigida ou não para 3,5% de gordura e seus componentes (gordura, PB e lactose, expressa em g/dia, e o nitrogênio uréico no leite (NUL tiveram efeito linear crescente, enquanto a eficiência de utilização de N sofreu efeito linear negativo dos teores de PB da dieta. A dieta com 16% PB resultou em valores numericamente maiores de consumo e produção do leite e de seus componentes se comparada às dietas com menores teores de PB.The objective of this research was to evaluate the effect of increasing levels of CP in the total DM of diet (11.5, 13.0, 14.5 and 16.0% on the intakes and the total digestibility of nutrients and the milk production and composition of dairy cows in initial third of lactation. The research was constituted by four experimental periods of 15 days each, seven for adaptation of the animals to the diet and eight for data collection. Eight cows, individually fed, were distributed to two balanced 4 × 4 Latin squares. A cottonseed meal, ground corn-based concentrate (40

  2. High-mobility group box-1 protein (HMGB1) is increased in antineutrophilic cytoplasmatic antibody (ANCA)-associated vasculitis with renal manifestations.

    Science.gov (United States)

    Bruchfeld, Annette; Wendt, Mårten; Bratt, Johan; Qureshi, Abdul R; Chavan, Sangeeta; Tracey, Kevin J; Palmblad, Karin; Gunnarsson, Iva

    2011-01-01

    High-mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that is increasingly recognized as an important proinflammatory mediator actively secreted from monocytes and macrophages and passively released from necrotic cells. In antineutrophilic cytoplasmatic antibody (ANCA)-associated vasculitis (AAV), the kidneys are commonly affected vital organs, characterized by focal necrotizing and/or crescentic pauci-immune glomerulonephritis. The aim of the study was to determine whether HMGB1 serum levels are elevated in AAV with renal manifestations. A total of 30 AAV patients (16 female and 14 male; median age 59 years, range 17-82) with Wegener granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome with available renal biopsies and serum samples were included. In seven cases, serum was also obtained at rebiopsy in remission. HMGB1 was analyzed with Western blot. Birmingham Vasculitis Activity Score (BVAS, version 2003), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), urinanalysis, creatinine, estimated glomerular filtration rate, sex and age were included in the analysis. Twenty-five episodes of biopsy-proven active disease with BVAS 17.9 ± 4.6 and 13 cases with inactive biopsies and BVAS 2.3 ± 3.7 (P = 0.0001) were identified. CRP, ESR, hematuria and proteinuria were significantly higher in active cases. HMGB1 was significantly elevated (P = 0.01) comparing active with inactive cases (120 ± 48 versus 78 ± 46 ng/mL) and significantly lower in the seven control patients (P = 0.03) at rebiopsy in remission. HMGB1 remained higher in inactive cases compared with historic healthy controls (10.9 ± 10.5 ng/mL). HMGB1 levels did not differ significantly between AAV subgroups. CRP and ESR did not correlate with HMGB1. HMGB1 is significantly increased in AAV with renal involvement. Residual HMGB1 elevation in remission could possibly reflect low-grade inflammatory activity or tissue damage. Future studies may further reveal whether HMGB

  3. Produtividade do Capim-Cameroon estabelecida em duas classes de solos e submetido a doses crescentes de nitrogênio no norte tocantinense - doi: 10.4025/actascianimsci.v32i4.6209 Production of Cameroon grass in two soil classes with increasing nitrogen levels in the north of Tocantins State, Brazil - doi: 10.4025/actascianimsci.v32i4.6209

    Directory of Open Access Journals (Sweden)

    Diego Camargo Caraça

    2010-10-01

    Full Text Available Este estudo foi desenvolvido com o objetivo de avaliar o capim-elefante cv. Cameroon em função de doses de N em diferentes solos. Foi utilizado o delineamento experimental inteiramente casualizado em fatorial 5 x 2, sendo cinco doses de nitrogênio (0, 30, 60, 90, e 150 kg de N ha-1, testadas em duas classes de solo (Argissolo Vermelho eutroférrico típico e Neossolo Quartzarênico órtico típico, com quatro repetições. Os parâmetros avaliados foram: altura da planta, perfilhos, massa por perfilho, relação folha: colmo, matéria seca e pH do solo. Houve resposta positiva para ambos os solos, sendo a melhor resposta para o Argissolo. A massa dos perfilhos em gramas mostra efeito linear em função dos níveis de N e no Neossolo não houve diferença entre os tratamentos. O aumento da massa individual de perfilhos teve maior efeito na massa seca total. A adubação N promoveu acidificação linear decrescente maior no Argissolo. O desenvolvimento do capim, em função dos níveis crescentes de N apresentou resposta positiva para ambos os solos, sendo melhor para o Argissolo em comparação ao Neossolo.The development of elephant grass at increasing nitrogen rates in two soil classes was evaluated. A totally randomized 5 x 2 design, with five nitrogen levels (0, 30, 60, 90, and 150 kg N ha-1, in two classes of soil (Oxisol and Entisol, with four repetitions, was employed. Evaluated parameters consisted of plant height, tillers, mass per tiller, leaf:stem ratio, dry matter and pH of soil. Although the production of Pennisetum purpureum was positive for both types of soil, best response occurred in Oxisol. Whereas mass (in grams of the tillers had a linear effect according to nitrogen rates, there was no difference between treatments in Entisol. Increase of tillers’ mass had the highest effect on total dry mass. Nitrogen fertilization promoted highest decreasing acidification in Ultisol. Due to increasing levels of nitrogen the development

  4. Consumo, digestibilidade aparente total, produção e composição do leite em vacas no terço inicial da lactação alimentadas com níveis crescentes de proteína bruta no concentrado Intake, total apparent digestibility, milk production and composition in early lactation cows fed with increasing levels of crude protein in the concentrate

    Directory of Open Access Journals (Sweden)

    Mara Lúcia Albuquerque Pereira

    2005-06-01

    Full Text Available Avaliaram-se os consumos, as digestibilidades aparentes dos nutrientes e a produção e composição do leite de vacas no terço inicial da lactação recebendo dietas contendo níveis crescentes (20; 23; 26 e 29% da matéria natural - MN de proteína bruta (PB no concentrado. Foram utilizadas 12 vacas em lactação da raça Holandesa, puras e mestiças (Holandês x Zebu, distribuídas em três quadrados latinos (4x4. Foram utilizados quatro períodos de 15 dias cada, considerando-se uma semana de adaptação. A dieta consistiu de 60% de silagem de milho como volumoso e 40% de concentrado. Os consumos de matéria seca (MS, PB, fibra em detergente neutro (FDN e nutrientes digestíveis totais (NDT aumentaram linearmente, enquanto o consumo de carboidratos não-fibrosos (CNF apresentou redução linear com os níveis de PB no concentrado. As digestibilidades da MS, matéria orgânica (MO, PB e FDN elevaram linearmente em função dos teores de PB. A produção de leite (PL e PL corrigida para 3,5% de gordura, as quantidades de gordura e proteína e suas concentrações no leite não foram afetadas pelos níveis de PB no concentrado. No entanto, a PL corrigida para 3,5% de gordura de 29,08 kg/dia foi numericamente superior para o nível de 26% de PB na MN do concentrado. O concentrado contendo 26% de PB utilizado na proporção de 40%, que correspondeu a 15,5% na MS da dieta total, permitiu melhores respostas na produção de leite em vacas produzindo em média 28 kg/dia de leite no terço inicial da lactação e alimentadas com silagem de milho como volumoso.The intake, total apparent digestibility of nutrients and milk production and composition were evaluated in early lactation cows fed with increasing levels (20; 23; 26 and 29% natural matter - NM of crude protein (CP in concentrate. Twelve crossbred Holstein cows were assigned to three latin square (4x4, in four periods of 15 days each (one week of adaptation. The feeding consisted of 60% of

  5. Qualidade de ovos, parâmetros bioquímicos sanguíneos e desenvolvimento do aparelho reprodutor de poedeiras comerciais Lohmann LSL alimentadas com níveis crescentes de lisina digestível - DOI: 10.4025/actascianimsci.v30i1.3596 Egg quality, blood biochemical parameters and reproductive tract development for Lohmann LSL hens fed increasing levels of digestible lysine - DOI: 10.4025/actascianimsci.v30i1.3596

    Directory of Open Access Journals (Sweden)

    Anúzia Barini Nunes

    2008-06-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de lisina para poedeiras Lohmann LSL sobre a qualidade dos ovos, parâmetros bioquímicos sanguíneos e mensurações do aparelho reprodutor. Cento e sessenta poedeiras com 24 semanas foram submetidas a níveis crescentes de lisina digestível (600, 700, 800 e 900 mg Lys kg-1 de ração até 48 semanas de idade. As dietas foram isoenergéticas e isonutritivas com 15,8%PB e 2.800 kcal EM kg-1. Delineamento inteiramente casualizado foi adotado com quatro tratamentos e quatro repetições. Foram analisados: percentagem de casca, de gema e albúmen, gravidade específica dos ovos, unidade Haugh, índice gema, sólidos totais da gema, do albúmen e do ovo, parâmetros sanguíneos e mensuração do aparelho reprodutor. Os resultados foram submetidos à análise de variância e de regressão polinomial (5%, utilizando o programa SAS, e para os resultados sanguíneos e do aparelho reprodutor, foram analisados em esquema de parcelas subdivididas. Os níveis de lisina não influenciaram os resultados para qualidade dos ovos. Houve aumento no peso do aparelho reprodutor com o avançar da idade. Os resultados do parâmetro sanguíneo não foram influenciados; já nas semanas, observa-se aumento na albumina, uratos e uratina. O nível de 600 mg kg-1 pode ser recomendado para poedeiras no período avaliado.In this experiment, the effect of lysine levels on egg quality, biochemical parameters and measurements of the reproductive tract on the diets of Lohmann LSL laying hens diets were evaluated. One hundred-sixty hens with 24 weeks of age were submitted to increasing levels of digestible lysine (600, 700, 800 e 900 mg Lys kg-1 of feed until 48 weeks of age. The diets were isoenergetic and isonutritive. A completely randomized design was used, with four treatments and four replicates. Percentages of eggshell, yolk and albumen, specific egg gravity, yolk index, total yolk, albumen and egg solids, blood parameters

  6. Balanço de nitrogênio e perdas endógenas em bovinos e bubalinos alimentados com níveis crescentes de concentrado - DOI: 10.4025/actascianimsci.v29i4.1012 Nitrogen balance and endogenous losses in cattle and buffaloes fed with increasing levels of concentrate - DOI: 10.4025/actascianimsci.v29i4.1012

    Directory of Open Access Journals (Sweden)

    Ângela Maria Vieira Batista

    2008-03-01

    Full Text Available O trabalho objetivou avaliar as concentrações de uréia plasmática e urinária; o balanço dos compostos nitrogenados e estimar as exigências de proteína para mantença por equações preconizadas pelos sistemas americano e britânico, em quatro bovinos e quatro bubalinos, com peso médio inicial de 461,19 ± 7,59 e 455,44 ± 7,85 kg para os bovinos e búfalos, respectivamente, distribuídos em dois quadrados latinos 4 x 4. Os tratamentos consistiram em diferentes níveis de concentrado (0,0; 24,0; 48,0; 72,0% à base de milho moído, farelo de soja e sal mineral, e feno de capim-tifton. Cada período durou 21 dias, sendo 14 de adaptação e sete para coleta. Foram coletadas amostras de fezes e urina (spot para estimativa da produção de matéria seca fecal e volume urinário. Houve interação entre as espécies para nitrogênio (N consumido (NC, urinário (NU g kg-0,75 e uréia urinária (UU; não ocorrendo para N fecal (NF, N absorvido (NABS, NU (g d-1, balanço de N (BN e uréia plasmática (UP. Independente do efeito observado entre as espécies, as variáveis aumentaram linearmente em função dos níveis crescente de concentrado que proporcionou BN positivo. Os requerimentos de proteína metabolizável para mantença de bovinos e bubalinos, quando estimados por meio dos sistemas americano e britânico, são diferentes.The work aimed to evaluate the concentrations of plasmatic and urine urea, the balance of nitrogen compounds, and to estimate the protein requirements for maintenance. Equations recommended by the American and British systems were used in four bovine and four bubaline steers, with initial average weight of 461.19 ± 7.59 and 455.44 ± 7.85 kg for cattle and buffaloes, respectively, distributed into two 4 x 4 Latin squares. The treatments consisted of different levels of concentrate (0.0; 24.0; 48.0; and 72.0% composed of cracked corn, soybean meal, mineral salt, and Tifton-grass hay. Each period lasted 21 days, being

  7. Long-term Prognosis of Anti-Neutrophil Cytoplasmic Antibody-Negative Renal Vasculitis: Cohort Study in Korea.

    Science.gov (United States)

    Lee, Sung Woo; Yu, Mi-Yeon; Baek, Seon Ha; Ahn, Shin-Young; Kim, Sejoong; Na, Ki Young; Chae, Dong-Wan; Chin, Ho Jun

    2016-04-01

    Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5-2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Cox-proportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028-9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.

  8. Consumo, digestibilidade aparente total, produção e composição do leite em vacas no terço médio da lactação alimentadas com níveis crescentes de proteína bruta no concentrado Intake, total apparent digestibility, milk production and composition in mid lactation cows fed with increasing levels of crude protein in the concentrate

    Directory of Open Access Journals (Sweden)

    Mara Lúcia Albuquerque Pereira

    2005-06-01

    Full Text Available Avaliaram-se os consumos, as digestibilidades aparentes dos nutrientes e a produção e composição do leite de vacas no terço médio da lactação recebendo dietas contendo níveis crescentes de proteína bruta (PB no concentrado (20; 23; 26 e 29% da matéria natural - MN. Foram utilizadas 12 vacas em lactação da raça Holandesa, puras e mestiças, distribuídas em três quadrados latinos (4x4. Foram utilizados quatro períodos de 15 dias cada, sendo uma semana considerada de adaptação. A dieta consistiu de 70% de silagem de milho como volumoso e 30% de concentrado. Os consumos e as digestibilidades da matéria seca (MS, matéria orgânica (MO, extrato etéreo (EE, carboidratos totais (CHOT, fibra em detergente neutro (FDN e carboidratos não-fibrosos (CNF e o consumo de nutrientes digestíveis totais (NDT não foram alterados, enquanto o consumo e a digestibilidade de PB aumentaram em função dos níveis de PB no concentrado. A produção de leite (PL corrigida para 3,5% de gordura, as quantidades de gordura e proteína no leite aumentaram linearmente com o aumento dos níveis de PB no concentrado. No entanto, a PL de 19,21 kg/dia e a PL corrigida para 3,5% de gordura de 20,74 kg/dia para o nível de 23% de PB na MN do concentrado, foram muito próximas daquelas obtidas nos níveis de 26 e 29% de PB no concentrado. O concentrado contendo 23% de PB na MN utilizado na proporção de 30%, que correspondeu a 12,3% de PB na MS da dieta total, proporcionou melhor eficiência na produção de leite em vacas produzindo em média 20 kg/dia de leite no terço médio da lactação e alimentadas com silagem de milho na proporção de 70% na MS da dieta total.Intake, total apparent digestibility of nutrients and milk production and composition were evaluated in mid lactation cows fed with increasing levels of crude protein (CP in the concentrate (20, 23, 26 and 29% natural matter-NM. Twelve Holstein crossbred lactating cows were assigned to three

  9. Crescent marketing, Muslim geographies and brand Islam: reflections from the JIMA Senior Advisory Board

    OpenAIRE

    Wilson, Jonathan (Bilal) A.J.; Belk, Russell W.; Gary J Bamossy; Sandikci, Özlem; Kartajaya, Hermawan; Sobh, Rana; Liu, Jonathan; Scott, Linda

    2013-01-01

    Purpose – To bring together the thoughts and opinions of key members of the Journal of Islamic Marketing’s (JIMA) Editorial Team, regarding the recently branded phenomenon of Islamic marketing - in the interests of stimulating further erudition. Design/methodology/approach – The authors adopted an ‘eagle eye’ method to investigate this phenomenon: Where attempts were made to frame general principles and observations; alongside a swooping view of key anecdotal observations - in order to gr...

  10. Crescent marketing, Muslim geographies and brand Islam: reflections from the JIMA Senior Advisory Board

    OpenAIRE

    Wilson, Jonathan (Bilal) A.J.; Belk, Russell W.; Gary J Bamossy; Sandikci, Özlem; Kartajaya, Hermawan; Sobh, Rana; Liu, Jonathan; Scott, Linda

    2013-01-01

    Purpose – To bring together the thoughts and opinions of key members of the Journal of Islamic Marketing’s (JIMA) Editorial Team, regarding the recently branded phenomenon of Islamic marketing - in the interests of stimulating further erudition.\\ud \\ud Design/methodology/approach – The authors adopted an ‘eagle eye’ method to investigate this phenomenon: Where attempts were made to frame general principles and observations; alongside a swooping view of key anecdotal observations - in order to...

  11. A review of drug policy in the Golden Crescent: towards the development of more effective solutions.

    Science.gov (United States)

    Talpur, Anushka; George, Tony P

    2014-12-01

    There is a high prevalence of drug trafficking and misuse in Asia. Drugs grown in Afghanistan are trafficked through Iran and Pakistan to the rest of the world. This has led to an increase in the prevalence of drug use disorders in these regions, especially heroin. This has in turn led to an increase in the use of syringes and syringe sharing which has resulted in the exponential spread of blood borne diseases such as HIV/AIDS. A lack of awareness of the detrimental use of heroin, syringe sharing and the concept of HIV has been revealed. The literature reviewed provides evidence for a change in policy with an increase in epidemiological and clinical research in these regions as well as an increase in public awareness. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. crescent_city_1-3_arc-second_mhw.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  13. 76 FR 10918 - License Transfer Order for the Cimarron Facility at Crescent, OK

    Science.gov (United States)

    2011-02-28

    ... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... Kalman, Project Manager, Decommissioning and Uranium Recovery Licensing Directorate, Division of Waste... number 301-415-5369; e-mail: kenneth.kalman@nrc.gov . SUPPLEMENTARY INFORMATION: I. Introduction The...

  14. La Medialuna: un edificio para Chile/The Crescent, a building for Chile

    Directory of Open Access Journals (Sweden)

    Moreira Recchione, Alberto

    2007-12-01

    Full Text Available Se refiere los antecedentes históricos sobre la escuela ecuestre de la jineta y su introducción en las faenas agrícola-ganaderas chilenas. Se reseña el nacimiento del rodeo como deporte nacional chileno y los requerimientos del complejo espacio de la “fiesta del rodeo”: un problema arquitectónico y también urbanístico./ The equestrian school of "La Jineta" in Chile, and the architecture for the national holiday of "rodeo."

  15. ICT and Instructional Innovation: The Case of Crescent Girls' School in Singapore

    Science.gov (United States)

    Shear, Linda; Tan, Chen Kee; Patel, Deepa; Trinidad, Gucci; Koh, Richard; Png, Stephanie

    2014-01-01

    This paper describes a global professional development program called 21st Century Learning Design (21CLD), which helps teachers design academic lessons that integrate opportunities for students to develop 21st Century competencies in a variety of dimensions such as collaboration, knowledge construction, and the powerful use of ICT for learning.…

  16. Crescent Lake National Wildlife Refuge: A Report on Wilderness Character Monitoring

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is the completed effort of the U.S. Fish and Wildlife Service, Wilderness Fellows program to develop a monitoring strategy and evaluate the status of...

  17. China Confronts Afghan Drugs: Law Enforcement Views of The Golden Crescent

    Science.gov (United States)

    2011-03-01

    Illegal Drug Crimes in the Southwest Region and of the Policy Direction in Counternarcotics” (Shi lun Xibu diqu dupin fanzui de yanjun xingshi ji Jindu...Boyang, “On Counternarcotics Intelligence Cooperation in China’s Western Regions” (Lun xibu diqu de jindu qingbao xiezuo; 论西部毒品的进度情报协作), Journal of...and its Impact on Our Country’s Regional Stability,” (Zhongya dupin wenti de guojihua ji qi dui Woguo Diqu Wending de Yingxiang; 中亚毒品问题国际化及其对我国稳定的影

  18. Star and Crescent: Turco-Israeli Partnership in a Tough Neighborhood (Maxwell Paper, Number 22)

    Science.gov (United States)

    2000-08-01

    States); the up- grade of M-60 tanks and the sale of one thousand Merkava Mark III tanks; the sale of Popeye 1 air-to-surface missiles; and joint...production of Popeye 2 missiles. s2 Israel is aggressively seeking to further expand her mili- tary-industrial partnership with Turkey, offering sales and

  19. Consultorias em Sustentabilidade: polarizações e representatividades de um mercado crescente

    Directory of Open Access Journals (Sweden)

    Elisa Nogueira Novaes Botta

    2014-12-01

    Full Text Available O presente estudo pretende contribuir com o entendimento do surgimento e crescimento do mercado de Consultorias em Sustentabilidade no Brasil, bem como suas formas de organização. Ilustradas por um banco de dados e entrevistas, são apresentadas as principais características destas empresas brasileiras, bem como as formas de relacionamento com as consultorias internacionais. Ao final, apresenta-se uma cartografia dos polos de influência desse marcado, indicando algumas representatividades.

  20. Multibeam bathymetry data collected in 2016 for Lake Crescent in Olympic National Park, Washington

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — In February 2016 the U.S. Geological Survey, Pacific Coastal and Marine Science Center in cooperation with North Carolina State University and the National Park...

  1. Crescentic Glomerulonephritis with Anti-GBM and p-ANCA Antibodies

    Directory of Open Access Journals (Sweden)

    Tariq Javed

    2012-01-01

    Full Text Available We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. Patients with dual antibodies are considered to be a vasculitis-variant of anti-GBM antibody nephritis. These patients may have atypical presentation and it may delay diagnosis and treatment. Recurrence rate is higher in these patients. We reviewed the literature of cases and studies on cresenteric glomerulonephritis with anti-GBM and p-ANCA positive patients. We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence.

  2. Connective tissue growth factor and the cicatrization of cellular crescents in ANCA-associated glomerulonephritis

    NARCIS (Netherlands)

    Hilhorst, Marc; Kok, Helena M.; Broekhuizen, Roel; van Paassen, Pieter; van Breda Vriesman, Peter; Goldschmeding, Roel; Nguyen, Tri Q; Cohen Tervaert, Jan Willem

    2015-01-01

    BACKGROUND: Outcome in patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AGN) is difficult to predict. Scoring of renal biopsies has significant but limited predictive value. We investigated whether analysis of plasma and urine levels, and immunostaining of b

  3. crescent_city_1-3_arc-second_navd_88.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  4. The Nexus of Terrorism and Drug Trafficking in the Golden Crescent: Afghanistan

    Science.gov (United States)

    2006-03-15

    in Afghanistan. DEA Chief of Operations Michael A. Braun testified to Congress that it was "time for leadership" in Afghanistan. Braun 11 pointed to...February 2006. Figure 1 base map from http://edition.cnn.com/SPECIALS/2001 /trade.center/afghan.zoom.html; Internet accessed 8 February 2006. 20 Michael A...afg_intl_counter_narcotics_conf_2004.pdf; Internet; accessed 7 February 2006. 30 Nick Meo and Torcuil Crichton , "Afghanistan: We Were Told War Would Stem the Flood of Heroin into

  5. Crescent Lake/North Platte National Wildlife Refuge Complex 2005 annual habitat work plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual habitat management plan outlines working habitat objectives for wetland habitats based on refuge purposes, professional judgment and experience for...

  6. Application of Crescent-Shaped Brace passive resisting system in RC frame structures

    OpenAIRE

    Cimellaro, Gian Paolo; Kammouh, Omar

    2016-01-01

    The design of building structures that is capable of providing prescribed seismic performances is the fundamental objective of the Performance-Based Seismic Design (PBSD) approach. Matching a particular seismic response requires additional design freedom that the conventional structural elements (beam/column) fail to provide. Here, it is worth to highlight the role of innovative lateral resisting systems such as base isolation and dissipative systems, which can add flexibility to the design a...

  7. The Infertile Crescent Revisited: A Case (Study for the History of Archaeology

    Directory of Open Access Journals (Sweden)

    Jennifer Bracewell

    2015-05-01

    Full Text Available This paper examines the history of archaeological research concerning the eastern coast of James Bay in northern Quebec. The construction of prehistory in northern Quebec began with the earliest contact of Europeans with Native Canadians and developed from religious explanations to Classical Evolutionary ones to Culture-Historical ones to Neoevolutionary scientific ones. Although the theoretical interpretations changed over time, the content remained surprisingly constant. The challenges of research in the area, and the resulting paucity of data, led to generalizations that telescoped thousands of years and eight million square miles into a single interpretation, based largely on eighteenth- and nineteenth-century assumptions about hunter-gatherer mobility, subsistence and social evolution. This paper traces how these assumptions have affected the archaeology of the twentieth century in James Bay and northern Quebec.

  8. The Golden Crescent and HIV/AIDS in Central Asia: deadly interactions.

    Science.gov (United States)

    Beyrer, Chris

    2011-01-01

    Afghanistan has become the world's largest producer of illicit opiates. Opium and its derivative heroin are widespread substances of use, abuse and dependency in Central Asia. The region is currently undergoing expanding HIV epidemics driven largely by needle sharing among people who use drugs, in contexts where public health interventions to reduce the harms associated with substance use are limited by policy, law and legalistic and repressive approaches to drug users. Evidence-based approaches to drug treatment are lacking or limited in multiple states. Urgent reform is needed. The massive volumes of Afghan's illicit opiate exports are having serious impacts on the health of the region.

  9. The Shi’a Crescent: A Misconception of Shi’a Alliance

    Science.gov (United States)

    2014-12-01

    systems, agricultural care and foresting, and architecture. According to Aramajani, the Persian king who had the absolute power, followed a liberal...the banning of music and entertainment programs on television and radio, and the requirement of the hijab (Islamic dress) for women.”78 In addition to...Muslim sects, has a constitution that guarantees them absolute political power. On the socioeconomic level, once again Iraq’s geography and demography

  10. [Kidney allograft: a target for systemic disease].

    Science.gov (United States)

    Canaud, Guillaume; Legendre, Christophe

    2012-03-01

    Recurrence of disease after transplantation is frequent and represents the third cause of allograft loss. Recurrence of lupus nephritis after transplantation is rare. Kidney transplantation in patients with antiphospholipid syndrome or lupus anticoagulant is challenging due to the high risk of immediate post-transplant thrombosis and bleeding risk associated to the subsequent anticoagulation. Moreover, vascular changes associated to the presence of antiphospholipid antibodies negatively impact allograft rate survival. Recurrence of pauci immune glomerulonephritis or Goodpasture syndrome is exceptional. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  11. Misery Consciousness in The Crescent Moon%《月牙儿》的苦难意识

    Institute of Scientific and Technical Information of China (English)

    李玲

    2007-01-01

    通过辨析《月牙儿》文本的叙事特征,笔者认为《月牙儿》的主题是抒发自我生命悲感,而非控诉社会黑暗.文章由此进一步分析抒发生命悲感主题对母亲形象塑造的影响,分析叙述者"我"的自我封闭的心理特征.

  12. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis.

    NARCIS (Netherlands)

    Guo, J.; Menke, A.; Gubler, M.C.; Clarke, A.R.; Harrison, D.; Hammes, A.; Hastie, R.D.; Schedl, A.

    2002-01-01

    Glomerular disease is one of the most common causes of end-stage renal failure. Increasing evidence suggests that these glomerulopathies are frequently caused by primary lesions in the renal podocytes. One of the major consequences of podocyte lesions is the accumulation of mesangial matrix in the g

  13. From the Cross (and Crescent) to the Cedar and Back Again: Transnational Religion and Politics Among Lebanese Christians in Senegal

    Science.gov (United States)

    Leichtman, Mara A.

    2013-01-01

    This article examines the changing relationship between religion, secularism, national politics, and identity formation among Lebanese Christians in Senegal. Notre Dame du Liban, the first Lebanese religious institution in West Africa, draws on its Lebanese “national” character to accommodate Lebanese Maronite Catholic and Greek Orthodox Christians in Dakar, remaining an icon of “Lebanese” religion, yet departing from religious sectarianism in Lebanon. As such, transnational religion can vary from national religion, gaining new resonances and reinforcing a wider “secular” ethno-national identity. PMID:24077518

  14. PERFIL METABÓLICO EM OVINOS ALIMENTADOS COM INCLUSÕES CRESCENTES DA TORTA DO BABAÇU NA DIETA

    Directory of Open Access Journals (Sweden)

    Hemilly Menezes de Sá

    2014-07-01

    Full Text Available The objective was to evaluate the effect of inclusion of babassu pie in sheep feeding on the energy, protein and mineral metabolism, as well as, the effect of collection period on these variables.Twenty males intact sheep were assigned to four treatments, which were inclusion levels babassu pie (zero, 7.5%, 15%, 22.5% in the diet, according to completely randomized design, in split plot, where the parcels were diets and the subplots the collection times (zero, three, six, nine and twelve hours with five replications. There was no interaction between inclusion levels babassu pie and collection time for blood concentrations of total protein, albumin, uric acid, urea, triglycerides, phosphorus and magnesium. No effect of collection time on these variables (P0.05. Having regard to behavior presented by the metabolites analyzed, babassu pie can be used by up to 22.5% in sheep diet, since this level of inclusion does not cause metabolic disorders or reduction in energy, protein and mineral metabolism.

  15. Efeitos de concentrações crescentes de lidocaína hiperbárica, administradas no espaço subaracnóideo, sobre a medula espinhal e as meninges: estudo experimental em cães Efectos de concentraciones crecientes de lidocaína hiperbara, administradas en el espacio subaracnoideo, sobre la médula espinal y las meninges: estudio experimental en perros Effects of increasing spinal hyperbaric lidocaine concentrations on spinal cord and meninges: experimental study in dogs

    Directory of Open Access Journals (Sweden)

    Silvânia R.O. Pires

    2006-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Ainda não está bem estabelecida a concentração de lidocaína que é potencialmente capaz de determinar lesão no tecido nervoso. O objetivo desta pesquisa foi estudar os efeitos sobre a medula espinhal e as meninges, de concentrações crescentes de lidocaína administrada por via subaracnóidea, em injeção única através de agulha de Quincke. MÉTODO: Após a aprovação da Comissão de Ética em Experimentação Animal, 40 cães adultos foram anestesiados com fentanil e etomidato e submetidos a punção subaracnóidea com agulha de Quincke 22G 21/2 para introdução de 1 mL, em 10 segundos, de solução glicosada a 7,5% - Grupo 1; lidocaína a 5% em solução glicosada a 7,5% - Grupo 2; lidocaína a 7,5% em solução glicosada a 7,5% - Grupo 3; lidocaína a 10% em solução glicosada a 7,5% - Grupo 4. Após a recuperação da anestesia venosa, foram observados, no período em que os animais estavam em vigência do bloqueio subaracnóideo, a presença de bloqueio motor, o tônus do esfíncter anal (normal ou relaxado e o nível de bloqueio sensitivo nos diferentes dermátomos das regiões cervical, torácica, lombar e sacral. Os animais permaneceram em cativeiro por 72 horas. Foram avaliados o tônus do esfíncter anal, a motricidade das patas posteriores, a sensibilidade dolorosa nas patas anteriores e posteriores e nos dermátomos sacrais, lombares e torácicos. Após serem sacrificados por eletrocussão sob anestesia, foram retiradas porções lombar e sacral da medula espinhal e das meninges para exame histológico por microscopia óptica. RESULTADOS: Nenhum animal dos Grupos 1 e 2 apresentou lesões clínicas ou histológicas. Três animais do Grupo 3 apresentaram alterações motoras nas patas posteriores e relaxamento do esfíncter anal. Nestes, foram observados focos de necrose na região posterior (dois cães e necrose em faixa em toda a superfície medular (um cão. Em um outro animal deste grupo, no

  16. A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein

    Directory of Open Access Journals (Sweden)

    Osmundo B. Oliveira Neto

    2012-03-01

    Full Text Available Chagasin may be considered a potential plant-incorporated protectant (PIP protein due to its deleterious effects on insect pests. However, extensive safety studies with PIP's are necessary before introducing them into the target plant. Thus, a short-term feeding trial in rats with high doses of r-chagasin was conducted to provide evidences about its safety. Three test diets containing casein + r-chagasin (0.25, 0.5 and 1% of total protein were offered to rats (10 days. The test diets did not show adverse effects upon the development, organ weight, hematological parameters and serum protein profiles of rats, providing preliminary information on the safety of r-chagasin.Chagasina pode ser considerada como uma proteína com potencial para protetor incorporado a planta (PPI, devido aos seus efeitos deletérios sobre insetos praga. No entanto, estudos extensivos de segurança com PPI são necessários antes de introduzi-las na planta alvo. Assim, um experimento de alimentação de curto prazo em ratos com doses elevadas de r-chagasina foi conduzido para fornecer evidências sobre a sua segurança. Três dietas teste contendo caseína + r-chagasina (0,25; 0,5 e 1% de proteína total foram oferecidas aos ratos (10 dias. As dietas teste não apresentaram efeitos adversos sobre o desenvolvimento, o peso de órgãos, parâmetros hematológicos e perfis de proteínas séricas dos ratos, fornecendo informações preliminares sobre a segurança da r-chagasina.

  17. CONSERVAÇÃO DE INFLORESCÊNCIAS DE HELICÔNIAS PREVIAMENTE ADUBADAS COM DOSES CRESCENTES DE NITROGÊNIO E POTÁSSIO

    Directory of Open Access Journals (Sweden)

    GENILDA CANUTO AMARAL

    2015-01-01

    Full Text Available The post-harvest of floral stems is one of the main features observed in the production of flowers for cutting, becoming a prerequisite for product quality and successful marketing. In this sense, the objective was to evaluate the conservation of heliconias inflorescences with or without renewal of the water maintenance, previously fertilized with increasing doses of nitrogen and potassium. Inflorescences of Heliconia psittacorum x H. spathocircinata cultivar Golden Torch were used and grown in open conditions in the Floriculture area at UFPI, city of Bom Jesus, Piauí State under increasing doses of fertilization with N and K. The stems were harvested in the morning, standardized and placed in containers with 500 mL of water. The design was a randomized block in factorial 4 x 4 x 2, corresponding to: i N doses (0, 120, 180, and 240 g N hole-1 , ii K doses (0, 120, 180, and 240 g K2O hole-1 , and iii renewing the water maintenance in vase (with and without renewal with three replicates of three stems each. Some evaluations were observed during the Study, such as: the water uptake by the flower stems; loss of fresh weight of the flower stems, dry weight of the flower stems and post-harvest longevity. The dose of 180 g hole-1 both as N and K provided the longevity of the flower stems with quality maintenance. The absorption of water by the flower stems and its dry mass after harvesting are influenced by previous fertilizer N and K. The renewal of the water maintenance also positively influence the longevity of flower stems and its a management indicated to maintain quality post-harvest.

  18. Aerial Photography and Imagery, Ortho-Corrected, 2004 imagery over Eureka Township and Crescent Valley, unknown resolution, Published in 2004, Eureka County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Aerial Photography and Imagery, Ortho-Corrected dataset, was produced all or in part from Orthoimagery information as of 2004. It is described as '2004 imagery...

  19. BIOMETRIA TESTICULAR DE CORDEIROS EM DIFERENTES IDADES E ALIMENTADOS COM NÍVEIS CRESCENTES DE FIBRA EM DETERGENTE NEUTRO ORIUNDA DA FORRAGEM

    Directory of Open Access Journals (Sweden)

    Roberta Moura Assis

    2014-12-01

    Full Text Available The experiment was conducted at the Federal University of Lavras. We used 64 lambs, which, after birth, were divided into four treatments: Diet A - 8.67; Diet B - 17.34, Diet C - 26.01 and Diet D - 34.68% neutral detergent fiber from forage (NDFf in the diet. At three days of age, lambs were separated from their mothers and began receiving sheep milk replacer until weaning at 55 days. The experimental diets were isonitrogenous, formulated to meet the nutritional requirements of growing lambs, except for energy. Four digestibility diet essays were conducted for determining of metabolizable energy (ME at different ages (43, 83, 123 and 173 days of life. The biometric variables analyzed were weight, testis weight, scrotal circumference and volume. The experimental design was in randomized blocks (DBC, in a 4 x 4 factorial arrangement (four levels of dietary NDFf and four slaughter ages, with 4 replicates per treatment. The estimation of scrotal circumference by weight proved to be more efficient than in function of age. The prediction of the size and weight of the testes through scrotal circumference was more efficient than by the age and body weight. Animals fed diets with less fiber from forage, that is, with greater amount of energy, showed better results of testis biometry compared to the animals fed smaller amounts of energy.

  20. Draft final report : Relative abundance and diversity of birds in riparian habitats at North Platte National Wildlife refuge and in grasslands at Crescent Lake National Wildlife Refuge, Nebraska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — National Wildlife Refuges (NWRs) are among the few remaining tracts of land that have the potential for providing population-source habitats for many declining bird...

  1. Bioethanol: the new source for growing CO{sub 2} demand?; Bioetanol: a nova fonte para a demanda crescente por CO{sub 2}?

    Energy Technology Data Exchange (ETDEWEB)

    Martynowicz, Emile T.M.J. [Norit Haffmans, Venlo (Netherlands); Mekss, Varidots Dainis Thorvalds [Norit do Brasil Ltda., Sao Paulo, SP (Brazil)

    2009-11-01

    In recent years, while customers demand a more sustainable greener CO{sub 2} source, the worldwide demand for food-grade CO{sub 2} is steadily increasing. In Brazil, a large bio-ethanol producer, the CO{sub 2} from the bio-ethanol production is an alternative. The research focused on the activated carbon filter in a CO{sub 2} recovery plant in respect to its removal efficiency for sulfurous compounds, such as H{sub 2}S and COS. Five different types of activated carbons were investigated both in pilot scale tests as well as in full scale tests. The different adsorption behavior in respect to COS for the activated carbon was attributed to the variance in mineral trace element composition of the activated carbon. Finally, an activated carbon was selected, that could remove H{sub 2}S, DMS and COS concentrations in the low ppm range to levels of less than 20 ppbw, in even more than 50 thermal adsorption/desorption cycles. This activated carbon was tested in a full scale plant and proved to be very suitable for the process conditions encountered in a bioethanol plant. (author)

  2. Absorção e translocação de manganês por plantas de soja micorrizadas, sob doses crescentes deste nutriente

    Directory of Open Access Journals (Sweden)

    Cardoso E. J. B. N.

    2003-01-01

    Full Text Available A toxidez de Mn pode ser atenuada, em algumas situações, pela micorrização das plantas. Mecanismos diretos e indiretos podem estar envolvidos nesse processo. Este trabalho visou avaliar o efeito intrínseco do fungo micorrízico arbuscular (FMA na absorção e translocação de Mn por plantas de soja. Inicialmente, testaram-se três espécies de FMA quanto à capacidade de propiciar crescimento das plantas sob excesso de Mn. Glomus macrocarpum foi a mais eficiente em proteger as plantas contra o excesso de Mn, resultado da maior retenção de Mn nas raízes e menor translocação para a parte aérea. A simbiose com Gigaspora margarita foi ineficiente e limitou o desenvolvimento das plantas. Num segundo experimento, empregaram-se um cultivar tolerante e outro sensível ao excesso de Mn, em associação ou não com G. macrocarpum. Pretendeu-se verificar ocorrência de oxidação de Mn nas raízes das plantas micorrizadas, sob excesso de Mn. Não houve efeito da micorrização na oxidação de Mn nas raízes, mas na dose de 15 mg kg-1 de Mn, as plantas micorrizadas tiveram maior teor de Mn nas raízes. Houve efeito do cultivar, tendo o tolerante apresentado maior oxidação de Mn nas raízes.

  3. A kinematic model for the formation of the Siletz-Crescent forearc terrane by capture of coherent fragments of the Farallon and Resurrection plates

    Science.gov (United States)

    McCrory, Patricia A.; Wilson, Douglas S.

    2013-01-01

    The volcanic basement of the Oregon and Washington Coast ranges has been proposed to represent a pair of tracks of the Yellowstone hotspot formed at a mid-ocean ridge during the early Cenozoic. This interpretation has been questioned on many grounds, especially that the range of ages does not match the offshore spreading rates and that the presence of continental coarse clastic sediments is difficult to reconcile with fast convergence rates between the oceanic plates and North America. Updates to basement geochronology and plate motion history reveal that these objections are much less serious than when they were first raised. Forward plate kinematic modeling reveals that predicted basement ages can be consistent with the observed range of about 55–49 Ma, and that the entire basement terrane can form within about 300 km of continental sources for clastic sediments. This kinematic model indicates that there is no firm reason to reject the near-ridge hotspot hypothesis on the basis of plate motions. A novel element of the model is the Resurrection plate, previously proposed to exist between the Farallon and Kula plates. By including the defunct Resurrection plate in our reconstruction, we are able to model the Farallon hotspot track as docking against the Oregon subduction margin starting about 53 Ma, followed by docking of the Resurrection track to the north starting about 48 Ma. Accretion of the Farallon plate fragment and partial subduction of the Resurrection fragment complicates the three-dimensional structure of the modern Cascadia forearc. We interpret the so-called “E” layer beneath Vancouver Island to be part of the Resurrection fragment. Our new kinematic model of mobile terranes within the Paleogene North American plate boundary allows reinterpretation of the three-dimensional structure of the Cascadia forearc and its relationship to ongoing seismotectonic processes.

  4. Efeito de déficit hídrico transiente e doses crescentes de boro sobre a fertilidade de gemas de videira cv. Itália

    Directory of Open Access Journals (Sweden)

    Jorbas Sampaio de Melo

    2011-06-01

    Full Text Available O objetivo deste trabalho foi verificar o efeito de diferentes tensões de água no solo e diferentes concentrações de boro, na fertilidade de gemas de videira cv. Itália, manejada sob o sistema de poda mista. O experimento foi conduzido em pomar comercial, no município de Petrolina-PE. O delineamento experimental utilizado foi o de blocos ao acaso, em esquema fatorial 3x3: três tensões indicativas para a recarga hídrica por irrigação (-30 kPa, -50 kPa e -70 kPa e três concentrações de boro (3%, 6% e 9%, com três repetições e duas plantas por parcela. A testemunha não recebeu aplicações com boro e o solo foi mantido com umidade na capacidade de campo (-10 kPa. As variáveis analisadas foram fertilidade de gemas, índice relativo de clorofila (IRC e área foliar. Os dados foram interpretados por meio de análise de variância e regressão, e os modelos escolhidos com base na significância do coeficiente de regressão (R² > 0,70. Verificou-se que a fertilidade de gemas mostrou efeito linear negativo em função do aumento da tensão de água no solo, diminuindo de 31,88% (-30 kPa, para 23,66% (-70 kPa. Contudo, a fertilidade de gemas nas videiras submetidas a uma restrição hídrica de -30 kPa foi superior à tensão de -10 kPa; o boro a 3% propiciou a maior taxa de fertilidade de gemas em comparação aos demais tratamentos com boro; a restrição hídrica no solo a -30 kPa ocasionou economia no volume de água aplicada da ordem de 35,4% em comparação ao manejo com -10 kPa; o índice relativo de clorofila aumentou linearmente com o acréscimo das tensões de água no solo e houve maior expansão da área foliar em plantas submetidas ao manejo da irrigação na capacidade de campo.

  5. Red Crescent and its effect on the geography security on eastern borders (comparative study of social abnormalities during 1383-89

    Directory of Open Access Journals (Sweden)

    Farokh allah Shahbahrami

    2011-02-01

    Full Text Available Objective: drugs have some multidimensional effects on people and their lives. People who live in eastern provinces are at the risk of getting addicted and abnormal. Afghanistan is and has been the main problem for Iran. Method: this research has been done by library method and for this many books and articles have been read. The determined time was about 6 years. Findings: drugs have direct effects on life of people. Border cities are under the unkind effects of drugs and its relevant things. Conclusion: authorities must pay too much attention to drugs and eastern provinces

  6. The crescent and Islam: healing, nursing and the spiritual dimension. Some considerations towards an understanding of the Islamic perspectives on caring.

    Science.gov (United States)

    Rassool, G H

    2000-12-01

    Caring from Islamic perspectives is not well versed in Eurocentric nursing literature. There is widespread misunderstanding of the concept and practice of Islam within the context of health care and nursing practice. The areas of contention, in the context of health care systems, are whether the western paradigm to nursing care and management are applicable to Muslims and non-Muslims in both Islamic and non-Islamic countries. What is lacking in some of the conceptual frameworks and models of care is not only the fundamental spiritual dimension of care, but also the significance of spiritual development of the individual towards healing. The focus of this paper is to provide an awareness of Islamic health practices, health behaviours, code of ethics and the framework of Islamic perspectives of caring and spirituality. A brief overview of the Muslim world, the historical development in caring and health and the pillars of the Islamic faith provide the context of the paper. The development of a model of care based on the Islamic perspective is suggested.

  7. Incursão em pista: um risco potencial, atual e crescente nas operações = Runway incursion: a growing, actual and potential risk to operations

    Directory of Open Access Journals (Sweden)

    Fonseca, Wilber Campos

    2015-01-01

    Full Text Available Com a elevada demanda no tráfego aéreo, as incursões (acidentes em pista têm aumentado significativamente no mundo. Considerada como uma das mais graves ameaças à segurança operacional faz-se necessário saber o posicionamento das autoridades aeronáuticas em relação ao assunto, as medidas preventivas já implantadas e as que estão sendo pensadas para o futuro. O atual perfil dos pilotos é complexo e exige uma boa qualificação. No Brasil, a adoção do SMS (Sistema de Gerenciamento da Segurança, de novas tecnologias e a consciência situacional são meios de mitigar esse problema. Como o homem é o primeiro e principal elemento para a prevenção de tragédias, sem a sua cooperação todo trabalho é impensável. Assim, o objetivo principal deste artigo é apresentar informações técnicas e científicas atualizadas para propiciar um melhor entendimento acerca das peculiaridades que envolvem as preocupantes incursões em pista. Além disso, serão listadas algumas das mais modernas medidas tecnológicas que estão sendo implementadas como meios de prevenção de tais ocorrências

  8. Produtividade e valor nutritivo do capim-elefante cv. Napier sob doses crescentes de nitrogênio e potássio

    Directory of Open Access Journals (Sweden)

    Andrade Alex Carvalho

    2000-01-01

    Full Text Available Avaliaram-se os efeitos das adubações nitrogenada e potássica sobre o capim-elefante "Napier". Quatorze combinações entre N e K, de um fatorial incompleto de N e K, avaliados em sete doses de N (20, 50, 100, 200, 300, 350 e 380 kg/ha de N e sete de K (16, 40, 80, 160, 240, 280 e 304 kg/ha de K, foram obtidas de acordo com a matriz Box Berard aumentada 3, com acréscimo de um ponto. Os tratamentos foram distribuídos em blocos ao acaso com três repetições. A produtividade foi aumentada pelas adubações nitrogenada e potássica em 86%. A relação lâmina/colmo e o teor de Mg2+ diminuíram com a adubação potássica. Os teores de P e Ca2+ diminuíram com a adubação nitrogenada, enquanto o teor de proteína bruta aumentou de maneira quadrática pelas adubações nitrogenada e potássica. O teor de K aumentou com a adubação potássica e diminuiu com a nitrogenada. O nível crítico de potássio na planta foi 1,85 dag/kg na matéria seca.

  9. Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis.

    Science.gov (United States)

    Jarrot, Pierre-Andre; Chiche, Laurent; Hervier, Baptiste; Daniel, Laurent; Vuiblet, Vincent; Bardin, Nathalie; Bertin, Daniel; Terrier, Benjamin; Amoura, Zahir; Andrés, Emmanuel; Rondeau, Eric; Hamidou, Mohamed; Pennaforte, Jean-Loup; Halfon, Philippe; Daugas, Eric; Dussol, Bertrand; Puéchal, Xavier; Kaplanski, Gilles; Jourde-Chiche, Noemie

    2016-05-01

    The aim of the study was to report the clinical, biological, and pathological characteristics of patients with glomerulonephritis (GN) secondary to systemic lupus erythematosus (SLE)/antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) overlap syndrome.A nationwide survey was conducted to identify cases of SLE/AAV overlap syndrome. Data were collected from SLE and AAV French research groups. Inclusion criteria were diagnosis of both SLE and AAV according to international classification criteria and biopsy-proven GN between 1995 and 2014. Additional cases were identified through a systematic literature review. A cohort of consecutive biopsy-proven GN was used to study the prevalence of overlapping antibodies and/or overlap syndrome.The national survey identified 8 cases of SLE/AAV overlap syndrome. All patients were female; median age was 40 years. AAV occurred before SLE (n = 3), after (n = 3), or concomitantly (n = 2). Six patients had rapidly progressive GN and 3/8 had alveolar hemorrhage. All patients had antinuclear antibodies (ANA); 7/8 had p-ANCA antimyeloperoxidase (MPO) antibodies. Renal biopsies showed lupus nephritis (LN) or pauci-immune GN. Remission was obtained in 4/8 patients. A literature review identified 31 additional cases with a similarly severe presentation. In the GN cohort, ANCA positivity was found in 30% of LN, ANA positivity in 52% of pauci-immune GN, with no correlation with pathological findings. The estimated prevalence for SLE/AAV overlap syndrome was 2/101 (2%).In patients with GN, SLE/AAV overlap syndrome may occur but with a low prevalence. Most patients have an aggressive renal presentation, with usually both ANA and anti-MPO antibodies. Further studies are needed to assess shared pathogenesis and therapeutic options.

  10. Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis

    Science.gov (United States)

    Jarrot, Pierre-Andre; Chiche, Laurent; Hervier, Baptiste; Daniel, Laurent; Vuiblet, Vincent; Bardin, Nathalie; Bertin, Daniel; Terrier, Benjamin; Amoura, Zahir; Andrés, Emmanuel; Rondeau, Eric; Hamidou, Mohamed; Pennaforte, Jean-Loup; Halfon, Philippe; Daugas, Eric; Dussol, Bertrand; Puéchal, Xavier; Kaplanski, Gilles; Jourde-Chiche, Noemie

    2016-01-01

    Abstract The aim of the study was to report the clinical, biological, and pathological characteristics of patients with glomerulonephritis (GN) secondary to systemic lupus erythematosus (SLE)/antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) overlap syndrome. A nationwide survey was conducted to identify cases of SLE/AAV overlap syndrome. Data were collected from SLE and AAV French research groups. Inclusion criteria were diagnosis of both SLE and AAV according to international classification criteria and biopsy-proven GN between 1995 and 2014. Additional cases were identified through a systematic literature review. A cohort of consecutive biopsy-proven GN was used to study the prevalence of overlapping antibodies and/or overlap syndrome. The national survey identified 8 cases of SLE/AAV overlap syndrome. All patients were female; median age was 40 years. AAV occurred before SLE (n = 3), after (n = 3), or concomitantly (n = 2). Six patients had rapidly progressive GN and 3/8 had alveolar hemorrhage. All patients had antinuclear antibodies (ANA); 7/8 had p-ANCA antimyeloperoxidase (MPO) antibodies. Renal biopsies showed lupus nephritis (LN) or pauci-immune GN. Remission was obtained in 4/8 patients. A literature review identified 31 additional cases with a similarly severe presentation. In the GN cohort, ANCA positivity was found in 30% of LN, ANA positivity in 52% of pauci-immune GN, with no correlation with pathological findings. The estimated prevalence for SLE/AAV overlap syndrome was 2/101 (2%). In patients with GN, SLE/AAV overlap syndrome may occur but with a low prevalence. Most patients have an aggressive renal presentation, with usually both ANA and anti-MPO antibodies. Further studies are needed to assess shared pathogenesis and therapeutic options. PMID:27258503

  11. Wegener’s granulomatosis mimicking inflammatory bowel disease and presenting with chronic enteritis

    Directory of Open Access Journals (Sweden)

    Shahedi K

    2013-10-01

    Full Text Available Kamyar Shahedi,1,2 Ramy Magdy Hanna,1,2 Oleg Melamed,1,2 James Wilson2,31Department of Medicine Olive-View UCLA Medical Center, Sylmar, CA, 2David Geffen School of Medicine at UCLA, Los Angeles, CA, 3UCLA Medical Center-UCLA Stone Center, Los Angeles, CA, USAAbstract: Wegener’s granulomatosis, also known as anti-neutrophil cytoplasmic antibody (ANCA-associated vasculitis, is a small vessel vasculitis with primarily pulmonary, renal, and sinus disease manifestations. The prevalence of Wegener’s granulomatosis is three cases per 100,000 patients. Cardiovascular, neurologic, cutaneous, and joint manifestations have been reported in many case reports and case series. Gastrointestinal manifestations are less noted in Wegener’s granulomatosis, although they have been previously reported in the form of intestinal perforation and intestinal ischemia. Additionally, there are characteristic findings of vasculitis that are noted with active Wegener’s granulomatosis of the small bowel. We report a case of an elderly patient who presented with weight loss, diarrhea, and hematochezia. His symptoms were chronic and had lasted for more than 1 year before diagnosis. Inflammatory bowel disease or chronic enteritis due to Salmonella arizonae because of reptile exposure originally were suspected as etiologies of his presentation. The findings of proteinuria, renal failure, and pauci-immune glomerulonephritis on renal biopsy, in conjunction with an elevated c-ANCA titer, confirmed the diagnosis of Wegener’s granulomatosis with associated intestinal vasculitis. This case demonstrates an atypical presentation of chronic duodenitis and jejunitis secondary to Wegener’s granulomatosis, which mimicked inflammatory bowel disease.Keywords: ANCA-associated vasculitis, Wegener’s syndrome, pauci-immune glomerulonephritis, Salmonella arizonae, inflammatory bowel disease

  12. 78 FR 31909 - Notice of Intent To Prepare an Environmental Impact Statement for Military Readiness Activities...

    Science.gov (United States)

    2013-05-28

    .... Tuesday, June 11, 2013, at Crescent Valley Town Office Boardroom, 5045 Tenabo Avenue, Crescent Valley... resources, geology, soils and water resources, land use and recreation, air quality, noise,...

  13. Alterações bromatológicas nas silagens de milho submetidas a crescentes tempos de exposição ao ar após "desensilagem"

    Directory of Open Access Journals (Sweden)

    Velho João Pedro

    2006-01-01

    Full Text Available O experimento foi conduzido em delineamento completamente casualizado, com o objetivo de avaliar os efeitos da exposição de uma silagem ao ar por zero, 12, 24 e 36 horas após a "desensilagem". A ensilagem de um cultivo de milho "safrinha" foi realizada no dia 18/05/2004 em mini-silos com capacidade de 30 litros, com quatro repetições por tratamento, quando os grãos de milho se encontravam no estádio fraction one-half leitoso fraction one-half farináceo. Os diferentes tempos de exposição ao ar após a "desensilagem" afetaram significativamente (P<0,05 o teor de fibra em detergente neutro, corrigido para cinzas e proteínas, e o teor de lignina em ácido sulfúrico. Não houve efeito nos carboidratos não estruturais e nas frações nitrogenadas. Conclui-se que um período de 12 horas de aerobiose, após a "desensilagem", afeta o valor nutritivo das silagens de milho.

  14. Effects of increasing use of trifluralin and glyphosate on the microbial activity of a lea soil; Efeito de doses crescentes dos herbicidas trifluralina e glifosato sobre a atividade microbiana de um solo de varzea

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Edna Santos de; Monteiro, Regina Teresa Rosim [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil); Peixoto, Maria de Fatima da Silva Pinto [Sao Paulo Univ., Piracicaba, SP (Brazil). Escola Superior de Agricultura Luiz de Queiroz. Dept. de Quimica. E-mail: mfsppeix@carpa.ciagri.usp.br; Fay, Elizabeth Francisconi [Empresa Brasileira de Pesquisa Agropecuaria, Jaguariuna, SP (Brazil). Centro Nacional de Pesquisa de Defesa da Agricultura. E-mail: bethfay@cnpma.embrapa.com.br

    1997-07-01

    This work considers the importance of the glyphosate and trifluralin, which are the most used herbicides by the brazilian plantations, applying approximately fifteen and nine millions of liters by crop, respectively, for the evaluation of the increasing use of these herbicides effects on the microbial activity of a lea soil which are used for beans cultivation.

  15. EVIDENCE FOR THE CRESCENT VALLEY-INDEPENDENCE LINEAMENT, NORTH-CENTRAL NAVADA U.S.%内华达北中部新月谷--独立金矿区线性构造带的证据

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    内华达北中部的新月谷-独立金矿区线性构造(CVIL)是一个呈20°~30°走向、具多期变形、侵入及热液活动的构造带,该带从独立金矿区向南至科特兹矿山附近延伸达90 km,经过科特兹-派普来恩、卡林及独立三个主要的沉积岩型金矿区,含有罗伯茨山异地岩(可能是奥陶系Vinini组)的强烈构造岩,NE向的断层,白垩或第三纪的NE向的岩墙.变形带的组构具混杂岩的特点,但混杂岩中也显示有与晚三叠世和晚侏罗世之间形成的褶皱展布方向一致的定向组构.此外,沿CVIL带局部出现有第三纪的碧玉状岩石、角砾岩、方解石脉及脱钙蚀变作用.CVIL构造带南北两端成群出现的沉积岩型金矿床具有与卡林矿带金矿床相同的矿物特征.上述二个矿区都有NE向的断层,穿越罗伯茨山异地岩上盘中的构造窗和构造高地.CVIL可能是形成某些金矿床的主要热液通道.

  16. 水电站非对称月牙肋岔管体型生成系统开发%System Development of Somatotype Generation for Hydropower Station Asymmetric Crescent-Rib Reinforced Branch Pipe

    Institute of Scientific and Technical Information of China (English)

    李斌; 宋海亭; 白正雄

    2016-01-01

    针对水电站非对称月牙肋岔管结构体型、空间关系复杂,手算方法设计工作量大、设计效率不高的问题,根据新的水电站压力钢管设计规范对岔管体型提出的要求,从程序开发的角度出发,从各圆锥的几何关系入手,重新推导了相关公式,解决了体型生成中的关键问题;应用C++语言编制非对称月牙肋岔管的体型生成程序,采用VTK图形库实现了系统的三维可视化功能。工程应用实例表明,该系统数据输入简单,人机交互性和可操作性好,输出体型方案齐全,能够将岔管体形设计和绘制设计图很好地结合起来,为月牙肋岔管的设计提供了一个方便可靠的工具。%For the complicated issues of somatotype of hydropower station asymmetric crescent⁃rib reinforced branch pipe, rather difficult spatial relationship to be imagined, huge design workload by means of manual computation and lower design efficiency, it had been re⁃deduced the relevant formula to solve key problems during the somatotype generation, from the angle of program development, which matched the requirements for branch pipe somatotype from the new design criterion of hydropower station pressure steel tube and began with the geometric relation of various tapers;it had been accomplished the somatotype development program of asymmetric crescent⁃rib reinforced branch pipe by employing C++Language and produced the 3D systematic visual function by employing the VTK graphic library. According to the engineering application examples, the system data input is simple, with perfect human computer interaction and good operability, and the output somatotype plan is complete enough to provide a convenient reliable tool for designing the crescent⁃rib reinforced branch pipe, which can wonderfully combine the branch pipe somatotype design with the drawing design figure.

  17. National Dam Inspection Program. Crescent Lake Dam (NDI-ID Number PA-00413, DER-ID 52-142) Delaware River Basin, Pike County, Pennsylvania. Phase I Inspection Report.

    Science.gov (United States)

    1980-06-01

    CRESPIT LAhE SUPAREA ISIAO ICOMP - IECUN ITAFL J’LT-- JPRT INAhE ISTAGE IAUTO. 8 0 0 0 0 0 1 0 0 HYDROGRAPH DAIA IHYOG IUHG TAREA SNAP TRSPA TrNSC RATIO...T A 1 CUMF, IECIN I I At-, JftT JPRT INAhE ISTtAGE IUO 10 1 1) 0 0 0 1 0 0 knUl1Nli 1,AIs DLOS CLOK-S AI., G IREq ISAIIt IOPT IFPF LSiN 0.0 0.000 0.00

  18. A crescente importância das universidades e institutos públicos de pesquisa no processo de catching-up tecnológico The increasing importance of universities and public research institutions in the catching-up process

    Directory of Open Access Journals (Sweden)

    Luciano Martins Costa Póvoa

    2008-08-01

    Full Text Available O objetivo deste artigo é analisar como as universidades e os institutos públicos de pesquisa podem contribuir para o avanço tecnológico de países em de-senvolvimento e apresentar argumentos que sugerem que a importância desses agentes tem aumentado com os recentes paradigmas tecnológicos e o fortalecimento da proteção à propriedade intelectual no cenário internacional. Para tanto, são discutidas as relações entre ciência e tecnologia e as características presentes nas experiências de catching-up de sucesso.The aim of this paper is to analyze the role of universities and public research institutions in the process of technical catch-up and to discuss how their importance have increased along the last century due to the new technological para-digms and international intellectual property rights rules. The relationship between science and technology is investigated as well as the common characteristics in the success experiences of catching-up.

  19. Sevoflurano e desflurano sobre o ritmo cardíaco de cães tratados com infusão contínua de doses crescentes de adrenalina

    Directory of Open Access Journals (Sweden)

    Nunes Newton

    2004-01-01

    Full Text Available Os anestésicos inalatórios sensibilizam o miocárdio ou seu sistema de condução à ação das catecolaminas endógenas e/ou exógenas, predispondo o animal às arritmias cardíacas. Dentre os anestésicos voláteis, o sevoflurano e o desflurano são fármacos relativamente recentes e, embora sejam dotados de características relacionadas a não sensibilização do miocárdio às catecolaminas, desconhecem-se estudos que comparem suas eventuais propriedades antiarritmogênicas. Com o objetivo de estudar, comparativamente, o comportamento do ritmo cardíaco e observar eventuais bloqueios atrioventriculares em cães anestesiados pelo sevoflurano e desflurano e submetidos à infusão contínua de adrenalina, foram utilizados 20 animais adultos, os quais foram separados em dois grupos de igual número (G1 e G2. Aos cães do G1, foi administrado propofol, na dose média de 10mmg.kg-1; em seguida os animais receberam sevoflurano, a 1,5CAM. Decorridos 30 minutos do início da administração do anestésico volátil, iniciou-se a infusão de adrenalina na dose de 1mmg.kg-1.min-1. A cada 10 minutos, a dose da catecolamina foi acrescida em uma unidade, cessando-se a administração em 6mmg.kg-1.min-1. Para o G2, empregou-se a mesma metodologia, substituindo-se o sevoflurano pelo desflurano, administrado a 1,5CAM. A cada dose de adrenalina, foi feita contagem de batimentos ventriculares ectópicos, bem como a observação de bloqueios atrioventriculares. Os achados foram tratados pelos métodos estatísticos de Análise de Perfil e Kruskall-Wallis. Os resultados permitiram concluir que o desflurano minimiza de maneira mais eficiente a arritmia induzida pela adrenalina, além de reduzir a incidência de bloqueios atrioventriculares.

  20. Desempenho de perus de corte alimentados com níveis crescentes de aflatoxinas, com ou sem adição de adsorvente Turkey performance fed with increasing aflatoxins levels, with or without adsorvent inclusion

    Directory of Open Access Journals (Sweden)

    Janio Morais Santurio

    1998-03-01

    Full Text Available Este trabalho foi realizado durante o verão de 1995/96 com o objetivo de determinar o nível de aflatoxinas (AFL capaz de causar prejuízos no desempenho de perus de corte criados sob condições ambientais de baixo desafio, bem como avaliar a eficácia da adição de bentonita sódica natural (BSN como um adsorvente. Foram utilizados 1008 perus de corte, alojados em 84 boxes seguindo um delineamento experimental de blocos casualizados com 14 tratamentos distribuídos em um arranjo fatorial 7x2, sendo 7 níveis de adição de AFL, (0, 10, 50, 100, 500, 1000 e 2000ppb e 2 níveis de adição de BSN (0 e 0,5%. Aos 21 dias de idade, as aves alimentadas com as dietas sem adição de BSN mostraram uma redução significativa (PThis experiment was carried out in the 1995/96 summer to determine the aflatoxin (AFL levels ability to decrease turkey performance raised under excellent environmental conditions and also to avaluate a natural sodium bentonite (NSB efficiency as an adsorbent. One thousand and eight poults were housed in 84 floor pens following a randomized complete block design with 14 treatments arranged in a 7x2 factorial, with 7 AFL levels (0, 10, 50, 100, 500, 1000 and 2000ppb and 2 NSB levels (0 and 0.5%. At 21 days of age the birds fed without NSB showed body weight gain (BWG and feed intake (FI reduction (P<0.05 from 500ppb or more of AFL, whereas the birds fed with NSB showed BWG and FI reduction (P<0.05 only from 1000ppb or more of AFL. These same results were observed at 40 days of age, but at 70 days, the BWG and FI reduction was statistically significant (P<0.05 from 500ppb or more of AFL, with or without NSB inclusion. In general, birds fed with NSB had about 15 to 20% less BWG and FI reduction than birds fed without NSB. The feed conversion (FC was less affected by AFL levels, although it worsened with increasing AFL levels. AFL have greatly affected the mortality rate. At 21 days of age the birds fed with 1000 and 2000pbb of AFL have already presented 15.3 and 72.2% of mortality, respectively and until 40 days all birds fed with 2000ppb of AFL died. However there was a benefic effect of NSB inclusion. Based on theses results can be concluded that AFL are highly deleterious for turkey and that NSB can partialy protect the birds from AFL negativo effects.

  1. Níveis Crescente de Zeólitas (Clinoptilolita) e Vucca schidigera em Rações de Cães - Influência na Digestibilidade e Escore Fecal

    OpenAIRE

    Maia, Gustavo Vaz Corrêa; Departamento de Zootecnia/UFLA – Campus Universitário s/n, Lavras-MG; Saad, Flávia Borges; Departamento de Zootecnia/UFLA – Campus Universitário s/n, Lavras-MG; Chizzotti, Ana Flávia; Dep. Zootecnia/UFLA – Campus Universitário s/n, Lavras-MG; Benitez, Bárbara Carriel; Departamento de Zootecnia/UFLA – Campus Universitário s/n, Lavras-MG; Santos, João Paulo Fernandes; Departamento de Zootecnia/UFLA – Campus Universitário s/n, Lavras-MG; Aquino, Adriana Augusto; Departamento de Zootecnia/UFLA – Campus Universitário s/n, Lavras-MG

    2013-01-01

    Melhorias na digestibilidade do alimento e no escore fecal podem ser alcançadas com formulações de alto valor nutritivo ou pela inclusão de certos aditivos. O objetivo deste trabalho foi determinar a interferência dos aditivos extrato de Yucca schidigera (YSE) e Zeólita (Clinoptilolita), na digestibilidade de rações comerciais e sua ação na capacidade de melhoria do escore fecal de cães. O estudo foi realizado na Universidade Federal de Lavras utilizando 21 cães adultos da raça Beagle com pes...

  2. Salinity tolerance of halophyte Atriplex nummularia L. grown under increasing NaCl levels Tolerância à salinidade da halófita Atriplex nummularia L. cultivada em níveis crescentes de NaCl

    Directory of Open Access Journals (Sweden)

    Sandro A.M. de Araújo

    2006-12-01

    Full Text Available The current study reports effects of salt stress on growth, K+ nutrition and organic composition of Atriplex nummularia. The upper limit of the NaCl gradient imposed on the plants was close to seawater salinity (600 mM. An external NaCl of 150 mM improved the growth of this species, which corroborates its halophytic nature. Evidence show that Atriplex nummularia was responsive to NaCl, but the mechanisms of this response are still not known. In such stress condition, Na+ and Cl- accumulation in leaves was far greater than that in roots; therefore salinity tolerance of Atriplex nummularia is not due to ion exclusion mechanism. In spite of a reduction of K+ content of tissues under salinity conditions, no corresponding physiological relevance of this in terms of growth was found. The high affinity of root cells for Na+ during uptake and, probably, its subsequent sequestration into cell vacuoles and structures of protection seems to contribute to osmotic adjustment as an increase in relative water content (RWC of leaves was observed. NaCl caused a decrease in total soluble proteins and chlorophylls; the relevance of this is discussed in terms of mechanisms of salinity tolerance. The ability of Atriplex nummularia plants to keep Na+ and Cl- away from enzymes and cytosolic structures, together with an effective osmotic adjustment, is suggested as having a role in its tolerance to high salinity.O presente estudo relata os efeitos do estresse salino no crescimento, na nutrição de K+ e na composição orgânica de Atriplex nummularia. A maior concentração de NaCl imposta às plantas foi similar a da salinidade da água do mar (600 mM. Uma concentração externa de 150 mM de NaCl estimulou o crescimento da espécie o que, em parte, explica seu caráter halofítico. As evidências mostram que a Atriplex nummularia foi receptiva ao NaCl, porém os mecanismos envolvidos são ainda esperados. Em tais condições de estresse a acumulação de Na+ e Cl- nas folhas foi superior à das raízes, mostrando que a tolerância à salinidade da Atriplex nummularia não é devida ao mecanismo de exclusão de íons. Apesar do conteúdo de K+ nos tecidos ter sido reduzido pela salinidade, nenhuma relevância fisiológica deste fato foi observada em termos de crescimento das plantas. A alta afinidade das raízes por Na+ durante a absorção e, provavelmente, seu subseqüente seqüestro em células do vacúolo e estruturas de proteção, parece ter contribuído no ajustamento osmótico, como atesta o aumento observado no conteúdo relativo de água das folhas (RWC. O NaCl causou decréscimo nas proteínas totais e clorofilas, cuja relevância é discutida em termos de mecanismos de resistência à salinidade. A habilidade da Atriplex nummularia em manter Na+ e Cl- longe das enzimas e das estruturas citosólicas, associada a um efetivo ajustamento osmótico, é sugerida por apresentar importante papel em sua tolerância à salinidade.

  3. Câncer de mama: mortalidade crescente na Região Sul do Brasil entre 1980 e 2002 Increase in breast cancer mortality in Southern Brazil from 1980 to 2002

    Directory of Open Access Journals (Sweden)

    Andrea T. Cadaval Gonçalves

    2007-08-01

    Full Text Available O câncer de mama é apontado como o tipo de câncer mais prevalente no mundo. No Brasil, as taxas de mortalidade por câncer de mama continuam elevadas, observando-se diferenças inter-regionais. Foi realizado um estudo ecológico de série temporal (1980-2002 na Região Sul, com dados anuais do Departamento de Informação e Informática do SUS (DATASUS, para avaliar o comportamento do coeficiente de mortalidade por câncer de mama, padronizado por idade. Utilizou-se regressão linear simples e múltipla para estimar as taxas de mortalidade e as diferenças entre os três Estados. O Rio Grande do Sul parte de um patamar mais elevado e apresenta maior taxa média de mortalidade (14,45, sendo significativamente diferente (p Breast cancer is the most prevalent form of cancer in the world. Breast cancer mortality rates are high in Brazil and show striking variations between geographic regions. A time-trend ecological study was performed in Southern Brazil from 1980 to 2002. Data were collected from the Mortality Information System (Ministry of Health to assess age-standardized mortality rates. Linear regression for mortality time-trend analysis and multiple regression for mortality differences among three States were calculated. The highest mean mortality rate (14.45 was observed in Rio Grande do Sul, significantly greater (p < 0.001 than in Santa Catarina (8.93 and Paraná (9.95. An annual increase of 0.47 in the mortality rate was observed in the three States of Southern Brazil. According to these results, the South of Brazil and especially the State of Rio Grande do Sul showed a significant upward trend in breast cancer mortality. Continued efforts are needed to help explain these numbers and reverse the present situation.

  4. Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

    LENUS (Irish Health Repository)

    Little, Mark A

    2012-01-01

    Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener\\'s granulomatosis). Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on murine neutrophils, and by different Fc-receptor affinities for IgG across species. Therefore, we tested whether human anti-PR3 antibodies can induce acute vasculitis in mice with a human immune system. Chimeric mice were generated by injecting human haematopoietic stem cells into irradiated NOD-scid-IL2Rγ⁻\\/⁻ mice. Matched chimera mice were treated with human IgG from patients with: anti-PR3 positive renal and lung vasculitis; patients with non-vasculitic renal disease; or healthy controls. Six-days later, 39% of anti-PR3 treated mice had haematuria, compared with none of controls. There was punctate bleeding on the surface of lungs of anti-PR3 treated animals, with histological evidence of vasculitis and haemorrhage. Anti-PR3 treated mice had mild pauci-immune proliferative glomerulonephritis, with infiltration of human and mouse leukocytes. In 3 mice (17%) more severe glomerular injury was present. There were no glomerular changes in controls. Human IgG from patients with anti-PR3 autoantibodies is therefore pathogenic. This model of anti-PR3 antibody-mediated vasculitis may be useful in dissecting mechanisms of microvascular injury.

  5. Paquimeningitis hipertrófica, glomerulonefritis y vasculitis de pequeños vasos asociada a ANCA Hypertrophic pachymeningitis, glomerulonephritis and P-ANCA associated small vessel vasculitis

    Directory of Open Access Journals (Sweden)

    Octavio Mazzocchi

    2007-04-01

    Full Text Available La paquimeningitis hipertrófica es una enfermedad poco frecuente caracterizada por engrosamiento de la duramadre. Presentamos una paciente con esta enfermedad que se manifestó con cefalea crónica y en la que concomitantemente se evidenció una glomerulonefritis necrotizante extracapilar pauciinmune asociada a anticuerpos anticitoplasma de neutrófilos de patrón perinuclear (ANCA-P. El diagnóstico se estableció por resonancia nuclear magnética. Recibió tratamiento inmunosupresor con prednisona y ciclofosfamida con evolución favorable.Hypertrophic pachymeningitis is a very unusual disease, the main characteristic of which is thickening of the dura mater. We describe a patient who started this illness showing chronic headache and pauci-immune necrotizing extracapillary perinuclear antineutrophil cytoplasmic antibody (P-ANCA associated glomerulonephritis. The diagnosis was made by brain magnetic resonance image. She received immunosuppressant therapy with prednisonel and cyclophosphamide with clinical improvement.

  6. Systemic vasculitis associated with vemurafenib treatment

    Science.gov (United States)

    Mirouse, Adrien; Savey, Léa; Domont, Fanny; Comarmond, Cloé; Barete, Stéphane; Plaisier, Emmanuelle; Rouvier, Philippe; Cacoub, Patrice; Saadoun, David

    2016-01-01

    Abstract Rationale: Vemurafenib, an inhibitor of mutated B-rapidly accelerated fibrosarcoma, is frequently used in the treatment of melanoma and Erdheim–Chester disease (ECD) patients. Inflammatory adverse effects have been increasingly reported after vemurafenib treatment. Patient concerns and diagnose: We report 6 cases of vemurafenib-associated vasculitis, of whom a personal case of a 75-year-old man with history of ECD who developed purpura and rapidly progressive pauci-immune glomerulonephritis during treatment with vemurafenib. Intervention: In the 5 others cases from the literature, all patients presented skin vasculitis, and with joint involvement in 60% of them. Vemurafenib treatment was stopped (n = 3), continued at reduced doses (n = 1), or continued at the same dose (n = 2). Outcomes: Three patients (50%) received corticosteroids combined with cyclophosphamide (n = 1), and all achieved remission of vasculitis. One patient experienced vasculitis relapse after vemurafenib therapy was restarted. Lessons: Systemic vasculitis is a rare vemurafenib-associated adverse event that may be life-threatening. PMID:27861332

  7. Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

    Directory of Open Access Journals (Sweden)

    Mark A Little

    Full Text Available Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3 antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis. Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on murine neutrophils, and by different Fc-receptor affinities for IgG across species. Therefore, we tested whether human anti-PR3 antibodies can induce acute vasculitis in mice with a human immune system. Chimeric mice were generated by injecting human haematopoietic stem cells into irradiated NOD-scid-IL2Rγ⁻/⁻ mice. Matched chimera mice were treated with human IgG from patients with: anti-PR3 positive renal and lung vasculitis; patients with non-vasculitic renal disease; or healthy controls. Six-days later, 39% of anti-PR3 treated mice had haematuria, compared with none of controls. There was punctate bleeding on the surface of lungs of anti-PR3 treated animals, with histological evidence of vasculitis and haemorrhage. Anti-PR3 treated mice had mild pauci-immune proliferative glomerulonephritis, with infiltration of human and mouse leukocytes. In 3 mice (17% more severe glomerular injury was present. There were no glomerular changes in controls. Human IgG from patients with anti-PR3 autoantibodies is therefore pathogenic. This model of anti-PR3 antibody-mediated vasculitis may be useful in dissecting mechanisms of microvascular injury.

  8. Effects of Aging on Parasite Biomass, Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Plasmodium knowlesi and Plasmodium falciparum Malaria.

    Science.gov (United States)

    Barber, Bridget E; Grigg, Matthew J; William, Timothy; Piera, Kim A; Boyle, Michelle J; Yeo, Tsin W; Anstey, Nicholas M

    2017-06-15

    In populations pauci-immune to malaria, risk of severe malaria increases with age. This is particularly apparent in Plasmodium knowlesi malaria. However, pathophysiological mechanisms underlying knowlesi malaria, and of the age-related increase in risk of severe malaria in general, are poorly understood. In Malaysian patients aged ≥12 years with severe (n = 47) and nonsevere (n = 99) knowlesi malaria, severe (n = 21) and nonsevere (n = 109) falciparum malaria, and healthy controls (n = 50), we measured parasite biomass, systemic inflammation (interleukin 6 [IL-6]), endothelial activation (angiopoietin-2), and microvascular function, and evaluated the effects of age. Plasmodium knowlesi parasitemia correlated with age (Spearman's correlation coefficient [rs] = 0.36; P falciparum malaria, angiopoietin-2 increased with age, independent of parasite biomass (histidine-rich protein 2 [HRP2]). Independent risk factors for severe malaria included parasitemia and angiopoietin-2 in knowlesi malaria, and HRP2, angiopoietin-2, and microvascular dysfunction in falciparum malaria. Parasite biomass, endothelial activation, and microvascular dysfunction are associated with severe disease in knowlesi malaria and likely contribute to pathogenesis. The association of each of these processes with aging may account for the greater severity of malaria observed in older adults in low-endemic regions.

  9. The clinical presentation and therapy of diseases related to anti-neutrophil cytoplasmic antibodies (ANCA).

    Science.gov (United States)

    Weiner, Maria; Segelmark, Mårten

    2016-10-01

    Anti-neutrophil cytoplasmic antibodies (ANCA) are a family of autoantibodies that react with proteins predominantly expressed in cytoplasmic granules of polymorphonuclear neutrophil granulocytes (PMNs). ANCA was initially detected using indirect immunofluorescence, allowing for different patterns such as p-ANCA (perinuclear) and c-ANCA (cytoplasmic) to be distinguished. Today it is common to detect the antibodies by immunochemical assays such as ELISA using purified proteins as antigens. The strongest association with ANCA is found in the pauci-immune small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). There is compelling evidence that ANCA contributes to the pathogenesis in these conditions. ANCA also occurs in 30%-40% of patients with eosinophilic granulomatosis with polyangiitis (EGPA) and anti-GBM disease, but is uncommon in other forms of vasculitis. ANCA with different specificities have been described with varying frequencies in diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, inflammatory bowel disease, endocarditis, chronic infections and hematopoietic malignancies. ANCA can also develop as an adverse event during pharmacological treatment. These entities are treated quite differently, with therapies ranging from immunosuppressive agents over antibiotics to simply removing the causative drug. A positive ANCA test thus requires a careful diagnostic work-up.

  10. Pathogenesis of ANCA-associated vasculitis: An update.

    Science.gov (United States)

    Jarrot, Pierre-André; Kaplanski, Gilles

    2016-07-01

    Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes a group of rare diseases characterized by necrotizing inflammation of small blood vessels and the presence of ANCA. Although these autoantibodies were initially used to classify pauci-immune vasculitis, increasing clinical and experimental evidence now supports their pathogenic role, mainly through ANCA-induced activation of primed neutrophils and monocytes leading to destructive vascular necrosis. The mechanisms of ANCA generation remain however unclear. Neutrophils play a central role in the pathophysiological process of AAV since they are both effector cells responsible for endothelial damage and targets of autoimmunity. Another role of neutrophils is due to their ability to generate neutrophil extracellular traps, which support the presentation of ANCA autoantigens, could break immune tolerance and induce autoantibody generation. Alternatively, the ANCA autoimmune response is facilitated by insufficient T-cell and B-cell regulation, and the role of complement alternative pathway has recently been emphasized. This review summarizes the main pathogenesis concepts of AAV as well as the putative mechanisms for the origin of ANCA autoimmune response.

  11. Rifampicin-induced antineutrophil cytoplasmic antibody-positive vasculitis: a case report and review of the literature.

    Science.gov (United States)

    Ji, Guiyi; Zeng, Xuemei; Sandford, Andrew J; He, Jian-Qing

    2016-10-01

    Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a pauci-immune necrotizing vasculitis that involves small vessels. Herein, we report an extremely rare case of rifampicin (RFP)-induced AAV. A 42-yearold female was transferred to the West China Hospital due to cough with phlegm for 3 months, fever for 1 month, and fatigue for 2 weeks. The patient was diagnosed with pulmonary tuberculosis (TB) and received anti-TB treatment with isoniazid, RFP, ethambutol, and pyrazinamide (PZA) at her local hospital. After 5 days of anti-TB treatment, her creatinine level rose to 420.2 μmol/L from a normal level prior to anti-TB treatment. Serum proteinase 3 (PR3)-ANCA was positive. After discontinuing the anti-TB drugs and administering protective renal treatment, her renal function improved, whereas PR3-ANCA remained positive. With RFP rechallenge after transfer to our hospital, the patient developed oliguria. Her urine volume increased gradually after RFP was discontinued 3 days later. Therefore, RFPinduced AAV was suspected. Eventually, the patient received prednisone and anti-TB therapy, including isoniazid, ethambutol, PZA, and moxifloxacin. After 2 months, PZA was discontinued. During 6 months of normal, and PR3-ANCA became negative at 4 months. This outcome is characteristic of RFP-induced AAV.

  12. Systemic vasculitis associated with vemurafenib treatment: Case report and literature review.

    Science.gov (United States)

    Mirouse, Adrien; Savey, Léa; Domont, Fanny; Comarmond, Cloé; Barete, Stéphane; Plaisier, Emmanuelle; Rouvier, Philippe; Cacoub, Patrice; Saadoun, David

    2016-11-01

    Vemurafenib, an inhibitor of mutated B-rapidly accelerated fibrosarcoma, is frequently used in the treatment of melanoma and Erdheim-Chester disease (ECD) patients. Inflammatory adverse effects have been increasingly reported after vemurafenib treatment. We report 6 cases of vemurafenib-associated vasculitis, of whom a personal case of a 75-year-old man with history of ECD who developed purpura and rapidly progressive pauci-immune glomerulonephritis during treatment with vemurafenib. In the 5 others cases from the literature, all patients presented skin vasculitis, and with joint involvement in 60% of them. Vemurafenib treatment was stopped (n = 3), continued at reduced doses (n = 1), or continued at the same dose (n = 2). Three patients (50%) received corticosteroids combined with cyclophosphamide (n = 1), and all achieved remission of vasculitis. One patient experienced vasculitis relapse after vemurafenib therapy was restarted. Systemic vasculitis is a rare vemurafenib-associated adverse event that may be life-threatening.

  13. Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN.

    Science.gov (United States)

    Sethi, Sanjeev; Haas, Mark; Markowitz, Glen S; D'Agati, Vivette D; Rennke, Helmut G; Jennette, J Charles; Bajema, Ingeborg M; Alpers, Charles E; Chang, Anthony; Cornell, Lynn D; Cosio, Fernando G; Fogo, Agnes B; Glassock, Richard J; Hariharan, Sundaram; Kambham, Neeraja; Lager, Donna J; Leung, Nelson; Mengel, Michael; Nath, Karl A; Roberts, Ian S; Rovin, Brad H; Seshan, Surya V; Smith, Richard J H; Walker, Patrick D; Winearls, Christopher G; Appel, Gerald B; Alexander, Mariam P; Cattran, Daniel C; Casado, Carmen Avila; Cook, H Terence; De Vriese, An S; Radhakrishnan, Jai; Racusen, Lorraine C; Ronco, Pierre; Fervenza, Fernando C

    2016-05-01

    Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim of standardizing the kidney biopsy report of GN. On the basis of etiology/pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The pathogenesis-based classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.

  14. Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.

    Science.gov (United States)

    Harabuchi, Yasuaki; Kishibe, Kan; Tateyama, Kaori; Morita, Yuka; Yoshida, Naohiro; Kunimoto, Yasuomi; Matsui, Takamichi; Sakaguchi, Hiroshi; Okada, Masahiro; Watanabe, Takeshi; Inagaki, Akira; Kobayashi, Shigeto; Iino, Yukiko; Murakami, Shingo; Takahashi, Haruo; Tono, Tetsuya

    2017-01-01

    We aimed to analyze clinical features and treatment outcomes of otitis media caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), i.e. otitis media with AAV (OMAAV). This survey was performed between December 2013 and February 2014. The study began with a preliminary survey to 123 otolaryngology institutions in Japan to inquire about their experiences with OMAAV patients during the past 10 years, and was followed by a questionnaire survey to investigate clinical and laboratory findings. OMAAV was defined using the criteria described in the text. Two hundred and thirty-five patients classified as OMAAV were enrolled in this study. They were characterized as follows: (1) disease onset with initial signs/symptoms due to intractable otitis media with effusion or granulation, which did not respond to ordinary treatments such as antibiotics and insertion of tympanic ventilation tubes, followed by progressive hearing loss; (2) predominantly female (73%) and older (median age: 68 years); (3) predominantly myeloperoxidase (MPO)-ANCA-positive (60%), followed by proteinase 3 (PR3)-ANCA-positive (19%) and both ANCAs-negative (16%); (4) frequently observed accompanying facial palsy (36%) and hypertrophic pachymeningitis (28%); and (5) disease often involving lung (35%) and kidney (26%) lesions. Four factors associated with OMAAV were found to be related to an unfavorable clinical course threatening the patient's hearing and/or lives, namely facial palsy, hypertrophic pachymeningitis, both ANCAs-negative phenotype, and disease relapse. The occurrence of hypertrophic pachymeningitis was associated with facial palsy (p < 0.05), both ANCAs-negative phenotype (p < 0.001), and headache (p < 0.001). The administration of corticosteroid together with an immunosuppressant was an independent predicting factor for lack of disease relapse (odds ratio [OR] = 1.90, p = 0.03) and an improvement in hearing loss (OR =2.58, p = 0.0002). Since

  15. GETDB: 112404 [GETDB

    Lifescience Database Archive (English)

    Full Text Available e 510 1 Request - muscle - sg, fb, tr, tarsus crescent - - - comment1:A, comment2...sg, fb, tr, tarsus crescent Adult GFP - Lethality - Also known as - Original Comments comment1:A, comment2:2

  16. Churg-Strauss syndrome

    Directory of Open Access Journals (Sweden)

    Ilić Tatjana

    2002-01-01

    Full Text Available Churg-Strauss syndrome (CSS is medium blood vessels vasculitis with predilection for lungs in patients with bronchial asthma, chronic eosinophilic pneumonia and positive ANCA in the sera in 55-67%. This is a case report of a 60 years old female patient with bronchial asthma, peripheral pulmonary infiltrations, blood eosinophilia, xerophtalmia, tachycardia, chronic rhino sinusitis, polyneuropathia and negative immunological tests: CIC (PEG, CRYO, ANA (IIF, RF (agglutination and ANCA (IIF: pANCA and cANCA; ELISA: proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G. Eosinophilic infiltrates in the tissues tested by skin and salivary gland biopsies were not found. The patient had fulfilled five clinical diagnostic criteria and responded well to immunosuppressive therapy, so this case could be classified as the ANCA negative angiitis and granulomatous of CSS type.

  17. Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA).

    Science.gov (United States)

    Abdulahad, Wayel H; Lepse, Nikola; Stegeman, Coen A; Huitema, Minke G; Doornbos-van der Meer, Berber; Tadema, Henko; Rutgers, Abraham; Limburg, Pieter C; Kallenberg, Cees G M; Heeringa, Peter

    2013-01-01

    The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). Peripheral blood from 42 GPA patients in remission and 29 age-matched healthy controls (HCs) were stimulated in vitro, and the frequencies of IL-21 producing Th-cells were determined by flow cytometry. Since Th17-cells produce a low level of IL-21, IL-17 was also included in the analysis. Given that IL-21 is a hallmark cytokine for T follicular helper cells (T(FH)), we next evaluated the expression of their key transcription factor BCL-6 by RT-PCR and flow cytometry. To investigate the effect of IL-21 on autoantibody-production, PBMCs from GPA patients were stimulated in vitro with BAFF/IL-21 and total IgG and ANCA levels were measured in supernatants. In addition, the expression of IL-21-receptor on B-cells was analyzed. Percentages of IL-21 producing Th-cells were significantly elevated in GPA-patients compared to HCs, and were restricted to ANCA-positive patients. The expression of BCL-6 was significantly higher in ANCA-positive GPA-patients, as compared with ANCA-negative patients and HCs. IL-21 enhanced the production of IgG and ANCA in vitro in stimulated PBMCs from GPA patients. No difference was found in the expression of the IL-21-receptor on B-cells between ANCA-negative patients, ANCA-positive patients, and HCs. The increased frequency of circulating IL-21 producing Th-cells in ANCA-positive GPA patients and the stimulating capacity of IL-21 on ANCA-production suggest a role for these cells in the immunopathogenesis of GPA. Blockade of IL-21 could constitute a new therapeutic strategy for GPA.

  18. 75 FR 54177 - Notice of Availability of Draft Environmental Impact Statement for the Tonopah Solar Energy...

    Science.gov (United States)

    2010-09-03

    ... Environmental Impact Statement for the Tonopah Solar Energy Crescent Dunes Solar Energy Project, Nye County, NV...) has prepared a Draft Environmental Impact Statement (EIS) for the Crescent Dunes Solar Energy Project... news releases, and/or mailings. ADDRESSES: You may submit comments on the Crescent Dunes Solar...

  19. Oscillatory infragravity wave contribution to surf zone sediment transport

    DEFF Research Database (Denmark)

    Aagaard, Troels; Greenwood, Brian

    2008-01-01

    can create a perturbation of the bar crest and/or generate a crescentic bar. These results provide support for the template model for crescentic bar formation, first proposed by Bowen and Inman (Bowen, A.J. and Inman, D.L., 1971. Edge waves and crescentic bars. J.Geophys.Res., 76, 8662-8670) although...

  20. Tubular overexpression of gremlin induces renal damage susceptibility in mice.

    Directory of Open Access Journals (Sweden)

    Alejandra Droguett

    Full Text Available A growing number of patients are recognized worldwide to have chronic kidney disease. Glomerular and interstitial fibrosis are hallmarks of renal progression. However, fibrosis of the kidney remains an unresolved challenge, and its molecular mechanisms are still not fully understood. Gremlin is an embryogenic gene that has been shown to play a key role in nephrogenesis, and its expression is generally low in the normal adult kidney. However, gremlin expression is elevated in many human renal diseases, including diabetic nephropathy, pauci-immune glomerulonephritis and chronic allograft nephropathy. Several studies have proposed that gremlin may be involved in renal damage by acting as a downstream mediator of TGF-β. To examine the in vivo role of gremlin in kidney pathophysiology, we generated seven viable transgenic mouse lines expressing human gremlin (GREM1 specifically in renal proximal tubular epithelial cells under the control of an androgen-regulated promoter. These lines demonstrated 1.2- to 200-fold increased GREM1 expression. GREM1 transgenic mice presented a normal phenotype and were without proteinuria and renal function involvement. In response to the acute renal damage cause by folic acid nephrotoxicity, tubule-specific GREM1 transgenic mice developed increased proteinuria after 7 and 14 days compared with wild-type treated mice. At 14 days tubular lesions, such as dilatation, epithelium flattening and hyaline casts, with interstitial cell infiltration and mild fibrosis were significantly more prominent in transgenic mice than wild-type mice. Tubular GREM1 overexpression was correlated with the renal upregulation of profibrotic factors, such as TGF-β and αSMA, and with increased numbers of monocytes/macrophages and lymphocytes compared to wild-type mice. Taken together, our results suggest that GREM1-overexpressing mice have an increased susceptibility to renal damage, supporting the involvement of gremlin in renal damage

  1. Fatigue,hypopotassemia, anemia and renal function%乏力,低钾,贫血伴肾功能不全

    Institute of Scientific and Technical Information of China (English)

    全军肾脏病研究所学术委员会

    2011-01-01

    A 49-year female was presented with fatigue, hypopotassemia, anemia, and renal dysfunction for half a year. The laboratary investigation showed tubulointerstitial injury without proteinuria and hemoturia. Serum pANCA and Elastase ANCA were positive. The renal histological examination demonstrated tubulointerstitial nephritis with peritubular capillaritis, tubulitis and some obsolescent, but otherwise near normal glomeruli. Immunoflurescence study indicated pauci-immune deposits. After immunosuppressive treatment, serum ANCA turned negative and renal function was remarkably improved. Repeat biopsy showed that the interstitial inflammation was significantly ameliorated. Finally, ANCA associated tubulointerstitial nephritis was diagnosed.%49岁女性,以乏力、低钾起病,近半年出现贫血,肾功能不全,无血尿,蛋白尿,无咯血等肺部表现,肾小管间质损害明显,血清核周型抗中性粒细胞胞质抗体(pANCA)阳性,弹性蛋白酶ANCA阳性.肾活检组织学表现为间质性肾炎,可见大量管周毛细血管炎,肾小管炎,伴肾小球废弃,非废弃肾小球病变轻微,免疫病理示寡免疫复合物沉积.甲泼尼龙和环磷酰胺冲击治疗后,血清ANCA转阴,随之肾功能改善,重复肾活检肾小管间质急性病变也明显减轻.结合临床、实验室检查,对免疫抑制治疗反应及两次肾活检组织学特点,最终诊断为ANCA相关性间质肾炎.

  2. Impact of immunofluorescence on the histological pattern of pediatric kidney biopsies from northern Pakistan.

    Science.gov (United States)

    Ali, Akhtar; Ali, Mohammad Usman; Ali, Mahrukh Ayesha

    2011-01-01

    Kidney biopsy is an investigation for diagnosis and prognosis of a variety of nephritides. It also influences therapeutic options. Immunofluorescence (IMF) greatly adds in identifying the pathologies which may not be obvious on light microscopy (L/M), such as IgM, IgA nephropathy, pauci-immune glomerulonephritis, and anti-glomerular basement membrane disease. We present here data of 170 pediatric kidney biopsies from July 2005 to December 2009 from Department of Nephrology and Hypertension, Lady Reading Hospital, Peshawar, Pakistan. The study was undertaken to see whether IMF would alter the histological pattern of pediatric kidney biopsies and to compare these data with an earlier data from our department of 415 pediatric kidney biopsies done over 7-year period from 1998 to 2005, which were analyzed with L/M alone. Out of 170 kidney biopsies using L/M and IMF, IgM turns out to be most common pattern (20%), followed by minimal change disease (MCD) (17.05%), focal and segmental glomerulosclerosis (FSGS) (15.88%), chronic sclerosing glomerulonephritis (Chr. sclerosing GN) (12.35%), mesangio proliferative glomerulonephritis (MPGN) (7.65%), mesangio capillary glomerulonephritis (MCGN) (6.47%), membranous glomerulonephritis (Mem. GN) (5.29%), IgA nephropathy (5.29%), cresentic glomerulonephritis (Cres. GN) (3.53%), lupus nephritis (2.96%), and others (3.53%). Comparing these results of 170 cases with 415 renal biopsies without IMF, IgM dominated the histological pattern in IMF group whereas MCD followed by FSGS and MPGN were prominent in group without IMF. Therefore, variation in the overall histological pattern with IMF technique proved statistically significant (p < 0.0001). Addition of IMF has altered the frequency of MCD, a change from 24% (100/415) to 17% (29/170), FSGS from 18.3% (76/415) to 15.88% (27/170), and MPGN from 17.35% (72/415) to 7.65% (13/170).

  3. De novo glomerular diseases after renal transplantation.

    Science.gov (United States)

    Ponticelli, Claudio; Moroni, Gabriella; Glassock, Richard J

    2014-08-07

    Glomerular diseases developing in the kidney allograft are more often recurrences of the original disease affecting the native kidneys. However, in an undefined number of cases de novo, glomerular diseases unrelated to the original disease in the native kidneys can develop in the transplanted kidney. The clinical presentation and histologic features of de novo diseases are often similar to those features observed in patients with primary or secondary GN in the native kidneys. However, in transplanted kidneys, the glomerular, vascular, and tubulointerstitial changes are often intertwined with structural abnormalities already present at the time of transplant or caused by antibody- or cell-mediated allograft rejection, immunosuppressive drugs, or superimposed infection (most often of a viral nature). The pathophysiology of de novo glomerular diseases is quite variable. In rare cases of de novo minimal change disease, circulating factors increasing the glomerular permeability likely participate. Maladaptive hemodynamic changes and tissue fibrosis caused by calcineurin inhibitors or other factors may be involved in the pathogenesis of de novo FSGS. The exposure of cryptic podocyte antigens may favor the development of de novo membranous nephropathy. Many cases of de novo membranoproliferative GN are related to hepatitis C virus infection. Patients with Alport syndrome lacking antigenic epitopes in their glomerular basement membrane may develop antibodies against these glomerular basement membrane antigens expressed in the transplanted kidney. Infection may cause acute GN to have a heterogeneous clinical presentation and outcome. De novo pauci-immune GN in renal transplant is rare. Preexisting or acquired intolerance to glucose may, in the long term, cause diabetic nephropathy. The prognosis of de novo diseases depends on the type of GN, the severity of lesions caused by the alloimmune response, or the efficacy of immunosuppressive therapy. In most cases, the management

  4. RU’YAT AL-HILĀL DENGAN TEKNOLOGI : Telaah Pelaksanaan Ru’yat al-Hilāl di Baitul Hilal Teluk Kemang Malaysia

    Directory of Open Access Journals (Sweden)

    Dito Alif Pratama

    2016-10-01

    Full Text Available Baitul Hilal Teluk Kemang which is located at coordinate latitude 2 ° 26 '44' in the North and longitude 101° 51'21' in the East, is one of the good record crescent sighting observation center in Malaysia. The result of the study is as follows, firstly, the method of crescent observation at Baitul Hilal seems quite effective since it is located in a strategic and suitable place for crescent observation activity. Baitul Hilal is also supported by some sophisticated technology such as telescope and DSLR camera operated by some crescent observers who are officially certified by the Malaysian government. Secondly, Baitul Hilal has contributed to crescent observation development in Malaysia. Baitul Hilal also provides with the astronomical data based on monthly crescent activity as an additional data for crescent researcher to analyze the imkᾱn al-rukyah criterion.

  5. Desempenho e características da carcaça de tourinhos Santa Gertrudes confinados, recebendo dietas com alto concentrado e níveis crescentes de polpa cítrica peletizada Feedlot performance and carcass characteristics of Santa Gertrudis bulls, fed high concentrate diets with increasing levels of dehydrated citrus pulp pellets

    Directory of Open Access Journals (Sweden)

    Wignez Henrique

    2004-04-01

    Full Text Available O experimento foi desenvolvido com o objetivo de avaliar o efeito da substituição do milho pela polpa cítrica peletizada sobre o desempenho e as características da carcaça de tourinhos Santa Gertrudes confinados. Vinte e oito animais, com nove meses de idade e peso inicial de 277 kg, foram confinados em baias individuais. O período experimental foi de 92 dias, após 21 dias de adaptação. Os animais receberam dietas contendo 20% da matéria seca como silagem de milho, com 40% de grãos. Foram testados os níveis de 0, 25, 40 e 55% de participação da polpa cítrica peletizada na matéria seca da dieta. Não houve efeito do nível de polpa cítrica na dieta sobre ganho de peso, ingestão diária de matéria seca, eficiência alimentar, rendimento de carcaça, área de olho de lombo e peso da gordura renal-pélvica-inguinal. Os pesos do fígado e da carcaça foram significativamente maiores com o aumento da polpa cítrica na dieta, que também determinou decréscimo linear na espessura de gordura sobre a 12ª costela. O pH das fezes foi semelhante entre os níveis de participação da polpa cítrica. Não foi verificada a ocorrência de abscessos no fígado em nenhum tratamento, apesar da dieta conter alto teor de concentrado. A polpa cítrica peletizada pode compor até 55% da matéria seca de dietas, substituindo o milho em grão, para tourinhos em terminação recebendo altos níveis de concentrado, apenas com diminuição da espessura de gordura.The experiment was developed to evaluate the effect of the replacement of corn grain by dehydrated citrus pulp pellets on the performance and carcass characteristics of Santa Gertrudis young bulls fed high concentrate diets. Twenty-eight bulls, with average age of nine months and an initial weight of 277 kg, were kept in individual pens and fed during 92 days, after 21 days of adaptation. The animals were fed a diet with 20% of the dry matter as corn silage, with 40% of grain. Treatments evaluated included levels of 0, 25, 40 and 55% of dehydrated citrus pulp pellets in the dry matter diet. There was no effect of citrus pulp level on the average daily gain, daily dry matter intake, feed efficiency, carcass dressing, Longissimus muscle area and the kidney, pelvic and inguinal fat. The increasing level of citrus pulp on the diet decreased linearly the backfat thickness and increased linearly the liver weight and carcass weight. The feces pH was similar for all the citrus pulp levels. Liver abscess were not detected, although the diet had high concentrate level. The dehydrated citrus pulp pellets can compound until 55% of dry matter diet, replacing corn grain to finishing young bulls fed high concentrate diets, with a small decrease in subcutaneous fat.

  6. Efeito de déficit hídrico transiente e doses crescentes de boro sobre a fertilidade de gemas de videira cv. Itália Effects of transient water stress and increasing doses of boron on the bud fertility in grapevines cv. Itália

    Directory of Open Access Journals (Sweden)

    Jorbas Sampaio de Melo

    2011-06-01

    Full Text Available O objetivo deste trabalho foi verificar o efeito de diferentes tensões de água no solo e diferentes concentrações de boro, na fertilidade de gemas de videira cv. Itália, manejada sob o sistema de poda mista. O experimento foi conduzido em pomar comercial, no município de Petrolina-PE. O delineamento experimental utilizado foi o de blocos ao acaso, em esquema fatorial 3x3: três tensões indicativas para a recarga hídrica por irrigação (-30 kPa, -50 kPa e -70 kPa e três concentrações de boro (3%, 6% e 9%, com três repetições e duas plantas por parcela. A testemunha não recebeu aplicações com boro e o solo foi mantido com umidade na capacidade de campo (-10 kPa. As variáveis analisadas foram fertilidade de gemas, índice relativo de clorofila (IRC e área foliar. Os dados foram interpretados por meio de análise de variância e regressão, e os modelos escolhidos com base na significância do coeficiente de regressão (R² > 0,70. Verificou-se que a fertilidade de gemas mostrou efeito linear negativo em função do aumento da tensão de água no solo, diminuindo de 31,88% (-30 kPa, para 23,66% (-70 kPa. Contudo, a fertilidade de gemas nas videiras submetidas a uma restrição hídrica de -30 kPa foi superior à tensão de -10 kPa; o boro a 3% propiciou a maior taxa de fertilidade de gemas em comparação aos demais tratamentos com boro; a restrição hídrica no solo a -30 kPa ocasionou economia no volume de água aplicada da ordem de 35,4% em comparação ao manejo com -10 kPa; o índice relativo de clorofila aumentou linearmente com o acréscimo das tensões de água no solo e houve maior expansão da área foliar em plantas submetidas ao manejo da irrigação na capacidade de campo.The present paper had the purpose to ascertain the effects of different soil water tensions and different concentrations of boron on the bud fertility in grapevines cv. Italia, grown under a mixed system of pruning. The experiment was conducted in a commercial vineyard in the municipality of Petrolina, state of Pernambuco, Brazil. The experimental set-up was a randomized block design, in a factorial scheme 3x3: three indicative tensions for water recharge by irrigation (-30 kPa, -50 kPa and -70 kPa and three boron concentrations (3%, 6% and 9%, with three replications and two plants per plot. The control did not receive boron applications and the soil moisture was maintained at field capacity (-10 kPa. The analyzed variables were bud fertility, relative chlorophyll index (CRI, and leaf area. The data were interpreted by means of analyses of variance and regression, and the models were chosen based on the significance of the regression coefficient (R²> 0.70. It was observed that the bud fertility showed a negative linear effect in keeping with the increase of soil water tension, decreasing from 31.88% (-30 kPa to 23.66% (-70 kPa. However, the bud fertility of grapevines submitted to a water stress of -30 kPa was superior to the one at -10 kPa; boron at 3% resulted in the highest bud fertility rate when compared to the other treatments with boron; soil water stress at -30 kPa caused an economy in applied water of 35.4% when compared to the management at -10 kPa; the relative chlorophyll index increased linearly to the increase of soil water tension, and there was a greater expansion in the leaf area in plants submitted to irrigation management at field capacity.

  7. Scintillography study of the gallbladder filling and her emptying under stimulation with growing doses of caerulein in the digestive form of Chagas` disease; Estudo cintilografico do enchimento da vesicula biliar e do seu esvaziamento sob estimulo com doses crescentes de ceruleina na forma digestiva da molestia de Chagas

    Energy Technology Data Exchange (ETDEWEB)

    Villanova, Marcia Guimaraes

    1988-12-31

    Chagas` disease patients with mega esophagus and/or mega colon (n=16), as well as control subjects (n=10) underwent a cholescintigraphic study following the intravenous injection of 3.0 mCi of {sup 99m}Tc -DISIDA, in order to quantitate accurately dynamic events associated to gallbladder filling and emptying. Gallbladder filling was evaluated for 90 min after the injection of the radionuclide, by comparing the activity on the region of interest corresponding to gallbladder to hose on regions corresponding to the liver and the gastrointestinal tract. Gallbladder emptying was studied in response to the continuous intravenous infusion of caerulein (CRL) in four 15 min periods corresponding to increasing doses of respectively 7,5 15,0 30,0 and 60,0 ng. Kg{sup -1}. h{sup -1}. In another test the CRL infusion was associated to the infusion of atropine at a low dose (5,0 {mu}g. kg. kg{sup -1}.h{sup -1}). Gallbladder emptying was also studied following an intravenous bolus injection of CRL (60 ng. kg{sup -1}). (author). 103 refs., 25 figs.

  8. CHEMICAL AND FERMENTATIVE CHARACTERISTICS OF ELEPHANT GRASS ENSILED WITH INCREAS-ING LEVELS OF DENIDRATED CASHEW FRUIT BY-PRODUCT CARACTERÍSTICAS QUÍMICAS E FERMENTATIVAS DO CAPIM-ELEFANTE ENSILADO COM NÍVEIS CRESCENTES DE SUBPRODUTO DA AGROINDÚSTRIA DO CAJU

    Directory of Open Access Journals (Sweden)

    Warley Efrem Campos

    2007-12-01

    Full Text Available

    Nutritive value of silages of Elephant grass (Pen-nisetum   purpureum, Schum. mixed with 0; 3.5%; 7.0%; 10.5% and 14.0 %  of dehydrated by product from juice industry of cashew fruit (Anacardium occidentale, L (DBC was determined. A randomized design was used with four replicates. Silages were opened after 65 days and samples taken for analysis of dry matter (DM, crude protein (CP, neutral detergent fiber (NDF, acid detergent fiber (ADF, hemicellulose HCEL, cellulose (CEL, lig-nin (LIG, crude energy (CE, ash, neutral detergent inso-luble nitrogen (NDIN and acid detergent insoluble nitro-gen (ADIN. Were also analyzed, pH, ammonia nitrogen and organic acids (lactic, acetic, butyric and propionic. Regarding fermentative parameters, there was an expected decrease in pH and the increasing levels of DBC did not affect the concentrations of N-NH3/NT and organic acids. It is concluded that dehydrated cashew by product can be ensiled along with Elephant grass without altering its fer-mentative characteristics. On the other side, the increased cell walls and ADIN contents of the silage may affect its nutritional value.

    Key-words: Cashew byproducts, nutritive value, tropical grass.

    O trabalho foi desenvolvido com o objetivo de se avaliar o valor nutritivo das silagens de capim-elefante (Pennisetum purpureum, Schum. com adição de 0%; 3,5%; 7%; 10,% e 14% do subproduto do pseudofruto do caju (Anacardium occidentale, L. desidratado (subproduto da agroindústria do suco de caju. Utilizou-se o delineamento inteiramente casualizado, com quatro repetições. Após 65 dias, os silos foram abertos e coletadas amostras para determinação dos teores de matéria seca (MS, proteína bruta (PB, fibra em detergente neutro (FDN, fibra em detergente ácido (FDA, hemicelulose (HCEL, celulose (CEL, lignina (LIG, energia bruta (EB, cinzas, nitrogênio insolúvel em detergente neutro (NIDN e nitrogênio insolúvel em detergente ácido (NIDA. Para avaliar as características fermentativas das silagens, determinaram-se os valores de pH e os teores de nitrogênio amoniacal (% do nitrogênio total e dos ácidos lático, acético, butírico e propiônico. A adição do subproduto do pseudofruto do caju desidratado (SPCD acarretou o aumento dos teores de MS, PB, FDA, LIG, NIDN e NIDA. Para os parâmetros fermentativos, observou-se redução dos valores de pH, porém não se registrou influência dos níveis de adição do SPCD sobre os teores de N-NH3/NT e ácidos orgânicos. Conclui-se que o subproduto do pseudofruto do caju desidratado pode ser ensilado com o capim-elefante, sem comprometer as características fermentativas das silagens de capim-elefante. Porém, o aumento nos componentes da parede celular e do NIDA pode comprometer o valor nutri-cional do ensilado final.

    Palavras-chaves: Gramínea tropical, subprodutos do caju, valor nutritivo.

  9. Crescimento vegetativo e produção de cafeeiros (Coffea arabica L. recepados em duas épocas, conduzidos em espaçamentos crescentes Vegetative growth and yield of coffee plants (Coffea arabica L. in two different pruning times, conducted at different spacings

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    Sérgio Parreiras Pereira

    2007-06-01

    Full Text Available O experimento foi instalado na Fazenda Experimental da Empresa de Pesquisa Agropecuária de Minas Gerais - EPAMIG em Machado, Sul de Minas Gerais, em 1992, com o objetivo de avaliar as conseqüências da redução dos espaçamentos entre as linhas e entre as plantas na linha de plantio sobre a produção e a fenologia do cafeeiro(Coffea arabica L.. O delineamento experimental foi o blocos casualizados - DBC, em um arranjo fatorial 4 x 3 com parcela subdividida, sendo quatro distâncias entre as linhas (2,0; 2,5; 3,0 e 3,5 m e três distâncias entre as plantas na linha de plantio (0,5; 0,75; 1,0 m, e duas épocas de poda (uma precoce feita logo após a colheita em de julho 2002 e a outra tardia em de janeiro de 2003, totalizando 24 tratamentos com três repetições. Em julho de 2002 e em janeiro de 2003 foi realizada a poda tipo "recepa", na qual foram conduzidas duas brotações por planta. Em agosto de 2004, avaliou-se o crescimento dos componentes vegetativos e a produção das parcelas. Os espaçamentos adotados não influenciaram o crescimento de nenhum dos componentes vegetativos das brotações no período avaliado. Todas as características vegetativas foram influenciadas positivamente pela adoção da poda precoce, assim como a produtividade da primeira colheita realizada após a poda, que foi também influenciada positivamente pela adoção de espaçamentos mais adensados. Os cafeeiros que foram submetidos à poda tardia não produziram, em julho de 2004, como aqueles podados precocemente.The experiment was established in the Empresa de Pesquisa Agropecuária de Minas Gerais - Epamig Experiment Station, located in the city of Machado, south of the Minas Gerais state, Brazil, in the year of 1992, with the objective of evaluating the consequences of the reduction on planting spaces among rows and among plants, upon beans yield and plant phenology (Coffea arabica L.. The experimental design used was a 4x 3 factorial with split plot at four distances between planting rows (2,0; 2,5; 3,0 e 3,5 m and three distances among plants in the row (0,5; 0,75 e 1,0 m, and two different pruning times (one precociously conducted just after the harvest, on july 2002, and the other latter on january 2003, making a total 24 treatments arranged in randomized blocks with three replicates. In july 2002 and january 2003 a drastic pruning was clone and conducing two sprouts per plant. Vegetative growth and beans yield were evaluated in august 2004. Coffee plant spacing did not affected growth of any of the vegetative components of sprouting, during the evaluated period. All the vegetative characteristics were positively affected by the early pruning procedure, as well as the beans yield of the first harvest after pruning, which also showed to be positively influenced by the adoption of a narrower spacing plant. The coffee plants which were submitted to late prunning, had lancer bean yield in july 2004 as those precociously prunned.

  10. A crescente preocupação com questão distributiva no pensamento de Adam Smith - doi: 10.4025/dialogos.v9i2.154 Increasing concern on the distributive problem in Adam Smith - doi: 10.4025/dialogos.v9i2.154

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    Rodrigo Gandra

    2010-05-01

    Full Text Available Este paper tenta elucidar alguns tópicos sobre a evolução do pensamento de Adam Smith sobre a desigualdade, desde a Teoria dos Sentimentos Morais até a Riqueza das Nações. Ele também discute o conceito de justiça social bem como sua conexão com a desigualdade e ordem social.This paper tries to highlight some topics about the evolution of Adam Smith’s thought about inequality, since Theory of Moral Sentiments, until the Wealth of Nations. It also discusses the mean of social justice as well its connection with inequality and social order.

  11. A crescente escolarização do agente comunitário de saúde: uma indução do processo de trabalho? The increasing schooling of the community health agent: an induction of the work process?

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    Roberta Rodrigues de Alencar Mota

    2010-10-01

    Full Text Available O agente comunitário de saúde (ACS é um dos atores profissionais que compõem as equipes da Estratégia Saúde da Família (ESF, sendo sua atuação considerada fundamental para a ampliação e consolidação dessa estratégia. Desde as primeiras experiências locais com ACS em fins dos anos 1970, seu perfil sociodemográfico vem apresentando mudanças. Este artigo tem por objetivo apresentar e discutir o aspecto da escolaridade e da capacitação dos ACS que atuam na Área Programática (AP 5.2 do município do Rio de Janeiro, articulando trabalho e educação e entendendo o trabalho como um princípio emancipatório. Este estudo foi formulado com base na ideia de triangulação metodológica, aqui alcançada a partir da formulação original de Denzin. Os dados sobre a escolaridade dos ACS foram obtidos mediante questionário autoaplicável individual, respondidos por 301 ACS dos 12 módulos de ESF e seis módulos da Estratégia de Agentes Comunitários de Saúde (EACS da AP 5.2. A apresentação e a discussão dos dados mostram mudanças no perfil de escolaridade desse trabalhador, concluindo-se que o ACS é um trabalhador que busca alternativas de escolarização e formação profissional. Defende-se a ampliação da escolaridade e o ensino técnico como processo para a consolidação do Sistema Único de Saúde.Community health agents (CHA are among the professional players that make up the Family Health Strategy (FHS teams, and their performance is considered as critical to the expansion and consolidation of this strategy. Since the first local experiences with CHAs in the late 1970s, their sociodemographic profile has been changing. This article aims to present and discuss the aspect of education and training of the CHAs who work in Program Area (PA 5.2 of the city of Rio de Janeiro, integrating work and education and understanding the work as an emancipatory principle. This study was formulated based on the methodological triangulation idea, reached here based on the original formulation of Denzin. Data on the CHAs' education were obtained via an individual self-applied questionnaire answered by 301 of the CHAs of the 12 FHS modules and six Community Health Workers Strategy (CHWS modules of PA 5.2. The presentation and discussion of the data show changes in this worker's educational profile, and it can be concluded that the CHA is a worker who is in search of alternative schooling and vocational training. An expansion of the schooling and technical education is defended as a process to consolidate the Unified Health System.

  12. Híbridos de sorgo (Sorghum bicolor (L. Moench cultivados sob níveis crescentes de adubação: características agronômicas, carboidratos solúveis e estruturais da planta Sorghum (Sorghum bicolor (L. Moench hybrids cultivated under increasing fertilization levels: agronomic characteristics, soluble and structural carbohydrates of the plant

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    Miguel Marques Gontijo Neto

    2004-12-01

    Full Text Available Foram avaliadas características agronômicas, fibra em detergente neutro (FDN, fibra em detergente ácido (FDA e carboidratos solúveis e estruturais de cinco híbridos de sorgo forrageiro (AG-2002, AG-2005E, AGX-202, AGX-213 e AGX-215, cultivados sob quatro níveis de adubação NPK. Utilizou-se o delineamento em blocos casualizados, em esquema fatorial 5 x 4, com quatro repetições. As médias dos fatores qualitativos foram comparadas pelo teste de Tukey a 5 e 1% de probabilidade. Os híbridos avaliados apresentaram diferentes proporções de colmos (29,01 a 53,38%, de folhas (16,70 a 22,64% e de panículas (29,91 a 52,43%, sendo colmos e panículas fortemente correlacionadas com altura, 0,79** e -0,82**, respectivamente. O teor de matéria seca (MS da planta inteira foi fortemente influenciado pelas proporções de colmos e panículas, tendo as panículas apresentado os maiores teores de MS (48,79 a 56,80% e colmos as menores (18,86 a 22,54%. O aumento nos níveis de adubação proporcionou acréscimo na produção de panículas, que refletiu na diminuição da relação colmo + folha/panícula, no acréscimo da proporção de panículas e no teor de MS da planta inteira. Os teores de carboidratos solúveis totais, com base na matéria seca, variaram entre os híbridos avaliados (12,24 a 19,80% e apresentaram aumento com a elevação dos níveis de adubação. Os híbridos avaliados apresentaram diferenças significativas entre os teores de fibra em detergente neutro (57,38 a 62,30%, fibra em detergente ácido (25,29 a 31,56%, hemicelulose (28,56 a 33,87%, celulose (19,20 a 24,34% e lignina (6,04 a 6,51%. O avanço nos níveis de adubação resultou em queda nos teores de FDN e hemicelulose.The agronomic characteristics, neutral detergent fiber (NDF, acid detergent fiber (ADF and total soluble and structural carbohydrates contents of five hybrid sorghum (AG-2002, AG-2005E, AGX-212, AGX-213 e AGX-215, cultivated under different fertilization levels, were evaluated. A randomized blocks design, in a 5 x 4 factorial scheme, with four replicates, was used. The qualitative factors means were analyzed by means of Tukey test at 5 and 1% of probability. The evaluated hybrids showed different proportions of stem (29.01 to 53.38%, leaves (16.70 to 22.64% and panicle (29.91 to 52.43%, where stem and panicle were highly correlated with height, 0.79** and -0,82**, respectively. Dry matter content of whole plant was strongly affected by stem and panicle proportion, where the panicle showed higher DM contents (48.79 to 56,80% and stem, the smaller (18.86 to 22.54%. The increase in the fertilization levels provided increment in the panicle production, that decreased stem+leaves/panicle proportions and increased panicle proportion and DM content of whole plant. The total soluble carbohydrates contents, in dry matter basis, varied among evaluated hybrids (12.24 to 19.80% and increased as the fertilization levels increased. The evaluated hybrids showed significant differences among the NDF (57.38 to 62.30, ADF (25.29 to 31.56%, hemicellulose (28.56 to 33.87%, cellulose (19.20 to 24.34% and lignin (6.04 a 6.51% contents. The NDF and hemicellulose contents decreased as the fertilization levels increased.

  13. Níveis crescentes de suplementação energética sobre o desenvolvimento de novilhos mantidos em pastagem natural na encosta do sudeste do Rio Grande do Sul Increasing levels of energy supplementation on development of grazing steers kept on a natural pasture at the southeastern region of Rio Grande do Sul

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    René Mauricio Patiño Pardo

    2003-12-01

    Full Text Available O experimento foi desenvolvido de 11 de agosto a 15 de novembro de 2000, com a finalidade de avaliar os efeitos de suplementação energética com sorgo moído sobre o desempenho de novilhos de corte em pastejo. Foram utilizados 38 novilhos de 12 a 15 meses de idade, sem raça definida, com 159,97 kg. Os animais foram mantidos em pastejo contínuo, em uma pastagem natural melhorada com Lotus subbiflorus e invadida por Eragrostis planna, Ness. Os tratamentos consistiram de controle (T0, sem suplemento; 0,75% do peso vivo (T0.75 e 1,5% do peso vivo (T1.5 de grão de sorgo moído. Os animais foram distribuídos aleatoriamente aos tratamentos, segundo delineamento completamente casualizado. Os efeitos da suplementação sobre o ganho de peso médio diário (GMD e o incremento de escore de condição corporal (IECC foram observados no primeiro período, de 11 de agosto a 6 de setembro, e na média geral do experimento, quando foram observadas respostas quadráticas do GMD e IECC aos níveis de suplemento. Não foi observado efeito dos níveis de suplemento sobre o ganho de altura de cernelha e perímetro torácico. A suplementação energética permitiu maiores ganho de peso e incremento de escore de condição corporal nos animais suplementados em relação aos animais controle no período final de inverno, mas não apresentou efeito na primavera.The trial was conducted from August 11th to November 15th, to evaluate the effects of energetic supplementation with ground sorghum grain on grazing beef steers performance. Thirty eight steers without definite breed, aging 12 to 15 months and weighing 159,97 kg were used. Animals were kept under set stocking on a natural pasture improved with Lotus subbiflorus and invaded with Eragrostis planna, Ness. Treatments consisted of control or without supplement (T0; 0.75% of mean live weight (T0.75 and 1.5% of mean live weight (T1.75 of ground sorghum grain. Animals were randomly assigned to treatments according to a complete randomized design. The effects of treatments on animals live weight daily gain (ADG and increment of body condition score (IBCS were just observed at the first period, from August 11th to September 6th, and considering the overall mean of the experiment, when a quadratic response was observed. There were no supplementation effects upon increment of height at withers and hearth girth. Supplementation with ground sorghum grain increased ADG and IBCS compared to no supplemented animals at the end of the winter, however, there was no effect during spring.

  14. Digestibilidade e balanço de nitrogênio em ovinos alimentados à base de dietas com elevado teor de concentrado e níveis crescentes de polpa cítrica peletizada Digestibility and nitrogen balance by sheep fed high concentrate diets with increasing levels of dried citrus pulp pellets

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    Wignez Henrique

    2003-12-01

    Full Text Available O experimento foi realizado com o objetivo de determinar os coeficientes de digestibilidade, a ingestão de nutrientes e o balanço de nitrogênio de dietas com 20% de silagem de milho e 80% de concentrado e 0, 25, 40 e 55% de polpa cítrica na matéria seca total, substituindo o milho em grão. Em delineamento de blocos ao acaso, foram utilizados oito cordeiros mestiços, com nove meses de idade e 34 kg de peso, mantidos em gaiolas individuais com dispositivo para separação de fezes e urina. O período de coleta de alimento, sobras, fezes e urina foi de seis dias e a quantidade de alimento oferecido correspondeu à média do consumido nos três últimos dias do período de adaptação. O experimento foi desenvolvido em duas fases, utilizando-se os mesmos animais, que foram distribuídos em blocos pelo peso. Os resultados foram analisados por regressão polinomial. Houve aumento linear nos coeficientes de digestibilidade aparente da proteína bruta e da fibra em detergente ácido, com o aumento da participação da polpa cítrica na dieta. Os demais coeficientes de digestibilidade não diferiram entre si e foram, respectivamente: 71,8; 73,3; 77,2; 63,5; e 72,2%; para matéria seca, matéria orgânica, extrato etéreo, fibra em detergente neutro e hemicelulose. O teor médio de nutrientes digestíveis totais foi de 72,39%. Houve aumento linear da ingestão de matéria seca e de nutrientes digestíveis totais por dia e por peso metabólico, com o aumento de polpa cítrica na dieta. O mesmo ocorreu com a quantidade de nitrogênio ingerido, absorvido, urinário e retido. O aumento da participação da polpa cítrica peletizada até 55% da matéria seca da dieta, substituindo o grão de milho, implicou em melhor aproveitamento da fibra e eficiência no metabolismo do nitrogênio.The experiment was developed at Instituto de Zootecnia in São José do Rio Preto, SP, and the objective was to evaluate the digestibility coefficients, the nutrients intake, and the nitrogen balance of diets with 20% of corn silage and 80% of concentrate and 0, 25, 40 and 55% of citrus pulp in total dry matter, replacing corn grain. Eight crossbred lambs, with nine months of age and 34 kg of liveweight, were fed in individual cages, where feces and urine could be separated. During six days, feed, orts, feces and urine were weighed and sampled. The amount of feed offered was the mean of the intake in the last three days of the adaptation period. The experiment consisted of two phases, using the same animals, which were blocked by liveweight. Data were analyzed by regression. There was linear increase in the apparent digestibility coefficients of the crude protein and of the acid detergent fiber with higher levels of citrus pulp. The digestibility coefficients did not differ and means were, respectively: 71.8, 73.3, 77.2, 63.5, and 72.2%, for dry matter, organic matter, ether extract, neutral detergent fiber and hemicellulose. The total digestible nutrients mean was 72.39%. Increasing citrus pulp in the diet caused a linear and significant increase of dry matter and total digestible nutrients intake by day and by metabolic weight. Similar effects were observed for the amount of ingested, absorbed, urinary and retained nitrogen. An increasing proportion of citrus pulp up to 55% of the dietary dry matter, replacing corn grain, resulted in improvement of the fiber utilization and of the efficiency of nitrogen metabolism.

  15. Rendimento endimento de grãos e componentes de rendimento do feijoeiro em função da aplicação foliar de doses crescentes de molibdênio = Grain yield and production components of the bean plant as a result of the application of increasing doses of molybdenum

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    André Assis Pires

    2007-01-01

    Full Text Available Avaliou-se a influência de doses elevadas de molibdênio aplicadas via foliar sobre componentes de produção e rendimento de grãos dos feijoeiros Novo Jalo e Meia Noite. Conduziu-se o experimento entre março e junho de 2002 em Coimbra, Estado de Minas Gerais, utilizando delineamento em blocos casualizados, com quatro repetições,arranjados no esquema fatorial 7 x 2, (sete doses de Mo combinadas com os cultivares Novo Jalo e Meia Noite. As doses 80 e 160 g ha-1 foram aplicadas 20 dias após a emergência (DAE das plântulas em dose única. As doses (320 e 640 g ha-1 foram ministradas em trêsaplicações (15, 20 e 25 DAE, e as doses (1.280 e 2.560 g ha-1 em quatro aplicações (15, 20, 25 e 30 DAE. Os componentes de produção, exceto o número de sementes por vagem e o rendimento de grãos foram influenciados pela adubação molíbdica. A dose ótima estimada de Mo para o feijoeiro, em ambos os cultivares, foi de 255 g ha-1. Doses de molibdênio até 2.560 g ha-1 não promoveram decréscimos em nenhum dos componentes da produção nem no rendimento de grãos.The influence of high doses of molybdenum through foliar application was evaluated on production components and grain yield of the bean plants Novo Jalo and Meia Noite. The experiment was carried out fromMarch to June, 2002, on Coimbra, Minas Gerais State. A randomized block design, with four repetitions, arranged in the factorial outline 7 x 2 (seven doses of molybdenum combined with Novo Jalo and Meia Noite cultivars was used. The doses 80 and 160 g ha-1 were applied 20 days after the plantules emergence (DAE in only dose. The doses (320 and 640 g ha-1 were applied in three applications (15, 20 and 25 DAE, and the doses (1,280 and 2,560 g ha-1 in four applications (15, 20, 25 and 30 DAE. The production components,except the number of seeds for green bean and the income of grains, were influenced by the molybdenum fertilization. The expected optimum rate of molybdenum for the bean plant, in both cultivars, was of 255 g ha-1. Molybdenum doses up to 2,560 g ha-1 did not decrease any of the components of the production nor the grain yield.

  16. Balanço de nitrogênio e estimativas de perdas endógenas em vacas lactantes alimentadas com dietas contendo palma forrageira e teores crescentes de uréia e mandioca = Nitrogen balance and endogenous loss estimate in lactating cows fed with diets of forage cactus and increasing levels of urea and cassava

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    Maria Cláudia Soares Cruz

    2006-01-01

    Full Text Available Foram avaliados os efeitos da substituição do farelo de soja pela mistura uréia mais mandioca, em rações constituídas de palma, silagem de sorgo e concentrado, sobre concentrações de uréia, balanço de nitrogênio (N e estimativas de perdas endógenas totais em 8 vacas Girolando em lactação, distribuídas em dois quadrados latinos simultâneos (4x4. As concentrações de uréia e N-uréico no plasma e leite, em mg/dL e N-uréico no leite (g/dia não foram afetadas pelo aumento do nível de uréia na ração, apresentando médias de 31,37;14,62; 37,43; 17,44; 5,37. As excreções urinárias de uréia e N-uréico também não foram influenciadas, com médias de 249,45 e 116,24 mg/kg PV. Igualmente, o balanço de N não foi afetado pelos tratamentos, cujos valores médios foram de 87,75; 87,63; 62,91; 60,97 g/dia,respectivamente, para 0%, 1,00%, 1,90% e 2,86% de uréia na ração. As estimativas das perdas endógenas variaram de acordo com o sistema de exigência nutricional utilizado.The effects of the soybean when replaced by a mixture of urea and cassava, in rations composed of forage cactus, sorghum silage and concentrate, were assessed on: (i urea concentration; (ii nitrogen (N balance; and (iii total endogenous loss estimate. Eight lactating Holstein/Zebu cows were distributed in two 4x4 simultaneous latin squares. Urea and N-urea concentration in plasma and milk (mg dL-1, and milk N-urea (g day-1 were not affected by the increase of urea levels in the ration; their means were 31.37, 14.62, 37.43, 17.44, and 5.37, respectively. Also, urea and N-urea urinary excretion were not affected by the increase of urea levels in the ration, and the mean values of those parameters were 249.45 and 116.24 mg kg-1 LW, respectively. The treatments did not influence N levels, with average values of 87.75, 87.63, 62.91, and 60.97 g day-1 to 0, 1.06, 2.12 e 3.20 % of urea addition in the ration, respectively. The endogenous loss estimate varied according to the nutritional demand system used.

  17. Tendência dos acidentes de trânsito em Campinas, São Paulo, Brasil: importância crescente dos motociclistas Trends in traffic accidents in Campinas, São Paulo State, Brazil: the increasing involvement of motorcyclists

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    Leticia Marín-León

    2012-01-01

    Full Text Available Com o objetivo de descrever a tendência de ocorrência de acidentes de trânsito, sua mortalidade, tipo de veículo envolvido, tamanho da frota e perfil das vítimas em Campinas, São Paulo, Brasil, entre 1995 e 2008, foram estimadas taxas de motorização e ocorrência de acidentes, letalidade, mortalidade proporcional, taxas de mortalidade e razões entre taxas. A frota de motocicletas cresceu 241%. Apesar da queda da letalidade dos acidentes de ocupantes de motos entre 2000 e 2008, esta categoria representou 49,3% do total de acidentes fatais em vias públicas em 2008. As motos foram responsáveis pelas maiores taxas de atropelamento (66,7 atropelados/mil acidentes e de atropelamentos seguidos de morte (4 óbitos/mil acidentes. Os homens mantiveram risco de morrer no trânsito muito superior ao das mulheres. Nos atropelamentos, predominaram elevadas taxas de mortalidade em idosos; entre os ocupantes de veículos, os mais atingidos foram os de 15 a 29 anos. Na faixa de 15 a 39 anos, entre 2006 e 2008, quase 80% eram ocupantes de moto. Ações pluri-institucionais devem priorizar a prevenção de acidentes entre motociclistas.In order to describe trends in traffic accidents, mortality, vehicle types, fleet sizes, and victims' characteristics in Campinas, São Paulo State, Brazil, from 1995 to 2008, this study analyzed vehicle rates, traffic accident rates per inhabitant and per vehicle, case-fatality rates, proportional mortality, mortality rates, and rates ratios. The motorcycle fleet increased 241%. Although the case-fatality rate of motorcycle users from 2000 to 2008 decreased, in 2008 they accounted for 49.3% of fatal accidents on public byways in Campinas. Motorcycles were responsible for the highest run-over rate (66.7 pedestrians/1,000 accidents and highest pedestrian fatality rate (4 deaths/1,000 accidents. Men showed much higher mortality rates than women. Pedestrian victims were mainly elderly; most vehicle occupants in traffic accidents were in the 15 to 29-year age bracket. From 2006 to 2008, nearly 80% of vehicle users 15 to 39 years of age were motorcyclists. Motorcycle accident prevention should be a priority, using multi-institutional measures.

  18. Composição tecidual e centesimal e teor de colesterol da carne de cordeiros terminados em confinamento com dietas contendo níveis crescentes de resíduo úmido de cervejaria Tissue and centesimal composition and cholesterol of the meat of lambs feedlot with diets with different levels of brewery's residue

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    Sérgio Carvalho

    2008-10-01

    Full Text Available Este estudo teve como objetivo avaliar a influência de diferentes níveis de substituição do alimento concentrado por resíduo úmido de cervejaria sobre a composição tecidual, a composição centesimal e o teor de colesterol da carne de cordeiros terminados em confinamento. Foram utilizados 25 cordeiros, machos, não-castrados, da raça Texel, distribuídos aleatoriamente em cinco tratamentos compostos por níveis de substituição do alimento concentrado por resíduo úmido de cervejaria, sendo: 0%, 25%, 50%, 75% e 100% de substituição. Foram utilizadas uma dieta composta de feno de Tifton-85 e uma mistura concentrada em uma relação volumoso: concentrado de 40:60, com base na matéria seca (MS. O alimento concentrado foi constituído por milho desintegrado, farelo de soja, mistura mineral e resíduo úmido de cervejaria, sendo que suas proporções variaram de acordo com os tratamentos. As dietas foram formuladas para serem isoprotéicas, baseados no teor de proteína bruta (PB do tratamento com maior nível de resíduo. Os cordeiros foram abatidos após um período experimental de 77 dias. Observou-se, na secção entre a 9ª e a 11ª costelas, que os pesos de osso, músculo e gordura diminuíram linearmente e a proporção de músculo aumentou linearmente com o incremento do nível de resíduo. Verificou-se aumento linear na proporção de umidade no músculo Longissimus dorsi com o aumento do resíduo úmido de cervejaria nas dietas dos cordeiros.The purpose of this experiment was to evaluate the influence of different levels of substitution of the concentrate by brewery's residue on the tissue composition, centesimal composition and cholesterol content in the meat of lambs finished in feedlot. Twenty-five male, non castrated Texel lambs were used, distributed in five treatments, which consisted in the levels of brewery's residue replacing concentrate, being 0%, 25%, 50%, 75% and 100% of substitution. Diet's composition was Tifton-85 hay and concentrate mixture, in a relation roughage:concentrate of 40:60, on dry matter (DM. The concentrate was composed of corn ground grain, soybean meal, mineral mix and brewery's residue, and its proportion varied in accordance with the treatments. The diets were formulated to be isoproteics, based on the crude protein (CP level of the treatment with the higher level of residue. The lambs were slaughtered after 77 days of experiment. It was observed, in the section between 9th and 11th ribs, that the weights of bone, muscle and fat had linearly decreased, and the proportion of muscle had linearly increased with the increase of the level of the residue. There was a linear increase in the proportion of humidity in the Longissimus dorsi muscle with the increase of the brewery's residue on the lamb's diets.

  19. Spotlight on rituximab in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis: current perspectives

    Directory of Open Access Journals (Sweden)

    Moog P

    2015-11-01

    Full Text Available Philipp Moog, Klaus Thuermel Abteilung für Nephrologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany Abstract: A 54-year-old patient presented to his general practitioner because of strong muscle pain in both thighs. Inflammatory parameters (CRP 16.3 mg/dL and white blood cells (15 g/L were elevated. The patient reported a weight loss of 10 kg in 4 weeks. There was no fever or any other specific symptoms. Urine dipstick examination and computed tomography of the chest were unremarkable. Because of increasing symptoms, the patient was referred to our department. Magnetic resonance tomography showed diffuse inflammatory changes of the muscles of both thighs. Neurological examination and electrophysiology revealed axonal sensorimotor neuropathy and ground-glass opacities of both lungs had occurred. Serum creatinine increased to 229 µmol/L within a few days, with proteinuria of 3.3 g/g creatinine. Kidney biopsy showed diffuse pauci-immune proliferative glomerulonephritis. Proteinase 3-specific antineutrophil cytoplasmic antibodies were markedly increased. Birmingham Vasculitis Activity Score was 35. Within 2 days, serum creatinine further increased to 495 µmol/L. Plasma exchange, high-dose glucocorticosteroids, and hemodialysis were started. The patient received cyclophosphamide 1 g twice and rituximab 375 mg/m2 four times according to the RITUXVAS protocol. Despite ongoing therapy, hemodialysis could not be withdrawn and had to be continued over 3 weeks until diuresis normalized. Glucocorticosteroids were tapered to 20 mg after 2 months, and serum creatinine was 133 µmol/L. However, nephritic urinary sediment reappeared. Another dose of 1 g cyclophosphamide was given, and glucocorticosteroids were raised for another 4 weeks. After 6 months, the daily prednisolone dose was able to be tapered to 5 mg. Serum creatinine was 124 µmol/L, proteinuria further decreased to 382 mg/g creatinine, and the Birmingham

  20. Efeito de dietas com níveis crescentes de caroço de algodão integral sobre a composição química e o perfil de ácidos graxos da carne de cordeiros Santa Inês Effect of diets with increasing levels of whole cotton seed on chemical composition and fatty acid profile of Santa Inez (Santa Inês lamb meat

    Directory of Open Access Journals (Sweden)

    Marta Suely Madruga

    2008-08-01

    Full Text Available Esta pesquisa foi realizada com o objetivo de avaliar o efeito da inclusão (0, 20, 30 e 40% de caroço de algodão integral (Gossypium hirsutum na dieta sobre a composição química e o perfil de ácidos graxos da carne de cordeiros Santa Inês. Foram utilizados 24 cordeiros machos não-castrados (peso corporal inicial de 19,0 ± 0,2 kg e 4 meses de idade, todos criados em regime de confinamento em baias individuais. Os níveis de caroço de algodão integral não afetaram a composição centesimal e os percentuais de colesterol e fosfolipídios da carne ovina. Entretanto, houve diferença entre os percentuais dos ácidos graxos mirístico, palmítico e linolênico e entre a relação C18:0 + C18:1 / C16:0. Do ponto de vista nutricional, a utilização de caroço de algodão integral na dieta pode ser recomendada, durante períodos curtos, em níveis de até 40% para ovinos em terminação. Ressalta-se que o caroço de algodão integral é um subproduto economicamente viável por apresentar baixo custo de produção em comparação ao milho e à soja.The objective of this research was to evaluate the effect of inclusion (0, 20, 30 and 40% of whole cottonseed (Gossypium hirsutum in the diet on chemical composition and fatty acids profile of Santa Inez sheep meat. Twenty four no castrated male sheep were used, (initial 19.0 ± 0.2 kg BW and 4 month old, all kept in confinement regime in individual stalls. The levels of whole cottonseed did not affect chemical composition and the percentages of cholesterol and phospholipids of the lamb meat. However, there was difference among the percentages of the miristic, palmitic and linolenic fatty acids and also to the relationship C18:0 + C18:1 / C16:0. At nutritional point of view, the utilization of whole cottonseed could be recommended, during short periods, up to the level of 40% for finishing animals. In addition, whole cottonseed is a by-product economically viable for presenting low production cost as compared to corn and soybean.

  1. DYNAMICS OF THE RUMINAL FERMENTATION IN SHEEP FEEDING WITH RATION CONTAINING DIFFERENT LEVELS OF CASHEW BY-PRODUCTS (Anacardium occidentale Efecto de la inclusion en los níveles crescentes del subproducto de caju (Anacardium occidentale L. en la dinámica de la fermentacion ruminal de ovinos DINÂMICA DA FERMENTAÇÃO RUMINAL EM OVINOS ALIMENTADOS COM RAÇÕES CONTENDO DIFERENTES NÍVEIS DE COPRODUTOS DE CAJU (Anacardium occidentale

    Directory of Open Access Journals (Sweden)

    Marcos Cláudio Rogério

    2009-07-01

    Full Text Available

    The study aimed to evaluate the inclusion of cashew by-product (Anacardium occidentale L. on the ammoniac nitrogen concentrations (N-NH3, pH and vollatile fatty acids concentrations (VFA of the ruminal fluid, in sheep that received diets containing the cited by-product. Twenty male, entire sheep had been distributed in four treatments with different levels of cashew by-product inclusion (zero; 19%; 38%; 52% in a randomized block design, in a split-plot project, having in the parcels the diets and the sub-parcels the times of collection (zero, two, five, eight hours after-feeding with five replications. PH was remained inside of the normal standards cited by same literature in the raised cashew by-product inclusions. Diets with zero and 52% had gotten the biggest concentrations of N-NH3. The molar ratio of the AGV in the ruminal liquid in the diets with cashew by-product was typical of rich diets in voluminous. The relation acetate: propionate was not affected by the inclusion of the cashew by-product. The inclusion of the cashew by-product in up to 19 % of the dietary total presented better resulted in that it says respect to the parameters analyzed in this work.

    KEY WORDS: Ammoniac nitrogen, Ovis aries, pH, parameters ruminate, ruminants, volatile fatty acids.

    El estudio apunto evaluar la inclusión del subproducto de caju (Anacardium occidentale en la concentración de nitrogeno amoniacal (N-NH3, el pH y las concentraciones de los acidos grasos vollatiles (AGV en el liquido ruminal de ovinos que recibieron las dietas experimentales isofibrosas y isoproteic que contiene el subproducto en el niveles crescientes. Veinte ovinos machos habon distribuido en cuatro tratamientos con niveles de inclusion del subproducto de caju (cero, 19%, 38%, 52% en un diseno de bloque al azar, en parcelas sudivididas, teniendo en los parcelas las dietas y los su-parcelas los tiempos de la coleccion (cero, dos, cinco y ocho horas despues de alimentacion con cinco replicas. El pH se mantuvo dentro de los estándares normales citados en la literatura, cuando en alta inclusion del subproducto de caju. Los tratamientos cero y el 52% presentaron las mayores concentraciones de N-NH3. La proporción de moles de AGV en lo liquido ruminal en las dietas con subproducto de caju era típica de dietas ricas en volumoso. La relacion acetato: propionato no se afectou por la inclusión del subproducto del caju. La inclusión del subproducto de caju en 19% de la dieta total presento mejores resultados en los parámetros analizados en este trabajo.

    O presente estudo foi desenvolvido para avaliar a influência da inclusão de diferente

  2. National Response Plan

    Science.gov (United States)

    2004-12-01

    and Red Crescent Movement. The Movement consists of 181 Red Cross and Red Crescent Societies throughout the world. The American Red Cross...the world at the request of sister Societies . International Services also offers international and family tracing services with the capacity to...received by the audience with credibility. Multilanguage Communications: The incident communications team ensures that non-English- speaking

  3. GETDB: 113428 [GETDB

    Lifescience Database Archive (English)

    Full Text Available iform epi, tr. proximal crescent in leg, initially ubiquitous. wg margin, leg - - comment1:C, comment2:59B2-...l crescent in leg, Adult GFP initially ubiquitous. wg margin, leg Lethality - Also known as - Original Comments comment1:C, comment

  4. GETDB: 113442 [GETDB

    Lifescience Database Archive (English)

    Full Text Available stage12, later uni epi (SG) pns, cns, epi dorsal crescent in femur internal - - comment1:C, comment2:15F d1...arval X-gal dorsal crescent in femur Adult GFP internal Lethality - Also known as - Original Comments comment1:C, comment

  5. 75 FR 72836 - Notice of Availability of Final Environmental Impact Statement for the Tonopah Solar Energy...

    Science.gov (United States)

    2010-11-26

    ...: 14X5017] Notice of Availability of Final Environmental Impact Statement for the Tonopah Solar Energy Crescent Dunes Solar Energy Project, Nye County, NV AGENCY: Bureau of Land Management, Interior. ACTION... (BLM) has prepared a Final Environmental Impact Statement (EIS) for the Crescent Dunes Solar...

  6. Antineutrophil cytoplasmic autoantibodies in ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Vodjgani M

    2000-10-01

    Full Text Available Antineutrophil cytoplasmic autoanibodies (ANCA were detecte in patients with certain autoimmune vascular disease such as Wegner’s granulomatosis, polyarthrits nodosa and systemic luuc erythematous. Indirect immunofluorescence (IIF technique was employed to detec these autoantibodies.ANCA have been recently detected in some forms of inflammatory bowel disease (IBD, ulcerative colitis (U.C. Crohn’s disease (C.D and primary sclerosing cholangitis (PSC. By IIF method, two general patterns of ANCA were seen: a cytoplasmic (C-ANCA and perinuclear form (P-ANCA. In this study we evaluated the presece of ANCA in 52 U.C. patients and 69 matched normal control group by IIF technique, and it’s relationship with disease activity. Site of colon involvement and, lesion extent. The results showed that all control group were ANCA negative, but 58% of patients had ANCA, and most cases (70% had C- ANCA. The obtained results also revealed that there was no relationship between ANCA and disease activity

  7. Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

    Directory of Open Access Journals (Sweden)

    Omar I. Saadah

    2013-01-01

    Full Text Available Background. It is unusual for the antineutrophil cytoplasmic antibody with cytoplasmic pattern (cANCA to present in patients with inflammatory bowel disease (IBD without vasculitis. The purpose of this study was to describe the occurrence and characteristics of pediatrics IBD with cANCA. Methods. A retrospective review of pediatric IBD associated with cANCA serology in patients from King Abdulaziz University Hospital, Saudi Arabia, between September 2002 and February 2012. Results. Out of 131 patients with IBD screened for cANCAs, cANCA was positive in 7 (5.3% patients of whom 4 had ulcerative colitis and 3 had Crohn's disease. The median age was 8.8 years (2–14.8 years. Six (86% were males. Of the 7 patients, 5 (71% were Saudi Arabians and 2 were of Indian ethnicity. The most common symptoms were diarrhea, abdominal pain, weight loss, and rectal bleeding. None had family history or clinical features suggestive of vasculitis involving renal and respiratory systems. No difference in the disease location or severity was observed between cANCA positive and cANCA negative patients apart from male preponderance in cANCA positive patients. Conclusion. The occurrence of cANCA in pediatric IBD is rare. Apart from male preponderance, there were no peculiar characteristics for the cANCA positive patients.

  8. Churg-Strauss vasculitis and idiopathic hypereosinophyl syndrome: role of molecular biology in the differential diagnosis of hypereosinophyl syndrome

    Directory of Open Access Journals (Sweden)

    A. d'Ascanio

    2011-09-01

    Full Text Available Objective: Hypereosinophilic syndromes are a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia, tissue eosinophilia, or both, resulting in a wide variety of clinical manifestations, often without an identifiable cause. Churg-Strauss syndrome is a systemic vasculitis characterized by prominent peripheral eosinophilia, asthma and systemic involvement. The presence of mild to severe eosinophilia and systemic involvement raise the search of many trigger factor that need to be ruled out. Distinguishing CSS from idiopathic hypereosinophilic syndrome may be particularly challenging, especially in ANCA negative patients. Methods: The aim of the present study was to present a small case series of patients referred to a Rheumatology Unit for mild to severe eosinophilia and signs and symptoms of systemic involvement and to outline the clinical significance of molecular biology in the work-up of hypereosinophilia. Results: Eleven patients with moderate to severe peripheral eosinophylia, were referred to our Unit from 1996 to 2007. Female to male ratio was 7/4, mean age 40.54 (range 22-75. Three out of eleven patients resulted positive for molecular biology. The diagnosis of idiopathic hypereosinophylia was confirmed in one out of three on the basis of the clinical picture and bone marrow biopsy. Conclusions: Molecular biology may be useful in the screening and in the follow-up of a new hypereosinophylic patient.

  9. Electron Distribution Functions in the Diffusion Region of Asymmetric Magnetic Reconnection

    Science.gov (United States)

    Bessho, N.; Chen, L.-J.; Hesse, M.

    2016-01-01

    We study electron distribution functions in a diffusion region of antiparallel asymmetric reconnection by means of particle-in-cell simulations and analytical theory. At the electron stagnation point, the electron distribution comprises a crescent-shaped population and a core component. The crescent-shaped distribution is due to electrons coming from the magnetosheath toward the stagnation point and accelerated mainly by electric field normal to the current sheet. Only a part of magnetosheath electrons can reach the stagnation point and form the crescent-shaped distribution that has a boundary of a parabolic curve. The penetration length of magnetosheath electrons into the magnetosphere is derived. We expect that satellite observations can detect crescent-shaped electron distributions during magnetopause reconnection.

  10. Association of proteinuria with various clinical findings and morphologic variables of oxford classification in immunoglobulin a nephropathy patients

    Directory of Open Access Journals (Sweden)

    Hamid Nasri

    2013-01-01

    Conclusions: Our findings firstly support the prognostic value of crescent due to its association with proteinuria and secondly imply the importance of treatment of proteinuria to prevent progression of IgAN.

  11. Research proposal : The Seasonal Spatial Ecology and Movements of the Bullsnake, Pituophis catenifer

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This research proposal details a two year study of the bullsnakes (Pituophis catenifer) at Crescent Lake National Wildlife Refuge. The primary goal of this...

  12. Ecology and management of the Bullsnake, Pituophis catenifer sayi, in the Nebraska Sandhills : Final report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final report for the study of bullsnake ecology and management at the Crescent Lake National Wildlife Refuge This study was initiated with the primary goal of using...

  13. Folha rota, de Machado de Assis: mulheres livres e pobres na ordem patriarcal

    National Research Council Canada - National Science Library

    da Conceicao Silva, Eliane

    2009-01-01

    Este artigo analisa o conto Folha rota (1878), de Machado de Assis, levando-se em conta o processo de transformacao do patriarcalismo, haja vista sua decadencia no contexto de crescente urbanizacao durante o seculo XIX...

  14. Biologico transgenico dalla parte di Hermes

    National Research Council Canada - National Science Library

    Giuseppe Di Gregorio

    2003-01-01

    ... rilevante nel pensiero sociale; non solo per quanto riguarda la comunicazione interpersonale ma anche, e in misura crescente, per quanto riguarda l'analisi dei mezzi di comunicazione e del loro impatto sulla società...

  15. Renewal of the Nellis Air Force Range Land Withdrawal Legislative Environmental Impact Statement. Volume 2: Comments, Responses, and Appendices

    Science.gov (United States)

    1999-03-01

    California floater True Bugs Pelocoris shoshone shoshone Pahranagat naucorid bug Beetles Aegialia crescenta Crescent Dune aegialian scarab Aegialia...White bearpoppy; Merriam b. Asclepias eastwoodiana Eastwood milkweed Astragalus aequalis Clokey milkvetch; equal m. Astragalus amphioxys var

  16. TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis : Clinical and experimental considerations

    NARCIS (Netherlands)

    Huugen, Dennis; Tervaert, Jan Willem Cohen; Heeringa, Peter

    2006-01-01

    Wegener's granulomatosis, microscopic polyangiitis, idiopathic necrotizing crescentic glomerulonephritis, and Churg-Strauss syndrome are associated with the presence of ANCA with specificity for myeloperoxidase or proteinase 3. Current therapy consists mainly of corticosteroids and cyclophosphamide,

  17. Sulle Orme Del Gigante: Cristina Scarlat (A Cura Di), Mircea Eliade Once Again, Lumen, Iasi, 2011

    National Research Council Canada - National Science Library

    Lara SANJAKDAR

    2012-01-01

    Negli ultimi anni il crescente interese per la persona e l’opera di Mircea Eliade ha originato una vera e propria esplosione di pubblicazioni dedicate allo studioso, e anche la comparsa postuma di molti scritti inediti...

  18. AJINT

    African Journals Online (AJOL)

    analyzed. fit presentation, 2990 had severe acute disease requiring dialysis. Dn discharge, 60 .... Fourth Task Force Report on the Diagnosis, Evaluation, ... biopsy showed severe crescents in five patients and .... Elizabeth 'J, Porter at aJ'.

  19. Pericia psicologica no abuso sexual de criancas e adolescentes

    National Research Council Canada - National Science Library

    Souto Schaefer, Luiziana; Rossetto, Silvana; Haag Kristensen, Christian

    2012-01-01

    ... crescentes os casos de falsas denuncias. Este artigo tem como principal objetivo revisar, com base na literatura nacional e internacional recente, o papel da pericia psicologica no abuso sexual infantojuvenil...

  20. T for Texas, T for Tennessee: The Origins of American Country Music Notables.

    Science.gov (United States)

    Carney, George O.

    1979-01-01

    Origins of performers, composers, publishers, and executives who have made significant contributions to country music since the late nineteenth century are examined. Most music is produced in a crescent from West Virginia to East Texas. (KC)

  1. GETDB: 113729 [GETDB

    Lifescience Database Archive (English)

    Full Text Available ch. tibial segment of leg disc: anterior ventral side is strong, gradually decreased to the anterior dorsal ...STING. crescent circle outside of wing pouch. tibial segment of leg disc: anterior ventral side is strong, gradually decrease

  2. Progressive renal disease despite immunosuppressive therapy in a patient with Wegener s granulomatosis.

    NARCIS (Netherlands)

    Klein, I.; Vervoort, G.; Steenbergen, E.; Wetzels, J.

    2008-01-01

    We present a patient with Morbus Wegener and crescentic glomerulonephritis. Treatment with cyclophosphamide and prednisolone resulted in the disappearance of signs and symptoms of systemic inflammation. However, renal function deteriorated. Renal biopsy showed evidence of continuing capillary necros

  3. There and Back Again in the Classroom and in Outreach: Astronomy and The Hobbit

    Science.gov (United States)

    Larsen, K.

    2013-04-01

    The upcoming three-film treatment of J.R.R. Tolkien's classic book The Hobbit affords astronomy educators a unique opportunity to interest the general public in trying to observe the newborn crescent moon.

  4. 78 FR 24200 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-24

    ... Non-Vessel-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF) pursuant to section 19...), Raymond M. Greer, President, Application Type: QI Change Crescent Air Freight, Ltd. (NVO & OFF), 145 Hook...

  5. Sickle Cell Disease (For Parents)

    Science.gov (United States)

    ... RBCs that are shaped like sickles, or crescent moons. This defect can cause painful episodes, serious infections, ... know they have sickle cell trait, but most babies in the United States are now tested as ...

  6. Download this PDF file

    African Journals Online (AJOL)

    USER

    2016-12-17

    Dec 17, 2016 ... 1Department of Urban and Regional Planning, Crescent University, Abeokuta, Ogun. State, Nigeria .... due to lack of integration across land ... kilometres Northeast of Lagos. Ibadan is ..... Africa, Asia and Latin America.

  7. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

    NARCIS (Netherlands)

    Summers, Shaun A.; van der Veen, Betty S.; O'Sullivan, Kim M.; Gan, Poh-Yi; Ooi, Joshua D.; Heeringa, Peter; Satchell, Simon C.; Mathieson, Peter W.; Saleem, Moin A.; Visvanathan, Kumar; Holdsworth, Stephen R.; Kitching, A. Richard

    2010-01-01

    Antimyeloperoxidase antibodies can cause crescentic glomerulonephritis and pulmonary hemorrhage. Toll-like receptors (TLRs) respond to infectious agents activating host defenses, whereas infections potentially initiate disease and provoke relapses. Neutrophils were found to be key effector cells of

  8. Red blood cells, sickle cell (image)

    Science.gov (United States)

    Sickle cell anemia is an inherited blood disease in which the red blood cells produce abnormal pigment (hemoglobin). ... abnormal hemoglobin causes deformity of the red blood cells into crescent or sickle-shapes, as seen in this photomicrograph.

  9. Substantia nigra and Parkinson disease (image)

    Science.gov (United States)

    Parkinson disease is a slowly progressive disorder that affects movement, muscle control, and balance. Part of the disease process develops as cells are destroyed in certain parts of the brain stem, particularly the crescent-shaped cell ...

  10. Ultrasonography"

    African Journals Online (AJOL)

    utero 7. Also many prospective parents see ultrasound scan as a means of learning about their future child's ... Zion Building, Kayode Obembe Crescent, Olode,. P.O. Box 29259 Sec. ..... 9-11 Midmat Publications Ibadan. 2000. 14. Sheperd MT ...

  11. Environmental Assessment: Lease with Omaha Public Power District (PPD) to Support New United States Strategic Command (USSTRATCOM) Facility and Existing Base Load

    Science.gov (United States)

    2013-02-01

    21 BIBLIOGRAPHY Schmidt, Thomas L. and Mooter, David P., Department of Forestry, Fisheries, and Wildlife, 1987. Community Forestry...Carter Lake Council Biuffs Crescent Hancock Macedonia McClelland Minden Neola Oakland Treynor Underwood Walnut Bellevue Publ ic School s

  12. Final Environmental Assessment: Lease with Omaha Public Power District (OPPD) to Support New United States Strategic Command (USSTRATCOM) Facility and Existing Base Load

    Science.gov (United States)

    2013-02-01

    21 BIBLIOGRAPHY Schmidt, Thomas L. and Mooter, David P., Department of Forestry, Fisheries, and Wildlife, 1987. Community Forestry...Carter Lake Council Biuffs Crescent Hancock Macedonia McClelland Minden Neola Oakland Treynor Underwood Walnut Bellevue Publ ic School s

  13. National Dam Safety Program. Lock 4 Embankment Waterford Flight Dam (Inventory Number N.Y. 968). Mohawk River Basin, Saratoga County, New York. Phase I Inspection Report,

    Science.gov (United States)

    1981-09-10

    ENGINEERING DATA 2.1 GEOTECHNICAL DATA a. Geology Lock 4 Embankment Waterford Flight Dam is located in the Hudson Valley section of the Valley and Ridge...River are controlled by the up- stream locks (Nos. 5 and 6) and by the Crescent Dam which forms the im- poundment for the navigation channel above Lock...River above Crescent Dan may contribute flow through the canal system. b. Discharge at Dam Site JNo discharge records are available for this site

  14. GETDB: 104650 [GETDB

    Lifescience Database Archive (English)

    Full Text Available Request - sg gut dorsolateral crescent in tarsus (pns?), fb, gut internal - - comment1:A, comment...ent1:A, comment2:43C4 Disc (Image) d1 d2 d3 Disc (number) 3 Embryo (Image) - Embryo...ut Larval X-gal dorsolateral crescent in tarsus (pns?), fb, gut Adult GFP internal Lethality - Also known as - Original Comments comm

  15. Long term azathioprine maintenance therapy in ANCA-associated vasculitis: combined results of long-term follow-up data.

    Science.gov (United States)

    de Joode, Anoek A E; Sanders, Jan Stephan F; Puéchal, Xavier; Guillevin, Loic P; Hiemstra, Thomas F; Flossmann, Oliver; Rasmussen, Nils; Westman, Kerstin; Jayne, David R; Stegeman, Coen A

    2017-08-03

    We studied whether in ANCA-associated vasculitis patients, duration of AZA maintenance influenced relapse rate during long-term follow-up. Three hundred and eighty newly diagnosed ANCA-associated vasculitis patients from six European multicentre studies treated with AZA maintenance were included; 58% were male, median age at diagnosis 59.4 years (interquartile range: 48.3-68.2 years); granulomatosis with polyangiitis, n = 236; microscopic polyangiitis, n = 132; or renal limited vasculitis, n = 12. Patients were grouped according to the duration of AZA maintenance after remission induction: ⩽18 months, ⩽24 months, ⩽36 months, ⩽48 months or > 48 months. Primary outcome was relapse-free survival at 60 months. During follow-up, 84 first relapses occurred during AZA-maintenance therapy (1 relapse per 117 patient months) and 71 after withdrawal of AZA (1 relapse/113 months). During the first 12 months after withdrawal, 20 relapses occurred (1 relapse/119 months) and 29 relapses >12 months after withdrawal (1 relapse/186 months). Relapse-free survival at 60 months was 65.3% for patients receiving AZA maintenance >18 months after diagnosis vs 55% for those who discontinued maintenance ⩽18 months (P = 0.11). Relapse-free survival was associated with induction therapy (i.v. vs oral) and ANCA specificity (PR3-ANCA vs MPO-ANCA/negative). Post hoc analysis of combined trial data suggest that stopping AZA maintenance therapy does not lead to a significant increase in relapse rate and AZA maintenance for more than 18 months after diagnosis does not significantly influence relapse-free survival. ANCA specificity has more effect on relapse-free survival than duration of maintenance therapy and should be used to tailor therapy individually.

  16. Vasculitis associated with large granular lymphocyte (LGL) leukemia: presentation and treatment outcomes of 11 cases.

    Science.gov (United States)

    Audemard, Alexandra; Lamy, Thierry; Bareau, Benoît; Sicre, Flore; Suarez, Felipe; Truquet, Florence; Salaun, Véronique; Macro, Magaret; Verneuil, Laurence; Lobbedez, Thierry; Castrale, Cindy; Boutemy, Jonathan; Cheze, Stéphane; Geffray, Loïk; Schleinitz, Nicolas; Rey, Jérôme; Lazaro, Estibaliz; Guillevin, Loïc; Bienvenu, Boris

    2013-12-01

    The association between vasculitis and large granular lymphocyte (LGL) leukemia has rarely been reported or investigated. Thus, we assessed the clinical and biological phenotypes of LGL leukemia associated with vasculitis. We studied a series of 11 patients displaying LGL leukemia associated with vasculitis (LAV). The mean age at diagnosis of LGL leukemia was 60.3 years; there were nine women and two men. The mean follow-up period was 45 months. The main LGL lineage was T-LGL (10 patients), and only one NK-LGL was identified. Clinical and biological features of T-LGL leukemia were compared with those from the 2009 French T-LGL registry. We did not find any relevant differences except that patients with LAV were predominantly female (p vasculitis was cryoglobulinemia (n = 5). Three patients presented with cutaneous leukocytoclastic angiitis, two patients had ANCA-negative microscopic polyangiitis, and one patient had giant cell arteritis. The main clinical features involved the skin, e.g., purpura (91%), arthralgia (37%), peripheral neuritis (27%), and renal glomerulonephritis (18%). The most frequent histologic finding was leucocytoclastic vasculitis (54%). The rate of complete remission was high; i.e., 80%. A minority of patients had a vasculitis relapse (27%). Three patients (27%) died; one death was related to LGL leukemia (acute infection) and the two other deaths were related to vasculitis (both with heart failure). We conclude that vasculitis is overrepresented in the population of LGL patients, LAV predominantly affects women, vasculitis preferentially affects the small vessels, and LAV has high rate of complete response. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Detection of Anti-Pentraxin-3 Autoantibodies in ANCA-Associated Vasculitis.

    Directory of Open Access Journals (Sweden)

    Amélie Simon

    Full Text Available Pentraxin 3 (PTX3, in common with myeloperoxidase and proteinase 3, is stored in human neutrophil granules and is expressed on apoptotic neutrophil surface. We therefore investigated the presence of anti-PTX3 autoantibodies (aAbs in the sera of antineutrophil cytoplasmic antibodies (ANCA-associated vasculitis (AAV patients.Presence of anti-PTX3 autoantibodies was analysed by a specific enzyme-linked immunosorbent assay in sera from 150 patients with microscopic polyangiitis (MPA, granulomatosis with polyangiitis (GPA, and eosinophilic granulomatosis with polyangiitis (EGPA, and in sera of 227 healthy subjects (HS, 40 systemic sclerosis (SSc patients, and 25 giant cell arteritis patients (GCA. Using indirect immunofluorescence on fixed human neutrophils, we also analyzed the staining pattern associated with the presence of anti-PTX3 aAbs.Anti-PTX3 aAbs were detected in 56 of 150 (37.3% of the AAV patients (versus 12 of 227 (5.3% of HS, p<0.001 and, interestingly, in 7 of 14 MPO and PR3 ANCA negative AAV patients. Moreover, by indirect immunofluorescence on fixed neutrophils, anti-PTX3 aAbs gave rise to a specific cytoplasmic fluorescence pattern distinct from the classical cytoplasmic (c-ANCA, perinuclear (p-ANCA, and atypical (a-ANCA pattern. Anti-PTX3 aAbs levels were higher in patients with active AAV as compared to patients with inactive disease.Our work suggests that PTX3 is as a novel ANCA antigen. Anti-PTX3 aAbs appear thus as a promising novel biomarker in the diagnosis of AAV, including in patients without detectable MPO and PR3 ANCA.

  18. Detection of Anti-Pentraxin-3 Autoantibodies in ANCA-Associated Vasculitis.

    Science.gov (United States)

    Simon, Amélie; Subra, Jean-François; Guilpain, Philippe; Jeannin, Pascale; Pignon, Pascale; Blanchard, Simon; Garo, Erwan; Jaillon, Sébastien; Chevailler, Alain; Renier, Gilles; Puéchal, Xavier; Bottazzi, Barbara; Mantovani, Alberto; Delneste, Yves; Augusto, Jean-François

    2016-01-01

    Pentraxin 3 (PTX3), in common with myeloperoxidase and proteinase 3, is stored in human neutrophil granules and is expressed on apoptotic neutrophil surface. We therefore investigated the presence of anti-PTX3 autoantibodies (aAbs) in the sera of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients. Presence of anti-PTX3 autoantibodies was analysed by a specific enzyme-linked immunosorbent assay in sera from 150 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA), and in sera of 227 healthy subjects (HS), 40 systemic sclerosis (SSc) patients, and 25 giant cell arteritis patients (GCA). Using indirect immunofluorescence on fixed human neutrophils, we also analyzed the staining pattern associated with the presence of anti-PTX3 aAbs. Anti-PTX3 aAbs were detected in 56 of 150 (37.3%) of the AAV patients (versus 12 of 227 (5.3%) of HS, p<0.001) and, interestingly, in 7 of 14 MPO and PR3 ANCA negative AAV patients. Moreover, by indirect immunofluorescence on fixed neutrophils, anti-PTX3 aAbs gave rise to a specific cytoplasmic fluorescence pattern distinct from the classical cytoplasmic (c-ANCA), perinuclear (p-ANCA), and atypical (a-ANCA) pattern. Anti-PTX3 aAbs levels were higher in patients with active AAV as compared to patients with inactive disease. Our work suggests that PTX3 is as a novel ANCA antigen. Anti-PTX3 aAbs appear thus as a promising novel biomarker in the diagnosis of AAV, including in patients without detectable MPO and PR3 ANCA.

  19. Association of the HLA-DRB1*0701 allele with perinuclear anti-neutrophil cytoplasmatic antibodies in Mexican patients with severe ulcerative colitis

    Institute of Scientific and Technical Information of China (English)

    Jesus K Yamamoto-Furusho; Luis Uscanga-Domínguez; Alondra Lopez-Martinez; Julio Granados

    2006-01-01

    AIM: To determine the association between the HLA-DRB1 alleles and perinuclear anti-neutrophil cytoplasmatic antibodies (p-ANCA) positive in Mexican patients with ulcerative colitis (UC).METHODS: Ninety Mexican mestizo patients (45 females) with UC, confirmed by biopsy, were studied. High resolution HLA typing was performed by PCR-SSO reverse dot blot and PCR-SSP. Molecular typing techniques were applied to define HLA-DRB1 alleles. Enzyme-linked immunosorbent assay and immunofluorescence techniques were used to detect p-ANCA.RESULTS: Forty-eight (53%) UC patients were positive for p-ANCA by ELISA and IF. We found that p-ANCA-positive UC patients had a significantly increased frequency of HLA-DR7 compared with p-ANCA-negative controls (22% vs 5.1%; pC=0.02, OR=5.2, CI 95%:1.06-37.82). Disease activity was scored as severe in 20 patients, moderate in 8, mild in 14 and no activity in the remaining 38 patients according to the Truelove and Witts criteria. Subgroup analysis showed a significantly increased frequency of the HLA-DRB1*07 allele in 15 of 20 UC patients with severe activity of UC and p-ANCA positivity [100% vs 0%; pC=0.0000001; OR=35]. No significant differences were found between p-ANCA positive patients, HLA-DR alleles and other clinical features such as extraintestinal manifestations, proctocolectomy and extension.CONCLUSION: The HLA-DRB1*07 is associated with p-ANCA positive UC Mexican patients.

  20. The successful treatment of rapidly progressive idiopathic membranoproliferative glomerulo-nephritis Type 1 in a 4-year-old male pediatric patient.

    Science.gov (United States)

    Fujinaga, S; Ohtomo, Y; Hirano, D; Nishizaki, N; Someya, T; Ohtsuka, Y; Kaneko, K; Shimizu, T

    2010-10-01

    A multivariate analysis [4] revealed that the presence of crescent formation on initial biopsy irrespective of type of membranoproliferative glomerulonephritis (MPGN) was independently associated not only with end-stage renal disease but also with post-transplantation recurrence. In this study, we reported on a 4-year-old male pediatric patient requiring hemodialysis due to rapidly progressive idiopathic MPGN Type 1 with severe nephrotic syndrome and extensive cellular crescent formation on initial biopsy. The patient had been treated intravenously (i.v.) with 9 pulses of methylprednisolone, followed by daily prednisolone, resulting in the withdrawal of dialysis within 1 month. However, since active lesions in the second renal biopsy such as cellular crescents still remained and nephrotic range proteinuria had persisted for more than 2 months, the patient received additional 3 i.v. pulses of methylprednisolone, followed by combinations of alternate-day prednisolone, mizoribine, dipyridamole and warfarin, which lead to complete remission in a short-period of time. The patient has been off the combination therapy for 10 months because the third biopsy prior to the termination of this regimen showed decreased inflammatory activity. There is currently no established protocol for children with crescentic MPGN due to a rarity of its clinicopathological presentation. This case report indicates that early treatment with multiple pulses of methylprednisolone followed by the short-term combination therapy may be of benefit for children with rapidly progressive idiopathic MPGN Type 1, even when both diffuse crescentic changes and nephrotic syndrome are present at onset.

  1. Título da página eletrónica: Creative Cities Network

    Directory of Open Access Journals (Sweden)

    Paulo Peixoto

    2013-09-01

    Full Text Available Há muito que a Unesco se interessa pelas questões urbanas. Por isso, não é de estranhar que o tema das “cidades criativas”, que casa questões urbanas com questões culturais caras à organização, tenha levado a Unesco a constituir uma Rede de Cidades Criativas. Ao constituir esta rede, a Unesco reconhece o protagonismo crescente das cidades, mas também a importância que a cultura e as atividades culturais desempenham atualmente, e de forma crescente, na dinamização e transformação urbanas. Por ...

  2. Utilização de ácidos orgânicos como substitutos a antibióticos promotores de crescimento para frangos de corte

    OpenAIRE

    Zanelato, Ewerton Anderson

    2012-01-01

    Resumo: A produção avícola vem se adaptando às crescentes necessidades do mercado consumidor cada vez mais exigente com a qualidade dos produtos. Neste contexto, tem se observado crescente restrição, em todo o mundo, ao uso de antibióticos promotores de crescimento (APC’s) nas rações. Os ácidos orgânicos surgem como uma das alternativas para substituir os APC’s na alimentação animal, uma vez que eles podem exercer uma ação sobre a flora microbiana do trato gastrointestinal favorecendo a integ...

  3. Análise da influência da qualidade em um ciclo de serviços na satisfação do cliente: estudo de caso em uma instituição de ensino.

    OpenAIRE

    2011-01-01

    Com a crescente oferta de serviços de ensino no Brasil, torna-se necessário avaliar a qualidade do serviço prestado na educação, especialmente àquelas instituições voltadas para o ensino profissionalizante, na qual há uma maior interação entre estas e o mercado de trabalho, no sentido de formar profissionais qualificados e que atendam à crescente demanda que o país apresenta atualmente. No Brasil, a avaliação da qualidade de serviços em bibliotecas tem influenciado nas avaliações das institui...

  4. O INSTRUMENTO DA LOGÍSTICA REVERSA DE RESÍDUOS ELETROELETRÔNICOS NO CONTEXTO DA OBSOLESCÊNCIA PROGRAMADA E PERCEBIDA: UM OLHAR A PARTIR DA CIDADE DE SANTA MARIA/RS

    OpenAIRE

    Luiza Rosso Mota

    2014-01-01

    Este trabalho apresenta-se a partir da Lei 12.305/2010 (Política Nacional de Resíduos Sólidos), a qual avançou muito no campo da sustentabilidade, transmitindo um forte caráter educativo e conscientizador. Entretanto, a crescente demanda e a oferta de novas tecnologias têm provocado na população um grande e crescente desejo de consumo. Nesse sentido, o objetivo da pesquisa emergiu, à luz da Lei n 12.305/2010, da extensão do instrumento da logística reversa de eletroeletrônicos ...

  5. PORTFOLIO MANAGEMENT OF LEVERAGE ITEMS FOR SUSTAINABILITY IN SIGNINGS: CASE STUDY ON A MINING COMPANY

    OpenAIRE

    TAMIRES MAGALHAES DE MELLO

    2014-01-01

    A crescente competitividade tem induzido muitas organizações a reestruturar seus processos, tornando-os mais dinâmicos e enxutos, exigindo maior flexibilidade, melhor qualidade e menor custo. Com isso, os temas sustentabilidade e compras têm apresentado crescente interesse acadêmico nos últimos anos. Em relação à sustentabilidade, sua importância se deve principalmente à atenção despertada face às mudanças climáticas causadas pela ação do Homem no meio ambiente. Devido a isso, as empresas pas...

  6. Determinação do índice de iodo a partir da composição dos óleos

    OpenAIRE

    Graça, Cristina Maria Moniz

    2010-01-01

    Os crescentes problemas associados às emissões de gases poluentes para a atmosfera, tornou necessário a implementação de programas ambientais para redução da poluição onde os incentivos à utilização de energias renováveis fazem parte dessa estratégia. Desta forma, devido ao elevado preço do combustível diesel e aos incentivos fiscais associados à utilização de combustíveis renováveis, o uso do biodiesel tornou-se economicamente atractivo. Confrontados com o uso crescente ...

  7. Flags of the night sky when astronomy meets national pride

    CERN Document Server

    Bordeleau, André G

    2014-01-01

    Many national flags display astronomical features–Sun, Moon, stars–but are they really based on existing astronomical objects? The United States flag sports 50 stars, one for each state, however none of them are linked to real stars. Further, the lunar crescent is often shaped like the Sun being eclipsed by the Moon. At times, stars are seen right next to the crescent, where the darkened disc of the moon should be! This book will present true astronomical objects and patterns highlighted on national flags and link informative capsules about these objects to the political reasons why they were chosen to adorn such an important symbol.

  8. A case of rapidly progressive IgA nephropathy in a patient with exacerbation of Crohn’s disease

    OpenAIRE

    Choi Ji-Young; Yu Chung; Jung Hee-Yeon; Jung Min; Kim Yong-Jin; Cho Jang-Hee; Kim Chan-Duck; Kim Yong-Lim; Park Sun-Hee

    2012-01-01

    Abstract Background IgA nephropathy has been reported as a renal involvement in Crohn’s disease. Crescentic IgA nephropathy, which accounts for fewer than 5% of cases of IgA nephropathy, has a poorer prognosis than other forms of crescentic glomerulonephritis. We recently experienced a case of rapidly progressive IgA nephropathy concurrent with exacerbation of Crohn’s disease. Case presentation An 18-year-old male diagnosed with Crohn’s disease underwent a hemicolectomy 2 years prior previous...

  9. Otimização do processo de projeto de uma ferramenta progressiva para a estampagem de componentes metálicos

    OpenAIRE

    Morgado, Diogo Filipe Neves

    2013-01-01

    Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica A área do projecto de ferramentas para a estampagem de elementos metálicos, “tooling”, continua a ser um dos grandes pilares de toda a indústria automóvel. A crescente necessidade das empresas em aumentar a produtividade, reduzir os tempos de resposta assim como os custos associados a cada projecto, tem colocado uma pressão crescente sobre os gabinetes de projecto. Em parceria com uma empresa de projecto e...

  10. A case report and literature review of Wegener’s granuloma combined with hyperglycemia%韦格纳肉芽肿并发高血糖症一例报告并文献复习

    Institute of Scientific and Technical Information of China (English)

    潘辉; 范临夏; 王小军; 蔡曦光

    2016-01-01

    Objective To improve the recognition of Wegener’s granuloma(WG)combined with hyperglycemia.Methods Reviewing literature of the clinical data of one patient with Wegener’s granuloma combined with hyperglycemia and the relationship between Wegener’s granuloma and hyperglycemia was analyzed.Results CT guided lung biopsy was performed,and the pathological results were as the following:the granuloma was highly considered as Wegener’s granuloma.Check the cytoplasmic ANCA (cANC):positive,nuclear week type ANCA(pANCA):negative,anti-myeloperoxidase antibody <2.0, anti-proteinase 3 antibody 144.80.After admission,the preprandial glucose and postprandial blood glucose were found to be significantly higher than that of the normal,and the blood glucose returned to normal after the patient was treated with thehormone,cyclophosphamide and SMZ.Conclusion The reason of Wegener’s granuloma(WG)combined with hyperglycemia is possible that WG can cause the damage of pancreatic islet beta cell and decrease the secretion of insulin.%目的:提高对韦格纳肉芽肿(WG)并发高血糖症的认识。方法结合一例 WG 并发高血糖症患者的临床资料进行文献复习,对 WG 和高血糖症的内在联系进行分析。结果患者入院后在 CT 引导下行肺活检,病理检查结果提示:肉芽肿性炎,高度考虑为 WG。查胞浆型抗中性粒细胞胞浆抗体(cANCA):阳性,核周型 ANCA(pANCA):阴性,抗髓过氧化物酶抗体<2.0,抗蛋白酶3抗体144.80。入院后监测血糖发现,餐前餐后血糖水平均明显高于正常,经激素+环磷酰胺+复方新诺明控制 WG 病情后血糖恢复正常。结论 WG 并发高血糖症原因可能为 WG 累及胰腺导致胰岛β细胞损伤、胰岛素内源性分泌减少。

  11. HLA-DR in Brazilian Patients with Polyarteritis Nodosa (PAN and Microscopic Polyangiitis (MPA

    Directory of Open Access Journals (Sweden)

    Alzírton de Lira Freire

    2009-01-01

    Full Text Available The aim of this study was to evaluate the frequency and clinical associations of HLA-DR alleles in Brazilian Caucasian patients with polyarteritis nodosa (PAN or microscopic polyangiitis (MPA. We evaluated 29 Caucasian patients with vasculitis classified as PAN or MPA according to the American College of Rheumatology (ACR 1990 Criteria, Chapel Hill Consensus Conference (CHCC nomenclature for vasculitis and EULAR recommendations for conducting clinical studies in systemic vasculitis. HLA-DR alleles were typed using polymerase chain reaction-amplified DNA, hybridized with sequence-specific low resolution primers. DNA obtained from 59 Caucasian healthy blood donors were used as control. In order to evaluate if a specific HLA may have influence on the clinical profile of those diseases, we also divided the patients according to Birmingham vasculitis score (BVAS and Five-Factors Score (FFS at the time of diagnosis. Increased frequency of HLA-DRB1*16 (p = 0.023 and DRB4*01 (p = 0.048 was found in patients with higher disease activity at the time of diagnosis (BVAS ≥ 22. Patients with less severe disease (FFS = 0 had a higher frequency of HLA-DRB1*03 (p = 0.011. Patients with gastrointestinal tract involvement had significantly increased frequency of HLA-DRB1*11 or B1*12 (p = 0.046, B1*13 (p = 0.021 and B3 (p = 0.008. In contrast, patients with renal disease, had higher frequency of DRB1*15 or DRB1*16 (p = 0.035 and B5 (p = 0.035. In the subgroup of patients with MPA, increased frequency of HLA-DRB1*15 was found in patients with BVAS ≥ 22 (p = 0.038 and FFS ≥ 1 (p = 0.039 suggesting that this allele is associated with more aggressive disease. Antineutrophil cytoplasmic antibodies (ANCA negative MPA patients had significantly increased frequency of HLA-DRB1*11 or DRB1*12 when compared to ANCA positive patients (p = 0.023. Our results suggest that HLA-DR alleles may influence PAN and MPA clinical expression and outcome and that in MPA they

  12. Clinical presentation and outcome prediction of clinical, serological, and histopathological classification schemes in ANCA-associated vasculitis with renal involvement.

    Science.gov (United States)

    Córdova-Sánchez, Bertha M; Mejía-Vilet, Juan M; Morales-Buenrostro, Luis E; Loyola-Rodríguez, Georgina; Uribe-Uribe, Norma O; Correa-Rotter, Ricardo

    2016-07-01

    Several classification schemes have been developed for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with actual debate focusing on their clinical and prognostic performance. Sixty-two patients with renal biopsy-proven AAV from a single center in Mexico City diagnosed between 2004 and 2013 were analyzed and classified under clinical (granulomatosis with polyangiitis [GPA], microscopic polyangiitis [MPA], renal limited vasculitis [RLV]), serological (proteinase 3 anti-neutrophil cytoplasmic antibodies [PR3-ANCA], myeloperoxidase anti-neutrophil cytoplasmic antibodies [MPO-ANCA], ANCA negative), and histopathological (focal, crescenteric, mixed-type, sclerosing) categories. Clinical presentation parameters were compared at baseline between classification groups, and the predictive value of different classification categories for disease and renal remission, relapse, renal, and patient survival was analyzed. Serological classification predicted relapse rate (PR3-ANCA hazard ratio for relapse 2.93, 1.20-7.17, p = 0.019). There were no differences in disease or renal remission, renal, or patient survival between clinical and serological categories. Histopathological classification predicted response to therapy, with a poorer renal remission rate for sclerosing group and those with less than 25 % normal glomeruli; in addition, it adequately delimited 24-month glomerular filtration rate (eGFR) evolution, but it did not predict renal nor patient survival. On multivariate models, renal replacement therapy (RRT) requirement (HR 8.07, CI 1.75-37.4, p = 0.008) and proteinuria (HR 1.49, CI 1.03-2.14, p = 0.034) at presentation predicted renal survival, while age (HR 1.10, CI 1.01-1.21, p = 0.041) and infective events during the induction phase (HR 4.72, 1.01-22.1, p = 0.049) negatively influenced patient survival. At present, ANCA-based serological classification may predict AAV relapses, but neither clinical nor serological

  13. 75 FR 9281 - General Provisions; Revised List of Migratory Birds

    Science.gov (United States)

    2010-03-01

    ... Protection of Migratory Birds and Game Mammals, February 7, 1936, United States-United Mexican States (Mexico... York (AOU 1982, 1983, 1998); Flycatcher, La Sagra's, Myiarchus sagrae--Alabama, Florida (AOU 1982, 1983..., Motacilla citreola--Alabama (AOU 1995, 1998); Warbler, Crescent-chested, Parula superciliosa--Arizona...

  14. Out of New Orleans: Race, Class, and Researching the Katrina Diaspora

    Science.gov (United States)

    Morris, Jerome E.

    2008-01-01

    The torrential rains from Hurricane Katrina, the breaking of the levees, and the subsequent flooding of New Orleans resulted in another Black Diaspora. This article focuses on Black children and families who were displaced by Hurricane Katrina but now reside in cities, towns, and suburbs outside of the Crescent City. Informed by the author's…

  15. RENAL ISCHEMIA-REPERFUSION INJURY CONTRIBUTES TO RENAL DAMAGE IN EXPERIMENTAL ANTI-MYELOPEROXIDASE-ASSOCIATED PROLIFERATIVE GLOMERULONEPHRITIS

    NARCIS (Netherlands)

    BROUWER, E.; Klok, P.A; HUITEMA, M.G.; Weening, J.J.; Kallenberg, Cees

    1995-01-01

    The occurrence of focal fibrinoid necrosis of capillary loops in the very early stages of ANCA-associated necrotizing crescentic glomerulonephritis (NCGN) and the increased prevalence of this disease at older age suggest that renal ischemia may play an additional role in its pathophysiology. In the

  16. Head Mounted Displays for Virtual Reality

    Science.gov (United States)

    1993-02-01

    image generating capabilities. 2.2.4 Color Since people are used to viewing the world in color, a full-color display would add to the realism of the...Crescent Street, Waltham, MA, undated. Lipton, L., Foundations of the Stereoscopic Cinema , New York: Van Nostrand Rheinhold Company, 1982. Martin, S. W

  17. Mathematical Modelling for the Evaluation of Automated Speech Recognition Systems--Research Area 3.3.1 (c)

    Science.gov (United States)

    2016-01-07

    TO THE ABOVE ADDRESS. University of Toronto McMurrich Building, 3rd floor 12 Queen’s Park Crescent West - 30-Jun-2013 ABSTRACT Final Report...with controlled WERs, we examined performance in an ecologically more valid assessment that used unequivocal, task-specific measures of performance

  18. Evaluation of Low Hazardous Air Pollutant Thermoset Adhesives for the Application of Rubber-to-Metal Bonding on Army Tank Pads and Road Wheels

    Science.gov (United States)

    2011-09-01

    rubber substrate during peel test (left) and after peel (right). ...............22  Figure 17. Asymetrical peel...crescent-shaped bond line is visible. All efforts were made to 23 Rubber to metal interface Figure 17. Asymetrical peel. maintain a straight bond

  19. NCBI nr-aa BLAST: CBRC-CFAM-07-0011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-07-0011 ref|NP_421849.1| hypothetical protein CC_3055 [Caulobacter crescent...us CB15] gb|AAK25017.1| hypothetical protein CC_3055 [Caulobacter crescentus CB15] NP_421849.1 4e-06 28% ...

  20. NCBI nr-aa BLAST: CBRC-MLUC-01-0541 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0541 ref|NP_421849.1| hypothetical protein CC_3055 [Caulobacter crescent...us CB15] gb|AAK25017.1| hypothetical protein CC_3055 [Caulobacter crescentus CB15] NP_421849.1 5e-05 27% ...

  1. NCBI nr-aa BLAST: CBRC-XTRO-01-0132 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0132 ref|NP_419922.1| hypothetical protein CC_1106 [Caulobacter crescent...us CB15] gb|AAK23090.1| conserved hypothetical protein [Caulobacter crescentus CB15] NP_419922.1 4e-19 26% ...

  2. NCBI nr-aa BLAST: CBRC-LAFR-01-3885 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3885 ref|NP_422131.1| peptidase, M20/M25/M40 family [Caulobacter crescent...us CB15] gb|AAK25299.1| peptidase, M20/M25/M40 family [Caulobacter crescentus CB15] NP_422131.1 8.2 27% ...

  3. Juros: o preço do dinheiro

    Directory of Open Access Journals (Sweden)

    Eli Eustáquio de Oliveira

    2010-09-01

    Full Text Available A complexidade crescente dos problemas econômico-financeiros nas empresas, face às exigências do mercado, tem ocasionado a necessidade de aplicação de técnicas de planejamento e controle dos resultados, hoje em dia, fundamentais para a efetiva prática administrativa dos negócios.

  4. On the surficial sediments of the fresh water Naini Lake, Kumaun Himalaya, India

    Digital Repository Service at National Institute of Oceanography (India)

    Jauhari, P.; Hashimi, N.H.

    The 1.4 km long and 0.45-0.25 km wide crescent shaped Naini Lake in the Nainital District of Kumaun Himalaya, India is divided by an east-west running transverse Central Ridge into two sub-basins. These northwest and southeast sub...

  5. Development and Implementation of a Scramjet Cycle Analysis Code with a Finite-Rate-Chemistry Combustion Model for Use on a Personal Computer

    Science.gov (United States)

    1993-12-01

    structural and material engineers, since many minor species can be extremely corrosive ( Askeland , 1984: 670). 2.2.2. - Equilibrium and Frozen Flow...York: McGraw-Hill, 1989. Angelucci, E. la of Military Airaft. New York: Crescent Books, 1990. Askeland , D.R. The Science and Engineering of Materials

  6. Houston-Galveston Navigation Channel Shoaling Study

    Science.gov (United States)

    2014-12-01

    Inflows BUFFALO OYSTER CEDAR DICKINSON CLEAR_CRK CHOCOLATE LIVE_OAK ERDC/CHL TR-14-14 70 Wind Wind data used in the 1990 and 2000 efforts were...m) 5 Speed(avg, m/s) 5.71 Vessel Ocean Crescent; Carol Brent; Eagle Dewall; Martin Navigator; Industrial Century Type General cargo; NA; NA

  7. Multiple post-domestication origins of kabuli chickpea through allelic variation in a diversification-associated transcription factor

    Science.gov (United States)

    Chickpea (Cicer arietieum) is a widely cultivated food legume and one of the Neolitic founder crops domesticated in the Fertile Crescent. Cultivated chickpea is classified into two types, a ‘desi’ type with smaller and darker seed coats, and a light-colored large-seeded ‘kabuli’ type, with the two t...

  8. Teoria dei giochi e teoria della politica economica

    OpenAIRE

    Carraro, C.; F. Giavazzi

    1989-01-01

    Verso la metà degli anni '70, molti economisti iniziarono a chiedersi se un ruolo attivo della politica monetaria e fiscale fosse ancora auspicabile ed efficace. I dubbi nascevano dall'osservazione che la politica economica sembrava incapace di risolvere il dilemma di un'alta inflazione e di una disoccupazione crescente in cui si trovavano i maggiori paesi industriali.

  9. Identification of RNA binding motif proteins essential for cardiovascular development

    NARCIS (Netherlands)

    S. Maragh (Samantha); R.A. Miller (Ronald); S.L. Bessling (Seneca); D.M. McGaughey (David); M.W. Wessels (Marja); B.M. de Graaf (Bianca); E.A. Stone (Eric); A.M. Bertoli Avella (Aida); J.D. Gearhart (John); S. Fisher (Shannon); A.S. McCallion (Andrew)

    2011-01-01

    textabstractBackground: We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming vasculature we posited it to be a key player in cardiogenesis w

  10. Annual Report of the Chief of Engineers, U.S. Army, on Civil Works Activities 1959

    Science.gov (United States)

    1959-01-01

    1, 460 Mount Vernon , Ind__ ---- ------------------- -4, 699, 217 Bodega Bay, Calif--------------- ---------------------------- 2, 050 Crescent City...Jones River, Del Smyrna River, Del.2- - - - Back Creek (Anne Arundel County, Md.) ... Broad Creek, Somerset County, Md Broadwater Creek, Md Cadle Creek...Md___ Neale Sound, Md__ Northeast River, Md__ Parish Creek, Md__ Patuxent River, Md_ Pocomoke River, Md_ Rhodes Point to Tylerton, Somerset County

  11. Bathymetric study of the Neotectonic Naini Lake in outer Kumaun Himalaya

    Digital Repository Service at National Institute of Oceanography (India)

    Hashimi, N.H.; Pathak, M.C.; Jauhari, P.; Nair, R.R.; Sharma, A.K.; Bhakuni, D.S.; Bisht, M.K.S.; Valdiya, K.S.

    The Naini Lake is a product of rotational movement on a NW-SE trending Nainital Fault, quite after the establishment of the drainage of a mature stream named Balia Nala. Detailed bathymetric study, permits division of this crescent-shaped lake...

  12. Restoration Moves

    Science.gov (United States)

    Albanese, Andrew; Berry, John N., III; Blumenstein, Lynn; Datema, Jay; Fialkoff, Francine; Kenney, Brian; Miller, Rebecca; Oder, Norman; Rogers, Michael; Williams, Wilda

    2006-01-01

    This article describes how the 2006 American Library Association (ALA) Annual Conference in New Orleans will long symbolize the significance of libraries and librarians to a convention city--and to the community around it. As the first major convention in the Crescent City since the ravages of Hurricane Katrina ten months earlier, the conference…

  13. Computation of nonlinear water waves with a high-order Boussinesq model

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Madsen, Per A.; Bingham, Harry

    2005-01-01

    -crested waves in shallow/deep water, resulting in hexagonal/rectangular surface patterns; crescent waves, resulting from unstable perturbations of plane progressive waves; and highly-nonlinear wave-structure interactions. The emphasis is on physically demanding problems, and in eachcase qualitative and (when...

  14. The value of wheat landraces (Editorial)

    Science.gov (United States)

    Whether man was domesticated by wheat, or wheat was domesticated by man is but two faces of the same coin; both incidents marked a turning point in human history and led to the emergence of human civilization in the Fertile Crescent of the Old World. The complex history of wheat domestication from i...

  15. The effects of bone erosion from aortic aneurysm on the regional uptake of FDG

    DEFF Research Database (Denmark)

    Louring-Andersen, J.; Law, I.

    2008-01-01

    aorta just below the carina. An abnormal crescent-shaped uptake was identified at the margin between the aneurysm and the adjacent thoracic vertebral bodies. At this site a correspondingly shaped bone erosion on CT was proof of the chronic effects of the aneurysm. There were no signs of regional...... of correlated anatomic imaging for appropriate clinical management Udgivelsesdato: 2008/7...

  16. 75 FR 81125 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2010-12-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Crescent Railroad Drawbridge across the Upper Mississippi River, mile 481.4, at Rock Island... Railroad Drawbridge, across the Upper Mississippi River, mile 481.4, at Rock Island, Illinois to open...

  17. GETDB: 104784 [GETDB

    Lifescience Database Archive (English)

    Full Text Available of cells sg dorsal crescent in leg, sg, DT internal - - comment1:A, comment2:21C4...in leg, sg, DT Adult GFP internal Lethality - Also known as - Original Comments comment1:A, comment2:21C4 Di

  18. GETDB: 112327 [GETDB

    Lifescience Database Archive (English)

    Full Text Available crescent of leg, out ring of wing - - - comment1:A, comment2:70D5 - - - - Show 1...Lethality - Also known as - Original Comments comment1:A, comment2:70D5 Disc (Image) - Disc (number) 0 Embry

  19. GETDB: 103695 [GETDB

    Lifescience Database Archive (English)

    Full Text Available etics. CyO Link to clone table - 2 1188 Link to cluster table 1188 1 Request - sg, hg - tibial crescent, sg - lethal - comment..., sg Adult GFP - Lethality lethal Also known as - Original Comments comment1:A, comment...1:A, comment2:35A1 d1 - - - Show 103695 DGRC Number 103695 Link

  20. The New Great Game: A Phase Zero, Regional Engagement Strategy for Central Asia

    Science.gov (United States)

    2007-05-23

    College Quarterly, Carlisle. Summer 2006. Barylski, Robert V. The Russian Federation and Eurasias’ Islamic Crescent. JSTOR , Europe- Asia Studies... database of federal legislation) <http://www.govtrack.us/congress/bill.xpd?bill=s109- 2749> (accessed May 1, 2007) Commonwealth of Australia