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Sample records for anca-negative pauci-immune crescentic

  1. Native and recombinant proteins to analyze auto-antibodies to myeloperoxidase in pauci-immune crescentic glomerulonephritis

    NARCIS (Netherlands)

    Boomsma, MM; Stegeman, CA; Oost-Kort, WW; Kallenberg, CGM; Moguilevsky, N; Limburg, PC; Tervaert, JWC

    2001-01-01

    The prevalence of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) directed against myeloperoxidase (MPO) in pauci-immune necrotizing crescentic glomerulonephritis (NCGN) is dependent on the assay(s) used, We investigated the frequency of MPO-ANCA as detected by different assays for MPO-ANCA in a large

  2. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

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    Ryan Kunjal

    2016-01-01

    Full Text Available Antineutrophil cytoplasmic antibody (ANCA associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN. The diagnosis was consistent with granulomatosis with polyangiitis (GPA. Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management.

  3. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy.

    Science.gov (United States)

    Kunjal, Ryan; Makary, Raafat; Poenariu, Andreea

    2016-01-01

    Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN). The diagnosis was consistent with granulomatosis with polyangiitis (GPA). Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management.

  4. Paraneoplastic Seronegative Pauci-Immune Glomerulonephritis Associated with Lung Adenocarcinoma Responds to Rituximab: A Case Report

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    Pragnan Kancharla

    2018-06-01

    Full Text Available Anti-neutrophil cytoplasmic antibodies (ANCA play an important role in the pathogenesis of pauci-immune renal vasculitis. However, in 10% of the cases, ANCA are absent. We present a case of a 64-year-old man with a chronic untreated hepatitis C virus infection and Middle Eastern thalassemia who was ANCA-negative when he was hospitalized due to acute kidney injury and accounts for an uncommon presentation of renal vasculitis. The patient had earlier reported to have undergone local lobectomy and adjuvant chemotherapy (carboplatin/pemetrexed for lung adenocarcinoma a month prior. IL-6 has been reported to be involved in the pathophysiological cascade causing pauci-immune glomerulonephritis amongst non-small cell lung cancer patients. Previous studies with subgroup analysis have demonstrated that ANCA negativity has been associated with more chronic glomerular lesions and less crescent formation, which tends to have a critical outcome in the renal system. However, our patient underwent kidney biopsy exhibiting active crescentic glomerulonephritis, pauci-immune type with 5 cellular crescents amongst 15 glomeruli. To our knowledge, this is the third reported case of ANCA-negative vasculitis with typical presentation on biopsy in non-small cell lung cancer patients.

  5. Pauci-immune crescentic glomerulonephritis in the Down′s syndrome

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    Mejda Cherif

    2013-01-01

    Full Text Available Kidney disease is a rare complication in patients with the Down′s syndrome. However, with increased survival, it appears that a growing number of these patients present with glomerulonephritis. Most cases have been reported as case reports and include lesions such as mesangiocapillary glomerulonephritis with hypo-complementemia, crescentic glomerulonephritis with anti-neutrophil cytoplasmic antibodies (ANCA, amyloidosis and immunotactoid glomerulopathy. We report the observation of a 38-year-old man with the Down′s syndrome who presented with severe renal failure, proteinuria and microscopic hematuria evolving over two months. There was no history of congenital heart disease or urinary symptoms. Percutaneous renal biopsy revealed fibrous crescents, rupture of Bowman′s capsule and peri-glomerular granuloma; there were no deposits on immunofluorescence study. Thoracic computerized tomography scan showed alveolar congestion. The patient tested negative for ANCA. At the time of reporting, the patient is on regular chronic hemodialysis. Our case illustrates a distinct entity that further expands the spectrum of renal disease known to occur in the Down′s syndrome. Early detection of the renal disorders may prevent or slow down the progression.

  6. Poor Renal Outcome of Antineutrophil Cytoplasmic Antibody Negative Pauci-immune Glomerulonephritis in Taiwanese

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    Peir-Haur Hung

    2006-01-01

    Conclusion: This study illustrates the necessity for pathologic diagnosis of pauci-immune GN despite ANCA negativity. The poor prognosis associated with ANCA negativity in this study may be partly due to delayed diagnosis since these patients frequently lacked systemic involvement.

  7. Pauci-immune necrotizing glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Sanders, Jan S F; Stegeman, Coen A; Kallenberg, Cees G M

    Pauci-immune necrotizing glomerulonephritis is the most frequent cause of rapidly progressive glomerulonephritis and, in most cases, is associated with antineutrophil cytoplasmic antibodies (ANCA). It is either the renal manifestation of Wegener's granulomatosis, microscopic polyangiitis of

  8. Bartonella Endocarditis and Pauci-Immune Glomerulonephritis

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    Raybould, Jillian E.; Raybould, Alison L.; Morales, Megan K.; Zaheer, Misbah; Lipkowitz, Michael S.; Timpone, Joseph G.; Kumar, Princy N.

    2016-01-01

    Abstract Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement. Although a pauci-immune pattern is a frequent finding in infectious endocarditis–associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti–neutrophil cytoplasmic antibody (ANCA) positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis. Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone. PMID:27885316

  9. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis

    DEFF Research Database (Denmark)

    Kain, R.; Exner, M.; Brandes, R.

    2008-01-01

    develop antibodies to rat and human LAMP-2. Finally, we show that infections with fimbriated pathogens are common before the onset of FNGN. Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN....

  10. Antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding

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    Miyeon Kim

    2015-09-01

    Full Text Available A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45th hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.

  11. ANCA-negative Churg-Strauss Syndrome

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    Syed Jamil Abdal

    2016-08-01

    Full Text Available A rare and a disease of unknown etiology, Churg-Strauss syndrome (CSS is a granulomatous necrotizing small vessel vasculitis characterized by the presence of asthma, sinusitis, and hypereosinophilia, which is initially described by Churg and Strauss in 1951. Because of its clinical and pathological features that overlap with those of the other anti-neutrophil antibody (ANCA-associated systemic vasculitides (AASVs and now the disease is classified as AASVs. The ANCA status may dictate the clinical phenotype. ANCA-positive patients are significantly more likely to have disease manifesta­tions associated with small-vessel vasculitis, including oecrotising glomemlonephritis, mononeuritis and purpura, whereas ANCA-negative cases predominantly likely to have cardiac and lung involvement. The objective of this case report is to point out the possibility of vasculitic rash in ANCA-negative CSS in a 35-year-old man and the disease rarely occurs in Bangladeshi population. We analyze the history, clinical examinations and relevant investigations related to the patient to establish the diagnosis in our department. The clinical scenario and biopsy help us to attain the diagnosis. But due to unavailability of patients' cohort we have limitations of comparison of ANCA status in Bangladeshi populations. Though ANCA-positive and ANCA-negative CSS differ phenotypically, primary therapy for both the conditions is systemic glucocorticoids. Additional immunosuppressive agents like cyclophosphamide, mycophenolate mofetil, azathioprine, rituxin1ab are occasionally added in patients with more advanced or refractory disease.

  12. Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis.

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    Veronese, F V; Dode, R S O; Friderichs, M; Thomé, G G; da Silva, D R; Schaefer, P G; Sebben, V C; Nicolella, A R; Barros, E J G

    2016-01-01

    Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs) and other autoantibodies. Here we report the case of a 49-year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs. His laboratory tests on admission showed serum creatinine of 4.56 mg/dL, white blood count 3,800/μL, hemoglobin 7.3 g/dL, urinalysis with 51 white blood cells/μL and 960 red blood cells/μL, and urine protein-to-creatinine ratio 1.20. Serum ANCA testing was positive (>1:320), as well as serum anti-myeloperoxidase and anti-proteinase 3 antibodies. Urine toxicology screen was positive for cocaine and levamisole, with 62.8% of cocaine, 32.2% of levamisole, and 5% of an unidentified substance. Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively. The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1.97 mg/dL, white blood cell count 7,420/μL, and hemoglobin level 10.8 g/dL. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.

  13. Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis

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    F.V. Veronese

    2016-01-01

    Full Text Available Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs and other autoantibodies. Here we report the case of a 49-year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs. His laboratory tests on admission showed serum creatinine of 4.56 mg/dL, white blood count 3,800/μL, hemoglobin 7.3 g/dL, urinalysis with 51 white blood cells/μL and 960 red blood cells/μL, and urine protein-to-creatinine ratio 1.20. Serum ANCA testing was positive (>1:320, as well as serum anti-myeloperoxidase and anti-proteinase 3 antibodies. Urine toxicology screen was positive for cocaine and levamisole, with 62.8% of cocaine, 32.2% of levamisole, and 5% of an unidentified substance. Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively. The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1.97 mg/dL, white blood cell count 7,420/μL, and hemoglobin level 10.8 g/dL. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.

  14. Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleading diagnoses

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    Faizan Babar

    2016-04-01

    Full Text Available Hydralazine has been used since the 1950s for the management of hypertension. Evidence for hydralazine-associated vasculitis dates to pre-ANCA (antineutrophil cytoplasmic antibodies era. This abstract describes two cases of ANCA-positive pauci-immune glomerulonephritis (GN in challenging scenarios where diagnosis was misconstrued. A comprehensive literature review was done to understand the pathogenesis of drug-induced pauci-immune GN. We have described key diagnostic features that are helpful in distinguishing idiopathic ANCA vasculitis from drug-induced vasculitis. Additionally, we have also described different treatments meant to provide therapy options with the least side effects.

  15. Mechanisms of vasculitis : How pauci-immune is ANCA-associated renal vasculitis?

    NARCIS (Netherlands)

    van Paassen, P.; Tervaert, J. W. Cohen; Heeringa, P.

    2007-01-01

    Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative

  16. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

    OpenAIRE

    Kunjal, Ryan; Makary, Raafat; Poenariu, Andreea

    2016-01-01

    Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophili...

  17. ANCA-negative limited Wegener′s granulomatosis

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    Ghosh A

    2004-03-01

    Full Text Available A 26-year-old man presented with epistaxis, nasal obstruction and a subcutaneous swelling over the left malar region with radiological evidence of a mass in the right nasal cavity. Histology of the lesions showed necrotizing granuloma with evidence of vasculitis. There was no other systemic involvement and the patient was ANCA-negative. Excellent response to systemic steroid and cyclophosphamide therapy was noted.

  18. Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia

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    Turki Al-Hussain

    2017-01-01

    Full Text Available A series of 78 cases of glomerulonephritis (GN, in which renal biopsy revealed changes of GN associated with crescent formation, were reviewed. Renal pathology findings were correlated with clinical features including patient’s age, renal function, and serologic findings. In most of the cases (71.8%, the crescents were due to immune complex-mediated GN. This was followed by pauci-immune GN (20.5% and anti-glomerular basement membrane antibody (GBM GN (7.7%. The percentage of glomeruli with crescents was the highest in cases of anti-GBM disease (mean of 93.3%, followed by pauci-immune GBM (mean of 48.2% and immune complex GN (30.9%. In cases with the pauci- immune GN, there were additional features of glomerular injury including fibrinoid necrosis, disruption of the GBM, and rupture of Bowman’s capsule. These changes were generally more pronounced in a subset of pauci-immune GN associated with serum elevation of antineutrophil cytoplasmic antibody (c-ANCA. In biopsies from patient with immune complex disease, systemic lupus erythematosus was the most common cause of crescentic GN.

  19. ANCA-associated pauci-immune glomerulonephritis in a patient with bacterial endocarditis: a challenging clinical dilemma

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    Cervi, Andrea; Kelly, Dylan; Alexopoulou, Iakovina; Khalidi, Nader

    2017-01-01

    Purpose: We report the case of a 59-year-old man with chronic hepatitis B and C infection presenting with acute kidney injury and enterococcus faecalis-infective endocarditis (IE). An elevated proteinase-3 (PR3)-ANCA and pauci-immune glomerulonephritis (GN) on renal biopsy were discovered, corresponding to ANCA-mediated GN. We conducted a literature review to assess the role of ANCA in IE and treatment implications. Methods: On systematic review of the literature, we found five previous cases...

  20. ANCA-associated pauci-immune glomerulonephritis in a patient with bacterial endocarditis: a challenging clinical dilemma.

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    Cervi, Andrea; Kelly, Dylan; Alexopoulou, Iakovina; Khalidi, Nader

    2017-01-01

    We report the case of a 59-year-old man with chronic hepatitis B and C infection presenting with acute kidney injury and enterococcus faecalis-infective endocarditis (IE). An elevated proteinase-3 (PR3)-ANCA and pauci-immune glomerulonephritis (GN) on renal biopsy were discovered, corresponding to ANCA-mediated GN. We conducted a literature review to assess the role of ANCA in IE and treatment implications. On systematic review of the literature, we found five previous cases whereby IE caused by streptococcus and bartonella species were related to ANCA vasculitis-associated GN. Most reports of IE-related GN are mediated by immune complex deposition and resolve following microbial clearance. Of the 5 cases of ANCA GN in the setting of IE, all had markedly elevated levels of PR3-ANCA with either a subacute or chronic course of infection. Patients were treated with a combination of steroids and cyclophosphamide (2/5), steroids and antibiotics alone (1/5), or with valvular replacement (2/5). Renal function was recovered in 4/5 patients. Infection is a major etiologic player in the formation of ANCA; however, the role of PR3-ANCA in IE remains unclear. Kidney biopsy is essential in differentiating IE-related GN due to infection and immune complex deposition versus ANCA-associated vasculitis. A paucity of reports on the development of GN in IE-associated ANCA vasculitis exists, highlighting the rarity of our case and lack of clear therapeutic strategies in a patient with active infection requiring immunosuppression. In this case, the patient's chronic hepatitis B and C coinfection presented a unique challenge.

  1. ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report.

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    Psychogios, Klearchos; Evmorfiadis, Ilias; Dragomanovits, Spyros; Stavridis, Athanasios; Takis, Konstantinos; Kaklamanis, Loukas; Stathis, Pantelis

    2017-03-01

    Eosinophilic granulomatosis with polyangiitis (EGPA, previously named Churg-Strauss syndrome) is a form of necrotizing vasculitis occurring in patients with asthma and eosinophilia. Ischemic stroke is a relatively rare complication of the disease. We report a case of a 63-year-old woman with multiple embolic infarcts, hypereosinophilia (for >7 years), and skin rash. Elevated cardiac enzymes and cardiac magnetic resonance imaging were consistent with endomyocarditis. The simultaneous presence of history of asthma, sinusitis, hypereosinophilia, and vasculitis led to the diagnosis of EGPA. This case contributes to the recent debate of the 2 possible presentations of the disease according to the ANCA (antineutrophil cytoplasmic antibodies) status. We furthermore underscore the need for careful differential diagnosis of the "ANCA negative" cases with persistent hypereosinophilia from the idiopathic hypereosinophilic syndrome. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  2. Crescentic glomerulonephritis: A clinical and histomorphological analysis of 46 cases

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    Ruchika Gupta

    2011-01-01

    Full Text Available Background: Crescentic glomerulonephritis (CrGN, defined as crescents involving more than 50% of the glomeruli, includes pauci-immune, immune complex-mediated and anti-glomerular basement membrane disease. Objectives: The present study was aimed at evaluating the various clinical, biochemical and histological parameters in CrGN with respect to these categories and clinical outcome. Materials and Methods: Renal biopsies diagnosed as CrGN between Jan 2008 and Feb 2010 were included. Clinical and laboratory parameters were retrieved along with the therapeutic approach and clinical outcome, wherever available. Renal biopsy slides were evaluated for various glomerular, tubulo-interstitial and arteriolar features. Appropriate statistical tests were applied for significance. Results: A total of 46 cases of CrGN were included; majority (71.7% of cases were pauci-immune (PI while 28.3% were immune complex-mediated (IC. Among clinical features, gender ratio was significantly different between PI and IC groups (P = 0.006. The various histological parameters, including proportion of cellular crescents, tuft necrosis and Bowman′s capsule rupture, were similar in both the groups. Four unusual associations, including idiopathic membranoproliferative glomerulonephritis (MPGN, multibacillary leprosy, acute lymphoblastic leukemia and C1q nephropathy were detected. Adequate follow-up information was available in 21 (46% of the patients. Of these, 11 (52.4% were dialysis-dependent at the last follow-up. Adult patients required renal replacement therapy more frequently than pediatric cases (P = 0.05. Presence of arteriolar fibrinoid necrosis also showed association with poor clinical outcome (P = 0.05. Conclusions: Crescentic glomerulonephritis remains one of the main causes of acute renal failure with histological diagnosis. Immunohistologic examination is essential for accurate classification into one of the three categories. This condition should be considered

  3. Crescentic glomerulonephritis in non-asthmatic Churg-Strauss syndrome

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    Anupma Kaul

    2014-01-01

    Full Text Available A 58-year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure. Investigations revealed marked peripheral eosinophilia and elevated perinuclear antineutrophil cytoplasmic antibody titers. Renal biopsy showed pauci-immune cre-scentic glomerulonephritis with interstitial eosinophil infiltrates. He had no history of asthma. Computed tomography of the chest and X-ray of the paranasal sinuses were normal. On Day 1, the patient developed ileal perforation. Resected ileal segments showed small vessel vasculitis with extravascular eosinophils. A diagnosis of non-asthmatic variant of Churg-Strauss syndrome was made. Renal recovery was achieved in 12 weeks with a combination therapy of corticosteroid and cyclophosphamide. The patient has been relapse-free for 12 months on oral prednisolone therapy.

  4. Crescentic glomerulonephritis in non-asthmatic Churg-Strauss syndrome.

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    Kaul, Anupma; Sharma, Raj Kumar; Jaisuresh, Krishna Swamy; Agrawal, Vinita

    2014-03-01

    A 58-year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure. Investigations revealed marked peripheral eosinophilia and elevated perinuclear antineutrophil cytoplasmic antibody titers. Renal biopsy showed pauci-immune cre-scentic glomerulonephritis with interstitial eosinophil infiltrates. He had no history of asthma. Computed tomography of the chest and X-ray of the paranasal sinuses were normal. On Day 1, the patient developed ileal perforation. Resected ileal segments showed small vessel vasculitis with extravascular eosinophils. A diagnosis of non-asthmatic variant of Churg-Strauss syndrome was made. Renal recovery was achieved in 12 weeks with a combination therapy of corticosteroid and cyclophosphamide. The patient has been relapse-free for 12 months on oral prednisolone therapy.

  5. Clinical presentation of Churg-Strauss syndrome in children. : A 12-year-old-boy with ANCA-negative Churg-Strauss syndrome.

    NARCIS (Netherlands)

    F.G.E.M. Razenberg (Femke); J.W.C.M. Heynens (Jan); G. Jan de Vries (Geeuwke); L. Duijts (Liesbeth); J.C. de Jongste (Johan); J. de Blic (Jacques); P.P.R. Rosias (Philippe)

    2012-01-01

    textabstractChurg-Strauss syndrome is an uncommon multisystem disorder characterized by asthma, eosinophilia and vasculitis. We report on a 12-year-old boy with asthma and deterioration of his general condition, who was eventually diagnosed with an ANCA-negative Churg-Strauss syndrome. The

  6. Anti-neutrophil cytoplasmic antibody negative crescentic paucimmune glomerulonephritis in a case of scleroderma with systemic lupus erythematosus overlap

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    Rohit Tewari

    2016-01-01

    Full Text Available Renal Involvement in scleroderma is a known problem and the manifestations are well described. Renal involvement in systemic lupus erythematosus (SLE is also well known. However, in scleroderma and SLE overlap syndrome, the renal findings may vary being a combination of features of immune complex mediated glomerulonephritis as well as thrombotic microangiopathy. We report a case in which the renal manifestation in such a situation was of a focal necrotising pauci-immune glomerulonephritis with crescents, anti-neutrophil cytoplasmic antibody negative. To the best of our knowledge, such manifestations have not been described before. Renal dysfunction in a normotensive setting in such a case should direct one towards evaluation for other causes and should prompt a kidney biopsy. This would be valuable in delineating the pathological process in the kidney and would help in guiding therapy.

  7. Clinical presentation of Churg-Strauss syndrome in children: A 12-year-old-boy with ANCA-negative Churg-Strauss syndrome.

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    Razenberg, Femke G E M; Heynens, Jan W C M; Jan de Vries, Geeuwke; Duijts, Liesbeth; de Jongste, Johan C; de Blic, Jacques; Rosias, Philippe P R

    2012-01-01

    Churg-Strauss syndrome is an uncommon multisystem disorder characterized by asthma, eosinophilia and vasculitis. We report on a 12-year-old boy with asthma and deterioration of his general condition, who was eventually diagnosed with an ANCA-negative Churg-Strauss syndrome. The propositus included, 50 cases of childhood Churg-Strauss syndrome have been reported. The patient characteristics and clinical characteristics of these children are summarized. The respiratory tract is most frequently involved with pulmonary infiltrates, asthma and sinusitis. Early recognition of childhood Churg-Strauss syndrome is important as delayed diagnosis can lead to severe organ involvement, and possible fatal outcome.

  8. Isolated pauci-immune pulmonary capillaritis

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    Ashok Kumar Mehrotra

    2015-01-01

    Full Text Available A young house wife presented with low grade fever, cough, haemoptysis and SOB of unknown aetiology for 40 days duration. Respiratory system examination revealed diffuse crepts and rhonchi. Other organ system examination did not reveal any abnormality. X-ray chest PA view and CT thorax showed diffuse bilateral necrotising nodular lesions of various sizes with small pleural effusion. She also had low resting oxygen saturation with falling haematocrit. Her Serum was week positive for p-ANCA and negative for MPO-ANCA. Bronchoscopy revealed continuous bloody aspirates. We could not isolate any organisms in any of the specimens from her and she was unresponsive to any of the antibiotics either. Based on the clinical, laboratory data, radiological features and positive outcome to pulse therapy of methylprednisolone and cyclophosphamide, she was diagnosed as a case of IPIPC.

  9. Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience

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    S K Rampelli

    2016-01-01

    Full Text Available There is limited data on the etiology, clinical and histopathological spectrum and outcomes of crescentic glomerulonephritis (CrGN in adult Indian population. This prospective study was done to evaluate the etiology, clinicohistological patterns and predictors of outcome of CrGN in South Indian population. All the patients received standard protocol based immunosuppression in addition to supportive care. Immune-complex glomerulonephritis (ICGN was the most common etiology (n = 31; 77.5% followed by pauci-immune glomerulonephritis (PauciGN; n = 8; 20% and anti-glomerular basement membrane disease (n = 1; 2.5%. The most common etiology of ICGN was IgA nephropathy (n = 11; 27.5% followed by lupus nephritis (n = 7; 17.5% and post-infectious glomerulonephritis (PIGN (n = 7; 17.5%. The patients with PauciGN were significantly older compared to those with ICGN (44.5 ± 15 years vs. 31.8 ± 11 years; P = 0.01. The patients with PauciGN presented with significantly higher serum creatinine (9.7 ± 4.4 vs. 6.6 ± 3.3 mg/dl; P = 0.03. The histopathologic parameters of ICGN and PauciGN were comparable except for a higher proportion of sclerosed glomeruli in ICGN. At the end of 3 months follow-up, only two patients went into complete remission (5.4%. Majority of the patients had end-stage renal failure (48.6% and were dialysis dependent and seven patients (18.9% expired. There was no signifi difference in the renal survival (10.9 ± 1.9 vs. 9.6 ± 3.3 months or patient survival (17.5 ± 2.1 vs. 17.3 ± 4.3 months. The parameters associated with adverse outcomes at 3 months were hypertension (odds ratio [OR]: 0.58; confidence interval [CI]: 0.36–0.94, need for renal replacement therapy (OR: 0.19; CI: 0.04–0.9, serum creatinine at admission (P = 0.019, estimated glomerular filtration rate (P = 0.022 and percentage of fibrocellular crescents (P = 0.022.

  10. [ANCA-negative subglottic laryngeal stenosis in childhood].

    Science.gov (United States)

    Wittekindt, C; Lüers, J-C; Drebber, U; Guntinas-Lichius, O; Hüttenbrink, K-B

    2007-10-01

    A 15-year-old female, having developed recurrent infections of the upper airway, hoarseness, dyspnea, and nasal congestion, was referred to our department. There was no history of trauma or intubation. The subglottic space was circularly narrowed. The test for c-ANCA was negative. Chest X-ray and renal function were normal. A tracheotomy was performed; the histology showed infiltrating plasma cells, but no signs of vasculitis or granulomatous inflammation. One year later the patient developed acute renal failure. Biopsy of the kidney confirmed Wegener's disease. The laryngeal stenosis completely resolved after therapy with cyclophosphamide. Juvenile Wegener's granulomatosis is extremely rare; the larynx and trachea seem to be involved more frequently in children than in adults. The positive testing of c-ANCA can support the diagnosis; however, even when c-ANCA do not test positive, the disease can never be excluded. Surgical interventions within the larynx or trachea might only be considered after ineffective therapy with immunosuppressive drugs.

  11. 'Crescent'-shaped tokamak for compact ignition

    International Nuclear Information System (INIS)

    Yamazaki, K.; Reiersen, W.T.

    1985-12-01

    A compact high-beta tokamak configuration with ''crescent''-shaped (or ''boomerang''-shaped) cross-section is proposed as a next-generation ignition machine. This configuration with a small indentation but a large triangularity is more compact than the normal dee-shaped design because of its high-beta characteristics in the first-second transition regime of stability. This may also be a more reliable next-generation compact device than the bean-shaped design with large indentation and small triangularity, because this design dose not rely on the second stability and is easily extendable from the present dee-shaped design. (author)

  12. 'Crescent'-shaped tokamak for compact ignition

    International Nuclear Information System (INIS)

    Yamazaki, K.; Reiersen, W.T.

    1986-01-01

    A compact high-beta tokamak configuration with ''crescent''-shaped (or ''boomerang''-shaped) cross section is proposed as a next-generation ignition machine. This configuration with a small indentation but a large triangularity is more compact than the normal dee-shaped design because of its high-beta characteristics in the first-second transition regime of stability. This may also be a more reliable next-generation compact device than the bean-shaped design with large indentation and small triangularity, because this design does not rely on the second stability and is easily extendable from the present dee-shaped design. (author)

  13. Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis.

    Science.gov (United States)

    Salim, Sohail Abdul; Yousuf, Tauqeer; Patel, Asha; Fülöp, Tibor; Agarwal, Mohit

    2018-02-01

    Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disease characterized by multiple organ system involvement, including renal disease, with low complement levels. We report the case of a 31-year-old woman who presented with nonspecific symptoms including fatigue, diarrhea, macular rash and abdominal pain with acute renal failure leading to end-stage kidney disease. Laboratory results showed hematuria, nephrotic range proteinuria, worsening creatinine and low C1q levels. Left kidney biopsy showed proliferative glomerulonephritis with crescent formation. She was treated with 6 months of intravenous cyclophosphamide, followed by 2 doses of intravenous rituximab (1g each), thereafter maintained on mycophenolate mofetil and glucocorticoid-based therapy. She experienced a full recovery of renal function after 12 months of dialysis dependence. Hypocomplementemic urticarial vasculitis syndrome with crescentic glomerulonephritis is a rare disease with only 5 other reported cases in literature. In our case, we document a delayed but excellent renal recovery during a 2-year follow-up. Copyright © 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  14. Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Sukesh Manthri

    2017-01-01

    Full Text Available Cetuximab-induced nephrotoxicity is very rare, occurring in less than 1% of colorectal cancer patients and not defined in other populations. We report a rare case of crescentic diffuse proliferative glomerulonephritis (GN that developed in close temporal association with cetuximab treatment. A 65-year-old female recently completed chemotherapy with cetuximab treatment for moderately differentiated oral squamous cell carcinoma. She was admitted with acute renal failure and nephrotic-range proteinuria. Laboratory data showed serum creatinine of 6.6 mg/dl and urinalysis showed proteinuria, moderate hemoglobinuria, hyaline casts (41/LPF, WBC (28/HPF, and RBC (81/HPF. Serologic studies were negative for ANA, anti-GBM, ANCA, hepatitis B, and hepatitis C. Serum C3 and C4 level were normal. Renal biopsy showed crescentic diffuse proliferative GN with focal features of thrombotic microangiopathy. Patient was started on cyclophosphamide and steroids. Her renal function did not improve on day 8 and she was started on hemodialysis. Previous reports suggest that EGFR-targeting medications can possibly trigger or exacerbate an IgA-mediated glomerular process leading to renal failure. This case suggests that cetuximab therapy may have triggered or exacerbated a severe glomerular injury with an unfavorable outcome. Treating physicians should maintain a high degree of caution and monitor renal function in patients on EGFR inhibitors.

  15. Crescent City, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Crescent City, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  16. Crescent City, California 1 arc-second DEM

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1-second Crescent City, California Elevation Grid provides bathymetric data in ASCII raster format of 1-second resolution in geographic coordinates. This grid is...

  17. Crescentic glomerulonephritis in a polar bear (Ursus maritimus).

    Science.gov (United States)

    Baba, Hiroshi; Kudo, Tomoo; Makino, Yoshinori; Mochizuki, Yasumasa; Takagi, Takayo; Une, Yumi

    2013-11-01

    Spontaneous crescentic glomerulonephritis (CrGN) in animals has only been reported in dog and sheep. We report the pathological features of CrGN in a 17-year-old male polar bear that died due to renal failure. Histologically, the lesions were characterized by fibrocellular crescents, adhesion between Bowman's capsule and the glomerular capillary tuft and an increase in the mesangial matrix in glomeruli. The proliferating cells in the crescent were partly immunopositive for cytokeratin and intensely positive for vimentin, WT-1 and α-smooth muscle actin, suggesting they originated from parietal epithelial cells. Ultrastructually, thickening of the glomerular basement membrane and loss of epithelial cell foot processes were observed with electron-dense deposits.

  18. Crescentic Glomerulonephritis in a Polar Bear (Ursus maritimus)

    Science.gov (United States)

    BABA, Hiroshi; KUDO, Tomoo; MAKINO, Yoshinori; MOCHIZUKI, Yasumasa; TAKAGI, Takayo; UNE, Yumi

    2013-01-01

    ABSTRACT Spontaneous crescentic glomerulonephritis (CrGN) in animals has only been reported in dog and sheep. We report the pathological features of CrGN in a 17-year-old male polar bear that died due to renal failure. Histologically, the lesions were characterized by fibrocellular crescents, adhesion between Bowman’s capsule and the glomerular capillary tuft and an increase in the mesangial matrix in glomeruli. The proliferating cells in the crescent were partly immunopositive for cytokeratin and intensely positive for vimentin, WT-1 and α-smooth muscle actin, suggesting they originated from parietal epithelial cells. Ultrastructually, thickening of the glomerular basement membrane and loss of epithelial cell foot processes were observed with electron-dense deposits. PMID:23856758

  19. Subtotal ablation of parietal epithelial cells induces crescent formation.

    NARCIS (Netherlands)

    Sicking, E.M.; Fuss, A.; Uhlig, S.; Jirak, P.; Dijkman, H.; Wetzels, J.; Engel, D.R.; Urzynicok, T.; Heidenreich, S.; Kriz, W.; Kurts, C.; Ostendorf, T.; Floege, J.; Smeets, B.; Moeller, M.J.

    2012-01-01

    Parietal epithelial cells (PECs) of the renal glomerulus contribute to the formation of both cellular crescents in rapidly progressive GN and sclerotic lesions in FSGS. Subtotal transgenic ablation of podocytes induces FSGS but the effect of specific ablation of PECs is unknown. Here, we established

  20. Subtotal Ablation of Parietal Epithelial Cells Induces Crescent Formation

    Science.gov (United States)

    Sicking, Eva-Maria; Fuss, Astrid; Uhlig, Sandra; Jirak, Peggy; Dijkman, Henry; Wetzels, Jack; Engel, Daniel R.; Urzynicok, Torsten; Heidenreich, Stefan; Kriz, Wilhelm; Kurts, Christian; Ostendorf, Tammo; Floege, Jürgen; Smeets, Bart

    2012-01-01

    Parietal epithelial cells (PECs) of the renal glomerulus contribute to the formation of both cellular crescents in rapidly progressive GN and sclerotic lesions in FSGS. Subtotal transgenic ablation of podocytes induces FSGS but the effect of specific ablation of PECs is unknown. Here, we established an inducible transgenic mouse to allow subtotal ablation of PECs. Proteinuria developed during doxycycline-induced cellular ablation but fully reversed 26 days after termination of doxycycline administration. The ablation of PECs was focal, with only 30% of glomeruli exhibiting histologic changes; however, the number of PECs was reduced up to 90% within affected glomeruli. Ultrastructural analysis revealed disruption of PEC plasma membranes with cytoplasm shedding into Bowman’s space. Podocytes showed focal foot process effacement, which was the most likely cause for transient proteinuria. After >9 days of cellular ablation, the remaining PECs formed cellular extensions to cover the denuded Bowman’s capsule and expressed the activation marker CD44 de novo. The induced proliferation of PECs persisted throughout the observation period, resulting in the formation of typical cellular crescents with periglomerular infiltrate, albeit without accompanying proteinuria. In summary, subtotal ablation of PECs leads the remaining PECs to react with cellular activation and proliferation, which ultimately forms cellular crescents. PMID:22282596

  1. Effects of Harbor Modification on Crescent City, California's Tsunami Vulnerability

    Science.gov (United States)

    Dengler, Lori; Uslu, Burak

    2011-06-01

    More damaging tsunamis have impacted Crescent City, California in historic times than any other location on the West Coast of the USA. Crescent City's harbor has undergone significant modification since the early 20th century, including construction of several breakwaters, dredging, and a 200 × 300 m2 small boat basin. In 2006, a M w 8.3 earthquake in the Kuril Islands generated a moderate Pacific-wide tsunami. Crescent City recorded the highest amplitudes of any tide gauge in the Pacific and was the only location to experience structural damage. Strong currents damaged docks and boats within the small boat basin, causing more than US 20 million in damage and replacement costs. We examine how modifications to Crescent City's harbor may have affected its vulnerability to moderate tsunamis such as the 2006 event. A bathymetric grid of the basin was constructed based on US Army Corps of Engineers soundings in 1964 and 1965 before the construction of the small boat basin. The method of splitting tsunamis was used to estimate tsunami water heights and current velocities at several locations in the harbor using both the 1964-1965 grid and the 2006 bathymetric grid for the 2006 Kuril event and a similar-sized source along the Sanriku coast of Japan. Model velocity outputs are compared for the two different bathymetries at the tide gauge location and at six additional computational sites in the harbor. The largest difference between the two grids is at the small boat basin entrance, where the 2006 bathymetry produces currents over three times the strength of the currents produced by the 1965 bathymetry. Peak currents from a Sanriku event are comparable to those produced by the 2006 event, and within the boat basin may have been higher. The modifications of the harbor, and in particular the addition of the small boat basin, appear to have contributed to the high current velocities and resulting damage in 2006 and help to explain why the 1933 M w 8.4-8.7 Sanriku tsunami

  2. Crescentic glomerular nephritis associated with rheumatoid arthritis: a case report.

    Science.gov (United States)

    Balendran, K; Senarathne, L D S U; Lanerolle, R D

    2017-07-21

    Rheumatoid arthritis is a systemic disorder where clinically significant renal involvement is relatively common. However, crescentic glomerular nephritis is a rarely described entity among the rheumatoid nephropathies. We report a case of a patient with rheumatoid arthritis presenting with antineutrophil cytoplasmic antibody-negative crescentic glomerular nephritis. A 54-year-old Sri Lankan woman who had recently been diagnosed with rheumatoid arthritis was being treated with methotrexate 10 mg weekly and infrequent nonsteroidal anti-inflammatory drugs. She presented to our hospital with worsening generalized body swelling and oliguria of 1 month's duration. Her physical examination revealed that she had bilateral pitting leg edema and periorbital edema. She was not pale or icteric. She had evidence of mild synovitis of the small joints of the hand bilaterally with no deformities. No evidence of systemic vasculitis was seen. Her blood pressure was 170/100 mmHg, and her jugular venous pressure was elevated to 7 cm with an undisplaced cardiac apex. Her urine full report revealed 2+ proteinuria with active sediment (dysmorphic red blood cells [17%] and granular casts). Her 24-hour urinary protein excretion was 2 g. Her serum creatinine level was 388 μmol/L. Abdominal ultrasound revealed normal-sized kidneys with acute parenchymal changes and mild ascites. Her renal biopsy showed renal parenchyma containing 20 glomeruli showing diffuse proliferative glomerular nephritis, with 14 of 20 glomeruli showing cellular crescents, and the result of Congo red staining was negative. Her rheumatoid factor was positive with a high titer (120 IU/ml), but results for antinuclear antibody, double-stranded deoxyribonucleic acid, and antineutrophil cytoplasmic antibody (perinuclear and cytoplasmic) were negative. Antistreptolysin O titer rheumatoid arthritis, awareness of which would facilitate early appropriate investigations and treatment.

  3. Beta limit of crescent and bean shaped tokamaks

    International Nuclear Information System (INIS)

    Naitou, H.; Yamazaki, K.

    1988-01-01

    The maximum attainable beta values which can be expected in tokamaks with crescent (BEAN 1) and rounded (BEAN 2) bean shaped cross-sections are obtained numerically by using the linear ideal MHD stability analysis code ERATO. The current profiles are optimized with a fixed pressure profile for high values of beta, keeping Mercier, high-n ballooning and n=1 kink modes stable. The poloidal plasma cross-sections are inscribed in a rectangle with an aspect ratio of three and an ellipticity of two. A confocal wall, the distance of which from the plasma surface is equal to the horizontal minor plasma radius, is present to stabilize against the kink mode. Depending on the shape and triangularity (indentation), a beta value of 10 to 17% is obtained. It is also shown that the coefficient of the Troyon-type beta scaling increases for an indented plasma. In the case of small indentation, the BEAN 1 type tokamaks show higher beta values than the BEAN 2 type. For strong indentation, the BEAN 2 type gives the highest beta value. (author). 29 refs, 15 figs

  4. Central retinal artery occlusion in a patient with ANCA-negative Churg-Strauss syndrome

    Science.gov (United States)

    Kumano, Yuji; Yoshida, Noriko; Fukuyama, Satoru; Miyazaki, Masanori; Enaida, Hiroshi; Matsui, Takaaki

    2012-01-01

    Ocular involvement in Churg-Strauss syndrome is infrequent. We describe the case of a 54-year-old woman with eosinophilia and involvement of the respiratory tract, skin, and peripheral nervous system, fulfilling the American College of Rheumatology criteria for Churg-Strauss syndrome. The patient presented with acute, painless vision loss in her right eye. Central retinal artery occlusion (CRAO) without accompanying retinal vasculitis was diagnosed by angiographic findings and funduscopic findings of retinal whitening with a cherry-red spot. Although her antineutrophil cytoplasmic antibody (ANCA) status was negative, CRAO was thought to be an ocular manifestation of Churg-Strauss syndrome, and appropriate treatment was planned. She was treated with high-dose corticosteroids and anticoagulant therapy. Her macular edema improved, but visual recovery was poor. Specific therapy to alter inflammation, blood coagulation, and rheology reportedly plays an important role in ANCA-positive patients with Churg-Strauss syndrome who develop CRAO. Regardless of ANCA status, high-dose corticosteroids should be considered for CRAO in patients with Churg-Strauss syndrome, as discussed in this case. PMID:22927731

  5. Expression of Tight Junction Protein Claudin-1 in Human Crescentic Glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Ryo Koda

    2014-01-01

    Full Text Available The origin of crescent forming cells in human glomerulonephritis (GN remains unknown. Some animal studies demonstrated that parietal epithelial cells of Bowman’s capsule (PECs were the main component of proliferating cells and PEC-specific tight junction protein claudin-1 was expressed in crescentic lesions. We investigated the expression of claudin-1 in human GN. Immunohistochemistry for claudin-1 was performed on 17 kidney biopsy samples with crescent formation. Colocalization of claudin-1 with intracellular tight junction protein ZO-1 was also evaluated by immunofluorescence double staining. Claudin-1 is expressed mainly at the cell to cell contact site of proliferating cells in cellular crescentic lesions in patients with these forms of human GN. Small numbers of crescent forming cells showed extrajunctional localization of claudin-1. Colocalization of claudin-1 with ZO-1 was found at cell to cell contact sites of adjacent proliferating cells. In control samples, staining of claudin-1 was positive in PECs, but not in podocytes. Our findings suggest that claudin-1 contributes to crescent formation as a component of the tight junction protein complex that includes ZO-1. Co-localization of claudin-1 with ZO-1 implies the formation of functional tight junction complexes in crescentic lesions to prevent the interstitial damage caused by penetration of filtered molecules from Bowman’s space.

  6. Recent drying of the Fertile Crescent: natural or externally forced?

    Science.gov (United States)

    Kelley, Colin

    2014-05-01

    There has been a reduction in observed precipitation over the greater Mediterranean region since the middle of the 20th Century. Recent studies suggest that while anthropogenic forcing has already begun to assert itself in recent decades, the preponderance of the winter drying trend is attributable to the large natural multidecadal variability of the North Atlantic Oscillation (NAO), while over the eastern Mediterranean, the anthropogenic, or forced drying signal is more clearly evident. This forced drying is projected to increase during the 21st Century according to the newest global climate models and this aridification would present significant challenges for a region that is already water-stressed. Although the Fertile Crescent is historically known for its agricultural prosperity, the severity and persistence of the recent multiyear drought in Syria, directly prior to the 2011 uprising there, leads us to ask whether this is evidence of emerging global warming influence. This drought exacerbated existing water insecurity, resulting in an agricultural collapse and a mass migration of rural drought refugees to the urban areas in Syria's west. This migration followed the previous influx of Iragi refugees and combined with strong natural population growth to place a severe strain on resources. Here we examine observations of precipitation and temperature, both gridded and stations, along with simulations and projections from the newest global climate models, to estimate the forced contribution to the recent Syrian drought, and assess the uncertainty in future drying according to the models. We find that this region has experienced a long-term downward trend in precipitation, and a concomitant increase in temperature, serving to further dry the soil, and in surface pressure. We find that the shift in the distributions of three-year running means of surface pressure and precipitation due to the forcing make severe events such as the recent Syrian drought several

  7. Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Slot, Marjan; van Paassen, Pieter; van Breda Vriesman, Peter; Heeringa, Peter; Tervaert, Jan Willem Cohen

    BACKGROUND: In a substantial proportion of patients with crescentic glomerulonephritis (CGN), both anti-glomerular basement membrane (GBM) antibodies and antineutrophil cytoplasmic antibodies (ANCAs) with specificity for myeloperoxidase (MPO-ANCA) are detected. In the present study, we questioned

  8. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis.

    NARCIS (Netherlands)

    Smeets, B.; Angelotti, M.L.; Rizzo, P.; Dijkman, H.; Lazzeri, E.; Mooren, F.; Ballerini, L.; Parente, E.; Sagrinati, C.; Mazzinghi, B.; Ronconi, E.; Becherucci, F.; Benigni, A.; Steenbergen, E.; Lasagni, L.; Remuzzi, G.; Wetzels, J.F.M.; Romagnani, P.

    2009-01-01

    Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space. The origin of these hyperplastic epithelial cells in different glomerular disorders is controversial. Renal progenitors localized to the inner

  9. Knowledge and Attitude of Iranian Red Crescent Society Volunteers in Dealing with Bioterrorist attacks

    Directory of Open Access Journals (Sweden)

    Seyed Ali Bahreini Moghadam

    2016-01-01

    Full Text Available Introduction: Bioterrorism is a worldwide problem and has been the focus of attention during recent decades. There is no precise information on the knowledge, attitude, and preparedness of Iranian Red Crescent volunteers in dealing with bioterrorism. Therefore, the present study aimed to evaluate the above-mentioned parameters in Mahabad Red Crescent Society volunteers. Methods: In this prospective cross-sectional study, the knowledge of 120 volunteers was evaluated and rated as poor, moderate, and good. In addition, attitude of the volunteers and preparedness of Mahabad Red Crescent Society was rated as inappropriate and appropriate using a questionnaire. Results: The mean age of volunteers was 32.0 ± 8.2 years (62.5% male. 2 (1.7% volunteers had good knowledge while 94 (78.3% had no knowledge regarding bioterrorist attack management. Only 1 (0.8%  volunteer had appropriate attitude and 6 (5.0% stated their preparedness for being sent out to the crisis zone. 116 volunteers (96.7% indicated that Mahabad Red Crescent Society has an inappropriate level of preparedness to encounter bioterrorist attacks. Conclusion: The findings of the present study showed poor knowledge and inappropriate attitude of Mahabad Red Crescent Society volunteers in encountering probable bioterrorist attacks. Furthermore, the Red Crescent Society of this town had an inappropriate level of preparedness in the field of bioterrorism from the viewpoint of the studied volunteers.

  10. Correction of Bowtie-Filter Normalization and Crescent Artifacts for a Clinical CBCT System.

    Science.gov (United States)

    Zhang, Hong; Kong, Vic; Huang, Ke; Jin, Jian-Yue

    2017-02-01

    To present our experiences in understanding and minimizing bowtie-filter crescent artifacts and bowtie-filter normalization artifacts in a clinical cone beam computed tomography system. Bowtie-filter position and profile variations during gantry rotation were studied. Two previously proposed strategies (A and B) were applied to the clinical cone beam computed tomography system to correct bowtie-filter crescent artifacts. Physical calibration and analytical approaches were used to minimize the norm phantom misalignment and to correct for bowtie-filter normalization artifacts. A combined procedure to reduce bowtie-filter crescent artifacts and bowtie-filter normalization artifacts was proposed and tested on a norm phantom, CatPhan, and a patient and evaluated using standard deviation of Hounsfield unit along a sampling line. The bowtie-filter exhibited not only a translational shift but also an amplitude variation in its projection profile during gantry rotation. Strategy B was better than strategy A slightly in minimizing bowtie-filter crescent artifacts, possibly because it corrected the amplitude variation, suggesting that the amplitude variation plays a role in bowtie-filter crescent artifacts. The physical calibration largely reduced the misalignment-induced bowtie-filter normalization artifacts, and the analytical approach further reduced bowtie-filter normalization artifacts. The combined procedure minimized both bowtie-filter crescent artifacts and bowtie-filter normalization artifacts, with Hounsfield unit standard deviation being 63.2, 45.0, 35.0, and 18.8 Hounsfield unit for the best correction approaches of none, bowtie-filter crescent artifacts, bowtie-filter normalization artifacts, and bowtie-filter normalization artifacts + bowtie-filter crescent artifacts, respectively. The combined procedure also demonstrated reduction of bowtie-filter crescent artifacts and bowtie-filter normalization artifacts in a CatPhan and a patient. We have developed a step

  11. The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases.

    Science.gov (United States)

    Rizzo, Paola; Novelli, Rubina; Rota, Cinzia; Gagliardini, Elena; Ruggiero, Barbara; Rottoli, Daniela; Benigni, Ariela; Remuzzi, Giuseppe

    2017-11-01

    Crescentic glomerulonephritis (GN) is a devastating disease with rapidly progressive deterioration in kidney function, which, histologically, manifests as crescent formation in most glomeruli. We previously found that crescents derive from the aberrant proliferation and migration of parietal epithelial cells (PECs)/progenitor cells, and that the angiotensin (ang) II/ang II type-1 (AT 1 ) receptor pathway may participate, together with the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 axis, in the development of those lesions. Herein, we elucidated sequential events and cellular and molecular interactions occurring during crescentic lesion onset and evolution. By analyzing kidney biopsy specimens of patients with extracapillary GN, divided according to the grade of glomerular lesions, we found that the accumulation of macrophages expressing matrix metalloproteinase-12 started manifesting in glomeruli affected by early-stage lesions, whereas AT 1 receptor expression could not be detected. In glomeruli with advanced lesions, AT 1 receptor expression increased markedly, and the up-regulation of SDF-1, and its receptor C-X-C chemokine receptor 7, was documented on podocytes and PECs, respectively. In vitro studies were instrumental to demonstrating the role of ang II in inducing podocyte SDF-1 production, which ultimately activates PECs. The present findings support the possibility that angiotensin-converting enzyme inhibitor treatment might limit PEC activation and reduce the frequency and extension of crescents in extracapillary GN. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  12. Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.

    Science.gov (United States)

    Zeng, Yeting; Wang, Xinrui; Xie, Feilai; Zheng, Zhiyong

    2017-08-01

    Ischemic pseudo-cellular crescent (IPCC) that is induced by ischemia and composed of hyperplastic glomerular parietal epithelial cells resembles cellular crescent. In this study, we aimed to assess the clinical and pathological features of IPCC in renal biopsy to avoid over-diagnosis and to determine the diagnostic basis. 4 IPCC cases diagnosed over a 4-year period (2012-2015) were evaluated for the study. Meanwhile, 5 cases of ANCA-associated glomerulonephritis and 5 cases of lupus nephritis (LN) were selected as control. Appropriate clinical data, morphology, and immunohistochemical features of all cases were retrieved. Results showed that the basement membrane of glomerulus with IPCC appeared as a concentric twisted ball, and glomerular cells of the lesion were reduced even entirely absent, and the adjacent afferent arterioles showed sclerosis or luminal stenosis. Furthermore, immune globulin deposition, vasculitis, and fibrinous exudate have not been observed in IPCC. While the cellular crescents showed diverse characteristics in both morphology and immunostaining in the control group. Therefore, these results indicated that IPCC is a sort of ischemic reactive hyperplasia and associated with sclerosis, stenosis, or obstruction of adjacent afferent arterioles, which is clearly different from cellular crescents result from glomerulonephritis. Copyright © 2017 Elsevier GmbH. All rights reserved.

  13. Long-term statistics of extreme tsunami height at Crescent City

    Science.gov (United States)

    Dong, Sheng; Zhai, Jinjin; Tao, Shanshan

    2017-06-01

    Historically, Crescent City is one of the most vulnerable communities impacted by tsunamis along the west coast of the United States, largely attributed to its offshore geography. Trans-ocean tsunamis usually produce large wave runup at Crescent Harbor resulting in catastrophic damages, property loss and human death. How to determine the return values of tsunami height using relatively short-term observation data is of great significance to assess the tsunami hazards and improve engineering design along the coast of Crescent City. In the present study, the extreme tsunami heights observed along the coast of Crescent City from 1938 to 2015 are fitted using six different probabilistic distributions, namely, the Gumbel distribution, the Weibull distribution, the maximum entropy distribution, the lognormal distribution, the generalized extreme value distribution and the generalized Pareto distribution. The maximum likelihood method is applied to estimate the parameters of all above distributions. Both Kolmogorov-Smirnov test and root mean square error method are utilized for goodness-of-fit test and the better fitting distribution is selected. Assuming that the occurrence frequency of tsunami in each year follows the Poisson distribution, the Poisson compound extreme value distribution can be used to fit the annual maximum tsunami amplitude, and then the point and interval estimations of return tsunami heights are calculated for structural design. The results show that the Poisson compound extreme value distribution fits tsunami heights very well and is suitable to determine the return tsunami heights for coastal disaster prevention.

  14. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis.

    Science.gov (United States)

    Smeets, Bart; Angelotti, Maria Lucia; Rizzo, Paola; Dijkman, Henry; Lazzeri, Elena; Mooren, Fieke; Ballerini, Lara; Parente, Eliana; Sagrinati, Costanza; Mazzinghi, Benedetta; Ronconi, Elisa; Becherucci, Francesca; Benigni, Ariela; Steenbergen, Eric; Lasagni, Laura; Remuzzi, Giuseppe; Wetzels, Jack; Romagnani, Paola

    2009-12-01

    Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space. The origin of these hyperplastic epithelial cells in different glomerular disorders is controversial. Renal progenitors localized to the inner surface of Bowman's capsule can regenerate podocytes, but whether dysregulated proliferation of these progenitors contributes to crescent formation is unknown. In this study, we used confocal microscopy, laser capture microdissection, and real-time quantitative reverse transcriptase-PCR to demonstrate that hypercellular lesions of different podocytopathies and crescentic glomerulonephritis consist of three distinct populations: CD133(+)CD24(+)podocalyxin (PDX)(-)nestin(-) renal progenitors, CD133(+)CD24(+)PDX(+)nestin(+) transitional cells, and CD133(-)CD24(-)PDX(+)nestin(+) differentiated podocytes. In addition, TGF-beta induced CD133(+)CD24(+) progenitors to produce extracellular matrix, and these were the only cells to express the proliferation marker Ki67. Taken together, these results suggest that glomerular hyperplastic lesions derive from the proliferation of renal progenitors at different stages of their differentiation toward mature podocytes, providing an explanation for the pathogenesis of hyperplastic lesions in podocytopathies and crescentic glomerulonephritis.

  15. Agriculture in the Fertile Crescent: Continuity and change under climate change

    Science.gov (United States)

    The Fertile Crescent is a highly biodiverse region where most temperate-zone agricultural species originated and were first domesticated. A favorable environment, a special plant community, and an adaptive population combined to initiate the transition from a hunter-gatherer economy to one based on ...

  16. China Confronts Afghan Drugs: Law Enforcement Views of The Golden Crescent

    Science.gov (United States)

    2011-03-01

    tabs of the psychoactive drug amfepramone (jingshen yaopin anfeilatong; 精神药品安非拉酮).18 Although no data are available that would permit Western... consumption market for their drugs arriving from the Golden Crescent. These analysts attribute this change in behavior to the length of time it can take to...entire global consumption of heroin.” Whenever the Taliban decide it is profitable to do so, they will begin “ferociously hurling those drugs onto the

  17. An idealised study for the long term evolution of crescentic bars

    Science.gov (United States)

    Chen, W. L.; Dodd, N.; Tiessen, M. C. H.; Calvete, D.

    2018-01-01

    An idealised study that identifies the mechanisms in the long term evolution of crescentic bar systems in nature is presented. Growth to finite amplitude (i.e., equilibration, sometimes referred to as saturation) and higher harmonic interaction are hypothesised to be the leading nonlinear effects in long-term evolution of these systems. These nonlinear effects are added to a linear stability model and used to predict crescentic bar development along a beach in Duck, North Carolina (USA) over a 2-month period. The equilibration prolongs the development of bed patterns, thus allowing the long term evolution. Higher harmonic interaction enables the amplitude to be transferred from longer to shorter lengthscales, which leads to the dominance of shorter lengthscales in latter post-storm stages, as observed at Duck. The comparison with observations indicates the importance of higher harmonic interaction in the development of nearshore crescentic bar systems in nature. Additionally, it is concluded that these nonlinear effects should be included in models simulating the development of different bed patterns, and that this points a way forward for long-term morphodynamical modelling in general.

  18. Proliferative, necrotizing and crescentic immune complex-mediated glomerulonephritis in a cat

    Directory of Open Access Journals (Sweden)

    Carolyn Gross

    2015-09-01

    Full Text Available Case Summary A 5-year-old cat was examined for vomiting and anorexia of 2 days’ duration. Azotemia, hyperphosphatemia and hypoalbuminemia were the main biochemical findings. Serial analyses of the urine revealed isosthenuria, proteinuria and eventual glucosuria. Hyperechoic perirenal fat was detected surrounding the right kidney by ultrasonography. Histopathologic evaluation of ante-mortem ultrasound-guided needle biopsies of the right kidney was consistent with proliferative, necrotizing and crescentic glomerulonephritis with fibrin thrombi, proteinaceous and red blood cell casts, and moderate multifocal chronic-active interstitial nephritis. Owing to a lack of clinical improvement, the cat was eventually euthanized. Post-mortem renal biopsies were processed for light microscopy, transmission electron microscopy and immunofluorescence. This revealed severe focal proliferative and necrotizing glomerulonephritis with cellular crescent formation, podocyte injury and secondary segmental sclerosis. Ultrastructural analysis revealed scattered electron-dense deposits in the mesangium, and immunofluorescence demonstrated positive granular staining for λ light chains, consistent with immune complex-mediated glomerulonephritis. Severe diffuse acute tubular epithelial injury and numerous red blood cell casts were also seen. Relevance and novel information To our knowledge, this is the first report of naturally occurring proliferative, necrotizing and crescentic immune complex glomerulonephritis in a cat.

  19. Effects of the reconnection electric field on crescent electron distribution functions in asymmetric guide field reconnection

    Science.gov (United States)

    Bessho, N.; Chen, L. J.; Hesse, M.; Wang, S.

    2017-12-01

    In asymmetric reconnection with a guide field in the Earth's magnetopause, electron motion in the electron diffusion region (EDR) is largely affected by the guide field, the Hall electric field, and the reconnection electric field. The electron motion in the EDR is neither simple gyration around the guide field nor simple meandering motion across the current sheet. The combined meandering motion and gyration has essential effects on particle acceleration by the in-plane Hall electric field (existing only in the magnetospheric side) and the out-of-plane reconnection electric field. We analyze electron motion and crescent-shaped electron distribution functions in the EDR in asymmetric guide field reconnection, and perform 2-D particle-in-cell (PIC) simulations to elucidate the effect of reconnection electric field on electron distribution functions. Recently, we have analytically expressed the acceleration effect due to the reconnection electric field on electron crescent distribution functions in asymmetric reconnection without a guide field (Bessho et al., Phys. Plasmas, 24, 072903, 2017). We extend the theory to asymmetric guide field reconnection, and predict the crescent bulge in distribution functions. Assuming 1D approximation of field variations in the EDR, we derive the time period of oscillatory electron motion (meandering + gyration) in the EDR. The time period is expressed as a hybrid of the meandering period and the gyro period. Due to the guide field, electrons not only oscillate along crescent-shaped trajectories in the velocity plane perpendicular to the antiparallel magnetic fields, but also move along parabolic trajectories in the velocity plane coplanar with magnetic field. The trajectory in the velocity space gradually shifts to the acceleration direction by the reconnection electric field as multiple bounces continue. Due to the guide field, electron distributions for meandering particles are bounded by two paraboloids (or hyperboloids) in the

  20. Motor carrier case study evaluation report : appendix C, Vol. 2 : case study field notes, the Crescent Evaluation

    Science.gov (United States)

    1994-02-01

    The Crescent Project element of the HELP Program is a bi-national multi-jurisdictional : cooperative research and demonstration initiative involving the public and private sectors in an : application of advanced technologies for the creation of an in...

  1. Effect of intensive plasma exchange (PE) in rapidly progressive crescentic glomerulonephritis (RPCGN).

    Science.gov (United States)

    D'Amico, G; Sinico, R; Fornasieri, A; Ferrario, F; Colasanti, G; Porri, M T; Paracchini, M L; Gibelli, A

    1983-07-01

    Ten adult patients with RPCGN (crescents in greater than 70% of glomeruli), primary in 6 and associated with systemic diseases in 4, were treated with PE, associated with oral steroids (P) and cyclophosphamide (C) in all cases and with intravenous methylprednisolone pulses (MP) in 7 cases. Four out of ten patients were anuric and needed dialysis treatment at the start of treatment. Therapeutic benefit, i.e. reversal of the trend to further deterioration and substantial improvement of GFR, was achieved in 8 out of 10 patients (80%), including 2 of 4 anuric patients, and in 7 of those (8) who had still active cellular crescents (87.5%). Similar therapeutic benefit had been achieved only in 10% of a comparable population of 10 patients with RPCGN treated before 1980 with P and C, without PE or MP pulses. It is difficult to establish whether the better therapeutic results in the more recently treated group were due to PE or to MP pulses of to both the new approaches, even though the clinical improvement obtained in all the 3 patients treated with PE without concomitant MP suggest a specific beneficial role for PE. RPCGN is a catastrophic illness characterized by progressive deterioration of kidney function, resulting in oliguria and uremia, usually within weeks or months. The most consistent histopathologic finding is the presence of extensive glomerular crescents resulting from proliferation of the extracapillary epithelial cell lining of Bowman's capsule. It is apparent that RPCGN is not a homogeneous entity, clinically, histologically or immunohistologically, but rather a clinicopathologic syndrome, the features of which may be seen in a variety of systemic disorders, including SLE, polyarteritis nodosa, Wegener's granulomatosis, Henoch-Schönlein purpura, cryoglobulinemia, and subacute bacterial endocarditis.(ABSTRACT TRUNCATED AT 250 WORDS)

  2. Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents.

    Science.gov (United States)

    Avasare, Rupali S; Rosenstiel, Paul E; Zaky, Ziad S; Tsapepas, Demetra S; Appel, Gerald B; Markowitz, Glen S; Bomback, Andrew S; Canetta, Pietro A

    2017-01-01

    Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to recurrent IgAN. Secondary outcomes were a composite of doubling of creatinine or allograft failure, and recurrent IgAN as a cause of allograft dysfunction. Of the 62 patients, 14 had recurrent IgAN in the allograft. Mean time to recurrence was 2.75 years. Those with recurrent disease were younger at the time of native kidney biopsy (29 vs. 41 years, p < 0.0009). Black race and Hispanic ethnicity composed a higher proportion of the recurrent disease group. On multivariable analysis, significant predictors of recurrent IgAN included age at diagnosis (hazards ratio (HR) 0.911, 95% CI 0.85-0.98), burden of crescents on native biopsy (HR 1.21 per 10% increase in crescents, 95% CI 1.00-1.47) and allograft rejection (HR 3.59, 95% CI 1.10-11.7). Features of native IgAN can help predict the risk of recurrent disease in the renal allograft. In particular, immunologically active disease represented by earlier age of onset and greater burden of crescents on native biopsy is more likely to recur after transplant. © 2017 S. Karger AG, Basel.

  3. Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Succar L

    2016-11-01

    Full Text Available Lena Succar,1 Ross A Boadle,2 David C Harris,1,3 Gopala K Rangan1,3 1Centre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, 2Electron Microscopy Laboratory, Institute of Clinical Pathology and Medical Research, Westmead Hospital, 3Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Westmead, Sydney, NSW, Australia Purpose: In crescentic glomerulonephritis (CGN, the development of cellular bridges between podocytes and parietal epithelial cells (PECs triggers glomerular crescent formation. However, the sequential changes in glomerular ultrastructure in CGN are not well defined. This study investigated the time course of glomerular ultrastructure in experimental CGN. Methods: Transmission electron microscopy (TEM was performed using kidney samples from rats with nephrotoxic serum nephritis (NSN from day 1 to day 14. Morphometric analysis was conducted on randomly selected glomeruli captured on TEM digital images. Results: On day 1 of NSN, there was widespread formation of focal contacts between the cell bodies of neighboring podocytes, and tight junctions were evident at the site of cell-to-cell contact. This was confirmed by the increased expression of the tight junction molecule, zonula occludens-1 (ZO-1, which localized to the points of podocyte cell–cell body contact. On day 2, the interpodocyte distance decreased and the glomerular basement membrane thickness increased. Foot process effacement (FPE was segmental on day 3 and diffuse by day 5, accompanied by the formation of podocyte cellular bridges with Bowman’s capsule, as confirmed by a decrease in podocyte-to-PEC distance. Fibrinoid necrosis and cellular crescents were evident in all glomeruli by days 7 and 14. In vitro, the exposure of podocytes to macrophage-conditioned media altered cellular morphology and caused an intracellular redistribution of ZO-1. Conclusion: The formation of tight

  4. Crescent shaped Fabry-Perot fiber cavity for ultra-sensitive strain measurement

    Science.gov (United States)

    Liu, Ye; Wang, D. N.; Chen, W. P.

    2016-12-01

    Optical Fabry-Perot interferometer sensors based on inner air-cavity is featured with compact size, good robustness and high strain sensitivity, especially when an ultra-thin air-cavity is adopted. The typical shape of Fabry-Perot inner air-cavity with reflection mode of operation is elliptic, with minor axis along with and major axis perpendicular to the fiber length. The first reflection surface is diverging whereas the second one is converging. To increase the visibility of the output interference pattern, the length of major axis should be large for a given cavity length. However, the largest value of the major axis is limited by the optical fiber diameter. If the major axis length reaches the fiber diameter, the robustness of the Fabry-Perot cavity device would be decreased. Here we demonstrate an ultra-thin crescent shaped Fabry-Perot cavity for strain sensing with ultra-high sensitivity and low temperature cross-sensitivity. The crescent-shape cavity consists of two converging reflection surfaces, which provide the advantages of enhanced strain sensitivity when compared with elliptic or D-shaped FP cavity. The device is fabricated by fusion splicing an etched multimode fiber with a single mode fiber, and hence is simple in structure and economic in cost.

  5. Urinary Transforming Growth Factor-beta 1 as a marker of response to immunosuppressive treatment, in patients with crescentic nephritis

    Directory of Open Access Journals (Sweden)

    Sotsiou Florentia

    2005-12-01

    Full Text Available Abstract Background Crescentic nephritis is characterized by formation of cellular crescents that soon become fibrotic and result in irreversible damage, unless an effective immunosuppressive therapy is rapidly commenced. TGF-β1 is involved in the development of crescents through various pathways. The aim of this study was to identify whether the determination of urinary TGF-β1 levels in patients with crescentic nephritis could be used as a marker of response to treatment. Methods Fifteen patients with crescentic nephritis were included in the study. The renal expression of TGF-β1 was estimated in biopsy sections by immunohistochemistry and urinary TGF-β1 levels were determined by quantitative sandwich enzyme immunoassay (EIA. TGF-β1 levels were determined at the time of renal biopsy, before the initiation of immunosuppressive treatment (corticosteroids, cyclophosphamide and plasma exchange. Twelve patients with other types of proliferative glomerulonephritis and ten healthy subjects were used as controls. Results Improvement of renal function with immunosuppressive therapy was observed in 6 and stabilization in 4 patients (serum creatinine from 3.2 ± 1.5 to 1.4 ± 0.1 mg/dl and from 4.4 ± 1.2 to 4.1 ± 0.6 mg/dl, respectively. In 5 patients, with severe impairment of renal function who started on dialysis, no improvement was noted. The main histological feature differentiating these 5 patients from others with improved or stabilized renal function was the percentage patients with poor response to treatment were the percentage of glomeruli with crescents and the presence of ruptured Bowman's capsule and glomerular necrosis. Urinary TGF-β1 levels were significantly higher in patients who showed no improvement of renal function with immunosuppressive therapy (930 ± 126 ng/24 h vs. 376 ± 84 ng/24 h, p 1 was identified in crescents and tubular epithelial cells, whereas a significant correlation of TGF-β1 immunostaining with the presence

  6. Clinical features and outcomes of ANCA-associated renal vasculitis

    Directory of Open Access Journals (Sweden)

    Sidy Mohamed Seck

    2012-01-01

    Full Text Available To determine the patterns and outcomes of the pauci-immune vasculitis in the nephrology department at hospital La Conception in Marseille, we conducted a retrospective study including all patients with diagnosis of pauci-immune renal vasculitis between January 1, 2000 and December 31, 2007. Among 33 cases, 25 were diagnosed as Wegener granulomatosis (WG, seven as microscopic polyangitis (MPA and one as Churg-Strauss syndrome (SCS. The median age of the patients was 57.7 years and the sex-ratio (M/F was 1.6. The visceral mani-festations included kidneys (100% of patients, lungs (75%, ENT (52% of WG, and nervous system (57% of MPA. The mean serum creatinine at admission was 3.3 mg/dL. Renal biopsies revealed a pauci-immune crescentic gromerulonephritis in 96% of the cases. Two patients with WG received plasmapheresis and seven patients required emergency hemodialysis. Induction therapy comprised cyclophosphamide IV and corticosteroids, while maintenance therapy included azathioprine for the majority of patients. Eighty four percent of the patients experienced complete remission after induction therapy. During maintenance therapy relapses were more frequent among patients with MPA (28% compared to WG cases (12%. After 35 months of follow-up, eight patients ended on chronic hemodialysis, and five patients died. ANCA associated vasculitis are frequent in our patients. Long-term outcomes are relatively good despite a mortality rate of 15% and 25% of the patients entering dialysis after three years of follow-up.

  7. The bony crescent sign - a new sign of facial nerve schwannoma

    International Nuclear Information System (INIS)

    Watts, A.; Fagan, P.

    1992-01-01

    Schwannomas are relatively uncommon intracranial tumours. They most commonly involve the acoustic nerve followed in frequency by the trigeminal nerve. Other cranial nerves are rarely involved. Facial nerve schwannomas occurring within the petrous temporal bone are very rare. Their diagnosis may be missed prospectively even when appropriate computerized tomography (CT) scans are performed. Even in retrospect the site of abnormality may be difficult to identify, especially if there is an associated middle ear mass such as a cholesteatoma. In the 4 cases presented the facial nerve schwannoma was seen on high resolution CT as a soft tissue mass bounded anteriorly by a thin rim of bone. This bony crescent sign is a previously undescribed feature of facial nerve schwannoma which appears to be strongly indicative of the presence of this tumour. Recognition of this sign makes these tumours arising in the region of the geniculate ganglion easy to diagnose prospectively. 12 refs., 6 figs

  8. Investigating of Relationship between Conflict and Trust on the Golestan Province Red Crescent Society Volunteer Groups

    Directory of Open Access Journals (Sweden)

    Seidmehdi Mehdi Veiseh

    2014-06-01

    Full Text Available Conflict is the most important behavioral issues that, in several last deceed organizational behavior scholars intentioned to it .according to several idea about positive effects of management of conflict in organization relationship between conflict and many variables had been surveyed .in this research relationship between conflict and trust was surveyed. According to this, researchers studied the theatrical basic of research correctly and recognized main component s and variables by descriptive-survey method in this research and selected sample by random sampling and surveyed research assumptions in Golestan Red Crescent organization. Results of research shows that task conflict related with intergroup trust directly, also there is any relationship between relationship conflict and trust. Finally task conflict related with relationship conflict directly

  9. Generation of highly confined photonic nanojet using crescent-shape refractive index profile in microsphere

    Science.gov (United States)

    Patel, H. S.; Kushwaha, P. K.; Swami, M. K.

    2018-05-01

    Photonic nanojets (PNJs) owing to their sub-wavelength near-field features have found many interesting applications like nanoscopy, nano photolithography, high density optical storage, enhancement of Raman signal and single molecule spectroscopy etc. More recently, the focus of research has been on tailoring of PNJs either for better confinement and thus higher peak intensity or for elongation of nanojet for high resolution far field applications. In this paper, we show that crescent-shape refractive index profile (CSRP) of microspheres can be used to generate highly confined PNJ. By optimizing the refractive index of different layers in CSRP microsphere, we show a free space confinement down to ∼ λ / 4 . 5 (FWHM ∼ 110 nm for excitation with 500 nm wavelength). Further, it was observed that the optical properties of substrates also modulate the PNJ characteristics and lead to a further improvement in the transverse confinement to ∼ λ / 6 . 7.

  10. 76 FR 60475 - Issuance of a Loan Guarantee to Tonopah Solar Energy, LLC, for the Crescent Dunes Solar Energy...

    Science.gov (United States)

    2011-09-29

    ... DEPARTMENT OF ENERGY Issuance of a Loan Guarantee to Tonopah Solar Energy, LLC, for the Crescent Dunes Solar Energy Project AGENCY: U.S. Department of Energy. ACTION: Record of decision. SUMMARY: The U... and Reinvestment Act of 2009 (Recovery Act), to Tonopah Solar Energy, LLC (TSE), for construction and...

  11. Wild relatives of domesticated pea in the Mediterranean Region and the Fertile Crescent will respond to global climate change

    Science.gov (United States)

    There is growing interest in conservation and utilization of crop wild relatives (CWR) in international food security policy and research. We explored macroecological patterns of wild pea in the Mediterranean Basin and the Fertile Crescent in relation to the past, current and future climate suitabil...

  12. C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases

    Directory of Open Access Journals (Sweden)

    Ruchika Gupta

    2015-01-01

    Full Text Available C1q nephropathy is a recently described clinico-pathologic entity with a variable clinical presentation and pathology. Crescentic glomerulonephritis (GN has been reported in only two patients in the available literature. CD59 deficiency, along with lack of CD55, is responsible for paroxysmal nocturnal hemoglobinuria (PNH. Few cases of isolated CD59 deficiency have been described with PNH-like features. A middle-aged adult male presented with rapidly progressive renal failure. Serological investigations were negative. A renal biopsy revealed necrotizing crescentic GN with rupture of Bowman′s capsule. Immunofluorescence on the frozen sections showed dominant mesangial deposits of C1q along with IgM. Hematological work-up of the patient revealed isolated CD59 deficiency. Hence, a final diagnosis of C1q nephropathy and CD59 deficiency manifesting as crescentic GN and hemolytic anemia was made. The co-existence of two rare disorders, C1q nephropathy and CD59 deficiency, in a patient with necrotizing crescentic GN is described for the first time to the best of our knowledge. The pathogenetic link of these two entities with the clinical manifestation requires further study.

  13. Meningitis granulomatosa, glomerulonefritis rápidamente progresiva y vasculitis Granulomatous meningitis, crescentic glomerulonephritis and vasculitis

    Directory of Open Access Journals (Sweden)

    Ana Ludueña

    2011-08-01

    Full Text Available El compromiso meníngeo es una manifestación infrecuente de la granulomatosis de Wegener. Puede manifestarse como cefalea con hiperproteinorraquia y engrosamiento de la duramadre con aspecto granulomatoso, que se observa en la resonancia magnética. Presentamos un varón de 57 años con granulomatosis de Wegener que debutó con compromiso de vías aéreas superiores, oídos, órbitas y meningitis granulomatosa asintomática y que posteriormente evolucionó con mononeuritis múltiple y glomerulonefritis crescéntica ANCA positiva. La presencia de ANCA y el compromiso sistémico (vías aéreas superiores, oído, órbitas, nervios periféricos, duramadre y glomerulonefritis rápidamente progresiva permitieron en este caso llegar a un diagnóstico de certeza e iniciar el tratamiento inmunosupresor combinado (corticoides y ciclofosfamida. Evolucionó con remisión clínica y serológica (negativización de ANCA, pero persistiendo leve deterioro secuelar auditivo y de la función renal, sin recidiva de la enfermedad de base.Meningeal involvement is an infrequent manifestation of Wegener's granulomatosis. Clinical manifestations can be headache with high protein level in the cerebrospinal fluid and an enhanced MRI signal of granulomatous thickening of the duramater in the brain. We report a 57 year-old male with Wegener granulomatosis with onset manifestations of asymptomatic granulomatous meningitis, upper respiratory tract, ears and orbits involvement. He progressively developed ANCA positive multiple mononeuritis and crescentic glomerulonephritis. The diagnostic confirmation of Wegener's granulomatosis based on a positive ANCA test and on the evidence of systemic disease (crescentic glomerulonephritis and involvement of the upper respiratory tract, ears, orbits, peripheral nerves and duramater allowed a prompt initiation of aggressive immunosuppressive treatment with systemic cyclophosphamide and high - dosis corticosteroids. The patient entered

  14. Rhino-orbitocerebral mucormycosis in a patient with idiopathic crescentic glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Suzan Sanavi

    2013-01-01

    Full Text Available Mucormycosis, caused by mucorales, is an acute, rapidly progressive infection associated with high mortality. Rhino-orbitocerebral infection is the most common variant and is generally seen in association with immune deficiency syndromes. Prompt medical treatment of this infection and debridement decreases the mortality rate. We describe a 47-year-old man with crescentic glomerulonephritis on maintenance prednisolone therapy. He had earlier received steroid and cyclophosphamide pulse therapies. Renal functions improved following immunosuppressive treatment. In the third month of maintenance therapy, he presented to us with left-sided facial swelling and bloody nasal discharge. He had high blood sugar and acidic blood pH (ketoacidosis, probably due to steroid therapy. Magnetic resonance imaging of the head and sinuses showed inflammation and mass in the ethmoid sinus and nose with partial septal destruction, proptosis, global destruction of the left eye, brain infarction and carotid artery obliteration. Endoscopic biopsy of the sinuses revealed severe tissue necrosis. Samples of nasal discharge and biopsy tissue showed aseptate hyphae on light microscopy and culture, compatible with Rhizopus. The patient was treated with amphotericin B and multiple wound debridements along with ethmoidectomy and enucleation of the left eye. He was discharged in good general condition but with mild right hemiparesis. On follow-up examination at one year, there were no signs of fungal infection or renal dysfunction.

  15. Open wedge metatarsal osteotomy versus crescentic osteotomy to correct severe hallux valgus deformity

    DEFF Research Database (Denmark)

    Wester, Jens Ulrik; Hamborg-Petersen, Ellen; Herold, Niels

    2016-01-01

    BACKGROUND: Different techniques of proximal osteotomies have been introduced to correct severe hallux valgus. The open wedge osteotomy is a newly introduced method for proximal osteotomy. The aim of this prospective randomized study was to compare the radiological and clinical results after...... operation for severe hallux valgus, comparing the open wedge osteotomy to the crescentic osteotomy which is our traditional treatment. METHODS: Forty-five patients with severe hallux valgus (hallux valgus angle >35̊, and intermetatarsal angle >15̊) were included in this study. The treatment was proximal...... and 12 months after the operation. RESULTS: In group 1 the hallux valgus angle decreased from 39.0̊ to 24.1̊ after 4 months and 27.9̊ after 12 months. In group 2 the angle decreased from 38.3̊ to 21.4̊ after 4 months and 27.0̊ after 12 months. The intermetatarsal angle in group 1 was 19.0̊ preoperatively...

  16. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORINGS_CRESCENT_64W_32N and MOORING_CRESCENT_64W_32N in the North Atlantic Ocean from 2010-11-27 to 2015-12-31 (NODC Accession 0117059)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0117059 includes chemical, meteorological, physical and time series data collected from MOORINGS_CRESCENT_64W_32N and MOORING_CRESCENT_64W_32N in the...

  17. Crescentic and ring-shaped opacities. CT features in two cases of bronchiolitis obliterans organizing pneumonia (BOOP)

    International Nuclear Information System (INIS)

    Voloudaki, A.E.; Bouros, D.E.; Froudarakis, M.E.; Datseris, G.E.; Apostolaki, E.G.; Gourtsoyiannis, N.C.

    1996-01-01

    Two cases of idiopathic bronchilitis obliterans organizing pneumonia (BOOP) with unusual CT findings are presented. On CT both cases exhibited crescentic and ring-shaped opacities, surrounding areas of groundglass attenuation, and associated with a nodular pattern in one patient and airspace consolidations in the second patient. CT-pathologic correlation dislosed that the central areas of groundglass attenuation corresponded to alveolar septal inflammation, in contrast to the denser periphery where granulomatous tissue in peripheral airspaces predominated. In the broad spectrum of CT findings, BOOP can exhibit specific CT features with regard to the crescentic or ring-shaped opacities with a central groundglass attenuation area. Since these features have not been described in any other disease, they might be characteristic features for the diagnosis of BOOP. (orig.)

  18. Trafficking Golden Crescent Drugs into Western China: An Analysis and Translation of a Recent Chinese Police Research Article

    Science.gov (United States)

    2011-01-01

    illegal drug exchanges and consumption markets in Xinjiang, and soon this heroin even exceeded the market position of traditional Golden Triangle heroin...tons of the precursor chemical acetic anhydride {cusucmgan; WiW. iff) being smuggled out of the border. • 800,000 tabs of the psychoactive drug ...Trafficking Golden Crescent Drugs into Western China: An Analysis and Translation of a Recent Chinese Police Research Article Dr. Murray Scot

  19. Monitoring plant tissue nitrogen isotopes to assess nearshore inputs of nitrogen to Lake Crescent, Olympic National Park, Washington

    Science.gov (United States)

    Cox, Stephen E.; Moran, Patrick W.; Huffman, Raegan L.; Fradkin, Steven C.

    2016-05-31

    Mats of filamentous-periphytic algae present in some nearshore areas of Lake Crescent, Olympic National Park, Washington, may indicate early stages of eutrophication from nutrient enrichment of an otherwise highly oligotrophic lake. Natural abundance ratios of stable isotopes of nitrogen (δ15N) measured in plant tissue growing in nearshore areas of the lake indicate that the major source of nitrogen used by these primary producing plants is derived mainly from atmospherically fixed nitrogen in an undeveloped forested ecosystem. Exceptions to this pattern occurred in the Barnes Point area where elevated δ15N ratios indicate that effluent from septic systems also contribute nitrogen to filamentous-periphytic algae growing in the littoral zone of that area. Near the Lyre River outlet of Lake Crescent, the δ15N of filamentous-periphytic algae growing in close proximity to the spawning areas of a unique species of trout show little evidence of elevated δ15N indicating that nitrogen from on-site septic systems is not a substantial source of nitrogen for these plants. The δ15N data corroborate estimates that nitrogen input to Lake Crescent from septic sources is comparatively small relative to input from motor vehicle exhaust and vegetative sources in undeveloped forests, including litterfall, pollen, and symbiotic nitrogen fixation. The seasonal timing of blooms of filamentous-periphytic algal near the lake shoreline is also consistent with nitrogen exported from stands of red alder trees (Alnus rubra). Isotope biomonitoring of filamentous-periphytic algae may be an effective approach to monitoring the littoral zone for nutrient input to Lake Crescent from septic sources.

  20. [Notes on the Indian Red Crescent aid and Dr. Ensari's contributions before the decline of the Ottoman Empire].

    Science.gov (United States)

    Izgöer, Ahmet Zeki

    2002-01-01

    This article deals with the Indian Red Crescent aids and Dr. Ahmed Ensari's role in this activity during the wars in the early 20th century that led the Ottoman Empire to dismantle. The Indian Red Crescent presided by Dr. Ensari sent a medical team and sanitary material for the Ottomans battered during the war in Tripoli (1911) and the succeeding war at the Balkans (1912). The article also deals with the meetings of the above-mentioned medical team with the Ottoman statesmen and dignitaries; its success at the Tripoli front and its projects concerning the Ottoman immigrants from the Balkan region. The humanitarian aids of the Indian Red Crescent continued afterwards, especially during the World War II (1914-1918) and the War of Independence (1919-1922). On their return to India, Dr. Ensari and the members of the team held a series of meetings and spoke of their activities to the people in their country. They tried to spread their sympathy for the Ottoman-Turkish people even to the outposts of India. This article is an attempt to describe the sympathy of this brother nation (Pakistan of today) proved by their aids and support far away from their borders.

  1. Long Term Population, City Size and Climate Trends in the Fertile Crescent: A First Approximation.

    Science.gov (United States)

    Lawrence, Dan; Philip, Graham; Hunt, Hannah; Snape-Kennedy, Lisa; Wilkinson, T J

    2016-01-01

    Over the last 8000 years the Fertile Crescent of the Near East has seen the emergence of urban agglomerations, small scale polities and large territorial empires, all of which had profound effects on settlement patterns. Computational approaches, including the use of remote sensing data, allow us to analyse these changes at unprecedented geographical and temporal scales. Here we employ these techniques to examine and compare long term trends in urbanisation, population and climate records. Maximum city size is used as a proxy for the intensity of urbanisation, whilst population trends are modelled from settlement densities in nine archaeological surveys conducted over the last 30 years across the region. These two measures are then compared with atmospheric moisture levels derived from multiple proxy analyses from two locations close to the study area, Soreq Cave in Israel and Lake Van in south-eastern Turkey, as well as wider literature. The earliest urban sites emerged during a period of relatively high atmospheric moisture levels and conform to a series of size thresholds. However, after the Early Bronze Age maximum urban size and population levels increase rapidly whilst atmospheric moisture declines. We argue that although the initial phase of urbanization may have been linked to climate conditions, we can see a definitive decoupling of climate and settlement patterns after 2000 BC. We relate this phenomenon to changes in socio-economic organisation and integration in large territorial empires. The complex relationships sustaining urban growth during this later period resulted in an increase in system fragility and ultimately impacted on the sustainability of cities in the long term.

  2. Traditional flat breads spread from the Fertile Crescent: Production process and history of baking systems

    Directory of Open Access Journals (Sweden)

    Antonella Pasqualone

    2018-03-01

    Full Text Available The “flat” breads include a multitude of bread types different from each other but are always relatively thin, ranging from a few millimeters to a few centimeters in thickness. These breads, whose origin is very ancient, fit well into the context of a subsistence economy: i they can be obtained from cereals other than wheat, such as pseudocereals or legumes, allowing the use of sustainable local productions from marginal lands; ii they do not necessarily require an oven to be baked; iii they can serve as a dish and as a spoon/fork; iv they can be dehydrated by a second baking process, preventing the growth of molds and extending the shelf life; v they are transported with little encumbrance. These strong points make flat breads very popular, traditionally in Near East and Central Asia and also in some Mediterranean areas, in the Arabian Peninsula, and in the Indian subcontinent. By a multidisciplinary approach, this review gives an insight into the variety of traditional flat breads from the Fertile Crescent and related regions, classifying them on the basis of their production process. Moreover, the baking systems adopted to prepare flat breads are reviewed, such as vertical ovens (tannur and tabun and griddles (saj, whose structure, origin, history, and values are described in detail. This overview shows that these breads have survived until today because of their versatility. In fact, flat breads can be produced both in the same way as they were made thousands of years ago and in modern fully automatic industrial lines, allowing tradition to meet innovation. Keywords: Flat bread, Pancake-like bread, saj, tannur, Vertical oven

  3. A Lagrangian analysis of the moisture budget over the Fertile Crescent during two intense drought episodes

    Science.gov (United States)

    Salah, Zeinab; Nieto, Raquel; Drumond, Anita; Gimeno, Luis; Vicente-Serrano, Sergio M.

    2018-05-01

    The Fertile Crescent (FC) region comprises the east coast of the Mediterranean Sea and the northern part of the Arabian Peninsula. The FC suffered two severe drought episodes separated by a 7-year period, in 1998-2000 and 2007-2009, which are considered the most severe episodes to hit the region in the last 50 years. A Lagrangian model (FLEXPART) and ERA-Interim data (with a 1° × 1° lat-long resolution) were used to identify for the first time the climatological sources of moisture for the FC and their characteristics. Variability and the source-receptor relationships, concerning their contribution to the precipitation, and the implications regarding the transport of moisture changes over the FC, during the wet season (October-May) from 1980 to 2014 were analysed. The main climatological moisture sources during this period were determined to be the FC itself, the eastern Mediterranean Sea, the Red Sea, the Persian Gulf, the Arabian Sea, the Caspian and Black Seas, and the central and western parts of the Mediterranean Sea. The analysis showed higher anomalous conditions in the moisture transport from some moisture sources during the two outstanding drought episodes. The key feature of the wet seasons during these episodes was a deficit in the moisture losses over the studied area related to the FC itself, the Red and Arabian Seas sources, followed and to a lesser extent by the eastern Mediterranean Sea over the northern part of the FC region. Nevertheless, the moisture supply deficit from the sources was much greater during the 2007-2009 drought event. The SPEI index at large scales (24 months) showed that the 2007-2009 episode was part of longer-term drought conditions that had been developing over the previous months, reinforcing the drought severity given recycling processes attributed to the FC. During the two extreme drought episodes, the mountainous terrain over the northern and eastern FC suffered the highest precipitation deficits, and these areas are

  4. Radiographic/morphologic investigation of a radiolucent crescent within the flexor central eminence of the navicular bone in Thoroughbreds

    International Nuclear Information System (INIS)

    Berry, C.R.; Pool, R.R.; Stover, S.; O'Brien, T.R.; Koblik, P.D.

    1992-01-01

    The source of a previously described radiolucent crescent in the flexor cortex of the distal sesamoid (navicular) bone on the palmaro45 degrees proximal-palmarodistal oblique (Pa45 degrees Pr-PaDio) clinical radiographic projection was investigated in 48 forelimb navicular bones from 24 Thoroughbreds by use of high-detail radiography and x-ray computed tomography (CT). Twenty-five of these bones also were evaluated, using microradiography and histologic examinations. Of these 25 bones, 5 had been labeled in vivo with fluorochrome markers. Tetrachrome-stained 100-microns-thick nondecalcified sections of these 5 bones were examined, using epifluorescence microscopy. A reinforcement line of compacted cancellous bone, parallel and several millimeters deep to the flexor cortex in the region of the flexor central eminence, was visualized by CT in 42 of 48 navicular bones and by microradiography in 23 of 25 navicular bones investigated. Variable degrees of compaction were observed in the cancellous bone between the flexor cortex and the reinforcement line. High-detail skyline radiographic projections and reconstructed CT images indicated a crescent-shaped lucency within the flexor central eminence of the flexor cortex in the bones in which the reinforcement line was identified, but the cancellous bone between the reinforcement line and the flexor cortex had not been compacted. The radiolucent crescent seen in the flexor central eminence of the navicular bone on the Pa45 degrees Pr-PaDiO projection was not caused by the concave defect or synovial fossa of the flexor central eminence overlying the flexor cortex, as was described

  5. Sources and sinks of nitrogen and phosphorus to a deep, oligotrophic lake, Lake Crescent, Olympic National Park, Washington

    Science.gov (United States)

    Moran, P.W.; Cox, S.E.; Embrey, S.S.; Huffman, R.L.; Olsen, T.D.; Fradkin, S.C.

    2012-01-01

    Lake Crescent, in Olympic National Park in the northwest corner of Washington State is a deep-water lake renowned for its pristine water quality and oligotrophic nature. To examine the major sources and sinks of nutrients (as total nitrogen, total phosphorus, and dissolved nitrate), a study was conducted in the Lake Crescent watershed. The study involved measuring five major inflow streams, the Lyre River as the major outflow, recording weather and climatic data, coring lake bed sediment, and analyzing nutrient chemistry in several relevant media over 14 months. Water samples for total nitrogen, total phosphorous, and dissolved nitrate from the five inflow streams, the outlet Lyre River, and two stations in the lake were collected monthly from May 2006 through May 2007. Periodic samples of shallow water from temporary sampling wells were collected at numerous locations around the lake. Concentrations of nutrients detected in Lake Crescent and tributaries were then applied to the water budget estimates to arrive at monthly and annual loads from various environmental components within the watershed. Other sources, such as leaf litter, pollen, or automobile exhaust were estimated from annual values obtained from various literature sources. This information then was used to construct a nutrient budget for total nitrogen and total phosphorus. The nitrogen budget generally highlights vehicle traffic-diesel trucks in particular-along U.S. Highway 101 as a potential major anthropogenic source of nitrogen compounds in the lake. In contrast, contribution of nitrogen compounds from onsite septic systems appears to be relatively minor related to the other sources identified.

  6. High performance 1.3 μm buried crescent lasers and LEDs for fiber optic links

    International Nuclear Information System (INIS)

    Fu, R.J.; Chan, E.Y.; Hong, C.S.

    1989-01-01

    Self-aligned buried crescent heterostructure (BCH) semiconductor lasers and LEDs have been successfully developed as superb light sources for fiber optic communications. The fabrication and performance characteristics of these InGaAsP/InP lasers and LEDs are described. For lasers, the threshold currents as low as 10 mA and differential quantum efficiencies as high as 50% are achieved. For LEDs, the output powers at 150 mA are higher than 1 mW. Good far field patterns are obtained in both the LEDs and lasers. Measured I-V, L-I, spectrum and far field patterns are presented

  7. Open wedge metatarsal osteotomy versus crescentic osteotomy to correct severe hallux valgus deformity - A prospective comparative study.

    Science.gov (United States)

    Wester, Jens Ulrik; Hamborg-Petersen, Ellen; Herold, Niels; Hansen, Palle Bo; Froekjaer, Johnny

    2016-03-01

    Different techniques of proximal osteotomies have been introduced to correct severe hallux valgus. The open wedge osteotomy is a newly introduced method for proximal osteotomy. The aim of this prospective randomized study was to compare the radiological and clinical results after operation for severe hallux valgus, comparing the open wedge osteotomy to the crescentic osteotomy which is our traditional treatment. Forty-five patients with severe hallux valgus (hallux valgus angle >35̊, and intermetatarsal angle >15̊) were included in this study. The treatment was proximal open wedge osteotomy and fixation with plate (Hemax), group 1, or operation with proximal crescentic osteotomy and fixation with a 3mm cannulated screw, group 2. The mean age was 52 years (19-71). Forty-one females and four males were included. Clinical and radiological follow-ups were performed 4 and 12 months after the operation. In group 1 the hallux valgus angle decreased from 39.0̊ to 24.1̊ after 4 months and 27.9̊ after 12 months. In group 2 the angle decreased from 38.3̊ to 21.4̊ after 4 months and 27.0̊ after 12 months. The intermetatarsal angle in group 1 was 19.0̊ preoperatively, 11.6̊ after 4 months and 12.6̊ after 12 months. In group 2 the mean intermetatarsal angle was 18.9̊ preoperatively, 12.0̊ after 4 months and 12.6̊ after 12 months. The AOFAS score improved from 59.3 to 81.5 in group 1 and from 61.8 to 84.8 in group 2 respectively measured 12 months postoperatively. The relative length of the 1 metatarsal compared to 2 metatarsal bone was 0.88 and 0.87 preoperatively and 0.88 and 0.86 for group 1 and 2 respectively measured after 12 months. Crescentic osteotomy and open wedge osteotomy improve AOFAS score and VAS scores on patients operated with severe hallux valgus. No significant difference was found in the two groups looking at the postoperative improvement of HVA and IMA measured 4 and 12 months postoperatively. The postoperative VAS score and AOFAS score were

  8. Participacao crescente de produtos ultraprocessados na dieta brasileira (1987-2009

    Directory of Open Access Journals (Sweden)

    Ana Paula Bortoletto Martins

    2013-08-01

    ários. CONCLUSÕES Produtos ultraprocessados apresentam participação crescente na dieta brasileira, evidenciada desde a década de 1980 nas áreas metropolitanas e confirmada para todo o País na década de 2000.

  9. Respostas de cultivares de girassol a doses crescentes de boro na entressafra do Cerrado Tocantinense

    Directory of Open Access Journals (Sweden)

    A. Capone

    2016-01-01

    Full Text Available No cerrado brasileiro a deficiência de boro no solo ocorre com maior frequência. A cultura do girassol é muito sensível à deficiência deste micronutriente, além de apresentar pouca eficiência em seu aproveitamento. Neste contexto, objetivou-se com este estudo avaliar as respostas de cultivares de girassol a doses crescentes de boro no período da entressafra no cerrado tocantinense. O experimento foi conduzido em Gurupi, (TO, com sistema de plantio direto em sucessão a soja, sobre Latossolo Vermelho Amarelo distrófico. O delineamento experimental utilizado foi de blocos casualizados, com quinze tratamentos e quatro repetições. Os tratamentos foram dispostos num esquema fatorial simples 3 x 5, constituído por três cultivares de girassol (variedade Br 122, híbridos Aguará 4 e Helio 863 e cinco doses de ácido bórico (0, 1, 2, 3 e 4 kg ha-1. As características avaliadas foram: altura de planta, diâmetro da haste, diâmetro do capítulo, concentração de boro foliar, massa de mil aquênios e produtividade de aquênios. A dose de 3 kg ha-1 de boro proporcionou, em sua grande maioria, as melhores respostas das cultivares Br 122, Aguará 4 e Helio 863 quanto às características avaliadas. No entanto, com esta dose, a cultivar Aguará 4 apresenta melhor aproveitamento para produção de aquênios.Responses of sunflower cultivars to increasing doses of boron in the between harvests the Cerrado TocantinenseAbstract: In the brazilian cerrado soil boron deficiency occurs more frequently. The sunflower crop is very sensitive to this micronutrient deficiency, and have little efficiency in its use. In that context, aimed to of this study was to evaluate the response of sunflower cultivars to increasing doses of boron during the between harvests in the cerrado tocantinense. The experiment was conducted in Gurupi (TO, with no-tillages soybeans in succession on dystrophic Red Yellow Latosol. The experimental design was a randomized block

  10. A Probabilistic Tsunami Hazard Assessment Methodology and Its Application to Crescent City, CA

    Science.gov (United States)

    Gonzalez, F. I.; Leveque, R. J.; Waagan, K.; Adams, L.; Lin, G.

    2012-12-01

    A PTHA methodology, based in large part on Probabilistic Seismic Hazard Assessment methods (e.g., Cornell, 1968; SSHAC, 1997; Geist and Parsons, 2005), was previously applied to Seaside, OR (Gonzalez, et al., 2009). This initial version of the method has been updated to include: a revised method to estimate tidal uncertainty; an improved method for generating stochastic realizations to estimate slip distribution uncertainty (Mai and Beroza, 2002; Blair, et al., 2011); additional near-field sources in the Cascadia Subduction Zone, based on the work of Goldfinger, et al. (2012); far-field sources in Japan, based on information updated since the 3 March 2011 Tohoku tsunami (Japan Earthquake Research Committee, 2011). The GeoClaw tsunami model (Berger, et. al, 2011) is used to simulate generation, propagation and inundation. We will discuss this revised PTHA methodology and the results of its application to Crescent City, CA. Berger, M.J., D. L. George, R. J. LeVeque, and K. T. Mandli, The GeoClaw software for depth-averaged flows with adaptive refinement, Adv. Water Res. 34 (2011), pp. 1195-1206. Blair, J.L., McCrory, P.A., Oppenheimer, D.H., and Waldhauser, F. (2011): A Geo-referenced 3D model of the Juan de Fuca Slab and associated seismicity: U.S. Geological Survey Data Series 633, v.1.0, available at http://pubs.usgs.gov/ds/633/. Cornell, C. A. (1968): Engineering seismic risk analysis, Bull. Seismol. Soc. Am., 58, 1583-1606. Geist, E. L., and T. Parsons (2005): Probabilistic Analysis of Tsunami Hazards, Nat. Hazards, 37 (3), 277-314. Goldfinger, C., Nelson, C.H., Morey, A.E., Johnson, J.E., Patton, J.R., Karabanov, E., Gutiérrez-Pastor, J., Eriksson, A.T., Gràcia, E., Dunhill, G., Enkin, R.J., Dallimore, A., and Vallier, T. (2012): Turbidite event history—Methods and implications for Holocene paleoseismicity of the Cascadia subduction zone: U.S. Geological Survey Professional Paper 1661-F, 170 p. (Available at http://pubs.usgs.gov/pp/pp1661f/). González, F

  11. A pilot project of an online cross-age tutoring program: crescent school virtual learning (vLearning).

    Science.gov (United States)

    Chow, Ronald

    2016-11-01

    Traditional classroom teaching is the standard of education. However, there may be some students who feel uncomfortable approaching their teachers and may feel more at ease if they ask for assistance from their peers. There are two types of student-to-student tutoring methods that are supplements to classroom learning: peer tutoring between same-age students and cross-age tutoring between different-age children. Cross-age tutoring programs in which the tutor is 2-3 years older than the tutee have been reported to be more effective than those between same-age students in promoting student responsibility, empowerment and academic performance. A pilot online cross-age tutoring program was launched in September 2014 at Crescent School. A new website was designed, created and implemented with the permission and regular monitoring of the Student Services faculty for the online program - Crescent School Virtual Learning (vLearning). The program was well received and will undergo evaluation in the future.

  12. CARR-CNS with crescent-shape moderator cell and sub-cooling helium jacket around cell

    International Nuclear Information System (INIS)

    Yu, Qingfeng; Feng, Quanke; Kawai, Takeshi; Cheng, Liang; Shen, Feng; Yuan, Luzheng

    2005-01-01

    The new type of the moderator cell was developed for the Cold Neutron Source (CNS) of the China Advanced Research Reactor (CARR) which is now constructing at the China Institute of Atomic Energy in Beijing. A crescent-shape moderator cell covered by the sub-cooling helium jacket is adopted. A crescent-shape would help to increase the volume of the moderator cell for corresponding it to the 4 cold neutron guide tubes, even if liquid hydrogen not liquid deuterium were used as a cold moderator. The sub-cooling helium jacket covering the moderator cell removes the nuclear heating of the outer shell wall of the cell. It contributes to reduce the void fraction of liquid hydrogen in the inner shell. Such a type of a moderator cell is suitable for the CNS with higher nuclear heating. The cold helium gas flows down firstly into the sub-cooling helium jacket and then flows up to the condenser. Therefore, the theory of the self-regulation for the thermo-siphon type of the CNS is also applicable

  13. Narrowing the harvest: Increasing sickle investment and the rise of domesticated cereal agriculture in the Fertile Crescent

    Science.gov (United States)

    Maeda, Osamu; Lucas, Leilani; Silva, Fabio; Tanno, Ken-Ichi; Fuller, Dorian Q.

    2016-08-01

    For the first time we integrate quantitative data on lithic sickles and archaeobotanical evidence for domestication and the evolution of plant economies from sites dated to the terminal Pleistocene and Early Holocene (ca. 12000-5000 cal. BCE) from throughout the Fertile Crescent region of Southwest Asia. We find a strong correlation in some regions, throughout the Levant, for increasing investment in sickles that tracks the evidence for increasing reliance on cereal crops, while evidence for morphological domestication in wheats (Triticum monococcum and Triticum dicoccum) and barley (Hordeum vulgare) was delayed in comparison to sickle use. These data indicate that while the co-increase of sickle blades and cereal crops support the protracted development of agricultural practice, sickles did not drive the initial stages of the domestication process but rather were a cultural adaptation to increasing reliance on cereals that were still undergoing selection for morphological change. For other regions, such as the Eastern Fertile Crescent and Cyprus such correlations are weaker or non-existent suggesting diverse cultural trajectories to cereal domestication. We conclude that sickles were an exaptation transferred to cereal harvesting and important in signalling a new cultural identity of "farmers". Furthermore, the protracted process of technological and agricultural evolution calls into question hypotheses that the transition to agriculture was caused by any particular climatic event.

  14. Strength analysis of CARR-CNS with crescent-shape moderator cell and helium sub-cooling jacket covering cell

    International Nuclear Information System (INIS)

    Yu Qingfeng; Feng Quanke; Kawai Takeshi; Shen Feng; Yuan Luzheng; Cheng Liang

    2005-01-01

    The new type of the moderator cell was developed for the cold neutron source (CNS) of the China Advanced Research Reactor (CARR) which is now being constructed at the China Institute of Atomic Energy in Beijing. A crescent-shape moderator cell covered by the helium sub-cooling jacket is adopted. The structure of the moderator cell is optimized by the stress FEM analysis. A crescent-shape would help to increase the volume of the moderator cell for fitting it to the four cold neutron guide tubes, even if liquid hydrogen, not liquid deuterium, was used as a cold moderator. The helium sub-cooling jacket covering the moderator cell removes the nuclear heating of the outer shell wall of the cell. It contributes to reduce the void fraction of liquid hydrogen in the outer shell of the moderator cell. Such a type of a moderator cell is suitable for the CNS with higher nuclear heating. The cold helium gas flows down first into the helium sub-cooling jacket and then flows up to the condenser. The theory of the self-regulation suitable to the thermo-siphon type of the CNS is also applicable and validated

  15. CARR-CNS with crescent-shape moderator cell and sub-cooling helium jacket surrounding cell

    International Nuclear Information System (INIS)

    Yu, Qingfeng; Feng, Quanke; Kawai, Takeshi; Shen, Feng; Yuan, Luzheng

    2005-01-01

    The new type of the moderator cell was developed for the Cold Neutron Source (CNS) of the China Advanced Research Reactor (CARR) which is now constructing at the China Institute of Atomic Energy in Beijing. A crescent-shape moderator cell covered by the sub-cooling helium jacket is adopted. A crescent-shape would help to increase the volume of the moderator cell for corresponding it to the 4 cold neutron guide tubes, even if liquid hydrogen not liquid deuterium were used as a cold moderator. The sub-cooling helium jacket covering the moderator cell removes the nuclear heating of the outer shell wall of the cell. It contributes to reduce the void fraction of liquid hydrogen in the inner shell. Such a type of a moderator cell is suitable for the CNS with higher nuclear heating. The cold helium gas flows down firstly into the sub-cooling helium jacket and then flows up to the condenser. Therefore, the theory of the self-regulation for the thermo-siphon type of the CNS is also applicable

  16. The crescent sign: dissociation of the polyethylene liner from a modular acetabular component in total hip arthroplasty

    International Nuclear Information System (INIS)

    White, S.P.; Blom, A.W.; Lee, M.; Smith, E.J.

    2005-01-01

    To study whether there was a common pattern of clinical symptoms, signs and radiographic features for the dissociation of the polyethylene liner from an acetabular component and to postulate reasons for these features. Retrospective study of notes and radiographs of cases of revision hip arthroplasty for polyethylene liner dissociation of the cementless Harris-Galante I porous-coated acetabular component (Zimmer Inc, Warsaw, IN) at the Avon Orthopaedic Centre, Bristol, UK and St. Mary's Hospital, Bristol, UK between 1995 and 2004. Patients were contacted to confirm preoperative symptoms. Nine cases of late polyethylene liner dissociation of this prosthesis have been revised in these institutions. All patients presented with a reduction in mobility, groin pain and limp. Eight patients reported an audible noise on hip movement. In all cases, radiographs showed radiolucency medial to the femoral neck in association with an eccentrically placed femoral head showing contact with the acetabular metal shell, which we have termed the ''crescent sign.'' There is a typical clinical presentation in this study. The diagnosis can be made from a single anteroposterior pelvic radiograph without the need for previous films for comparison, or the need for arthrography. Clinicians should look specifically for the crescent sign when an eccentrically placed femoral head has been noted, in order to differentiate the more unusual diagnosis of dissociation from that of polyethylene wear. Early revision surgery can prevent damage to the femoral head and metal acetabular shell, thus reducing the complexity of revision surgery. (orig.)

  17. Spacecraft observations of a Maxwell Demon coating the separatrix of asymmetric magnetic reconnection with crescent-shaped electron distributions

    Science.gov (United States)

    Egedal, J.; Le, A.; Daughton, W.; Wetherton, B.; Cassak, Pa; Chen, Lj; Lavraud, B.; Dorell, J.; Avanov, L.; Gershman, D.

    2016-10-01

    During asymmetric magnetic reconnection in the dayside magnetopause in situ spacecraft mea- surements show that electrons from the high density inflow penetrate some distance into the low density inflow. Supported by a kinetic simulation, we present a general derivation of an exclusion energy parameter, which provides a lower kinetic energy bound for an electron to jump across the reconnection region from one inflow region to the other. As by a Maxwell Demon, only high energy electrons are permitted to cross the inner reconnection region, strongly impacting the form of the electron distribution function observed along the low density side separatrix. The dynamics produce two distinct flavors of crescent-shaped electron distributions in a thin boundary layer along the separatrix between the magnetospheric inflow and the reconnection exhaust. The analytical model presented relates these salient details of the distribution function to the electron dynamics in the inner reconnection region.

  18. ANCA-Negative Granulomatosis with Polyangiitis Presenting with Hypertrophic Cranial Pachymeningitis, Abducens Nerve Palsy, and Stenosis of the Internal Carotid Artery

    Directory of Open Access Journals (Sweden)

    Shohei Harabuchi

    2017-01-01

    Full Text Available We report a rare case of granulomatosis with polyangiitis (GPA presenting with hypertrophic cranial pachymeningitis (HCP, abducens nerve palsy, and stenosis of the internal carotid artery (ICA. A 59-year-old Japanese man presented with a year history of nasal obstruction and a 2-month history of slight headache. Histopathological examination of the granulomatous mucosa in the ethmoid sinuses resected by endoscopic sinus surgery revealed necrotizing vasculitis with multinucleated giant cells. The patient was diagnosed with the limited form of GPA as a result of the systemic examination. He declined immunosuppressive treatment. Eighteen months after the diagnosis of GPA, he presented with diplopia and severe headache. Though nasal findings indicating GPA were not observed in the nasal cavity, CT scan revealed a lesion of the right sphenoid sinus eroding the bone of the clivus. Gadolinium-enhanced MRI of the brain showed thickening of the dura mater around the right cavernous sinus and clivus. Magnetic resonance angiography and cerebral angiography revealed narrowing at the C5 portion of the ICA. Intravenous methylprednisolone pulse therapy followed by oral prednisolone and cyclophosphamide resolved headache and dramatically improved HCP and stenosis of the ICA.

  19. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

    Science.gov (United States)

    Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

    2012-05-01

    The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

  20. Functional traits differ between cereal crop progenitors and other wild grasses gathered in the Neolithic fertile crescent.

    Directory of Open Access Journals (Sweden)

    Jennifer Cunniff

    Full Text Available The reasons why some plant species were selected as crops and others were abandoned during the Neolithic emergence of agriculture are poorly understood. We tested the hypothesis that the traits of Fertile Crescent crop progenitors were advantageous in the fertile, disturbed habitats surrounding early settlements and in cultivated fields. We screened functional traits related to competition and disturbance in a group of grass species that were increasingly exploited by early plant gatherers, and that were later domesticated (crop progenitors; and in a set of grass species for which there is archaeological evidence of gathering, but which were never domesticated (wild species. We hypothesised that crop progenitors would have greater seed mass, growth rate, height and yield than wild species, as these traits are indicative of greater competitive ability, and that crop progenitors would be more resilient to defoliation. Our results show that crop progenitors have larger seed mass than wild species, germinate faster and have greater seedling size. Increased seed size is weakly but positively correlated with a higher growth rate, which is primarily driven by greater biomass assimilation per unit leaf area. Crop progenitors also tend to have a taller stature, greater grain yield and higher resilience to defoliation. Collectively, the data are consistent with the hypothesis that adaptations to competition and disturbance gave crop progenitors a selective advantage in the areas surrounding early human settlements and in cultivated environments, leading to their adoption as crops through processes of unconscious selection.

  1. T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN.

    Science.gov (United States)

    Nosko, Anna; Kluger, Malte A; Diefenhardt, Paul; Melderis, Simon; Wegscheid, Claudia; Tiegs, Gisa; Stahl, Rolf A K; Panzer, Ulf; Steinmetz, Oliver M

    2017-01-01

    Th1 cells are central pathogenic mediators of crescentic GN (cGN). Mechanisms responsible for Th1 cell downregulation, however, remain widely unknown. Recently, it was proposed that activation of the Th1-characteristic transcription factor T-bet optimizes Foxp3 + regulatory T (Treg) cells to counteract Th1-type inflammation. Because very little is known about the role of T-bet + Treg1 cells in inflammatory diseases, we studied the function of these cells in the nephrotoxic nephritis (NTN) model of cGN. The percentage of Treg1 cells progressively increased in kidneys of nephritic wild-type mice during the course of NTN, indicating their functional importance. Notably, naïve Foxp3 Cre xT-bet fl/fl mice, lacking Treg1 cells, showed spontaneous skewing toward Th1 immunity. Furthermore, absence of Treg1 cells resulted in aggravated NTN with selectively dysregulated renal and systemic Th1 responses. Detailed analyses of Treg cells from Foxp3 Cre xT-bet fl/fl mice revealed unaltered cytokine production and suppressive capacity. However, in competitive cotransfer experiments, wild-type Treg cells outcompeted T-bet-deficient Treg cells in terms of population expansion and expression levels of Foxp3, indicating that T-bet expression is crucial for general Treg fitness. Additionally, T-bet-deficient Treg cells lacked expression of the Th1-characteristic trafficking receptor CXCR3, which correlated with significant impairment of renal Treg infiltration. In summary, our data indicate a new subtype of Treg cells in cGN. These Treg1 cells are characterized by activation of the transcription factor T-bet, which enhances the overall fitness of these cells and optimizes their capacity to downregulate Th1 responses by inducing chemokine receptor CXCR3 expression. Copyright © 2016 by the American Society of Nephrology.

  2. Concurrent IgG4-related tubulointerstitial nephritis and IgG4 myeloperoxidase-anti-neutrophil cytoplasmic antibody positive crescentic glomerulonephritis: A case report.

    Science.gov (United States)

    Su, Tao; Yang, Li; Cui, Zhao; Wang, Su-Xia; Zhao, Ming-Hui

    2017-05-01

    IgG4-related disease (IgG4-RD) is a newly recognized systemic disease. The typical pathological finding in the kidney is abundant IgG4-positive plasma cell infiltration with characteristic storiform fibrosis in the interstitium. Antibodies of the IgG4 subclass have been linked to certain autoimmune diseases including antiproteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA) of the IgG4 subclass. Here, we report a rare case of kidney injury with concurrent typical IgG4-related tubulointerstitial nephritis and IgG4 subclass of myeloperoxidase (MPO) ANCA-positive necrotizing crescentic glomerulonephritis. A 42-year-old Chinese man presented with repeated epigastric pain, sausage-shaped pancreas observed morphologically in computed tomography, effectiveness of prednisone therapy and was diagnosed with autoimmune pancreatitis. He subsequently developed acute kidney injury. The patient had an elevated serum IgG4, eosinophilia, and positive MPO-ANCA of IgG4-dominant subclass. Renal biopsy revealed necrotizing crescentic nephritis and typical IgG4-related tubulointerstitial nephritis. The patient was treated with a combination of corticosteroids and cyclophosphamide, and a course of rituximab was later added to deplete peripheral B cells. The patient responded well and his renal function improved. This is the first case report of an IgG4-RD with concurrent IgG4-related tubulointerstitial nephritis and IgG4 MPO-ANCA-associated necrotizing crescentic glomerulonephritis. It raises the difficulty in differentiation diagnosis of the two separate diseases that is worthy of further study.

  3. Recria e terminação de borregas mestiças em confinamento alimentadas com níveis crescentes de concentrado na dieta

    Directory of Open Access Journals (Sweden)

    Caroline Bertholini Ribeiro

    2016-12-01

    Full Text Available Objetivou-se avaliar dietas com níveis crescentes de concentrado para borregas confinadas e estabelecer a proporção de concentrado ideal para maximizar a utilização dos nutrientes e o desempenho durante as fases de recria e terminação. Foram confinadas 24 borregas alimentadas com feno de capim-Tifton e níveis crescentes de concentrado na dieta (20, 40, 60 e 80% para avaliação individual do consumo de matéria seca (CMS, digestibilidade dos nutrientes das dietas, ganho médio diário (GMD e eficiência alimentar (EA. As borregas foram abatidas com 47 kg. Na fase de recria, o CMS não foi alterado (P>0,05 pela inclusão de concentrado nas dietas (1176 g/dia. Foi observado efeito quadrático dos níveis de concentrado (P0,05. O CDMS e o valor de NDT apresentaram comportamento quadrático (P0,05. Recomenda-se a inclusão de 71,50% de concentrado na dieta de borregas para maximizar o aproveitamento dos nutrientes e o desempenho na fase de recria e 72,3% de concentrado para fase de terminação.

  4. Arthroscopic repair of large U-shaped rotator cuff tears without margin convergence versus repair of crescent- or L-shaped tears.

    Science.gov (United States)

    Park, Jin-Young; Jung, Seok Won; Jeon, Seung-Hyub; Cho, Hyoung-Weon; Choi, Jin-Ho; Oh, Kyung-Soo

    2014-01-01

    For large-sized tears of the rotator cuff, data according to the tear shape have not yet been reported for repair methodology, configuration, and subsequent integrity. The retear rate after the repair of large mobile tears, such as crescent- or L-shaped tears, is believed to be lower compared with retear rates after the repair of large U-shaped tears that are accompanied by anterior or posterior leaves of the rotator cuff. Cohort study; Level of evidence, 3. Data were collected and analyzed from 95 consecutive patients with a large-sized rotator cuff tear who underwent arthroscopic suture-bridge repair. Patients were divided into 2 groups: those having crescent- or L-shaped tears (mobile tear group, 53 patients) and those having U-shaped tears (U-shaped tear group, 42 patients). The integrity of the repaired constructs was determined by ultrasonography at 4.5, 12, and 24 months. Moreover, clinical evaluations were performed by using the Constant score, the American Shoulder and Elbow Surgeons (ASES) score, and muscle strength at intervals of 3, 6, 12, and 24 months postoperatively. On ultrasonography at 4.5, 12, and 24 months, a retear was detected in 6, 2, and 1 patients in the mobile tear group and in 5, 2, and 1 patients in the U-shaped tear group, respectively. Significant differences in retear rates were not detected between the groups overall or at each time point. Moreover, clinical scores were similar between groups, except for the presence of a temporarily higher Constant score at 12 months in the mobile tear group. With regard to shoulder strength, between-group comparisons indicated no statistically significant difference, either in abduction or external rotation, except for the presence of temporarily higher external rotation strength at 3 months in the mobile tear group. Arthroscopic repair of large-sized rotator cuff tears yielded substantial improvements in shoulder function, regardless of tear retraction, during midterm follow-up. Moreover, the

  5. Adapting to climate change and addressing drought – learning from the Red Cross Red Crescent experiences in the Horn of Africa

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    Joy C.-Y. Muller

    2014-06-01

    Full Text Available The paper presented here is intended to share lessons learnt from the operations that the International Federation of Red Cross and Red Crescent Societies (IFRC and its National Societies undertook from 2008 to 2010 in the Horn of Africa, related to the adaptation to climate change and addressing drought. It acknowledges that to avoid further suffering from drought, not only in Africa (in the Horn and the Sahel region but also other parts of the world, we need to change the way we invest. The IFRC advocates that for a national drought policy to be effective in its implementation, the policy itself will need to be developed with an integrated approach, a strong linkage to climate change adaptation and disaster risk reduction in a country.

  6. An overlap of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis

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    Sujit Surendran

    2017-01-01

    Full Text Available We present a case report of overlap of granulomatosis with polyangiitis (GPA; formerly known as Wegener’s granulomatosis and eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome. We report a 45-year-old female who presented with rapidly progressive renal failure associated with fever, polyarthralgia, and respiratory symptoms with cytoplasmic antineutrophilic cytoplasmic antibody (ANCA and proteinase (PR-3 antigen positivity. Computerized tomography scan of the chest showed diffuse alveolar hemorrhage with renal biopsy revealing pauci-immune necrotizing crescentic glomerulonephritis with intense eosinophilic infiltration suggestive of eosinophilic GPA (EGPA. Our patient had ANCA-associated vasculitis (AAV with features suggestive of both GPA and EGPA. She was treated with methylprednisolone and cyclophosphamide and attained remission after 2 weeks of therapy. This is a rare report of a patient with AAV having features of both EGPA and GPA.

  7. The crescent and the periluminal halo: Two Computed Tomography signs of aortic aneurysm impending rupture?; La semiluna e l`alone periluminale: Due segni con Tomografia Computerizzata di aneurisma aortico a rischio di rottura?

    Energy Technology Data Exchange (ETDEWEB)

    Catalano, Orlando; Cusati, Bianca [Naples, Univ. ``Federico II`` (Italy). Istituto di Scienze Radiologiche; Rotondo, Antonio [Bari, Univ. (Italy). Facolta` di Medicina

    1997-04-01

    Purpose: To assess the prevalence, significance and practical value of two recently described CT signs of instable aneurysm: the crescent sign and the periluminal halo (a low-attenuating internal layer of the thrombus around the patent lumen). Material and methods: Among the CT examination performed in the last 5 years, they retrospectively selected the nonruptured aneurysms with a diameter exceeding 4 cm (no. = 93 average diameter 5.1 cm, unenhanced images in 28 cases and enhanced in 84) and the ruptured aneurysms (no. = 16, average diameter 6.7 cm, unenhanced images in 9 cases and enhanced in 9). They studied the prevalence of the crescent and halo sing, their relationship with the aneurysm diameter, and the effect of contrast enhancement. Results: The crescent sign was identified with a statistically significant prevalence in ruptured ( 37.5 % or cases) over asymptomatic aneurysms (5.5 %); the halo had the same frequency in the 2 groups (12.5 % and 9.5 %). Both signs were more frequent in bigger aneurysms and were recognizable without differences in unenhanced and enhanced images. Conclusions: The crescent sign, though not exclusive of aneurysmal rupture, indicates instability and its detection should lead to careful follow-up or surgical repair. The halo seems to have no real value as risk factor.

  8. Airborne gamma-ray spectrometer and magnetometer survey: Crescent Quadrangle, Burns Quadrangle, Canyon City Quadrangle, Bend Quadrangle, Salem Quadrangle (Oregon). Final report

    International Nuclear Information System (INIS)

    1981-01-01

    An airborne combining radiometric and magnetic survey was performed for the Department of Energy over the area covered by the Burns, Crescent, Canyon City, Bend, and Salem, Washington 1:250,000 National Topographic Map Series, 1 0 x 2 0 quadrangle maps. The survey was a part of DOE's National Aerial Radiometric Reconnaissance program, which is in turn a part of the National Uranium Resource Evaluation program. Data were collected by a helicopter equipped with a gamma-ray spectrometer having a large crystal volume, and a high sensitivity proton precession magnetometer. The radiometric system was calibrated at the Walker Field Calibration pads and the Lake Mead Dynamic Test range. Data quality was ensured throughout the survey by daily test flights and equipment checks. Radiometric data were corrected for live time, aircraft and equipment background, cosmic background, atmospheric radon, Compton scatter, and altitude dependence. The corrected data were statistically evaluated, plotted, and contoured to produce anomaly maps based on the radiometric response of individual geological units. These maps were interpreted and an anomaly interpretation map produced. Volume I contains a description of the systems used in the survey, a discussion of the calibration of the systems, the data processing procedures, the data display format, the interpretation rationale, and the interpretation methodology. A separate Volume II for each quadrangle contains the data displays and the interpretation results

  9. Sinergia entre aditivo vegetal e níveis crescentes de promotores de crescimento sobre o desempenho produtivo e morfometria intestinal de frangos de corte

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    Fabiano Gomes Gonçalves

    2014-02-01

    Full Text Available Objetivou-se avaliar o efeito da adição de níveis crescentes de antibióticos associados ao farelo integral de pimenta rosa (FIPR sobre o desempenho produtivo e morfometria intestinal de frangos corte. Utilizaram-se 528 pintos Cobb, machos, distribuídos em um delineamento inteiramente casualizado, com seis tratamentos e quatro repetições de 22 animais cada, constituído pelos grupos T1 - Controle Negativo (CN - Dieta basal sem FIPR e sem antibióticos; T2 - Controle Positivo (CP - Dieta Basal com 1,2% FIPR; T3 - CP + 11ppm bacitracina zinco e 17ppm salinomicina; T4 - CP + 22ppm bacitracina zinco e 34ppm salinomicina; T5 - CP + 33ppm bacitracina zinco e 51ppm salinomicina; T6 - CP + 45ppm bacitracina zinco e 67ppm salinomicina. No período de 1-43 dias de idade, observou-se que a adição de FIPR com ou sem antibiótico reduziu (P≤0,05 o consumo e melhorou a conversão alimentar, comparado com CN. Verificou-se que os frangos alimentados com FIPR associado aos antibióticos, em valores acima de 22mg kg-1 de bacitracina de zinco e 34mg kg-1 de salinomicina, tiveram maiores alturas de vilosidades intestinais que o CN (P≤0,05. O FIPR pode ser utilizado em substituição aos antibióticos sem queda de desempenho animal e com a manutenção da viabilidade e do fator de produção.

  10. Seasonal deformation and active landslide thickness revealed by spaceborne InSAR observations: a case study of Crescent lake landslide, WA

    Science.gov (United States)

    Hu, X.; Lu, Z.; Pierson, T. C.; Kramer, R.

    2017-12-01

    Understanding the precipitation triggering mechanism and quantifying the creeping landslide thickness are important to conduct early warnings and estimate potential failure volume and runout extent. However, it is problematic to use traditional geodetic methods to identify the active landslide boundaries and capture the transient mobility over hilly and vegetated landslide landscape. Here we present a novel InSAR processing strategy to characterize the spatial distribution and temporal behavior of the landslide movement in response to precipitation over Crescent lake landslide, WA using spaceborne SAR data of ALOS-1 PALSAR-1, ALOS-2 PALSAR-2 and Sentinel-1A. Time-series measurements reveal the seasonal deformation of landslide lobe, showing a much larger magnitude compared to the motion at lower elevated terrain expressed by an off-slide GPS station, suggesting an amplified hydrological loading effect associated with thick unconsolidated zone. Thanks to the high temporal resolution of Sentinel-1A and on-slide GPS data, we capture the progressive incipient motions in the wet season, characterized by the elastic slope-normal contraction due to loading during antecedent rainfall, followed by downslope slip and lateral propagation in less than one-month intense precipitation, because the elevated pore pressure and the reduced friction at the basal instigate the shear motion. The proposed threshold precipitation concept, in terms of the intensity and duration, can be an integral part of the landslide warning system. The active thickness can be inverted using three-dimensional (3D) displacement map based on the principle of mass conservation. We extract quasi-3D displacements using two independent (ascending and descending) InSAR measurements assuming that the targets move exclusively along the aspect direction on the slope-parallel plane. This routine of the extraction of quasi-3D displacement and the inversion of active lobe thickness can be utilized in the study of

  11. OBTENCIÓN DE BIOETANOL PRIMARIO A PARTIR DE LA BIOMASA LIGNOCELULÓSICA DEL MATE (Crescentía cujete

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    Ely Fernando Sacón Vera

    2013-12-01

    Full Text Available El objetivo de esta investigación fue obtener bioetanol a partir de la biomasa lignocelulósica del mate (Crescentía cujete. Se empleó un Diseño Completamente al Azar en arreglo bifactorial AxB con tres réplicas por cada tratamiento. Se manipularon los factores de estudio: A. Concentración de ácido sulfúrico (2.5%, 5% y 7.5% y B. Cantidad de levadura Saccharomyces cerevisiae (2 y 5 mL. Se evaluaron las variables: acidez, °Brix, Grado Gay Lussac, Azucares totales y reductores. Los resultados encontrados demostraron que la hidrólisis ácida permitió desdoblar la lignocelulosa ya que incrementaron los azúcares reductores fue de 13.82% en comparación con los encontrados en la pulpa 6.46%; de la misma forma se obtuvo mayor contenido de alcohol (20.70 GL en el tratamiento a2b2 (5% de ácido sulfúrico + 5 mL de levadura S. cerevisiae, el cual presentó menor contenido de acidez con 0.643%, los °Brix fue de 18.47, mientras que el tratamiento a2b2 presentó mayor contenido de acidez con 0.893%, el a2b1 obtuvo menor contenido de °Brix con 15.00, y el a1b1 presentó menor contenido de Grado Gay Lussac con 8.33. De esta forma se concluye que es posible obtener un alcohol primario a partir de la biomasa del mate sometido a una hidrólisis ácida al 5% y fermentación con S. cerevisiae al 2% en relación al peso de la pulpa del mate.

  12. Efeito de níveis crescentes de levedura de álcool em rações contendo fígado bovino sobre a performance de larvas de jundiá (Rhamdia quelen Effect of crescent levels of yeast of alcohol used in rations containing bovine liver on larvae of (Rhamdia quelen performance

    Directory of Open Access Journals (Sweden)

    Rosamari Piaia

    1997-06-01

    Full Text Available O presente trabalho foi realizado com a finalidade de avaliar o efeito de diferentes níveis de levedura sobre o desempenho inicial de larvas de Rhamdia quelen durante as trêss primeiras semanas de vida. Um total de 3000 larvas foram distribuídas em quinze grupos, em um sistema de criação com reutilização de água, termoregulada. Utilizou-se cinco tratamentos com níveis crescentes de levedura (T1 - 50%, T2 - 60%, T3 - 70%, T4 - 80% e T5 - 90% em substituição ao fígado bovino fresco. Os níveis de proteína bruta (PB e energia digestível variaram de 41,36 a 26,56% de PB e 3197 a 2789kcal ED/kg. A granulometria dos alimentos testados foi de 100 a 200mi, 200 a 400mi e 400 a 600mi para as três semanas experimentais, respectivamente. O alimento foi fornecido a vontade entre 8 e 20 horas. Dentro dos limites de proteína estudados houve efeito positivo de níveis mais elevados de PB sobre os comprimentos total e padrão e peso individual. Porém houve um efeito negativo sobre a sobrevivência das larvas de jundiá Rhamdia quelen.The present study was developed with the purpose of evaluating the effects of different protein levels in initial performance of Rhamdia quelen larvae during the first three weeks of life. The sample contained 3000 larvae distributed in fifteen groups, maintained in controlled conditions of culture and utilizing termoregulatory water re-use system. Five crescent levels of yeast (T1 50%, T2 60%, T3 70%, T4 80% and T5 90% were used in rations in substituition of bovine liver. Levels of crude protein and digestible energy varied 41,36% to 26,56% CP and from 3197 to 2789 kcal ED/kg. The granulometry of tested food was of 100 a 200mu, 200 a 400mu and 400 a 600mu for three experimental weeks respectively. Food distribution provided at ease between 8 Am and 8 Pm. Within the net protein used in this research, there was found a positive effect for the highest protein levels for total, standard lenght and individual weight

  13. Manganese-bearing deposits near Lake Crescent and Humptulips, Washington: Chapter A in Contributions to economic geology (short papers and preliminary reports), 1927: Part I - Metals and nonmetals except fuels

    Science.gov (United States)

    Pardee, J.T.

    1927-01-01

    The Crescent mine, situated a short distance west of Lake Crescent, in the Olympic Mountains of Washington, yields an unusually high grade of manganese ore, which is suitable for making steel. Several manganiferous lodes of promising appearance have been found in the same area, and some near Humptulips, on the south side of the mountains. These and deposits on Skokomish River and at other places in the Olympic region are distributed around three sides of the mountains through a distance of 110 miles.The characteristic and generally the most abundant manganese mineral in this belt is bementite, a silicate of manganese that is rare elsewhere. Hausmannite, a suboxide of manganese (Mn3O4) that is also rather uncommon, occurs in several of the deposits and is locally abundant in the Crescent mine, where it forms the most valuable constituent of the ore. In addition more or less of a manganiferous carbonate is present, and bodies composed of fine-grained quartz and iron oxides form a large but separate part of the lodes.The deposits are associated with an impure red limestone of marine origin, which is probably to be correlated with the Franciscan formation of California. The limestone is overlain by a thick series of basaltic flows and tuff of Tertiary age that are partly altered to greenstone. The manganese is thought to have been deposited originally with the limestone as a carbonate. The concentration and change of much of it from the carbonate into bementite and hausmannite are believed to have been caused by warm solutions charged with silica that were expressed from the lavas or their magma. Afterward mountain-building movements and erosion elevated and exposed the manganiferous beds.The beds at the horizon of the manganiferous deposits are very incompletely explored and are to be regarded as the possible source of large quantities of ore.

  14. ANCA positivity in a patient with infective endocarditis-associated glomerulonephritis: a diagnostic dilemma.

    Science.gov (United States)

    Ghosh, Gopal Chandra; Sharma, Brijesh; Katageri, Bhimarey; Bhardwaj, Minakshi

    2014-09-01

    Glomerulonephritis (GN) is an immunological phenomenon in bacterial endocarditis. These may be pauci-immune/vasculitic GN, post-infective GN, and sub-endothelial membranoproliferative glomerulonephritis. Each type of glomerulonephritis usually occurs in isolation. We report a case of infective endocarditis with dual existence of pauci-immune/vasculitic GN and post infective type of GN at the same time.

  15. Mycorrhizal dependency of mangaba tree under increasing phosphorus levels Dependência micorrízica de mangabeira em doses crescentes de fósforo

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    Júlio Alves Cardoso Filho

    2008-07-01

    Full Text Available The objective of this study was to evaluate the mycorrhizal dependency of mangaba tree (Hancornia speciosa plantlets, under increasing levels of phosphorus fertilization. The experimental design was completely randomized in a 4×5 factorial arrangement with three mycorrhizal fungi inocula - Gigaspora margarita, Glomus etunicatum, or a pool of native mycorrhizal fungi (Acaulospora longula, Glomus clarum, Gigaspora albida, Paraglomus sp. -, and a nonmycorrhizal control, in combination with five levels of phosphorus applied to the substrate: 0, 25, 50, 75, and 100 mg kg-1. After 180 days of growth, plantlets with inoculation of native mycorrhizal pool produced more shoot and root dry biomass and had higher shoot phosphorus content and accumulation. The noninoculated control showed the lowest values, independently of the phosphorus level. The highest relative mycorrhizal dependency occurred with the inoculation of native mycorrhizal fungi. Plants with mycorrhizal fungi did not respond to phosphorus addition above 50 mg kg-1. Mangaba tree is highly dependent on mycorrhiza, but the degree of dependency varies according to phosphorus levels and fungal inocula. In general, mangaba tree is more responsive to mycorrhizal fungi inoculation than to phosphorus addition.O objetivo deste trabalho foi avaliar a dependência micorrízica de mudas de mangaba (Hancornia speciosa, em doses crescentes de fósforo. O delineamento experimental foi inteiramente casualizado, em arranjo fatorial 4´5 com três inóculos de fungos micorrízicos - Gigaspora margarita, Glomus etunicatum, ou uma mistura de espécies de fungos micorrízicos nativos (Acaulospora longula, Glomus clarum, Gigaspora albida e Paraglomus sp. -, e um controle não micorrízico, combinados a cinco doses de fósforo no substrato: 0, 25, 50, 75 e 100 mg kg-1. Após 180 dias, as mudas com inoculação dos fungos micorrízicos nativos produziram mais biomassa seca de parte aérea e raízes e apresentaram

  16. Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis

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    Nicholas D. Ward

    2014-01-01

    Full Text Available A rat model of antineutrophil cytoplasmic antibody (ANCA associated vasculitides reveals crescentic glomerulonephritis as seen in human renal biopsies and diffuse lung hemorrhage that is not well documented in human lung biopsies. A 64-year-old male, with shortness of breath and mild elevation of serum creatinine, was found to have a positive serum test for ANCA, but negative antiglomerular basement membrane antibody. A renal biopsy showed pauci-immune type of crescentic glomerulonephritis and focal arteritis. The prior lung wedge biopsy was retrospectively reviewed to show diffuse hemorrhage and hemosiderosis with focal giant cells. In addition, small arteries revealed subtle neutrophil aggregation, and margination along vascular endothelium, but no definitive vasculitis. The pathology of ANCA associated vasculitides results from activated neutrophils by ANCA and subsequent activation of the alternative complement cascade with endothelial injury, neutrophil aggregation and margination. Our findings, after the correlation between lung biopsy and renal biopsy, imply that the top differential diagnosis in the lung biopsy should be microscopic polyangiitis when diffuse pulmonary hemorrhage and hemosiderosis are present in this ANCA-positive patient.

  17. A Case Report Describing a Rare Presentation of Simultaneous Occurrence of MPO-ANCA-Associated Vasculitis and Rheumatoid Arthritis.

    Science.gov (United States)

    Foray, Nathalie; Hudali, Tamer; Papireddy, Muralidhar; Gao, John

    2016-01-01

    Background . Renal-limited myeloperoxidase vasculitis with simultaneous rheumatoid arthritis is reported as a rare occurrence. Review of literature suggests that most patients had a diagnosis of rheumatoid arthritis for several years prior to presenting with renal failure from myeloperoxidase vasculitis. Case Presentation . A 58-year-old Caucasian male presented to the hospital experiencing malaise, fevers, decreased oral intake, nausea, and vomiting for one week duration. His past medical history consisted of newly diagnosed but untreated rheumatoid arthritis, hypertension, and non-insulin-dependent diabetes mellitus. He was found to have acute renal failure, proteinuria, and hypoglycemia. Standard therapy, including intravenous fluids, did not improve his acute renal failure. A vasculitis workup resulted in a positive myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). Renal biopsy revealed crescentic glomerulonephritis (GN) pauci-immune type, suggestive of MPO-ANCA-associated vasculitis (MPO-AAV). Treatment consisted of prednisone, cyclophosphamide, and seven cycles of plasmapheresis, in addition to hemodialysis for uremia. Upon discharge, he received hemodialysis for another week and continued treatment with cyclophosphamide and prednisone. Conclusion . Patients with longstanding rheumatoid arthritis may develop renal failure due to nonsteroidal anti-inflammatory medication use and AA type amyloidosis; however, necrotizing glomerulonephritis with crescent formation has been rarely reported. This stresses the importance of early recognition and swift initiation of treatment.

  18. A Case Report Describing a Rare Presentation of Simultaneous Occurrence of MPO-ANCA-Associated Vasculitis and Rheumatoid Arthritis

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    Nathalie Foray

    2016-01-01

    Full Text Available Background. Renal-limited myeloperoxidase vasculitis with simultaneous rheumatoid arthritis is reported as a rare occurrence. Review of literature suggests that most patients had a diagnosis of rheumatoid arthritis for several years prior to presenting with renal failure from myeloperoxidase vasculitis. Case Presentation. A 58-year-old Caucasian male presented to the hospital experiencing malaise, fevers, decreased oral intake, nausea, and vomiting for one week duration. His past medical history consisted of newly diagnosed but untreated rheumatoid arthritis, hypertension, and non-insulin-dependent diabetes mellitus. He was found to have acute renal failure, proteinuria, and hypoglycemia. Standard therapy, including intravenous fluids, did not improve his acute renal failure. A vasculitis workup resulted in a positive myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA. Renal biopsy revealed crescentic glomerulonephritis (GN pauci-immune type, suggestive of MPO-ANCA-associated vasculitis (MPO-AAV. Treatment consisted of prednisone, cyclophosphamide, and seven cycles of plasmapheresis, in addition to hemodialysis for uremia. Upon discharge, he received hemodialysis for another week and continued treatment with cyclophosphamide and prednisone. Conclusion. Patients with longstanding rheumatoid arthritis may develop renal failure due to nonsteroidal anti-inflammatory medication use and AA type amyloidosis; however, necrotizing glomerulonephritis with crescent formation has been rarely reported. This stresses the importance of early recognition and swift initiation of treatment.

  19. Biodisponibilidade do P e digestibilidade aparente do N em dietas de suínos suplementadas com níveis crescentes de fitase, balanceadas de acordo com o conceito de proteína ideal

    Directory of Open Access Journals (Sweden)

    J.A. Moreira

    2011-12-01

    Full Text Available Avaliaram-se o efeito de inclusão crescente de fitase (unidade de fitase - UF em dietas para suínos na fase de crescimento pela técnica de diluição isotópica. Foram utilizados 20 suínos, machos castrados, em delineamento de blocos ao acaso, com cinco tratamentos - 0, 250, 500, 750 e 1000UF/kg da ração - e quatro repetições. Os animais foram alojados em gaiolas metabólicas por 17 dias, sendo 10 dias para adaptação e sete dias para coleta de fezes e urina. Amostras de sangue foram coletadas por cinco dias. No primeiro dia da fase experimental, cada animal recebeu por via endovenosa em solução radioativa com 7,4MBq de 32P. A Quantum Phytase foi eficiente em disponibilizar o P fítico para suínos em crescimento até 750UF/kg de dieta, sendo que 500UF/kg da ração foi o indicado para dietas à base de milho e farelo de soja, formuladas de acordo com o conceito de proteína ideal.

  20. Flipped Science Inquiry@Crescent Girls' School

    Directory of Open Access Journals (Sweden)

    Peishi Goh

    2017-06-01

    Full Text Available This study shares the findings of a school-based Action Research project to explore how inquiry-based science practical lessons designed using the Flipped Science Inquiry@CGS classroom pedagogical model influence the way students learn scientific knowledge and also students' development of 21st century competencies, in particular, in the area of Knowledge Construction. Taking on a broader definition of the flipped classroom pedagogical model, the Flipped Science Inquiry@CGS framework adopts a structure that inverted the traditional science learning experience. Scientific knowledge is constructed through discussions with their peers, making use of their prior knowledge and their experiences while engaging in hands-on activities. Through the study, it is found that with the use of the Flipped Science Inquiry@CGS framework, learning experiences that are better aligned to the epistemology of science while developing 21st century competencies in students are created.

  1. Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    DEFF Research Database (Denmark)

    Morishita, Kimberly A; Moorthy, Lakshmi N; Lubieniecka, Joanna M

    2017-01-01

    diagnosed before their eighteenth birthday as having granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), or ANCA-positive pauci-immune glomerulonephritis. The primary outcome measure was achievement of disease remission...

  2. Rapidly progressive glomerulonephritis in adolescents – aetiology and treatment based on case reports

    Directory of Open Access Journals (Sweden)

    Beata Banaszak

    2017-06-01

    Full Text Available Rapidly progressive glomerulonephritis is a disease characterised by an abrupt drop in glomerular filtration rate in a short period of time, which is caused by crescent formation seen in at least 50% of glomeruli. Two cases presented below illustrate rapid progressive glomerulonephritis in adolescents as a disease of heterogeneous aetiology that can develop both in the course of primary glomerulopathies and glomerulopathies secondary to systemic vasculitis. In the first case of an 11-year-old girl, nephritic syndrome with renal failure was accompanied by the presence of anti-myeloperoxidase antibodies in the serum, which in combination with the histopathological picture of the kidneys indicating pauci-immune rapidly progressive glomerulonephritis was the basis for the diagnosis of renal limited vasculitis. In the second case of a 16-year-old boy, an adverse course of acute post-streptococcal glomerulonephritis with features of severe and persistent glomerular filtration impairment was an indication for the verification of the diagnosis and identification of rapidly progressive glomerulonephritis based on a biopsy examination. Prompt diagnosis and inclusion of combined immunosuppressive therapy provided the chance to preserve renal function.

  3. A case of exorbitism in association with Wegener′s granulomatosis with renal involvement

    Directory of Open Access Journals (Sweden)

    S Beji

    2012-01-01

    Full Text Available Wegener′s granulomatosis (WG is a necrotizing granulomatous vasculitis invol-ving the nose, paranasal sinuses, lungs, and kidneys. Ocular involvement can occur in about 50% of cases. There are very few reports of WG with orbital inflammation and exorbitism. We report a case of a female patient who presented with exorbitism related to orbital inflammation secondary to WG, with renal involvement. A 29-year-old woman with a previous history of recurrent pan-sinusitis presented with bilateral exophthalmos and renal failure with rapidly progressive glo-merulonephritis. Computed tomography showed extensive bilateral soft tissue in the retro-orbital area. Immunologic tests showed the presence of type-C anti-neutrophil cytoplasmic antibodies and renal biopsy revealed pauci immune crescentic glomerulonephritis. The patient was treated with corticosteroids and pulses of cyclophosphamide followed by azathioprine and trimethoprim-sulfamethoxazole. After a follow-up of 10 months, the renal outcome was favorable with improvement of renal function but there was persistence of exorbitism and loss of visual function. Our case suggests that WG should be considered in the differential diagnosis of persistent bila-teral exophthalmos. Prompt recognition of this early manifestation is important for the institution of early treatment.

  4. Kaposi′s sarcoma with HHV8 infection and ANCA-associated vasculitis in a hemodialysis patient

    Directory of Open Access Journals (Sweden)

    Lilia Ben Fatma

    2013-01-01

    Full Text Available The association between Kaposi′s sarcoma (KS and human herpes virus eight (HHV-8 infection is rarely reported in hemodialysis (HD patients. We report here the rare association of KS, HHV-8 and hepatitis C virus (HCV infection as well as syphilis in a HD patient. We report the case of a 72-year-old woman who presented with microscopic polyangiitis with alveolar hemorrhage and pauci-immune necrosing and crescentic glomerulonephritis as well as renal failure requiring HD. Biological tests showed positive HCV and syphilis tests. The patient was treated by HD and intravenous pulse, followed by oral corticosteroids and six cyclophosphamide monthly pulses with remission of the alveolar hemorrhage, but without renal functional recovery as the patient remained HD dependent. Five months after the first treatment administration, she developed extensive purpuric lesions on her lower limbs, abdomen face and neck. A skin biopsy showed KS. The HHV-8 test was positive, with positive polymerase chain reaction-HHV8 in the serum and skin. After immunosuppression withdrawal, the KS skin lesions regressed rapidly without relapse after 12 months of follow-up, but alveolar hemorrhage relapsed after 16 months of follow-up. Our case showed that the immunosuppressed state related to multiple factors such as aging, vasculitis, HHV-8, HCV, syphilis, immunosuppressive therapy and HD may all have contributed to the development of KS in our patient.

  5. TEXTURA DE FEIJÃO-VAGEM (Phaseolus vulgaris L PROCESSADO OU NÃO: EFEITO DA APLICAÇÃO DE CONCENTRAÇÕES CRESCENTES DE CÁLCIO VIA ABSORÇÃO RADICULAR

    Directory of Open Access Journals (Sweden)

    Simone Palma FÁVARO

    1998-05-01

    Full Text Available Esta investigação teve como objetivo estudar o efeito do cultivo de feijão-vagem com doses crescentes de cálcio na textura das vagens antes e após processo de enlatamento. O experimento foi desenvolvido com a cultivar UEL 1, utilizando-se areia grossa como substrato. Os tratamentos constaram das seguintes concentrações de cálcio em solução nutritiva: 0, 75, 150 e 300 ppm. Foram determinados os teores de cálcio das vagens in natura, substâncias pécticas e textura das vagens in natura e processada. As concentrações de cálcio nas vagens aumentaram em paralelo à elevação dos níveis de cálcio adicionados à solução nutritiva. Os teores de pectina solúvel nas vagens in natura não diferiram entre os tratamentos. Houve um acréscimo da quantidade de pectina insolúvel em função do aumento das doses de cálcio. Após o processamento térmico ocorreu uma solubilização das pectinas. A maior concentração de pectina solúvel nas vagens enlatadas foi observada nas vagens cultivadas sem adição de cálcio na solução nutritiva. As medidas de textura demonstraram uma tendência de aumento de firmeza das vagens concomitante à elevação nos teores de cálcio antes e após o processo de enlatamento.This study aimed to investigate the effect of increasing calcium concentrations applied in nutrient solution in snap beans. Snap beans of cultivar UEL 1 were grown in coarse sand with nutrient solution supplying calcium at the following levels: 0, 75, 150 and 300 ppm. Fresh pods were analysed for calcium content. Fresh and processed pods were analysed for pectin content and texture. The calcium concentration in bean pods was increased when the calcium level in the nutrient solution was raised. There was no difference among the treatments for content of soluble pectins, however the content of insoluble pectins raised when calcium was added to the nutrient solution. An increasing in the content of soluble pectin was observed after the

  6. Rice seedling and plant development as affected by increasing rates of penoxsulam under controlled environments Desenvolvimento de plântulas e plantas adultas de arroz em função de doses crescentes de penoxsulam em ambiente controlado

    Directory of Open Access Journals (Sweden)

    G. Concenço

    2006-01-01

    Full Text Available Rice is a major staple in many countries. Weed control is one of the factors limiting higher rice yield. ALS (acetolactate synthase-inhibiting herbicides are desirable weed control herbicides because of their high efficacy, low toxicity to mammalians, and low rates used. An important herbicide characteristic is high selectivity to the crop, since it facilitates fast crop establishment and greater crop advantage over the weeds. The objectives of this work were to study the effects of increasing rates of the ALS-inhibiting herbicide penoxsulam on seed integrity and germination, and seedling and plant development of rice cv. BRS Pelota under controlled laboratory and greenhouse conditions. The results showed that penoxsulam affected rice germination and seedling and plant growth at rates above 54 g a.i. ha-1, and that penoxsulam is safe for rice seedling development at the currently recommended rates.O arroz é componente importante da dieta humana em vários países. Entre os fatores que limitam o aumento na sua produtividade está o controle de plantas daninhas. Os herbicidas inibidores da ALS (acetolactato sintase são preferidos em razão da alta eficiência no controle de plantas daninhas, da baixa toxicidade aos mamíferos e das baixas doses utilizadas. Uma característica importante que um herbicida deve possuir é a alta seletividade à cultura, pois ela implica estabelecimento mais rápido, com vantagem competitiva sobre as plantas daninhas. O objetivo deste trabalho foi estudar os efeitos do herbicida inibidor da ALS penoxsulam em doses crescentes sobre a integridade e germinação das sementes, bem como sobre o desenvolvimento inicial das plântulas e da planta adulta do cultivar BRS Pelota, sob condições de ambiente controlado (laboratório e casa de vegetação. Os resultados mostraram que o penoxsulam afetou a germinação e o crescimento de plântulas e plantas adultas nas doses acima de 54 g i.a. ha-1 e que ele é seguro para o

  7. Unmasking of complements using proteinase-K in formalin fixed paraffin embedded renal biopsies

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    R Nada

    2016-01-01

    Full Text Available Renal biopsy interpretation requires histopathology, direct immunofluorescence (DIF and electron microscopy. Formalin-fixed, paraffin-embedded tissue (FFPE sent for light microscopy can be used for DIF after antigen retrieval. However, complement staining has not been satisfactory. We standardized DIF using proteinase-K for antigen retrieval in FFPE renal biopsies. A pilot study was conducted on known cases of membranous glomerulonephritis (MGN, membranoproliferative type-1 (MPGN-1, immunoglobulin A nephropathy (IgAN, and anti-glomerular basement disease (anti-GBM. Immunofluorescence panel included fluorescein isothiocyanate (FITC conjugated IgG, IgA, IgM, complements (C3 and C1q, light chains (kappa, lambda and fibrinogen antibodies. After standardization of the technique, 75 renal biopsies and 43 autopsies cases were stained. Out of 43 autopsy cases, immune-complex mediated glomerulonephritis (GN was confirmed in 18 cases (Lupus nephritis-11, IgAN-6, MGN-1, complement-mediated dense deposit disease (DDD-1 and monoclonal diseases in 4 cases (amyloidosis-3, cast nephropathy-1. Immune-mediated injury was excluded in 17 cases (focal segmental glomerulosclerosis -3, crescentic GN-6 [pauci-immune-3, anti-GBM-3], thrombotic microangiopathy-5, atherosclerosis-3. Renal biopsies (n-75 where inadequate or no frozen sample was available; this technique classified 52 mesangiocapillary pattern as MPGN type-1-46, DDD-2 and (C3GN-4. Others were diagnosed as IgAN-3, lupus nephritis-2, MGN-4, diffuse proliferative glomerulonephritis (DPGN-1, Non-IC crescentic GN-1, monoclonal diseases-3. In nine cases, DIF on FFPE tissue could not help in making diagnosis. Proteinase-K enzymatic digestion of FFPE renal biopsies can unmask complements (both C3 and C1q in immune-complexes mediated and complement-mediated diseases. This method showed good results on autopsy tissues archived for as long as 15 years.

  8. Valor Nutritivo de Silagens de Híbridos de Sorgo (Sorghum bicolor (L. Moench sob Doses Crescentes de Adubação Nutritive Value of Five Sorghum Hybrids (Sorghum bicolor (L. Moench Silages under Increasing Fertilization Levels

    Directory of Open Access Journals (Sweden)

    Magno José Duarte Cândido

    2002-02-01

    Full Text Available Avaliou-se o valor nutritivo das silagens de cinco híbridos de sorgo (AG2002, AG2005E, AGX202, AGX213 e AGX215, cultivados sob doses crescentes de adubação (tratamento sem adubação, 0,5; 1,0; e 2,0 vezes a recomendação de adubação, consistindo de 0; 45,5; 91; e 182 kg/ha de N; 0; 49; 98; e 196 kg/ha de P2O5 ; e 0; 14; 28; e 56 kg/ha de K2O, além de 0; 42; 84; e 168 kg/ha de S, respectivamente, advindos da utilização de sulfato de amônio em cobertura, adotando-se o esquema fatorial 5x4 no delineamento em blocos casualizados, com quatro repetições. O plantio foi realizado no dia 06.11.1997, e as parcelas foram colhidas com os grãos no estádio farináceo. De cada parcela útil retirou-se uma amostra para enchimento dos silos experimentais, que, após 60 dias, foram abertos e amostrados novamente para se proceder à pré-secagem e às determinações do valor nutritivo (PB, fração fibrosa e DIVMS. Os dados foram interpretados por análise de variância e regressão, desdobrando-se a interação híbrido x adubo independentemente da sua significância. Os fatores qualitativos foram comparados, utilizando-se o teste de Tukey. Os modelos foram escolhidos, baseando-se na significância dos coeficientes de regressão, utilizando o teste de "t", Student, a 10% de probabilidade, e no coeficiente de determinação. O valor nutritivo das silagens diferiu entre os híbridos, observando-se maior valor nutritivo para a silagem do AG2005E, enquanto as silagens do AG2002 e do AGX213 apresentaram maior produção de nutrientes por unidade de área. O valor nutritivo das silagens foi afetado pelas doses de recomendação de adubação, embora de forma inconsistenteThe nutritive value of five sorghum hybrids (AG-2002, AG-2005E, AG-X202, AG-X213 and AG-X215 silages, cultivated under increasing fertilization levels (control, 0.5, 1.0, and 2.0 times of the recommended fertilization, corresponding to 0, 45.5, 91, and 182 kg/ha N; 0, 49, 98, and 196 kg

  9. Possible consequences of increasing life expectancy in Brazil: the perspective of a European historical demographer Possíveis conseqüências da crescente longevidade no Brasil: perspectiva de um demógrafo

    Directory of Open Access Journals (Sweden)

    Arthur E. Imhof

    1987-10-01

    . Mais da metade das mulheres (52,8% da Alemanha sobreviveram até 80 anos de idade, de 1982/84, e quase metade dos homens (47,3% sobreviveram até 75 anos. A durabilidade da vida é hoje garantida de tal forma que teria sido inconcebível há poucas gerações. O tripé clássico de "peste, fome e guerra" ameaçava os nossos antepassados em todos os lugares e todo tempo. A transição radical de uma vida anteriormente incerta para a vida segura atual, resultado da repressão daquele tripé, levou a conseqüências imprevistas para o convívio em comunidade. Nossos antepassados eram obrigados a viver em sociedade, bem integrados na busca de sua sobrevivência física, e subordinar seus dejetos pessoais aos valores comuns; mas, agora, ao menos na sua maior parte, estas pressões desapareceram. O ego, com muito mais segurança, passou a ocupar lugar de destaque. Um número crescente de pessoas tem optado por uma vida solitária: o número de casamentos diminui a cada ano, o número de divórcios aumenta; em Berlim Ocidental, mais da metade (52,3% das "famílias" já se compõe de uma só pessoa. Durante os últimos 6 anos o número anual de nascimentos foi insuficiente para assegurar a reposição da população. O problema da Alemanha não é de explosão demográfica e, sim, de implosão. Os seres humanos já não parecem ser "animais sociais", como se supunha. Na verdade, a "peste, fome e guerra" os obrigavam a este comportamento. Quando estas condições ameaçadoras se modificaram e a vida se tornou mais segura, mesmo sem estarem integrados numa sociedade, os seres humanos vêm se tornando cada vez mais solitários. Não é a existência de população acima de 60 ou 65 anos que se constituiu um fator decisivo neste contexto, mas, sim, a percepção dos adultos de sua condição humana, desde que são eles que organizam suas vidas, que constroem comunidades e que com freqüência cada vez maior contraem uniões pessoais como um fim em si mesmo, sem laços chegados ou

  10. Acúmulo de N, K, Ca, Mg e S na matéria seca da parte aérea de mudas de cajueiro-anão-precoce submetidas a níveis crescentes de matéria orgânica

    Directory of Open Access Journals (Sweden)

    Lima Rosiane de Lourdes Silva de

    2003-01-01

    Full Text Available Com o objetivo de verificar os efeitos de níveis crescentes de matéria orgânica no acúmulo de macronutrientes de porta-enxertos de cajueiro-anão-precoce em 4 estádios de crescimento, foi conduzido experimento na área experimental do Departamento de Irrigação e Drenagem da Universidade Federal do Ceará, em Fortaleza, Ceará, no período de abril a junho de 1995. Utilizou-se como substrato mistura de solo e húmus de minhoca em proporções variadas. Para o plantio, utilizou-se semente de cajueiro-anão-precoce progênie CCP-76. Os tratamentos resultaram da aplicação de cinco níveis de matéria orgânica (0; 100; 200; 300 e 400 cm³/2,5kg solo e 4 épocas de avaliação (15; 30; 45 e 60 dias após a germinação. O delineamento experimental foi o inteiramente casualizado, em esquema de parcela subdividida, com quatro repetições e seis plantas por parcela. Amostras do material vegetal foram submetidas à digestão nítricoperclórica, para determinação de K, Ca, Mg e S, respectivamente, e sulfúrica, para determinar o N. A adição de níveis crescentes de matéria orgânica ao substrato apresentou efeito linear positivo, para o N e K, atingindo o máximo para a dose de 400 cm3. Em relação aos efeitos das épocas, verificou-se efeito linear negativo. Quanto ao Ca, Mg e S, por serem considerados de baixa mobilidade no floema, estes apresentaram tendências de concentração com o incremento de massa seca das mudas.

  11. Renal histology in the elderly: indications and outcomes.

    LENUS (Irish Health Repository)

    Brown, Catherine M

    2011-06-28

    Background: Renal disease is being increasingly diagnosed in the elderly. However, reports on biopsy-confirmed renal disease in this population are limited. The aim of this study was to give an overview of the most important indications, diagnoses and outcomes of renal biopsies in the elderly in our center. Methods: This was a retrospective review of all elderly renal biopsies over 5 years. Patients were eligible for inclusion if they were aged =65 years and had had a native kidney biopsy performed. The data recorded included age, sex, indications for biopsy, histological diagnoses and outcomes. Results: During this time, 1,372 native renal biopsies were performed. Of these, 236 (17%) were in patients aged =65 years; 150 male (64%) and 86 female (36%). The most common indications for biopsy were acute renal failure and nephrotic syndrome. Common diagnoses included pauci-immune crescentic glomerulonephritis, tubulointerstitial nephritis, membranous nephropathy, IgA nephropathy and chronic thrombotic microangiopathy. Long-term follow-up of 3 years was available for 102 patients; median serum creatinine at the time of biopsy was 427 µmol\\/L (interquartile range 204-702) and at 3 years post biopsy had fallen to 192 µmol\\/L (interquartile range 152-408). Conclusions: In our center, 17% of native kidney biopsies are performed in elderly patients aged =65 years. In our experience, this procedure was safe and had a 97% diagnostic rate. The available follow-up data of patients suggest that renal histology is not only of benefit in diagnosis but also of potential value in terms of prognosis and treatment.

  12. Aortic stenosis concomitant with microscopic polyangiitis: a challenge in medical reasoning and thinking.

    Science.gov (United States)

    Gutierrez, Paulo Sampaio; Aiello, Vera Demarchi

    2014-01-01

    Microscopic polyangiitis (MPA) is part of the anti-neutrophil cytoplasmic antibodies (ANCA)-related vasculitis, which usually presents as renal pulmonary syndrome. It is defined as a pauci-immune necrotizing small vessel vasculitis, which usually affects the kidneys, followed by the lungs. It also presents systemic symptoms. The etiology of MPA is still unclear, but evidence reinforces the autoimmune mechanisms as the main etiopathogenic factor. Aortic valve stenosis (AS) is not an uncommon disease whose etiology varies according to geographical differences and the patient's age. The natural history of AS begins with a prolonged asymptomatic period, but when symptomatic, respiratory failure is one of its main clinical presentations. The authors present the case of a 55-year-old woman who was admitted with the diagnosis of renal failure, anemia, and a cardiac murmur. The patient had been recently diagnosed with pneumonia. During hospitalization, diagnostic workup disclosed a normal kidney size as well as parenchymal thickness. A renal biopsy was undertaken but the specimen was exiguous, showing 4 sclerotic glomeruli and 1 glomerulus with crescentic glomerulonephritis. The search for ANCA was positive. The investigation of the cardiac murmur disclosed AS. The patient, on hemodialysis, presented episodes of respiratory failure, which was interpreted as acute pulmonary edema, but a suspicion of ANCA-related pulmonary renal syndrome was raised. However, the aortic valve replacement was prioritized. While awaiting cardiac surgery, the patient died because of respiratory insufficiency. Autopsy findings concluded that MPA with pulmonary hemorrhage due to vasculitis was the immediate cause of death. Although AS was present at autopsy and classified as moderate/severe, this lesion was a bystander in the process of this patient's end of life, demonstrating the value of autopsy for medical learning and reasoning purposes.

  13. Aortic stenosis concomitant with microscopic polyangiitis: a challenge in medical reasoning and thinking

    Directory of Open Access Journals (Sweden)

    Paulo Sampaio Gutierrez

    2014-03-01

    Full Text Available Microscopic polyangiitis (MPA is part of the anti-neutrophil cytoplasmic antibodies (ANCA-related vasculitis, which usually presents as renal pulmonary syndrome. It is defined as a pauci-immune necrotizing small vessel vasculitis, which usually affects the kidneys, followed by the lungs. It also presents systemic symptoms. The etiology of MPA is still unclear, but evidence reinforces the autoimmune mechanisms as the main etiopathogenic factor. Aortic valve stenosis (AS is not an uncommon disease whose etiology varies according to geographical differences and the patient’s age. The natural history of AS begins with a prolonged asymptomatic period, but when symptomatic, respiratory failure is one of its main clinical presentations. The authors present the case of a 55-year-old woman who was admitted with the diagnosis of renal failure, anemia, and a cardiac murmur. The patient had been recently diagnosed with pneumonia. During hospitalization, diagnostic workup disclosed a normal kidney size as well as parenchymal thickness. A renal biopsy was undertaken but the specimen was exiguous, showing 4 sclerotic glomeruli and 1 glomerulus with crescentic glomerulonephritis. The search for ANCA was positive. The investigation of the cardiac murmur disclosed AS. The patient, on hemodialysis, presented episodes of respiratory failure, which was interpreted as acute pulmonary edema, but a suspicion of ANCA-related pulmonary renal syndrome was raised. However, the aortic valve replacement was prioritized. While awaiting cardiac surgery, the patient died because of respiratory insufficiency. Autopsy findings concluded that MPA with pulmonary hemorrhage due to vasculitis was the immediate cause of death. Although AS was present at autopsy and classified as moderate/severe, this lesion was a bystander in the process of this patient’s end of life, demonstrating the value of autopsy for medical learning and reasoning purposes.

  14. Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis

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    Roman Zuckerman

    2018-05-01

    Full Text Available Abstract Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN since the 1950s. While it is well known to cause drug-induced lupus (DIL, recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA associated vasculitis (DIV. Herein, we describe two patients (aged 57 and 87 years who presented with severe acute kidney injury (AKI, proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension. ANCA serology was positive in both patients along with anti-histone antibodies (commonly seen in drug-induced vasculitis. Renal biopsy revealed classic crescentic (pauci-immune glomerulonephritis in these patients and hydralazine was discontinued. During the hospital course, the 57-year-old patient required dialysis therapy and was treated with steroids and rituximab for the ANCA disease. Renal function improved and the patient was discharged (off dialysis with a serum creatinine of 3.6 mg/dL (baseline = 0.9 mg/dL. At a follow-up of 2 years, the patient remained off dialysis with advanced chronic kidney disease (CKD (stage IIIb. The 87-year-old patient had severe AKI with serum creatinine at 10.41 mg/dL (baseline = 2.27 mg/dL. The patient required hemodialysis and was treated with steroids, rituximab, and plasmapheresis. Unfortunately, the patient developed catheter-induced bacteremia and subsequently died of sepsis. Hydralazine can cause severe AKI resulting in CKD or death. Given this extremely unfavorable adverse-event profile and the widespread availability of alternative anti-hypertensive agents, the use of hydralazine should be carefully considered.

  15. Renal histology in the elderly: indications and outcomes.

    LENUS (Irish Health Repository)

    2012-02-01

    Background: Renal disease is being increasingly diagnosed in the elderly. However, reports on biopsy-confirmed renal disease in this population are limited. The aim of this study was to give an overview of the most important indications, diagnoses and outcomes of renal biopsies in the elderly in our center. Methods: This was a retrospective review of all elderly renal biopsies over 5 years. Patients were eligible for inclusion if they were aged =65 years and had had a native kidney biopsy performed. The data recorded included age, sex, indications for biopsy, histological diagnoses and outcomes. Results: During this time, 1,372 native renal biopsies were performed. Of these, 236 (17%) were in patients aged =65 years; 150 male (64%) and 86 female (36%). The most common indications for biopsy were acute renal failure and nephrotic syndrome. Common diagnoses included pauci-immune crescentic glomerulonephritis, tubulointerstitial nephritis, membranous nephropathy, IgA nephropathy and chronic thrombotic microangiopathy. Long-term follow-up of 3 years was available for 102 patients; median serum creatinine at the time of biopsy was 427 micromol\\/L (interquartile range 204-702) and at 3 years post biopsy had fallen to 192 micromol\\/L (interquartile range 152-408). Conclusions: In our center, 17% of native kidney biopsies are performed in elderly patients aged =65 years. In our experience, this procedure was safe and had a 97% diagnostic rate. The available follow-up data of patients suggest that renal histology is not only of benefit in diagnosis but also of potential value in terms of prognosis and treatment.

  16. Efeito da adição de níveis crescentes de polpa cítrica sobre a qualidade fermentativa e o valor nutritivo da silagem de capim-elefante Effect of increasing levels of citrus pulp on the fermentation quality and nutritive value of elephantgrass silage

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Mazza Rodrigues

    2005-08-01

    Full Text Available Foram estudados os efeitos da adição de polpa cítrica sobre a qualidade fermentativa e o valor nutritivo da silagem de capim-elefante. O capim-elefante, apresentando 90 dias de crescimento, foi ensilado com níveis crescentes de polpa cítrica peletizada: 0; 2,5; 5; 7,5; 10; 12,5 e 15%, com base na matéria fresca. As silagens foram produzidas em 28 silos experimentais (quatro repetições/tratamento, confeccionados a partir de baldes plásticos com válvulas do tipo Bunsen. A abertura dos silos ocorreu 106 dias após a ensilagem, quando foram determinados os teores dos ácidos orgânicos e a composição químico-bromatológica das silagens. Foi observado efeito linear crescente da adição de polpa cítrica sobre os teores de matéria seca, o mesmo ocorrendo para carboidratos solúveis e digestibilidade in vitro da matéria seca, mas com redução nos teores de nitrogênio amoniacal e fibra em detergente neutro. Para os teores de ácidos orgânicos (acético, lático e butírico e etanol, observou-se comportamento quadrático para as curvas obtidas, com pontos de máxima para o ácido lático igual a 5,8% e de mínima para os ácidos acético, butírico e o etanol, iguais a 7,8; 7,2; e -3,7% de polpa, respectivamente. Não foram observados efeitos sobre os valores de pH, assim como para os teores de lignina e de ácido propiônico. Inclusões de 4,7 a 7,6% de polpa cítrica peletizada, com base na matéria fresca, são suficientes para melhorar a qualidade e o valor nutritivo da silagem de capim-elefante.The effects of increasing levels of citrus pulp on fermentation pattern and nutritive value of elephantgrass silage was evaluated. Elephantgrass harvested at 90 days was ensiled with increasing levels of dried citrus pulp: 0, 2.5, 5, 7.5, 10, 12.5 and 15% (fresh matter basis. Silages were produced in 28 plastic experimental silos (4 replicates/treatment bearing Bunsen valves. Silos were opened 106 days after ensiling, when samples were

  17. Efeitos de doses crescentes de calcário em solo Latossolo Amarelo na produção de mudas de pau-de-balsa (Ochroma lagopus sw., bombacaceae Effects of the rising heat in Yellow Oxisoil in the production of silent wood rafts (Ochroma lagopus sw., bombacaceae

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Franco Tucci

    2010-09-01

    Full Text Available A produção de mudas de qualidade com adequado teor nutricional é fundamental para o desenvolvimento da planta e para a formação do sistema radicular, a qual apresentará melhor capacidade de adaptação ao novo local após o plantio. O objetivo deste trabalho foi avaliar o efeito de níveis crescentes de calcário na produção de mudas de pau-de-balsa. Os tratamentos foram constituídos de doses crescentes de corretivo e equivaleram a 0,0; 0,25; 0,5; 0,75; 1,0; 1,5 e 2,0 t ha-1 de calcário e o delineamento experimental utilizado foi o de blocos casualizados com cinco repetições. As características avaliadas foram: altura da planta; diâmetro do colo, matéria seca da parte aérea, matéria seca total, relação raiz/parte aérea, teores totais de macronutrientes nas plantas (N, P, K, Ca, Mg e S. Os resultados demonstraram que a prática de calagem como fator de correção do solo usado no substrato favoreceu todas as características de crescimento avaliadas na produção de mudas de pau-de-balsa. A correção do solo influenciou positivamente a absorção de Ca, Mg e S, por outro lado, não apresentou efeitos estatisticamente significativos para a absorção de N, P e K.The production of quality rafts with appropriate nutritional tenor is fundamental for plant development and for forming of root systems, which present best ability to adapt to new locations after plantation. The goal of this work was to evaluate the effect of rising heat levels in the production of silent wood rafts. The treatment was constituted by rising doses of correction and was equal to 0.0; 0.25; 0.5; 0.75; 1.0; 1.5, and 2.0 t ha-1 of lime and the experimental detail used was of blocks, repeating five times. The characteristics evaluated were: plant height; diameter, dry material of the aerial part, root relation/aerial part, content of macronutrients in the plants (N, P, K, Ca, Mg and S. The results demonstrate that the practice of liming as a soil correction

  18. Risco crescente de melanoma de pele no Brasil

    Directory of Open Access Journals (Sweden)

    Guinar Azevedo e Silva Mendonça

    1992-08-01

    Full Text Available A ocorrência de melonoma maligno de pele no Brasil é analisada a partir dos dados de mortalidade disponíveis no Ministério da Saúde e dos dados de incidência dos seis Registros de Câncer de Base Populacional, localizados em seis capitais brasileiras. Os coeficientes de incidência nessas capitais situam-se em padrões intermediários se comparadas às cifras mundiais. Para o Município de Porto Alegre, uma das capitais estudas, que apresentou os maiores coeficientes de incidência, é feita comparação entre os dados relativos ao período 1979-1982 e 1987, constatando-se que houve aumento relativo de 38% entre homens e de 11% entre mulheres. Concluiu-se pela necessidade de se conduzir estudos no Brasil entre comunidades de indivíduos de pele clara, os quais apresentam risco potencializado para o desenvolvimento de melanoma, para que sejam definidas medidas específicas e eficazes de controle.

  19. soil failure crescent radii measurement for draft in tillage study

    African Journals Online (AJOL)

    user

    1986-09-01

    Sep 1, 1986 ... SCHOOL OF ENGINEERING AND ENGINEERING TECHNOLOGY. FEDERAL UNIVERSITY OF TECHNOLOGY. OWERRI. ABSTRACT. Field clay loam and sandy loam soils were tilled with a chisel .... modified earth moving equation proposed by Mckyes and All was: ... applications of analytical mechanics.

  20. Regimes de financiamento, risco crescente do endividamento e fragilidade financeira

    Directory of Open Access Journals (Sweden)

    Gilberto Tadeu Lima

    2005-06-01

    Full Text Available Elabora-se um modelo macroeconômico de curto prazo na tradição pós-keynesiana, no qual a oferta de crédito é endógena e o grau de endividamento das firmas é explicitamente modelado. Relacionam-se as condições de vigência dos regimes minskyanos de financiamento - hedge, especulativo ou Ponzi - não somente ao grau de endividamento e à taxa de juros, mas, inclusive, aos parâmetros da função investimento desejado da firmas e à propensão a poupar dos capitalistas produtivos e financeiros.It is developed a short-run macromodel in the post-keynesian tradition, in which credit supply is endogenous and firms' debt position is explicitly modeled. The conditions under which each one of the minskyan financing regimes will prevail are related not only to the degree of indebtedness and the level of interest rate, but also to the parameters of firms' desired investment function and the saving propensity of productive and financial capitalists.

  1. International Federation of Red Cross and Red Crescent Societies

    Science.gov (United States)

    ... News | Contact us | Sitemap English | français | español | العربية IFRC.org FedNet DMIS Who we are History Our vision ... News | Contact us | Sitemap English | français | español | العربية IFRC.org FedNet DMIS You are here: Home Text size: - ...

  2. Crescent Evaluation : appendix B : state case study evaluation report

    Science.gov (United States)

    1994-02-01

    The state case study evaluation approach uniquely captured an understanding of the potential of such a system by documenting the experiences, issues, and opportunities of selected key state government personnel from a cross-section of involved agenci...

  3. Desempenho produtivo, composição corporal e parâmetros fisiológicos de pacu alimentado com níveis crescentes de fibra Productive performance, body composition and physiological parameters of pacu fed increasing levels of fiber

    Directory of Open Access Journals (Sweden)

    Laurindo André Rodrigues

    2010-08-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de teores de fibra bruta na dieta sobre o desempenho produtivo, composição centesimal da carcaça e parâmetros fisiológicos de juvenis de pacu. O experimento teve duração de 84 dias, e foram utilizados 360 juvenis de pacu, com peso médio de 23,97±0,59 g, distribuídos aleatóriamente em 30 tanques com 180 L de água, em delineamento inteiramente casualizado, com seis tratamentos (5, 7, 9, 11, 13 e 15% de fibra bruta e cinco repetições. Dietas com altos teores de fibra (11, 13 e 15% resultaram em piores taxas de ganho de peso, conversão alimentar e crescimento específico, além de menor eficiência proteica e consumo de ração. A composição da carcaça dos animais foi alterada pelo aumento do teor de fibra das dietas. Os teores de proteína e cinza tiveram aumento com o incremento nos teores de fibra. O metabolismo foi alterado com o emprego de teores crescentes de fibra, o que resultou em pequena elevação do colesterol plasmático. Teores de fibra bruta de até 9% não tiveram efeitos negativos no metabolismo; entretanto, teores acima de 11% reduziram o crescimento dos peixes.The objective of this work was to evaluate the effects of dietary crude fiber contents on productive performance, carcass composition and physiological parameters of pacu juveniles. The experiment was carried out during 84 days, 360 pacu juveniles were used with mean weight 23.97±0.59 g, stocked in 30 tanks with 180 L of water, in a completely randomized design, with six treatments (5, 7, 9, 11, 13 and 15% crude fiber and five replicates. Diets with high fiber contents (11, 13 and 15% resulted in worse rates of weight gain, feed conversion, and specific growth, besides lower protein efficiency ratio and feed consumption. Carcass composition changed by increasing the contents of dietary fiber. Body contents of protein and ash increased along with the fiber levels. The metabolism changed with the use of

  4. Digestibilidade e tempo de trânsito gastrintestinal de dietas contendo níveis crescentes de fibra bruta para pacu - doi: 10.4025/actascianimsci.v32i2.8625 Digestibility and gastrointestinal transit time of diets with increasing dietary fiber levels to pacu - doi: 10.4025/actascianimsci.v32i2.8625

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    Thiago Matias Torres Nascimento

    2010-07-01

    Full Text Available O objetivo deste trabalho foi avaliar a digestibilidade e o tempo de trânsito gastrintestinal (TTGI de dietas contendo níveis crescentes de fibra bruta (FB para pacus. Para avaliar a digestibilidade foram utilizados 288 pacus, em delineamento inteiramente casualizado, alimentados em aquários e transferidos para coletores do tipo Guelf Modificado, utilizando-se o método de coleta parcial de fezes. As rações foram marcadas com 1% de óxido de crômio para a determinação da digestibilidade das dietas. No ensaio de TTGI, 288 pacus foram distribuídos em 24 aquários em delineamento inteiramente casualizado e alimentados com rações contendo 1% óxido de titânio ou crômio, que apresentam cores diferentes, verde ou branca, respectivamente. Por meio de massagem abdominal foi averiguada periodicamente a cor das fezes, e o TTGI foi estabelecido quando as fezes de todos os peixes apresentaram cor verde. Os coeficientes de digestibilidade aparente das dietas e o TTGI foram reduzidos com aumento do nível de FB nas dietas. Conclui-se que em dietas para pacus pode-se empregar até 9% de FB sem efeito negativo na digestibilidade da energia, proteína, matéria seca e estrato etéreo e sem alterar o TTGI.This work aimed to evaluate the effect of increasing dietary fiber levels on the digestibility and gastrointestinal transit time (GTT for pacu. The digestibility trial used 288 pacu in a completely randomized design, fed in aquaria and transferred to a modified Guelf-type feces collector, using the partial sampling method. The inert marker on the diets was chromic oxide (1% to establish the diet digestibility. In the GTT assay, 288 pacu were distributed in 24 aquaria in a completely randomized design. Fish were fed with two colored diets – green and white – and feces color was determined after abdominal pressure. The white and green diets used 1% of titanium and chromic oxides, respectively. Total GTT was determined when all fish showed green

  5. Níveis crescentes de parede de levedura sobre a resposta imune celular e perfil hematológico de frangos de corte Cellular immune response and hematological parameters of broilers from different age broiler breeders, fed with a sorghum meal with different yeast wall levels

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    Suelen Regina Ferreira

    2009-09-01

    Full Text Available Um experimento foi conduzido para avaliar o efeito de níveis crescentes de parede de levedura e idade das matrizes reprodutoras sobre o peso dos órgãos linfóides, a resposta imune celular e o perfil hematológico de frangos de corte. Foram utilizados 3.360 pintos de corte da linhagem Cobb, distribuídos em delineamento inteiramente casualisado, em esquema fatorial 2x5, mais dois controles, sendo duas idades de matrizes (34 e 57 semanas de idade e cinco níveis de suplementação de parede de levedura (zero, um, dois, três e quatro kg de parede de levedura/tonelada de ração. A idade das matrizes influenciou a resposta de todas as variáveis. A inclusão de 3kg de parede de levedura/tonelada de ração promoveu, na progênie de reprodutoras de 57 semanas, reação inflamatória mais intensa quando comparada a dieta controle, no entanto não houve aumento significativo no número de heterófilos e linfócitos circulantes. Conclui-se que a utilização da parede de levedura associada ao sorgo ou não em rações de frangos de corte ainda necessita de estudos complementares, que incluam, por exemplo, os componentes purificados da parede de levedura (MOS e ß-glucano.An experiment was carried out to evaluate the effect increasing levels of yeast wall and broiler breeders' age levels on lymphoid organs weight, cellular immune response and hematological parameters in broilers. A total of 3,360 Cobb broilers were allotted, in a completely randomized design and a 2x5 factorial arrangement, and two controls, compound of two broiler breeders age (34 and 57 weeks of age and five yeast wall levels (zero, one, two, three and four kg of yeast wall/ton of diet. Broiler breeders' age affected all studied variables. The inclusion of 3kg of yeast wall/ton of meal increased, at 57 weeks age broiler breeders, more intense inflammatory reaction when compared to control diet; however the circulated heterophils and lymphocytes numbers were not increased. In

  6. Produtividade do Capim-Cameroon estabelecida em duas classes de solos e submetido a doses crescentes de nitrogênio no norte tocantinense = Production of Cameroon grass in two soil classes with increasing nitrogen levels in the north of Tocantins State, Brazil

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    Rossini Sôffa da Cruz

    2010-10-01

    Full Text Available Este estudo foi desenvolvido com o objetivo de avaliar o capim-elefante cv. Cameroon em função de doses de N em diferentes solos. Foi utilizado o delineamento experimental inteiramente casualizado em fatorial 5 x 2, sendo cinco doses de nitrogênio (0, 30, 60, 90, e 150 kg de N ha-1, testadas em duas classes de solo (Argissolo Vermelhoeutroférrico típico e Neossolo Quartzarênico órtico típico, com quatro repetições. Os parâmetros avaliados foram: altura da planta, perfilhos, massa por perfilho, relação folha: colmo, matéria seca e pH do solo. Houve resposta positiva para ambos os solos, sendo amelhor resposta para o Argissolo. A massa dos perfilhos em gramas mostra efeito linear em função dos níveis de N e no Neossolo não houve diferença entre os tratamentos. O aumento da massa individual de perfilhos teve maior efeito na massa seca total. A adubaçãoN promoveu acidificação linear decrescente maior no Argissolo. O desenvolvimento do capim, em função dos níveis crescentes de N apresentou resposta positiva para ambos os solos, sendo melhor para o Argissolo em comparação ao Neossolo.The development of elephant grass at increasing nitrogen rates in two soil classes was evaluated. A totally randomized 5 x 2 design, with five nitrogen levels (0, 30, 60, 90, and 150 kg N ha-1, in two classes of soil (Oxisol and Entisol, with four repetitions, was employed. Evaluated parameters consisted of plant height, tillers, mass per tiller, leaf:stem ratio, dry matter and pH of soil. Althoughthe production of Pennisetum purpureum was positive for both types of soil, best response occurred in Oxisol. Whereas mass (in grams of the tillers had a linear effect according to nitrogen rates, there was no difference between treatments in Entisol. Increase of tillers’mass had the highest effect on total dry mass. Nitrogen fertilization promoted highest decreasing acidification in Ultisol. Due to increasing levels of nitrogen the development of

  7. Influência de doses crescentes de chumbo sobre o teor e o conteúdo de nutrientes e Pb em mudas de ipê-roxo (Tabebuia impetiginosa (Mart. Standl. Influence of increasing lead levels on nutrient and Pb content and accumulation in ipê-roxo (Tabebuia impetiginosa (Mart. Standl. seedlings

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    Haroldo Nogueira de Paiva

    2003-04-01

    Full Text Available O efeito da aplicação de chumbo sobre o teor e o conteúdo de nutrientes e Pb na raiz, no caule e nas folhas de mudas de ipê-roxo (Tabebuia impetiginosa (Mart. Standl. foi estudado em um experimento realizado em casa de vegetação do Departamento de Ciência do Solo da Universidade Federal de Lavras. As mudas foram cultivadas em solução nutritiva de Clark e submetidas a doses crescentes de Pb: 0, 48, 96, 192 e 288 mimol/l. O experimento foi conduzido em delineamento estatístico de blocos ao acaso, e após 60 dias de exposição ao metal pesado foram feitas avaliações do teor e do conteúdo de macro, micronutrientes e chumbo na matéria seca de raiz, caule e folha. Os resultados mostraram que a aplicação de chumbo aumentou o teor de P e praticamente não afetou os teores de S, Ca e Mg nas mudas. De modo geral os teores de Cu, Fe e Mn sofreram redução, o teor de Zn não foi afetado, enquanto o conteúdo de macro e de micronutrientes sofreu redução. O teor de Pb na matéria seca de raiz, caule e folha aumentou com as doses aplicadas, principalmente na raiz, e se mostrou pouco móvel nas plantas analisadas.The effect of lead application on nutrient and Pb content and accumulation in ipê-roxo (Tabebuia impetiginosa (Mart. Standl. seedlings was studied in an experiment conducted under greenhouse conditions at the Soil Science Department of the Federal University of Lavras. The seedlings were cultivated in Clark nutrient solution and submitted to increasing Pb levels: 0, 48, 96, 192 and 288 mumol/l. The experiment was arranged in a randomized block design and after 60 days of exposure to the heavy metals, evaluations of macro and micronutrient and lead content and accumulation in the root, stem and leaf dry matter were made. The results showed that lead application increased P content and practically did not affect S, Ca and Mg contents. Cu, Fe and Mn contents, in general, presented a reduction; Zn content was not affected while macro

  8. Modelos matemáticos para o estudo do fluxo biológico do fósforo em suínos alimentados com dietas suplementadas com níveis crescentes de fitase Mathematical models for the study of the biological flow of phosphorus in pigs fed with diets containing increasing levels of phytase

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    J.A. Moreira

    2009-04-01

    Full Text Available A pesquisa foi realizada para avaliar o fluxo biológico do fósforo entre os compartimentos, fisiológicos ou anatômicos, de suínos mantidos em dietas que continham níveis crescentes de fitase, usando o P-32 como traçador. O delineamento experimental foi inteiramente ao acaso, sendo os tratamentos constituídos por níveis de enzima fitase, 253, 759, 1265 e 1748 UF/kg, nas dietas. As variáveis avaliadas foram: ingestão, excreção, atividades específicas e fluxo de P nos compartimentos (trato digestivo, corrente sanguínea, tecidos moles e ossos. A enzima fitase não interferiu nas excreções fecais e urinárias, nas atividades específicas, na incorporação e na reabsorção de P nos ossos e nos tecidos moles e no fluxo bidirecional do trato digestivo e na corrente sanguínea, mas afetou linearmente a absorção e a retenção nos ossos. As respostas mais evidentes dos efeitos da adição da fitase são observadas nos níveis mais baixos.The biological flow of P was evaluated among the physiologic or the anatomical compartments of pigs fed diets with increasing phytase levels, using P-32 as tracer. The experimental design was completely randomized. Treatments consisted of phytase levels in diets (253, 759, 1265, and 1748UF/kg. The evaluated variables were: feed intake, excretion, specific activities and flow of P in the compartments (gut, blood, bone, and soft tissus. Phytase level did not interfere with fecal and urinary excretion, specific activities, incorporation and resorption of bone, and soft tissue P and in the bidirectional flow of gut and blood, but linearly affected P absorption and bone P retention. The best response was observed with the lowest phytase levels.

  9. Desempenho e peso de frações corporais, na suplementação crescente de lisina, dos 19 aos 40 dias de idade em frangos de corte Performance and weight of body components of broilers supplemented with increasing lysine levels from 19 to 40 days of age

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    Teresa Herr Viola

    2009-04-01

    Full Text Available Este estudo foi conduzido para avaliar o desempenho e o peso das frações corporais de frangos de corte, recebendo dietas com níveis crescentes de lisina digestível (Lis dig (0,70; 0,80; 0,90; 1,00; 1,055; 1,11; 1,165 e 1,22%. Foram utilizados 320 frangos machos da linhagem CobbXCobb500, dos 19 aos 40 dias de idade. Foram utilizadas duas dietas basais, com 19,0 e 20,5% de proteína bruta; a primeira para os quatro níveis mais baixos de Lis dig e a segunda, para os quatro restantes. As dietas foram formuladas de forma a manter constante a relação de aminoácidos digestíveis Met, Arg e Tre com a Lis dig. Foram avaliados o peso médio, o ganho de peso, o consumo de ração, o consumo de lisina e a conversão alimentar aos 26, 33 e 40 dias de idade. Também nessas idades, o peso das frações corporais, carcaça, peito, coxa, perna, dorso+asa+pescoço+cabeça+patas +gordura abdominal (D+A, vísceras+sangue (V+S e penas foi determinado. O ganho de peso e a conversão alimentar apresentaram respostas lineares positivas em função dos níveis de Lis dig. Já o consumo de ração não foi influenciado pelos tratamentos. As respostas das frações corporais foram lineares crescentes para peso do peito e da carcaça, em todos os períodos avaliados (26, 33 e 40 dias, com níveis ótimos de Lis dig ≥1,22%. A mesma resposta se deu para peso da coxa aos 26 e 40 dias, para D+A, aos 33 e 40 dias e para peso de perna, aos 26 e 33 dias, enquanto, para peso de perna, aos 40 dias, a resposta foi quadrática, ainda que com nível ótimo de Lis dig. ≥1,22%. Sugere-se que níveis mais elevados de lisina digestível, nas dietas de frangos machos da linhagem Cobb500, sejam estudados.This study was conducted to evaluate broiler growth performance and body fraction weights , in response to increasing levels of dietary digestible lysine (dig Lys (0.70, 0.80, 0.90, 1.00, 1.055, 1.11, 1.165 and 1.22%. Three hundred and twenty male broilers CobbXCobb500 were used

  10. Disease: H01655 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available nulomatous inflammation and pauci-immune small- vessel vasculitis of upper and lower respiratory tract and kidneys. The discovery...syndromes. Pr3-ANCA is the predominant autoantibody found in patients with GPA. The discovery of ANCA has ma

  11. Peso e rendimento dos componentes do peso vivo de cordeiros terminados em confinamento com dietas contendo proporções crescentes de resíduo úmido de cervejaria Weight and yield of liveweight components of feedlot finish lambs fed diets with increasing proportions of wet brewery residue

    Directory of Open Access Journals (Sweden)

    M.A. Brochier

    2008-10-01

    Full Text Available Avaliou-se o efeito de dietas contendo proporções crescentes de resíduo úmido de cervejaria sobre o peso e proporção dos componentes do peso vivo de cordeiros terminados em confinamento. Foram utilizados 25 cordeiros, machos, não-castrados, da raça Texel, distribuídos aleatoriamente em cinco tratamentos compostos por proporções de 0%, 25%, 50%, 75% e 100% de substituição do alimento concentrado por resíduo úmido de cervejaria. Utilizou-se dieta composta de feno de Tifton-85 e mistura concentrada em uma relação volumoso:concentrado de 40:60, na matéria seca. O alimento concentrado foi constituído por milho desintegrado, farelo de soja, mistura mineral e resíduo úmido de cervejaria, sendo que suas proporções variaram de acordo com os tratamentos. Houve redução linear dos pesos de sangue, patas, cabeça, fígado, pulmão e baço, e da proporção de fígado, à medida que se elevou a proporção do resíduo úmido de cervejaria nas dietas. A proporção, em relação ao peso vivo, de rúmen/retículo e do trato gastrintestinal, com conteúdo, e do conteúdo gastrintestinal aumentou linearmente, enquanto os pesos de rúmen/retículo, abomaso, intestino delgado e do trato gastrintestinal, sem conteúdo, diminuíram linearmente com o aumento da proporção do resíduo nas dietas. A proporção de rúmen/retículo, sem conteúdo, foi influenciada de forma quadrática.The effect of diets with increasing proportions of wet brewery residue on the weight and proportion of live weight components of feedlot finished lambs was evaluated. Twenty-five non-castrated Texel male lambs were randomly allotted into five groups, consisting in the replacement of the concentrate by wet brewery residue; at the proportions of 0%, 25%, 50%, 75%, and 100%. Diet composition was Tifton-85 hay and concentrate mixture, in a relation roughage:concentrate of 40:60, based on dry matter (DM. The concentrate was composed of ground corn, soybean meal, mineral

  12. Produção e composição químico-bromatológica da aveia preta fertilizada com doses crescentes de dejeto líquido suíno Production and chemical composition of the common black oats fertilized with growing doses of liquid swine manure

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    Daniela Mondardo

    2011-06-01

    Full Text Available O trabalho teve como objetivo avaliar o efeito da aplicação de doses crescentes de dejeto líquido suíno sobre a produção e composição químico-bromatológica da parte aérea da aveia preta. O experimento foi conduzido em sistema de plantio direto sob o delineamento em blocos casualizados com quatro repetições e os tratamentos constituídos pela aplicação de 0; 10; 20; 30; 40 e 50 m³ ha-1 de dejeto líquido suíno. Foram determinados a produção de MS da parte aérea, a relação folha:colmo e os teores de proteína bruta (PB, fibra em detergente ácido (FDA, fibra em detergente neutro (FDN, matéria mineral (MM, matéria orgânica (MO, nitrogênio (N, fósforo (P, potássio (K, cálcio (Ca, magnésio (Mg, cobre (Cu, zinco (Zn, manganês (Mn e ferro (Fe. A aplicação de dejeto líquido suíno não promoveu efeitos significativos sobre a produção de MS e teores de FDN, MM e MO, mas promoveu aumento linear da relação folha:colmo e do teor de PB e redução linear no teor de FDA. Quanto aos minerais, as doses de dejeto líquido suíno promoveram aumento linear nos teores de N, P, K, Ca e Zn, sem efeitos sobre os demais minerais estudados. A utilização de dejeto líquido suíno na fertilização da cultura da aveia até a dose de 50 m³ ha-1 não aumenta a produção de forragem mas eleva o valor nutricional.The work has as objective evaluate the effect of application of increasing doses of pig slurry under yield and chemical composition of black oat shoot. The experiment was carried out in no-tillage system under experimental design of randomized blocks with four replications and the treatments composed by application of 0; 10; 20; 30; 40; 50 m³ ha-1 of pig slurry. Were determined the yield of total dry mass, the leaf-stem ratio and content of crude protein (CP, acid detergent fiber (ADF, neutral detergent fiber (NDF, mineral matter (MM, organic matter (OM, nitrogen (N, phosphorus (P, potassium (K, calcium (Ca, magnesium (Mg

  13. Efeito de níveis crescentes de uréia na dieta de vacas em lactação sobre a produção e a composição físico-química do leite Effect of increasing dietary urea levels on milk yield and composition of lactating cows

    Directory of Open Access Journals (Sweden)

    Adriana Augusto Aquino

    2007-08-01

    Full Text Available Avaliou-se o efeito de níveis crescentes de uréia na dieta de vacas em lactação sobre a produção e composição físico-química do leite. Foram utilizadas nove vacas holandesas em lactação, distribuídas em três quadrados latinos 3 x 3, com três tratamentos e três períodos de coleta. O experimento teve duração de 63 dias, divididos em três períodos de 21 dias. Os tratamentos consistiram de uma dieta controle, formulada para suprir 100% das exigências de PB, proteína degradável no rúmen (PDR e proteína não-degradável no rúmen (PNDR, composta de farelo de soja como principal fonte protéica e cana-de-açúcar como volumoso, e de duas outras dietas, semelhantes à dieta controle, mas com 0,75 ou 1,5% de uréia em substituição ao farelo de soja. As dietas foram isoenergéticas (1,53 Mcal/kg de energia líquida de lactação e isoprotéicas (16% de PB. Quando os resultados foram analisados por regressão polinomial simples, não houve efeitos das dietas sobre o consumo de MS, as produções de leite e de leite corrigida para 3,5% de gordura, os teores de proteína e gordura e a contagem de células somáticas do leite. Os níveis de substituição do farelo de soja por uréia não influenciaram o pH, a crioscopia ou a densidade do leite. No entanto, verificou-se efeito linear decrescente dos níveis de uréia na dieta sobre a acidez do leite. Os teores de proteína, gordura, lactose, uréia, extrato seco total e extrato seco desengordurado não foram afetados pelas dietas. Os resultados deste estudo sugerem que o uso de até 1,5% de uréia na MS da dieta de vacas em lactação não altera a produção, a composição e as características físico-químicas do leite.The objective of this trial was to evaluate the effects of three different dietary levels of urea on milk yield and composition. Nine lactating Holstein cows were randomly assigned to three replicated 3 x 3 Latin squares with three periods of 21 days each

  14. Efeitos de rações com níveis crescentes de cana-de-açúcar em substituição à silagem de milho sobre a população de protozoários ciliados no rúmen de ovinos Effects of diets with increasing levels of sugar cane in substitution of corn silage on rumen population ciliate protozoa in sheep

    Directory of Open Access Journals (Sweden)

    Maria Helena Tieghi Franzolin

    2000-10-01

    Full Text Available Oito ovinos machos com fístulas ruminais foram delineados em dois quadrados latinos, em quatro períodos de 35 dias cada e quatro tratamentos, compreendendo níveis crescentes de cana-de-açúcar (CA em substituição à silagem de milho (SM: A 100% SM; B 67% SM e 33% CA; C 33% SM e 67% CA; e D 100% CA, para avaliação da população de protozoários ciliados no rúmen. As concentrações totais de protozoários ciliados no rúmen e de Entodinium diminuíram e os valores de pH do conteúdo ruminal aumentaram linearmente com o incremento das quantidades de cana-de-açúcar na ração. Não houve diferenças entre tratamentos para o volume ruminal e a taxa de passagem da fase líquida do rúmen.Eight rumen fistulated rams were delineated in two Latin Squares in four periods of 35 days each and four treatments consisted of increasing levels of sugar cane (SC in substitution to the corn silage (CS: A 100% CS, B 67% CS and 33% SC, C 33% CS and 67% SC and D 100% SC, to evaluate the population of ciliate protozoa in the rumen. The total concentrations of rumen ciliate protozoa and of Entodinium decreased and the values of pH of the ruminal content increased linearly as dietary sugar cane levels increased. No differences between treatments were observed for the rumen volume and the rumen liquid turnover rate.

  15. Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report

    Directory of Open Access Journals (Sweden)

    Keasberry Justin

    2013-01-01

    Full Text Available Abstract Introduction Anti-neutrophil cytoplasmic antibody-associated vasculitis has been associated with many drugs and it is a relatively rare side effect of the antihypertensive drug hydralazine. The diagnosis and management of patients who have anti-neutrophil cytoplasmic antibody-associated vasculitis may be challenging because of its relative infrequency, variability of clinical expression and changing nomenclature. The spectrum of anti-neutrophil cytoplasmic antibody-associated vasculitis is wide and can be fatal. This case documents a 62-year-old woman who presented with hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis with a puzzling cutaneous rash. Case presentation We report a rare case of hydralazine-induced anti-neutrophil cytoplasmic antibody-associated vasculitis in a 62-year-old Caucasian woman who presented with a vasculitic syndrome with a sore throat, mouth ulcers and otalgia after several months of constitutional symptoms. She then proceeded to develop a rash over her right lower limb. Clinically, the rash had features to suggest Sweet’s syndrome, but also had some appearances consistent with embolic phenomena and did not have the appearance of palpable purpure usually associated with cutaneous vasculitis. Differential diagnoses were hydralazine-associated Sweet’s syndrome, streptococcal-induced cutaneous eruption or an unrelated contact dermatitis. A midstream urine sample detected glomerular blood cells in the setting of anti-neutrophil cytoplasmic antibody-positive renal vasculitis and Streptococcus pyogenes bacteremia. A renal biopsy revealed a pauci-immune, focally necrotizing glomerulonephritis with small crescents. Her skin biopsy revealed a heavy neutrophil infiltrate involving the full thickness of the dermis with no evidence of a leucocytoclastic vasculitis, but was non-specific. She was initially commenced on intravenous lincomycin for her bloodstream infection and subsequently

  16. Balanço de nitrogênio e perdas endógenas em bovinos e bubalinos alimentados com níveis crescentes de concentrado - DOI: 10.4025/actascianimsci.v29i4.1012 Nitrogen balance and endogenous losses in cattle and buffaloes fed with increasing levels of concentrate - DOI: 10.4025/actascianimsci.v29i4.1012

    Directory of Open Access Journals (Sweden)

    Ângela Maria Vieira Batista

    2008-03-01

    Full Text Available O trabalho objetivou avaliar as concentrações de uréia plasmática e urinária; o balanço dos compostos nitrogenados e estimar as exigências de proteína para mantença por equações preconizadas pelos sistemas americano e britânico, em quatro bovinos e quatro bubalinos, com peso médio inicial de 461,19 ± 7,59 e 455,44 ± 7,85 kg para os bovinos e búfalos, respectivamente, distribuídos em dois quadrados latinos 4 x 4. Os tratamentos consistiram em diferentes níveis de concentrado (0,0; 24,0; 48,0; 72,0% à base de milho moído, farelo de soja e sal mineral, e feno de capim-tifton. Cada período durou 21 dias, sendo 14 de adaptação e sete para coleta. Foram coletadas amostras de fezes e urina (spot para estimativa da produção de matéria seca fecal e volume urinário. Houve interação entre as espécies para nitrogênio (N consumido (NC, urinário (NU g kg-0,75 e uréia urinária (UU; não ocorrendo para N fecal (NF, N absorvido (NABS, NU (g d-1, balanço de N (BN e uréia plasmática (UP. Independente do efeito observado entre as espécies, as variáveis aumentaram linearmente em função dos níveis crescente de concentrado que proporcionou BN positivo. Os requerimentos de proteína metabolizável para mantença de bovinos e bubalinos, quando estimados por meio dos sistemas americano e britânico, são diferentes.The work aimed to evaluate the concentrations of plasmatic and urine urea, the balance of nitrogen compounds, and to estimate the protein requirements for maintenance. Equations recommended by the American and British systems were used in four bovine and four bubaline steers, with initial average weight of 461.19 ± 7.59 and 455.44 ± 7.85 kg for cattle and buffaloes, respectively, distributed into two 4 x 4 Latin squares. The treatments consisted of different levels of concentrate (0.0; 24.0; 48.0; and 72.0% composed of cracked corn, soybean meal, mineral salt, and Tifton-grass hay. Each period lasted 21 days, being

  17. Biodisponibilidade e perdas endógenas mínimas de P em dietas com níveis crescentes de fitase para suínos em crescimento pela técnica de diluição isotópica Bioavailability and minimum endogenous losses of P in diets with phytase increasing levels for growing swine by using the isotopic dilution technique

    Directory of Open Access Journals (Sweden)

    J.A. Moreira

    2003-06-01

    Full Text Available O objetivo do trabalho foi avaliar rações à base de milho, farelo de soja e farelo de arroz desengordurado contendo níveis crescentes de fitase (253, 759, 1265 e 1748 UF/kg de ração, por meio da biodisponibilidade e das perdas endógenas mínimas de P com o uso da técnica de diluição isotópica. Foram utilizados 20 suínos mestiços (machos castrados, com peso médio de 32,19+2,17 kg, em delineamento experimental de blocos ao acaso, contendo cinco tratamentos e quatro repetições. Os leitões foram mantidos em gaiolas metabólicas durante 10 dias para adaptação e sete dias para coletas de sangue, fezes e urina. No primeiro dia de coleta foram injetados em cada animal, por via endovenosa, 7,4 MBq de 32P. No final do experimento os animais foram abatidos e os tecidos do músculo, coração, fígado, rins e ossos coletados para estudos posteriores. Os níveis de enzima fitase não afetaram o P retido, o P urinário, o P plasma e a biodisponibilidade. Observou-se efeito quadrático dos níveis de fitase sobre o P nas fezes e endógeno. A variável perda endógena de fósforo foi mais precisa do que a variável biodisponibilidade para avaliar os efeitos da enzima fitase. O melhor aproveitamento do fósforo fítico ocorreu no nível 759 UF.The objective of this study was to evaluate diets containing increasing levels of phytase (253, 759, 1265 and 1748 PU/kg of diets, by mean of bioavailability and minimum endogenous P losses. Twenty crossbred barrow weighting 32.19+2.17 kg were used in a randomized block design experiment, with five treatments and four replicates. The animals were kept in metabolic cages for a ten-day adaptation period and seven days for total collection of feces and urine. Blood samples were taken for seven days. At the first day of the collection period, each animal was injected intravenously with 7.4 MBq of 32P. At the end of the experimental period the animals were slaughtered and tissues of the muscle, heart, liver

  18. Long-term Prognosis of Anti-Neutrophil Cytoplasmic Antibody-Negative Renal Vasculitis: Cohort Study in Korea.

    Science.gov (United States)

    Lee, Sung Woo; Yu, Mi-Yeon; Baek, Seon Ha; Ahn, Shin-Young; Kim, Sejoong; Na, Ki Young; Chae, Dong-Wan; Chin, Ho Jun

    2016-04-01

    Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5-2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Cox-proportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028-9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.

  19. Clinical outcomes in children with Henoch-Schönlein purpura nephritis without crescents.

    Science.gov (United States)

    Delbet, Jean Daniel; Hogan, Julien; Aoun, Bilal; Stoica, Iulia; Salomon, Rémi; Decramer, Stéphane; Brocheriou, Isabelle; Deschênes, Georges; Ulinski, Tim

    2017-07-01

    Henoch-Schönlein purpura is the most common vasculitis in children. Its long-term prognosis depends on renal involvement. The management of Henoch-Schönlein purpura nephritis (HSPN) remains controversial. This study reports the prognosis of children with HSPN presenting with class 2 International Study of Kidney Disease in Children (ISKDC) nephritis. All children with HSPN class 2 diagnosed between 1995 and 2015 in four pediatric nephrology centers were included, and clinical and biological data were collected from the medical files. The primary endpoint was proteinuria remission defined as a proteinuria 3 g/L, 52% proteinuria between 1 and 3 g/L, and 18% proteinuria <1 g/L. Forty-seven percent of patients received orally treatment with steroids alone, 37% received methylprednisolone pulses followed by steroids orally, 18% received no steroids. Although 85% reached remission during follow-up, 12% did not maintain complete remission over time so that only 75% remained in complete remission by the end of the follow-up. Univariate analysis found a higher likelihood of remission in patients with higher proteinuria at disease onset (p = 0.009). This trend was not found in the multivariate analysis after adjusting for treatments, as patients with higher proteinuria were most often treated with steroids. Our study shows that one fourth of patients with HSPN class 2 remain proteinuric and thus carry the risk of developing chronic kidney disease over the long term. This finding, together with the better outcome of patients treated with steroids, is in favor of using high-dose steroids orally or IV in these patients.

  20. Crescent City, California 1/3 Arc-second Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) for select U.S. coastal regions. These integrated...

  1. Crescent and Electoral Strength: Islamic Party Portrait of Reform Era In Indonesia

    Directory of Open Access Journals (Sweden)

    LILI ROMLI

    2013-12-01

    Full Text Available The establishment of Islamic political parties in the reform era in Indonesia after the fall of Suharto (1998, considered as resurgence of political stream. There are several factors that led to the revival of Islamic parties after the New Order, the theological factor, historical, sociological, and reform factor. The presence of Islamic political parties after the New Order was apparently diverse and fragmented. In the political elite of Islam itself in establishing a political party based on Islam and there is also based on nationality, and in establishing political party was using substantially approach and there is also that use formalistic approach. In the reform era elections, political Islam has failed, in which Islamic parties do not receive optimal support from voters Islam. The failure of Islamic parties in election of reform era is caused of factor among Muslims has been change the orientation of political views. Islamic parties in the reform era stuck in a political myth quantity, and Islamic parties are also fragmented and fractured in to small forces.

  2. The Shi’a Crescent: A Misconception of Shi’a Alliance

    Science.gov (United States)

    2014-12-01

    Iranian origin to Iran.33 After the Iraq-Iran War started, Saddam’s regime encouraged Iraqi men who were married to Iranian women to divorce their...region, indicating that “The Shi’a point to a pattern of negligence and poverty resulting from discriminatory practices of governments from Ottoman...decreased the authority of the sayyids, who were tribal counselors on marriages, divorces , and inheritances,26 and marked the success of the Sunni

  3. 78 FR 24717 - Crescent Ranger District; Deschutes National Forest; Klamath County, Oregon; Marsh Project...

    Science.gov (United States)

    2013-04-26

    ... natural and human threats to this current range of benefits being provided, and also enhance the ecosystem... Service road 5825-540 to the public; Remove approximately 65 acres of Invasive Reed Canary Grass; Thin...

  4. crescent_city_1-3_arc-second_mhw.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  5. Erythropoietin deficiency in acute crescentic glomerulonephritis and in total bilateral renal cortical necrosis

    DEFF Research Database (Denmark)

    Thaysen, J H; Nielsen, O J; Brandi, L

    1991-01-01

    -life and plasma clearance of intravenously injected recombinant human erythropoietin (rhEPO) were determined. The results indicate that the lack of compensatory increase in serum EPO to the anaemic stimulus is not due to increased catabolism, but to decreased synthesis of the renal hormone. Two patients were...

  6. 76 FR 10918 - License Transfer Order for the Cimarron Facility at Crescent, OK

    Science.gov (United States)

    2011-02-28

    ... time of deposit in the mail, or by courier, express mail, or expedited delivery service upon depositing... and C, as well as in the western upland and the western alluvial areas of the site. Final status...

  7. Crescent City, California 1/3 Arc-second NAVD 88 Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) for select U.S. coastal regions. These integrated...

  8. crescent_city_1-3_arc-second_navd_88.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  9. The Infertile Crescent Revisited: A Case (Study for the History of Archaeology

    Directory of Open Access Journals (Sweden)

    Jennifer Bracewell

    2015-05-01

    Full Text Available This paper examines the history of archaeological research concerning the eastern coast of James Bay in northern Quebec. The construction of prehistory in northern Quebec began with the earliest contact of Europeans with Native Canadians and developed from religious explanations to Classical Evolutionary ones to Culture-Historical ones to Neoevolutionary scientific ones. Although the theoretical interpretations changed over time, the content remained surprisingly constant. The challenges of research in the area, and the resulting paucity of data, led to generalizations that telescoped thousands of years and eight million square miles into a single interpretation, based largely on eighteenth- and nineteenth-century assumptions about hunter-gatherer mobility, subsistence and social evolution. This paper traces how these assumptions have affected the archaeology of the twentieth century in James Bay and northern Quebec.

  10. Il crescente indebolimento del sistema finanziario internazionale (The ongoing weakening of the international financial system

    Directory of Open Access Journals (Sweden)

    H.P. GRAY

    2013-10-01

    Full Text Available A hegemon-by-committee, or a group of nations playing the role of a dominant financial power, is necessary for the international financial system to withstand crises arising from drastic shifts of funds among national currencies, accompanied by large movements of exchange rates. These wide fluctuations in exchange rates and subsequent financial transactions can trigger a collapse of prices in dollar-denominated financial assets in US financial markets, thus undermining the global economy. With no single nation apparently capable of playing the hegemon, international cooperation is imperative. An important theme of the paper is that allocative efficiency may not be compatible with adequate financial stability efficiency.JEL: F31, G28

  11. 75 FR 81307 - Notice of Availability of Record of Decision for the Tonopah Solar Energy, LLC, Crescent Dunes...

    Science.gov (United States)

    2010-12-27

    ... generator, water treatment facilities and evaporation ponds, evaporative cooling tower and air cooled condenser (combined to form a hybrid-cooling system), electrical equipment and buildings, heliostat assembly...

  12. Rendimentos crescentes e a distribuição internacional de renda Increasing returns and the international distribution of income

    Directory of Open Access Journals (Sweden)

    Alexandre de Zagottis

    2008-09-01

    Full Text Available The existence of increasing returns in high technology industries assigns a path dependent character to the international division of labor. Rich countries, first entrants in these industries, enjoy permanent advantages that prevent, in a free market environment, the development of such industries in middle-income countries. This dynamics allows the former group of countries to experience a higher growth rate of labor productivity than the latter, and, as a result, increases the gap between the workers' standard of living in these countries. It is up to the States of middle-income countries the task of devising development strategies capable of breaking such pattern and improving the international distribution of income.

  13. Comparison of Sexual Dysfunctions among Employed Women and Housewives Attending’s to Tabriz Counseling Crescent Center Iran

    Directory of Open Access Journals (Sweden)

    Ahmad Esmaili

    2014-12-01

    Full Text Available foundations of healthy family life combined with felicity. Suppress the innate and God-given needs, has undesirable consequences on intimacy and vitality of family members. Therefore, the aim of this study is evaluating and comparing sexual dysfunction of employed women and housewives. Finding the issue that whether there are differences between both groups, and if there is, which of these measures it includes. It is what the study is conducted to achieve. Materials and Methods: The method of this study is descriptive-comparative, that in which 50 person from employed women were select and compared with 50 housewives based on the examination of female sexual function index (FSFI. MANOVA analyses were used for analysis data. Results: The results of the analysis showed that measures of FSFI such as the desire, orgasm and sexual satisfaction have a significant difference with housewife's group. Conclusion: On the basis of findings, it could be said that unlike employed women, housewives suffered from sexual dysfunctions and these disorders can lead to marital dissatisfaction in the life.

  14. 76 FR 47144 - In the Matter of: Jianwei Ding, 51 Bukit Batok Crescent, #0828 Unity Centre, Singapore 658077...

    Science.gov (United States)

    2011-08-04

    ... the China Academy of Space Technology (``CAST''), participated in a scheme whereby he directed... instructions and informed Ding that he ``had to make up the story [when] I call for [a] rate quote.'' On or... kilograms of Toray M40 material to New Bluesky Technology Co. Ltd. in Hong Kong. These exports were destined...

  15. Reticulated Origin of Domesticated Emmer Wheat Supports a Dynamic Model for the Emergence of Agriculture in the Fertile Crescent

    Czech Academy of Sciences Publication Activity Database

    Civáň, P.; Ivaničová, Zuzana; Brown, T.A.

    2013-01-01

    Roč. 8, č. 11 (2013) E-ISSN 1932-6203 Institutional research plan: CEZ:AV0Z50380511 Keywords : RNA MULTIGENE FAMILY * TRITICUM-DICOCCOIDES * PHYLOGENETIC NETWORKS Subject RIV: EF - Botanics Impact factor: 3.534, year: 2013

  16. PERFIL METABÓLICO EM OVINOS ALIMENTADOS COM INCLUSÕES CRESCENTES DA TORTA DO BABAÇU NA DIETA

    Directory of Open Access Journals (Sweden)

    Hemilly Menezes de Sá

    2014-07-01

    Full Text Available The objective was to evaluate the effect of inclusion of babassu pie in sheep feeding on the energy, protein and mineral metabolism, as well as, the effect of collection period on these variables.Twenty males intact sheep were assigned to four treatments, which were inclusion levels babassu pie (zero, 7.5%, 15%, 22.5% in the diet, according to completely randomized design, in split plot, where the parcels were diets and the subplots the collection times (zero, three, six, nine and twelve hours with five replications. There was no interaction between inclusion levels babassu pie and collection time for blood concentrations of total protein, albumin, uric acid, urea, triglycerides, phosphorus and magnesium. No effect of collection time on these variables (P0.05. Having regard to behavior presented by the metabolites analyzed, babassu pie can be used by up to 22.5% in sheep diet, since this level of inclusion does not cause metabolic disorders or reduction in energy, protein and mineral metabolism.

  17. From the Cross (and Crescent) to the Cedar and Back Again: Transnational Religion and Politics Among Lebanese Christians in Senegal

    Science.gov (United States)

    Leichtman, Mara A.

    2013-01-01

    This article examines the changing relationship between religion, secularism, national politics, and identity formation among Lebanese Christians in Senegal. Notre Dame du Liban, the first Lebanese religious institution in West Africa, draws on its Lebanese “national” character to accommodate Lebanese Maronite Catholic and Greek Orthodox Christians in Dakar, remaining an icon of “Lebanese” religion, yet departing from religious sectarianism in Lebanon. As such, transnational religion can vary from national religion, gaining new resonances and reinforcing a wider “secular” ethno-national identity. PMID:24077518

  18. The eastern part of the Fertile Crescent concealed an unexpected route of olive (Olea europaea L.) differentiation.

    Science.gov (United States)

    Mousavi, Soraya; Mariotti, Roberto; Bagnoli, Francesca; Costantini, Lorenzo; Cultrera, Nicolò G M; Arzani, Kazem; Pandolfi, Saverio; Vendramin, Giovanni Giuseppe; Torkzaban, Bahareh; Hosseini-Mazinani, Mehdi; Baldoni, Luciana

    2017-06-01

    Olive is considered a native plant of the eastern side of the Mediterranean basin, from where it should have spread westward along the Mediterranean shores, while little is known about its diffusion in the eastern direction. Genetic diversity levels and population genetic structure of a wide set of olive ecotypes and varieties collected from several provinces of Iran, representing a high percentage of the entire olive resources present in the area, was screened with 49 chloroplast and ten nuclear simple sequence repeat markers, and coupled with archaeo-botanical and historical data on Mediterranean olive varieties. Approximate Bayesian Computation was applied to define the demographic history of olives including Iranian germplasm, and species distribution modelling was performed to understand the impact of the Late Quaternary on olive distribution. The results of the present study demonstrated that: (1) the climatic conditions of the last glacial maximum had an important role on the actual olive distribution, (2) all Iranian olive samples had the same maternal inheritance as Mediterranean cultivars, and (3) the nuclear gene flow from the Mediterranean basin to the Iranian plateau was almost absent, as well as the contribution of subspecies cuspidata to the diversity of Iranian olives. Based on this evidence, a new scenario for the origin and distribution of this important fruit crop has been traced. The evaluation of olive trees growing in the eastern part of the Levant highlighted a new perspective on the spread and distribution of olive, suggesting two routes of olive differentiation, one westward, spreading along the Mediterranean basin, and another moving towards the east and reaching the Iranian plateau before its domestication. © The Author 2017. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  19. Efeitos de concentrações crescentes de lidocaína hiperbárica, administradas no espaço subaracnóideo, sobre a medula espinhal e as meninges: estudo experimental em cães Efectos de concentraciones crecientes de lidocaína hiperbara, administradas en el espacio subaracnoideo, sobre la médula espinal y las meninges: estudio experimental en perros Effects of increasing spinal hyperbaric lidocaine concentrations on spinal cord and meninges: experimental study in dogs

    Directory of Open Access Journals (Sweden)

    Silvânia R.O. Pires

    2006-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Ainda não está bem estabelecida a concentração de lidocaína que é potencialmente capaz de determinar lesão no tecido nervoso. O objetivo desta pesquisa foi estudar os efeitos sobre a medula espinhal e as meninges, de concentrações crescentes de lidocaína administrada por via subaracnóidea, em injeção única através de agulha de Quincke. MÉTODO: Após a aprovação da Comissão de Ética em Experimentação Animal, 40 cães adultos foram anestesiados com fentanil e etomidato e submetidos a punção subaracnóidea com agulha de Quincke 22G 21/2 para introdução de 1 mL, em 10 segundos, de solução glicosada a 7,5% - Grupo 1; lidocaína a 5% em solução glicosada a 7,5% - Grupo 2; lidocaína a 7,5% em solução glicosada a 7,5% - Grupo 3; lidocaína a 10% em solução glicosada a 7,5% - Grupo 4. Após a recuperação da anestesia venosa, foram observados, no período em que os animais estavam em vigência do bloqueio subaracnóideo, a presença de bloqueio motor, o tônus do esfíncter anal (normal ou relaxado e o nível de bloqueio sensitivo nos diferentes dermátomos das regiões cervical, torácica, lombar e sacral. Os animais permaneceram em cativeiro por 72 horas. Foram avaliados o tônus do esfíncter anal, a motricidade das patas posteriores, a sensibilidade dolorosa nas patas anteriores e posteriores e nos dermátomos sacrais, lombares e torácicos. Após serem sacrificados por eletrocussão sob anestesia, foram retiradas porções lombar e sacral da medula espinhal e das meninges para exame histológico por microscopia óptica. RESULTADOS: Nenhum animal dos Grupos 1 e 2 apresentou lesões clínicas ou histológicas. Três animais do Grupo 3 apresentaram alterações motoras nas patas posteriores e relaxamento do esfíncter anal. Nestes, foram observados focos de necrose na região posterior (dois cães e necrose em faixa em toda a superfície medular (um cão. Em um outro animal deste grupo, no

  20. Red Crescent and its effect on the geography security on eastern borders (comparative study of social abnormalities during 1383-89

    Directory of Open Access Journals (Sweden)

    Farokh allah Shahbahrami

    2011-02-01

    Full Text Available Objective: drugs have some multidimensional effects on people and their lives. People who live in eastern provinces are at the risk of getting addicted and abnormal. Afghanistan is and has been the main problem for Iran. Method: this research has been done by library method and for this many books and articles have been read. The determined time was about 6 years. Findings: drugs have direct effects on life of people. Border cities are under the unkind effects of drugs and its relevant things. Conclusion: authorities must pay too much attention to drugs and eastern provinces

  1. Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis

    NARCIS (Netherlands)

    Heeringa, P; van Goor, H; Moshage, H; Klok, PA; Huitema, MG; de Jager, A; Schep, AJ; Kallenberg, CGM

    Nitric oxide radicals are recognized as important mediators in various physiological and pathophysiological processes. During inflammation, increased amounts of nitric oxide (NO) are produced, but it is unclear whether NO radicals are either protective or harmful. To obtain more insight into the

  2. BIOMETRIA TESTICULAR DE CORDEIROS EM DIFERENTES IDADES E ALIMENTADOS COM NÍVEIS CRESCENTES DE FIBRA EM DETERGENTE NEUTRO ORIUNDA DA FORRAGEM

    Directory of Open Access Journals (Sweden)

    Roberta Moura Assis

    2014-12-01

    Full Text Available The experiment was conducted at the Federal University of Lavras. We used 64 lambs, which, after birth, were divided into four treatments: Diet A - 8.67; Diet B - 17.34, Diet C - 26.01 and Diet D - 34.68% neutral detergent fiber from forage (NDFf in the diet. At three days of age, lambs were separated from their mothers and began receiving sheep milk replacer until weaning at 55 days. The experimental diets were isonitrogenous, formulated to meet the nutritional requirements of growing lambs, except for energy. Four digestibility diet essays were conducted for determining of metabolizable energy (ME at different ages (43, 83, 123 and 173 days of life. The biometric variables analyzed were weight, testis weight, scrotal circumference and volume. The experimental design was in randomized blocks (DBC, in a 4 x 4 factorial arrangement (four levels of dietary NDFf and four slaughter ages, with 4 replicates per treatment. The estimation of scrotal circumference by weight proved to be more efficient than in function of age. The prediction of the size and weight of the testes through scrotal circumference was more efficient than by the age and body weight. Animals fed diets with less fiber from forage, that is, with greater amount of energy, showed better results of testis biometry compared to the animals fed smaller amounts of energy.

  3. The crescent and Islam: healing, nursing and the spiritual dimension. Some considerations towards an understanding of the Islamic perspectives on caring.

    Science.gov (United States)

    Rassool, G H

    2000-12-01

    Caring from Islamic perspectives is not well versed in Eurocentric nursing literature. There is widespread misunderstanding of the concept and practice of Islam within the context of health care and nursing practice. The areas of contention, in the context of health care systems, are whether the western paradigm to nursing care and management are applicable to Muslims and non-Muslims in both Islamic and non-Islamic countries. What is lacking in some of the conceptual frameworks and models of care is not only the fundamental spiritual dimension of care, but also the significance of spiritual development of the individual towards healing. The focus of this paper is to provide an awareness of Islamic health practices, health behaviours, code of ethics and the framework of Islamic perspectives of caring and spirituality. A brief overview of the Muslim world, the historical development in caring and health and the pillars of the Islamic faith provide the context of the paper. The development of a model of care based on the Islamic perspective is suggested.

  4. Efeito de déficit hídrico transiente e doses crescentes de boro sobre a fertilidade de gemas de videira cv. Itália

    Directory of Open Access Journals (Sweden)

    Jorbas Sampaio de Melo

    2011-06-01

    Full Text Available O objetivo deste trabalho foi verificar o efeito de diferentes tensões de água no solo e diferentes concentrações de boro, na fertilidade de gemas de videira cv. Itália, manejada sob o sistema de poda mista. O experimento foi conduzido em pomar comercial, no município de Petrolina-PE. O delineamento experimental utilizado foi o de blocos ao acaso, em esquema fatorial 3x3: três tensões indicativas para a recarga hídrica por irrigação (-30 kPa, -50 kPa e -70 kPa e três concentrações de boro (3%, 6% e 9%, com três repetições e duas plantas por parcela. A testemunha não recebeu aplicações com boro e o solo foi mantido com umidade na capacidade de campo (-10 kPa. As variáveis analisadas foram fertilidade de gemas, índice relativo de clorofila (IRC e área foliar. Os dados foram interpretados por meio de análise de variância e regressão, e os modelos escolhidos com base na significância do coeficiente de regressão (R² > 0,70. Verificou-se que a fertilidade de gemas mostrou efeito linear negativo em função do aumento da tensão de água no solo, diminuindo de 31,88% (-30 kPa, para 23,66% (-70 kPa. Contudo, a fertilidade de gemas nas videiras submetidas a uma restrição hídrica de -30 kPa foi superior à tensão de -10 kPa; o boro a 3% propiciou a maior taxa de fertilidade de gemas em comparação aos demais tratamentos com boro; a restrição hídrica no solo a -30 kPa ocasionou economia no volume de água aplicada da ordem de 35,4% em comparação ao manejo com -10 kPa; o índice relativo de clorofila aumentou linearmente com o acréscimo das tensões de água no solo e houve maior expansão da área foliar em plantas submetidas ao manejo da irrigação na capacidade de campo.

  5. EFEITOS DA SUPLEMENTAÇÃO DE BICARBONATO DE SÓDIO EM UM TESTE ERGOMÉTRICO DE ESFORÇO CRESCENTE EM HOMENS RECREACIONALMENTE ATIVOS

    Directory of Open Access Journals (Sweden)

    Everton Marcio Derisso

    2014-02-01

    Full Text Available The supplementation of sodium bicarbonate (NaHCO3 is being used as a way to induce blood alkalosis and increase the buffering chemical capacity. The literature shows a need for studies that use supplemental NaHCO3 at high intensities lasting more than 5 minutes. This study compares the effect of supplementation of NaHCO3 in speed corresponding to maximum working speed (vMAX and the respiratory compensation point (vRCP during an incremental treadmill test. We evaluate six recreationally active males (22.00 ± 2.00 years, 81.80 ± 9.90 kg, 1.81 ± 0.06 m and BMI 25 ± 2 kg/m2 and previously trained. The volunteers presented to the laboratory on two different days. They ingested 0.1 g/kg body weight of NaHCO3 (Group B or placebo with calcium carbonate (CaCO3 (Group P and performed an incremental test on a treadmill with 1km/h increments every 2 minutes until volitional exhaustion maximum. There was no significant difference in the velocities corresponding to vPCR and vMAX with supplementation of NaHCO3 and in any respiratory parameter. The ingestion of NaHCO3 at a concentration of 0.1 g/kg body weight does not improve performance in an incremental test on a treadmill.

  6. Produtividade e valor nutritivo do capim-elefante cv. Napier sob doses crescentes de nitrogênio e potássio

    Directory of Open Access Journals (Sweden)

    Andrade Alex Carvalho

    2000-01-01

    Full Text Available Avaliaram-se os efeitos das adubações nitrogenada e potássica sobre o capim-elefante "Napier". Quatorze combinações entre N e K, de um fatorial incompleto de N e K, avaliados em sete doses de N (20, 50, 100, 200, 300, 350 e 380 kg/ha de N e sete de K (16, 40, 80, 160, 240, 280 e 304 kg/ha de K, foram obtidas de acordo com a matriz Box Berard aumentada 3, com acréscimo de um ponto. Os tratamentos foram distribuídos em blocos ao acaso com três repetições. A produtividade foi aumentada pelas adubações nitrogenada e potássica em 86%. A relação lâmina/colmo e o teor de Mg2+ diminuíram com a adubação potássica. Os teores de P e Ca2+ diminuíram com a adubação nitrogenada, enquanto o teor de proteína bruta aumentou de maneira quadrática pelas adubações nitrogenada e potássica. O teor de K aumentou com a adubação potássica e diminuiu com a nitrogenada. O nível crítico de potássio na planta foi 1,85 dag/kg na matéria seca.

  7. CONSERVAÇÃO DE INFLORESCÊNCIAS DE HELICÔNIAS PREVIAMENTE ADUBADAS COM DOSES CRESCENTES DE NITROGÊNIO E POTÁSSIO

    Directory of Open Access Journals (Sweden)

    GENILDA CANUTO AMARAL

    2015-01-01

    Full Text Available The post-harvest of floral stems is one of the main features observed in the production of flowers for cutting, becoming a prerequisite for product quality and successful marketing. In this sense, the objective was to evaluate the conservation of heliconias inflorescences with or without renewal of the water maintenance, previously fertilized with increasing doses of nitrogen and potassium. Inflorescences of Heliconia psittacorum x H. spathocircinata cultivar Golden Torch were used and grown in open conditions in the Floriculture area at UFPI, city of Bom Jesus, Piauí State under increasing doses of fertilization with N and K. The stems were harvested in the morning, standardized and placed in containers with 500 mL of water. The design was a randomized block in factorial 4 x 4 x 2, corresponding to: i N doses (0, 120, 180, and 240 g N hole-1 , ii K doses (0, 120, 180, and 240 g K2O hole-1 , and iii renewing the water maintenance in vase (with and without renewal with three replicates of three stems each. Some evaluations were observed during the Study, such as: the water uptake by the flower stems; loss of fresh weight of the flower stems, dry weight of the flower stems and post-harvest longevity. The dose of 180 g hole-1 both as N and K provided the longevity of the flower stems with quality maintenance. The absorption of water by the flower stems and its dry mass after harvesting are influenced by previous fertilizer N and K. The renewal of the water maintenance also positively influence the longevity of flower stems and its a management indicated to maintain quality post-harvest.

  8. Bioethanol: the new source for growing CO{sub 2} demand?; Bioetanol: a nova fonte para a demanda crescente por CO{sub 2}?

    Energy Technology Data Exchange (ETDEWEB)

    Martynowicz, Emile T.M.J. [Norit Haffmans, Venlo (Netherlands); Mekss, Varidots Dainis Thorvalds [Norit do Brasil Ltda., Sao Paulo, SP (Brazil)

    2009-11-01

    In recent years, while customers demand a more sustainable greener CO{sub 2} source, the worldwide demand for food-grade CO{sub 2} is steadily increasing. In Brazil, a large bio-ethanol producer, the CO{sub 2} from the bio-ethanol production is an alternative. The research focused on the activated carbon filter in a CO{sub 2} recovery plant in respect to its removal efficiency for sulfurous compounds, such as H{sub 2}S and COS. Five different types of activated carbons were investigated both in pilot scale tests as well as in full scale tests. The different adsorption behavior in respect to COS for the activated carbon was attributed to the variance in mineral trace element composition of the activated carbon. Finally, an activated carbon was selected, that could remove H{sub 2}S, DMS and COS concentrations in the low ppm range to levels of less than 20 ppbw, in even more than 50 thermal adsorption/desorption cycles. This activated carbon was tested in a full scale plant and proved to be very suitable for the process conditions encountered in a bioethanol plant. (author)

  9. Gluteoplastia de aumento: a importância do ensino na formação atual do residente frente à demanda crescente

    OpenAIRE

    Lima, Diogo Almeida; Minakami, Daniel Akira; Pereira, Lucas Chagas; Grando, Maieve Corralo; Cruz, Ricardo Souza; Braga, André Ramalho; Almeida Neto, Enéas Cardoso de; Guimarães, Rodrigo Araújo; Almeida, Ronaldo Carrara de; Souza Neto, Acrysio Peixoto de; Haesbaert, Cristiam Machado; Grave, Márcio; Zambenedetti, Ricardo Morgental; Cardoso, Marcelo Moreira; Resende, José Humberto Cardoso

    2011-01-01

    INTRODUÇÃO: Frente ao aumento na demanda por gluteoplastia de aumento com implantes nos últimos anos, é importante que haja profissionais treinados e capacitados para realizar tal procedimento e suas associações com lipoaspiração/lipoenxertia, com o intuito final de melhorar o contorno do quadril. MÉTODO: Ao ver na residência médica o local de ensino apropriado para tal prática, elaboramos o estudo de 20 casos tratados por médicos residentes em treinamento sob supervisão, a fim de observar a ...

  10. Países da Unasur: exibição e novas plataformas de cinema para uma produção crescente

    Directory of Open Access Journals (Sweden)

    Diego Rossi

    2016-11-01

    Full Text Available El desarrollo de una industria audiovisual nacional con mercado interno y proyección iberoamericana en múltiples pantallas de exhibición, para los diez principales países de Unasur, enfrenta limitaciones y nuevas posibilidades en un entorno digitalizado y global. Se realiza un análisis de los resultados del quinquenio 2010-2014 en materia de estrenos fílmicos, de asistencia a salas, y la relación entre materiales exhibidos según país de origen de su producción. Asimismo, se aborda la disponibilidad de diversas pantallas, más allá de la sala cinematográfica, las políticas ante el Virtual Print Fee y las cuotas de pantalla, en una irresuelta integración de mecanismos de cooperación y regulación conjunta que incidan efectivamente en la diversidad ofrecida y los hábitos de consumo.

  11. ABC crescent. Energy concept with active storage system for a Hamburg office building; ABC - Bogen. Energiekonzept mit Aktivspeichersystem fuer ein Buerohaus in Hamburg

    Energy Technology Data Exchange (ETDEWEB)

    Stoll, J. [HL-Technik AG, Muenchen (Germany). Bereich Future Building Designs, Thermische Bauphysik-Bauklimatik

    1999-07-01

    This new multifunctional building will house a shopping mall and offices. Natural ventilation is favoured as far as possible. Technical facilities were minimised in order to save resources and reduce the operating cost. The architectural design was to be as functional as possible. [German] Mit dem ABC-Bogen in Hamburg entsteht in unmittelbarer Naehe zum Gaensemarkt ein multifunktionales Gebaeude mit Passagen, Laeden und Bueros - ein neuer Akzent in der Hamburger Innenstadt. Das grosszuegig verglaste Gebaeude sollte nach den Zielen der Hamburger Architekten BRT - Bothe, Richter, Teherani und der Projektentwicklung (SF-Bau Projektentwicklung GmbH, NL Hamburg) soweit wie moeglich natuerlich gelueftet werden. Die gebaeudetechnische Ausruestung der Bueros war zur Ressourcenschonung und Begrenzung der Betriebskosten auf ein Mindestmass zu beschraenken. Bei der Fassadengestaltung sollten funktionelle Aspekte absoluten Vorrang haben. (orig.)

  12. An integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenya.

    Science.gov (United States)

    Fèvre, Eric M; de Glanville, William A; Thomas, Lian F; Cook, Elizabeth A J; Kariuki, Samuel; Wamae, Claire N

    2017-06-30

    The neglected zoonotic diseases (NZD) are an understudied group that are a major cause of illness throughout the developing world. In general, little is known about the prevalence and burden of NZDs in affected communities, particularly in relation to other infectious diseases with which they are often co-endemic. We describe the design and descriptive epidemiological outputs from an integrated study of human and animal zoonotic and non-zoonotic disease in a rural farming community in western Kenya. This cross-sectional survey involved 2113 people, their cattle (n = 983) and pigs (n = 91). People and animals were tested for infection or exposure to a wide range of zoonotic and non-zoonotic pathogens. Prevalence estimates, with adjustment for the complex study design, were derived. Evidence for spatial clustering in exposure or infection was identified using the spatial scan statistic. There was a high prevalence of human parasitism in the community, particularly with hookworm (Ancylostoma duodenale or Necator americanus) (36.3% (95% CI 32.8-39.9)), Entamoeba histolytica/dispar (30.1% (95% CI 27.5-32.8)), and Plasmodium falciparum (29.4% (95% CI 26.8-32.0)). Human infection with Taenia spp. was also prevalent (19.7% (95% CI 16.7-22.7)), while exposure to other zoonotic pathogens was comparatively rarer (Brucella spp., 0.6% (95% CI 0.2-0.9); Coxiella burnetii, 2.2% (95% CI 1.5-2.9); Rift Valley fever, 0.5% (95% CI 0.2-0.8)). A low prevalence of exposure to Brucella spp. was observed in cattle (0.26% (95% CI 0-0.56). This was higher for Rift Valley fever virus (1.4% (95% CI 0.5-2.22)) and C. burnetii (10.0% (95% CI 7.7-12.2)). The prevalence of Taenia spp. cysticercosis was 53.5% (95% CI 48.7-58.3) in cattle and 17.2% (95% CI 9.1-25.3) in pigs. Mycobacterium bovis infection was found in 2.2% of cattle (95% CI 1.3-3.2), while the prevalence of infection with Mycobacterium spp. was 8.2% (95% CI 6.8-9.6) in people. Zoonotic infections in people and animals occur in the context of a wide range of co-endemic pathogens in a rural community in western Kenya. The wide diversity of pathogens under study provides a unique opportunity to explore the distribution and determinants of infection in a multi-pathogen, multi-host system.

  13. Wegener’s granulomatosis mimicking inflammatory bowel disease and presenting with chronic enteritis

    Directory of Open Access Journals (Sweden)

    Shahedi K

    2013-10-01

    Full Text Available Kamyar Shahedi,1,2 Ramy Magdy Hanna,1,2 Oleg Melamed,1,2 James Wilson2,31Department of Medicine Olive-View UCLA Medical Center, Sylmar, CA, 2David Geffen School of Medicine at UCLA, Los Angeles, CA, 3UCLA Medical Center-UCLA Stone Center, Los Angeles, CA, USAAbstract: Wegener’s granulomatosis, also known as anti-neutrophil cytoplasmic antibody (ANCA-associated vasculitis, is a small vessel vasculitis with primarily pulmonary, renal, and sinus disease manifestations. The prevalence of Wegener’s granulomatosis is three cases per 100,000 patients. Cardiovascular, neurologic, cutaneous, and joint manifestations have been reported in many case reports and case series. Gastrointestinal manifestations are less noted in Wegener’s granulomatosis, although they have been previously reported in the form of intestinal perforation and intestinal ischemia. Additionally, there are characteristic findings of vasculitis that are noted with active Wegener’s granulomatosis of the small bowel. We report a case of an elderly patient who presented with weight loss, diarrhea, and hematochezia. His symptoms were chronic and had lasted for more than 1 year before diagnosis. Inflammatory bowel disease or chronic enteritis due to Salmonella arizonae because of reptile exposure originally were suspected as etiologies of his presentation. The findings of proteinuria, renal failure, and pauci-immune glomerulonephritis on renal biopsy, in conjunction with an elevated c-ANCA titer, confirmed the diagnosis of Wegener’s granulomatosis with associated intestinal vasculitis. This case demonstrates an atypical presentation of chronic duodenitis and jejunitis secondary to Wegener’s granulomatosis, which mimicked inflammatory bowel disease.Keywords: ANCA-associated vasculitis, Wegener’s syndrome, pauci-immune glomerulonephritis, Salmonella arizonae, inflammatory bowel disease

  14. Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis

    Science.gov (United States)

    Jarrot, Pierre-Andre; Chiche, Laurent; Hervier, Baptiste; Daniel, Laurent; Vuiblet, Vincent; Bardin, Nathalie; Bertin, Daniel; Terrier, Benjamin; Amoura, Zahir; Andrés, Emmanuel; Rondeau, Eric; Hamidou, Mohamed; Pennaforte, Jean-Loup; Halfon, Philippe; Daugas, Eric; Dussol, Bertrand; Puéchal, Xavier; Kaplanski, Gilles; Jourde-Chiche, Noemie

    2016-01-01

    Abstract The aim of the study was to report the clinical, biological, and pathological characteristics of patients with glomerulonephritis (GN) secondary to systemic lupus erythematosus (SLE)/antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) overlap syndrome. A nationwide survey was conducted to identify cases of SLE/AAV overlap syndrome. Data were collected from SLE and AAV French research groups. Inclusion criteria were diagnosis of both SLE and AAV according to international classification criteria and biopsy-proven GN between 1995 and 2014. Additional cases were identified through a systematic literature review. A cohort of consecutive biopsy-proven GN was used to study the prevalence of overlapping antibodies and/or overlap syndrome. The national survey identified 8 cases of SLE/AAV overlap syndrome. All patients were female; median age was 40 years. AAV occurred before SLE (n = 3), after (n = 3), or concomitantly (n = 2). Six patients had rapidly progressive GN and 3/8 had alveolar hemorrhage. All patients had antinuclear antibodies (ANA); 7/8 had p-ANCA antimyeloperoxidase (MPO) antibodies. Renal biopsies showed lupus nephritis (LN) or pauci-immune GN. Remission was obtained in 4/8 patients. A literature review identified 31 additional cases with a similarly severe presentation. In the GN cohort, ANCA positivity was found in 30% of LN, ANA positivity in 52% of pauci-immune GN, with no correlation with pathological findings. The estimated prevalence for SLE/AAV overlap syndrome was 2/101 (2%). In patients with GN, SLE/AAV overlap syndrome may occur but with a low prevalence. Most patients have an aggressive renal presentation, with usually both ANA and anti-MPO antibodies. Further studies are needed to assess shared pathogenesis and therapeutic options. PMID:27258503

  15. Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Thiel, Jens; Hässler, Fabian; Salzer, Ulrich; Voll, Reinhard E; Venhoff, Nils

    2013-09-24

    Eosinophilic granulomatosis with polyangiitis (EGPA) is part of antineutrophil cytoplasmic antibodies (ANCAs)-associated vasculitides. In EGPA small-vessel vasculitis is associated with eosinophilia and asthma. About 40% of EGPA patients are ANCA-positive, suggesting a role for B cells in the pathogenesis of EGPA. B cell-depleting therapy with rituximab (RTX) can be effective in ANCA-positive EGPA, but very few patients have been published to date. The role of RTX in the treatment of ANCA-negative EGPA is unclear. We report a single-center cohort of patients with eosinophilic granulomatosis with polyangiitis. Of these patients, nine (six ANCA-positive, three ANCA-negative) had been treated with RTX for relapsing or refractory disease on standard immunosuppressive treatment. In a retrospective analysis, data on treatment response, frequency of relapses, adverse events, and peripheral B-cell reconstitution were evaluated. Furthermore, serum immunoglobulin concentrations, ANCA status, and peripheral B cell subpopulations were assessed after RTX treatment. All patients had high disease activity before RTX treatment. At presentation 3 months after RTX therapy, all ANCA-positive and ANCA-negative patients had responded to RTX, with one patient being in complete remission, and eight patients being in partial remission. After a mean follow-up of 9 months, C-reactive protein concentrations had normalized, eosinophils had significantly decreased, and prednisone had been tapered in all patients. In all patients, RTX therapy was combined with a standard immunosuppressive therapy. Within the 9-month observation period, no relapse was recorded. Three patients were preemptively retreated with RTX, and during the median follow-up time of 3 years, no relapse occurred in these patients. During the follow-up of 13 patient-years, five minor but no major infections were recorded. In our analysis on nine patients with EGPA resistant to standard therapy, rituximab proved to be an

  16. Desempenho de perus de corte alimentados com níveis crescentes de aflatoxinas, com ou sem adição de adsorvente Turkey performance fed with increasing aflatoxins levels, with or without adsorvent inclusion

    Directory of Open Access Journals (Sweden)

    Janio Morais Santurio

    1998-03-01

    Full Text Available Este trabalho foi realizado durante o verão de 1995/96 com o objetivo de determinar o nível de aflatoxinas (AFL capaz de causar prejuízos no desempenho de perus de corte criados sob condições ambientais de baixo desafio, bem como avaliar a eficácia da adição de bentonita sódica natural (BSN como um adsorvente. Foram utilizados 1008 perus de corte, alojados em 84 boxes seguindo um delineamento experimental de blocos casualizados com 14 tratamentos distribuídos em um arranjo fatorial 7x2, sendo 7 níveis de adição de AFL, (0, 10, 50, 100, 500, 1000 e 2000ppb e 2 níveis de adição de BSN (0 e 0,5%. Aos 21 dias de idade, as aves alimentadas com as dietas sem adição de BSN mostraram uma redução significativa (PThis experiment was carried out in the 1995/96 summer to determine the aflatoxin (AFL levels ability to decrease turkey performance raised under excellent environmental conditions and also to avaluate a natural sodium bentonite (NSB efficiency as an adsorbent. One thousand and eight poults were housed in 84 floor pens following a randomized complete block design with 14 treatments arranged in a 7x2 factorial, with 7 AFL levels (0, 10, 50, 100, 500, 1000 and 2000ppb and 2 NSB levels (0 and 0.5%. At 21 days of age the birds fed without NSB showed body weight gain (BWG and feed intake (FI reduction (P<0.05 from 500ppb or more of AFL, whereas the birds fed with NSB showed BWG and FI reduction (P<0.05 only from 1000ppb or more of AFL. These same results were observed at 40 days of age, but at 70 days, the BWG and FI reduction was statistically significant (P<0.05 from 500ppb or more of AFL, with or without NSB inclusion. In general, birds fed with NSB had about 15 to 20% less BWG and FI reduction than birds fed without NSB. The feed conversion (FC was less affected by AFL levels, although it worsened with increasing AFL levels. AFL have greatly affected the mortality rate. At 21 days of age the birds fed with 1000 and 2000pbb of AFL have already presented 15.3 and 72.2% of mortality, respectively and until 40 days all birds fed with 2000ppb of AFL died. However there was a benefic effect of NSB inclusion. Based on theses results can be concluded that AFL are highly deleterious for turkey and that NSB can partialy protect the birds from AFL negativo effects.

  17. Effects of increasing use of trifluralin and glyphosate on the microbial activity of a lea soil; Efeito de doses crescentes dos herbicidas trifluralina e glifosato sobre a atividade microbiana de um solo de varzea

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Edna Santos de; Monteiro, Regina Teresa Rosim [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil); Peixoto, Maria de Fatima da Silva Pinto [Sao Paulo Univ., Piracicaba, SP (Brazil). Escola Superior de Agricultura Luiz de Queiroz. Dept. de Quimica. E-mail: mfsppeix@carpa.ciagri.usp.br; Fay, Elizabeth Francisconi [Empresa Brasileira de Pesquisa Agropecuaria, Jaguariuna, SP (Brazil). Centro Nacional de Pesquisa de Defesa da Agricultura. E-mail: bethfay@cnpma.embrapa.com.br

    1997-07-01

    This work considers the importance of the glyphosate and trifluralin, which are the most used herbicides by the brazilian plantations, applying approximately fifteen and nine millions of liters by crop, respectively, for the evaluation of the increasing use of these herbicides effects on the microbial activity of a lea soil which are used for beans cultivation.

  18. Câncer de mama: mortalidade crescente na Região Sul do Brasil entre 1980 e 2002 Increase in breast cancer mortality in Southern Brazil from 1980 to 2002

    Directory of Open Access Journals (Sweden)

    Andrea T. Cadaval Gonçalves

    2007-08-01

    Full Text Available O câncer de mama é apontado como o tipo de câncer mais prevalente no mundo. No Brasil, as taxas de mortalidade por câncer de mama continuam elevadas, observando-se diferenças inter-regionais. Foi realizado um estudo ecológico de série temporal (1980-2002 na Região Sul, com dados anuais do Departamento de Informação e Informática do SUS (DATASUS, para avaliar o comportamento do coeficiente de mortalidade por câncer de mama, padronizado por idade. Utilizou-se regressão linear simples e múltipla para estimar as taxas de mortalidade e as diferenças entre os três Estados. O Rio Grande do Sul parte de um patamar mais elevado e apresenta maior taxa média de mortalidade (14,45, sendo significativamente diferente (p Breast cancer is the most prevalent form of cancer in the world. Breast cancer mortality rates are high in Brazil and show striking variations between geographic regions. A time-trend ecological study was performed in Southern Brazil from 1980 to 2002. Data were collected from the Mortality Information System (Ministry of Health to assess age-standardized mortality rates. Linear regression for mortality time-trend analysis and multiple regression for mortality differences among three States were calculated. The highest mean mortality rate (14.45 was observed in Rio Grande do Sul, significantly greater (p < 0.001 than in Santa Catarina (8.93 and Paraná (9.95. An annual increase of 0.47 in the mortality rate was observed in the three States of Southern Brazil. According to these results, the South of Brazil and especially the State of Rio Grande do Sul showed a significant upward trend in breast cancer mortality. Continued efforts are needed to help explain these numbers and reverse the present situation.

  19. Smart Gold Nanobowls (Nano-Crescent Moon) with Sub-10 nm Circular Edge for Local Electromagnetic Field Enhancement Effect, Spatial, and NIR Temporal/Thermal Modulations for Molecular and Cellular Dynamic Imaging

    Science.gov (United States)

    2006-01-31

    nanoring [10], the Au nanocrescent has a higher local field enhancement factor in the near infrared wavelength region due to the simultaneous...incorporation of SERS hot spots including sharp nanotip and nanoring geometries and thus the strong hybrid resonance modes from nanocavity resonance mode and tip...Raman, "A change of wave-length in light scattering," Nature 121, 619-619 (1928). 22. Y. Lu, G. L. Liu, and L. P. Lee, "High-density silver nanoparticle

  20. Sevoflurano e desflurano sobre o ritmo cardíaco de cães tratados com infusão contínua de doses crescentes de adrenalina

    Directory of Open Access Journals (Sweden)

    Nunes Newton

    2004-01-01

    Full Text Available Os anestésicos inalatórios sensibilizam o miocárdio ou seu sistema de condução à ação das catecolaminas endógenas e/ou exógenas, predispondo o animal às arritmias cardíacas. Dentre os anestésicos voláteis, o sevoflurano e o desflurano são fármacos relativamente recentes e, embora sejam dotados de características relacionadas a não sensibilização do miocárdio às catecolaminas, desconhecem-se estudos que comparem suas eventuais propriedades antiarritmogênicas. Com o objetivo de estudar, comparativamente, o comportamento do ritmo cardíaco e observar eventuais bloqueios atrioventriculares em cães anestesiados pelo sevoflurano e desflurano e submetidos à infusão contínua de adrenalina, foram utilizados 20 animais adultos, os quais foram separados em dois grupos de igual número (G1 e G2. Aos cães do G1, foi administrado propofol, na dose média de 10mmg.kg-1; em seguida os animais receberam sevoflurano, a 1,5CAM. Decorridos 30 minutos do início da administração do anestésico volátil, iniciou-se a infusão de adrenalina na dose de 1mmg.kg-1.min-1. A cada 10 minutos, a dose da catecolamina foi acrescida em uma unidade, cessando-se a administração em 6mmg.kg-1.min-1. Para o G2, empregou-se a mesma metodologia, substituindo-se o sevoflurano pelo desflurano, administrado a 1,5CAM. A cada dose de adrenalina, foi feita contagem de batimentos ventriculares ectópicos, bem como a observação de bloqueios atrioventriculares. Os achados foram tratados pelos métodos estatísticos de Análise de Perfil e Kruskall-Wallis. Os resultados permitiram concluir que o desflurano minimiza de maneira mais eficiente a arritmia induzida pela adrenalina, além de reduzir a incidência de bloqueios atrioventriculares.

  1. Purpura, petechiae, and bullae as first signs of juvenile granulomatosis with polyangiitis.

    Science.gov (United States)

    Rawn, Saara; Miettunen, Paivi; Brown, Holly A; Schmeling, Heinrike

    2014-12-01

    We present a case of a 14-year-old girl who had a severe form of granulomatosis with polyangiitis (GPA) with extensive dermatological involvement, whose initial presentation was nonspecific leading to diagnostic confusion and initial consideration of infectious and other vasculitis causes. The patient presented with fever, congestion, malaise, and sinus pain. She was diagnosed with bacterial sinusitis and treated with antibiotics. Within weeks, she developed abdominal pain, hematuria, migratory arthritis, and palpable purpura and was diagnosed with Henoch-Schonlein purpura. She went on to develop hemoptysis and progression of the rash into erosive bullae. Investigations revealed that she was ANCA positive and had pauci-immune glomerulonephritis. Given her upper airway, pulmonary and renal involvement, and antineutrophil cytoplasmic antibodies positivity, a definitive diagnosis of a severe form of GPA was made. GPA is a chronic relapsing, life threatening vasculitis that predominantly affects small vessels. Our case demonstrates that GPA can present initially with nonspecific symptoms, including extensive dermatological involvement, leading to diagnostic confusion, and delays in treatment. In the case of a severe peripheral rash in the juvenile population and/or resistant upper airway symptoms, it is vital to consider a diagnosis of GPA to avoid serious organ or life threatening consequences.

  2. Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

    Directory of Open Access Journals (Sweden)

    Mark A Little

    Full Text Available Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3 antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis. Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on murine neutrophils, and by different Fc-receptor affinities for IgG across species. Therefore, we tested whether human anti-PR3 antibodies can induce acute vasculitis in mice with a human immune system. Chimeric mice were generated by injecting human haematopoietic stem cells into irradiated NOD-scid-IL2Rγ⁻/⁻ mice. Matched chimera mice were treated with human IgG from patients with: anti-PR3 positive renal and lung vasculitis; patients with non-vasculitic renal disease; or healthy controls. Six-days later, 39% of anti-PR3 treated mice had haematuria, compared with none of controls. There was punctate bleeding on the surface of lungs of anti-PR3 treated animals, with histological evidence of vasculitis and haemorrhage. Anti-PR3 treated mice had mild pauci-immune proliferative glomerulonephritis, with infiltration of human and mouse leukocytes. In 3 mice (17% more severe glomerular injury was present. There were no glomerular changes in controls. Human IgG from patients with anti-PR3 autoantibodies is therefore pathogenic. This model of anti-PR3 antibody-mediated vasculitis may be useful in dissecting mechanisms of microvascular injury.

  3. Paquimeningitis hipertrófica, glomerulonefritis y vasculitis de pequeños vasos asociada a ANCA Hypertrophic pachymeningitis, glomerulonephritis and P-ANCA associated small vessel vasculitis

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    Octavio Mazzocchi

    2007-04-01

    Full Text Available La paquimeningitis hipertrófica es una enfermedad poco frecuente caracterizada por engrosamiento de la duramadre. Presentamos una paciente con esta enfermedad que se manifestó con cefalea crónica y en la que concomitantemente se evidenció una glomerulonefritis necrotizante extracapilar pauciinmune asociada a anticuerpos anticitoplasma de neutrófilos de patrón perinuclear (ANCA-P. El diagnóstico se estableció por resonancia nuclear magnética. Recibió tratamiento inmunosupresor con prednisona y ciclofosfamida con evolución favorable.Hypertrophic pachymeningitis is a very unusual disease, the main characteristic of which is thickening of the dura mater. We describe a patient who started this illness showing chronic headache and pauci-immune necrotizing extracapillary perinuclear antineutrophil cytoplasmic antibody (P-ANCA associated glomerulonephritis. The diagnosis was made by brain magnetic resonance image. She received immunosuppressant therapy with prednisonel and cyclophosphamide with clinical improvement.

  4. Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study

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    Sanjeevan Sriskandarajah

    2017-01-01

    Full Text Available Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary cyclophosphamide-sparing protocols. Methods. Patients from the Norwegian Kidney Biopsy Registry between 1988 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody (ANCA serology were included. Standardised incidence ratios (SIRs were calculated to compare the study cohort with the general population. Results. The study cohort included 419 patients. During 3010 person-years, cancer developed in 41 patients (9.79%; the expected number of cancer cases was 37.5 (8.95%. The cohort had SIRs as follows: 1.09, all cancer types (95% CI, 0.81 to 1.49; 0.96, all types except nonmelanoma skin cancer (95% CI, 0.69 to 1.34; 3.40, nonmelanoma skin cancer (95% CI, 1.62 to 7.14; 3.52, hematologic cancer (95% CI, 1.32 to 9.37; 2.12, posttransplant cancer (95% CI, 1.01 to 4.44; and 1.53, during the 1–5-year follow-up after diagnosis (95% CI, 1.01 to 2.32. Conclusions. Cancer risk did not increase significantly in this cohort with ANCA-associated glomerulonephritis. However, increased risk of nonmelanoma skin cancer, posttransplant cancer, and hematologic cancer indicates an association between immunosuppression and malignancy.

  5. Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

    LENUS (Irish Health Repository)

    Little, Mark A

    2012-01-01

    Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener\\'s granulomatosis). Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on murine neutrophils, and by different Fc-receptor affinities for IgG across species. Therefore, we tested whether human anti-PR3 antibodies can induce acute vasculitis in mice with a human immune system. Chimeric mice were generated by injecting human haematopoietic stem cells into irradiated NOD-scid-IL2Rγ⁻\\/⁻ mice. Matched chimera mice were treated with human IgG from patients with: anti-PR3 positive renal and lung vasculitis; patients with non-vasculitic renal disease; or healthy controls. Six-days later, 39% of anti-PR3 treated mice had haematuria, compared with none of controls. There was punctate bleeding on the surface of lungs of anti-PR3 treated animals, with histological evidence of vasculitis and haemorrhage. Anti-PR3 treated mice had mild pauci-immune proliferative glomerulonephritis, with infiltration of human and mouse leukocytes. In 3 mice (17%) more severe glomerular injury was present. There were no glomerular changes in controls. Human IgG from patients with anti-PR3 autoantibodies is therefore pathogenic. This model of anti-PR3 antibody-mediated vasculitis may be useful in dissecting mechanisms of microvascular injury.

  6. [Update Churg-Strauss syndrome].

    Science.gov (United States)

    Moosig, F; Hellmich, B

    2012-11-01

    The Churg-Strauss syndrome (CSS) is the rarest subtype of the so-called anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) and has the lowest frequency of ANCA-positivity (around 30%). In addition to asthma and blood eosinophilia, CSS is characterized by end-organ damage, which can be caused by either vasculitis and/or tissue infiltration of eosinophilic granulocytes. The CSS shares many etiological and clinical features of other hypereosinophilic syndromes. Recently, a distinct genetic background could be demonstrated for both the ANCA-positive and ANCA-negative subtypes of CSS as compared to the other two forms of AAV. Among other cytokines, interleukin-5 (IL-5) could be identified as a key mediator of eosinophilia. Therefore, recent clinical trials in CSS aimed to target IL-5. Outside of clinical trials, treatment of CSS is adapted to disease stage and activity, as recommended for other types of AAV.

  7. Churg-Strauss syndrome

    Directory of Open Access Journals (Sweden)

    Ilić Tatjana

    2002-01-01

    Full Text Available Churg-Strauss syndrome (CSS is medium blood vessels vasculitis with predilection for lungs in patients with bronchial asthma, chronic eosinophilic pneumonia and positive ANCA in the sera in 55-67%. This is a case report of a 60 years old female patient with bronchial asthma, peripheral pulmonary infiltrations, blood eosinophilia, xerophtalmia, tachycardia, chronic rhino sinusitis, polyneuropathia and negative immunological tests: CIC (PEG, CRYO, ANA (IIF, RF (agglutination and ANCA (IIF: pANCA and cANCA; ELISA: proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G. Eosinophilic infiltrates in the tissues tested by skin and salivary gland biopsies were not found. The patient had fulfilled five clinical diagnostic criteria and responded well to immunosuppressive therapy, so this case could be classified as the ANCA negative angiitis and granulomatous of CSS type.

  8. Antineutrophil cytoplasmic autoantibodies and myeloperoxidase autoantibodies in clinical expression of Churg-Strauss syndrome.

    Science.gov (United States)

    Healy, Bridget; Bibby, Susan; Steele, Richard; Weatherall, Mark; Nelson, Harold; Beasley, Richard

    2013-02-01

    The clinical significance of antineutrophil cytoplasmic antibodies (ANCAs) in the phenotypic expression of Churg-Strauss syndrome (CSS) is uncertain. We sought to investigate the relationship between ANCA status and the clinical expression of CSS in a case series derived from the US Food and Drug Administration's adverse events database. All cases of CSS reported to the US Food and Drug Administration from 1997 to April 2003 were reviewed. Information about basic demographics, suspect medication use, clinical manifestations, histologic findings, ANCA staining patterns, and the presence of antibodies to myeloperoxidase (anti-MPO) or proteinase 3 (anti-PR3) was recorded when available. There were 93 case reports of CSS with sufficient documentation, including ANCA status. There were 38 (40.9%) of 93 cases with positive ANCA results, of which 15 cases reported a positive ELISA, all of which were positive for anti-MPO. ANCA negativity was associated with an increased proportion of cardiac involvement (risk difference [RD], 38.2%; 95% CI, 25.3% to 51.0%), gastrointestinal involvement (RD, 25.5%; 95% CI, 13.9% to 37.0%), pulmonary infiltrates (odds ratio, 4.9; 95% CI, 1.5-16.2), and the outcome of a life-threatening event or death (RD, 30.9%; 95% CI, 18.7% to 43.1%) when compared with anti-MPO-positive cases. ANCA negativity was associated with a decreased proportion of peripheral neuropathy (odds ratio, 0.3; 95% CI, 0.07-0.9). These findings support the hypothesis that the presence or absence of autoantibodies influences the clinical expression and severity of CSS. Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  9. Tubular overexpression of gremlin induces renal damage susceptibility in mice.

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    Alejandra Droguett

    Full Text Available A growing number of patients are recognized worldwide to have chronic kidney disease. Glomerular and interstitial fibrosis are hallmarks of renal progression. However, fibrosis of the kidney remains an unresolved challenge, and its molecular mechanisms are still not fully understood. Gremlin is an embryogenic gene that has been shown to play a key role in nephrogenesis, and its expression is generally low in the normal adult kidney. However, gremlin expression is elevated in many human renal diseases, including diabetic nephropathy, pauci-immune glomerulonephritis and chronic allograft nephropathy. Several studies have proposed that gremlin may be involved in renal damage by acting as a downstream mediator of TGF-β. To examine the in vivo role of gremlin in kidney pathophysiology, we generated seven viable transgenic mouse lines expressing human gremlin (GREM1 specifically in renal proximal tubular epithelial cells under the control of an androgen-regulated promoter. These lines demonstrated 1.2- to 200-fold increased GREM1 expression. GREM1 transgenic mice presented a normal phenotype and were without proteinuria and renal function involvement. In response to the acute renal damage cause by folic acid nephrotoxicity, tubule-specific GREM1 transgenic mice developed increased proteinuria after 7 and 14 days compared with wild-type treated mice. At 14 days tubular lesions, such as dilatation, epithelium flattening and hyaline casts, with interstitial cell infiltration and mild fibrosis were significantly more prominent in transgenic mice than wild-type mice. Tubular GREM1 overexpression was correlated with the renal upregulation of profibrotic factors, such as TGF-β and αSMA, and with increased numbers of monocytes/macrophages and lymphocytes compared to wild-type mice. Taken together, our results suggest that GREM1-overexpressing mice have an increased susceptibility to renal damage, supporting the involvement of gremlin in renal damage

  10. Microscopic polyangiitis complicated with ileal involvement detected by double-balloon endoscopy: a case report.

    Science.gov (United States)

    Fukushima, Masashi; Inoue, Satoko; Ono, Yuichiro; Tamaki, Yoshitaka; Yoshimura, Hajime; Imai, Yukihiro; Inokuma, Tetsuro

    2013-03-02

    Microscopic polyangiitis is characterized by pauci-immune, necrotizing small-vessel vasculitis and an anti-neutrophil cytoplasmic antibody-associated vasculitis. Although gastrointestinal involvement in microscopic polyangiitis is not rare, endoscopic observation of it is extremely rare. To the best of our knowledge, this is the first case report of small intestinal involvement in microscopic polyangiitis detected and followed up by double-balloon endoscopy. A 70-year-old Japanese woman was transferred to our hospital for close examination of suspected small intestinal lymphoma. Retrograde double-balloon endoscopy revealed various forms of ulcers with redness and edema in the ileum. Histological findings suggested ischemic changes. Because mononeuritis multiplex and a fever spike appeared later, vasculitis was suspected. The perinuclear anti-neutrophil cytoplasmic antibody titer was elevated. Nerve biopsy results suggested vasculitis. From these findings, microscopic polyangiitis was diagnosed. It was suggested that microscopic polyangiitis caused the intestinal involvement. Intravenous pulse cyclophosphamide and oral predonisolone were started. After treatment, perinuclear anti-neutrophil cytoplasmic antibodies decreased to the normal range. Retrograde double-balloon endoscopy after treatment showed ulcer scars and no ulcer. The cause of gastrointestinal involvement in microscopic polyangiitis is ischemia due to vasculitis. It is difficult to diagnose small-vessel vasculitis by endoscopic biopsy. Although histological evidence of microscopic polyangiitis is important, the treatment should not be delayed by repeating the biopsy, because such delay can result in adverse sequela.This case report shows that microscopic polyangiitis should be considered as a differential diagnosis when small intestinal changes like those in the present case are observed by endoscopy.

  11. 75 FR 54177 - Notice of Availability of Draft Environmental Impact Statement for the Tonopah Solar Energy...

    Science.gov (United States)

    2010-09-03

    ... Statement for the Tonopah Solar Energy Crescent Dunes Solar Energy Project, Nye County, NV AGENCY: Bureau of... Environmental Impact Statement (EIS) for the Crescent Dunes Solar Energy Project, Nye County, Nevada, and by... considered, the BLM must receive written comments on the Crescent Dunes Solar Energy Project Draft EIS within...

  12. CHEMICAL AND FERMENTATIVE CHARACTERISTICS OF ELEPHANT GRASS ENSILED WITH INCREAS-ING LEVELS OF DENIDRATED CASHEW FRUIT BY-PRODUCT CARACTERÍSTICAS QUÍMICAS E FERMENTATIVAS DO CAPIM-ELEFANTE ENSILADO COM NÍVEIS CRESCENTES DE SUBPRODUTO DA AGROINDÚSTRIA DO CAJU

    Directory of Open Access Journals (Sweden)

    Warley Efrem Campos

    2007-12-01

    Full Text Available

    Nutritive value of silages of Elephant grass (Pen-nisetum   purpureum, Schum. mixed with 0; 3.5%; 7.0%; 10.5% and 14.0 %  of dehydrated by product from juice industry of cashew fruit (Anacardium occidentale, L (DBC was determined. A randomized design was used with four replicates. Silages were opened after 65 days and samples taken for analysis of dry matter (DM, crude protein (CP, neutral detergent fiber (NDF, acid detergent fiber (ADF, hemicellulose HCEL, cellulose (CEL, lig-nin (LIG, crude energy (CE, ash, neutral detergent inso-luble nitrogen (NDIN and acid detergent insoluble nitro-gen (ADIN. Were also analyzed, pH, ammonia nitrogen and organic acids (lactic, acetic, butyric and propionic. Regarding fermentative parameters, there was an expected decrease in pH and the increasing levels of DBC did not affect the concentrations of N-NH3/NT and organic acids. It is concluded that dehydrated cashew by product can be ensiled along with Elephant grass without altering its fer-mentative characteristics. On the other side, the increased cell walls and ADIN contents of the silage may affect its nutritional value.

    Key-words: Cashew byproducts, nutritive value, tropical grass.

    O trabalho foi desenvolvido com o objetivo de se avaliar o valor nutritivo das silagens de capim-elefante (Pennisetum purpureum, Schum. com adição de 0%; 3,5%; 7%; 10,% e 14% do subproduto do pseudofruto do caju (Anacardium occidentale, L. desidratado (subproduto da agroindústria do suco de caju. Utilizou-se o delineamento inteiramente casualizado, com quatro repetições. Após 65 dias, os silos foram abertos e coletadas amostras para determinação dos teores de matéria seca (MS, proteína bruta (PB, fibra em detergente neutro (FDN, fibra em detergente ácido (FDA, hemicelulose (HCEL, celulose (CEL, lignina (LIG, energia bruta (EB, cinzas, nitrogênio insolúvel em detergente neutro (NIDN e nitrogênio insolúvel em detergente ácido (NIDA. Para avaliar as características fermentativas das silagens, determinaram-se os valores de pH e os teores de nitrogênio amoniacal (% do nitrogênio total e dos ácidos lático, acético, butírico e propiônico. A adição do subproduto do pseudofruto do caju desidratado (SPCD acarretou o aumento dos teores de MS, PB, FDA, LIG, NIDN e NIDA. Para os parâmetros fermentativos, observou-se redução dos valores de pH, porém não se registrou influência dos níveis de adição do SPCD sobre os teores de N-NH3/NT e ácidos orgânicos. Conclui-se que o subproduto do pseudofruto do caju desidratado pode ser ensilado com o capim-elefante, sem comprometer as características fermentativas das silagens de capim-elefante. Porém, o aumento nos componentes da parede celular e do NIDA pode comprometer o valor nutri-cional do ensilado final.

    Palavras-chaves: Gramínea tropical, subprodutos do caju, valor nutritivo.

  13. Efeito de doses crescentes de nitrogênio, fósforo e potássio sôbre a produção de mandioca em solos de baixa e alta fertilidade Responses of cassava to increasing doses of nitrogen, phosphorus and potassium

    Directory of Open Access Journals (Sweden)

    Jairo Ribeiro da Silva

    1968-01-01

    Full Text Available Para estudar os efeitos de adubações com nitrogênio, fósforo e potássio sôbre a produção de mandioca, conduziram-se, no Estado de São Paulo, duas experiências em solos arenosos de baixa fertilidade e uma em terra-roxa-misturada bastante fértil. Nos três casos, os solos não foram adubados no ano agrícola anterior ao da instalação das experiências. Nestas, pequena parte das doses de fósforo e potássio foi aplicada nos sulcos de plantio, e o resto, em conjunto com as doses totais de nitrogênio, durante o desenvolvimento das plantas, em sulcos laterais aos de plantio. Nos solos arenosos, os efeitos do nitrogênio e do fósforo foram muito pequenos, ao passo que o do potássio foi bastante elevado. Na terra-roxa-misturada, as respostas médias aos três elementos foram pequenas; contudo, a interação negativa fósforo x potássio mostrou que, na ausência um do outro, êstes elementos, sobretudo o segundo, proporcionaram aumentos apreciáveis de produção.Three experiments were conducted in the State of São Paulo to study the responses of cassava (Manihot esculenta Crantz to nitrogen, phosphorus and potassium. Effects of nitrogen and phosphorus were small in all of the experiments, while potassium increased significantly the root yields in two of them, located on poor sandy soils.

  14. Híbridos de Sorgo (Sorghum bicolor (L. Moench Cultivados sob Níveis Crescentes de Adubação: Rendimento, Proteína Bruta e Digestibilidade in Vitro Sorghum (Sorghum bicolor (L. Moench Hybrids Cultivated under Increasing Fertilization Levels: Yield, Crude Protein and in Vitro Digestibility

    Directory of Open Access Journals (Sweden)

    Miguel Marques Gontijo Neto

    2002-07-01

    Full Text Available Objetivou-se com este trabalho avaliar o rendimento forrageiro, os teores de proteína bruta (PB e a digestibilidade in vitro de matéria seca (DIVMS de cinco híbridos de sorgo forrageiro (AG-2002, AG-2005E, AG-X202, AG-X213 e AG-X215, cultivados sob quatro níveis de adubação NPK. Utilizou-se o delineamento em blocos casualizados, em um esquema fatorial 5 x 4 com quatro repetições. Os híbridos avaliados apresentaram altas produções médias de MS/ ha e resposta linear positiva, em função da adubação, ressalvando a alta produtividade (15,47 t/ha nas parcelas sem adubação, em função da fertilidade do solo e das condições climáticas. Os híbridos apresentaram respostas diferenciadas quanto aos teores de PB, em função da adubação, predominando respostas quadráticas, determinando o comportamento quadrático da produção de proteína bruta. A DIVMS e a produção de matéria seca digestiva apresentaram respostas lineares positivas em função da adubação, sendo a produção de matéria seca digestível fortemente correlacionada (0,91** com o aumento da produção de MS/ha.The objective of this research was to evaluate the forage yield, crude protein (CP contents and dry matter (DM in vitro digestibility of five forage sorghum hybrids (AG-2002, AG-2005E, AG-X202, AG-X213 e AG-X215, cultivated under four NPK fertilization levels. A randomized blocks design, in a 5 x 4 factorial scheme, with four replicates, was used. The evaluated hybrids showed high average DM/ha yield and positive linear answer in function of fertilization, except for the high productivity (15.47 t/ha in the plots without fertilization, in function of soil fertilization and climatic conditions. The hybrids showed different answers for the CP contents, according to the fertilization, in a quadratic way, determining the quadratic behavior for the crude protein yield. IVDMD and digestive dry matter yield showed positive linear answers in function of fertilization, and the digestible dry matter yield was highly correlated (0.91** with the increase of DM/ha yield.

  15. Desempenho e características da carcaça de tourinhos Santa Gertrudes confinados, recebendo dietas com alto concentrado e níveis crescentes de polpa cítrica peletizada Feedlot performance and carcass characteristics of Santa Gertrudis bulls, fed high concentrate diets with increasing levels of dehydrated citrus pulp pellets

    Directory of Open Access Journals (Sweden)

    Wignez Henrique

    2004-04-01

    Full Text Available O experimento foi desenvolvido com o objetivo de avaliar o efeito da substituição do milho pela polpa cítrica peletizada sobre o desempenho e as características da carcaça de tourinhos Santa Gertrudes confinados. Vinte e oito animais, com nove meses de idade e peso inicial de 277 kg, foram confinados em baias individuais. O período experimental foi de 92 dias, após 21 dias de adaptação. Os animais receberam dietas contendo 20% da matéria seca como silagem de milho, com 40% de grãos. Foram testados os níveis de 0, 25, 40 e 55% de participação da polpa cítrica peletizada na matéria seca da dieta. Não houve efeito do nível de polpa cítrica na dieta sobre ganho de peso, ingestão diária de matéria seca, eficiência alimentar, rendimento de carcaça, área de olho de lombo e peso da gordura renal-pélvica-inguinal. Os pesos do fígado e da carcaça foram significativamente maiores com o aumento da polpa cítrica na dieta, que também determinou decréscimo linear na espessura de gordura sobre a 12ª costela. O pH das fezes foi semelhante entre os níveis de participação da polpa cítrica. Não foi verificada a ocorrência de abscessos no fígado em nenhum tratamento, apesar da dieta conter alto teor de concentrado. A polpa cítrica peletizada pode compor até 55% da matéria seca de dietas, substituindo o milho em grão, para tourinhos em terminação recebendo altos níveis de concentrado, apenas com diminuição da espessura de gordura.The experiment was developed to evaluate the effect of the replacement of corn grain by dehydrated citrus pulp pellets on the performance and carcass characteristics of Santa Gertrudis young bulls fed high concentrate diets. Twenty-eight bulls, with average age of nine months and an initial weight of 277 kg, were kept in individual pens and fed during 92 days, after 21 days of adaptation. The animals were fed a diet with 20% of the dry matter as corn silage, with 40% of grain. Treatments evaluated included levels of 0, 25, 40 and 55% of dehydrated citrus pulp pellets in the dry matter diet. There was no effect of citrus pulp level on the average daily gain, daily dry matter intake, feed efficiency, carcass dressing, Longissimus muscle area and the kidney, pelvic and inguinal fat. The increasing level of citrus pulp on the diet decreased linearly the backfat thickness and increased linearly the liver weight and carcass weight. The feces pH was similar for all the citrus pulp levels. Liver abscess were not detected, although the diet had high concentrate level. The dehydrated citrus pulp pellets can compound until 55% of dry matter diet, replacing corn grain to finishing young bulls fed high concentrate diets, with a small decrease in subcutaneous fat.

  16. Crescimento vegetativo e produção de cafeeiros (Coffea arabica L. recepados em duas épocas, conduzidos em espaçamentos crescentes Vegetative growth and yield of coffee plants (Coffea arabica L. in two different pruning times, conducted at different spacings

    Directory of Open Access Journals (Sweden)

    Sérgio Parreiras Pereira

    2007-06-01

    Full Text Available O experimento foi instalado na Fazenda Experimental da Empresa de Pesquisa Agropecuária de Minas Gerais - EPAMIG em Machado, Sul de Minas Gerais, em 1992, com o objetivo de avaliar as conseqüências da redução dos espaçamentos entre as linhas e entre as plantas na linha de plantio sobre a produção e a fenologia do cafeeiro(Coffea arabica L.. O delineamento experimental foi o blocos casualizados - DBC, em um arranjo fatorial 4 x 3 com parcela subdividida, sendo quatro distâncias entre as linhas (2,0; 2,5; 3,0 e 3,5 m e três distâncias entre as plantas na linha de plantio (0,5; 0,75; 1,0 m, e duas épocas de poda (uma precoce feita logo após a colheita em de julho 2002 e a outra tardia em de janeiro de 2003, totalizando 24 tratamentos com três repetições. Em julho de 2002 e em janeiro de 2003 foi realizada a poda tipo "recepa", na qual foram conduzidas duas brotações por planta. Em agosto de 2004, avaliou-se o crescimento dos componentes vegetativos e a produção das parcelas. Os espaçamentos adotados não influenciaram o crescimento de nenhum dos componentes vegetativos das brotações no período avaliado. Todas as características vegetativas foram influenciadas positivamente pela adoção da poda precoce, assim como a produtividade da primeira colheita realizada após a poda, que foi também influenciada positivamente pela adoção de espaçamentos mais adensados. Os cafeeiros que foram submetidos à poda tardia não produziram, em julho de 2004, como aqueles podados precocemente.The experiment was established in the Empresa de Pesquisa Agropecuária de Minas Gerais - Epamig Experiment Station, located in the city of Machado, south of the Minas Gerais state, Brazil, in the year of 1992, with the objective of evaluating the consequences of the reduction on planting spaces among rows and among plants, upon beans yield and plant phenology (Coffea arabica L.. The experimental design used was a 4x 3 factorial with split plot at four distances between planting rows (2,0; 2,5; 3,0 e 3,5 m and three distances among plants in the row (0,5; 0,75 e 1,0 m, and two different pruning times (one precociously conducted just after the harvest, on july 2002, and the other latter on january 2003, making a total 24 treatments arranged in randomized blocks with three replicates. In july 2002 and january 2003 a drastic pruning was clone and conducing two sprouts per plant. Vegetative growth and beans yield were evaluated in august 2004. Coffee plant spacing did not affected growth of any of the vegetative components of sprouting, during the evaluated period. All the vegetative characteristics were positively affected by the early pruning procedure, as well as the beans yield of the first harvest after pruning, which also showed to be positively influenced by the adoption of a narrower spacing plant. The coffee plants which were submitted to late prunning, had lancer bean yield in july 2004 as those precociously prunned.

  17. Composição tecidual e centesimal e teor de colesterol da carne de cordeiros terminados em confinamento com dietas contendo níveis crescentes de resíduo úmido de cervejaria Tissue and centesimal composition and cholesterol of the meat of lambs feedlot with diets with different levels of brewery's residue

    OpenAIRE

    Sérgio Carvalho; Mariana Augusta Brochier

    2008-01-01

    Este estudo teve como objetivo avaliar a influência de diferentes níveis de substituição do alimento concentrado por resíduo úmido de cervejaria sobre a composição tecidual, a composição centesimal e o teor de colesterol da carne de cordeiros terminados em confinamento. Foram utilizados 25 cordeiros, machos, não-castrados, da raça Texel, distribuídos aleatoriamente em cinco tratamentos compostos por níveis de substituição do alimento concentrado por resíduo úmido de cervejaria, sendo: 0%, 25%...

  18. RU’YAT AL-HILĀL DENGAN TEKNOLOGI : Telaah Pelaksanaan Ru’yat al-Hilāl di Baitul Hilal Teluk Kemang Malaysia

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    Dito Alif Pratama

    2016-10-01

    Full Text Available Baitul Hilal Teluk Kemang which is located at coordinate latitude 2 ° 26 '44' in the North and longitude 101° 51'21' in the East, is one of the good record crescent sighting observation center in Malaysia. The result of the study is as follows, firstly, the method of crescent observation at Baitul Hilal seems quite effective since it is located in a strategic and suitable place for crescent observation activity. Baitul Hilal is also supported by some sophisticated technology such as telescope and DSLR camera operated by some crescent observers who are officially certified by the Malaysian government. Secondly, Baitul Hilal has contributed to crescent observation development in Malaysia. Baitul Hilal also provides with the astronomical data based on monthly crescent activity as an additional data for crescent researcher to analyze the imkᾱn al-rukyah criterion.

  19. Spotlight on rituximab in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis: current perspectives

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    Moog P

    2015-11-01

    Full Text Available Philipp Moog, Klaus Thuermel Abteilung für Nephrologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany Abstract: A 54-year-old patient presented to his general practitioner because of strong muscle pain in both thighs. Inflammatory parameters (CRP 16.3 mg/dL and white blood cells (15 g/L were elevated. The patient reported a weight loss of 10 kg in 4 weeks. There was no fever or any other specific symptoms. Urine dipstick examination and computed tomography of the chest were unremarkable. Because of increasing symptoms, the patient was referred to our department. Magnetic resonance tomography showed diffuse inflammatory changes of the muscles of both thighs. Neurological examination and electrophysiology revealed axonal sensorimotor neuropathy and ground-glass opacities of both lungs had occurred. Serum creatinine increased to 229 µmol/L within a few days, with proteinuria of 3.3 g/g creatinine. Kidney biopsy showed diffuse pauci-immune proliferative glomerulonephritis. Proteinase 3-specific antineutrophil cytoplasmic antibodies were markedly increased. Birmingham Vasculitis Activity Score was 35. Within 2 days, serum creatinine further increased to 495 µmol/L. Plasma exchange, high-dose glucocorticosteroids, and hemodialysis were started. The patient received cyclophosphamide 1 g twice and rituximab 375 mg/m2 four times according to the RITUXVAS protocol. Despite ongoing therapy, hemodialysis could not be withdrawn and had to be continued over 3 weeks until diuresis normalized. Glucocorticosteroids were tapered to 20 mg after 2 months, and serum creatinine was 133 µmol/L. However, nephritic urinary sediment reappeared. Another dose of 1 g cyclophosphamide was given, and glucocorticosteroids were raised for another 4 weeks. After 6 months, the daily prednisolone dose was able to be tapered to 5 mg. Serum creatinine was 124 µmol/L, proteinuria further decreased to 382 mg/g creatinine, and the Birmingham

  20. 76 FR 2680 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2011-01-14

    ... Open-Pit Gold Mining and Processing Operations, Crescent Valley, Lander and Eureka Counties, NV, Wait..., CA, Eagle Mountain Pumped Storage Hydroelectric Project, Licensing Application for Eagle Mountain...

  1. Ganhos de peso, taxas de deposição e composição química corporal de tourinhos Santa Gertrudes confinados, recebendo alto concentrado e níveis crescentes de polpa cítrica peletizada Live weight gains, deposition rates and body chemical composition of Santa Gertrudis young bulls, fed high concentrate diets with increasing levels of dehydrated citrus pulp pellets

    Directory of Open Access Journals (Sweden)

    Wignez Henrique

    2006-06-01

    Full Text Available Objetivou-se avaliar a substituição do milho em grão pela polpa cítrica peletizada e seus efeitos sobre os ganhos de peso, as taxas de deposição e a composição química corporal de tourinhos Santa Gertrudes em confinamento. Vinte e oito animais (idade média de nove meses e peso inicial de 277 kg foram mantidos em baias individuais durante 92 dias, após 21 dias de adaptação. Os animais receberam dietas contendo 20% da MS como silagem de milho que continha 40% de grãos. Foram testados os níveis de 0, 25, 40 e 55% de participação da polpa cítrica peletizada na MS da dieta. A composição química corporal foi estimada a partir de equações desenvolvidas para a mesma raça, utilizando-se a composição química do corte da 9-10-11ª costelas. A participação da polpa cítrica peletizada não afetou significativamente o peso corporal final (449 kg e os ganhos diários de peso corporal (1,50 kg, de corpo vazio (1,26 kg e de carcaça (0,78 kg. Não houve diferença entre tratamentos para as taxas diárias de deposição de água (0,374 kg, EE (0,589 kg, proteína (0,253 kg, minerais (0,040 kg e energia (6,934 Mcal e, conseqüentemente, a composição química corporal final foi similar entre os animais recebendo diferentes níveis de polpa cítrica na dieta. A substituição do milho em grão por polpa cítrica peletizada, até 55% da MS, em dietas para tourinhos em terminação recebendo altos níveis de concentrado, não altera os ganhos de peso, as taxas de deposição e a composição química corporal desses animais.The objective of this trial was to evaluate the effects of replacing corn grain with dehydrated citrus pulp pellets on body weight gains, deposition rates of nutrients and body chemical composition of Santa Gertrudis young bulls. Twenty-eight animals averaging nine months of age and initial body weight of 277 kg were kept in individual pens during 92 days after 21 days of adaptation. Animals were fed a diet containing 20% (DM basis of 40%-grain corn silage. The following dietary levels of dehydrated citrus pulp pellets (% dry matter were fed: 0, 25, 40 or 55%. Body chemical composition was estimated from equations developed for Santa Gertrudis using the chemical composition of 9-10-11th ribs cut. Increasing levels of citrus pulp had no significant effects on final body weight (449 kg and on daily gains of body weight (1.50 kg, empty body (1.26 kg and carcass (0.78 kg. There were no significant differences among treatments on daily rates of deposition of water (0.374 kg, EE (0.589 kg, protein (0.253 kg, ash (0.040 kg and energy (6.934 Mcal. Therefore, final body chemical composition was similar across diets. Dehydrated citrus pulp pellets can replace corn grain, up to 55% of diet DM, with no detrimental effects on daily gains, deposition rates and body chemical composition of finishing Santa Gertrudis young bulls fed high concentrate diets.

  2. Efeito de dietas com níveis crescentes de caroço de algodão integral sobre a composição química e o perfil de ácidos graxos da carne de cordeiros Santa Inês Effect of diets with increasing levels of whole cotton seed on chemical composition and fatty acid profile of Santa Inez (Santa Inês lamb meat

    Directory of Open Access Journals (Sweden)

    Marta Suely Madruga

    2008-08-01

    Full Text Available Esta pesquisa foi realizada com o objetivo de avaliar o efeito da inclusão (0, 20, 30 e 40% de caroço de algodão integral (Gossypium hirsutum na dieta sobre a composição química e o perfil de ácidos graxos da carne de cordeiros Santa Inês. Foram utilizados 24 cordeiros machos não-castrados (peso corporal inicial de 19,0 ± 0,2 kg e 4 meses de idade, todos criados em regime de confinamento em baias individuais. Os níveis de caroço de algodão integral não afetaram a composição centesimal e os percentuais de colesterol e fosfolipídios da carne ovina. Entretanto, houve diferença entre os percentuais dos ácidos graxos mirístico, palmítico e linolênico e entre a relação C18:0 + C18:1 / C16:0. Do ponto de vista nutricional, a utilização de caroço de algodão integral na dieta pode ser recomendada, durante períodos curtos, em níveis de até 40% para ovinos em terminação. Ressalta-se que o caroço de algodão integral é um subproduto economicamente viável por apresentar baixo custo de produção em comparação ao milho e à soja.The objective of this research was to evaluate the effect of inclusion (0, 20, 30 and 40% of whole cottonseed (Gossypium hirsutum in the diet on chemical composition and fatty acids profile of Santa Inez sheep meat. Twenty four no castrated male sheep were used, (initial 19.0 ± 0.2 kg BW and 4 month old, all kept in confinement regime in individual stalls. The levels of whole cottonseed did not affect chemical composition and the percentages of cholesterol and phospholipids of the lamb meat. However, there was difference among the percentages of the miristic, palmitic and linolenic fatty acids and also to the relationship C18:0 + C18:1 / C16:0. At nutritional point of view, the utilization of whole cottonseed could be recommended, during short periods, up to the level of 40% for finishing animals. In addition, whole cottonseed is a by-product economically viable for presenting low production cost as compared to corn and soybean.

  3. DYNAMICS OF THE RUMINAL FERMENTATION IN SHEEP FEEDING WITH RATION CONTAINING DIFFERENT LEVELS OF CASHEW BY-PRODUCTS (Anacardium occidentale Efecto de la inclusion en los níveles crescentes del subproducto de caju (Anacardium occidentale L. en la dinámica de la fermentacion ruminal de ovinos DINÂMICA DA FERMENTAÇÃO RUMINAL EM OVINOS ALIMENTADOS COM RAÇÕES CONTENDO DIFERENTES NÍVEIS DE COPRODUTOS DE CAJU (Anacardium occidentale

    Directory of Open Access Journals (Sweden)

    Marcos Cláudio Rogério

    2009-07-01

    Full Text Available

    The study aimed to evaluate the inclusion of cashew by-product (Anacardium occidentale L. on the ammoniac nitrogen concentrations (N-NH3, pH and vollatile fatty acids concentrations (VFA of the ruminal fluid, in sheep that received diets containing the cited by-product. Twenty male, entire sheep had been distributed in four treatments with different levels of cashew by-product inclusion (zero; 19%; 38%; 52% in a randomized block design, in a split-plot project, having in the parcels the diets and the sub-parcels the times of collection (zero, two, five, eight hours after-feeding with five replications. PH was remained inside of the normal standards cited by same literature in the raised cashew by-product inclusions. Diets with zero and 52% had gotten the biggest concentrations of N-NH3. The molar ratio of the AGV in the ruminal liquid in the diets with cashew by-product was typical of rich diets in voluminous. The relation acetate: propionate was not affected by the inclusion of the cashew by-product. The inclusion of the cashew by-product in up to 19 % of the dietary total presented better resulted in that it says respect to the parameters analyzed in this work.

    KEY WORDS: Ammoniac nitrogen, Ovis aries, pH, parameters ruminate, ruminants, volatile fatty acids.

    El estudio apunto evaluar la inclusión del subproducto de caju (Anacardium occidentale en la concentración de nitrogeno amoniacal (N-NH3, el pH y las concentraciones de los acidos grasos vollatiles (AGV en el liquido ruminal de ovinos que recibieron las dietas experimentales isofibrosas y isoproteic que contiene el subproducto en el niveles crescientes. Veinte ovinos machos habon distribuido en cuatro tratamientos con niveles de inclusion del subproducto de caju (cero, 19%, 38%, 52% en un diseno de bloque al azar, en parcelas sudivididas, teniendo en los parcelas las dietas y los su-parcelas los tiempos de la coleccion (cero, dos, cinco y ocho horas despues de alimentacion con cinco replicas. El pH se mantuvo dentro de los estándares normales citados en la literatura, cuando en alta inclusion del subproducto de caju. Los tratamientos cero y el 52% presentaron las mayores concentraciones de N-NH3. La proporción de moles de AGV en lo liquido ruminal en las dietas con subproducto de caju era típica de dietas ricas en volumoso. La relacion acetato: propionato no se afectou por la inclusión del subproducto del caju. La inclusión del subproducto de caju en 19% de la dieta total presento mejores resultados en los parámetros analizados en este trabajo.

    O presente estudo foi desenvolvido para avaliar a influência da inclusão de diferentes níveis do coproduto do processamento do caju (Anacardium occidentale L. sobre a concentração de nitrogênio amoniacal (N-NH3 em mg/100 mL, pH e concentrações molares de ácidos graxos voláteis (AGVs do líquido ruminal, em ovinos recebendo dietas experimentais isofibrosas e isoproteicas. Distribuíram-se vinte ovinos machos, inteiros em quatro tratamentos de inclusão do coproduto de caju (zero %; 19%; 38%; 52%, segundo delineamento em blocos ao acaso, em esquema de parcelas subdivididas, em que as parcelas eram as dietas e as subparcelas os tempos de colheita (zero, duas, cinco, oito horas pós-prandial com cinco repetições. O pH manteve-se dentro dos padrões citados na literatura, mesmo diante de elevadas inclusões de coproduto de caju. Os tratamentos com zero % e 52% apresentaram as maiores concentrações de N-NH3. A proporção molar dos AGVs no líquido ruminal dos ovinos alimentados com rações com o coproduto de caju foi típica de dietas ricas em volumosos. A relação acetato:propionato não foi afetada pela inclusão do coderivado de caju. A inclusão do coproduto de caju em até 19 % na ração apresentou os melhores resultados no que diz respeito aos parâmetros analisados neste trabalho.

    PALAVRAS-CHAVES: Ácidos graxos voláteis, nitrogênio amoniacal, Ovis aries, pH, parâmetros ruminais, ruminantes.

  4. Heart transplantation in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Groh, Matthieu; Masciocco, Gabriella; Kirchner, Elizabeth; Kristen, Arnt; Pellegrini, Carlo; Varnous, Shaïda; Bortman, Guillermo; Rosenberg, Mark; Brucato, Antonio; Waterworth, Paul; Bonacina, Edgardo; Facchetti, Fabio; Calabrese, Leonard; Gregorini, Gina; Scali, Juan Jose; Starling, Randall; Frigerio, Maria; D'Armini, Andrea Maria; Guillevin, Loïc

    2014-08-01

    Heart involvement is the leading cause of death of patients with eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg-Strauss syndrome) and is more frequent in anti-neutrophil cytoplasm antibody (ANCA)-negative patients. Post-transplant outcome has only been reported once. We conducted a retrospective international multicenter study. Patients satisfying the criteria of the American College of Rheumatology and/or revised Chapel Hill Consensus Conference Nomenclature were identified by collaborating vasculitis and transplant specialists, and the help of the Churg-Strauss Syndrome Association. Nine ANCA(-) patients who received transplants between October 1987 and December 2009 were identified. The vasculitis and cardiomyopathy diagnoses were concomitant for 5 patients and separated by 12 to 288 months for the remaining 4 patients. Despite ongoing immunosuppression, histologic examination of 7 (78%) patients' explanted hearts showed histologic patterns suggestive of active vasculitis. The overall 5-year survival rate was low (57%), but rose to 80% when considering only the 6 patients transplanted during the last decade. After survival lasting 3 to 60 months, 4 (44%) patients died sudden deaths. The search for EGPA-related cardiomyopathy is mandatory early in the course of this type of vasculitis. Indeed, prompt treatment with corticosteroids and cyclophosphamide may achieve restore cardiac function. Most patients in this series were undertreated. For patients with refractory EGPA, heart transplantation should be performed, which carries a fair prognosis. No optimal immunosuppressive strategy has yet been identified. Copyright © 2014 International Society for Heart and Lung Transplantation. All rights reserved.

  5. Churg-Strauss vasculitis and idiopathic hypereosinophyl syndrome: role of molecular biology in the differential diagnosis of hypereosinophyl syndrome

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    A. d'Ascanio

    2011-09-01

    Full Text Available Objective: Hypereosinophilic syndromes are a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia, tissue eosinophilia, or both, resulting in a wide variety of clinical manifestations, often without an identifiable cause. Churg-Strauss syndrome is a systemic vasculitis characterized by prominent peripheral eosinophilia, asthma and systemic involvement. The presence of mild to severe eosinophilia and systemic involvement raise the search of many trigger factor that need to be ruled out. Distinguishing CSS from idiopathic hypereosinophilic syndrome may be particularly challenging, especially in ANCA negative patients. Methods: The aim of the present study was to present a small case series of patients referred to a Rheumatology Unit for mild to severe eosinophilia and signs and symptoms of systemic involvement and to outline the clinical significance of molecular biology in the work-up of hypereosinophilia. Results: Eleven patients with moderate to severe peripheral eosinophylia, were referred to our Unit from 1996 to 2007. Female to male ratio was 7/4, mean age 40.54 (range 22-75. Three out of eleven patients resulted positive for molecular biology. The diagnosis of idiopathic hypereosinophylia was confirmed in one out of three on the basis of the clinical picture and bone marrow biopsy. Conclusions: Molecular biology may be useful in the screening and in the follow-up of a new hypereosinophylic patient.

  6. Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

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    Omar I. Saadah

    2013-01-01

    Full Text Available Background. It is unusual for the antineutrophil cytoplasmic antibody with cytoplasmic pattern (cANCA to present in patients with inflammatory bowel disease (IBD without vasculitis. The purpose of this study was to describe the occurrence and characteristics of pediatrics IBD with cANCA. Methods. A retrospective review of pediatric IBD associated with cANCA serology in patients from King Abdulaziz University Hospital, Saudi Arabia, between September 2002 and February 2012. Results. Out of 131 patients with IBD screened for cANCAs, cANCA was positive in 7 (5.3% patients of whom 4 had ulcerative colitis and 3 had Crohn's disease. The median age was 8.8 years (2–14.8 years. Six (86% were males. Of the 7 patients, 5 (71% were Saudi Arabians and 2 were of Indian ethnicity. The most common symptoms were diarrhea, abdominal pain, weight loss, and rectal bleeding. None had family history or clinical features suggestive of vasculitis involving renal and respiratory systems. No difference in the disease location or severity was observed between cANCA positive and cANCA negative patients apart from male preponderance in cANCA positive patients. Conclusion. The occurrence of cANCA in pediatric IBD is rare. Apart from male preponderance, there were no peculiar characteristics for the cANCA positive patients.

  7. 75 FR 72836 - Notice of Availability of Final Environmental Impact Statement for the Tonopah Solar Energy...

    Science.gov (United States)

    2010-11-26

    ... Statement for the Tonopah Solar Energy Crescent Dunes Solar Energy Project, Nye County, NV AGENCY: Bureau of... Statement (EIS) for the Crescent Dunes Solar Energy Project, Nye County, Nevada, and by this notice is... . SUPPLEMENTARY INFORMATION: Tonopah Solar Energy, LLC applied to the BLM for a 7,680-acre right-of-way (ROW) on...

  8. Crack Propagation in Compressor Rotor Blade

    Science.gov (United States)

    2012-08-01

    Aerospace: Research and Development 86 Blenheim Crescent Ruislip, Middlesex HA4 7HB United Kingdom October 20, 2010 Distribution... Middlesex HA4 7HB United Kingdom April 20, 2011 Distribution A: Approved for public release; distribution is unlimited...September 2010, (Grant FA8655-10-1-3062), European Office of Aerospace: Research and Development, 86 Blenheim Crescent, Ruislip, Middlesex HA4 7HB

  9. Progranulin antibodies in autoimmune diseases.

    Science.gov (United States)

    Thurner, Lorenz; Preuss, Klaus-Dieter; Fadle, Natalie; Regitz, Evi; Klemm, Philipp; Zaks, Marina; Kemele, Maria; Hasenfus, Andrea; Csernok, Elena; Gross, Wolfgang L; Pasquali, Jean-Louis; Martin, Thierry; Bohle, Rainer Maria; Pfreundschuh, Michael

    2013-05-01

    Systemic vasculitides constitute a heterogeneous group of diseases. Autoimmunity mediated by B lymphocytes and their humoral effector mechanisms play a major role in ANCA-associated vasculitis (AAV) as well as in non-ANCA associated primary systemic vasculitides and in the different types of autoimmune connective tissue disorders and rheumatoid arthritis. In order to detect autoantibodies in systemic vasculitides, we screened protein macroarrays of human cDNA expression libraries with sera from patients with ANCA-associated and ANCA-negative primary systemic vasculitides. This approach led to the identification of antibodies against progranulin, a 88 kDA secreted glycoprotein with strong anti-inflammatory activity in the course of disease of giant-cell arteritis/polymyalgia rheumatica (14/65), Takayasu's arteritis (4/13), classical panarteritis nodosa (4/10), Behcet's disease (2/6) and in the course of disease in granulomatosis with polyangiitis (31/75), Churg-Strauss syndrome (7/23) and in microscopic polyangiitis (7/19). In extended screenings the progranulin antibodies were also detected in other autoimmune diseases such as systemic lupus erythematosus (39/91) and rheumatoid arthritis (16/44). Progranulin antibodies were detected only in 1 of 97 healthy controls. Anti-progranulin positive patients with systemic vasculitides, systemic lupus erythematosus or rheumatoid arthritis had significant lower progranulin plasma levels, indicating a neutralizing effect. In light of the anti-inflammatory effects of progranulin, progranulin antibodies might exert pro-inflammatory effects thus contributing to the pathogenesis of the respective autoimmune diseases and might serve as a marker for disease activity. This hypothesis is supported by the fact that a positive progranulin antibody status was associated with active disease in granulomatosis with polyangiitis. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome.

    Science.gov (United States)

    Khoury, P; Zagallo, P; Talar-Williams, C; Santos, C S; Dinerman, E; Holland, N C; Klion, A D

    2012-09-01

    Churg-Strauss syndrome (CSS) and hypereosinophilic syndrome (HES) overlap considerably in clinical presentation. A reliable means of distinguishing between these groups of patients is needed, especially in the setting of glucocorticoid therapy. A retrospective chart review of 276 adult subjects referred for evaluation of eosinophilia > 1500/μl was performed, and subjects with a documented secondary cause of eosinophilia or a PDGFR -positive myeloproliferative neoplasm were excluded. The remaining subjects were assessed for the presence of American College of Rheumatology (ACR) criteria. Laboratory and clinical parameters were compared between subjects with biopsy-proven vasculitis (CSS; n = 8), ≥4 ACR criteria (probable CSS; n = 21), HES with asthma and/or sinusitis without other CSS-defining criteria (HESwAS; n = 20), HES without asthma or sinusitis (HES; n = 18), and normal controls (n = 8). Serum biomarkers reported to be associated with CSS were measured using standard techniques. There were no differences between the subjects with definite or probable CSS or HES with respect to age, gender, or maintenance steroid dose. Serum CCL17, IL-8, and eotaxin levels were significantly increased in eosinophilic subjects as compared to normal controls, but were similar between the eosinophilic groups. Serum CCL17 correlated with eosinophil count (P < 0.0001, r = 0.73), but not with prednisone dose. In patients with a history of asthma and sinusitis, distinguishing between ANCA-negative CSS and PDGFR-negative HES is difficult because of significant overlap in clinical presentation and biomarker profiles. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.

  11. Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome).

    Science.gov (United States)

    Mouthon, Luc; Dunogue, Bertrand; Guillevin, Loïc

    2014-01-01

    Recently, a group of experts in the field suggested to rename Churg-Strauss syndrome as eosinophilic granulomatosis with polyangiitis (EGPA). This condition, first described in 1951, is a rare small- and medium-sized-vessel vasculitis characterized by an almost constant association with asthma and eosinophilia, and, by the presence of anti-myeloperoxidase (MPO) antineutrophil cytoplasm antibodies (ANCA) in 30-38% of the patients. Vasculitis typically develops in a previously asthmatic and eosinophilic middle-aged patient. Asthma is severe, associated with eosinophilia and extrapulmonary symptoms. Most frequently EGPA involves the peripheral nerves and skin. Other organs, however, may be affected and must be screened for vasculitis, especially those associated with a poorer prognosis, such as the heart, kidney and gastrointestinal tract, as assessed by the recently revised Five-Factor Score (FFS). Recent insights, particularly concerning clinical differences associated with ANCA status, showed that EGPA patients might constitute a heterogeneous group. Thus, EGPA patients with anti-MPO ANCA suffered more, albeit not exclusively, from vasculitis symptoms, such as glomerulonephritis, mononeuritis multiplex and alveolar hemorrhage, whereas ANCA-negative patients more frequently develop heart involvement. This observation led to the hypothesis that EGPA might be divided into different clinical and pathophysiological subtypes, which could be managed better with more specifically adapted therapies. For now, EGPA treatment still relies mainly on corticosteroids and, when necessary for patients with poorer prognoses, combined immunosuppressant drugs, especially cyclophosphamide. Overall survival of EGPA patients is good, despite not uncommon relapses. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Association of proteinuria with various clinical findings and morphologic variables of oxford classification in immunoglobulin a nephropathy patients

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    Hamid Nasri

    2013-01-01

    Conclusions: Our findings firstly support the prognostic value of crescent due to its association with proteinuria and secondly imply the importance of treatment of proteinuria to prevent progression of IgAN.

  13. Electron Distribution Functions in the Diffusion Region of Asymmetric Magnetic Reconnection

    Science.gov (United States)

    Bessho, N.; Chen, L.-J.; Hesse, M.

    2016-01-01

    We study electron distribution functions in a diffusion region of antiparallel asymmetric reconnection by means of particle-in-cell simulations and analytical theory. At the electron stagnation point, the electron distribution comprises a crescent-shaped population and a core component. The crescent-shaped distribution is due to electrons coming from the magnetosheath toward the stagnation point and accelerated mainly by electric field normal to the current sheet. Only a part of magnetosheath electrons can reach the stagnation point and form the crescent-shaped distribution that has a boundary of a parabolic curve. The penetration length of magnetosheath electrons into the magnetosphere is derived. We expect that satellite observations can detect crescent-shaped electron distributions during magnetopause reconnection.

  14. 75 FR 60748 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2010-10-01

    ...-433-3200. EIS No. 20100388, Final EIS, BLM, OR, West Butte Wind Power Project, Construction and...-Highway Vehicle Project, Designated Off-Highway Vehicle (OHV) Trail System, Crescent Ranger District...

  15. Microlensing as a Possible Probe of Event-Horizon Structure in Quasars

    Energy Technology Data Exchange (ETDEWEB)

    Tomozeiu, Mihai [Zurich U.; Mohammed, Irshad [Fermilab; Rabold, Manuel [Zurich U.; Saha, Prasenjit [Zurich U.; Wambsganss, Joachim [Heidelberg U.

    2016-04-06

    In quasars which are lensed by galaxies, the point-like images sometimes show sharp and uncorrelated brightness variations (microlensing). These brightness changes are associated with the innermost region of the quasar passing through a complicated pattern of caustics produced by the stars in the lensing galaxy. In this paper, we study whether the universal properties of optical caustics could enable extraction of shape information about the central engine of quasars. We present a toy model with a crescent-shaped source crossing a fold caustic. The silhouette of a black hole over an accretion disk tends to produce roughly crescent sources. When a crescent-shaped source crosses a fold caustic, the resulting light curve is noticeably different from the case of a circular luminosity profile or Gaussian source. With good enough monitoring data, the crescent parameters, apart from one degeneracy, can be recovered.

  16. Microlensing as a possible probe of event-horizon structure in quasars

    Science.gov (United States)

    Tomozeiu, Mihai; Mohammed, Irshad; Rabold, Manuel; Saha, Prasenjit; Wambsganss, Joachim

    2018-04-01

    In quasars which are lensed by galaxies, the point-like images sometimes show sharp and uncorrelated brightness variations (microlensing). These brightness changes are associated with the innermost region of the quasar passing through a complicated pattern of caustics produced by the stars in the lensing galaxy. In this paper, we study whether the universal properties of optical caustics could enable extraction of shape information about the central engine of quasars. We present a toy model with a crescent-shaped source crossing a fold caustic. The silhouette of a black hole over an accretion disc tends to produce roughly crescent sources. When a crescent-shaped source crosses a fold caustic, the resulting light curve is noticeably different from the case of a circular luminosity profile or Gaussian source. With good enough monitoring data, the crescent parameters, apart from one degeneracy, can be recovered.

  17. Pneumonia Organizativa Fibrinosa Aguda Induzida pelo Rituximab: Uma Entidade a (Reconhecer

    Directory of Open Access Journals (Sweden)

    Alexandra Couto

    2017-10-01

    Dada a utilização crescente de terapêuticas-alvo em oncologia, o presente caso pretende contribuir para o reconhecimento desta entidade como potencial evento adverso. Recebido: 07/06/2017 - Aceite: 30/08/2017

  18. Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells.

    Science.gov (United States)

    Smeets, Bart; Uhlig, Sandra; Fuss, Astrid; Mooren, Fieke; Wetzels, Jack F M; Floege, Jürgen; Moeller, Marcus J

    2009-12-01

    Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown. In this study, we examined proliferating cells by lineage tracing of either podocytes or parietal epithelial cells (PECs) in the nephrotoxic nephritis model of inflammatory crescentic glomerulonephritis. In addition, we traced the fate of genetically labeled PECs in the Thy-1.1 transgenic mouse model of collapsing glomerulopathy. In both models, cellular bridges composed of PECs were observed between Bowman's capsule and the glomerular tuft. Genetically labeled PECs also populated larger, more advanced cellular lesions. In these lesions, we detected de novo expression of CD44 in activated PECs. In contrast, we rarely identified genetically labeled podocytes within the cellular lesions of crescentic glomerulonephritis. In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases.

  19. Le fabbricerie, esempio di intesa tra autorità civile e autorità religiosa

    Directory of Open Access Journals (Sweden)

    Paolo Moneta

    2017-11-01

    Full Text Available SOMMARIO: 1. Crescente attenzione verso le fabbricerie e il loro organo di amministrazione - 2. Una recente sentenza del TAR Toscana sul consiglio di amministrazione delle fabbricerie - 3. La posizione del vescovo diocesano nei riguardi delle fabbricerie.

  20. [Blood transfusion and advertising].

    Science.gov (United States)

    Mathez, P; Chapuis, S

    2006-09-01

    The Red-Cross and Red-Crescent International Museum has been owning from 1995 a collection (series) of 12,000 posters coming from the International Federation of the Red-Cross and Red-Crescent National Societies. These posters are dedicated to the prevention of diseases and health promotion. Blood donation is featured everywhere in this package. While the interpretation of the whole set is underway, this article presents some of these topics based on the display of some ten posters.

  1. Morphodynamics of nearshore rhythmic sandbars in a mixed-energy environment (SW France): I. Mapping beach changes using visible satellite imagery

    Science.gov (United States)

    Lafon, V.; De Melo Apoluceno, D.; Dupuis, H.; Michel, D.; Howa, H.; Froidefond, J. M.

    2004-10-01

    This paper presents a new method to analyze the morphology and migration of shallow water sandbanks based on the retrieval of maps from high-resolution Spot satellite imagery. This approach was applied to the study of intertidal ridge and runnel systems and subtidal crescents that border the southwest coast of France. Maps were obtained from 16 Spot images recorded between 1986 and 2000. Ridge and runnel shapes, with regard to a reference level, were delineated using a watercolor reflectance code parameterized and validated with field data. Crescent plan shapes, which appear on the images due to water transparency or breaking-induced foam, were directly extracted. The spatial maps show that, in conformity with field surveys, the mean alongshore spacing of intertidal systems and crescents range from 370 ± 146 m (variability is indicated by standard deviation) to 462 ± 188 m, and from 579 ± 200 to 818 ± 214 m, respectively. Several couples of images also show that ridge and runnel systems and crescents move in the longshore drift direction (southward) by about 2.4-3.1 and 1 m day -1, respectively. Alongshore migration rates of intertidal systems are confirmed by field surveys, whilst crescent dynamics cannot be validated because there is no in situ data available. To complete these measurements, an analysis of the influence of wave climate on both the shape and movements of these rhythmic sedimentary patterns is proposed in a companion paper.

  2. Clinical presentation and outcome prediction of clinical, serological, and histopathological classification schemes in ANCA-associated vasculitis with renal involvement.

    Science.gov (United States)

    Córdova-Sánchez, Bertha M; Mejía-Vilet, Juan M; Morales-Buenrostro, Luis E; Loyola-Rodríguez, Georgina; Uribe-Uribe, Norma O; Correa-Rotter, Ricardo

    2016-07-01

    Several classification schemes have been developed for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with actual debate focusing on their clinical and prognostic performance. Sixty-two patients with renal biopsy-proven AAV from a single center in Mexico City diagnosed between 2004 and 2013 were analyzed and classified under clinical (granulomatosis with polyangiitis [GPA], microscopic polyangiitis [MPA], renal limited vasculitis [RLV]), serological (proteinase 3 anti-neutrophil cytoplasmic antibodies [PR3-ANCA], myeloperoxidase anti-neutrophil cytoplasmic antibodies [MPO-ANCA], ANCA negative), and histopathological (focal, crescenteric, mixed-type, sclerosing) categories. Clinical presentation parameters were compared at baseline between classification groups, and the predictive value of different classification categories for disease and renal remission, relapse, renal, and patient survival was analyzed. Serological classification predicted relapse rate (PR3-ANCA hazard ratio for relapse 2.93, 1.20-7.17, p = 0.019). There were no differences in disease or renal remission, renal, or patient survival between clinical and serological categories. Histopathological classification predicted response to therapy, with a poorer renal remission rate for sclerosing group and those with less than 25 % normal glomeruli; in addition, it adequately delimited 24-month glomerular filtration rate (eGFR) evolution, but it did not predict renal nor patient survival. On multivariate models, renal replacement therapy (RRT) requirement (HR 8.07, CI 1.75-37.4, p = 0.008) and proteinuria (HR 1.49, CI 1.03-2.14, p = 0.034) at presentation predicted renal survival, while age (HR 1.10, CI 1.01-1.21, p = 0.041) and infective events during the induction phase (HR 4.72, 1.01-22.1, p = 0.049) negatively influenced patient survival. At present, ANCA-based serological classification may predict AAV relapses, but neither clinical nor serological

  3. [Cardiac involvement in Churg-Strauss syndrome].

    Science.gov (United States)

    Brucato, Antonio; Maestroni, Silvia; Masciocco, Gabriella; Ammirati, Enrico; Bonacina, Edgardo; Pedrotti, Patrizia

    2015-09-01

    Churg-Strauss syndrome, recently renamed eosinophilic granulomatosis with polyangiitis (EGPA), is a rare form of systemic vasculitis, characterized by disseminated necrotizing vasculitis with extravascular granulomas occurring among patients with asthma and tissue eosinophilia. EGPA is classified as a small and medium-sized vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) and the hypereosinophilic syndrome. Typical clinical features include asthma, sinusitis, transient pulmonary infiltrates and neuropathy. Blood eosinophils are often >1500/µl or more than 10% on the differential leukocyte count. Blood eosinophils should always be tested in unexplained cardiac disorders, and may normalize even after low doses of corticosteroids. ANCA are positive in 40-60% of cases, mainly anti-myeloperoxidase. Heart involvement occurs in approximately 15-60% of EGPA patients, especially those who are ANCA negative. Any cardiac structure can be involved, and patients present with myocarditis, heart failure, pericarditis, arrhythmia, coronary arteritis, valvulopathy, intracavitary cardiac thrombosis. Although cardiovascular involvement is usually an early manifestation, it can also occur later in the course of the disease. A significant proportion of patients with cardiac involvement is asymptomatic. In the absence of symptoms and major ECG abnormalities, cardiac involvement may be detected in nearly 40% of the patients. All patients with EGPA should be studied not only with a detailed history of cardiac symptoms and ECG, but also with echocardiography; if abnormalities are detected, a cardiac magnetic resonance study should be performed. Coronary angiography and endomyocardial biopsy should be reserved to selected cases. Heart involvement carries a poor prognosis and causes 50% of the deaths of these patients. It is often insidious and underestimated. Optimal therapy is therefore important and based on high-dose corticosteroids plus immunosuppressive

  4. Suggestion of a conventional Islamic calendar

    Directory of Open Access Journals (Sweden)

    M.G. Rashed

    2017-12-01

    Full Text Available There is a complexity of the problem concerning the first sighting of the new lunar crescent, which is attributed to various astronomical, astrophysical and geographical factors. Therefore, Astronomers adopted various criteria for the new crescent visibility. Muslims around the world differ in the beginning of the Hijric months. In fact the differences are not due to different methodology of astronomical calculations, which in turn the variations of the calendar at different countries gives. Farewell Hajj of Prophet Mohamed was on Friday, the ninth of Thul'hejja of the tenth year of immigration (Biography of the Prophet Mohamed. Therefor; the beginning of the month of Thul'hejja 10 A.H is on Thursday. Our suggested calendar takes Farewell Hajj of the Prophet Mohammad to be the base of this calendar. The advantage of our suggested calendar far away from any criteria; where the adoption of criteria for the new crescent visibility is often misleading.

  5. Suggestion of a conventional Islamic calendar

    Science.gov (United States)

    Rashed, M. G.; Moklof, M. G.

    2017-12-01

    There is a complexity of the problem concerning the first sighting of the new lunar crescent, which is attributed to various astronomical, astrophysical and geographical factors. Therefore, Astronomers adopted various criteria for the new crescent visibility. Muslims around the world differ in the beginning of the Hijric months. In fact the differences are not due to different methodology of astronomical calculations, which in turn the variations of the calendar at different countries gives. Farewell Hajj of Prophet Mohamed was on Friday, the ninth of Thul'hejja of the tenth year of immigration (Biography of the Prophet Mohamed). Therefor; the beginning of the month of Thul'hejja 10 A.H is on Thursday. Our suggested calendar takes Farewell Hajj of the Prophet Mohammad to be the base of this calendar. The advantage of our suggested calendar far away from any criteria; where the adoption of criteria for the new crescent visibility is often misleading.

  6. Óleos essenciais e fitoconstituintes: citotoxidade e potencial antibacteriano in vitro e em matriz alimentar de base láctea

    OpenAIRE

    Gabrielle Ferreira da Silva, Márcia

    2011-01-01

    A conservação de alimentos é um constante desafio da indústria alimentícia, visto que, novos produtos surgem constantemente no mercado. Além disso, a crescente busca dos consumidores por alimentos mais saudáveis tem estimulado pesquisas a respeito de substâncias naturais que possam substituir conservantes químicos. É crescente o número de estudos investigando a atividade antimicrobiana de óleos essenciais e de seus componentes, assim como a inocuidade de sua utilização na conse...

  7. Avaliação Económica de um Sistema de Produção Fotovoltaico para Autoconsumo

    OpenAIRE

    Ana Lúcia Costa Gomes; António Pedro Soares Pinto; Joana Rita Silva Fialho

    2018-01-01

    A escassez de recursos naturais, o aumento de necessidades energéticas, os incentivos recentes em termos legislativos e uma preocupação crescente com as questões ambientais, desencadearam uma procura crescente de fontes alternativas de energia. Este estudo pretende analisar a viabilidade económica de um sistema fotovoltaico (FV) de produção de eletricidade para autoconsumo, no Campus Politécnico de Viseu. A avaliação foi efetuada, tendo por base a criação de 3 cenários para a potência de liga...

  8. Remoção dos interferentes endócrinos 17 'alfa'-etinilestradiol, 17 'beta'-estradiol e 4-nonilfenol por adsorção em carvão ativado em pó em água de abastecimento público

    OpenAIRE

    Mariana Rodrigues Peres

    2011-01-01

    Resumo: Nas últimas décadas, verifica-se um crescente interesse científico a respeito dos potenciais adversos associados à exposição humana e animal aos interferentes endócrinos. A ocorrência de interferentes endócrinos em efluente de Estação de Tratamento de Esgoto (ETE) e em águas superficiais constitui um crescente interesse científico devido à probabilidade de que esses micropoluentes não sejam removidos nos processos físico-químicos empregados em Estação de Tratamento de Água (ETA) conve...

  9. O impacto do uso e consumo de água na mineração sobre o bloco de energia assegurada em empreendimentos hidrogeradores: estudo de caso da PCH Bicas

    OpenAIRE

    Sergio Pinheiro de Freitas

    2012-01-01

    A crescente demanda por produtos minerais no mercado internacional é responsável por um considerável aumento das atividades mineradoras no Brasil. Paralelamente a isso se tem notado uma crescente demanda de energia elétrica pela sociedade brasileira. Dentro desse contexto, emergem atividades concorrentes e que se esbarram e causam interferências cruzadas entre empreendimentos. Tem-se então uma situação de conflito, uma vez que outorgas de uso de água para atividades mineradoras impactam, entr...

  10. Flags of the night sky when astronomy meets national pride

    CERN Document Server

    Bordeleau, André G

    2014-01-01

    Many national flags display astronomical features–Sun, Moon, stars–but are they really based on existing astronomical objects? The United States flag sports 50 stars, one for each state, however none of them are linked to real stars. Further, the lunar crescent is often shaped like the Sun being eclipsed by the Moon. At times, stars are seen right next to the crescent, where the darkened disc of the moon should be! This book will present true astronomical objects and patterns highlighted on national flags and link informative capsules about these objects to the political reasons why they were chosen to adorn such an important symbol.

  11. Perfil das pacientes submetidas a gluteoplastia

    OpenAIRE

    José Horácio Costa Aboudib Júnior

    2014-01-01

    Durante nossas frequentes apresentações em cursos, congressos e jornadas e mesmo em nossas publicações, existiam constantes perguntas sobre o perfil dessas pacientes. O crescente interesse da mídia e das pacientes a este respeito e também a crescente procura pela cirurgia nos estimulou a realizar este trabalho. Segundo dados da Sociedade Brasileira de Cirurgia Plástica (SBPC) e da American Society of Plastic Surgery (ASPS), referem que 20.000 pacientes foram submetidas a esta cirurgia. Em 201...

  12. Process mining : come estrarre conoscenza dai log dei sistemi informativi orientati ai processi

    NARCIS (Netherlands)

    Aalst, van der W.M.P.; Burattin, A.; Leoni, de M.; Guzzo, A.; Maggi, F.M.; Montali, M.

    2012-01-01

    Le tecniche di Process Mining consentono di modellare, monitorare e migliorare i processi in un'ampia varietà di domini applicativi. Queste tecniche sono oggetto di crescente interesse per la necessità di adeguare i processi di business a contesti sempre più competitivi e in rapida evoluzione.

  13. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 100 of 247 ... Vol 29, No 1 (2016), Insights from Hans Achterhuis Applied to the Violence on LGBT Communities in Uganda, Abstract. Jaco Beyers. Vol 28, No 1 (2015), Interpreting Luguru Religious Practice through Colonialist Eyes: Child Sacrifice and East African Dance in Brett Young's The Crescent Moon ...

  14. Obesity : a growing problem

    NARCIS (Netherlands)

    Seidell, J C

    Obesity, defined as a body mass index (BMI) of 30 kg/m2 or more, is common in many parts of the world, especially in the established market economies, the former socialist economies of Europe, Latin America, the Caribbean and the Middle Eastern Crescent. As many as 250 million people worldwide may

  15. Three Capitals for Two States -- Analysis of Jerusalem’s Sovereignty and Perspectives

    Science.gov (United States)

    2011-05-19

    central plot in each of them when he described Jerusalem as “a Dome, A Tomb and a 7 Wall; a Crescent, a Cross and a Star; three faiths, three...day Israel, Lebanon, Jordan and parts of Syria, was at the crossroads of the Persian, Egyptian , and Assyrian empires, and Jerusalem was on the central

  16. HOW to Identify and Control Sapsucker Injury on Trees

    Science.gov (United States)

    Michael E. Ostry; Thomas H. Nicholls

    1976-01-01

    The yellow-bellied sapsucker (Sphyrapicus varius), a member of the woodpecker family, is a migratory bird whose summer breeding range includes the Lakes States region. The identifying field markings of adult birds are a black crescent on the breast, pale yellow belly, white wing stripe, and a crimson crown. The male also has a crimson chin and throat, distinguishing...

  17. Eastern Arc Mountains and their national and global importance ...

    African Journals Online (AJOL)

    The Eastern Arc Mountains comprise a chain of separate mountain blocks running from southern Kenya through Tanzania in a crescent or arc shape. In Tanzania, the Eastern Arc consists of North and South Pare, East and West Usambaras, Nguru, Ukaguru, Rubeho, Uluguru, Udzungwa and Mahenge Mountains.

  18. Untitled

    Indian Academy of Sciences (India)

    A major portion of the epidermis is occupied by numerous long saccular mucous cells with crescentic nuclei. Taste-buds are profusely present near thc apex of the lip, each being borne on an elevation of the dermis. The dermis consists of a rather loose connective-tissue in its outer part and a compact one inside and bears ...

  19. Presumed drowning of Aleutian Canada geese on the Pacific coast of California and Oregon

    Science.gov (United States)

    Springer, Paul F.; Lowe, Roy W.; Stroud, Richard K.; Gullett, Patricia A.

    1989-01-01

    Carcasses of 42 and 17 Aleutian Canada geese (Branta canadensis leucopareia), a federally listed endangered species, were found on ocean beaches near Crescent City, California, and near Pacific City, Oregon, respectively, following severe storms. Necropsies and other information suggest that the birds were flushed during the storms and somehow entered the water where they were washed into the surf and drowned.

  20. ANCA-GBM dot-blot : Evaluation of an assay in the differential diagnosis of patients presenting with rapidly progressive glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Damoiseaux, Jan; Roozendaal, Caroline; Limburg, Pieter C; Stegeman, Coen A; Tervaert, Jan Willem Cohen

    Rapidly progressive glomerulonephritis (RPGN) is characterized by rapid and progressive loss of renal function and the presence of crescentic glomerulonephritis (CGN). Early diagnosis and appropriate treatment is mandatory to prevent death and/or renal failure. We have evaluated an ANCA-GBM dot-blot

  1. Detainee Medical Operations during Operation Iraqi Freedom: Determination of a Transition Plan

    Science.gov (United States)

    2007-06-15

    Additionally, a panel of physicians should provide consensual guidelines on resuscitative procedures and euthanasia . These topics do not have clear cut...International Federation of Red Cross and Red Crescent Societies (IFRC) or another voluntary aid organization which is recognized and authorized by its

  2. ORF Alignment: NC_002696 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_002696 gi|16126641 >1uzbA 58 515 12 462 8e-77 ... ref|NP_421205.1| vanillin dehydr...ogenase [Caulobacter crescentus CB15] gb|AAK24373.1| ... vanillin dehydrogenase [Caulobacter crescent...us CB15] ... pir||A87547 vanillin dehydrogenase [imported] - ... Caulobacter crescentus ...

  3. Para além do desrespeitos e do abuso

    DEFF Research Database (Denmark)

    Sadler, Michelle; Mario, Santos; Ruiz Buron, Dolores

    2017-01-01

    Durante décadas, tem sido relatado o crescente e preocupante excesso de intervenções médicas durante o parto, mesmo em partos fsiológicos e sem complicações, juntamente com um aumento preocupante de práticas abusivas e desrespeitosas contra mulheres durante o parto em todo o mundo. Apesar das pes...

  4. Investigations of surface characterization of silicone rubber due to ...

    Indian Academy of Sciences (India)

    Unknown

    †Department of Polymer Technology, Crescent Engineering College, Chennai 600 048, India. Abstract. In the present work, tracking ... Silicone rubber; surface degradation; tracking; WAXD; TG–DTA. 1. Introduction. Power transmission at ... mena in polymer insulators under d.c. voltages. Hence the tracking phenomena ...

  5. Multiple post-domestication origins of kabuli chickpea through allelic variation in a diversification-associated transcription factor

    Science.gov (United States)

    Chickpea (Cicer arietieum) is a widely cultivated food legume and one of the Neolitic founder crops domesticated in the Fertile Crescent. Cultivated chickpea is classified into two types, a ‘desi’ type with smaller and darker seed coats, and a light-colored large-seeded ‘kabuli’ type, with the two t...

  6. Reversal of progressive necrotizing vasculitis with intravenous pulse cyclophosphamide and methylprednisolone.

    Science.gov (United States)

    Fort, J G; Abruzzo, J L

    1988-09-01

    We describe a patient with polyarteritis nodosa who, despite therapy with daily doses of oral prednisone and cyclophosphamide, developed acute renal failure. Renal histopathologic examination demonstrated crescentic glomerulonephritis. Treatment with intravenous pulse cyclophosphamide and methylprednisolone resulted in clinical improvement and significant recovery of renal function.

  7. Untitled

    Indian Academy of Sciences (India)

    Conklin, 1905). The entrance of the sperm into the egg is marked by movement of the ooplasmic contents. Three zones, viz., the clear cyto- plasmic region, the grey yolky region and the crescent of lipoidal inclusions can be made out (Fig. 1).

  8. The Mitogen-Activated Protein Kinase p38 alpha Regulates Tubular Damage in Murine Anti-Glomerular Basement Membrane Nephritis

    NARCIS (Netherlands)

    Mueller, Ralf; Daniel, Christoph; Hugo, Christian; Amann, Kerstin; Mielenz, Dirk; Endlich, Karlhans; Braun, Tobias; van der Veen, Betty; Heeringa, Peter; Schett, Georg; Zwerina, Jochen

    2013-01-01

    p38 mitogen-activated protein kinase (MAPK) is thought to play a central role in acute and chronic inflammatory responses. Whether p38MAPK plays a pathogenic role in crescentic GN (GN) and which of its four isoforms is preferentially involved in kidney inflammation is not definitely known. We thus

  9. Urethral advancement procedure in the treatment of primary distal ...

    African Journals Online (AJOL)

    advancement in the repair of primary distal penile hypospadias with regard to feasibility, complication rates .... stones and growth, and any associated congenital anomaly. Meticulous local examination was performed ... with a tourniquet placed on the root of the penis. A submeatal crescent-like incision was performed a few.

  10. Bathymetric study of the Neotectonic Naini Lake in outer Kumaun Himalaya

    Digital Repository Service at National Institute of Oceanography (India)

    Hashimi, N.H.; Pathak, M.C; Jauhari, P.; Nair, R.R.; Sharma, A.K.; Bhakuni, D.S.; Bisht, M.K.S.; Valdiya, K.S.

    The Naini Lake is a product of rotational movement on a NW-SE trending Nainital Fault, quite after the establishment of the drainage of a mature stream named Balia Nala. Detailed bathymetric study, permits division of this crescent-shaped lake...

  11. Solution of the Cubic

    Indian Academy of Sciences (India)

    Foundation of Basic Arith- metic, Resonance, Vol.l1, No.1 ... duced, in his book The Analytic Art, our present usage of letters to ... symbols for surplus and deficit in business records. In. 1514, the Dutch ..... Email:jasbir@math.byu.edu ... crescent ...

  12. Okinawan Subtropical Plants as a Promising Resource for Novel Chemical Treasury.

    Science.gov (United States)

    Matsunami, Katsuyoshi; Otsuka, Hideaki

    2018-01-01

    The Okinawa Islands are a crescent-shaped archipelago and their natural forests hold a huge variety of unique subtropical plants with relatively high endemism. We have performed phytochemical study on Okinawan subtropical plants for many years. In this review, we describe our recent research progress on the isolation of new compounds and their various bioactivities.

  13. Wild emmer genome architecture and diversity elucidate wheat evolution and domestication

    Science.gov (United States)

    Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent over 10,000 years ago. Identifying genetic modifications underlying wheat's domestication requires knowledge of the genome of its allo-tetraploid proge...

  14. Near field imaging of transient collisional excitation x-ray laser

    International Nuclear Information System (INIS)

    Tanaka, Momoko; Kado, Masataka; Hasegawa, Noboru; Kawachi, Tetsuya; Sukegawa, Kouta; Lu, Peixiang; Nagashima, Akira; Kato, Yoshiaki

    2001-01-01

    We observed the spatial profile of the transient collisional excitation Ni-like Ag laser (λ=13.9 nm) for various plasma lengths using the near field imaging method. The gain coefficient of the x-ray laser was estimated as 24 cm -1 . The gain region was a 50 μm crescent shape and included localized high gain areas. (author)

  15. 77 FR 59193 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-09-26

    ... Type: New OFF License. Bring Logistics US, Inc. (NVO & OFF), 4500 N. Sam Houston Parkway W., 130...: New NVO & OFF License. Contract Logistics, LLC (NVO & OFF), 4911 N. Portland Avenue, Suite 200.... Roush, Manager, Application Type: New NVO & OFF License. Crescent Line Inc. dba Globe Express Services...

  16. Genetic diversity in barley landraces (Hordeum vulgare L. subsp.

    Indian Academy of Sciences (India)

    Genetic diversity in barley landraces (Hordeum vulgare L. subsp. vulgare) originated from Crescent Fertile region as detected by seed storage proteins. RIM MZID FARHAT CHIBANI RAYDA BEN AYED MOHSEN HANANA JOELLE BREIDI RABIH KABALAN SAMIH EL-HAJJ HASSAN MACHLAB AHMED REBAI LAMIS ...

  17. Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells.

    NARCIS (Netherlands)

    Smeets, B.; Uhlig, S.; Fuss, A.; Mooren, F.; Wetzels, J.F.M.; Floege, J.; Moeller, M.J.

    2009-01-01

    Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown. In this study, we examined proliferating cells by lineage tracing of either podocytes or parietal

  18. 78 FR 7427 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2013-02-01

    ... Waters Canoe Area Wilderness (BWCAW) Non-native Plant Management Project, Cook, Lake and St. Louis... EIS, AFS, OR, Rim Paunina Project and Forest Plan Amendments, Crescent Ranger District, Deschutes... Development Project, Approval of Gaming Development and Management, Spokane County, WA, Review Period Ends: 03...

  19. 75 FR 70917 - Environmental Impacts Statements; Notice Of Availability

    Science.gov (United States)

    2010-11-19

    ... the Federal Register. EIS No. 20100444, Final EIS, BLM, NV, Tonopah Solar Energy Crescent Dunes Solar Energy Project, a 7,680-Acre Right-of-Way (ROW) on Public Lands to Construct a Concentrated Solar Thermal... Restart an Idled Production Line and Expand Contiguous Sections of the Open Pit Iron Ore Mine, located...

  20. Interaction among the electric power concessionaire, the private sector and the customers; Interacao concessionaria de energia eletrica, iniciativa privada e clientes

    Energy Technology Data Exchange (ETDEWEB)

    Silva Pontes, Valdenir da; Mendonca, Antonio Carlos de; Pennachiotti, Carlos Cesar [Companhia Paulista de Forca e Luz (CPFL), Campinas, SP (Brazil)

    1992-12-31

    This present work shows a franchising plan for the consumer sector services: reading of the electric energy measuring equipment and bill delivering. In order to reduce the operational costs of the electric energy enterprises and the payment sheet, this plan will leads to optimize the crescent demand services. 1 tab., 2 refs.

  1. Identification of RNA binding motif proteins essential for cardiovascular development

    NARCIS (Netherlands)

    S. Maragh (Samantha); R.A. Miller (Ronald); S.L. Bessling (Seneca); D.M. McGaughey (David); M.W. Wessels (Marja); B.M. de Graaf (Bianca); E.A. Stone (Eric); A.M. Bertoli Avella (Aida); J.D. Gearhart (John); S. Fisher (Shannon); A.S. McCallion (Andrew)

    2011-01-01

    textabstractBackground: We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming vasculature we posited it to be a key player in cardiogenesis

  2. Manifesto de ciência social computacional

    NARCIS (Netherlands)

    Conte, R.; Gilbert, N.; Bonelli, G.; Cioffi-Revilla, C.; Deffuant, G.; Kertesz, J.; Loreto, V.; Moat, S.; Nadal, J. -P.; Sanchez, A.; Nowak, A; Flache, Andreas; San Miguel, M.; Helbing, D.

    2013-01-01

    A crescente integração da tecnologia em nossas vidas criou volumes sem precedentes de dados sobre o comportamento cotidiano da sociedade. Esses dados abrem novas oportunidades para se trabalhar em direção a um entendimento quantitativo dos sistemas sociais complexos, no âmbito de uma nova disciplina

  3. Characterisation of submerged arc welding process using infrared imaging technique

    CSIR Research Space (South Africa)

    Zondi, MC

    2017-09-01

    Full Text Available function of material emissivity, which in turn is affected by the surface condition of the material. a. UKZN PhD Eng. Student, 7 Cordia Crescent, Umhlanga Rocks, Durban, 4043, zondi@outlook.com b. CSIR DPSS, Landward Sciences, yanga...

  4. Understanding coastal morphodynamic patterns from depth-averaged sediment concentration

    NARCIS (Netherlands)

    Ribas, F.; Falques, A.; de Swart, H. E.; Dodd, N.; Garnier, R.; Calvete, D.

    This review highlights the important role of the depth-averaged sediment concentration (DASC) to understand the formation of a number of coastal morphodynamic features that have an alongshore rhythmic pattern: beach cusps, surf zone transverse and crescentic bars, and shoreface-connected sand

  5. Radon in mining exploration of the deposits of the Shaba Copperbelt (Republique du Congo, Africa)

    International Nuclear Information System (INIS)

    Charlet, J.M.; Makabu, K.

    1999-01-01

    Radon in soils has been tested for the exploration of copper-cobalt deposits of the Shaba crescent where uranium is often a pathfinder element. A very simple technique has been developed using a charcoal detector and a reading by a portable scintillator

  6. The uses of continuous thermodynamics in the perfluoropolieter production

    International Nuclear Information System (INIS)

    Silva, Eduardo Ramos Ferreira da; Terron, Luiz Roberto

    1995-01-01

    The use of continuous thermodynamics technic is crescent in the resolution of problems found in the chemical engineering process, involving complex mixtures. This new technic substitute, with advantages (larger precision and less CPU time) the traditional method (pseudo components method) and can can also be used in nuclear technology, when problems involving complexes mixtures are presented. (author). 37 refs

  7. Ex-Ante Impact Assessment of Water Policy Reform in South-Eastern Tunisia: A CGE Approach

    NARCIS (Netherlands)

    Abdelahim, M.A.; Chant, L.J.; Abdallah, A.; Sghaier, M.

    2011-01-01

    Localizada no sudeste da Tunísia, o território Medenine é caracterizado por um clima árido. A escassez de água foi acentuada pela crescente demanda de diferentes setores econômicos. A competição inter-setorial pela água, principalmente entre o turismo e a agricultura, representa um grande problema.

  8. Spacecraft radiator systems

    Science.gov (United States)

    Anderson, Grant A. (Inventor)

    2012-01-01

    A spacecraft radiator system designed to provide structural support to the spacecraft. Structural support is provided by the geometric "crescent" form of the panels of the spacecraft radiator. This integration of radiator and structural support provides spacecraft with a semi-monocoque design.

  9. Trigeminalt trofisk syndrom--

    DEFF Research Database (Denmark)

    Kjaerskov, Mette Wanscher; Bygum, Anette

    2009-01-01

    Trigeminal trophic syndrome (TTS) is a rare but well-described syndrome consisting of the triad: paraesthesia, anaesthesia and crescent-shaped ulceration of the ala nasi. We report a case of a 62-year-old woman presenting with TTS after operative excision of an acusticus neurinoma. She attended s...

  10. RENAL ISCHEMIA-REPERFUSION INJURY CONTRIBUTES TO RENAL DAMAGE IN EXPERIMENTAL ANTI-MYELOPEROXIDASE-ASSOCIATED PROLIFERATIVE GLOMERULONEPHRITIS

    NARCIS (Netherlands)

    BROUWER, E.; Klok, P.A; HUITEMA, M.G.; Weening, J.J.; Kallenberg, Cees

    The occurrence of focal fibrinoid necrosis of capillary loops in the very early stages of ANCA-associated necrotizing crescentic glomerulonephritis (NCGN) and the increased prevalence of this disease at older age suggest that renal ischemia may play an additional role in its pathophysiology. In the

  11. Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model

    NARCIS (Netherlands)

    Brouwer, E.; Huitema, M. G.; Klok, P. A.; de Weerd, H.; Tervaert, J. W.; Weening, J. J.; Kallenberg, C. G.

    1993-01-01

    To develop an animal model for antimyeloperoxidase (MPO)-associated necrotizing crescentic glomerulonephritis (NCGN), we immunized Brown Norway rats with MPO and localized a neutrophil lysosomal enzyme extract, primarily consisting of MPO and elastinolytic enzymes, plus H2O2, the substrate of MPO,

  12. ANTIMYELOPEROXIDASE-ASSOCIATED PROLIFERATIVE GLOMERULONEPHRITIS - AN ANIMAL-MODEL

    NARCIS (Netherlands)

    BROUWER, E; HUITEMA, MG; KLOK, PA; DEWEERD, H; TERVAERT, JWC; WEENING, JJ; KALLENBERG, CGM

    1993-01-01

    To develop an animal model for antimyeloperoxidase (MPO)-associated necrotizing crescentic glomerulonephritis (NCGN), we immunized Brown Norway rats with MPO and localized a neutrophil lysosomal enzyme extract, primarily consisting of MPO and elastinolytic enzymes, plus H2O2, the substrate of MPO,

  13. Andare a consumare

    Directory of Open Access Journals (Sweden)

    Andreas Fernandez

    2009-03-01

    Non si sorprende più nessuno quando si afferma che il rilievo crescente rivestito dalla cultura e dalle pratiche di consumo nella nostra vita di tutti i giorni, nelle relazioni interpersonali che ci coinvolgono e, ovviamente, nell’universo economico, ha reso la produzione sempre meno nucleo di interesse delle scienze sociali.

  14. A food plant specialist in Sparganothini? A new genus and species from Costa Rica (Lepidoptera: Tortricidae)

    Science.gov (United States)

    Sparganocosma docsturnerorum Brown, new genus and new species, is described and illustrated from Area de Conservación (ACG) in northwestern Costa Rica. The new genus shares a long, crescent- or ribbon-shaped signum in the corpus bursae of the female genitalia with Aesiocopa Zeller, 1877, Amorbia Cle...

  15. Fed Up with Rising Premiums, Colleges Go into the Insurance Business

    Science.gov (United States)

    June, Audrey William

    2006-01-01

    American universities are turning to captive companies, a highly specialized form of self-insurance, in an effort to cope with ever-increasing premiums. Indiana University formed the Old Crescent Insurance Company in 2005 to provide coverage for the institution's eight campuses, a move that gives it more control over costs while allowing the…

  16. Dust-trapping Vortices and a Potentially Planet-triggered Spiral Wake in the Pre-transitional Disk of V1247 Orionis

    Energy Technology Data Exchange (ETDEWEB)

    Kraus, Stefan; Kreplin, Alexander; Young, Alison K.; Bate, Matthew R.; Harries, Tim T.; Willson, Matthew [University of Exeter, School of Physics, Astrophysics Group, Stocker Road, Exeter EX4 4QL (United Kingdom); Fukugawa, Misato [Division of Particle and Astrophysical Science, Graduate School of Science, Nagoya University, Nagoya (Japan); Muto, Takayuki [Division of Liberal Arts, Kogakuin University, 1-24-2 Nishi-Shinjuku, Shinjuku-ku, Tokyo 163-8677 (Japan); Sitko, Michael L. [Department of Physics, University of Cincinnati, Cincinnati, OH 45221 (United States); Grady, Carol [Eureka Scientific, 2452 Delmer Street, Suite 100, Oakland, CA 96402 (United States); Monnier, John D. [Department of Astronomy, University of Michigan, 311 West Hall, 1085 South University Avenue, Ann Arbor, MI 48109 (United States); Wisniewski, John, E-mail: skraus@astro.ex.ac.uk [Homer L. Dodge Department of Physics, University of Oklahoma, Norman, OK 73071 (United States)

    2017-10-10

    The radial drift problem constitutes one of the most fundamental problems in planet formation theory, as it predicts particles to drift into the star before they are able to grow to planetesimal size. Dust-trapping vortices have been proposed as a possible solution to this problem, as they might be able to trap particles over millions of years, allowing them to grow beyond the radial drift barrier. Here, we present ALMA 0.″04 resolution imaging of the pre-transitional disk of V1247 Orionis that reveals an asymmetric ring as well as a sharply confined crescent structure, resembling morphologies seen in theoretical models of vortex formation. The asymmetric ring (at 0.″17 = 54 au separation from the star) and the crescent (at 0.″38 = 120 au) seem smoothly connected through a one-armed spiral-arm structure that has been found previously in scattered light. We propose a physical scenario with a planet orbiting at ∼0.″3 ≈ 100 au, where the one-armed spiral arm detected in polarized light traces the accretion stream feeding the protoplanet. The dynamical influence of the planet clears the gap between the ring and the crescent and triggers two vortices that trap millimeter-sized particles, namely, the crescent and the bright asymmetry seen in the ring. We conducted dedicated hydrodynamics simulations of a disk with an embedded planet, which results in similar spiral-arm morphologies as seen in our scattered-light images. At the position of the spiral wake and the crescent we also observe {sup 12}CO(3-2) and H{sup 12}CO{sup +} (4-3) excess line emission, likely tracing the increased scale-height in these disk regions.

  17. Dust-trapping Vortices and a Potentially Planet-triggered Spiral Wake in the Pre-transitional Disk of V1247 Orionis

    Science.gov (United States)

    Kraus, Stefan; Kreplin, Alexander; Fukugawa, Misato; Muto, Takayuki; Sitko, Michael L.; Young, Alison K.; Bate, Matthew R.; Grady, Carol; Harries, Tim T.; Monnier, John D.; Willson, Matthew; Wisniewski, John

    2017-10-01

    The radial drift problem constitutes one of the most fundamental problems in planet formation theory, as it predicts particles to drift into the star before they are able to grow to planetesimal size. Dust-trapping vortices have been proposed as a possible solution to this problem, as they might be able to trap particles over millions of years, allowing them to grow beyond the radial drift barrier. Here, we present ALMA 0.″04 resolution imaging of the pre-transitional disk of V1247 Orionis that reveals an asymmetric ring as well as a sharply confined crescent structure, resembling morphologies seen in theoretical models of vortex formation. The asymmetric ring (at 0.″17 = 54 au separation from the star) and the crescent (at 0.″38 = 120 au) seem smoothly connected through a one-armed spiral-arm structure that has been found previously in scattered light. We propose a physical scenario with a planet orbiting at ˜0.″3 ≈ 100 au, where the one-armed spiral arm detected in polarized light traces the accretion stream feeding the protoplanet. The dynamical influence of the planet clears the gap between the ring and the crescent and triggers two vortices that trap millimeter-sized particles, namely, the crescent and the bright asymmetry seen in the ring. We conducted dedicated hydrodynamics simulations of a disk with an embedded planet, which results in similar spiral-arm morphologies as seen in our scattered-light images. At the position of the spiral wake and the crescent we also observe 12CO(3-2) and H12CO+ (4-3) excess line emission, likely tracing the increased scale-height in these disk regions.

  18. Olen, Helaine (2012), Pound Foolish: Exposing the Dark Side of the Personal Finance Industry

    OpenAIRE

    Costa, Vânia

    2014-01-01

    Nas últimas décadas, temos vindo a assistir a transformações socioeconómicas profundas que têm conduzido a uma crescente participação das famílias nos mercados financeiros. Com maior expressão nas economias capitalistas mais desenvolvidas, como os Estados Unidos da América e o Reino Unido, observa‑se um crescente papel do setor financeiro na mediação da provisão pública, em resultado da gradual retirada do Estado das suas funções sociais, forçando as famílias a recorrer a este setor para aced...

  19. Olen, Helaine (2012, Pound Foolish: Exposing the Dark Side of the Personal Finance Industry

    Directory of Open Access Journals (Sweden)

    Vânia Costa

    2014-02-01

    Full Text Available Nas últimas décadas, temos vindo a assistir a transformações socioeconómicas profundas que têm conduzido a uma crescente participação das famílias nos mercados financeiros. Com maior expressão nas economias capitalistas mais desenvolvidas, como os Estados Unidos da América e o Reino Unido, observa‑se um crescente papel do setor financeiro na mediação da provisão pública, em resultado da gradual retirada do Estado das suas funções sociais, forçando as famílias a recorrer a este setor para aced...

  20. Violência contra o idoso no estado de Minas Gerais: análise das notificações em 2009-2012.

    OpenAIRE

    Rezende, Mariana Marquez de

    2013-01-01

    Nos últimos quarenta anos, a população idosa foi a que mais cresceu no Brasil. Pelas suas características de maior fragilidade e vulnerabilidade fisiológica, o idoso se torna vítima em potencial para a violência crescente do dia a dia. A crescente busca por dados sobre a violência contra idosos aparece como ação promissora de transformação de políticas públicas voltadas ao tema e de abertura para o diálogo entre as esferas governamentais e sociedade visando amenizar esta situação. Para um ade...

  1. A gestão e produção de conteúdo digitais na comunicação estratégica

    OpenAIRE

    Barroso, Patrícia Afonso

    2014-01-01

    Relatório de estágio de mestrado em Ciências da Comunicação (área de especialização em Relações Públicas e Publicidade) Num contexto atual onde as novas tecnologias de informação são cada vez mais fortes, a comunicação das empresas sofreu uma alteração crescente com a transformação do panorama social e vice-versa. A evolução do mundo web e das novas formas de comunicação digital (computador, smartphone, entre outros) detiveram uma importância crescente no aparecimento de novos ...

  2. Consumo di suolo e degrado del territorio: il caso milanese

    Directory of Open Access Journals (Sweden)

    Francesco Vescovi

    2013-02-01

    Full Text Available La crescente scarsità di risorse pubbliche ha portato molti comuni italiani, complice una crescente cultura derogatoria nell’ambito della pianificazione, a diventare corresponsabili del degrado del paesaggio, alimentando artificiosamente il tasso di urbanizzazione del suolo. Mentre è evidente l’assoluta insostenibilità di un modello di “sviluppo” affidato ai meccanismi della speculazione immobiliare emerge chiaramente l’urgenza di una pianificazione strategica di scala intercomunale o metropolitana che sappia ottimizzare le sempre più scarse opportunità di rigenerazione di un territorio gravemente compromesso. I dati disponibili per il contesto milanese offrono la possibilità di indagare il fenomeno in maggior dettaglio.

  3. Uma particularidade italiana? Psicanálise, modernização e sociologia do consumo na Itália dos anos 1960

    Directory of Open Access Journals (Sweden)

    Mauro Pasqualini

    Full Text Available Resumo Durante os anos 1960, a psicanálise experimentou uma expansão notável na Itália. Um dos cenários da crescente difusão de teorias psicanalíticas foi o mundo de marketing e sociologia do consumo. Com base no caso do sociólogo Francesco Alberoni, podemos examinar o impacto das teorias de Melanie Klein para entender o comportamento dos consumidores. Da mesma forma, o “caso Alberoni” serve para observar as preocupações e incertezas sobre a modernização social na Itália e também para perguntar sobre as especificidades da crescente importância da psicanálise na Itália na década de 1960.

  4. Diabetes tipo II e resolvinas D1

    OpenAIRE

    Silva, Isabel Alexandra Marques Batista da

    2015-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz A diabetes é um problema de saúde pública crescente com o envelhecimento da população, os maus hábitos alimentares e o sedentarismo. A obesidade poderá ser causa ou consequência da diabetes tipo II, sendo também um problema crescente de saúde pública. Esta monografia tem como objetivo estudar, com base no conhecimento atual, se as resolvinas D1 são uma alternativa viável na terapêutica da diab...

  5. Produção, caracterização bioquímica e aplicação de L-asparaginase fúngica

    OpenAIRE

    Fernanda Furlan Gonçalves Dias

    2016-01-01

    Resumo: L-Asparaginases são enzimas que catalisam a hidrólise da L-asparagina a ácido L-aspártico e amônia. As L-asparaginases microbianas têm recebido atenção devido ao seu papel no tratamento da leucemia linfoblástica aguda e devido à sua crescente aplicação na indústria de alimentos visando à redução da formação de acrilamida durante o processamento de alimentos. Um número crescente de pesquisas tem estudado a aplicação dessa enzima em diferentes matrizes alimentares comprovando seus efeit...

  6. Enterocolic lymphocytic phlebitis: statistical analysis of histology features in viable and ischemic bowel.

    Science.gov (United States)

    Medlicott, Shaun A C; Guggisberg, Kelly A; DesCôteaux, Jean-Gaston; Beck, Paul

    2006-07-01

    Enterocolic lymphocytic phlebitis is a rare cause of segmental ischemic enterocolitis. This artery-sparing transmural vasculitis is classically a circumferential phlebitis with perivenular lymphocyte cuffing and thrombi in the absence of systemic manifestations. Myointimal hyperplasia may represent a chronic phase of enterocolic lymphocytic phlebitis. Subclinical or early stage enterocolic lymphocytic phlebitis is not well delineated. We analyzed 600 submucosal and subserosal veins from both ischemic and intact bowel segments to discern if vascular morphology varied between sites. Crescentic and circumferential lymphocytic phlebitis is more common in viable bowel than in the ischemic segment. A nonsignificant trend was found for increased crescentic morphology between intact bowel remote from the ischemic focus compared with that adjacent to the ischemic focus. Hallmarks of ischemic bowel are necrotizing phlebitis and thrombi formation. Thrombophlebitis morphology is distinctly different in viable and ischemic bowel, changing from the classic lymphocytic to necrotizing lesions respectively.

  7. O poder das crianças: estratégias de influência na perspectiva das mães

    OpenAIRE

    Rei, Ana Cristina Conceição Valente

    2009-01-01

    Mestrado em Marketing / Classificação JEL: M31, M39 A sociedade actual reconhece o crescente poder que as crianças têm na família. Por isso, cada vez mais, as crianças são alvo de investigação científica e de campanhas publicitárias por parte das empresas. Mas, apesar do crescente interesse demonstrado por este target, algumas questões relacionadas com a forma como a influência é exercida permanecem por explorar. A revisão bibliográfica revelou que existe escassez de informação no que diz ...

  8. Dense Deposit Disease Mimicking a Renal Small Vessel Vasculitis

    Science.gov (United States)

    Singh, Lavleen; Bhardwaj, Swati; Sinha, Aditi; Bagga, Arvind; Dinda, Amit

    2016-01-01

    Dense deposit disease is caused by fluid-phase dysregulation of the alternative complement pathway and frequently deviates from the classic membranoproliferative pattern of injury on light microscopy. Other patterns of injury described for dense deposit disease include mesangioproliferative, acute proliferative/exudative, and crescentic GN. Regardless of the histologic pattern, C3 glomerulopathy, which includes dense deposit disease and C3 GN, is defined by immunofluorescence intensity of C3c two or more orders of magnitude greater than any other immune reactant (on a 0–3 scale). Ultrastructural appearances distinguish dense deposit disease and C3 GN. Focal and segmental necrotizing glomerular lesions with crescents, mimicking a small vessel vasculitis such as ANCA-associated GN, are a very rare manifestation of dense deposit disease. We describe our experience with this unusual histologic presentation and distinct clinical course of dense deposit disease, discuss the pitfalls in diagnosis, examine differential diagnoses, and review the relevant literature. PMID:26361799

  9. Arterial cross-section reconstruction from bi-plane X-ray shadowgraphs

    International Nuclear Information System (INIS)

    Fenster, P.; Barba, J.; Suardiaz, M.; Wong, K.K.; Herrold, E.M.; Kenet, R.O.; Borer, J.S.

    1987-01-01

    An iterative algorithm was used to reconstruct the cross-section of a crescent-shaped vessel lumen. The accuracy of this method was evaluated by comparing reconstruction error in the presence of Gaussian noise of different magnitudes. The sensitivity of the reconstruction algorithm to initial boundary constraint error was also evaluated. Using this algorithm, the reconstruction error was 1.7% when applied to crescent shaped lumen. This error was found to increase significantly with increasing Gaussian noise (error range: 5.75 - 20.75% for noise variance 1-8 pixels). Median filtering of the noise-degraded density profiles improved the reconstruction error (error range: 3.25 - 10.5% for noise variance 1-8 pixels). The mean reconstruction error was not strongly influenced by initial boundary constraint error. The algorithm provided reasonable reconstruction results when applied to X-ray image derived density profiles of known luminal shapes

  10. A study on relationship between organizational climate and creativity

    Directory of Open Access Journals (Sweden)

    Ali Akbar Ahmadi

    2013-11-01

    Full Text Available This study examines the relationship between organizational climate and women employees' creativity of Tabriz Red Crescent Organization. The research method is descriptive correlation performed among 120 women employed at the Red Crescent and 100 cases were selected for the proposed study. For data collection, Hoy and Miskel (2005's organizational climate and Randsyp creativity questionnaires with 0.78 and 0.82 Cronbach's alpha coefficients were used. Pearson correlation and multiple regressions were used to analyze research hypotheses. Results showed that there was a significant relationship between two indices of manager and subordinate behaviors and creativity. In addition, in investigating the relationship between climate and creativity components, findings showed that there was a significant relationship only between cooperation and pretending to job dimensions and creativity. This study also has shown that managers' behavior is closed and employees' behavior is more open than managers are.

  11. Aplicação de gorduras "low trans" à base de soja, formuladas utilizando rede neural artificial, em biscoitos laminados

    OpenAIRE

    Alessandra Afonso Teixeira Penteado

    2012-01-01

    Resumo: Após as crescentes divulgações na mídia dos malefícios à saúde causados pela ingestão de gorduras trans e a Resolução RDC 360, de 23 de dezembro de 2003, que estabelece a obrigatoriedade de declaração dos níveis de gordura trans nos rótulos dos alimentos industrializados, nota-se uma crescente demanda por produtos sem ácidos graxos trans (¿low trans¿). O objetivo principal deste projeto foi aplicar a tecnologia de Redes Neurais Artificiais (RNAs) para a obtenção de blends de gorduras ...

  12. Regional diversity on the timing for the origins of cereal cultivation and domestication in southwest Asia

    DEFF Research Database (Denmark)

    Otaegui, Amaia Arranz; Colledge, Sue; Zapata, Lydia

    2016-01-01

    in regions such as the southern-central Levant and the Upper Euphrates area, but the plant-based subsistence in the eastern Fertile Crescent (southeast Turkey, Iran, and Iraq) focused on the exploitation of plants such as legumes, goatgrass, fruits, and nuts. Around 10.7–10.2 ka Cal BP (early Pre......-Pottery Neolithic B), the predominant exploitation of cereals continued in the southern-central Levant and is correlated with the appearance of significant proportions (∼30%) of domesticated-type cereal chaff in the archaeobotanical record. In the eastern Fertile Crescent exploitation of legumes, fruits, nuts......, and grasses continued, and in the Euphrates legumes predominated. In these two regions domesticated-type cereal chaff (>10%) is not identified until the middle and late Pre-Pottery Neolithic B (10.2–8.3 ka Cal BP). We propose that the cultivation of wild and domesticated cereals developed at different times...

  13. Stalled RNAP-II molecules bound to non-coding rDNA spacers are required for normal nucleolus architecture.

    Science.gov (United States)

    Freire-Picos, M A; Landeira-Ameijeiras, V; Mayán, María D

    2013-07-01

    The correct distribution of nuclear domains is critical for the maintenance of normal cellular processes such as transcription and replication, which are regulated depending on their location and surroundings. The most well-characterized nuclear domain, the nucleolus, is essential for cell survival and metabolism. Alterations in nucleolar structure affect nuclear dynamics; however, how the nucleolus and the rest of the nuclear domains are interconnected is largely unknown. In this report, we demonstrate that RNAP-II is vital for the maintenance of the typical crescent-shaped structure of the nucleolar rDNA repeats and rRNA transcription. When stalled RNAP-II molecules are not bound to the chromatin, the nucleolus loses its typical crescent-shaped structure. However, the RNAP-II interaction with Seh1p, or cryptic transcription by RNAP-II, is not critical for morphological changes. Copyright © 2013 John Wiley & Sons, Ltd.

  14. Simulação do processo de desasfaltação de petroleo pesado para obtenção de asfaltenos e oleo lubrificante

    OpenAIRE

    Filipe Augusto Barral Quirino

    2009-01-01

    Resumo: A desasfaltação do petróleo é um dos principais processos primários no refino de óleo cru. O estudo do processo de desasfaltação tem merecido atenção considerável nas últimas décadas, devido ao aumento das reservas de óleos crus pesados. No Brasil, grande parte das reservas exploradas produz óleos pesados, uma vez que a crescente redução no processamento de petróleos leves aliada à crescente demanda por combustíveis e lubrificantes de melhor qualidade força a indústria nacional de pet...

  15. Accessible solitons of fractional dimension

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Wei-Ping, E-mail: zhongwp6@126.com [Department of Electronic and Information Engineering, Shunde Polytechnic, Guangdong Province, Shunde 528300 (China); Texas A& M University at Qatar, P.O. Box 23874, Doha (Qatar); Belić, Milivoj [Texas A& M University at Qatar, P.O. Box 23874, Doha (Qatar); Zhang, Yiqi [Key Laboratory for Physical Electronics and Devices of the Ministry of Education & Shaanxi Key Lab of Information Photonic Technique, Xi’an Jiaotong University, Xi’an 710049 (China)

    2016-05-15

    We demonstrate that accessible solitons described by an extended Schrödinger equation with the Laplacian of fractional dimension can exist in strongly nonlocal nonlinear media. The soliton solutions of the model are constructed by two special functions, the associated Legendre polynomials and the Laguerre polynomials in the fraction-dimensional space. Our results show that these fractional accessible solitons form a soliton family which includes crescent solitons, and asymmetric single-layer and multi-layer necklace solitons. -- Highlights: •Analytic solutions of a fractional Schrödinger equation are obtained. •The solutions are produced by means of self-similar method applied to the fractional Schrödinger equation with parabolic potential. •The fractional accessible solitons form crescent, asymmetric single-layer and multilayer necklace profiles. •The model applies to the propagation of optical pulses in strongly nonlocal nonlinear media.

  16. T1-weighted MR images in radiographic stage of fragmentation of Legg-Calve-Perthes disease

    Energy Technology Data Exchange (ETDEWEB)

    Kumasaka, Yukiko; Watanabe, Hitoshi; Kishimoto, Harumasa; Higashihara, Tokuro (Kansai Rosai Hospital, Amagasaki, Hyogo (Japan)); Harada, Koshi; Kozuka, Takahiro

    1991-04-01

    Seven femoral heads of Legg-Calve-Perthes disease (LCPD) in radiographic stage of fragmentation were examined in 6 boys by MRI. Characteristic appearances of capital epiphysis and the surrounding cartilaginous structures can be seen. These were proved by four indices for measurement of cartilaginous contour. Cartilaginous contour of epiphysis is enlarged with crescent like deformity resulting from deformity of growth plate. Characteristic layers or honeycomb pattern of extremely low and intermediate signal intensity can be seen. (author).

  17. T1-weighted MR images in radiographic stage of fragmentation of Legg-Calve-Perthes disease

    International Nuclear Information System (INIS)

    Kumasaka, Yukiko; Watanabe, Hitoshi; Kishimoto, Harumasa; Higashihara, Tokuro; Harada, Koshi; Kozuka, Takahiro.

    1991-01-01

    Seven femoral heads of Legg-Calve-Perthes disease (LCPD) in radiographic stage of fragmentation were examined in 6 boys by MRI. Characteristic appearances of capital epiphysis and the surrounding cartilaginous structures can be seen. These were proved by four indices for measurement of cartilaginous contour. Cartilaginous contour of epiphysis is enlarged with crescent like deformity resulting from deformity of growth plate. Characteristic layers or honeycomb pattern of extremely low and intermediate signal intensity can be seen. (author)

  18. Agricultural origins on the Anatolian plateau

    OpenAIRE

    Baird, D.; Fairbairn, A.; Jenkins, Emma L.; Martin, L.; Middleton, C.; Pearson, J.; Asouti, E.; Edwards, Y.; Kabukcu, C.; Mustafaoğlu, G.; Russell, N.; Bar-Yosef, O.; Jacobsen, G.; Wu, X.

    2018-01-01

    This paper explores explanations for, and consequences of, the early appearance of food production outside the Fertile Crescent of Southwest Asia, where it had originated in the 10th/9th millennium cal BC. We present evidence that cultivation appeared in Central Anatolia through adoption by indigenous foragers in the mid 9th millennium cal BC, but also demonstrate that uptake was not uniform, and that some communities chose to actively disregard cultivation. Adoption of cultivation seems to h...

  19. Swarm Tactics and the Doctrinal Void: Lessons from the Chechen Wars

    Science.gov (United States)

    2008-06-01

    classify as a vapor swarm, the Finnish guerrillas “Using their quick-firing Suomi submachine guns, the skiers appeared out of nowhere, poured a...our knowledge that we hope to answer, provide a departure point for further existing work, and set the foundation for analysis and validation of the...scholarly literature on the Soviet Afghan War, three works stand out as contributing to our body of knowledge on swarming. Tactics of the Crescent

  20. A FALSE POSITIVE FOR OCEAN GLINT ON EXOPLANETS: THE LATITUDE-ALBEDO EFFECT

    International Nuclear Information System (INIS)

    Cowan, Nicolas B.; Abbot, Dorian S.; Voigt, Aiko

    2012-01-01

    Identifying liquid water on the surface of planets is a high priority, as this traditionally defines habitability. One proposed signature of oceans is specular reflection ('glint'), which increases the apparent albedo of a planet at crescent phases. We post-process a global climate model of an Earth-like planet to simulate reflected light curves. Significantly, we obtain glint-like phase variations even though we do not include specular reflection in our model. This false positive is the product of two generic properties: (1) for modest obliquities, a planet's poles receive less orbit-averaged stellar flux than its equator, so the poles are more likely to be covered in highly reflective snow and ice; and (2) we show that reflected light from a modest-obliquity planet at crescent phases probes higher latitudes than at gibbous phases, therefore a planet's apparent albedo will naturally increase at crescent phase. We suggest that this 'latitude-albedo effect' will operate even for large obliquities: in that case the equator receives less orbit-averaged flux than the poles, and the equator is preferentially sampled at crescent phase. Using rotational and orbital color variations to map the surfaces of directly imaged planets and estimate their obliquity will therefore be a necessary pre-condition for properly interpreting their reflected phase variations. The latitude-albedo effect is a particularly convincing glint false positive for zero-obliquity planets, and such worlds are not amenable to latitudinal mapping. This effect severely limits the utility of specular reflection for detecting oceans on exoplanets.

  1. Nutrient enhanced coastal ocean productivity in the north Gulf of Mexico: understanding the effects of nutrients on a coastal ecosystem

    OpenAIRE

    1999-01-01

    The continental shelf adjacent to the Mississippi River is a highly productive system, often referred to as the fertile fisheries crescent. This productivity is attributed to the effects of the river, especially nutrient delivery. In the later decades of the 2oth century, though, changes in the system were becoming evident. Nutrient loads were seen to be increasing and reports of hypoxia were becoming more frequent. During most recent summers, a broad area (up to 20,000 krn2) of near botto...

  2. Giant unusual shaped chronic subdural hematoma in a patient with untreated congenital hydrocephalus

    OpenAIRE

    Mishra, Arvind; Ojha, Bal. K.; Chandra, Anil; Srivastava, Chhitij; Singh, Sunil Kumar

    2011-01-01

    Subdural hematoma is a well known complication of ventriculoperitoneal shunt insertion for hydrocephalus and usually spreads out over the cerebral convexity, and appears as a crescent shaped lesion on imaging. Chronic subdural hematoma in a case of untreated compensated congenital hydrocephalus has not been reported in English literature. We report the rare case of an adult with congenital hydrocephalus with a huge unusual shaped hemispheric subdural hematoma.

  3. Anatomia das Parcerias Público Privadas : A sua criação, financiamento e renegociações

    NARCIS (Netherlands)

    Miranda Sarmento, J.J.; Renneboog, Luc

    2017-01-01

    A crescente importância das Parcerias Público Privadas (PPPs), não apenas em Portugal, mas também ao nível Europeu, não tem sido acompanhada de uma análise, quer académica, quer ao nível dos diversos intervenientes, completa e exaustiva sobre esta temática. Neste artigo procuramos fazer uma análise

  4. Archaeological Salvage of the Joso Trestle Construction Camp, 45-FR-51 Lower Monumental Project.

    Science.gov (United States)

    1981-01-01

    Manager, Marketing Department, Crescent Foods, Seattle; Terry Corrado Spyrison, Corrado Cutlery , Chicago; Jacqueline Stone, Assistant Curator, U.S...gold "D. Corrado, 204 No. Clark Str., Chicago, Ill." The Corrado Cutlery Co., which has been in business for some 75 years, reports that they probably...locating parties (McHenry 1903:75; Beahan 1904:87-88; Lavis 1906:43) can give some idea of the variety of edibles that might be represented in

  5. CT findings in a case of neonatal acute subdural hematoma

    International Nuclear Information System (INIS)

    Koshu, K.; Horie, Y.; Hirashima, Y.; Endo, S.; Takaku, A.

    1981-01-01

    The CT findings in a case of neonatal accute subdural hematoma are presented. CT demonstrated a crescentic high density area in the subdural space over the left cerebral hemisphere and an oval high density area in the left occipital region. The latter was suspected of being an intracerebral hematoma. Emergency craniotomy revealed that the high density area was due to a subdural hematoma between the occipital lobe and the tentorium cerebelli. (orig.)

  6. Nonlocal Effects of Crack Curving.

    Science.gov (United States)

    1982-07-01

    close vTcinity of the crack tip. Supported by the Office of Naval Research. 2 For brittle solids, a fracture criterion based on the maximum tensile...Reidel Pubi. Co. Dordrecht. Holland. pp. 271-318, 1978. [13] A.S. Jayatilaka, Fracture of Engineering Brittle Materials, Appl. Sci. Publishers, London...Crescent leach Road, Glen Cove * Long Island, New Tork 11542 Commanding Officer (2) U.s Amy Research Office PO, Sax 12211 Research Triangle Park. C 27709 8

  7. Line Crack Subject to Antiplane Shear.

    Science.gov (United States)

    1978-07-01

    shear is obtained for the initiation of fracture. If the concept of the surface tension is usedone is able to calculate the cohesive stress for brittle ...Expression of the Griffith -racture criterion for brittle fracture. We have arrived at this result via the maximum shear-stress hypothesis, rather than...Crescent Beach Road, Glen Cove Prof. G.S. Heller Long Island, New York 11542 Division of Engineering Brown University Prof. Daniel

  8. AP-VAS 2012 case report: two patients with rheumatoid arthritis suspected of relapsed microscopic polyangiitis after initiation of dialysis

    OpenAIRE

    Sugahara, Mai; Nishi, Takahiro; Tanaka, Shinji; Kurita, Noriaki; Sai, Keiko; Kano, Tatsuya; Nishio, Kyosuke; Sugimoto, Tokuichiro; Mise, Naobumi

    2013-01-01

    We report two patients with rheumatoid arthritis (RA) who were suspected of microscopic polyangiitis during maintenance dialysis. Case 1 was a 52-year-old woman with RA diagnosed at the age of 38 years and treated successfully with gold compounds. At the age of 43 years, she presented with progressive renal dysfunction and abnormal urine sediments, and a renal biopsy revealed crescentic nephritis with advanced glomerular sclerosis. Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA...

  9. Padrões reprodutíveis de viscosidade para uso em videofluoroscopia e na terapia de reabilitação de pacientes disfágicos

    OpenAIRE

    Costa, Milton M. B.; Almeida, Juliana T. de; Sant'Anna, Eliane; Pinheiro, Gláucia M.

    2007-01-01

    BACKGROUND: Usually the suitable consistence identified and indicated as safe by videofluoroscopic method has been empirically obtained by association of barium sulfate solution with meals. However, it has been evidenced to be very difficult to reproduce this consistence in nutritional rehabilitation therapy from subjective information. AIM: To build two reproductive similar crescent viscosities series of solutions, with and without barium sulfate, to be used, the first, as radiological contr...

  10. Indicators of Information Society Measurement :

    Directory of Open Access Journals (Sweden)

    Hind Elwy

    2006-09-01

    Full Text Available The indicator of information society describe the infrastructure of information and communication technology ; as well as it’s use and it’s production in different estate of society. The importance economic and social of tic is crescent in modern society. and the presentation of tendency inform above the situation of information society . in this article we want to describe the indicator of tic in Algeria according to librarian’s vision in Mentouri university

  11. Compostos antimicrobianos produzidos por Streptomyces Spp.

    OpenAIRE

    Silva, Ingrid Reis da

    2012-01-01

    O aumento crescente de bact?rias resistentes a antibi?ticos incentiva ? pesquisa por novas subst?ncias antibacterianas. Diante disso, a sele??o de microrganismos com potencial para a produ??o de novos compostos antimicrobianos tem sido amplamente estudada. Dentre estes microrganismos uma especial aten??o ? dada aos actinomicetos que apresentam capacidade de produzir uma variedade de compostos bioativos como antibi?ticos, antif?ngicos, antitumorais entre outros compostos que pod...

  12. A CORRUPÇÃO NO FUTEBOL BRASILEIRO

    Directory of Open Access Journals (Sweden)

    Carlos Azevedo

    2001-01-01

    Full Text Available RESUMO: o texto apresenta síntese de partes do Relatório final da Comissão Parlamentar de Inquérito da Câmara dos Deputados, que investigou as relações entre a CBF e a multinacional Nike (CPI CBF-Nike, além de aspectos pertinentes ao crescente e inexplicável endividamento da entidade federativa maior do futebol brasileiro.

  13. AS MÚLTIPLAS DETERMINAÇÕES DO PROGRAMA NACIONAL DE PRODUÇÃO E USO DO BIODIESEL

    Directory of Open Access Journals (Sweden)

    Rosana Akemi Pafunda

    2012-07-01

    Full Text Available Perante a crescente demanda energética e o prenúncio do processo de esgotamento da matriz de origem fóssil, na qual se assenta o consumo mundial, o Brasil tem se destacado como o pioneiro no desenvolvimento de fontes alternativas de energia, cujo caráter se fundamenta preferencialmente, por representar um modelo renovável e ecologicamente viável.    

  14. In/visible conflicts: NGOs and the visual politics of humanitarian photography

    OpenAIRE

    Dencik, Lina; Allan, Stuart

    2017-01-01

    This article examines the diverse factors shaping NGO involvement with humanitarian\\ud photography, paying particular attention to co-operative relationships with\\ud photojournalists intended to facilitate the generation of visual coverage of crises\\ud otherwise marginalised, or ignored altogether, in mainstream news media. The\\ud analysis is primarily based on a case study drawing upon 26 semi-structured interviews\\ud with NGO personnel (International Red Cross/Red Crescent Movement, Oxfam a...

  15. Acute kidney injury with hypoxic respiratory failure

    OpenAIRE

    Neubert, Zachary; Hoffmann, Paul; Owshalimpur, David

    2014-01-01

    A 27-year-old Caucasian man was transferred from a remote clinic with acute kidney injury for the prior 7–10 days preceded by gastroenteritis. His kidney biopsy showed non-specific mesangiopathic glomerular changes, minimal tubulointerstitial disease without sclerosis, crescents, nor evidence of vasculitis. On his third hospital day, he developed acute hypoxic respiratory failure requiring intubation and mechanical ventilation. Pulmonary renal syndromes ranked highest on his differential diag...

  16. The Biblical Matrix of Economics

    OpenAIRE

    Grigore PIROŞCĂ; Angela ROGOJANU

    2012-01-01

    The rationale of this paper is a prime pattern of history of economic thought in the previous ages of classic ancient times of Greek and Roman civilizations using a methodological matrix able to capture the mainstream ideas from social, political and religious events within the pages of Bible. The economic perspective of these events follows the evolution of the seeds of economic thinking within the Fertile Crescent, focused on the Biblical patriarchic heroes’ actions, but a...

  17. Turismo, imagem do lugar e competitividade na globalização

    OpenAIRE

    Aldo Gomes Leandro

    1997-01-01

    A produção de imagens turísticas dos lugares atravessa um novo momento diante das novas estratégias de marketing e propaganda. A gestão de marcas é o seu aspecto mais recente face à crescente competitividade entre os lugares na globalização. Assim, este trabalho aborda a importância da imagem do lugar para as políticas do poder público

  18. Turismo, imagem do lugar e competitividade na globalização

    Directory of Open Access Journals (Sweden)

    Aldo Gomes Leandro

    1997-04-01

    Full Text Available A produção de imagens turísticas dos lugares atravessa um novo momento diante das novas estratégias de marketing e propaganda. A gestão de marcas é o seu aspecto mais recente face à crescente competitividade entre os lugares na globalização. Assim, este trabalho aborda a importância da imagem do lugar para as políticas do poder público

  19. Degradação ambiental e Ongs na Amazônia Continental

    Directory of Open Access Journals (Sweden)

    Argemiro Procópio Filho

    2010-11-01

    Full Text Available O presente artigo tem como foco a crescente degradação ambiental a qual sofre a região Amazônica.  Nesse sentido, buscar-se-á expor o papel das ONGs no que se refere à essa preocupante questão, além de expor as posições oficiais dos países que possuem parcelas dessa grande região.

  20. Modeling Aerosol Particle Deposition on a Person Using Computational Fluid Dynamics

    Science.gov (United States)

    2015-04-03

    Consulting Inc. 534 Paradise Crescent, Waterloo, Ontario PWGSC Contractor Number: W7702-155701/001/EDM Contract Scientific Authority: Eugene Yee...Fluid Dynamics Final Report Hua Ji and Fue-Sang Lien Waterloo CFD Engineering Consulting Inc. (WATCFD) 534 Paradise Cres, Waterloo Ontario, N2L 3G1...enters a new eddy. The time step is chosen to be the minimum of one fifth of the eddy lifetime or one fifth of the minimum side length of the local

  1. Apostando na Continuidade? O Eleitor Brasileiro ante os Dilemas do Governo Lula

    Directory of Open Access Journals (Sweden)

    Christiane Ströh

    2014-06-01

    Full Text Available Diante dos recentes escândalos no cenário político brasileiro, motivados pela descoberta dos esquemas de corrupção para a construção de maiorias parlamentares através da compra de votos para o atual governo, as crescentes intenções de voto em Lula podem parecer estranhas – ou até mesmo pouco éticas.

  2. The University of Amsterdam at TREC 2012

    Science.gov (United States)

    2012-11-01

    lady , weight, ap, loss, major, insurance, rate, role, response, plays, atlanta, rising, oprah, childhood, crescent Table 5: Example topics and their...by the CLARIN-nl program, the Dutch national program COMMIT, the ESF Research Net- work Program ELIAS, the Elite Network Shifts project funded by the...Royal Dutch Academy of Sciences (KNAW), and the Netherlands eScience Center under project number 027.012.105. 6 References [1] Balasubramanian, N. and

  3. The filamentary nebulae S 188

    International Nuclear Information System (INIS)

    Rosado, M.; Kwitter, K.B.

    1982-01-01

    The crescent shaped nebula S 188 is identified as a planetary nebula (PN) of Peimbert's Type I on the basis of its observed nebula spectrum. New FP interferometric work allows to determine the systemic motion of this nebula. The derived kinematical distance exceeds Cudworth's distance estimate supporting the idea that Peimbert's Type I PNs have larger ejected masses than typical PNs. A discussion about the origin of its non-spherical shape is also given. (author)

  4. Nuclear safeguards research. Program status report. Progress report, September--December 1975

    International Nuclear Information System (INIS)

    1976-04-01

    This report presents the status of the Nondestructive Assay R and D program of the LASL Nuclear Safeguards Research Group, R-1, covering the period September-December 1975. It covers: holdup measurements at the Kerr-McGee Pu facility at Crescent, Okla.; calculations for Random Driver; instrument development and measurement controls; ERDA nondestructive assay training program; and in-plant dynamic materials control (DYMAC) program. 22 figures, 5 tables

  5. Extracapillary proliferation in IgA nephropathy; recent findings and new ideas.

    Science.gov (United States)

    Nasri, Hamid; Mubarak, Muhammed

    2015-01-01

    IgA nephropathy (IgAN) is an autoimmune disorder and is the most common form of primary glomerulonephritis (GN) worldwide. Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched. It is a slowly progressing disorder that leads to end-stage renal disease (ESRD) in up to 50% of the patients within 25 years of the onset of the disease. IgAN is defined by predominant IgA deposition in the mesangial area on immunofluorescence (IF) microscopy. Its histology varies from mild focal segmental proliferation of mesangial cells to severe diffuse global proliferation with extracapillary proliferation (crescent formation). The Oxford classification, designed in 2009, is a new classification for the evaluation of morphologic lesions of IgAN. This classification, containing four pathology variables, was found to have prognostic implications. The variables included are mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S) and the proportion of interstitial fibrosis and tubular atrophy (T). However, crescents were not included in the Oxford classification. In this mini-review, we describe the recent publications about the significance of extracapillary proliferation in IgAN and we conclude that, there is much controversy about the role of extracapillary proliferation as a significant prognostic factor in IgAN. Hence, it is important to re-consider crescents in IgAN patients. Therefore, we suggest further investigations on this aspect of IgAN disease.

  6. Diagnostic criterial to differentiate medial meniscal injury from degenerative changes on 99mTc-MDP knee SPECT in patients with chronic knee pain

    International Nuclear Information System (INIS)

    Paeng, Jin Chul; Chung, June Key; Kang, Won Jun; So, Young; Lee, Dong Soo; Lee, Myung Chul; Yoo, Jae Ho; Lee, Myung Chul; Jeong, Hwan Jeong

    2003-01-01

    In patients with chronic knee pain, the diagnostic performance of 99m Tc-MDP knee SPECT for internal derangement of knee is deteriorated due to degenerative changes. In this study, we tried to establish diagnostic criteria to differentiate medial meniscal injury (MMI) from degenerative change (DC) when the uptake in increased in medial compartment. A total of 49 knee SPECT of the patients with chronic(more than 3 months) knee pain, which showed increased 99m Tc-MDP uptake in the medial compartment, were included in this study. The diagnosis was confirmed by arthroscopy. On knee SPECT, 3 diagnosic criteria for MMI were investigated. In Criterion, I, MMI was diagnosed when crescentic uptake was observed in the medial tibial plateau. In Criterion II, crescentic uptake was further classified into anterior, mid, posterior, and diffuse patterns, according to the location of maximal uptake; and only crescentic mid, posterior, and diffuse patterns were diagnosed as MMI. In Criterion III, MMI was diagnosed when medial tibial plateau showed higher activity then medial femoral condyle. The diagnostic performance of the 3 criteria was compared. The sensitivity and specificity were 93% and 14% in Criterion I, 89% and 38% in Criterion II, and 75% and 67% in Criterion III, respectively. Criterion III had significantly improve diagnostic performance, especially, specificity. In this study, we established a practical diagnostic criterion to differentiate MMI from DC on knee SPECT. The result is helpful to improve the diagnostic value of knee SPECT as a screening test for chronic knee pain

  7. Can the Bruckner test be used as a rapid screening test to detect significant refractive errors in children?

    Directory of Open Access Journals (Sweden)

    Kothari Mihir

    2007-01-01

    Full Text Available Purpose: To assess the suitability of Brückner test as a screening test to detect significant refractive errors in children. Materials and Methods: A pediatric ophthalmologist prospectively observed the size and location of pupillary crescent on Brückner test as hyperopic, myopic or astigmatic. This was compared with the cycloplegic refraction. Detailed ophthalmic examination was done for all. Sensitivity, specificity, positive predictive value and negative predictive value of Brückner test were determined for the defined cutoff levels of ametropia. Results: Ninety-six subjects were examined. Mean age was 8.6 years (range 1 to 16 years. Brückner test could be completed for all; the time taken to complete this test was 10 seconds per subject. The ophthalmologist identified 131 eyes as ametropic, 61 as emmetropic. The Brückner test had sensitivity 91%, specificity 72.8%, positive predictive value 85.5% and negative predictive value 83.6%. Of 10 false negatives four had compound hypermetropic astigmatism and three had myopia. Conclusions: Brückner test can be used to rapidly screen the children for significant refractive errors. The potential benefits from such use may be maximized if programs use the test with lower crescent measurement cutoffs, a crescent measurement ruler and a distance fixation target.

  8. A case of chronic subdural hematoma showing a double-loculated type on CT

    International Nuclear Information System (INIS)

    Usami, Bin; Yoshida, Tsuyoshi; Shibata, Taichiro; Nagai, Hajime; Takagi, Terumasa.

    1982-01-01

    A 69-year-old woman sustained a minor head trauma. One month later she came to the hospital complaining of right motor weakness. This slight right-sided hemiparesis almost completely improved, without surgical treatment, within several days. The same hemiparesis recurred 10 days later. A plain CT scan showed a double-loculated crescent lesion which was separated by a bandlike high-density line, over the left cerebral hemisphere. The outer crescent lesion was mixed in density, low density in the upper section and high-density in the lower portion. The inner crescent lesion was low density. Although a chronic subdural hematoma was found and evacuated at operation, fluid accumulated again 10 days later. The hematoma was thus evacuated again, and the thick neo-membranes were removed as extensively as possible. The outer most neo-membrane just under the dura mater and the intermediate neo-membrane coinciding with a high-density line on CT were in the same proliferation stage, consisting of loose connective tissue with hypertrophic fibroblasts, well-developed sinusoids, and numerous hemosiderine granules. They also showed partial calcium deposition, evidence that these neo-membranes were very old, pre-existing ones. Based on the above-mentioned facts, it was speculated that the outer hematoma was formed by a splitting of a pre-existing, old outer membrane of an inner hematoma due to multiple intra-membraneous bleedings. (J.P.N.)

  9. Wherever We Find Friends there Begins a New Life: Tagore and China

    Directory of Open Access Journals (Sweden)

    Jana Rošker

    2010-12-01

    Full Text Available Tagore made a deep impression upon the Chinese culture and society. In 1923, the Jiangxue she 講學社 (Beijing Lecture Association invited Rabindranath Tagore to deliver a series of talks. The Jiangxue she Association was established in September 1920 and represented one of the many institutions that came to life in China during the May Fourth Movement. Since then, almost all of his works in English have been translated into Chinese. He came to China just when the latter was beginning her Renaissance and his visit certainly gave a great impetus to this new movement. His poems of Stray Birds and The Crescent Moon have created new styles of prosody in the new Chinese poetry. A Crescent Moon Society (for poetry and a Crescent Moon magazine were started immediately after this event by Hu Shi 胡适 (Hu 2002: 90. During his visit, Tagore raised two basic questions, one about the relation between tradition and modernity, and the other about the usual identification of modernisation with Westernisation. Since the May Fourth Movement, China has also been concerned with these questions and Chinese intellectuals have come out with different answers. These questions, however, were important not only for China but for India as well. Such debates and the revaluation of various answers represented the most important condition for a consolidation of new ideologies, which formed a political basis for the changing societies of both countries.

  10. DETECTING OCEANS ON EXTRASOLAR PLANETS USING THE GLINT EFFECT

    International Nuclear Information System (INIS)

    Robinson, Tyler D.; Meadows, Victoria S.; Crisp, David

    2010-01-01

    Glint, the specular reflection of sunlight off Earth's oceans, may reveal the presence of oceans on an extrasolar planet. As an Earth-like planet nears crescent phases, the size of the ocean glint spot increases relative to the fraction of the illuminated disk, while the reflectivity of this spot increases. Both effects change the planet's visible reflectivity as a function of phase. However, strong forward scattering of radiation by clouds can also produce increases in a planet's reflectivity as it approaches crescent phases, and surface glint can be obscured by Rayleigh scattering and atmospheric absorption. Here, we explore the detectability of glint in the presence of an atmosphere and realistic phase-dependent scattering from oceans and clouds. We use the NASA Astrobiology Institute's Virtual Planetary Laboratory three-dimensional line-by-line, multiple-scattering spectral Earth model to simulate Earth's broadband visible brightness and reflectivity over an orbit. Our validated simulations successfully reproduce phase-dependent Earthshine observations. We find that the glinting Earth can be as much as 100% brighter at crescent phases than simulations that do not include glint, and that the effect is dependent on both orbital inclination and wavelength, where the latter dependence is caused by Rayleigh scattering limiting sensitivity to the surface. We show that this phenomenon may be observable using the James Webb Space Telescope paired with an external occulter.

  11. Consumo e digestibilidade do feno de capim-braquiária em bovinos de corte sob suplementação com mistura contendo sulfato de amônio, caseína e uréia Intake and digestibility of palisade grass hay by beef cattle supplemented with a mixture containing ammonium sulphate, casein and urea

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Gomes da Silva de Rezende

    2008-04-01

    Full Text Available Avaliaram-se o consumo e a digestibilidade dos nutrientes de dietas contendo feno de capim-braquiária (Brachiaria brizantha cv. MG4 de baixa qualidade e de diferentes níveis protéicos. Os tratamentos avaliados foram: controle (somente feno e feno com adição crescente, via infusão ruminal, da mistura sulfato de amônio, caseína e uréia (0,5:1,0:4,5 de modo a elevar em +2, +4, +6 e +8% o nível de PB das dietas. Os dados foram analisados em delineamento quadrado latino, com cinco níveis de suplementação, cinco animais e cinco períodos. A adição de quantidades crescentes de nitrogênio não-protéico (NNP à dieta teve efeito quadrático sobre os consumos de matéria seca (MS, matéria orgânica (MO, fibra em detergente neutro (FDN e extrato etéreo (EE. O maior consumo de MS foi observado com o nível de 10,5% PB. Não foram observados efeitos dos níveis de PB sobre os coeficientes de digestibilidade de MS, MO, FDN e EE. Houve efeito linear crescente sobre o coeficiente de digestibilidade da PB, que apresentou valores de 57,4; 66,9; 73,6; 77,3 e 81,7% nos níveis de PB de 6,3; 8,5; 10,5; 12,63 e 14,8%, respectivamente. O nível de 10,5% de PB foi o ponto crítico para a obtenção de resposta máxima para os consumos de MS (7,7 kg/dia e MO (7,2 kg/dia. A suplementação com compostos nitrogenados em quantidades que permitam elevar o nível protéico da dieta a 10,5% otimiza o uso de forragens de baixa qualidade.The intake and digestibilility of the nutrients of diets containing palisade grass (Brachiaria brizantha cv. MG4 hay of low quality and different protein levels were evaluated. The evaluated treatments were control (only hay and hay with crescent addition, by rumen infusion, of the mixture containing ammonium sulphate, casein end urea (0.5:1.0:4.5 in way to elevate in +2, +4, +6 and +8% the CP level in the diets. A Latin square experimental design with five levels supplementation, five animals and five periods was used. The

  12. Densidades de plantio e doses de biofertilizante na produção de capim-limão Density and biofertilizer levels for lemon grass production

    Directory of Open Access Journals (Sweden)

    Arie F Blank

    2007-09-01

    Full Text Available O objetivo do trabalho foi avaliar o efeito de densidades de plantio e doses de biofertilizante comercial na produção de capim-limão (Cymbopogon citratus (D.C. Stapf. O experimento foi implantado em parcelas subdivididas com três repetições, colocando-se nas parcelas as densidades de plantio (33.333, 49.382, 55.555 e 111.111 plantas ha-1 e nas subparcelas as doses de biofertilizante (0; 20; 40 e 60 t ha-1. Foram realizadas nove colheitas em intervalos de 42 dias. Avaliou-se a sobrevivência, a altura de planta, o número de perfilhos por touceira, a massa seca por touceira e da parte aérea, o teor e o rendimento de óleo essencial. O teor de óleo essencial não foi influenciado pelas densidades de plantio e doses de biofertilizante. A densidade crescente resultou em regressões lineares crescentes para o rendimento de óleo essencial e a massa seca da parte aérea e em uma regressão linear decrescente para a massa seca por touceira. A dose de biofertilizante resultou em regressões lineares crescentes para o rendimento de óleo essencial e a massa seca por touceira e da parte aérea. A densidade de 111.111 plantas ha-1 (0,30 x 0,30 m e a dose de biofertilizante de 60 t ha-1 no primeiro ano de cultivo poderão ser recomendados para produção do capim-limão.The aim of this work was to evaluate the plant density and biofertilizer levels on lemon grass (Cymbopogom citratus (D.C. Stapf. The experiment was installed in split plot design with three replications, having plant density as plots (33,333; 49,382; 55,555 and 111,111 plants ha-1 and biofertilizer doses as sub plots (0; 20; 40; 60 t ha-1 year-1. Nine cuttings were realized using an interval of 42 days between cuttings. We evaluated survival, plant height, number of tillers per plant, dry weight per plant and of biomass yield, essential oil content and yield. The essential oil content was not influenced by the plant densities and biofertilizer doses. The crescent density resulted in

  13. The role of CT and MR in diagnosis of aortic dissection

    International Nuclear Information System (INIS)

    Yoon, Kwon Ha; Lim, Tae Hwan; Song, Koun Sik; Min, Kyung Seok; Song, Meong Gun

    1994-01-01

    The purpose of this study was to determine the role of CT and MR imagings in the diagnosis of aortic dissection and differentiation between the true and false lumen. We retrospectively studied forty patients with aortic dissection(AD) diagnosed by imagings or surgery. Of the forty patients, 19 were examined with only CT, 14 with CT and MR, and 7 with MR. Our points of view were(1) the classification of AD according to configuration of intimal flap by cross-sectional imaging, (2) differentiation between the true and false lumens, (3) the course of the false lumen, and (4) detectability of the origin of major branch vessels of the abdominal aorta. The classification by cross-sectional imaging were crescentic(65%), circumferential(15%), flat(12%), and irregular(8%) type, in which false negative diagnosis was made in 1 case of crescentic and circumferential type, respectively. In 2 case of flat type and 1 case of irregular type, the differentiation between the true and false lumen was impossible with CT. The course of the false lumen in descending thoracic aorta revealed counterclock wise rotation(66%), clockwise rotation(5%) or fixed(29%) appearance. MR imaging was superior to CT in the detection of the origin of major branch vessels of the abdominal aorta. The determination of the origin of major branches of abdominal aorta arising from the true and false lumen were impossible in 2 cases in which only CT was done. Diagnosis of crescentic and circumferential types of AD with narrow and thrombosed false lumen was problematic in both CT and MR with no difference of diagnostic accuracy between the two modalities. The differentiation between the true and false lumen was difficult in flat and irregular types with only CT. Therefore, when surgical treatment is considered as in type B aortic dissection, MR imaging is recommended in order to determine the origin of major branch vessels

  14. Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628.

    Science.gov (United States)

    Ma, Frank Y; Han, Yingjie; Nikolic-Paterson, David J; Kolkhof, Peter; Tesch, Greg H

    2015-01-01

    Steroidal mineralocorticoid receptor antagonists (MRAs) are effective in the treatment of kidney disease; however, the side effect of hyperkalaemia, particularly in the context of renal impairment, is a major limitation to their clinical use. Recently developed non-steroidal MRAs have distinct characteristics suggesting that they may be superior to steroidal MRAs. Therefore, we explored the benefits of a non-steroidal MRA in a model of rapidly progressive glomerulonephritis. Accelerated anti-glomerular basement membrane (GBM) glomerulonephritis was induced in groups of C57BL/6J mice which received no treatment, vehicle or a non-steroidal MRA (BR-4628, 5mg/kg/bid) from day 0 until being killed on day 15 of disease. Mice were examined for renal injury. Mice with anti-GBM glomerulonephritis which received no treatment or vehicle developed similar disease with severe albuminuria, impaired renal function, glomerular tuft damage and crescents in 40% of glomeruli. In comparison, mice which received BR-4628 displayed similar albuminuria, but had improved renal function, reduced severity of glomerular tuft lesions and a 50% reduction in crescents. The protection seen in BR-4628 treated mice was associated with a marked reduction in glomerular macrophages and T-cells and reduced kidney gene expression of proinflammatory (CCL2, TNF-α, IFN-γ) and profibrotic molecules (collagen I, fibronectin). In addition, treatment with BR-4626 did not cause hyperkalaemia or increase urine Na+/K+ excretion (a marker of tubular dysfunction). The non-steroidal MRA (BR-4628) provided substantial suppression of mouse crescentic glomerulonephritis without causing tubular dysfunction. This finding warrants further investigation of non-steroidal MRAs as a therapy for inflammatory kidney diseases.

  15. Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628.

    Directory of Open Access Journals (Sweden)

    Frank Y Ma

    Full Text Available Steroidal mineralocorticoid receptor antagonists (MRAs are effective in the treatment of kidney disease; however, the side effect of hyperkalaemia, particularly in the context of renal impairment, is a major limitation to their clinical use. Recently developed non-steroidal MRAs have distinct characteristics suggesting that they may be superior to steroidal MRAs. Therefore, we explored the benefits of a non-steroidal MRA in a model of rapidly progressive glomerulonephritis.Accelerated anti-glomerular basement membrane (GBM glomerulonephritis was induced in groups of C57BL/6J mice which received no treatment, vehicle or a non-steroidal MRA (BR-4628, 5mg/kg/bid from day 0 until being killed on day 15 of disease. Mice were examined for renal injury.Mice with anti-GBM glomerulonephritis which received no treatment or vehicle developed similar disease with severe albuminuria, impaired renal function, glomerular tuft damage and crescents in 40% of glomeruli. In comparison, mice which received BR-4628 displayed similar albuminuria, but had improved renal function, reduced severity of glomerular tuft lesions and a 50% reduction in crescents. The protection seen in BR-4628 treated mice was associated with a marked reduction in glomerular macrophages and T-cells and reduced kidney gene expression of proinflammatory (CCL2, TNF-α, IFN-γ and profibrotic molecules (collagen I, fibronectin. In addition, treatment with BR-4626 did not cause hyperkalaemia or increase urine Na+/K+ excretion (a marker of tubular dysfunction.The non-steroidal MRA (BR-4628 provided substantial suppression of mouse crescentic glomerulonephritis without causing tubular dysfunction. This finding warrants further investigation of non-steroidal MRAs as a therapy for inflammatory kidney diseases.

  16. Rock paintings in Fern Cave, Lava Beds National Monument, California: Not the 1054 A.D. (Crab Nebula) Supernova

    International Nuclear Information System (INIS)

    Armitage, R.A.; Hyman, M.; Rowe, M. W.

    1997-01-01

    On July 4, 1054 A.D. a supernova brighter than Venus appeared in the sky, remaining visible for approximately 23 days and 650 nights. It was chronicled in five independent historic accounts, four in China and one in Japan. For at least 40 years investigators have attributed certain distinctive rock paintings and carvings in the western United States as recordings of the 1054 A.D. supernova. More than twenty such depictions (circle or star-like symbols and a crescent) have been located. Two panels of rock paintings in Lava Beds National Monument, California, one at Fern Cave and one at Symbol Bridge, were listed as recording the 1054 A.D. supernova. The only direct means of assessing the likelihood that a 'supernova' representation records the 1054 A.D. event is to date the rock painting or carving. At Texas A and M University, was developed a plasma-chemical extraction technique that permits to analyze the 14 C in rock paintings, whether the pigments used were charcoal or inorganic Fe- and Mn- oxides and hydroxides with organic binder/vehicles. This paper presents direct 14 C age estimates on a rock painting suggested to represent the 1054 A.D. supernova. Charcoal pigment samples were collected from three figures in proximity at Fern Cave: a crescent pointing downward and two nearby circles, one above and one below the crescent. The AMS 14 C analysis on each sample using this technique show that these images do not represent the 1054 A.D. supernova

  17. Tendências tecnológicas do uso do sisal em compósitos a partir da prospecção em documentos de patentes

    Directory of Open Access Journals (Sweden)

    Felipe Scopel

    2013-01-01

    Full Text Available As fibras naturais têm sido pesquisadas e empregadas de maneira crescente no desenvolvimento de produtos com sustentabilidade econômica, social e ambiental, sendo o sisal uma das mais importantes para o Brasil, pela sua posição de liderança na produção mundial. O presente artigo analisa a evolução temporal e o interesse das empresas e instituições em tecnologias associadas ao sisal, a partir de informações e indicadores extraídos de documentos de patentes no período de 1960 a 2009. Foi verificado o crescente patenteamento associado ao sisal em áreas de química, ciência dos materiais e dos polímeros, com destaque para o reforço do de compósitos plásticos. Além do crescente número de patentes, houve também um expressivo aumento do número de empresas e instituições titulares das patentes, o que reflete a possível desconcentração do mercado nesse crescimento do interesse pelas tecnologias associadas ao sisal. O Brasil, apesar da sua proeminência na produção do sisal, possui pequena presença no patenteamento mundial. Também foi verificada a importância da análise de patentes para o acompanhamento da evolução das tecnologias e interesses, pela disponibilidade de informações públicas que podem ser transformadas em indicadores úteis para análise de tecnologia e mercado associados ao sisal ou a outras áreas tecnológicas.

  18. Estimating seroprevalence of herpes simplex virus type 1 among different Middle East and North African male populations residing in Qatar

    Science.gov (United States)

    Nasrallah, Gheyath K.; Dargham, Soha R.; Mohammed, Layla I.

    2017-01-01

    HSV‐1 epidemiology in the Middle East and North Africa (MENA) remains poorly understood. Our study aimed to measure HSV‐1 antibody prevalence (seroprevalence) and its age‐distribution among select MENA populations residing in Qatar. Sera were collected from male blood donors attending Hamad Medical Corporation 2013‐2015. A total of 2,077 sera were tested for anti‐HSV‐1 antibodies using HerpeSelect® 1 ELISA IgG kits (Focus Diagnostics, Cypress, CA). Robust Poisson regression was conducted to estimate adjusted infection prevalence ratios. Country‐specific HSV‐1 seroprevalence was estimated for 10 national populations: 97.5% among Egyptians, 92.6% among Yemenis, 90.7% among Sudanese, 88.5% among Syrians, 86.5% among Jordanians, 82.3% among Qataris, 81.4% among Iranians, 81.4% among Lebanese, 80.5% among Palestinians, and 77.0% among Pakistanis. Age‐specific HSV‐1 seroprevalence was estimated for Egypt, the Fertile Crescent (Iraq, Jordan, Lebanon, Palestine, and Syria), and Qatar. Seroprevalence increased with age among Fertile Crescent and Qatari nationals. Seroprevalence increased from 70.0% among those aged ≤ 24 years up to 98.0% among those aged ≥55 years among Fertile Crescent nationals. Seroprevalence was consistently above 90% for all ages among Egyptians. HSV‐1 seroprevalence is high in MENA, though with some variation across countries. The seroprevalence appears to have declined among current young age cohorts compared to its levels a few decades ago. PMID:28817197

  19. Diagnostic imaging of acute aortic dissection

    International Nuclear Information System (INIS)

    Ohya, Tohru; Kumazaki, Tatsuo

    1991-01-01

    One hundred and nineteen patients with aortic dissection who underwent diagnostic imaging were reviewed and angiographic findings as well as those of CT were analysed. Thirty eight cases (43.1%) had non-contrast opacified false lumen, the type of which we call 'thrombosed type aortic dissection'. A comparative study of the thrombosed type with the patent type of false lumens was made particularly from the stand point of the characteristic diagnostic imagings (CT and angiography). At the same time, the pitfalls of these imagings in thrombosed type aortic dissection were studied. At the onset the average age of thrombosed type was 62.3 years old, while that of the patent type was 57.3. A statistical significance between the two groups was p<0.05. Thrombosed type in all cases was caused by atherosclerosis, whereas patent type was caused by the Marfan's syndrome in 11 cases. Other clinical findings, such as initial symptoms and blood pressure revealed no significant differences between the two groups. Pre-contrast CT in acute thrombosed type aortic dissection showed 'hyperdense crescent sign' in 89.4%. However, in 3 cases with thrombosed type in which the pre-contrast CT showed 'hyperdense crescent sign' contrast-enhanced CT detected no clear evidence of aortic dissection in the same site. This was due to obscurity induced by contrast medium. Angiographic findings of thrombosed type were classified into 3 groups: normal type, stenosed true lumen type and ulcer-like projection type. The incidence of normal type was estimated to be 48.4%, whereas stenosed true lumen type was 24.2% and ulcer-like projection was 27.7%. The present study concluded that thrombosed type is not rare in acute aortic dissection and contrast-enhanced CT as well as pre-contrast CT, is of great value in diagnosing thrombosed type. 'Hyperdense crescent sign' in pre-contrast CT is characteristic of intramural hematoma. (author)

  20. Imaging features suggestive of a conjoined nerve root on routine axial MRI

    Energy Technology Data Exchange (ETDEWEB)

    Song, Su Jin; Lee, Joon Woo; Kang, Heung Sik [Seoul National University Bundang Hospital, Department of Radiology, Gyeongi-do (Korea); Choi, Ja-Young; Hong, Sung Hwan; Kim, Na Ra [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea); Kim, Ki-Jeong; Chung, Sang-Ki; Kim, Hyun-Jib [Seoul National University Bundang Hospital, Department of Neurosurgery, Gyeongi-Do (Korea)

    2008-02-15

    The purpose of our study is to evaluate imaging features suggestive of a conjoined nerve root on routine axial MRI. Two radiologists and two surgeons retrospectively reviewed the MRI of three cases in which a conjoined nerve root was discovered during operation and found three suggestive signs on routine axial MR images: ''corner'' (asymmetric morphology of the anterolateral corner of the dural sac), ''fat crescent'' (intervening extradural fat between the asymmetric dura and the nerve root), and ''parallel'' signs (visualization of the entire parallel course of the nerve root at the disc level). Two radiologists prospectively found these signs during routine MRI interpretation sessions over a period of 6 months. If one or a combination of signs were noted on axial MR images, contiguous axial scans were additionally obtained. Three cases that were previously found during operations were also included. Prevalence and confidence scores for each sign were assessed on axial T1- and T2-weighted images. Twelve patients showed one or a combination of the three signs, 9 had contiguous axial MR scans. Five cases were confirmed by operation. The prevalence of the corner, fat crescent, and parallel signs were 12 out of 12 (100%), 6 out of 12 (50%), and 8 out of 12 (67.7%) on axial T1-weighted images. The overall diagnostic confidence was higher on T1- than on T2-weighted images (P < 0.05). On routine axial L-spine MRI, corner, fat crescent, and parallel signs are suggestive of and assist in the recognition of a conjoined nerve root. (orig.)

  1. Does the Rotator Cuff Tear Pattern Influence Clinical Outcomes After Surgical Repair?

    Science.gov (United States)

    Watson, Scott; Allen, Benjamin; Robbins, Chris; Bedi, Asheesh; Gagnier, Joel J; Miller, Bruce

    2018-03-01

    Limited literature exists regarding the influence of rotator cuff tear morphology on patient outcomes. To determine the effect of rotator cuff tear pattern (crescent, U-shape, L-shape) on patient-reported outcomes after rotator cuff repair. Cohort study; Level of evidence, 3. Patients undergoing arthroscopic repair of known full-thickness rotator cuff tears were observed prospectively at regular intervals from baseline to 1 year. The tear pattern was classified at the time of surgery as crescent, U-shaped, or L-shaped. Primary outcome measures were the Western Ontario Rotator Cuff Index (WORC), the American Shoulder and Elbow Surgeons (ASES), and a visual analog scale (VAS) for pain. The tear pattern was evaluated as the primary predictor while controlling for variables known to affect rotator cuff outcomes. Mixed-methods regression and analysis of variance (ANOVA) were used to examine the effects of tear morphology on patient-reported outcomes after surgical repair from baseline to 1 year. A total of 82 patients were included in the study (53 male, 29 female; mean age, 58 years [range, 41-75 years]). A crescent shape was the most common tear pattern (54%), followed by U-shaped (25%) and L-shaped tears (21%). There were no significant differences in outcome scores between the 3 groups at baseline. All 3 groups showed statistically significant improvement from baseline to 1 year, but analysis failed to show any predictive effect in the change in outcome scores from baseline to 1 year for the WORC, ASES, or VAS when tear pattern was the primary predictor. Further ANOVA also failed to show any significant difference in the change in outcome scores from baseline to 1 year for the WORC ( P = .96), ASES ( P = .71), or VAS ( P = .86). Rotator cuff tear pattern is not a predictor of functional outcomes after arthroscopic rotator cuff repair.

  2. HBV, HCV and HIV seroprevalence among blood donors in Istanbul, Turkey: how effective are the changes in the national blood transfusion policies?

    Directory of Open Access Journals (Sweden)

    Ali Acar

    Full Text Available The national blood transfusion policies have been changed significantly in recent years in Turkey. The purpose of this study was to determine the prevalence of HBV, HCV, and HIV in blood donors at the Red Crescent Center in Istanbul and to evaluate the effect of changes in the national blood transfusion policies on the prevalence of these infections. The screening results of 72695 blood donations at the Red Crescent Center in Istanbul between January and December 2007 were evaluated retrospectively. HBsAg, anti-HCV, and anti-HIV-1/2 were screened by microparticle enzyme immunoassay (MEIA method. Samples found to be positive for anti-HIV 1/2 and anti-HCV were confirmed by Inno-Lia HCV Ab III and Inno-Lia HIV I/II Score, respectively. The seropositivity rates for HBsAg, anti-HCV, and anti-HIV-1/2 were determined as 1.76%, 0.07%, and 0.008%, respectively. Compared to the previously published data from Red Crescent Centers in Turkey, it was found that HBV and HCV seroprevalances decreased and HIV seroprevalance increased in recent years. In conclusion, we believe that the drop in HBV and HCV prevalence rates are likely multifactorial and may have resulted from more diligent donor questioning upon screening, a higher level of public awareness on viral hepatitis as well as the expansion of HBV vaccination coverage in Turkey. Another factor to contribute to the decreased prevalence of HCV stems from the use of more sensitive confirmation testing on all reactive results, thereby eliminating a fair amount of false positive cases. Despite similar transmission routes, the increase in HIV prevalence in contrast to HBV and HCV may be linked to the increase in AIDS cases in Turkey in recent years.

  3. Development of spatially diverse and complex dune-field patterns: Gran Desierto Dune Field, Sonora, Mexico

    Science.gov (United States)

    Beveridge, C.; Kocurek, G.; Ewing, R.C.; Lancaster, N.; Morthekai, P.; Singhvi, A.K.; Mahan, S.A.

    2006-01-01

    The pattern of dunes within the Gran Desierto of Sonora, Mexico, is both spatially diverse and complex. Identification of the pattern components from remote-sensing images, combined with statistical analysis of their measured parameters demonstrate that the composite pattern consists of separate populations of simple dune patterns. Age-bracketing by optically stimulated luminescence (OSL) indicates that the simple patterns represent relatively short-lived aeolian constructional events since ???25 ka. The simple dune patterns consist of: (i) late Pleistocene relict linear dunes; (ii) degraded crescentic dunes formed at ???12 ka; (iii) early Holocene western crescentic dunes; (iv) eastern crescentic dunes emplaced at ???7 ka; and (v) star dunes formed during the last 3 ka. Recognition of the simple patterns and their ages allows for the geomorphic backstripping of the composite pattern. Palaeowind reconstructions, based upon the rule of gross bedform-normal transport, are largely in agreement with regional proxy data. The sediment state over time for the Gran Desierto is one in which the sediment supply for aeolian constructional events is derived from previously stored sediment (Ancestral Colorado River sediment), and contemporaneous influx from the lower Colorado River valley and coastal influx from the Bahia del Adair inlet. Aeolian constructional events are triggered by climatic shifts to greater aridity, changes in the wind regime, and the development of a sediment supply. The rate of geomorphic change within the Gran Desierto is significantly greater than the rate of subsidence and burial of the accumulation surface upon which it rests. ?? 2006 The Authors. Journal compilation 2006 International Association of Sedimentologists.

  4. Fatty rind of intramuscular soft-tissue tumors of the extremity: is it different from the split fat sign?

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Jinkyeong; Kim, Jee-Young [The Catholic University of Korea, Departments of Radiology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of)

    2017-05-15

    To analyze intramuscular soft-tissue tumors with fatty rind, and to evaluate the difference between fatty rind and split fat sign on magnetic resonance imaging (MRI). We retrospectively analyzed 50 pathologically confirmed intramuscular masses on MRI. We evaluated the distribution and shape of fatty rind and muscle atrophy. Fatty rind was found more frequently in benign lesions (80% [36 out of 45]) compared with malignant lesions (25% [1 out of 5]; P = 0.013). Thirty-six benign lesions were peripheral nerve sheath tumors (PNSTs; n = 19), hemangiomas (n = 11), myxomas (n = 2), ganglion cysts (n = 2), giant cell tumor (n = 1), and leiomyoma (n = 1). One malignant lesion was a low-grade fibromyxoid sarcoma. In all masses with fatty rind, fat was confined to the proximal and the distal ends. In 12 cases, complete or partial circumferential fatty rind was also noted. Fatty rinds at both ends showed crescent, triangular, or combined shape. The prevalence of crescent-shaped fatty rind was significantly higher in benign PNST (17 out of 38) compared with the other tumors (1 out of 32; P < 0.001). Complete circumferential fat was noted only in hemangioma (n = 5). Triangular fatty rind was related to peripheral location of the mass or muscle atrophy. Most intramuscular tumors with fatty rinds were benign, and PNST was the most common tumor type. Fatty rind could be caused by displaced neurovascular bundle fat, fatty atrophy of the muscle involved, or intermuscular or perimysial fat. Crescent-shaped fatty rind was noted more frequently in benign PNSTs. (orig.)

  5. Fatty rind of intramuscular soft-tissue tumors of the extremity: is it different from the split fat sign?

    International Nuclear Information System (INIS)

    Sung, Jinkyeong; Kim, Jee-Young

    2017-01-01

    To analyze intramuscular soft-tissue tumors with fatty rind, and to evaluate the difference between fatty rind and split fat sign on magnetic resonance imaging (MRI). We retrospectively analyzed 50 pathologically confirmed intramuscular masses on MRI. We evaluated the distribution and shape of fatty rind and muscle atrophy. Fatty rind was found more frequently in benign lesions (80% [36 out of 45]) compared with malignant lesions (25% [1 out of 5]; P = 0.013). Thirty-six benign lesions were peripheral nerve sheath tumors (PNSTs; n = 19), hemangiomas (n = 11), myxomas (n = 2), ganglion cysts (n = 2), giant cell tumor (n = 1), and leiomyoma (n = 1). One malignant lesion was a low-grade fibromyxoid sarcoma. In all masses with fatty rind, fat was confined to the proximal and the distal ends. In 12 cases, complete or partial circumferential fatty rind was also noted. Fatty rinds at both ends showed crescent, triangular, or combined shape. The prevalence of crescent-shaped fatty rind was significantly higher in benign PNST (17 out of 38) compared with the other tumors (1 out of 32; P < 0.001). Complete circumferential fat was noted only in hemangioma (n = 5). Triangular fatty rind was related to peripheral location of the mass or muscle atrophy. Most intramuscular tumors with fatty rinds were benign, and PNST was the most common tumor type. Fatty rind could be caused by displaced neurovascular bundle fat, fatty atrophy of the muscle involved, or intermuscular or perimysial fat. Crescent-shaped fatty rind was noted more frequently in benign PNSTs. (orig.)

  6. Usina fotovoltaica de 1 MWp para suprimento de veículos elétricos : estimativa da frota atendida, logística de abastecimento e emissões de CO2 evitadas

    OpenAIRE

    Karina Maretti Strangueto

    2012-01-01

    Resumo: Desde a Revolução Industrial, as atividades desenvolvidas pelo homem têm provocado um crescimento maciço das emissões de gases de efeito estufa e poluentes para a atmosfera da Terra, devido, entre outros fatores, à constante e crescente necessidade de energia. Um grande esforço vem sendo realizado nas últimas décadas para a redução dessas emissões, com especial atenção ao setor de transporte, principalmente pelos efeitos provocados nas populações das grandes cidades devido à concentra...

  7. Projeto de implementação do processo Sales and Operations Planning (S&OP) - caso de estudo

    OpenAIRE

    Lima, Daniela Alexandra de Sousa

    2017-01-01

    Apesar de o conceito de Sales and Operations Planning (S&OP) ter sido introduzido há já algumas décadas, este tem ganho um reconhecimento acrescido, uma vez que a incerteza dos mercados e a crescente complexidade das supply chains aumentam a necessidade de determinar ações futuras e criar um plano de vendas e operações comum. S&OP é um processo multifuncional que promove o desenvolvimento e a aceitação de um plano comum, permitindo o alinhamento entre a oferta e a procura, conecta o planeamen...

  8. Proposta de indicadores para avaliação de desempenho dos Sistemas de Gestão Ambiental e de Segurança e Saúde no Trabalho de Empresas do ramo de engenharia consultiva

    OpenAIRE

    Clarissa Lima Almeida; Ana Bárbara de Araújo Nunes

    2014-01-01

    O processo de implantação de um sistema de gestão agrega valor à cultura organizacional, pois desenvolve competências relacionadas ao planejamento e execução das atividades, prioriza a capacidade de trabalho em equipe e promove a confiabilidade do sistema produtivo. Deste modo, uma das principais ferramentas utilizadas na política econômica das organizações tem sido a implementação de um Sistema de Gestão Ambiental (SGA). Do mesmo modo, o crescente número de acidentes repercutidos na mídia fe...

  9. Estilos parentais e práticas educativas parentais: revisão sistemática e crítica da literatura

    OpenAIRE

    Cynthia Cassoni

    2013-01-01

    Introdução: As mudanças nas relações entre pais e filhos decorrentes das transformações pelas quais a família vem passando têm levado a um crescente questionamento sobre o papel dos pais na educação de seus filhos. Objetivo: Realizar um levantamento sistemático e revisão crítica da literatura referente a estilos e práticas parentais, buscando apontar diretrizes que possam ser orientadores para pesquisadores, profissionais e pais. Metodologia: Revisão sistemática integrativa da literatura. Def...

  10. Em torno da cidade criativa

    Directory of Open Access Journals (Sweden)

    Paulo Peixoto

    2013-09-01

    Full Text Available A mudança do milénio trouxe consigo a importância crescente das indústrias ancoradas na cultura e na criatividade. Este facto alimentou um desejo internacional – que, na verdade, é recorrentemente encarado como um imperativo incontornável – que motiva as áreas urbanas a quererem tornar se “cidades criativas”. A própria UNESCO fomentou este fenómeno ao criar a Rede das Cidades Criativas. Nas cidades criativas, conceito que emergiu e se consolidou a partir dos anos 1980, as atividades culturais...

  11. A soft X-ray image of the Moon

    International Nuclear Information System (INIS)

    Schmitt, J.H.M.M.; Aschenbach, B.; Hasinger, G.; Pfeffermann, E.; Predehl, P.; Truemper, J.; Snowden, S.L.; Wisconsin Univ., Madison, WI

    1991-01-01

    A soft X-ray image of the Moon obtained by the Roentgen Observatory Satellite ROSAT clearly shows a sunlit crescent, demonstrating that the Moon's X-ray luminosity arises from backscattering of solar X-rays. The Moon's optically dark side is also X-ray dark, and casts a distinct shadow on the diffuse cosmic X-ray background. Unexpectedly, the dark side seems to emit X-rays at a level about one per cent that of the bright side; this emission very probably results from energetic solar-wind electrons striking the Moon's surface. (author)

  12. A família nas políticas sociais: o caso do Programa Bolsa Família

    OpenAIRE

    Marcelo Couto Dias

    2013-01-01

    Nos países ocidentais, os últimos anos têm sido marcados por uma crescente redescoberta do valor da família e das microssolidariedades. Prova disso é o aparecimento da família tanto nas discussões das políticas sociais, quanto nos processos de formulação das mesmas. No contexto brasileiro recente, ganhou destaque a criação e expansão do Bolsa Família, um programa de transferência direta de renda com condicionalidades que, em 2012, tinha entre os seus beneficiários mais de 13 mi...

  13. Características individuais associadas à autopercepção da extensão territorial da vizinhança

    OpenAIRE

    Célio, Fabiano de Almeida; Xavier, Cesar Coelho; Andrade, Amanda Cristina de Souza; Camargos, Vitor Passos; Caiaffa, Waleska Teixeira; Friche, Amélia Augusta de Lima; Cortês, Marcela Guimarães; Proietti, Fernando Augusto

    2014-01-01

    É crescente o interesse em investigar os impactos da vizinhança na saúde. Para definir vizinhança, duas estratégias principais são encontradas: uma utiliza fronteiras artificiais criadas para finalidades administrativas, a outra considera a definição do indivíduo, vizinhança autopercebida. O objetivo deste estudo foi identificar os fatores associados à heterogeneidade da autopercepção da dimensão territorial da vizinhança entre os participantes de um inquérito de saúde em Belo Horizonte, Mina...

  14. Polpação de palha de milho, utilizando-se diferentes processos organosolv

    OpenAIRE

    Maria Lucia Bianchi

    1995-01-01

    Resumo: A disponibilidade de palha de milho e a crescente procura de matérias primas alternativas que substituam a madeira na fabricação de papel, levaram à investigação da possibilidade de polpação da palha de milho, utilizando-se diferentes processos Organosolv. A palha de milho foi analisada, apresentando cerca de 13% de umidade, 1% de cinzas, 7% de extrativos, 24% de lignina Klason, 54% de celulose e 16% de polioses (por diferença), com um total de 71% de holocelulose. A análise elementar...

  15. Allanças de marca. por que, como e quando?

    OpenAIRE

    Marin, Longinos; Rubio, Alicia

    2012-01-01

    Nos ultimos anos, as atividades de aliança de marta tiveram um crescente protagonismo no lançamento de novos produtos por parte das empresas. Nao obstante, existem poucos trabalhos que analisem de forma integral a justificaçao par parte das empresas sobre esta estrategia. O presente trabalho analisa as teorias que justificam porque e em que cenarios devem ser utilizadas as alianças de marca desde a perspectiva do comportamento do consumidor. O artigo tambem aprofunda nas condiçoes enos cenari...

  16. Uso da Canavalia ensiformis como fitorremediador de solos contaminados por chumbo

    OpenAIRE

    Mazzuco, Kátia Teresinha Mateus

    2008-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Química. Atualmente setores de várias áreas têm observado com grande interesse o crescente número de poluentes existentes em todo o mundo. Por esse motivo aumenta o interesse por técnicas remediadoras, tendo neste momento um foco maior o solo. Varias técnicas são estudadas e a fitorremediação possui um lugar de destaque devido à sua eficiência na descontaminação dos solos ...

  17. “Viver positivamente”: as lições ensinadas por peças publicitárias da Coca-Cola Company

    Directory of Open Access Journals (Sweden)

    Daniela Ripoll

    2014-08-01

    Full Text Available Analisa-se a campanha publicitária da Coca-Cola Company Brasil, “Viva positivamente!”. A partir dos Estudos Culturais, dos Estudos de Mídia e das discussões pós-modernas acerca do consumo do corpo e de determinados estilos de vida na mídia, discute-se o crescente movimento de “redenção” ou, ainda, de “absolvição” do consumo, construído pedagógica e culturalmente como algo positivo e relacionado à melhora do corpo e da qualidade de vida dos sujeitos na contemporaneidade.

  18. SOLOS GERADOS A PARTIR DO INTEMPERISMO DE CROSTAS LATERÍTICAS SÍLICO-FERRUGINOSAS

    OpenAIRE

    HORBE, Adriana Maria Coimbra; COSTA, Marcondes Lima da

    1997-01-01

    A porção superior de dois perfis lateriticos localizados nos balneáreos de Outeiro e Mosqueiro, no município de Belém (Pará-Brasil), é constituída pela crosta sílico-ferruginosa e seus fragmentos de crosta, com material areno-argiloso sobreposto formando o solo. A estrutura colunar preservada, o grau de arredondamento crescente dos fragmentos e a composição mineralógica e química demonstram que há uma passagem gradacional entre a crosta, fragmentos e o solo dos dois perfis. Assim, é possível ...

  19. O e-mail como ferramenta de marketing: uma revisão da literatura

    OpenAIRE

    Fortes, Nuno; Rita, Paulo

    2004-01-01

    Este artigo, assente exclusivamente em revisão bibliográfica, pretende apresentar as potencialidades do e-mail como uma ferramenta de comunicação de marketing. Em virtude do universo do e-mail marketing estar ensombrado por um crescente fenómeno de spam, são apresentadas duas abordagens alternativas, mas complementares - o marketing de permissão e o marketing viral-, capazes de manterem em níveis elevados os indicadores de eficácia das campanhas.

  20. Marketing digital e marketing de relacionamento: interação e engajamento como determinantes do crescimento de páginas do Facebook

    OpenAIRE

    Felipe Ribeiro Soares; Plínio Rafael Reis Monteiro

    2015-01-01

    As transformações deflagradas pela internet, permitindo a aproximação de clientes e fornecedores, têm gerado crescentes reflexões acadêmicas e empresariais que culminam na proposição do uso de mídias sociais como ferramentas de marketing. Nesse sentido, este estudo buscou verificar o impacto das ações realizadas pela organização nas redes sociais relativamente às interações e ao engajamento de usuários, e seus reflexos para o crescimento da popularidade da marca no ambiente virtual. Tomando c...

  1. Primary signet cell adenocarcinoma of bladder

    Directory of Open Access Journals (Sweden)

    Prateek Kinra

    2017-01-01

    Full Text Available Primary signet cell cancer of the urinary bladder is a relatively rare entity. Since there is no mucinous epithelium in the bladder, It is proposed that the tumor arises from metaplastic urothelium. Two thirds of the tumours are mucin secreting, in most of which the site of the deposition is either extracellular or intracellular displacing the nucleus to a peripheral crescent, giving the cells a signet ring appearance. The tumours are most often infiltrative and diffusely involving the majority of the bladder akin to its name sake in stomach. It is essential to distinguish this carcinoma from gastrointestinal metastases as different therapeutic strategies are often necessary.

  2. [Classification and Treatment of Sacroiliac Joint Dislocation].

    Science.gov (United States)

    Tan, Zhen; Huang, Zhong; Li, Liang; Meng, Wei-Kun; Liu, Lei; Zhang, Hui; Wang, Guang-Lin; Huang, Fu-Guo

    2017-09-01

    To develop a renewed classification and treatment regimen for sacroiliac joint dislocation. According to the direction of dislocation of sacroiliac joint,combined iliac,sacral fractures,and fracture morphology,sacroiliac joint dislocation was classified into 4 types. Type Ⅰ (sacroiliac anterior dislocation): main fracture fragments of posterior iliac wing dislocated in front of sacroiliac joint. Type Ⅱ (sacroiliac posterior dislocation): main fracture fragments of posterior iliac wing dislocated in posterior of sacroiliac joint. Type Ⅲ (Crescent fracturedislocation of the sacroiliac joint): upward dislocation of posterior iliac wing with oblique fracture through posterior iliac wing. Type ⅢA: a large crescent fragment and dislocation comprises no more than onethird of sacroiliac joint,which is typically inferior. Type ⅢB: intermediatesize crescent fragment and dislocation comprises between one and twothirds of joint. Type ⅢC: a small crescent fragment where dislocation comprises most,but not the entire joint. Different treatment regimens were selected for different types of fractures. Treatment for type Ⅰ sacroiliac joint dislocation: anterior iliac fossa approach pry stripping reset; sacroiliac joint fixed with sacroiliac screw through percutaneous. Treatment for type Ⅱ sacroiliac joint dislocation: posterior sacroiliac joint posterior approach; sacroiliac joint fixed with sacroiliac screw under computer guidance. Treatment for type ⅢA and ⅢB sacroiliac joint dislocation: posterior sacroiliac joint approach; sacroiliac joint fixed with reconstruction plate. Treatment for type ⅢC sacroiliac joint dislocation: sacroiliac joint closed reduction; sacroiliac joint fixed with sacroiliac screw through percutaneous. Treatment for type Ⅳ sacroiliac joint dislocation: posterior approach; sacroiliac joint fixed with spinal pelvic fixation. Results of 24 to 72 months patient follow-up (mean 34.5 months): 100% survival,100% wound healing,and 100

  3. Diferenças de género no conflito trabalho-família: um estudo com famílias portuguesas de duplo-emprego com filhos em idade pré-escolar

    OpenAIRE

    Matias, Marisa; Andrade, Cláudia; Fontaine, Anne Marie

    2011-01-01

    Portugal apresenta uma crescente participação feminina no mercado de trabalho, levando a que o modelo familiar de um único elemento a trabalhar fora de casa tenha perdido expressão. Actualmente, as famílias de duplo-emprego ultrapassam em número as famílias com um único emprego, pelo que homens e mulheres debatem-se com as novas exigências do seu trabalho e da sua família. Assim, as responsabilidades do trabalho profissional, tarefas domésticas e cuidado dos filhos não se confinam mais à divi...

  4. Análise de um sistema de captura de energia piezoelétrico não linear e não ideal utilizando-se uma estrutura aporticada.

    OpenAIRE

    Itamar Iliuk

    2016-01-01

    A crescente utilização de novas tecnologias, as quais necessitam de uma fonte de energia menor e mais eficiente, como os microssensores para monitoramento de sistemas e estruturas nas chamadas cidades inteligentes, torna a captura da energia do ambiente uma opção viável para alimentação de tais dispositivos. Como a energia cinética é uma fonte de energia facilmente encontrada no ambiente, os sistemas que a capturam e convertem em eletricidade têm sido amplamente estudados, especialmente os qu...

  5. Análise da durabilidade de compósitos cimentícios de elevada capacidade de deformação reforçados com fibras

    OpenAIRE

    Fernanda Bianchi Pereira da Costa

    2015-01-01

    Apesar do avanço tecnológico crescente na construção civil, a falta de durabilidade das estruturas de concreto, tanto em edificações como pavimentação, tem sido constatada com acentuada assiduidade e proporção. O compósito cimentício de elevada deformação, também conhecido como Engineered Cementitious Composites (ECC), foi difundido a partir do conceito de concretos de alto desempenho reforçado com fibras, visando suprir o comportamento frágil do concreto convencional e problemas relacionados...

  6. Controle Externo da governança de Tecnologia da Informação

    OpenAIRE

    Raimir Holanda Filho; José Auriço Oliveira

    2012-01-01

    O crescente processo de informatização da Administração Pública brasileira contribui para uma maior agilidade e qualidade nos serviços públicos prestados para a sociedade e um consequente aumento na transparência das ações governamentais. Por outro lado, os gastos nos investimentos e na manutenção dos recursos de Tecnologia da Informação (TI) vêm aumentando consideravelmente, bem como tem-se verificado uma forte dependência das instituições com relação aos sistemas informatizados e à seguranç...

  7. Squalius namak, a new chub from Lake Namak basin in Iran (Teleostei: Cyprinidae).

    Science.gov (United States)

    Khaefi, Roozbehan; Esmaeili, Hamid Reza; Sayyadzadeh, Golnaz; Geiger, Matthias F; Freyhof, Jörg

    2016-09-19

    Squalius namak, new species, from the endorheic Lake Namak and Kavir basins in Iran, is distinguished from the species of the genus Squalius in the Persian Gulf and the southern Caspian Sea basins by having a wide and thick symphysial knob on the lower jaw, a convex posterior anal-fin margin, a bold, dark-grey or brown, roundish or crescent-shaped blotch at the posterior tip of each flank scale and orange caudal-, anal- and pelvic-fin rays in life. Squalius namak is also characterized by four fixed, diagnostic nucleotide substitutions in the mtDNA COI barcode region.

  8. Análise de uma iniciativa de valorização de rios e lagoas em áreas urbanas: Programa Águas do rio (Guardiões dos rios).

    OpenAIRE

    Andreia Cardoso da Silva

    2009-01-01

    A preocupação com recursos hídricos tem sido crescente em meios urbanos. O despejo de resíduos sólidos em rios é comum por populações ribeirinhas, favorecendo a ocorrência de enchentes, a proliferação de vetores e doenças e o desprezo da comunidade pelos rios. Nesse contexto, programas que relacionam lixo, recursos hídricos e população ribeirinha têm sido objeto de várias iniciativas governamentais. Este trabalho busca avaliar uma delas: o Programa Municipal de valorização de r...

  9. Objeto de desejo e estratégia de marketing: um estudo do valor de uso da natureza na publicidade televisiva de dois canais portugueses

    OpenAIRE

    Santos, Isabel Cristina Vaz

    2014-01-01

    Dissertação de Mestrado, Gestão e Conservação da Natureza, 12 de Junho de 2014, Universidade dos Açores. Assiste-se actualmente a uma visibilidade crescente dos problemas ambientais, da mesma forma que as problemáticas da sustentabilidade e da protecção da biodiversidade começam a afirmar-se nas agendas políticas nacionais e internacionais. Mas que papel têm desempenhado os media nesta consciencialização ambiental? A audibilidade conquistada pelos media junto da generalidade dos portuguese...

  10. Asian gardens: history, beliefs and design

    OpenAIRE

    Turner, Tom

    2010-01-01

    [Book description from publisher's website]\\ud The gardens made on the fringes of Central Asia in the past 5000 years form a great arc. From the Fertile Crescent, it runs west to Europe and east to China and Japan. Asia's fringe was a zone of interchange: a vast landscape in which herders encountered farmers and the design of symbolic gardens began. It appears that as they became settlers, nomads retained a love of mobility, hunting and the wild places in which their ancestors had roamed. Cen...

  11. Potencial anti-Sporothrix spp. de plantas da família lamiaceae

    OpenAIRE

    Stefanie Bressan Waller

    2015-01-01

    As propriedades terapêuticas das plantas medicinais são cada vez mais estudadas, principalmente devido aos crescentes casos de resistência antimicrobiana, como observado em cepas do Complexo Sporothrix. As plantas da família Lamiaceae são conhecidas por suas propriedades antifúngicas, entretanto, são escassos seus estudos contra agentes causadores da esporotricose. Devido ao potencial promissor dessas plantas, objetivou-se (1) avaliar a atividade anti-Sporothrix spp. in vitro de Origanum vulg...

  12. Michel Foucault e a revolução narrativa em psicopatologia e psicoterapia: ser-em-estórias entre pathos e poiesis

    Directory of Open Access Journals (Sweden)

    Paulo Jesus

    Full Text Available O modelo narrativo em psicopatologia e psicoterapia, com dinamismo crescente desde a proposta inicial de White e Epston (1990, afirma-se como crítica “discursiva” não somente das categorias de diagnóstico psicopatológico, mas também da assimetria cognitiva e prática na relação psicoterapêutica. Neste artigo, examinamos os fundamentos epistemológicos desse modelo, recorrendo a Michel Foucault para examinar os processos simbólicos de criação narrativa da subjetividade.

  13. O pilar que ficou: um estudo de conservação em bens patrimoniais a partir do conceito de valor: o caso da Igreja do Pilar do Recife

    OpenAIRE

    Bernardi Della Giustina, Lêda

    2010-01-01

    A crescente busca de reinserção de bens patrimoniais, que estão em desuso ou foram abandonados, nos contextos urbanos atuais, mostra o conflito inerente ao processo de mudança e adaptação de valores. Para discutir essa questão o estudo aqui apresentado, tem como objetivo refletir sobre a conservação de um bem patrimonial religioso em estado de degradação, considerando-se sua desvinculação com o atual contexto descaracterizado em que está inserido. Para tal, pesquisa-se a Igreja...

  14. Propaganda negativa nas eleições presidenciais brasileiras

    OpenAIRE

    Borba, Felipe

    2015-01-01

    ResumoEste artigo tem como propósito investigar a propaganda negativa nas eleições presidenciais brasileiras. Tema de extrema relevância tendo em vista que a literatura recente vem sugerindo que o tom das campanhas tem consequências importantes para a decisão do voto, a participação política e o nível de informação dos eleitores. Entretanto, a maior parte desses estudos foi realizada para entender a realidade política dos Estados Unidos. No Brasil, apesar do crescente interesse pelos efeitos ...

  15. Energia e sustentabilidade: desafios do Brasil na expansão da oferta e na gestão da demanda

    OpenAIRE

    Hollanda, Lavínia; Varejão, Mônica

    2014-01-01

    Esse caderno é fruto de uma parceria entre a FGV Energia e a Catavento, que somaram esforços no intuito de estimular um novo olhar sobre os dilemas enfrentados no setor de energia no Brasil. Alimentar o debate em torno de questões primordiais, que afetam tanto as possibilidades de expansão das fontes de energia, quanto o papel da demanda, em um contexto de uso eficiente de recursos naturais e restrições crescentes às emissões de gases de efeito estufa, é a premissa desse trabal...

  16. Collection for Refugiees

    CERN Multimedia

    Staff Association

    2015-01-01

    You are wonderful, thank you! In response to the refugee and migration crisis, we organised a collection in October and November which called on your generosity. We are now pleased to announce that the amount raised is CHF 14'710. These funds will be forwarded to the International Federation of Red Cross and Red Crescent Societies to respond to the humanitarian needs of the refugees and migrants, providing immediate and longer-term relief, including emergency medical care and basic health services, psychological support, temporary shelter, distribution of food & water and other urgently needed items. We thank everyone who contributed to this important cause.

  17. Microfranchise e Background in São Paulo City

    OpenAIRE

    Cardoso, Sarah Ribeiro; Melo, Pedro Lucas de Resende; de Souza, Leandro Januario

    2016-01-01

    O modelo de microfranquia é recente dentro do sistema de franchising, tem como característica principal o baixo investimento inicial. Atualmente vem se destacando no mercado brasileiro, junto às pessoas da classe emergente, que buscam ter seu próprio negócio. É crescente o número de pessoas que escolhem empregar recursos financeiros para gerir um negócio, cuja marca e estrutura gerencial esteja pronta. Assim, nosso objetivo foi identificar o background dos microfranqueados a fim de analisar s...

  18. PRODUCT VARIETY MANAGEMENT IN AUTOMOTIVE INDUSTRY WORLDWIDE

    OpenAIRE

    AUGUSTO DA CUNHA REIS

    2009-01-01

    A proliferação da variedade de produtos é uma tendência em diferentes indústrias e se constitui em um assunto com crescente relevância para o mundo empresarial e acadêmico. A gestão dessa variedade deve buscar equilibrar os benefícios oriundos da perspectiva do marketing com os efeitos negativos provocados, em geral, pela perspectiva de operações e logística. Assim, tal gestão se torna um grande desafio para indústrias em que a v...

  19. Carnes PSE (pale, soft, exudative) e análogo ao DFD (dark, firm, dry) de frango em embutido cárneos

    OpenAIRE

    Daryne Lu Maldonado Gomes da Costa

    2008-01-01

    O crescente consumo mundial de carne de frango e produtos processados, fez aumentar a preocupação com a qualidade da carne fresca, consequentemente anormalidades relacionadas a cor, como o PSE (Pale, Soft, Exudative) e análogo ao DFD (Dark, Firm, Dry) ganharam a sua devida importância. O objetivo deste trabalho foi investigar a influência da utilização de carnes PSE e análogo ao DFD (a-DFD) como matéria-prima para elaboração de embutidos cárneos. Os filés foram coletados e analisados 24h post...

  20. CAUSAS DE MORTE E RAZÕES PARA EUTANÁSIA DE CÃES

    OpenAIRE

    Rafael Almeida Fighera

    2008-01-01

    A crescente aproximação afetiva entre os cães e o homem fez com que nos últimos anos fosse gerada muita informação científica sobre medicina canina. Entretanto, como a maior parte dessas informações é obtida através da literatura internacional, é comum que os clínicos e patologistas veterinários brasileiros necessitem extrapolar dados referentes à prevalência das diferentes doenças que causam morte de cães para nossa realidade. Baseado nisso, este estudo tem como objetivo principal dete...

  1. FTM, transhomem, homem trans, trans, homem

    OpenAIRE

    Ávila, Simone Nunes

    2014-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação Interdisciplinar em Ciências Humanas, Florianópolis, 2014. Desde 2010 é possível perceber a crescente visibilidade de transhomens no Brasil, tanto na mídia quanto no movimento de Lésbicas, Gays, Bissexuais, Travestis e Transexuais (LGBT). O tema central desta tese é a emergência de masculinidades produzidas por transhomens, as transmasculinidades, que vêm se constitu...

  2. Proposta de um processo de gestão da manutenção para a área de utilidades e projetos da Pilkington Brasil Ltda.

    OpenAIRE

    Etienne Cursino Ortiz

    2006-01-01

    A necessidade de evolução das empresas para enfrentar desafios cada vez maiores, exige, entre outras ações, o aperfeiçoamento de técnicas e sistemas de gerenciamento da manutenção, que é o foco deste trabalho. A constatação da necessidade de implementação de um sistema de gerenciamento mais adequado na manutenção ocorreu em função da crescente demanda por serviços e ao aumento das ocorrências emergenciais da planta que vinham comprometendo as atividades do setor, principalmente em aspectos co...

  3. Cola, plágio e outras práticas acadêmicas desonestas: um estudo quantitativo-descritivo sobre o comportamento de alunos de graduação e pós-graduação da área de negócios

    OpenAIRE

    Veludo-de-Oliveira,Tânia Modesto; Aguiar,Fernando Henrique Oliveira de; Queiroz,Josimeire Pessoa de; Barrichello,Alcides

    2014-01-01

    As atividades fraudulentas no mundo corporativo têm sido motivo crescente de preocupação da sociedade e podem estar associadas a falhas na formação educacional dos gestores. Este estudo tem por objetivo analisar o comportamento dos alunos de cursos relacionados à área de negócios no que tange a práticas acadêmicas desonestas, como cola e plágio; a base teórica adotada para o desenvolvimento da pesquisa foi o trabalho de Chapman, Davis, Toy e Wright (2004). O escopo teórico do estudo versa sob...

  4. A interação entre o controle de processos e a metrologia em indústrias de manufatura

    OpenAIRE

    Baldo, Crhistian Raffaelo

    2003-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Metrologia Científica e Industrial. A competitividade característica do mercado globalizado exige das empresas significativos esforços para produzir com qualidade crescente a custos compatíveis, tendo como objetivo final satisfazer as necessidades dos clientes. Para que essa condição seja satisfeita, é necessário que as ações sejam intensificadas nas fases de concepção e planej...

  5. "APONTAMENTOS SOBRE A POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS, INSTITUÍDA PELA LEI FEDERAL N° 12.305, DE 02.08.2010"

    OpenAIRE

    Rauber, Marcos Eduardo

    2011-01-01

    http://dx.doi.org/10.5902/223611703893 http://dx.doi.org/10.5902/223611703893O vertiginoso crescimento demográfico experimentado pela humanidade no último século, associada à urbanização desordenada e ao desenvolvimento extraordinário da indústria e do mercado de consumo desde a Revolução Industrial, tem trazido grandes desafios aos governos e à coletividade. Um deles, sem dúvida, é a destinação do crescente volume e variedades de resíduos e rejeitos gerados pela produção, comercialização ...

  6. Afecções cirúrgicas em aves: estudo retrospectivo

    OpenAIRE

    Patricia Ferreira de Castro

    2010-01-01

    As aves representam a grande maioria das espécies da fauna silvestre mantidas como animais de companhia em nosso meio e respondem diretamente pela crescente demanda pelo atendimento médico veterinário. O avanço na área da anestesiologia viabilizou a realização de procedimentos cirúrgicos mais longos e complexos e contribuiu para o desenvolvimento e aprimoramento da técnica operatória em aves, contudo, dados nacionais de casuística relacionados às afecções cirúrgicas de aves ainda são inexiste...

  7. Gestão da qualidade nos frigoríficos de abate e processamento de frangos no estado de Mato Grosso do Sul

    OpenAIRE

    Bueno, Miriam Pinheiro

    2006-01-01

    O mercado de carnes no Brasil e no mundo está cada vez mais competitivo e complexo. Essa complexidade é resultante sobretudo do ciclo de vida e do grau de perecibilidade do produto, das exigencias de rigorosos controles sanitários e da crescente demanda por diversificação e agregação de valor, mesmo no caso de um mercado cujo principal produto é, em essencia, uma commodity (PEREIRA, 2003). Dentre os critérios exigidos pelo mercado consumidor de alimentos, a variável risco à saúde humana tem m...

  8. The effects of bone erosion from aortic aneurysm on the regional uptake of FDG

    DEFF Research Database (Denmark)

    Louring-Andersen, J.; Law, I.

    2008-01-01

    aorta just below the carina. An abnormal crescent-shaped uptake was identified at the margin between the aneurysm and the adjacent thoracic vertebral bodies. At this site a correspondingly shaped bone erosion on CT was proof of the chronic effects of the aneurysm. There were no signs of regional......A 71-year-old white man with a known right-sided apical nonsmall cell lung carcinoma was referred for a F-18 FDG whole body PET-CT examination after chemotherapy before radiotherapy. A staging CT scan had revealed an asymptomatic fusiform 65 mm in diameter nondissecting aneurysm of the thoracic...

  9. Morte encefálica, cuidados ao doador de órgãos e transplante de pulmão

    OpenAIRE

    D'Império,Fernando

    2007-01-01

    JUSTIFICATIVA E OBJETIVOS: O transplante de órgãos é aceito como uma opção para doença orgânica terminal, em pacientes bem selecionados. Este é o resultado de grandes avanços nos campos da Imunologia, da Tecnologia da Terapia Intensiva e da Farmacologia. Entretanto, os sistemas de transplantes são, atualmente, vítimas de seu próprio sucesso, à medida que as listas de espera se alongam, em contraste com a disponibilidade de órgãos, que permanece estável, acarretando crescente número de mortes ...

  10. Qualidade de goiabas ensacadas e manejadas com diferentes produtos fitossanitários, sob manejo orgânico

    OpenAIRE

    Pinheiro, Sarita Socorro Campos

    2006-01-01

    A cultura da goiabeira apresenta sérios problemas fitossanitários, geralmente controlados pelo uso intensivo de agrotóxicos, muitos dos quais não são registrados para este fim. O uso crescente e indiscriminado de agrotóxicos tem colocado em risco a saúde de consumidores e produtores rurais, além de provocar sérios problemas ambientais. Diante destas constatações, os consumidores têm optado por alimentos mais saudáveis, por exemplo, os alimentos orgânicos, produzidos sem a utilização de agrotó...

  11. Avaliação ecotoxicológica do fármaco Triclosan para invertebrados de água doce com ênfase em ensaios com sedimento marcado (\\"spiked sediment\\")

    OpenAIRE

    Fabio Hermes Pusceddu

    2010-01-01

    O aumento crescente da ocorrência de fármacos e produtos de cuidados pessoais (Pharmaceutical and Personal Care Products PPCPs) no ambiente aquático pode causar efeitos adversos à saúde humana e às comunidades aquáticas. O risco ambiental dos PPCPs, associado à possibilidade de efeitos sinérgicos entre estes compostos, assim como o aumento do uso de compostos orgânicos sintéticos, desencadearam grande preocupação com relação ao potencial tóxico à biota. O Triclosan (5-cloro-2-(2,4-diclorofen...

  12. Fusões e aquisições : influências da competição na avaliação da empresa alvo

    OpenAIRE

    Anselmo Filho, Fernando Antonio Fernandes

    2016-01-01

    Este trabalho analisou os fatores que importam na estimação do prêmio ofertado à empresa alvo. Ao mesmo tempo que analisou a competição no mercado corporativo, entendido como um fator exógeno à empresa alvo, avaliou condições internas à empresa alvo, como por exemplo seu endividamento, entendido como fator endógeno. A literatura sobre aquisição hostil tem substancialmente avançado, mas ainda existe interesse crescente em pesquisar o processo de aquisição hostil do lance inicial até o resultad...

  13. Padronização de sistemas de dupla amplificação para a detecção de DNA de Bartonella henselae em casos suspeitos de Bartonelose humana

    OpenAIRE

    Karina Hatamoto Kawasato

    2009-01-01

    Bartoneloses são infecções causadas por Bartonella spp e constituem zoonoses de importância crescente devido à gravidade da infecção em pacientes imunodeficientes. Existem muitas síndromes clínicas associadas às bartoneloses, desde quadros típicos de doença da arranhadura do gato até lesões cutâneas linfoproliferativas (angiomatose bacilar), ou granulomatosas em órgãos (peliose bacilar), passando por quadros neurológicos, oculares, endocardites e febre prolongada. O diagnóstico laboratorial d...

  14. Uma proposta de arquitetura de segurança para a detecção e reação a ameaças em redes SDN

    OpenAIRE

    Maxli Barroso Campos; Joberto Martins

    2017-01-01

    As Redes Definidas por Software (Software Defined Network – SDN) desacoplam o controle do encaminhamento de dados, oferecendo alta programabilidade e uma visão global da rede. A adoção dessa abordagem é crescente em redes empresariais, centros de dados e infraestruturas críticas como as redes elétricas inteligentes. No entanto, constitui-se um desafio não só prover segurança nessas redes de nova geração como também permitir que um ataque à rede seja suscetível a um procedimento de tratamento ...

  15. Entre o internacional e o local – impacto e efeitos de programas de educação em cooperação para o desenvolvimento. Um estudo de caso na Guiné-Bissau

    OpenAIRE

    Silva, Rui Manuel Ferreira da

    2017-01-01

    Tese de Doutoramento em Ciências da Educação (Especialidade em Desenvolvimento Curricular) Os sistemas educativos são um local instigante para explorar as questões inerentes à(s) globalização(ões) pelo seu papel na crescente importância dada à educação e à formação, e dentro destas à avaliação, essencialmente ao seu conceito fundador, o de medida. Neste âmbito, assistimos atualmente a uma global education policy, surgindo reformas viajantes que se instalam nos sistemas educativ...

  16. Plano estratégico “Empowering Lab ESEIG”

    OpenAIRE

    Fonseca, Jorge Nuno Aguiar Gomes da

    2016-01-01

    Os jovens ao longo do seu percurso escolar têm aspirações e expetativas elevadas quanto ao valor de empregabilidade dos diplomas a que tiveram acesso em todos os graus de ensino. Contudo, no recente contexto de crise económica, essas aspirações e expetativas socialmente nutridas pela escola e pela família têm sido em grande medida frustradas pelas crescentes dificuldades que os jovens portugueses de hoje têm vivido nos seus processos de inserção profissional. A nível individual, um jovem que ...

  17. Desenvolvimento de filmes biodegradaveis a partir de derivados do grão de quinoa (Chenopodium quinoia Willdenow) da variedade "Real"

    OpenAIRE

    Patricia Cecilia Araujo Farro

    2008-01-01

    Resumo: O grão de quinoa (Chenopodium quinoa, Willdenow) é um pseudocereal originário da América do Sul Andina, que tem gerado interesse industrial crescente e cultivo diversificado em diversos países de América do Norte e da Europa. Recentemente nos países da América Latina tem-se despertado um interesse comum na busca de tecnologias de desenvolvimento de biomateriais, como uma forma de diminuir a poluição gerada pelos resíduos sintéticos, utilizando os recursos naturais próprios da região. ...

  18. Opinião dos acadêmicos do curso de graduação em enfermagem em relação ao ensino básico

    Directory of Open Access Journals (Sweden)

    Iwa Keiko Aida Utyama

    1991-12-01

    Full Text Available Os autores, preocupados com a crescente diminuição de alunos matriculados no período regular na primeira disciplina do ciclo profissionalizante, propuseram-se a verificar as causas desta diminuição. Detectaram que esta diminuição deve-se em grande parte à reprovação. Ainda obtiveram as causas de reprovação atribuídas ao discente, ao docente, ao currículo e ao material bibliográfico.

  19. Estudo de impactos ambientais em solos: o caso da reciclagem de baterias automotivas usadas, tipo chumbo-ácido

    OpenAIRE

    Fernandes, Josely Dantas; Dantas, Edilma Rodrigues Bento; Barbosa, Juliana Nóbrega; Barbosa, Edimar Alves

    2011-01-01

    A ocorrência de solos contaminados com o elemento chumbo está se tornando cada vez mais comum. Ele é, essencialmente, um contaminante ambiental e suas concentrações no meio ambiente vem aumentando de acordo com a aplicação sempre crescente em diversos produtos industriais necessários à sociedade moderna. Hoje, usa-se o chumbo, por exemplo, na fabricação de canos, em revestimentos de cabos elétricos, de chapas para pias, cisternas e telhados e, principalmente, na indústria de baterias automoti...

  20. Environmental sustainability assessment of soybean and palm biodiesel systems : a life-cycle approach

    OpenAIRE

    Castanheira, Érica Geraldes

    2014-01-01

    Tese de doutoramento em Sistemas Sustentáveis de Energia apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra Em Portugal mais de 50% do biodiesel é produzido a partir de óleo de palma e soja importados. O crescimento mundial do consumo destes óleos vegetais para a produção de biocombustíveis, tem vindo a ser acompanhado por uma crescente preocupação relativa aos seus potenciais impactes ambientais, nomeadamente os impactes associados às práticas agrícolas e aos efei...

  1. Canine mammary tumours: new insights into prognosis and molecular classification

    OpenAIRE

    Quaresma, Adelina Maria Gaspar Gama

    2008-01-01

    Tese de Doutoramento em Ciências Veterinárias Na espécie canina, os tumores mamários espontâneos representam a segunda neoplasia mais comum, sendo apenas ultrapassados pelos tumores de pele. Considerando os indivíduos do sexo feminino, os tumores de mama constituem a neoplasia espontânea mais frequente, representando os tumores malignos cerca de 50% dos casos observados. Estes factos suscitam um interesse crescente na pesquisa de factores de prognóstico credíveis na área dos tumores mamári...

  2. Processos preliminares da infecção viral: estudo estereoquímico da proteína E do Dengue

    OpenAIRE

    Ricardo Oliveira dos Santos Soares

    2013-01-01

    A Infecção pelo dengue afeta todas as regiões tropicais e subtropicais do globo, registra aproximadamente 390 milhões de casos por ano, e se destaca como um problema emergente de proporções crescentes, especialmente no Brasil, que atualmente responde por 60% dos casos no continente americano. Assim, ações para criar, adaptar e atender as condições para promover avanços na compreensão do processo de infecção pelo vírus em nível molecular pode ser de grande valor, tanto para enfrentar os desafi...

  3. Desenvolvimento de um chocolate meio amargo com maior percentual de proteína

    OpenAIRE

    Andrea Bordin Schumacher

    2008-01-01

    O chocolate tem apresentado crescente consumo, boa digestibilidade devido a sua composição e tem sido amplamente estudado por suas propriedades antioxidantes. Por outro lado, este alimento possui altos percentuais de carboidratos e gordura e baixo conteúdo de proteínas. Neste contexto, foram desenvolvidas formulações de chocolate meio amargo com objetivo de aumentar o valor protéico deste produto. Para isto foi utilizado o pseudocereal quinoa (Chenopodium quinoa Wild) como adição ao chocolate...

  4. Secagem de tomate (Lycopersicon esculentum Mill) para conserva : estudo de parametros com base na qualidade final

    OpenAIRE

    Gisele Anne Camargo

    2000-01-01

    Resumo: o tomate seco tem apresentado crescente aplicação na culinária brasileira, principalmente, como ingrediente de massas, pizzas e também no consumo imediato. Com a finalidade de estudar a influência de parâmetros de secagem sobre a eficiência do processo e sobre a qualidade do produto final, foi desenvolvida uma pesquisa utilizando tomates de duas variedades: uma variedade industrial (Rio Grande) e outra de tomate de mesa (Debora Plus). Cada uma das variedades foi analisada quanto ao co...

  5. The tax behavior of taxpayers: literature review

    OpenAIRE

    Cruz, Sérgio; Pinto, Catarina; Abrunheiro, Lígia

    2014-01-01

    O desenvolvimento das sociedades, a crescente educação e consciencialização dos indivíduos acerca dos impostos e medidas fiscais, conduziu a alterações no comportamento dos contribuintes no que diz respeito à perceção e cumprimento fiscal. Recolhendo e sintetizando a literatura existente, efetuámos uma revisão de literatura de forma a perceber quais as variáveis que influenciam os comportamentos dos contribuintes no que respeita ao seu (in)cumprimento e de que forma se manifestam na socied...

  6. A ATIVIDADE DO TRABALHO COMO MEIO PARA MANUTENÇÃO DA SAÚDE DOCENTE: UMA PERSPECTIVA ERGOLÓGICA. WORK ACTIVITY AS A WAY OF MAINTAINING TEACHER’S HEALTH: AN ERGOLOGIC PERSPECTIVE

    OpenAIRE

    Vieira Júnior, Paulo Roberto; Santos, Eloisa Helena

    2011-01-01

    Este artigo é produto de dissertação de mestrado, construída a partir de uma abordagem qualitativa e exploratória que analisou estratégias para manutenção da saúde pela atividade docente. Para tal realizou entrevistas semiestruturadas com seis professores do Ensino Fundamental de duas escolas da região metropolitana de Belo Horizonte - MG que desde a posse no cargo de professor não se afastaram de suas atividades por motivos de doença. As crescentes estatísticas de desordem física e emocional...

  7. Desenvolvimento de uma abordagem computacional para a descoberta de compostos-líderes para fármacos anticancerígenos

    OpenAIRE

    Cruz, Sara Miguel Dinis Mamede da

    2016-01-01

    Atualmente o cancro é uma das principais causas de morte, causando uma crescente demanda para a descoberta de fármacos para o seu tratamento. O objetivo desta dissertação foi a construção de modelos computacionais para auxiliar a descoberta de novos compostos líder anticancerígenos contra o cancro do cólon. Foram realizados dois diferentes estudos da Relação Quantitativa Estrutura Atividade (QSAR), o primeiro intitulado Modelo A, que utilizou conjuntos de descritores estruturais e fingerpr...

  8. Intussusception in adults: US and CT findings

    International Nuclear Information System (INIS)

    Wolff, Laura; Azulay, Guillermo; Pfister, Martin; Florenzano, Nestor V.; Vega, Alejandro de la; Serini, Veronica

    2002-01-01

    Ileocolic invagination is the penetration of an ileum segment into the right colon. Four cases of ileocolic intussisception are described by US and CT with its surgical pathologic confirmation. Three different patterns are described by CT which reflect its severity and duration. These are: target, in layers and kidney form. Ultrasound signs are: 'pseudo kidney', 'target' and 'donut crescent' being the latter the only distinctive sign. Flow suggests that the intussusception could be reductable. The presence of fluid in peritoneal cavity could mean ischemia and irreductibility. (author)

  9. Misturas de um solo laterítico com cimento e bentonita para uso em cortinas verticais Mixtures of a lateritic soil with cement and bentonite for slurry wall purposes

    OpenAIRE

    Priscila Batista; Adilson do Lago Leite

    2010-01-01

    É crescente mundo afora o uso de cortinas verticais para contenção da contaminação em água subterrânea. Os solos lateríticos, pela sua ampla distribuição no Brasil, possuem grande potencial de aplicação nessas obras. Entretanto algumas questões ainda carecem de maior investigação, como a interação e compatibilidade desses solos com a bentonita e o cimento, principais aditivos usados para melhorar as propriedades das cortinas. O presente artigo avalia propriedades de um solo laterítico e suas ...

  10. Complementary parameters of requirements to fixing identity and quality of bakery products

    OpenAIRE

    Esteller, Mauricio Sergio; Lannes, Suzana Caetano da Silva

    2005-01-01

    É crescente o número de marcas e produtos panificados oferecidos ao mercado. Técnicas e aparelhagens recentes permitem uma melhor caracterização de produtos derivados do trigo. este trabalho propõe a reavaliação da legislação brasileira para esta categoria de alimento. Foram analisadas diferentes marcas de pães e torradas nos parâmetros de porosidade da massa, textura, cor, volume específico, densidade e umidade. Foram obtidos valores característicos para cada grupo de produtos, mostrando que...

  11. FATORES DETERMINANTES DA TOMADA DE DECISÃO PARA O CONSUMO DE PRODUTOS ORGÂNICOS EM UMA FEIRA LIVRE

    OpenAIRE

    Ilton Belchior Cruvinel; Daneil Staciarini Corrêa; Nelson Jorge da Silva Junior; Joelmir Feliciano; Rogério José de Almeida

    2017-01-01

    Cada vez mais se desenvolve a consciência da importância do consumo de produtos orgânicos. Tal falta pode ser observado na crescente abertura de feiras livras especializadas nesse tipo de produto. O presente artigo objetivou analisar os fatores associados ao processo de tomada de decisão de compra de produtos orgânicos por consumidores de uma feira livre na cidade de Goiânia-GO. Realizou-se de um estudo transversal analítico com abordagem quantitativa. Foram entrevistadas 84 pessoas. Ut...

  12. Contribuições do design estratégico para o desenvolvimento de novos modelos de negócios no contexto de empresas startups

    OpenAIRE

    Almada, Viviane da Silva

    2015-01-01

    As organizações, especialmente as empresas startups, estão inseridas em mercados onde a necessidade de um olhar direcionado para a resolução de problemas complexos e a busca de inovação é cada vez mais crescente. Neste contexto destaca-se o design estratégico, uma abordagem que permite a expansão do espaço do problema a ser resolvido, do mesmo modo que aumenta as possibilidades de inovação e traz uma dimensão projetual de constante experimentação. Esta pesquisa tem como objetivo fornece...

  13. Calendars and years astronomy and time in the ancient near east

    CERN Document Server

    Steele, John M

    2007-01-01

    Dates form the backbone of written history. But where do these dates come from? Many different calendars were used in the ancient world. Some of these calendars were based upon observations or calculations of regular astronomical phenomena, such as the first sighting of the new moon crescent that defined the beginning of the month in many calendars, while others incorporated schematic simplifications of these phenomena, such as the 360-day year used in early Mesopotamian administrative practices in order to simplify accounting procedures. Historians frequently use handbooks and tables for conv

  14. Modelação do aquecimento de células por radiação laser: aplicação a sistemas de libertação prolongada de medicamentos

    OpenAIRE

    Vilhena, Henrique Faria Blanc de

    2011-01-01

    Tese de mestrado em Engenharia Física, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2011 Tem surgido, nos últimos anos, um crescente interesse na utilização de partículas de dimensões microscópicas e nanoscópicas como sistemas de libertação de medicamentos. As vantagens decorrentes destes sistemas têm a ver, principalmente, com a possibilidade de tratamentos terapêuticos de doenças como o cancro com uma maior eficiência e um número reduzido de efeitos secundários...

  15. Mídias sociais

    OpenAIRE

    Cruz, Fernando Silvério

    2017-01-01

    Pautando-se na importância da revolução tecnológica e no crescente uso das mídias sociais como ferramenta de marketing digital, este estudo tem como objetivo investigar, na perspectiva do marketing digital, se os jovens consumidores nativos digitais, estudantes de um Instituto Federal, são influenciados pelas mídias sociais e, em caso, afirmativo, como se dá essa influência. O estudo também objetiva a) mapear o perfil desses jovens nativos digitais como consumidores usuários de mídias sociais...

  16. Cidades Inteligentes

    OpenAIRE

    Gouveia, Luís Borges

    2015-01-01

    Apresentação realizada na Universidade Lusófona, Porto, 14 de abril 2015 Cidades Inteligentes: a exploração do digital - A importância das cidades é crescente. - É nestes espaços que conflui muita da atividade humana e se joga a qualidade de vida dos territórios que estas representam e lideram, quer do ponto de vista económico, quer cultural e naturalmente político. - Os desafios e as oportunidades proporcionadas pelo digital exigem uma abordagem estruturada que as potencie as cid...

  17. Cogumelos comestíveis: uso, conservação, características nutricionais e farmacológicas

    OpenAIRE

    Joice Vinhal Costa Orsine; Luíssa Marques Brito; Maria Rita Carvalho Garbi Novaes

    2013-01-01

    É crescente o interesse na produção e consumo de cogumelos devido às suas qualidades nutricionais e terapêuticas, o que tem estimulado sua utilização como alimento funcional e como coadjuvante no tratamento de enfermidades como o câncer. O presente trabalho tem por objetivo discutir o uso de cogumelos como alimento e com fins medicinais pela população através da apresentação de trabalhos publicados, considerando a composição química e nutricional, aspectos farmacológicos e tóxicos para o uso ...

  18. Elaboração de um plano de marketing cultural para o Museu de Marinha

    OpenAIRE

    Nunes, Patrícia Lavrador Teixeira

    2010-01-01

    Dissertação apresentada à Escola Superior de Comunicação Social para obtenção de grau de mestre em Publicidade e Marketing. A pertinência do marketing nas instituições museológicas é, hoje em dia, um facto incontornável. É necessário oferecer novos produtos e serviços a um novo tipo de consumidor, mais informado e exigente, e para tal, é imprescindível conhecê-lo. Apesar de, actualmente, se registar um interesse crescente no marketing cultural, subsistem ainda algumas resistênc...

  19. Blogues de moda: a influência dos blogues no consumo de moda

    OpenAIRE

    Santos, Vânia Raquel Teixeira

    2014-01-01

    Dissertação apresentada à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Publicidade e Marketing. A evolução das comunidades online e das redes sociais tem vindo a conferir cada vez mais poder ao consumidor. Os blogues têm vindo a assumir um protagonismo crescente no consumo. Este trabalho aborda o consumo de moda em blogues de moda, ou seja, o estudo dos blogues de moda como influenciadores do processo de consumo de moda. A propagação da...

  20. Estudo da interação entre borrachas comerciais e misturas de biodiesel/diesel por espectroscopia de ressonância magnética nuclear

    OpenAIRE

    Lorena Mara Alexandre e Silva

    2014-01-01

    Hoje em dia o biodiesel tem se consolidado como uma matriz energética importante em muitos países. Os elastômeros integram uma classe importante de materiais, com aplicação em diversas áreas e principalmente, são vastamente utilizados em motores automobilísticos. Assim, a compatibilidade dos elastômeros com biodiesel é uma preocupação crescente. Para obter e correlacionar informações importantes das fases compartimentadas no sistema borracha/combustível, foram empregados a RMN em baixo, alto ...

  1. Ambienti narrativi per l'apprendimento

    Directory of Open Access Journals (Sweden)

    Giuliana Dettori

    2006-01-01

    Full Text Available Analisi degli ambienti di apprendimento narrativi e la loro potenzialità per l’apprendimento. Le storie possono essere uno strumento a sostegno dell’apprendimento che risulta naturale per tutti, e specialmente per bambini e ragazzi. Lo sviluppo delle TIC (Tecnologie dell’Informazione e della Comunicazione ed il loro crescente utilizzo in ambito didattico hanno fornito un’ampia gamma di strumenti per potenziare l’utilizzo educativo della narrativa, dando origine ad una consistente varieta’ di ambienti di apprendimento narrativi con obiettivi formativi differenti ed applicabili a diversi ambiti di studio.

  2. The place of the unicorn in today’s marketplace : a new reality for start-ups

    OpenAIRE

    Costa, João Pedro Santos

    2017-01-01

    Criar empresas de valorizações exponenciais é um objetivo comum entre empreendedores e investidores, mas subsiste a dúvida sobre como fazê-lo. Este estudo pretende contribuir para colmatar esta lacuna na literatura atual – sobre como criar os chamados unicórnios. Devido ao aparecimento crescente de empresas valorizadas em biliões de dólares nos últimos anos, a sua compreensão, assim como a sua posição no mercado atual, e as ameaças, oportunidades e vantagens competitivas das mesmas, tornou-se...

  3. Consumo de Café e o Risco de Desenvolver Diabetes Mellitus tipo 2

    OpenAIRE

    Ferreira, Diana Isabel Gomes

    2015-01-01

    A diabetes mellitus tipo 2 é uma doença crónica, que está associada a altas taxas de morbidade e mortalidade prematura. O aumento da indicência desta patologia, muito em parte pelos actuais estilos de vida adoptados, tem levado ao interesse do estudo da DM2. O consumo regular de café tem vindo a ser associado de forma positiva com a DM2 e por ser umas das bebidas mais consumidas na actualidade, leva a uma crescente preocupação em conhecer os seus benefícios e malefícios, desencadeando o in...

  4. Kikuchi's lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features.

    Science.gov (United States)

    Tsang, W Y; Chan, J K; Ng, C S

    1994-03-01

    Seventy-five cases of Kikuchi's lymphadenitis, a self-limiting pseudomalignant condition, were reviewed to determine the spectrum of histologic findings. There were 55 females and 20 males; ages ranged from 9 to 57 years (mean, 25.5). Most patients presented with cervical lymphadenopathy (68 cases). Associated clinical findings were fever (20/52) and leukopenia (15/33). Serum antinuclear antibodies were negative in 15 patients among 16 tested. Among 32 patients with follow-up information, 31 remained well, including one who developed recurrence after 2 years. One patient died of fatal myocardial disease during the active disease. Histologically, the lymph nodes showed paracortical hyperplasia, often associated with a starry-sky appearance resulting from interspersed histiocytes and immunoblasts. The consistent finding was the presence of variable-sized discrete or confluent nodules in the paracortex composed of the following: (a) karyorrhectic and eosinophilic granular debris; (b) histiocytes, many of which were phagocytic and possessed distinctive peripherally placed crescentic nuclei and voluminous cytoplasm containing eosinophilic or karyorrhectic debris (for which we propose the designation crescentic histiocytes), mixed with nonphagocytic histiocytes having twisted or reniform nuclei which were often centrally placed; (c) plasmacytoid monocytes, which were medium-sized cells with eccentrically placed round nuclei and amphophilic cytoplasm; and (d) variable numbers of immunoblasts, which sometimes showed atypia such as irregular nuclear foldings and coarse chromatin. Neutrophils were absent or very sparse. In some nodules, coagulative necrosis was present in the center (45 cases). Foamy histiocytes were found in 23 cases, and they predominated in 11. Small clusters of plasmacytoid monocytes were noted in the paracortex in 40 cases. Perinodal inflammation was a common finding, and perinodal involvement by the karyorrhectic process occurred in 15 cases. In

  5. Análise dos impactos socioeconômicos da expansão do setor sucroenergético

    OpenAIRE

    Leandro Gilio

    2015-01-01

    O setor sucroenergético tem grande representatividade histórica no agronegócio brasileiro e vem ganhando notoriedade no atual contexto da emergência da economia de baixo carbono e da crescente demanda mundial por fontes alternativas e renováveis de energia. Como consequência do crescimento da produção e consumo de etanol e açúcar, intensificado na última década, o avanço da cultura canavieira sobre novas áreas suscita uma série de questões de cunho ambiental, econômico e social acerca dos pos...

  6. Efeito da erva-mate (Ilex paraguariensis) sobre o metabolismo de ratos tratados com dieta hiperlipídica

    OpenAIRE

    Luana Ferreira Gomes

    2012-01-01

    A obesidade é definida por um acúmulo excessivo de gordura na forma de tecido adiposo. É um problema crescente, resultando em significativa morbidade e mortalidade por doenças relacionadas, bem como uma redução da qualidade de vida. O acúmulo excessivo de tecido adiposo que caracteriza a obesidade está diretamente relacionado ao desenvolvimento patologias que, coletivamente, compõem a chamada síndrome metabólica. O tecido adiposo é o principal reservatório energético do organismo, mas também ...

  7. O papel do fornecedor de TI na transformação dos processos de negócio da pequena e média empresa : um estudo de caso

    OpenAIRE

    Alexandre Eduardo Pinto de Almeida Gabriel

    2007-01-01

    Nos últimos anos, a adoção de TI nas empresas tem se caracterizado pelo crescente uso dos sistemas integrados de gestão, particularmente dos sistemas ERP (Enterprise Resource Planning). Devido à sua natureza integrada e abrangente, esta ferramenta traz grande potencial de crescimento às empresas que o utilizam, através da melhoria de seus processos de negócio. As pequenas e médias empresas formam um mercado atrativo para os fornecedores de tais sistemas, dado que a oferta de ERP para empresas...

  8. MMS Encounters with Reconnection Diffusion Regions in the Earth's Magnetotail

    Science.gov (United States)

    Torbert, R. B.; Burch, J. L.; Argall, M. R.; Farrugia, C. J.; Alm, L.; Dors, I.; Payne, D.; Rogers, A. J.; Strangeway, R. J.; Phan, T.; Ergun, R.; Goodrich, K.; Lindqvist, P. A.; Khotyaintsev, Y. V.; Giles, B. L.; Rager, A. C.; Gershman, D. J.; Kletzing, C.

    2017-12-01

    The Magnetospheric Multiscale (MMS) fleet of four spacecraft traversed the Earth's magnetotail in May through August of 2017 with an apogee of 25 Re, and encountered diffusion regions characteristic of symmetric reconnection. This presentation will describe in-situ measurements of large electric fields, strong electron cross-tail and Hall currents, and electron velocity distributions (frequently crescent-shaped) that are commonly observed in these regions. Positive electromagnetic energy conversion is also typical. The characteristics of symmetric reconnection observations will be contrasted with those of asymmetric reconnection that MMS observed previously at the dayside magnetopause.

  9. Da “política de solos” a uma política de protecção do solo.

    OpenAIRE

    Alexandre, Carlos

    2005-01-01

    O solo é um recurso vital para o meio ambiente e para as sociedades humanas A urbanização crescente e a evolução tecnológica das sociedades desenvolvidas tendem a induzir no cidadão comum um certo alheamento acerca da nossa dependência do solo. No entanto, 99% da biomassa para alimentação e para outros fins básicos provém do solo (estatísticas da FAO, 2004) o que mostra como este é um recurso vital para a humanidade, praticamente tanto como o ar e a água. Nes...

  10. Polarization of microglia and its role in bacterial sepsis.

    Science.gov (United States)

    Michels, Monique; Sonai, Beatriz; Dal-Pizzol, Felipe

    2017-02-15

    Microglial polarization in response to brain inflammatory conditions is a crescent field in neuroscience. However, the effect of systemic inflammation, and specifically sepsis, is a relatively unexplored field that has great interest and relevance. Sepsis has been associated with both early and late harmful events of the central nervous system, suggesting that there is a close link between sepsis and neuroinflammation. During sepsis evolution it is supposed that microglial could exert both neurotoxic and repairing effects depending on the specific microglial phenotype assumed. In this context, here it was reviewed the role of microglial polarization during sepsis-associated brain dysfunction. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Descoloração de efluentes têxteis sintéticos por catálise enzimática

    OpenAIRE

    Silva, Maria Cristina; Corrêa, Angelita D.; Amorim, M. T. Pessoa de; Oliveira, Sara L. C.; Duarte, António A. L. Sampaio; Torres, Juliana A.

    2010-01-01

    Peroxidases podem ser utilizadas em processos de descoloração no tratamento de efluentes têxteis. Há um interesse crescente por novas fontes desta enzima, e por processos de obtenção viáveis economicamente.1Neste trabalho o potencial de descoloração de efluentes têxteis sintéticos por peroxidase extraída de nabo (Brassica campestre ssp. rapifera) é avaliado. Para a obtenção da enzima de baixa pureza utiliza-se um processo de baixo custo, Os efluentes utilizados nos ensaios são efluentes sinté...

  12. Relação entre as disfunções temporomandibulares e a postura cervical

    OpenAIRE

    Elias, Millie Bouskela

    2017-01-01

    As disfunções temporomandibulares (DTMs) afetam os músculos da mastigação e/ou a articulação temporomandibular, bem com, estruturas associadas podendo levar ao aparecimento de uma série de sinais e sintomas muito diversos. Devido à íntima relação existente entre os músculos da cabeça e região cervical com o sistema estomatognático, e sendo crescente o número de pacientes com DTMs e concomitantemente com alterações posturais, alguns autores, sugerem a participação da postura cor...

  13. Radiological characteristics of pulmonary hydatid disease in children Less common radiological appearances

    Energy Technology Data Exchange (ETDEWEB)

    Erdem, C. Zuhal E-mail: sunarerdem@yahoo.com; Erdem, L. Oktay

    2003-02-01

    Objective: To evaluate the chest roentgenogram and CT characteristics of pulmonary hydatid disease (PHD). Material and methods: Forty-seven (27 male and 20 female, aged between 3 and 11 years) consecutive pediatric patients with surgically proven pulmonary hydatid cysts were enrolled for the study. Posteroanterior and lateral chest roentgenograms, CT of the chest, and laboratory findings (latex agglutination, Casoni skin test, and eosinophil count) were obtained from all of the patients. The radiological features (localization, internal architecture, number, diameter) were determined. Results: On CT examination, a total of 79 cysts were determined. On chest roentgenogram, 57 of 79 cysts were detected in all patients. Single cysts were seen in 33 patients, while multiple cysts were seen in 14. Median CT density of the cysts was 21 Hounsfield units (HU) (0-80). There were six giant cysts (>10 cm of cyst diameter). The crescent sign, water lily sign, and air-fluid level were seen in two, five and eight of the cysts, respectively. Apart from the classically described features of pulmonary hydatid cysts of the lung, a crescent-shaped rim of air at the lower end of the cyst (inverse crescent sign) was detected in three cysts. All of the liquid content of the cyst was expelled to the bronchial system (dry cyst sign) was observed in seven cysts. There were two infected cysts. Heavily calcified curvilinear cyst wall was present in one cyst. Pericystic reaction in the lung tissue was observed in five patients. Other features included pleural effusion (n=2), mediastinal shift (n=6) and atelectasis (n=7). Conclusions: Chest roentgenogram is helpful for diagnosis of intact cysts but, it is impossible to define entire morphology of the complicated cysts. CT imaging recognize certain details of the lesions and discover others that are not visible by conventional radiography. In conclusion, CT examination should be done to elucidate cystic nature of the lung mass and for accurate

  14. Formation of substrate-based gold nanocage chains through dealloying with nitric acid

    Directory of Open Access Journals (Sweden)

    Ziren Yan

    2015-06-01

    Full Text Available Metal nanocages have raised great interest because of their new properties and wide applications. Here, we report on the use of galvanic replacement reactions to synthesize substrate-supported Ag–Au nanocages from silver templates electrodeposited on transparent indium tin oxide (ITO film coated glass. The residual Ag in the composition was dealloyed with 10% nitric acid. It was found that chains of Au nanocages were formed on the substrate surface during dealloying. When the concentration of HNO3 increased to 20%, the structures of nanocages were damaged and formed crescent or semi-circular shapes. The transfer process on the substrate surface was discussed.

  15. Desenvolvimento de nÃctares mistos à base de caju (Anacardium occidentale L) e aÃaà (Euterpe oleracea Mart.)

    OpenAIRE

    Analia Maria Pinheiro

    2008-01-01

    O setor que vem crescendo nos Ãltimos anos à o de bebidas. Em todos os paÃses os levantamentos estatÃsticos revelam nÃmeros crescentes de consumo, tanto per capita quanto global. Esses valores sÃo mais expressivos quando se refere a bebidas obtidas de frutas, pelo fato das mesmas se constituÃrem fontes importantes de vitaminas e minerais para a dieta humana, alÃm de seus atrativos sabores. O Norte e Nordeste do Brasil, por exemplo, sÃo regiÃes privilegiadas neste particular. Portanto, pode-se...

  16. O uso da eletroglotografia, eletromiografia, espectografia e ultrassom nos estudos de fala - revisão teórica

    Directory of Open Access Journals (Sweden)

    Fernanda Wiethan

    2015-03-01

    Full Text Available O emprego de novas tecnologias na avaliação e terapia de fala a partir de uma revisão de artigos publicados nos últimos 5 anos é o tema deste estudo, que tem por objetivo realizar uma revisão bibliográfica dos estudos nacionais e internacionais que utilizaram os recursos: eletroglotografia, espectrografia, ultrassonografia e eletromiografia na avaliação e terapia das alterações de fala. Existe um crescente interesse da inserção desses recursos nos estudos de fala, contudo, os trabalhos existentes que os correlacionam ainda são escassos.

  17. International Semiconductor Laser Conference. Held in Boston, Massachusetts on August 29 - September 1, 1988

    Science.gov (United States)

    1988-11-01

    gastronomically rewarding. Excellent restaurants serving seafood, "natural-foods’, and European and Asian dishes are everywhere. A baseball game at nearby...Laboratories, Holmdel, NJ, USA .......... 6-7 A:4 9:00 am DFB Lasers with a Crescent-Shaped Active Layer on a Corrugated p-type Substrate Y Ogawa, H. Horikawa...Berkeley, CA, USA ; W.M. Clark Jr., E.H. Stevens and MW Utlaut, Hughes Research Laboratories, Malibu, CA, USA .. 12-13 A:7 9:45 am Nanosecond Wavelength

  18. Indicações e complicações dos bifosfonatos em ortopedia

    OpenAIRE

    Marques, Manuel de Almeida

    2014-01-01

    Trabalho final de mestrado integrado em Medicina (Ortopedia), apresentado á Faculdade de Medicina da Universidade de Coimbra Contexto: Ao longo dos últimos anos, a osteoporose tem vindo a revelar-se um problema de saúde pública de crescente importância, contribuindo para o aumento da prevalência de fraturas na população idosa. O objectivo deste trabalho foi proceder a uma revisão dos estudos publicados sobre a eficácia dos bifosfonatos na redução do risco de fratura osteoporótica, o seu...

  19. Estudo numérico-analítico de modelos reológicos unidimensionais viscoelásticos, elastoplásticos e viscoplásticos

    OpenAIRE

    Carvalho, Marcos Andrade de

    2014-01-01

    Os materiais com comportamento viscoelástico e viscoplástico vêm gradativamenteatraindo interesse industrial e adquirindo maior espaço entre aplicações práticas taiscomo o uso de dissipadores de energia sísmica. Esse crescente interesse tem estimuladoo desenvolvimento de modelos e estratégias de modelagem computacional nesse tipo dematerial. Estes materiais se comportam de modos muito complexos, por isso éimportante fazer um estudo para tentar simular o seu comportamento o mais próximopossíve...

  20. As mensagens estratégicas das "melhores e maiores" : a retórica das organizações na WEB

    OpenAIRE

    Borges, Jacquelaine Florindo

    2005-01-01

    O uso da Internet é crescente, desde os anos 90, como meio pelo qual empresas, governos e instituições diversas vêm se comunicando. A comunicação, também, tornou-se elemento estratégico para as organizações que, num contexto globalizado e interconectado, têm mais visibilidade perante diferentes públicos e sua legitimidade passa a ser avaliada pela capacidade de responder às necessidades, interesses, valores, desejos e sonhos desses públicos. As mudanças no contexto dos negócios decorrentes...

  1. Ecologia Comportamental dos cães domésticos em áreas rurais e urbanas do município de Viçosa, MG

    OpenAIRE

    Martinez, Edilberto Nobrega

    2012-01-01

    Após a revolução industrial principalmente a partir do século XX, auge do êxodo rural, houve um incremento do processo de urbanização no Brasil. Nos dias atuais o progresso de atividades econômicas tem contribuído para a crescente aquisição de animais de estimação nos lares brasileiros, principalmente cães (Canis lupus familiaris). Para contemplar essa demanda, milhares de novos indivíduos nascem todos os anos sem um controle adequado. Este processo corrobora com o aumento de cães abandonados...

  2. Impact of the anthelminthic treatment of dogs in environmental contamination of sidewalks by Larva Migrans agents

    OpenAIRE

    Ramires, Lívia Magosso

    2014-01-01

    As geohelmintoses são importantes doenças que acometem seres humanos. Além de serem ocasionadas por parasitos que têm o homem como hospedeiro definitivo, cães e gatos podem ser responsáveis pela contaminação ambiental por agentes com potencial zoonótico. Entres esses agentes, destacam-se Toxocara spp. e Ancylostoma spp., que podem ocasionar as síndromes de Larva migrans visceral/ocular e cutânea, respectivamente. O número crescente de pessoas que criam cães e gatos sem controle parasitário e ...

  3. CONSUMO COLABORATIVO: TENDÊNCIA DE CONSTRUÇÃO DE CONHECIMENTO E NEGÓCIOS NO MERCADO DIGITAL DE PRODUTOS USADOS

    OpenAIRE

    Cláudia Resem Paixão; Richard Perassi Luiz de Souza

    2015-01-01

    No contexto da economia criativa, o Consumo Colaborativo é crescente e impulsionado pela interação coletiva, especialmente, no ambiente virtual do mercado contemporâneo. Neste estudo, um website brasileiro de compra e venda de produtos usados ou de “segunda mão” https://www.enjoei.com.br é indicado como exemplo de ambiente colaborativo e promotor de conhecimento, comunicação e negócios de e-commerce. O problema de pesquisa decorreu da necessidade de identificação de tendências decorrentes das...

  4. Fobia social na adolescência : o impacto e prevalência de uma perturbação silenciosa

    OpenAIRE

    Carvalho, Ana Raquel da Cruz

    2012-01-01

    Dissertação de mestrado em Psicologia (Intervenções Cognitivo-Comportamentais nas Perturbações Psicológicas da Saúde) apresentada à Faculdade de Psicologia e Ciências da Educação da Universidade de Coimbra. Não obstante a crescente investigação sobre os aspetos epidemiológicos e clínicos da fobia social, existe ainda uma escassez de informação sobre esta perturbação na adolescência. A presente investigação teve como objetivo principal estudar o impacto da fobia social generalizada...

  5. Análise de controladores eletrônicos em sistemas de distribuição de energia

    OpenAIRE

    Alampi Filho, Sergio [UNESP

    2005-01-01

    O número crescente de cargas não-lineares, bem como altas taxas de energia pagas pelos consumidores, com tributações adicionais, tais como multas por baixo ou alto fator de potência, tarifas elevadas em horários de ponta e necessidade de elevados contratos de demanda, para suprir possíveis ultrapassagens de contrato, estão entre as principais motivações técnicas para a realização desta pesquisa. Sob esta perspectiva, os principais controladores FACTS são apresentados, com enfoque principal no...

  6. Fundamentos sobre energia das ondas (e sistemas fotovoltaicos para bombagem de água)

    OpenAIRE

    Carneiro, Joaquim A. O.

    2017-01-01

    Texto de apoio às aulas da UC "Energias Renováveis II" do Mestrado em Ciências e Tecnologias do Ambiente Devido ao crescente aumento do consumo energético, os últimos anos têm sido caracterizados por uma aposta estratégica na procura de fontes de energia alternativas aos combustíveis fósseis tradicionais. Este documento aborda os principais fundamentos adstritos a dois diferentes tipos de fontes alternativas de energia, nomeadamente a energia das ondas do oceano e a energia solar fotovolta...

  7. Avaliação da conversão da energia fotovoltaica em sistemas isolados

    OpenAIRE

    Carneiro de Oliveira, Kleber

    2007-01-01

    Esta dissertação apresenta a importância do uso da energia solar fotovoltaica em relação ao impacto ambiental causado pelas fontes de energia convencionais. O fato da energia solar fotovoltaica ser uma energia livre de poluentes e crescente devido à diminuição dos preços dos painéis fotovoltaicos a deixa em condições de competir com as outras fontes de energia. São apresentados aspectos gerais sobre geração fotovoltaica e são discutidos o princípio de funcionamento, o processo ...

  8. Simulação de uma planta piloto de Biodisel com estudo da viabilidade econômica preliminar usando o ASPEN/HYSYS

    OpenAIRE

    Pinho Costa Souza, Thibério

    2011-01-01

    Nos últimos anos o biodiesel se tornou uma alternativa para a demanda crescente de combustível. O próximo passo é conseguir produzir um biodiesel economicamente competitivo com o diesel fóssil em um processo em nível industrial. Este trabalho visa estudar do ponto de vista computacional, uma planta piloto de biodiesel, simulando o processo desde a reação de transesterificação de óleos vegetais, chegando até a purificação do biodiesel, utilizando o APEN/HYSYS. Além disso, foi feito o estudo da...

  9. SYMANTEC : reorganização do canal de vendas indirecto

    OpenAIRE

    Lourenço, Rita Isabel Clemente

    2013-01-01

    Projecto Empresa Mestrado em Marketing / Classificação JEL: M31 (Marketing), L11 (Production, Pricing and market structure, size distribution of firms), O24 (Trade Policy) As empresas de sucesso no mercado de tecnologias, muitas vezes têm a sua estratégia assente em canais de venda indirectos. A utilização de um canal externo é uma situação muito comum neste tipo de mercado e é uma tendência crescente em termos de importância. Assim, as questões relacionadas com os canais de vendas afectam...

  10. Gestão da cadeia de suprimentos e a segurança do alimento : uma pesquisa exploratória na cadeia exportadora de carne suína

    OpenAIRE

    Talamini, Edson; Pedrozo, Eugenio Avila; Silva, Andrea Lago da

    2005-01-01

    A crescente preocupação com a segurança dos alimentos propõe que as cadeias produtivas tenham maior domínio sobre o processo produtivo. A Gestão da Cadeia de Suprimentos, aqui genericamente tratada de SCM (Supply Chain Management), pode apresentar importante contribuição na obtenção de um processo mais uniforme ao longo da cadeia, facilitando o compartilhamento de informações e práticas produtivas. Este artigo tem como objetivo principal identificar a estrutura, as ligações e o nível de integ...

  11. Avaliação de desempenho de cadeias de suprimento: um estudo exploratório em uma cadeia de carne de frango no Brasil

    OpenAIRE

    Csillag, João Mário; Pereira, Susana Carla Farias

    2004-01-01

    Dentro dos diversos setores e atividades econômicas, o agribusiness vem se desenvolvendo com grande força no mundo, impulsionado, sobretudo, pelo aumento da população e a crescente demanda por alimentos. A idéia e o estudo de cadeias já é há algum tempo difundido na literatura sobre Agribusiness, mas com origens, conotações, referenciais teóricos e metodologias específicas ao setor e diferentes das que vem marcando e definindo as pesquisas sobre Supply Chain Management (SCM). Enquanto os estu...

  12. Supply chain management and food safety: exploratory research into Brazil's pork export supply chain

    OpenAIRE

    Talamini, Edson; Pedrozo, Eugenio Avila; Silva, Andrea Lago da

    2005-01-01

    A crescente preocupação com a segurança dos alimentos propõe que as cadeias produtivas tenham maior domínio sobre o processo produtivo. A Gestão da Cadeia de Suprimentos, aqui genericamente tratada de SCM (Supply Chain Management), pode apresentar importante contribuição na obtenção de um processo mais uniforme ao longo da cadeia, facilitando o compartilhamento de informações e práticas produtivas. Este artigo tem como objetivo principal identificar a estrutura, as ligações e o nível de integ...

  13. Centenários: que redes sociais?

    OpenAIRE

    Araújo, Lia; Oscar, Ribeiro

    2012-01-01

    As relações sociais têm sido apontadas como um inigualável recurso de adaptação, principalmente na fase mais avançada da vida, em que os constrangimentos e perdas são crescentes. A revisão dos principais estudos que focam a dimensão social do envelhecimento no grupo dos muito idosos, com ênfase especial nos centenários, permite apresentar as especificidades que as relações sociais assumem nesta fase da vida, bem como reconhecer o seu valor adaptativo, enquanto estratégia de compensação de per...

  14. A influência interpessoal e o engajamento na prática de esportes

    OpenAIRE

    Wagner Junior Ladeira; Tito Luciano Hermes Grillo; Fernando de Oliveira Santini; Clecio Falcão Araujo

    2013-01-01

    Fenômenos de engajamento no esporte têm detido a atenção de diversos gestores e pesquisadores da área de marketing, tendo em vista os benefícios de comportamentos de consumo contínuo e de dedicação ao objeto de engajamento que consumidores comprometidos manifestam. A fim de atender a uma crescente demanda por um entendimento mais sólido sobre questões de engajamento, o objetivo deste artigo é analisar a influência interpessoal como antecedente do engajamento em práticas esportivas...

  15. O Passado Negro : a incorporação da memória negra da cidade de Campinas através das performances de legados musicais

    OpenAIRE

    Erica Giesbrecht

    2011-01-01

    Resumo: A crescente proliferação de grupos performáticos, que, através de manifestações culturais, divulgam "passados", convencionalmente chamados de "tradições culturais", tem rendido estudos e debates no campo da etnomusicologia em todo o mundo. Partindo da etnografia de grupos de cultura popular afro-brasileira sediados na cidade de Campinas - São Paulo, proponho uma reflexão sobre as dinâmicas que particularizam tal processo ali. No auge da economia cafeeira do Brasil no século XIX, a cid...

  16. Avaliação do compartilhamento das memórias cache no desempenho de arquiteturas multi-core

    OpenAIRE

    Marco Antonio Zanata Alves

    2009-01-01

    No atual contexto de inovações em multi-core, em que as novas tecnologias de integração estão fornecendo um número crescente de transistores por chip, o estudo de técnicas de aumento de vazão de dados é de suma importância para os atuais e futuros processadores multi-core e many-core. Com a contínua demanda por desempenho computacional, as memórias cache vêm sendo largamente adotadas nos diversos tipos de projetos arquiteturais de computadores. Os atuais processadores disponíveis no mercado a...

  17. Utilização de resinas de troca-iônica em efluentes de galvanoplastia.

    OpenAIRE

    Josiane Costa Riani

    2008-01-01

    A crescente industrialização acompanhada do uso de metais pesados nos processos industriais nas últimas décadas resultou num aumento da contaminação do meio ambiente, principalmente em ambientes aquáticos. Assim, sendo a água um recurso natural de suma importância para a vida, métodos de tratamento de efluentes tornam-se indispensáveis para empresas geradoras de efluentes. O objetivo desse trabalho é a utilização de um sistema de troca iônica constituído por micro-colunas de resinas catiônica...

  18. Isolamento, caracterização e avaliação da atividade fotossensibilizadora de cumarinas e furanocumarinas extraídas de espécies de Citrus

    OpenAIRE

    Letícia Fracarolli

    2015-01-01

    O crescente aumento da tolerância aos fungicidas atualmente utilizados é um dos principais problemas tanto na área clínica quanto na agrícola e tem estimulado o desenvolvimento de estratégias alternativas para o controle de fungos patogênicos, tais como o tratamento fotodinâmico antimicrobiano (TFA), que pode utilizar fotossensibilizadores (FS) de origem natural ou sintética. Alguns FS, como as cumarinas e furanocumarinas, são produzidos por espécies de Citrus como limão Tahiti (Citrus latifo...

  19. Utilização das ferramentas JIT, MRP II e OPT como estratégia na redução de custos em indústria de fitoterápicos

    OpenAIRE

    Barretto, André Renato; Unesp - Universidade Estadual Paulista

    2013-01-01

    RESUMO Seguindo uma nova tendência mundial, o segmento farmacêutico passa a reforçar seus investimentos na área de tecnologia de industrialização do natural, ou seja, o fitoterápico. O uso de produtos fitoterápicos  tem apresentado uma crescente expansão, devido ao seu potencial de prevenção e com menos efeitos colaterais. Para que essas indústrias alcancem vantagem competitiva, é primordial a adoção de ferramentas como Just in Time, Manufacturing Resources Planning e Optimized Production ...

  20. Photopolymerization of complex emulsions with irregular shapes fabricated by multiplex coaxial flow focusing

    Science.gov (United States)

    Wu, Qiang; Yang, Chaoyu; Yang, Jianxin; Huang, Fangsheng; Liu, Guangli; Zhu, Zhiqiang; Si, Ting; Xu, Ronald X.

    2018-02-01

    We fabricate complex emulsions with irregular shapes in the microscale by a simple but effective multiplex coaxial flow focusing process. A multiphase cone-jet structure is steadily formed, and the compound liquid jet eventually breaks up into Janus microdroplets due to the perturbations propagating along the jet interfaces. The microdroplet shapes can be exclusively controlled by interfacial tensions of adjacent phases. Crescent-moon-shaped microparticles and microcapsules with designated structural characteristics are further produced under ultraviolet light of photopolymerization after removing one hemisphere of the Janus microdroplets. These complex emulsions have potential applications in bioscience, food, functional materials, and controlled drug delivery.

  1. Basaltic lava flows covering active aeolian dunes in the Paraná Basin in southern Brazil: Features and emplacement aspects

    Science.gov (United States)

    Waichel, Breno L.; Scherer, Claiton M. S.; Frank, Heinrich T.

    2008-03-01

    Burial of active aeolian dunes by lava flows can preserve the morphology of the dunes and generate diverse features related to interaction between unconsolidated sediments and lavas. In the study area, located in southern Brazil, burial of aeolian deposits by Cretaceous basaltic lava flows completely preserved dunes, and generate sand-deformation features, sand diapirs and peperite-like breccia. The preserved dunes are crescentic and linear at the main contact with basalts, and smaller crescentic where interlayered with lavas. The various feature types formed on sediment surfaces by the advance of the flows reflect the emplacement style of the lavas which are compound pahoehoe type. Four feature types can be recognized: (a) type 1 features are related to the advance of sheet flows in dune-interdune areas with slopes > 5°, (b) type 2 is formed where the lava flows advance in lobes and climb the stoss slope of crescentic dunes (slopes 8-12°), (c) type 3 is generated by toes that descend the face of linear dunes (slopes 17-23°) and (d) type 4 occurs when lava lobes descend the stoss slope of crescentic dunes (slopes 10-15°). The direction of the flows, the disposition and morphology of the dunes and the ground slope are the main factors controlling formation of the features. The injection of unconsolidated sand in lava lobes forms diapirs and peperite-like breccias. Sand diapirs occur at the basal portion of lobes where the lava was more solidified. Peperite-like breccias occur in the inner portion where lava was more plastic, favoring the mingling of the components. The generation of both features is related to a mechanical process: the weight of the lava causes the injection of sand into the lava and the warming of the air in the pores of the sand facilitates this process. The lava-sediment interaction features presented here are consistent with previous reports of basalt lavas with unconsolidated arid sediments, and additional new sand-deformation features

  2. Uma conversa (intemporal acerca do papel dos Centros Urbanos no âmbito de processos de planeamento desenvolvidos em colaboração

    Directory of Open Access Journals (Sweden)

    Viviana Lorenzo

    2012-10-01

    Full Text Available A crescente procura, por parte da sociedade civil, de uma maior participação no planeamento urbano tem vindo a incentivar novas formas de interacção entre o público e o privado. Os autores avançam algumas ideias acerca das presentes contradições e das potencialidades ainda não exploradas dos Centros Urbanos, partindo da Outlook Tower de Patrick Geddes até aos actuais Centros de Arquitectura enquanto instrumentos para o co‑planeamento de uma visão partilhada das cidades do futuro.

  3. Ergonomia no ambiente construído de instituições para idosos: estudos de caso em instituição brasileira e portuguesa

    OpenAIRE

    Paiva, Marie Monique Bruère

    2012-01-01

    O crescente processo de envelhecimento populacional de países em desenvolvimento, como o Brasil, juntamente com a busca por alternativas de moradia em instituições, conduz à necessidade de se investigar a adequabilidade dos ambientes construídos. Os espaços devem acolher com propriedade as mudanças de ordem física, cognitiva e emocional ocasionadas pelo processo de senescência e/ou senilidade das pessoas. Sendo o envelhecimento saudável aquele com envolvimento ativo com a vida e tendo como me...

  4. Caracterização físico-química de PET ramificado e de suas blendas com PET reciclado

    OpenAIRE

    Lucas Del Prette

    2004-01-01

    A crescente preocupação com a gestão de resíduos sólidos, observada na última década, em virtude de sua enorme quantidade e impacto ambiental, tem motivado a busca por processos de reciclagem, onde estes resíduos podem ser reprocessados de modo a gerarem novos produtos, ampliando o ciclo dos materiais e energia neles contidos. Especial atenção tem sido dada para a reciclagem do poli (tereftalato de etileno), PET, advindo de embalagens de bebidas carbonatadas. Durante a reciclagem do PET a açã...

  5. A estratégia internacional na produção e transferência do conhecimento dentro das multinacionais

    OpenAIRE

    Ribeiro, Tânia Rodrigues; Coelho, Joaquim José Vieira Pinto

    2014-01-01

    Lusíada. Economia & empresa. - ISSN 1645-6750. - S. 2, n. 15 (2012). - p. 43-57. Se há alguns anos se defendia que o sucesso das multinacionais residia na sua capacidade de exportar boas práticas para as suas filiais, com a crescente competitividade à escala mundial torna-se evidente a necessidade de as multinacionais construírem uma rede que permita a circulação de aprendizagens e conhecimentos entre filiais. A competitividade das multinacionais reside atualmente na sua capacidade de apre...

  6. Engagement at work; well-beging at work and psychological capital: a study in professionals in people management

    OpenAIRE

    Cavalcante, Marcileide Muniz

    2013-01-01

    É crescente a busca pelo engajamento no trabalho por se tratar de um construto motivacional positivo, caracterizado por vigor, dedicação e absorção, sempre relacionado ao trabalho, implicando sentimento de realização que envolve estado cognitivo positivo e que é persistente no tempo. A busca em conhecer o que gera sentimentos positivos em trabalhadores no ambiente de trabalho é tema corrente em diversos estudos na área do comportamento organizacional. O construto de bem-estar no trabalho é co...

  7. Liga de magnésio como material para bateria de alta densidade energética

    OpenAIRE

    Munhoz, Igor Polezi

    2014-01-01

    Orientador: Prof. Dr. Jorge Tomioka Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Engenharia Elétrica, 2014. No contexto energético, as mudanças climáticas e as crescentes crises energéticas aumentaram as preocupações e as pesquisas na área de acumuladores de energia, visando alcançar melhorias no cenário energético e ambiental global. Ao mesmo tempo, a sociedade tornou-se dependente do consumo de energia elétrica, sendo que falhas no fornec...

  8. Auxílio direto para fins de investigação criminal: novos parâmetros para a cooperação jurídica internacional

    OpenAIRE

    Kibrit, Orly

    2013-01-01

    Analisa a necessidade de que, no contexto da globalização, sejam intensificadas e fortalecidas as relações intergovernamentais por meio da cooperação jurídica internacional. Trata da necessidade de se promover mudanças na implementação desse instrumento no combate à crescente criminalidade internacional, demonstrando a imperatividade de uma revisão sobre os conceitos de soberania e cidadania, institutos que devem acompanhar o movimento da globalização e da internacionalização do direito, real...

  9. Estereótipos da Migração Produzidos pelo Discurso da Mídia Impressa Nacional - 10.5102/uri.v3i2.280

    Directory of Open Access Journals (Sweden)

    Irmã Eléia Scariot

    2007-09-01

    Full Text Available O presente trabalho analisa o discurso jornalístico da mídia impressa nacional em relação à migração, demonstrando a influência da globalização no crescente fluxo migratório forçado. No desenvolver deste artigo, tenta-se mostrar que o discurso dos mass media é resultado do pensamento da elite dominante que contribui na criação de estereótipos pejorativos acerca do migrante, sobretudo quando pertence ao grupo dos excluídos pelo sistema hegemônico vigente.

  10. “Bons pais” : representações e significações de pais hétero e homossexuais

    OpenAIRE

    Oliveira, Ana Catarina Dinis

    2012-01-01

    Dissertação de mestrado em Psicologia Clínica e da Saúde (Psicopatologia e Psicoterapias Dinâmicas) apresentada à Faculdade de Psicologia e Ciências da Educação da Universidade de Coimbra As sociedades ocidentais têm presenciado grandes alterações nos arranjos familiares, pelo que se verificam múltiplos tipos de família, incluindo as famílias homossexuais. Consequentemente, a parentalidade homossexual tornou-se num fenómeno presente e crescente nas sociedades modernas, gerando ...

  11. Reaproveitamento do resíduo de gesso na execução de revestimento interno de vedação vertical

    OpenAIRE

    Tavares, Yêda Vieira Póvoas; Lordsleem Júnior, Alberto Casado; Schmitz, Italo Benjamin Telles Arruda; John, Vanderley Moacyr

    2010-01-01

    O gesso está sendo utilizado em larga escala como revestimento interno de paredes por ser um material barato e de alto desempenho. No entanto, há uma grande geração de resíduo, o que constitui um problema econômico e ambiental. Embora se observe um interesse crescente no uso desse resíduo como revestimento de vedação interna, há um grande desconhecimento a respeito de sua tecnologia de produção, bem como de seu comportamento. O objetivo desta pesquisa é estudar o desempenho desse material atr...

  12. Determinação das propriedades físicas e mecânicas do gesso reciclado proveniente de chapas de gesso acartonado

    OpenAIRE

    Erbs,A.; Nagalli,A.; Mymrine,V.; Carvalho,K. Q.

    2015-01-01

    Resumo A busca pela viabilidade técnica e econômica da reciclagem de resíduos na cadeia produtiva da construção civil vem atender às novas necessidades do setor de promover crescimento econômico integrado às necessidades sociais e ambientais. O crescente aumento do consumo das chapas de gesso acartonado carrega consigo o problema da geração dos resíduos de gesso, onde a falta de pesquisa e o descarte incorreto acaba destinando o resíduo gerado, na maioria das vezes, para aterros ou bota-foras...

  13. Caracteriza??es f?sica e qu?mica de res?duos s?lidos da cajucultura e avalia??o do potencial energ?tico em processos de convers?o t?rmica

    OpenAIRE

    Tavares, Priscilla Torquato

    2016-01-01

    O aumento da demanda energ?tica e a crescente necessidade de produ??o sustent?vel de energia tem mostrado a import?ncia da diversifica??o das fontes energ?ticas. A biomassa tem se destacado por suas caracter?sticas econ?micas, f?sicas e qu?micas, podendo ser considerada como a fonte energ?tica do futuro. Os res?duos agr?colas s?o uma forma de biomassa apropriada para produ??o energ?tica. A gera??o de res?duos proveniente do cultivo e beneficiamento do caju produziu em 2015, no ...

  14. Estrutura e gestão dos canais de distribuição na indústria de alimentos para cães e gatos (petfood)

    OpenAIRE

    Marcos Bernasconi

    2006-01-01

    Os animais de estimação, especialmente cães e gatos, possuem uma participação crescente nos lares e na convivência social, relacionando-se intensamente com seus proprietários e proporcionando momentos de prazer e alegria. O mercado de consumo de bens e serviços, para manutenção do estilo de vida destes animais, em especial sua alimentação, tem crescido em grande escala mundialmente e, especialmente, no Brasil. O acelerado crescimento do mercado de Petfood, as mudanças no compor...

  15. Pathways to nephron loss starting from glomerular diseases-insights from animal models.

    Science.gov (United States)

    Kriz, Wilhelm; LeHir, Michel

    2005-02-01

    Studies of glomerular diseases in animal models show that progression toward nephron loss starts with extracapillary lesions, whereby podocytes play the central role. If injuries remain bound within the endocapillary compartment, they will undergo recovery or be repaired by scaring. Degenerative, inflammatory and dysregulative mechanisms leading to nephron loss are distinguished. In addition to several other unique features, the dysregulative mechanisms leading to collapsing glomerulopathy are particular in that glomeruli and tubules are affected in parallel. In contrast, in degenerative and inflammatory diseases, tubular injury is secondary to glomerular lesions. In both of the latter groups of diseases, the progression starts in the glomerulus with the loss of the separation between the tuft and Bowman's capsule by forming cell bridges (parietal cells and/or podocytes) between the glomerular and the parietal basement membranes. Cell bridges develop into tuft adhesions to Bowman's capsule, which initiate the formation of crescents, either by misdirected filtration (proteinaceous crescents) or by epithelial cell proliferation (cellular crescents). Crescents may spread over the entire circumference of the glomerulus and, via the glomerulotubular junction, may extend onto the tubule. Two mechanisms concerning the transfer of a glomerular injury onto the tubulointerstitium are discussed: (1) direct encroachment of extracapillary lesions and (2) protein leakage into tubular urine, resulting in injury to the tubule and the interstitium. There is evidence that direct encroachment is the crucial mechanism. Progression of chronic renal disease is underlain by a vicious cycle which passes on the damage from lost and/or damaged nephrons to so far healthy nephrons. Presently, two mechanisms are discussed: (1) the loss of nephrons leads to compensatory mechanisms in the remaining nephrons (glomerular hypertension, hyperfiltration, hypertrophy) which increase their

  16. Relativistic hydrodynamic theory of heavy-ion collisions

    International Nuclear Information System (INIS)

    Amsden, A.A.; Bertsch, G.F.; Harlow, F.H.; Nix, J.R.

    1975-01-01

    By use of finite-difference methods the classical relativistic equations of motion for the head-on collision of two heavy nuclei are solved. For 16 O projectiles incident onto various targets at laboratory bombarding energies per nucleon less than or equal to2.1 GeV, curved shock waves develop. The target and projectile are deformed and compressed into crescents of revolution. This is followed by rarefaction waves and an overall expansion of the matter into a moderately wide distribution of angles

  17. Resistindo ao desenvolvimento neocolonial: a luta do povo de Andalgalá contra projetos megamineiros

    OpenAIRE

    Misoczky,Maria Ceci; Böhm,Steffen

    2013-01-01

    A América Latina vem experimentando uma nova era de declarada fé dos governos no mito do desenvolvimento, em articulação com a expansão de políticas extrativistas exportadoras em um contexto de renovada dependência. A face mais dramática do extrativismo na região tem sido a crescente presença de corporações mineiras transnacionais apoiadas por governos nacionais e regionais e por instituições internacionais financeiras e de apoio ao desenvolvimento, e intensamente resistidas por movimentos so...

  18. Um modelo de hipertexto para apoio ao ensino mediado pela Web

    OpenAIRE

    Willie Dresler Leiva

    2003-01-01

    Atualmente há uma demanda crescente por aplicações hipermídia baseadas na WWW (World Wide Web), conhecidas como WIS (Web Information Systems). Esse novo tipo de aplicação apresenta requisitos adicionais aos sistemas de software clássicos, o que resulta na necessidade de investigar modelos mais adequados para apoiar o seu desenvolvimento. Em especial, os sistemas para apoio ao EaD (Ensino a Distância) baseados na Web apresentam características e requisitos ainda mais específicos. Os modelos at...

  19. Apuração e análise de custos nas pequenas empresas da indústria do vestuário da cidade de Juiz de Fora (MG)

    OpenAIRE

    Horta, Eduardo Duarte

    2004-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção É cada vez mais significativa a contribuição das pequenas empresas ao contexto socioeconômico brasileiro. Os números deste setor da economia demonstram a sua importância crescente mas revelam também que apesar de ser grande o número de novas pequenas empresas criadas a cada ano, também é bastante elevado o número desses empreendimentos que não conseguem u...

  20. Estudo de dose adequada da droga RO42-1611 (Arteflene) no tratamento da malária por Plasmodium falciparum

    OpenAIRE

    SILVA, Rita do Socorro Uchôa

    1997-01-01

    A resistência crescente do P. falciparum aos antimaláricos habitualmente empregados, torna urgente a avaliação de novas drogas. O Ro 42-1611 é um antimalárico derivado da planta chinesa Arlabotrys uncinatus. Usado apenas na África em três trabalhos no tratamento da malária por P. falciparum, tem sua ação desconhecida em sul-americanos com esta doença. Apesar do efeito antimalárico ter sido comprovado, ainda não se encontrou a dose adequada para o tratamento supressivo do P. falciparum. Avalia...