WorldWideScience

Sample records for analytical tool development

  1. Developing a learning analytics tool

    DEFF Research Database (Denmark)

    Wahl, Christian; Belle, Gianna; Clemmensen, Anita Lykke

    This poster describes how learning analytics and collective intelligence can be combined in order to develop a tool for providing support and feedback to learners and teachers regarding students self-initiated learning activities.......This poster describes how learning analytics and collective intelligence can be combined in order to develop a tool for providing support and feedback to learners and teachers regarding students self-initiated learning activities....

  2. Cryogenic Propellant Feed System Analytical Tool Development

    Science.gov (United States)

    Lusby, Brian S.; Miranda, Bruno M.; Collins, Jacob A.

    2011-01-01

    The Propulsion Systems Branch at NASA s Lyndon B. Johnson Space Center (JSC) has developed a parametric analytical tool to address the need to rapidly predict heat leak into propellant distribution lines based on insulation type, installation technique, line supports, penetrations, and instrumentation. The Propellant Feed System Analytical Tool (PFSAT) will also determine the optimum orifice diameter for an optional thermodynamic vent system (TVS) to counteract heat leak into the feed line and ensure temperature constraints at the end of the feed line are met. PFSAT was developed primarily using Fortran 90 code because of its number crunching power and the capability to directly access real fluid property subroutines in the Reference Fluid Thermodynamic and Transport Properties (REFPROP) Database developed by NIST. A Microsoft Excel front end user interface was implemented to provide convenient portability of PFSAT among a wide variety of potential users and its ability to utilize a user-friendly graphical user interface (GUI) developed in Visual Basic for Applications (VBA). The focus of PFSAT is on-orbit reaction control systems and orbital maneuvering systems, but it may be used to predict heat leak into ground-based transfer lines as well. PFSAT is expected to be used for rapid initial design of cryogenic propellant distribution lines and thermodynamic vent systems. Once validated, PFSAT will support concept trades for a variety of cryogenic fluid transfer systems on spacecraft, including planetary landers, transfer vehicles, and propellant depots, as well as surface-based transfer systems. The details of the development of PFSAT, its user interface, and the program structure will be presented.

  3. Developing Healthcare Data Analytics APPs with Open Data Science Tools.

    Science.gov (United States)

    Hao, Bibo; Sun, Wen; Yu, Yiqin; Xie, Guotong

    2017-01-01

    Recent advances in big data analytics provide more flexible, efficient, and open tools for researchers to gain insight from healthcare data. Whilst many tools require researchers to develop programs with programming languages like Python, R and so on, which is not a skill set grasped by many researchers in the healthcare data analytics area. To make data science more approachable, we explored existing tools and developed a practice that can help data scientists convert existing analytics pipelines to user-friendly analytics APPs with rich interactions and features of real-time analysis. With this practice, data scientists can develop customized analytics pipelines as APPs in Jupyter Notebook and disseminate them to other researchers easily, and researchers can benefit from the shared notebook to perform analysis tasks or reproduce research results much more easily.

  4. Using complaints to enhance quality improvement: developing an analytical tool.

    Science.gov (United States)

    Hsieh, Sophie Yahui

    2012-01-01

    This study aims to construct an instrument for identifying certain attributes or capabilities that might enable healthcare staff to use complaints to improve service quality. PubMed and ProQuest were searched, which in turn expanded access to other literature. Three paramount dimensions emerged for healthcare quality management systems: managerial, operational, and technical (MOT). The paper reveals that the managerial dimension relates to quality improvement program infrastructure. It contains strategy, structure, leadership, people and culture. The operational dimension relates to implementation processes: organizational changes and barriers when using complaints to enhance quality. The technical dimension emphasizes the skills, techniques or information systems required to achieve successfully continuous quality improvement. The MOT model was developed by drawing from the relevant literature. However, individuals have different training, interests and experiences and, therefore, there will be variance between researchers when generating the MOT model. The MOT components can be the guidelines for examining whether patient complaints are used to improve service quality. However, the model needs testing and validating by conducting further research before becoming a theory. Empirical studies on patient complaints did not identify any analytical tool that could be used to explore how complaints can drive quality improvement. This study developed an instrument for identifying certain attributes or capabilities that might enable healthcare professionals to use complaints and improve service quality.

  5. Social Data Analytics Tool

    DEFF Research Database (Denmark)

    Hussain, Abid; Vatrapu, Ravi

    2014-01-01

    This paper presents the design, development and demonstrative case studies of the Social Data Analytics Tool, SODATO. Adopting Action Design Framework [1], the objective of SODATO [2] is to collect, store, analyze, and report big social data emanating from the social media engagement of and social...... media conversations about organizations. We report and discuss results from two demonstrative case studies that were conducted using SODATO and conclude with implications and future work....

  6. Harnessing scientific literature reports for pharmacovigilance. Prototype software analytical tool development and usability testing.

    Science.gov (United States)

    Sorbello, Alfred; Ripple, Anna; Tonning, Joseph; Munoz, Monica; Hasan, Rashedul; Ly, Thomas; Francis, Henry; Bodenreider, Olivier

    2017-03-22

    We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers' capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management. We leveraged Medical Subject Heading (MeSH) indexing terms assigned to published citations in PubMed/MEDLINE to generate candidate drug-adverse event pairs for quantitative data mining. Six FDA regulatory reviewers participated in usability testing by employing the tool as part of their ongoing real-life pharmacovigilance activities to provide subjective feedback on its practical impact, added value, and fitness for use. All usability test participants cited the tool's ease of learning, ease of use, and generation of quantitative ADE safety signals, some of which corresponded to known established adverse drug reactions. Potential concerns included the comparability of the tool's automated literature search relative to a manual 'all fields' PubMed search, missing drugs and adverse event terms, interpretation of signal scores, and integration with existing computer-based analytical tools. Usability testing demonstrated that this novel tool can automate the detection of ADE safety signals from published literature reports. Various mitigation strategies are described to foster improvements in design, productivity, and end user satisfaction.

  7. Development of a Suite of Analytical Tools for Energy and Water Infrastructure Knowledge Discovery

    Science.gov (United States)

    Morton, A.; Piburn, J.; Stewart, R.; Chandola, V.

    2017-12-01

    Energy and water generation and delivery systems are inherently interconnected. With demand for energy growing, the energy sector is experiencing increasing competition for water. With increasing population and changing environmental, socioeconomic, and demographic scenarios, new technology and investment decisions must be made for optimized and sustainable energy-water resource management. This also requires novel scientific insights into the complex interdependencies of energy-water infrastructures across multiple space and time scales. To address this need, we've developed a suite of analytical tools to support an integrated data driven modeling, analysis, and visualization capability for understanding, designing, and developing efficient local and regional practices related to the energy-water nexus. This work reviews the analytical capabilities available along with a series of case studies designed to demonstrate the potential of these tools for illuminating energy-water nexus solutions and supporting strategic (federal) policy decisions.

  8. Development of computer-based analytical tool for assessing physical protection system

    International Nuclear Information System (INIS)

    Mardhi, Alim; Pengvanich, Phongphaeth

    2016-01-01

    Assessment of physical protection system effectiveness is the priority for ensuring the optimum protection caused by unlawful acts against a nuclear facility, such as unauthorized removal of nuclear materials and sabotage of the facility itself. Since an assessment based on real exercise scenarios is costly and time-consuming, the computer-based analytical tool can offer the solution for approaching the likelihood threat scenario. There are several currently available tools that can be used instantly such as EASI and SAPE, however for our research purpose it is more suitable to have the tool that can be customized and enhanced further. In this work, we have developed a computer–based analytical tool by utilizing the network methodological approach for modelling the adversary paths. The inputs are multi-elements in security used for evaluate the effectiveness of the system’s detection, delay, and response. The tool has capability to analyze the most critical path and quantify the probability of effectiveness of the system as performance measure

  9. Development of computer-based analytical tool for assessing physical protection system

    Energy Technology Data Exchange (ETDEWEB)

    Mardhi, Alim, E-mail: alim-m@batan.go.id [National Nuclear Energy Agency Indonesia, (BATAN), PUSPIPTEK area, Building 80, Serpong, Tangerang Selatan, Banten (Indonesia); Chulalongkorn University, Faculty of Engineering, Nuclear Engineering Department, 254 Phayathai Road, Pathumwan, Bangkok Thailand. 10330 (Thailand); Pengvanich, Phongphaeth, E-mail: ppengvan@gmail.com [Chulalongkorn University, Faculty of Engineering, Nuclear Engineering Department, 254 Phayathai Road, Pathumwan, Bangkok Thailand. 10330 (Thailand)

    2016-01-22

    Assessment of physical protection system effectiveness is the priority for ensuring the optimum protection caused by unlawful acts against a nuclear facility, such as unauthorized removal of nuclear materials and sabotage of the facility itself. Since an assessment based on real exercise scenarios is costly and time-consuming, the computer-based analytical tool can offer the solution for approaching the likelihood threat scenario. There are several currently available tools that can be used instantly such as EASI and SAPE, however for our research purpose it is more suitable to have the tool that can be customized and enhanced further. In this work, we have developed a computer–based analytical tool by utilizing the network methodological approach for modelling the adversary paths. The inputs are multi-elements in security used for evaluate the effectiveness of the system’s detection, delay, and response. The tool has capability to analyze the most critical path and quantify the probability of effectiveness of the system as performance measure.

  10. Development of computer-based analytical tool for assessing physical protection system

    Science.gov (United States)

    Mardhi, Alim; Pengvanich, Phongphaeth

    2016-01-01

    Assessment of physical protection system effectiveness is the priority for ensuring the optimum protection caused by unlawful acts against a nuclear facility, such as unauthorized removal of nuclear materials and sabotage of the facility itself. Since an assessment based on real exercise scenarios is costly and time-consuming, the computer-based analytical tool can offer the solution for approaching the likelihood threat scenario. There are several currently available tools that can be used instantly such as EASI and SAPE, however for our research purpose it is more suitable to have the tool that can be customized and enhanced further. In this work, we have developed a computer-based analytical tool by utilizing the network methodological approach for modelling the adversary paths. The inputs are multi-elements in security used for evaluate the effectiveness of the system's detection, delay, and response. The tool has capability to analyze the most critical path and quantify the probability of effectiveness of the system as performance measure.

  11. Development of the oil spill response cost-effectiveness analytical tool

    International Nuclear Information System (INIS)

    Etkin, D.S.; Welch, J.

    2005-01-01

    Decision-making during oil spill response operations or contingency planning requires balancing the need to remove as much oil as possible from the environment with the desire to minimize the impact of response operations on the environment they are intended to protect. This paper discussed the creation of a computer tool developed to help in planning and decision-making during response operations. The Oil Spill Response Cost-Effectiveness Analytical Tool (OSRCEAT) was developed to compare the costs of response with the benefits of response in both hypothetical and actual oil spills. The computer-based analytical tool can assist responders and contingency planners in decision-making processes as well as act as a basis of discussion in the evaluation of response options. Using inputs on spill parameters, location and response options, OSRCEAT can calculate response cost, costs of environmental and socioeconomic impacts of the oil spill and response impacts. Oil damages without any response are contrasted to oil damages with response, with expected improvements. Response damages are subtracted from the difference in damages with and without response in order to derive a more accurate response benefit. An OSRCEAT user can test various response options to compare potential benefits in order to maximize response benefit. OSRCEAT is best used to compare and contrast the relative benefits and costs of various response options. 50 refs., 19 tabs., 2 figs

  12. FIGURED WORLDS AS AN ANALYTIC AND METHODOLOGICAL TOOL IN PROFESSIONAL TEACHER DEVELOPMENT

    DEFF Research Database (Denmark)

    Møller, Hanne; Brok, Lene Storgaard

    . Hasse (2015) and Holland (1998) have inspired our study; i.e., learning is conceptualized as a social phenomenon, implying that contexts of learning are decisive for learner identity. The concept of Figured Worlds is used to understand the development and the social constitution of emergent interactions......,“(Holland et al., 1998, p. 52) and gives a framework for understanding meaning-making in particular pedagogical settings. We exemplify our use of the term Figured Worlds, both as an analytic and methodological tool for empirical studies in kindergarten and school. Based on data sources, such as field notes...

  13. Biosensors: Future Analytical Tools

    Directory of Open Access Journals (Sweden)

    Vikas

    2007-02-01

    Full Text Available Biosensors offer considerable promises for attaining the analytic information in a faster, simpler and cheaper manner compared to conventional assays. Biosensing approach is rapidly advancing and applications ranging from metabolite, biological/ chemical warfare agent, food pathogens and adulterant detection to genetic screening and programmed drug delivery have been demonstrated. Innovative efforts, coupling micromachining and nanofabrication may lead to even more powerful devices that would accelerate the realization of large-scale and routine screening. With gradual increase in commercialization a wide range of new biosensors are thus expected to reach the market in the coming years.

  14. A Review on the Design Structure Matrix as an Analytical Tool for Product Development Management

    OpenAIRE

    Mokudai, Takefumi

    2006-01-01

    This article reviews fundamental concepts and analytical techniques of design structure matrix (DSM) as well as recent development of DSM studies. The DSM is a matrix representation of relationships between components of a complex system, such as products, development organizations and processes. Depending on targets of analysis, there are four basic types of DSM: Component-based DSM, Team-based DSM, Task-based DSM, and Parameter-based DSM. There are two streams of recent DSM studies: 1) ...

  15. Program to develop analytical tools for environmental and safety assessment of nuclear material shipping container systems

    International Nuclear Information System (INIS)

    Butler, T.A.

    1978-11-01

    This paper describes a program for developing analytical techniques to evaluate the response of nuclear material shipping containers to severe accidents. Both lumped-mass and finite element techniques are employed to predict shipping container and shipping container-carrier response to impact. The general impact problem is computationally expensive because of its nonlinear, three-dimensional nature. This expense is minimized by using approximate models to parametrically identify critical cases before more exact analyses are performed. The computer codes developed for solving the problem are being experimentally substantiated with test data from full-scale and scale-model container drop tests. 6 figures, 1 table

  16. The Rack-Gear Tool Generation Modelling. Non-Analytical Method Developed in CATIA, Using the Relative Generating Trajectories Method

    Science.gov (United States)

    Teodor, V. G.; Baroiu, N.; Susac, F.; Oancea, N.

    2016-11-01

    The modelling of a curl of surfaces associated with a pair of rolling centrodes, when it is known the profile of the rack-gear's teeth profile, by direct measuring, as a coordinate matrix, has as goal the determining of the generating quality for an imposed kinematics of the relative motion of tool regarding the blank. In this way, it is possible to determine the generating geometrical error, as a base of the total error. The generation modelling allows highlighting the potential errors of the generating tool, in order to correct its profile, previously to use the tool in machining process. A method developed in CATIA is proposed, based on a new method, namely the method of “relative generating trajectories”. They are presented the analytical foundation, as so as some application for knows models of rack-gear type tools used on Maag teething machines.

  17. Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool.

    Science.gov (United States)

    Yan, Binjun; Chen, Teng; Xu, Zhilin; Qu, Haibin

    2014-06-01

    The concept of quality by design (QbD) is widely applied in the process development of pharmaceuticals. However, the additional cost and time have caused some resistance about QbD implementation. To show a possible solution, this work proposed a rapid process development method, which used direct analysis in real time mass spectrometry (DART-MS) as a process analytical technology (PAT) tool for studying the chromatographic process of Ginkgo biloba L., as an example. The breakthrough curves were fast determined by DART-MS at-line. A high correlation coefficient of 0.9520 was found between the concentrations of ginkgolide A determined by DART-MS and HPLC. Based on the PAT tool, the impacts of process parameters on the adsorption capacity were discovered rapidly, which showed a decreased adsorption capacity with the increase of the flow rate. This work has shown the feasibility and advantages of integrating PAT into QbD implementation for rapid process development. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. SRL online Analytical Development

    International Nuclear Information System (INIS)

    Jenkins, C.W.

    1991-01-01

    The Savannah River Site is operated by the Westinghouse Savannah River Co. for the Department of Energy to produce special nuclear materials for defense. R ampersand D support for site programs is provided by the Savannah River Laboratory, which I represent. The site is known primarily for its nuclear reactors, but actually three fourths of the efforts at the site are devoted to fuel/target fabrication, fuel/target reprocessing, and waste management. All of these operations rely heavily on chemical processes. The site is therefore a large chemical plant. There are then many potential applications for process analytical chemistry at SRS. The Savannah River Laboratory (SRL) has an Analytical Development Section of roughly 65 personnel that perform analyses for R ampersand D efforts at the lab, act as backup to the site Analytical Laboratories Department and develop analytical methods and instruments. I manage a subgroup of the Analytical Development Section called the Process Control ampersand Analyzer Development Group. The Prime mission of this group is to develop online/at-line analytical systems for site applications

  19. Development of reliable analytical tools for evaluating the influence of reductive winemaking on the quality of Lugana wines.

    Science.gov (United States)

    Mattivi, Fulvio; Fedrizzi, Bruno; Zenato, Alberto; Tiefenthaler, Paolo; Tempesta, Silvano; Perenzoni, Daniele; Cantarella, Paolo; Simeoni, Federico; Vrhovsek, Urska

    2012-06-30

    This paper presents methods for the definition of important analytical tools, such as the development of sensitive and rapid methods for analysing reduced and oxidised glutathione (GSH and GSSG), hydroxycinnamic acids (HCA), bound thiols (GSH-3MH and Cys-3MH) and free thiols (3MH and 3MHA), and their first application to evaluate the effect of reductive winemaking on the composition of Lugana juices and wines. Lugana is a traditional white wine from the Lake Garda region (Italy), produced using a local grape variety, Trebbiano di Lugana. An innovative winemaking procedure based on preliminary cooling of grape berries followed by crushing in an inert environment was implemented and explored on a winery scale. The effects of these procedures on hydroxycinnamic acids, GSH, GSSG, free and bound thiols and flavanols content were investigated. The juices and wines produced using different protocols were examined. Moreover, wines aged in tanks for 1, 2 and 3 months were analysed. The high level of GSH found in Lugana grapes, which can act as a natural antioxidant and be preserved in must and young wines, thus reducing the need of exogenous antioxidants, was particularly interesting. Moreover, it was clear that polyphenol concentrations (hydroxycinnamic acids and catechins) were strongly influenced by winemaking and pressing conditions, which required fine tuning of pressing. Above-threshold levels of 3-mercaptohexan-1-ol (3MH) and 3-mercaptohexyl acetate (3MHA) were found in the wines and changed according to the winemaking procedure applied. Interestingly, the evolution during the first three months also varied depending on the procedure adopted. Organic synthesis of cysteine and glutathione conjugates was carried out and juices and wines were subjected to LC-MS/MS analysis. These two molecules appeared to be strongly affected by the winemaking procedure, but did not show any significant change during the first 3 months of post-bottling ageing. This supports the theory

  20. Analytical Web Tool for CERES Products

    Science.gov (United States)

    Mitrescu, C.; Chu, C.; Doelling, D.

    2012-12-01

    The CERES project provides the community climate quality observed TOA fluxes, consistent cloud properties, and computed profile and surface fluxes. The 11-year long data set proves invaluable for remote sensing and climate modeling communities for annual global mean energy, meridianal heat transport, consistent cloud and fluxes and climate trends studies. Moreover, a broader audience interested in Earth's radiative properties such as green energy, health and environmental companies have showed their interest in CERES derived products. A few years ago, the CERES team start developing a new web-based Ordering Tool tailored for this wide diversity of users. Recognizing the potential that web-2.0 technologies can offer to both Quality Control (QC) and scientific data visualization and manipulation, the CERES team began introducing a series of specialized functions that addresses the above. As such, displaying an attractive, easy to use modern web-based format, the Ordering Tool added the following analytical functions: i) 1-D Histograms to display the distribution of the data field to identify outliers that are useful for QC purposes; ii) an "Anomaly" map that shows the regional differences between the current month and the climatological monthly mean; iii) a 2-D Histogram that can identify either potential problems with the data (i.e. QC function) or provides a global view of trends and/or correlations between various CERES flux, cloud, aerosol, and atmospheric properties. The large volume and diversity of data, together with the on-the-fly execution were the main challenges that had to be tackle with. Depending on the application, the execution was done on either the browser side or the server side with the help of auxiliary files. Additional challenges came from the use of various open source applications, the multitude of CERES products and the seamless transition from previous development. For the future, we plan on expanding the analytical capabilities of the

  1. Developments in analytical instrumentation

    Science.gov (United States)

    Petrie, G.

    The situation regarding photogrammetric instrumentation has changed quite dramatically over the last 2 or 3 years with the withdrawal of most analogue stereo-plotting machines from the market place and their replacement by analytically based instrumentation. While there have been few new developments in the field of comparators, there has been an explosive development in the area of small, relatively inexpensive analytical stereo-plotters based on the use of microcomputers. In particular, a number of new instruments have been introduced by manufacturers who mostly have not been associated previously with photogrammetry. Several innovative concepts have been introduced in these small but capable instruments, many of which are aimed at specialised applications, e.g. in close-range photogrammetry (using small-format cameras); for thematic mapping (by organisations engaged in environmental monitoring or resources exploitation); for map revision, etc. Another innovative and possibly significant development has been the production of conversion kits to convert suitable analogue stereo-plotting machines such as the Topocart, PG-2 and B-8 into fully fledged analytical plotters. The larger and more sophisticated analytical stereo-plotters are mostly being produced by the traditional mainstream photogrammetric systems suppliers with several new instruments and developments being introduced at the top end of the market. These include the use of enlarged photo stages to handle images up to 25 × 50 cm format; the complete integration of graphics workstations into the analytical plotter design; the introduction of graphics superimposition and stereo-superimposition; the addition of correlators for the automatic measurement of height, etc. The software associated with this new analytical instrumentation is now undergoing extensive re-development with the need to supply photogrammetric data as input to the more sophisticated G.I.S. systems now being installed by clients, instead

  2. Analytical tools in accelerator physics

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.N.

    2010-09-01

    This paper is a sub-set of my lectures presented in the Accelerator Physics course (USPAS, Santa Rosa, California, January 14-25, 2008). It is based on my notes I wrote during period from 1976 to 1979 in Novosibirsk. Only few copies (in Russian) were distributed to my colleagues in Novosibirsk Institute of Nuclear Physics. The goal of these notes is a complete description starting from the arbitrary reference orbit, explicit expressions for 4-potential and accelerator Hamiltonian and finishing with parameterization with action and angle variables. To a large degree follow logic developed in Theory of Cyclic Particle Accelerators by A.A.Kolmensky and A.N.Lebedev [Kolomensky], but going beyond the book in a number of directions. One of unusual feature is these notes use of matrix function and Sylvester formula for calculating matrices of arbitrary elements. Teaching the USPAS course motivated me to translate significant part of my notes into the English. I also included some introductory materials following Classical Theory of Fields by L.D. Landau and E.M. Liftsitz [Landau]. A large number of short notes covering various techniques are placed in the Appendices.

  3. Analytical tools in accelerator physics

    International Nuclear Information System (INIS)

    Litvinenko, V.N.

    2010-01-01

    This paper is a sub-set of my lectures presented in the Accelerator Physics course (USPAS, Santa Rosa, California, January 14-25, 2008). It is based on my notes I wrote during period from 1976 to 1979 in Novosibirsk. Only few copies (in Russian) were distributed to my colleagues in Novosibirsk Institute of Nuclear Physics. The goal of these notes is a complete description starting from the arbitrary reference orbit, explicit expressions for 4-potential and accelerator Hamiltonian and finishing with parameterization with action and angle variables. To a large degree follow logic developed in Theory of Cyclic Particle Accelerators by A.A.Kolmensky and A.N.Lebedev (Kolomensky), but going beyond the book in a number of directions. One of unusual feature is these notes use of matrix function and Sylvester formula for calculating matrices of arbitrary elements. Teaching the USPAS course motivated me to translate significant part of my notes into the English. I also included some introductory materials following Classical Theory of Fields by L.D. Landau and E.M. Liftsitz (Landau). A large number of short notes covering various techniques are placed in the Appendices.

  4. Leningrad NPP full scope and analytical simulators as tools for MMI improvement and operator support systems development and testing

    International Nuclear Information System (INIS)

    Rakitin, I.D.; Malkin, S.D.; Shalia, V.V.; Fedorov, E.M.; Lebedev, N.N.; Khoudiakov, M.M.

    1999-01-01

    Training Support Center (TSC) created at the Leningrad NPP (LNPP), Sosnovy Bor, Russia, incorporates full-scope and analytical simulators working in parallel with the prototypes of the expert and interactive systems to provide a new scope of R and D MMI improvement work as for the developer as well as for the user. Possibilities of development, adjusting and testing of any new or up-graded Operators' Support System before its installation at the reference unit's Control Room are described in the paper. These Simulators ensure the modeling of a wide range of accidents and transients and provide with special software and ETHERNET data process communications with the Operators' Support systems' prototypes. The development and adjustment of two state-of-the-art Operators' Support Systems of interest with using of Simulators are described in the paper as an example. These systems have been developed jointly by RRC KI and LNPP team. (author)

  5. Public Interest Energy Research (PIER) Program Development of a Computer-based Benchmarking and Analytical Tool. Benchmarking and Energy & Water Savings Tool in Dairy Plants (BEST-Dairy)

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Tengfang [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Flapper, Joris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ke, Jing [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kramer, Klaas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sathaye, Jayant [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-02-01

    The overall goal of the project is to develop a computer-based benchmarking and energy and water savings tool (BEST-Dairy) for use in the California dairy industry - including four dairy processes - cheese, fluid milk, butter, and milk powder. BEST-Dairy tool developed in this project provides three options for the user to benchmark each of the dairy product included in the tool, with each option differentiated based on specific detail level of process or plant, i.e., 1) plant level; 2) process-group level, and 3) process-step level. For each detail level, the tool accounts for differences in production and other variables affecting energy use in dairy processes. The dairy products include cheese, fluid milk, butter, milk powder, etc. The BEST-Dairy tool can be applied to a wide range of dairy facilities to provide energy and water savings estimates, which are based upon the comparisons with the best available reference cases that were established through reviewing information from international and national samples. We have performed and completed alpha- and beta-testing (field testing) of the BEST-Dairy tool, through which feedback from voluntary users in the U.S. dairy industry was gathered to validate and improve the tool's functionality. BEST-Dairy v1.2 was formally published in May 2011, and has been made available for free downloads from the internet (i.e., http://best-dairy.lbl.gov). A user's manual has been developed and published as the companion documentation for use with the BEST-Dairy tool. In addition, we also carried out technology transfer activities by engaging the dairy industry in the process of tool development and testing, including field testing, technical presentations, and technical assistance throughout the project. To date, users from more than ten countries in addition to those in the U.S. have downloaded the BEST-Dairy from the LBNL website. It is expected that the use of BEST-Dairy tool will advance understanding of energy and

  6. Development of a Computer-based Benchmarking and Analytical Tool. Benchmarking and Energy & Water Savings Tool in Dairy Plants (BEST-Dairy)

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Tengfang [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Flapper, Joris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ke, Jing [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kramer, Klaas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sathaye, Jayant [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-02-01

    The overall goal of the project is to develop a computer-based benchmarking and energy and water savings tool (BEST-Dairy) for use in the California dairy industry – including four dairy processes – cheese, fluid milk, butter, and milk powder.

  7. Guidance for the Design and Adoption of Analytic Tools.

    Energy Technology Data Exchange (ETDEWEB)

    Bandlow, Alisa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    The goal is to make software developers aware of common issues that can impede the adoption of analytic tools. This paper provides a summary of guidelines, lessons learned and existing research to explain what is currently known about what analysts want and how to better understand what tools they do and don't need.

  8. Development of simulation tools for improvement of measurement accuracy and efficiency in ultrasonic testing. Part 2. Development of fast simulator based on analytical approach

    International Nuclear Information System (INIS)

    Yamada, Hisao; Fukutomi, Hiroyuki; Lin, Shan; Ogata, Takashi

    2008-01-01

    CRIEPI developed a high speed simulation method to predict B scope images for crack-like defects under ultrasonic testing. This method is based on the geometrical theory of diffraction (GTD) to follow ultrasonic waves transmitted from the angle probe and with the aid of reciprocity relations to find analytical equations to express echoes received by the probe. The tip and mirror echoes from a slit with an arbitrary angle in the direction of thickness of test article and an arbitrary depth can be calculated by this method. Main object of the study is to develop a high speed simulation tool to gain B scope displays from the crack-like defect. This was achieved for the simple slits in geometry change regions by the prototype software based on the method. Fairy complete B scope images for slits could be obtained by about a minute on a current personal computer. The numerical predictions related to the surface opening slits were in excellent agreement with the relative experimental measurements. (author)

  9. Database and Analytical Tool Development for the Management of Data Derived from US DOE (NETL) Funded Fine Particulate (PM2.5) Research

    Energy Technology Data Exchange (ETDEWEB)

    Robinson P. Khosah; Frank T. Alex

    2007-02-11

    Advanced Technology Systems, Inc. (ATS) was contracted by the U. S. Department of Energy's National Energy Technology Laboratory (DOE-NETL) to develop a state-of-the-art, scalable and robust web-accessible database application to manage the extensive data sets resulting from the DOE-NETL-sponsored ambient air monitoring programs in the upper Ohio River valley region. The data management system was designed to include a web-based user interface that will allow easy access to the data by the scientific community, policy- and decision-makers, and other interested stakeholders, while providing detailed information on sampling, analytical and quality control parameters. In addition, the system will provide graphical analytical tools for displaying, analyzing and interpreting the air quality data. The system will also provide multiple report generation capabilities and easy-to-understand visualization formats that can be utilized by the media and public outreach/educational institutions. The project is being conducted in two phases. Phase One includes the following tasks: (1) data inventory/benchmarking, including the establishment of an external stakeholder group; (2) development of a data management system; (3) population of the database; (4) development of a web-based data retrieval system, and (5) establishment of an internal quality assurance/quality control system on data management. Phase Two, which is currently underway, involves the development of a platform for on-line data analysis. Phase Two includes the following tasks: (1) development of a sponsor and stakeholder/user website with extensive online analytical tools; (2) development of a public website; (3) incorporation of an extensive online help system into each website; and (4) incorporation of a graphical representation (mapping) system into each website. The project is now into its forty-eighth month of development activities.

  10. DATABASE AND ANALYTICAL TOOL DEVELOPMENT FOR THE MANAGEMENT OF DATA DERIVED FROM US DOE (NETL) FUNDED FINE PARTICULATE (PM2.5) RESEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Robinson P. Khosah; Charles G. Crawford

    2003-03-13

    Advanced Technology Systems, Inc. (ATS) was contracted by the U. S. Department of Energy's National Energy Technology Laboratory (DOE-NETL) to develop a state-of-the-art, scalable and robust web-accessible database application to manage the extensive data sets resulting from the DOE-NETL-sponsored ambient air monitoring programs in the upper Ohio River valley region. The data management system was designed to include a web-based user interface that will allow easy access to the data by the scientific community, policy- and decision-makers, and other interested stakeholders, while providing detailed information on sampling, analytical and quality control parameters. In addition, the system will provide graphical analytical tools for displaying, analyzing and interpreting the air quality data. The system will also provide multiple report generation capabilities and easy-to-understand visualization formats that can be utilized by the media and public outreach/educational institutions. The project is being conducted in two phases. Phase 1, which is currently in progress and will take twelve months to complete, will include the following tasks: (1) data inventory/benchmarking, including the establishment of an external stakeholder group; (2) development of a data management system; (3) population of the database; (4) development of a web-based data retrieval system, and (5) establishment of an internal quality assurance/quality control system on data management. In Phase 2, which will be completed in the second year of the project, a platform for on-line data analysis will be developed. Phase 2 will include the following tasks: (1) development of a sponsor and stakeholder/user website with extensive online analytical tools; (2) development of a public website; (3) incorporation of an extensive online help system into each website; and (4) incorporation of a graphical representation (mapping) system into each website. The project is now into its sixth month of Phase

  11. Database and Analytical Tool Development for the Management of Data Derived from US DOE (NETL) Funded Fine Particulate (PM2.5) Research

    Energy Technology Data Exchange (ETDEWEB)

    Robinson Khosah

    2007-07-31

    Advanced Technology Systems, Inc. (ATS) was contracted by the U. S. Department of Energy's National Energy Technology Laboratory (DOE-NETL) to develop a state-of-the-art, scalable and robust web-accessible database application to manage the extensive data sets resulting from the DOE-NETL-sponsored ambient air monitoring programs in the upper Ohio River valley region. The data management system was designed to include a web-based user interface that will allow easy access to the data by the scientific community, policy- and decision-makers, and other interested stakeholders, while providing detailed information on sampling, analytical and quality control parameters. In addition, the system will provide graphical analytical tools for displaying, analyzing and interpreting the air quality data. The system will also provide multiple report generation capabilities and easy-to-understand visualization formats that can be utilized by the media and public outreach/educational institutions. The project was conducted in two phases. Phase One included the following tasks: (1) data inventory/benchmarking, including the establishment of an external stakeholder group; (2) development of a data management system; (3) population of the database; (4) development of a web-based data retrieval system, and (5) establishment of an internal quality assurance/quality control system on data management. Phase Two involved the development of a platform for on-line data analysis. Phase Two included the following tasks: (1) development of a sponsor and stakeholder/user website with extensive online analytical tools; (2) development of a public website; (3) incorporation of an extensive online help system into each website; and (4) incorporation of a graphical representation (mapping) system into each website. The project is now technically completed.

  12. A new tool for the evaluation of the analytical procedure: Green Analytical Procedure Index.

    Science.gov (United States)

    Płotka-Wasylka, J

    2018-05-01

    A new means for assessing analytical protocols relating to green analytical chemistry attributes has been developed. The new tool, called GAPI (Green Analytical Procedure Index), evaluates the green character of an entire analytical methodology, from sample collection to final determination, and was created using such tools as the National Environmental Methods Index (NEMI) or Analytical Eco-Scale to provide not only general but also qualitative information. In GAPI, a specific symbol with five pentagrams can be used to evaluate and quantify the environmental impact involved in each step of an analytical methodology, mainly from green through yellow to red depicting low, medium to high impact, respectively. The proposed tool was used to evaluate analytical procedures applied in the determination of biogenic amines in wine samples, and polycyclic aromatic hydrocarbon determination by EPA methods. GAPI tool not only provides an immediately perceptible perspective to the user/reader but also offers exhaustive information on evaluated procedures. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Developing an analytical tool for evaluating EMS system design changes and their impact on cardiac arrest outcomes: combining geographic information systems with register data on survival rates

    Directory of Open Access Journals (Sweden)

    Sund Björn

    2013-02-01

    Full Text Available Abstract Background Out-of-hospital cardiac arrest (OHCA is a frequent and acute medical condition that requires immediate care. We estimate survival rates from OHCA in the area of Stockholm, through developing an analytical tool for evaluating Emergency Medical Services (EMS system design changes. The study also is an attempt to validate the proposed model used to generate the outcome measures for the study. Methods and results This was done by combining a geographic information systems (GIS simulation of driving times with register data on survival rates. The emergency resources comprised ambulance alone and ambulance plus fire services. The simulation model predicted a baseline survival rate of 3.9 per cent, and reducing the ambulance response time by one minute increased survival to 4.6 per cent. Adding the fire services as first responders (dual dispatch increased survival to 6.2 per cent from the baseline level. The model predictions were validated using empirical data. Conclusion We have presented an analytical tool that easily can be generalized to other regions or countries. The model can be used to predict outcomes of cardiac arrest prior to investment in EMS design changes that affect the alarm process, e.g. (1 static changes such as trimming the emergency call handling time or (2 dynamic changes such as location of emergency resources or which resources should carry a defibrillator.

  14. Analytical Tools for Space Suit Design

    Science.gov (United States)

    Aitchison, Lindsay

    2011-01-01

    As indicated by the implementation of multiple small project teams within the agency, NASA is adopting a lean approach to hardware development that emphasizes quick product realization and rapid response to shifting program and agency goals. Over the past two decades, space suit design has been evolutionary in approach with emphasis on building prototypes then testing with the largest practical range of subjects possible. The results of these efforts show continuous improvement but make scaled design and performance predictions almost impossible with limited budgets and little time. Thus, in an effort to start changing the way NASA approaches space suit design and analysis, the Advanced Space Suit group has initiated the development of an integrated design and analysis tool. It is a multi-year-if not decadal-development effort that, when fully implemented, is envisioned to generate analysis of any given space suit architecture or, conversely, predictions of ideal space suit architectures given specific mission parameters. The master tool will exchange information to and from a set of five sub-tool groups in order to generate the desired output. The basic functions of each sub-tool group, the initial relationships between the sub-tools, and a comparison to state of the art software and tools are discussed.

  15. Artist - analytical RT inspection simulation tool

    International Nuclear Information System (INIS)

    Bellon, C.; Jaenisch, G.R.

    2007-01-01

    The computer simulation of radiography is applicable for different purposes in NDT such as for the qualification of NDT systems, the prediction of its reliability, the optimization of system parameters, feasibility analysis, model-based data interpretation, education and training of NDT/NDE personnel, and others. Within the framework of the integrated project FilmFree the radiographic testing (RT) simulation software developed by BAM is being further developed to meet practical requirements for inspection planning in digital industrial radiology. It combines analytical modelling of the RT inspection process with the CAD-orientated object description applicable to various industrial sectors such as power generation, railways and others. (authors)

  16. Analytical framework and tool kit for SEA follow-up

    International Nuclear Information System (INIS)

    Nilsson, Mans; Wiklund, Hans; Finnveden, Goeran; Jonsson, Daniel K.; Lundberg, Kristina; Tyskeng, Sara; Wallgren, Oskar

    2009-01-01

    Most Strategic Environmental Assessment (SEA) research and applications have so far neglected the ex post stages of the process, also called SEA follow-up. Tool kits and methodological frameworks for engaging effectively with SEA follow-up have been conspicuously missing. In particular, little has so far been learned from the much more mature evaluation literature although many aspects are similar. This paper provides an analytical framework and tool kit for SEA follow-up. It is based on insights and tools developed within programme evaluation and environmental systems analysis. It is also grounded in empirical studies into real planning and programming practices at the regional level, but should have relevance for SEA processes at all levels. The purpose of the framework is to promote a learning-oriented and integrated use of SEA follow-up in strategic decision making. It helps to identify appropriate tools and their use in the process, and to systematise the use of available data and knowledge across the planning organization and process. It distinguishes three stages in follow-up: scoping, analysis and learning, identifies the key functions and demonstrates the informational linkages to the strategic decision-making process. The associated tool kit includes specific analytical and deliberative tools. Many of these are applicable also ex ante, but are then used in a predictive mode rather than on the basis of real data. The analytical element of the framework is organized on the basis of programme theory and 'DPSIR' tools. The paper discusses three issues in the application of the framework: understanding the integration of organizations and knowledge; understanding planners' questions and analytical requirements; and understanding interests, incentives and reluctance to evaluate

  17. Commentary on "Theory-Led Design of Instruments and Representations in Learning Analytics: Developing a Novel Tool for Orchestration of Online Collaborative Learning"

    Science.gov (United States)

    Teplovs, Chris

    2015-01-01

    This commentary reflects on the contributions to learning analytics and theory by a paper that describes how multiple theoretical frameworks were woven together to inform the creation of a new, automated discourse analysis tool. The commentary highlights the contributions of the original paper, provides some alternative approaches, and touches on…

  18. Development of a new analytical tool for assessing the mutagen 2-methyl-1,4-dinitro-pyrrole in meat products by LC-ESI-MS/MS.

    Science.gov (United States)

    Molognoni, Luciano; Daguer, Heitor; de Sá Ploêncio, Leandro Antunes; Yotsuyanagi, Suzana Eri; da Silva Correa Lemos, Ana Lucia; Joussef, Antonio Carlos; De Dea Lindner, Juliano

    2018-08-01

    The use of sorbate and nitrite in meat processing may lead to the formation of 2-methyl-1,4-dinitro-pyrrole (DNMP), a mutagenic compound. This work was aimed at developing and validating an analytical method for the quantitation of DNMP by liquid chromatography-tandem mass spectrometry. Full validation was performed in accordance to Commission Decision 2002/657/EC and method applicability was checked in several samples of meat products. A simple procedure, with low temperature partitioning solid-liquid extraction, was developed. The nitrosation during the extraction was monitored by the N-nitroso-DL-pipecolic acid content. Chromatographic separation was achieved in 8 min with di-isopropyl-3-aminopropyl silane bound to hydroxylated silica as stationary phase. Samples of bacon and cooked sausage yielded the highest concentrations of DNMP (68 ± 3 and 50 ± 3 μg kg -1 , respectively). The developed method proved to be a reliable, selective, and sensitive tool for DNMP measurements in meat products. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. Evaluation of Linked Data tools for Learning Analytics

    NARCIS (Netherlands)

    Drachsler, Hendrik; Herder, Eelco; d'Aquin, Mathieu; Dietze, Stefan

    2013-01-01

    Drachsler, H., Herder, E., d'Aquin, M., & Dietze, S. (2013, 8-12 April). Evaluation of Linked Data tools for Learning Analytics. Presentation given in the tutorial on 'Using Linked Data for Learning Analytics' at LAK2013, the Third Conference on Learning Analytics and Knowledge, Leuven, Belgium.

  20. PIXE as an analytical/educational tool

    International Nuclear Information System (INIS)

    Williams, E.T.

    1991-01-01

    The advantages and disadvantages of PIXE as an analytical method will be summarized. The authors will also discuss the advantages of PIXE as a means of providing interesting and feasible research projects for undergraduate science students

  1. Analytical and numerical tools for vacuum systems

    CERN Document Server

    Kersevan, R

    2007-01-01

    Modern particle accelerators have reached a level of sophistication which require a thorough analysis of all their sub-systems. Among the latter, the vacuum system is often a major contributor to the operating performance of a particle accelerator. The vacuum engineer has nowadays a large choice of computational schemes and tools for the correct analysis, design, and engineering of the vacuum system. This paper is a review of the different type of algorithms and methodologies which have been developed and employed in the field since the birth of vacuum technology. The different level of detail between simple back-of-the-envelope calculations and more complex numerical analysis is discussed by means of comparisons. The domain of applicability of each method is discussed, together with its pros and cons.

  2. Method for effective usage of Google Analytics tools

    Directory of Open Access Journals (Sweden)

    Ирина Николаевна Егорова

    2016-01-01

    Full Text Available Modern Google Analytics tools have been investigated against effective attraction channels for users and bottlenecks detection. Conducted investigation allowed to suggest modern method for effective usage of Google Analytics tools. The method is based on main traffic indicators analysis, as well as deep analysis of goals and their consecutive tweaking. Method allows to increase website conversion and might be useful for SEO and Web analytics specialists

  3. Factors Influencing Beliefs for Adoption of a Learning Analytics Tool: An Empirical Study

    Science.gov (United States)

    Ali, Liaqat; Asadi, Mohsen; Gasevic, Dragan; Jovanovic, Jelena; Hatala, Marek

    2013-01-01

    Present research and development offer various learning analytics tools providing insights into different aspects of learning processes. Adoption of a specific tool for practice is based on how its learning analytics are perceived by educators to support their pedagogical and organizational goals. In this paper, we propose and empirically validate…

  4. A Tool Supporting Collaborative Data Analytics Workflow Design and Management

    Science.gov (United States)

    Zhang, J.; Bao, Q.; Lee, T. J.

    2016-12-01

    Collaborative experiment design could significantly enhance the sharing and adoption of the data analytics algorithms and models emerged in Earth science. Existing data-oriented workflow tools, however, are not suitable to support collaborative design of such a workflow, to name a few, to support real-time co-design; to track how a workflow evolves over time based on changing designs contributed by multiple Earth scientists; and to capture and retrieve collaboration knowledge on workflow design (discussions that lead to a design). To address the aforementioned challenges, we have designed and developed a technique supporting collaborative data-oriented workflow composition and management, as a key component toward supporting big data collaboration through the Internet. Reproducibility and scalability are two major targets demanding fundamental infrastructural support. One outcome of the project os a software tool, supporting an elastic number of groups of Earth scientists to collaboratively design and compose data analytics workflows through the Internet. Instead of recreating the wheel, we have extended an existing workflow tool VisTrails into an online collaborative environment as a proof of concept.

  5. Analytical Aerodynamic Simulation Tools for Vertical Axis Wind Turbines

    International Nuclear Information System (INIS)

    Deglaire, Paul

    2010-01-01

    Wind power is a renewable energy source that is today the fastest growing solution to reduce CO 2 emissions in the electric energy mix. Upwind horizontal axis wind turbine with three blades has been the preferred technical choice for more than two decades. This horizontal axis concept is today widely leading the market. The current PhD thesis will cover an alternative type of wind turbine with straight blades and rotating along the vertical axis. A brief overview of the main differences between the horizontal and vertical axis concept has been made. However the main focus of this thesis is the aerodynamics of the wind turbine blades. Making aerodynamically efficient turbines starts with efficient blades. Making efficient blades requires a good understanding of the physical phenomena and effective simulations tools to model them. The specific aerodynamics for straight bladed vertical axis turbine flow are reviewed together with the standard aerodynamic simulations tools that have been used in the past by blade and rotor designer. A reasonably fast (regarding computer power) and accurate (regarding comparison with experimental results) simulation method was still lacking in the field prior to the current work. This thesis aims at designing such a method. Analytical methods can be used to model complex flow if the geometry is simple. Therefore, a conformal mapping method is derived to transform any set of section into a set of standard circles. Then analytical procedures are generalized to simulate moving multibody sections in the complex vertical flows and forces experienced by the blades. Finally the fast semi analytical aerodynamic algorithm boosted by fast multipole methods to handle high number of vortices is coupled with a simple structural model of the rotor to investigate potential aeroelastic instabilities. Together with these advanced simulation tools, a standard double multiple streamtube model has been developed and used to design several straight bladed

  6. Game development tool essentials

    CERN Document Server

    Berinstein, Paula; Ardolino, Alessandro; Franco, Simon; Herubel, Adrien; McCutchan, John; Nedelcu, Nicusor; Nitschke, Benjamin; Olmstead, Don; Robinet, Fabrice; Ronchi, Christian; Turkowski, Rita; Walter, Robert; Samour, Gustavo

    2014-01-01

    Offers game developers new techniques for streamlining the critical game tools pipeline. Inspires game developers to share their secrets and improve the productivity of the entire industry. Helps game industry practitioners compete in a hyper-competitive environment.

  7. Electronic tongue: An analytical gustatory tool

    Directory of Open Access Journals (Sweden)

    Rewanthwar Swathi Latha

    2012-01-01

    Full Text Available Taste is an important organoleptic property governing acceptance of products for administration through mouth. But majority of drugs available are bitter in taste. For patient acceptability and compliance, bitter taste drugs are masked by adding several flavoring agents. Thus, taste assessment is one important quality control parameter for evaluating taste-masked formulations. The primary method for the taste measurement of drug substances and formulations is by human panelists. The use of sensory panelists is very difficult and problematic in industry and this is due to the potential toxicity of drugs and subjectivity of taste panelists, problems in recruiting taste panelists, motivation and panel maintenance are significantly difficult when working with unpleasant products. Furthermore, Food and Drug Administration (FDA-unapproved molecules cannot be tested. Therefore, analytical taste-sensing multichannel sensory system called as electronic tongue (e-tongue or artificial tongue which can assess taste have been replacing the sensory panelists. Thus, e-tongue includes benefits like reducing reliance on human panel. The present review focuses on the electrochemical concepts in instrumentation, performance qualification of E-tongue, and applications in various fields.

  8. Analytical Tools to Improve Optimization Procedures for Lateral Flow Assays

    Directory of Open Access Journals (Sweden)

    Helen V. Hsieh

    2017-05-01

    Full Text Available Immunochromatographic or lateral flow assays (LFAs are inexpensive, easy to use, point-of-care medical diagnostic tests that are found in arenas ranging from a doctor’s office in Manhattan to a rural medical clinic in low resource settings. The simplicity in the LFA itself belies the complex task of optimization required to make the test sensitive, rapid and easy to use. Currently, the manufacturers develop LFAs by empirical optimization of material components (e.g., analytical membranes, conjugate pads and sample pads, biological reagents (e.g., antibodies, blocking reagents and buffers and the design of delivery geometry. In this paper, we will review conventional optimization and then focus on the latter and outline analytical tools, such as dynamic light scattering and optical biosensors, as well as methods, such as microfluidic flow design and mechanistic models. We are applying these tools to find non-obvious optima of lateral flow assays for improved sensitivity, specificity and manufacturing robustness.

  9. Analytical Tools for the Routine Use of the UMAE

    International Nuclear Information System (INIS)

    D'Auria, F.; Eramo, A.; Gianotti, W.

    1998-01-01

    UMAE (Uncertainty Methodology based on Accuracy Extrapolation) is methodology developed to calculate the uncertainties related to thermal-hydraulic code results in Nuclear Power Plant transient analysis. The use of the methodology has shown the need of specific analytical tools to simplify some steps of its application and making clearer individual procedures adopted in the development. Three of these have been recently completed and are illustrated in this paper. The first one makes it possible to attribute ''weight factors'' to the experimental Integral Test Facilities; results are also shown. The second one deals with the calculation of the accuracy of a code results. The concerned computer program makes a comparison between experimental and calculated trends of any quantity and gives as output the accuracy of the calculation. The third one consists in a computer program suitable to get continuous uncertainty bands from single valued points. (author)

  10. FUMAC-84. A hybrid PCI analytical tool

    International Nuclear Information System (INIS)

    Matheson, J.E.; Walton, L.A.

    1984-01-01

    ''FUMAC-84'', a new computer code currently under development at Babcock and Wilcox, will be used to analyze PCMI in light water reactor fuel rods. This is a hybrid code in the sense that the pellet behaviour is predicted from deterministic models which incorporate the large data base being generated by the international fuel performance programs (OVERRAMP, SUPER-RAMP, NFIR, etc.), while the cladding is modelled using finite elements. The fuel cracking and relocation model developed for FUMAC is semi-empirical and includes data up to 35 GWd/mtU and linear heat rates ranging from 100 to 700 W/Cm. With this model the onset of cladding ridging has been accurately predicted for steady-state operation. Transient behaviour of the pellet is still under investigation and the model is being enhanced to include these effects. The cladding model integrates the mechanical damage over a power history by solving the finite element assumed displacement problem in a quasistatic manner. Early work on FUMAC-84 has been directed at the development and benchmarking of the interim code. The purpose of the interim code is to provide a vehicle to proof out the deterministic pellet models which have been developed. To date the cracking model and the relocation model have been benchmarked. The thermal model for the pellet was developed by fitting data from several Halden experiments. The ability to accurately predict cladding ridging behaviour has been used to test how well the pellet swelling, densification and compliance models work in conjunction with fuel cladding material models. Reasonable results have been achieved for the steady-state cases while difficulty has been encountered in trying to reproduce transient results. Current work includes an effort to improve the ability of the models to handle transients well. (author)

  11. Helicase-dependent isothermal amplification: a novel tool in the development of molecular-based analytical systems for rapid pathogen detection.

    Science.gov (United States)

    Barreda-García, Susana; Miranda-Castro, Rebeca; de-Los-Santos-Álvarez, Noemí; Miranda-Ordieres, Arturo J; Lobo-Castañón, María Jesús

    2018-01-01

    Highly sensitive testing of nucleic acids is essential to improve the detection of pathogens, which pose a major threat for public health worldwide. Currently available molecular assays, mainly based on PCR, have a limited utility in point-of-need control or resource-limited settings. Consequently, there is a strong interest in developing cost-effective, robust, and portable platforms for early detection of these harmful microorganisms. Since its description in 2004, isothermal helicase-dependent amplification (HDA) has been successfully applied in the development of novel molecular-based technologies for rapid, sensitive, and selective detection of viruses and bacteria. In this review, we highlight relevant analytical systems using this simple nucleic acid amplification methodology that takes place at a constant temperature and that is readily compatible with microfluidic technologies. Different strategies for monitoring HDA amplification products are described. In addition, we present technological advances for integrating sample preparation, HDA amplification, and detection. Future perspectives and challenges toward point-of-need use not only for clinical diagnosis but also in food safety testing and environmental monitoring are also discussed. Graphical Abstract Expanding the analytical toolbox for the detection of DNA sequences specific of pathogens with isothermal helicase dependent amplification (HDA).

  12. The use of generalised audit software by internal audit functions in a developing country: The purpose of the use of generalised audit software as a data analytics tool

    Directory of Open Access Journals (Sweden)

    D.P. van der Nest

    2017-11-01

    Full Text Available This article explores the purpose of the use of generalised audit software as a data analytics tool by internal audit functions in the locally controlled banking industry of South Africa. The evolution of the traditional internal audit methodology of collecting audit evidence through the conduct of interviews, the completion of questionnaires, and by testing controls on a sample basis, is long overdue, and such practice in the present technological, data-driven era will soon render such an internal audit function obsolete. The research results indicate that respondents are utilising GAS for a variety of purposes but that its frequency of use is not yet optimal and that there is still much room for improvement for tests of controls purposes. The top five purposes for which the respondents make use of GAS often to always during separate internal audit engagements are: (1 to identify transactions with specific characteristics or control criteria for tests of control purposes; (2 for conducting full population analysis; (3 to identify account balances over a certain amount; (4 to identify and report on the frequency of occurrence of risks or frequency of occurrence of specific events; and (5 to obtain audit evidence about control effectiveness

  13. Web analytics tools and web metrics tools: An overview and comparative analysis

    Directory of Open Access Journals (Sweden)

    Ivan Bekavac

    2015-10-01

    Full Text Available The aim of the paper is to compare and analyze the impact of web analytics tools for measuring the performance of a business model. Accordingly, an overview of web analytics and web metrics tools is given, including their characteristics, main functionalities and available types. The data acquisition approaches and proper choice of web tools for particular business models are also reviewed. The research is divided in two sections. First, a qualitative focus is placed on reviewing web analytics tools to exploring their functionalities and ability to be integrated into the respective business model. Web analytics tools support the business analyst’s efforts in obtaining useful and relevant insights into market dynamics. Thus, generally speaking, selecting a web analytics and web metrics tool should be based on an investigative approach, not a random decision. The second section is a quantitative focus shifting from theory to an empirical approach, and which subsequently presents output data resulting from a study based on perceived user satisfaction of web analytics tools. The empirical study was carried out on employees from 200 Croatian firms from either an either IT or marketing branch. The paper contributes to highlighting the support for management that available web analytics and web metrics tools available on the market have to offer, and based on the growing needs of understanding and predicting global market trends.

  14. Network analytical tool for monitoring global food safety highlights China.

    Directory of Open Access Journals (Sweden)

    Tamás Nepusz

    Full Text Available BACKGROUND: The Beijing Declaration on food safety and security was signed by over fifty countries with the aim of developing comprehensive programs for monitoring food safety and security on behalf of their citizens. Currently, comprehensive systems for food safety and security are absent in many countries, and the systems that are in place have been developed on different principles allowing poor opportunities for integration. METHODOLOGY/PRINCIPAL FINDINGS: We have developed a user-friendly analytical tool based on network approaches for instant customized analysis of food alert patterns in the European dataset from the Rapid Alert System for Food and Feed. Data taken from alert logs between January 2003-August 2008 were processed using network analysis to i capture complexity, ii analyze trends, and iii predict possible effects of interventions by identifying patterns of reporting activities between countries. The detector and transgressor relationships are readily identifiable between countries which are ranked using i Google's PageRank algorithm and ii the HITS algorithm of Kleinberg. The program identifies Iran, China and Turkey as the transgressors with the largest number of alerts. However, when characterized by impact, counting the transgressor index and the number of countries involved, China predominates as a transgressor country. CONCLUSIONS/SIGNIFICANCE: This study reports the first development of a network analysis approach to inform countries on their transgressor and detector profiles as a user-friendly aid for the adoption of the Beijing Declaration. The ability to instantly access the country-specific components of the several thousand annual reports will enable each country to identify the major transgressors and detectors within its trading network. Moreover, the tool can be used to monitor trading countries for improved detector/transgressor ratios.

  15. Analytical quality by design: a tool for regulatory flexibility and robust analytics.

    Science.gov (United States)

    Peraman, Ramalingam; Bhadraya, Kalva; Padmanabha Reddy, Yiragamreddy

    2015-01-01

    Very recently, Food and Drug Administration (FDA) has approved a few new drug applications (NDA) with regulatory flexibility for quality by design (QbD) based analytical approach. The concept of QbD applied to analytical method development is known now as AQbD (analytical quality by design). It allows the analytical method for movement within method operable design region (MODR). Unlike current methods, analytical method developed using analytical quality by design (AQbD) approach reduces the number of out-of-trend (OOT) results and out-of-specification (OOS) results due to the robustness of the method within the region. It is a current trend among pharmaceutical industry to implement analytical quality by design (AQbD) in method development process as a part of risk management, pharmaceutical development, and pharmaceutical quality system (ICH Q10). Owing to the lack explanatory reviews, this paper has been communicated to discuss different views of analytical scientists about implementation of AQbD in pharmaceutical quality system and also to correlate with product quality by design and pharmaceutical analytical technology (PAT).

  16. Risk assessment using Analytical Hierarchy Process - Development and evaluation of a new computer-based tool; Riskvaerdering med Analytical Hierarchy Process - Utveckling och utprovning av ett nytt datorbaserat verktyg

    Energy Technology Data Exchange (ETDEWEB)

    Ritchey, Tom (Swedish Defence Research Agency, Stockholm (Sweden))

    2008-11-15

    Risk analysis concerning the management of contaminated areas involves comparing and evaluating the relationship between ecological, technical, economic and other factors, in order to determine a reasonable level of remediation. Risk analysis of this kind is a relatively new phenomenon. In order to develop methodology in this area, the Sustainable Remediation program contributes both to comprehensive risk analysis projects and to projects concentrating on specific aspects of remediation risk analysis. In the project described in this report, the Swedish Defence Research Agency (FOI) was given a grant by the Sustainable Remediation program to apply the Analytic Hierarchy Process (AHP) in order to develop a computer-aided instrument to support remediation risk analysis. AHP is one of several so-called multi-criteria decision support methods. These methods are applied in order to systematically compare and evaluate different solutions or measures, when there are many different goal criteria involved. Such criteria can be both quantitative and qualitative. The project has resulted in the development of a computer-aided instrument which can be employed to give a better structure, consistency and traceability to risk analyses for the remediation of contaminated areas. Project was carried out in two phases with two different working groups. The first phase involved the development of a generic base-model for remediation risk analysis. This was performed by a 'development group'. The second phase entailed the testing of the generic model in a specific, on-going remediation project. This was performed by a 'test group'. The remediation project in question concerned the decontamination of a closed-down sawmill in Vaeckelsaang, in the Swedish municipality of Tingsryd

  17. Learning Analytics: drivers, developments and challenges

    Directory of Open Access Journals (Sweden)

    Rebecca Ferguson

    2014-12-01

    Full Text Available Learning analytics is a significant area of Technology-Enhanced Learning (TEL that has emerged during the last decade. This review of the field begins with an examination of the technological, educational and political factors that have driven the development of analytics in educational settings. It goes on to chart the emergence of learning analytics, including their origins in the 20th century, the development of data-driven analytics, the rise of learning-focused perspectives and the influence of national economic concerns. It next focuses on the relationships between learning analytics, educational data mining and academic analytics. Finally, it examines developing areas of learning analytics research, and identifies a series of future challenges.

  18. Big Data Analytics Tools as Applied to ATLAS Event Data

    CERN Document Server

    Vukotic, Ilija; The ATLAS collaboration

    2016-01-01

    Big Data technologies have proven to be very useful for storage, processing and visualization of derived metrics associated with ATLAS distributed computing (ADC) services. Log file data and database records, and metadata from a diversity of systems have been aggregated and indexed to create an analytics platform for ATLAS ADC operations analysis. Dashboards, wide area data access cost metrics, user analysis patterns, and resource utilization efficiency charts are produced flexibly through queries against a powerful analytics cluster. Here we explore whether these techniques and analytics ecosystem can be applied to add new modes of open, quick, and pervasive access to ATLAS event data so as to simplify access and broaden the reach of ATLAS public data to new communities of users. An ability to efficiently store, filter, search and deliver ATLAS data at the event and/or sub-event level in a widely supported format would enable or significantly simplify usage of big data, statistical and machine learning tools...

  19. Analytical Modelling Of Milling For Tool Design And Selection

    International Nuclear Information System (INIS)

    Fontaine, M.; Devillez, A.; Dudzinski, D.

    2007-01-01

    This paper presents an efficient analytical model which allows to simulate a large panel of milling operations. A geometrical description of common end mills and of their engagement in the workpiece material is proposed. The internal radius of the rounded part of the tool envelope is used to define the considered type of mill. The cutting edge position is described for a constant lead helix and for a constant local helix angle. A thermomechanical approach of oblique cutting is applied to predict forces acting on the tool and these results are compared with experimental data obtained from milling tests on a 42CrMo4 steel for three classical types of mills. The influence of some tool's geometrical parameters on predicted cutting forces is presented in order to propose optimisation criteria for design and selection of cutting tools

  20. Applications of Spatial Data Using Business Analytics Tools

    Directory of Open Access Journals (Sweden)

    Anca Ioana ANDREESCU

    2011-12-01

    Full Text Available This paper addresses the possibilities of using spatial data in business analytics tools, with emphasis on SAS software. Various kinds of map data sets containing spatial data are presented and discussed. Examples of map charts illustrating macroeconomic parameters demonstrate the application of spatial data for the creation of map charts in SAS Enterprise Guise. Extended features of map charts are being exemplified by producing charts via SAS programming procedures.

  1. Electrochemical sensors: a powerful tool in analytical chemistry

    Directory of Open Access Journals (Sweden)

    Stradiotto Nelson R.

    2003-01-01

    Full Text Available Potentiometric, amperometric and conductometric electrochemical sensors have found a number of interesting applications in the areas of environmental, industrial, and clinical analyses. This review presents a general overview of the three main types of electrochemical sensors, describing fundamental aspects, developments and their contribution to the area of analytical chemistry, relating relevant aspects of the development of electrochemical sensors in Brazil.

  2. Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymers

    DEFF Research Database (Denmark)

    Bose, Sanjukta; Schmid, Silvan; Larsen, Tom

    2014-01-01

    Resonant microstrings show promise as a new analytical tool for thermal characterization of polymers with only few nanograms of sample. The detection of the glass transition temperature (Tg) of an amorphous poly(d,l-lactide) (PDLLA) and a semicrystalline poly(l-lactide) (PLLA) is investigated....... The polymers are spray coated on one side of the resonating microstrings. The resonance frequency and quality factor (Q) are measured simultaneously as a function of temperature. Change in the resonance frequency reflects a change in static tensile stress, which yields information about the Young’s modulus...... of the polymer, and a change in Q reflects the change in damping of the polymer-coated string. The frequency response of the microstring is validated with an analytical model. From the frequency independent tensile stress change, static Tg values of 40.6 and 57.6 °C were measured for PDLLA and PLLA, respectively...

  3. Selecting analytical tools for characterization of polymersomes in aqueous solution

    DEFF Research Database (Denmark)

    Habel, Joachim Erich Otto; Ogbonna, Anayo; Larsen, Nanna

    2015-01-01

    Selecting the appropriate analytical methods for characterizing the assembly and morphology of polymer-based vesicles, or polymersomes are required to reach their full potential in biotechnology. This work presents and compares 17 different techniques for their ability to adequately report size....../purification. Of the analytical methods tested, Cryo-transmission electron microscopy and atomic force microscopy (AFM) turned out to be advantageous for polymersomes with smaller diameter than 200 nm, whereas confocal microscopy is ideal for diameters >400 nm. Polymersomes in the intermediate diameter range can be characterized...... using freeze fracture Cryo-scanning electron microscopy (FF-Cryo-SEM) and nanoparticle tracking analysis (NTA). Small angle X-ray scattering (SAXS) provides reliable data on bilayer thickness and internal structure, Cryo-TEM on multilamellarity. Taken together, these tools are valuable...

  4. Identity as an Analytical Tool to Explore Students’ Mathematical Writing

    DEFF Research Database (Denmark)

    Iversen, Steffen Møllegaard

    Learning to communicate in, with and about mathematics is a key part of learning mathematics (Niss & Højgaard, 2011). Therefore, understanding how students’ mathematical writing is shaped is important to mathematics education research. In this paper the notion of ‘writer identity’ (Ivanič, 1998; ......; Burgess & Ivanič, 2010) is introduced and operationalised in relation to students’ mathematical writing and through a case study it is illustrated how this analytic tool can facilitate valuable insights when exploring students’ mathematical writing....

  5. Selecting analytical tools for characterization of polymersomes in aqueous solution

    DEFF Research Database (Denmark)

    Habel, Joachim Erich Otto; Ogbonna, Anayo; Larsen, Nanna

    2015-01-01

    /purification. Of the analytical methods tested, Cryo-transmission electron microscopy and atomic force microscopy (AFM) turned out to be advantageous for polymersomes with smaller diameter than 200 nm, whereas confocal microscopy is ideal for diameters >400 nm. Polymersomes in the intermediate diameter range can be characterized...... using freeze fracture Cryo-scanning electron microscopy (FF-Cryo-SEM) and nanoparticle tracking analysis (NTA). Small angle X-ray scattering (SAXS) provides reliable data on bilayer thickness and internal structure, Cryo-TEM on multilamellarity. Taken together, these tools are valuable...

  6. Developing Foucault's Discourse Analytic Methodology

    Directory of Open Access Journals (Sweden)

    Rainer Diaz-Bone

    2006-01-01

    Full Text Available A methodological position for a FOUCAULTian discourse analysis is presented. A sequence of analytical steps is introduced and an illustrating example is offered. It is emphasized that discourse analysis has to discover the system-level of discursive rules and the deeper structure of the discursive formation. Otherwise the analysis will be unfinished. Michel FOUCAULTs work is theoretically grounded in French structuralism and (the so called post-structuralism. In this paper, post-structuralism is not conceived as a means for overcoming of structuralism, but as a way of critically continuing the structural perspective. In this way, discursive structures can be related to discursive practices and the concept of structure can be disclosed (e. g. to inter-discourse or DERRIDAs concept of structurality. In this way, the structural methodology is continued and radicalized, but not given up. In this paper, FOUCAULTs theory is combined with the works of Michel PÊCHEUX and (especially for the sociology of knowledge and the sociology of culture Pierre BOURDIEU. The practice of discourse analysis is theoretically grounded. This practice can be conceived as a reflexive coupling of deconstruction and reconstruction in the material to be analyzed. This methodology therefore can be characterized as a reconstructive qualitative methodology. At the end of the article, forms of discourse analysis are criticized that do not intend to recover the system level of discursive rules and that do not intend to discover the deeper structure of the discursive formation (i. e. episteme, socio-episteme. These forms merely are commentaries of discourses (not their analyses, they remain phenomenological and are therefore: pre-structuralist. URN: urn:nbn:de:0114-fqs060168

  7. Development and Verification of Behavior of Tritium Analytic Code (BOTANIC)

    International Nuclear Information System (INIS)

    Park, Min Young; Kim, Eung Soo

    2014-01-01

    VHTR, one of the Generation IV reactor concepts, has a relatively high operation temperature and is usually suggested as a heat source for many industrial processes, including hydrogen production process. Thus, it is vital to trace tritium behavior in the VHTR system and the potential permeation rate to the industrial process. In other words, tritium is a crucial issue in terms of safety in the fission reactor system. Therefore, it is necessary to understand the behavior of tritium and the development of the tool to enable this is vital.. In this study, a Behavior of Tritium Analytic Code (BOTANIC) an analytic tool which is capable of analyzing tritium behavior is developed using a chemical process code called gPROMS. BOTANIC was then further verified using the analytic solutions and benchmark codes such as Tritium Permeation Analysis Code (TPAC) and COMSOL. In this study, the Behavior of Tritium Analytic Code, BOTANIC, has been developed using a chemical process code called gPROMS. The code has several distinctive features including non-diluted assumption, flexible applications and adoption of distributed permeation model. Due to these features, BOTANIC has the capability to analyze a wide range of tritium level systems and has a higher accuracy as it has the capacity to solve distributed models. BOTANIC was successfully developed and verified using analytical solution and the benchmark code calculation result. The results showed very good agreement with the analytical solutions and the calculation results of TPAC and COMSOL. Future work will be focused on the total system verification

  8. Process analytical technology (PAT) tools for the cultivation step in biopharmaceutical production

    NARCIS (Netherlands)

    Streefland, M.; Martens, D.E.; Beuvery, E.C.; Wijffels, R.H.

    2013-01-01

    The process analytical technology (PAT) initiative is now 10 years old. This has resulted in the development of many tools and software packages dedicated to PAT application on pharmaceutical processes. However, most applications are restricted to small molecule drugs, mainly for the relatively

  9. Current research relevant to the improvement of γ-ray spectroscopy as an analytical tool

    International Nuclear Information System (INIS)

    Meyer, R.A.; Tirsell, K.G.; Armantrout, G.A.

    1976-01-01

    Four areas of research that will have significant impact on the further development of γ-ray spectroscopy as an accurate analytical tool are considered. The areas considered are: (1) automation; (2) accurate multigamma ray sources; (3) accuracy of the current and future γ-ray energy scale, and (4) new solid state X and γ-ray detectors

  10. Development of Nuclear Analytical Technology

    International Nuclear Information System (INIS)

    Park, Yong Joon; Kim, J. Y.; Sohn, S. C.

    2007-06-01

    The pre-treatment and handling techniques for the micro-particles in swipe samples were developed for the safeguards purpose. The development of screening technique for the swipe samples has been established using the nuclear fission track method as well as the alpha track method. The laser ablation system to take a nuclear particle present in swipe was designed and constructed for the determination of the enrichment factors for uranium or plutonium, and its performance was tested in atmosphere as well as in vacuum. The optimum conditions for the synthesis of silica based micro-particles were obtained for mass production. The optimum ion exchange resin was selected and the optimum conditions for the uranium adsorption in resin bead technique were established for the development of the enrichment factor for nuclear particles in swipe. The established technique was applied to the swipe taken directly from the nuclear facility and also to the archive samples of IAEA's environmental swipes. The evaluation of dose rate of neutron and secondary gamma-ray for the radiation shields were carried out to design the NIPS system, as well as the evaluation of the thermal neutron concentration effect by the various reflectors. D-D neutron generator was introduced as a neutron source for the NIPS system to have more advantages such as easier control and moderation capability than the 252 Cf source. Simulated samples for explosive and chemical warfare were prepared to construct a prompt gamma-ray database. Based on the constructed database, a computer program for the detection of illicit chemical and nuclear materials was developed using the MATLAB software

  11. Development of Nuclear Analytical Technology

    Energy Technology Data Exchange (ETDEWEB)

    Park, Yong Joon; Kim, J. Y.; Sohn, S. C. (and others)

    2007-06-15

    The pre-treatment and handling techniques for the micro-particles in swipe samples were developed for the safeguards purpose. The development of screening technique for the swipe samples has been established using the nuclear fission track method as well as the alpha track method. The laser ablation system to take a nuclear particle present in swipe was designed and constructed for the determination of the enrichment factors for uranium or plutonium, and its performance was tested in atmosphere as well as in vacuum. The optimum conditions for the synthesis of silica based micro-particles were obtained for mass production. The optimum ion exchange resin was selected and the optimum conditions for the uranium adsorption in resin bead technique were established for the development of the enrichment factor for nuclear particles in swipe. The established technique was applied to the swipe taken directly from the nuclear facility and also to the archive samples of IAEA's environmental swipes. The evaluation of dose rate of neutron and secondary gamma-ray for the radiation shields were carried out to design the NIPS system, as well as the evaluation of the thermal neutron concentration effect by the various reflectors. D-D neutron generator was introduced as a neutron source for the NIPS system to have more advantages such as easier control and moderation capability than the {sup 252}Cf source. Simulated samples for explosive and chemical warfare were prepared to construct a prompt gamma-ray database. Based on the constructed database, a computer program for the detection of illicit chemical and nuclear materials was developed using the MATLAB software.

  12. 33 CFR 385.33 - Revisions to models and analytical tools.

    Science.gov (United States)

    2010-07-01

    ... on a case-by-case basis what documentation is appropriate for revisions to models and analytic tools... analytical tools. 385.33 Section 385.33 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE... Incorporating New Information Into the Plan § 385.33 Revisions to models and analytical tools. (a) In carrying...

  13. Development of nuclear analytical technology

    International Nuclear Information System (INIS)

    Jee, Kwang Yong; Kim, W. H.; Park, Yeong J.; Park, Yong J.; Sohn, S. C.; Song, B. C.; Jeon, Y. S.; Pyo, H. Y.; Ha, Y. K.

    2004-04-01

    The objectives of this study are to develop the technology for the determination of isotopic ratios of nuclear particles detected from swipe samples and to develop the NIPS system. The R and D contents and results of this study are firstly the production of nuclear micro particle(1 ∼ 20 μm) and standardization, the examination of variation in fission track characteristic according to nuclear particle size and enrichment( 235 U: 1-50%), the construction of database and the application of this technique to swipe samples. If this technique is verified its superiority by various field tests and inter-laboratory comparison program with other institutes in developed countries, it can be possible to join NWAL supervised under IAEA and to export our technology abroad. Secondly, characteristics of alpha track by boron (n, α) nuclear reaction were studied to measure both total boron concentration and 10B enrichment. The correlation of number of alpha tracks and various 10B concentration was studied to evaluate the reliability of this method. Especially, cadmium shielding technique was introduced to reduce the background of alpha tracks by covering the solid track detector and the multi-dot detector plate was developed to increase the reproducibility of measurement by making boron solution dried evenly in the plate. The results of the alpha track method were found to be well agreed with those of mass spectroscopy within less than 10 % deviation. Finally, the NIPS system using 252 Cf neutron source was developed and prompt gamma spectrum and its background were obtained. Monte Carlo method using MCNP-4B code was utilized for the interpretation of neutron and gamma-ray shielding condition as well as the moderation of a fast neutron. Gamma-gamma coincidence was introduced to reduce the prompt gamma background. The counting efficiency of the HPGe detector was calibrated in the energy range from 50 keV to 10 MeV using radio isotope standards and prompt gamma rays of Cl for the

  14. Analytical Tools for Functional Assessment of Architectural Layouts

    Science.gov (United States)

    Bąkowski, Jarosław

    2017-10-01

    Functional layout of the building, understood as a layout or set of the facility rooms (or groups of rooms) with a system of internal communication, creates an environment and a place of mutual relations between the occupants of the object. Achieving optimal (from the occupants’ point of view) spatial arrangement is possible through activities that often go beyond the stage of architectural design. Adopted in the architectural design, most often during trial and error process or on the basis of previous experience (evidence-based design), functional layout is subject to continuous evaluation and dynamic changing since the beginning of its use. Such verification of the occupancy phase allows to plan future, possible transformations, as well as to develop model solutions for use in other settings. In broader terms, the research hypothesis is to examine whether and how the collected datasets concerning the facility and its utilization can be used to develop methods for assessing functional layout of buildings. In other words, if it is possible to develop an objective method of assessing functional layouts basing on a set of buildings’ parameters: technical, technological and functional ones and whether the method allows developing a set of tools enhancing the design methodology of complex functional objects. By linking the design with the construction phase it is possible to build parametric models of functional layouts, especially in the context of sustainable design or lean design in every aspect: ecological (by reducing the property’s impact on environment), economic (by optimizing its cost) and social (through the implementation of high-performance work environment). Parameterization of size and functional connections of the facility become part of the analyses, as well as the element of model solutions. The “lean” approach means the process of analysis of the existing scheme and consequently - finding weak points as well as means for eliminating these

  15. Environmental tools in product development

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Hauschild, Michael Zwicky; Jørgensen, Jørgen

    1994-01-01

    A precondition for design of environmentally friendly products is that the design team has access to methods and tools supporting the introduction of environmental criteria in product development. A large Danish program, EDIP, is being carried out by the Institute for Product Development, Technical...... University of Denmark, in cooperation with 5 major Danish companies aiming at the development and testing of such tools. These tools are presented in this paper...

  16. Laser-induced plasma spectrometry: truly a surface analytical tool

    International Nuclear Information System (INIS)

    Vadillo, Jose M.; Laserna, J.

    2004-01-01

    For a long period, analytical applications of laser induced plasma spectrometry (LIPS) have been mainly restricted to overall and quantitative determination of elemental composition in bulk, solid samples. However, introduction of new compact and reliable solid state lasers and technological development in multidimensional intensified detectors have made possible the seeking of new analytical niches for LIPS where its analytical advantages (direct sampling from any material irrespective of its conductive status without sample preparation and with sensitivity adequate for many elements in different matrices) could be fully exploited. In this sense, the field of surface analysis could take advantage from the cited advantages taking into account in addition, the capability of LIPS for spot analysis, line scan, depth-profiling, area analysis and compositional mapping with a single instrument in air at atmospheric pressure. This review paper outlines the fundamental principles of laser-induced plasma emission relevant to sample surface studies, discusses the experimental parameters governing the spatial (lateral and in-depth) resolution in LIPS analysis and presents the applications concerning surface examination

  17. Web analytics as tool for improvement of website taxonomies

    DEFF Research Database (Denmark)

    Jonasen, Tanja Svarre; Ådland, Marit Kristine; Lykke, Marianne

    The poster examines how web analytics can be used to provide information about users and inform design and redesign of taxonomies. It uses a case study of the website Cancer.dk by the Danish Cancer Society. The society is a private organization with an overall goal to prevent the development...... provides information about e.g. subjects of interest, searching behaviour, browsing patterns in website structure as well as tag clouds, page views. The poster discusses benefits and challenges of the two web metrics, with a model of how to use search and tag data for the design of taxonomies, e.g. choice...

  18. Distributed Engine Control Empirical/Analytical Verification Tools

    Science.gov (United States)

    DeCastro, Jonathan; Hettler, Eric; Yedavalli, Rama; Mitra, Sayan

    2013-01-01

    NASA's vision for an intelligent engine will be realized with the development of a truly distributed control system featuring highly reliable, modular, and dependable components capable of both surviving the harsh engine operating environment and decentralized functionality. A set of control system verification tools was developed and applied to a C-MAPSS40K engine model, and metrics were established to assess the stability and performance of these control systems on the same platform. A software tool was developed that allows designers to assemble easily a distributed control system in software and immediately assess the overall impacts of the system on the target (simulated) platform, allowing control system designers to converge rapidly on acceptable architectures with consideration to all required hardware elements. The software developed in this program will be installed on a distributed hardware-in-the-loop (DHIL) simulation tool to assist NASA and the Distributed Engine Control Working Group (DECWG) in integrating DCS (distributed engine control systems) components onto existing and next-generation engines.The distributed engine control simulator blockset for MATLAB/Simulink and hardware simulator provides the capability to simulate virtual subcomponents, as well as swap actual subcomponents for hardware-in-the-loop (HIL) analysis. Subcomponents can be the communication network, smart sensor or actuator nodes, or a centralized control system. The distributed engine control blockset for MATLAB/Simulink is a software development tool. The software includes an engine simulation, a communication network simulation, control algorithms, and analysis algorithms set up in a modular environment for rapid simulation of different network architectures; the hardware consists of an embedded device running parts of the CMAPSS engine simulator and controlled through Simulink. The distributed engine control simulation, evaluation, and analysis technology provides unique

  19. Enhancing Safeguards through Information Analysis: Business Analytics Tools

    International Nuclear Information System (INIS)

    Vincent, J.; Midwinter, J.

    2015-01-01

    For the past 25 years the IBM i2 Intelligence Analysis product portfolio has assisted over 4,500 organizations across law enforcement, defense, government agencies, and commercial private sector businesses to maximize the value of the mass of information to discover and disseminate actionable intelligence that can help identify, investigate, predict, prevent, and disrupt criminal, terrorist, and fraudulent acts; safeguarding communities, organizations, infrastructures, and investments. The collaborative Intelligence Analysis environment delivered by i2 is specifically designed to be: · scalable: supporting business needs as well as operational and end user environments · modular: an architecture which can deliver maximum operational flexibility with ability to add complimentary analytics · interoperable: integrating with existing environments and eases information sharing across partner agencies · extendable: providing an open source developer essential toolkit, examples, and documentation for custom requirements i2 Intelligence Analysis brings clarity to complex investigations and operations by delivering industry leading multidimensional analytics that can be run on-demand across disparate data sets or across a single centralized analysis environment. The sole aim is to detect connections, patterns, and relationships hidden within high-volume, all-source data, and to create and disseminate intelligence products in near real time for faster informed decision making. (author)

  20. Android development tools for Eclipse

    CERN Document Server

    Shah, Sanjay

    2013-01-01

    A standard tutorial aimed at developing Android applications in a practical manner.Android Development Tools for Eclipse is aimed at beginners and existing developers who want to learn more about Android development. It is assumed that you have experience in Java programming and that you have used IDE for development.

  1. Prioritizing pesticide compounds for analytical methods development

    Science.gov (United States)

    Norman, Julia E.; Kuivila, Kathryn; Nowell, Lisa H.

    2012-01-01

    The U.S. Geological Survey (USGS) has a periodic need to re-evaluate pesticide compounds in terms of priorities for inclusion in monitoring and studies and, thus, must also assess the current analytical capabilities for pesticide detection. To meet this need, a strategy has been developed to prioritize pesticides and degradates for analytical methods development. Screening procedures were developed to separately prioritize pesticide compounds in water and sediment. The procedures evaluate pesticide compounds in existing USGS analytical methods for water and sediment and compounds for which recent agricultural-use information was available. Measured occurrence (detection frequency and concentrations) in water and sediment, predicted concentrations in water and predicted likelihood of occurrence in sediment, potential toxicity to aquatic life or humans, and priorities of other agencies or organizations, regulatory or otherwise, were considered. Several existing strategies for prioritizing chemicals for various purposes were reviewed, including those that identify and prioritize persistent, bioaccumulative, and toxic compounds, and those that determine candidates for future regulation of drinking-water contaminants. The systematic procedures developed and used in this study rely on concepts common to many previously established strategies. The evaluation of pesticide compounds resulted in the classification of compounds into three groups: Tier 1 for high priority compounds, Tier 2 for moderate priority compounds, and Tier 3 for low priority compounds. For water, a total of 247 pesticide compounds were classified as Tier 1 and, thus, are high priority for inclusion in analytical methods for monitoring and studies. Of these, about three-quarters are included in some USGS analytical method; however, many of these compounds are included on research methods that are expensive and for which there are few data on environmental samples. The remaining quarter of Tier 1

  2. Development of integrated analytical data management system

    International Nuclear Information System (INIS)

    Onishi, Koichi; Wachi, Isamu; Hiroki, Toshio

    1986-01-01

    The Analysis Subsection of Technical Service Section, Tokai Reprocessing Plant, Tokai Works, is engaged in analysis activities required for the management of processes and measurements in the plant. Currently, it has been desired to increase the reliability of analytical data and to perform analyses more rapidly to cope with the increasing number of analysis works. To meet this end, on-line data processing has been promoted and advanced analytical equipment has been introduced in order to enhance automization. In the present study, an integrated analytical data mangement system is developed which serves for improvement of reliability of analytical data as well as for rapid retrieval and automatic compilation of these data. Fabrication of a basic model of the system has been nearly completed and test operation has already been started. In selecting hardware to be used, examinations were made on easiness of system extension, Japanese language processing function for improving man-machine interface, large-capacity auxiliary memory system, and data base processing function. The existing analysis works wer reviewed in establishing the basic design of the system. According to this basic design, the system can perform such works as analysis of application slips received from clients as well as recording, sending, filing and retrieval of analysis results. (Nogami, K.)

  3. Ultrasonic trap as analytical tool; Die Ultraschallfalle als analytisches Werkzeug

    Energy Technology Data Exchange (ETDEWEB)

    Leiterer, Jork

    2009-11-30

    nanoparticles. This comprises fields of research like biomineralisation, protein agglomeration, distance dependent effects of nanocrystalline quantum dots and the in situ observation of early crystallization stages. In summary, the results of this work open a broad area of application to use the ultrasonic trap as an analytical tool. [German] Die Ultraschallfalle bietet eine besondere Moeglichkeit zur Handhabung von Proben im Mikrolitermassstab. Durch die akustische Levitation wird die Probe kontaktfrei in einer gasfoermigen Umgebung positioniert und somit dem Einfluss fester Oberflaechen entzogen. In dieser Arbeit werden die Moeglichkeiten der Ultraschallfalle fuer den Einsatz in der Analytik experimentell untersucht. Durch die Kopplung mit typischen kontaktlosen Analysemethoden wie der Spektroskopie und der Roentgenstreuung werden die Vorteile dieser Levitationstechnik an verschiedenen Materialien wie anorganischen, organischen, pharmazeutischen Substanzen bis hin zu Proteinen, Nano- und Mikropartikeln demonstriert. Es wird gezeigt, dass die Nutzung der akustischen Levitation zuverlaessig eine beruehrungslose Probenhandhabung fuer den Einsatz spektroskopischer Methoden (LIF, Raman) sowie erstmalig Methoden der Roentgenstreuung (EDXD, SAXS, WAXS) und Roentgenfluoreszenz (RFA, XANES) ermoeglicht. Fuer alle genannten Methoden erwies sich die wandlose Probenhalterung als vorteilhaft. So sind die Untersuchungsergebnisse vergleichbar mit denen herkoemmlicher Probenhalter und uebertreffen diese teilweise hinsichtlich der Datenqualitaet. Einen besonderen Erfolg stellt die Integration des akustischen Levitators in die experimentellen Aufbauten der Messplaetze am Synchrotron dar. Die Anwendung der Ultraschallfalle am BESSY konnte im Rahmen dieser Arbeit etabliert werden und bildet derzeit die Grundlage intensiver interdisziplinaerer Forschung. Ausserdem wurde das Potential der Falle zur Aufkonzentration erkannt und zum Studium verdunstungskontrollierter Prozesse angewendet. Die

  4. Analytical developments in reprocessing at the CEA

    International Nuclear Information System (INIS)

    Buffereau, M.

    1989-01-01

    Analytical developments in reprocessing, which are based on extensive basic research, are aimed at fulfilling current requirements of R and D laboratories, pilot plants and industrial plants. They are also intended to propose and provide new opportunities. On-line measurements are a long term goal. One must be confident of their outcome. New equipment and procedures must be tested and their specifications determined, first at the laboratory level, and then in a pilot plant. In this respect we are considering equipment which will be in operation in the ATALANTE laboratories. And APM is also both a necessary and useful resource. However, many measurements must still be done and will continue to have to be done in analytical laboratories. Along with the improvement of accuracy the main developments aim at reducing manpower requirements and effluents and waste releases

  5. Neutron activation analysis as analytical tool of environmental issue

    International Nuclear Information System (INIS)

    Otoshi, Tsunehiko

    2004-01-01

    Neutron activation analysis (NAA) ia applicable to the sample of wide range of research fields, such as material science, biology, geochemistry and so on. However, respecting the advantages of NAA, a sample with small amounts or a precious sample is the most suitable samples for NAA, because NAA is capable of trace analysis and non-destructive determination. In this paper, among these fields, NAA of atmospheric particulate matter (PM) sample is discussed emphasizing on the use of obtained data as an analytical tool of environmental issue. Concentration of PM in air is usually very low, and it is not easy to get vast amount of sample even using a high volume air sampling devise. Therefore, high sensitive NAA is suitable to determine elements in PM samples. Main components of PM is crust oriented silicate, and so on in rural/remote area, and carbonic materials and heavy metals are concentrated in PM in urban area, because of automobile exhaust and other anthropogenic emission source. Elemental pattern of PM reflects a condition of air around the monitoring site. Trends of air pollution can be traced by periodical monitoring of PM by NAA method. Elemental concentrations in air change by season. For example, crustal elements increase in dry season, and sea salts components increase their concentration when wind direction from sea is dominant. Elements that emitted from anthropogenic sources are mainly contained in fine portion of PM, and increase their concentration during winter season, when emission from heating system is high and air is stable. For further analysis and understanding of environmental issues, indicator elements for various emission sources, and elemental concentration ratios of some environmental samples and source portion assignment techniques are useful. (author)

  6. Developing new chemical tools for solvent extraction

    International Nuclear Information System (INIS)

    Moyer, B.A.; Baes, C.F.; Burns, J.H.; Case, G.N.; Sachleben, R.A.; Bryan, S.A.; Lumetta, G.J.; McDowell, W.J.; Sachleben, R.A.

    1993-01-01

    Prospects for innovation and for greater technological impact in the field of solvent extraction (SX) seem as bright as ever, despite the maturation of SX as an economically significant separation method and as an important technique in the laboratory. New industrial, environmental, and analytical problems provide compelling motivation for diversifying the application of SX, developing new solvent systems, and seeking improved properties. Toward this end, basic research must be dedicated to enhancing the tools of SX: physical tools for probing the basis of extraction and molecular tools for developing new SX chemistries. In this paper, the authors describe their progress in developing and applying the general tools of equilibrium analysis and of ion recognition in SX. Nearly half a century after the field of SX began in earnest, coordination chemistry continues to provide the impetus for important advancements in understanding SX systems and in controlling SX chemistry. In particular, the physical tools of equilibrium analysis, X-ray crystallography, and spectroscopy are elucidating the molecular basis of SX in unprecedented detail. Moreover, the principles of ion recognition are providing the molecular tools with which to achieve new selectivities and new applications

  7. ATTIRE (analytical tools for thermal infrared engineering): A sensor simulation and modeling package

    Science.gov (United States)

    Jaggi, S.

    1993-01-01

    The Advanced Sensor Development Laboratory (ASDL) at the Stennis Space Center develops, maintains and calibrates remote sensing instruments for the National Aeronautics & Space Administration (NASA). To perform system design trade-offs, analysis, and establish system parameters, ASDL has developed a software package for analytical simulation of sensor systems. This package called 'Analytical Tools for Thermal InfraRed Engineering' - ATTIRE, simulates the various components of a sensor system. The software allows each subsystem of the sensor to be analyzed independently for its performance. These performance parameters are then integrated to obtain system level information such as Signal-to-Noise Ratio (SNR), Noise Equivalent Radiance (NER), Noise Equivalent Temperature Difference (NETD) etc. This paper describes the uses of the package and the physics that were used to derive the performance parameters.

  8. Microplasmas for chemical analysis: analytical tools or research toys?

    International Nuclear Information System (INIS)

    Karanassios, Vassili

    2004-01-01

    An overview of the activities of the research groups that have been involved in fabrication, development and characterization of microplasmas for chemical analysis over the last few years is presented. Microplasmas covered include: miniature inductively coupled plasmas (ICPs); capacitively coupled plasmas (CCPs); microwave-induced plasmas (MIPs); a dielectric barrier discharge (DBD); microhollow cathode discharge (MCHD) or microstructure electrode (MSE) discharges, other microglow discharges (such as those formed between 'liquid' electrodes); microplasmas formed in micrometer-diameter capillary tubes for gas chromatography (GC) or high-performance liquid chromatography (HPLC) applications, and a stabilized capacitive plasma (SCP) for GC applications. Sample introduction into microplasmas, in particular, into a microplasma device (MPD), battery operation of a MPD and of a mini- in-torch vaporization (ITV) microsample introduction system for MPDs, and questions of microplasma portability for use on site (e.g., in the field) are also briefly addressed using examples of current research. To emphasize the significance of sample introduction into microplasmas, some previously unpublished results from the author's laboratory have also been included. And an overall assessment of the state-of-the-art of analytical microplasma research is provided

  9. Factors Influencing Attitudes Towards the Use of CRM’s Analytical Tools in Organizations

    Directory of Open Access Journals (Sweden)

    Šebjan Urban

    2016-02-01

    Full Text Available Background and Purpose: Information solutions for analytical customer relationship management CRM (aCRM IS that include the use of analytical tools are becoming increasingly important, due organizations’ need for knowledge of their customers and the ability to manage big data. The objective of the research is, therefore, to determine how the organizations’ orientations (process, innovation, and technology as critical organizational factors affect the attitude towards the use of the analytical tools of aCRM IS.

  10. Cluster Analysis as an Analytical Tool of Population Policy

    Directory of Open Access Journals (Sweden)

    Oksana Mikhaylovna Shubat

    2017-12-01

    Full Text Available The predicted negative trends in Russian demography (falling birth rates, population decline actualize the need to strengthen measures of family and population policy. Our research purpose is to identify groups of Russian regions with similar characteristics in the family sphere using cluster analysis. The findings should make an important contribution to the field of family policy. We used hierarchical cluster analysis based on the Ward method and the Euclidean distance for segmentation of Russian regions. Clustering is based on four variables, which allowed assessing the family institution in the region. The authors used the data of Federal State Statistics Service from 2010 to 2015. Clustering and profiling of each segment has allowed forming a model of Russian regions depending on the features of the family institution in these regions. The authors revealed four clusters grouping regions with similar problems in the family sphere. This segmentation makes it possible to develop the most relevant family policy measures in each group of regions. Thus, the analysis has shown a high degree of differentiation of the family institution in the regions. This suggests that a unified approach to population problems’ solving is far from being effective. To achieve greater results in the implementation of family policy, a differentiated approach is needed. Methods of multidimensional data classification can be successfully applied as a relevant analytical toolkit. Further research could develop the adaptation of multidimensional classification methods to the analysis of the population problems in Russian regions. In particular, the algorithms of nonparametric cluster analysis may be of relevance in future studies.

  11. Nuclear analytical chemistry: recent developments and applications

    International Nuclear Information System (INIS)

    Acharya, R.

    2013-01-01

    Recent R and D studies on Nuclear Analytical Chemistry utilizing techniques like Neutron Activation Analysis (NAA), Prompt Gamma-ray NAA (PGNAA), Particle Induced Gamma Ray and X-Ray Emission (PICE/PIXE) for compositional analysis of materials have been summarized. The work includes developments and applications of (i) single comparator NAA, called as k 0 -NAA, (ii) k 0 -based internal monostandard NAA (IM-NAA), (iii) k 0 -based prompt gamma ray NAA (PGNAA) and (iv) instrumental NAA using thermal and epithermal neutrons and (v) PIGE and PIXE methods using proton beam for low Z and medium Z elements, respectively. (author)

  12. A Business Analytics Software Tool for Monitoring and Predicting Radiology Throughput Performance.

    Science.gov (United States)

    Jones, Stephen; Cournane, Seán; Sheehy, Niall; Hederman, Lucy

    2016-12-01

    Business analytics (BA) is increasingly being utilised by radiology departments to analyse and present data. It encompasses statistical analysis, forecasting and predictive modelling and is used as an umbrella term for decision support and business intelligence systems. The primary aim of this study was to determine whether utilising BA technologies could contribute towards improved decision support and resource management within radiology departments. A set of information technology requirements were identified with key stakeholders, and a prototype BA software tool was designed, developed and implemented. A qualitative evaluation of the tool was carried out through a series of semi-structured interviews with key stakeholders. Feedback was collated, and emergent themes were identified. The results indicated that BA software applications can provide visibility of radiology performance data across all time horizons. The study demonstrated that the tool could potentially assist with improving operational efficiencies and management of radiology resources.

  13. Advances in analytical tools for high throughput strain engineering

    DEFF Research Database (Denmark)

    Marcellin, Esteban; Nielsen, Lars Keld

    2018-01-01

    The emergence of inexpensive, base-perfect genome editing is revolutionising biology. Modern industrial biotechnology exploits the advances in genome editing in combination with automation, analytics and data integration to build high-throughput automated strain engineering pipelines also known...... as biofoundries. Biofoundries replace the slow and inconsistent artisanal processes used to build microbial cell factories with an automated design–build–test cycle, considerably reducing the time needed to deliver commercially viable strains. Testing and hence learning remains relatively shallow, but recent...... advances in analytical chemistry promise to increase the depth of characterization possible. Analytics combined with models of cellular physiology in automated systems biology pipelines should enable deeper learning and hence a steeper pitch of the learning cycle. This review explores the progress...

  14. The MSCA Program: Developing Analytic Unicorns

    Science.gov (United States)

    Houghton, David M.; Schertzer, Clint; Beck, Scott

    2018-01-01

    Marketing analytics students who can communicate effectively with decision makers are in high demand. These "analytic unicorns" are hard to find. The Master of Science in Customer Analytics (MSCA) degree program at Xavier University seeks to fill that need. In this paper, we discuss the process of creating the MSCA program. We outline…

  15. ICT tools for curriculum development

    NARCIS (Netherlands)

    McKenney, Susan; Nieveen, N.M.; van den Akker, J.J.H.; Kuiper, W.J.A.M.; Hameyer, U.

    2003-01-01

    Along with others in this book, this chapter examines a recent trend in curriculum development, namely, employing the computer to support this complex process. Not to be confused with the vast majority of ICT tools for education, which support the teachers and learners more directly, this discussion

  16. Employability Skills Assessment Tool Development

    Science.gov (United States)

    Rasul, Mohamad Sattar; Rauf, Rose Amnah Abd; Mansor, Azlin Norhaini; Puvanasvaran, A. P.

    2012-01-01

    Research nationally and internationally found that technical graduates are lacking in employability skills. As employability skills are crucial in outcome-based education, the main goal of this research is to develop an Employability Skill Assessment Tool to help students and lecturers produce competent graduates in employability skills needed by…

  17. Nuclear imaging drug development tools

    International Nuclear Information System (INIS)

    Buchanan, L.; Jurek, P.; Redshaw, R.

    2007-01-01

    This article describes the development of nuclear imaging as an enabling technology in the pharmaceutical industry. Molecular imaging is maturing into an important tool with expanding applications from validating that a drug reaches the intended target through to market launch of a new drug. Molecular imaging includes anatomical imaging of organs or tissues, computerized tomography (CT), magnetic resonance imaging (MRI) and ultrasound.

  18. Kalisphera: an analytical tool to reproduce the partial volume effect of spheres imaged in 3D

    International Nuclear Information System (INIS)

    Tengattini, Alessandro; Andò, Edward

    2015-01-01

    In experimental mechanics, where 3D imaging is having a profound effect, spheres are commonly adopted for their simplicity and for the ease of their modeling. In this contribution we develop an analytical tool, ‘kalisphera’, to produce 3D raster images of spheres including their partial volume effect. This allows us to evaluate the metrological performance of existing image-based measurement techniques (knowing a priori the ground truth). An advanced application of ‘kalisphera’ is developed here to identify and accurately characterize spheres in real 3D x-ray tomography images with the objective of improving trinarization and contact detection. The effect of the common experimental imperfections is assessed and the overall performance of the tool tested on real images. (paper)

  19. Analytical Design Package (ADP2): A computer aided engineering tool for aircraft transparency design

    Science.gov (United States)

    Wuerer, J. E.; Gran, M.; Held, T. W.

    1994-01-01

    The Analytical Design Package (ADP2) is being developed as a part of the Air Force Frameless Transparency Program (FTP). ADP2 is an integrated design tool consisting of existing analysis codes and Computer Aided Engineering (CAE) software. The objective of the ADP2 is to develop and confirm an integrated design methodology for frameless transparencies, related aircraft interfaces, and their corresponding tooling. The application of this methodology will generate high confidence for achieving a qualified part prior to mold fabrication. ADP2 is a customized integration of analysis codes, CAE software, and material databases. The primary CAE integration tool for the ADP2 is P3/PATRAN, a commercial-off-the-shelf (COTS) software tool. The open architecture of P3/PATRAN allows customized installations with different applications modules for specific site requirements. Integration of material databases allows the engineer to select a material, and those material properties are automatically called into the relevant analysis code. The ADP2 materials database will be composed of four independent schemas: CAE Design, Processing, Testing, and Logistics Support. The design of ADP2 places major emphasis on the seamless integration of CAE and analysis modules with a single intuitive graphical interface. This tool is being designed to serve and be used by an entire project team, i.e., analysts, designers, materials experts, and managers. The final version of the software will be delivered to the Air Force in Jan. 1994. The Analytical Design Package (ADP2) will then be ready for transfer to industry. The package will be capable of a wide range of design and manufacturing applications.

  20. Can We Practically Bring Physics-based Modeling Into Operational Analytics Tools?

    Energy Technology Data Exchange (ETDEWEB)

    Granderson, Jessica [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bonvini, Marco [Whisker Labs, Oakland, CA (United States); Piette, Mary Ann [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Page, Janie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lin, Guanjing [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hu, R. Lilly [Univ. of California, Berkeley, CA (United States)

    2017-08-11

    We present that analytics software is increasingly used to improve and maintain operational efficiency in commercial buildings. Energy managers, owners, and operators are using a diversity of commercial offerings often referred to as Energy Information Systems, Fault Detection and Diagnostic (FDD) systems, or more broadly Energy Management and Information Systems, to cost-effectively enable savings on the order of ten to twenty percent. Most of these systems use data from meters and sensors, with rule-based and/or data-driven models to characterize system and building behavior. In contrast, physics-based modeling uses first-principles and engineering models (e.g., efficiency curves) to characterize system and building behavior. Historically, these physics-based approaches have been used in the design phase of the building life cycle or in retrofit analyses. Researchers have begun exploring the benefits of integrating physics-based models with operational data analytics tools, bridging the gap between design and operations. In this paper, we detail the development and operator use of a software tool that uses hybrid data-driven and physics-based approaches to cooling plant FDD and optimization. Specifically, we describe the system architecture, models, and FDD and optimization algorithms; advantages and disadvantages with respect to purely data-driven approaches; and practical implications for scaling and replicating these techniques. Finally, we conclude with an evaluation of the future potential for such tools and future research opportunities.

  1. Mapping healthcare systems: a policy relevant analytic tool.

    Science.gov (United States)

    Sekhri Feachem, Neelam; Afshar, Ariana; Pruett, Cristina; Avanceña, Anton L V

    2017-07-01

    In the past decade, an international consensus on the value of well-functioning systems has driven considerable health systems research. This research falls into two broad categories. The first provides conceptual frameworks that take complex healthcare systems and create simplified constructs of interactions and functions. The second focuses on granular inputs and outputs. This paper presents a novel translational mapping tool - the University of California, San Francisco mapping tool (the Tool) - which bridges the gap between these two areas of research, creating a platform for multi-country comparative analysis. Using the Murray-Frenk framework, we create a macro-level representation of a country's structure, focusing on how it finances and delivers healthcare. The map visually depicts the fundamental policy questions in healthcare system design: funding sources and amount spent through each source, purchasers, populations covered, provider categories; and the relationship between these entities. We use the Tool to provide a macro-level comparative analysis of the structure of India's and Thailand's healthcare systems. As part of the systems strengthening arsenal, the Tool can stimulate debate about the merits and consequences of different healthcare systems structural designs, using a common framework that fosters multi-country comparative analyses. © The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

  2. Information and Analytic Maintenance of Nanoindustry Development

    Directory of Open Access Journals (Sweden)

    Glushchenko Aleksandra Vasilyevna

    2015-05-01

    Full Text Available The successful course of nanotechnological development in many respects depends on the volume and quality of information provided to external and internal users. The objective of the present research is to reveal the information requirements of various groups of users for effective management of nanotech industry and to define ways of their most effective satisfaction. The authors also aim at developing the system of the indicators characterizing the current state and the dynamic parameters of nanotech industry development. On the basis of the conducted research the need of information system of nanotech industry development is proved. The information interrelations of subjects of nanotech industry for development of communicative function of the account which becomes dominating in comparison with control function are revealed. The information needs of users of financial and non-financial information are defined. The stages of its introduction, since determination of character, volume, the list and degree of efficiency of information before creation of system of the administrative reporting, the analysis and control are in detail registered. The information and analytical system is focused on the general assessment of efficiency and the major economic indicators, the general tendencies of development of nanotech industry, possible reserves of increasing the efficiency of their functioning. The authors develop pthe system of the indicators characterizing the advancement of nanotech industry and allowing to estimate innovative activity in the sphere of nanotech industry, to calculate intensity of nano-innovations costs, to define the productivity and efficiency of nanotech industry in branch, the region, national economy in general.

  3. Development of Simulator Configuration Tool

    International Nuclear Information System (INIS)

    Nedrelid, Olav; Pettersen, Geir

    1996-01-01

    The main objective of the development of a Simulator Configuration Tool (SCT) is to achieve faster and more efficient production of dynamic simulators. Through application of versatile graphical interfaces, the simulator builder should be able to configure different types of simulators including full-scope process simulators. The SCT should be able to serve different simulator environments. The configuration tool communicates with simulator execution environments through a TCP/IP-based interface, Communication with a Model Server System developed at Institutt for energiteknikk has been established and used as test case. The system consists of OSF/Motif dialogues for operations requiring textual input, list selections etc., and uses the Picasso-3 User Interface Management System to handle presentation of static and dynamic graphical information. (author)

  4. Application of quantum dots as analytical tools in automated chemical analysis: A review

    International Nuclear Information System (INIS)

    Frigerio, Christian; Ribeiro, David S.M.; Rodrigues, S. Sofia M.; Abreu, Vera L.R.G.; Barbosa, João A.C.; Prior, João A.V.; Marques, Karine L.; Santos, João L.M.

    2012-01-01

    Highlights: ► Review on quantum dots application in automated chemical analysis. ► Automation by using flow-based techniques. ► Quantum dots in liquid chromatography and capillary electrophoresis. ► Detection by fluorescence and chemiluminescence. ► Electrochemiluminescence and radical generation. - Abstract: Colloidal semiconductor nanocrystals or quantum dots (QDs) are one of the most relevant developments in the fast-growing world of nanotechnology. Initially proposed as luminescent biological labels, they are finding new important fields of application in analytical chemistry, where their photoluminescent properties have been exploited in environmental monitoring, pharmaceutical and clinical analysis and food quality control. Despite the enormous variety of applications that have been developed, the automation of QDs-based analytical methodologies by resorting to automation tools such as continuous flow analysis and related techniques, which would allow to take advantage of particular features of the nanocrystals such as the versatile surface chemistry and ligand binding ability, the aptitude to generate reactive species, the possibility of encapsulation in different materials while retaining native luminescence providing the means for the implementation of renewable chemosensors or even the utilisation of more drastic and even stability impairing reaction conditions, is hitherto very limited. In this review, we provide insights into the analytical potential of quantum dots focusing on prospects of their utilisation in automated flow-based and flow-related approaches and the future outlook of QDs applications in chemical analysis.

  5. An Analytical Study of Tools and Techniques for Movie Marketing

    Directory of Open Access Journals (Sweden)

    Garima Maik

    2014-08-01

    Full Text Available Abstract. Bollywood or Hindi movie industry is one of the fastest growing sector in the media and entertainment space creating numerous business and employment opportunities. Movies in India are a major source of entertainment for all sects of society. They not only face competition from other movie industries and movies but from other source of entertainment such as adventure sports, amusement parks, theatre and drama, pubs and discothèques. A lot of man power, man hours, creative brains, and money are put in to build a quality feature film. Bollywood is the industry which continuously works towards providing the 7 billion population with something new always. So it is important for the movie and production team to stand out, to grab the due attention of the maximum audience. Movie makers employ various tools and techniques today to market their movies. They leave no stone unturned. They roll out teasers, First look, Theatrical trailer release, Music launch, City tours, Producer’s and director’s interview, Movie premier, Movie release, post release follow up and etc. to pull the viewers to the Cineplex. The audience today which comprises mainly of youth requires photos, videos, meet ups, gossip, debate, collaboration and content creation. These requirements of today’s generation are most fulfilled through digital platforms. However, the traditional media like newspapers, radio, and television are not old school. They reach out to mass audience and play an upper role in effective marketing. This study aims at analysing these tools for their effectiveness. The objectives are fulfilled through a consumer survey. This study will bring out the effectiveness and relational importance of various tools which are employed by movie marketers to generate maximum returns on the investments by using various data reduction techniques like factor analysis and statistical techniques like chi-square test with data visualization using pie charts

  6. Median of patient results as a tool for assessment of analytical stability

    DEFF Research Database (Denmark)

    Jørgensen, Lars Mønster; Hansen, Steen Ingemann; Petersen, Per Hyltoft

    2015-01-01

    BACKGROUND: In spite of the well-established external quality assessment and proficiency testing surveys of analytical quality performance in laboratory medicine, a simple tool to monitor the long-term analytical stability as a supplement to the internal control procedures is often needed. METHOD......: Patient data from daily internal control schemes was used for monthly appraisal of the analytical stability. This was accomplished by using the monthly medians of patient results to disclose deviations from analytical stability, and by comparing divergences with the quality specifications for allowable...... analytical bias based on biological variation. RESULTS: Seventy five percent of the twenty analytes achieved on two COBASs INTEGRA 800 instruments performed in accordance with the optimum and with the desirable specifications for bias. DISCUSSION: Patient results applied in analytical quality performance...

  7. Improving web site performance using commercially available analytical tools.

    Science.gov (United States)

    Ogle, James A

    2010-10-01

    It is easy to accurately measure web site usage and to quantify key parameters such as page views, site visits, and more complex variables using commercially available tools that analyze web site log files and search engine use. This information can be used strategically to guide the design or redesign of a web site (templates, look-and-feel, and navigation infrastructure) to improve overall usability. The data can also be used tactically to assess the popularity and use of new pages and modules that are added and to rectify problems that surface. This paper describes software tools used to: (1) inventory search terms that lead to available content; (2) propose synonyms for commonly used search terms; (3) evaluate the effectiveness of calls to action; (4) conduct path analyses to targeted content. The American Academy of Orthopaedic Surgeons (AAOS) uses SurfRay's Behavior Tracking software (Santa Clara CA, USA, and Copenhagen, Denmark) to capture and archive the search terms that have been entered into the site's Google Mini search engine. The AAOS also uses Unica's NetInsight program to analyze its web site log files. These tools provide the AAOS with information that quantifies how well its web sites are operating and insights for making improvements to them. Although it is easy to quantify many aspects of an association's web presence, it also takes human involvement to analyze the results and then recommend changes. Without a dedicated resource to do this, the work often is accomplished only sporadically and on an ad hoc basis.

  8. Analytics to Literacies: The Development of a Learning Analytics Framework for Multiliteracies Assessment

    Directory of Open Access Journals (Sweden)

    Shane Dawson

    2014-09-01

    Full Text Available The rapid advances in information and communication technologies, coupled with increased access to information and the formation of global communities, have resulted in interest among researchers and academics to revise educational practice to move beyond traditional ‘literacy’ skills towards an enhanced set of “multiliteracies” or “new media literacies”. Measuring the literacy of a population, in the light of its linkage to individual and community wealth and wellbeing, is essential to determining the impact of compulsory education. The opportunity now is to develop tools to assess individual and societal attainment of these new literacies. Drawing on the work of Jenkins and colleagues (2006 and notions of a participatory culture, this paper proposes a conceptual framework for how learning analytics can assist in measuring individual achievement of multiliteracies and how this evaluative process can be scaled to provide an institutional perspective of the educational progress in fostering these fundamental skills.

  9. Practical applications of surface analytic tools in tribology

    Science.gov (United States)

    Ferrante, J.

    1980-01-01

    Many of the currently, widely used tools available for surface analysis are described. Those which have the highest applicability for giving elemental and/or compound analysis for problems of interest in tribology and are truly surface sensitive (that is, less than 10 atomic layers) are presented. The latter group is evaluated in detail in terms of strengths and weaknesses. Emphasis is placed on post facto analysis of experiments performed under 'real' conditions (e.g., in air with lubricants). It is further indicated that such equipment could be used for screening and quality control.

  10. Ethnography in design: Tool-kit or analytic science?

    DEFF Research Database (Denmark)

    Bossen, Claus

    2002-01-01

    The role of ethograpyh in system development is discussed through the selective application of an ethnographic easy-to-use toolkit, Contextual design, by a computer firm in the initial stages of the development of a health care system....

  11. Median of patient results as a tool for assessment of analytical stability.

    Science.gov (United States)

    Jørgensen, Lars Mønster; Hansen, Steen Ingemann; Petersen, Per Hyltoft; Sölétormos, György

    2015-06-15

    In spite of the well-established external quality assessment and proficiency testing surveys of analytical quality performance in laboratory medicine, a simple tool to monitor the long-term analytical stability as a supplement to the internal control procedures is often needed. Patient data from daily internal control schemes was used for monthly appraisal of the analytical stability. This was accomplished by using the monthly medians of patient results to disclose deviations from analytical stability, and by comparing divergences with the quality specifications for allowable analytical bias based on biological variation. Seventy five percent of the twenty analytes achieved on two COBASs INTEGRA 800 instruments performed in accordance with the optimum and with the desirable specifications for bias. Patient results applied in analytical quality performance control procedures are the most reliable sources of material as they represent the genuine substance of the measurements and therefore circumvent the problems associated with non-commutable materials in external assessment. Patient medians in the monthly monitoring of analytical stability in laboratory medicine are an inexpensive, simple and reliable tool to monitor the steadiness of the analytical practice. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Laser: a Tool for Optimization and Enhancement of Analytical Methods

    Energy Technology Data Exchange (ETDEWEB)

    Preisler, Jan [Iowa State Univ., Ames, IA (United States)

    1997-01-01

    In this work, we use lasers to enhance possibilities of laser desorption methods and to optimize coating procedure for capillary electrophoresis (CE). We use several different instrumental arrangements to characterize matrix-assisted laser desorption (MALD) at atmospheric pressure and in vacuum. In imaging mode, 488-nm argon-ion laser beam is deflected by two acousto-optic deflectors to scan plumes desorbed at atmospheric pressure via absorption. All absorbing species, including neutral molecules, are monitored. Interesting features, e.g. differences between the initial plume and subsequent plumes desorbed from the same spot, or the formation of two plumes from one laser shot are observed. Total plume absorbance can be correlated with the acoustic signal generated by the desorption event. A model equation for the plume velocity as a function of time is proposed. Alternatively, the use of a static laser beam for observation enables reliable determination of plume velocities even when they are very high. Static scattering detection reveals negative influence of particle spallation on MS signal. Ion formation during MALD was monitored using 193-nm light to photodissociate a portion of insulin ion plume. These results define the optimal conditions for desorbing analytes from matrices, as opposed to achieving a compromise between efficient desorption and efficient ionization as is practiced in mass spectrometry. In CE experiment, we examined changes in a poly(ethylene oxide) (PEO) coating by continuously monitoring the electroosmotic flow (EOF) in a fused-silica capillary during electrophoresis. An imaging CCD camera was used to follow the motion of a fluorescent neutral marker zone along the length of the capillary excited by 488-nm Ar-ion laser. The PEO coating was shown to reduce the velocity of EOF by more than an order of magnitude compared to a bare capillary at pH 7.0. The coating protocol was important, especially at an intermediate pH of 7.7. The increase of p

  13. Positron spectroscopy as an analytical tool in material sciences

    International Nuclear Information System (INIS)

    Pujari, P.K.

    2010-01-01

    Full text: Positron annihilation spectroscopy has emerged as a powerful tool in material sciences due to its ability to provide information about the electron momentum distribution and electron density in a given medium. These features help in identifying altered state of electronic rearrangements as one encounters in phase transitions. In addition, positrons prefer regions of lower electron density such as open volume defects i.e. vacancies or vacancy clusters in metals, alloys and semiconductors or free-volumes in molecular solids. Its sensitivity to defects is extremely high e.g. it can detect as small a defect as monovacancy to concentration as low as parts per million(ppm). Innovative nuclear instrumentation has helped in getting chemical specificity at the annihilation site. For example, precipitates, embedded, nanoparticles or element decorated vacancies can now be easily identified. This presentation is structured to introduce the technique and provide a global perspective on area of applications. Specific examples on defect characterization, nanostructure-property correlations in polymers, advantages of elemental specificity by indexing the core electron momentum will be given. In addition, slow positron beam based studies on nanostructured materials as well as particle accelerator based positron spectroscopy for volumetric assay of defects in large engineering samples will be presented

  14. Analytical Modeling Tool for Design of Hydrocarbon Sensitive Optical Fibers

    Directory of Open Access Journals (Sweden)

    Khalil Al Handawi

    2017-09-01

    Full Text Available Pipelines are the main transportation means for oil and gas products across large distances. Due to the severe conditions they operate in, they are regularly inspected using conventional Pipeline Inspection Gages (PIGs for corrosion damage. The motivation for researching a real-time distributed monitoring solution arose to mitigate costs and provide a proactive indication of potential failures. Fiber optic sensors with polymer claddings provide a means of detecting contact with hydrocarbons. By coating the fibers with a layer of metal similar in composition to that of the parent pipeline, corrosion of this coating may be detected when the polymer cladding underneath is exposed to the surrounding hydrocarbons contained within the pipeline. A Refractive Index (RI change occurs in the polymer cladding causing a loss in intensity of a traveling light pulse due to a reduction in the fiber’s modal capacity. Intensity losses may be detected using Optical Time Domain Reflectometry (OTDR while pinpointing the spatial location of the contact via time delay calculations of the back-scattered pulses. This work presents a theoretical model for the above sensing solution to provide a design tool for the fiber optic cable in the context of hydrocarbon sensing following corrosion of an external metal coating. Results are verified against the experimental data published in the literature.

  15. Analytical Modeling Tool for Design of Hydrocarbon Sensitive Optical Fibers.

    Science.gov (United States)

    Al Handawi, Khalil; Vahdati, Nader; Shiryayev, Oleg; Lawand, Lydia

    2017-09-28

    Pipelines are the main transportation means for oil and gas products across large distances. Due to the severe conditions they operate in, they are regularly inspected using conventional Pipeline Inspection Gages (PIGs) for corrosion damage. The motivation for researching a real-time distributed monitoring solution arose to mitigate costs and provide a proactive indication of potential failures. Fiber optic sensors with polymer claddings provide a means of detecting contact with hydrocarbons. By coating the fibers with a layer of metal similar in composition to that of the parent pipeline, corrosion of this coating may be detected when the polymer cladding underneath is exposed to the surrounding hydrocarbons contained within the pipeline. A Refractive Index (RI) change occurs in the polymer cladding causing a loss in intensity of a traveling light pulse due to a reduction in the fiber's modal capacity. Intensity losses may be detected using Optical Time Domain Reflectometry (OTDR) while pinpointing the spatial location of the contact via time delay calculations of the back-scattered pulses. This work presents a theoretical model for the above sensing solution to provide a design tool for the fiber optic cable in the context of hydrocarbon sensing following corrosion of an external metal coating. Results are verified against the experimental data published in the literature.

  16. Process simulation of heavy water plants - a powerful analytical tool

    International Nuclear Information System (INIS)

    Miller, A.I.

    1978-10-01

    The commercially conscious designs of Canadian GS (Girdler-Sulphide) have proved sensitive to process conditions. That, combined with the large scale of our units, has meant that computer simulation of their behaviour has been a natural and profitable development. Atomic Energy of Canada Limited has developed a family of steady state simulations to describe all of the Canadian plants. Modelling of plant conditions has demonstrated that the simulation description is very precise and it has become an integral part of the industry's assessments of both plant operation and decisions on capital expenditures. The simulation technique has also found extensive use in detailed designing of both the rehabilitated Glace Bay and the new La Prade plants. It has opened new insights into plant design and uncovered a radical and significant flowsheet change for future designs as well as many less dramatic but valuable lesser changes. (author)

  17. Capturing student mathematical engagement through differently enacted classroom practices: applying a modification of Watson's analytical tool

    Science.gov (United States)

    Patahuddin, Sitti Maesuri; Puteri, Indira; Lowrie, Tom; Logan, Tracy; Rika, Baiq

    2018-04-01

    This study examined student mathematical engagement through the intended and enacted lessons taught by two teachers in two different middle schools in Indonesia. The intended lesson was developed using the ELPSA learning design to promote mathematical engagement. Based on the premise that students will react to the mathematical tasks in the forms of words and actions, the analysis focused on identifying the types of mathematical engagement promoted through the intended lesson and performed by students during the lesson. Using modified Watson's analytical tool (2007), students' engagement was captured from what the participants' did or said mathematically. We found that teachers' enacted practices had an influence on student mathematical engagement. The teacher who demonstrated content in explicit ways tended to limit the richness of the engagement; whereas the teacher who presented activities in an open-ended manner fostered engagement.

  18. Analytical sensitivity analysis of geometric errors in a three axis machine tool

    International Nuclear Information System (INIS)

    Park, Sung Ryung; Yang, Seung Han

    2012-01-01

    In this paper, an analytical method is used to perform a sensitivity analysis of geometric errors in a three axis machine tool. First, an error synthesis model is constructed for evaluating the position volumetric error due to the geometric errors, and then an output variable is defined, such as the magnitude of the position volumetric error. Next, the global sensitivity analysis is executed using an analytical method. Finally, the sensitivity indices are calculated using the quantitative values of the geometric errors

  19. Status of immunoassay as an analytical tool in environmental investigations

    International Nuclear Information System (INIS)

    Van Emon, J.M.

    2000-01-01

    Immunoassay methods were initially applied in clinical situations where their sensitivity and selectivity were utilized for diagnostic purposes. In the 1970s, pesticide chemists realized the potential benefits of immunoassay methods for compounds difficult to analyze by gas chromatography. This transition of the technology has extended to the analysis of soil, water, food and other matrices of environmental and human exposure significance particularly for compounds difficult to analyze by chromatographic methods. The utility of radioimmunoassays and enzyme immunoassays for environmental investigations was recognized in the 1980s by the U.S. Environmental Protection Agency (U.S. EPA) with the initiation of an immunoassay development programme. The U.S. Department of Agriculture (USDA) and the U.S. Food and Drug Administration (PDA) have investigated immunoassays for the detection of residues in food both from an inspection and a contamination prevention perspective. Environmental immunoassays are providing rapid screening information as well as quantitative information to fulfill rigorous data quality objectives for monitoring programmes

  20. Horses for courses: analytical tools to explore planetary boundaries

    Science.gov (United States)

    van Vuuren, Detlef P.; Lucas, Paul L.; Häyhä, Tiina; Cornell, Sarah E.; Stafford-Smith, Mark

    2016-03-01

    There is a need for more integrated research on sustainable development and global environmental change. In this paper, we focus on the planetary boundaries framework to provide a systematic categorization of key research questions in relation to avoiding severe global environmental degradation. The four categories of key questions are those that relate to (1) the underlying processes and selection of key indicators for planetary boundaries, (2) understanding the impacts of environmental pressure and connections between different types of impacts, (3) better understanding of different response strategies to avoid further degradation, and (4) the available instruments to implement such strategies. Clearly, different categories of scientific disciplines and associated model types exist that can accommodate answering these questions. We identify the strength and weaknesses of different research areas in relation to the question categories, focusing specifically on different types of models. We discuss that more interdisciplinary research is need to increase our understanding by better linking human drivers and social and biophysical impacts. This requires better collaboration between relevant disciplines (associated with the model types), either by exchanging information or by fully linking or integrating them. As fully integrated models can become too complex, the appropriate type of model (the racehorse) should be applied for answering the target research question (the race course).

  1. ESR spectroscopy - an analytical tool for the glass industry

    International Nuclear Information System (INIS)

    Elvers, A.; Weissmann, R.

    2001-01-01

    In the past, wet chemical methods have been developed for the quantitative analysis of polyvalent elements in glasses. The major disadvantage of these chemical methods is that all structural information is lost during analysis. In addition, the analysis of species by wet chemical methods is unreliable due to possible redox reactions during the decomposition process. Therefore, the emphasis is on the physical methods which can directly detect species in bulk glasses. Especially optical and ESR spectroscopy are suitable methods due to their wide range of applications and sensitivity. Concerning quantitative measurements, no comparison between ESR results and chemical analysis of species has been published so far. This work discusses the possible application of ESR spectroscopy in the glass industry by focussing on routine interpretation, the correlation to chemical procedures and quantitative analysis. Results are presented and discussed for iron and chromium in packaging glasses. For example an excellent correlation was found between the Fe 3+ ESR signal and the chemically determined Fe 3+ concentration in glass. (orig.)

  2. Quantitative high throughput analytics to support polysaccharide production process development.

    Science.gov (United States)

    Noyes, Aaron; Godavarti, Ranga; Titchener-Hooker, Nigel; Coffman, Jonathan; Mukhopadhyay, Tarit

    2014-05-19

    The rapid development of purification processes for polysaccharide vaccines is constrained by a lack of analytical tools current technologies for the measurement of polysaccharide recovery and process-related impurity clearance are complex, time-consuming, and generally not amenable to high throughput process development (HTPD). HTPD is envisioned to be central to the improvement of existing polysaccharide manufacturing processes through the identification of critical process parameters that potentially impact the quality attributes of the vaccine and to the development of de novo processes for clinical candidates, across the spectrum of downstream processing. The availability of a fast and automated analytics platform will expand the scope, robustness, and evolution of Design of Experiment (DOE) studies. This paper details recent advances in improving the speed, throughput, and success of in-process analytics at the micro-scale. Two methods, based on modifications of existing procedures, are described for the rapid measurement of polysaccharide titre in microplates without the need for heating steps. A simplification of a commercial endotoxin assay is also described that features a single measurement at room temperature. These assays, along with existing assays for protein and nucleic acids are qualified for deployment in the high throughput screening of polysaccharide feedstreams. Assay accuracy, precision, robustness, interference, and ease of use are assessed and described. In combination, these assays are capable of measuring the product concentration and impurity profile of a microplate of 96 samples in less than one day. This body of work relies on the evaluation of a combination of commercially available and clinically relevant polysaccharides to ensure maximum versatility and reactivity of the final assay suite. Together, these advancements reduce overall process time by up to 30-fold and significantly reduce sample volume over current practices. The

  3. Ecotoxicity on a stick: A novel analytical tool for predicting the ecotoxicity of petroleum contaminated samples

    International Nuclear Information System (INIS)

    Parkerton, T.F.; Stone, M.A.

    1995-01-01

    Hydrocarbons generally elicit toxicity via a nonpolar narcotic mechanism. Recent research suggests that chemicals acting by this mode invoke ecotoxicity when the molar concentration in organisms lipid exceeds a critical threshold. Since ecotoxicity of nonpolar narcotic mixtures appears to be additive, the ecotoxicity of hydrocarbon mixtures thus depends upon: (1) the partitioning of individual hydrocarbons comprising the mixture from the environment to lipids and (2) the total molar sum of the constituent hydrocarbons in lipids. These insights have led previous investigators to advance the concept of biomimetic extraction as a novel tool for assessing potential narcosis-type or baseline ecotoxicity in aqueous samples. Drawing from this earlier work, the authors have developed a method to quantify Bioavailable Petroleum Hydrocarbons (BPHS) in hydrocarbon-contaminated aqueous and soil/sediment samples. A sample is equilibrated with a solid phase microextraction (SPME) fiber that serves as a surrogate for organism lipids. The total moles of hydrocarbons that partition to the SPME fiber is then quantified using a simple GC/FID procedure. Research conducted to support the development and initial validation of this method will be presented. Results suggest that BPH analyses provide a promising, cost-effective approach for predicting the ecotoxicity of environmental samples contaminated with hydrocarbon mixtures. Consequently, BPH analyses may provide a valuable analytical screening tool for ecotoxicity assessment in product and effluent testing, environmental monitoring and site remediation applications

  4. VisualUrText: A Text Analytics Tool for Unstructured Textual Data

    Science.gov (United States)

    Zainol, Zuraini; Jaymes, Mohd T. H.; Nohuddin, Puteri N. E.

    2018-05-01

    The growing amount of unstructured text over Internet is tremendous. Text repositories come from Web 2.0, business intelligence and social networking applications. It is also believed that 80-90% of future growth data is available in the form of unstructured text databases that may potentially contain interesting patterns and trends. Text Mining is well known technique for discovering interesting patterns and trends which are non-trivial knowledge from massive unstructured text data. Text Mining covers multidisciplinary fields involving information retrieval (IR), text analysis, natural language processing (NLP), data mining, machine learning statistics and computational linguistics. This paper discusses the development of text analytics tool that is proficient in extracting, processing, analyzing the unstructured text data and visualizing cleaned text data into multiple forms such as Document Term Matrix (DTM), Frequency Graph, Network Analysis Graph, Word Cloud and Dendogram. This tool, VisualUrText, is developed to assist students and researchers for extracting interesting patterns and trends in document analyses.

  5. Developing a Code of Practice for Learning Analytics

    Science.gov (United States)

    Sclater, Niall

    2016-01-01

    Ethical and legal objections to learning analytics are barriers to development of the field, thus potentially denying students the benefits of predictive analytics and adaptive learning. Jisc, a charitable organization that champions the use of digital technologies in UK education and research, has attempted to address this with the development of…

  6. System analysis: Developing tools for the future

    Energy Technology Data Exchange (ETDEWEB)

    De Jong, K.; clever, J.; Draper, J.V.; Davies, B.; Lonks, A.

    1996-02-01

    This report introduces and evaluates system analysis tools that were developed, or are under development, for the Robotics Technology Development Program (RTDP). Additionally, it discusses system analysis work completed using these tools aimed at completing a system analysis of the retrieval of waste from underground storage tanks on the Hanford Reservation near Richland, Washington. The tools developed and evaluated include a mixture of commercially available tools adapted to RTDP requirements, and some tools developed in house. The tools that are included in this report include: a Process Diagramming Tool, a Cost Modeling Tool, an Amortization Modeling Tool, a graphical simulation linked to the Cost Modeling Tool, a decision assistance tool, and a system thinking tool. Additionally, the importance of performance testing to the RTDP and the results of such testing executed is discussed. Further, the results of the Tank Waste Retrieval (TWR) System Diagram, the TWR Operations Cost Model, and the TWR Amortization Model are presented, and the implication of the results are discussed. Finally, the RTDP system analysis tools are assessed and some recommendations are made regarding continuing development of the tools and process.

  7. Recent developments in analytical detection methods for radiation processed foods

    International Nuclear Information System (INIS)

    Wu Jilan

    1993-01-01

    A short summary of the programmes of 'ADMIT' (FAO/IAEA) and the developments in analytical detection methods for radiation processed foods has been given. It is suggested that for promoting the commercialization of radiation processed foods and controlling its quality, one must pay more attention to the study of analytical detection methods of irradiated food

  8. Developing a Social Media Marketing tool

    OpenAIRE

    Valova, Olga

    2015-01-01

    The objective of the thesis is to develop a better, easier to use social media marketing tool that could be utilised in any business. By understanding and analysing how business uses social media as well as currently available social media marketing tools, design a tool with the maximum amount of features, but with a simple and intuitive User Interface. An agile software development life cycle was used throughout the creation of the tool. Qualitative analysis was used to analyse existing ...

  9. Measuring the bright side of being blue: a new tool for assessing analytical rumination in depression.

    Directory of Open Access Journals (Sweden)

    Skye P Barbic

    Full Text Available BACKGROUND: Diagnosis and management of depression occurs frequently in the primary care setting. Current diagnostic and management of treatment practices across clinical populations focus on eliminating signs and symptoms of depression. However, there is debate that some interventions may pathologize normal, adaptive responses to stressors. Analytical rumination (AR is an example of an adaptive response of depression that is characterized by enhanced cognitive function to help an individual focus on, analyze, and solve problems. To date, research on AR has been hampered by the lack of theoretically-derived and psychometrically sound instruments. This study developed and tested a clinically meaningful measure of AR. METHODS: Using expert panels and an extensive literature review, we developed a conceptual framework for AR and 22 candidate items. Items were field tested to 579 young adults; 140 of whom completed the items at a second time point. We used Rasch measurement methods to construct and test the item set; and traditional psychometric analyses to compare items to existing rating scales. RESULTS: Data were high quality (0.81; evidence for divergent validity. Evidence of misfit for 2 items suggested that a 20-item scale with 4-point response categories best captured the concept of AR, fitting the Rasch model (χ2 = 95.26; df = 76, p = 0.07, with high reliability (rp = 0.86, ordered response scale structure, and no item bias (gender, age, time. CONCLUSION: Our study provides evidence for a 20-item Analytical Rumination Questionnaire (ARQ that can be used to quantify AR in adults who experience symptoms of depression. The ARQ is psychometrically robust and a clinically useful tool for the assessment and improvement of depression in the primary care setting. Future work is needed to establish the validity of this measure in people with major depression.

  10. Stochastic airspace simulation tool development

    Science.gov (United States)

    2009-10-01

    Modeling and simulation is often used to study : the physical world when observation may not be : practical. The overall goal of a recent and ongoing : simulation tool project has been to provide a : documented, lifecycle-managed, multi-processor : c...

  11. Lowering the Barrier to Reproducible Research by Publishing Provenance from Common Analytical Tools

    Science.gov (United States)

    Jones, M. B.; Slaughter, P.; Walker, L.; Jones, C. S.; Missier, P.; Ludäscher, B.; Cao, Y.; McPhillips, T.; Schildhauer, M.

    2015-12-01

    Scientific provenance describes the authenticity, origin, and processing history of research products and promotes scientific transparency by detailing the steps in computational workflows that produce derived products. These products include papers, findings, input data, software products to perform computations, and derived data and visualizations. The geosciences community values this type of information, and, at least theoretically, strives to base conclusions on computationally replicable findings. In practice, capturing detailed provenance is laborious and thus has been a low priority; beyond a lab notebook describing methods and results, few researchers capture and preserve detailed records of scientific provenance. We have built tools for capturing and publishing provenance that integrate into analytical environments that are in widespread use by geoscientists (R and Matlab). These tools lower the barrier to provenance generation by automating capture of critical information as researchers prepare data for analysis, develop, test, and execute models, and create visualizations. The 'recordr' library in R and the `matlab-dataone` library in Matlab provide shared functions to capture provenance with minimal changes to normal working procedures. Researchers can capture both scripted and interactive sessions, tag and manage these executions as they iterate over analyses, and then prune and publish provenance metadata and derived products to the DataONE federation of archival repositories. Provenance traces conform to the ProvONE model extension of W3C PROV, enabling interoperability across tools and languages. The capture system supports fine-grained versioning of science products and provenance traces. By assigning global identifiers such as DOIs, reseachers can cite the computational processes used to reach findings. And, finally, DataONE has built a web portal to search, browse, and clearly display provenance relationships between input data, the software

  12. Studying Behaviors Among Neurosurgery Residents Using Web 2.0 Analytic Tools.

    Science.gov (United States)

    Davidson, Benjamin; Alotaibi, Naif M; Guha, Daipayan; Amaral, Sandi; Kulkarni, Abhaya V; Lozano, Andres M

    Web 2.0 technologies (e.g., blogs, social networks, and wikis) are increasingly being used by medical schools and postgraduate training programs as tools for information dissemination. These technologies offer the unique opportunity to track metrics of user engagement and interaction. Here, we employ Web 2.0 tools to assess academic behaviors among neurosurgery residents. We performed a retrospective review of all educational lectures, part of the core Neurosurgery Residency curriculum at the University of Toronto, posted on our teaching website (www.TheBrainSchool.net). Our website was developed using publicly available Web 2.0 platforms. Lecture usage was assessed by the number of clicks, and associations were explored with lecturer academic position, timing of examinations, and lecture/subspecialty topic. The overall number of clicks on 77 lectures was 1079. Most of these clicks were occurring during the in-training examination month (43%). Click numbers were significantly higher on lectures presented by faculty (mean = 18.6, standard deviation ± 4.1) compared to those delivered by residents (mean = 8.4, standard deviation ± 2.1) (p = 0.031). Lectures covering topics in functional neurosurgery received the most clicks (47%), followed by pediatric neurosurgery (22%). This study demonstrates the value of Web 2.0 analytic tools in examining resident study behavior. Residents tend to "cram" by downloading lectures in the same month of training examinations and display a preference for faculty-delivered lectures. Copyright © 2017 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  13. GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data.

    Science.gov (United States)

    Ben-Ari Fuchs, Shani; Lieder, Iris; Stelzer, Gil; Mazor, Yaron; Buzhor, Ella; Kaplan, Sergey; Bogoch, Yoel; Plaschkes, Inbar; Shitrit, Alina; Rappaport, Noa; Kohn, Asher; Edgar, Ron; Shenhav, Liraz; Safran, Marilyn; Lancet, Doron; Guan-Golan, Yaron; Warshawsky, David; Shtrichman, Ronit

    2016-03-01

    Postgenomics data are produced in large volumes by life sciences and clinical applications of novel omics diagnostics and therapeutics for precision medicine. To move from "data-to-knowledge-to-innovation," a crucial missing step in the current era is, however, our limited understanding of biological and clinical contexts associated with data. Prominent among the emerging remedies to this challenge are the gene set enrichment tools. This study reports on GeneAnalytics™ ( geneanalytics.genecards.org ), a comprehensive and easy-to-apply gene set analysis tool for rapid contextualization of expression patterns and functional signatures embedded in the postgenomics Big Data domains, such as Next Generation Sequencing (NGS), RNAseq, and microarray experiments. GeneAnalytics' differentiating features include in-depth evidence-based scoring algorithms, an intuitive user interface and proprietary unified data. GeneAnalytics employs the LifeMap Science's GeneCards suite, including the GeneCards®--the human gene database; the MalaCards-the human diseases database; and the PathCards--the biological pathways database. Expression-based analysis in GeneAnalytics relies on the LifeMap Discovery®--the embryonic development and stem cells database, which includes manually curated expression data for normal and diseased tissues, enabling advanced matching algorithm for gene-tissue association. This assists in evaluating differentiation protocols and discovering biomarkers for tissues and cells. Results are directly linked to gene, disease, or cell "cards" in the GeneCards suite. Future developments aim to enhance the GeneAnalytics algorithm as well as visualizations, employing varied graphical display items. Such attributes make GeneAnalytics a broadly applicable postgenomics data analyses and interpretation tool for translation of data to knowledge-based innovation in various Big Data fields such as precision medicine, ecogenomics, nutrigenomics, pharmacogenomics, vaccinomics

  14. Software Development Management: Empirical and Analytical Perspectives

    Science.gov (United States)

    Kang, Keumseok

    2011-01-01

    Managing software development is a very complex activity because it must deal with people, organizations, technologies, and business processes. My dissertation consists of three studies that examine software development management from various perspectives. The first study empirically investigates the impacts of prior experience with similar…

  15. Development of Open Textbooks Learning Analytics System

    Science.gov (United States)

    Prasad, Deepak; Totaram, Rajneel; Usagawa, Tsuyoshi

    2016-01-01

    Textbook costs have skyrocketed in recent years, putting them beyond the reach of many students, but there are options which can mitigate this problem. Open textbooks, an open educational resource, have proven capable of making textbooks affordable to students. There have been few educational development as promising as the development of open…

  16. Hasse diagram as a green analytical metrics tool: ranking of methods for benzo[a]pyrene determination in sediments.

    Science.gov (United States)

    Bigus, Paulina; Tsakovski, Stefan; Simeonov, Vasil; Namieśnik, Jacek; Tobiszewski, Marek

    2016-05-01

    This study presents an application of the Hasse diagram technique (HDT) as the assessment tool to select the most appropriate analytical procedures according to their greenness or the best analytical performance. The dataset consists of analytical procedures for benzo[a]pyrene determination in sediment samples, which were described by 11 variables concerning their greenness and analytical performance. Two analyses with the HDT were performed-the first one with metrological variables and the second one with "green" variables as input data. Both HDT analyses ranked different analytical procedures as the most valuable, suggesting that green analytical chemistry is not in accordance with metrology when benzo[a]pyrene in sediment samples is determined. The HDT can be used as a good decision support tool to choose the proper analytical procedure concerning green analytical chemistry principles and analytical performance merits.

  17. Program Development Tools and Infrastructures

    International Nuclear Information System (INIS)

    Schulz, M.

    2012-01-01

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  18. Program Development Tools and Infrastructures

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, M

    2012-03-12

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  19. New Tools to Prepare ACE Cross-section Files for MCNP Analytic Test Problems

    International Nuclear Information System (INIS)

    Brown, Forrest B.

    2016-01-01

    Monte Carlo calculations using one-group cross sections, multigroup cross sections, or simple continuous energy cross sections are often used to: (1) verify production codes against known analytical solutions, (2) verify new methods and algorithms that do not involve detailed collision physics, (3) compare Monte Carlo calculation methods with deterministic methods, and (4) teach fundamentals to students. In this work we describe 2 new tools for preparing the ACE cross-section files to be used by MCNP ® for these analytic test problems, simple a ce.pl and simple a ce m g.pl.

  20. Analytical framework of 'atoms for sustainable development'

    International Nuclear Information System (INIS)

    Lee, Tae Joon

    2010-01-01

    The term of 'Atoms for Sustainable Development' constantly pursues the increasing contribution of nuclear energy to the sustainable development which is providing an external kindling to the so-called nuclear renaissance. This paper explores a conceptual framework and a set of its elemental proxies to analyse the sustainable competitiveness of the nuclear energy system with a classification of the economic, environmental and social dimensions. (authors)

  1. Development of CAD implementing the algorithm of boundary elements’ numerical analytical method

    Directory of Open Access Journals (Sweden)

    Yulia V. Korniyenko

    2015-03-01

    Full Text Available Up to recent days the algorithms for numerical-analytical boundary elements method had been implemented with programs written in MATLAB environment language. Each program had a local character, i.e. used to solve a particular problem: calculation of beam, frame, arch, etc. Constructing matrices in these programs was carried out “manually” therefore being time-consuming. The research was purposed onto a reasoned choice of programming language for new CAD development, allows to implement algorithm of numerical analytical boundary elements method and to create visualization tools for initial objects and calculation results. Research conducted shows that among wide variety of programming languages the most efficient one for CAD development, employing the numerical analytical boundary elements method algorithm, is the Java language. This language provides tools not only for development of calculating CAD part, but also to build the graphic interface for geometrical models construction and calculated results interpretation.

  2. Chemometrics-based process analytical technology (PAT) tools: applications and adaptation in pharmaceutical and biopharmaceutical industries.

    Science.gov (United States)

    Challa, Shruthi; Potumarthi, Ravichandra

    2013-01-01

    Process analytical technology (PAT) is used to monitor and control critical process parameters in raw materials and in-process products to maintain the critical quality attributes and build quality into the product. Process analytical technology can be successfully implemented in pharmaceutical and biopharmaceutical industries not only to impart quality into the products but also to prevent out-of-specifications and improve the productivity. PAT implementation eliminates the drawbacks of traditional methods which involves excessive sampling and facilitates rapid testing through direct sampling without any destruction of sample. However, to successfully adapt PAT tools into pharmaceutical and biopharmaceutical environment, thorough understanding of the process is needed along with mathematical and statistical tools to analyze large multidimensional spectral data generated by PAT tools. Chemometrics is a chemical discipline which incorporates both statistical and mathematical methods to obtain and analyze relevant information from PAT spectral tools. Applications of commonly used PAT tools in combination with appropriate chemometric method along with their advantages and working principle are discussed. Finally, systematic application of PAT tools in biopharmaceutical environment to control critical process parameters for achieving product quality is diagrammatically represented.

  3. Surveillance of emerging drugs of abuse in Hong Kong: validation of an analytical tool.

    Science.gov (United States)

    Tang, Magdalene H Y; Ching, C K; Tse, M L; Ng, Carol; Lee, Caroline; Chong, Y K; Wong, Watson; Mak, Tony W L

    2015-04-01

    To validate a locally developed chromatography-based method to monitor emerging drugs of abuse whilst performing regular drug testing in abusers. Cross-sectional study. Eleven regional hospitals, seven social service units, and a tertiary level clinical toxicology laboratory in Hong Kong. A total of 972 drug abusers and high-risk individuals were recruited from acute, rehabilitation, and high-risk settings between 1 November 2011 and 31 July 2013. A subset of the participants was of South Asian ethnicity. In total, 2000 urine or hair specimens were collected. Proof of concept that surveillance of emerging drugs of abuse can be performed whilst conducting routine drug of abuse testing in patients. The method was successfully applied to 2000 samples with three emerging drugs of abuse detected in five samples: PMMA (paramethoxymethamphetamine), TFMPP [1-(3-trifluoromethylphenyl)piperazine], and methcathinone. The method also detected conventional drugs of abuse, with codeine, methadone, heroin, methamphetamine, and ketamine being the most frequently detected drugs. Other findings included the observation that South Asians had significantly higher rates of using opiates such as heroin, methadone, and codeine; and that ketamine and cocaine had significantly higher detection rates in acute subjects compared with the rehabilitation population. This locally developed analytical method is a valid tool for simultaneous surveillance of emerging drugs of abuse and routine drug monitoring of patients at minimal additional cost and effort. Continued, proactive surveillance and early identification of emerging drugs will facilitate prompt clinical, social, and legislative management.

  4. Developing a Modeling Tool Using Eclipse

    NARCIS (Netherlands)

    Kirtley, Nick; Waqas Kamal, Ahmad; Avgeriou, Paris

    2008-01-01

    Tool development using an open source platform provides autonomy to users to change, use, and develop cost-effective software with freedom from licensing requirements. However, open source tool development poses a number of challenges, such as poor documentation and continuous evolution. In this

  5. Capitalizing on App Development Tools and Technologies

    Science.gov (United States)

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    Instructional developers and others creating apps must choose from a wide variety of app development tools and technologies. Some app development tools have incorporated visual programming features, which enable some drag and drop coding and contextual programming. While those features help novices begin programming with greater ease, questions…

  6. Culture and Development : An Analytical Framework

    NARCIS (Netherlands)

    Francois, P.; Zabojnik, J.

    2001-01-01

    This paper develops a framework which analyzes how a population's culture affects the decisions of rational profit maximizing firms, while simultaneously exploring how the actions of these firms in turn affect the population's culture.By endogenizing culture as well as the more usual economic

  7. EPIPOI: A user-friendly analytical tool for the extraction and visualization of temporal parameters from epidemiological time series

    Directory of Open Access Journals (Sweden)

    Alonso Wladimir J

    2012-11-01

    Full Text Available Abstract Background There is an increasing need for processing and understanding relevant information generated by the systematic collection of public health data over time. However, the analysis of those time series usually requires advanced modeling techniques, which are not necessarily mastered by staff, technicians and researchers working on public health and epidemiology. Here a user-friendly tool, EPIPOI, is presented that facilitates the exploration and extraction of parameters describing trends, seasonality and anomalies that characterize epidemiological processes. It also enables the inspection of those parameters across geographic regions. Although the visual exploration and extraction of relevant parameters from time series data is crucial in epidemiological research, until now it had been largely restricted to specialists. Methods EPIPOI is freely available software developed in Matlab (The Mathworks Inc that runs both on PC and Mac computers. Its friendly interface guides users intuitively through useful comparative analyses including the comparison of spatial patterns in temporal parameters. Results EPIPOI is able to handle complex analyses in an accessible way. A prototype has already been used to assist researchers in a variety of contexts from didactic use in public health workshops to the main analytical tool in published research. Conclusions EPIPOI can assist public health officials and students to explore time series data using a broad range of sophisticated analytical and visualization tools. It also provides an analytical environment where even advanced users can benefit by enabling a higher degree of control over model assumptions, such as those associated with detecting disease outbreaks and pandemics.

  8. Observation Tools for Professional Development

    Science.gov (United States)

    Malu, Kathleen F.

    2015-01-01

    Professional development of teachers, including English language teachers, empowers them to change in ways that improve teaching and learning (Gall and Acheson 2011; Murray 2010). In their seminal research on staff development--professional development in today's terms--Joyce and Showers (2002) identify key factors that promote teacher change.…

  9. Analytical and Empirical Modeling of Wear and Forces of CBN Tool in Hard Turning - A Review

    Science.gov (United States)

    Patel, Vallabh Dahyabhai; Gandhi, Anishkumar Hasmukhlal

    2017-08-01

    Machining of steel material having hardness above 45 HRC (Hardness-Rockwell C) is referred as a hard turning. There are numerous models which should be scrutinized and implemented to gain optimum performance of hard turning. Various models in hard turning by cubic boron nitride tool have been reviewed, in attempt to utilize appropriate empirical and analytical models. Validation of steady state flank and crater wear model, Usui's wear model, forces due to oblique cutting theory, extended Lee and Shaffer's force model, chip formation and progressive flank wear have been depicted in this review paper. Effort has been made to understand the relationship between tool wear and tool force based on the different cutting conditions and tool geometries so that appropriate model can be used according to user requirement in hard turning.

  10. Analytics for smart energy management tools and applications for sustainable manufacturing

    CERN Document Server

    Oh, Seog-Chan

    2016-01-01

    This book introduces the issues and problems that arise when implementing smart energy management for sustainable manufacturing in the automotive manufacturing industry and the analytical tools and applications to deal with them. It uses a number of illustrative examples to explain energy management in automotive manufacturing, which involves most types of manufacturing technology and various levels of energy consumption. It demonstrates how analytical tools can help improve energy management processes, including forecasting, consumption, and performance analysis, emerging new technology identification as well as investment decisions for establishing smart energy consumption practices. It also details practical energy management systems, making it a valuable resource for professionals involved in real energy management processes, and allowing readers to implement the procedures and applications presented.

  11. Time-resolved fluorescence microscopy (FLIM) as an analytical tool in skin nanomedicine.

    Science.gov (United States)

    Alexiev, Ulrike; Volz, Pierre; Boreham, Alexander; Brodwolf, Robert

    2017-07-01

    The emerging field of nanomedicine provides new approaches for the diagnosis and treatment of diseases, for symptom relief, and for monitoring of disease progression. Topical application of drug-loaded nanoparticles for the treatment of skin disorders is a promising strategy to overcome the stratum corneum, the upper layer of the skin, which represents an effective physical and biochemical barrier. The understanding of drug penetration into skin and enhanced penetration into skin facilitated by nanocarriers requires analytical tools that ideally allow to visualize the skin, its morphology, the drug carriers, drugs, their transport across the skin and possible interactions, as well as effects of the nanocarriers within the different skin layers. Here, we review some recent developments in the field of fluorescence microscopy, namely Fluorescence Lifetime Imaging Microscopy (FLIM)), for improved characterization of nanocarriers, their interactions and penetration into skin. In particular, FLIM allows for the discrimination of target molecules, e.g. fluorescently tagged nanocarriers, against the autofluorescent tissue background and, due to the environmental sensitivity of the fluorescence lifetime, also offers insights into the local environment of the nanoparticle and its interactions with other biomolecules. Thus, FLIM shows the potential to overcome several limits of intensity based microscopy. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Fourier transform ion cyclotron resonance mass spectrometry: the analytical tool for heavy oil and bitumen characterization

    Energy Technology Data Exchange (ETDEWEB)

    Oldenburg, Thomas B.P; Brown, Melisa; Hsieh, Ben; Larter, Steve [Petroleum Reservoir Group (prg), Department of Geoscience, University of Calgary, Alberta (Canada)

    2011-07-01

    The Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICRMS), developed in the 1970's by Marshall and Comisarow at the University of British Columbia, has become a commercially available tool capable of analyzing several hundred thousand components in a petroleum mixture at once. This analytical technology will probably usher a dramatic revolution in geochemical capability, equal to or greater than the molecular revolution that occurred when GCMS technologies became cheaply available. The molecular resolution and information content given by the FTICRMS petroleum analysis can be compared to the information in the human genome. With current GCMS-based petroleum geochemical protocols perhaps a few hundred components can be quantitatively determined, but with FTICRMS, 1000 times this number of components could possibly be resolved. However, fluid and other properties depend on interaction of this multitude of hydrocarbon and non-hydrocarbon components, not the components themselves, and access to the full potential of this new petroleomics will depend on the definition of this interactome.

  13. The 'secureplan' bomb utility: A PC-based analytic tool for bomb defense

    International Nuclear Information System (INIS)

    Massa, R.J.

    1987-01-01

    This paper illustrates a recently developed, PC-based software system for simulating the effects of an infinite variety of hypothetical bomb blasts on structures and personnel in the immediate vicinity of such blasts. The system incorporates two basic rectangular geometries in which blast assessments can be made - an external configuration (highly vented) and an internal configuration (vented and unvented). A variety of explosives can be used - each is translated to an equivalent TNT weight. Provisions in the program account for bomb cases (person, satchel, case and vehicle), mixes of explosives and shrapnel aggregates and detonation altitudes. The software permits architects, engineers, security personnel and facility managers, without specific knowledge of explosives, to incorporate realistic construction hardening, screening programs, barriers and stand-off provisions in the design and/or operation of diverse facilities. System outputs - generally represented as peak incident or reflected overpressure or impulses - are both graphic and analytic and integrate damage threshold data for common construction materials including window glazing. The effects of bomb blasts on humans is estimated in terms of temporary and permanent hearing damage, lung damage (lethality) and whole body translation injury. The software system has been used in the field in providing bomb defense services to a number of commercial clients since July of 1986. In addition to the design of siting, screening and hardening components of bomb defense programs, the software has proven very useful in post-incident analysis and repair scenarios and as a teaching tool for bomb defense training

  14. Impact of population and economic growth on carbon emissions in Taiwan using an analytic tool STIRPAT

    Directory of Open Access Journals (Sweden)

    Jong-Chao Yeh

    2017-01-01

    Full Text Available Carbon emission has increasingly become an issue of global concern because of climate change. Unfortunately, Taiwan was listed as top 20 countries of carbon emission in 2014. In order to provide appropriate measures to control carbon emission, it appears that there is an urgent need to address how such factors as population and economic growth impact the emission of carbon dioxide in any developing countries. In addition to total population, both the percentages of population living in urban area (i.e., urbanization percentage, and non-dependent population may also serve as limiting factors. On the other hand, the total energy-driven gross domestic production (GDP and the percentage of GDP generated by the manufacturing industries are assessed to see their respective degree of impact on carbon emission. Therefore, based on the past national data in the period 1990–2014 in Taiwan, an analytic tool of Stochastic Impacts by Regression on Population, Affluence and Technology (STIRPAT was employed to see how well those aforementioned factors can describe their individual potential impact on global warming, which is measured by the total amount of carbon emission into the atmosphere. Seven scenarios of STIRPAT model were proposed and tested statistically for the significance of each proposed model. As a result, two models were suggested to predict the impact of carbon emission due to population and economic growth by the year 2025 in Taiwan.

  15. Experiments with Analytic Centers: A confluence of data, tools and help in using them.

    Science.gov (United States)

    Little, M. M.; Crichton, D. J.; Hines, K.; Cole, M.; Quam, B. M.

    2017-12-01

    Traditional repositories have been primarily focused on data stewardship. Over the past two decades, data scientists have attempted to overlay a superstructure to make these repositories more amenable to analysis tasks, with limited success. This poster will summarize lessons learned and some realizations regarding what it takes to create an analytic center. As the volume of Earth Science data grows and the sophistication of analytic tools improves, a pattern has emerged that indicates different science communities uniquely apply a selection of tools to the data to produce scientific results. Infrequently do the experiences of one group help steer other groups. How can the information technology community seed these domains with tools that conform to the thought processes and experiences of that particular science group? What types of succcessful technology infusions have occured and how does technology get adopted. AIST has been experimenting with the management of this analytic center process; this paper will summarize the results and indicate a direction for future infusion attempts.

  16. Development tool for PHP programs

    OpenAIRE

    Karlsen, Håkon Skaarud

    2005-01-01

    This paper discusses how a PHP development toolbox can be implemented. One toolbox has been implemented, and the implementation is described and documented in the text. The toolbox is primarily meant to help students who are taking a System Development course (INF1050) at the University of Oslo with the implementation phase of a software engineering project, but other PHP programmers may also benefit from using the toolbox. It has been emphasized that the programming interface should be i...

  17. Topological data analysis: A promising big data exploration tool in biology, analytical chemistry and physical chemistry.

    Science.gov (United States)

    Offroy, Marc; Duponchel, Ludovic

    2016-03-03

    An important feature of experimental science is that data of various kinds is being produced at an unprecedented rate. This is mainly due to the development of new instrumental concepts and experimental methodologies. It is also clear that the nature of acquired data is significantly different. Indeed in every areas of science, data take the form of always bigger tables, where all but a few of the columns (i.e. variables) turn out to be irrelevant to the questions of interest, and further that we do not necessary know which coordinates are the interesting ones. Big data in our lab of biology, analytical chemistry or physical chemistry is a future that might be closer than any of us suppose. It is in this sense that new tools have to be developed in order to explore and valorize such data sets. Topological data analysis (TDA) is one of these. It was developed recently by topologists who discovered that topological concept could be useful for data analysis. The main objective of this paper is to answer the question why topology is well suited for the analysis of big data set in many areas and even more efficient than conventional data analysis methods. Raman analysis of single bacteria should be providing a good opportunity to demonstrate the potential of TDA for the exploration of various spectroscopic data sets considering different experimental conditions (with high noise level, with/without spectral preprocessing, with wavelength shift, with different spectral resolution, with missing data). Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Benefits and limitations of using decision analytic tools to assess uncertainty and prioritize Landscape Conservation Cooperative information needs

    Science.gov (United States)

    Post van der Burg, Max; Cullinane Thomas, Catherine; Holcombe, Tracy R.; Nelson, Richard D.

    2016-01-01

    The Landscape Conservation Cooperatives (LCCs) are a network of partnerships throughout North America that are tasked with integrating science and management to support more effective delivery of conservation at a landscape scale. In order to achieve this integration, some LCCs have adopted the approach of providing their partners with better scientific information in an effort to facilitate more effective and coordinated conservation decisions. Taking this approach has led many LCCs to begin funding research to provide the information for improved decision making. To ensure that funding goes to research projects with the highest likelihood of leading to more integrated broad scale conservation, some LCCs have also developed approaches for prioritizing which information needs will be of most benefit to their partnerships. We describe two case studies in which decision analytic tools were used to quantitatively assess the relative importance of information for decisions made by partners in the Plains and Prairie Potholes LCC. The results of the case studies point toward a few valuable lessons in terms of using these tools with LCCs. Decision analytic tools tend to help shift focus away from research oriented discussions and toward discussions about how information is used in making better decisions. However, many technical experts do not have enough knowledge about decision making contexts to fully inform the latter type of discussion. When assessed in the right decision context, however, decision analyses can point out where uncertainties actually affect optimal decisions and where they do not. This helps technical experts understand that not all research is valuable in improving decision making. But perhaps most importantly, our results suggest that decision analytic tools may be more useful for LCCs as way of developing integrated objectives for coordinating partner decisions across the landscape, rather than simply ranking research priorities.

  19. Development of analytical techniques for safeguards environmental samples at JAEA

    International Nuclear Information System (INIS)

    Sakurai, Satoshi; Magara, Masaaki; Usuda, Shigekazu; Watanabe, Kazuo; Esaka, Fumitaka; Hirayama, Fumio; Lee, Chi-Gyu; Yasuda, Kenichiro; Inagawa, Jun; Suzuki, Daisuke; Iguchi, Kazunari; Kokubu, Yoko S.; Miyamoto, Yutaka; Ohzu, Akira

    2007-01-01

    JAEA has been developing, under the auspices of the Ministry of Education, Culture, Sports, Science and Technology of Japan, analytical techniques for ultra-trace amounts of nuclear materials in environmental samples in order to contribute to the strengthened safeguards system. Development of essential techniques for bulk and particle analysis, as well as screening, of the environmental swipe samples has been established as ultra-trace analytical methods of uranium and plutonium. In January 2003, JAEA was qualified, including its quality control system, as a member of the JAEA network analytical laboratories for environmental samples. Since 2004, JAEA has conducted the analysis of domestic and the IAEA samples, through which JAEA's analytical capability has been verified and improved. In parallel, advanced techniques have been developed in order to expand the applicability to the samples of various elemental composition and impurities and to improve analytical accuracy and efficiency. This paper summarizes the trace of the technical development in environmental sample analysis at JAEA, and refers to recent trends of research and development in this field. (author)

  20. Development and Validation of Analytical Method for Losartan ...

    African Journals Online (AJOL)

    Development and Validation of Analytical Method for Losartan-Copper Complex Using UV-Vis Spectrophotometry. ... Tropical Journal of Pharmaceutical Research ... Purpose: To develop a new spectrophotometric method for the analysis of losartan potassium in pharmaceutical formulations by making its complex with ...

  1. Development of analytical cell support for vitrification at the West Valley Demonstration Project. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Barber, F.H.; Borek, T.T.; Christopher, J.Z. [and others

    1997-12-01

    Analytical and Process Chemistry (A&PC) support is essential to the high-level waste vitrification campaign at the West Valley Demonstration Project (WVDP). A&PC characterizes the waste, providing information necessary to formulate the recipe for the target radioactive glass product. High-level waste (HLW) samples are prepared and analyzed in the analytical cells (ACs) and Sample Storage Cell (SSC) on the third floor of the main plant. The high levels of radioactivity in the samples require handling them in the shielded cells with remote manipulators. The analytical hot cells and third floor laboratories were refurbished to ensure optimal uninterrupted operation during the vitrification campaign. New and modified instrumentation, tools, sample preparation and analysis techniques, and equipment and training were required for A&PC to support vitrification. Analytical Cell Mockup Units (ACMUs) were designed to facilitate method development, scientist and technician training, and planning for analytical process flow. The ACMUs were fabricated and installed to simulate the analytical cell environment and dimensions. New techniques, equipment, and tools could be evaluated m in the ACMUs without the consequences of generating or handling radioactive waste. Tools were fabricated, handling and disposal of wastes was addressed, and spatial arrangements for equipment were refined. As a result of the work at the ACMUs the remote preparation and analysis methods and the equipment and tools were ready for installation into the ACs and SSC m in July 1995. Before use m in the hot cells, all remote methods had been validated and four to eight technicians were trained on each. Fine tuning of the procedures has been ongoing at the ACs based on input from A&PC technicians. Working at the ACs presents greater challenges than had development at the ACMUs. The ACMU work and further refinements m in the ACs have resulted m in a reduction m in analysis turnaround time (TAT).

  2. Development of analytical cell support for vitrification at the West Valley Demonstration Project. Topical report

    International Nuclear Information System (INIS)

    Barber, F.H.; Borek, T.T.; Christopher, J.Z.

    1997-12-01

    Analytical and Process Chemistry (A ampersand PC) support is essential to the high-level waste vitrification campaign at the West Valley Demonstration Project (WVDP). A ampersand PC characterizes the waste, providing information necessary to formulate the recipe for the target radioactive glass product. High-level waste (HLW) samples are prepared and analyzed in the analytical cells (ACs) and Sample Storage Cell (SSC) on the third floor of the main plant. The high levels of radioactivity in the samples require handling them in the shielded cells with remote manipulators. The analytical hot cells and third floor laboratories were refurbished to ensure optimal uninterrupted operation during the vitrification campaign. New and modified instrumentation, tools, sample preparation and analysis techniques, and equipment and training were required for A ampersand PC to support vitrification. Analytical Cell Mockup Units (ACMUs) were designed to facilitate method development, scientist and technician training, and planning for analytical process flow. The ACMUs were fabricated and installed to simulate the analytical cell environment and dimensions. New techniques, equipment, and tools could be evaluated m in the ACMUs without the consequences of generating or handling radioactive waste. Tools were fabricated, handling and disposal of wastes was addressed, and spatial arrangements for equipment were refined. As a result of the work at the ACMUs the remote preparation and analysis methods and the equipment and tools were ready for installation into the ACs and SSC m in July 1995. Before use m in the hot cells, all remote methods had been validated and four to eight technicians were trained on each. Fine tuning of the procedures has been ongoing at the ACs based on input from A ampersand PC technicians. Working at the ACs presents greater challenges than had development at the ACMUs. The ACMU work and further refinements m in the ACs have resulted m in a reduction m in

  3. Earth Science Data Analytics: Bridging Tools and Techniques with the Co-Analysis of Large, Heterogeneous Datasets

    Science.gov (United States)

    Kempler, Steve; Mathews, Tiffany

    2016-01-01

    The continuum of ever-evolving data management systems affords great opportunities to the enhancement of knowledge and facilitation of science research. To take advantage of these opportunities, it is essential to understand and develop methods that enable data relationships to be examined and the information to be manipulated. This presentation describes the efforts of the Earth Science Information Partners (ESIP) Federation Earth Science Data Analytics (ESDA) Cluster to understand, define, and facilitate the implementation of ESDA to advance science research. As a result of the void of Earth science data analytics publication material, the cluster has defined ESDA along with 10 goals to set the framework for a common understanding of tools and techniques that are available and still needed to support ESDA.

  4. Electrochemical immunoassay using magnetic beads for the determination of zearalenone in baby food: an anticipated analytical tool for food safety.

    Science.gov (United States)

    Hervás, Miriam; López, Miguel Angel; Escarpa, Alberto

    2009-10-27

    In this work, electrochemical immunoassay involving magnetic beads to determine zearalenone in selected food samples has been developed. The immunoassay scheme has been based on a direct competitive immunoassay method in which antibody-coated magnetic beads were employed as the immobilisation support and horseradish peroxidase (HRP) was used as enzymatic label. Amperometric detection has been achieved through the addition of hydrogen peroxide substrate and hydroquinone as mediator. Analytical performance of the electrochemical immunoassay has been evaluated by analysis of maize certified reference material (CRM) and selected baby food samples. A detection limit (LOD) of 0.011 microg L(-1) and EC(50) 0.079 microg L(-1) were obtained allowing the assessment of the detection of zearalenone mycotoxin. In addition, an excellent accuracy with a high recovery yield ranging between 95 and 108% has been obtained. The analytical features have shown the proposed electrochemical immunoassay to be a very powerful and timely screening tool for the food safety scene.

  5. Quality Assurance Project Plan Development Tool

    Science.gov (United States)

    This tool contains information designed to assist in developing a Quality Assurance (QA) Project Plan that meets EPA requirements for projects that involve surface or groundwater monitoring and/or the collection and analysis of water samples.

  6. Developing a Parametric Urban Design Tool

    DEFF Research Database (Denmark)

    Steinø, Nicolai; Obeling, Esben

    2014-01-01

    Parametric urban design is a potentially powerful tool for collaborative urban design processes. Rather than making one- off designs which need to be redesigned from the ground up in case of changes, parametric design tools make it possible keep the design open while at the same time allowing...... for a level of detailing which is high enough to facilitate an understan- ding of the generic qualities of proposed designs. Starting from a brief overview of parametric design, this paper presents initial findings from the development of a parametric urban design tool with regard to developing a structural...... logic which is flexible and expandable. It then moves on to outline and discuss further development work. Finally, it offers a brief reflection on the potentials and shortcomings of the software – CityEngine – which is used for developing the parametric urban design tool....

  7. Data Mining and Optimization Tools for Developing Engine Parameters Tools

    Science.gov (United States)

    Dhawan, Atam P.

    1998-01-01

    This project was awarded for understanding the problem and developing a plan for Data Mining tools for use in designing and implementing an Engine Condition Monitoring System. Tricia Erhardt and I studied the problem domain for developing an Engine Condition Monitoring system using the sparse and non-standardized datasets to be available through a consortium at NASA Lewis Research Center. We visited NASA three times to discuss additional issues related to dataset which was not made available to us. We discussed and developed a general framework of data mining and optimization tools to extract useful information from sparse and non-standard datasets. These discussions lead to the training of Tricia Erhardt to develop Genetic Algorithm based search programs which were written in C++ and used to demonstrate the capability of GA algorithm in searching an optimal solution in noisy, datasets. From the study and discussion with NASA LeRC personnel, we then prepared a proposal, which is being submitted to NASA for future work for the development of data mining algorithms for engine conditional monitoring. The proposed set of algorithm uses wavelet processing for creating multi-resolution pyramid of tile data for GA based multi-resolution optimal search.

  8. Manuscript title: antifungal proteins from moulds: analytical tools and potential application to dry-ripened foods.

    Science.gov (United States)

    Delgado, Josué; Owens, Rebecca A; Doyle, Sean; Asensio, Miguel A; Núñez, Félix

    2016-08-01

    Moulds growing on the surface of dry-ripened foods contribute to their sensory qualities, but some of them are able to produce mycotoxins that pose a hazard to consumers. Small cysteine-rich antifungal proteins (AFPs) from moulds are highly stable to pH and proteolysis and exhibit a broad inhibition spectrum against filamentous fungi, providing new chances to control hazardous moulds in fermented foods. The analytical tools for characterizing the cellular targets and affected pathways are reviewed. Strategies currently employed to study these mechanisms of action include 'omics' approaches that have come to the forefront in recent years, developing in tandem with genome sequencing of relevant organisms. These techniques contribute to a better understanding of the response of moulds against AFPs, allowing the design of complementary strategies to maximize or overcome the limitations of using AFPs on foods. AFPs alter chitin biosynthesis, and some fungi react inducing cell wall integrity (CWI) pathway. However, moulds able to increase chitin content at the cell wall by increasing proteins in either CWI or calmodulin-calcineurin signalling pathways will resist AFPs. Similarly, AFPs increase the intracellular levels of reactive oxygen species (ROS), and moulds increasing G-protein complex β subunit CpcB and/or enzymes to efficiently produce glutathione may evade apoptosis. Unknown aspects that need to be addressed include the interaction with mycotoxin production by less sensitive toxigenic moulds. However, significant steps have been taken to encourage the use of AFPs in intermediate-moisture foods, particularly for mould-ripened cheese and meat products.

  9. Comparison of Left Ventricular Hypertrophy by Electrocardiography and Echocardiography in Children Using Analytics Tool.

    Science.gov (United States)

    Tague, Lauren; Wiggs, Justin; Li, Qianxi; McCarter, Robert; Sherwin, Elizabeth; Weinberg, Jacqueline; Sable, Craig

    2018-05-17

    Left ventricular hypertrophy (LVH) is a common finding on pediatric electrocardiography (ECG) leading to many referrals for echocardiography (echo). This study utilizes a novel analytics tool that combines ECG and echo databases to evaluate ECG as a screening tool for LVH. SQL Server 2012 data warehouse incorporated ECG and echo databases for all patients from a single institution from 2006 to 2016. Customized queries identified patients 0-18 years old with LVH on ECG and an echo performed within 24 h. Using data visualization (Tableau) and analytic (Stata 14) software, ECG and echo findings were compared. Of 437,699 encounters, 4637 met inclusion criteria. ECG had high sensitivity (≥ 90%) but poor specificity (43%), and low positive predictive value (< 20%) for echo abnormalities. ECG performed only 11-22% better than chance (AROC = 0.50). 83% of subjects with LVH on ECG had normal left ventricle (LV) structure and size on echo. African-Americans with LVH were least likely to have an abnormal echo. There was a low correlation between V 6 R on ECG and echo-derived Z score of left ventricle diastolic diameter (r = 0.14) and LV mass index (r = 0.24). The data analytics client was able to mine a database of ECG and echo reports, comparing LVH by ECG and LV measurements and qualitative findings by echo, identifying an abnormal LV by echo in only 17% of cases with LVH on ECG. This novel tool is useful for rapid data mining for both clinical and research endeavors.

  10. ANALYTICAL MODEL FOR LATHE TOOL DISPLACEMENTS CALCULUS IN THE MANUFACTURING P ROCESS

    Directory of Open Access Journals (Sweden)

    Catălin ROŞU

    2014-01-01

    Full Text Available In this paper, we present an analytical model for lathe tools displacements calculus in the manufacturing process. We will present step by step the methodology for the displacements calculus and in the end we will insert these relations in a program for automatic calculus and we extract the conclusions. There is taken into account only the effects of the bending moments (because these insert the highest displacements. The simplifying assumptions and the calculus relations for the displacements (linea r and angular ones are presented in an original way.

  11. Predictive analytics tools to adjust and monitor performance metrics for the ATLAS Production System

    CERN Document Server

    Barreiro Megino, Fernando Harald; The ATLAS collaboration

    2017-01-01

    Having information such as an estimation of the processing time or possibility of system outage (abnormal behaviour) helps to assist to monitor system performance and to predict its next state. The current cyber-infrastructure presents computing conditions in which contention for resources among high-priority data analysis happens routinely, that might lead to significant workload and data handling interruptions. The lack of the possibility to monitor and to predict the behaviour of the analysis process (its duration) and system’s state itself caused to focus on design of the built-in situational awareness analytic tools.

  12. Development of remote handling tools and equipment

    International Nuclear Information System (INIS)

    Nakahira, Masataka; Oka, Kiyoshi; Taguchi, Kou; Ito, Akira; Fukatsu, Seiichi; Oda, Yasushi; Kajiura, Soji; Yamazaki, Seiichiro; Aoyama, Kazuo.

    1997-01-01

    The remote handling (RH) tools and equipment development in ITER focuses mainly on the welding and cutting technique, weld inspection and double-seal door which are essential factors in the replacement of in-vessel components such as divertor and blanket. The conceptual design of these RH tools and equipment has been defined through ITER engineering design activity (EDA). Similarly, elementary R and D of the RH tools and equipment have been extensively performed to accumulate a technological data base for process and performance qualification. Based on this data, fabrications of full-scale RH tools and equipment are under progress. A prototypical bore tool for pipe welding and cutting has already been fabricated and is currently undergoing integrated performance tests. This paper describes the design outline of the RH tools and equipment related to in-vessel components maintenance, and highlights the current status of RH tools and equipment development by the Japan Home Team as an ITER R and D program. This paper also includes an outline of insulation joint and quick-pipe connector development, which has also been conducted through the ITER R and D program in order to standardize RH operations and components. (author)

  13. Remote tool development for nuclear dismantling operations

    International Nuclear Information System (INIS)

    Craig, G.; Ferlay, J.C.; Ieracitano, F.

    2003-01-01

    Remote tool systems to undertake nuclear dismantling operations require careful design and development not only to perform their given duty but to perform it safely within the constraints imposed by harsh environmental conditions. Framatome ANP NUCLEAR SERVICES has for a long time developed and qualified equipment to undertake specific maintenance operations of nuclear reactors. The tool development methodology from this activity has since been adapted to resolve some very challenging reactor dismantling operations which are demonstrated in this paper. Each nuclear decommissioning project is a unique case, technical characterisation data is generally incomplete. The development of the dismantling methodology and associated equipment is by and large an iterative process combining design and simulation with feasibility and validation testing. The first stage of the development process involves feasibility testing of industrial tools and examining adaptations necessary to control and deploy the tool remotely with respect to the chosen methodology and environmental constraints. This results in a prototype tool and deployment system to validate the basic process. The second stage involves detailed design which integrates any remaining technical and environmental constraints. At the end of this stage, tools and deployment systems, operators and operating procedures are qualified on full scale mock ups. (authors)

  14. Developing an Evaluation Framework of Quality Indicators for Learning Analytics

    NARCIS (Netherlands)

    Scheffel, Maren; Drachsler, Hendrik; Specht, Marcus

    2017-01-01

    This paper presents results from the continuous process of developing an evaluation framework of quality indicators for learning analytics (LA). Building on a previous study, a group concept mapping approach that uses multidimensional scaling and hierarchical clustering, the study presented here

  15. Recent developments in analytical toxicology : for better or for worse

    NARCIS (Netherlands)

    de Zeeuw, RA

    1998-01-01

    When considering the state of the art in toxicology from an analytical perspective, the key developments relate to three major areas. (1) Forensic horizon: Today forensic analysis has broadened its scope dramatically, to include workplace toxicology, drug abuse testing, drugs and driving, doping,

  16. Analytical tools for thermal infrared engineerig: a thermal sensor simulation package

    Science.gov (United States)

    Jaggi, Sandeep

    1992-09-01

    The Advanced Sensor Development Laboratory (ASDL) at the Stennis Space Center develops, maintains and calibrates remote sensing instruments for the National Aeronautics & Space Administration. To perform system design trade-offs, analysis, and establish system parameters, ASDL has developed a software package for analytical simulation of sensor systems. This package called 'Analytical Tools for Thermal InfraRed Engineering'--ATTIRE, simulates the various components of a sensor system. The software allows each subsystem of the sensor to be analyzed independently for its performance. These performance parameters are then integrated to obtain system level information such as SNR, NER, NETD etc. This paper describes the uses of the package and the physics that were used to derive the performance parameters. In addition, ATTIRE can be used as a tutorial for understanding the distribution of thermal flux or solar irradiance over selected bandwidths of the spectrum. This spectrally distributed incident flux can then be analyzed as it propagates through the subsystems that constitute the entire sensor. ATTIRE provides a variety of functions ranging from plotting black-body curves for varying bandwidths and computing the integral flux, to performing transfer function analysis of the sensor system. The package runs from a menu- driven interface in a PC-DOS environment. Each sub-system of the sensor is represented by windows and icons. A user-friendly mouse-controlled point-and-click interface allows the user to simulate various aspects of a sensor. The package can simulate a theoretical sensor system. Trade-off studies can be easily done by changing the appropriate parameters and monitoring the effect of the system performance. The package can provide plots of system performance versus any system parameter. A parameter (such as the entrance aperture of the optics) could be varied and its effect on another parameter (e.g., NETD) can be plotted. A third parameter (e.g., the

  17. XCluSim: a visual analytics tool for interactively comparing multiple clustering results of bioinformatics data

    Science.gov (United States)

    2015-01-01

    Background Though cluster analysis has become a routine analytic task for bioinformatics research, it is still arduous for researchers to assess the quality of a clustering result. To select the best clustering method and its parameters for a dataset, researchers have to run multiple clustering algorithms and compare them. However, such a comparison task with multiple clustering results is cognitively demanding and laborious. Results In this paper, we present XCluSim, a visual analytics tool that enables users to interactively compare multiple clustering results based on the Visual Information Seeking Mantra. We build a taxonomy for categorizing existing techniques of clustering results visualization in terms of the Gestalt principles of grouping. Using the taxonomy, we choose the most appropriate interactive visualizations for presenting individual clustering results from different types of clustering algorithms. The efficacy of XCluSim is shown through case studies with a bioinformatician. Conclusions Compared to other relevant tools, XCluSim enables users to compare multiple clustering results in a more scalable manner. Moreover, XCluSim supports diverse clustering algorithms and dedicated visualizations and interactions for different types of clustering results, allowing more effective exploration of details on demand. Through case studies with a bioinformatics researcher, we received positive feedback on the functionalities of XCluSim, including its ability to help identify stably clustered items across multiple clustering results. PMID:26328893

  18. Development of a transportation planning tool

    International Nuclear Information System (INIS)

    Funkhouser, B.R.; Moyer, J.W.; Ballweg, E.L.

    1994-01-01

    This paper describes the application of simulation modeling and logistics techniques to the development of a planning tool for the Department of Energy (DOE). The focus of the Transportation Planning Model (TPM) tool is to aid DOE and Sandia analysts in the planning of future fleet sizes, driver and support personnel sizes, base site locations, and resource balancing among the base sites. The design approach is to develop a rapid modeling environment which will allow analysts to easily set up a shipment scenario and perform multiple ''what if'' evaluations. The TPM is being developed on personal computers using commercial off-the shelf (COTS) software tools under the WINDOWS reg-sign operating environment. Prototype development of the TPM has been completed

  19. Information technology tools for curriculum development

    NARCIS (Netherlands)

    McKenney, Susan; Nieveen, N.M.; Strijker, A.; Voogt, Joke; Knezek, Gerald

    2008-01-01

    The widespread introduction and use of computers in the workplace began in the early 1990s. Since then, computer-based tools have been developed to support a myriad of task types, including the complex process of curriculum development. This chapter begins by briefly introducing two concepts that

  20. Database development tool DELPHI and its application

    International Nuclear Information System (INIS)

    Ma Mei

    2000-01-01

    The authors described the progress of the software development technologies and tools, the features and performances of Borland Delphi and a software development instance which is the Management Information System of Tank region storage and transportation control center for Zhenhai Refining and Chemical CO., Ltd. in the Zhejiang province

  1. Visualization and analytics tools for infectious disease epidemiology: a systematic review.

    Science.gov (United States)

    Carroll, Lauren N; Au, Alan P; Detwiler, Landon Todd; Fu, Tsung-Chieh; Painter, Ian S; Abernethy, Neil F

    2014-10-01

    A myriad of new tools and algorithms have been developed to help public health professionals analyze and visualize the complex data used in infectious disease control. To better understand approaches to meet these users' information needs, we conducted a systematic literature review focused on the landscape of infectious disease visualization tools for public health professionals, with a special emphasis on geographic information systems (GIS), molecular epidemiology, and social network analysis. The objectives of this review are to: (1) identify public health user needs and preferences for infectious disease information visualization tools; (2) identify existing infectious disease information visualization tools and characterize their architecture and features; (3) identify commonalities among approaches applied to different data types; and (4) describe tool usability evaluation efforts and barriers to the adoption of such tools. We identified articles published in English from January 1, 1980 to June 30, 2013 from five bibliographic databases. Articles with a primary focus on infectious disease visualization tools, needs of public health users, or usability of information visualizations were included in the review. A total of 88 articles met our inclusion criteria. Users were found to have diverse needs, preferences and uses for infectious disease visualization tools, and the existing tools are correspondingly diverse. The architecture of the tools was inconsistently described, and few tools in the review discussed the incorporation of usability studies or plans for dissemination. Many studies identified concerns regarding data sharing, confidentiality and quality. Existing tools offer a range of features and functions that allow users to explore, analyze, and visualize their data, but the tools are often for siloed applications. Commonly cited barriers to widespread adoption included lack of organizational support, access issues, and misconceptions about tool

  2. Second International Workshop on Teaching Analytics

    DEFF Research Database (Denmark)

    Vatrapu, Ravi; Reimann, Peter; Halb, Wolfgang

    2013-01-01

    Teaching Analytics is conceived as a subfield of learning analytics that focuses on the design, development, evaluation, and education of visual analytics methods and tools for teachers in primary, secondary, and tertiary educational settings. The Second International Workshop on Teaching Analytics...... (IWTA) 2013 seeks to bring together researchers and practitioners in the fields of education, learning sciences, learning analytics, and visual analytics to investigate the design, development, use, evaluation, and impact of visual analytical methods and tools for teachers’ dynamic diagnostic decision...

  3. Windows Developer Power Tools Turbocharge Windows development with more than 170 free and open source tools

    CERN Document Server

    Avery, James

    2007-01-01

    Software developers need to work harder and harder to bring value to their development process in order to build high quality applications and remain competitive. Developers can accomplish this by improving their productivity, quickly solving problems, and writing better code. A wealth of open source and free software tools are available for developers who want to improve the way they create, build, deploy, and use software. Tools, components, and frameworks exist to help developers at every point in the development process. Windows Developer Power Tools offers an encyclopedic guide to m

  4. Heat as a groundwater tracer in shallow and deep heterogeneous media: Analytical solution, spreadsheet tool, and field applications

    Science.gov (United States)

    Kurylyk, Barret L.; Irvine, Dylan J.; Carey, Sean K.; Briggs, Martin A.; Werkema, Dale D.; Bonham, Mariah

    2017-01-01

    Groundwater flow advects heat, and thus, the deviation of subsurface temperatures from an expected conduction‐dominated regime can be analysed to estimate vertical water fluxes. A number of analytical approaches have been proposed for using heat as a groundwater tracer, and these have typically assumed a homogeneous medium. However, heterogeneous thermal properties are ubiquitous in subsurface environments, both at the scale of geologic strata and at finer scales in streambeds. Herein, we apply the analytical solution of Shan and Bodvarsson (2004), developed for estimating vertical water fluxes in layered systems, in 2 new environments distinct from previous vadose zone applications. The utility of the solution for studying groundwater‐surface water exchange is demonstrated using temperature data collected from an upwelling streambed with sediment layers, and a simple sensitivity analysis using these data indicates the solution is relatively robust. Also, a deeper temperature profile recorded in a borehole in South Australia is analysed to estimate deeper water fluxes. The analytical solution is able to match observed thermal gradients, including the change in slope at sediment interfaces. Results indicate that not accounting for layering can yield errors in the magnitude and even direction of the inferred Darcy fluxes. A simple automated spreadsheet tool (Flux‐LM) is presented to allow users to input temperature and layer data and solve the inverse problem to estimate groundwater flux rates from shallow (e.g., regimes.

  5. Identifying problems and generating recommendations for enhancing complex systems: applying the abstraction hierarchy framework as an analytical tool.

    Science.gov (United States)

    Xu, Wei

    2007-12-01

    This study adopts J. Rasmussen's (1985) abstraction hierarchy (AH) framework as an analytical tool to identify problems and pinpoint opportunities to enhance complex systems. The process of identifying problems and generating recommendations for complex systems using conventional methods is usually conducted based on incompletely defined work requirements. As the complexity of systems rises, the sheer mass of data generated from these methods becomes unwieldy to manage in a coherent, systematic form for analysis. There is little known work on adopting a broader perspective to fill these gaps. AH was used to analyze an aircraft-automation system in order to further identify breakdowns in pilot-automation interactions. Four steps follow: developing an AH model for the system, mapping the data generated by various methods onto the AH, identifying problems based on the mapped data, and presenting recommendations. The breakdowns lay primarily with automation operations that were more goal directed. Identified root causes include incomplete knowledge content and ineffective knowledge structure in pilots' mental models, lack of effective higher-order functional domain information displayed in the interface, and lack of sufficient automation procedures for pilots to effectively cope with unfamiliar situations. The AH is a valuable analytical tool to systematically identify problems and suggest opportunities for enhancing complex systems. It helps further examine the automation awareness problems and identify improvement areas from a work domain perspective. Applications include the identification of problems and generation of recommendations for complex systems as well as specific recommendations regarding pilot training, flight deck interfaces, and automation procedures.

  6. Analytic solution to leading order coupled DGLAP evolution equations: A new perturbative QCD tool

    International Nuclear Information System (INIS)

    Block, Martin M.; Durand, Loyal; Ha, Phuoc; McKay, Douglas W.

    2011-01-01

    We have analytically solved the LO perturbative QCD singlet DGLAP equations [V. N. Gribov and L. N. Lipatov, Sov. J. Nucl. Phys. 15, 438 (1972)][G. Altarelli and G. Parisi, Nucl. Phys. B126, 298 (1977)][Y. L. Dokshitzer, Sov. Phys. JETP 46, 641 (1977)] using Laplace transform techniques. Newly developed, highly accurate, numerical inverse Laplace transform algorithms [M. M. Block, Eur. Phys. J. C 65, 1 (2010)][M. M. Block, Eur. Phys. J. C 68, 683 (2010)] allow us to write fully decoupled solutions for the singlet structure function F s (x,Q 2 ) and G(x,Q 2 ) as F s (x,Q 2 )=F s (F s0 (x 0 ),G 0 (x 0 )) and G(x,Q 2 )=G(F s0 (x 0 ),G 0 (x 0 )), where the x 0 are the Bjorken x values at Q 0 2 . Here F s and G are known functions--found using LO DGLAP splitting functions--of the initial boundary conditions F s0 (x)≡F s (x,Q 0 2 ) and G 0 (x)≡G(x,Q 0 2 ), i.e., the chosen starting functions at the virtuality Q 0 2 . For both G(x) and F s (x), we are able to either devolve or evolve each separately and rapidly, with very high numerical accuracy--a computational fractional precision of O(10 -9 ). Armed with this powerful new tool in the perturbative QCD arsenal, we compare our numerical results from the above equations with the published MSTW2008 and CTEQ6L LO gluon and singlet F s distributions [A. D. Martin, W. J. Stirling, R. S. Thorne, and G. Watt, Eur. Phys. J. C 63, 189 (2009)], starting from their initial values at Q 0 2 =1 GeV 2 and 1.69 GeV 2 , respectively, using their choice of α s (Q 2 ). This allows an important independent check on the accuracies of their evolution codes and, therefore, the computational accuracies of their published parton distributions. Our method completely decouples the two LO distributions, at the same time guaranteeing that both G and F s satisfy the singlet coupled DGLAP equations. It also allows one to easily obtain the effects of the starting functions on the evolved gluon and singlet structure functions, as functions of both Q

  7. Development of automated analytical systems for large throughput

    International Nuclear Information System (INIS)

    Ernst, P.C.; Hoffman, E.L.

    1982-01-01

    The need to be able to handle a large throughput of samples for neutron activation analysis has led to the development of automated counting and sample handling systems. These are coupled with available computer-assisted INAA techniques to perform a wide range of analytical services on a commercial basis. A fully automated delayed neutron counting system and a computer controlled pneumatic transfer for INAA use are described, as is a multi-detector gamma-spectroscopy system. (author)

  8. History of a secondary side inspection tooling development

    International Nuclear Information System (INIS)

    Harris, W.

    2012-01-01

    This presentation provides a brief history (1980 to present day) of steam generator secondary side tooling requirements, tooling development, tooling available today and how and where this tooling has been implemented for steam generator secondary side inspections. History of Tooling Development discussion covers the relatively short time period from when the SGSS tooling was required and why as well the associated challenges with development through present day; Available Tooling discussion covers the actual tooling available today, locations in the steam generator where the tooling is used and how the tooling works; Implementation discussion covers where in the world this tooling has been deployed as well the benefits the tooling has provided. (author)

  9. Research tools | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Through training materials and guides, we aim to build skills and knowledge to enhance the quality of development research. We also offer free access to our database of funded research projects, known as IDRIS+, and our digital library. Our research tools include. Guide to research databases at IDRC: How to access and ...

  10. Latest Developments in PVD Coatings for Tooling

    Directory of Open Access Journals (Sweden)

    Gabriela Strnad

    2010-06-01

    Full Text Available The paper presents the recent developments in the field of PVD coating for manufacturing tools. A review of monoblock, multilayer, nanocomposite, DLC and oxinitride coatings is discussed, with the emphasis on coatings which enables the manufacturers to implement high productivity processes such as high speed cutting and dry speed machining.

  11. Online Analytical Processing (OLAP: A Fast and Effective Data Mining Tool for Gene Expression Databases

    Directory of Open Access Journals (Sweden)

    Alkharouf Nadim W.

    2005-01-01

    Full Text Available Gene expression databases contain a wealth of information, but current data mining tools are limited in their speed and effectiveness in extracting meaningful biological knowledge from them. Online analytical processing (OLAP can be used as a supplement to cluster analysis for fast and effective data mining of gene expression databases. We used Analysis Services 2000, a product that ships with SQLServer2000, to construct an OLAP cube that was used to mine a time series experiment designed to identify genes associated with resistance of soybean to the soybean cyst nematode, a devastating pest of soybean. The data for these experiments is stored in the soybean genomics and microarray database (SGMD. A number of candidate resistance genes and pathways were found. Compared to traditional cluster analysis of gene expression data, OLAP was more effective and faster in finding biologically meaningful information. OLAP is available from a number of vendors and can work with any relational database management system through OLE DB.

  12. Online analytical processing (OLAP): a fast and effective data mining tool for gene expression databases.

    Science.gov (United States)

    Alkharouf, Nadim W; Jamison, D Curtis; Matthews, Benjamin F

    2005-06-30

    Gene expression databases contain a wealth of information, but current data mining tools are limited in their speed and effectiveness in extracting meaningful biological knowledge from them. Online analytical processing (OLAP) can be used as a supplement to cluster analysis for fast and effective data mining of gene expression databases. We used Analysis Services 2000, a product that ships with SQLServer2000, to construct an OLAP cube that was used to mine a time series experiment designed to identify genes associated with resistance of soybean to the soybean cyst nematode, a devastating pest of soybean. The data for these experiments is stored in the soybean genomics and microarray database (SGMD). A number of candidate resistance genes and pathways were found. Compared to traditional cluster analysis of gene expression data, OLAP was more effective and faster in finding biologically meaningful information. OLAP is available from a number of vendors and can work with any relational database management system through OLE DB.

  13. Development and validation of analytical methods for dietary supplements

    International Nuclear Information System (INIS)

    Sullivan, Darryl; Crowley, Richard

    2006-01-01

    The expanding use of innovative botanical ingredients in dietary supplements and foods has resulted in a flurry of research aimed at the development and validation of analytical methods for accurate measurement of active ingredients. The pressing need for these methods is being met through an expansive collaborative initiative involving industry, government, and analytical organizations. This effort has resulted in the validation of several important assays as well as important advances in the method engineering procedures which have improved the efficiency of the process. The initiative has also allowed researchers to hurdle many of the barricades that have hindered accurate analysis such as the lack of reference standards and comparative data. As the availability for nutraceutical products continues to increase these methods will provide consumers and regulators with the scientific information needed to assure safety and dependable labeling

  14. Development of computerized risk management tool

    International Nuclear Information System (INIS)

    Kil Yoo Kim; Mee Jung Hwang; Seung Cheol Jang; Sang Hoon Han; Tae Woon Kim

    1997-01-01

    The author describes the kinds of efforts for the development of computerized risk management tool; (1) development of a risk monitor, Risk Monster, (2) improvement of McFarm (Missing Cutsets Finding Algorithm for Risk Monitor) and finally (3) development of reliability database management system, KwDBMan. Risk Monster supports for plant operators and maintenance schedulers to monitor plant risk and to avoid high peak risk by rearranging maintenance work schedule. Improved McFarm significantly improved calculation speed of Risk Monster for the cases of supporting system OOS (Out Of Service). KwDBMan manages event data, generic data and CCF (Common Cause Failure) data to support Risk Monster as well as PSA tool, KIRAP (KAERI Integrated Reliability Analysis Package)

  15. Software development tools using GPGPU potentialities

    International Nuclear Information System (INIS)

    Dudnik, V.A.; Kudryavtsev, V.I.; Sereda, T.M.; Us, S.A.; Shestakov, M.V.

    2011-01-01

    The paper deals with potentialities of various up-to-date software development tools for making use of graphic processor (GPU) parallel computing resources. Examples are given to illustrate the use of present-day software tools for the development of applications and realization of algorithms for scientific-technical calculations performed by GPGPU. The paper presents some classes of hard mathematical problems of scientific-technical calculations, for which the GPGPU can be efficiently used. is possible. To reduce the time of calculation program development with the use of GPGPU capabilities, various dedicated programming systems and problem-oriented subroutine libraries are recommended. Performance parameters when solving the problems with and without the use of GPGPU potentialities are compared.

  16. Development of bore tools for pipe inspection

    Energy Technology Data Exchange (ETDEWEB)

    Oka, Kiyoshi; Nakahira, Masataka; Taguchi, Kou; Ito, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-04-01

    In the International Thermonuclear Reactor (ITER), replacement and maintenance on in-vessel components requires that all cooling pipes connected be cut and removed, that a new component be installed, and that all cooling pipes be rewelded. After welding is completed, welded area must be inspected for soundness. These tasks require a new work concept for securing shielded area and access from narrow ports. Tools had to be developed for nondestructive inspection and leak testing to evaluate pipe welding soundness by accessing areas from inside pipes using autonomous locomotion welding and cutting tools. A system was proposed for nondestructive inspection of branch pipes and the main pipe after passing through pipe curves, the same as for welding and cutting tool development. Nondestructive inspection and leak testing sensors were developed and the basic parameters were obtained. In addition, the inspection systems which can move inside pipes and conduct the nondestructive inspection and the leak testing were developed. In this paper, an introduction will be given to the current situation concerning the development of nondestructive inspection and leak testing machines for the branch pipes. (author)

  17. Developing automated analytical methods for scientific environments using LabVIEW.

    Science.gov (United States)

    Wagner, Christoph; Armenta, Sergio; Lendl, Bernhard

    2010-01-15

    The development of new analytical techniques often requires the building of specially designed devices, each requiring its own dedicated control software. Especially in the research and development phase, LabVIEW has proven to be one highly useful tool for developing this software. Yet, it is still common practice to develop individual solutions for different instruments. In contrast to this, we present here a single LabVIEW-based program that can be directly applied to various analytical tasks without having to change the program code. Driven by a set of simple script commands, it can control a whole range of instruments, from valves and pumps to full-scale spectrometers. Fluid sample (pre-)treatment and separation procedures can thus be flexibly coupled to a wide range of analytical detection methods. Here, the capabilities of the program have been demonstrated by using it for the control of both a sequential injection analysis - capillary electrophoresis (SIA-CE) system with UV detection, and an analytical setup for studying the inhibition of enzymatic reactions using a SIA system with FTIR detection.

  18. Stable isotope ratio analysis: A potential analytical tool for the authentication of South African lamb meat.

    Science.gov (United States)

    Erasmus, Sara Wilhelmina; Muller, Magdalena; van der Rijst, Marieta; Hoffman, Louwrens Christiaan

    2016-02-01

    Stable isotope ratios ((13)C/(12)C and (15)N/(14)N) of South African Dorper lambs from farms with different vegetation types were measured by isotope ratio mass spectrometry (IRMS), to evaluate it as a tool for the authentication of origin and feeding regime. Homogenised and defatted meat of the Longissimus lumborum (LL) muscle of lambs from seven different farms was assessed. The δ(13)C values were affected by the origin of the meat, mainly reflecting the diet. The Rûens and Free State farms had the lowest (p ⩽ 0.05) δ(15)N values, followed by the Northern Cape farms, with Hantam Karoo/Calvinia having the highest δ(15)N values. Discriminant analysis showed δ(13)C and δ(15)N differences as promising results for the use of IRMS as a reliable analytical tool for lamb meat authentication. The results suggest that diet, linked to origin, is an important factor to consider regarding region of origin classification for South African lamb. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Comparison of the most used game development tools

    OpenAIRE

    Soukup, Martin

    2017-01-01

    This thesis deals with comparison of most used game development tools. Author places game development tools in context of today´s game industry, analyses state of the market and the latest trends in the field of game development tools. The largest part of this thesis is aimed at comparing game development tools, where five tools are selected, overviewed and compared by specified criteria. Author demonstrates several basic features of chosen game development tool on development of a simple And...

  20. 100-B/C Target Analyte List Development for Soil

    Energy Technology Data Exchange (ETDEWEB)

    R.W. Ovink

    2010-03-18

    This report documents the process used to identify source area target analytes in support of the 100-B/C remedial investigation/feasibility study addendum to DOE/RL-2008-46. This report also establishes the analyte exclusion criteria applicable for 100-B/C use and the analytical methods needed to analyze the target analytes.

  1. Development of special analytical system for determination of free acid

    International Nuclear Information System (INIS)

    Zhang Lihua; Wu Jizong; Liu Huanliang; Liu Quanwei; Fan Dejun; Su Tao

    2008-01-01

    The determination of free-acid plays an important role in spent fuel reprocessing analysis. Its work accounts for about 30% of all analytical work in reprocessing. It is necessary to study and develop a special fast analytical system for determination of free acid. The special analytical system is particularly applicable to determination of free acid in high-level radioactive environment, which is composed of an optical fiber spectrophotometer and an automatic sample-in device. Small sample-in volume needed, fast procedure, easy operation and physical protection are its advantages. All kinds of performance and parameters satisfy the requirements of spent fuel reprocessing control analysis. For long-distance determination, the optical fiber spectrophotometer is connected with an 4.5 meters long optical fiber. To resolve the change of 0.1 mol/L acidity, the measuring optical path is 2 cm. Mass of 10-20 μm in diameter optical fibers are assembled. The optical fiber probe is composed of a reflecting mirror and a concave mirror on the top of optical fibers. To eliminate the interference of external light, a stainless steel measuring chamber is used. The automatic sample-in device is composed of state valve, quantifying pump and pipe. The sample-in precision of 15 μl and 35 μl quantifying loops is better than 0.5%. The special analytical system takes less than 7 minutes to complete one measurement. The linear range is 0.5 mol/L-3.5 mol/L. The relative standard deviation is better than 2.0% when the concentration of the free acid is about 2.0 mol/L. For samples in different medium, the results are comparable with the method of pH titration of determining the free acid in reprocessing. (authors)

  2. Complete equation of state for shocked liquid nitrogen: Analytical developments

    International Nuclear Information System (INIS)

    Winey, J. M.; Gupta, Y. M.

    2016-01-01

    The thermodynamic response of liquid nitrogen has been studied extensively, in part, due to the long-standing interest in the high pressure and high temperature dissociation of shocked molecular nitrogen. Previous equation of state (EOS) developments regarding shocked liquid nitrogen have focused mainly on the use of intermolecular pair potentials in atomistic calculations. Here, we present EOS developments for liquid nitrogen, incorporating analytical models, for use in continuum calculations of the shock compression response. The analytical models, together with available Hugoniot data, were used to extrapolate a low pressure reference EOS for molecular nitrogen [Span, et al., J. Phys. Chem. Ref. Data 29, 1361 (2000)] to high pressures and high temperatures. Using the EOS presented here, the calculated pressures and temperatures for single shock, double shock, and multiple shock compression of liquid nitrogen provide a good match to the measured results over a broad range of P-T space. Our calculations provide the first comparison of EOS developments with recently-measured P-T states under multiple shock compression. The present EOS developments are general and are expected to be useful for other liquids that have low pressure reference EOS information available.

  3. ProteoLens: a visual analytic tool for multi-scale database-driven biological network data mining.

    Science.gov (United States)

    Huan, Tianxiao; Sivachenko, Andrey Y; Harrison, Scott H; Chen, Jake Y

    2008-08-12

    New systems biology studies require researchers to understand how interplay among myriads of biomolecular entities is orchestrated in order to achieve high-level cellular and physiological functions. Many software tools have been developed in the past decade to help researchers visually navigate large networks of biomolecular interactions with built-in template-based query capabilities. To further advance researchers' ability to interrogate global physiological states of cells through multi-scale visual network explorations, new visualization software tools still need to be developed to empower the analysis. A robust visual data analysis platform driven by database management systems to perform bi-directional data processing-to-visualizations with declarative querying capabilities is needed. We developed ProteoLens as a JAVA-based visual analytic software tool for creating, annotating and exploring multi-scale biological networks. It supports direct database connectivity to either Oracle or PostgreSQL database tables/views, on which SQL statements using both Data Definition Languages (DDL) and Data Manipulation languages (DML) may be specified. The robust query languages embedded directly within the visualization software help users to bring their network data into a visualization context for annotation and exploration. ProteoLens supports graph/network represented data in standard Graph Modeling Language (GML) formats, and this enables interoperation with a wide range of other visual layout tools. The architectural design of ProteoLens enables the de-coupling of complex network data visualization tasks into two distinct phases: 1) creating network data association rules, which are mapping rules between network node IDs or edge IDs and data attributes such as functional annotations, expression levels, scores, synonyms, descriptions etc; 2) applying network data association rules to build the network and perform the visual annotation of graph nodes and edges

  4. Selecting Tools for Renewable Energy Analysis in Developing Countries: An Expanded Review

    Energy Technology Data Exchange (ETDEWEB)

    Irsyad, M. Indra al [School of Earth and Environmental Science, University of Queensland, Brisbane, QLD (Australia); Ministry of Energy and Mineral Resources, Jakarta (Indonesia); Halog, Anthony Basco, E-mail: a.halog@uq.edu.au [School of Earth and Environmental Science, University of Queensland, Brisbane, QLD (Australia); Nepal, Rabindra [Massey Business School, Massey University, Palmerston North (New Zealand); Koesrindartoto, Deddy P. [School of Business and Management, Institut Teknologi Bandung, Bandung (Indonesia)

    2017-12-20

    Renewable energy planners in developing countries should be cautious in using analytical tools formulated in developed countries. Traditional energy consumption, economic and demography transitions, high-income inequality, and informal economy are some characteristics of developing countries that may contradict the assumptions of mainstream, widely used analytical tools. In this study, we synthesize the debate in previous review studies on energy models for developing countries and then extend the scope of the previous studies by highlighting emerging methods of system thinking, life cycle thinking, and decision support analysis. We then discuss how these tools have been used for renewable energy analysis in developing countries and found out that not all studies are aware of the emerging critical issues in developing countries. We offer here a guidance to select the most appropriate analytical tool, mainly when dealing with energy modeling and analysis for developing countries. We also suggest potential future improvements to the analytical tool for renewable energy modeling and analysis in the developing countries.

  5. Selecting Tools for Renewable Energy Analysis in Developing Countries: An Expanded Review

    International Nuclear Information System (INIS)

    Irsyad, M. Indra al; Halog, Anthony Basco; Nepal, Rabindra; Koesrindartoto, Deddy P.

    2017-01-01

    Renewable energy planners in developing countries should be cautious in using analytical tools formulated in developed countries. Traditional energy consumption, economic and demography transitions, high-income inequality, and informal economy are some characteristics of developing countries that may contradict the assumptions of mainstream, widely used analytical tools. In this study, we synthesize the debate in previous review studies on energy models for developing countries and then extend the scope of the previous studies by highlighting emerging methods of system thinking, life cycle thinking, and decision support analysis. We then discuss how these tools have been used for renewable energy analysis in developing countries and found out that not all studies are aware of the emerging critical issues in developing countries. We offer here a guidance to select the most appropriate analytical tool, mainly when dealing with energy modeling and analysis for developing countries. We also suggest potential future improvements to the analytical tool for renewable energy modeling and analysis in the developing countries.

  6. Developing Expert Tools for the LHC

    CERN Document Server

    AUTHOR|(CDS)2160780; Timkó, Helga

    2017-10-12

    This Thesis describes software tools developed for automated, precision setting-up of low-power level radio frequency (LLRF) loops, which will help expert users to have better control and faster setting-up of the radio-frequency (RF) system in the Large Hadron Collider (LHC) experiment. The aim was to completely redesign the software architecture, to add new features, to improve certain algorithms, and to increase the automation.

  7. Development of configuration risk management tool

    International Nuclear Information System (INIS)

    Masuda, Takahiro; Doi, Eiji

    2003-01-01

    Tokyo Electric Power Company (referred to as TEPCO hereinafter), and other Japanese utilities as well, have been trying to improve the capacity factor of their Nuclear Power Plants (NPPs) through modernization of Operation and Maintenance strategy. TEPCO intends to apply risk information to O and M field with maintaining or even improving both safety and production efficiency. Under these situations, TEPCO with some BWR utilities started to develop a Configuration Risk Management (CRM) tool that can estimate risk in various plant conditions due to configuration changes during outage. Moreover, we also intend to apply CRM to on-line maintenance (OLM) in the near future. This tool can calculate the Core Damage Frequency (CDF) according to given plant condition, such as SSCs availability, decay heat level and the inventory of coolant in both outage state and full-power operation. From deterministic viewpoint, whether certain configuration meet the related requirements of Technical Specifications. User-friendly interface is one of the important features of this tool because this enables the site engineers with little experience in PSA to quantify and utilize the risk information by this tool. (author)

  8. Web Analytics

    Science.gov (United States)

    EPA’s Web Analytics Program collects, analyzes, and provides reports on traffic, quality assurance, and customer satisfaction metrics for EPA’s website. The program uses a variety of analytics tools, including Google Analytics and CrazyEgg.

  9. Surrogate Analysis and Index Developer (SAID) tool

    Science.gov (United States)

    Domanski, Marian M.; Straub, Timothy D.; Landers, Mark N.

    2015-10-01

    The use of acoustic and other parameters as surrogates for suspended-sediment concentrations (SSC) in rivers has been successful in multiple applications across the Nation. Tools to process and evaluate the data are critical to advancing the operational use of surrogates along with the subsequent development of regression models from which real-time sediment concentrations can be made available to the public. Recent developments in both areas are having an immediate impact on surrogate research and on surrogate monitoring sites currently (2015) in operation.

  10. Electrochemical immunoassay using magnetic beads for the determination of zearalenone in baby food: An anticipated analytical tool for food safety

    International Nuclear Information System (INIS)

    Hervas, Miriam; Lopez, Miguel Angel; Escarpa, Alberto

    2009-01-01

    In this work, electrochemical immunoassay involving magnetic beads to determine zearalenone in selected food samples has been developed. The immunoassay scheme has been based on a direct competitive immunoassay method in which antibody-coated magnetic beads were employed as the immobilisation support and horseradish peroxidase (HRP) was used as enzymatic label. Amperometric detection has been achieved through the addition of hydrogen peroxide substrate and hydroquinone as mediator. Analytical performance of the electrochemical immunoassay has been evaluated by analysis of maize certified reference material (CRM) and selected baby food samples. A detection limit (LOD) of 0.011 μg L -1 and EC 50 0.079 μg L -1 were obtained allowing the assessment of the detection of zearalenone mycotoxin. In addition, an excellent accuracy with a high recovery yield ranging between 95 and 108% has been obtained. The analytical features have shown the proposed electrochemical immunoassay to be a very powerful and timely screening tool for the food safety scene.

  11. Electrochemical immunoassay using magnetic beads for the determination of zearalenone in baby food: An anticipated analytical tool for food safety

    Energy Technology Data Exchange (ETDEWEB)

    Hervas, Miriam; Lopez, Miguel Angel [Departamento Quimica Analitica, Universidad de Alcala, Ctra. Madrid-Barcelona, Km. 33600, E-28871 Alcala de Henares, Madrid (Spain); Escarpa, Alberto, E-mail: alberto.escarpa@uah.es [Departamento Quimica Analitica, Universidad de Alcala, Ctra. Madrid-Barcelona, Km. 33600, E-28871 Alcala de Henares, Madrid (Spain)

    2009-10-27

    In this work, electrochemical immunoassay involving magnetic beads to determine zearalenone in selected food samples has been developed. The immunoassay scheme has been based on a direct competitive immunoassay method in which antibody-coated magnetic beads were employed as the immobilisation support and horseradish peroxidase (HRP) was used as enzymatic label. Amperometric detection has been achieved through the addition of hydrogen peroxide substrate and hydroquinone as mediator. Analytical performance of the electrochemical immunoassay has been evaluated by analysis of maize certified reference material (CRM) and selected baby food samples. A detection limit (LOD) of 0.011 {mu}g L{sup -1} and EC{sub 50} 0.079 {mu}g L{sup -1} were obtained allowing the assessment of the detection of zearalenone mycotoxin. In addition, an excellent accuracy with a high recovery yield ranging between 95 and 108% has been obtained. The analytical features have shown the proposed electrochemical immunoassay to be a very powerful and timely screening tool for the food safety scene.

  12. Fernald Silo Remote Retrieval Tool Development

    International Nuclear Information System (INIS)

    Varma, V.K.

    2004-01-01

    A long-reach tool was developed to remove discrete objects from the silos at the Fernald Environmental Management Project in Ohio. If they are not removed, these objects can potentially cause problems during the retrieval and transfer of waste from the silos. Most of the objects are on top of the Bentogrout cap inside the silos at or near the primary opening into the tank and will therefore require only vertical lifting. The objects are located about 20 ft from the top of the silo. Although most of the objects can be retrieved from 20 ft, the long-reach tool was designed to for a reach up to 40 ft in case objects roll towards the walls of the tank or need to be removed during heel retrieval operations. This report provides a detailed description of the tool that was developed, tested, and demonstrated at the Tanks Technology Cold Test Facility at Oak Ridge National Laboratory. Scaffolding was erected over two experimental cells to simulate the 40-ft maximum working depth anticipated in the silos at Fernald. Plastic bottles and plastic sheeting simulated the debris that could be encountered during waste retrieval operations

  13. Target normal sheath acceleration analytical modeling, comparative study and developments

    International Nuclear Information System (INIS)

    Perego, C.; Batani, D.; Zani, A.; Passoni, M.

    2012-01-01

    Ultra-intense laser interaction with solid targets appears to be an extremely promising technique to accelerate ions up to several MeV, producing beams that exhibit interesting properties for many foreseen applications. Nowadays, most of all the published experimental results can be theoretically explained in the framework of the target normal sheath acceleration (TNSA) mechanism proposed by Wilks et al. [Phys. Plasmas 8(2), 542 (2001)]. As an alternative to numerical simulation various analytical or semi-analytical TNSA models have been published in the latest years, each of them trying to provide predictions for some of the ion beam features, given the initial laser and target parameters. However, the problem of developing a reliable model for the TNSA process is still open, which is why the purpose of this work is to enlighten the present situation of TNSA modeling and experimental results, by means of a quantitative comparison between measurements and theoretical predictions of the maximum ion energy. Moreover, in the light of such an analysis, some indications for the future development of the model proposed by Passoni and Lontano [Phys. Plasmas 13(4), 042102 (2006)] are then presented.

  14. Process-Based Quality (PBQ) Tools Development

    Energy Technology Data Exchange (ETDEWEB)

    Cummins, J.L.

    2001-12-03

    The objective of this effort is to benchmark the development of process-based quality tools for application in CAD (computer-aided design) model-based applications. The processes of interest are design, manufacturing, and quality process applications. A study was commissioned addressing the impact, current technologies, and known problem areas in application of 3D MCAD (3-dimensional mechanical computer-aided design) models and model integrity on downstream manufacturing and quality processes. The downstream manufacturing and product quality processes are profoundly influenced and dependent on model quality and modeling process integrity. The goal is to illustrate and expedite the modeling and downstream model-based technologies for available or conceptual methods and tools to achieve maximum economic advantage and advance process-based quality concepts.

  15. LitPathExplorer: a confidence-based visual text analytics tool for exploring literature-enriched pathway models.

    Science.gov (United States)

    Soto, Axel J; Zerva, Chrysoula; Batista-Navarro, Riza; Ananiadou, Sophia

    2018-04-15

    Pathway models are valuable resources that help us understand the various mechanisms underpinning complex biological processes. Their curation is typically carried out through manual inspection of published scientific literature to find information relevant to a model, which is a laborious and knowledge-intensive task. Furthermore, models curated manually cannot be easily updated and maintained with new evidence extracted from the literature without automated support. We have developed LitPathExplorer, a visual text analytics tool that integrates advanced text mining, semi-supervised learning and interactive visualization, to facilitate the exploration and analysis of pathway models using statements (i.e. events) extracted automatically from the literature and organized according to levels of confidence. LitPathExplorer supports pathway modellers and curators alike by: (i) extracting events from the literature that corroborate existing models with evidence; (ii) discovering new events which can update models; and (iii) providing a confidence value for each event that is automatically computed based on linguistic features and article metadata. Our evaluation of event extraction showed a precision of 89% and a recall of 71%. Evaluation of our confidence measure, when used for ranking sampled events, showed an average precision ranging between 61 and 73%, which can be improved to 95% when the user is involved in the semi-supervised learning process. Qualitative evaluation using pair analytics based on the feedback of three domain experts confirmed the utility of our tool within the context of pathway model exploration. LitPathExplorer is available at http://nactem.ac.uk/LitPathExplorer_BI/. sophia.ananiadou@manchester.ac.uk. Supplementary data are available at Bioinformatics online.

  16. A Tool for Conceptualising in PSS development

    DEFF Research Database (Denmark)

    Matzen, Detlef; McAloone, Timothy Charles

    2006-01-01

    This paper introduces a tool for conceptualising in the development of product/servicesystems (PSS), based upon the modelling of service activities. Our argumentation is built on two previous articles by the same author, previously presented at the 16. Symposium “Design for X” [1] and the 9th Int...... the integrated consideration of the customers’ activities, possible PSS offerings and beneficial partnering options (i.e. between different supplier companies) within the delivery value chain.......This paper introduces a tool for conceptualising in the development of product/servicesystems (PSS), based upon the modelling of service activities. Our argumentation is built on two previous articles by the same author, previously presented at the 16. Symposium “Design for X” [1] and the 9th...... International Design Conference [2]. In this contribution, we take the step from a fundamental understanding of the phenomenon to creating a normative exploitation of this understanding for PSS concept development. The developed modelling technique is based on the Customer Activity Cycle (CAC) model...

  17. Developing an Emergency Physician Productivity Index Using Descriptive Health Analytics.

    Science.gov (United States)

    Khalifa, Mohamed

    2015-01-01

    Emergency department (ED) crowding became a major barrier to receiving timely emergency care. At King Faisal Specialist Hospital and Research Center, Saudi Arabia, we identified variables and factors affecting crowding and performance to develop indicators to help evaluation and improvement. Measuring efficiency of work and activity of throughput processes; it was important to develop an ED physician productivity index. Data on all ED patients' encounters over the last six months of 2014 were retrieved and descriptive health analytics methods were used. Three variables were identified for their influence on productivity and performance; Number of Treated Patients per Physician, Patient Acuity Level and Treatment Time. The study suggested a formula to calculate the productivity index of each physician through dividing the Number of Treated Patients by Patient Acuity Level squared and Treatment Time to identify physicians with low productivity index and investigate causes and factors.

  18. USING ANALYTIC HIERARCHY PROCESS (AHP METHOD IN RURAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Tülay Cengiz

    2003-04-01

    Full Text Available Rural development is a body of economical and social policies towards improving living conditions in rural areas through enabling rural population to utilize economical, social, cultural and technological blessing of city life in place, without migrating. As it is understood from this description, rural development is a very broad concept. Therefore, in development efforts problem should be stated clearly, analyzed and many criterias should be evaluated by experts. Analytic Hierarchy Process (AHP method can be utilized at there stages of development efforts. AHP methods is one of multi-criteria decision method. After degrading a problem in smaller pieces, relative importance and level of importance of two compared elements are determined. It allows evaluation of quality and quantity factors. At the same time, it permits utilization of ideas of many experts and use them in decision process. Because mentioned features of AHP method, it could be used in rural development works. In this article, cultural factors, one of the important components of rural development is often ignored in many studies, were evaluated as an example. As a result of these applications and evaluations, it is concluded that AHP method could be helpful in rural development efforts.

  19. Raman-in-SEM, a multimodal and multiscale analytical tool: performance for materials and expertise.

    Science.gov (United States)

    Wille, Guillaume; Bourrat, Xavier; Maubec, Nicolas; Lahfid, Abdeltif

    2014-12-01

    The availability of Raman spectroscopy in a powerful analytical scanning electron microscope (SEM) allows morphological, elemental, chemical, physical and electronic analysis without moving the sample between instruments. This paper documents the metrological performance of the SEMSCA commercial Raman interface operated in a low vacuum SEM. It provides multiscale and multimodal analyses as Raman/EDS, Raman/cathodoluminescence or Raman/STEM (STEM: scanning transmission electron microscopy) as well as Raman spectroscopy on nanomaterials. Since Raman spectroscopy in a SEM can be influenced by several SEM-related phenomena, this paper firstly presents a comparison of this new tool with a conventional micro-Raman spectrometer. Then, some possible artefacts are documented, which are due to the impact of electron beam-induced contamination or cathodoluminescence contribution to the Raman spectra, especially with geological samples. These effects are easily overcome by changing or adapting the Raman spectrometer and the SEM settings and methodology. The deletion of the adverse effect of cathodoluminescence is solved by using a SEM beam shutter during Raman acquisition. In contrast, this interface provides the ability to record the cathodoluminescence (CL) spectrum of a phase. In a second part, this study highlights the interest and efficiency of the coupling in characterizing micrometric phases at the same point. This multimodal approach is illustrated with various issues encountered in geosciences. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Room temperature phosphorescence in the liquid state as a tool in analytical chemistry

    International Nuclear Information System (INIS)

    Kuijt, Jacobus; Ariese, Freek; Brinkman, Udo A.Th.; Gooijer, Cees

    2003-01-01

    A wide-ranging overview of room temperature phosphorescence in the liquid state (RTPL ) is presented, with a focus on recent developments. RTPL techniques like micelle-stabilized (MS)-RTP, cyclodextrin-induced (CD)-RTP, and heavy atom-induced (HAI)-RTP are discussed. These techniques are mainly applied in the stand-alone format, but coupling with some separation techniques appears to be feasible. Applications of direct, sensitized and quenched phosphorescence are also discussed. As regards sensitized and quenched RTP, emphasis is on the coupling with liquid chromatography (LC) and capillary electrophoresis (CE), but stand-alone applications are also reported. Further, the application of RTPL in immunoassays and in RTP optosensing - the optical sensing of analytes based on RTP - is reviewed. Next to the application of RTPL in quantitative analysis, its use for the structural probing of protein conformations and for time-resolved microscopy of labelled biomolecules is discussed. Finally, an overview is presented of the various analytical techniques which are based on the closely related phenomenon of long-lived lanthanide luminescence. The paper closes with a short evaluation of the state-of-the-art in RTP and a discussion on future perspectives

  1. Developing a mapping tool for tablets

    Science.gov (United States)

    Vaughan, Alan; Collins, Nathan; Krus, Mike

    2014-05-01

    Digital field mapping offers significant benefits when compared with traditional paper mapping techniques in that it provides closer integration with downstream geological modelling and analysis. It also provides the mapper with the ability to rapidly integrate new data with existing databases without the potential degradation caused by repeated manual transcription of numeric, graphical and meta-data. In order to achieve these benefits, a number of PC-based digital mapping tools are available which have been developed for specific communities, eg the BGS•SIGMA project, Midland Valley's FieldMove®, and a range of solutions based on ArcGIS® software, which can be combined with either traditional or digital orientation and data collection tools. However, with the now widespread availability of inexpensive tablets and smart phones, a user led demand for a fully integrated tablet mapping tool has arisen. This poster describes the development of a tablet-based mapping environment specifically designed for geologists. The challenge was to deliver a system that would feel sufficiently close to the flexibility of paper-based geological mapping while being implemented on a consumer communication and entertainment device. The first release of a tablet-based geological mapping system from this project is illustrated and will be shown as implemented on an iPad during the poster session. Midland Valley is pioneering tablet-based mapping and, along with its industrial and academic partners, will be using the application in field based projects throughout this year and will be integrating feedback in further developments of this technology.

  2. Preparation of standard hair material and development of analytical methodology

    International Nuclear Information System (INIS)

    Gangadharan, S.; Ganapathi Iyer, S.; Ali, M.M.; Thantry, S.S.; Verma, R.; Arunachalam, J.; Walvekar, A.P.

    1992-01-01

    In 1976 Indian Researchers suggested the possible use of hair as an indicator of environmental exposure and established through a study of country wide student population and general population of the metropolitan city of Bombay that human scalp hair could indeed be an effective first level monitor in a scheme of multilevel monitoring of environmental exposure to inorganic pollutants. It was in this context and in view of the ready availability of large quantities of scalp hair subjected to minimum treatment by chemicals that they proposed to participate in the preparation of a standard material of hair. It was also recognized that measurements of trace element concentrations at very low levels require cross-validation by different analytical techniques, even within the same laboratory. The programme of work that has been carried out since the first meeting of the CRP had been aimed at these two objectives. These objectives include the preparation of standard material of hair and the development of analytical methodologies for determination of elements and species of interest. 1 refs., 3 tabs

  3. Networks as Tools for Sustainable Urban Development

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole; Tollin, Nicola

    will be discussed through a case study of a Danish municipal network on Sustainable Development, Dogme 20001. This network has become quite successful in terms of learning and innovation, committing actors, and influencing local policies, to a larger extent than other SUD-networks the municipalities are involved in....... By applying the GREMI2-theories of “innovative milieux” (Aydalot, 1986; Camagni, 1991) to the case study, we will suggest some reasons for the benefits achieved by the Dogme-network, compared to other networks. This analysis will point to the existence of an “innovative milieu” on sustainability within......Due to the increasing number of networks related to sustainable development (SUD) the paper focuses on understanding in which way networks can be considered useful tools for sustainable urban development, taking particularly into consideration the networks potential of spreading innovative policies...

  4. Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.

    Science.gov (United States)

    Srinivas, Nuggehally R

    2006-05-01

    The development of sound bioanalytical method(s) is of paramount importance during the process of drug discovery and development culminating in a marketing approval. Although the bioanalytical procedure(s) originally developed during the discovery stage may not necessarily be fit to support the drug development scenario, they may be suitably modified and validated, as deemed necessary. Several reviews have appeared over the years describing analytical approaches including various techniques, detection systems, automation tools that are available for an effective separation, enhanced selectivity and sensitivity for quantitation of many analytes. The intention of this review is to cover various key areas where analytical method development becomes necessary during different stages of drug discovery research and development process. The key areas covered in this article with relevant case studies include: (a) simultaneous assay for parent compound and metabolites that are purported to display pharmacological activity; (b) bioanalytical procedures for determination of multiple drugs in combating a disease; (c) analytical measurement of chirality aspects in the pharmacokinetics, metabolism and biotransformation investigations; (d) drug monitoring for therapeutic benefits and/or occupational hazard; (e) analysis of drugs from complex and/or less frequently used matrices; (f) analytical determination during in vitro experiments (metabolism and permeability related) and in situ intestinal perfusion experiments; (g) determination of a major metabolite as a surrogate for the parent molecule; (h) analytical approaches for universal determination of CYP450 probe substrates and metabolites; (i) analytical applicability to prodrug evaluations-simultaneous determination of prodrug, parent and metabolites; (j) quantitative determination of parent compound and/or phase II metabolite(s) via direct or indirect approaches; (k) applicability in analysis of multiple compounds in select

  5. saltPAD: A New Analytical Tool for Monitoring Salt Iodization in Low Resource Settings

    Directory of Open Access Journals (Sweden)

    Nicholas M. Myers

    2016-03-01

    Full Text Available We created a paper test card that measures a common iodizing agent, iodate, in salt. To test the analytical metrics, usability, and robustness of the paper test card when it is used in low resource settings, the South African Medical Research Council and GroundWork performed independ‐ ent validation studies of the device. The accuracy and precision metrics from both studies were comparable. In the SAMRC study, more than 90% of the test results (n=1704 were correctly classified as corresponding to adequately or inadequately iodized salt. The cards are suitable for market and household surveys to determine whether salt is adequately iodized. Further development of the cards will improve their utility for monitoring salt iodization during production.

  6. An analytic framework for developing inherently-manufacturable pop-up laminate devices

    International Nuclear Information System (INIS)

    Aukes, Daniel M; Goldberg, Benjamin; Wood, Robert J; Cutkosky, Mark R

    2014-01-01

    Spurred by advances in manufacturing technologies developed around layered manufacturing technologies such as PC-MEMS, SCM, and printable robotics, we propose a new analytic framework for capturing the geometry of folded composite laminate devices and the mechanical processes used to manufacture them. These processes can be represented by combining a small set of geometric operations which are general enough to encompass many different manufacturing paradigms. Furthermore, such a formulation permits one to construct a variety of geometric tools which can be used to analyze common manufacturability concepts, such as tool access, part removability, and device support. In order to increase the speed of development, reduce the occurrence of manufacturing problems inherent with current design methods, and reduce the level of expertise required to develop new devices, the framework has been implemented in a new design tool called popupCAD, which is suited for the design and development of complex folded laminate devices. We conclude with a demonstration of utility of the tools by creating a folded leg mechanism. (paper)

  7. Accept or Decline? An Analytics-Based Decision Tool for Kidney Offer Evaluation.

    Science.gov (United States)

    Bertsimas, Dimitris; Kung, Jerry; Trichakis, Nikolaos; Wojciechowski, David; Vagefi, Parsia A

    2017-12-01

    When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for future higher-quality offers. However, the current experience-based paradigm lacks scientific rigor and is subject to the inaccuracies that plague anecdotal decision-making. A data-driven analytics-based model was developed to predict whether a patient will receive an offer for a deceased-donor kidney at Kidney Donor Profile Index thresholds of 0.2, 0.4, and 0.6, and at timeframes of 3, 6, and 12 months. The model accounted for Organ Procurement Organization, blood group, wait time, DR antigens, and prior offer history to provide accurate and personalized predictions. Performance was evaluated on data sets spanning various lengths of time to understand the adaptability of the method. Using United Network for Organ Sharing match-run data from March 2007 to June 2013, out-of-sample area under the receiver operating characteristic curve was approximately 0.87 for all Kidney Donor Profile Index thresholds and timeframes considered for the 10 most populous Organ Procurement Organizations. As more data becomes available, area under the receiver operating characteristic curve values increase and subsequently level off. The development of a data-driven analytics-based model may assist transplant practitioners and candidates during the complex decision of whether to accept or forgo a current kidney offer in anticipation of a future high-quality offer. The latter holds promise to facilitate timely transplantation and optimize the efficiency of allocation.

  8. Life cycle assessment as an analytical tool in strategic environmental assessment. Lessons learned from a case study on municipal energy planning in Sweden

    International Nuclear Information System (INIS)

    Björklund, Anna

    2012-01-01

    Life cycle assessment (LCA) is explored as an analytical tool in strategic environmental assessment (SEA), illustrated by case where a previously developed SEA process was applied to municipal energy planning in Sweden. The process integrated decision-making tools for scenario planning, public participation and environmental assessment. This article describes the use of LCA for environmental assessment in this context, with focus on methodology and practical experiences. While LCA provides a systematic framework for the environmental assessment and a wider systems perspective than what is required in SEA, LCA cannot address all aspects of environmental impact required, and therefore needs to be complemented by other tools. The integration of LCA with tools for public participation and scenario planning posed certain methodological challenges, but provided an innovative approach to designing the scope of the environmental assessment and defining and assessing alternatives. - Research highlights: ► LCA was explored as analytical tool in an SEA process of municipal energy planning. ► The process also integrated LCA with scenario planning and public participation. ► Benefits of using LCA were a systematic framework and wider systems perspective. ► Integration of tools required some methodological challenges to be solved. ► This proved an innovative approach to define alternatives and scope of assessment.

  9. Chemometrics in analytical chemistry-part I: history, experimental design and data analysis tools.

    Science.gov (United States)

    Brereton, Richard G; Jansen, Jeroen; Lopes, João; Marini, Federico; Pomerantsev, Alexey; Rodionova, Oxana; Roger, Jean Michel; Walczak, Beata; Tauler, Romà

    2017-10-01

    Chemometrics has achieved major recognition and progress in the analytical chemistry field. In the first part of this tutorial, major achievements and contributions of chemometrics to some of the more important stages of the analytical process, like experimental design, sampling, and data analysis (including data pretreatment and fusion), are summarised. The tutorial is intended to give a general updated overview of the chemometrics field to further contribute to its dissemination and promotion in analytical chemistry.

  10. Some key issues in the development of ergonomic intervention tools

    DEFF Research Database (Denmark)

    Edwards, Kasper; Winkel, Jørgen

    2016-01-01

    Literature reviews suggest that tools facilitating the ergonomic intervention processes should be integrated into rationalization tools, particular if such tools are participative. Such a Tool has recently been developed as an add-in module to the Lean tool “Value Stream Mapping” (VSM). However...

  11. Implementing analytics a blueprint for design, development, and adoption

    CERN Document Server

    Sheikh, Nauman

    2013-01-01

    Implementing Analytics demystifies the concept, technology and application of analytics and breaks its implementation down to repeatable and manageable steps, making it possible for widespread adoption across all functions of an organization. Implementing Analytics simplifies and helps democratize a very specialized discipline to foster business efficiency and innovation without investing in multi-million dollar technology and manpower. A technology agnostic methodology that breaks down complex tasks like model design and tuning and emphasizes business decisions rather than the technology behi

  12. Developing neutronics calculation tools for MYRRHA

    International Nuclear Information System (INIS)

    Van den Eynde, G.

    2006-01-01

    The design of the Accelerator Driven System MYRRHA requires adequate and specialised tools in the field of neutronics calculations. In order to fill the gaps, several PhD programmes were launched. In 2005 three such PhD projects were running. Each of them focuses on different stages in the computation of a core of MYRRHA. The first project I mprovements of the spallation reaction model , a collaboration with the University of Liege, deals with the characterisation of the spallation neutron source using the INCL (Intra-Nuclear Cascade of Liege) model. Since at high energies, nuclear data are sparse, calculations rely on models. Especially for spallation reactions that occur at proton energies of several hundreds of MeV, models are the only means to evaluate the spallation source in MYRRHA. The second project 'Neutron transport with anisotropic scattering', a collaboration with the Universite Libre de Bruxelles, works on the development of a neutronics code, CASE-BSM, for systems with highly anisotropic scattering. The presence in large amounts of both lead and bismuth atoms in the MYRRHA core results in a highly anisotropic scattering of the neutrons in the bulk of the coolant. Neglecting this effect has large consequences on both global parameters, like keff, as well as on local parameters, like the neutron flux seen by the vessel. The third project, 'ALEPH: An integrated Monte Carlo bun-up tool', a collaboration with Ghent University, treats the last phase of a core calculation: the depletion of the fuel during irradiation. For an experimental machine like MYRRHA it is of utmost importance to have a fast calculational tool to evaluate the incineration of both isotopes present in the fuel as isotopes present in experimental devices. The main objective is to improve the current quality of the neutronics codes focused on ADS applications and to have this knowledge 'in-house'

  13. Development and first application of an operating events ranking tool

    International Nuclear Information System (INIS)

    Šimić, Zdenko; Zerger, Benoit; Banov, Reni

    2015-01-01

    Highlights: • A method using analitycal hierarchy process for ranking operating events is developed and tested. • The method is applied for 5 years of U.S. NRC Licensee Event Reports (1453 events). • Uncertainty and sensitivity of the ranking results are evaluated. • Real events assessment shows potential of the method for operating experience feedback. - Abstract: The operating experience feedback is important for maintaining and improving safety and availability in nuclear power plants. Detailed investigation of all events is challenging since it requires excessive resources, especially in case of large event databases. This paper presents an event groups ranking method to complement the analysis of individual operating events. The basis for the method is the use of an internationally accepted events characterization scheme that allows different ways of events grouping and ranking. The ranking method itself consists of implementing the analytical hierarchy process (AHP) by means of a custom developed tool which allows events ranking based on ranking indexes pre-determined by expert judgment. Following the development phase, the tool was applied to analyze a complete set of 5 years of real nuclear power plants operating events (1453 events). The paper presents the potential of this ranking method to identify possible patterns throughout the event database and therefore to give additional insights into the events as well as to give quantitative input for the prioritization of further more detailed investigation of selected event groups

  14. Innovative analytical tools to characterize prebiotic carbohydrates of functional food interest.

    Science.gov (United States)

    Corradini, Claudio; Lantano, Claudia; Cavazza, Antonella

    2013-05-01

    Functional foods are one of the most interesting areas of research and innovation in the food industry. A functional food or functional ingredient is considered to be any food or food component that provides health benefits beyond basic nutrition. Recently, consumers have shown interest in natural bioactive compounds as functional ingredients in the diet owing to their various beneficial effects for health. Water-soluble fibers and nondigestible oligosaccharides and polysaccharides can be defined as functional food ingredients. Fructooligosaccharides (FOS) and inulin are resistant to direct metabolism by the host and reach the caecocolon, where they are used by selected groups of beneficial bacteria. Furthermore, they are able to improve physical and structural properties of food, such as hydration, oil-holding capacity, viscosity, texture, sensory characteristics, and shelf-life. This article reviews major innovative analytical developments to screen and identify FOS, inulins, and the most employed nonstarch carbohydrates added or naturally present in functional food formulations. High-performance anion-exchange chromatography with pulsed electrochemical detection (HPAEC-PED) is one of the most employed analytical techniques for the characterization of those molecules. Mass spectrometry is also of great help, in particularly matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which is able to provide extensive information regarding the molecular weight and length profiles of oligosaccharides and polysaccharides. Moreover, MALDI-TOF-MS in combination with HPAEC-PED has been shown to be of great value for the complementary information it can provide. Some other techniques, such as NMR spectroscopy, are also discussed, with relevant examples of recent applications. A number of articles have appeared in the literature in recent years regarding the analysis of inulin, FOS, and other carbohydrates of interest in the field and

  15. Development of analytical techniques for water and environmental samples (2)

    Energy Technology Data Exchange (ETDEWEB)

    Eum, Chul Hun; Jeon, Chi Wan; Jung, Kang Sup; Song, Kyung Sun; Kim, Sang Yeon [Korea Institute of Geology Mining and Materials, Taejon (Korea)

    1998-12-01

    The purpose of this study is to develop new analytical methods with good detection limit for toxic inorganic and organic compounds. The analyses of CN, organic acids, particulate materials in environmental samples have been done using several methods such as Ion Chromatography, SPE, SPME, GC/MS, GC/FID, SPLITT (split-flow thin cell fractionation) during the second year of this project. Advantage and disadvantage of several distillation method (by KS, JIS, EPA) for CN analysis in wastewater were investigated. As the results, we proposed new distillation apparatus for CN analysis, which was proved to be simpler, faster and to get better recovery than conventional apparatus. And ion chromatograph/pulsed amperometric detector (IC/PAD) system instead of colorimetry for CN detection was setup to solve matrix interference. And SPE(solid phase extraction) and SPME (solid phase micro extraction) as liquid-solid extraction technique were applied to the analysis of phenols in wastewater. Optimum experimental conditions and factors influencing analytical results were determined. From these results, It could be concluded that C{sub 18} cartridge and polystyrene-divinylbenzene disk in SPE method, polyacrylate fiber in SPME were proper solid phase adsorbent for phenol. Optimum conditions to analyze phenol derivatives simultaneously were established. Also, Continuous SPLITT (Split-flow thin cell) Fractionation (CSF) is a new preparative separation technique that is useful for fractionation of particulate and macromolecular materials. CSF is carried out in a thin ribbon-like channel equipped with two splitters at both inlet and outlet of the channel. In this work, we set up a new CSF system, and tested using polystyrene latex standard particles. And then we fractionated particles contained in air and underground water based on their sedimentation coefficients using CSF. (author). 27 refs., 13 tabs., 31 figs.

  16. The Broad Application of Data Science and Analytics: Essential Tools for the Liberal Arts Graduate

    Science.gov (United States)

    Cárdenas-Navia, Isabel; Fitzgerald, Brian K.

    2015-01-01

    New technologies and data science are transforming a wide range of organizations into analytics-intensive enterprises. Despite the resulting demand for graduates with experience in the application of analytics, though, undergraduate education has been slow to change. The academic and policy communities have engaged in a decade-long conversation…

  17. Automation of analytical processes. A tool for higher efficiency and safety

    International Nuclear Information System (INIS)

    Groll, P.

    1976-01-01

    The analytical laboratory of a radiochemical facility is usually faced with the fact that numerous analyses of a similar type must be routinely carried out. Automation of such routine analytical procedures helps in increasing the efficiency and safety of the work. A review of the requirements for automation and its advantages is given and demonstrated on three examples. (author)

  18. Tools for the quantitative analysis of sedimentation boundaries detected by fluorescence optical analytical ultracentrifugation.

    Directory of Open Access Journals (Sweden)

    Huaying Zhao

    Full Text Available Fluorescence optical detection in sedimentation velocity analytical ultracentrifugation allows the study of macromolecules at nanomolar concentrations and below. This has significant promise, for example, for the study of systems of high-affinity protein interactions. Here we describe adaptations of the direct boundary modeling analysis approach implemented in the software SEDFIT that were developed to accommodate unique characteristics of the confocal fluorescence detection system. These include spatial gradients of signal intensity due to scanner movements out of the plane of rotation, temporal intensity drifts due to instability of the laser and fluorophores, and masking of the finite excitation and detection cone by the sample holder. In an extensive series of experiments with enhanced green fluorescent protein ranging from low nanomolar to low micromolar concentrations, we show that the experimental data provide sufficient information to determine the parameters required for first-order approximation of the impact of these effects on the recorded data. Systematic deviations of fluorescence optical sedimentation velocity data analyzed using conventional sedimentation models developed for absorbance and interference optics are largely removed after these adaptations, resulting in excellent fits that highlight the high precision of fluorescence sedimentation velocity data, thus allowing a more detailed quantitative interpretation of the signal boundaries that is otherwise not possible for this system.

  19. Evolutionary developments in x ray and electron energy loss microanalysis instrumentation for the analytical electron microscope

    Science.gov (United States)

    Zaluzec, Nester J.

    Developments in instrumentation for both X ray Dispersive and Electron Energy Loss Spectroscopy (XEDS/EELS) over the last ten years have given the experimentalist a greatly enhanced set of analytical tools for characterization. Microanalysts have waited for nearly two decades now in the hope of getting a true analytical microscope and the development of 300 to 400 kV instruments should have allowed us to attain this goal. Unfortunately, this has not generally been the case. While there have been some major improvements in the techniques, there has also been some devolution in the modern AEM (Analytical Electron Microscope). In XEDS, the majority of today's instruments are still plagued by the hole count effect, which was first described in detail over fifteen years ago. The magnitude of this problem can still reach the 20 percent level for medium atomic number species in a conventional off-the-shelf intermediate voltage AEM. This is an absurd situation and the manufacturers should be severely criticized. Part of the blame, however, also rests on the AEM community for not having come up with a universally agreed upon standard test procedure. Fortunately, such a test procedure is in the early stages of refinement. The proposed test specimen consists of an evaporated Cr film approx. 500 to 1000A thick supported upon a 3mm diameter Molybdenum 200 micron aperture.

  20. Using fuzzy analytical hierarchy process (AHP to evaluate web development platform

    Directory of Open Access Journals (Sweden)

    Ahmad Sarfaraz

    2012-01-01

    Full Text Available Web development is plays an important role on business plans and people's lives. One of the key decisions in which both short-term and long-term success of the project depends is choosing the right development platform. Its criticality can be judged by the fact that once a platform is chosen, one has to live with it throughout the software development life cycle. The entire shape of the project depends on the language, operating system, tools, frameworks etc., in short the web development platform chosen. In addition, choosing the right platform is a multi criteria decision making (MCDM problem. We propose a fuzzy analytical hierarchy process model to solve the MCDM problem. We try to tap the real-life modeling potential of fuzzy logic and conjugate it with the commonly used powerful AHP modeling method.

  1. Technology development for high temperature logging tools

    Energy Technology Data Exchange (ETDEWEB)

    Veneruso, A.F.; Coquat, J.A.

    1979-01-01

    A set of prototype, high temperature logging tools (temperature, pressure and flow) were tested successfully to temperatures up to 275/sup 0/C in a Union geothermal well during November 1978 as part of the Geothermal Logging Instrumentation Development Program. This program is being conducted by Sandia Laboratories for the Department of Energy's Division of Geothermal Energy. The progress and plans of this industry based program to develop and apply the high temperature instrumentation technology needed to make reliable geothermal borehole measurements are described. Specifically, this program is upgrading existing sondes for improved high temperature performance, as well as applying new materials (elastomers, polymers, metals and ceramics) and developing component technology such as high temperature cables, cableheads and electronics to make borehole measurements such as formation temperature, flow rate, high resolution pressure and fracture mapping. In order to satisfy critical existing needs, the near term goal is for operation up to 275/sup 0/C and 7000 psi by the end of FY80. The long term goal is for operation up to 350/sup 0/C and 20,000 psi by the end of FY84.

  2. Developing a business analytics methodology: a case study in the foodbank sector

    OpenAIRE

    Hindle, Giles; Vidgen, Richard

    2017-01-01

    The current research seeks to address the following question: how can organizations align their business analytics development projects with their business goals? To pursue this research agenda we adopt an action research framework to develop and apply a business analytics methodology (BAM). The four-stage BAM (problem situation structuring, business model mapping, analytics leverage analysis, and analytics implementation) is not a prescription. Rather, it provides a logical structure and log...

  3. Study of an ultrasound-based process analytical tool for homogenization of nanoparticulate pharmaceutical vehicles.

    Science.gov (United States)

    Cavegn, Martin; Douglas, Ryan; Akkermans, Guy; Kuentz, Martin

    2011-08-01

    There are currently no adequate process analyzers for nanoparticulate viscosity enhancers. This article aims to evaluate ultrasonic resonator technology as a monitoring tool for homogenization of nanoparticulate gels. Aqueous dispersions of colloidal microcrystalline cellulose (MCC) and a mixture of clay particles with xanthan gum were compared with colloidal silicon dioxide in oil. The processing was conducted using a laboratory-scale homogenizing vessel. The study investigated first the homogenization kinetics of the different systems to focus then on process factors in the case of colloidal MCC. Moreover, rheological properties were analyzed offline to assess the structure of the resulting gels. Results showed the suitability of ultrasound velocimetry to monitor the homogenization process. The obtained data were fitted using a novel heuristic model. It was possible to identify characteristic homogenization times for each formulation. The subsequent study of the process factors demonstrated that ultrasonic process analysis was equally sensitive as offline rheological measurements in detecting subtle manufacturing changes. It can be concluded that the ultrasonic method was able to successfully assess homogenization of nanoparticulate viscosity enhancers. This novel technique can become a vital tool for development and production of pharmaceutical suspensions in the future. Copyright © 2011 Wiley-Liss, Inc.

  4. Prioritizing of effective factors on development of medicinal plants cultivation using analytic network process

    Directory of Open Access Journals (Sweden)

    Ghorbanali Rassam

    2014-07-01

    Full Text Available For the overall development of medicinal plants cultivation in Iran, there is a need to identify various effective factors on medicinal plant cultivation. A proper method for identifying the most effective factor on the development of the medicinal plants cultivation is essential. This research conducted in order to prioritizing of the effective criteria for the development of medicinal plant cultivation in North Khorasan province in Iran using Analytical Network Process (ANP method. The multi-criteria decision making (MCDM is suggested to be a viable method for factor selection and the analytic network process (ANP has been used as a tool for MCDM. For this purpose a list of effective factors offered to expert group. Then pair wise comparison questionnaires were distributed between relevant researchers and local producer experts of province to get their opinions about the priority of criteria and sub- criteria. The questionnaires were analyzed using Super Decision software. We illustrated the use of the ANP by ranking main effective factors such as economic, educational-extension services, cultural-social and supportive policies on development of medicinal plants. The main objective of the present study was to develop ANP as a decision making tool for prioritizing factors affecting the development of medicinal plants cultivation. Results showed that the ANP methodology was perfectly suited to tackling the complex interrelations involved in selection factor in this case. Also the results of the process revealed that among the factors, supporting the cultivation of medicinal plants, build the infrastructure for marketing support, having educated farmer and easy access to production input have most impact on the development of medicinal plant cultivation.

  5. Biomarkers as drug development tools: discovery, validation, qualification and use.

    Science.gov (United States)

    Kraus, Virginia B

    2018-06-01

    The 21st Century Cures Act, approved in the USA in December 2016, has encouraged the establishment of the national Precision Medicine Initiative and the augmentation of efforts to address disease prevention, diagnosis and treatment on the basis of a molecular understanding of disease. The Act adopts into law the formal process, developed by the FDA, of qualification of drug development tools, including biomarkers and clinical outcome assessments, to increase the efficiency of clinical trials and encourage an era of molecular medicine. The FDA and European Medicines Agency (EMA) have developed similar processes for the qualification of biomarkers intended for use as companion diagnostics or for development and regulatory approval of a drug or therapeutic. Biomarkers that are used exclusively for the diagnosis, monitoring or stratification of patients in clinical trials are not subject to regulatory approval, although their qualification can facilitate the conduct of a trial. In this Review, the salient features of biomarker discovery, analytical validation, clinical qualification and utilization are described in order to provide an understanding of the process of biomarker development and, through this understanding, convey an appreciation of their potential advantages and limitations.

  6. Effect of Micro Electrical Discharge Machining Process Conditions on Tool Wear Characteristics: Results of an Analytic Study

    DEFF Research Database (Denmark)

    Puthumana, Govindan; P., Rajeev

    2016-01-01

    Micro electrical discharge machining is one of the established techniques to manufacture high aspect ratio features on electrically conductive materials. This paper presents the results and inferences of an analytical study for estimating theeffect of process conditions on tool electrode wear...... characteristicsin micro-EDM process. A new approach with two novel factors anticipated to directly control the material removal mechanism from the tool electrode are proposed; using discharge energyfactor (DEf) and dielectric flushing factor (DFf). The results showed that the correlation between the tool wear rate...... (TWR) and the factors is poor. Thus, individual effects of each factor on TWR are analyzed. The factors selected for the study of individual effects are pulse on-time, discharge peak current, gap voltage and gap flushing pressure. The tool wear rate decreases linearly with an increase in the pulse on...

  7. Learning analytics as a tool for closing the assessment loop in higher education

    OpenAIRE

    Karen D. Mattingly; Margaret C. Rice; Zane L. Berge

    2012-01-01

    This paper examines learning and academic analytics and its relevance to distance education in undergraduate and graduate programs as it impacts students and teaching faculty, and also academic institutions. The focus is to explore the measurement, collection, analysis, and reporting of data as predictors of student success and drivers of departmental process and program curriculum. Learning and academic analytics in higher education is used to predict student success by examining how and wha...

  8. Thermodynamics and structure of liquid surfaces investigated directly with surface analytical tools

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Gunther [Flinders Univ., Adelaide, SA (Australia). Centre for NanoScale Science and Technology; Morgner, Harald [Leipzig Univ. (Germany). Wilhelm Ostwald Inst. for Physical and Theoretical Chemistry

    2017-06-15

    Measuring directly the composition, the distribution of constituents as function of the depth and the orientation of molecules at liquid surfaces is essential for determining physicochemical properties of liquid surfaces. While the experimental tools that have been developed for analyzing solid surfaces can in principal be applied to liquid surfaces, it turned out that they had to be adjusted to the particular challenges imposed by liquid samples, e.g. by the unavoidable vapor pressure and by the mobility of the constituting atoms/molecules. In the present work it is shown, how electron spectroscopy and ion scattering spectroscopy have been used for analyzing liquid surfaces. The emphasis of this review is on using the structural information gained for determining the physicochemical properties of liquid surfaces. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Development of a microrectification apparatus for analytical and preparative applications

    NARCIS (Netherlands)

    Ziogas, A.; Cominos, V.; Kolb, G.A.; Kost, H.J.; Werner, B.; Hessel, V.

    2012-01-01

    The realization of efficient microrectification equipment that can be operated intermittently or continuously is reported. The equipment can be used for both analytical and preparative separations of mixtures of liquid substances. Different binary systems were separated. A theoretical separation

  10. Analytical Models Development of Compact Monopole Vortex Flows

    Directory of Open Access Journals (Sweden)

    Pavlo V. Lukianov

    2017-09-01

    Conclusions. The article contains series of the latest analytical models that describe both laminar and turbulent dynamics of monopole vortex flows which have not been reflected in traditional publications up to the present. The further research must be directed to search of analytical models for the coherent vortical structures in flows of viscous fluids, particularly near curved surfaces, where known in hydromechanics “wall law” is disturbed and heat and mass transfer anomalies take place.

  11. Development of analytical methods for iodine speciation in fresh water

    International Nuclear Information System (INIS)

    Takaku, Yuichi; Ohtsuka, Yoshihito; Hisamatsu, Shun'ichi

    2007-01-01

    Analytical methods for physicochemical speciation of iodine in fresh water samples were developed to elucidate its behavior in the environment. The methods combined inductively coupled plasma mass spectrometry (ICP-MS) with size exclusion high performance liquid chromatography (SEC) or capillary electrophoresis (CE). Freshwater samples were collected from Lake Towada and rivers surrounding the lake. After filtration through a 0.45 μm pore size membrane filter, iodine in the water samples was pre-concentrated with an ultra-filtration filter which had a cut-off size of 10 kDa. The fraction with molecular size over 10 kDa was concentrated to 100 times in the original water, and then introduced into the SEC-ICP-MS. Molecular size chromatograms of all river and lake water samples showed two peaks for iodine concentrations: 40 kDa and 20 kDa. The method for separately determining two valence states of inorganic iodine, I - and IO 3 - , was also developed using the CE-ICP-MS system and it was successfully applied to the fresh water samples. Analysis results of surface water samples in Lake Towada and rivers surrounding the lake indicated that the chemical form of inorganic iodine in all samples was IO 3 - . Additional lake water samples were collected from Lake O-ike-higashi in the Juni-ko area at Shirakami-Sanchi, which is a UNESCO natural world heritage. The lake has a strong thermocline during all seasons; its bottom layer is in a highly reductive state. Depth profiles of I - and IO 3 - clearly showed that I - was not detected in the surface layer, but it was predominant in the bottom layer, and vice versa for IO 3 - . As this separation method is rapid and sensitive, it will be widely used in the future. (author)

  12. European Institutional and Organisational Tools for Maritime Human Resources Development

    OpenAIRE

    Dragomir Cristina

    2012-01-01

    Seafarers need to continuously develop their career, at all stages of their professional life. This paper presents some tools of institutional and organisational career development. At insitutional level there are presented vocational education and training tools provided by the European Union institutions while at organisational level are exemplified some tools used by private crewing companies for maritime human resources assessment and development.

  13. Development of a Framework for Sustainable Outsourcing: Analytic Balanced Scorecard Method (A-BSC

    Directory of Open Access Journals (Sweden)

    Fabio De Felice

    2015-06-01

    Full Text Available Nowadays, many enterprises choose to outsource its non-core business to other enterprises to reduce cost and increase the efficiency. Many enterprises choose to outsource their supply chain management (SCM and leave it to a third-party organization in order to improve their services. The paper proposes an integrated and multicriteria tool useful to monitor and to improve performance in an outsourced supply chain. The Analytic Balanced Scorecard method (A-BSC is proposed as an effective method useful to analyze strategic performance within an outsourced supply chain. The aim of the paper is to present the integration of two methodologies: Balanced Scorecard, a multiple perspective framework for performance assessment, and Analytic Hierarchy Process, a decision-making tool used to prioritize multiple performance perspectives and to generate a unified metric. The development of the framework is aimed to provide a performance analysis to achieve better sustainability performance of supply chain. A real case study concerning a typical value chain is presented.

  14. Developing a Support Tool for Global Product Development Decisions

    DEFF Research Database (Denmark)

    Søndergaard, Erik Stefan; Ahmed-Kristensen, Saeema

    2016-01-01

    This paper investigates how global product development decisions are made through a multiple-case study in three Danish engineering. The paper identifies which information and methods are applied for making decisions and how decision-making can be supported based on previous experience. The paper...... presents results from 51 decisions made in the three companies, and based on the results of the studies a framework for a decision-support tool is outlined and discussed. The paper rounds off with an identification of future research opportunities in the area of global product development and decision-making....

  15. Big data analytics from strategic planning to enterprise integration with tools, techniques, NoSQL, and graph

    CERN Document Server

    Loshin, David

    2013-01-01

    Big Data Analytics will assist managers in providing an overview of the drivers for introducing big data technology into the organization and for understanding the types of business problems best suited to big data analytics solutions, understanding the value drivers and benefits, strategic planning, developing a pilot, and eventually planning to integrate back into production within the enterprise. Guides the reader in assessing the opportunities and value propositionOverview of big data hardware and software architecturesPresents a variety of te

  16. Teaching Analytical Method Transfer through Developing and Validating Then Transferring Dissolution Testing Methods for Pharmaceuticals

    Science.gov (United States)

    Kimaru, Irene; Koether, Marina; Chichester, Kimberly; Eaton, Lafayette

    2017-01-01

    Analytical method transfer (AMT) and dissolution testing are important topics required in industry that should be taught in analytical chemistry courses. Undergraduate students in senior level analytical chemistry laboratory courses at Kennesaw State University (KSU) and St. John Fisher College (SJFC) participated in development, validation, and…

  17. Interactive network analytical tool for instantaneous bespoke interrogation of food safety notifications.

    Science.gov (United States)

    Nepusz, Tamás; Petróczi, Andrea; Naughton, Declan P

    2012-01-01

    The globalization of food supply necessitates continued advances in regulatory control measures to ensure that citizens enjoy safe and adequate nutrition. The aim of this study was to extend previous reports on network analysis relating to food notifications by including an optional filter by type of notification and in cases of contamination, by type of contaminant in the notified foodstuff. A filter function has been applied to enable processing of selected notifications by contaminant or type of notification to i) capture complexity, ii) analyze trends, and iii) identify patterns of reporting activities between countries. The program rapidly assesses nations' roles as transgressor and/or detector for each category of contaminant and for the key class of border rejection. In the open access demonstration version, the majority of notifications in the Rapid Alert System for Food and Feed were categorized by contaminant type as mycotoxin (50.4%), heavy metals (10.9%) or bacteria (20.3%). Examples are given demonstrating how network analytical approaches complement, and in some cases supersede, descriptive statistics such as frequency counts, which may give limited or potentially misleading information. One key feature is that network analysis takes the relationship between transgressor and detector countries, along with number of reports and impact simultaneously into consideration. Furhermore, the indices that compliment the network maps and reflect each country's transgressor and detector activities allow comparisons to be made between (transgressing vs. detecting) as well as within (e.g. transgressing) activities. This further development of the network analysis approach to food safety contributes to a better understanding of the complexity of the effort ensuring food is safe for consumption in the European Union. The unique patterns of the interplay between detectors and transgressors, instantly revealed by our approach, could supplement the intelligence

  18. Interactive network analytical tool for instantaneous bespoke interrogation of food safety notifications.

    Directory of Open Access Journals (Sweden)

    Tamás Nepusz

    Full Text Available The globalization of food supply necessitates continued advances in regulatory control measures to ensure that citizens enjoy safe and adequate nutrition. The aim of this study was to extend previous reports on network analysis relating to food notifications by including an optional filter by type of notification and in cases of contamination, by type of contaminant in the notified foodstuff.A filter function has been applied to enable processing of selected notifications by contaminant or type of notification to i capture complexity, ii analyze trends, and iii identify patterns of reporting activities between countries. The program rapidly assesses nations' roles as transgressor and/or detector for each category of contaminant and for the key class of border rejection. In the open access demonstration version, the majority of notifications in the Rapid Alert System for Food and Feed were categorized by contaminant type as mycotoxin (50.4%, heavy metals (10.9% or bacteria (20.3%. Examples are given demonstrating how network analytical approaches complement, and in some cases supersede, descriptive statistics such as frequency counts, which may give limited or potentially misleading information. One key feature is that network analysis takes the relationship between transgressor and detector countries, along with number of reports and impact simultaneously into consideration. Furhermore, the indices that compliment the network maps and reflect each country's transgressor and detector activities allow comparisons to be made between (transgressing vs. detecting as well as within (e.g. transgressing activities.This further development of the network analysis approach to food safety contributes to a better understanding of the complexity of the effort ensuring food is safe for consumption in the European Union. The unique patterns of the interplay between detectors and transgressors, instantly revealed by our approach, could supplement the

  19. Algorithms for optimized maximum entropy and diagnostic tools for analytic continuation

    Science.gov (United States)

    Bergeron, Dominic; Tremblay, A.-M. S.

    2016-08-01

    Analytic continuation of numerical data obtained in imaginary time or frequency has become an essential part of many branches of quantum computational physics. It is, however, an ill-conditioned procedure and thus a hard numerical problem. The maximum-entropy approach, based on Bayesian inference, is the most widely used method to tackle that problem. Although the approach is well established and among the most reliable and efficient ones, useful developments of the method and of its implementation are still possible. In addition, while a few free software implementations are available, a well-documented, optimized, general purpose, and user-friendly software dedicated to that specific task is still lacking. Here we analyze all aspects of the implementation that are critical for accuracy and speed and present a highly optimized approach to maximum entropy. Original algorithmic and conceptual contributions include (1) numerical approximations that yield a computational complexity that is almost independent of temperature and spectrum shape (including sharp Drude peaks in broad background, for example) while ensuring quantitative accuracy of the result whenever precision of the data is sufficient, (2) a robust method of choosing the entropy weight α that follows from a simple consistency condition of the approach and the observation that information- and noise-fitting regimes can be identified clearly from the behavior of χ2 with respect to α , and (3) several diagnostics to assess the reliability of the result. Benchmarks with test spectral functions of different complexity and an example with an actual physical simulation are presented. Our implementation, which covers most typical cases for fermions, bosons, and response functions, is available as an open source, user-friendly software.

  20. Cross learning synergies between Operation Management content and the use of generic analytic tools

    Directory of Open Access Journals (Sweden)

    Frederic Marimon

    2017-06-01

    By presenting both objectives simultaneously students are found to be more motivated towards working deeply in both objectives. Students know that the theoretical content will be put in practice through certain tools, strengthening the student's interest on the conceptual issues of the chapter. In turn, because students know that they will use a generic tool in a known context, their interests in these tools is reinforced. The result is a cross learning synergy.

  1. Cluster development in the SA tooling industry

    Directory of Open Access Journals (Sweden)

    Von Leipzig, Konrad

    2015-11-01

    Full Text Available This paper explores the concept of clustering in general, analysing research and experiences in different countries and regions, and summarising factors leading to success or contributing to failure of specific cluster initiatives. Based on this, requirements for the establishment of clusters are summarised. Next, initiatives especially in the South African tool and die making (TDM industry are considered. Through a benchmarking approach, the strengths and weaknesses of individual local tool rooms are analysed, and conclusions are drawn particularly about South African characteristics of the industry. From these results, and from structured interviews with individual tool room owners, difficulties in the establishment of a South African tooling cluster are explored, and specific areas of concern are pointed out.

  2. Auxiliary fields as a tool for computing analytical solutions of the Schroedinger equation

    International Nuclear Information System (INIS)

    Silvestre-Brac, Bernard; Semay, Claude; Buisseret, Fabien

    2008-01-01

    We propose a new method to obtain approximate solutions for the Schroedinger equation with an arbitrary potential that possesses bound states. This method, relying on the auxiliary field technique, allows to find in many cases, analytical solutions. It offers a convenient way to study the qualitative features of the energy spectrum of bound states in any potential. In particular, we illustrate our method by solving the case of central potentials with power-law form and with logarithmic form. For these types of potentials, we propose very accurate analytical energy formulae which greatly improves the corresponding formulae that can be found in the literature

  3. Auxiliary fields as a tool for computing analytical solutions of the Schroedinger equation

    Energy Technology Data Exchange (ETDEWEB)

    Silvestre-Brac, Bernard [LPSC Universite Joseph Fourier, Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, Avenue des Martyrs 53, F-38026 Grenoble-Cedex (France); Semay, Claude; Buisseret, Fabien [Groupe de Physique Nucleaire Theorique, Universite de Mons-Hainaut, Academie universitaire Wallonie-Bruxelles, Place du Parc 20, B-7000 Mons (Belgium)], E-mail: silvestre@lpsc.in2p3.fr, E-mail: claude.semay@umh.ac.be, E-mail: fabien.buisseret@umh.ac.be

    2008-07-11

    We propose a new method to obtain approximate solutions for the Schroedinger equation with an arbitrary potential that possesses bound states. This method, relying on the auxiliary field technique, allows to find in many cases, analytical solutions. It offers a convenient way to study the qualitative features of the energy spectrum of bound states in any potential. In particular, we illustrate our method by solving the case of central potentials with power-law form and with logarithmic form. For these types of potentials, we propose very accurate analytical energy formulae which greatly improves the corresponding formulae that can be found in the literature.

  4. Monte Carlo simulation: tool for the calibration in analytical determination of radionuclides

    International Nuclear Information System (INIS)

    Gonzalez, Jorge A. Carrazana; Ferrera, Eduardo A. Capote; Gomez, Isis M. Fernandez; Castro, Gloria V. Rodriguez; Ricardo, Niury Martinez

    2013-01-01

    This work shows how is established the traceability of the analytical determinations using this calibration method. Highlights the advantages offered by Monte Carlo simulation for the application of corrections by differences in chemical composition, density and height of the samples analyzed. Likewise, the results obtained by the LVRA in two exercises organized by the International Agency for Atomic Energy (IAEA) are presented. In these exercises (an intercomparison and a proficiency test) all reported analytical results were obtained based on calibrations in efficiency by Monte Carlo simulation using the DETEFF program

  5. Development of balanced key performance indicators for emergency departments strategic dashboards following analytic hierarchical process.

    Science.gov (United States)

    Safdari, Reza; Ghazisaeedi, Marjan; Mirzaee, Mahboobeh; Farzi, Jebrail; Goodini, Azadeh

    2014-01-01

    Dynamic reporting tools, such as dashboards, should be developed to measure emergency department (ED) performance. However, choosing an effective balanced set of performance measures and key performance indicators (KPIs) is a main challenge to accomplish this. The aim of this study was to develop a balanced set of KPIs for use in ED strategic dashboards following an analytic hierarchical process. The study was carried out in 2 phases: constructing ED performance measures based on balanced scorecard perspectives and incorporating them into analytic hierarchical process framework to select the final KPIs. The respondents placed most importance on ED internal processes perspective especially on measures related to timeliness and accessibility of care in ED. Some measures from financial, customer, and learning and growth perspectives were also selected as other top KPIs. Measures of care effectiveness and care safety were placed as the next priorities too. The respondents placed least importance on disease-/condition-specific "time to" measures. The methodology can be presented as a reference model for development of KPIs in various performance related areas based on a consistent and fair approach. Dashboards that are designed based on such a balanced set of KPIs will help to establish comprehensive performance measurements and fair benchmarks and comparisons.

  6. Develop risk-based procurement management tools for SMEs

    NARCIS (Netherlands)

    Staal, Anne; Hagelaar, Geoffrey; Walhof, Gert; Holman, Richard

    2016-01-01

    This paper provides guidance for developing risk-based management tools to improve the procurement (purchasing) performance of SMEs. Extant academic literature only offers little support on developing such tools and does not consider the wide variety of SMEs. The paper defines a procurement tool for

  7. The Efficacy of Violence Prediction: A Meta-Analytic Comparison of Nine Risk Assessment Tools

    Science.gov (United States)

    Yang, Min; Wong, Stephen C. P.; Coid, Jeremy

    2010-01-01

    Actuarial risk assessment tools are used extensively to predict future violence, but previous studies comparing their predictive accuracies have produced inconsistent findings as a result of various methodological issues. We conducted meta-analyses of the effect sizes of 9 commonly used risk assessment tools and their subscales to compare their…

  8. Online Programs as Tools to Improve Parenting: A meta-analytic review

    NARCIS (Netherlands)

    Prof. Dr. Jo J.M.A Hermanns; Prof. Dr. Ruben R.G. Fukkink; dr. Christa C.C. Nieuwboer

    2013-01-01

    Background. A number of parenting programs, aimed at improving parenting competencies,have recently been adapted or designed with the use of online technologies. Although webbased services have been claimed to hold promise for parent support, a meta-analytic review of online parenting interventions

  9. Online programs as tools to improve parenting: A meta-analytic review

    NARCIS (Netherlands)

    Nieuwboer, C.C.; Fukkink, R.G.; Hermanns, J.M.A.

    2013-01-01

    Background: A number of parenting programs, aimed at improving parenting competencies, have recently been adapted or designed with the use of online technologies. Although web-based services have been claimed to hold promise for parent support, a meta-analytic review of online parenting

  10. Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying.

    Science.gov (United States)

    Vollrath, Ilona; Pauli, Victoria; Friess, Wolfgang; Freitag, Angelika; Hawe, Andrea; Winter, Gerhard

    2017-05-01

    This study investigates the suitability of heat flux measurement as a new technique for monitoring product temperature and critical end points during freeze drying. The heat flux sensor is tightly mounted on the shelf and measures non-invasively (no contact with the product) the heat transferred from shelf to vial. Heat flux data were compared to comparative pressure measurement, thermocouple readings, and Karl Fischer titration as current state of the art monitoring techniques. The whole freeze drying process including freezing (both by ramp freezing and controlled nucleation) and primary and secondary drying was considered. We found that direct measurement of the transferred heat enables more insights into thermodynamics of the freezing process. Furthermore, a vial heat transfer coefficient can be calculated from heat flux data, which ultimately provides a non-invasive method to monitor product temperature throughout primary drying. The end point of primary drying determined by heat flux measurements was in accordance with the one defined by thermocouples. During secondary drying, heat flux measurements could not indicate the progress of drying as monitoring the residual moisture content. In conclusion, heat flux measurements are a promising new non-invasive tool for lyophilization process monitoring and development using energy transfer as a control parameter. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  11. Evaluation And Selection Process of Suppliers Through Analytical Framework: An Emprical Evidence of Evaluation Tool

    Directory of Open Access Journals (Sweden)

    Imeri Shpend

    2015-09-01

    Full Text Available The supplier selection process is very important to companies as selecting the right suppliers that fit companies strategy needs brings drastic savings. Therefore, this paper seeks to address the key area of supplies evaluation from the supplier review perspective. The purpose was to identify the most important criteria for suppliers’ evaluation and develop evaluation tool based on surveyed criteria. The research was conducted through structured questionnaire and the sample focused on small to medium sized companies (SMEs in Greece. In total eighty companies participated in the survey answering the full questionnaire which consisted of questions whether these companies utilize some suppliers’ evaluation criteria and what criteria if any is applied. The main statistical instrument used in the study is Principal Component Analysis (PCA. Thus, the research has shown that the main criteria are: the attitude of the vendor towards the customer, supplier delivery time, product quality and price. Conclusions are made on the suitability and usefulness of suppliers’ evaluation criteria and in way they are applied in enterprises.

  12. 100-K Target Analyte List Development for Soil

    Energy Technology Data Exchange (ETDEWEB)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-K Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  13. 100-F Target Analyte List Development for Soil

    Energy Technology Data Exchange (ETDEWEB)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-F Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  14. Moving standard deviation and moving sum of outliers as quality tools for monitoring analytical precision.

    Science.gov (United States)

    Liu, Jiakai; Tan, Chin Hon; Badrick, Tony; Loh, Tze Ping

    2018-02-01

    An increase in analytical imprecision (expressed as CV a ) can introduce additional variability (i.e. noise) to the patient results, which poses a challenge to the optimal management of patients. Relatively little work has been done to address the need for continuous monitoring of analytical imprecision. Through numerical simulations, we describe the use of moving standard deviation (movSD) and a recently described moving sum of outlier (movSO) patient results as means for detecting increased analytical imprecision, and compare their performances against internal quality control (QC) and the average of normal (AoN) approaches. The power of detecting an increase in CV a is suboptimal under routine internal QC procedures. The AoN technique almost always had the highest average number of patient results affected before error detection (ANPed), indicating that it had generally the worst capability for detecting an increased CV a . On the other hand, the movSD and movSO approaches were able to detect an increased CV a at significantly lower ANPed, particularly for measurands that displayed a relatively small ratio of biological variation to CV a. CONCLUSION: The movSD and movSO approaches are effective in detecting an increase in CV a for high-risk measurands with small biological variation. Their performance is relatively poor when the biological variation is large. However, the clinical risks of an increase in analytical imprecision is attenuated for these measurands as an increased analytical imprecision will only add marginally to the total variation and less likely to impact on the clinical care. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  15. Analytical tools and functions of GIS in the process control and decision support of mining company

    Directory of Open Access Journals (Sweden)

    Semrád Peter

    2001-12-01

    Full Text Available The development of computer techniques, the increase in demands for the professional and possible fastest data processing, as well as for the fluency and efficiency of information gaining, exchanging and providing has a strong influence on forming the new generation of information technologies - Geografic Information Systems (GIS that rose in the second half of the twentieth century.Advancement in this area is still progressing and GIS gradually find the enforcement in individual fields where they play a great role in the process control and decision support. Nowadays, there are applications in mining and geology, where are used especially at processing and evaluating of mining - geological documentation, optimalization of mining and technical processes, planning, distributing and managing of mining as well as economic analysis that are important in terms of investment decisions to mining business.GIS are the systems for the effective keeping, updating, processing, analysing, modelling, simulating and presenting geographically oriented information. We can identify them as computer systems helping to solve real problems that should be normally required to solve by human expert.Well equipped GIS have graphic ability and accordingly manage descriptive (attribute data. They are able to secure mutual connection between graphical and descriptive data and in addition to command countless number of functions that enable the execution of spatial analysis. This fact is very important in mining and geological application.There are exploited mostly geostatistical analysis (e. g. modelling of distribution valuable and harmful components of mineral resouce in a mineral deposit, surface modelling and surface model analysis (e. g. at modelling the subsidence of mining territory, different methods of creating spatial and attribute queries about database for seeking necessary data (e. g. to find all mining blocks of deposit that meet required conditions and to

  16. [COMETE: a tool to develop psychosocial competences in patient education].

    Science.gov (United States)

    Saugeron, Benoit; Sonnier, Pierre; Marchais, Stéphanie

    2016-01-01

    This article presents a detailed description of the development and use of the COMETE tool. The COMETE tool is designed to help medical teams identify, develop or evaluate psychosocial skills in patient education and counselling. This tool, designed in the form of a briefcase, proposes methodological activities and cards that assess psychosocial skills during a shared educational assessment, group meetings or during an individual evaluation. This tool is part of a support approach for medical teams caring for patients with chronic diseases.

  17. Workshop on Software Development Tools for Petascale Computing

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, Jeffrey [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Georgia Inst. of Technology, Atlanta, GA (United States)

    2007-08-01

    Petascale computing systems will soon be available to the DOE science community. Recent studies in the productivity of HPC platforms point to better software environments as a key enabler to science on these systems. To prepare for the deployment and productive use of these petascale platforms, the DOE science and general HPC community must have the software development tools, such as performance analyzers and debuggers that meet application requirements for scalability, functionality, reliability, and ease of use. In this report, we identify and prioritize the research opportunities in the area of software development tools for high performance computing. To facilitate this effort, DOE hosted a group of 55 leading international experts in this area at the Software Development Tools for PetaScale Computing (SDTPC) Workshop, which was held in Washington, D.C. on August 1 and 2, 2007. Software development tools serve as an important interface between the application teams and the target HPC architectures. Broadly speaking, these roles can be decomposed into three categories: performance tools, correctness tools, and development environments. Accordingly, this SDTPC report has four technical thrusts: performance tools, correctness tools, development environment infrastructures, and scalable tool infrastructures. The last thrust primarily targets tool developers per se, rather than end users. Finally, this report identifies non-technical strategic challenges that impact most tool development. The organizing committee emphasizes that many critical areas are outside the scope of this charter; these important areas include system software, compilers, and I/O.

  18. An analytical model for the study of a small LFR core dynamics: development and benchmark

    International Nuclear Information System (INIS)

    Bortot, S.; Cammi, A.; Lorenzi, S.; Moisseytsev, A.

    2011-01-01

    An analytical model for the study of a small Lead-cooled Fast Reactor (LFR) control-oriented dynamics has been developed aimed at providing a useful, very flexible and straightforward, though accurate, tool allowing relatively quick transient design-basis and stability analyses. A simplified lumped-parameter approach has been adopted to couple neutronics and thermal-hydraulics: the point-kinetics approximation has been employed and an average-temperature heat-exchange model has been implemented. The reactor transient responses following postulated accident initiators such as Unprotected Control Rod Withdrawal (UTOP), Loss of Heat Sink (ULOHS) and Loss of Flow (ULOF) have been studied for a MOX and a metal-fuelled core at the Beginning of Cycle (BoC) and End of Cycle (EoC) configurations. A benchmark analysis has been then performed by means of the SAS4A/SASSYS-1 Liquid Metal Reactor Code System, in which a core model based on three representative channels has been built with the purpose of providing verification for the analytical outcomes and indicating how the latter relate to more realistic one-dimensional calculations. As a general result, responses concerning the main core characteristics (namely, power, reactivity, etc.) have turned out to be mutually consistent in terms of both steady-state absolute figures and transient developments, showing discrepancies of the order of only some percents, thus confirming a very satisfactory agreement. (author)

  19. Specialized case tools for the development of the accounting ...

    African Journals Online (AJOL)

    The paper presents an approach to building specialized CASE tools for the development of accounting applications. These tools form an integrated development environment allowing the computer aided development of the different applications in this field. This development environment consists of a formula interpreter, ...

  20. Visualizing the Geography of the Diseases of China: Western Disease Maps from Analytical Tools to Tools of Empire, Sovereignty, and Public Health Propaganda, 1878-1929.

    Science.gov (United States)

    Hanson, Marta

    2017-09-01

    Argument This article analyzes for the first time the earliest western maps of diseases in China spanning fifty years from the late 1870s to the end of the 1920s. The 24 featured disease maps present a visual history of the major transformations in modern medicine from medical geography to laboratory medicine wrought on Chinese soil. These medical transformations occurred within new political formations from the Qing dynasty (1644-1911) to colonialism in East Asia (Hong Kong, Taiwan, Manchuria, Korea) and hypercolonialism within China (Tianjin, Shanghai, Amoy) as well as the new Republican Chinese nation state (1912-49). As a subgenre of persuasive graphics, physicians marshaled disease maps for various rhetorical functions within these different political contexts. Disease maps in China changed from being mostly analytical tools to functioning as tools of empire, national sovereignty, and public health propaganda legitimating new medical concepts, public health interventions, and political structures governing over human and non-human populations.

  1. The Development of Proofs in Analytical Mathematics for Undergraduate Students

    Science.gov (United States)

    Ali, Maselan; Sufahani, Suliadi; Hasim, Nurnazifa; Saifullah Rusiman, Mohd; Roslan, Rozaini; Mohamad, Mahathir; Khalid, Kamil

    2018-04-01

    Proofs in analytical mathematics are essential parts of mathematics, difficult to learn because its underlying concepts are not visible. This research consists of problems involving logic and proofs. In this study, a short overview was provided on how proofs in analytical mathematics were used by university students. From the results obtained, excellent students obtained better scores compared to average and poor students. The research instruments used in this study consisted of two parts: test and interview. In this way, analysis of students’ actual performances can be obtained. The result of this study showed that the less able students have fragile conceptual and cognitive linkages but the more able students use their strong conceptual linkages to produce effective solutions

  2. Learning analytics as a tool for closing the assessment loop in higher education

    Directory of Open Access Journals (Sweden)

    Karen D. Mattingly

    2012-09-01

    Full Text Available This paper examines learning and academic analytics and its relevance to distance education in undergraduate and graduate programs as it impacts students and teaching faculty, and also academic institutions. The focus is to explore the measurement, collection, analysis, and reporting of data as predictors of student success and drivers of departmental process and program curriculum. Learning and academic analytics in higher education is used to predict student success by examining how and what students learn and how success is supported by academic programs and institutions. The paper examines what is being done to support students, whether or not it is effective, and if not why, and what educators can do. The paper also examines how these data can be used to create new metrics and inform a continuous cycle of improvement. It presents examples of working models from a sample of institutions of higher education: The Graduate School of Medicine at the University of Wollongong, the University of Michigan, Purdue University, and the University of Maryland, Baltimore County. Finally, the paper identifies considerations and recommendations for using analytics and offer suggestions for future research.

  3. Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying.

    Science.gov (United States)

    Brouckaert, Davinia; De Meyer, Laurens; Vanbillemont, Brecht; Van Bockstal, Pieter-Jan; Lammens, Joris; Mortier, Séverine; Corver, Jos; Vervaet, Chris; Nopens, Ingmar; De Beer, Thomas

    2018-04-03

    Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring because it combines the chemical selectivity of vibrational spectroscopy with spatial information. Whereas traditional near-infrared spectroscopy is an attractive technique for water content determination and solid-state investigation of lyophilized products, chemical imaging opens up possibilities for assessing the homogeneity of these critical quality attributes (CQAs) throughout the entire product. In this contribution, we aim to evaluate NIR-CI as a process analytical technology (PAT) tool for at-line inspection of continuously freeze-dried pharmaceutical unit doses based on spin freezing. The chemical images of freeze-dried mannitol samples were resolved via multivariate curve resolution, allowing us to visualize the distribution of mannitol solid forms throughout the entire cake. Second, a mannitol-sucrose formulation was lyophilized with variable drying times for inducing changes in water content. Analyzing the corresponding chemical images via principal component analysis, vial-to-vial variations as well as within-vial inhomogeneity in water content could be detected. Furthermore, a partial least-squares regression model was constructed for quantifying the water content in each pixel of the chemical images. It was hence concluded that NIR-CI is inherently a most promising PAT tool for continuously monitoring freeze-dried samples. Although some practicalities are still to be solved, this analytical technique could be applied in-line for CQA evaluation and for detecting the drying end point.

  4. Analytical developments in ICP-MS for arsenic and selenium speciation. Application to granitic waters

    International Nuclear Information System (INIS)

    Garraud, Herve

    1999-01-01

    Nuclear waste storage in geological areas needs the understanding of the physico-chemistry of groundwaters interactions with surrounding rocks. Redox potential measurements and speciation, calculated from geochemical modelling are not significant for the determination of water reactivity. We have thus chosen to carry out experimental speciation by developing sensitive analytical tools with respect of specie chemical identity. We have studied two redox indicators from reference sites (thermal waters from Pyrenees, France): arsenic and selenium. At first, we have determined the concentrations in major ions (sulphide, sulphate, chloride, fluoride, carbonate, Na, K, Ca). Speciation was conducted by HPLC hyphenated to quadrupole ICP-MS and high resolution ICP-MS. These analyses have shown the presence of two new arsenic species in solution, in addition of a great reactivity of these waters during stability studies. A sampling, storage and analysis method is described. (author) [fr

  5. Prognostic risk estimates of patients with multiple sclerosis and their physicians: comparison to an online analytical risk counseling tool.

    Directory of Open Access Journals (Sweden)

    Christoph Heesen

    Full Text Available BACKGROUND: Prognostic counseling in multiple sclerosis (MS is difficult because of the high variability of disease progression. Simultaneously, patients and physicians are increasingly confronted with making treatment decisions at an early stage, which requires taking individual prognoses into account to strike a good balance between benefits and harms of treatments. It is therefore important to understand how patients and physicians estimate prognostic risk, and whether and how these estimates can be improved. An online analytical processing (OLAP tool based on pooled data from placebo cohorts of clinical trials offers short-term prognostic estimates that can be used for individual risk counseling. OBJECTIVE: The aim of this study was to clarify if personalized prognostic information as presented by the OLAP tool is considered useful and meaningful by patients. Furthermore, we used the OLAP tool to evaluate patients' and physicians' risk estimates. Within this evaluation process we assessed short-time prognostic risk estimates of patients with MS (final n = 110 and their physicians (n = 6 and compared them with the estimates of OLAP. RESULTS: Patients rated the OLAP tool as understandable and acceptable, but to be only of moderate interest. It turned out that patients, physicians, and the OLAP tool ranked patients similarly regarding their risk of disease progression. Both patients' and physicians' estimates correlated most strongly with those disease covariates that the OLAP tool's estimates also correlated with most strongly. Exposure to the OLAP tool did not change patients' risk estimates. CONCLUSION: While the OLAP tool was rated understandable and acceptable, it was only of modest interest and did not change patients' prognostic estimates. The results suggest, however, that patients had some idea regarding their prognosis and which factors were most important in this regard. Future work with OLAP should assess long-term prognostic

  6. Prognostic risk estimates of patients with multiple sclerosis and their physicians: comparison to an online analytical risk counseling tool.

    Science.gov (United States)

    Heesen, Christoph; Gaissmaier, Wolfgang; Nguyen, Franziska; Stellmann, Jan-Patrick; Kasper, Jürgen; Köpke, Sascha; Lederer, Christian; Neuhaus, Anneke; Daumer, Martin

    2013-01-01

    Prognostic counseling in multiple sclerosis (MS) is difficult because of the high variability of disease progression. Simultaneously, patients and physicians are increasingly confronted with making treatment decisions at an early stage, which requires taking individual prognoses into account to strike a good balance between benefits and harms of treatments. It is therefore important to understand how patients and physicians estimate prognostic risk, and whether and how these estimates can be improved. An online analytical processing (OLAP) tool based on pooled data from placebo cohorts of clinical trials offers short-term prognostic estimates that can be used for individual risk counseling. The aim of this study was to clarify if personalized prognostic information as presented by the OLAP tool is considered useful and meaningful by patients. Furthermore, we used the OLAP tool to evaluate patients' and physicians' risk estimates. Within this evaluation process we assessed short-time prognostic risk estimates of patients with MS (final n = 110) and their physicians (n = 6) and compared them with the estimates of OLAP. Patients rated the OLAP tool as understandable and acceptable, but to be only of moderate interest. It turned out that patients, physicians, and the OLAP tool ranked patients similarly regarding their risk of disease progression. Both patients' and physicians' estimates correlated most strongly with those disease covariates that the OLAP tool's estimates also correlated with most strongly. Exposure to the OLAP tool did not change patients' risk estimates. While the OLAP tool was rated understandable and acceptable, it was only of modest interest and did not change patients' prognostic estimates. The results suggest, however, that patients had some idea regarding their prognosis and which factors were most important in this regard. Future work with OLAP should assess long-term prognostic estimates and clarify its usefulness for patients and physicians

  7. Analytical and clinical performances of immunoradiometric assay of total and free PSA developed locally

    International Nuclear Information System (INIS)

    Boucekkine, N.; Korso, R.; Bellazoug, K.; Ferd, N.; Bouyoucef, S.E.; Boudjemai, S.; Benzaid, A.; Bouhila, Z.

    2002-01-01

    A specific assay was developed for total and free PSA (PSAt, PSAf). Both assay use a two site IRMA with polyclonal anti PSA antibodies coated on tubes. Polyclonal antibodies were obtained after rabbit's immunisation using an under skin injection of pure PSA in multiple site. For quantification, two monoclonal antibodies were selected, the first highly specific to free PSA and the second recognising both free and bound PSA. A correlation study was performed comparatively with two commercial kits from CIS Bio and Immunotech. For that purpose, 464 serums samples ranging from 0.5 ng/ml to 3399 ng/ml were used to characterise the analytical performance of the new test. The analytical detection limit of the new test was equal to 0.05 ng/ml for the total PSA and 0.02ng/ml for the free PSA. The within run and between-day coefficients of variation were to 20 ng/ml. For BPH, no significant difference was found between the three test for the ratio PSAf/PSAt using a cut off of 14% (all were>to 14%). For the 120 patients with PC, all PSAt were > to 2 ng/ml. However the mean value of PSAt was higher for the commercial kits (14.74 ng/ml against 12.48ng/ml for the new test) but all ratio of PSAf/PSAt for the 120 newly diagnosed cancer were <14%. In conclusion, our immunoradiometric assay developed locally has a good analytical performance and its outputs are well correlated to clinical findings in prostate disease. Furthermore, a cut off of 14% for the ratio PSAf/PSAt appears to be the most accurate tools to depict a prostate cancer

  8. The development of a visualization tool for displaying analysis and test results

    International Nuclear Information System (INIS)

    Uncapher, W.L.; Ammerman, D.J.; Ludwigsen, J.S.; Wix, S.D.

    1995-01-01

    The evaluation and certification of packages for transportation of radioactive materials is performed by analysis, testing, or a combination of both. Within the last few years, many transport packages that were certified have used a combination of analysis and testing. The ability to combine and display both kinds of data with interactive graphical tools allows a faster and more complete understanding of the response of the package to these environments. Sandia National Laboratories has developed an initial version of a visualization tool that allows the comparison and display of test and of analytical data as part of a Department of Energy-sponsored program to support advanced analytical techniques and test methodologies. The capability of the tool extends to both mechanical (structural) and thermal data

  9. Ceramic cutting tools materials, development and performance

    CERN Document Server

    Whitney, E Dow

    1994-01-01

    Interest in ceramics as a high speed cutting tool material is based primarily on favorable material properties. As a class of materials, ceramics possess high melting points, excellent hardness and good wear resistance. Unlike most metals, hardness levels in ceramics generally remain high at elevated temperatures which means that cutting tip integrity is relatively unaffected at high cutting speeds. Ceramics are also chemically inert against most workmetals.

  10. Developing Learning Analytics Design Knowledge in the "Middle Space": The Student Tuning Model and Align Design Framework for Learning Analytics Use

    Science.gov (United States)

    Wise, Alyssa Friend; Vytasek, Jovita Maria; Hausknecht, Simone; Zhao, Yuting

    2016-01-01

    This paper addresses a relatively unexplored area in the field of learning analytics: how analytics are taken up and used as part of teaching and learning processes. Initial steps are taken towards developing design knowledge for this "middle space," with a focus on students as analytics users. First, a core set of challenges for…

  11. Long range manipulator development and experiments with dismantling tools

    International Nuclear Information System (INIS)

    Mueller, K.

    1993-01-01

    An existing handling system (EMIR) was used as a carrier system for various tools for concrete dismantling and radiation protection monitoring. It combined the advantages of long reach and high payload with highly dexterous kinematics. This system was enhanced mechanically to allow the use of different tools. Tool attachment devices for automatic tool exchange were investigated as well as interfaces (electric, hydraulic, compressed air, cooling water and signals). The control system was improved with regard to accuracy and sensor data processing. Programmable logic controller functions for tool control were incorporated. A free field mockup of the EMIR was build that allowed close simulation of dismantling scenarios without radioactive inventory. Aged concrete was provided for the integration tests. The development scheduled included the basic concept investigation; the development of tools and sensors; the EMIR hardware enhancement including a tool exchange; the adaption of tools and mockup and the final evaluation of the system during experiments

  12. Role of analytical chemistry in the development of nuclear fuels

    International Nuclear Information System (INIS)

    Ramakumar, K.L.

    2012-01-01

    Analytical chemistry is indispensable and plays a pivotal role in the entire gamut of nuclear fuel cycle activities starting from ore refining, conversion, nuclear fuel fabrication, reactor operation, nuclear fuel reprocessing to waste management. As the fuel is the most critical component of the reactor where the fissions take place to produce power, extreme care should be taken to qualify the fuel. For example, in nuclear fuel fabrication, depending upon the reactor system, selection of nuclear fuel has to be made. The fuel for thermal reactors is normally uranium oxide either natural or slightly enriched. For research reactors it can be uranium metal or alloy. The fuel for FBR can be metal, alloy, oxide, carbide or nitride. India is planning an advanced heavy water reactor for utilization of vast resources of thorium in the country. Also research is going on to identify suitable metallic/alloy fuels for our future fast reactors and possible use in fast breeder test reactor. Other advanced fuel materials are also being investigated for thermal reactors for realizing increased performance levels. For example, advanced fuels made from UO 2 doped with Cr 2 O 3 and Al 2 O 3 are being suggested in LWR applications. These have shown to facilitate pellet densification during sintering and enlarge the pellet grain size. The chemistry of these materials has to be understood during the preparation to the stringent specification. A number of analytical parameters need to be determined as a part of chemical quality control of nuclear materials. Myriad of analytical techniques starting from the classical to sophisticated instrumentation techniques are available for this purpose. Insatiable urge of the analytical chemist enables to devise and adopt new superior methodologies in terms of reduction in the time of analysis, improvement in the measurement precision and accuracy, simplicity of the technique itself etc. Chemical quality control provides a means to ensure that the

  13. The development of a post occupancy evaluation tool for primary schools: learner comfort assessment tool (LCAT)

    CSIR Research Space (South Africa)

    Motsatsi, L

    2015-12-01

    Full Text Available in order to facilitate teaching and learning. The aim of this study was to develop a Post Occupational Evaluation (POE) tool to assess learner comfort in relation to indoor environmental quality in the classroom. The development of POE tool followed a...

  14. Newspaper Reading among College Students in Development of Their Analytical Ability

    Science.gov (United States)

    Kumar, Dinesh

    2009-01-01

    The study investigated the newspaper reading among college students in development of their analytical ability. Newspapers are one of the few sources of information that are comprehensive, interconnected and offered in one format. The main objective of the study was to find out the development of the analytical ability among college students by…

  15. An Analytic Hierarchy Process for School Quality and Inspection: Model Development and Application

    Science.gov (United States)

    Al Qubaisi, Amal; Badri, Masood; Mohaidat, Jihad; Al Dhaheri, Hamad; Yang, Guang; Al Rashedi, Asma; Greer, Kenneth

    2016-01-01

    Purpose: The purpose of this paper is to develop an analytic hierarchy planning-based framework to establish criteria weights and to develop a school performance system commonly called school inspections. Design/methodology/approach: The analytic hierarchy process (AHP) model uses pairwise comparisons and a measurement scale to generate the…

  16. Preparation of standard hair material and development of analytical methodology

    International Nuclear Information System (INIS)

    Gangadharan, S.; Walvekar, A.P.; Ali, M.M.; Thantry, S.S.; Verma, R.; Devi, R.

    1995-01-01

    The concept of the use of human scalp hair as a first level indicator of exposure to inorganic pollutants has been established by us earlier. Efforts towards the preparation of a hair reference material are described. The analytical approaches for the determination of total mercury by cold vapour AAS and INAA and of methylmercury by extraction combined with gas chromatography coupled to an ECD are summarized with results on some of the samples analyzed, including the stability of values over a period of time of storage. (author)

  17. System Architecture Development for Energy and Water Infrastructure Data Management and Geovisual Analytics

    Science.gov (United States)

    Berres, A.; Karthik, R.; Nugent, P.; Sorokine, A.; Myers, A.; Pang, H.

    2017-12-01

    Building an integrated data infrastructure that can meet the needs of a sustainable energy-water resource management requires a robust data management and geovisual analytics platform, capable of cross-domain scientific discovery and knowledge generation. Such a platform can facilitate the investigation of diverse complex research and policy questions for emerging priorities in Energy-Water Nexus (EWN) science areas. Using advanced data analytics, machine learning techniques, multi-dimensional statistical tools, and interactive geovisualization components, such a multi-layered federated platform is being developed, the Energy-Water Nexus Knowledge Discovery Framework (EWN-KDF). This platform utilizes several enterprise-grade software design concepts and standards such as extensible service-oriented architecture, open standard protocols, event-driven programming model, enterprise service bus, and adaptive user interfaces to provide a strategic value to the integrative computational and data infrastructure. EWN-KDF is built on the Compute and Data Environment for Science (CADES) environment in Oak Ridge National Laboratory (ORNL).

  18. Holistic Framework For Establishing Interoperability of Heterogeneous Software Development Tools

    National Research Council Canada - National Science Library

    Puett, Joseph

    2003-01-01

    This dissertation presents a Holistic Framework for Software Engineering (HFSE) that establishes collaborative mechanisms by which existing heterogeneous software development tools and models will interoperate...

  19. Holistic Framework For Establishing Interoperability of Heterogeneous Software Development Tools

    National Research Council Canada - National Science Library

    Puett, Joseph

    2003-01-01

    ...; however, this research focuses on establishing a holistic approach over the entire development effort where unrealized synergies and dependencies between all of the tools' artifacts can be visualized...

  20. Development and testing of analytical models for the pebble bed type HTRs

    International Nuclear Information System (INIS)

    Huda, M.Q.; Obara, T.

    2008-01-01

    The pebble bed type gas cooled high temperature reactor (HTR) appears to be a good candidate for the next generation nuclear reactor technology. These reactors have unique characteristics in terms of the randomness in geometry, and require special techniques to analyze their systems. This study includes activities concerning the testing of computational tools and the qualification of models. Indeed, it is essential that the validated analytical tools be available to the research community. From this viewpoint codes like MCNP, ORIGEN and RELAP5, which have been used in nuclear industry for many years, are selected to identify and develop new capabilities needed to support HTR analysis. The geometrical model of the full reactor is obtained by using lattice and universe facilities provided by MCNP. The coupled MCNP-ORIGEN code is used to estimate the burnup and the refuelling scheme. Results obtained from Monte Carlo analysis are interfaced with RELAP5 to analyze the thermal hydraulics and safety characteristics of the reactor. New models and methodologies are developed for several past and present experimental and prototypical facilities that were based on HTR pebble bed concepts. The calculated results are compared with available experimental data and theoretical evaluations showing very good agreement. The ultimate goal of the validation of the computer codes for pebble bed HTR applications is to acquire and reinforce the capability of these general purpose computer codes for performing HTR core design and optimization studies

  1. New method development in prehistoric stone tool research: evaluating use duration and data analysis protocols.

    Science.gov (United States)

    Evans, Adrian A; Macdonald, Danielle A; Giusca, Claudiu L; Leach, Richard K

    2014-10-01

    Lithic microwear is a research field of prehistoric stone tool (lithic) analysis that has been developed with the aim to identify how stone tools were used. It has been shown that laser scanning confocal microscopy has the potential to be a useful quantitative tool in the study of prehistoric stone tool function. In this paper, two important lines of inquiry are investigated: (1) whether the texture of worn surfaces is constant under varying durations of tool use, and (2) the development of rapid objective data analysis protocols. This study reports on the attempt to further develop these areas of study and results in a better understanding of the complexities underlying the development of flexible analytical algorithms for surface analysis. The results show that when sampling is optimised, surface texture may be linked to contact material type, independent of use duration. Further research is needed to validate this finding and test an expanded range of contact materials. The use of automated analytical protocols has shown promise but is only reliable if sampling location and scale are defined. Results suggest that the sampling protocol reports on the degree of worn surface invasiveness, complicating the ability to investigate duration related textural characterisation. Copyright © 2014. Published by Elsevier Ltd.

  2. Characterization, thermal stability studies, and analytical method development of Paromomycin for formulation development.

    Science.gov (United States)

    Khan, Wahid; Kumar, Neeraj

    2011-06-01

    Paromomycin (PM) is an aminoglycoside antibiotic, first isolated in the 1950s, and approved in 2006 for treatment of visceral leishmaniasis. Although isolated six decades back, sufficient information essential for development of pharmaceutical formulation is not available for PM. The purpose of this paper was to determine thermal stability and development of new analytical method for formulation development of PM. PM was characterized by thermoanalytical (DSC, TGA, and HSM) and by spectroscopic (FTIR) techniques and these techniques were used to establish thermal stability of PM after heating PM at 100, 110, 120, and 130 °C for 24 h. Biological activity of these heated samples was also determined by microbiological assay. Subsequently, a simple, rapid and sensitive RP-HPLC method for quantitative determination of PM was developed using pre-column derivatization with 9-fluorenylmethyl chloroformate. The developed method was applied to estimate PM quantitatively in two parenteral dosage forms. PM was successfully characterized by various stated techniques. These techniques indicated stability of PM for heating up to 120 °C for 24 h, but when heated at 130 °C, PM is liable to degradation. This degradation is also observed in microbiological assay where PM lost ∼30% of its biological activity when heated at 130 °C for 24 h. New analytical method was developed for PM in the concentration range of 25-200 ng/ml with intra-day and inter-day variability of stability of PM was determined successfully. Developed analytical method was found sensitive, accurate, and precise for quantification of PM. Copyright © 2010 John Wiley & Sons, Ltd. Copyright © 2010 John Wiley & Sons, Ltd.

  3. State-of-the-Art of (Bio)Chemical Sensor Developments in Analytical Spanish Groups

    Science.gov (United States)

    Plata, María Reyes; Contento, Ana María; Ríos, Angel

    2010-01-01

    (Bio)chemical sensors are one of the most exciting fields in analytical chemistry today. The development of these analytical devices simplifies and miniaturizes the whole analytical process. Although the initial expectation of the massive incorporation of sensors in routine analytical work has been truncated to some extent, in many other cases analytical methods based on sensor technology have solved important analytical problems. Many research groups are working in this field world-wide, reporting interesting results so far. Modestly, Spanish researchers have contributed to these recent developments. In this review, we summarize the more representative achievements carried out for these groups. They cover a wide variety of sensors, including optical, electrochemical, piezoelectric or electro-mechanical devices, used for laboratory or field analyses. The capabilities to be used in different applied areas are also critically discussed. PMID:22319260

  4. Analytical tools for managing rock fall hazards in Australian coal mine roadways

    Energy Technology Data Exchange (ETDEWEB)

    Ross Seedsman; Nick Gordon; Naj Aziz [University of Wollongong (Australia)

    2009-03-15

    This report provides a reference source for the design of ground control measures in coal mine roadways using analytical methods. Collapse models are provided for roof and rib. The roof models recognise that different collapse modes can apply in different stress fields - high, intermediate, and zero compressive stresses. The rib models draw analogies to rock slope stability and also the impact of high vertical stresses. Methods for determining support or reinforcement requirements are provided. Suspension of collapsed masses is identified as the basis for roof support in both very high and zero compressive stress regimes. Reinforcement of bedding discontinuities is advocated for intermediate compressive stresses. For the ribs, restraint of coal blocks defined by pre-existing joints or by mining induced fractures is required.

  5. PLS2 regression as a tool for selection of optimal analytical modality

    DEFF Research Database (Denmark)

    Madsen, Michael; Esbensen, Kim

    Intelligent use of modern process analysers allows process technicians and engineers to look deep into the dynamic behaviour of production systems. This opens up for a plurality of new possibilities with respect to process optimisation. Oftentimes, several instruments representing different...... technologies and price classes are able to decipher relevant process information simultaneously. The question then is: how to choose between available technologies without compromising the quality and usability of the data. We apply PLS2 modelling to quantify the relative merits of competing, or complementing......, analytical modalities. We here present results from a feasibility study, where Fourier Transform Near InfraRed (FT-NIR), Fourier Transform Mid InfraRed (FT-MIR), and Raman laser spectroscopy were applied on the same set of samples obtained from a pilot-scale beer brewing process. Quantitative PLS1 models...

  6. Applying CASE Tools for On-Board Software Development

    Science.gov (United States)

    Brammer, U.; Hönle, A.

    For many space projects the software development is facing great pressure with respect to quality, costs and schedule. One way to cope with these challenges is the application of CASE tools for automatic generation of code and documentation. This paper describes two CASE tools: Rhapsody (I-Logix) featuring UML and ISG (BSSE) that provides modeling of finite state machines. Both tools have been used at Kayser-Threde in different space projects for the development of on-board software. The tools are discussed with regard to the full software development cycle.

  7. Challenges in the development of analytical soil compaction models

    DEFF Research Database (Denmark)

    Keller, Thomas; Lamandé, Mathieu

    2010-01-01

    and recommendations for the prevention of soil compaction often rely on simulation models. This paper highlights some issues that need further consideration in order to improve soil compaction modelling, with the focus on analytical models. We discuss the different issues based on comparisons between experimental......Soil compaction can cause a number of environmental and agronomic problems (e.g. flooding, erosion, leaching of agrochemicals to recipient waters, emission of greenhouse gases to the atmosphere, crop yield losses), resulting in significant economic damage to society and agriculture. Strategies...... data and model simulations. The upper model boundary condition (i.e. contact area and stresses at the tyre-soil interface) is highly influential in stress propagation, but knowledge on the effects of loading and soil conditions on the upper model boundary condition is inadequate. The accuracy of stress...

  8. Water Loss Management: Tools and Methods for Developing Countries

    OpenAIRE

    Mutikanga, H.E.

    2012-01-01

    Water utilities in developing countries are struggling to provide customers with a reliable level of service due to their peculiar water distribution characteristics including poorly zoned networks with irregular supply operating under restricted budgets. These unique conditions demand unique tools and methods for water loss control. Water loss management: Tools and Methods for Developing Countries provide a decision support toolbox (appropriate tools and methodologies) for assessing, quantif...

  9. Artificial intelligence tool development and applications to nuclear power

    International Nuclear Information System (INIS)

    Naser, J.A.

    1987-01-01

    Two parallel efforts are being performed at the Electric Power Research Institute (EPRI) to help the electric utility industry take advantage of the expert system technology. The first effort is the development of expert system building tools, which are tailored to electric utility industry applications. The second effort is the development of expert system applications. These two efforts complement each other. The application development tests the tools and identifies additional tool capabilities that are required. The tool development helps define the applications that can be successfully developed. Artificial intelligence, as demonstrated by the developments described is being established as a credible technological tool for the electric utility industry. The challenge to transferring artificial intelligence technology and an understanding of its potential to the electric utility industry is to gain an understanding of the problems that reduce power plant performance and identify which can be successfully addressed using artificial intelligence

  10. On-line near infrared spectroscopy as a Process Analytical Technology (PAT) tool to control an industrial seeded API crystallization.

    Science.gov (United States)

    Schaefer, C; Lecomte, C; Clicq, D; Merschaert, A; Norrant, E; Fotiadu, F

    2013-09-01

    The final step of an active pharmaceutical ingredient (API) manufacturing synthesis process consists of a crystallization during which the API and residual solvent contents have to be quantified precisely in order to reach a predefined seeding point. A feasibility study was conducted to demonstrate the suitability of on-line NIR spectroscopy to control this step in line with new version of the European Medicines Agency (EMA) guideline [1]. A quantitative method was developed at laboratory scale using statistical design of experiments (DOE) and multivariate data analysis such as principal component analysis (PCA) and partial least squares (PLS) regression. NIR models were built to quantify the API in the range of 9-12% (w/w) and to quantify the residual methanol in the range of 0-3% (w/w). To improve the predictive ability of the models, the development procedure encompassed: outliers elimination, optimum model rank definition, spectral range and spectral pre-treatment selection. Conventional criteria such as, number of PLS factors, R(2), root mean square errors of calibration, cross-validation and prediction (RMSEC, RMSECV, RMSEP) enabled the selection of three model candidates. These models were tested in the industrial pilot plant during three technical campaigns. Results of the most suitable models were evaluated against to the chromatographic reference methods. Maximum relative bias of 2.88% was obtained about API target content. Absolute bias of 0.01 and 0.02% (w/w) respectively were achieved at methanol content levels of 0.10 and 0.13% (w/w). The repeatability was assessed as sufficient for the on-line monitoring of the 2 analytes. The present feasibility study confirmed the possibility to use on-line NIR spectroscopy as a PAT tool to monitor in real-time both the API and the residual methanol contents, in order to control the seeding of an API crystallization at industrial scale. Furthermore, the successful scale-up of the method proved its capability to be

  11. Advanced reach tool (ART) : Development of the mechanistic model

    NARCIS (Netherlands)

    Fransman, W.; Tongeren, M. van; Cherrie, J.W.; Tischer, M.; Schneider, T.; Schinkel, J.; Kromhout, H.; Warren, N.; Goede, H.; Tielemans, E.

    2011-01-01

    This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe.

  12. Development of a piano learning tool

    OpenAIRE

    Baloh, Matevž

    2012-01-01

    This thesis analyzes the appropriateness of the formula defined by the game 'Guitar Hero' in an application, which aims to help it's users learn how to play the piano. The appropriateness is determined through the development of an application. The thesis describes an attempt at the development of a game, the primary intention of which is to be fun, with the secondary purpose of teaching how to play the piano. After this, it describes an attempt at the development of an application, the p...

  13. Development of an attrition risk prediction tool.

    Science.gov (United States)

    Fowler, John; Norrie, Peter

    To review lecturers' and students' perceptions of the factors that may lead to attrition from pre-registration nursing and midwifery programmes and to identify ways to reduce the impact of such factors on the student's experience. Comparable attrition rates for nursing and midwifery students across various universities are difficult to monitor accurately; however, estimates that there is approximately a 25% national attrition rate are not uncommon. The financial and human implications of this are significant and worthy of investigation. A study was carried out in one medium-sized UK school of nursing and midwifery, aimed at identifying perceived factors associated with attrition and retention. Thirty-five lecturers were interviewed individually; 605 students completed a questionnaire, and of these, 10 were individually interviewed. Attrition data kept by the student service department were reviewed. Data were collected over an 18-month period in 2007-2008. Regression analysis of the student data identified eight significant predictors. Four of these were 'positive' factors in that they aided student retention and four were 'negative' in that they were associated with students' thoughts of resigning. Student attrition and retention is multifactorial, and, as such, needs to be managed holistically. One aspect of this management could be an attrition risk prediction tool.

  14. Advanced organic analysis and analytical methods development: FY 1995 progress report. Waste Tank Organic Safety Program

    International Nuclear Information System (INIS)

    Wahl, K.L.; Campbell, J.A.; Clauss, S.A.

    1995-09-01

    This report describes the work performed during FY 1995 by Pacific Northwest Laboratory in developing and optimizing analysis techniques for identifying organics present in Hanford waste tanks. The main focus was to provide a means for rapidly obtaining the most useful information concerning the organics present in tank waste, with minimal sample handling and with minimal waste generation. One major focus has been to optimize analytical methods for organic speciation. Select methods, such as atmospheric pressure chemical ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry, were developed to increase the speciation capabilities, while minimizing sample handling. A capillary electrophoresis method was developed to improve separation capabilities while minimizing additional waste generation. In addition, considerable emphasis has been placed on developing a rapid screening tool, based on Raman and infrared spectroscopy, for determining organic functional group content when complete organic speciation is not required. This capability would allow for a cost-effective means to screen the waste tanks to identify tanks that require more specialized and complete organic speciation to determine tank safety

  15. DEVELOPING A TOOL FOR ENVIRONMENTALLY PREFERABLE PURCHASING

    Science.gov (United States)

    LCA-based guidance was developed by EPA under the Framework for Responsible Environmental Decision Making (FRED) effort to demonstrate how to conduct a relative comparison between product types to determine environmental preferability. It identifies data collection needs and iss...

  16. Design and development of progressive tool for manufacturing washer

    Science.gov (United States)

    Annigeri, Ulhas K.; Raghavendra Ravi Kiran, K.; Deepthi, Y. P.

    2017-07-01

    In a progressive tool the raw material is worked at different station to finally fabricate the component. A progressive tool is a lucrative tool for mass production of components. A lot of automobile and other transport industries develop progressive tool for the production of components. The design of tool involves lot of planning and the same amount of skill of process planning is required in the fabrication of the tool. The design also involves use of thumb rules and standard elements as per experience gained in practice. Manufacturing the press tool is a laborious task as special jigs and fixtures have to be designed for the purpose. Assembly of all the press tool elements is another task where use of accurate measuring instruments for alignment of various tool elements is important. In the present study, design and fabrication of progressive press tool for production of washer has been developed and the press tool has been tried out on a mechanical type of press. The components produced are to dimensions.

  17. Development of a tool for evaluating multimedia for surgical education.

    Science.gov (United States)

    Coughlan, Jane; Morar, Sonali S

    2008-09-01

    Educational multimedia has been designed to provide surgical trainees with expert operative information outside of the operating theater. The effectiveness of multimedia (e.g., CD-ROMs) for learning has been a common research topic since the 1990s. To date, however, little discussion has taken place on the mechanisms to evaluate the quality of multimedia-driven teaching. This may be because of a lack of research into the development of appropriate tools for evaluating multimedia, especially for surgical education. This paper reports on a small-scale pilot and exploratory study (n = 12) that developed a tool for surgical multimedia evaluation. The validity of the developed tool was established through adaptation of an existing tool, which was reviewed using experts in surgery, usability, and education. The reliability of the developed tool was tested with surgical trainees who used it to assess a multimedia CD-ROM created for teaching basic surgical skills. The findings contribute to an understanding of surgical trainees' experience of using educational multimedia, in terms of characteristics of the learning material for interface design and content and the process of developing evaluation tools, in terms of inclusion of appropriate assessment criteria. The increasing use of multimedia in medical education necessitates the development of standardized tools for determining the quality of teaching and learning. Little research exists into the development of such tools and so the present work stimulates discussion on how to evaluate surgical training.

  18. Development and Validation of a Learning Analytics Framework: Two Case Studies Using Support Vector Machines

    Science.gov (United States)

    Ifenthaler, Dirk; Widanapathirana, Chathuranga

    2014-01-01

    Interest in collecting and mining large sets of educational data on student background and performance to conduct research on learning and instruction has developed as an area generally referred to as learning analytics. Higher education leaders are recognizing the value of learning analytics for improving not only learning and teaching but also…

  19. The use of selective adsorbents in capillary electrophoresis-mass spectrometry for analyte preconcentration and microreactions: a powerful three-dimensional tool for multiple chemical and biological applications.

    Science.gov (United States)

    Guzman, N A; Stubbs, R J

    2001-10-01

    Much attention has recently been directed to the development and application of online sample preconcentration and microreactions in capillary electrophoresis using selective adsorbents based on chemical or biological specificity. The basic principle involves two interacting chemical or biological systems with high selectivity and affinity for each other. These molecular interactions in nature usually involve noncovalent and reversible chemical processes. Properly bound to a solid support, an "affinity ligand" can selectively adsorb a "target analyte" found in a simple or complex mixture at a wide range of concentrations. As a result, the isolated analyte is enriched and highly purified. When this affinity technique, allowing noncovalent chemical interactions and biochemical reactions to occur, is coupled on-line to high-resolution capillary electrophoresis and mass spectrometry, a powerful tool of chemical and biological information is created. This paper describes the concept of biological recognition and affinity interaction on-line with high-resolution separation, the fabrication of an "analyte concentrator-microreactor", optimization conditions of adsorption and desorption, the coupling to mass spectrometry, and various applications of clinical and pharmaceutical interest.

  20. An analytical method on the surface residual stress for the cutting tool orientation

    Science.gov (United States)

    Li, Yueen; Zhao, Jun; Wang, Wei

    2010-03-01

    The residual stress is measured by choosing 8 kinds orientations on cutting the H13 dies steel on the HSM in the experiment of this paper. The measured data shows on that the residual stress exists periodicity for the different rake angle (β) and side rake angle (θ) parameters, further study find that the cutting tool orientations have closed relationship with the residual stresses, and for the original of the machined residual stress on the surface from the cutting force and the axial force, it can be gained the simply model of tool-workpiece force, using the model it can be deduced the residual stress model, which is feasible to calculate the size of residual stress. And for almost all the measured residual stresses are compressed stress, the compressed stress size and the direction could be confirmed by the input data for the H13 on HSM. As the result, the residual stress model is the key for optimization of rake angle (β) and side rake angle (θ) in theory, using the theory the more cutting mechanism can be expressed.

  1. Thermal Lens Spectroscopy as a 'new' analytical tool for actinide determination in nuclear reprocessing processes

    International Nuclear Information System (INIS)

    Canto, Fabrice; Couston, Laurent; Magnaldo, Alastair; Broquin, Jean-Emmanuel; Signoret, Philippe

    2008-01-01

    Thermal Lens Spectroscopy (TLS) consists of measuring the effects induced by the relaxation of molecules excited by photons. Twenty years ago, the Cea already worked on TLS. Technologic reasons impeded. But, needs in sensitive analytical methods coupled with very low sample volumes (for example, traces of Np in the COEX TM process) and also the reduction of the nuclear wastes encourage us to revisit this method thanks to the improvement of optoelectronic technologies. We can also imagine coupling TLS with micro-fluidic technologies, decreasing significantly the experiments cost. Generally two laser beams are used for TLS: one for the selective excitation by molecular absorption (inducing the thermal lens) and one for probing the thermal lens. They can be coupled with different geometries, collinear or perpendicular, depending on the application and on the laser mode. Also, many possibilities of measurement have been studied to detect the thermal lens signal: interferometry, direct intensities variations, deflection etc... In this paper, one geometrical configuration and two measurements have been theoretically evaluated. For a single photodiode detection (z-scan) the limit of detection is calculated to be near 5*10 -6 mol*L -1 for Np(IV) in dodecane. (authors)

  2. External beam milli-PIXE as analytical tool for Neolithic obsidian provenance studies

    Energy Technology Data Exchange (ETDEWEB)

    Constantinescu, B.; Cristea-Stan, D. [National Institute for Nuclear Physics and Engineering Horia Hulubei, Bucharest-Magurele (Romania); Kovács, I.; Szõkefalvi-Nagy, Z. [Wigner Research Centre for Phyics, Institute for Particle and Nuclear Physics, Budapest (Hungary)

    2013-07-01

    Full text: Obsidian is the most important archaeological material used for tools and weapons before metals appearance. Its geological sources are limited and concentrated in few geographical zones: Armenia, Eastern Anatolia, Italian Lipari and Sardinia islands, Greek Melos and Yali islands, Hungarian and Slovak Tokaj Mountains. Due to this fact, in Mesolithic and Neolithic periods obsidian was the first archaeological material intensively traded even at long distances. To determine the geological provenance of obsidian and to identify the prehistoric long-range trade routes and possible population migrations elemental concentration ratios can help a 101, since each geological source has its 'fingerprints'. In this work external milli-PIXE technique was applied for elemental concentration ratio determinations in some Neolithic tools found in Transylvania and in the lron Gales region near Danube, and on few relevant geological samples (Slovak Tokaj Mountains, Lipari,Armenia). In Transylvania (the North-Western part of Romania, a region surrounded by Carpathian Mountains), Neolithic obsidian tools were discovered mainly in three regions: North-West - Oradea (near the border with Hungary, Slovakia and Ukraine), Centre -Cluj and Southwest- Banat (near the border with Serbia). A special case is lron Gales - Mesolithic and Early Neolithic sites, directly related to the appearance of agriculture replacing the Mesolithic economy based on hunting and fishing. Three long-distance trade routes could be considered: from Caucasus Mountains via North of the Black Sea, from Greek islands or Asia Minor via ex-Yugoslavia area or via Greece-Bulgaria or from Central Europe- Tokaj Mountains in the case of obsidian. As provenance 'fingerprints', we focused on Ti to Mn, and Rb-Sr-Y-Zr ratios. The measurements were performed at the external milli-PIXE beam-line of the 5MV VdG accelerator of the Wigner RCP. Proton energy of 3MeV and beam currents in the range of 1 ±1 D

  3. External beam milli-PIXE as analytical tool for Neolithic obsidian provenance studies

    International Nuclear Information System (INIS)

    Constantinescu, B.; Cristea-Stan, D.; Kovács, I.; Szõkefalvi-Nagy, Z.

    2013-01-01

    Full text: Obsidian is the most important archaeological material used for tools and weapons before metals appearance. Its geological sources are limited and concentrated in few geographical zones: Armenia, Eastern Anatolia, Italian Lipari and Sardinia islands, Greek Melos and Yali islands, Hungarian and Slovak Tokaj Mountains. Due to this fact, in Mesolithic and Neolithic periods obsidian was the first archaeological material intensively traded even at long distances. To determine the geological provenance of obsidian and to identify the prehistoric long-range trade routes and possible population migrations elemental concentration ratios can help a 101, since each geological source has its 'fingerprints'. In this work external milli-PIXE technique was applied for elemental concentration ratio determinations in some Neolithic tools found in Transylvania and in the lron Gales region near Danube, and on few relevant geological samples (Slovak Tokaj Mountains, Lipari,Armenia). In Transylvania (the North-Western part of Romania, a region surrounded by Carpathian Mountains), Neolithic obsidian tools were discovered mainly in three regions: North-West - Oradea (near the border with Hungary, Slovakia and Ukraine), Centre -Cluj and Southwest- Banat (near the border with Serbia). A special case is lron Gales - Mesolithic and Early Neolithic sites, directly related to the appearance of agriculture replacing the Mesolithic economy based on hunting and fishing. Three long-distance trade routes could be considered: from Caucasus Mountains via North of the Black Sea, from Greek islands or Asia Minor via ex-Yugoslavia area or via Greece-Bulgaria or from Central Europe- Tokaj Mountains in the case of obsidian. As provenance 'fingerprints', we focused on Ti to Mn, and Rb-Sr-Y-Zr ratios. The measurements were performed at the external milli-PIXE beam-line of the 5MV VdG accelerator of the Wigner RCP. Proton energy of 3MeV and beam currents in the range of 1 ±1 D

  4. Developing a 300C Analog Tool for EGS

    Energy Technology Data Exchange (ETDEWEB)

    Normann, Randy

    2015-03-23

    This paper covers the development of a 300°C geothermal well monitoring tool for supporting future EGS (enhanced geothermal systems) power production. This is the first of 3 tools planed. This is an analog tool designed for monitoring well pressure and temperature. There is discussion on 3 different circuit topologies and the development of the supporting surface electronics and software. There is information on testing electronic circuits and component. One of the major components is the cable used to connect the analog tool to the surface.

  5. A PSYCHOSOCIAL TOOL FOR CHILD'S DEVELOPMENT Nicholas

    African Journals Online (AJOL)

    They are often burdened with exceedingly great parental expectations particularly ... the life span, Smarts sees human development as: The scientific .... existence which is balance, speed and coordination. Dance: A ... In every work of art especially dance, what makes it more effective is .... The Benefits of Dance. Owerri: Ata ...

  6. Tools for Nanotechnology Education Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Dorothy Moore

    2010-09-27

    The overall focus of this project was the development of reusable, cost-effective educational modules for use with the table top scanning electron microscope (TTSEM). The goal of this project's outreach component was to increase students' exposure to the science and technology of nanoscience.

  7. Developing tools to sustain biological diversity.

    Science.gov (United States)

    Randy. Molina

    2004-01-01

    The Biodiversity Initiative strives to provide innovative solutions to the complex problem of managing forests for biodiversity. Although this initiative is in its beginning stages, an initial scoping meeting has already taken place and planning for the next steps is underway. The initiative is developing plans to conduct extensive scoping efforts in the management,...

  8. An analytical tool to support the pedestrianisation process: The case of via Roma, Cagliari

    Directory of Open Access Journals (Sweden)

    Alfonso Annunziata

    2018-04-01

    Full Text Available The article focuses on the case of the modification of an urban road network: the transformation of a portion of an important distributor road in the urban area of Cagliari into a pedestrian space. By means of this case study the article aims to point out how pedestrianisation interventions have not been completely defined within a theoretical system that clearly establishes modes and conditions of implementation. This lack of theorization has led to the common understanding of pedestrianisation as good operations in and of itself and, as such, exportable, meant to produce the same effects everywhere (Bianchetti, 2016. This analysis uses the fundamental conditions of hierarchy as a tool to assess to what extent the modification of the road network articulation has resulted in conditions of lesser inter-connectivity, legibility and functionality. In this perspective the article proposes a system of criteria, founded on the principles of hierarchy, meant to be a theoretical support for processes of pedestrianisation.

  9. Puzzle test: A tool for non-analytical clinical reasoning assessment.

    Science.gov (United States)

    Monajemi, Alireza; Yaghmaei, Minoo

    2016-01-01

    Most contemporary clinical reasoning tests typically assess non-automatic thinking. Therefore, a test is needed to measure automatic reasoning or pattern recognition, which has been largely neglected in clinical reasoning tests. The Puzzle Test (PT) is dedicated to assess automatic clinical reasoning in routine situations. This test has been introduced first in 2009 by Monajemi et al in the Olympiad for Medical Sciences Students.PT is an item format that has gained acceptance in medical education, but no detailed guidelines exist for this test's format, construction and scoring. In this article, a format is described and the steps to prepare and administer valid and reliable PTs are presented. PT examines a specific clinical reasoning task: Pattern recognition. PT does not replace other clinical reasoning assessment tools. However, it complements them in strategies for assessing comprehensive clinical reasoning.

  10. 105-KE Basin isolation barrier leak rate test analytical development. Revision 1

    International Nuclear Information System (INIS)

    Irwin, J.J.

    1995-01-01

    This document provides an analytical development in support of the proposed leak rate test of the 105-KE Basin. The analytical basis upon which the K-basin leak test results will be used to determine the basin leakage rates is developed in this report. The leakage of the K-Basin isolation barriers under postulated accident conditions will be determined from the test results. There are two fundamental flow regimes that may exist in the postulated K-Basin leakage: viscous laminar and turbulent flow. An analytical development is presented for each flow regime. The basic geometry and nomenclature of the postulated leak paths are denoted

  11. 78 FR 68459 - Medical Device Development Tools; Draft Guidance for Industry, Tool Developers, and Food and Drug...

    Science.gov (United States)

    2013-11-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-D-1279] Medical Device Development Tools; Draft Guidance for Industry, Tool Developers, and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

  12. EXPERT SYSTEMS - DEVELOPMENT OF AGRICULTURAL INSURANCE TOOL

    Directory of Open Access Journals (Sweden)

    NAN Anca-Petruţa

    2013-07-01

    Full Text Available Because of the fact that specialty agricultural assistance is not always available when the farmers need it, we identified expert systems as a strong instrument with an extended potential in agriculture. This started to grow in scale recently, including all socially-economic activity fields, having the role of collecting data regarding different aspects from human experts with the purpose of assisting the user in the necessary steps for solving problems, at the performance level of the expert, making his acquired knowledge and experience available. We opted for a general presentation of the expert systems as well as their necessity, because, the solution to develop the agricultural system can come from artificial intelligence by implementing the expert systems in the field of agricultural insurance, promoting existing insurance products, farmers finding options in depending on their necessities and possibilities. The objective of this article consists of collecting data about different aspects about specific areas of interest of agricultural insurance, preparing the database, a conceptual presentation of a pilot version which will become constantly richer depending on the answers received from agricultural producers, with the clearest exposure of knowledgebase possible. We can justify picking this theme with the fact that even while agricultural insurance plays a very important role in agricultural development, the registered result got from them are modest, reason why solutions need to be found in the scope of developing the agricultural sector. The importance of this consists in the proposal of an immediate viable solution to correspond with the current necessities of agricultural producers and in the proposal of an innovative solution, namely the implementation of expert system in agricultural insurance as a way of promoting insurance products. Our research, even though it treats the subject at an conceptual level, it wants to undertake an

  13. Libraries Are Dynamic Tools for National Development

    Directory of Open Access Journals (Sweden)

    Amaoge Dorathy Agbo

    2014-12-01

    Full Text Available Building an ideal nation requires a holistic approach. All facets of human activity must be harnessed while all indices of nation building must be taken care of. In doing this, all academic and professional disciplines are involved. Libraries are not exception. This paper looks at various types of libraries and their basic functions, their roles in national development, and in particular, the challenges facing library services in Nigeria, such as inadequately trained staff to meet the increasing demands of users.

  14. VisTool: A user interface and visualization development system

    DEFF Research Database (Denmark)

    Xu, Shangjin

    system – to simplify user interface development. VisTool allows user interface development without real programming. With VisTool a designer assembles visual objects (e.g. textboxes, ellipse, etc.) to visualize database contents. In VisTool, visual properties (e.g. color, position, etc.) can be formulas...... programming. However, in Software Engineering, software engineers who develop user interfaces do not follow it. In many cases, it is desirable to use graphical presentations, because a graphical presentation gives a better overview than text forms, and can improve task efficiency and user satisfaction....... However, it is more difficult to follow the classical usability approach for graphical presentation development. These difficulties result from the fact that designers cannot implement user interface with interactions and real data. We developed VisTool – a user interface and visualization development...

  15. Seductive Atmospheres: Using tools to effectuate spaces for Leadership Development

    DEFF Research Database (Denmark)

    Elmholdt, Kasper Trolle; Clausen, Rune Thorbjørn; Madsen, Mona T

    2018-01-01

    Hospital, this study investigates how a business game is used as a tool to effectuate episodic spaces for leadership development. The study reveals three tool affordances and discusses how they enable and constrain episodic spaces for development and further develops the notion of seductive atmospheres......This study applies an affordance lens to understand the use of management tools and how atmospheres for change and development are created and exploited. Drawing on an ethnographic case study of a consultant-facilitated change intervention among a group of research leaders at a Danish Public...... as an important mechanism. The article suggests that a broader understanding of the use of tools and the role of atmospheres is essential for understanding how episodic spaces for development come to work in relation to organizational change and development....

  16. An Analytic Framework to Support E.Learning Strategy Development

    Science.gov (United States)

    Marshall, Stephen J.

    2012-01-01

    Purpose: The purpose of this paper is to discuss and demonstrate the relevance of a new conceptual framework for leading and managing the development of learning and teaching to e.learning strategy development. Design/methodology/approach: After reviewing and discussing the research literature on e.learning in higher education institutions from…

  17. Supporting medical technology development with the analytic hierarchy process

    NARCIS (Netherlands)

    Hummel, Janna Marchien

    2001-01-01

    This thesis aims to develop an adequate method of CTA to influence decision making about the development and clinical application of a medical technology. The adequacy of this method is related to the timing of its application, the information used in the assessment, the consensus formation about,

  18. Developing an Analytical Framework for Argumentation on Energy Consumption Issues

    Science.gov (United States)

    Jin, Hui; Mehl, Cathy E.; Lan, Deborah H.

    2015-01-01

    In this study, we aimed to develop a framework for analyzing the argumentation practice of high school students and high school graduates. We developed the framework in a specific context--how energy consumption activities such as changing diet, converting forests into farmlands, and choosing transportation modes affect the carbon cycle. The…

  19. Software Development Methods and Tools: a New Zealand study

    OpenAIRE

    Chris Phillips; Elizabeth Kemp; Duncan Hedderley

    2005-01-01

    This study is a more detailed follow-up to a preliminary investigation of the practices of software engineers in New Zealand. The focus of this study is on the methods and tools used by software developers in their current organisation. The project involved detailed questionnaires being piloted and sent out to several hundred software developers. A central part of the research involved the identification of factors affecting the use and take-up of existing software development tools in the wo...

  20. The development of tool manufacture in humans: what helps young children make innovative tools?

    Science.gov (United States)

    Chappell, Jackie; Cutting, Nicola; Apperly, Ian A; Beck, Sarah R

    2013-11-19

    We know that even young children are proficient tool users, but until recently, little was known about how they make tools. Here, we will explore the concepts underlying tool making, and the kinds of information and putative cognitive abilities required for children to manufacture novel tools. We will review the evidence for novel tool manufacture from the comparative literature and present a growing body of data from children suggesting that innovation of the solution to a problem by making a tool is a much more challenging task than previously thought. Children's difficulty with these kinds of tasks does not seem to be explained by perseveration with unmodified tools, difficulty with switching to alternative strategies, task pragmatics or issues with permission. Rather, making novel tools (without having seen an example of the required tool within the context of the task) appears to be hard, because it is an example of an 'ill-structured problem'. In this type of ill-structured problem, the starting conditions and end goal are known, but the transformations and/or actions required to get from one to the other are not specified. We will discuss the implications of these findings for understanding the development of problem-solving in humans and other animals.

  1. The development of tool manufacture in humans: what helps young children make innovative tools?

    Science.gov (United States)

    Chappell, Jackie; Cutting, Nicola; Apperly, Ian A.; Beck, Sarah R.

    2013-01-01

    We know that even young children are proficient tool users, but until recently, little was known about how they make tools. Here, we will explore the concepts underlying tool making, and the kinds of information and putative cognitive abilities required for children to manufacture novel tools. We will review the evidence for novel tool manufacture from the comparative literature and present a growing body of data from children suggesting that innovation of the solution to a problem by making a tool is a much more challenging task than previously thought. Children's difficulty with these kinds of tasks does not seem to be explained by perseveration with unmodified tools, difficulty with switching to alternative strategies, task pragmatics or issues with permission. Rather, making novel tools (without having seen an example of the required tool within the context of the task) appears to be hard, because it is an example of an ‘ill-structured problem’. In this type of ill-structured problem, the starting conditions and end goal are known, but the transformations and/or actions required to get from one to the other are not specified. We will discuss the implications of these findings for understanding the development of problem-solving in humans and other animals. PMID:24101620

  2. Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis.

    Science.gov (United States)

    Du, Yong; Fu, Yuyang; Mohan, Chandra

    2008-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease that results in immune-mediated damage to multiple organs. Among these, kidney involvement is the most common and fatal. Spontaneous lupus nephritis (SLN) in mouse models has provided valuable insights into the underlying mechanisms of human lupus nephritis. However, SLN in mouse models takes 6-12 months to manifest; hence there is clearly the need for a mouse model that can be used to unveil the pathogenic processes that lead to immune nephritis over a shorter time frame. In this article more than 25 different molecules are reviewed that have been studied both in the anti-glomerular basement membrane (anti-GBM) model and in SLN and it was found that these molecules influence both diseases in a parallel fashion, suggesting that the two disease settings share common molecular mechanisms. Based on these observations, the authors believe the experimental anti-GBM disease model might be one of the best tools currently available for uncovering the downstream molecular mechanisms leading to SLN.

  3. DR-Integrator: a new analytic tool for integrating DNA copy number and gene expression data.

    Science.gov (United States)

    Salari, Keyan; Tibshirani, Robert; Pollack, Jonathan R

    2010-02-01

    DNA copy number alterations (CNA) frequently underlie gene expression changes by increasing or decreasing gene dosage. However, only a subset of genes with altered dosage exhibit concordant changes in gene expression. This subset is likely to be enriched for oncogenes and tumor suppressor genes, and can be identified by integrating these two layers of genome-scale data. We introduce DNA/RNA-Integrator (DR-Integrator), a statistical software tool to perform integrative analyses on paired DNA copy number and gene expression data. DR-Integrator identifies genes with significant correlations between DNA copy number and gene expression, and implements a supervised analysis that captures genes with significant alterations in both DNA copy number and gene expression between two sample classes. DR-Integrator is freely available for non-commercial use from the Pollack Lab at http://pollacklab.stanford.edu/ and can be downloaded as a plug-in application to Microsoft Excel and as a package for the R statistical computing environment. The R package is available under the name 'DRI' at http://cran.r-project.org/. An example analysis using DR-Integrator is included as supplemental material. Supplementary data are available at Bioinformatics online.

  4. Demonstration of FBRM as process analytical technology tool for dewatering processes via CST correlation.

    Science.gov (United States)

    Cobbledick, Jeffrey; Nguyen, Alexander; Latulippe, David R

    2014-07-01

    The current challenges associated with the design and operation of net-energy positive wastewater treatment plants demand sophisticated approaches for the monitoring of polymer-induced flocculation. In anaerobic digestion (AD) processes, the dewaterability of the sludge is typically assessed from off-line lab-bench tests - the capillary suction time (CST) test is one of the most common. Focused beam reflectance measurement (FBRM) is a promising technique for real-time monitoring of critical performance attributes in large scale processes and is ideally suited for dewatering applications. The flocculation performance of twenty-four cationic polymers, that spanned a range of polymer size and charge properties, was measured using both the FBRM and CST tests. Analysis of the data revealed a decreasing monotonic trend; the samples that had the highest percent removal of particles less than 50 microns in size as determined by FBRM had the lowest CST values. A subset of the best performing polymers was used to evaluate the effects of dosage amount and digestate sources on dewatering performance. The results from this work show that FBRM is a powerful tool that can be used for optimization and on-line monitoring of dewatering processes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Analytical tool for the periodic safety analysis of NPP according to the PSA guideline. Vol. 1

    International Nuclear Information System (INIS)

    Balfanz, H.P.; Boehme, E.; Musekamp, W.; Hussels, U.; Becker, G.; Behr, H.; Luettgert, H.

    1994-01-01

    The SAIS (Safety Analysis and Informationssystem) Programme System is based on an integrated data base, which consists of a plant-data and a PSA related data part. Using SAIS analyses can be performed by special tools, which are connected directly to the data base. Two main editors, RISA+ and DEDIT, are used for data base management. The access to the data base is done via different types of pages, which are displayed on a displayed on a computer screen. The pages are called data sheets. Sets of input and output data sheets were implemented, such as system or component data sheets, fault trees or event trees. All input information, models and results needed for updated results of PSA (Living PSA) can be stored in the SAIS. The programme system contains the editor KVIEW which guarantees consistency of the stored data, e.g. with respect to names and codes of components and events. The information contained in the data base are called in by a standardized users guide programme, called Page Editor. (Brunsbuettel on reference NPP). (orig./HP) [de

  6. Development of a core management tool for MYRRHA

    International Nuclear Information System (INIS)

    Jalůvka, David; Van den Eynde, Gert; Vandewalle, Stefan

    2013-01-01

    Highlights: • An in-core fuel management tool is being developed for the flexible irradiation machine MYRRHA. • Specific issues of the MYRRHA in-core fuel management are briefly discussed. • The tool addresses the loading pattern optimization problem. • Illustrative in-core fuel management optimization problems are solved using the tool. - Abstract: MYRRHA is an advanced multi-purpose irradiation facility under development at SCK• CEN in Mol, Belgium. In order to ensure an economical and safe operation of the reactor, an in-core fuel management tool is being developed within the project to address the loading pattern optimization problem. In the paper, the current version of the tool – its architecture and design, unique features, and the field of its application, are presented. In the second part of the paper, the tool’s capabilities are demonstrated on simple MYRRHA in-core fuel management optimization problems

  7. Software Development Methods and Tools: a New Zealand study

    Directory of Open Access Journals (Sweden)

    Chris Phillips

    2005-05-01

    Full Text Available This study is a more detailed follow-up to a preliminary investigation of the practices of software engineers in New Zealand. The focus of this study is on the methods and tools used by software developers in their current organisation. The project involved detailed questionnaires being piloted and sent out to several hundred software developers. A central part of the research involved the identification of factors affecting the use and take-up of existing software development tools in the workplace. The full spectrum of tools from fully integrated I-CASE tools to individual software applications, such as drawing tools was investigated. This paper describes the project and presents the findings.

  8. Photography by Cameras Integrated in Smartphones as a Tool for Analytical Chemistry Represented by an Butyrylcholinesterase Activity Assay.

    Science.gov (United States)

    Pohanka, Miroslav

    2015-06-11

    Smartphones are popular devices frequently equipped with sensitive sensors and great computational ability. Despite the widespread availability of smartphones, practical uses in analytical chemistry are limited, though some papers have proposed promising applications. In the present paper, a smartphone is used as a tool for the determination of cholinesterasemia i.e., the determination of a biochemical marker butyrylcholinesterase (BChE). The work should demonstrate suitability of a smartphone-integrated camera for analytical purposes. Paper strips soaked with indoxylacetate were used for the determination of BChE activity, while the standard Ellman's assay was used as a reference measurement. In the smartphone-based assay, BChE converted indoxylacetate to indigo blue and coloration was photographed using the phone's integrated camera. A RGB color model was analyzed and color values for the individual color channels were determined. The assay was verified using plasma samples and samples containing pure BChE, and validated using Ellmans's assay. The smartphone assay was proved to be reliable and applicable for routine diagnoses where BChE serves as a marker (liver function tests; some poisonings, etc.). It can be concluded that the assay is expected to be of practical applicability because of the results' relevance.

  9. Photography by Cameras Integrated in Smartphones as a Tool for Analytical Chemistry Represented by an Butyrylcholinesterase Activity Assay

    Directory of Open Access Journals (Sweden)

    Miroslav Pohanka

    2015-06-01

    Full Text Available Smartphones are popular devices frequently equipped with sensitive sensors and great computational ability. Despite the widespread availability of smartphones, practical uses in analytical chemistry are limited, though some papers have proposed promising applications. In the present paper, a smartphone is used as a tool for the determination of cholinesterasemia i.e., the determination of a biochemical marker butyrylcholinesterase (BChE. The work should demonstrate suitability of a smartphone-integrated camera for analytical purposes. Paper strips soaked with indoxylacetate were used for the determination of BChE activity, while the standard Ellman’s assay was used as a reference measurement. In the smartphone-based assay, BChE converted indoxylacetate to indigo blue and coloration was photographed using the phone’s integrated camera. A RGB color model was analyzed and color values for the individual color channels were determined. The assay was verified using plasma samples and samples containing pure BChE, and validated using Ellmans’s assay. The smartphone assay was proved to be reliable and applicable for routine diagnoses where BChE serves as a marker (liver function tests; some poisonings, etc.. It can be concluded that the assay is expected to be of practical applicability because of the results’ relevance.

  10. Towards a green analytical laboratory: microextraction techniques as a useful tool for the monitoring of polluted soils

    Science.gov (United States)

    Lopez-Garcia, Ignacio; Viñas, Pilar; Campillo, Natalia; Hernandez Cordoba, Manuel; Perez Sirvent, Carmen

    2016-04-01

    Microextraction techniques are a valuable tool at the analytical laboratory since they allow sensitive measurements of pollutants to be carried out by means of easily available instrumentation. There is a large number of such procedures involving miniaturized liquid-liquid or liquid-solid extractions with the common denominator of using very low amounts (only a few microliters) or even none of organic solvents. Since minimal amounts of reagents are involved, and the generation of residues is consequently minimized, the approach falls within the concept of Green Analytical Chemistry. This general methodology is useful both for inorganic and organic pollutants. Thus, low amounts of metallic ions can be measured without the need of using ICP-MS since this instrument can be replaced by a simple AAS spectrometer which is commonly present in any laboratory and involves low acquisition and maintenance costs. When dealing with organic pollutants, the microextracts obtained can be introduced into liquid or gas chromatographs equipped with common detectors and there is no need for the most sophisticated and expensive mass spectrometers. This communication reports an overview of the advantages of such a methodology, and gives examples for the determination of some particular contaminants in soil and water samples The authors are grateful to the Comunidad Autonóma de la Región de Murcia , Spain (Fundación Séneca, 19888/GERM/15) for financial support

  11. Evaluation and selection of CASE tool for SMART OTS development

    International Nuclear Information System (INIS)

    Park, K. O; Seo, S. M.; Seo, Y. S.; Koo, I. S.; Jang, M. H.

    1999-01-01

    CASE(Computer-Aided Software Engineering) tool is a software that aids in software engineering activities such as requirement analysis, design, testing, configuration management, and project management. The evaluation and selection of commercial CASE tools for the specific software development project is not a easy work because the technical ability of an evaluator and the maturity of a software development organization are required. In this paper, we discuss selection strategies, characteristic survey, evaluation criteria, and the result of CASE tool selection for the development of SMART(System-integrated Modular Advanced ReacTor) OTS(Operator Training Simulator)

  12. Market research companies and new product development tools

    NARCIS (Netherlands)

    Nijssen, E.J.; Frambach, R.T.

    1998-01-01

    This research investigates (1) the share of new product development (NPD) research services in market research (MR) companies’ turnover, (2) MR companies’ awareness and use of NPD tools and the modifications made to these NPD tools, and (3) MR company managers’ perceptions of the influence of client

  13. Market research companies and new product development tools

    NARCIS (Netherlands)

    Nijssen, Edwin J.; Frambach, Ruud T.

    1998-01-01

    This research investigates (1) the share of new product development (NPD) research services in market research (MR) companies' turnover, (2) MR companies' awareness and use of NPD tools and the modifications made to these NPD tools, and (3) MR company managers' perceptions of the influence of client

  14. Developing Tool Support for Problem Diagrams with CPN and VDM++

    DEFF Research Database (Denmark)

    Tjell, Simon; Lassen, Kristian Bisgaard

    2008-01-01

    In this paper, we describe ongoing work on the development of tool support for formal description of domains found in Problem Diagrams. The purpose of the tool is to handle the generation of a CPN model based on a collection of Problem Diagrams. The Problem Diagrams are used for representing the ...

  15. Developing a verification tool for calculations dissemination through COBAYA

    International Nuclear Information System (INIS)

    Sabater Alcaraz, A.; Rucabado Rucabado, G.; Cuervo Gomez, D.; Garcia Herranz, N.

    2014-01-01

    The development of a software tool that automates the comparison of results with previous versions of the code and results using models of accuracy is crucial for implementing the code new functionalities. The work presented here has been the generation the mentioned tool and the set of reference cases that have set up the afore mentioned matrix. (Author)

  16. Pupils, Tools and the Zone of Proximal Development

    Science.gov (United States)

    Abtahi, Yasmine

    2018-01-01

    In this article, I use the Vygotskian concept of the Zone of Proximal Development (ZPD) to examine the learning experience of two grade seven pupils as they attempted to solve an addition of fractions problem using fraction strips. The aim is to highlight how tools can facilitate the enactment of a ZPD, within which the tool provides the guidance.…

  17. Development of a data capture tool for researching tech entrepreneurship

    DEFF Research Database (Denmark)

    Andersen, Jakob Axel Bejbro; Howard, Thomas J.; McAloone, Tim C.

    2014-01-01

    . This paper elucidates the requirements for such tools by drawing on knowledge of the entrepreneurial phenomenon and by building on the existing research tools used in design research. On this basis, the development of a capture method for tech startup processes is described and its potential discussed....

  18. User Studies: Developing Learning Strategy Tool Software for Children.

    Science.gov (United States)

    Fitzgerald, Gail E.; Koury, Kevin A.; Peng, Hsinyi

    This paper is a report of user studies for developing learning strategy tool software for children. The prototype software demonstrated is designed for children with learning and behavioral disabilities. The tools consist of easy-to-use templates for creating organizational, memory, and learning approach guides for use in classrooms and at home.…

  19. Adverse outcome pathway networks: Development, analytics and applications

    Science.gov (United States)

    The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...

  20. Family Environment and Cognitive Development: Twelve Analytic Models

    Science.gov (United States)

    Walberg, Herbert J.; Marjoribanks, Kevin

    1976-01-01

    The review indicates that refined measures of the family environment and the use of complex statistical models increase the understanding of the relationships between socioeconomic status, sibling variables, family environment, and cognitive development. (RC)

  1. Development of Analytical Method for Detection of Some ...

    African Journals Online (AJOL)

    All rights reserved. ... 3Centre for Water Research and Analysis (ALIR), Faculty of Science and Technology, Universiti Kebangsaan (UKM), ... Purpose: To develop and validate a simple method using solid – phase extraction along with liquid.

  2. Development of analytical techniques in support of waste and effluent characterization

    International Nuclear Information System (INIS)

    Reed, W.J.

    1991-01-01

    The Analytical Services Group within Sellafield Technical Department has been established for >40 yr and employs >150 analysts. The group operates >400 analytical methods across a wide range of techniques and has a yearly workload of ∼250,000 determinations. The group operates under a quality system based on statistical process control that has achieved national recognition through the accreditation of its mass spectrometry and radiochemical services to the standard of national testing laboratories. The group offers services ranging from the characterization of highly active wastes to trace elemental and radiochemical measurements in environmental, biological, and effluent streams. The group has vast experience in the management of analytical services to tight time scales and has pioneered developments not only in analytical instrumentation, but also in the adaptation of equipment to radioactive environments and the design of dedicated analytical facilities

  3. Designing a tool for curriculum leadership development in postgraduate programs

    Directory of Open Access Journals (Sweden)

    M Avizhgan

    2016-07-01

    Full Text Available Introduction: Leadership in the area of curriculum development is increasingly important as we look for ways to improve our programmes and practices. In curriculum studies, leadership has received little attention. Considering the lack of an evaluation tool with objective criteria in postgraduate curriculum leadership process, this study aimed to design a specific tool and determine the validity and reliability of the tool. Method: This study is a methodological research.  At first, domains and items of the tool were determined through expert interviews and literature review. Then, using Delphi technique, 54 important criteria were developed. A panel of experts was used to confirm content and face validity. Reliability was determined by a descriptive study in which 30 faculties from two of Isfahan universities and was estimated by internal consistency. The data were analyzed by SPSS software, using Pearson Correlation Coefficient and reliability analysis. Results: At first, considering the definition of curriculum leadership determined the domains and items of the tool and they were developed primary tool. Expert’s faculties’ views were used in deferent stages of development and psychometry. The tool internal consistency with Cronbach's alpha coefficient times was 96.5. This was determined for each domain separately. Conclution: Applying this instrument can improve the effectiveness of curriculum leadership. Identifying the characteristics of successful and effective leaders, and utilizing this knowledge in developing and implementing curriculum might help us to have better respond to the changing needs of our students, teachers and schools of tomorrow.

  4. Development of tools for optimization of HWC

    International Nuclear Information System (INIS)

    Wikmark, Gunnar; Lundgren, Klas; Wijkstroem, Hjalmar; Pein, Katarina; Ullberg, Mats

    2004-06-01

    An ECP model for the Swedish Boiling Water Reactors (BWRs) was developed in a previous project sponsored by the Swedish Nuclear Power Inspectorate. The present work is an extension of that effort. The model work has been extended in three ways. Some potential problem areas of the ECP sub-model have been treated in full detail. A comprehensive calibration data set has been assembled from plant data and from laboratory and in-plant experiments. The model has been fitted to the calibration data set and the model parameters adjusted. The work on the ECP sub-model has demonstrated that the generalised Butler Volmer equation, as previously used, adequately describes the electrochemistry. Thus, there is no need to treat the system surface oxides as semiconductors or to take double layer effects into account. The existence of a pseudo potential for the reaction of oxygen on stainless steel is confirmed. The concentration dependence and temperature dependence of the exchange current densities are still unclear. An experimental investigation of these is therefore desirable. An interesting alternative to a conventional experimental set-up is to combine modelling with simpler and more easily controlled experiments. In addition to a calibration data set, the survey of plant data has also led to an improved understanding of the necessary parameters of an ECP model. Thus, variations of the H 2 injection rate at constant reactor power level and constant recirculation flow rate were traced to variations of the relative power level of the fuel elements in the core periphery. The power level in the core periphery determines the dose rate in the down comer and controls the recombination reaction that is fundamental to Hydrogen Water Chemistry (HWC). To accurately model ECP as a function of hydrogen injection rate and other plant parameters, the relative power level of the core periphery is a necessary model parameter that has to be regularly updated from core management codes

  5. BAC-Dkk3-EGFP Transgenic Mouse: An In Vivo Analytical Tool for Dkk3 Expression

    Directory of Open Access Journals (Sweden)

    Yuki Muranishi

    2012-01-01

    Full Text Available Dickkopf (DKK family proteins are secreted modulators of the Wnt signaling pathway and are capable of regulating the development of many organs and tissues. We previously identified Dkk3 to be a molecule predominantly expressed in the mouse embryonic retina. However, which cell expresses Dkk3 in the developing and mature mouse retina remains to be elucidated. To examine the precise expression of the Dkk3 protein, we generated BAC-Dkk3-EGFP transgenic mice that express EGFP integrated into the Dkk3 gene in a BAC plasmid. Expression analysis using the BAC-Dkk3-EGFP transgenic mice revealed that Dkk3 is expressed in retinal progenitor cells (RPCs at embryonic stages and in Müller glial cells in the adult retina. Since Müller glial cells may play a potential role in retinal regeneration, BAC-Dkk3-EGFP mice could be useful for retinal regeneration studies.

  6. Knowledge-based geographic information systems (KBGIS): New analytic and data management tools

    Science.gov (United States)

    Albert, T.M.

    1988-01-01

    In its simplest form, a geographic information system (GIS) may be viewed as a data base management system in which most of the data are spatially indexed, and upon which sets of procedures operate to answer queries about spatial entities represented in the data base. Utilization of artificial intelligence (AI) techniques can enhance greatly the capabilities of a GIS, particularly in handling very large, diverse data bases involved in the earth sciences. A KBGIS has been developed by the U.S. Geological Survey which incorporates AI techniques such as learning, expert systems, new data representation, and more. The system, which will be developed further and applied, is a prototype of the next generation of GIS's, an intelligent GIS, as well as an example of a general-purpose intelligent data handling system. The paper provides a description of KBGIS and its application, as well as the AI techniques involved. ?? 1988 International Association for Mathematical Geology.

  7. ISS Biotechnology Facility - Overview of Analytical Tools for Cellular Biotechnology Investigations

    Science.gov (United States)

    Jeevarajan, A. S.; Towe, B. C.; Anderson, M. M.; Gonda, S. R.; Pellis, N. R.

    2001-01-01

    The ISS Biotechnology Facility (BTF) platform provides scientists with a unique opportunity to carry out diverse experiments in a microgravity environment for an extended period of time. Although considerable progress has been made in preserving cells on the ISS for long periods of time for later return to Earth, future biotechnology experiments would desirably monitor, process, and analyze cells in a timely way on-orbit. One aspect of our work has been directed towards developing biochemical sensors for pH, glucose, oxygen, and carbon dioxide for perfused bioreactor system developed at Johnson Space Center. Another aspect is the examination and identification of new and advanced commercial biotechnologies that may have applications to on-orbit experiments.

  8. Analytical Tools for the Application of Operational Culture: A Case Study in the Trans-Sahel

    Science.gov (United States)

    2011-03-28

    literatures including nursing and applied health care, management sciences, legal studies, and political science. In these fields, theory generally...Erlbaum Associates 87 Grant, J. & Davis, L. (1997). ―Selection and Use of Content Experts for Instrument Development,‖ Research in Nursing and...June 6, 2009. Due to boycotts by opposition groups, the elections were rescheduled for July 18, 2009. Following the resignation of General Aziz in

  9. Development of road infrastructure as a tool of transforming Ibiono ...

    African Journals Online (AJOL)

    Global Journal of Social Sciences ... Development of road infrastructure as a tool of transforming Ibiono Ibom local government area. V Umoren ... The improvement of transportation network in the rural area in this regard becomes imperative.

  10. Psychometric properties of a Mental Health Team Development Audit Tool.

    LENUS (Irish Health Repository)

    Roncalli, Silvia

    2013-02-01

    To assist in improving team working in Community Mental Health Teams (CMHTs), the Mental Health Commission formulated a user-friendly but yet-to-be validated 25-item Mental Health Team Development Audit Tool (MHDAT).

  11. Water Loss Management: Tools and Methods for Developing Countries

    NARCIS (Netherlands)

    Mutikanga, H.E.

    2012-01-01

    Water utilities in developing countries are struggling to provide customers with a reliable level of service due to their peculiar water distribution characteristics including poorly zoned networks with irregular supply operating under restricted budgets. These unique conditions demand unique tools

  12. Water Loss Management : Tools and Methods for Developing Countries

    NARCIS (Netherlands)

    Mutikanga, H.E.

    2012-01-01

    Water utilities in developing countries are struggling to provide customers with a reliable level of service due to their peculiar water distribution characteristics including poorly zoned networks with irregular supply operating under restricted budgets. These unique conditions demand unique tools

  13. Economy diversification: a potent tool for tourism development in ...

    African Journals Online (AJOL)

    Economy diversification: a potent tool for tourism development in Nigeria. ... AFRREV STECH: An International Journal of Science and Technology ... The diversity of cultural attractions, the friendly disposition of the people, revamped National ...

  14. Bioinformatics tools for development of fast and cost effective simple ...

    African Journals Online (AJOL)

    Bioinformatics tools for development of fast and cost effective simple sequence repeat ... comparative mapping and exploration of functional genetic diversity in the ... Already, a number of computer programs have been implemented that aim at ...

  15. Real-time imaging as an emerging process analytical technology tool for monitoring of fluid bed coating process.

    Science.gov (United States)

    Naidu, Venkata Ramana; Deshpande, Rucha S; Syed, Moinuddin R; Wakte, Pravin S

    2018-07-01

    A direct imaging system (Eyecon TM ) was used as a Process Analytical Technology (PAT) tool to monitor fluid bed coating process. Eyecon TM generated real-time onscreen images, particle size and shape information of two identically manufactured laboratory-scale batches. Eyecon TM has accuracy of measuring the particle size increase of ±1 μm on particles in the size range of 50-3000 μm. Eyecon TM captured data every 2 s during the entire process. The moving average of D90 particle size values recorded by Eyecon TM were calculated for every 30 min to calculate the radial coating thickness of coated particles. After the completion of coating process, the radial coating thickness was found to be 11.3 and 9.11 μm, with a standard deviation of ±0.68 and 1.8 μm for Batch 1 and Batch 2, respectively. The coating thickness was also correlated with percent weight build-up by gel permeation chromatography (GPC) and dissolution. GPC indicated weight build-up of 10.6% and 9.27% for Batch 1 and Batch 2, respectively. In conclusion, weight build-up of 10% can also be correlated with 10 ± 2 μm increase in the coating thickness of pellets, indicating the potential applicability of real-time imaging as an endpoint determination tool for fluid bed coating process.

  16. Development of the major trauma case review tool.

    Science.gov (United States)

    Curtis, Kate; Mitchell, Rebecca; McCarthy, Amy; Wilson, Kellie; Van, Connie; Kennedy, Belinda; Tall, Gary; Holland, Andrew; Foster, Kim; Dickinson, Stuart; Stelfox, Henry T

    2017-02-28

    As many as half of all patients with major traumatic injuries do not receive the recommended care, with variance in preventable mortality reported across the globe. This variance highlights the need for a comprehensive process for monitoring and reviewing patient care, central to which is a consistent peer-review process that includes trauma system safety and human factors. There is no published, evidence-informed standardised tool that considers these factors for use in adult or paediatric trauma case peer-review. The aim of this research was to develop and validate a trauma case review tool to facilitate clinical review of paediatric trauma patient care in extracting information to facilitate monitoring, inform change and enable loop closure. Development of the trauma case review tool was multi-faceted, beginning with a review of the trauma audit tool literature. Data were extracted from the literature to inform iterative tool development using a consensus approach. Inter-rater agreement was assessed for both the pilot and finalised versions of the tool. The final trauma case review tool contained ten sections, including patient factors (such as pre-existing conditions), presenting problem, a timeline of events, factors contributing to the care delivery problem (including equipment, work environment, staff action, organizational factors), positive aspects of care and the outcome of panel discussion. After refinement, the inter-rater reliability of the human factors and outcome components of the tool improved with an average 86% agreement between raters. This research developed an evidence-informed tool for use in paediatric trauma case review that considers both system safety and human factors to facilitate clinical review of trauma patient care. This tool can be used to identify opportunities for improvement in trauma care and guide quality assurance activities. Validation is required in the adult population.

  17. Effectiveness of operation tools developed by KEKB operators

    International Nuclear Information System (INIS)

    Sugino, K.; Satoh, Y.; Kitabayashi, T.

    2004-01-01

    The main tasks of KEKB (High Energy Accelerator Research Organization B-physics) operators are beam tuning and injection, operation logging, monitoring of accelerator conditions and safety management. New beam tuning methods are frequently applied to KEKB in order to accomplish high luminosity. In such a situation, various operation tools have been developed by the operators to realize efficient operation. In this paper, we describe effectiveness of tools developed by the operators. (author)

  18. An integrated environment for developing object-oriented CAE tools

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, P.; Ryba, M.; Baitinger, U.G. [Integrated System Engeneering, Stuttgart (Germany)

    1996-12-31

    This paper presents how object oriented techniques can applied to improve the development of CAE tools. For the design of modular and reusable software systems we use predefined and well tested building blocks. These building blocks are reusable software components based on object-oriented technology which allows the assembling of software systems. Today CAE tools are typically very complex and computation extensive. Therefore we need a concept, that join the advantages of the object-oriented paradigm with the advantages of parallel and distributed programming. So we present a design environment for the development of concurrent-object oriented CAE tools called CoDO.

  19. A Decision-Analytic Feasibility Study of Upgrading Machinery at a Tools Workshop

    Directory of Open Access Journals (Sweden)

    M. L. Chew Hernandez

    2012-04-01

    Full Text Available This paper presents the evaluation, from a Decision Analysis point of view, of the feasibility of upgrading machinery at an existing metal-forming workshop. The Integral Decision Analysis (IDA methodology is applied to clarify the decision and develop a decision model. One of the key advantages of the IDA is its careful selection of the problem frame, allowing a correct problem definition. While following most of the original IDA methodology, an addition to this methodology is proposed in this work, that of using the strategic Means-Ends Objective Network as a backbone for the development of the decision model. The constructed decision model uses influence diagrams to include factual operator and vendor expertise, simulation to evaluate the alternatives and a utility function to take into account the risk attitude of the decision maker. Three alternatives are considered: Base (no modification, CNC (installing an automatic lathe and CF (installation of an automatic milling machine. The results are presented as a graph showing zones in which a particular alternative should be selected. The results show the potential of IDA to tackle technical decisions that are otherwise approached without the due care.

  20. Extensions of the Johnson-Neyman Technique to Linear Models with Curvilinear Effects: Derivations and Analytical Tools

    Science.gov (United States)

    Miller, Jason W.; Stromeyer, William R.; Schwieterman, Matthew A.

    2013-01-01

    The past decade has witnessed renewed interest in the use of the Johnson-Neyman (J-N) technique for calculating the regions of significance for the simple slope of a focal predictor on an outcome variable across the range of a second, continuous independent variable. Although tools have been developed to apply this technique to probe 2- and 3-way…

  1. Analytical tools for the study of cellular glycosylation in the immune system

    Directory of Open Access Journals (Sweden)

    Yvette eVan Kooyk

    2013-12-01

    Full Text Available It is becoming increasingly clear that glycosylation plays important role in intercellular communication within the immune system. Glycosylation-dependent interactions are crucial for the innate and adaptive immune system and regulate immune cell trafficking, synapse formation, activation, and survival. These functions take place by the cis or trans interaction of lectins with glycans. Classical immunological and biochemical methods have been used for the study of lectin function; however, the investigation of their counterparts, glycans, requires very specialized methodologies that have been extensively developed in the past decade within the Glycobiology scientific community. This Mini-Review intends to summarize the available technology for the study of glycan biosynthesis, its regulation and characterization for their application to the study of glycans in Immunology.

  2. Born analytical or adopted over time? a study investigating if new analytical tools can ensure the survival of market oriented startups.

    OpenAIRE

    Skogen, Hege Janson; De la Cruz, Kai

    2017-01-01

    Masteroppgave(MSc) in Master of Science in Strategic Marketing Management - Handelshøyskolen BI, 2017 This study investigates whether the prevalence of technological advances within quantitative analytics moderates the effect market orientation has on firm performance, and if startups can take advantage of the potential opportunities to ensure their own survival. For this purpose, the authors review previous literature in marketing orientation, startups, marketing analytics, an...

  3. Review of the Development of Learning Analytics Applied in College-Level Institutes

    Directory of Open Access Journals (Sweden)

    Ken-Zen Chen

    2014-07-01

    Full Text Available This article focuses on the recent development of Learning Analytics using higher education institutional big-data. It addresses current state of Learning Analytics, creates a shared understanding, and clarifies misconceptions about the field. This article also reviews prominent examples from peer institutions that are conducting analytics, identifies their data and methodological framework, and comments on market vendors and non-for-profit initiatives. Finally, it suggests an implementation agenda for potential institutions and their stakeholders by drafting necessary preparations and creating iterative implementation flows.

  4. Analytic calculation of radio emission from parametrized extensive air showers: A tool to extract shower parameters

    Science.gov (United States)

    Scholten, O.; Trinh, T. N. G.; de Vries, K. D.; Hare, B. M.

    2018-01-01

    The radio intensity and polarization footprint of a cosmic-ray induced extensive air shower is determined by the time-dependent structure of the current distribution residing in the plasma cloud at the shower front. In turn, the time dependence of the integrated charge-current distribution in the plasma cloud, the longitudinal shower structure, is determined by interesting physics which one would like to extract, such as the location and multiplicity of the primary cosmic-ray collision or the values of electric fields in the atmosphere during thunderstorms. To extract the structure of a shower from its footprint requires solving a complicated inverse problem. For this purpose we have developed a code that semianalytically calculates the radio footprint of an extensive air shower given an arbitrary longitudinal structure. This code can be used in an optimization procedure to extract the optimal longitudinal shower structure given a radio footprint. On the basis of air-shower universality we propose a simple parametrization of the structure of the plasma cloud. This parametrization is based on the results of Monte Carlo shower simulations. Deriving the parametrization also teaches which aspects of the plasma cloud are important for understanding the features seen in the radio-emission footprint. The calculated radio footprints are compared with microscopic CoREAS simulations.

  5. Benchtop-NMR and MRI--a new analytical tool in drug delivery research.

    Science.gov (United States)

    Metz, Hendrik; Mäder, Karsten

    2008-12-08

    During the last years, NMR spectroscopy and NMR imaging (magnetic resonance imaging, MRI) have been increasingly used to monitor drug delivery systems in vitro and in vivo. However, high installation and running costs of the commonly used superconducting magnet technology limits the application range and prevents the further spread of this non-invasive technology. Benchtop-NMR (BT-NMR) relaxometry uses permanent magnets and is much less cost intensive. BT-NMR relaxometry is commonly used in the food and chemical industry, but so far scarcely used in the pharmaceutical field. The paper shows on several examples that the application field of BT-NMR relaxometry can be extended into the field of drug delivery, including the characterisation of emulsions and lipid ingredients (e.g. the amount and physicochemical state of the lipid) and the monitoring of adsorption characteristics (e.g. oil binding of porous ingredients). The most exciting possibilities of BT-NMR technology are linked with the new development of BT-instruments with imaging capability. BT-MRI examples on the monitoring of hydration and swelling of HPMC-based monolayer and double-layer tablets are shown. BT-MRI opens new MRI opportunities for the non-invasive monitoring of drug delivery processes.

  6. Development Of Remote Hanford Connector Gasket Replacement Tooling For DWPF

    International Nuclear Information System (INIS)

    Krementz, D.; Coughlin, Jeffrey

    2009-01-01

    The Defense Waste Processing Facility (DWPF) requested the Savannah River National Laboratory (SRNL) to develop tooling and equipment to remotely replace gaskets in mechanical Hanford connectors to reduce personnel radiation exposure as compared to the current hands-on method. It is also expected that radiation levels will continually increase with future waste streams. The equipment is operated in the Remote Equipment Decontamination Cell (REDC), which is equipped with compressed air, two master-slave manipulators (MSM's) and an electro-mechanical manipulator (EMM) arm for operation of the remote tools. The REDC does not provide access to electrical power, so the equipment must be manually or pneumatically operated. The MSM's have a load limit at full extension of ten pounds, which limited the weight of the installation tool. In order to remotely replace Hanford connector gaskets several operations must be performed remotely, these include: removal of the spent gasket and retaining ring (retaining ring is also called snap ring), loading the new snap ring and gasket into the installation tool and installation of the new gasket into the Hanford connector. SRNL developed and tested tools that successfully perform all of the necessary tasks. Removal of snap rings from horizontal and vertical connectors is performed by separate air actuated retaining ring removal tools and is manipulated in the cell by the MSM. In order install a new gasket, the snap ring loader is used to load a new snap ring into a groove in the gasket installation tool. A new gasket is placed on the installation tool and retained by custom springs. An MSM lifts the installation tool and presses the mounted gasket against the connector block. Once the installation tool is in position, the gasket and snap ring are installed onto the connector by pneumatic actuation. All of the tools are located on a custom work table with a pneumatic valve station that directs compressed air to the desired tool and

  7. Temperature-controlled micro-TLC: a versatile green chemistry and fast analytical tool for separation and preliminary screening of steroids fraction from biological and environmental samples.

    Science.gov (United States)

    Zarzycki, Paweł K; Slączka, Magdalena M; Zarzycka, Magdalena B; Bartoszuk, Małgorzata A; Włodarczyk, Elżbieta; Baran, Michał J

    2011-11-01

    This paper is a continuation of our previous research focusing on development of micro-TLC methodology under temperature-controlled conditions. The main goal of present paper is to demonstrate separation and detection capability of micro-TLC technique involving simple analytical protocols without multi-steps sample pre-purification. One of the advantages of planar chromatography over its column counterpart is that each TLC run can be performed using non-previously used stationary phase. Therefore, it is possible to fractionate or separate complex samples characterized by heavy biological matrix loading. In present studies components of interest, mainly steroids, were isolated from biological samples like fish bile using single pre-treatment steps involving direct organic liquid extraction and/or deproteinization by freeze-drying method. Low-molecular mass compounds with polarity ranging from estetrol to progesterone derived from the environmental samples (lake water, untreated and treated sewage waters) were concentrated using optimized solid-phase extraction (SPE). Specific bands patterns for samples derived from surface water of the Middle Pomerania in northern part of Poland can be easily observed on obtained micro-TLC chromatograms. This approach can be useful as simple and non-expensive complementary method for fast control and screening of treated sewage water discharged by the municipal wastewater treatment plants. Moreover, our experimental results show the potential of micro-TLC as an efficient tool for retention measurements of a wide range of steroids under reversed-phase (RP) chromatographic conditions. These data can be used for further optimalization of SPE or HPLC systems working under RP conditions. Furthermore, we also demonstrated that micro-TLC based analytical approach can be applied as an effective method for the internal standard (IS) substance search. Generally, described methodology can be applied for fast fractionation or screening of the

  8. THz spectroscopy: An emerging technology for pharmaceutical development and pharmaceutical Process Analytical Technology (PAT) applications

    Science.gov (United States)

    Wu, Huiquan; Khan, Mansoor

    2012-08-01

    As an emerging technology, THz spectroscopy has gained increasing attention in the pharmaceutical area during the last decade. This attention is due to the fact that (1) it provides a promising alternative approach for in-depth understanding of both intermolecular interaction among pharmaceutical molecules and pharmaceutical product quality attributes; (2) it provides a promising alternative approach for enhanced process understanding of certain pharmaceutical manufacturing processes; and (3) the FDA pharmaceutical quality initiatives, most noticeably, the Process Analytical Technology (PAT) initiative. In this work, the current status and progress made so far on using THz spectroscopy for pharmaceutical development and pharmaceutical PAT applications are reviewed. In the spirit of demonstrating the utility of first principles modeling approach for addressing model validation challenge and reducing unnecessary model validation "burden" for facilitating THz pharmaceutical PAT applications, two scientific case studies based on published THz spectroscopy measurement results are created and discussed. Furthermore, other technical challenges and opportunities associated with adapting THz spectroscopy as a pharmaceutical PAT tool are highlighted.

  9. Development of an analytical microbial consortia method for enhancing performance monitoring at aerobic wastewater treatment plants.

    Science.gov (United States)

    Razban, Behrooz; Nelson, Kristina Y; McMartin, Dena W; Cullimore, D Roy; Wall, Michelle; Wang, Dunling

    2012-01-01

    An analytical method to produce profiles of bacterial biomass fatty acid methyl esters (FAME) was developed employing rapid agitation followed by static incubation (RASI) using selective media of wastewater microbial communities. The results were compiled to produce a unique library for comparison and performance analysis at a Wastewater Treatment Plant (WWTP). A total of 146 samples from the aerated WWTP, comprising 73 samples of each secondary and tertiary effluent, were included analyzed. For comparison purposes, all samples were evaluated via a similarity index (SI) with secondary effluents producing an SI of 0.88 with 2.7% variation and tertiary samples producing an SI 0.86 with 5.0% variation. The results also highlighted significant differences between the fatty acid profiles of the tertiary and secondary effluents indicating considerable shifts in the bacterial community profile between these treatment phases. The WWTP performance results using this method were highly replicable and reproducible indicating that the protocol has potential as a performance-monitoring tool for aerated WWTPs. The results quickly and accurately reflect shifts in dominant bacterial communities that result when processes operations and performance change.

  10. Analytical tools for assessing land degradation and its impact on soil quality

    Science.gov (United States)

    Bindraban, P. S.; Mantel, S.; Bai, Z.; de Jong, R.

    2010-05-01

    affects nutrient availability; in 20% of the potential maize growing areas productivity declined more then 50%. Overall, hydraulic soil functions were less affected by erosion in Kenya, still rain-fed yield decline exceeded 50 % on very steep lands. The simulated loss of topsoil in the Uruguay case mostly affected soil physical properties causing a reduction in rainfed wheat yields. Soil fertility status was little affected. In this paper we reflect on the use and effectiveness of these two approaches and discuss options for their (partial) integration as a means to better quantify extent, degree of degradation and the effects on soil quality. References Bai ZG, Dent DL, Olsson L and Schaepman ME 2008. Proxy global assessment of land degradation. Soil Use and Management 24, 223-234 Bindraban PS, Stoorvogel JJ, Jansen DM, Vlaming J and Groot JJR 2000. Land quality indicators for sustainable land management: proposed method for yield gap and soil nutrient balance. Agriculture, Ecosystems and the Environment 81, 103-112 Mantel S and van Engelen VWP 1999. Assessment of the impact of water erosion on productivity of maize in Kenya: an integrated modelling approach. Land Degradation & Development 10, 577-592 Mantel S, van Engelen VWP, Molfino JH and Resink JW 2000. Exploring biophysical potential and sustainability of wheat cultivation in Uruguay at the national level. Soil Use and Management 16, 270-278

  11. CorRECTreatment: a web-based decision support tool for rectal cancer treatment that uses the analytic hierarchy process and decision tree.

    Science.gov (United States)

    Suner, A; Karakülah, G; Dicle, O; Sökmen, S; Çelikoğlu, C C

    2015-01-01

    The selection of appropriate rectal cancer treatment is a complex multi-criteria decision making process, in which clinical decision support systems might be used to assist and enrich physicians' decision making. The objective of the study was to develop a web-based clinical decision support tool for physicians in the selection of potentially beneficial treatment options for patients with rectal cancer. The updated decision model contained 8 and 10 criteria in the first and second steps respectively. The decision support model, developed in our previous study by combining the Analytic Hierarchy Process (AHP) method which determines the priority of criteria and decision tree that formed using these priorities, was updated and applied to 388 patients data collected retrospectively. Later, a web-based decision support tool named corRECTreatment was developed. The compatibility of the treatment recommendations by the expert opinion and the decision support tool was examined for its consistency. Two surgeons were requested to recommend a treatment and an overall survival value for the treatment among 20 different cases that we selected and turned into a scenario among the most common and rare treatment options in the patient data set. In the AHP analyses of the criteria, it was found that the matrices, generated for both decision steps, were consistent (consistency ratiodecisions of experts, the consistency value for the most frequent cases was found to be 80% for the first decision step and 100% for the second decision step. Similarly, for rare cases consistency was 50% for the first decision step and 80% for the second decision step. The decision model and corRECTreatment, developed by applying these on real patient data, are expected to provide potential users with decision support in rectal cancer treatment processes and facilitate them in making projections about treatment options.

  12. Embedded Systems Development Tools: A MODUS-oriented Market Overview

    Directory of Open Access Journals (Sweden)

    Loupis Michalis

    2014-03-01

    Full Text Available Background: The embedded systems technology has perhaps been the most dominating technology in high-tech industries, in the past decade. The industry has correctly identified the potential of this technology and has put its efforts into exploring its full potential. Objectives: The goal of the paper is to explore the versatility of the application in the embedded system development based on one FP7-SME project. Methods/Approach: Embedded applications normally demand high resilience and quality, as well as conformity to quality standards and rigid performance. As a result embedded system developers have adopted software methods that yield high quality. The qualitative approach to examining embedded systems development tools has been applied in this work. Results: This paper presents a MODUS-oriented market analysis in the domains of Formal Verification tools, HW/SW co-simulation tools, Software Performance Optimization tools and Code Generation tools. Conclusions: The versatility of applications this technology serves is amazing. With all this performance potential, the technology has carried with itself a large number of issues which the industry essentially needs to resolve to be able to harness the full potential contained. The MODUS project toolset addressed four discrete domains of the ESD Software Market, in which corresponding open tools were developed

  13. Nexusing Charcoal in South Mozambique: A Proposal To Integrate the Nexus Charcoal-Food-Water Analysis With a Participatory Analytical and Systemic Tool

    Directory of Open Access Journals (Sweden)

    Ricardo Martins

    2018-06-01

    Full Text Available Nexus analysis identifies and explores the synergies and trade-offs between energy, food and water systems, considered as interdependent systems interacting with contextual drivers (e.g., climate change, poverty. The nexus is, thus, a valuable analytical and policy design supporting tool to address the widely discussed links between bioenergy, food and water. In fact, the Nexus provides a more integrative and broad approach in relation to the single isolated system approach that characterizes many bioenergy analysis and policies of the last decades. In particular, for the South of Mozambique, charcoal production, food insecurity and water scarcity have been related in separated studies and, thus, it would be expected that Nexus analysis has the potential to provide the basis for integrated policies and strategies focused on charcoal as a development factor. However, to date there is no Nexus analysis focused on charcoal in Mozambique, neither is there an assessment of the comprehensiveness and relevance of Nexus analysis when applied to charcoal energy systems. To address these gaps, this work applies the Nexus to the charcoal-food-water system in Mozambique, integrating national, regional and international studies analysing the isolated, or pairs of, systems. This integration results in a novel Nexus analysis graphic for charcoal-food-water relationship. Then, to access the comprehensiveness and depth of analysis, this Nexus analysis is critically compared with the 2MBio-A, a systems analytical and design framework based on a design tool specifically developed for Bioenergy (the 2MBio. The results reveal that Nexus analysis is “blind” to specific fundamental social, ecological and socio-historical dynamics of charcoal energy systems. The critical comparison also suggests the need to integrate the high level systems analysis of Nexus with non-deterministic, non-prescriptive participatory analysis tools, like the 2MBio-A, as a means to

  14. Analytical support of plant specific SAMG development validation of SAMG using MELCOR 1.8.5

    International Nuclear Information System (INIS)

    Duspiva, Jiri

    2006-01-01

    They are two NPPs in operation in Czech Republic. Both of NPPs operated in CR have already implemented EOPs, developed under collaboration with the WESE. The project on SAMG development has started and follows the previous one for EOPs also with the WESE as the leading organization. Plant specific SAMGs for the Temelin as well as Dukovany NPPs are based on the WOG generic SAMGs. The analytical support of plant specific SAMGs development is performed by the NRI Rez within the validation process. Basic conditions as well as their filling by NRI Rez are focused on analyst, analytical tools and their applications. More detail description is attended to the approach of the preparation of the MELCOR code application to the evaluation of hydrogen risk, validation of recent set of hydrogen passive autocatalytic recombiners and definition of proposals to amend system of hydrogen removal. Such kind of parametric calculations will request to perform very wide set of runs. It could not be possible with the whole plant model and decoupling of such calculation with storing of mass and energy sources into the containment is only one way. The example of this decoupling for the LOCA scenario is shown. It includes seven sources - heat losses from primary and secondary circuits, fluid blowndown through cold leg break, fission products blowndown through cold leg break, fluid blowndown through break in reactor pressure vessel bottom head, fission products through break in reactor pressure vessel bottom head, melt ejection from reactor pressure vessel to cavity and gas masses and heat losses from corium in cavity. The stand alone containment analysis was tested in two configurations - with or without taking of fission products into account. Testing showed very good agreement of all calculations until lower head failure and acceptable agreement after that. Also some problematic features appeared. The stand alone test with fission product was possible only after the changes in source code

  15. Measurement of very low amounts of arsenic in soils and waters: is ICP-MS the indispensable analytical tool?

    Science.gov (United States)

    López-García, Ignacio; Marín-Hernández, Juan Jose; Perez-Sirvent, Carmen; Hernandez-Cordoba, Manuel

    2017-04-01

    The toxicity of arsenic and its wide distribution in the nature needs nowadays not to be emphasized, and the convenience of reliable analytical tools for arsenic determination at very low levels is clear. Leaving aside atomic fluorescence spectrometers specifically designed for this purpose, the task is currently carried out by using inductively coupled plasma mass spectrometry (ICP-MS), a powerful but expensive technique that is not available in all laboratories. However, as the recent literature clearly shows, a similar or even better analytical performance for the determination of several elements can be achieved by replacing the ICP-MS instrument by an AAS spectrometer (which is commonly present in any laboratory and involves low acquisition and maintenance costs) provided that a simple microextraction step is used to preconcentrate the sample. This communication reports the optimization and results obtained with a new analytical procedure based on this idea and focused to the determination of very low concentrations of arsenic in waters and extracts from soils and sediments. The procedure is based on a micro-solid phase extraction process for the separation and preconcentration of arsenic that uses magnetic particles covered with silver nanoparticles functionalized with the sodium salt of 2-mercaptoethane-sulphonate (MESNa). This composite is obtained in an easy way in the laboratory. After the sample is treated with a low amount (only a few milligrams) of the magnetic material, the solid phase is separated by means of a magnetic field, and then introduced into an electrothermal atomizer (ETAAS) for arsenic determination. The preconcentration factor is close to 200 with a detection limit below 0.1 µg L-1 arsenic. Speciation of As(III) and As(V) can be achieved by means of two extractions carried out at different acidity. The results for total arsenic are verified using certified reference materials. The authors are grateful to the Comunidad Autonóma de la

  16. Development and Application of Predictive Tools for MHD Stability Limits in Tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Brennan, Dylan [Princeton Univ., NJ (United States); Miller, G. P. [Univ. of Tulsa, Tulsa, AZ (United States)

    2016-10-03

    This is a project to develop and apply analytic and computational tools to answer physics questions relevant to the onset of non-ideal magnetohydrodynamic (MHD) instabilities in toroidal magnetic confinement plasmas. The focused goal of the research is to develop predictive tools for these instabilities, including an inner layer solution algorithm, a resistive wall with control coils, and energetic particle effects. The production phase compares studies of instabilities in such systems using analytic techniques, PEST- III and NIMROD. Two important physics puzzles are targeted as guiding thrusts for the analyses. The first is to form an accurate description of the physics determining whether the resistive wall mode or a tearing mode will appear first as β is increased at low rotation and low error fields in DIII-D. The second is to understand the physical mechanism behind recent NIMROD results indicating strong damping and stabilization from energetic particle effects on linear resistive modes. The work seeks to develop a highly relevant predictive tool for ITER, advance the theoretical description of this physics in general, and analyze these instabilities in experiments such as ASDEX Upgrade, DIII-D, JET, JT-60U and NTSX. The awardee on this grant is the University of Tulsa. The research efforts are supervised principally by Dr. Brennan. Support is included for two graduate students, and a strong collaboration with Dr. John M. Finn of LANL. The work includes several ongoing collaborations with General Atomics, PPPL, and the NIMROD team, among others.

  17. Development and Application of Predictive Tools for MHD Stability Limits in Tokamaks

    International Nuclear Information System (INIS)

    Brennan, Dylan; Miller, G. P.

    2016-01-01

    This is a project to develop and apply analytic and computational tools to answer physics questions relevant to the onset of non-ideal magnetohydrodynamic (MHD) instabilities in toroidal magnetic confinement plasmas. The focused goal of the research is to develop predictive tools for these instabilities, including an inner layer solution algorithm, a resistive wall with control coils, and energetic particle effects. The production phase compares studies of instabilities in such systems using analytic techniques, PEST- III and NIMROD. Two important physics puzzles are targeted as guiding thrusts for the analyses. The first is to form an accurate description of the physics determining whether the resistive wall mode or a tearing mode will appear first as β is increased at low rotation and low error fields in DIII-D. The second is to understand the physical mechanism behind recent NIMROD results indicating strong damping and stabilization from energetic particle effects on linear resistive modes. The work seeks to develop a highly relevant predictive tool for ITER, advance the theoretical description of this physics in general, and analyze these instabilities in experiments such as ASDEX Upgrade, DIII-D, JET, JT-60U and NTSX. The awardee on this grant is the University of Tulsa. The research efforts are supervised principally by Dr. Brennan. Support is included for two graduate students, and a strong collaboration with Dr. John M. Finn of LANL. The work includes several ongoing collaborations with General Atomics, PPPL, and the NIMROD team, among others.

  18. Developing and Validating a New Classroom Climate Observation Assessment Tool.

    Science.gov (United States)

    Leff, Stephen S; Thomas, Duane E; Shapiro, Edward S; Paskewich, Brooke; Wilson, Kim; Necowitz-Hoffman, Beth; Jawad, Abbas F

    2011-01-01

    The climate of school classrooms, shaped by a combination of teacher practices and peer processes, is an important determinant for children's psychosocial functioning and is a primary factor affecting bullying and victimization. Given that there are relatively few theoretically-grounded and validated assessment tools designed to measure the social climate of classrooms, our research team developed an observation tool through participatory action research (PAR). This article details how the assessment tool was designed and preliminarily validated in 18 third-, fourth-, and fifth-grade classrooms in a large urban public school district. The goals of this study are to illustrate the feasibility of a PAR paradigm in measurement development, ascertain the psychometric properties of the assessment tool, and determine associations with different indices of classroom levels of relational and physical aggression.

  19. Development of Visualization Tools for ZPPR-15 Analysis

    International Nuclear Information System (INIS)

    Lee, Min Jae; Kim, Sang Ji

    2014-01-01

    ZPPR-15 cores consist of various drawer masters that have great heterogeneity. In order to build a proper homogenization strategy, the geometry of the drawer masters should be carefully analyzed with a visualization. Additionally, a visualization of drawer masters and the core configuration is necessary for minimizing human error during the input processing. For this purpose, visualization tools for a ZPPR-15 analysis has been developed based on a Perl script. In the following section, the implementation of visualization tools will be described and various visualization samples for both drawer masters and ZPPR-15 cores will be demonstrated. Visualization tools for drawer masters and a core configuration were successfully developed for a ZPPR-15 analysis. The visualization tools are expected to be useful for understanding ZPPR-15 experiments, and finding deterministic models of ZPPR-15. It turned out that generating VTK files is handy but the application of VTK files is powerful with the aid of the VISIT program

  20. Development of an improved low profile hub seal refurbishment tool

    International Nuclear Information System (INIS)

    Wagg, L.

    1997-01-01

    The hub seal area of a fuel channel feeder coupling can be exposed to oxygen in the atmosphere if protective measures are not taken during maintenance outages. Exposure to oxygen can lead to pitting of the hub seal area. Although this is a rare occurrence, the resulting possibility of the feeder coupling leakage led to the development of a feeder hub refurbishment tool. To reduce time and man-rem exposure during feeder hub seal refurbishment, an improved low profile hub seat refurbishing tool has been developed. The improved tool design will allow for quick and controlled removal of material, and the restoration of a roll-burnished finish equivalent to the original requirements. The new tool can be used in maintenance operations, with the end fitting present, as well as under retube-type circumstances, with the end fitting removed. (author)

  1. Developing e-marketing tools : Case company: CASTA Ltd.

    OpenAIRE

    Nguyen, Chi

    2014-01-01

    This Bachelor’s thesis topic is developing e-marketing tools for the B2C sector of CASTA Ltd. The final outcome is a set of online marketing tools guidelines that can improve business activities, especially marketing effectiveness. Based on the company’s status as a novice in online marketing field, the thesis will focus on the basic level of three specific online marketing tools, instead of covering the whole e-marketing subject. The theoretical framework first describes the concept of e...

  2. Analytical tools and methodologies for evaluation of residual life of contacting pressure tubes in the early generation of Indian PHWRs

    International Nuclear Information System (INIS)

    Sinha, S.K.; Madhusoodanan, K.; Rupani, B.B.; Sinha, R.K.

    2002-01-01

    In-service life of a contacting Zircaloy-2 pressure tube (PT) in the earlier generation of Indian PHWRs, is limited mainly due to the accelerated hydrogen pick-up and nucleation and growth of hydride blister(s) at the cold spot(s) formed on outside surface of pressure tube as a result of its contact with the calandria tube (CT). The activities involving development of the analytical models for simulating the degradation mechanisms leading to PT-CT contact and the methodologies for the revaluation of their safe life under such condition form the important part of our extensive programme for the life management of contacting pressure tubes. Since after the PT-CT contact, rate of hydrogen pick-up and nucleation and growth of hydride blisters govern the safe residual life of the pressure tube, two analytical models (a) hydrogen pick-up model ('HYCON') and (b) model for the nucleation and growth of hydride blister at the contact spot ('BLIST -2D') have been developed in-house to estimate the extent of degradation caused by them. Along with them, a methodology for evaluation of safe residual life has also been formulated for evaluating the safe residual life of the contacting channels. This paper gives the brief description of the models and the methodologies relevant for the contacting Zircaloy-2 pressure tubes. (author)

  3. DEVELOPMENT OF REMOTE TOOLS TO ASSESS THE EFFECTIVENESS AND QUALITY OF CAR SERVICE ENTERPRISES WORK

    Directory of Open Access Journals (Sweden)

    Vladimir Kozlovskiy

    2017-09-01

    Full Text Available The paper is updated development problem of remote tools to assess the effectiveness and work quality of the corporate car service enterprises. This paper presents the author’s methodology of activity estimation car service enterprises based on corporate information reflecting the report on the production activities of the service company. Specialized information system has been developed and implemented based on the proposed methodology. Specialized information system is the analytical tool for assessing the activities of enterprises the brand network of car service, for one of the largest national carmakers. The aim of research is development and realization of a monitoring system for certain areas of the car service work that significantly affect the quality process of the maintenance service. In addition, the paper is devoted to solving urgent issues of collection and processing of real data on warranty defects of cars.

  4. China adopts rural tourism as a development tool

    OpenAIRE

    Wo, Zhuo

    2006-01-01

    In recent years, rural tourism has become ever more prominent as a tool to increase visitors' awareness and as an attraction to a destination as well as a tool for economic development in the countryside of China. Rural tourism is a new type of tourism industry, which makes rural cmmunities as its sites, rural distinctive production, living styles and idyllic landscapes as its objects. The writer aims to analyze the theory of tourism life cycle proposed by Butler, current problems, types, mod...

  5. Method Engineering: Engineering of Information Systems Development Methods and Tools

    OpenAIRE

    Brinkkemper, J.N.; Brinkkemper, Sjaak

    1996-01-01

    This paper proposes the term method engineering for the research field of the construction of information systems development methods and tools. Some research issues in method engineering are identified. One major research topic in method engineering is discussed in depth: situational methods, i.e. the configuration of a project approach that is tuned to the project at hand. A language and support tool for the engineering of situational methods are discussed.

  6. The development, qualification and availability of AECL analytical, scientific and design codes

    International Nuclear Information System (INIS)

    Kupferschmidt, W.C.H.; Fehrenbach, P.J.; Wolgemuth, G.A.; McDonald, B.H.; Snell, V.G.

    2001-01-01

    Over the past several years, AECL has embarked on a comprehensive program to develop, qualify and support its key safety and licensing codes, and to make executable versions of these codes available to the international nuclear community. To this end, we have instituted a company-wide Software Quality Assurance (SQA) Program for Analytical, Scientific and Design Computer Programs to ensure that the design, development, maintenance, modification, procurement and use of computer codes within AECL is consistent with today's quality assurance standards. In addition, we have established a comprehensive Code Validation Project (CVP) with the goal of qualifying AECL's 'front-line' safety and licensing codes by 2001 December. The outcome of this initiative will be qualified codes, which are properly verified and validated for the expected range of applications, with associated statements of accuracy and uncertainty for each application. The code qualification program, based on the CSA N286.7 standard, is intended to ensure (1) that errors are not introduced into safety analyses because of deficiencies in the software, (2) that an auditable documentation base is assembled that demonstrates to the regulator that the codes are of acceptable quality, and (3) that these codes are formally qualified for their intended applications. Because AECL and the Canadian nuclear utilities (i.e., Ontario Power Generation, Bruce Power, Hydro Quebec and New Brunswick Power) generally use the same safety and licensing codes, the nuclear industry in Canada has agreed to work cooperatively together towards the development, qualification and maintenance of a common set of analysis tools, referred to as the Industry Standard Toolset (IST). This paper provides an overview of the AECL Software Quality Assurance Program and the Code Validation Project, and their associated linkages to the Canadian nuclear community's Industry Standard Toolset initiative to cooperatively qualify and support commonly

  7. Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope Ratio

    International Nuclear Information System (INIS)

    Keck, B.D.; Ognibene, T.; Vogel, J.S.

    2010-01-01

    Accelerator mass spectrometry (AMS) is an isotope based measurement technology that utilizes carbon-14 labeled compounds in the pharmaceutical development process to measure compounds at very low concentrations, empowers microdosing as an investigational tool, and extends the utility of 14 C labeled compounds to dramatically lower levels. It is a form of isotope ratio mass spectrometry that can provide either measurements of total compound equivalents or, when coupled to separation technology such as chromatography, quantitation of specific compounds. The properties of AMS as a measurement technique are investigated here, and the parameters of method validation are shown. AMS, independent of any separation technique to which it may be coupled, is shown to be accurate, linear, precise, and robust. As the sensitivity and universality of AMS is constantly being explored and expanded, this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and excretion of pharmaceutical compounds as a fundamental step in drug development. The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of 14 C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the 14 C label), stable across samples storage conditions for at least one year, linear over 4 orders of magnitude with an analytical range from one tenth Modern to at least 2000 Modern (instrument specific). Further, accuracy was excellent between 1 and 3 percent while precision expressed as coefficient of variation is between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of carbon-14 (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with 14 C corresponds to 30 fg equivalents. AMS

  8. Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope Ratio.

    Energy Technology Data Exchange (ETDEWEB)

    Keck, B D; Ognibene, T; Vogel, J S

    2010-02-05

    Accelerator mass spectrometry (AMS) is an isotope based measurement technology that utilizes carbon-14 labeled compounds in the pharmaceutical development process to measure compounds at very low concentrations, empowers microdosing as an investigational tool, and extends the utility of {sup 14}C labeled compounds to dramatically lower levels. It is a form of isotope ratio mass spectrometry that can provide either measurements of total compound equivalents or, when coupled to separation technology such as chromatography, quantitation of specific compounds. The properties of AMS as a measurement technique are investigated here, and the parameters of method validation are shown. AMS, independent of any separation technique to which it may be coupled, is shown to be accurate, linear, precise, and robust. As the sensitivity and universality of AMS is constantly being explored and expanded, this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and excretion of pharmaceutical compounds as a fundamental step in drug development. The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of {sup 14}C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the {sup 14}C label), stable across samples storage conditions for at least one year, linear over 4 orders of magnitude with an analytical range from one tenth Modern to at least 2000 Modern (instrument specific). Further, accuracy was excellent between 1 and 3 percent while precision expressed as coefficient of variation is between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of carbon-14 (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with {sup 14}C corresponds to 30 fg

  9. Development of tools for automatic generation of PLC code

    OpenAIRE

    Koutli, Maria; Chasapis, Georgios; Rochez, Jacques

    2014-01-01

    This Master thesis was performed at CERN and more specifically in the EN-ICE-PLC section. The Thesis describes the integration of two PLC platforms, that are based on CODESYS development tool, to the CERN defined industrial framework, UNICOS. CODESYS is a development tool for PLC programming, based on IEC 61131-3 standard, and is adopted by many PLC manufacturers. The two PLC development environments are, the SoMachine from Schneider and the TwinCAT from Beckhoff. The two CODESYS compatible P...

  10. Open source tools for ATR development and performance evaluation

    Science.gov (United States)

    Baumann, James M.; Dilsavor, Ronald L.; Stubbles, James; Mossing, John C.

    2002-07-01

    Early in almost every engineering project, a decision must be made about tools; should I buy off-the-shelf tools or should I develop my own. Either choice can involve significant cost and risk. Off-the-shelf tools may be readily available, but they can be expensive to purchase and to maintain licenses, and may not be flexible enough to satisfy all project requirements. On the other hand, developing new tools permits great flexibility, but it can be time- (and budget-) consuming, and the end product still may not work as intended. Open source software has the advantages of both approaches without many of the pitfalls. This paper examines the concept of open source software, including its history, unique culture, and informal yet closely followed conventions. These characteristics influence the quality and quantity of software available, and ultimately its suitability for serious ATR development work. We give an example where Python, an open source scripting language, and OpenEV, a viewing and analysis tool for geospatial data, have been incorporated into ATR performance evaluation projects. While this case highlights the successful use of open source tools, we also offer important insight into risks associated with this approach.

  11. Development of parallel/serial program analyzing tool

    International Nuclear Information System (INIS)

    Watanabe, Hiroshi; Nagao, Saichi; Takigawa, Yoshio; Kumakura, Toshimasa

    1999-03-01

    Japan Atomic Energy Research Institute has been developing 'KMtool', a parallel/serial program analyzing tool, in order to promote the parallelization of the science and engineering computation program. KMtool analyzes the performance of program written by FORTRAN77 and MPI, and it reduces the effort for parallelization. This paper describes development purpose, design, utilization and evaluation of KMtool. (author)

  12. Development of novel tools to measure food neophobia in children

    DEFF Research Database (Denmark)

    Damsbo-Svendsen, Marie; Frøst, Michael Bom; Olsen, Annemarie

    2017-01-01

    The main tool currently used to measure food neophobia (the Food Neophobia Scale, FNS, developed by Pliner & Hobden, 1992) may not remain optimal forever. It was developed around 25 years ago, and the perception and availability of “novel” and “ethnic” foods may have changed in the meantime. Cons...

  13. Waste Tank Organic Safety Program: Analytical methods development. Progress report, FY 1994

    International Nuclear Information System (INIS)

    Campbell, J.A.; Clauss, S.A.; Grant, K.E.

    1994-09-01

    The objectives of this task are to develop and document extraction and analysis methods for organics in waste tanks, and to extend these methods to the analysis of actual core samples to support the Waste Tank organic Safety Program. This report documents progress at Pacific Northwest Laboratory (a) during FY 1994 on methods development, the analysis of waste from Tank 241-C-103 (Tank C-103) and T-111, and the transfer of documented, developed analytical methods to personnel in the Analytical Chemistry Laboratory (ACL) and 222-S laboratory. This report is intended as an annual report, not a completed work

  14. The Application of State-of-the-Art Analytic Tools (Biosensors and Spectroscopy in Beverage and Food Fermentation Process Monitoring

    Directory of Open Access Journals (Sweden)

    Shaneel Chandra

    2017-09-01

    Full Text Available The production of several agricultural products and foods are linked with fermentation. Traditional methods used to control and monitor the quality of the products and processes are based on the use of simple chemical analysis. However, these methods are time-consuming and do not provide sufficient relevant information to guarantee the chemical changes during the process. Commonly used methods applied in the agriculture and food industries to monitor fermentation are those based on simple or single-point sensors, where only one parameter is measured (e.g., temperature or density. These sensors are used several times per day and are often the only source of data available from which the conditions and rate of fermentation are monitored. In the modern food industry, an ideal method to control and monitor the fermentation process should enable a direct, rapid, precise, and accurate determination of several target compounds, with minimal to no sample preparation or reagent consumption. Here, state-of-the-art advancements in both the application of sensors and analytical tools to monitor beverage and food fermentation processes will be discussed.

  15. ANALYTICAL, CRITICAL AND CREATIVE THINKING DEVELOPMENT OF THE GIFTED CHILDREN IN THE USA SCHOOLS

    Directory of Open Access Journals (Sweden)

    Anna Yurievna Kuvarzina

    2013-11-01

    Full Text Available Teachers of the gifted students should not only make an enrichment and acceleration program for them but also pay attention to the development of analytical, critical and creative thinking skills. Despite great interest for this issue in the last years, the topic of analytical and creative thinking is poorly considered in the textbooks for the gifted. In this article some methods, materials and programs of analytical, critical and creative thinking skills development, which are used in the USA, are described.  The author analyses and systematize the methods and also suggests some ways of their usage in the Russian educational system.Purpose: to analyze and systematize methods, materials and programs, that are used in the USA for teaching gifted children analytical, critical and creative thinking, for development of their capacities of problem-solving and decision-making. Methods and methodology of the research: analysis, comparison, principle of the historical and logical approaches unity.Results: positive results of employment of analytical, critical and creative thinking development methods were shown in the practical experience of teaching and educating gifted children in the USA educational system.Results employment field: the Russian Federation educational system: schools, special classes and courses for the gifted children.DOI: http://dx.doi.org/10.12731/2218-7405-2013-7-42

  16. The development and application of advanced analytical methods to commercial ICF reactor chambers. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cousseau, P.; Engelstad, R.; Henderson, D.L. [and others

    1997-10-01

    Progress is summarized in this report for each of the following tasks: (1) multi-dimensional radiation hydrodynamics computer code development; (2) 2D radiation-hydrodynamic code development; (3) ALARA: analytic and Laplacian adaptive radioactivity analysis -- a complete package for analysis of induced activation; (4) structural dynamics modeling of ICF reactor chambers; and (5) analysis of self-consistent target chamber clearing.

  17. Flammable gas safety program. Analytical methods development: FY 1994 progress report

    International Nuclear Information System (INIS)

    Campbell, J.A.; Clauss, S.; Grant, K.; Hoopes, V.; Lerner, B.; Lucke, R.; Mong, G.; Rau, J.; Wahl, K.; Steele, R.

    1994-09-01

    This report describes the status of developing analytical methods to account for the organic components in Hanford waste tanks, with particular focus on tanks assigned to the Flammable Gas Watch List. The methods that have been developed are illustrated by their application to samples obtained from Tank 241-SY-101 (Tank 101-SY)

  18. The development and application of advanced analytical methods to commercial ICF reactor chambers. Final report

    International Nuclear Information System (INIS)

    Cousseau, P.; Engelstad, R.; Henderson, D.L.

    1997-10-01

    Progress is summarized in this report for each of the following tasks: (1) multi-dimensional radiation hydrodynamics computer code development; (2) 2D radiation-hydrodynamic code development; (3) ALARA: analytic and Laplacian adaptive radioactivity analysis -- a complete package for analysis of induced activation; (4) structural dynamics modeling of ICF reactor chambers; and (5) analysis of self-consistent target chamber clearing

  19. Development of bore tools for pipe welding and cutting

    International Nuclear Information System (INIS)

    Oka, Kiyoshi; Ito, Akira; Takiguchi, Yuji

    1998-01-01

    In the International Thermonuclear Experimental Reactor (ITER), in-vessel components replacement and maintenance requires that connected cooling pipes be cut and removed beforehand and that new components be installed to which cooling pipes must be rewelded. All welding must be inspected for soundness after completion. These tasks require a new task concept for ensuring shielded areas and access from narrow ports. Thus, it became necessary to develop autonomous locomotion welding and cutting tools for branch and main pipes to weld pipes by in-pipe access; a system was proposed that cut and welded branch and main pipes after passing inside pipe curves, and elemental technologies developed. This paper introduces current development in tools for welding and cutting branch pipes and other tools for welding and cutting the main pipe. (author)

  20. Development of bore tools for pipe welding and cutting

    Energy Technology Data Exchange (ETDEWEB)

    Oka, Kiyoshi; Ito, Akira; Takiguchi, Yuji [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-04-01

    In the International Thermonuclear Experimental Reactor (ITER), in-vessel components replacement and maintenance requires that connected cooling pipes be cut and removed beforehand and that new components be installed to which cooling pipes must be rewelded. All welding must be inspected for soundness after completion. These tasks require a new task concept for ensuring shielded areas and access from narrow ports. Thus, it became necessary to develop autonomous locomotion welding and cutting tools for branch and main pipes to weld pipes by in-pipe access; a system was proposed that cut and welded branch and main pipes after passing inside pipe curves, and elemental technologies developed. This paper introduces current development in tools for welding and cutting branch pipes and other tools for welding and cutting the main pipe. (author)

  1. Development of a Safety Management Web Tool for Horse Stables.

    Science.gov (United States)

    Leppälä, Jarkko; Kolstrup, Christina Lunner; Pinzke, Stefan; Rautiainen, Risto; Saastamoinen, Markku; Särkijärvi, Susanna

    2015-11-12

    Managing a horse stable involves risks, which can have serious consequences for the stable, employees, clients, visitors and horses. Existing industrial or farm production risk management tools are not directly applicable to horse stables and they need to be adapted for use by managers of different types of stables. As a part of the InnoEquine project, an innovative web tool, InnoHorse, was developed to support horse stable managers in business, safety, pasture and manure management. A literature review, empirical horse stable case studies, expert panel workshops and stakeholder interviews were carried out to support the design. The InnoHorse web tool includes a safety section containing a horse stable safety map, stable safety checklists, and examples of good practices in stable safety, horse handling and rescue planning. This new horse stable safety management tool can also help in organizing work processes in horse stables in general.

  2. Development of thick wall welding and cutting tools for ITER

    International Nuclear Information System (INIS)

    Nakahira, Masataka; Takahashi, Hiroyuki; Akou, Kentaro; Koizumi, Koichi

    1998-01-01

    The Vacuum Vessel, which is a core component of International Thermonuclear Experimental Reactor (ITER), is required to be exchanged remotely in a case of accident such as superconducting coil failure. The in-vessel components such as blanket and divertor are planned to be exchanged or fixed. In these exchange or maintenance operations, the thick wall welding and cutting are inevitable and remote handling tools are necessary. The thick wall welding and cutting tools for blanket are under developing in the ITER R and D program. The design requirement is to weld or cut the stainless steel of 70 mm thickness in the narrow space. Tungsten inert gas (TIG) arc welding, plasma cutting and iodine laser welding/cutting are selected as primary option. Element welding and cutting tests, design of small tools to satisfy space requirement, test fabrication and performance tests were performed. This paper reports the tool design and overview of welding and cutting tests. (author)

  3. Development of thick wall welding and cutting tools for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Nakahira, Masataka; Takahashi, Hiroyuki; Akou, Kentaro; Koizumi, Koichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-04-01

    The Vacuum Vessel, which is a core component of International Thermonuclear Experimental Reactor (ITER), is required to be exchanged remotely in a case of accident such as superconducting coil failure. The in-vessel components such as blanket and divertor are planned to be exchanged or fixed. In these exchange or maintenance operations, the thick wall welding and cutting are inevitable and remote handling tools are necessary. The thick wall welding and cutting tools for blanket are under developing in the ITER R and D program. The design requirement is to weld or cut the stainless steel of 70 mm thickness in the narrow space. Tungsten inert gas (TIG) arc welding, plasma cutting and iodine laser welding/cutting are selected as primary option. Element welding and cutting tests, design of small tools to satisfy space requirement, test fabrication and performance tests were performed. This paper reports the tool design and overview of welding and cutting tests. (author)

  4. Development of remote handling tools for glove box

    International Nuclear Information System (INIS)

    Tomita, Yutaka; Nemoto, Takeshi; Denuma, Akio; Todokoro, Akio

    1996-01-01

    For a part of advanced nuclear fuel recycling technology development, we will separate and recover Americium from the MOX fuel scrap by solvent extraction. When we carry this examination, reduction of exposure from Americium-241 is one of important problems. To solve this problem fundamentally, we studied many joints type of the remote handling tools for glove box and produced a trial production machine. Also, we carried out basic function examinations of it. As a result, we got the prospect of development of the remote handling tools which could treat Americium in glove box. (author)

  5. Recent developments and future trends in solid phase microextraction techniques towards green analytical chemistry.

    Science.gov (United States)

    Spietelun, Agata; Marcinkowski, Łukasz; de la Guardia, Miguel; Namieśnik, Jacek

    2013-12-20

    Solid phase microextraction find increasing applications in the sample preparation step before chromatographic determination of analytes in samples with a complex composition. These techniques allow for integrating several operations, such as sample collection, extraction, analyte enrichment above the detection limit of a given measuring instrument and the isolation of analytes from sample matrix. In this work the information about novel methodological and instrumental solutions in relation to different variants of solid phase extraction techniques, solid-phase microextraction (SPME), stir bar sorptive extraction (SBSE) and magnetic solid phase extraction (MSPE) is presented, including practical applications of these techniques and a critical discussion about their advantages and disadvantages. The proposed solutions fulfill the requirements resulting from the concept of sustainable development, and specifically from the implementation of green chemistry principles in analytical laboratories. Therefore, particular attention was paid to the description of possible uses of novel, selective stationary phases in extraction techniques, inter alia, polymeric ionic liquids, carbon nanotubes, and silica- and carbon-based sorbents. The methodological solutions, together with properly matched sampling devices for collecting analytes from samples with varying matrix composition, enable us to reduce the number of errors during the sample preparation prior to chromatographic analysis as well as to limit the negative impact of this analytical step on the natural environment and the health of laboratory employees. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Direct analysis in real time mass spectrometry, a process analytical technology tool for real-time process monitoring in botanical drug manufacturing.

    Science.gov (United States)

    Wang, Lu; Zeng, Shanshan; Chen, Teng; Qu, Haibin

    2014-03-01

    A promising process analytical technology (PAT) tool has been introduced for batch processes monitoring. Direct analysis in real time mass spectrometry (DART-MS), a means of rapid fingerprint analysis, was applied to a percolation process with multi-constituent substances for an anti-cancer botanical preparation. Fifteen batches were carried out, including ten normal operations and five abnormal batches with artificial variations. The obtained multivariate data were analyzed by a multi-way partial least squares (MPLS) model. Control trajectories were derived from eight normal batches, and the qualification was tested by R(2) and Q(2). Accuracy and diagnosis capability of the batch model were then validated by the remaining batches. Assisted with high performance liquid chromatography (HPLC) determination, process faults were explained by corresponding variable contributions. Furthermore, a batch level model was developed to compare and assess the model performance. The present study has demonstrated that DART-MS is very promising in process monitoring in botanical manufacturing. Compared with general PAT tools, DART-MS offers a particular account on effective compositions and can be potentially used to improve batch quality and process consistency of samples in complex matrices. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Health Heritage© a web-based tool for the collection and assessment of family health history: initial user experience and analytic validity.

    Science.gov (United States)

    Cohn, W F; Ropka, M E; Pelletier, S L; Barrett, J R; Kinzie, M B; Harrison, M B; Liu, Z; Miesfeldt, S; Tucker, A L; Worrall, B B; Gibson, J; Mullins, I M; Elward, K S; Franko, J; Guterbock, T M; Knaus, W A

    2010-01-01

    A detailed family health history is currently the most potentially useful tool for diagnosis and risk assessment in clinical genetics. We developed and evaluated the usability and analytic validity of a patient-driven web-based family health history collection and analysis tool. Health Heritage(©) guides users through the collection of their family health history by relative, generates a pedigree, completes risk assessment, stratification, and recommendations for 89 conditions. We compared the performance of Health Heritage to that of Usual Care using a nonrandomized cohort trial of 109 volunteers. We contrasted the completeness and sensitivity of family health history collection and risk assessments derived from Health Heritage and Usual Care to those obtained by genetic counselors and genetic assessment teams. Nearly half (42%) of the Health Heritage participants reported discovery of health risks; 63% found the information easy to understand and 56% indicated it would change their health behavior. Health Heritage consistently outperformed Usual Care in the completeness and accuracy of family health history collection, identifying 60% of the elevated risk conditions specified by the genetic team versus 24% identified by Usual Care. Health Heritage also had greater sensitivity than Usual Care when comparing the identification of risks. These results suggest a strong role for automated family health history collection and risk assessment and underscore the potential of these data to serve as the foundation for comprehensive, cost-effective personalized genomic medicine. Copyright © 2010 S. Karger AG, Basel.

  8. Developing shape analysis tools to assist complex spatial decision making

    Energy Technology Data Exchange (ETDEWEB)

    Mackey, H.E. [Westinghouse Savannah River Company, AIKEN, SC (United States); Ehler, G.B.; Cowen, D. [South Carolina Univ., Columbia, SC (United States)

    1996-05-31

    The objective of this research was to develop and implement a shape identification measure within a geographic information system, specifically one that incorporates analytical modeling for site location planning. The application that was developed incorporated a location model within a raster-based GIS, which helped address critical performance issues for the decision support system. Binary matrices, which approximate the object`s geometrical form, are passed over the grided data structure and allow identification of irregular and regularly shaped objects. Lastly, the issue of shape rotation is addressed and is resolved by constructing unique matrices corresponding to the object`s orientation

  9. Developing shape analysis tools to assist complex spatial decision making

    International Nuclear Information System (INIS)

    Mackey, H.E.; Ehler, G.B.; Cowen, D.

    1996-01-01

    The objective of this research was to develop and implement a shape identification measure within a geographic information system, specifically one that incorporates analytical modeling for site location planning. The application that was developed incorporated a location model within a raster-based GIS, which helped address critical performance issues for the decision support system. Binary matrices, which approximate the object's geometrical form, are passed over the grided data structure and allow identification of irregular and regularly shaped objects. Lastly, the issue of shape rotation is addressed and is resolved by constructing unique matrices corresponding to the object's orientation

  10. Developing a testing tool for a port terminal operating system

    OpenAIRE

    Perič, Miran

    2011-01-01

    This thesis describes the approach for development of a testing tool which simulates the terminal operating system. Main result of the thesis is presentation of the approach for the development and operation of the application, which was developed in C# programming language. The application communicates with the port information system by messages exchange. Data is stored on a database. With the support of the application we can test the port information system before of future implem...

  11. Process development and tooling design for intrinsic hybrid composites

    Science.gov (United States)

    Riemer, M.; Müller, R.; Drossel, W. G.; Landgrebe, D.

    2017-09-01

    Hybrid parts, which combine the advantages of different material classes, are moving into the focus of lightweight applications. This development is amplified by their high potential for usage in the field of crash relevant structures. By the current state of the art, hybrid parts are mainly made in separate, subsequent forming and joining processes. By using the concept of an intrinsic hybrid, the shaping of the part and the joining of the different materials are performed in a single process step for shortening the overall processing time and thereby the manufacturing costs. The investigated hybrid part is made from continuous fibre reinforced plastic (FRP), in which a metallic reinforcement structure is integrated. The connection between these layered components is realized by a combination of adhesive bonding and a geometrical form fit. The form fit elements are intrinsically generated during the forming process. This contribution regards the development of the forming process and the design of the forming tool for the single step production of a hybrid part. To this end a forming tool, which combines the thermo-forming and the metal forming process, is developed. The main challenge by designing the tool is the temperature management of the tool elements for the variothermal forming process. The process parameters are determined in basic tests and finite element (FE) simulation studies. On the basis of these investigations a control concept for the steering of the motion axes and the tool temperature is developed. Forming tests are carried out with the developed tool and the manufactured parts are analysed by computer assisted tomography (CT) scans.

  12. Methodological framework, analytical tool and database for the assessment of climate change impacts, adaptation and vulnerability in Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Skougaard Kaspersen, P.; Halsnaes, K.; Gregg, J.; Drews, M.

    2012-12-15

    In this report we provide recommendations about how more consistent studies and data can be provided based on available modelling tools and data for integrated assessment of climate change risks and adaptation options. It is concluded that integrated assessments within this area requires the use of a wide range of data and models in order to cover the full chain of elements including climate modelling, impact, risks, costs, social issues, and decision making. As an outcome of this activity a comprehensive data and modelling tool named Danish Integrated Assessment System (DIAS) has been developed, this may be used by researchers within the field. DIAS has been implemented and tested in a case study on urban flooding caused by extreme precipitation in Aarhus, and this study highlights the usefulness of integrating data, models, and methods from several disciplines into a common framework. DIAS is an attempt to describe such a framework with regards to integrated analysis of climate impacts and adaptation. The final product of the DTU KFT project ''Tool for Vulnerability analysis'' is NOT a user friendly Climate Adaptation tool ready for various types of analysis that may directly be used by decision makers and consultant on their own. Rather developed methodology and collected/available data can serve as a starting point for case specific analyses. For this reason alone this work should very much be viewed as an attempt to coordinate research, data and models outputs between different research institutes from various disciplines. It is unquestionable that there is a future need to integrate information for areas not yet included, and it is very likely that such efforts will depend on research projects conducted in different climate change adaptation areas and sectors in Denmark. (Author)

  13. The Development of a Tool for Sustainable Building Design:

    DEFF Research Database (Denmark)

    Tine Ring Hansen, Hanne; Knudstrup, Mary-Ann

    2009-01-01

    for sustainable buildings, as well as, an analysis of the relationship between the different approaches (e.g. low-energy, environmental, green building, solar architecture, bio-climatic architecture etc.) to sustainable building design and these indicators. The paper furthermore discusses how sustainable......The understanding of sustainable building has changed over time along with the architectural interpretation of sustainability. The paper presents the results of a comparative analysis of the indicators found in different internationally acclaimed and Danish certification schemes and standards...... architecture will gain more focus in the coming years, thus, establishing the need for the development of a new tool and methodology, The paper furthermore describes the background and considerations involved in the development of a design support tool for sustainable building design. A tool which considers...

  14. Development of culturally sensitive dialog tools in diabetes education

    Directory of Open Access Journals (Sweden)

    Nana Folmann Hempler

    2015-01-01

    Full Text Available Person-centeredness is a goal in diabetes education, and cultural influences are important to consider in this regard. This report describes the use of a design-based research approach to develop culturally sensitive dialog tools to support person-centered dietary education targeting Pakistani immigrants in Denmark with type 2 diabetes. The approach appears to be a promising method to develop dialog tools for patient education that are culturally sensitive, thereby increasing their acceptability among ethnic minority groups. The process also emphasizes the importance of adequate training and competencies in the application of dialog tools and of alignment between researchers and health care professionals with regards to the educational philosophy underlying their use.

  15. Experimental design and multiple response optimization. Using the desirability function in analytical methods development.

    Science.gov (United States)

    Candioti, Luciana Vera; De Zan, María M; Cámara, María S; Goicoechea, Héctor C

    2014-06-01

    A review about the application of response surface methodology (RSM) when several responses have to be simultaneously optimized in the field of analytical methods development is presented. Several critical issues like response transformation, multiple response optimization and modeling with least squares and artificial neural networks are discussed. Most recent analytical applications are presented in the context of analytLaboratorio de Control de Calidad de Medicamentos (LCCM), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, C.C. 242, S3000ZAA Santa Fe, ArgentinaLaboratorio de Control de Calidad de Medicamentos (LCCM), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, C.C. 242, S3000ZAA Santa Fe, Argentinaical methods development, especially in multiple response optimization procedures using the desirability function. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Developing an Analytical Framework: Incorporating Ecosystem Services into Decision Making - Proceedings of a Workshop

    Science.gov (United States)

    Hogan, Dianna; Arthaud, Greg; Pattison, Malka; Sayre, Roger G.; Shapiro, Carl

    2010-01-01

    The analytical framework for understanding ecosystem services in conservation, resource management, and development decisions is multidisciplinary, encompassing a combination of the natural and social sciences. This report summarizes a workshop on 'Developing an Analytical Framework: Incorporating Ecosystem Services into Decision Making,' which focused on the analytical process and on identifying research priorities for assessing ecosystem services, their production and use, their spatial and temporal characteristics, their relationship with natural systems, and their interdependencies. Attendees discussed research directions and solutions to key challenges in developing the analytical framework. The discussion was divided into two sessions: (1) the measurement framework: quantities and values, and (2) the spatial framework: mapping and spatial relationships. This workshop was the second of three preconference workshops associated with ACES 2008 (A Conference on Ecosystem Services): Using Science for Decision Making in Dynamic Systems. These three workshops were designed to explore the ACES 2008 theme on decision making and how the concept of ecosystem services can be more effectively incorporated into conservation, restoration, resource management, and development decisions. Preconference workshop 1, 'Developing a Vision: Incorporating Ecosystem Services into Decision Making,' was held on April 15, 2008, in Cambridge, MA. In preconference workshop 1, participants addressed what would have to happen to make ecosystem services be used more routinely and effectively in conservation, restoration, resource management, and development decisions, and they identified some key challenges in developing the analytical framework. Preconference workshop 3, 'Developing an Institutional Framework: Incorporating Ecosystem Services into Decision Making,' was held on October 30, 2008, in Albuquerque, NM; participants examined the relationship between the institutional framework and

  17. Development and Testing of the Church Environment Audit Tool.

    Science.gov (United States)

    Kaczynski, Andrew T; Jake-Schoffman, Danielle E; Peters, Nathan A; Dunn, Caroline G; Wilcox, Sara; Forthofer, Melinda

    2018-05-01

    In this paper, we describe development and reliability testing of a novel tool to evaluate the physical environment of faith-based settings pertaining to opportunities for physical activity (PA) and healthy eating (HE). Tool development was a multistage process including a review of similar tools, stakeholder review, expert feedback, and pilot testing. Final tool sections included indoor opportunities for PA, outdoor opportunities for PA, food preparation equipment, kitchen type, food for purchase, beverages for purchase, and media. Two independent audits were completed at 54 churches. Interrater reliability (IRR) was determined with Kappa and percent agreement. Of 218 items, 102 were assessed for IRR and 116 could not be assessed because they were not present at enough churches. Percent agreement for all 102 items was over 80%. For 42 items, the sample was too homogeneous to assess Kappa. Forty-six of the remaining items had Kappas greater than 0.60 (25 items 0.80-1.00; 21 items 0.60-0.79), indicating substantial to almost perfect agreement. The tool proved reliable and efficient for assessing church environments and identifying potential intervention points. Future work can focus on applications within faith-based partnerships to understand how church environments influence diverse health outcomes.

  18. Development of the Writing Readiness Inventory Tool in Context (WRITIC)

    NARCIS (Netherlands)

    van Hartingsveldt, Margo J.; de Vries, Liesbeth; Cup, Edith HC; de Groot, Imelda JM; Nijhuis-van der Sanden, Maria WG

    2014-01-01

    This article describes the development of the Writing Readiness Inventory Tool in Context (WRITIC), a measurement evaluating writing readiness in Dutch kindergarten children (5 and 6 years old). Content validity was established through 10 expert evaluations in three rounds. Construct validity was

  19. Sharpening a Tool for Teaching: The Zone of Proximal Development

    Science.gov (United States)

    Wass, Rob; Golding, Clinton

    2014-01-01

    Vygotsky's Zone of Proximal Development (ZPD) provides an important understanding of learning, but its implications for teachers are often unclear or limited and could be further explored. We use conceptual analysis to sharpen the ZPD as a teaching tool, illustrated with examples from teaching critical thinking in zoology. Our conclusions are…

  20. Method and Tools for Development of Advanced Instructional Systems

    NARCIS (Netherlands)

    Arend, J. van der; Riemersma, J.B.J.

    1994-01-01

    The application of advanced instructional systems (AISs), like computer-based training systems, intelligent tutoring systems and training simulators, is widely spread within the Royal Netherlands Army. As a consequence there is a growing interest in methods and tools to develop effective and

  1. Method Engineering: Engineering of Information Systems Development Methods and Tools

    NARCIS (Netherlands)

    Brinkkemper, J.N.; Brinkkemper, Sjaak

    1996-01-01

    This paper proposes the term method engineering for the research field of the construction of information systems development methods and tools. Some research issues in method engineering are identified. One major research topic in method engineering is discussed in depth: situational methods, i.e.

  2. Development of a New Measurement Tool for Individualism and Collectivism

    Science.gov (United States)

    Shulruf, Boaz; Hattie, John; Dixon, Robyn

    2007-01-01

    A new measurement tool for individualism and collectivism has been developed to address critical methodological issues in this field of social psychology. This new measure, the Auckland Individualism and Collectivism Scale (AICS), defines three dimensions of individualism: (a) responsibility (acknowledging one's responsibility for one's actions),…

  3. Interactive test tool for interoperable C-ITS development

    NARCIS (Netherlands)

    Voronov, A.; Englund, C.; Bengtsson, H.H.; Chen, L.; Ploeg, J.; Jongh, J.F.C.M. de; Sluis, H.J.D. van de

    2015-01-01

    This paper presents the architecture of an Interactive Test Tool (ITT) for interoperability testing of Cooperative Intelligent Transport Systems (C-ITS). Cooperative systems are developed by different manufacturers at different locations, which makes interoperability testing a tedious task. Up until

  4. Methodology for Developing a Diesel Exhaust After Treatment Simulation Tool

    DEFF Research Database (Denmark)

    Christiansen, Tine; Jensen, Johanne; Åberg, Andreas

    2018-01-01

    A methodology for the development of catalyst models is presented. Also, a methodology of the implementation of such models into a modular simulation tool, which simulates the units in succession, is presented. A case study is presented illustrating how suitable models can be found and used for s...

  5. Millennium Development Goals: Tool or token of global social governance?

    NARCIS (Netherlands)

    Al Raee, M.; Amoateng, Elvis; Avenyo, E.K.; Beshay, Youssef; Bierbaum, M.; Keijser, C.; Sinha, R.

    2014-01-01

    In this paper we argue that the Millennium Development Goals (MDGs) experience suggests that Global Social Governance (GSG) exists and that the MDGs have been an effective tool in creating a global accountability framework despite shortcomings mainly arising in the formulation process. The paper

  6. EAST: Developing an Electronic Assessment and Storage Tool.

    Science.gov (United States)

    Edwards, Katherine I.; Fernandez, Eugenia; Milionis, Tracey M.; Williamson, David M.

    2002-01-01

    Describes the purpose, development, analysis, prototyping, and features of the Electronic Assessment and Storage Tool (EAST). The Web-based system aids curriculum assessment at Purdue School of Engineering and Technology at Indiana University Purdue University Indianapolis through the ability to easily store artifacts in electronic form, support…

  7. Developing a Benchmark Tool for Sustainable Consumption: An Iterative Process

    Science.gov (United States)

    Heiskanen, E.; Timonen, P.; Nissinen, A.; Gronroos, J.; Honkanen, A.; Katajajuuri, J. -M.; Kettunen, J.; Kurppa, S.; Makinen, T.; Seppala, J.; Silvenius, F.; Virtanen, Y.; Voutilainen, P.

    2007-01-01

    This article presents the development process of a consumer-oriented, illustrative benchmarking tool enabling consumers to use the results of environmental life cycle assessment (LCA) to make informed decisions. LCA provides a wealth of information on the environmental impacts of products, but its results are very difficult to present concisely…

  8. Development of Desktop Computing Applications and Engineering Tools on GPUs

    DEFF Research Database (Denmark)

    Sørensen, Hans Henrik Brandenborg; Glimberg, Stefan Lemvig; Hansen, Toke Jansen

    (GPUs) for high-performance computing applications and software tools in science and engineering, inverse problems, visualization, imaging, dynamic optimization. The goals are to contribute to the development of new state-of-the-art mathematical models and algorithms for maximum throughout performance...

  9. Reflective Journaling: A Tool for Teacher Professional Development

    Science.gov (United States)

    Dreyer, Lorna M.

    2015-01-01

    This qualitative study explores the introduction of postgraduate education students to reflective journaling as a tool for professional development. Students were purposefully selected to keep a weekly journal in which they reflected in and on the activities (methodologies, techniques, strategies) they engaged in while executing a workplace…

  10. Development of the Operational Events Groups Ranking Tool

    International Nuclear Information System (INIS)

    Simic, Zdenko; Banov, Reni

    2014-01-01

    Both because of complexity and ageing, facilities like nuclear power plants require feedback from the operating experience in order to further improve safety and operation performance. That is the reason why significant effort is dedicated to operating experience feedback. This paper contains description of the specification and development of the application for the operating events ranking software tool. Robust and consistent way of selecting most important events for detail investigation is important because it is not feasible or even useful to investigate all of them. Development of the tool is based on the comprehensive events characterisation and methodical prioritization. This includes rich set of events parameters which allow their top level preliminary analysis, different ways of groupings and even to evaluate uncertainty propagation to the ranking results. One distinct feature of the implemented method is that user (i.e., expert) could determine how important is particular ranking parameter based on their pairwise comparison. For tools demonstration and usability it is crucial that sample database is also created. For useful analysis the whole set of events for 5 years is selected and characterised. Based on the preliminary results this tool seems valuable for new preliminary prospective on data as whole, and especially for the identification of events groups which should have priority in the more detailed assessment. The results are consisting of different informative views on the events groups importance and related sensitivity and uncertainty results. This presents valuable tool for improving overall picture about specific operating experience and also for helping identify the most important events groups for further assessment. It is clear that completeness and consistency of the input data characterisation is very important to get full and valuable importance ranking. Method and tool development described in this paper is part of continuous effort of

  11. Developing a Conceptual Design Engineering Toolbox and its Tools

    Directory of Open Access Journals (Sweden)

    R. W. Vroom

    2004-01-01

    Full Text Available In order to develop a successful product, a design engineer needs to pay attention to all relevant aspects of that product. Many tools are available, software, books, websites, and commercial services. To unlock these potentially useful sources of knowledge, we are developing C-DET, a toolbox for conceptual design engineering. The idea of C-DET is that designers are supported by a system that provides them with a knowledge portal on one hand, and a system to store their current work on the other. The knowledge portal is to help the designer to find the most appropriate sites, experts, tools etc. at a short notice. Such a toolbox offers opportunities to incorporate extra functionalities to support the design engineering work. One of these functionalities could be to help the designer to reach a balanced comprehension in his work. Furthermore C-DET enables researchers in the area of design engineering and design engineers themselves to find each other or their work earlier and more easily. Newly developed design tools that can be used by design engineers but have not yet been developed up to a commercial level could be linked to by C-DET. In this way these tools can be evaluated in an early stage by design engineers who would like to use them. This paper describes the first prototypes of C-DET, an example of the development of a design tool that enables designers to forecast the use process and an example of the future functionalities of C-DET such as balanced comprehension.

  12. Development of the Central Dogma Concept Inventory (CDCI) Assessment Tool

    OpenAIRE

    Newman, Dina L.; Snyder, Christopher W.; Fisk, J. Nick; Wright, L. Kate

    2016-01-01

    Scientific teaching requires scientifically constructed, field-tested instruments to accurately evaluate student thinking and gauge teacher effectiveness. We have developed a 23-question, multiple select?format assessment of student understanding of the essential concepts of the central dogma of molecular biology that is appropriate for all levels of undergraduate biology. Questions for the Central Dogma Concept Inventory (CDCI) tool were developed and iteratively revised based on student lan...

  13. Development of bilingual tools to assess functional health patterns.

    Science.gov (United States)

    Krozy, R E; McCarthy, N C

    1999-01-01

    The theory and process of developing bilingual assessment tools based on Gordon's 11 functional health patterns. To facilitate assessing the individual, family, and community in a student clinical practicum in a Spanish-speaking country. Multiple family and community health promotion theories; translation theories, Gordon's Manual of Nursing Diagnosis (1982); translation/back-translation involving Ecuadorian faculty and students; student community assessments; faculty and staff workshops in Ecuador. Bilingual, culturally sensitive health assessment tools facilitate history taking, establish nursing diagnoses and interventions, and promote mutual learning. These outcomes demonstrate potential application to other systems in the international nursing community.

  14. XSC plasma control: Tool development for the session leader

    International Nuclear Information System (INIS)

    Ambrosino, G.; Albanese, R.; Ariola, M.; Cenedese, A.; Crisanti, F.; Tommasi, G. De; Mattei, M.; Piccolo, F.; Pironti, A.; Sartori, F.; Villone, F.

    2005-01-01

    A new model-based shape controller (XSC, i.e., eXtreme Shape Controller) able to operate with high elongation and triangularity plasmas has been designed and implemented at JET in 2003. The use of the XSC needs a number of steps, which at present are not automated and therefore imply the involvement of several experts. To help the session leader in preparing an experiment, a number of software tools are needed. The paper describes the SW tools that are currently in the developing phase, and describes the new framework for the preparation of a JET experiment

  15. Designing the user experience of game development tools

    CERN Document Server

    Lightbown, David

    2015-01-01

    The Big Green Button My Story Who Should Read this Book? Companion Website and Twitter Account Before we BeginWelcome to Designing the User Experience of Game Development ToolsWhat Will We Learn in This Chapter?What Is This Book About?Defining User ExperienceThe Value of Improving the User Experience of Our ToolsParallels Between User Experience and Game DesignHow Do People Benefit From an Improved User Experience?Finding the Right BalanceWrapping UpThe User-Centered Design ProcessWhat Will We

  16. Social Live Streaming tools for the development of Virtual Workshops

    Directory of Open Access Journals (Sweden)

    C. García-García

    2017-04-01

    This paper proposes the use of Social Live Streaming Tools in mobile devices in order to facilitate the development of creative workshops, using the virtual territory as co-creation area with the aim of promoting one-to-many communications, so that a lecturer can perform a mass communication, in real time and delocalized, without losing the possibility of interact with the audience. These tools also allow the possibility for each member of a creative team to swap between different roles (viewer at some times or lecturer at others, thus stimulating the creative process through social participation.

  17. The effects of a learning analytics empowered technology on students' arithmetic skill development

    NARCIS (Netherlands)

    Molenaar, I.; Knoop-van Campen, C.A.N.; Hasselman, F.W.

    2017-01-01

    Learning analytics empowered educational technologies (LA-ET) in primary classrooms allow for blended learning scenarios with teacher-lead instructions, class-paced and individually-paced practice. This quasi-experimental study investigates the effects of a LA-ET on the development of students'

  18. Supporting Adaptive Learning Pathways through the Use of Learning Analytics: Developments, Challenges and Future Opportunities

    Science.gov (United States)

    Mavroudi, Anna; Giannakos, Michail; Krogstie, John

    2018-01-01

    Learning Analytics (LA) and adaptive learning are inextricably linked since they both foster technology-supported learner-centred education. This study identifies developments focusing on their interplay and emphasises insufficiently investigated directions which display a higher innovation potential. Twenty-one peer-reviewed studies are…

  19. Some developments in human reliability analysis approaches and tools

    Energy Technology Data Exchange (ETDEWEB)

    Hannaman, G W; Worledge, D H

    1988-01-01

    Since human actions have been recognized as an important contributor to safety of operating plants in most industries, research has been performed to better understand and account for the way operators interact during accidents through the control room and equipment interface. This paper describes the integration of a series of research projects sponsored by the Electric Power Research Institute to strengthen the methods for performing the human reliability analysis portion of the probabilistic safety studies. It focuses on the analytical framework used to guide the analysis, the development of the models for quantifying time-dependent actions, and simulator experiments used to validate the models.

  20. ADVANCED AND RAPID DEVELOPMENT OF DYNAMIC ANALYSIS TOOLS FOR JAVA

    Directory of Open Access Journals (Sweden)

    Alex Villazón

    2012-01-01

    Full Text Available Low-level bytecode instrumentation techniques are widely used in many software-engineering tools for the Java Virtual Machine (JVM, that perform some form of dynamic program analysis, such as profilers or debuggers. While program manipulation at the bytecode level is very flexible, because the possible bytecode transformations are not restricted, tool development based on this technique is tedious and error-prone. As a promising alternative, the specification of bytecode instrumentation at a higher level using aspect-oriented programming (AOP can reduce tool development time and cost. Unfortunately, prevailing AOP frameworks lack some features that are essential for certain dynamic analyses. In this article, we focus on three common shortcomings in AOP frameworks with respect to the development of aspect-based tools - (1 the lack of mechanisms for passing data between woven advices in local variables, (2 the support for user-defined static analyses at weaving time, and (3 the absence of pointcuts at the level of individual basic blocks of code. We propose @J, an annotation-based AOP language and weaver that integrates support for these three features. The benefits of the proposed features are illustrated with concrete examples.

  1. Development of support tools for efficient construction of dynamic simulation program for engineering systems

    International Nuclear Information System (INIS)

    Gofuku, Akio

    1993-01-01

    In this study, two support tools are developed for construction of a dynamic simulation program for engineering systems (especially nuclear systems) by combining software modules. These are (1) a sub-system to support the module selection suitable for dynamic simulation and (2) a graphical user interface to support visual construction of simulation programs. The support tools are designed to be independent on the conception of software modules (data communication methods between modules). In the module selection sub-system of item 1, a module is characterized beforehand by keywords for several criteria. The similarity between the characteristic of requested module by users and that of registered modules in the module library is estimated by a weighted average of similarity indexes for criteria. In the module selection sub-system, the weights are flexibly extracted from users by applying the analytic hierarchy process. The graphical user interface helps users to specify both calling order of modules and data transfer between two modules. The availability of the support tools is evaluated by several sample problems of module selection and dynamic simulation model construction. The support tools will be a strong tool for the efficient usage of software modules. (author)

  2. Ongoing development of digital radiotherapy plan review tools

    International Nuclear Information System (INIS)

    Ebert, M.A.; Hatton, J.; Cornes, D.

    2011-01-01

    Full text: To describe ongoing development of software to support the review of radiotherapy treatment planning system (TPS) data. The 'SWAN' software program was conceived in 2000 and initially developed for the RADAR (TROG 03.04) prostate radiotherapy trial. Validation of the SWAN program has been occurring via implementation by TROG in support of multiple clinical trials. Development has continued and the SWAN software program is now supported by modular components which comprise the 'SW AN system'. This provides a comprehensive set of tools for the review, analysis and archive of TPS exports. The SWAN system has now been used in support of over 20 radiotherapy trials and to review the plans of over 2,000 trial participants. The use of the system for the RADAR trial is now culminating in the derivation of dose-outcomes indices for prostate treatment toxicity. Newly developed SWAN tools include enhanced remote data archive/retrieval, display of dose in both relative and absolute modes, and interfacing to a Matlab-based add-on ('VAST') that allows quantitative analysis of delineated volumes including regional overlap statistics for multi-observer studies. Efforts are continuing to develop the SWAN system in the context of international collaboration aimed at harmonising the quality-assurance activities of collaborative trials groups. Tools such as the SWAN system are essential for ensuring the collection of accurate and reliable evidence to guide future radiotherapy treatments. One of the principal challenges of developing such a tool is establishing a development path that will ensure its validity and applicability well into the future.

  3. National Energy Audit Tool for Multifamily Buildings Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Malhotra, Mini [ORNL; MacDonald, Michael [Sentech, Inc.; Accawi, Gina K [ORNL; New, Joshua Ryan [ORNL; Im, Piljae [ORNL

    2012-03-01

    The U.S. Department of Energy's (DOE's) Weatherization Assistance Program (WAP) enables low-income families to reduce their energy costs by providing funds to make their homes more energy efficient. In addition, the program funds Weatherization Training and Technical Assistance (T and TA) activities to support a range of program operations. These activities include measuring and documenting performance, monitoring programs, promoting advanced techniques and collaborations to further improve program effectiveness, and training, including developing tools and information resources. The T and TA plan outlines the tasks, activities, and milestones to support the weatherization network with the program implementation ramp up efforts. Weatherization of multifamily buildings has been recognized as an effective way to ramp up weatherization efforts. To support this effort, the 2009 National Weatherization T and TA plan includes the task of expanding the functionality of the Weatherization Assistant, a DOE-sponsored family of energy audit computer programs, to perform audits for large and small multifamily buildings This report describes the planning effort for a new multifamily energy audit tool for DOE's WAP. The functionality of the Weatherization Assistant is being expanded to also perform energy audits of small multifamily and large multifamily buildings. The process covers an assessment of needs that includes input from national experts during two national Web conferences. The assessment of needs is then translated into capability and performance descriptions for the proposed new multifamily energy audit, with some description of what might or should be provided in the new tool. The assessment of needs is combined with our best judgment to lay out a strategy for development of the multifamily tool that proceeds in stages, with features of an initial tool (version 1) and a more capable version 2 handled with currently available resources. Additional

  4. An Analytic Approach to Developing Transport Threshold Models of Neoclassical Tearing Modes in Tokamaks

    International Nuclear Information System (INIS)

    Mikhailovskii, A.B.; Shirokov, M.S.; Konovalov, S.V.; Tsypin, V.S.

    2005-01-01

    Transport threshold models of neoclassical tearing modes in tokamaks are investigated analytically. An analysis is made of the competition between strong transverse heat transport, on the one hand, and longitudinal heat transport, longitudinal heat convection, longitudinal inertial transport, and rotational transport, on the other hand, which leads to the establishment of the perturbed temperature profile in magnetic islands. It is shown that, in all these cases, the temperature profile can be found analytically by using rigorous solutions to the heat conduction equation in the near and far regions of a chain of magnetic islands and then by matching these solutions. Analytic expressions for the temperature profile are used to calculate the contribution of the bootstrap current to the generalized Rutherford equation for the island width evolution with the aim of constructing particular transport threshold models of neoclassical tearing modes. Four transport threshold models, differing in the underlying competing mechanisms, are analyzed: collisional, convective, inertial, and rotational models. The collisional model constructed analytically is shown to coincide exactly with that calculated numerically; the reason is that the analytical temperature profile turns out to be the same as the numerical profile. The results obtained can be useful in developing the next generation of general threshold models. The first steps toward such models have already been made

  5. Analytical quality assurance procedures developed for the IAEA's Reference Asian Man Project (Phase 2)

    International Nuclear Information System (INIS)

    Kawamura, H.; Parr, R.M.; Dang, H.S.; Tian, W.; Barnes, R.M.; Iyengar, G.V.

    2000-01-01

    Analytical quality assurance procedures adopted for use in the IAEA Co-ordinated Research Project on Ingestion and Organ Content of Trace Elements of Importance in Radiological Protection are designed to ensure comparability of the analytical results for Cs, I, Sr, Th, U and other elements in human tissues and diets collected and analysed in nine participating countries. The main analytical techniques are NAA and ICP-MS. For sample preparation, all participants are using identical food blenders which have been centrally supplied after testing for contamination. For quality control of the analyses, six NIST SRMs covering a range of matrices with certified and reference values for the elements of interest have been distributed. A new Japanese reference diet material has also been developed. These quality assurance procedures are summarized here and new data are presented for Cs, I, Sr, Th and U in the NIST SRMs. (author)

  6. Development of a site analysis tool for distributed wind projects

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, Shawn [The Cadmus Group, Inc., Waltham MA (United States)

    2012-02-28

    The Cadmus Group, Inc., in collaboration with the National Renewable Energy Laboratory (NREL) and Encraft, was awarded a grant from the Department of Energy (DOE) to develop a site analysis tool for distributed wind technologies. As the principal investigator for this project, Mr. Shawn Shaw was responsible for overall project management, direction, and technical approach. The product resulting from this project is the Distributed Wind Site Analysis Tool (DSAT), a software tool for analyzing proposed sites for distributed wind technology (DWT) systems. This user-friendly tool supports the long-term growth and stability of the DWT market by providing reliable, realistic estimates of site and system energy output and feasibility. DSAT-which is accessible online and requires no purchase or download of software-is available in two account types; Standard: This free account allows the user to analyze a limited number of sites and to produce a system performance report for each; and Professional: For a small annual fee users can analyze an unlimited number of sites, produce system performance reports, and generate other customizable reports containing key information such as visual influence and wind resources. The tool’s interactive maps allow users to create site models that incorporate the obstructions and terrain types present. Users can generate site reports immediately after entering the requisite site information. Ideally, this tool also educates users regarding good site selection and effective evaluation practices.

  7. DIDADTIC TOOLS FOR THE STUDENTS’ ALGORITHMIC THINKING DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    T. P. Pushkaryeva

    2017-01-01

    Full Text Available Introduction. Modern engineers must possess high potential of cognitive abilities, in particular, the algorithmic thinking (AT. In this regard, the training of future experts (university graduates of technical specialities has to provide the knowledge of principles and ways of designing of various algorithms, abilities to analyze them, and to choose the most optimal variants for engineering activity implementation. For full formation of AT skills it is necessary to consider all channels of psychological perception and cogitative processing of educational information: visual, auditory, and kinesthetic.The aim of the present research is theoretical basis of design, development and use of resources for successful development of AT during the educational process of training in programming.Methodology and research methods. Methodology of the research involves the basic thesis of cognitive psychology and information approach while organizing the educational process. The research used methods: analysis; modeling of cognitive processes; designing training tools that take into account the mentality and peculiarities of information perception; diagnostic efficiency of the didactic tools. Results. The three-level model for future engineers training in programming aimed at development of AT skills was developed. The model includes three components: aesthetic, simulative, and conceptual. Stages to mastering a new discipline are allocated. It is proved that for development of AT skills when training in programming it is necessary to use kinesthetic tools at the stage of mental algorithmic maps formation; algorithmic animation and algorithmic mental maps at the stage of algorithmic model and conceptual images formation. Kinesthetic tools for development of students’ AT skills when training in algorithmization and programming are designed. Using of kinesthetic training simulators in educational process provide the effective development of algorithmic style of

  8. Advanced Vibration Analysis Tool Developed for Robust Engine Rotor Designs

    Science.gov (United States)

    Min, James B.

    2005-01-01

    The primary objective of this research program is to develop vibration analysis tools, design tools, and design strategies to significantly improve the safety and robustness of turbine engine rotors. Bladed disks in turbine engines always feature small, random blade-to-blade differences, or mistuning. Mistuning can lead to a dramatic increase in blade forced-response amplitudes and stresses. Ultimately, this results in high-cycle fatigue, which is a major safety and cost concern. In this research program, the necessary steps will be taken to transform a state-of-the-art vibration analysis tool, the Turbo- Reduce forced-response prediction code, into an effective design tool by enhancing and extending the underlying modeling and analysis methods. Furthermore, novel techniques will be developed to assess the safety of a given design. In particular, a procedure will be established for using natural-frequency curve veerings to identify ranges of operating conditions (rotational speeds and engine orders) in which there is a great risk that the rotor blades will suffer high stresses. This work also will aid statistical studies of the forced response by reducing the necessary number of simulations. Finally, new strategies for improving the design of rotors will be pursued.

  9. Pilot evaluation of a continuing professional development tool for developing leadership skills.

    Science.gov (United States)

    Patterson, Brandon J; Chang, Elizabeth H; Witry, Matthew J; Garza, Oscar W; Trewet, CoraLynn B

    2013-01-01

    Strategies are needed to assure essential nonclinical competencies, such as leadership, can be gained using a continuing professional development (CPD) framework. The objective of this study was to explore student pharmacists' utilization and perceived effectiveness of a CPD tool for leadership development in an elective course. Students completed 2 CPD cycles during a semester-long leadership elective using a CPD tool. A questionnaire was used to measure students' perceptions of utility, self-efficacy, and satisfaction in completing CPD cycles when using a tool to aid in this process. The CPD tool was completed twice by 7 students. On average, students spent nearly 5 hours per CPD cycle. More than half (57.1%) scored themselves as successful or very successful in achieving their learning plans, and most (71.4%) found the tool somewhat useful in developing their leadership skills. Some perceived that the tool provided a systematic way to engage in leadership development, whereas others found it difficult to use. In this pilot study, most student pharmacists successfully achieved a leadership development plan and found the CPD tool useful. Providing students with more guidance may help facilitate use and effectiveness of CPD tools. There is a need to continue to develop and refine tools that assist in the CPD of pharmacy practitioners at all levels. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Polar Bears or People?: How Framing Can Provide a Useful Analytic Tool to Understand & Improve Climate Change Communication in Classrooms

    Science.gov (United States)

    Busch, K. C.

    2014-12-01

    Not only will young adults bear the brunt of climate change's effects, they are also the ones who will be required to take action - to mitigate and to adapt. The Next Generation Science Standards include climate change, ensuring the topic will be covered in U.S. science classrooms in the near future. Additionally, school is a primary source of information about climate change for young adults. The larger question, though, is how can the teaching of climate change be done in such a way as to ascribe agency - a willingness to act - to students? Framing - as both a theory and an analytic method - has been used to understand how language in the media can affect the audience's intention to act. Frames function as a two-way filter, affecting both the message sent and the message received. This study adapted both the theory and the analytic methods of framing, applying them to teachers in the classroom to answer the research question: How do teachers frame climate change in the classroom? To answer this question, twenty-five lessons from seven teachers were analyzed using semiotic discourse analysis methods. It was found that the teachers' frames overlapped to form two distinct discourses: a Science Discourse and a Social Discourse. The Science Discourse, which was dominant, can be summarized as: Climate change is a current scientific problem that will have profound global effects on the Earth's physical systems. The Social Discourse, used much less often, can be summarized as: Climate change is a future social issue because it will have negative impacts at the local level on people. While it may not be surprising that the Science Discourse was most often heard in these science classrooms, it is possibly problematic if it were the only discourse used. The research literature on framing indicates that the frames found in the Science Discourse - global scale, scientific statistics and facts, and impact on the Earth's systems - are not likely to inspire action-taking. This

  11. The National Shipbuilding Research Program. Development of a Quick TBT Analytical Method

    Science.gov (United States)

    2000-08-16

    Development of a Quick TBT Analytical Method 09/25/2000 Page 3 of 38 Executive Summary Concern about the toxic effect of tributyltin have caused the...Antifouling Paints on the Environment Tributyl tin ( TBT ) has been shown to be highly toxic to certain aquatic organisms at concentrations measured in the...paints, developed in the 1960s, contains the organotin tributyltin ( TBT ), which has been proven to cause deformations in oysters and sex changes in

  12. Examination of fast reactor fuels, FBR analytical quality assurance standards and methods, and analytical methods development: irradiation tests. Progress report, April 1--June 30, 1976, and FY 1976

    International Nuclear Information System (INIS)

    Baker, R.D.

    1976-08-01

    Characterization of unirradiated and irradiated LMFBR fuels by analytical chemistry methods will continue, and additional methods will be modified and mechanized for hot cell application. Macro- and microexaminations will be made on fuel and cladding using the shielded electron microprobe, emission spectrograph, radiochemistry, gamma scanner, mass spectrometers, and other analytical facilities. New capabilities will be developed in gamma scanning, analyses to assess spatial distributions of fuel and fission products, mass spectrometric measurements of burnup and fission gas constituents and other chemical analyses. Microstructural analyses of unirradiated and irradiated materials will continue using optical and electron microscopy and autoradiographic and x-ray techniques. Analytical quality assurance standards tasks are designed to assure the quality of the chemical characterizations necessary to evaluate reactor components relative to specifications. Tasks include: (1) the preparation and distribution of calibration materials and quality control samples for use in quality assurance surveillance programs, (2) the development of and the guidance in the use of quality assurance programs for sampling and analysis, (3) the development of improved methods of analysis, and (4) the preparation of continuously updated analytical method manuals. Reliable analytical methods development for the measurement of burnup, oxygen-to-metal (O/M) ratio, and various gases in irradiated fuels is described

  13. Development of tools for automatic generation of PLC code

    CERN Document Server

    Koutli, Maria; Rochez, Jacques

    This Master thesis was performed at CERN and more specifically in the EN-ICE-PLC section. The Thesis describes the integration of two PLC platforms, that are based on CODESYS development tool, to the CERN defined industrial framework, UNICOS. CODESYS is a development tool for PLC programming, based on IEC 61131-3 standard, and is adopted by many PLC manufacturers. The two PLC development environments are, the SoMachine from Schneider and the TwinCAT from Beckhoff. The two CODESYS compatible PLCs, should be controlled by the SCADA system of Siemens, WinCC OA. The framework includes a library of Function Blocks (objects) for the PLC programs and a software for automatic generation of the PLC code based on this library, called UAB. The integration aimed to give a solution that is shared by both PLC platforms and was based on the PLCOpen XML scheme. The developed tools were demonstrated by creating a control application for both PLC environments and testing of the behavior of the code of the library.

  14. Development of JOYO Plant Operation Management Expert Tool (JOYPET)

    International Nuclear Information System (INIS)

    Michino, Masanobu; Terano, Toshihiro; Hanawa, Mikio; Aoki, Hiroshi; Okubo, Toshiyuki

    2000-03-01

    The Operation and Maintenance Support Systems for JOYO are being developed, with the aim of ensuring the stable and safe operation of JOYO and improving operational reliability of future FBR plants. Plant Operation Management Expert Tool named JOYPET had been developed as one of the Operation and Maintenance Support Systems, which helps plant operation management. The following functions were developed and applied. (1) Papers management (Plant status management) function for maintenance activities, (2) Isolation management support function for plant operation, (3) Automatically drawing function of plant operation schedule, (4) Isolation judgment function for plant operation. By use this system, the plant management of JOYO was able to improved reliability and reduced manpower. (author)

  15. Developing electronic cooperation tools: a case from norwegian health care.

    Science.gov (United States)

    Larsen, Eli; Mydske, Per Kristen

    2013-06-19

    Many countries aim to create electronic cooperational tools in health care, but the progress is rather slow. The study aimed to uncover how the authoritys' financing policies influence the development of electronic cooperational tools within public health care. An interpretative approach was used in this study. We performed 30 semistructured interviews with vendors, policy makers, and public authorities. Additionally, we conducted an extensive documentation study and participated in 18 workshops concerning information and communication technology (ICT) in Norwegian health care. We found that the interorganizational communication in sectors like health care, that have undergone an independent development of their internal information infrastructure would find it difficult to create electronic services that interconnect the organizations because such connections would affect all interconnected organizations within the heterogenic structure. The organizations would, to a large extent, depend on new functionality in existing information systems. Electronic patient records play a central role in all parts of the health care sector and therefore dependence is established to the information systems and theirs vendors. The Norwegian government authorities, which run more than 80% of the Norwegian health care, have not taken extraordinary steps to compensate for this dependency-the government's political philosophy is that each health care institution should pay for further electronic patient record development. However, cooperational tools are complex due to the number of players involved and the way they are intertwined with the overall workflow. The customers are not able to buy new functionalities on the drawing table, while the electronic patient record vendors are not willing to take the economic risk in developing cooperational tools. Thus, the market mechanisms in the domain are challenged. We also found that public projects that were only financed for the first

  16. The teaching portfolio as a professional development tool for anaesthetists.

    Science.gov (United States)

    Sidhu, N S

    2015-05-01

    A teaching portfolio (TP) is a document containing a factual description of a teacher's teaching strengths and accomplishments, allowing clinicians to display them for examination by others. The primary aim of a TP is to improve quality of teaching by providing a structure for self-reflection, which in turn aids professional development in medical education. Contents typically include a personal statement on teaching, an overview of teaching accomplishments and activities, feedback from colleagues and learners, a reflective component and some examples of teaching material. Electronic portfolios are more portable and flexible compared to paper portfolios. Clinicians gain the most benefit from a TP when it is used as a tool for self-reflection of their teaching practice and not merely as a list of activities and achievements. This article explains why and how anaesthetists might use a TP as a tool for professional development in medical education.

  17. Oral Development for LSP via Open Source Tools

    Directory of Open Access Journals (Sweden)

    Alejandro Curado Fuentes

    2015-11-01

    Full Text Available For the development of oral abilities in LSP, few computer-based teaching and learning resources have actually focused intensively on web-based listening and speaking. Many more do on reading, writing, vocabulary and grammatical activities. Our aim in this paper is to approach oral communication in the online environment of Moodle by striving to make it suitable for a learning project which incorporates oral skills. The paper describes a blended process in which both individual and collaborative learning strategies can be combined and exploited through the implementation of specific tools and resources which may go hand in hand with traditional face-to-face conversational classes. The challenge with this new perspective is, ultimately, to provide effective tools for oral LSP development in an apparently writing skill-focused medium.

  18. Development of IFC based fire safety assesment tools

    DEFF Research Database (Denmark)

    Taciuc, Anca; Karlshøj, Jan; Dederichs, Anne

    2016-01-01

    Due to the impact that the fire safety design has on the building's layout and on other complementary systems, as installations, it is important during the conceptual design stage to evaluate continuously the safety level in the building. In case that the task is carried out too late, additional...... changes need to be implemented, involving supplementary work and costs with negative impact on the client. The aim of this project is to create a set of automatic compliance checking rules for prescriptive design and to develop a web application tool for performance based design that retrieves data from...... Building Information Models (BIM) to evacuate the safety level in the building during the conceptual design stage. The findings show that the developed tools can be useful in AEC industry. Integrating BIM from conceptual design stage for analyzing the fire safety level can ensure precision in further...

  19. Development and Validation of a Family Meeting Assessment Tool (FMAT).

    Science.gov (United States)

    Hagiwara, Yuya; Healy, Jennifer; Lee, Shuko; Ross, Jeanette; Fischer, Dixie; Sanchez-Reilly, Sandra

    2018-01-01

    A cornerstone procedure in Palliative Medicine is to perform family meetings. Learning how to lead a family meeting is an important skill for physicians and others who care for patients with serious illnesses and their families. There is limited evidence on how to assess best practice behaviors during end-of-life family meetings. Our aim was to develop and validate an observational tool to assess trainees' ability to lead a simulated end-of-life family meeting. Building on evidence from published studies and accrediting agency guidelines, an expert panel at our institution developed the Family Meeting Assessment Tool. All fourth-year medical students (MS4) and eight geriatric and palliative medicine fellows (GPFs) were invited to participate in a Family Meeting Objective Structured Clinical Examination, where each trainee assumed the physician role leading a complex family meeting. Two evaluators observed and rated randomly chosen students' performances using the Family Meeting Assessment Tool during the examination. Inter-rater reliability was measured using percent agreement. Internal consistency was measured using Cronbach α. A total of 141 trainees (MS4 = 133 and GPF = 8) and 26 interdisciplinary evaluators participated in the study. Internal reliability (Cronbach α) of the tool was 0.85. Number of trainees rated by two evaluators was 210 (MS4 = 202 and GPF = 8). Rater agreement was 84%. Composite scores, on average, were significantly higher for fellows than for medical students (P < 0.001). Expert-based content, high inter-rater reliability, good internal consistency, and ability to predict educational level provided initial evidence for construct validity for this novel assessment tool. Copyright © 2017 American Academy of Hospice and Palliative Medicine. All rights reserved.

  20. MOOCs as a Professional Development Tool for Librarians

    Directory of Open Access Journals (Sweden)

    Meghan Ecclestone

    2013-11-01

    Full Text Available This article explores how reference and instructional librarians taking over new areas of subject responsibility can develop professional expertise using new eLearning tools called MOOCs. MOOCs – Massive Open Online Courses – are a new online learning model that offers free higher education courses to anyone with an Internet connection and a keen interest to learn. As MOOCs proliferate, librarians have the opportunity to leverage this technology to improve their professional skills.

  1. EUV source development for high-volume chip manufacturing tools

    Science.gov (United States)

    Stamm, Uwe; Yoshioka, Masaki; Kleinschmidt, Jürgen; Ziener, Christian; Schriever, Guido; Schürmann, Max C.; Hergenhan, Guido; Borisov, Vladimir M.

    2007-03-01

    Xenon-fueled gas discharge produced plasma (DPP) sources were integrated into Micro Exposure Tools already in 2004. Operation of these tools in a research environment gave early learning for the development of EUV sources for Alpha and Beta-Tools. Further experiments with these sources were performed for basic understanding on EUV source technology and limits, especially the achievable power and reliability. The intermediate focus power of Alpha-Tool sources under development is measured to values above 10 W. Debris mitigation schemes were successfully integrated into the sources leading to reasonable collector mirror lifetimes with target of 10 billion pulses due to the effective debris flux reduction. Source collector mirrors, which withstand the radiation and temperature load of Xenon-fueled sources, have been developed in cooperation with MediaLario Technologies to support intermediate focus power well above 10 W. To fulfill the requirements for High Volume chip Manufacturing (HVM) applications, a new concept for HVM EUV sources with higher efficiency has been developed at XTREME technologies. The discharge produced plasma (DPP) source concept combines the use of rotating disk electrodes (RDE) with laser exited droplet targets. The source concept is called laser assisted droplet RDE source. The fuel of these sources has been selected to be Tin. The conversion efficiency achieved with the laser assisted droplet RDE source is 2-3x higher compared to Xenon. Very high pulse energies well above 200 mJ / 2π sr have been measured with first prototypes of the laser assisted droplet RDE source. If it is possible to maintain these high pulse energies at higher repetition rates a 10 kHz EUV source could deliver 2000 W / 2π sr. According to the first experimental data the new concept is expected to be scalable to an intermediate focus power on the 300 W level.

  2. Developing security tools of WSN and WBAN networks applications

    CERN Document Server

    A M El-Bendary, Mohsen

    2015-01-01

    This book focuses on two of the most rapidly developing areas in wireless technology (WT) applications, namely, wireless sensors networks (WSNs) and wireless body area networks (WBANs). These networks can be considered smart applications of the recent WT revolutions. The book presents various security tools and scenarios for the proposed enhanced-security of WSNs, which are supplemented with numerous computer simulations. In the computer simulation section, WSN modeling is addressed using MATLAB programming language.

  3. NIR spectroscopy as a process analytical technology (PAT) tool for monitoring and understanding of a hydrolysis process.

    Science.gov (United States)

    Wu, Zhisheng; Peng, Yanfang; Chen, Wei; Xu, Bing; Ma, Qun; Shi, Xinyuan; Qiao, Yanjiang

    2013-06-01

    The use of near infrared spectroscopy was investigated as a process analytical technology to monitor the amino acids concentration profile during hydrolysis process of Cornu Bubali. A protocol was followed, including outlier selection using relationship plot of residuals versus the leverage level, calibration models using interval partial least squares and synergy interval partial least squares (SiPLS). A strategy of four robust root mean square error of predictions (RMSEP) values have been developed to assess calibration models by means of the desirability index. Furthermore, multivariate quantification limits (MQL) values of the optimum model were determined using two types of error. The SiPLS(3) models for L-proline, L-tyrosine, L-valine, L-phenylalanine and L-lysine provided excellent accuracies with RMSEP values of 0.0915 mg/mL, 0.1605 mg/mL, 0.0515 mg/mL, 0.0586 mg/mL and 0.0613 mg/mL, respectively. The MQL ranged from 90 ppm to 810 ppm, which confirmed that these models can be suitable for most applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. On transform coding tools under development for VP10

    Science.gov (United States)

    Parker, Sarah; Chen, Yue; Han, Jingning; Liu, Zoe; Mukherjee, Debargha; Su, Hui; Wang, Yongzhe; Bankoski, Jim; Li, Shunyao

    2016-09-01

    Google started the WebM Project in 2010 to develop open source, royaltyfree video codecs designed specifically for media on the Web. The second generation codec released by the WebM project, VP9, is currently served by YouTube, and enjoys billions of views per day. Realizing the need for even greater compression efficiency to cope with the growing demand for video on the web, the WebM team embarked on an ambitious project to develop a next edition codec, VP10, that achieves at least a generational improvement in coding efficiency over VP9. Starting from VP9, a set of new experimental coding tools have already been added to VP10 to achieve decent coding gains. Subsequently, Google joined a consortium of major tech companies called the Alliance for Open Media to jointly develop a new codec AV1. As a result, the VP10 effort is largely expected to merge with AV1. In this paper, we focus primarily on new tools in VP10 that improve coding of the prediction residue using transform coding techniques. Specifically, we describe tools that increase the flexibility of available transforms, allowing the codec to handle a more diverse range or residue structures. Results are presented on a standard test set.

  5. Using an evaluative tool to develop effective mathscasts

    Science.gov (United States)

    Galligan, Linda; Hobohm, Carola; Peake, Katherine

    2017-09-01

    This study is situated in a course designed for both on-campus and online pre-service and in-service teachers, where student-created mathscasts provide a way for university lecturers to assess students' quality of teaching, and understanding of mathematics. Teachers and pre-service teachers, in a university course with 90% online enrolment, were asked to create mathscasts to explain mathematics concepts at middle school level. This paper describes the process of developing and refining a tool for the creation and evaluation of quality student-produced mathscasts. The study then investigates the usefulness of the tool within the context of pedagogy and mathematical understanding. Despite an abundance of mathscasts already available on the web, there is merit in creating mathscasts, not only as a tool for teaching, but also as a means of learning by doing. The premise for creating student-produced mathscasts was to capture the creators' mathematical understanding and pedagogical approach to teaching a mathematical concept, which were then peer-assessed and graded. The analysis included surveys, practice mathscasts with peer- and self-reviews, and students' final assessed mathscasts. The results indicate that the use of the evaluative tool resulted in an improvement in quality of student-created mathscasts and critiques thereof. The paper concludes with a discussion on future directions of student-produced mathscasts.

  6. Development and content validation of the power mobility training tool.

    Science.gov (United States)

    Kenyon, Lisa K; Farris, John P; Cain, Brett; King, Emily; VandenBerg, Ashley

    2018-01-01

    This paper outlines the development and content validation of the power mobility training tool (PMTT), an observational tool designed to assist therapists in developing power mobility training programs for children who have multiple, severe impairments. Initial items on the PMTT were developed based on a literature review and in consultation with therapists experienced in the use of power mobility. Items were trialled in clinical settings, reviewed, and refined. Items were then operationalized and an administration manual detailing scoring for each item was created. Qualitative and quantitative methods were used to establish content validity via a 15 member, international expert panel. The content validity ratio (CVR) was determined for each possible item. Of the 19 original items, 10 achieved minimum required CVR values and were included in the final version of the PMTT. Items related to manoeuvring a power mobility device were merged and an item related to the number of switches used concurrently to operate a power mobility device were added to the PMTT. The PMTT may assist therapists in developing training programs that facilitate the acquisition of beginning power mobility skills in children who have multiple, severe impairments. Implications for Rehabilitation The Power Mobility Training Tool (PMTT) was developed to help guide the development of power mobility intervention programs for children who have multiple, severe impairments. The PMTT can be used with children who access a power mobility device using either a joystick or a switch. Therapists who have limited experience with power mobility may find the PMTT to be helpful in setting up and conducting power mobility training interventions as a feasible aspect of a plan of care for children who have multiple, severe impairments.

  7. Development and validation of a premature ejaculation diagnostic tool.

    Science.gov (United States)

    Symonds, Tara; Perelman, Michael A; Althof, Stanley; Giuliano, François; Martin, Mona; May, Kathryn; Abraham, Lucy; Crossland, Anna; Morris, Mark

    2007-08-01

    Diagnosis of premature ejaculation (PE) for clinical trial purposes has typically relied on intravaginal ejaculation latency time (IELT) for entry, but this parameter does not capture the multidimensional nature of PE. Therefore, the aim was to develop a brief, multidimensional, psychometrically validated instrument for diagnosing PE status. The questionnaire development involved three stages: (1) Five focus groups and six individual interviews were conducted to develop the content; (2) psychometric validation using three different groups of men; and (3) generation of a scoring system. For psychometric validation/scoring system development, data was collected from (1) men with PE based on clinician diagnosis, using DSM-IV-TR, who also had IELTs or =11 PE. The development and validation of this new PE diagnostic tool has resulted in a new, user-friendly, and brief self-report questionnaire for use in clinical trials to diagnose PE.

  8. Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for a continuous granulation-drying-milling process.

    Science.gov (United States)

    Kumar, Vijay; Taylor, Michael K; Mehrotra, Amit; Stagner, William C

    2013-06-01

    Focused beam reflectance measurement (FBRM) was used as a process analytical technology tool to perform inline real-time particle size analysis of a proprietary granulation manufactured using a continuous twin-screw granulation-drying-milling process. A significant relationship between D20, D50, and D80 length-weighted chord length and sieve particle size was observed with a p value of 0.05).

  9. Developing a practical evaluation tool for preceptor use.

    Science.gov (United States)

    Walsh, Catherine M; Seldomridge, Lisa A; Badros, Karen K

    2008-01-01

    After years of dissatisfaction with existing instruments, a tool for preceptors to evaluate an undergraduate student's clinical performance was developed, with preceptors' input in its construction. A 2-year pilot evaluation revealed notable problems including excessively high preceptor ratings and significant disparities between faculty and preceptor ratings. Further revisions were made, reducing indicators to those which the preceptors can actually evaluate on an everyday basis and developing a rubric. Additional recommendations to bolster the quality of ratings are improving orientation and guidance of preceptors and modifying procedures for giving feedback.

  10. Analytical Method Development for the Determination of Α-Endosulfan and Bifenthrin Pesticide Residues in Tea

    Directory of Open Access Journals (Sweden)

    Dyah Styarini

    2014-03-01

    Full Text Available The development of analytical method for the determination of α-endosulfan and bifenthrin residues in tea has been done. The complex matrices and also the pigment were the challenge in doing quantification of the pesticide residues in tea matrices. In order to get appropriate analysis method for the determination of pesticide residues in tea, the modification was done in the analytical method for the determination of organochlorine multiresidue in non fat matrices: seasoning and spicy that is published by Directorate General of Food Crops, Directorate of Food Plant Protection. The modification was done particularly in clean-up step to remove the interferences from the extract of tea matrices such as the pigment that usually interfere the measurement with Gas Chromatography (GC. The result showed that the MDL value for both analytes were 0.5 ng/g that were much lower than MRLs. The percent recovery obtained from the method was 78.58 and 90.19% for α-endosulfan and bifenthrin, respectively. The precision of the analysis method for both analytes were good since the % RSD values were below than the Horwitz’s value that was 19.18% at spiking level concentration of 300 ng/g.

  11. Development of a Boundary Layer Property Interpolation Tool in Support of Orbiter Return To Flight

    Science.gov (United States)

    Greene, Francis A.; Hamilton, H. Harris

    2006-01-01

    A new tool was developed to predict the boundary layer quantities required by several physics-based predictive/analytic methods that assess damaged Orbiter tile. This new tool, the Boundary Layer Property Prediction (BLPROP) tool, supplies boundary layer values used in correlations that determine boundary layer transition onset and surface heating-rate augmentation/attenuation factors inside tile gouges (i.e. cavities). BLPROP interpolates through a database of computed solutions and provides boundary layer and wall data (delta, theta, Re(sub theta)/M(sub e), Re(sub theta)/M(sub e), Re(sub theta), P(sub w), and q(sub w)) based on user input surface location and free stream conditions. Surface locations are limited to the Orbiter s windward surface. Constructed using predictions from an inviscid w/boundary-layer method and benchmark viscous CFD, the computed database covers the hypersonic continuum flight regime based on two reference flight trajectories. First-order one-dimensional Lagrange interpolation accounts for Mach number and angle-of-attack variations, whereas non-dimensional normalization accounts for differences between the reference and input Reynolds number. Employing the same computational methods used to construct the database, solutions at other trajectory points taken from previous STS flights were computed: these results validate the BLPROP algorithm. Percentage differences between interpolated and computed values are presented and are used to establish the level of uncertainty of the new tool.

  12. The development of a practical tool for risk assessment of manual work – the HAT-tool

    NARCIS (Netherlands)

    Kraker, H. de; Douwes, M.

    2008-01-01

    For the Dutch Ministry of Social Affairs and Employment we developed a tool to assess the risks of developing complaints of the arm, neck or shoulders during manual work. The tool was developed for every type of organization and is easy to use, does not require measurements other than time and can

  13. Sustainable Urban Development: Spatial Analyses as Novel Tools for Planning a Universally Designed City

    Directory of Open Access Journals (Sweden)

    Joanna Borowczyk

    2018-05-01

    Full Text Available The aim of the research was to analyze the “design for all” concept as a key strategy for creating social sustainability. The paper attempts to answer the question: how can universal design contribute to the rational development of the city space? The author has taken part in participatory experiments. The research took into account various criteria, including the level of the city space’s adaptation to the needs and capabilities of persons with different disabilities. Analyses included qualitative studies concerning the possibilities of developing the social capital as well as creating and preserving a cohesive social structure. The analytic process allowed determining the means of raising the quality of urban planning. Finding effective and reliable analytical tools enabling the development of healthy cities which are compatible with the principles of sustainability could become both a great chance and a great challenge for urban planners. Transition from the microplanning to the macroplanning scale and following the principles of universal design at the stage of the formation of urban concepts using spatiotemporal modelling methods will lead to the creation of harmonious accessible spaces adjusted to the needs of present and future users, which will generate sustainable development and lead to the healing of a city.

  14. Developments in the Tools and Methodologies of Synthetic Biology

    Science.gov (United States)

    Kelwick, Richard; MacDonald, James T.; Webb, Alexander J.; Freemont, Paul

    2014-01-01

    Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to engineer. In order to address these fundamental challenges, synthetic biology is aiming to unify a “body of knowledge” from several foundational scientific fields, within the context of a set of engineering principles. This shift in perspective is enabling synthetic biologists to address complexity, such that robust biological systems can be designed, assembled, and tested as part of a biological design cycle. The design cycle takes a forward-design approach in which a biological system is specified, modeled, analyzed, assembled, and its functionality tested. At each stage of the design cycle, an expanding repertoire of tools is being developed. In this review, we highlight several of these tools in terms of their applications and benefits to the synthetic biology community. PMID:25505788

  15. Process-Based Quality (PBQ) Tools Development; TOPICAL

    International Nuclear Information System (INIS)

    Cummins, J.L.

    2001-01-01

    The objective of this effort is to benchmark the development of process-based quality tools for application in CAD (computer-aided design) model-based applications. The processes of interest are design, manufacturing, and quality process applications. A study was commissioned addressing the impact, current technologies, and known problem areas in application of 3D MCAD (3-dimensional mechanical computer-aided design) models and model integrity on downstream manufacturing and quality processes. The downstream manufacturing and product quality processes are profoundly influenced and dependent on model quality and modeling process integrity. The goal is to illustrate and expedite the modeling and downstream model-based technologies for available or conceptual methods and tools to achieve maximum economic advantage and advance process-based quality concepts

  16. Developments in the tools and methodologies of synthetic biology

    Directory of Open Access Journals (Sweden)

    Richard eKelwick

    2014-11-01

    Full Text Available Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices or systems. However, biological systems are generally complex and unpredictable and are therefore intrinsically difficult to engineer. In order to address these fundamental challenges, synthetic biology is aiming to unify a ‘body of knowledge’ from several foundational scientific fields, within the context of a set of engineering principles. This shift in perspective is enabling synthetic biologists to address complexity, such that robust biological systems can be designed, assembled and tested as part of a biological design cycle. The design cycle takes a forward-design approach in which a biological system is specified, modeled, analyzed, assembled and its functionality tested. At each stage of the design cycle an expanding repertoire of tools is being developed. In this review we highlight several of these tools in terms of their applications and benefits to the synthetic biology community.

  17. Development Life Cycle and Tools for XML Content Models

    Energy Technology Data Exchange (ETDEWEB)

    Kulvatunyou, Boonserm [ORNL; Morris, Katherine [National Institute of Standards and Technology (NIST); Buhwan, Jeong [POSTECH University, South Korea; Goyal, Puja [National Institute of Standards and Technology (NIST)

    2004-11-01

    Many integration projects today rely on shared semantic models based on standards represented using Extensible Mark up Language (XML) technologies. Shared semantic models typically evolve and require maintenance. In addition, to promote interoperability and reduce integration costs, the shared semantics should be reused as much as possible. Semantic components must be consistent and valid in terms of agreed upon standards and guidelines. In this paper, we describe an activity model for creation, use, and maintenance of a shared semantic model that is coherent and supports efficient enterprise integration. We then use this activity model to frame our research and the development of tools to support those activities. We provide overviews of these tools primarily in the context of the W3C XML Schema. At the present, we focus our work on the W3C XML Schema as the representation of choice, due to its extensive adoption by industry.

  18. Development to requirements for a procedures software tool

    International Nuclear Information System (INIS)

    Yasutake, J.Y.; Hachiro Isoda

    1993-01-01

    In 1989, the Electric Power Research Institute (EPRI) and the Central Research Institute of the Electric Power Industry (CRIEPI) in Japan initiated a joint research program to investigate various interventions to reduce personnel errors and inefficiencies in the maintenance of nuclear power plants. This program, consisting of several interrelated projects, was initiated because of the mutual recognition of the importance of the human element in the efficient and safe operation of utilities and the continuing need to enhance personnel performance to sustain plant safety and availability. This paper summarizes one of the projects, jointly funded by EPRI and CRIEPI, to analyze the requirements for, and prepare a functional description of, a procedures software tool (PST). The primary objective of this project was to develop a description of the features and functions of a software tool that would help procedure writers to improve the quality of maintenance and testing procedures, thereby enhancing the performance of both procedure writers and maintenance personnel

  19. Requirements Document for Development of a Livermore Tomography Tools Interface

    Energy Technology Data Exchange (ETDEWEB)

    Seetho, I. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-02-09

    In this document, we outline an exercise performed at LLNL to evaluate the user interface deficits of a LLNL-developed CT reconstruction software package, Livermore Tomography Tools (LTT). We observe that a difficult-to-use command line interface and the lack of support functions compound to generate a bottleneck in the CT reconstruction process when input parameters to key functions are not well known. Through the exercise of systems engineering best practices, we generate key performance parameters for a LTT interface refresh, and specify a combination of back-end (“test-mode” functions) and front-end (graphical user interface visualization and command scripting tools) solutions to LTT’s poor user interface that aim to mitigate issues and lower costs associated with CT reconstruction using LTT. Key functional and non-functional requirements and risk mitigation strategies for the solution are outlined and discussed.

  20. A free software tool for the development of decision support systems

    Directory of Open Access Journals (Sweden)

    COLONESE, G

    2008-06-01

    Full Text Available This article describes PostGeoOlap, a free software open source tool for decision support that integrates OLAP (On-Line Analytical Processing and GIS (Geographical Information Systems. Besides describing the tool, we show how it can be used to achieve effective and low cost decision support that is adequate for small and medium companies and for small public offices.