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Sample records for ameloblastoma

  1. Ameloblastoma desmoplásico Desmoplastic ameloblastoma

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    J.L. Martínez-Lage

    2010-03-01

    Full Text Available Presentamos un caso de ameloblastoma desmoplásico en una mujer de 32 años que afecta a la región media del maxilar superior. Se describen las características específicas, tanto histológicas como clínicas, de esta variante de ameloblastoma, y se insiste en su imagen radiológica similar a la de una lesión fibroósea benigna. Se indica la misma conducta terapéutica que para el resto de los ameloblastomas intraóseos sólidos.We report a case of desmoplastic ameloblastoma in a 32 year-old female patient affecting the region half of the upper jaw. We describe the specific characteristics, both histological and clinical of this variant of ameloblastoma, insisting its radiological image similar to that of a benign fibroosseous lession. We indicate the same therapeutic conduct for the rest of the solid intraosseous ameloblastomas.

  2. Ameloblastoma in children; Ameloblastoma u dzieci

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    Korzon, M.; Popadiuk, S.; Bohdan, Z. and others [Akademia Medyczna, Gdansk (Poland)

    1993-12-31

    Two cases of ameloblastoma in 3 and 12 year old children are described. The difficulties in the diagnosis and treatment of this rare tumor of the jaws (mandibula) are presented. Only a short remission following chemotherapy was achieved in both cases. (author) 19 refs, 2 figs

  3. Malignant ameloblastoma or ameloblastic carcinoma

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    Slootweg, P.J.; Müller, H.

    1984-01-01

    The World Health Organization defines malignant ameloblastoma as a lesion exhibiting features of an ameloblastoma in primary and metastatic growths. To cases collected from the literature we have added two of our own cases in which features of an ameloblastoma were coupled with malignant behavior. I

  4. Unicystic ameloblastoma of the mandible

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    Nitin Gupta

    2011-01-01

    Full Text Available Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation unicystic ameloblastoma is a less encountered variant of the ameloblastoma and believed to be less aggressive. As this tumor shows considerable similarities with dentigerous cysts, both clinically and radiographically the biologic behaviour of this tumor group was reviewed. Moreover, recurrence of unicystic ameloblastoma may be long delayed and a long-term post-operative follow up is essential for proper management of these patients. Here we are presenting a case of unicystic ameloblastoma in a 18 year old female patient.

  5. Unicystic ameloblastoma of the mandible

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    Gupta, Nitin; Saxena, Susmita; Rathod, Vaneeta C; Aggarwal, Pooja

    2011-01-01

    Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation unicystic ameloblastoma is a less encountered variant of the ameloblastoma and believed to be less aggressive. As this tumor shows considerable similarities with dentigerous cysts, both clinically and radiographically the biologic behaviour of this tumor group was reviewed. Moreover, recurrence of unicystic ameloblastoma may be long delayed and a long-term post-operative follow up is essential for proper management of these patients. Here we are presenting a case of unicystic ameloblastoma in a 18 year old female patient. PMID:22529587

  6. Overwhelming hypercalcaemia in mandibular ameloblastoma.

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    Lo, Tom Edward Ngo; Villafuerte, Cesar Vincent; Acampado, Laura Trajano

    2014-10-17

    Ameloblastoma is considered to be a benign odontogenic tumour of epithelial in origin that is slow growing but recurrent and invasive in nature. Some of its features have been sources of debate among experts regarding its benign or malignant character. We report a case of a 20-year-old Filipino woman with right mandibular ameloblastoma presenting with overwhelming hypercalcaemia. Work ups for hypercalcaemia eventually revealed tumoral hypercalcaemia, which was initially controlled with intravenous bisphosphanate. The patient eventually underwent tumour excision and mandibular reconstruction, which totally corrected hypercalcaemia. This case will highlight the rare association of hypercalcaemia among patients with ameloblastoma.

  7. Peripheral ameloblastoma: A case report

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    Song, Ju Seop; Kim, Kyoung A; Koh, Kwang Joon [Chonbuk National Univ., Chonju (Korea, Republic of)

    2006-06-15

    Peripheral ameloblastoma is an extremely rate odontogenic soft tissue tumor with histologic characteristics similar to those of the intraosseous ameloblastoma. It appears in the gingiva and oral mucosa. And it usually does not show any bone involvement on radiographs, except for saucer shaped erosion of underlying alveolar bone. Recurrence is considered uncommon. We report a case of peripheral ameloblastoma with bone involvement. Histologically it presented with follicles and nest of tumor cells with palisading pattern. And radiographs showed the typical saucer shaped alveolar bone erosion at the distal area of right mandibular third molar. At 6-mouth follow-up after operation, no local recurrence was noted.

  8. Ameloblastoma mandibular muy agresivo

    OpenAIRE

    2008-01-01

    Se presenta una paciente de sexo femenino con diagnóstico de ameloblastoma folicular que se comportó de manera extraordinariamente agresiva, considerando este tipo histológico, con recidiva extensa que requirió cirugía radical y reconstrucción con doble colgajo libre, y que a pesar de obtener márgenes negativos, presenta una nueva y más extensa recidiva, quedando fuera del alcance quirúrgico y falleciendo 11 meses luego de la última cirugía

  9. Plexiform Unicystic Ameloblastoma: A Rare Variant of Ameloblastoma

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    Swapnil S. Deore

    2014-01-01

    Full Text Available The term plexiform unicystic ameloblastoma refers to a pattern of epithelial proliferation that has been described in cystic cavity. Because of unilocular presentation, it is commonly misdiagnosed as an odontogenic cyst. However, they may often behave clinically as biologically aggressive tumors. These tumors show high incidence of cortical perforation, tooth resorption and a high rate of recurrence after simple enucleation. This paper aims to provide an insight into this biologically distinct entity. A literature review on the topic has been added along with a case report highlighting the approach of diagnosis and management of such ameloblastomas.

  10. Tratamento cirúrgico de ameloblastoma mandibular

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    Jardim, Ellen Cristina Gaetti [UNESP; Faverani, Leonardo Peres [UNESP; Melo, Rosana Leite de; Miyahara, Glauco Issamu [UNESP; Soubhia, Ana Maria Pires; Mendonça, José Carlos Garcia de; Shinohara, Elio Hitoshi [UNESP

    2013-01-01

    Ameloblastomas are benign, invasive locally and highly recurrent. It is an odontogenic tumor, characterized by the proliferation of epithelial ameloblastic in a fibrous stroma. This paper reports a case of mandibular ameloblastoma, in patients 27 years of age without pain with developments around 4 years, with about 20 mm at its greatest extent, sessile base and surface coatings full. The treatment of choice was the surgical conservative Ameloblastomas son benignos, localmente invasivo y a...

  11. Unicystic Mural Ameloblastoma: An Unusual Case Report

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    Nagalaxmi, V.; Sangmesh, Mithare; Maloth, Kotya Naik; Kodangal, Srikanth; Chappidi, Vani; Goyal, Stuti

    2013-01-01

    Ameloblastoma is a benign odontogenic neoplasm which frequently affects the mandible. The term ameloblastoma includes several clinicoradiological and histological types. Apart from the most commonly encountered clinicopathologic models, there are few variants, whose biological profile is unknown or not elicited. Among these types, unicystic ameloblastoma is the least encountered variant of the ameloblastoma. Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic, or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation. Unicystic ameloblastoma is a less encountered variant of the ameloblastoma and is believed to be less aggressive. As this tumor shows considerable similarities with dentigerous cysts, both clinically and radiographically, the biologic behaviour of this tumor group was reviewed. Moreover, recurrence of unicystic ameloblastoma may be long delayed, and a long-term postoperative followup is essential for proper management of these patients. Here we are presenting a case of unicystic ameloblastoma in an 18-year-old female patient. PMID:23710377

  12. Unicystic Mural Ameloblastoma: An Unusual Case Report

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    V. Nagalaxmi

    2013-01-01

    Full Text Available Ameloblastoma is a benign odontogenic neoplasm which frequently affects the mandible. The term ameloblastoma includes several clinicoradiological and histological types. Apart from the most commonly encountered clinicopathologic models, there are few variants, whose biological profile is unknown or not elicited. Among these types, unicystic ameloblastoma is the least encountered variant of the ameloblastoma. Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic, or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation. Unicystic ameloblastoma is a less encountered variant of the ameloblastoma and is believed to be less aggressive. As this tumor shows considerable similarities with dentigerous cysts, both clinically and radiographically, the biologic behaviour of this tumor group was reviewed. Moreover, recurrence of unicystic ameloblastoma may be long delayed, and a long-term postoperative followup is essential for proper management of these patients. Here we are presenting a case of unicystic ameloblastoma in an 18-year-old female patient.

  13. Unicystic ameloblastoma with the presence of dentin

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    Sivapathasundharam B

    2007-01-01

    Full Text Available We present a case of unicystic ameloblastoma of the posterior mandible in a 28 year-old female, histologically showing luminal and intramural plexiform epithelial proliferation with typical dentin in the connective tissue capsule. The characteristics of hard tissue formation in ameloblastomas reported in existing literature and the possible origin of the dentin mass seen in our case are discussed.

  14. Incidence and overall survival of malignant ameloblastoma.

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    Alexandra Rizzitelli

    Full Text Available Malignant ameloblastoma, comprising metastasizing ameloblastoma and ameloblastic carcinoma, represents 1.6-2.2% of all odontogenic tumors. Due to its rare nature, malignant ameloblastoma has only been reported in the literature in small case series or case reports. Using the Surveillance, Epidemiology and End-Results (SEER database, we have performed a population-based study to determine the incidence rate and the absolute survival of malignant ameloblastoma.Using the International Classification of Diseases for Oncology (ICD-O codes 9310/3 and 9270/3, data from the SEER database were used to calculate the incidence rate and absolute survival rate of population with malignant ameloblastoma.The overall incidence rate of malignant ameloblastoma was 1.79 per 10 million person/year. The incidence rate was higher in males than females and also higher in black versus white population. The median overall survival was 17.6 years from the time of diagnosis and increasing age was associated with a statistically significant poorer survival.To our best knowledge, we report the largest population-based series of malignant ameloblastoma. The incidence rate was 1.79 per 10 million person/year and the overall survival was 17.6 years.

  15. Imaging diagnosis of ameloblastoma; Bildgebung bei Ameloblastomen

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    Esser, M.; Horger, M.; Ioanovicu, S.D.; Boesmueller, H.

    2015-10-15

    Ameloblastomas are ondontogenic tumors of the upper and lower jaw. The ameloblastomas are supposed to be benign with slow growth, but locally invasive growth is possible. Contrast agent enhanced CT seems to have the largest imaging potential to differentiate between benign and malign osteogenic processes. In general - dependent on localization, histological type and neighboring tissues - the radical resection with following plastic reconstruction seems to be the best therapeutic decision.

  16. Intraosseous ameloblastoma masquerading as exophytic growth: a case report

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    Ramachandra, Prashanth; Ramnarayan, BK; Sanjay, CJ; David, Chaya M [Dr Shyamala Reddy Dental College and Hospital, Bangalore (India); Kaul, Rachna [Dayananda Sagar College of Dental Sciences, Bangalore (India)

    2011-06-15

    Intraosseous ameloblastoma is the most common and simple type of ameloblastoma prevalent among odontogenic tumors. Clinico-radiographically intraosseous ameloblastoma presents as slow, painless swelling or expansion of the jaws and described as multilocular expansile radiolucency that occurs most frequently in mandibular molar/ramus area. This article describes a case of follicular ameloblastoma involving 45 year old male which is different from the usual presentation, which includes-exophytic growth, different location and without expansion of the cortex.

  17. Ameloblastoma: Our clinical experience with 68 cases

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    Benjamin Fomete

    2014-01-01

    Full Text Available Introduction: In this environment, previous workers have reported on the challenges of managing large sized ameloblastoma of the jaws with less than adequate facilities. The aim of this review is to present the management of 68 cases of ameloblastoma with emphasis on surgical care. Materials and Methods: Retrospective survey of case notes of patients with histopathologic diagnosis of ameloblastoma (using the criteria of Barnes et al., 2005 seen between January 2006 and August 2010 at the Maxillofacial Unit, Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria was undertaken. Data collected includes histopathological diagnosis, age, gender, clinical information on site of lesion, form of intubation and surgical procedure performed. Results: Out of 94 patients, 68 with histological diagnosis of ameloblastoma (59 mandibular and 9 maxillary were operated within the study period. The remainder (26 was not treated in hospital. Among 68 patients treated, more were males (38 than females (30, giving a male to female ratio of 1.3:1. The age range was between 14 and 74 years (mean-standard deviation. The duration of the symptoms ranged from 7 months to 24 years, most were follicular ameloblastoma (n = 13 followed by acanthomatous type (n = 7. Endotracheal intubation was the most common (n = 55 followed by fiber optic laryngoscopy (n = 8. The surgical approach most used was extended Risdon with intraoral (n = 24 followed by extended Risdon with lip split and intraoral (n = 17. Segmental resection (en block formed the bulk of our procedures (n = 22 followed by subtotal mandibulectomy (n = 16. Conclusion: The treatment of ameloblastoma remains controversial. Its destructive nature has left patients with wide defects difficult to reconstruct.

  18. Unusual imaging appearance of unicystic ameloblastoma

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    Lakshmi Kavitha Nadendla

    2012-01-01

    Full Text Available Unicystic ameloblastoma (UA refers to those cystic lesions that show clinical, radiographic, or gross features of a mandibular cyst, but on histologic examination show a typical ameloblastous epithelium lining part of the cystic cavity, with or without luminal and/or mural tumor growth. It accounts for 5-15% of all intraosseous ameloblastomas. We report a case of UA in a 35-year-old female with an unusual large multilocular (tennis racket appearance on the right body of mandible and illustrate the importance and complexity of differential diagnosis with a brief review of recent literature.

  19. Maxillary ameloblastoma: An enigma for the surgeon

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    S O Ajike

    2009-01-01

    Full Text Available Background:Ameloblastoma is a benign but locally aggressive odontogenic tumour. Worldwide, maxillary ameloblastoma is rare but its late detection renders adequate treatment difficult. Majority occur in the mandible with about 5-20% occurring in the maxillary bone. Objective: The purpose of this study was to analyze 21 cases of maxillary ameloblastoma seen and managed at the Oral and Maxillofacial Unit of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria and Alba Clinic and Medical Centre, Kaduna, Nigeria. Study Design:A retrospective study of cases of maxillary ameloblastoma from all cases of ameloblastoma seen from January 1993 to August 2008. Data with respect to patient′s sex, age, tumour location, clinical presentation, radiologic features, biological and histopathologic type, surgical treatment and recurrences were analyzed. Results:Out of 350 cases of ameloblastoma seen within the period, 21(6% Patients were with maxillary am eloblastoma. Of the 21 cases, there were 13 males and 8 females, a male female ratio of 1.6 to 1, with an age range of 17-55 years (mean = 38.14, peaking at the 4 th and 5 th decades of life (61.9%. Tumour duration was from 3 months to 14 years. There were 18 unilateral and 3 bilateral swellings. Clinically, maxillary ameloblastoma presented with grotesque swellings, with antral involvement in 19 cases, teeth mobility/exfoliation. Radiologically, there were 20 multilocular and 1 unilocular radiolucent lesions. The most common histopathologic type was follicular (11, 52.4%.there were 22 procedures done on 21 patients; 21 maxillectomies and 1 enucleation. Follow up period of 18 patients was between 3 months and 10 years from which 3(16.7% recurrences were observed. Conclusion:Ameloblastum a is uncommon in the maxilla. While maxillary ameloblastoma is indistinguishable histologically from its mandibular counterpart, it is very lethal. An excellent result achieved in this study was due to the radical mode of

  20. Radiographic analysis of ameloblastoma: A retrospective study

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    Chandramani More

    2012-01-01

    Conclusion: Radiographs are an important aid for the diagnosis of oral lesions of various types, especially those that involve bone. It is important for the practicing clinicians to know the salient features of ameloblastoma which are peculiar to the local population.

  1. Radiographic study of the unicystic ameloblastoma

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    Lee, Ju Duck; An, Chang Hyeon; Choi, Karp Shik [Kyungbook National University College of Medicine, Daegu (Korea, Republic of)

    2005-03-15

    To acquire the useful diagnostic information through the analysis of the clinical and radiological characteristics of mandibular uni cystic ameloblastoma. The researchers compared and analysed the clinical and radiological features of 79 cases of mandibular uni cystic ameloblastoma confirmed by histologic examination. The results of our research showed that uni cystic ameloblastomas occurred more frequently in males than in females and the incidence is the highest in the 2nd and 3rd decades. These lesions occurred most frequently in angle-ramus area, mandibular molar area, and anterior area in descending order respectively 68.4%, 24%, and 7.6%. These lesions had smooth (54.4%) rather than undulating (45.6%) borders. These lesion showed well-defined borders in 59.5% among all the cases. Root resorption and loss of lamina dura were observed as 55.7% and 58.5% respectively. Displacement of mandibular canal was observed in 55.9% among all the related cases. Internal pattern of lesional radiolucency was observed as even (49.4%) or uneven (50.6%). These results would be helpful in diagnosing of mandibular uni cystic ameloblastoma.

  2. Orthodontic treatment combined with autotransplantation after removal of ameloblastoma.

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    Lim, Won Hee; Chun, Youn Sic

    2009-03-01

    This article describes the use of indirect skeletal anchorage and autotransplantation in a patient who had an ameloblastoma removed. The mandibular left second and third molars were also extracted. Autogenous bone was grafted after surgical removal of the ameloblastoma, and the mandibular right third permanent molar was transplanted into the extraction space. Orthodontic treatment included a miniscrew to bring the transplanted tooth into good occlusion. Four years after treatment, the patient continued to show good results, with no recurrence of the ameloblastoma.

  3. Plexiform ameloblastoma mimicking a periapical lesion: A diagnostic dilemma

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    Bina Kashyap

    2012-01-01

    Full Text Available Plexiform ameloblastoma is one of the variant of ameloblastoma, with specific histopathological features. It manifests as unilocular or multilocular radiolucencies in the mandible or maxilla. In very rare cases, it can appear as a localized periradicular radiolucent area and imitate an endodontic lesion. Reported here is a rare case of plexiform ameloblastoma in an uncommon location, which was misdiagnosed as periapical lesion of inflammatory origin and treated endodontically. Surgical enucleation was followed and diagnosis of plexiform ameloblastoma was confirmed on histological grounds.

  4. Peripheral ameloblastoma. Case report and review of the literature

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    Maria LAZARIDOU

    2014-03-01

    Full Text Available Peripheral ameloblastoma is a rare, benign neoplasm of odontogenic origin which develops strictly extraosseously at the gingiva. Histollogically, it resembles intraosseous ameloblastoma. The aim of this study is to report a case of a peripheral ameloblastoma which presented as a painless mass on the left maxillary tuberosity in a 44-year-old male. Its clin-ical features and the details of its surgical treatment are discussed. Discussion: Peripheral ameloblastomas have a better prognosis of their intraosseous counterpart. Aggressive treatment is not recommended since these tumors rarely recur

  5. Perawatan Ameloblastoma Rekuren dengan Metode Dredging

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    R. Rahardjo

    2016-10-01

    Full Text Available Latar belakang. Ameloblastoma dapat menyebabkan kerusakan pada tulang wajah baik pada maksila maupun mandibula. Tumor ini dapat mengalami rekurensi apabila perawatan tidak sempurna. Reseksi pada tulang yang terkena adalah tindakan yang biasa dilakukan untuk perawatan tumor ini. Tindakan ini dapat menyebabkan gangguan maloklusi, gangguan pertumbuhan dan perkembangan gigi dan tulang rahang bila dilakukan pada anak-anak dan remaja, gangguan estetika, dan berdampak psikologis. Oleh karena itu tindakan alternatif dalam perawatan ameloblastoma adalah dengan metode dredging. Tujuan laporan kasus ini menjelaskan perawatan metode dredging pada rekuren ameloblastoma pada penderita laki-laki usia dua puluh tujuh tahun sehingga dapat menghilangkan dampak psikologis dari penderita. Kasus. Penderita laki-laki usia dua puluh tujuah tahun dengan keluhan benjolan dalam mulut, tidak terasa sakit, dan merasa bertambah besar. Terdapat asimetri wajah di sebelah kanan, tidak ada perubahan warna kulit. Penderita mengaku pernah dioperasi tujuh tahun yang lalu. Pada pemeriksaan intra oral didapatkan benjolan pada mandibula di daerah bukal dari daerah gigi 42 sampai 46. Pada palpasi terasa ada fluktuasi, rasa sakit ringan dan warna mukosa normal. Pada gambaran foto panoramic terlihat area radiolusen dengan batas jelas dari daerah 42 sampai 46 dengan melibatkan aspek dari gigi 42 dan 43. Dari hasil biopsi dan pemeriksaan patologi anatomi dinyatakan sebagai ameloblastoma unikistik tipe folikuler. Penatalaksanaan. Dredging dikerjakan dengan melakukan defleksi pada lesi enukleasi dan kuretase. Pada bulan kedua perawatan tindakan tersebut diulangi dan dilakukan pemeriksaan histopatologis. Tindakan tersebut diulang pada bulan kelima dan diulang kembali setiap tiga bulan sampai dinyatakan terbebas dari sel tumor. Kesimpulan. Telah dilakukan dredging pada penderita rekuren ameloblastoma dengan hasil cukup memuaskan dan dilakukan pengamatan yang berlanjut.   Background

  6. Central Ameloblastoma with a Peripheral Ameloblastoma-Like Component: A Case Report

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    Seyyed Hosein Tabatabaei

    2014-09-01

    Full Text Available Amebloblastoma as the most common epithelial odontogenic neoplasm may occur in two forms of central and peripheral. This report presents a case of a 41-year-old Iranian female with a six-month complaint from a painless mass in the right posterior portion of the mandible. The case was diagnosed as an exophytic epulis-like peripheral component with characteristics of peripheral ameloblastoma and an intrabony component like solid ameloblastoma. Two probable hypotheses considered for this case is also discussed.

  7. MANAGEMENT OF LARGE AMELOBLASTOMA: A CASE REPORT

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    Rudagi B M

    2010-03-01

    Full Text Available Ameloblastoma, first recognized by Cusack in 1827, is a neoplasm of odontogenic epithelium, especially of enamel organ-type tissue that has not undergone differentiation to the point of hard tissue formation. It accounts for about 1% of all oral tumors and about 9-11% of odontogenic tumors. Ameloblastoma in the mandible can progress to a great size and cause facial asymmetry, displacement of teeth, malocclusion, and pathologic fractures. A case of large ameloblastoma of mandible in a 39 year old male patient is being reported. Patient had large swelling on left lower side of the jaw since 2 years. Swelling was approximately 15 X 10cm in size. Intraorally the swelling involved buccal and lingual cortical plates and was obliterating the vestibular space. Patient did not seek medical attention because swelling was painless. The patient was investigated and treated with surgical excision and was providedwith prosthesis to correct the post operative sequale. The patient showed uneventful recovery with no recurrence after a follow up of one year.

  8. Desmoplastic ameloblastoma of anterior mandible: Case report of a rarity

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    Prashant Nahar

    2008-01-01

    Full Text Available Ameloblastoma, one of the most common odontogenic tumors of the jaws, presents classical clinical, radiographic and histopathological diagnostic features exhibiting a benign but locally aggressive and destructive clinical course with a high rate of recurrence. A case of desmoplastic ameloblastoma of mandible is discussed in this article, which presents itself as a rare variant of ameloblastoma with unusual inconclusive clinico-radiographic features to be diagnosed as classical ameloblastoma and difficult to differentiate from other suspected multilocular benign odontogenic or reactive lesions of the jaws. It is the typical histopathological picture of the lesion exhibiting a blend of desmoplasia (collagenization and ameloblastoma that leads to its final diagnosis and determines its management.

  9. Giant neglected ameloblastoma: single stage treatment and clinicopathological review.

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    Kalavrezos, Nicholas; Baldwin, David James; Walker, D Murray

    2008-10-01

    Giant ameloblastomas may present with massive swelling of the jaws. We report a giant ameloblastoma of the mandible in a Nigerian patient that measured 15.1x12.2x13.6cm and was managed with a single procedure. The tumour was removed by segmental mandibulectomy and reconstructed with a fibular free flap. The excess soft tissue was treated with a bilateral commissuroplasty. Single stage treatment that establishes early functional and aesthetic recovery offers advantages over multi staged procedures, and is therefore the treatment of choice for giant ameloblastomas.

  10. Identification of recurrent SMO and BRAF mutations in ameloblastomas.

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    Sweeney, Robert T; McClary, Andrew C; Myers, Benjamin R; Biscocho, Jewison; Neahring, Lila; Kwei, Kevin A; Qu, Kunbin; Gong, Xue; Ng, Tony; Jones, Carol D; Varma, Sushama; Odegaard, Justin I; Sugiyama, Toshihiro; Koyota, Souichi; Rubin, Brian P; Troxell, Megan L; Pelham, Robert J; Zehnder, James L; Beachy, Philip A; Pollack, Jonathan R; West, Robert B

    2014-07-01

    Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. Mutations in SMO (encoding Smoothened, SMO) are common in ameloblastomas of the maxilla, whereas BRAF mutations are predominant in tumors of the mandible. We show that a frequently occurring SMO alteration encoding p.Leu412Phe is an activating mutation and that its effect on Hedgehog-pathway activity can be inhibited by arsenic trioxide (ATO), an anti-leukemia drug approved by the US Food and Drug Administration (FDA) that is currently in clinical trials for its Hedgehog-inhibitory activity. In a similar manner, ameloblastoma cells harboring an activating BRAF mutation encoding p.Val600Glu are sensitive to the BRAF inhibitor vemurafenib. Our findings establish a new paradigm for the diagnostic classification and treatment of ameloblastomas.

  11. Recurrent unicystic ameloblastoma in a child

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    Irulandy Ponniah

    2011-01-01

    Full Text Available Unicystic ameloblastoma (UCA is a clinical subtype of ameloblastoma that is considered prognostically different. The purpose of this report is to present a case of UCA showing dual radiographic pattern in a child. A detailed study of the lesion was carried out in an 8 year old female child who presented to our department of oral and maxillofacial pathology. Clinical, radiological and histopathological findings were recorded. In March 2005, a painless swelling in the left side of the mandible was noted, which on radiographic examination showed a unilocular radioluceny enclosing the crown of mandibular left permanent second molar, extending between the left first permanent molar and anterior margin of the ramus. Histopathologic diagnosis was UCA. The lesion was treated by enucleation. The patient returned with recurrence in 2009, at this time the lesion radiographically presented as a multilocular radiolucency with a soap bubble appearance, extending between the anterior border of the ramus and second premolar. Histopathologic diagnosis was UCA. The lesion was treated by segmental resection with immediate reconstruction. Although a number of treatment modalities are available to treat UCA, many factors need to be taken into consideration in the treatment of UCA in children.

  12. Identification of recurrent SMO and BRAF mutations in ameloblastomas

    OpenAIRE

    2014-01-01

    Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. Mutations in SMO (encoding Smoothened, SMO) are common in ameloblastomas of the maxilla, whereas BRAF mutations are predominant in tumors of the mandible. We show that a frequently occurring SMO alteration encoding p.Leu412Phe is an activating mutation...

  13. Ameloblastoma: a clinical review and trends in management.

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    McClary, Andrew C; West, Robert B; McClary, Ashley C; Pollack, Jonathan R; Fischbein, Nancy J; Holsinger, Christopher F; Sunwoo, John; Colevas, A Dimitrios; Sirjani, Davud

    2016-07-01

    Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

  14. PERIPHERAL AMELOBLASTOMA - A CASE-REPORT AND REVIEW OF THE LITERATURE

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    NAUTA, JM; PANDERS, AK; SCHOOTS, CJF; VERMEY, A; ROODENBURG, JLN

    1992-01-01

    Peripheral ameloblastoma is a benign odontogenic tumor with the same histological characteristics as the centrally located ameloblastoma, but appearing in the gingiva and mucosa of the tooth-bearing area of the jaws. A review is presented of 53 cases: 45 being reported as peripheral ameloblastoma an

  15. Hybrid Ameloblastoma of the Maxilla: A Puzzling Pathology

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    Chintamaneni Raja Lakshmi

    2016-07-01

    Full Text Available Ameloblastomas are slow growing, locally invasive, benign odontogenic tumors of an epithelial origin, accounting for approximately 1% of all oral tumors. A 40-year-old man presented with a chief complaint of a swelling over the left side of his face of 4 years’ duration. On examination, gross facial asymmetry was detected, and a well-defined swelling was noted intraorally involving the left maxilla medially from the mid palatal raphe and obliterating the buccal vestibule laterally. The swelling was non-tender and exhibited dual consistencies: firm in the palate and cystic in the vestibular region. Computed tomography revealed a multilocular radiolucency, which involved the left maxilla, encroached into the left maxillary sinus and the nasal complex, and caused bony erosion. Early diagnosis and treatment are the key tools in managing ameloblastomas, failure of which may lead to a significant deterioration of the prognosis and an increased recurrence rate. Uncommon variants of ameloblastomas have been gaining interest recently. To date, 25 cases of hybrid ameloblastomas have been documented in the scientific literature. We present an extremely rare hybrid type of the ameloblastoma with combined follicular, cystic, acanthomatous, and desmoplastic variants, which render it the first of its kind to have ever been reported.

  16. Unicystic ameloblastoma with diverse mural proliferation - a hybrid lesion.

    Science.gov (United States)

    Mahadesh, Jyothi; Rayapati, Dilip Kumar; Maligi, Prathima M; Ramachandra, Prashanth

    2011-03-01

    A 46-year-old man was referred to our hospital for treatment, complaining of swelling on the right mandibular molar region. Radiographic examination revealed a well defined multilocular radiolucent lesion with root resorption of right lower anteriors and molars. Following biopsy, a diagnosis of unicystic ameloblastoma of mural type was made and hemimandibulectomy was performed under general anesthesia. Histopathological examination of the surgical specimen exhibited a unicystic ameloblastoma of luminal, intraluminal, and mural type. Intraluminal proliferation was of plexiform pattern and mural proliferation showed unusual histopathological findings, which revealed follicular, acanthomatous areas coexisted with desmoplastic areas. This mural picture was similar to the so-called 'hybrid lesion of ameloblastoma', whose biological profile is not elicited due to the lack of adequate published reports. Two years follow up till date has not revealed any signs of recurrence.

  17. Unicystic ameloblastoma with diverse mural proliferation - a hybrid lesion

    Energy Technology Data Exchange (ETDEWEB)

    Mahadesh, Jyothi [Sri Siddhartha Dental College and Hospital, (India); Rayapati, Dilip Kumar; Maligi, Prathima M; Ramachandra, Prashanth [Dayananda Sagar College of Dental Sciences, Bengaluru (India)

    2011-03-15

    A 46-year-old man was referred to our hospital for treatment, complaining of swelling on the right mandibular molar region. Radiographic examination revealed a well defined multilocular radiolucent lesion with root resorption of right lower anteriors and molars. Following biopsy, a diagnosis of unicystic ameloblastoma of mural type was made and hemimandibulectomy was performed under general anesthesia. Histopathological examination of the surgical specimen exhibited a unicystic ameloblastoma of luminal, intraluminal, and mural type. Intraluminal proliferation was of plexiform pattern and mural proliferation showed unusual histopathological findings, which revealed follicular, acanthomatous areas coexisted with desmoplastic areas. This mural picture was similar to the so-called 'hybrid lesion of ameloblastoma', whose biological profile is not elicited due to the lack of adequate published reports. Two years follow up till date has not revealed any signs of recurrence.

  18. Desmoplastic variant of ameloblastoma of the maxilla: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Kwang Joon; Park, Ha Na; Kim, Kyoung A [Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju (Korea, Republic of)

    2015-12-15

    The desmoplastic variant of ameloblastoma is a rare form of ameloblastoma characterized by unique radiographic and histologic features. A 46-year-old female was referred to our hospital, complaining of swelling in the left upper lip area. Radiographic findings revealed an ill-defined multilocular lesion with a large cystic lesion and thick sclerotic trabeculae on the left anterior maxilla. After the patient underwent partial osteotomy, histologic analysis revealed a desmoplastic ameloblastoma with no evidence of a hybrid lesion or cyst formation. The radiographic findings in the present case were different from those described in previous case reports. These findings are of special importance due to the unfamiliar radiographic and histologic features of this lesion.

  19. Nuclear morphometry in canine acanthomatous ameloblastomas and squamous cell carcinomas

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    M Martano

    2009-06-01

    Full Text Available The aim of this study was to evaluate whether morphometrical analysis can be of diagnostic value for canine acanthomatous ameloblastoma. We calculated, by means of an automated image analyser, some morphometric nuclear parameters, in particular: mean nuclear area (MNA, mean nuclear perimeter (MNP, maximum and minimum diameters (MDx and MDm coefficient of variation of the nuclear area (NACV, largest to smallest dimension ratio (LS ratio, and form factor (FF, in 8 canine acanthomatous ameloblastomas, and we compared these morphometric data to those of 13 squamous cell carcinomas of canine gingiva. The results indicated a progressive increase of the MNA, NACV, MNP and MDm proceeding from acanthomatous ameloblastomas (MNA: 42.11±8.74; NACV: 28,36±7,23; MNP: 24.18± 2.68; MDm: 5.69±0.49 to squamous cell carcinomas (MNA:49,69±9,10; NACV: 30,89±7,75; MNP: 25.63±2.54; MDm: 6.64±0.73. On the contrary, the LS ratio and the FF resulted greater in acanthomatous ameloblastomas (LS ratio: 1,63±0,12; FF: 1,13±0,002 than in SCCs (LS ratio: 1,40±0,12; FF:0.91±0.38. Moreover, the MNA, MNP,MDx and MDm resulted similar (MNA: p=0.89; MNP: p=0,65; MDm: p=0,16; MDx: p=0,13 in a subset of four acanthomatous ameloblastomas with cellular atypia (MNA:49,01±6,88; MNP: 26,28±1,99; MDm: 6.08±0.41; MDx: 10.18±0.88 and in squamous cell carcinomas (MNA:49.69±9,10; MNP: 25.63±2.54; MDm: 6.64±0.73; MDx: 9.26±1.05. While the NACV values resulted higher in typical acanthomatous ameloblastoma (29,99±6,06 than in atypical acanthomatous ameloblastoma (26,74±8,84 and similar to those of the SCCs (30,89±7,75. These results seem to confirm that acanthomatous ameloblastoma is a malignant or potentially malignant lesion and emphasizes that nuclear morphometry analysis can be an useful diagnostic and prognostic method in canine oral pathology.

  20. [Desmoplastic ameloblastoma in a 7 year old child].

    Science.gov (United States)

    Mikou, A; Al Bouzidi, A; Kabbaj, R; Chahdi, H; Kamous, W; Zoubeir, Y; Rharrassi, I; Rimani, M; Labraimi, A; El Khatib, M; Rzin, A; Nassih, M

    2008-01-01

    Desmoplastic ameloblastoma is a benign, locally aggressive neoplasm of proliferating odontogenic epithelial origin. It is seen among old patients from 17 to 72 years with an average age 42 years and without predilection of sex. We report the case of a 7 year old child, having presented since the 5 years age, a gingival tumefaction on the left higher incisivo-canin group which increased volume gradually. The stomatologic examination showed a gingival tumefaction covered with a healthy mucous membrane, ovoid form and measuring 3 cm on its horizontal axis. The tomodensitometry of the jawbone showed in front of the 21st and the 22nd tooth, the presence of an osseous lesion associating of the hearths of osteolysis and osteocondensation with rupture of cortical and invasion of the soft tissue. A curetting of the lesion was carried out and the anatomopathologic examination retained the diagnosis of desmoplastic ameloblastoma. The characteristic of our observation is the youth of the patient. In addition, the desmoplastic ameloblastoma is relatively rare, is characterized by an anatomical distribution, a radiological appearance and a morphological aspect differents from the traditional ameloblastoma. A radical surgical treatment is suggested for this tumour to avoid recurrency.

  1. Granular cell ameloblastoma : A case report with a brief note on review of literature

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    Shelly Arora

    2014-11-01

    Full Text Available Ameloblastomas are tumours of odontogenic epithelial origin with varied microscopic patterns that occur either singly or in combination. Granular cell pattern is rarely seen in ameloblastoma, and is characterised by nests of large eosinophilic granular cells. This article describes a case of granular cell ameloblastoma in a 29 year old male patient with clinical, radiology and histological findings along with a short on review of literature.

  2. Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma

    OpenAIRE

    KANDA, SHIORI; MITSUYASU, TAKESHI; NAKAO, YU; Kawano, Shintaro; GOTO, YUICHI; Matsubara, Ryota; Nakamura, Seiji

    2013-01-01

    Sonic hedgehog (SHH) signaling pathway is crucial to growth and patterning during organogenesis. Aberrant activation of the SHH signaling pathway can result in tumor formation. We examined the expression of SHH signaling molecules and investigated the involvement of the SHH pathway in the proliferation of ameloblastoma, the most common benign tumor of the jaws. We used immunohistochemistry on ameloblastoma specimens and immunocytochemistry and reverse transcription-PCR on the ameloblastoma ce...

  3. Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update

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    Ravleen Nagi

    2016-01-01

    Full Text Available Ameloblastoma is the second most common benign epithelial odontogenic tumor and though it is of a benign nature, it is locally invasive, has a high recurrence rate and could potentially become malignant. Many theories have been proposed to explain the pathogenesis of ameloblastoma. Proper understanding of the pathogenic mechanism involved in ameloblastoma and its proliferation aids in constituting proper treatment of choice at an early stage, preventing morbidity associated with extensive therapy. An attempt has been made to discuss the current concepts related to molecular and genetic changes that occur in ameloblastoma as these could affect treatment plan and prognosis.

  4. Caracterização imuno-histoquímica de lesão híbrida de ameloblastoma desmoplásico e convencional "Hybrid" lesion of desmoplastic and conventional ameloblastoma: immunohistochemical aspects

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    Jean Nunes dos Santos

    2006-10-01

    Full Text Available O ameloblastoma é uma neoplasia odontogênica benigna comumente encontrada nos ossos maxilares. Histologicamente, mostra diversos padrões, incluindo a ameloblastoma plexiforme e folicular. Quando estes padrões histológicos coexistem com um ameloblastoma que exibe abundante desmoplasia, são então denominados de lesão ‘híbrida" de ameloblastoma desmoplásico e convencional. No presente trabalho, nos propomos a relatar um caso de lesão híbrida de ameloblastoma desmoplásico e convencional destacando os aspectos imuno-histoquímicos relativos a expressão das proteínas da matriz extracelular (tenascina, fibronectina e colágeno I.Ameloblastoma is a benign epithelial odontogenic tumor and is the most commonly encountered odontogenic tumor in the jaws. Histologically, ameloblastomas occur in different patterns, including plexiform pattern and follicular pattern. "Hybrid " lesion of ameloblastoma is a tumor variant in which histologically, areas of follicular or plexiform ameloblastoma coexist with characteristic areas of ameloblastoma exhibiting pronounced stromal desmoplasia (desmoplastic ameloblastoma. The purpose of this article is to present a case of "hybrid" lesion of desmoplastic ameloblastoma (AD and conventional, and investigate extracellular matrix proteins such as tenascin, fibronectin, and type I collagen.

  5. Ameloblastoma: a clinical and therapeutic analysis on six cases.

    Science.gov (United States)

    de Moraes, Frederico Barra; Cardoso, Rhanderson Miller Nascimento; Rodrigues, Sinara Vieira; Dutra, Marcus Vinícius Ferreira; Pereira, Uiara Rios; Borges, Thiago Raphael Sousa Alencar

    2014-01-01

    Ameloblastomas are odontogenic tumors that are locally invasive and slow-growing. Their etiology is still not well defined, but the forms of treatment have been widely discussed because of the possibility of tumor recurrence and postoperative complications. In this study, six patients who were diagnosed with ameloblastoma in the mandibular region and were treated in the Department of Orthopedics and Traumatology of Hospital das Clínicas, Federal University of Goiás, between 1958 and 1963, were evaluated. The radiological, clinical and therapeutic characteristics were evaluated. There was no predominance regarding gender in the sample studied. The symptoms most often presented by the patients were pain and tumor formation. The radiological characteristics with greatest incidence were multilocular lesions and the treatment used for all the patients was radical surgery. There was no recurrence over the minimum follow-up period of one year and six months.

  6. Epidemiology of ameloblastomas of the jaws; a report from the Netherlands

    NARCIS (Netherlands)

    M.A.E.M. Oomens; I. van der Waal

    2014-01-01

    Objectives: To provide epidemiological data of ameloblastomas of the jaws in the Netherlands over a 25-year time period (1985-2010) and to compare these data with data from other parts of the world. Material and Methods: The data of all patients diagnosed with a primary ameloblastoma of the jaws in

  7. Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population

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    Ndukwe Kizito C

    2006-11-01

    Full Text Available Abstract Background This study was carried out to establish the relative incidence and provide clinico-pathologic information on the various histological types of ameloblastoma seen at the Obafemi Awolowo University Teaching Hospital complex, Ile-Ife in order to provide a baseline data which will be of significance to the pathologist and clinician. Methods Clinico-pathologic data on a total of 77 histologically diagnosed cases of ameloblastoma archieved at the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife over a 15 year period were obtained and analysed descriptively. Results Follicular ameloblastoma was the most common histological type (50 cases, 64.9%, followed by plexiform ameloblastoma (10 cases, 13.0%. 4 (5.2% cases of desmoplastic and 3 (3.9% cases of acanthomatous ameloblastoma were seen while the basal cell variant accounted for 2 (2.6% cases. Only 1 case of the unicystic type was seen. Some of the 77 cases presented as a mixture of two or more histological types. Ameloblastoma occurred over an age range of 11 to 70 years with a peak age incidence in the 3rd decade. Conclusion This study provides a baseline data on variants of ameloblastoma as obtained in a suburban Nigerian population. Since variants of ameloblastoma differ in biologic behaviour, the data collected in this study provides clinicopathologic information which is of significance to the pathologist and clinician.

  8. Maxillary unicystic ameloblastoma: A review of the literature

    Science.gov (United States)

    Singh, Anil; Shaikh, Shoyeb; Samadi, Fahad M.; Shrivastava, Shikha; Verma, Ruchita

    2011-01-01

    The term unicystic ameloblastoma (UA) refers to those cystic lesions that show clinical, radiographic, or gross features of a jaw cyst, but on histologic examination show a typical ameloblastomatous epithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth. Although the histology suggests that cystic ameloblastomas follow a biologically low-grade course, recent evidence suggests that they may often behave clinically as aggressive tumors. This is supported by the high incidence of cortical perforation, tooth resorption, increase in lesion size, bony destruction, and a high rate of recurrence after simple enucleation. Here, the authors present a case report on unicystic variant of ameloblastoma in the maxilla. An attempt has been made to emphasize that it can involve the maxillary jaw, which is rarely affected and could be more aggressive than previously thought. A literature review on the topic has been added along with the case report. It is important to remember that a proper and timely diagnosis of the character and extent of a UA (with a thorough histopathologic examination of the entire specimen) can help in the overall long-term well-being of the patient. PMID:22639505

  9. Ameloblastoma de fossa nasal: revisão bibliográfica e relato de dois casos Nasal ameloblastoma: literature review and report of two cases

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    Washington L. C. Almeida

    2001-09-01

    Full Text Available O ameloblastoma é um tumor bastante incomum na cavidade nasal. Surge a partir do epitélio odontogênico, podendo estender-se ao seio maxilar, órbitas e base de crânio. Apresentamos dois casos de ameloblastoma em fossa nasal direita, associados a sintomas nasossinusais e seus principais achados, clínicos e cirúrgicos.Ameloblastoma is a very unusual tumor in the nasal cavity. It arises from the odontogenic epithelium and extends up to the maxillary sinus, orbits and skull base. We have presented two cases of ameloblastoma, both in the right nasal cavity, associated with nasal and sinusal symptoms, and reported the main surgical and clinical findings.

  10. P63 and Ki-67 Expression in Dentigerous Cyst and Ameloblastomas

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    Zohreh Jaafari-Ashkavandi

    2015-12-01

    Full Text Available Statement of the Problem: P63 gene is a member of TP53 and its homologous gene family. Its expression was observed in some odontogenic lesions, more expression in aggressive lesions. Purpose: This study aimed to investigate the possible diagnostic impact of P63 protein on dentigerous cysts and various types of ameloblastoma. Its expression with Ki-67 proliferation marker was also compared. Materials and Method: This cross-sectional retrospective study was enrolled on 25 cases of dentigerous cyst including 21 unicystic ameloblastomas and 17 conventional ameloblastomas. The expression of P63 and Ki-67 was assessed by immunohistochemical (IHC examinations. Data were analyzed by employing Mann-Whitney and correlation coefficient tests. Results: P63 expression was significantly higher in ameloblastoma than unicystic ameloblastoma and dentigerous cysts. There was no significant difference between unicystic ameloblastoma and dentigerous cyst in P63 expression. A 90% cut-off point was obtained for basal layer which gave 88% sensitivity and 78% specificity to distinguish more invasive lesions from others. There was not any correlation between P63 and Ki-67 immunostaining in the three study groups. Conclusion: More aggressiveness and more invasiveness of odontogenic lesions depicted higher rate and also more intensive expression of P63. Moreover, the expression of P63 protein had not any correlation with Ki-67 protein in dentigerous cysts and ameloblastomas.

  11. Recurrent unicystic mural type ameloblastoma in a 9-year-old boy, 8 years follow-up

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    Burcu Sengüven

    2013-01-01

    Full Text Available Unicystic ameloblastoma is not a rare odontogenic tumor in the pediatric population. A significant care should be given to unicystic ameloblastoma if it has mural invasions due to its local aggressiveness, high recurrence rates and radical management options as in conventional ameloblastoma. Fine needle aspiration (FNA cytology is a rapid, non-traumatic diagnostic method that provides a required attention prior to surgery. We present an excisionsl biopsy proved FNA diagnosed mural type unicystic ameloblastoma in a 9-year-old child recurred as a solid ameloblastoma after 8 years. When distinctive features of ameloblastoma are known, an accurate diagnosis can be made by FNA cytology, in combination with clinicoradiological findings. This method gives benefit to the patients especially the younger ones both for the pre-operative surgical planning and the post-operative follow-up.

  12. Ameloblastoma of the Sinonasal Tract: Report of a Case with Clinicopathologic Considerations

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    Maria Grazia Tranchina

    2012-01-01

    Full Text Available Ameloblastomas are locally aggressive jaw tumours with a high propensity for recurrence and are believed to arise from remnants of dental lamina or odontogenic epithelium. Extragnathic ameloblastomas are unusual, and primary sinonasal tract origin is very uncommon with few cases reported in the literature. We herein report a case of primary sinonasal ameloblastoma presented in a 74-year-old male with nasal obstruction, rhinorrhoea, and sinusitis. Nasal endoscopy showed the right nasal cavity completely obstructed by a polypoid lesion attached to the lateral nasal wall. A preoperative CT scan was performed showing a solid lesion, measuring 2 cm in the maximum diameter, extending from the nasopharynx area with obstruction of the ostiomeatal unit and sphenoethmoidal recess into the lateral pharyngeal space, laterally to the parotid, without continuity with maxillary alveola and antrum. The tumour was completely excised endoscopically, and a final diagnosis of ameloblastoma was rendered. At the 12-month followup, there was no evidence of recurrence.

  13. Is Conservative Surgical Treatment Sufficient to Treat Unicystic Mural Ameloblastoma in Infant?

    Science.gov (United States)

    Acar, Ahmet Hüseyin; Yolcu, Ümit; Erdem, Necip Fazil; Asutay, Fatih

    2015-06-01

    Ameloblastoma, a benign neoplasm derived from odontogenic epithelium, is an aggressive and locally invasive tumor. It represents 11% of all odontogenic tumors and 1% of all oral odontogenic epithelial tumors. In this case report, a 20-month-old boy was referred to our clinic with complaint of collapse in his symphysis region of the mandible. Radiographic examination revealed unilocular radiolucency in this region. The lesion was enucleated with 1 tooth germ under general anesthesia and diagnosed as mural unicystic ameloblastoma by histopathologic examination. After the surgery, complete healing was obtained clinically and radiographically. No sign of recurrence has been seen during the follow-up period of 4.5 years. To our knowledge, this was the second youngest case of ameloblastoma in the English literature. However, it is the youngest case of ameloblastoma that occurred in an infant boy.

  14. The regulation of bone turnover in ameloblastoma using an organotypic in vitro co-culture model

    Science.gov (United States)

    Eriksson, Tuula M; Day, Richard M; Fedele, Stefano; Salih, Vehid M

    2016-01-01

    Ameloblastoma is a rare, odontogenic neoplasm with benign histopathology, but extensive, local infiltrative capacity through the bone tissue it originates in. While the mechanisms of ameloblastoma invasion through the bone and bone absorption are largely unknown, recent investigations have indicated a role of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand regulatory mechanisms. Here, we present results obtained using a novel in vitro organotypic tumour model, which we have developed using tissue engineering techniques. Using this model, we analysed the expression of genes involved in bone turnover and detected a 700-fold increase in receptor activator of nuclear factor kappa-B ligand levels in the co-culture models with ameloblastoma cells cultured with bone cells. The model described here can be used for gene expression studies, as a basis for drug testing or for a more tailored platform for testing of the behaviour of different ameloblastoma tumours in vitro.

  15. A repeatedly recurrent desmoplastic ameloblastoma after removal and allobone graft: Radiographic features compared with histological changes

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Duk; Jang, Hyun Seon; Seo, Yo Seob; Kim, Jin Soo [School of Dentistry, Chosun University, Gwangju (Korea, Republic of)

    2013-09-15

    A 40-year-old man suffered from a repeatedly recurrent desmoplastic ameloblastoma in the right maxillary anterior and premolar regions. During the first visit, the patient was provisionally histopathologically diagnosed with a developmental cyst, and it was confirmed to be unicystic ameloblastoma and resected. Four years later, the lesion recurred, and was diagnosed as a desmoplastic type of ameloblastoma and removed again. Then, 5 years after the second surgery, the lesion recurred again, and was diagnosed as a type containing a follicular pattern, recurrent ameloblastoma. A panoramic radiograph showed a multilocular and mixed radiolucent/radiopaque expansile lesion at the first visit, a unilocular cystic lesion confined to the premolar area at the second visit, and a small soap bubble appearance in the molar area in the final visit. Cone-beam computed tomographic images of the final recurrence of the tumor revealed multiple small cyst-like structures in the right maxillary anterior and posterior regions.

  16. Distribution of basement membrane type IV collagen alpha chains in ameloblastoma: an immunofluorescence study

    OpenAIRE

    Nakano, K.; Siar, C. H.; Nagai, N.; Naito, I.; Sado, Y.; Nagatsuka, H; Hoh, C; Kurada, K.; Tsujigiwa, H; M. Gunduz

    2002-01-01

    Background: Type IV collagen, a heterotrimeric molecule that exists in six genetically distinct forms, alpha1(IV)-alpha6(IV) is a major structural component of basement membrane (BM) and acts as a scaffold for other BM constituents. Methods: Indirect immunofluorescence using alpha chain-specific monoclonal antibodies was employed to clarify basement membrane (BM) collagen IV distribution in two ameloblastoma, and for comparison, on oral mucosa and tooth germ. Results: Ameloblastoma BM express...

  17. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Fuchigami, Takao [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Kibe, Toshiro [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Koyama, Hirofumi; Kishida, Shosei; Iijima, Mikio [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Nishizawa, Yoshiaki [Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Hijioka, Hiroshi; Fujii, Tomomi [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Ueda, Masahiro [Natural Science Centre for Research and Education, Kagoshima University, 1-21-24 Koorimoto, Kagoshima 890-8580 (Japan); Nakamura, Norifumi [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Kiyono, Tohru [Department of Virology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuouku, Tokyo 104-0045 (Japan); Kishida, Michiko, E-mail: kmichiko@m2.kufm.kagoshima-u.ac.jp [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan)

    2014-09-05

    Highlights: • We studied the interaction between tumor cells and fibroblasts in ameloblastoma. • AM-3 ameloblastoma cells secreted significantly high IL-1α levels. • IL-1α derived from AM-3 cells promoted IL-6 and IL-8 secretion of fibroblasts. • IL-6 and IL-8 activated the cellular motility and proliferation of AM-3 cells. - Abstract: Ameloblastoma is an odontogenic benign tumor that occurs in the jawbone, which invades bone and reoccurs locally. This tumor is treated by wide surgical excision and causes various problems, including changes in facial countenance and mastication disorders. Ameloblastomas have abundant tumor stroma, including fibroblasts and immune cells. Although cell-to-cell interactions are considered to be involved in the pathogenesis of many diseases, intercellular communications in ameloblastoma have not been fully investigated. In this study, we examined interactions between tumor cells and stromal fibroblasts via soluble factors in ameloblastoma. We used a human ameloblastoma cell line (AM-3 ameloblastoma cells), human fibroblasts (HFF-2 fibroblasts), and primary-cultured fibroblasts from human ameloblastoma tissues, and analyzed the effect of ameloblastoma-associated cell-to-cell communications on gene expression, cytokine secretion, cellular motility and proliferation. AM-3 ameloblastoma cells secreted higher levels of interleukin (IL)-1α than HFF-2 fibroblasts. Treatment with conditioned medium from AM-3 ameloblastoma cells upregulated gene expression and secretion of IL-6 and IL-8 of HFF-2 fibroblasts and primary-cultured fibroblast cells from ameloblastoma tissues. The AM3-stimulated production of IL-6 and IL-8 in fibroblasts was neutralized by pretreatment of AM-3 cells with anti-IL-1α antibody and IL-1 receptor antagonist. Reciprocally, cellular motility of AM-3 ameloblastoma cells was stimulated by HFF-2 fibroblasts in IL-6 and IL-8 dependent manner. In conclusion, ameloblastoma cells and stromal fibroblasts behave

  18. Ameloblastoma uniquístico, bases del tratamiento conservador: Presentación de caso clínico y actualización de la bibliografía Conservative treatment of unicystic ameloblastoma: Case report and literature review

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    Juan Argandoña Pozo

    2011-06-01

    Full Text Available El ameloblastoma se define como un tumor localmente agresivo e infiltrante, con alta capacidad de recidiva. Este comportamiento agresivo e infiltrante plantea el problema de una opción conservadora o radical de tratamiento, con las alteraciones funcionales, estéticas y psicológicas que ello implica. El ameloblastoma uniquístico se describe como una lesión con cuadros morfológicos particulares, comportamiento biológico menos agresivo que el ameloblastoma común, así como también una recurrencia menor frente al tratamiento conservador. Se presenta un caso clínico con el diagnóstico de ameloblastoma uniquístico tratado de forma conservadora mediante descompresión y posterior enucleación. Se actualiza la información sobre su tratamiento.Ameloblastoma is defined as a locally aggressive, infiltrating tumor with high recurrence capacity. This aggressive and infiltrating behavior conditions the choice of conservative or radical therapy and the functional, cosmetic and psychological consequences of this choice. Unicystic ameloblastoma is described as a lesion with specific morphological pictures, less aggressive biological behavior than common ameloblastoma and less recurrence with conservative therapy. A case of unicystic ameloblastoma treated conservatively by decompression and enucleation is reported. The therapeutic options are reviewed.

  19. Demographic and histopathological variation of ameloblastoma: A hospital-based study

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    Santanu Patsa

    2016-01-01

    Full Text Available Context: Ameloblastoma is the second most common odontogenic tumor after odontoma which occurs exclusively in the jaws and very rarely in the sinonasal cavities. Aims: The aim of the study was to determine the demographic and histopathological variations of ameloblastoma in Eastern Indian population by retrospectively comparing and evaluating diagnosed cases of ameloblastoma using different parameters. Materials and Methods: Histopathologically diagnosed cases of ameloblastoma retrieved from past records of the Department of Oral Pathology were selected for the study. Totally, 148 cases were isolated from record of previous 7 years. The patients were divided according to (a gender, (b age group, (c site of the lesion and (d histopathological types. The findings of this study were compared with those available in literature. Statistical Analysis Used: This is a retrospective study, mean and standard deviation was calculated. Results: Among 148 patients, 88 (59.45% were male and 60 (40.55% were female. A maximum number of cases (101 of 148 of ameloblastoma were found in the second to fourth decades of life. Mandiblular posterior region was commonly involved (48.6%. Solid/multicystic variety was found in 63.1% followed by unicystic with 21.5%. We found one case each of extraosseous and desmoplastic ameloblastoma. It was difficult for panel of experienced oral pathologists to pinpoint the exact type in 15 (10% cases, this was due to mixture of follicular and plexiform variety with equal presence of both types of architecture, without predominance of any variety in particular. Conclusions: These data may serve as baseline information on occurrence of various histopathological types of ameloblastoma in Eastern Indian population and helps comparing it with other similar studies conducted in different geographic population.

  20. Demographic and histopathological variation of ameloblastoma: A hospital-based study

    Science.gov (United States)

    Patsa, Santanu; Jadav, Riteshkumar Baldevbhai; Halder, Gopal Chandra; Ray, Jay Gopal; Datta, Sila; Deb, Tushar

    2016-01-01

    Context: Ameloblastoma is the second most common odontogenic tumor after odontoma which occurs exclusively in the jaws and very rarely in the sinonasal cavities. Aims: The aim of the study was to determine the demographic and histopathological variations of ameloblastoma in Eastern Indian population by retrospectively comparing and evaluating diagnosed cases of ameloblastoma using different parameters. Materials and Methods: Histopathologically diagnosed cases of ameloblastoma retrieved from past records of the Department of Oral Pathology were selected for the study. Totally, 148 cases were isolated from record of previous 7 years. The patients were divided according to (a) gender, (b) age group, (c) site of the lesion and (d) histopathological types. The findings of this study were compared with those available in literature. Statistical Analysis Used: This is a retrospective study, mean and standard deviation was calculated. Results: Among 148 patients, 88 (59.45%) were male and 60 (40.55%) were female. A maximum number of cases (101 of 148) of ameloblastoma were found in the second to fourth decades of life. Mandiblular posterior region was commonly involved (48.6%). Solid/multicystic variety was found in 63.1% followed by unicystic with 21.5%. We found one case each of extraosseous and desmoplastic ameloblastoma. It was difficult for panel of experienced oral pathologists to pinpoint the exact type in 15 (10%) cases, this was due to mixture of follicular and plexiform variety with equal presence of both types of architecture, without predominance of any variety in particular. Conclusions: These data may serve as baseline information on occurrence of various histopathological types of ameloblastoma in Eastern Indian population and helps comparing it with other similar studies conducted in different geographic population. PMID:27601814

  1. Immunohistochemical expression of calretinin in ameloblastoma, adenomatoid odontogenic tumor, and keratocystic odontogenic tumor: a comparative study.

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    Koneru, Anila; Hallikeri, Kaveri; Nellithady, Ganesh Shreekanth; Krishnapillai, Rekha; Prabhu, Sudeendra

    2014-01-01

    Calretinin is expressed primarily in the central and peripheral nervous system and extensively studied in colon adenocarcinoma and mesotheliomas. Calretinin is known to be expressed in the odontogenic epithelium and odontogenic tumors. However, the role of calretinin in the pathogenesis of odontogenic tumors is yet to be confirmed. Hence, the aim of the present study was to evaluate the expression and role of calretinin in selected odontogenic tumors. The study included 30 ameloblastomas, 30 adenomatoid odontogenic tumors, and 30 keratocystic odontogenic tumors. Staining intensity, pattern, and localization of the immunopositive cells were determined. Statistical analysis was performed using Mann-Whitney U test and Kruskal-Wallis analysis of variance test. P-values <0.05 were considered to be statistically significant. Results showed that 90% ameloblastomas and 80% keratocystic odontogenic tumors were immunopositive to calretinin, whereas none of the adenomatoid odontogenic tumors showed reactivity. Intensity was higher in the ameloblastomas compared with the keratocystic odontogenic tumors. Statistically significant differences were observed when the expression of calretinin was compared, except between the ameloblastoma and keratocystic odontogenic tumor. However, the intensity of calretinin was significantly higher in the ameloblastoma when compared with the keratocystic odontogenic tumor. On the basis of these results, it is suggested that calretinin might be used as a specific immunohistochemical marker for the ameloblastomas and could play an important role in the differentiation of aggressiveness of different odontogenic tumors. Depending on the cell regulatory processes, we suggest a possible role of calretinin in the pathogenesis of ameloblastomas and have to be further studied along with other proliferative cell cycle and apoptotic markers with larger sample size.

  2. Desmoplastic ameloblastoma mimicking a periapical lesion = Ameloblastoma desmoplásico mimetizando lesão periapical

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    Santos, Esaú Pinheiro dos

    2010-01-01

    Full Text Available Ameloblastoma desmoplásico (AD é uma rara variante do ameloblastoma, com características clínicas, imaginológicas e histopatológicas específicas. O perfil biológico deste tumor não é totalmente compreendido, devido ao número limitado de casos notificados. O objetivo deste trabalho é relatar um caso de AD simulando uma lesão periapical. Este tumor apareceu na região anterior da maxila esquerda numa paciente do gênero feminino de 24 anos de idade, entre o incisivo lateral esquerdo e o canino. A lesão era indolor e apresentava apenas um ligeiro inchaço da mucosa do palato duro. Radiograficamente, uma área radiolúcida bem delimitada que promovia a divergência radicular foi observada. O incisivo lateral respondeu negativamente aos testes pulpares. Diagnóstico provisório de cisto radicular versus cisto fissural foi estabelecido e enucleação cirúrgica seguida de curetagem foi realizada. O exame histológico das amostras revelou a proliferação dos ninhos e cordões de epitélio odontogênico comprimido imersos em um estroma densamente colagenizado, associada a um trabeculado ósseo levemente irregular. Estas características eram consistentes com AD. A necrose pulpar do incisivo e o aparecimento radiográfico atípico, deixava a doença em absconso. Apesar das altas taxas de recorrência, nenhum sinal clínico ou radiográfico de recidiva do tumor foi detectado um ano mais tarde

  3. Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study

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    Santosh Hunasgi

    2013-01-01

    Full Text Available Aims. The aim is to present a case of rare giant granular cell ameloblastoma and to review the pertinent literature highlighting the molecular aspects of its pathogenesis by analyzing the expression of CD-68, Bcl-2, and β-catenin. Methods. H and E stained sections showed large odontogenic islands showing peripheral ameloblast-like cells and central stellate reticulum-like cells with extensive granular cell transformation surrounded by fibrous stroma. Polyclonal rabbit anti-CD 68, anti-Bcl2, and anti-β-catenin were stained immunohistochemically. Results. CD-68 showed a moderate to strong staining intensity in granular cells. Moderate staining of Bcl-2 was expressed by the peripheral columnar cells of tumor islands and negative in the granular cells. Expression of β-catenin was generally weak, except for only the focal areas that showed a moderate staining intensity and weak in peripheral cells. Conclusion. The present case of giant granular cell ameloblastoma is a rare entity. Development of monstrous size is indicative of ameloblastomas persistent growth. Granular cell transformation in ameloblastomas probably occurs as a consequence of extensive molecular changes. Immunohistochemical studies help us to know the pathogenesis of this granular cell ameloblastoma. Therefore, an effort has been made here to study the expression of Bcl-2, CD-68, and β-catenin.

  4. Conservative management of unicystic ameloblastoma in a young child: Report of two cases

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    Ritesh Kalaskar

    2011-01-01

    Full Text Available Unicystic ameloblastoma is a rare, benign, locally invasive odontogenic neoplasm of young age that show clinical, radiographic, or gross features of an odontogenic cyst, but histologically shows typical ameloblastomatous epithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth. The article presents atypical cases of a large, asymptomatic unicystic ameloblastoma of posterior maxilla and mandibular molar-ramus regions which were treated by surgical enucleation and application of Carnoy′s solution for 3 min. The article also describes the importance and complexity of differential diagnosis of an odontogenic lesion sharing common clinical and radiographical features.

  5. Oral Verrucous Carcinoma and Ameloblastoma: A Rare Coincidence

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    Zohreh Dalirsani

    2015-03-01

    Full Text Available Introduction: Oral verrucous carcinoma (OVC is a rare malignancy of the oral cavity that was first described by Ackerman. This tumor is a well-differentiated low-grade, slow growing cancer that is locally invasive without metastasis. Ameloblastoma is one of the most common odontogenic tumors, which originates from the odontogenic epithelium. Verrucous carcinoma along with central ambloblastoma is a rare phenomenon.   Case Report: A case of verrucous carcinoma along with central ambloblastoma in a 49-year-old man, which was referred with a painless exophytic lesion with a verrucous and granular surface, is reported.  Panoramic radiography revealed a well-defined radiolucency with sclerotic borders. To the best available knowledge, this phenomenon has not yet been reported.   Conclusion:  Verrucous carcinoma could occur in the wall of odontogenic cysts and tumors and should be considered during the differential diagnosis of a radiolucency, which is observed in the jaws with rapid growth or which presents some changes from its previous appearance. 

  6. Orthodontic occlusal reconstruction after conservative treatment of unicystic ameloblastoma in an adolescent patient: 10-year follow-up.

    Science.gov (United States)

    Tomita, Yuko; Kuroda, Shingo; Takahashi, Takumi; Ohura, Ritsuko; Tanaka, Eiji

    2013-09-01

    Conservative treatment of an ameloblastoma often requires an occlusal reconstruction. In this article, we report the successful interdisciplinary treatment of a 14-year-old girl with a unicystic ameloblastoma in the mandible. One year after the marsupialization, enucleation with bone curettage was performed with extraction of the impacted third molar, but the proximal second molar could be maintained. The conservative treatment required long-term use of an obturator, and it caused a total open bite. Additionally, the patient genetically had a Class II malocclusion with severe crowding. Consequently, orthodontic treatment was performed after 4 premolar extractions. There was no recurrence of the ameloblastoma 10 years after the enucleation.

  7. Peripheral desmoplastic ameloblastoma in adolescent age: clinico-pathological and immunohistochemical analisys of a case.

    Science.gov (United States)

    Oteri, Giacomo; Lentini, Maria; Pisano, Michele; Cicciù, Marco

    2014-01-01

    The Extraosseous or Peripheral Ameloblastoma (PA) is a rare and benign odontogenic tumour, representing 1% to 5% of all ameloblastomas. It is usually localized in the soft oral tissues, without deep bone involvement. Its biological behaviour is specific, and several authors define PA as a non-infiltrating hamartomatous lesion. Indeed, recurrences rarely occur and progression in malignant tumors appears to be rare. The PA originates from the tooth-forming apparatus and it consists of proliferating odontogenic epithelium, exhibiting the same histological cell types and patterns of the intraosseous counterpart or infiltrating ameloblastoma. The peripheral desmoplastic ameloblastoma (PDA) can be classified as a newly recognized and very rare histological variant. To our knowledge, only a few cases of adult patients affected by PDA have been published. The aim of this paper is to report a case of PDA affecting an adolescent patient. The clinical-pathological and immunohistological features are discussed in order to improve knowledge regarding a correct diagnosis and to differentiate PDA lesions from similar diseases.

  8. Expression of the stem cell marker, SOX2, in ameloblastoma and dental epithelium.

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    Juuri, Emma; Isaksson, Sanna; Jussila, Maria; Heikinheimo, Kristiina; Thesleff, Irma

    2013-12-01

    Ameloblastomas are locally invasive odontogenic tumors that exhibit a high rate of recurrence and often associate with the third molars. They are suggested to originate from dental epithelium because the tumor cells resemble epithelial cells of developing teeth. Expression of the transcription factor SOX2 has been previously localized in epithelial stem and progenitor cells in developing teeth as well as in various tumors. Here, we show that SOX2 is expressed in the epithelial cells of follicular and plexiform ameloblastomas. SOX2 was localized in the dental lamina of developing human primary molars. It was also expressed in the fragmented dental lamina associated with the third molars and in the epithelium budding from its posterior aspect in mice. However, no SOX2 expression was detected in either Hertwig's epithelial root sheath directing the formation of roots or in the epithelial cell rests of Malassez covering the completed roots. SOX2 was associated with supernumerary tooth formation in odontoma-like tumors induced by Wnt signal activation in mice. We propose that SOX2 functions in maintaining the progenitor state of epithelium in ameloblastomas and that ameloblastomas may originate from SOX2-expressing dental lamina epithelium.

  9. Surgical planning for resection of an ameloblastoma and reconstruction of the mandible using a selective laser sintering 3D biomodel.

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    Sannomiya, Eduardo Kazuo; Silva, Jorge Vicente L; Brito, Antonio Albuquerque; Saez, Daniel Martinez; Angelieri, Fernanda; Dalben, Gisele da Silva

    2008-07-01

    Ameloblastoma is a benign locally aggressive infiltrative odontogenic lesion. It is characterized by slow growth and painless swelling. The treatment for ameloblastoma varies from curettage to en bloc resection, and the reported recurrence rates after treatment are high; the safety margin of resection is important to avoid recurrence. Advances in technology brought about great benefits in dentistry; a new generation of computed tomography scanners and 3-dimensional images enhance the surgical planning and management of maxillofacial tumors. The development of new prototyping systems provides accurate 3D biomodels on which surgery can be simulated, especially in cases of ameloblastoma, in which the safety margin is important for treatment success. A case of mandibular follicular ameloblastoma is reported where a 3D biomodel was used before and during surgery.

  10. Allelic loss of the ING gene family loci is a frequent event in ameloblastoma.

    Science.gov (United States)

    Borkosky, Silvia S; Gunduz, Mehmet; Beder, Levent; Tsujigiwa, Hidetsugu; Tamamura, Ryo; Gunduz, Esra; Katase, Naoki; Rodriguez, Andrea P; Sasaki, Akira; Nagai, Noriyuki; Nagatsuka, Hitoshi

    2010-01-01

    Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors that physically and functionally interact with p53 to perform important roles in apoptosis, DNA repair, cell cycle regulation, and senescence. TP53 genetic alterations were reported to infrequently occur in ameloblastoma. Considering that other TSGs related to TP53 could be altered in this tumor, we focused our study on the ING family genes. We analyzed the loss of heterozygosity (LOH) status of the ING family (ING1-ING5) chromosomal loci in a group of ameloblastomas by microsatellite analysis, and correlated the ING LOH status with clinicopathological characteristics. By using specific microsatellite markers, high frequency of LOH was found at the loci of each ING gene family member (33.3-72.2%). A significant relationship was shown between LOH of D2S 140 (ING5 locus) and solid tumor type (p = 0.02). LOH of ING3MS (ING3 locus) was also high in solid type tumors, showing a near significant association. In addition, a notable tendency toward higher LOH for half of the markers was observed in recurrent cases. LOH of ING family genes appears as a common genetic alteration in solid ameloblastoma. The current study provides interesting novel information regarding the potential prognostic significance of the allelic loss of the ING gene family loci in ameloblastoma tumorigenesis.

  11. Ameloblastoma in the Northeast region of Brazil: A review of 112 cases

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    Santos, Thiago de Santana; Piva, Marta Rabello; Andrade, Emanuel Sávio de Souza; Vajgel, André; Vasconcelos, Ricardo José de Holanda; Martins-Filho, Paulo Ricardo Saquete

    2014-01-01

    Context: Ameloblastomas are benign tumors of the jaws with locally invasive capacity. Aim: The aim of this study was to review 112 cases of ameloblastoma seen over an 18-year period (1992-2009) at the Pernambuco Dental School, University of Pernambuco and at Federal University of Sergipe, in the northeast region of Brazil. Materials and Methods: The following data were selected for analysis: age, gender, race, site distribution, radiographic appearance, association with an impacted tooth, size, presence of symptoms, clinicopathologic subtypes and recurrence. Settings and Design: In this retrospective study, Pearson's χ2 test and t-test were employed. The critical level of significance was set at P < 0.05. Results: The mean age of the patients at presentation was 35.1 ± 16.8 years with a slight female preference. The peak prevalence was in the 11- to 20-year age group and declined with increasing age. Total 75 patients were black and 37 were white, for a 2:1 black: white ratio. The location of the ameloblastomas showed a marked predominance in the mandible (84.8%) and 69% of the cases presented with a multilocular radiographic appearance. The tumor was associated with an embedded tooth in 14 cases (12.7%): nine unilocular and five multilocular ameloblastomas. The maximum radiological extension of the lesions on panoramic radiographs was 0.5-20 cm (mean ± SD: 5.2 ± 3.3 cm) and most cases were symptom-free (75.9%). Solid/multicystic ameloblastoma was the most common clinicopathologic subtype. There was an association between the clinicopathologic subtypes and radiographic appearance (P < 0.001). Recurrence was observed in 13.3% of cases. Conclusion: We propose that racial factors may have strong influence on the incidence of ameloblastomas in the northeast region of Brazil, since most people have African descent. Data related to gender, location, radiographic appearance, size, symptoms, clinicopathologic subtypes and recurrence were similar to previous studies

  12. Analysis of Prevalence and Clinical Features of Ameloblastoma and its Histopathological Subtypes in Southeast Myanmar and Lower Northern Thailand Populations: A 13-Year Retrospective Study

    Science.gov (United States)

    2017-01-01

    Introduction Prevalence of ameloblastomas has been established worldwide but collective data of ameloblastoma in Southeast Asian countries has not been well analyzed. Aim Aim of this study was to report analysis and comparison of the prevalence and demographic data of clinical features of ameloblastoma and its histopathological variants in Southeast Myanmar and lower Northern Thailand populations. Materials and Methods A retrospective study on ameloblastoma was performed based on the availability of oral biopsy specimens in Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand, between January 2002 and August 2015. The collected data were subjected to descriptive statistical analyses with the SPSS version 17.0 statistical software package (SPSS Inc., Chicago, USA). Pearson’s chi square (χ2) test and t-test were employed. The critical level of significance was set at p<0.05. Results Total of 616 cases were reviewed, 30 cases (5%) were diagnosed as ameloblastoma with male:female ratio of 1.14:1. The mean age of the patients was 31.3±15.6 years. The predominance anatomical distribution was observed in the mandible (86.7%). Posterior body-ramus-angle region was the most common site. Almost all cases were asyptomatic and most common clinical manifestation was swelling of affected region. Multilocular radiolucency was observed in 70% of cases, whereas 30% were unilocular. Three subtypes of ameloblastomas were diagnosed: unicystic ameloblastoma (20%), conventional solid/multicystic ameloblastoma (70%), and desmoplastic ameloblastoma (10%). The most common histologic pattern was the plexiform type (57.2%) followed by follicular type (23.8%). Conclusion Prevalence of ameloblastoma in Southeast Myanmar and lower Northern Thailand populations correspond with data from other geographic areas of Thailand and other Asian countries. However, some demographic and histopathological profiles are different, with plexiform ameloblastoma being the most common subtype in

  13. Computed tomographic and magnetic resonance imaging of ameloblastoma: 2 case reports

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    Oder, P.; Royster, A. [Boston Medical Center, Dept. of Radiology, Boston, Massachusetts (United States); Gibbons, D. [Boston Medical Center, Dept. of Pathology, Boston, Massachusetts (United States); Mulligan, N.; Kavanagh, P.; Eustace, S. [Boston Medical Center, Dept. of Radiology, Boston, Massachusetts (United States)

    1999-12-01

    Cysts of the mandible are uncommon. Most arise from epithelium lining the alveolus or root of the tooth (tooth derivatives), and the rest arise from the cortical and cancellous osseous matrix of the mandible. Of cysts arising from the alveolus (odontogenic epithelium), radicular cysts are the most common, accounting for almost 90% of cases. They are almost always found either in association with a dental cavity or at the base of a devitalized, amalgam-filled tooth. Of the remaining 10% of cases, most are dentigerous cysts, arising from the outer epithelial lining of the developing tooth, which is displaced to the base of the cyst as the lesion grows. Ameloblastoma, which also arises from odontogenic epithelium, accounts for less than 1% of cases. In this case report, we review the imaging appearance, histology and management of this uncommon tumour. In doing so, we highlight signal characteristics on magnetic resonance imaging (MRI) that may allow noninvasive characterization of ameloblastoma before surgical resection. (author)

  14. Análise imuno-histoquímica das citoqueratinas em ameloblastoma e tumor odontogênico adenomatóide Immunohistochemical analysis of cytokeratins in ameloblastoma and adenomatoid odontogenic tumor

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    Fernanda Ferreira Lopes

    2005-12-01

    Full Text Available OBJETIVO: O presente trabalho teve por objetivo traçar o perfil das citoqueratinas (CKs 7, 8, 10, 13, 14, 18 e 19 em ameloblastomas e tumor odontogênico adenomatóide (TOA visando contribuir para o entendimento da histogênese desses tumores e somar com os resultados já relatados na literatura. MATERIAL E MÉTODO: do arquivo do Laboratório de Anatomia Patológica do Departamento de Odontologia da Universidade Federal do Rio Grande do Norte (UFRN foi selecionada uma amostra com dez casos de ameloblastomas e oito de TOA para o estudo imuno-histoquímico, utilizando-se anticorpos anti-CKs pelo método da estreptoavidina-biotina. RESULTADOS: Observou-se que nos ameloblastomas a CK 14 esteve presente em todos os casos, enquanto a CK 19 foi observada nas células periféricas (oito casos e nas centrais (cinco casos. Para os TOA, observou-se imunopositividade para a CK 14 em todos os casos, enquanto a CK 19 esteve marcada predominantemente nas células ductais (seis casos. CONCLUSÃO: As citoqueratinas são expressas de forma variada nos ameloblastomas e nos TOA, os quais preservam CK típicas do germe dental em estágios avançados do desenvolvimento, confirmando sua origem exclusiva a partir do epitélio odontogênico e não se evidenciando CK características do epitélio escamoso.OBJECTIVES: The aim of the present study was to describe the immunohistochemical expression of cytokeratins (CKs 7, 8, 10,13, 14, 18 and 19 in the epithelial components of ameloblastomas and adenomatoid odontogenic tumor (AOT. The results were compared and histogenesis discussed. MATERIAL AND METHOD: Specimens of ten ameloblastomas and eight adenomatoid odontogenic tumors were examined by immunohistochemistry using streptavidin-biotin-peroxidase complex method and anti-CKs antibody. The sample was obtained from Department of Oral Pathology, Federal University of Rio Grande do Norte. RESULTS: Immunohistochemical reactivity for CK14 was detected in all cases of

  15. Desmoplastic ameloblastoma in Indians: Report of five cases and review of literature

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    Sivapathasundharam B

    2007-01-01

    Full Text Available In the recent World Health Organization classification of odontogenic tumours, desmoplastic ameloblastoma has been characterized as a variant of ameloblastoma, with specific clinical, radiographical, and histological features. Till date, 145 cases have been reported in Japanese, Chinese, Malaysian, Western, and African populations, with very few cases described in Indians. Here, we report five cases in the Indian population. The male to female ratio was 3:2. The mean age at diagnosis was 33.2 years. Four of the tumours were located in the maxilla, in the anterior premolar region. The lone mandibular tumour was located anteriorly, crossing the midline. Three of the tumours had a mixed radiologic appearance with poorly defined borders. Unilocular change was seen in one of them. Two tumours presented as unilocular radiolucencies with specks of radiopacities and well-circumscribed borders. Histologically, irregular odontogenic islands, with a stretched-out ′kite-tail′ appearance, were seen in a dense desmoplastic stroma. The peripheral layer of the epithelial islands was made up of flattened cells and the inner core was made up of spindle-shaped and, in some instances, squamous-shaped cells. In two cases, odontogenic epithelium in the form of follicles, typical of solid/multicystic ameloblastoma, was seen and these were typed as ′hybrid′ variants. All the cases were treated by resection.

  16. Review of six cases of maxillary ameloblastoma from the West Indies: re-entry cryosurgery as prophylactic surgical intervention.

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    Ogunsalu, C; Scipio, E; Williams, N

    2009-09-01

    Maxillary ameloblastoma is a rare histopathological entity. A total of six cases of histologically confirmed maxillary ameloblastoma from the West Indies is reviewed. Three of the cases were taken from a total of 47 histologically confirmed ameloblastoma over a 15-year period (1980-1995) from two major maxillofacial units in Jamaica. Two other cases were from documentation in Jamaica between 2000 and 2002, one of which occurred in a 13-year-old girl (these two patients have been followed-up periodically to 2006). The sixth case was from the records of the maxillofacial department of the University of the West Indies in Trinidad and Tobago. This last patient, at a recent review, has inoperable recurrence. These cases were reviewed with respect to demographics (patient's age and gender), location and extent of tumour, radiological features, concurrent involvement of the mandible, treatment with special emphasis on current treatment modality and follow-up. The findings do not differ from what has been documented by other authors from other parts of the world. Because of the radiographic anatomy of the maxilla, recurrence may be detected late despite such occurring earlier following initial surgical management. It is for this reason that we suggest re-entry cryosurgery for prevention of recurrence for maxillary ameloblastoma. The only case of maxillary ameloblastoma that had re-entry cryosurgery continues to benefit from absence of recurrence at periodic follow-ups at four years post-primary surgical management (which was enucleation).

  17. Presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) in ameloblastomas correlate with rupture of the osseous cortical.

    Science.gov (United States)

    Fregnani, Eduardo Rodrigues; Sobral, Lays M; Alves, Fabio Abreu; Soares, Fernando Augusto; Kowalski, Luis Paulo; Coletta, Ricardo D

    2009-06-01

    Myofibroblasts are frequent in the stroma of neoplasm and by the expression of proteinases they can influence tumor infiltration and progression. In the present study, presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) and urokinase plasminogen activator (uPA) were examined in intra-osseous solid multicystic ameloblastomas to determine their roles in the clinicopathological features of the tumors. Fifty seven ameloblastomas were analyzed immunohistochemically with antibodies against the isoform alpha of the smooth muscle actin (alpha-SMA), a specific marker of myofibroblasts, MMP-2 and uPA. Myofibroblasts were found in the stroma, in close contact with neoplastic cell islands, of approximately 58% (n = 33) of the ameloblastomas. MMP-2 and uPA were found in the cytoplasm of both neoplastic and stromal cells. A significant correlation between presence of myofibroblasts and MMP-2 expression was observed. Abundant presence of myofibroblast in the stroma of the tumors and expression of MMP-2 in the neoplastic or stromal cells were significantly correlated with rupture of the osseous cortical, which has been considered an important prognostic marker of ameloblastoma aggressiveness. Ours results suggest that abundant presence of myofibroblasts and expression of MMP-2 in solid ameloblastomas may be associated with a more aggressive infiltrative behavior.

  18. Hemimandibulektomi dengan Rekonstruksi Mandibula dan Fiksasi Intermaksila sebagai Penatalaksanaan Ameloblastoma Mandibula Sinistra

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    Indria Nehriasari

    2012-12-01

    Full Text Available Latar belakang. Ameloblastoma adalah tumor odontogenik yang jarang terjadi. Walaupun jinak tetapi bersifat merusak dan mempunyai tingkat kekambuhan yang tinggi. Hemimandibulektomy adalah salah satu tindakan yang dipilih jika lesi patologis telah melibatkan processus coronoideus dan condyle walaupun efek dari tindakan tersebut adalah terjadinya defek wajah dan deviasi mandibula. Tujuan. Melaporkan tindakan hemimandibulektomy dengan rekonstruksi bridging plate dan traksi intermaksila pada ameloblastoma mandibula sebelah kiri yang dilakukan untuk mengurangi deviasi dan defek wajah. Kasus dan perawatan. Laki-laki umur 46 tahun datang ke klinik bedah mulut dan maksilofacial RS Dr Sardjito Yogyakarta dengan keluhan utama adanya pembengkakan pada sisi kiri rahang bawah di area pipi. Keadaan tersebut dirasakan sejak 4 tahun yang lalu, tidak sakit, keras, warna sesuai dengan jaringan sekitar. Diagnosa yang ditegakkan Ameloblastoma mandibula. Perawatan dari kasus ini adalah hemimandibulektomy dengan rekonstruksi bridging plate dengan anestesi umum. Enam minggu dengan kawat dan 3 bulan dengan traksi elastic digunakan untuk mengurangi deviasi mandibula setelah tulang rahang direseksi. Kesimpulan. Hemimandibulektomi dilakukan untuk mengambil lesi patologi secara radikal untuk mencegah rekurensi. Bridging plate digunakan sebagai tindakan rekontruksi mandibula. Traksi intermaksila merupakan salah satu cara yang bisa digunakan untuk mengurangi deviasi mandibula setelah hemimandibulektomy.   Background. Ameloblastoma is an odontogenic tumor which rarely happened. Although it is benign, it can be destructive and has a high recurrency rate. Hemimandibulectomy is one kind of treatments which can be choosed if pathologic fracture has involved coronoid processus and condyle, eventhough its effect can cause mandible deviation and facial defect. Purpose. Reported a hemimandibulectomy with bridging plate reconstruction and intermaxillary function on the left mandible

  19. Concomitant treatment of mandibular ameloblastoma and bilateral temporomandibular joint osteoarthritis with bone graft and total joint prostheses.

    Science.gov (United States)

    Rodrigues, Daniel B; Wolford, Larry M; Malaquias, Pietry; Campos, Paulo S F

    2015-01-01

    Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease that can create clinical problems in the masticatory musculature, jaws, occlusion, and other associated structures and is commonly accompanied by inflammatory changes and pain. Many cases of TMJ dysfunction can be managed with nonsurgical therapies, but patients with irreversible TMJ damage may require surgical intervention for repair or reconstruction. Despite various methods of TMJ reconstruction, the patient-fitted total joint prostheses may be the best option to achieve good outcomes. Multicystic ameloblastoma is a benign odontogenic neoplasm of the jaws that is found most often in the mandible, in the region of the molars, and the ramus. Ameloblastomas usually progress slowly, but are locally invasive and may cause significant morbidity and sometimes death. This report describes a case of concomitant treatment of recurrent mandibular ameloblastoma and severe bilateral TMJ osteoarthritis treated by resection of the tumor, reconstruction with bone grafting, and bilateral TMJ reconstruction in a 63-year-old woman.

  20. Ameloblastoma uniquístico, bases del tratamiento conservador: Presentación de caso clínico y actualización bibliográfica Single cyst ameloblastoma, basis of conservative treatment: Presentation of a clinical case and update of the literature

    Directory of Open Access Journals (Sweden)

    J. Argandoña Pozo

    2010-06-01

    Full Text Available El ameloblastoma se define como un tumor localmente agresivo e infiltrante, con una alta capacidad de recidiva. Este comportamiento agresivo e infiltrante plantea la problemática de una opción conservadora o radical de tratamiento, con las alteraciones funcionales, estéticas y psicológicas que esta última alternativa implica. El ameloblastoma uniquístico se describe como una lesión con cuadros morfológicos particulares, un comportamiento biológico menos agresivo que el ameloblastoma común, y una menor recurrencia frente a la terapia conservadora. Se presenta un caso clínico con el diagnóstico de ameloblastoma uniquístico tratado de forma conservadora mediante descompresión y posterior enucleación. Se actualiza la información sobre su tratamiento.The ameloblastoma it's defined as a localy aggressive neoplasm with a high incidence to local recurrence. This aggressive behaviour gives two options: a conservative treatment or a radical one, with all the functional, aesthetic and psychological alterations this implies. The unicyst ameloblastoma it's described as a disease with particular morphological aspects, a less aggressive biological behaviour than the common ameloblastoma, and less chances to reappear after a conservative treatment. Here we present a case of unicyst ameloblastoma treated in a conservative way by decompresion and resection. A review of the actual treatment methods.

  1. Estudo clínico, imaginológico, histopatológico e imunohistoquímico de ameloblastomas submetidos à descompressão

    OpenAIRE

    Bernabé, Daniel Galera

    2005-01-01

    Propósito: Investigar a efetividade da descompressão no tratamento inicial de ameloblastomas e os efeitos desse tipo de tratamento conservador nas características histopatológicas e de proliferação celular do tumor. Materiais e Métodos: Foram estudados retrospectivamente 8 pacientes portadores de ameloblastoma de mandíbula procedentes da Faculdade de Odontologia de Araçatuba-UNESP e do Hospital das Clínicas da FMUSP, sendo 4 ameloblastomas unicísticos e 4 multicísticos que tiveram como tratam...

  2. Clinicopathological and demographic characteristics of ameloblastomas in a population from Bahia, Brazil = Características clinicopatológicas e demográficas de ameloblastomas em uma população da Bahia, Brasil

    Directory of Open Access Journals (Sweden)

    Santos, Jean Nunes dos

    2010-01-01

    Conclusão: O perfil clínico- epidemiológico dos pacientes do presente estudo é similar ao de outras populações. Em adição, o ameloblastoma unicístico é o subtipo histológico mais comum em nossa população

  3. Ameloblastoma plexiforme del maxilar: manejo quirúrgico y protético. A propósito de un caso Plexiform ameloblastoma in the maxilla: surgical and prosthetic management. With reference to one case

    Directory of Open Access Journals (Sweden)

    F Carini

    2007-02-01

    Full Text Available El ameloblastoma es un tumor odontógeno benigno de derivación epitelial, de elevada invasión local, crecimiento intermitente y con alta probabilidad de recidiva. Puede dividirse en los siguientes tipos histológicos: folicular, plexiforme, acantomatoso, a células basales y granulares. El ameloblastoma folicular es el subtipo histológico más común. Se manifiesta prevalentemente durante la tercera, cuarta y quinta década de vida, sin predilección para el sexo, aun así se puede encontrar en cualquier grupo de edad incluyendo niños. La mayoría de los ameloblastomas se encuentra sobretodo en mandíbula (al nivel del ángulo y rama. Las características clínicas, incluso si complementadas con radiografías y muestras histológicas, no son útiles a la hora de predeterminar el comportamiento biológico y por lo tanto el pronóstico de un ameloblastoma individual. Los autores presentan un caso localizado de ameloblastoma plexiforme localizado en la parte posterior del maxilar de un hombre de 30 años; el término "plexiforme" se refiere al aspecto de anastomosis de los islotes del epitelio odontógeno, en contraste con el tipo «folicular». En este artículo se discuten importantes aspectos de la patología, del tratamiento quirúrgico y protésico. En conclusión, es necesaria una cooperación estricta a largo plazo de un grupo de clínicos, patólogos, cirujanos y prostodoncistas, para ofrecer el mejor tratamiento individualizado en cada caso.The ameloblastoma is a clinically persistent benign tumor derived from odontogenic epithelium, locally invasive, intermittent in growth and with high a probability of recurrence. The following histologic patterns may be distinguished: follicular, plexiform, spindle cell, acanthomatous, basal cell type and granular cell. The follicular ameloblastoma is the most common histologic tipe. The majority of patients are in 3th, 4th and 5th decade, but can be found in any age group including children. The

  4. Clinicopathological evaluation of 164 dental follicles and dentigerous cysts with emphasis on the presence of odontogenic epithelium in the connective tissue. The hypothesis of "focal ameloblastoma"

    NARCIS (Netherlands)

    Meleti, M.; van der Waal, I.

    2013-01-01

    Objectives: Some ameloblastomas presumably originate from odontogenic epithelium within the connective tissue of dental follicles and dentigerous cysts. Therefore, it would seem reasonable to discuss as whether odontogenic epithelium proliferations, frankly displaying ameloblastomatous features ("fo

  5. Marsupialization of unicystic ameloblastoma: A conservative approach for aggressive odontogenic tumors

    Directory of Open Access Journals (Sweden)

    Dogan Dolanmaz

    2011-01-01

    Full Text Available Unicystic ameloblastoma (UA is known as a distinct entity which has a less aggressive behavior when compared with conventional ameloblastoma. In this report, we have presented two cases of UAs, (of which one case showed a more aggressive behavior with mural invasion into the adjacent tissues and granular cell differentiation, both of which were successfully managed with enucleation following marsupialization. We aim to highlight how this method can be used for the successful management of such cases, rather than following more aggressive approaches. In both the cases, marsupialization was done for the UA lesions initially and follow-ups were maintained. When the tumor size had regressed on radiographic follow up, an enucleation procedure with ostectomy of the margins was carried out. Special importance was also given to the endodontic treatment of the teeth involved in the area of the lesion. The patients were free of the condition and did not show any signs of recurrence on radiographic follow-ups even after 30 months of the final procedure. Granular variant of UA is quite rare and had been considered to be more aggressive. Marsupialization of UA is an alternative treatment option of resection even for more aggressive variants, as long as the histological behavior of the lesion was carefully evaluated and strict radiographic follow-up is maintained.

  6. Two stage enucleation and deflation of a large unicystic ameloblastoma with mural invasion in mandible.

    Science.gov (United States)

    Sasaki, Ryo; Watanabe, Yorikatsu; Ando, Tomohiro; Akizuki, Tanetaka

    2014-06-01

    A treatment for strategy of unicystic ameloblastoma (UA) should be decided by its pathology type including luminal or mural type. Luminal type of UA can be treated only by enucleation alone, but UA with mural invasion should be treated aggressively like conventional ameloblastomas. However, it is difficult to diagnose the subtype of UA by an initial biopsy. There is a possibility that the lesion is an ordinary cyst or keratocystic odontogenic tumor, leading to a possible overtreatment. Therefore, this study performed the enucleation of the cyst wall and deflation at first, and the pathological finding confirmed mural invasion into the cystic wall, leading to the second surgery. The second surgery enucleated scar tissue, bone curettage, and deflation, and was able to contribute to the reduction of the recurrence rate by removing tumor nest in scar tissue or new bone, enhancing new bone formation, and shrinking the mandibular expanding by fenestration. In this study, a large UA with mural invasion including condyle was treated by "two-stage enucleation and deflation" in a 20-year-old patient.

  7. Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

    Directory of Open Access Journals (Sweden)

    Shubhagata Das

    2013-08-01

    Full Text Available A 6 year old female Spitz dog was admitted to Teaching Veterinary Hospital at Chittagong Veterinary and Animal Sciences University with the history of inappetance and asymmetric lower jaw. Oral inspection revealed a pair of pale enlarged lobulated mass around the third molar tooth of the left mandible. The dog was clinically diagnosed with epulis and successfully cured by surgical excision. Histopathological section of the excised masses revealed characteristic features of acanthomatous ameloblastoma with some atypical lesions. Multifocal areas of ameloblastic islands were found in the dense sheet of proliferating epithelial layer protruding towards the sub epithelial connective tissue stroma. These islands were characterized with irregular epithelial stratification at the basal layer. Besides, presence of ghost cells was the unusual findings for such case. Prominent intercellular bridging and nuclear polymorphism in odontogenic cells were other decisive characters of the lesion. Based on the histomorphological appearance, the gingival tumor was designated as canine acanthomatous ameloblastoma (CAA with atypical histomorphology. [Vet World 2013; 6(4.000: 219-222

  8. The expression of calretinin and cytokeratins in canine acanthomatous ameloblastoma and oral squamous cell carcinoma.

    Science.gov (United States)

    Fulton, A; Arzi, B; Murphy, B; Naydan, D K; Verstraete, F J M

    2014-12-01

    Oral squamous cell carcinoma (OSCC) and canine acanthomatous ameloblastoma (CAA) represent two epithelium-derived neoplasms that affect the oral cavity of dogs. The expression of cytokeratins (CKs) and calretinin has been previously established in the canine tooth bud and odontogenic tumours. The aim of this study was to characterize the CK and calretinin expression profile of OSCC in comparison to CAA and canine tooth bud tissues. Samples from 15 OSCC and 15 CAA cases, as well as 6 tooth buds and 2 normal gingival tissues were examined. OSCC CK expression was consistent with the CK expression profile of CAA and canine tooth bud tissue. Calretinin was positively expressed in 10 of 15 OSCC cases, with 5 cases demonstrating high staining intensity. Only 2 of 15 CAA cases demonstrated mild-moderate staining intensity. The statistically significant difference in staining pattern and intensity of calretinin in OSCC and CAA can help distinguish between these two tumour types.

  9. Non-Invasive Implanto Prosthetic Rehabilitation in the Lower Arch Subsequent to Ameloblastoma Removal. A Case Report

    OpenAIRE

    Alberto Maltagliati; Samer Helal Zaky; Andrea Ottonello

    2015-01-01

    Aim: Describing the surgical/therapeutic and the prosthetic/functional approaches for the treatment and rehabilitation of a patient with an ameloblastoma in the posterior area of mandible. Materials and Methods: Enucleation of the lesion took place by surgical resection with bone margin extending to more than 1 cm beyond the lesion’s macroscopic margins, without performing guided bone regeneration. A year after surgery, a panoramic radiograph (OPG) was performed and seve...

  10. Receptors for the lectins wheat germ. Ricinus communis I and soybean in ameloblastomas and normal oral mucosa.

    Science.gov (United States)

    Vedtofte, P; Dabelsteen, E

    1981-11-01

    The histological distribution of receptors for the lectins Wheat germ (WGA). Ricinus communis I (RCA I) and Soybean (SBA) was examined in ameloblastomas and normal oral mucosa from 12 patients. The study utilized fluorescein-conjugated WGA, RCA I and SBA. Cell-membrane bound receptors for these 3 lectins were demonstrated in the spinous cell layer of the normal oral mucosa. WGA and RCA I receptors were also located in the basal cell layer, whereas SBA receptors were not detectable there. Cell-membrane bound WGA receptors were shown in the epithelial cells of the ameloblastomas. Titrations showed significant differences in staining reactivity related to the morphology of the peripheral epithelial cells of the ameloblastomas. The distribution of RCA I and SBA receptors in the peripheral cells was also related to the morphology of these cells and was independent of the histological types of the tumours. It is suggested that the distribution of these receptors is related to cellular activities such as cell differentiation and cell migration in the tumour and therefore possibly reflects the biological behavior of the tumours.

  11. Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma.

    Science.gov (United States)

    Sánchez-Romero, Celeste; Bologna-Molina, Ronell; Mosqueda-Taylor, Adalberto; Paes de Almeida, Oslei

    2016-08-01

    Hypoxia-inducible factor-1α (HIF-1α) promotes proteins that enable cell survival during hypoxia, such as glucose transporter 1 (GLUT-1). Their coexpression has been associated with aggressiveness in malignancies and has not been studied in odontogenic tumors. Immunohistochemical expression of HIF-1α and GLUT-1 was analyzed in 13 tooth germs (TGs), 55 ameloblastomas (AMs), and 3 ameloblastic carcinomas (ACs). HIF-1α was negative in all TGs, and just 1 case of AM and 1 of AC had nuclear positivity. GLUT-1 expressed in ameloblastic cells of all TGs, AMs, and ACs, with an increasing intensity, respectively, and was significantly higher in solid AM than in unicystic AM (P = .041). Absence of nuclear HIF-1α in TGs and most AMs suggest that GLUT-1 may be induced by alternative pathways to hypoxia. However, in ACs, HIF-1α may be activated; however, to confirm this, additional cases are needed. GLUT-1 overexpression could be related to aggressiveness in AMs and ACs and must represent a normal metabolite in TGs.

  12. Enriched vascularity in ameloblastomas, an indeterminate entity: Report of two cases

    Directory of Open Access Journals (Sweden)

    Usha Hegde

    2015-01-01

    Full Text Available Vascularity is a highly essential element that is required for the growth, development, and functioning of the body and variations in it can cause pathologies. It is one of the prime features of a proliferating lesion, where it aids in the growth of the lesion through its nutrition supply. Highly increased vascularity in a disease can itself affect the prognosis of the lesion, and in malignancies, it can induce tumor seeding and secondaries. Most of the pathologies including tumors, related to blood vessels, and vascularity are well established. There are some conditions, wherein altered vascularity is one of the prime components along with other diagnostic components of an established disease. In such cases, these lesions are diagnosed with special names, with varying biological behavior and prognosis in comparison to that of established entity. However, there still are few similar conditions whose nature is uncertain due to the rarity of the lesion and the insufficient scientific evidence which eludes the diagnostician. Here is the report of two cases of ameloblastoma, an established entity, with significant vascularity whose nature is indeterminate.

  13. Glandular odontogenic cyst mimicking ameloblastoma in a 78 year old female: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do; Lee, Wan; Kwon, Kyung Hwan; Choi, Moon Ki; Choi, Eun Joo [College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Yoon, Jung Hoon [Dept. of Oral and Maxillofacial Pathology, College of Dentistry, Daejeon Dental Hospital, Wonkwang University, Daejeon (Korea, Republic of)

    2014-09-15

    Glandular odontogenic cyst (GOC) is a rare, potentially aggressive jaw lesion. The common radiographic features include a well-defined radiolucency with distinct borders, presenting a uni- or multilocular appearance. A cystic lesion in the posterior mandible of a 78-year-old female was incidentally found. Radiographs showed a unilocular lesion with a scalloped margin, external root resorption of the adjacent tooth, and cortical perforation. This lesion had changed from a small ovoid shape to a more expanded lesion in a period of four years. The small lesion showed unilocularity with a smooth margin and a well-defined border, but the expanded lesion produced cortical perforation and a lobulated margin. The provisional diagnosis was an ameloblastoma, whereas the histopathological examination revealed a GOC. This was a quite rare case, given that this radiographic change was observed in the posterior mandible of an elderly female. This case showed that a GOC can grow even in people in their seventies, changing from the unilocular form to an expanded, lobulated lesion. Here, we report a case of GOC with characteristic radiographic features.

  14. Immunoexpression of Wnt/β-catenin signaling pathway proteins in ameloblastoma and calcifying cystic odontogenic tumor

    Science.gov (United States)

    Dutra, Sabrina-Nogueira; Pires, Fábio-Ramôa; Armada, Luciana

    2017-01-01

    Background Wnt/β-catenin signaling pathway is essential for the beginning of odontogenesis and may be involved in the development and progression of some odontogenic tumors. Thus, the aim of this study was to comparatively evaluate the immunohistochemical expression of Wnt/β-catenin signaling pathway proteins in a series of AME and CCOT. Material and Methods Immunohistochemical reactions were performed using antibodies against Wnt1, Wnt5a and β-catenin in 17 cases of solid AME and 6 cases of CCOT. Results In the AME group, Wnt1 and Wnt5a were identified in the epithelium in most of the cases, and β-catenin was mainly identified in the cytoplasm of the tumoral cells. In the CCOT group, Wnt1 and Wnt5a were identified in the epithelium and in the ghost cells in almost all the cases, and β-catenin was mainly identified in the cytoplasm and in the nuclei of the tumoral cells. Conclusions These results contribute to support the importance of Wnt/β-catenin signaling pathway proteins in AME and CCOT tumorigenesis. The abnormal expression of cytoplasmic and/or nuclear β-catenin appears to contribute to the development of both AME and CCOT. In addition, it is possible that Wnt1 and Wnt5a expression in ghost cells can contribute to its histogenesis in CCOT. Key words:Ameloblastoma, β-catenin, calcifying cystic odontogenic tumor, immunohistochemistry, Wnt. PMID:28149478

  15. Estudo retrospectivo dos casos diagnosticados como ameloblastoma no Serviço de Anatomia Patológica do Hospital Universitário Antônio Pedro entre 1997 e 2007 A retrospective study of ameloblastoma in the Anatomic Pathology Service of Antônio Pedro University Hospital between 1997 and 2007

    Directory of Open Access Journals (Sweden)

    Daniela Otero Pereira da Costa

    2008-12-01

    Full Text Available INTRODUÇÃO: O ameloblastoma é um tumor odontogênico de origem epitelial que, pela freqüência, subtipos clínicos, grande capacidade infiltrativa e alta tendência à recorrência tem merecido bastante atenção. OBJETIVO:Realizar estudo retrospectivo dos casos diagnosticados histopatologicamente de ameloblastoma no Serviço de Anatomia Patológica do Hospital Universitário Antônio Pedro da Universidade Federal Fluminense (HUAP/UFF no período de 1997 a 2007. Material e métodos: Foram selecionados casos de ameloblastoma correspondentes ao período da pesquisa, e dados como idade, sexo, raça, localização da lesão, aspecto radiográfico, tipo de biópsia, diagnósticos clínico e histopatológico foram compilados das fichas de requisição e/ou prontuários. RESULTADOS:Depois do levantamento e da revisão das lâminas para confirmação do diagnóstico de ameloblastoma, a amostra totalizada foi de 23 casos. Os pacientes mais acometidos eram do sexo masculino, leucodermas e estavam entre a primeira e a terceira década de vida. Todos os casos ocorreram na mandíbula, sendo a região posterior a mais afetada. Predominaram o aspecto radiográfico multilocular e, histopatologicamente, o padrão multicístico, sendo os subtipos folicular e híbrido os mais freqüentes. Não foram observados casos de ameloblastoma desmoplásico e de células basais. CONCLUSÕES: A freqüência do ameloblastoma varia de acordo com a região geográfica avaliada, e a realização de estudos retrospectivos pode contribuir para a identificação de grupos e dos possíveis fatores associados ao seu desenvolvimento.BACKGROUND: Ameloblastoma is an odontogenic tumor of epithelial origin that has received considerable attention due to its frequency, clinical subtypes and high tendency to infiltrate and recur. OBJECTIVE: To perform a retrospective study of cases histopathologically diagnosed of ameloblastoma at the Pathological Anatomy Department of APUH/UFF-RJ from

  16. Evaluación mediante radiología, tomografía computarizada y resonancia magnética de un ameloblastoma sólido. Reporte de un caso

    OpenAIRE

    Ruiz-Imbert, Ana Cecilia; Facultad de Odontología, Universidad de Costa Rica. San José,; Calderón-Ubaqui, Víctor; Asociación Peruana de Radiología Bucal y Maxilofacial. Lima,; Delgado-Azañero, Wilson; Facultad de Estomatología Roberto Beltrán, Universidad Peruana Cayetano Heredia. Lima,; Ruiz-García, Vilma Elizabeth; Asociación Peruana de Radiología Bucal y Maxilofacial. Lima,; Trevejo-Bocanegra, Ana Paola; Asociación Peruana de Radiología Bucal y Maxilofacial. Lima,; Ventura-Ponce, Helard; Asociación Peruana de Cirugía Bucal y Maxilofacial. Lima,; Huamaní-Parra, Jaime; Servicio de Cirugía Oral y Maxilofacial. Hospital Nacional Cayetano Heredia. Lima,

    2014-01-01

    De acuerdo con la Organización Mundial de la Salud (OMS), el ameloblastoma es un tumor odontogénicobenigno, siendo una de sus variantes intraóseas más frecuentes el ameloblastoma sólido o multiquístico, el cualtiene un comportamiento local agresivo por su capacidad de alcanzar grandes dimensiones y desplazar estructurasanatómicas vecinas. Se reporta el caso de un paciente masculino que presentaba un ameloblastoma sólido en lamandíbula, de 7 años de evolución, que producía marcada asimetría fa...

  17. Rare copy number alterations and copy-neutral loss of heterozygosity revealed in ameloblastomas by high-density whole-genome microarray analysis

    DEFF Research Database (Denmark)

    Diniz, Marina Gonçalves; Duarte, Alessandra Pires; Villacis, Rolando A

    2017-01-01

    BACKGROUND: Ameloblastoma (unicystic, UA, or multicystic, MA) is a rare tumor associated with bone destruction and facial deformity. Its malignant counterpart is the ameloblastic carcinoma (AC). The BRAFV600E mutation is highly prevalent in all these tumors subtypes and cannot account for their d...

  18. Ameloblastoma multiquístico mandibular tratado con terapia menos invasiva: Caso clínico y revisión de la literatura Multicystic ameloblastoma of the mandible treated by less invasive therapy: clinical case and review of the literature

    Directory of Open Access Journals (Sweden)

    Rodrigo López Alvarenga

    2010-12-01

    Full Text Available El ameloblastoma es un tumor odontogénico benigno, localmente invasivo y recidivante, que constituye aproximadamente el 10% de los tumores odontogénicos. Estos tumores ocurren más frecuentemente en la mandíbula. El cuadro clínico se caracteriza generalmente por presentar deformaciones faciales, crecimiento lento y asintomático. El tratamiento depende del tipo, la localización y el tamaño del tumor, así como de la edad del paciente. En este artículo se presenta un caso de ameloblastoma multiquístico en la mandíbula, que implica a una paciente del sexo femenino de 57 años, en el cual se discuten los aspectos diagnósticos e histopatológicos, así como el tratamiento menos invasivo empleado en el caso.Ameloblastoma is a benign odontogenic tumor, locally invasive and recurrent, representing approximately 10% of odontogenic tumors. The majority of cases occur in the mandible with slow and asymptomatic growth that can lead to facial deformities. The treatment of choice is based upon on the type, location and size of the tumor, as well as the age of the patient. A case of multicystic ameloblastoma of the mandible affecting a 57 years old female patient is presented discussing the diagnostic, histological, and less invasive treatment used in the case.

  19. Ameloblastoma desmoplásico con predominio quístico: Presentación de un caso clínico

    Directory of Open Access Journals (Sweden)

    Begoña Martínez-Revilla

    2016-07-01

    Full Text Available El ameloblastoma es una neoplasia odontogénica que muestra un comportamiento agresivo local. Algunas variantes como la uniquística y la desmoplásica tienen un mejor pronóstico que la sólida/multiquística. Presentamos un caso en un varón de 76 años con una lesión radiolúcida interradicular mandibular de apariencia quística, la cual se enucleó quirúrgicamente. Histológicamente correspondió a una lesión desmoplásica con una amplia zona quística que fue diagnosticada como ameloblastoma desmoplásico con predominio quístico. Trascurridos 30 meses no se evidencia recidiva. En este artículo se discuten los principales aspectos clinicopatológicos de estas entidades.

  20. Tratamento cirúrgico do ameloblastoma com reconstrução de mandíbula com enxerto de crista ilíaca não vascularizado: estudo de sete casos Surgical treatment of the ameloblastoma of the mandible and reconstruction with non vascularized iliac crest graft: study of seven cases

    Directory of Open Access Journals (Sweden)

    Daniela Venturoli Lunardi

    2001-02-01

    Full Text Available OBJETIVO: Determinar a validade do enxerto autólogo de crista ilíaca não vascularizado no tratamento cirúrgico do ameloblastoma de mandíbula. MÉTODO: Nos Serviços de Cirurgia de Cabeça e Pescoço e Semiologia Bucal do Complexo Hospitalar Heliópolis, de 1980 a 2000, foram tratados 31 pacientes com ameloblastoma de mandíbula, dos quais sete receberam enxerto de crista ilíaca autólogo, fixos com placa de titânio do sistema A-0 (quatro casos e aço inox (três casos, sendo portadores da variedade folicular (seis casos e plexiforme (um caso. RESULTADOS: Nesta análise, foi utilizado o Teste de Hipótese para a média populacional com a variança desconhecida, houve exposição da placa em três casos (40% quando a neoplasia ultrapassava a linha média e em quatro casos (60% não incidiu nenhuma complicação. CONCLUSÕES: Apesar da incidência de exposição de placa, o método é indicado na reconstrução da mandíbula de pacientes com ameloblastoma.BACKGROUND: To determine of the real validity of non vascularized iliac crest graft in the surgical treatment of ameloblastoma of the mandible. METHODS: From 1980 to 2000, at the Head and Neck and Oral Semiology Services of Heliópolis Hospital, 29 patients were submitted to differents approaches, from which 7 received a non-vascularized autologus iliac crest graft fixed with A-0 titanium (4 cases or inox (3 cases systems plates for folicular (6 cases and plexiform (1 case ameloblastomas. RESULTS: We used a test of hypothesis for the population mean with unknown in variance. There was plate exposition in 3 cases (40%, when the tumor overpass midline, and complete sucess in 4 cases (60% with no complications of this reconstructive approach for mandible ameloblastoma. CONCLUSIONS: In spite of the incidence of plate expesure, this technique is indicated for mandible reconstruction in patients with amelablastoma.

  1. Estudo retrospectivo dos casos diagnosticados como ameloblastoma no Serviço de Anatomia Patológica do Hospital Universitário Antônio Pedro entre 1997 e 2007

    OpenAIRE

    Costa,Daniela Otero Pereira da; Ecard,Marcelle Bairral; Oliveira, Silvia Paula de; Silva,Licínio Esmeraldo da; Dias, Eliane Pedra; Lourenço,Simone de Queiroz Chaves

    2008-01-01

    INTRODUÇÃO: O ameloblastoma é um tumor odontogênico de origem epitelial que, pela freqüência, subtipos clínicos, grande capacidade infiltrativa e alta tendência à recorrência tem merecido bastante atenção. OBJETIVO:Realizar estudo retrospectivo dos casos diagnosticados histopatologicamente de ameloblastoma no Serviço de Anatomia Patológica do Hospital Universitário Antônio Pedro da Universidade Federal Fluminense (HUAP/UFF) no período de 1997 a 2007. Material e métodos: Foram selecionados cas...

  2. Spontaneous multi-cystic peripheral ameloblastoma in the freshwater angelfish, from the Brazilian state of Pará

    Directory of Open Access Journals (Sweden)

    M. Videira

    2015-08-01

    Full Text Available Este trabalho registra a ocorrência espontânea de ameloblastoma em P. scalare. O tumor foi obtido a partir de um exemplar de Acará Bandeira, sendo fixado, seccionado, e os fragmentos processados para microscopia de luz e microscopia eletrônica de varredura (MEV. O exame macroscópico evidenciou uma massa tumoral que se estendia do rebordo alveolar do maxilar superior à face externa labial. À MEV, a neoplasia apresentou uma série de espículas. Microscopicamente, percebia-se um processo neoplásico constituído por tecido conjuntivo de característica mixoide, ricamente vascularizado, onde eram observados fragmentos de tecido osteoide. A amostra revelou proliferação neoplásica do epitélio odontogênico, onde as células neoplásicas se organizavam na forma de paliçada. Alterações histopatológicas em peixes têm sido úteis biomarcadores do efeito à exposição a substâncias tóxicas, sendo as neoplasias lesões específicas, comumente encontradas em peixes de áreas poluídas, revelando uma associação entre as lesões e a exposição a irritantes.

  3. Comparison of immunoexpression of VEGF, TGF-β and MMP-9 in ameloblastoma and adenomatoid odontogenic tumor = Comparação da imunoexpressão de VEGF, TGF-β e MMP-9 em ameloblastoma e tumor odontogênico adenomatóide

    Directory of Open Access Journals (Sweden)

    Ferreira, Stefânia Jeronimo

    2015-01-01

    Full Text Available Objetivo: Estudos sobre tumores odontogênicos têm identificado várias disfunções moleculares envolvidas no seu desenvolvimento, e alguns mecanismos como a angiogênese e modulação da matriz são objetos úteis para investigar as diferenças no comportamento biológico destes tumores. Alguns marcadores importantes para identificar a agressividade do tumor por imunoistoquímica são as proteínas VEGF, TGF-ß e MMP-9. Este estudo teve como objetivo comparar a expressão imunoistoquímica de VEGF, TGF-ß e MMP-9 entre ameloblastoma e tumor odontogênico adenomatoide (TOA. Métodos: Imunoexpressão de VEGF, TGF-ß e MMP-9 foi estudada em 15 ameloblastomas sólidos e 15 TOA. Uma análise semiquantitativa das células imunomarcadas foi realizada e a análise estatística foi feita usando o teste não paramétrico de Mann-Whitney e o teste de correlação de Spearman, com nível de significância de 0,05 (P0. 05. Conclusão: Os resultados sugerem o envolvimento da angiogênese na progressão tumoral de ameloblastomas e o efeito indutor de células estromais em TOA, portanto, justificando o seu potencial de crescimento mais baixo

  4. Assessment of quality of life and sociocultural aspects in patients with ameloblastoma after immediate mandibular reconstruction with a fibular free flap.

    Science.gov (United States)

    Zhu, Juanfang; Yang, Yanjie; Li, Wenlu

    2014-02-01

    Our aim was to evaluate the quality of life (QoL) in patients with ameloblastoma who had been treated by immediate mandibular reconstruction with a fibular free flap, and to analyse the association between QoL and their sociocultural and medical characteristics. We assessed the QoL outcomes of 33/45 patients using the University of Washington quality of life (UW-QoL) questionnaire and the 14-item Oral Health Impact Profile (OHIP-14). Thirty-three of the 45 questionnaires were returned (73%). In the UW-QoL the best-scoring domain was "shoulder", whereas the lowest scores were for "chewing" and "activity". In the OHIP-14 the lowest-scoring domain was "handicap", followed by "social disability" and "psychological discomfort". Mandibular reconstruction with a fibular free flap significantly influenced the patients' QoL and oral function. Their sociocultural data showed that most patients had a fairly low level of education.

  5. Five years follow-up of implant-prosthetic rehabilitation on a patient after mandibular ameloblastoma removal and ridge reconstruction by fibula graft and bone distraction

    Directory of Open Access Journals (Sweden)

    Giacomo Oteri

    2012-01-01

    Full Text Available This case report presents a combination of surgical and prosthetic solutions applied to a case of oral implant rehabilitation in post-oncologic reconstructed mandible. Bone resection due to surgical treatment of large mandibular neoplasm can cause long-span defects. Currently, mandibular fibula free flap graft is widely considered as a reliable technique for restoring this kind of defect. It restores the continuity of removed segment and re-establishes the contour of the lower jaw. However, the limited height of grafted fibula does not allow the insertion of regular length implants, therefore favouring vertical distraction osteogenesis as an important treatment choice. This report presents a patient affected by extensive mandibular ameloblastoma who underwent surgical reconstruction by fibula free flap because of partial mandibular resection. Guided distraction osteoneogenesis technique was applied to grafted bone, in order to obtain adequate bone height and to realize a prosthetically guided placement of 8 fixtures. After osseointegration, the patient was rehabilitated with a full arch, screw-retained prosthetic restoration. At five-years follow up, excellent integration of grafted tissue, steady levels of bone around the fixtures and healthy peri-implant tissues were reported.

  6. Histogenesis and cell differentiation of desmoplastic ameloblastoma%促结缔组织增生型成釉细胞瘤的组织发生与细胞分化机制探讨

    Institute of Scientific and Technical Information of China (English)

    李江; 张伟国

    2001-01-01

    目的:探讨促结缔组织增生型成釉细胞瘤(desmoplastic ameloblastoma,DA)的组织发生与细胞分化机制。方法:对20例DA中不同类型的蛋白细丝的表达进行免疫组化检测,并对4例DA进行超微结构观察。结果:免疫组化标记表明,肿瘤上皮中梭形、多边形细胞CKH、CK8、CK19呈不同程度阳性,间质中纤维细胞vimentin阳性,部分间质细胞smooth muscle actin阳性。超微结构观察见肿瘤上皮细胞内存在张力丝,细胞间见桥粒连接,间质中见肌纤维母细胞,部分上皮巢周围组织疏松。结论:DA可能为牙胚发生较早阶段发生的肿瘤,且肿瘤上皮有向角化细胞分化的倾向。%Objective:To study the histogenesis and cell differentiation of desmoplastic ameloblastoma.Methods:The expression of various protein filaments was detected by immunohistochemical stainning in 20 cases of desmoplastic ameloblastoma and the ultrastructure of the tumor was observed in 4 cases.Results:CKH,CK8 and CK19 were positive in spindle-shaped and polygonal epithlium tumor cells.Vimentin was positive in mesenchymal fibrocytes and smooth muscle actin in some mesenchymal cells.Ultrastructural observation found that tonifilaments were in epithelial cells and there were desmosomes between these cells.In stroma myofibroblasts were presented.Loose connective tissue could be seen around some epithelial cell nests.Conclusion:Desmoplastic ameloblastoma may be arise from the early stage of the dental germ formation, epithelial cells of the tumor had the tendency to differentiate to the keratinized cells.

  7. Tumor odontogênico cístico calcificante com proliferação ameloblastomosa em seio maxilar Calcifying cystic odontogenic tumor with ameloblastoma proliferation in the maxillary sinus

    Directory of Open Access Journals (Sweden)

    Maria Carolina Gonçalves Carnasciali

    2012-08-01

    Full Text Available O tumor odontogênico cístico calcificante (TOCC com proliferação ameloblastomosa é uma variante rara entre os cistos maxilares. Este trabalho objetiva apresentar o relato clínico de um paciente do sexo masculino, 18 anos de idade, que apresentava aumento de volume extra e intraoral do lado esquerdo da maxila, firme à palpação, de característica normocrômica e indolor. A conduta consistiu em realização de tomografia Cone Beam, biópsia incisional, remoção completa da lesão, curetagem e fixação maxilar. O paciente encontra-se em acompanhamento clínico e radiográfico sem recidiva após doze meses. Dessa forma, ressalta-se a importância do diagnóstico precoce, a conduta clínica empregada e o acompanhamento periódico.Calcifying cystic odontogenic tumors (CCOT with proliferative ameloblastoma are a rare variant among maxillary cysts. This study aims to present a clinical report of an 18-year-old male patient with extra and intra oral swelling of the left maxilla, firm to touch, with normochromic characteristics and painless. The clinical approach comprised cone-beam tomography, incisional biopsy, complete removal of the lesion, curettage and maxilla fixation. His clinical and radiographic follow-up has revealed no relapse after 12 months. Hence, this study corroborates the importance of early diagnosis, clinical approach and periodical follow-ups.

  8. 成釉细胞瘤中bmp2基因突变的发现%Gene mutation of bmp2 in ameloblastoma

    Institute of Scientific and Technical Information of China (English)

    岳文; 杨连甲; 朱峰; 晏伟

    2000-01-01

    目的:分析成釉细胞瘤组织中bmp2成熟肽基因片段的序列,探讨bmp2基因突变存在的可能性以明确其病理机制.方法:提取肿瘤组织中的RNA,用RT-PCR方法得到bmp2成熟肽基因片段,克隆后进行序列测定和分析.结果:首次发现成釉细胞瘤组织中有bmp2基因突变:AAG→AAA,GAG→AAG,并引起相应多肽的结构改变.结论:成釉细胞瘤中存在bmp2基因突变,并有可能在病理机制中起重要作用.

  9. McCune-Albright综合征伴牙源性角化囊肿及成釉细胞瘤1例报道%McCune-Aibright Syndrome with Odontogenic Keratocyst and Ameloblastoma: case report

    Institute of Scientific and Technical Information of China (English)

    龚大东; 王绪凯; 徐中飞; 孙宁宁

    2009-01-01

    McCune-Albright综合征(McCune-Albright Syndrome)是一种罕见的鸟嘌呤核苷酸结合蛋白(G蛋白)病,临床以多发性骨纤维异常增殖症、皮肤斑片状色素沉着及性早熟为最常见症状。口腔颌面部常可表现为硬组织的病变和面部畸形。有些患者唇颊黏膜有色素沉着,牙齿提前萌出等症状。我院收治1例,报告如下。

  10. Carcinoma ameloblástico de la mandíbula

    Directory of Open Access Journals (Sweden)

    Angel Lazo- Valladares

    2005-07-01

    Full Text Available El concepto de carcinoma intraóseo primario es exclusivo de la mandíbula y maxila, ya que se origina de componentes ondontogénicos. El carcinoma ameloblástico es una lesión sumamente infrecuente, que puede aparecer de novo o asociado a una lesión previa, como un quiste odontogénico o un ameloblastoma. El diagnóstico se establece cuando se encuentran elementos histológicos de ameloblastoma, que alternan con áreas de epitelio histológicamente malignas, con independencia de que existan metástasis. Esto lo diferencia del también infrecuente ameloblastoma metastático, en el cual se encuentra un ameloblastoma con histología benigna, que inesperadamente mestatiza. La importancia de esta diferenciación radica en el pronóstico, ya que el carcinoma ameloblástico es una lesión muy agresiva, de crecimiento rápido, que tiende a provocar un gran efecto de masa, que tiene alta tasa de recidiva y mortalidad, contrario al ameloblastoma metastásico, caso en que el paciente puede sobrevivir muchos años tras la aparición de la metástasis. Con el presente caso se ilustran algunos aspectos importantes sobre el comportamiento biológico del ameloblastoma, como su elevado potencial de recurrencia, el daño que puede provocar por extensión directa y ciertas complicaciones metabólicas que, aunque infrecuentes, puede asociar. Además, permite diferenciar clínica e histológicamente la rara transformación maligna que este puede presentar, lo mismo que la importancia de la clasificación adecuada de los carcinomas odontogénicosThe concept of primary intraosseus carcinoma is exclusive of the mandible and maxilla because it originates from odontogenic components. The ameloblastic carcinoma is a very rare lesion that can appear de novo or arise form a previous lesion as an odontogenic cyst or ameloblastoma. The diagnosis is established when it is found histologic elements of an ameloblastoma together with histologically malignant epithelium

  11. EXPRESS AND ROLE OF MATRIX METALLOPROTEINASE-2 (MMP-2)、 TISSUE INHIBITOR OF METALLOPROTEINASE-2 (TIMP-2)、 MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE (MT1-MMP) mRNA IN AMELOBLASTOMA%成釉细胞瘤MMP-2、TIMP-2、MT1-MMP mRNA的表达和意义

    Institute of Scientific and Technical Information of China (English)

    张彬; 黄洪章; 潘朝斌; 陶谦

    2003-01-01

    目的探讨MMP-2、TIMP-2、MT1-MMP与成釉细胞瘤局部侵袭特性的生物学关系.方法采用RT-PCR方法检测基质金属蛋白酶及其抑制剂和激活剂MMP-2、TIMP-2、MT1-MMP在成釉细胞瘤的表达及含量.结果在成釉细胞瘤组织中,MMP-2、MT1-MMP、TIMP-2的mRNA均表达,且表达水平均显著高于正常牙囊组织,复发及实性成釉细胞瘤的TIMP-2、MT1-MMP相对含量均显著高于原发和囊性成釉细胞瘤.结论在成釉细胞瘤组织中,MMP-2、MT1-MMP、TIMP-2转录水平的增高可能与其侵袭特性有关,MT1-MMP/TIMP-2表达水平可能与其侵袭能力有关.

  12. A standardized formula for aesthetic mandibular reconstruction using an osteocutaneous fibular free flap.

    Science.gov (United States)

    Kim, Soung Min; Amponsah, Emmanuel K; Kim, Hui Young; Kwon, Ik Jae; Myoung, Hoon; Lee, Jong Ho

    2016-09-01

    Ameloblastoma is the most common benign odontogenic tumor of the jaw, and expansional growth of a huge untreated ameloblastoma can result in disturbances in facial aesthetics and function, such as difficulty with mouth opening, swallowing, chewing, breathing, neurologic deficits, and pathologic fractures. Radical wide resection with safety margins and subsequent reconstruction is generally recommended. A fibular free flap (FFF) is commonly used to reconstruct the mandible in order to adequately restore both aesthetic appearance and function. The aim of this brief clinical report is to present a case of huge ameloblastoma after wide resection with free safety margins, and describe the immediate one-step mandibular reconstruction using a vascularized composite FFF. The sterolithographic( rapid prototype, RP) model, a wax pattern of the resected mandible, and a surgical fibular stent made from the wax pattern were constructed preoperatively. We suggest a standardized surgical protocol for mandibular reconstruction with FFF.

  13. Carcinoma ameloblástico de la mandíbula

    Directory of Open Access Journals (Sweden)

    Angel Lazo- Valladares

    2005-07-01

    Full Text Available El concepto de carcinoma intraóseo primario es exclusivo de la mandíbula y maxila, ya que se origina de componentes ondontogénicos. El carcinoma ameloblástico es una lesión sumamente infrecuente, que puede aparecer de novo o asociado a una lesión previa, como un quiste odontogénico o un ameloblastoma. El diagnóstico se establece cuando se encuentran elementos histológicos de ameloblastoma, que alternan con áreas de epitelio histológicamente malignas, con independencia de que existan metástasis. Esto lo diferencia del también infrecuente ameloblastoma metastático, en el cual se encuentra un ameloblastoma con histología benigna, que inesperadamente mestatiza. La importancia de esta diferenciación radica en el pronóstico, ya que el carcinoma ameloblástico es una lesión muy agresiva, de crecimiento rápido, que tiende a provocar un gran efecto de masa, que tiene alta tasa de recidiva y mortalidad, contrario al ameloblastoma metastásico, caso en que el paciente puede sobrevivir muchos años tras la aparición de la metástasis. Con el presente caso se ilustran algunos aspectos importantes sobre el comportamiento biológico del ameloblastoma, como su elevado potencial de recurrencia, el daño que puede provocar por extensión directa y ciertas complicaciones metabólicas que, aunque infrecuentes, puede asociar. Además, permite diferenciar clínica e histológicamente la rara transformación maligna que este puede presentar, lo mismo que la importancia de la clasificación adecuada de los carcinomas odontogénicos

  14. Dentinoameloblastoma with ghost cells: A rare case report with emphasis on its biological behavior

    Directory of Open Access Journals (Sweden)

    Kiran Kumar

    2013-01-01

    Full Text Available Ameloblastomas are regarded as a homogeneous group of neoplasms with locally invasive character. They generally do not show induction of dental hard tissue formation except in few cases. Biological behavior and histogenesis of these tumors is still unexplored as there is lack of relevant studies and long follow-up of these patients. So, we aimed to report this rare case of dentinoameloblastoma with unique presence of ghost cells in middle-aged female involving maxilla with emphasis on its biological behavior. We conclude that although histogenesis of this tumor is not clear but biological potential is similar to conventional ameloblastoma requiring wider excision.

  15. Ameloblastic carcinoma: Secondary dedifferentiated carcinoma of the mandible: Report of a rare entity with a brief review

    Directory of Open Access Journals (Sweden)

    Siddharth Pundir

    2011-01-01

    Full Text Available Epithelial odontogenic tumors arise from odontogenic epithelial structures. Malignant epithelial odontogenic tumors are extremely rare. Ameloblastic carcinomas may present denovo, ex ameloblastoma or ex odontogenic cyst. Most ameloblastic carcinomas are presumed to present denovo. To date less than 45 cases of ameloblastoma with metastasis have been reported. It occurs primarily in the mandible in a wide range of age groups; no sex or race predilection has been noted. It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption, and tooth mobility. The lesion is usually found unexpectedly after an incisional biopsy or the removal of a cyst. Histologic features of ameloblastic carcinoma shows tumor cells that resemble the cells seen in ameloblastoma, but they show cytologic atypia. Moreover, they lack the characteristic arrangement seen in ameloblastoma. The clinical course of ameloblastic carcinoma is typically aggressive, with extensive local destruction. Here we describe a rare case of ameloblastic carcinoma (secondary dedifferentiated carcinoma of mandible in a 40-year-old female patient. Ameloblastic carcinoma: Secondary dedifferentiated carcinoma of the mandible.

  16. Peripheral dentinogenic ghost cell tumor

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    Sushant S Kamat

    2013-01-01

    Full Text Available Dentinogenic ghost cell tumors (DGCT are uncommon lesions mainly with rare peripheral types. This report presents a case of peripheral DGCT on the left side of the mandibular alveolar ridge of a heavy smoker, a 68-year-old man, with main presenting feature as a mild pain. Submandibular lymphadenopathy and radiological "saucerization" were evident. Differential diagnosis included fibroma, neurofibroma, peripheral ameloblastoma, peripheral odontogenic fibroma, and peripheral giant cell granuloma. Histologically, ameloblastoma-like epithelial elements were seen in association with grouped ghost cells. Proliferating polyhedral cells and stellate reticulum-like cells with various densities were spread over a wide range of the field. The lesion was curetted and after 2 years of follow up, it did not recur.

  17. A Rare Case Report of Spindle Cell Ameloblastic Carcinoma Involving the Mandible

    Science.gov (United States)

    Kunche, Arunodaya; Ananthaneni, Anuradha; Bagalad, Bhavana S; Kuberappa, Puneeth Horatti

    2017-01-01

    Ameloblastic Carcinoma (AC) is uncommon malignant epithelial odontogenic tumour of jaw, with characteristic histologic features and behavior. Clinically, it has aggressive, infiltrative growth pattern with a distinct predilection for mandible. It exhibits histologic features of ameloblastoma and gets dedifferentiated overtime to culminate in carcinoma. Majority of the cases arise denovo (primary) and only few cases arise from a pre-existing ameloblastoma (secondary). Spindle-cell differentiation in ameloblastic carcinoma is rare; Salter described it as a separate entity “low-grade spindle cell ameloblastic carcinoma. Here we report a case of 32-year-old female patient who presented with a swelling present for past six months. It was diagnosed as Spindle cell Ameloblastic Carcinoma (SpAC), after the hemimandibulectomy the patient was under regular follow up for 14 months, no sign of recurrence was seen. PMID:28274070

  18. Dentinogenic ghost cell tumor

    Directory of Open Access Journals (Sweden)

    Singhaniya Shikha

    2009-01-01

    Full Text Available Dentinogenic ghost cell tumor (DGCT is a rare tumorous form of calcifying odontogenic cyst and only a small number of cases have been described. It is a locally invasive neoplasm that is characterized by ameloblastoma-like epithelial islands, ghost cells and dentinoid. The present report describes a case of a 21-year-old male with a tumor in the posterior region of the mandible, showing features of DGCT.

  19. Decompression Device Using a Stainless Steel Tube and Wire for Treatment of Odontogenic Cystic Lesions: A Technical Report.

    Science.gov (United States)

    Jung, Eun-Joo; Baek, Jin-A; Leem, Dae-Ho

    2014-11-01

    Decompression is considered an effective treatment for odontogenic cystic lesions in the jaw. A variety of decompression devices are successfully used for the treatment of keratocystic odontogenic tumors, radicular cysts, dentigerous cysts, and ameloblastoma. The purpose of these devices is to keep an opening between the cystic lesion and the oral environment during treatment. The aim of this report is to describe an effective decompression tube using a stainless steel tube and wire for treatment of jaw cystic lesions.

  20. A study of biological chemistry on the nature of jaw cysts. On the maintainance of homoeostasis in jaw cyst fluid.

    Science.gov (United States)

    Suzuki, M

    1975-06-01

    Jaw cyst lining cells have an active transporting mechanism for Na+ ion and K+ion, a secreting mechanism and a selecting mechanism, and they allow permeation of electrolytes, lipids and protein into cysts. The components within the cysts have a controlling metabolism, and keep the system stable. Tumour wall cells of cystic ameloblastoma have only a passive transporting mechanism for various substances. Their nature differs from that of jaw cyst lining cells.

  1. Ameloblastomatous calcifying odontogenic cyst: A rare histologic variant

    Directory of Open Access Journals (Sweden)

    Basavaraj N Kallalli

    2015-01-01

    Full Text Available Ameloblastoma is a well-known odontogenic tumor that can be associated with calcifying odontogenic cysts (COCs, but only a few reports give its clinical and radiographic features. Calcifying odontogenic cyst was first categorized as a distinct entity by Gorlin et al., and has been named after him since then. Calcifying odontogenic cyst is an uncommon developmental odontogenic lesion that demonstrates histopathologic diversity. It is well known that this lesion can occur in association with odontogenic tumors such as complex odontoma and ameloblastoma. The term COC was not included by the World Health Organization (WHO in its report of 2005 and is called calcifying cystic odontogenic tumor (CCOT. Histopathologic examination of ameloblastomatous CCOT reveals ameloblastic islands containing ghost cells. Although association of ameloblastoma with this lesion is important, only a few cases have been reported in literature. The present case report is of ameloblastomatous calcifying cystic odontogenic tumor, a rare histologic variant, in a 20-year-old male patient in the left mandibular posterior region.

  2. FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes

    Science.gov (United States)

    Kuga, Takahisa; Sasaki, Mitsuho; Mikami, Toshinari; Miake, Yasuo; Adachi, Jun; Shimizu, Maiko; Saito, Youhei; Koura, Minako; Takeda, Yasunori; Matsuda, Junichiro; Tomonaga, Takeshi; Nakayama, Yuji

    2016-01-01

    FAM83H is essential for the formation of dental enamel because a mutation in the FAM83H gene causes amelogenesis imperfecta (AI). We previously reported that the overexpression of FAM83H often occurs and disorganizes the keratin cytoskeleton in colorectal cancer cells. We herein show that FAM83H regulates the organization of the keratin cytoskeleton and maintains the formation of desmosomes in ameloblastoma cells. FAM83H is expressed and localized on keratin filaments in human ameloblastoma cell lines and in mouse ameloblasts and epidermal germinative cells in vivo. FAM83H shows preferential localization to keratin filaments around the nucleus that often extend to cell-cell junctions. Alterations in the function of FAM83H by its overexpression, knockdown, or an AI-causing truncated mutant prevent the proper organization of the keratin cytoskeleton in ameloblastoma cells. Furthermore, the AI-causing mutant prevents desmosomal proteins from being localized to cell-cell junctions. The effects of the AI-causing mutant depend on its binding to and possible inhibition of casein kinase I (CK-1). The suppression of CK-1 by its inhibitor, D4476, disorganizes the keratin cytoskeleton. Our results suggest that AI caused by the FAM83H mutation is mediated by the disorganization of the keratin cytoskeleton and subsequent disruption of desmosomes in ameloblasts. PMID:27222304

  3. A Contemporary Approach to Classify Ghost Cells Comprising Oral Lesions

    Science.gov (United States)

    Yadav, Sumit Kumar; Narwal, Anjali; Devi, Anju

    2015-01-01

    Ghost cells are swollen eosinophilic epithelial cells that have lost their nuclei but retain the cellular and nuclear outline. Pathologic ghost cell formation could be the process of aberrant keratinization or the result of coagulative necrosis. Ghost cells have been described in several odontogenic lesions, which include calcifying epithelial odontogenic cysts or tumours like odontomas, ameloblastic fibro-odontomas, and ameloblastomas. This article present a view on the formation of ghost cells with proposal/introduction of a classification for ghost cell lesions of the oral cavity in an attempt to organize these lesions for the better understanding and academic purpose. PMID:26501039

  4. [Benign odontogenic tumor in the lower jaw: A case report].

    Science.gov (United States)

    Bassetti, Renzo; Tomasetti, Patrick; Crameri, Manuel; Kuttenberger, Johannes

    2016-01-01

    Odontomas are classified within the group of odontogenic epithelial tumors with odontogenic ectomesenchyme with or without hard tissue formation. Together with ameloblastomas and keratocystic odontogenic tumors they are counted among the most common odontogenic tumors. Their growth is self-limiting and mostly, they are discovered accidentally as part of a x-ray examination. A common finding is that odontomas are associated with an unerupted permanent tooth. The aim of the present case report is to present the step-by-step procedure of a surgical odontoma removal in the lingual premolar/canine area of the lower jaw.

  5. Cyst or tumor in the buccomaxillary region: Review of literature and a case report

    Science.gov (United States)

    Raheel, Syed Ahmed; Kujan, Omar Bashar; Dwedary, Hisham Mohammed Najeeb; Sikander, Mohammed Hilal; Mankar, Sunil; Amrin, M. Nidha

    2015-01-01

    Odontogenic tumors (OTs) include entities of a hamartomatous nature, such as odontoma, benign neoplasms like an adenomatoid odontogenic tumor (AOT), some benign neoplasms are aggressive as in the case of ameloblastoma. The AOT is a rare odontogenic tumor constituting only 3% of all the OT and very often misdiagnosed as an odontogenic cyst. We report a case of an intra-osseous type of AOT occurred in a young 16-year-old female located in the anterior maxilla along with the clinical, radiological, histological features, and literature review related to the tumor affecting the patient. PMID:26538960

  6. Histopathological insight of complex odontoma associated with a dentigerous cyst.

    Science.gov (United States)

    Astekar, Madhusudan; Manjunatha, Bhari Sharanesha; Kaur, Prabhpreet; Singh, Jappreet

    2014-01-31

    Odontomas and dentigerous cysts are common findings for practicing dental professionals. However, simultaneous occurrence of pathologies like odontoma and dentigerous cyst are uncommon and their diagnosis based on the radiographic appearance alone is a challenge to overcome. They together are a potential for complications like attaining large size, root resorption, destruction of the jaw bones and sometimes neoplastic changes like ameloblastoma. This paper presents a case of complex odontoma associated with dentigerous cyst in relation to a retained deciduous tooth in the maxillary anterior region and confirming its diagnosis histopathologically.

  7. Odontoameloblastoma: Report of two cases

    Directory of Open Access Journals (Sweden)

    Mosca Rodrigo

    2009-01-01

    Full Text Available Odontoameloblastoma (OA is a very rare mixed odontogenic neoplasm, characterized by the simultaneous occurrence of an ameloblastoma and a compound or complex odontoma in the same tumor mass. To date, less than 50 cases of OA and/or ameloblastic odontoma have been reported in the English dental literature. This neoplasm was called ameloblastic odontoma. The term OA was included in the 1971 WHO classification. In this study, we present two cases of OA, which we hope will contribute to the awareness and knowledge of surgeons regarding the existence of this odontogenic tumor so that patients having it may be treated and followed-up properly.

  8. Imunolocalização da podoplanina em tumores odontogênicos benignos

    OpenAIRE

    Adriana dos Santos Caetano

    2011-01-01

    A podoplanina humana é uma glicoproteína que se expressa em várias células e tecidos normais e neoplásicos, inclusive aqueles de origem odontogênica. O objetivo deste estudo foi identificar a imunolocalização da podoplanina em tumores odontogênicos epiteliais com e sem ectomesênquima incluindo oito ameloblastomas, nove tumores odontogênicos adenomatóides, vinte tumores odontogênicos queratocísticos, cinco cistos odontogênicos ortoqueratinizados, um tumor odontogênico epitelial calcificante,...

  9. Odontogenic tumors: analysis of 127 cases Tumores odontogênicos: análise de 127 casos

    OpenAIRE

    Santos, Jean Nunes; Leão PEREIRA PINTO; Cláudia Roberta Leite Vieira de FIGUEREDO; DE SOUZA, LÉLIA BATISTA

    2001-01-01

    One hundred and twenty-seven cases of histologically confirmed odontogenic tumors were retrieved from a total of 5,289 oral and maxillary lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, during a period of 30 years (l970-l999). The most common histological diagnosis was odontoma (50.40%), followed by ameloblastoma (30.70%). The prevalence of odontogenic tumors was greater in females and the peak incidence occurred in the second and third decades ...

  10. Papilliferous Keratoameloblastoma: An Extremely Rare Case Report

    Directory of Open Access Journals (Sweden)

    Neeta Mohanty

    2013-01-01

    Full Text Available Odontogenic tumors develop in the jaw bones from the odontogenic tissue-oral epithelium in tooth germ, enamel organ, dental papilla, reduced enamel epithelium, remnants of Hertwig’s root sheath or dental lamina, and so forth. Hence, a bewildering variety of tumors are encountered in the maxilla and mandible. Ameloblastoma is the second most common odontogenic neoplasm after odontomes, and it has numerous clinical and histologic variants. We report a very rare histologic variant: the papilliferous keratoameloblastoma which is the fifth reported case in the English literature.

  11. Cyst or tumor in the buccomaxillary region: Review of literature and a case report.

    Science.gov (United States)

    Raheel, Syed Ahmed; Kujan, Omar Bashar; Dwedary, Hisham Mohammed Najeeb; Sikander, Mohammed Hilal; Mankar, Sunil; Amrin, M Nidha

    2015-08-01

    Odontogenic tumors (OTs) include entities of a hamartomatous nature, such as odontoma, benign neoplasms like an adenomatoid odontogenic tumor (AOT), some benign neoplasms are aggressive as in the case of ameloblastoma. The AOT is a rare odontogenic tumor constituting only 3% of all the OT and very often misdiagnosed as an odontogenic cyst. We report a case of an intra-osseous type of AOT occurred in a young 16-year-old female located in the anterior maxilla along with the clinical, radiological, histological features, and literature review related to the tumor affecting the patient.

  12. Seguimiento de un fibroma ameloblástico con transformación maligna a fibrosarcoma ameloblástico.

    OpenAIRE

    Galindo Obando, Ursula; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Delgado Azañero, Wilson; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima.; Calderón Ubaqui, Víctor; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Beltrán Silva, Jorge; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Huamaní Parra, Jaime; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima.; Paniura Rodriguez, Dithel; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Anchayhua Espinoza, Miguel; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    La transformación maligna de un tumor odontogénico es poco común y puede desarrollarse a partir de un tumor odontogénico benigno. Se presenta el caso de una paciente de sexo femenino de 19 añosde edad, con el seguimiento secuencial de las radiografías y tomografía computarizada de una lesión inicialmente diagnosticada como Ameloblastoma, que posterior al tratamiento quirúrgico se establececomo Fibroma ameloblastico y al cabo de seis años sufre una transformación maligna determinado con un dia...

  13. Evaluation of Amelotin Expression in Benign Odontogenic Tumors

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    Daiana Paula Stolf

    2013-10-01

    Full Text Available Objective: Amelotin (AMTN is highly and selectively expressed by odontogenic epithelium-derived ameloblasts throughout the maturation stage of enamel formation. The protein is secreted and concentrated at the basal lamina interface between ameloblasts and the mineralized enamel matrix. Odontogenic tumors (OT are characterized by morphological resemblance to the developing tooth germ. OT vary from slowly expanding, encapsulated tumors to locally aggressive and destructive lesions. The purpose of this study was to determine the expression profile of AMTN in benign odontogenic tumors and to correlate it with specific features of the lesions. Methods: Immunohistochemical staining for AMTN was performed on human ameloblastoma, ameloblastic fibroma (AF, ameloblastic fibro-odontoma (AFO, odontoma, adenomatoid odontogenic tumor (AOT and calcifying cystic odontogenic tumor (CCOT. Results: Generally, ameloblastoma and AF did not stain for AMTN. A strong signal was detected in ameloblast-like layers of AFO and odontoma. Epithelial cells in AOT did not stain for AMTN, while calcifying areas of extracellular eosinophilic matrix were intensely stained. Interestingly, ghost cells present in odontomas and CCOT revealed variable staining, again in association with calcification foci. Conclusions: Amelotin expression was consistently detected in tumors presenting differentiated ameloblasts and obvious matrix deposition. Additionally, the presence of the protein in the eosinophilic matrix and small mineralized foci of AOT and calcification areas of ghost cells may suggest a role for AMTN in the control of mineralization events. [J Interdiscipl Histopathol 2013; 1(5.000: 236-245

  14. Jaw lesions associated with impacted tooth: A radiographic diagnostic guide

    Science.gov (United States)

    Mortazavi, Hamed

    2016-01-01

    This review article aimed to introduce a category of jaw lesions associated with impacted tooth. General search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks were used to find relevant studies using keywords such as "jaw lesion", "jaw disease", "impacted tooth", and "unerupted tooth". More than 250 articles were found, of which approximately 80 were broadly relevant to the topic. We ultimately included 47 articles that were closely related to the topic of interest. When the relevant data were compiled, the following 10 lesions were identified as having a relationship with impacted tooth: dentigerous cysts, calcifying odontogenic cysts, unicystic (mural) ameloblastomas, ameloblastomas, ameloblastic fibromas, adenomatoid odontogenic tumors, keratocystic odontogenic tumors, calcifying epithelial odontogenic tumors, ameloblastic fibro-odontomas, and odontomas. When clinicians encounter a lesion associated with an impacted tooth, they should first consider these entities in the differential diagnosis. This will help dental practitioners make more accurate diagnoses and develop better treatment plans based on patients' radiographs. PMID:27672610

  15. Frequency of Odontogenic Tumors in Zahedan-Iran from 2000 to 2010

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    Hamideh Kadeh

    2012-01-01

    Full Text Available Introduction: Odontogenic tumors constitute an important aspect of oral and maxillofacial pathology. Frequency of odontogenic tumors varies in different societies but no study has been done in Zahedan so far. The purpose of this study was to achieve the sex, location and age distribution of odontogenic tumors and frequency of each one in a period of ten years.Materials & Methods: In this study, documents in archive of maxillofacial pathology department of Zahedan dental school, Khatamolanbia, Tamin ejtemaei Hospital and private laboratories were reviewed from 2000 to 2010. Data about age, sex, location of tumors and relation with impacted tooth were extracted and were submitted in the forms.Results: In this study, among the 1125 cases of the oromaxillofacial lesions, 50 cases of odontogenic tumors were found. Among the different tumors, keratocyst odontogenic tumor (KOT was the most common odontogenic tumor (48%, followed by ameloblastoma and odontoma with frequency of 24% and 12%, respectively. There were no cases of malignancy. The incidence of these lesions was 52% in women and 48% in men. The most common location of tumors was posterior of mandible and tumors were more frequent in the third decade of life. In 12 cases, the lesions were accompanied by impacted teeth.Conclusion: In this study the most frequent tumors were KOT, Ameloblastoma and odontoma respectively.

  16. Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions

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    Saede Atarbashi Moghadam

    2013-01-01

    Full Text Available P63 may have a role in tumorigenesis and cytodifferentiation of odontogenic lesions. We investigated the immunohistochemical expression of P63 in a total of 30 cases of odontogenic cysts and tumors. The percentage of positive cells was calculated in the lining of odontogenic cysts and islands of ameloblastoma. P63 expression was evident in all types of odontogenic lesions. P63 was expressed throughout the lining epithelium of odontogenic keratocyst except surface parakeratinized layer. In addition, calcifying odontogenic cyst showed P63 expression in all layers. In almost all radicular and dentigerous cysts, the basal and parabasal layers were immunoreactive. Peripheral cells of ameloblastoma expressed P63; however, stellate reticulum had weaker immunostaining. No significant difference in P63 expression was observed between studied lesions (. Expression of P63 in odontogenic lesions suggests that this protein is important in differentiation and proliferation of odontogenic epithelial cells. However, it seems that it could not be a useful marker to differentiate between aggressive and nonaggressive lesions. P63 also represents a progenitor or basal cell marker, and it is not expressed in mature differentiated cells.

  17. Jaw lesions associated with impacted tooth: A radiographic diagnostic guide

    Energy Technology Data Exchange (ETDEWEB)

    Motazavi, Hamed; Bharvand, Maryam [Dept. of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2016-09-15

    This review article aimed to introduce a category of jaw lesions associated with impacted tooth. General search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks were used to find relevant studies using keywords such as 'jaw lesion', 'jaw disease', 'impacted tooth', and 'unerupted tooth'. More than 250 articles were found, of which approximately 80 were broadly relevant to the topic. We ultimately included 47 articles that were closely related to the topic of interest. When the relevant data were compiled, the following 10 lesions were identified as having a relationship with impacted tooth: dentigerous cysts, calcifying odontogenic cysts, unicystic (mural) ameloblastomas, ameloblastomas, ameloblastic fibromas, adenomatoid odontogenic tumors, keratocystic odontogenic tumors, calcifying epithelial odontogenic tumors, ameloblastic fibro-odontomas, and odontomas. When clinicians encounter a lesion associated with an impacted tooth, they should first consider these entities in the differential diagnosis. This will help dental practitioners make more accurate diagnoses and develop better treatment plans based on patients' radiographs.

  18. Bleomycin/interleukin-12 electrochemogenetherapy for treating naturally occurring spontaneous neoplasms in dogs.

    Science.gov (United States)

    Reed, S D; Fulmer, A; Buckholz, J; Zhang, B; Cutrera, J; Shiomitsu, K; Li, S

    2010-08-01

    On the basis of superior outcomes from electrochemogenetherapy (ECGT) compared with electrochemotherapy in mice, we determined the efficacy of ECGT applied to spontaneous canine neoplasms. Intralesional bleomycin (BLM) and feline interleukin-12 DNA injection combined with translesional electroporation resulted in complete cure of two recurrent World Health Organization stage T(2b)N(0)M(0) oral squamous cell carcinomas (SCCs) and one T(2)N(0)M(0) acanthomatous ameloblastoma. Three remaining dogs, which had no other treatment options, had partial responses to ECGT; one had mandibular T(3b)N(2b)M(1) melanoma with pulmonary and lymph node metastases; one had cubital T(3)N(0)M(1) histiocytic sarcoma with spleen metastases; and one had soft palate T(3)N(0)M(0) fibrosarcoma. The melanoma dog had decrease in the size of the primary tumor before recrudescence and euthanasia. The histiocytic sarcoma dog had resolution of the primary tumor, but was euthanized because of metastases 4 months after the only treatment. The dog with T(3)N(0)M(0) fibrosarcoma had tumor regression with recrudescence. Treatment was associated with minimal side effects and was easy to perform, was associated with repair of bone lysis in cured dogs, improved quality of life for dogs with partial responses and extended overall survival time. ECGT seems to be a safe and resulted in complete responses in SCC and acanthomatous ameloblastoma.

  19. Odontogenic tumors: analysis of 127 cases Tumores odontogênicos: análise de 127 casos

    Directory of Open Access Journals (Sweden)

    Jean Nunes SANTOS

    2001-12-01

    Full Text Available One hundred and twenty-seven cases of histologically confirmed odontogenic tumors were retrieved from a total of 5,289 oral and maxillary lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, during a period of 30 years (l970-l999. The most common histological diagnosis was odontoma (50.40%, followed by ameloblastoma (30.70%. The prevalence of odontogenic tumors was greater in females and the peak incidence occurred in the second and third decades of life. The main anatomical location was the mandible, and no malignant tumors were found.De uma série de 5.289 casos de lesões orais e dos maxilares diagnosticadas no Laboratório de Patologia Oral da Faculdade de Odontologia da Universidade Federal do Rio Grande do Norte no período de 30 anos (1970-1999, foram analisados 127 casos de tumores odontogênicos confirmados histologicamente. A lesão mais freqüente foi o odontoma (50,40% seguida pelo ameloblastoma (30,70%. A prevalência de tumores odontogênicos foi maior nas mulheres e o pico de incidência ocorreu na segunda e terceira décadas de vida. A localização anatômica mais comum foi a mandíbula e não foram encontrados casos de tumores malignos.

  20. Odontoameloblastoma: A case report

    Science.gov (United States)

    Negi, Amita; Puri, Abhiney; Nangia, Rajat; Sachdeva, Alisha

    2015-01-01

    Odontoameloblastoma (OA) is an extremely rare odontogenic tumor that contains an ameloblastomatous component together with odontoma-like elements. Till date, very few cases have fulfilled the criteria of the current World Health Organization classification of odontogenic tumors. It is characterized by slow, progressively growing lesion with growth pattern similar to solid multi-cystic ameloblastoma. The majority of the tumors are associated with unerupted teeth and commonly seen in males. It is usually asymptomatic and may occur in either maxilla or mandible, but shows a slight predilection for mandible. As this tumor is extremely rare, there exists controversy regarding its treatment. Here, we present a case of OA in 17-year-old female patient resembling a fibro-osseous lesion and a brief review of the related literature. PMID:26604505

  1. INTRAOSSEOUS AND EXTRAOSSEOUS VARIANTS OF DENTINOGENIC GHOST CELL TUMOR: TWO CASE REPORTS

    Directory of Open Access Journals (Sweden)

    Merva SOLUK TEKKESIN

    2015-01-01

    Full Text Available This paper aims to present both intraosseous and extraosseous variant of dentinogenic ghost cell tumor as well as a review of the literature. An 11-year old female patient presented a swelling and pain in the molar area of the mandible and a 15-year-old female patient reported a complaint of swelling in the right vestibular region of teeth 12 and 13(FDI 2-digit classification system. Microscopic examinations showed similar features which characterized by ameloblastoma-like islands of epithelial cells, containing numerous ghost cells. The patients have been disease-free for one year. This paper aims to describe this rare tumor and to increase the number of cases in the literature to better understand its biologic behavior and treatment options.

  2. A multilocular radiolucency of mandible as the first evidence of multiple myeloma: A clinico-radiographic case report

    Directory of Open Access Journals (Sweden)

    Ravi Prakash Sasankoti Mohan

    2014-01-01

    Full Text Available The incidence of multiple myeloma (MM affecting the jaws is 30% and on rare occasions the oral involvement can be the first indication of the disease. Authors report a case of MM in a 40-year-old woman who presented with a multilocular radiolucent lesion in the left mandible initially mistaken as an ameloblastoma. Conventional radiographs revealed a multilocular lesion on the molar region. Computed tomography (CT and 3 dimensional CT revealed lytic, space occupying lesion perforating the inferior cortex. Magnetic resonance imaging (MRI revealed a hypointense lesion on T1 weighted image and hyperintense lesion on T2 weighted image. Histopathological and lab investigations lead to the diagnosis of MM. MRI is superior in depicting the size of the lesion as compared to CT and conventional radiographs.

  3. A multilocular radiolucency of mandible as the first evidence of multiple myeloma: A clinico-radiographic case report.

    Science.gov (United States)

    Mohan, Ravi Prakash Sasankoti; Gill, Navneet; Verma, Sankalp; Chawa, Venkateshwar Rao; Tyagi, Kuber; Agarwal, Neha

    2014-03-01

    The incidence of multiple myeloma (MM) affecting the jaws is 30% and on rare occasions the oral involvement can be the first indication of the disease. Authors report a case of MM in a 40-year-old woman who presented with a multilocular radiolucent lesion in the left mandible initially mistaken as an ameloblastoma. Conventional radiographs revealed a multilocular lesion on the molar region. Computed tomography (CT) and 3 dimensional CT revealed lytic, space occupying lesion perforating the inferior cortex. Magnetic resonance imaging (MRI) revealed a hypointense lesion on T1 weighted image and hyperintense lesion on T2 weighted image. Histopathological and lab investigations lead to the diagnosis of MM. MRI is superior in depicting the size of the lesion as compared to CT and conventional radiographs.

  4. Melanotic neuroectodermal tumor of infancy. MR findings and a review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, G.O. Jr.; Davis, P.C.; Patrick, L.E.; Winn, K.J.; Ball, T.I.; Wyly, J.B. (Emory Univ., Atlanta, GA (USA). Dept. of Radiology)

    1989-11-01

    Melanotic neuroectodermal tumor of infancy is an uncommon neoplasm occurring primarily in the child one year or less in age. Difficulty in deciding the cellular origin of this tumor has led to numerous names, including congenital melanocarcinoma, melanotic epithelial odontoma, melanotic ameloblastoma, and retinal anlage tumor, to list a few. Electron microscopy and histochemical studies, however, have now established the neural crest the most likely origin. The most frequent site of occurrence is the maxilla followed by the skull, the brain and the mandible. The genital organs are the most frequent extracranial site. Within the skull, there is a predilection for the anterior fontanel. The following is a case report of a young child with melanotic neuroectodermal tumor of infancy arising at the anterior fontanel. Included is a discussion of magnetic resonance (MR) findings, which to our knowledge, have not been previously reported in this tumor. (orig.).

  5. Odontoameloblastoma: A case report

    Directory of Open Access Journals (Sweden)

    Amita Negi

    2015-01-01

    Full Text Available Odontoameloblastoma (OA is an extremely rare odontogenic tumor that contains an ameloblastomatous component together with odontoma-like elements. Till date, very few cases have fulfilled the criteria of the current World Health Organization classification of odontogenic tumors. It is characterized by slow, progressively growing lesion with growth pattern similar to solid multi-cystic ameloblastoma. The majority of the tumors are associated with unerupted teeth and commonly seen in males. It is usually asymptomatic and may occur in either maxilla or mandible, but shows a slight predilection for mandible. As this tumor is extremely rare, there exists controversy regarding its treatment. Here, we present a case of OA in 17-year-old female patient resembling a fibro-osseous lesion and a brief review of the related literature.

  6. Bilateral Calcifying Cystic Odontogenic Tumour of Mandible: A Rare Case Report and Review of Literature

    Science.gov (United States)

    Khandelwal, Pragun; Mhapuskar, Amit

    2015-01-01

    Calcifying cystic odontogenic tumour (CCOT) is a relatively rare lesion of oral and maxillofacial region and forms only 2% of all odontogenic tumours. It was previously known as Calcifying odontogenic cyst and only recently has been classified as a tumour by WHO. The controversy regarding its origin can be owed to its diverse clinical and histopathological presentation and variation in reported malignant potential. It was first reported by Gorlin in 1962 and since then conundrum regarding its true nature has persisted. It is seen in association with other lesions like odontoma, ameloblastoma and ameloblastic fibroma. Both intra-osseous and extra-osseous forms of CCOT have been reported. It commnoly occurs in anterior region with equal preponderance in maxilla and mandible. Here we present a rare case of bilateral CCOT in the posterior mandible of a 16-year-old male patient which was discovered incidentally during a radiographic examination. PMID:26673837

  7. Differential diagnosis of tumors of the mandible and maxilla: radiological aspects; Diagnostico diferencial dos tumores da manbibula e maxila

    Energy Technology Data Exchange (ETDEWEB)

    Isberner, Rony Klaus; Nagazava, Marcio M.; Chiang, Jeng Tyng; Goncalves, Marcelo [Hospital do Cancer de Sao Paulo, SP (Brazil). Dept. de Imagem; Dib, Luciano L. [Hospital do cancer de Sao Paulo, SP (Brazil). Dept. de Estomatologia

    1999-06-01

    The radiolucent lesions of the maxilla and jaw can present similar features, such as location, proximity or dental inclusion, insufflative character and density. They are so alike that those signs frequently are not enough for the diagnosis. Among those lesions, we present follicular cysts, ameloblastomas, odontogenic keratocysts, central giant cell lesion, neurofibroma, mucoepydermoid carcinoma and hemangioma, examined with panoramic X-rays, computed tomography and in a specific case, a SPECT for the jaw, with red blood cells-{sup 99m} Tc. The objective of this work is to demonstrate in a illustrative way, the radiographic features of some of the radiolucent lesions of the maxilla and jaw, whose differential diagnosis becomes sometimes very difficult, but can be achieved through signs that are more compatible with certain lesions. (author)

  8. Translational cancer vaccine: from mouse to human to cat

    Science.gov (United States)

    Levenson, Richard

    2015-03-01

    Acanthomatous ameloblastoma is a locally invasive tumor arising in the gingiva that can progress rapidly, invade and destroy bone. If the lesion involves the upper jaw, surgical excision may not be possible and while local control is imperative, other therapies have not been fully evaluated. The primary author's personal cat, Gabriella, developed this tumor, with gingival masses around teeth in the upper jaw and evidence of widespread bony destruction of the hard palate. Because of his involvement with Immunophotonics Inc. as an advisor, the author was aware of an in situ autologous cancer vaccine (inCVAX) that is currently under development by the company. One session was performed in a veterinary clinic in Arkansas, and two follow-up sessions at the small animal hospital at the UC Davis veterinary school. No other therapy was provided. As of this writing, 3+ years after first treatment and 3 years, 4 months after presentation, Gabriella is well, with no evidence of disease.

  9. Two cases report of Calcifying Odontogenic Cyst

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do; Lee, Wan; Paeng, Jun Young; Lee, Jun; Choi, Moon Ki [School of Dentistry, Wonkwang University, Wonkwang Dental Research Institute, Jeonju (Korea, Republic of); Son, Hyun Jin [Department of Pathology, School of Medicine, Eulji University, Daejeon (Korea, Republic of)

    2009-09-15

    The calcifying odontogenic cyst (COC) is a rare disorder of the jaws and shows various radiographic features. The purpose of this study is to describe the different radiographic appearances of 2 cases of COC. Case 1 was located in the posterior maxilla extending into maxillary sinus, showing unilocular radiolucency with a well-defined margin. Cortical bone expansion and thinning were prominent. Root resorption of adjacent teeth was apparent. Case 2 showed unilocular radiolucency with a calcified material. Calcification was supposed to be dystrophic dental hard structures, detected at the periphery of the lesion. Ghost cell and proliferation of ameloblastoma-like tissues were common features for these two lesions on histopathological findings. This reports presented common and atypical radiographic features of the COC.

  10. Incidental bony pathology when reporting trauma orthopantomograms

    Energy Technology Data Exchange (ETDEWEB)

    Macanovic, M., E-mail: mladenmaca@gmail.co [Derriford Hospital NHS Trust, Plymouth (United Kingdom); Gangidi, S.; Porter, G.; Brown, S.; Courtney, D. [Derriford Hospital NHS Trust, Plymouth (United Kingdom); Porter, J. [Community Dental Service, Plymouth Primary Care Trust, Plymouth, Devon (United Kingdom)

    2010-10-15

    Radiologists frequently report orthopantomograms (OPTs) and other views of the mandible, most often in patients who have suffered facial trauma. These examinations may reveal incidental pathology. It is important that radiologists are aware of the radiological appearances and the clinical significance of these lesions. In this review we will present examples of the more common odontogenic lesions including: radicular cyst, odontogenic keratocyst, dentigerous cyst, ameloblastoma, and also examples of non-odontogenic pathology: bisphosphonate-related osteonecrosis of the jaw (BRONJ) and chronic osteomyelitis. Although some of the lesions will require computed tomography (CT) or magnetic resonance imaging (MRI) for further lesion characterization and evaluation of the surrounding tissues, we are going to focus on the plain film appearances. We will also briefly discuss the pathogenesis, epidemiology, and treatment of these lesions.

  11. Odontoameloblastoma: A case report.

    Science.gov (United States)

    Negi, Amita; Puri, Abhiney; Nangia, Rajat; Sachdeva, Alisha

    2015-01-01

    Odontoameloblastoma (OA) is an extremely rare odontogenic tumor that contains an ameloblastomatous component together with odontoma-like elements. Till date, very few cases have fulfilled the criteria of the current World Health Organization classification of odontogenic tumors. It is characterized by slow, progressively growing lesion with growth pattern similar to solid multi-cystic ameloblastoma. The majority of the tumors are associated with unerupted teeth and commonly seen in males. It is usually asymptomatic and may occur in either maxilla or mandible, but shows a slight predilection for mandible. As this tumor is extremely rare, there exists controversy regarding its treatment. Here, we present a case of OA in 17-year-old female patient resembling a fibro-osseous lesion and a brief review of the related literature.

  12. Bilateral Calcifying Cystic Odontogenic Tumour of Mandible: A Rare Case Report and Review of Literature.

    Science.gov (United States)

    Khandelwal, Pragun; Aditya, Amita; Mhapuskar, Amit

    2015-11-01

    Calcifying cystic odontogenic tumour (CCOT) is a relatively rare lesion of oral and maxillofacial region and forms only 2% of all odontogenic tumours. It was previously known as Calcifying odontogenic cyst and only recently has been classified as a tumour by WHO. The controversy regarding its origin can be owed to its diverse clinical and histopathological presentation and variation in reported malignant potential. It was first reported by Gorlin in 1962 and since then conundrum regarding its true nature has persisted. It is seen in association with other lesions like odontoma, ameloblastoma and ameloblastic fibroma. Both intra-osseous and extra-osseous forms of CCOT have been reported. It commnoly occurs in anterior region with equal preponderance in maxilla and mandible. Here we present a rare case of bilateral CCOT in the posterior mandible of a 16-year-old male patient which was discovered incidentally during a radiographic examination.

  13. Calcifying odontogenic cyst with ameloblastic fibroma: report of three cases.

    Science.gov (United States)

    Lin, Cheng-Chung; Chen, Chung-Ho; Lin, Li-Min; Chen, Yuk-Kwan; Wright, John M; Kessler, Harvey P; Cheng, Yi-Shing Lisa; Ellis, Edward

    2004-10-01

    Although it is a rare event, odontogenic tumors such as ameloblastoma, ameloblastic fibroma (AF), ameloblastic fibro-odontoma, and odontoma have been reported associated with calcifying odontogenic cyst (COC). There are only four cases of COC with AF cited in the English literature. However, three of these four cases were either included in a review of a series of cases or reported as an abstract, and limited clinical and histological information was provided. We present three additional cases of COC with AF and discuss the management for this combined lesion. Because COC is known for its histologic diversity and variable clinical behavior, and the clinical significance of an association of COC with AF is still unknown, we think it is valuable to report COC with AF with detailed clinical and pathological documentation.

  14. Clinical and Radiographic Study of Benign Odontogenic Tumors in the Jaws

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Gyung Yae; Park, Chang Seo [Dept. of Oral Radiology, College of Dentistry, Yonsei University, Seoul (Korea, Republic of)

    1989-11-15

    The author observed and analyzed the age, sex, chief complaint and radiographic finding of sixty-one cases of benign odontogenic tumors seen in Yonsei Medical Center, for the period of Jan. 1979 to Aug. 1989. The results were as follows: 1. Benign odontogenic tumors of 61 cases included 52 cases (85.3%) of ameloblastoma and odontoma, and 9 cases of other lesions. Radiographically, the border of the lesions were well-defined. 2. Ameloblastoma constituting twenty-seven cases (44.3%) occurred the average age of 31.1 years and had a 3:1 male predominance. The most common complaint was swelling (20 cases, 74.0%) and followed by pain (13 cases, 48.2%). Radiographically, the most common site was mandibular body area (74.0%) and the lesions were mainly multiocular radiolucency; in 17 cases (63.0%) and unilocular radiolucent lesion were seen in 10 cases (37.0%). 16 cases (59.3%) showed the resorption of roots of adjacent teeth. 3. Odontoma constituting twenty-five cases (41.0%) discovered at the average age of 16.9 years and had a 3:2 male predominance. The most common complaint was delayed eruption of tooth (8 cases, 31.0%) and 7 cases (27.0%) detected on a routine radiograph of the area. Radiographically, 17 cases (68.0%) were of compound type and 8 were of complex variety and compound odontomas were common in the anterior maxilla, whereas complex odontomas occurred more frequently in the posterior mandible. 19 cases (76.0%) showed the impaction of adjacent teeth.

  15. Fibroma ameloblástico versus quiste folicular hiperplásico Ameloblastic fibroma versus hyperplastic follicular cyst

    Directory of Open Access Journals (Sweden)

    J. Azúa-Romeo

    2004-06-01

    Full Text Available Resumen: El fibroma ameloblástico (FA es un tumor odontogénico mixto, compuesto por tejido mesenquimal y epitelio odontogénico, representando el 2% de los tumores odontogénicos, mientras que el quiste dentígero o folicular (QF, el segundo quiste odontogénico en frecuencia, está compuesto exclusivamente por tejido conjuntivo laxo (mesénquima, si bien, el saco fibroso puede contener restos de epitelio odontogénico incluidos, dando lugar a una imagen histológica muy similar. La importancia de esta diferenciación radica en el tratamiento, que es ligeramente más agresivo en el FA y en el comportamiento biológico, ya que el FA puede derivar en un sarcoma ameloblástico, y el QF puede evolucionar hacia ameloblastoma y más raramente carcinoma mucoepidermoide.Abstract: Ameloblastic fibroma (AF is a mixed odontogenic tumor composed of mesenchymal tissue and odontogenic epithelium, accounting for 2% of all odontogenic tumors, while dentigerous or follicular cyst (FQ, second odontogenic cyst in frequency, is formed exclusivelly by soft conective tissue (mesenchyme. Nevertheless, hiperplastic fibrous sac may contain rests of odontogenic epithelium, showing a similar histologic pattern. The importance of an adequate differentiation lies in the treatment, which is slightly aggresive for AF, and regarding the biological behaviour of both lesions, since AF might become in an ameloblastic sarcoma, while over an FQ could develope an ameloblastoma or even a mucoepidermoid carcinoma.

  16. Dental image source sex cyst%牙源性囊肿的影像表现

    Institute of Scientific and Technical Information of China (English)

    李时光

    2015-01-01

    目的 探讨牙源性囊肿的影像表现,对牙源性囊肿的影像表现的临床鉴别诊断价值.方法 选取我院2011~2014年收治的牙源性囊肿患者55例,并且对牙源性囊肿的影像进行回顾性分析,并与手术病理结果对比.结果 24例颌骨牙源性囊性病变中,牙源性角化囊肿6例,特点是单房囊性病变,囊内的密度呈不均匀状呈现;非角化囊肿14例,表现呈现为颌骨内出现囊肿,且边界清晰,密度均匀;造釉细胞瘤4例,表现为囊内密度分布不那么均匀,而且会对周围的组织造成侵害.结论 颌骨牙源性囊性的CT颌骨牙源性囊肿病症不同的CT呈现形式,效果比X线明显要好,是检测颌骨牙源性囊肿的重要依据.%ObjectiveDental image source sex cyst, images of tooth source sex cyst clinical value in differential diagnosis.methods In our hospital from 2011 to 2014, to select the independent of 55 patients with tooth source sex cyst, and images of tooth source sex cyst were retrospectively analyzed, and compared with surgical pathology results.Results 24 cases of jaw teeth source sex cystic lesion, the teeth of source sex keratocysts, 6 cases of these teeth source sex keratocysts features a single room with a cystic lesion, the density is uneven in the sac present; 14 cases of non keratocysts, not the performance of the keratin cysts appear to occur within a jaw cyst, and the boundary is clear, uniform density; Ameloblastoma 4 cases, the symptoms of ameloblastoma is experience less uniform density distribution inside the capsule, and will cause infringement to the surrounding tissue.Conclusion Jaw cystic CT jaw teeth tooth origin source sex cyst disease different CT presentation styles, it is better than X-ray effect, is the important basis of source sex cyst jaw teeth.

  17. A clinical study on osseous regeneration in the jaw defects using a composite of coral and bone marrow%珊瑚/骨髓复合人工骨修复颌骨缺损的临床应用研究

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    张森林; 孟昭业; 杨震; 董震; 寿柏泉

    2001-01-01

    Objectives:To evaluate the efficiency of packing jaw defects with a composite of coral and bone marrow. Methods:Twelve patients (9 with jaw cyst and 3 with ameloblastoma) underwent enucleation of jaw lesion and packing with a composite of coral and bone marrow.Repair of the bone defects was evaluated at 1 week,1,6 and 12 months postoperatively by clinical examination and X-ray films. Results:Wound healing after the operations on 10 patients was uneventful,and definite ossification around the implanted material could be detected at 1 month postoperatively.A lot of bone formation and partial resorption of coral were observed at 6 months postoperatively.Complete resorption of coral and complete bone repair were obtained at 12 months postoperatively.Wound breakdown was observed on two other patients,and the composite had to be removed completely. Conclusions:A composite of coral and bone marrow may enhances bone healing in jaw defects after cyst or ameloblastoma removal.%目的:评价珊瑚/骨髓复合人工骨修复颌骨缺损的疗效。方法:将珊瑚/骨髓复合人工骨用于充填9例颌骨囊肿和3例造釉细胞瘤术后遗留的骨腔,术后1周、1、6和12个月通过临床和X线检查以评价其骨修复效果。结果;10例伤口Ⅰ期愈合,术后1个月缺损区有新骨形成;6个月缺损区可见大量成熟的骨组织,部分珊瑚被降解吸收;12个月珊瑚完全被宿主骨取代,缺损区得到完全修复。另有2例因伤口裂开需去除珊瑚骨。结论:珊瑚/骨髓复合人工骨可促进颌骨缺损的修复,是较理想的骨移植替代材料。减少缝合时伤口的张力是植骨成功的关键。

  18. Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana – an eight year study

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    Ampofo Patrick

    2007-05-01

    Full Text Available Abstract Background The oro-facial region including the jawbones, the maxilla and mandible and related tissues can be the site of a multitude of neoplastic conditions. These tumours have a predilection for the entire facial region; however, odontogenic tumours tend to affect the mandible more than the maxilla, especially, in West African children. We report results from a retrospective study spanning eight years on the frequency, clinical presentation, sites and character of lower face tumours seen in the main referral hospital in Ghana. Patients and methods Records of consecutive patients of all age and sex seen by the first author's team at the Department of Oral and Maxillofacial Surgery, Korle-Bu Teaching Hospital with tumours affecting the lower part of the face from January 1996 to December 2003 were retrieved, coded and entered into a database. The data were then analyzed by age, sex, presenting signs and symptoms, site of lesion, and their histology. Results A total of 394 patients with oro-facial swellings were retrieved from the registry out of which 210 had lower face tumour and tumour-like lesions. The complete data set was obtained for 171 patients, comprising 99 (58% males and 72 (42% females. The most common clinical presenting features were mandibular facial swelling (63%, intra-oral swelling (55%, pain (41% and ulceration (29%. The tumours were predominantly found in the right (43%, anterior (19% and left (18% aspects of the lower face. The remainder making up 20% were found in the floor of the mouth, tongue and lips. Seventy eight (45.6% of the patients presented with lesions that were classified as malignant of which 54 (62% were diagnosed as squamous cell carcinoma (SCC. Sixty-two (36.3% had benign odontogenic tumours and thirty-one (18.1% had non-odontogenic tumour-like lesions. Fifty-four (62% of malignant tumours were squamous cell carcinoma; 58 (93.6% of the benign odontogenic tumours were classified as ameloblastoma. The

  19. Giant aneurysmal bone cyst of the mandible with unusual presentation.

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    Capote-Moreno, Ana; Acero, Julio; García-Recuero, Ignacio; Ruiz, Julián; Serrano, Rosario; de Paz, Víctor

    2009-03-01

    Aneurysmal bone cysts are rare benign lesions of bone tissue, infrequent in craneofacial skeleton with regard to other structures like long bones or the spine. They are composed of sinusoidal and vascular spaces blood-filled and surrounded by fibrous tissue septa. We present a case of a 29-year-old Caucasian male with a big swelling in the left mandible associated to pain and rapid growth. He referred previous extraction of the left inferior third molar. On the X-ray study, an expansive multilocular and high vascularized bony lesion within the mandibular angle was observed. It produced expansion and destruction of lingual and buccal cortex. An incisional biopsy was performed showing a fibrous tissue with blood-filled spaces lesion suggestive of an aneurysmal bone cyst. After selective embolization of the tumour, surgical resection was done with curettage and immediate reconstruction of the defect with an anterior iliac crest graft. Aneurysmal bone cysts are non-neoplastic but locally aggressive tumours with occasional rapid growth that may be differentiated from other multilocular process like ameloblastoma, ossifying fibroma, epithelial cyst, giant cell granuloma and sarcomas. Treatment of choice consists on conservative surgical excision of the mass with curettage or enucleation. When resection creates a big defect, primary surgical reconstruction is recommended.

  20. Odontogenic Tumors: A 13-year Retrospective Study of 395 Cases in a South Indian Teaching Institute of Kerala

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    Deepak Pandiar

    2015-07-01

    Full Text Available Objective: T he aim o f the present study was to determine the epidemiology and clinicopathological presentation of odonto­ genic tumors (OTs seen in a Government Teaching Institute from Kozhikode district of Kerala (South India, over a period of 13 years and to compare the data obtained with previous reports published in literature from different world population. Study design: Records of the Oral Pathology and Microbio logy, Government Dental College, Kozhikode (Kerala, South India, were analyzed during a period of 13 years and reclassified accor- ding to World Health Organization (WHO 2005 Classification. Results: A total of 6.08% of odontogenic tumors were reported out of which (96.7% were benign and (3.3% were malignant. Keratocystic odontogenic tumor (35.9% was the most frequent type, followed by ameloblastoma (25.9%, calcifying cystic odonto genic tumor (10.6% , and odontoma (8.9%. The mean age was 32.69 ± 17.2 7, and males were more commonly affected. Conclusion: A marked geographic and demographic variation was observed in the relative frequency of various odontogenic tumors in the South Indian population which stresses upon the influence of genetic and/or environmental (epigenetic factors on tumor pathogenesis.

  1. A study on the mixed jaw lesions associated with teeth

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    Nah, Kyung Soo [Dept. of Dental Radiology, College of Dentistry, Pusan National University, Pusan (Korea, Republic of)

    2000-03-15

    1. Retrospectively evaluate the accuracy of tentative diagnosis or impression from the clinico-radiographic materials of jaw lesions which showed mixed lesions associated with teeth. 2. To observe the diagnostic importance of the calcified part of the lesions which appear as radiopaque areas. 14 cases of jaw lesions which showed mixed lesions associated with teeth were reviewed. These lesions were mostly diagnosed as adenomatoid odontogenic tumors (6 cases) or calcifying odontogenic cysts with (4 cases) or without odontomas (4 cases). The calcified elements of the lesions which demonstrated various sizes and patterns of radiopaque shadows resembled odontoid tissues in some cases but could not be defined in some other cases radiographically. The final histopathologic diagnosis confirmed adenomatoid odontogenic tumors in 4 of the 6 cases. The remaining 2 cases turned out to be odontoma and ameloblastic fibroodontoma. The 4 cases of calcifying odontogenic cysts with odontomas were correct in 3 cases but remaining 1 case was just odontoma. The 4 cases of calcifying odontogenic cysts were proved to be odontogenic keratocyst, calcified peripheral fibroma, unicystic ameloblastoma and squamous cell carcinoma. The diagnostic accuracy of the adenomatoid odontogenic tumors and calcifying odontogenic cysts were high when the lesions show typical appearance. The calcifications which show radiopaque areas could be odontomas or dystrophic calficifations or remnants of bone fragments from resorption.

  2. Odontogenic tumors: A review of 675 cases in Eastern Libya

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    Saravana HL Goteti

    2016-01-01

    Full Text Available Aims: The aim of this study was to determine the relative frequency of odontogenic tumors (OTs in an Eastern Libyan population based on the 2005 World Health Organization (WHO classification, and also to compare the actual data with previous studies. Materials and Methods: We retrieved and analyzed 85 OTs from a total of 675 tumors and tumor-like lesions of the oral and perioral structures, for gender, age, tumor site, and frequency. The diagnosis was based on the most recent WHO (2005 classification of OTs. Results: OTs constituted 12.6% of all oral/jaw tumors and tumor-like lesions. Ameloblastoma (28.2% was the most common type, followed by keratocystic odontogenic tumor (25.2% and odontoma (19.9%. The male: female ratio was 1.2:1, and maxilla: mandible ratio 1:2. The mean age of occurrence of tumors was 29 years with a peak incidence between 10 and 40 years. Conclusions: OTs are relatively common lesion in this Libyan Population, but the incidence of tumors is neither similar to Caucasians nor Sub-Saharan population.

  3. Prevalence of odontogenic cysts and tumors among UAE population

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    Natheer Hashim Al-Rawi

    2013-01-01

    Full Text Available Background: Odontogenic cysts and tumors are lesions that tend to arise from the tooth apparatus or its remnants. Odontogenic cysts and tumors constitute an important aspect of oral maxillofacial pathology as they can be diagnosed in general dental practice. Aim: The purpose of this study was to evaluate the prevalence of odontogenic cysts and tumors diagnosed in the UAE and to compare the results with findings in the literature. Materials and Methods: Data of odontogenic cysts diagnosed between 1990 and 2010 were collected from the files of the Oral Pathology Laboratory and Oral Surgery Department of Tawam Hospital, UAE. Results: Most of the prevalent odontogenic cysts are radicular cysts (69.1% - followed by dentigerous cysts (7.9%. Among the odontogenic tumors, the most prevalent is odontoma (12.2% followed by ameloblastoma (2.9%. The middle and posterior mandible was the most common anatomic site for the formation of cysts and tumors. In fact, 93.4% of patients over 40 years presented with odontogenic cysts, whereas 6.3% presented with odontogenic tumor. Odontoma as odontogenic tumor was seen mostly in the first and second decades of life. Conclusion: The prevalence of odontogenic cysts was similar to that reported in the literature, with inflammatory cysts occurring most frequently.

  4. Tindakan ‘Surgical Exposure’ pada Impaksi Gigi Insisif Satu Atas (Laporan Kasus

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    Sarworini B Budiardjo

    2015-11-01

    Full Text Available Gigi impaksi adalah gigi yang tertahan di dalam tulang rahang, secara klinis dapat dijumpai sebagai gigi yang lambat erupsi, gigi yang tertutup kembali oleh jaringan selama proses erupsi, atau proses erupsi yang berhenti. Penyebab terjadinya impaksi sebagai akibat gangguan patologik seperti ameloblastoma, ameloblastic fibrousodontoma, atau kista dentigerous dan gangguan non patologik berupa penebalan jaringan ikat akibat pencabutan gigi terlalu awal. Impaksi gigi insisif satu tetap atas sering dihubungkan dengan terjadinya odontoma, gigi supernumerary, pasien cleiocranial dysostosis, dan traumatic injuries. Perawatan gigi impaksi sesuai dengan penyebab; bila disebabkan faktor patologik, maka pengambilan seluruh gigi menjadi pilihan perawatan. Pada gigi impaksi akibat faktor non patologik, maka dilakukan tindakan bedah dengan tujuan membuka jalan erupsi (surgical exposure. Setelah surgical exposure dapat dilakukan pemasangan mahkota dari seluloid atau alumunium shell yang disemenkan pada mahkota gigi. Pada laporan kasus ini anak wanita usia 10 tahun dengan gigi insisif satu tetap atas kiri yang mengalami impaksi di bagian palatal dan untuk membantu erupsi dilakukan tindakan bedah disertai pemasangan mahkota seluloid. Tindakan tersebut dilakukan setelah mengalami kegagalan pada pembedahan pertama dengan terjadinya pertautan jaringan lunak, sehingga gigi tetap mengalami kesulitan erupsi. Hasil perawatan kedua menunjukkan keberhasilan, setelah 10 bulan perawatan gigi insisif satu tetap atas kiri erupsi lebih dari duapertiga mahkota.

  5. A 10-year retrospective study on odontogenic tumors in Iran

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    Nasim Taghavi

    2013-01-01

    Full Text Available Objective: The aim of this study was to review cases of odontogenic tumors diagnosed in two pathology centers in Tehran, Iran, during a 10-year period. Study Design: Patients′ records were seen at two teaching pathology Centre′s of Shahid Beheshti University between the months of March 2000 to 2010 with histologic diagnosis of any type of odontogenic tumors. The records were analyzed for frequency, age, sex, site, as well as clinical, radiographic and histopathologic findings. Results: Of 30706 biopsies, 4767 (15.5% cases were diagnosed as oral and maxillofacial lesions. Among these, 720 cases were tumoral with 188 (26.1% cases of odontogenic tumors. Tumors with odontogenic epithelium origin formed 70.2% of total numbers of odontogenic tumors. Mixed odontogenic tumors and tumors of odontogenic ectomesenchyme comprised 12.2% and 17.5% of the cases respectively. Ameloblastoma, with a frequency of 62.2% was the most common tumor in this review which was followed by odontoma and odontogenic myxoma. Conclusion: Although there are few studies on odontogenic tumors in literature, the comparison of our results with existing data shows significant differences in the distribution of tumors and age of patients, which may be due to ethnic features and geographic distribution of patients. Future studies on other ethnic groups are essential for further clarification of the findings in this research.

  6. Radiological and histopathological study of benign tumors of the mandible

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    Yoo, Seon Young; Baek, Seung Yon; Choi, Kyung Hee; Suh, Jeung Soo; Rhee, Chung Sik; Kim, Hee Seup [Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    1984-06-15

    Benign tumors of the mandible are uncommon lesions. That were classified into odontogenic tumors and nonodontogenic tumors. Author reviewed the radiological evaluation and pathological microscopic finding from 33 benign tumors of the mandible that were confirmed by the biopsy during last 10 years in Dental Clinics, Ewha Womans University Hospital and Seoul National University Dental Hospital. Following results were obtained; 1. Benign tumors of the mandible were classified into odontogenic (66.7%) and non-odontogenic tumors (33.3%). 2. The range of the age distribution was between 6 years and 67 years old. The commonest age group was the second decade (39.4%). 3. There was no difference to sex distribution. 4. The most frequent location was the body of the mandible (42.4%). 5. Radiographic findings were relatively characteristic in odontogenic tumors rather than non-odontogenic tumors. 1) Radiolucent cystic lesions-ameloblastoma, odontogenic myxoma, odontogenic fibtoma, aneurysmal bone cyst and neurofibroma. 2) Radiopaque mass lesions-odontoma, cementoma and osteoma. 3) Mixed patterns-ossifying fibroma, cementifying fibroma, calcifying odontogenic epithelial tumor and hemangioma. It was concluded that the radiographic examination was of value to diagnose the benign tumors of the mandible in symptomless patients.

  7. Odontogenic Tumors: A Review of 675 Cases in Eastern Libya

    Science.gov (United States)

    Goteti, Saravana HL

    2016-01-01

    Aims: The aim of this study was to determine the relative frequency of odontogenic tumors (OTs) in an Eastern Libyan population based on the 2005 World Health Organization (WHO) classification, and also to compare the actual data with previous studies. Materials and Methods: We retrieved and analyzed 85 OTs from a total of 675 tumors and tumor-like lesions of the oral and perioral structures, for gender, age, tumor site, and frequency. The diagnosis was based on the most recent WHO (2005) classification of OTs. Results: OTs constituted 12.6% of all oral/jaw tumors and tumor-like lesions. Ameloblastoma (28.2%) was the most common type, followed by keratocystic odontogenic tumor (25.2%) and odontoma (19.9%). The male: female ratio was 1.2:1, and maxilla: mandible ratio 1:2. The mean age of occurrence of tumors was 29 years with a peak incidence between 10 and 40 years. Conclusions: OTs are relatively common lesion in this Libyan Population, but the incidence of tumors is neither similar to Caucasians nor Sub-Saharan population. PMID:27013857

  8. Digital image processing of mandibular trabeculae on radiographs

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    Ogino, Toshi

    1987-06-01

    The present study was aimed to reveal the texture patterns of the radiographs of the mandibular trabeculae by digital image processing. The 32 cases of normal subjects and the 13 cases of patients with mandibular diseases of ameloblastoma, primordial cysts, squamous cell carcinoma and odontoma were analyzed by their intra-oral radiographs in the right premolar regions. The radiograms were digitized by the use of a drum scanner densitometry method. The input radiographic images were processed by a histogram equalization method. The result are as follows : First, the histogram equalization method enhances the image contrast of the textures. Second, the output images of the textures for normal mandible-trabeculae radiograms are of network pattern in nature. Third, the output images for the patients are characterized by the non-network pattern and replaced by the patterns of the fabric texture, intertwined plants (karakusa-pattern), scattered small masses and amorphous texture. Thus, these results indicates that the present digital image system is expected to be useful for revealing the texture patterns of the radiographs and in the future for the texture analysis of the clinical radiographs to obtain quantitative diagnostic findings.

  9. A retrospective study of 377 biopsies with a provisional

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    Taxiarchis G. KONTOGIANNIS

    2014-08-01

    Full Text Available Residual cysts (RC are radicular cysts left behind after tooth extraction. Many jaw lesions of non-odontogenic inflammatory origin may mimic the residual cyst. Aim: Τo record and discuss the prevalence and the features of jaw lesions mimicking RC, from the specimen with a provisional diagnosis of RC submitted for pathologic examination. Materials & Methods: The biopsy request forms of all lesions submitted for pathologic examination with the clinical diagnosis of RC, during a 14-year period, and the respective final pathology reports, were retrospectively studied. Selected clinical features were recorded. Results: 377 cases were retrieved. In 42 of them (11.1% the pathologic diagnosis was of a non-inflammatory odontogenic lesion. The most commonly misdiagnosed lesion was the odontogenic keratocyst (45.26%, while one ameloblastoma and 2 malignancies (metastatic tumor and malignant spindle cell tumor were also found. Conclusions: A lesion clinically diagnosed as a RC stands 1 out of 10 possibilities to be a non-odontogenic inflammatory lesion including malignant neoplasms. Thus, all lesions with clinical and radiographic features consistent with a RC must be enucleated and examined.

  10. Mandibular reconstruction using stereolithographic 3-dimensional printing modeling technology.

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    Cohen, Adir; Laviv, Amir; Berman, Phillip; Nashef, Rizan; Abu-Tair, Jawad

    2009-11-01

    Mandibular reconstruction can be challenging for the surgeon wishing to restore its unique geometry. Reconstruction can be achieved with titanium bone plates followed by autogenous bone grafting. Incorporation of the bone graft into the mandible provides continuity and strength required for proper esthetics and function and permitting dental implant rehabilitation at a later stage. Precious time in the operating room is invested in plate contouring to reconstruct the mandible. Rapid prototyping technologies can construct physical models from computer-aided design via 3-dimensional (3D) printers. A prefabricated 3D model is achieved, which assists in accurate contouring of plates and/or planning of bone graft harvest geometry before surgery. The 2 most commonly used rapid prototyping technologies are stereolithography and 3D printing (3DP). Three-dimensional printing is advantageous to stereolithography for better accuracy, quicker printing time, and lower cost. We present 3 clinical cases based on 3DP modeling technology. Models were fabricated before the resection of mandibular ameloblastoma and were used to prepare bridging plates before the first stage of reconstruction. In 1 case, another model was fabricated and used as a template for iliac crest bone graft in the second stage of reconstruction. The 3DP technology provided a precise, fast, and cheap mandibular reconstruction, which aids in shortened operation time (and therefore decreased exposure time to general anesthesia, decreased blood loss, and shorter wound exposure time) and easier surgical procedure.

  11. Histopathologic changes in soft tissue associated with radiographically normal impacted third molars

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    Kotrashetti Vijayalakshmi

    2010-01-01

    Full Text Available Background: The incidence of impacted or embedded third molars accounts for approximately 98%. Since 1948, there are studies reporting pathological changes in an asymptomatic dental follicle. Controversy still exists for removal of asmptomatic impacted teeth. Hence, this study was performed to histologically evaluate soft tissue pathosis in the pericoronal tissues of impacted third molars with pericoronal radiolucency measuring up to 2.5 mm on orthopantomographs. Materials and Methods: Forty-one asymptomatic impacted third molars with follicular space of up to 2.5 mm on radiographs were included. The disimpacted teeth and the follicular tissues were obtained for histological examination. Results: Age of the patients ranged from 14 to 25 years. Of 41 tissues evaluated, histopathological reports of 18 follicles were suggestive of dentigerous cyst, two follicles showed odontogenic keratocyst, one follicle each of calcifying epithelial odontogenic cyst, ameloblastoma-like proliferation, odontogenic myxoma and odontogenic fibroma. Conclusion: This study showed 58.5% of asymptomatic cases with definite pathological changes. Hence, thorough clinical and radiographic examination should be carried out for all impacted third molars and the dental follicular tissue should be submitted for histopathological evaluation.

  12. Oral and maxillofacial tumours in children: a review.

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    Sato, M; Tanaka, N; Sato, T; Amagasa, T

    1997-04-01

    This retrospective review presents our experience of oral and maxillofacial tumours in children. The subjects were 250 children under the age of 15 years (out of a total of 2747 patients with oral and maxillofacial tumours), who were treated after histopathological confirmation of their diagnoses during the 28 years 1965-92. Diagnosis, incidence, and age at presentation were the main outcome measures and the results showed that 232 patients (93%) had benign tumours and 18 (7%) were malignant. The most common benign tumour was haemangioma (n = 69) and the most common malignant tumour sarcoma (n = 14). The most common odontogenic tumour was odontoma (n = 47) and non-odontogenic tumour ossifying fibroma (n = 5). The most common site of soft tissue tumours was the tongue (n = 65) and of bony tumours the mandible (n = 62). About a third of the tumours developed in patients between the ages of 6 and 11 years. Most of the angiomas developed in patients less than 6 years old, and most of the ameloblastomas in those over 12 years of age. Children accounted for 55% of patients with lymphangoma, 41% of those with odontoma, and 22% of those with haemangioma. It is concluded that most of these lesions were probably developmental malformations rather than neoplasms, and that the definition of oral and maxillofacial tumours in children should be reconsidered.

  13. The relative frequency of odontogenic tumors: A study of 376 cases in a Brazilian population

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    Lima-Verde-Osterne, Rafael; Turatti, Eveline; Cordeiro-Teixeira, Renata

    2017-01-01

    Background Odontogenic tumors (OTs) are rare lesions, exclusive of the jaws, that are derived from epithelial and/or ectomesenchymal elements of the tooth-forming apparatus. Their biological behavior is heterogeneous, including hamartomatous tissue proliferation, benign nonaggressive and aggressive neoplasms, and malignant tumors with metastatic capacity. The aim of this study was to describe the relative frequency of odontogenic tumors in a Brazilian population. In addition, a review of the literature identified studies on odontogenic tumors that follow the 2005 World Health Organization. Material and Methods A total of 376 cases of odontogenic tumors from an oral pathology service were reviewed about age, gender, anatomic site and histologic diagnosis. Results Keratocystic odontogenic tumors (31.6%) were the most common, followed by ameloblastoma (28.5%), and odontoma (22.6%). The mean age was 32.2 years, and more than half the patients (52.1%) were in the second and third decades of life. The male to female ratio was 1:1.37, with a maxilla to mandible ratio of 1:2.08. Conclusions The variation in relative frequency of tumors observed among the several series, including the present study, is probably due in part to cultural differences between geographic areas but also to the study design. Key words:Pathology, epidemiology, odontogenic tumors. PMID:28160576

  14. Molecular markers of cancer in cartilaginous fish: immunocytochemical study of PCNA, p-53, myc and ras expression in neoplastic and hyperplastic tissues from free ranging blue sharks, Prionace glauca (L.).

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    Borucinska, J D; Schmidt, B; Tolisano, J; Woodward, D

    2008-02-01

    Archival formalin-fixed tissues from wild-caught adult blue sharks, Prionace glauca (L.), were used for immunocytochemical detection of proliferating cell nuclear antigen (PCNA), two oncoproteins from the oncogenes c-myc and pan-ras, and a protein product from the tumour suppressor gene p-53. All sharks were caught during summer months between 2000 and 2006 by recreational fishermen off the USA coast in the northwestern Atlantic. The sharks were necropsied on landing and selected organ samples were collected into elasmobranch formalin and processed for paraffin embedding and light microscopy. Paraffin-embedded sections from collected tissue were both stained with haematoxylin and eosin and processed by immunocytochemical techniques using antibodies raised against the PCNA, p-ras, c-myc and p-53 proteins. The lesions examined in this study included two well differentiated adenomatous gastric polyps, a testicular capsular mesothelioma, a gingival fibropapilloma with elements of ameloblastoma, three liver tumours, two pericardial fibropapillomas and six cases of proliferative serositis (pericarditis and peritonitis). Normal and hyperplastic tissues from blue sharks, and human neoplastic tissues served as negative and positive controls, respectively. We detected upregulation of PCNA in many neoplastic, one dysplastic and in some hyperplastic lesions, and positive p-ras and c-myc signals in some of the neoplastic lesions. None of the examined tissues showed positive p-53 signalling. This is the first literature report on immunocytochemical detection of molecular markers of cancer in sharks and in fish of the class Chondrichthyes.

  15. Clinical application of fenestration in jaw cyst%开窗术在颌骨囊肿治疗中的临床应用

    Institute of Scientific and Technical Information of China (English)

    马欣; 彭利伟

    2012-01-01

    目的 探讨应用开窗术治疗颌骨囊肿的临床实践.方法 应用开窗术治疗颌骨囊肿16例,其中含牙囊肿6例,牙源性角化囊肿7例,造釉细胞瘤2例,根尖囊肿1例.结果 16例颌骨囊肿均取得良好临床效果,无一例复发.结论 开窗术治疗颌骨囊肿符合功能、微创外科治疗原则,是一种行之有效的方法,值得推广.%Objective To study the clinical application of fenestration method in jaw cysts.Methods Fenestration were used in 16 eligible cases of jaw cysts,including 6 cases of dentigerous cysts,7 cases of odontogenic keratocysts,2 cases of ameloblastoma,and 1 case of radicular cyst.Results All cases were cured without recurrence.Conclusions Fenestration in jaw cysts is an effective method,which is according to function,and is surgical principles minimally invasive.

  16. Pleomorphic Adenoma of the Palate in a 10-year-old Child: A Case Report

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    SH Tabatabaei

    2016-03-01

    Full Text Available Salivary gland tumors  are  uncommon  within  children and  when  they do arise,  they  mainly  affect  the  major  salivary glands. Minor salivary gland  tumors  are  rare  in  children, which are  responsible for less than 10% of all the cases. Pleomorphic adenoma is the most common tumor of  the salivary glands in the all ages. A 10-year-old boy referred to the dentistry clinic with a swelling in the palate of adjacent unerupted right maxillary second molar. In sampling by curettage, clinical pathologist reported ameloblastoma. The patient was referred to the dental school of Shahid Sadoughi University of Medical Sciences for consultation. Second  microscopic analysis showed a benign pleomorphic adenoma that was confirmed by special staining periodic acid-Schiff (PAS, immunohistochemistry cytokeratin(CK, and S100 staining. Pleomorphic adenoma of minor salivary gland of children should be considered as a differential diagnosis of intraoral swelling in the palate.

  17. Fractura mandibular patológica por plasmocitoma intraóseo Pathological mandibular fracture due to intraosseous plasmacytoma

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    D. Antunes Freitas

    2012-06-01

    Full Text Available Los tumores de células plasmáticas se subclasifican en: Plasmocitomas solitarios de hueso, mieloma múltiple y plasmocitoma extramedular. El 80 % de estos últimos afecta la región de la cabeza y cuello surgiendo en el tejido blando del conducto respiratorio alto y, raras veces, en la cavidad bucal. La búsqueda de una enfermedad sistémica es importante es aquellos casos en los que se haga dicho diagnóstico. Se presenta el caso de un paciente, varón de 73 años de edad, residente en la localidad rural de Gran Mogol, en Minas Gerais (Brasil, La tomografía computarizada mostró hipodensidad y reabsorción osteolítica irregular en la base de la cresta alveolar mandibular izquierda. La lesión de medición 38,0×19,0×15,0 mm. En la TC se ve claramente la presencia de fractura patológica del lado izquierdo. La aspiración con aguja se realizó, donde se obtuvo sangre. Se realizó la biopsia incisional. El diagnóstico presuntivo fue ameloblastoma. La muestra de biopsia fue enviada para análisis anatomohistopatológica. La microscopía mostró células tumorales compuesto por células monomórficas, con núcleos ovalados, grandes periféricos, y excéntricos, nucléolos prominentes y citoplasma basófilo, rodeado por estroma escaso y la infiltración de hueso esponjoso. La prueba de orina se destinó específicamente a la proteína de Bence-Jones, que fue negativo. Las radiografías de cráneo y tórax fueron realizados y no mostró cambios. Luego completó un diagnóstico de Plasmocitoma solitario en la mandíbula. El paciente está sometido a radioterapia en el Servicio de Oncología de la Santa Casa de Misericordia. El paciente tuvo mucositis severa y cambios en el color facial como resultado de la radioterapia.Plasma cell tumors are subclassified into: Solitary plasmacytoma of bone, multiple myeloma and extramedullary plasmacytoma. 80% of the latter affects the region of the head and neck soft tissue arising in the upper respiratory

  18. Expressão de MMPs, marcadores angiogênicos e proliferação celular em tumores odontogênicos Expression of MMPs, angiogenic and proliferation cell markers in odontogenic tumors

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    Felipe Rodrigues de Matos

    2012-10-01

    Full Text Available INTRODUÇÃO E OBJETIVO: O conhecimento do comportamento biológico de lesões de natureza odontogênica é essencial para tornar a abordagem terapêutica adequada e estabelecer um prognóstico. A produção de metaloproteinases da matriz extracelular (MMPs, a angiogênese e a proliferação celular fornecem subsídios para o crescimento tumoral. O presente artigo tem como objetivo fazer uma revisão de literatura de pesquisas em tumores odontogênicos (TOs selecionados a partir da nova classificação da Organização Mundial da Saúde (OMS de 2005 sobre a expressão de MMPs, marcadores angiogênicos e proliferação celular e verificar, nestes estudos, a relação desses marcadores quanto ao comportamento biológico dessas lesões. RESULTADOS: Nota-se que as MMPs -1, -2, -7, -9 e -26 encontram-se mais expressas no componente epitelial e estroma e, particularmente, a -13 em estroma. Uma maior angiogênese é observada em TOs mais agressivos. CD 105 foi mais expresso no TO ceratocístico (TOC e CD34 em ameloblastomas sólidos (ASs. Relata-se elevada expressão do Ki-67 e p53 no TOC e no AS e baixo índice de proliferação celular no TO adenomatoide (TOA. CONCLUSÃO: Esses resultados mostram que as MMPs participam no processo de invasão e recorrência de algumas lesões odontogênicas, estando associadas ao comportamento biológico desses tumores. A angiogênese é fundamental para fornecer suporte à proliferação celular e esses dois eventos em conjunto estão correlacionados com diferentes níveis de comportamento biológico nos TOs, quando comparados com cistos de natureza odontogênica, o que pode sugerir o uso de inibidores angiogênicos como provável abordagem terapêutica nessas lesões.INTRODUCTION AND OBJECTIVE: The study of biological behavior of odontogenic lesions is essential to the establishment of appropriate therapeutic approach and prognosis. The production of extracellular matrix metalloproteinases (MMPs, angiogenesis and

  19. AVALIAÇÃO EPIDEMIOLÓGICA DE CÃES COM NEOPLASIAS ORAIS ATENDIDOS NO HOSPITAL DE CLÍNICAS VETERINÁRIAS DA UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL EPIDEMIOLOGICAL EVALUATION OF THE DOGS WITH ORAL TUMORS ATTENDED IN THE VETERINARY HOSPITAL OF FEDERAL UNIVERSITY OF RIO GRANDE DO SUL

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    Ruben Cavalcanti

    2009-09-01

    Full Text Available Os tumores orais em cães representam cerca de 6% de todas as neoplasias dessa espécie. O objetivo deste trabalho foi realizar um estudo epidemiológico dos cães com tumores orais atendidos no Hospital de Clínicas Veterinárias da Universidade Federal do Rio Grande do Sul durante o período de julho de 2003 a julho de 2007. Realizou-se a pesquisa nos arquivos do Laboratório de Histopatologia e nas fichas clínicas dos animais, para avaliação de dados como raça, sexo, idade e o tipo histológico dos tumores. Procedeu-se à análise de 79 cães, dentre os quais 39 (49,37% eram machos e 40 (50,63% eram fêmeas, com idades variando entre um e dezesseis anos (média de 7,7 anos. Os cães mais acometidos foram os sem raça definida, com dezesseis casos (19,76%, seguido pela raça Poodle, com doze casos (14,82%. As neoplasias malignas representaram 50,63% dos casos e as benignas 49,37%%. Os tumores mais comumente encontrados foram o melanoma e o épulis acantomatoso, com dezenove casos cada (23,46%, seguidos pelo fibrossarcoma e o épulis fibromatoso, com nove casos cada (11,11%, plasmocitoma com oito casos (9,88%, ameloblastoma com quatro casos (4,94%, carcinoma epidermoide e osteossarcoma com três casos cada (3,7%. Por meio deste estudo, verificou-se que os tumores malignos apresentam uma maior incidência, e os tipos histológicos mais frequentes foram o melanoma, o fibrossarcoma, o épulis acantomatoso e fibromatoso.
     
    PALAVRAS-CHAVES: Câncer, cães, tumores orais. Oral tumors reach about 6% of all the neoplasm in dogs. The objective of this research was to form an epidemiological study on dogs with oral tumors that have been treated at the Veterinary Hospital of Federal University of rio Grande do Sul from July 2003 to July 2007. The research was conducted within the archives of the histopathology laboratory, using the animals’ clinical files, in which they had been categorized by breed, sex, age and the tumors

  20. Stafne kemik kavitesi: 3 olgu sunumu

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    Secil Nigar Karadeniz

    2012-01-01

    Full Text Available

    Stafne bone cavities (SBC, which arise mandible angulus among third molar teeth, are round or ovoid-shaped, well-circumscribed, uniloküler and radiolucent lesions. Despite a wide age range seen, in men, 5. and 6. decades seen more. The differential diagnosis of traumatic bone cyst, ossifying fibroma, benign lesions such as florid osseous dysplasia and malignant lesions such as ameloblastoma done. Supporting imaging modalities such as sialography, computerised tomography (CT, magnetic resonance imaging (MRI should be used for differantial diagnosis. The aim of this case report was to higlight the use sialography and computered tomography (CT for detecting stafne bone cavity (SBC and to differenciate other radiographic appearance such as cystic lession in the jaws.

     

    ÖZET

    Stafne kemik kaviteleri (SKK, mandibula angulusu ile 3. molar dişler arasında izlenen  yuvarlak veya ovoid şekilli, iyi sınırlı, uniloküler ve radyolüsent görüntü veren lezyonlardır. Görülme yaşı çok geniş bir aralığa sahip olmasına rağmen, erkeklerde 5. ve 6. dekatlarda daha fazla görülmektedir. Ayırıcı tanısı travmatik kemik kisti, ossifiye fibroma ve florid osseoz displazi gibi bening lezyonların yanı sıra ameloblastoma gibi malign lezyonlarla yapılmaktadır. Ayırıcı tanıda sialografi, bilgisayarlı tomografi (BT veya magnetik rezonans görüntüleme (MRG gibi destekleyici görüntüleme yöntemlerinden yararlanılmalıdır. Bu olgu sunumunda, sialografi ve bilgisayarlı tomografi (BT  tekniğinin stafne kemik kavite (SKK görüntüsünün belirlenmesi ve çenelerde görülen diğer kistik görüntülerle ayırıcı tanıda kullanılmasının önemi değerlen-dirilmektedir.

  1. Tumor neuroectodérmico pigmentado infantil: Reporte de un caso Neuroectodermal tumor pigmented children: A case report

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    A.J. Díaz Caballero

    2011-08-01

    Full Text Available El tumor neuroectodérmico pigmentado es un tumor benigno de crecimiento rápido e intensamente pigmentado del maxilar inferior (y en ocasiones de otros sitios, que consiste en una masa infiltrativa de células dispuestas según un patrón alveolar. Aparece casi exclusivamente en lactantes. Se presenta como una tumoración protuberante en un maxilar o la mandíbula principalmente en tejidos blandos; encontrándose excepcionalmente en el tracto intestinal, pelvis, retroperitoneo y riñón. Clínicamente se manifiesta como una tumoración localizada, con presencia o no de zonas pigmentadas. Estas neoplasias son raras y afectan mayormente niños, que por lo general son menores de un año y que pueden ser congénitos. Su localización en cerca de un 70% es la mandíbula; facio-cervical, en 90%, también se reportaron en localizaciones como: fontanela anterior, hueso temporal y duramadre, epidídimo, huesos largos, mediastino. Éstos son considerados como formas periféricas, ya que existen formas centrales que pueden afectar cerebro, cerebelo, glándula pineal. La clínica de estos casos puede simular a muchas otras patologías, dificultando su diagnostico ya que es una masa que protruye y deforma que rara vez ulcera. Las radiografías muestran una masa radiolúcida con capacidad de destrucción focal y desplazamiento de los dientes, por lo que se puede confundir con un ameloblastoma es por esto que es necesario un manejo adecuado con los exámenes histológicos necesarios como se hizo en el presente caso.The Pigmented neuroectodermal tumor is a benign tumor of intensely pigmented and rapid growth of the lower jaw (and in occasions of other sites [places], that consists of a mass of infiltrative cells arranged according to an alveolar boss. It (he, she appears almost exclusively in nursing. He (she appears as a protruding tumor in the jaw Maxillary one or principally in the soft (smooth fabrics; being exceptionally in the intestinal tract, pelvis

  2. Primordial Odontogenic Cyst with Induction Phenomenon (Zonal Fibroblastic Hypercellularity) and Dentinoid Material Versus Archegonous Cystic Odontoma: You Choose!

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    Argyris, Prokopios P; Wetzel, Stephanie L; Pambuccian, Stefan E; Gopalakrishnan, Rajaram; Koutlas, Ioannis G

    2016-06-01

    The most recent A.F.I.P. fascicle defines primordial odontogenic cyst (POC) as a distinct, nonkeratinized, odontogenic cyst of "undetermined origin" forming in the place of a developing normal or supernumerary tooth. However, the majority of examples reported in the literature under this term represent odontogenic keratocysts (keratocystic odontogenic tumors). In addition, there are rare reported cases of cystic odontomas. An 18-year-old Caucasian male presented with a unilocular mandibular radiolucent lesion in the place of a congenitally missing molar. Histologically, it featured nonkeratinizing, thin stratified squamous epithelial lining with areas of spongiosis and foci of vacuolization of individual basal cells without significant nuclear palisading. Focally, budding of the basal cell layer was identified. A zone of increased cellularity featuring induction-type fibroblasts was present subepithelially as well as dentinoid deposits with odontogenic epithelial nests. Immunohistochemically, the epithelial lining was negative for calretinin and the induction-like zone negative for S100 protein, smooth muscle actin, and CD34. The case was externally reviewed by five oral pathologists who provided various diagnostic interpretations including primordial cyst, odontogenic cyst not otherwise specified (NOS), cyst with ameloblastic changes, and unicystic ameloblastoma. At that time, a final diagnosis of odontogenic cyst NOS was rendered with a comment that it may represent a true example of POC or a cystic odontoma. The lesion has not recurred within a 13 year follow-up period after initial excision. An unusual cystic lesion is presented that may represent a true example of POC with dentinoid formation or an archegonous cystic odontoma.

  3. Finite element analysis of customized reconstruction plates for mandibular continuity defect therapy.

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    Narra, Nathaniel; Valášek, Jiří; Hannula, Markus; Marcián, Petr; Sándor, George K; Hyttinen, Jari; Wolff, Jan

    2014-01-03

    Large mandibular continuity defects pose a significant challenge in oral maxillofacial surgery. One solution to this problem is to use computer-guided surgical planning and additive manufacturing technology to produce patient-specific reconstruction plates. However, when designing customized plates, it is important to assess potential biomechanical responses that may vary substantially depending on the size and geometry of the defect. The aim of this study was to assess the design of two customized plates using finite element method (FEM). These plates were designed for the reconstruction of the lower left mandibles of two ameloblastoma cases (patient 1/plate 1 and patient 2/plate 2) with large bone resections differing in both geometry and size. Simulations revealed maximum von Mises stresses of 63 MPa and 108 MPa in plates 1 and 2, and 65 MPa and 190 MPa in the fixation screws of patients 1 and 2. The equivalent strain induced in the bone at the screw-bone interface reached maximum values of 2739 micro-strain for patient 1 and 19,575 micro-strain for patient 2. The results demonstrate the influence of design on the stresses induced in the plate and screw bodies. Of particular note, however, are the differences in the induced strains. Unphysiologically high strains in bone adjacent to screws can cause micro-damage leading to bone resorption. This can adversely affect the anchoring capabilities of the screws. Thus, while custom plates offer optimal anatomical fit, attention should be paid to the expected physiological forces on the plates and the induced stresses and strains in the plate-screw-bone assembly.

  4. Indications and outcome of mandibular condylar and ramus surgeries

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    Babatunde O Akinbami

    2014-01-01

    Full Text Available Background: Different surgical procedures are utilized for treatment of various diseases of the posterior mandible depending on the type of disease, site, duration and age of the patient. A thorough knowledge of the anatomical relations of structures and adequate surgical skills are needed to minimize complications. The purpose of this study was to evaluate the indications and outcome of surgical techniques for diseases affecting the condyle and ramus of the mandibles. Patients and Methods: Data were retrieved from the case files of patients who had surgeries for diseases involving the ramus/condylar area of the mandible. The diagnosis/indications for surgery, procedure and postoperative outcomes were documented. Outcomes assessed were related to mouth opening, esthetics (appearance of scar and jaw symmetry and function (occlusion, Jaw movements. Complications such as nerve dysfunction were documented. Paresthesia was tested by simple tactile stimulations. Results: There were a total of 27 procedures done either on the condyle or ramus in 23 (100% patients between May 2006 and October, 2013. 16 procedures were done for tumors in 16 (69.6% patients, 14 (60.9% patients had Ameloblastoma, 1 (4.3% had central neurofibroma and one had keratocystic odontogenic tumor, two procedures for unilateral condylar fractures in 2 (8.6% patients, five procedures for ankylosis in 3 (13.0% patients and four procedures were done for dislocation in 2 (8.6% patients. There was no permanent nerve dysfunction; mouth opening, jaw movements and mastication were remarkably satisfactory. Conclusion: Esthetic and functional outcome were quite satisfactory when compared with the preoperative status.

  5. A retrospective investigation on canine papillomavirus 1 (CPV1 in oral oncogenesis reveals dogs are not a suitable animal model for high-risk HPV-induced oral cancer.

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    Ilaria Porcellato

    Full Text Available CPV1 (also called COPV is a papillomavirus responsible for oral papillomatosis in young dogs. The involvement of this viral type in oral oncogenesis has been hypothesized in oral squamous cell carcinomas (SCCs, but has never been investigated in other neoplastic and hyperplastic oral lesions of dogs. Aim of this study was to investigate the presence of CPV1 in different neoplastic and hyperplastic lesions in order to assess its role in canine oral oncogenesis; according to the results obtained, a second aim of the study was to define if the dog can be considered a valid animal model for oral high risk HPV-induced tumors. Eighty-eight formalin-fixed, paraffin-embedded (FFPE canine oral lesions including 78 oral tumors (papillomas, SCCs, melanomas, ameloblastomas, oral adenocarcinomas and 10 hyperplastic lesions (gingival hyperplasia were investigated with immunohistochemistry for the presence of papillomavirus L1 protein and with Real-Time PCR for CPV1 DNA. RT-PCR for RNA was performed on selected samples. All viral papillomas tested were positive for immunohistochemistry and Real-time PCR. In 3/33 (10% SCCs, viral DNA was demonstrated but no viral RNA could be found. No positivity was observed both with immunohistochemistry and Real-Time PCR in the other hyperplastic and neoplastic lesions of the oral cavity of dogs. Even though the finding of CPV1 DNA in few SCCs in face of a negative immunohistochemistry could support the hypothesis of an abortive infection in the development of these lesions, the absence of viral RNA points out that CPV1 more likely represents an innocent bystander in SCC oncogenesis. The study demonstrates a strong association between CPV1 and oral viral papillomas whereas viral contribution to the pathogenesis of other oral lesions seems unlikely. Moreover, it suggests that a canine model of CPV1 infection for HPV-induced oncogenesis could be inappropriate.

  6. [Studies on keratocystic odontogenic tumors].

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    Li, Tie-jun; Sun, Li-sha; Luo, Hai-yan; Yuan, Jun-wei; Gao, Li; Gu, Xiao-mei; Li, Xue-fen; Xu, Li-li

    2009-02-18

    Keratocystic odontogenic tumors (KCOTs, previously known as odontogenic keratocysts) are aggressive, noninflammatory jaw lesions with a putative high growth potential and a propensity for recurrence. This article puts together a summary of the serial studies related to KCOTs undertaken by the author's research group in recent years. Intraosseous jaw cysts with a solely orthokeratinized lining epithelium have been suggested to differ from the typical KCOTs. We report 20 cases of such cyst type under the term of 'orthokeratinized odontogenic cyst (OOC)'. Apart from the presence of a keratinizing epithelial lining, the OOC lacks the other histological features of KCOT, exhibits little if any tendency to recur, has no apparent association with NBCCS, may be cured by simple enucleation, and may thus constitute its own clinical entity. Mutations in PTCH1 gene are responsible for NBCCS and are related in tumors associated with this syndrome. We have so far detected 26 PTCH1 mutations (2 mutations occurred twice) in 10 out of 34 (29.4%) sporadic and 14 out of 16 (87.5%) NBCCS-associated KCOTs. The 26 mutations consisted of 10 frameshift, 2 nonsense, 3 aberrant splicing, 4 in-frame insertion/deletion/ duplication and 7 missense mutations. Two missense mutations in PTCH2 were also detected in 2 out of 15 NBCCS related KCOT patients. By contrast, no pathogenic mutation was detected in SMO. Thus, our data, together with reports from other groups, indicate that defects of PTCH1 are involved in the pathogenesis of syndromic as well as sporadic KCOTs. The pathogenic role of PTCH2 requires further investigation. A series of in vitro studies on bone resorption of KCOTs and ameloblastomas were undertaken by this group. The results indicate that odontogenic lesions could promote bone resorption in vitro and it is likely to be related to some of the cytokines secreted by the lesions.

  7. Head and neck reconstruction using infrahyoid myocutaneous flaps

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    Alfio José Tincani

    Full Text Available CONTEXT AND OBJECTIVE: The use of pedicled myocutaneous flaps in head and neck reconstruction is widely accepted. Here we describe our experience with infrahyoid flaps (IHFs employed to cover surgical defects in the oral cavity and oropharynx in patients with benign and malignant tumors. The aim was to evaluate the success rate for infrahyoid myocutaneous flap procedures performed at a single institution. DESIGN AND SETTING: Retrospective study, at the Head and Neck Surgery Service, Unicamp. METHODS: Fourteen IHFs were used to reconstruct surgical defects in eleven men (78.5% and three women (21.5% with a mean age of 66.4 years. The anterior floor of the mouth was reconstructed in nine patients (64.2%, the base of tongue in three (21.4%, the lateral floor in one (7.1%, and the retromolar area (7.1% in one. Thirteen patients (92.8% had squamous cell carcinoma (SCC and one (7.2% ameloblastoma. The disease stage was T3 in eight (61.5% of the SCC cases and T4 in five (38.5%. RESULTS: No patient presented total flap loss or fistula. The most common complication was epidermolysis, which delayed the beginning of oral ingestion. The patients with SCC received postoperative radiotherapy without major consequences to the flap. CONCLUSION: IHF is a safe and reliable procedure for reconstructing head and neck surgical defects. Due to its thinness and malleability, its use for oral cavity and oropharynx defects provides favorable cosmetic and functional outcomes. Complications, when present, are easy to manage.

  8. EXPRESSION AND SIGNIFICANCE OF bcl-2 FAMILY IN AMELOBLASTONA

    Institute of Scientific and Technical Information of China (English)

    WANG Jie; MA Jie; ZHONG Ming; LIU Jing-dong

    2006-01-01

    Objective: To study the expression of bcl-2 and bax in human ameloblastoma (AB), and investigate the role of apoptosis in genesis and development of AB and the relation of apoptosis with the clinic biological characteristics of AB. Methods:BCL-2 and BAX proteins were detected in 75 cases of AB (primary AB 31 cases, recurrent AB 37 cases, malignant AB 7cases) by S-P method. Oral normal mucosa (NOM) and Odontogenic kerotosyst (OKC) were used as controls. Bcl-2 and bax mRNA in 20 cases of AB, 12 cases of OKC were detected by in situ hybridization. Results: The positive ratio of BCL-2protein was 88.0% ( 66/75 ) in AB, 74.3% (26/35) in OKC and 44.4% (4/9) in NOM, respectively (P<0.001). BCL-2 protein was expressed in peripheral cells and a few scattered stellate-shape cells in AB. The positive ratio of BAX protein was 74.7%(56/75)in AB, 65.7%(23/35)in OKC and 77.8%(7/9) in NOM, respectively (P<0.001). BAX protein was expressed in peripheral cells and stellate-shape cells with similar intensity. BCL-2 expression increased in recurrent and AB canceration(P<0.01), while for BAX expression, the positive ratio was higher in recurrent AB, but lower than that of malignant AB. A moderate negative correlation between BCL-2 and BAX protein was found (rk=-0.331, P<0.001).Conclusion: AB has much more apoptosis-inhibiting protein than apoptosis- accelarating protein. Apoptosis plays an important role in genesis, development of AB. The fashion and intensity of bcl-2 and bax expression were different in various tissues and in benign or malignant AB.

  9. Kallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors

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    Crivelini, Marcelo Macedo; Oliveira, Denise Tostes; de Mesquita, Ricardo Alves; de Sousa, Suzana Cantanhede Orsini Machado; Loyola, Adriano Motta

    2016-01-01

    Context: Matrix metalloproteinase-20 (MMP20) (enamelysin) and kallikrein 4 (KLK4) are enzymes secreted by ameloblasts that play an important role in enamel matrix degradation during amelogenesis. However, studies have shown that neoplastic cells can produce such enzymes, which may affect the tumor infiltrative and metastatic behaviors. Aims: The aim of this study is to assess the biological role of MMP20 and KLK4 in odontogenic tumors. Materials and Methods: The enzymes were analyzed immunohistochemically in ameloblastoma, adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor, keratocystic odontogenic tumor with or without recurrence and odontogenic carcinoma. Statistical Analysis Used: Clinicopathological parameters were statistically correlated with protein expression using the Fisher's exact test. Kruskal–Wallis and Wilcoxon-independent methods were used to evaluate the differences in median values. Results: Positive Immunoexpression was detected in all benign lesions, with a prevalence of 75–100% immunolabeled cells. Patients were predominantly young, Caucasian, female, with slow-growing tumors located in the mandible causing asymptomatic swelling. No KLK4 expression was seen in carcinomas, and the amount of MMP20-positive cells varied between 20% and 80%. Rapid evolution, recurrence and age >60 years characterized the malignant nature of these lesions. Conclusions: Data showed that KLK4 and MMP20 enzymes may not be crucial to tumoral infiltrative capacity, especially in malignant tumors, considering the diversity and peculiarity of these lesions. The significant immunoexpression in benign lesions, remarkably in AOT, is likely associated with differentiated tumor cells that can produce and degrade enamel matrix-like substances. This would be expected since the histogenesis of odontogenic tumors commonly comes from epithelium that recently performed a secretory activity in tooth formation. PMID:27601817

  10. Success of dental implants in vascularised fibular osteoseptocutaneous flaps used as onlay grafts after marginal mandibulectomy.

    Science.gov (United States)

    Chang, Y-M; Pan, Y-H; Shen, Y-F; Chen, J-K; ALDeek, N F; Wei, F-C

    2016-12-01

    We have evaluated the survival of dental implants placed in vascularised fibular flap onlay grafts placed over marginal mandibulectomies and the effects on marginal bone loss of different types of soft tissue around implants under functional loading. From 2001-2009 we studied a total of 11 patients (1 woman and10 men), three of whom had had ameloblastoma and eight who had had squamous cell carcinomas resected. A total of 38 dental implants were placed either at the time of transfer of the vascularised fibular ostoseptocutaneous flaps (nine patients with 30 implants) or secondarily (two patients with eight implants). Four patients were given palatal mucosal grafts to replace intraoral skin flaps around the dental implants (n=13), and the other seven had the skin flaps around the dental implants thinned (n=25) at the second stage of implantation of the osteointegrated teeth. All vascularised fibular osteoseptocutaneous flaps were successfully transferred, and all implants survived a mean (range) of 73 (33-113) months after occlusal functional loading. The mean (SD) marginal bone loss was 0.5 (0.3) mm on both mesial and distal sides in patients who had palatal mucosal grafts, but 1.8 (1.6) mm, and 1.7 (1.5) mm, respectively, on the mesial and distal sides in the patients who had had thinning of their skin flaps. This difference is significant (p=0.008) with less resorption of bone in the group who had palatal mucosal grafts. Palatal mucosa around the implants helps to reduce resorption of bone after functional loading of implants.

  11. Clinical features and treatment of ameloblastic fibro-odontoma%成釉细胞纤维牙瘤的临床特点及治疗

    Institute of Scientific and Technical Information of China (English)

    徐峰; 王炳超; 孔丽; 王科; 贾暮云; 袁荣涛

    2016-01-01

    Ameloblastic fibro-odontoma ( AFO) is a rare odontogenic tumor. It often occurrs at the age under twenty, male more than in female. It is mostly located in the maxilla and mandible, and more common in the mandible. It grows slowly with no symptoms. There is asymptomatic swelling in the maxillofacial region and it delays tooth eruption in the case with AFO. X-ray examination always shows a cystic cavity in the jaw, with clear boundary. It is not easy to be differentiated from odontogenic tumors, such as ameloblas-toma and keratocystic odontogenic tumor. Pathological examination shows that neoplasm was composed of proliferating odontogenic epi-thelium in a cellular ectomesenchymal tissue, similar to ameloblastic fibroma in form. Hard tissue component is similar to odontoma, dental structures resembling dentine and enamel-like tissues. It has a low probability of malignancy. The most common treatment is sur-gical removal with low potential for recurrence. In this paper, one case with ameloblastic fibro-odontoma was reported and the clinical features and treatment of ameloblastic fibro-odontoma were investigated.%成釉细胞纤维牙瘤是一种少见的牙源性肿瘤,多发生于20岁以下,男性多于女性,上下颌骨均可发生,多发生于下颌骨,生长缓慢,无自觉症状,常表现为颌面部的肿胀、牙齿迟萌.X线片常见单房改变,表现为边界清楚的囊性透射影,不易与牙源性肿瘤鉴别.组织学表现,软组织成分为牙源性上皮和胚胎性的结缔组织,类似成釉细胞纤维瘤的形态,硬组织成分为牙本质、釉质样组织,类似牙瘤.恶变可能性低,治疗方式为手术摘除,一般不易复发.该文结合我科收治的成釉细胞纤维牙瘤病例,探讨成釉细胞纤维牙瘤的临床特点及治疗与预后.

  12. Prevalencia de tumores odontogénicos en el Hospital Base Valdivia: periodo 1989-2008

    Directory of Open Access Journals (Sweden)

    L.C. Thiers

    2013-12-01

    Full Text Available Objetivo: Este artículo corresponde a un estudio observacional de tipo descriptivo de corte transversal, tiene como objetivo determinar la prevalencia de tumores odontogénicos en la población atendida en el Hospital Base Valdivia, en un periodo de 20 años (1989-2008, según la nueva clasificación de lesiones tumorales de la WHO, 2005. Metodología: Se revisaron 2.078 informes de biopsias correspondientes a lesiones de la cavidad oral de los archivos de informes del servicio de Anatomía Patológica, Hospital Base Valdivia entre enero del año 1989 y diciembre del año 2008. Como criterios de inclusión están la presencia de un diagnóstico histopatológico en la ficha y legibilidad de ésta. Las variables a analizar incluyen: edad, género, diagnóstico histopatológico, tipo de tumor y área de localización. Los datos recolectados fueron tabulados en planilla de base de datos, para su posterior análisis estadístico. Resultados: De las 2.078 biopsias del territorio bucal, 31 corresponden a tumores odontogénicos, lo que representa un 1,5% de todas las lesiones biopsiadas del territorio oral. Una lesión maligna fue encontrada y corresponde a carcinoma ameloblástico infiltrante. La lesión más frecuente correspondió a tumor odontogénico queratoquístico (41,9%, seguido por el ameloblastoma (22,6% y, por último, odontoma (16,1%. El promedio de edad de 35,7 años. El área más frecuente de presentación es el área molar mandibular (54,8%. Conclusión: Los tumores odontogénicos son de baja prevalencia en la población valdiviana atendida en el Hosptial Base Valdivia entre los años 1989-2008. No tiene predilección por género. La lesión más prevalente es el tumor odontogénico queratoqísitico.

  13. Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms

    Science.gov (United States)

    TANIO, SHUNSUKE; MATSUSHITA, MICHIKO; KUWAMOTO, SATOSHI; HORIE, YASUSHI; KODANI, ISAMU; MURAKAMI, ICHIRO; RYOKE, KAZUO; HAYASHI, KAZUHIKO

    2015-01-01

    It was recently demonstrated that ~80% of Merkel cell carcinomas (MCCs) harbour a novel polyomavirus, Merkel cell polyomavirus (MCPyV). MCPyV has been detected in various human tissue samples. However, previous studies on the prevalence of MCPyV in oral tumours or tumour-like lesions are incomplete. To address this issue, we measured MCPyV DNA quantity using quantitative polymerase chain reaction (qPCR) in 327 oral tumours or tumour-like lesions and 54 jaw tumours or cyst lesions from 381 immunocompetent patients, as well as in 4 oral lesions from 4 immunosuppressed patients. qPCR revealed a low MCPyV prevalence (25/381, 6.6%) with low viral loads (0.00024-0.026 copies/cell) in oral and maxillofacial tumours and tumour-like lesions from immunocompetent patients. The prevalence was 7/176 (4.0%) in invasive squamous cell carcinomas (SCCs) [2/60 (3.33%) SCCs of the tongue, 4/52 (7.7%) SCCs of the gingiva and 1/19 (5.3%) SCCs of the floor of the mouth], 1/10 (10%) in dysplasias, 1/5 (20%) in adenocarcinomas, 2/13 (15.4%) in adenoid cystic carcinomas, 1/10 (10%) in non-Hodgkin's lymphomas, 3/10 (30%) in lipomas, 3/5 (60%) in neurofibromas, 1/3 (33.3%) in Schwannomas, 2/12 (16.7%) in Warthin's tumours, 2/11 (18.2%) in pyogenic granulomas, 1/14 (7.1%) in radicular cysts and 1/12 (8.3%) in ameloblastomas. The prevalence in lesions from immunosuppressed patients (1/4, 25%) was higher compared with that in lesions from immunocompetent patients (25/381, 6.6%), but the difference was not statistically significant. To the best of our knowledge, this study was the first to report prevalence data of MCPyV in tumours and cysts of the jaws (2/54, 3.7%). These data indicated absence of MCPyV-related tumours or tumour-like lesions in the oral cavity and jaws and suggested that the detected MCPyV DNA was derived from non-neoplastic background tissues with widespread low-level MCPyV infection. PMID:26807237

  14. 眉弓上锁孔入路显微手术切除大型颅咽管瘤%Microsurgical resection of large craniopharyngiomas via supraorbital keyhole approach

    Institute of Scientific and Technical Information of China (English)

    雷鹏; 王钰; 田立桩; 刘奇

    2011-01-01

    Objective To summarize the experience in microsurgical resection of large craniopharyngiomass via supraorbital keyhole approach.Methods Clinical data of 31 patients with craniopharyngioma verified by surgery and pathology were analyzed retrospectively.The surgical strategies were performed as follows: exposure of the tumor, preservation of important nerves and vessels, and tumor removal with piece by piece in operation.The complications were actively managed after operation.Results Total tumor removal was achieved in 24 cases and partial removal in 7.The diagnosis was established by postoperative pathological analysis, including 12 ameloblastomas, 15 squamous epithelial carcinomas and 4 undifferentiated-type carcinomas.Postoperatively diabetes insipidus aggravated in 7 cases and hypernatremia occurred in 2, drowsiness in 3, hyperpyrexia in 4, visual impairment in 2 and death in 1.The residual tumor was given radiotherapy or stereotactic radiosurgical treatment.Thirty patients were followed up for mean of 3.9 years,ranged from 3 months to 7.2 years.The symptoms were improved to different extents postoperatively.The tumors recurred in 4 cases.Conclusions Microsurgical resection of large craniopharyngioma via supraorbital keyhole approach is a minimally invasive and safe operative method and can obtain satisfactory clinical outcome.%目的 总结经眉弓上锁孔入路显微手术切除大型颅咽管瘤的手术经验.方法 回顾性分析31例颅咽管瘤病人的临床资料.均经手术和病理证实.术中采用显露肿瘤,保护重要血管和神经,分块切除肿瘤的策略;术后积极处理并发症.结果 肿瘤伞切24例,大部切除7例.术后病理检查显示:成釉细胞型12例,鳞状上皮型15例,未分型4例.术后尿崩症加重7例,高钠综合征2例,嗜睡3例,高热4例,视力损害加重2例;死亡1例.残余肿瘤给予常规放疗或立体定向放射外科治疗.30例随访3个月~7.2年,平均3.9年.术前症状均

  15. A statistical study of the maxillofacial diseases by radiograms

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yoo Tai; Lee, Sang Chull [College of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    1974-11-15

    This report based on 300 cases of serious diseases in maxillofacial region by radiograms seen at the department of dental radiodontics, infirmary school of dentistry, Kyung Hee University from October 1971 to August 1974. The maxillofacial diseases were analysed upon the following items, such as 1) the frequency of dominant diseases, 2) sex-ratio of male to female, 3) predominant region of diseases, 4) comparison with the age, 5) the incidence of diseases in relative to the individual teeth. The results were obtained as follows. 1) Among the total of 300 cases of the patients, the frequency of dominant diseases of patients were fractures of facial bone (44.3 {+-} 2.87%), inflammatory diseases (22.7 {+-} 2.39%), cysts (11.1 {+-} 1.62%), tumors(10.7 {+-} 1.77%), maxillary sinusitis (7.9 {+-} 1.56%), temporomandibular joint disorders(3.3 {+-} 1.05%) in the order. 2) The sex ratio of male to female in occurrence of jaw fractures were 7.3 : 1, temporomandibular joint disorders were 2.1 : 1, inflammatory diseases were 1.8:1, maxillary sinusitis were 1.7 : 1, but tumors were 1: 1, while cysts were 1:1 .2 in sex difference.3) The predominant region of mandibular fractures were symphysis (17.3 {+-} 3.27%), canine region (15.0 {+-} 3.09%), and angle region(14.3 {+-} 3.04%) in the order. Inflammatory diseases were occurred frequently in mandible and it's left side were a little dominant. Odontogenic cysts were observed frequently in maxilla, but regardless of right and left. Carcinomas were involved most frequently in maxilla, while sarcomas and ameloblastomas in mandible. Frequency of the maxillary sinusitis w ere dominant in right side and molar area, also temporomandibular joint disorders were dominant in right side. 4) To study comparing with the age, jaw fractures showed the highest ratio at the 2nd decade (32.3 {+-} 4.06%), and 3rd decade (27.8 {+-} 3.89%), 4th decade (19.6 {+-} 3.44%), 6th decade (9.0 {+-} 2.47%), 5th decade(6.0 {+-} 2.06%), lst decade(5.3 {+-} 1

  16. 青少年颌骨囊性病变362例临床资料分析%A Retrospective Clinicopathological Analysis of 362 Jaw Cysts in Adolescents

    Institute of Scientific and Technical Information of China (English)

    张新宇; 刘浏; 胡永杰; 张陈平

    2015-01-01

    目的:了解目前青少年颌骨囊性病变的构成现状,为临床诊疗提供帮助。方法:回顾性分析2003-01—2013-12间,于我科住院治疗的362例青少年颌骨囊性病变的临床资料,对其分类、性别、年龄、发病部位、治疗方法进行分析。结果:362例中成釉细胞瘤109例,牙源性角化囊性瘤107例,含牙囊肿48例,根尖囊肿24例,其他74例。平均年龄14.93岁,男女比例1.63∶1。下颌骨受累226例,上颌骨受累140例,26例患者上下颌骨同时受累,22例患者影像资料缺失,左右颌骨发病率基本相同,颌骨任一部位均可发生囊性病变,但下颌磨牙及下颌升支区为最易受累部位。结论:青少年颌骨囊性病变好发于下颌骨,男性发病率较女性高,其治疗及预后与成年人有差异,临床诊治中应注意其相应变化。%Objective: To investigate the current status of jaw cystic lesions in the adolescent patients. Methods: Retro-spective analysis of 362 cases of adolescents jaw cystic lesions treated in our department from January 2003 to Decem-ber 2013. Clinical data included cyst classification, gender, patients' age, location of the cyst, and therapeutic measures. Results: In the 362 cases, ameloblastoma 109 cases, odontogenic keratocysts 107 cases, dentigerous cysts 48 cases, radicular cysts 24 cases, and 74 other jaw cysts. Age of patients ranged from 10 to 19 years old, with a mean of 14.93 years. The distribution between males and females were about 62.15%(225/362) males to 37.85%(137/362) females (1.64∶1). 226 cases (62.43%) located in the mandible, 140 cases(38.67%) located in the maxilla. In 26 cases whose cysts located in both mandible and maxilla. In 22 cases, whose X-ray radiographs were lost. The morbidity of jaw cystic lesions is the same in both side of the jaw. The most prevalent locations of adolescent jaw cysts were the mandibular molar area and ra-mus. Conclusion: Jaw cystic lesions

  17. 咬合导板及颌间牵引钉技术在游离腓骨瓣修复下颌骨缺损中的应用%APPLICATION OF OCCLUSAL GUIDE PLATE COMBINED WITH INTERMAXILLARY FIXATION SCREW IN MANDIBULAR DEFECT REPAIR WITH FREE FIBULAR FLAP

    Institute of Scientific and Technical Information of China (English)

    杨志诚; 向旭; 严颖彬; 史平; 王超

    2013-01-01

    Objective To investigate the clinical value of occlusal guide plate combined with intermaxillary fixation screw in mandibular defect repair with free fibular flap. Methods Between August and December 2011, 7 patients with mandibular tumor were treated, including 5 cases of ameloblastoma and 2 cases of gingival cancer. Of 7 patients, 4 were males and 3 were females, aged 32-65 years (median, 50 years). Occlusal guide plate was prepared and the implanted position of intermaxillary fixation screws was determined preoperatively. Hemimandibulectomy was performed in 5 cases, half mandibular segmental resection with condyle reservation in the other 2 cases. The free fibular flaps of 11-13 cm in length were harvested for repairing mandibular defects. When the free fibular flaps were fixed, the occlusal guide plate and intermaxillary fixation screws were utilized to restorate the occlusal relation. The donor site was sutured directly. Results The average operation time was 9.5 hours (range, 7-12 hours). All free fibular flaps survived completely. All incisions at the donor site and recipient site healed by first intention. All patients were followed up 10-14 months with an average of 12.3 months. All patients had symmetrical face, good occlusal relation, normal mouth opening, and normal mandibular lateral movement, and no pain of bilateral temporomandibular joints occurred. Panoramic tomography showed good mandibular contour and the suitable emplacement of fibular flaps postoperatively. No tumor recurrence occurred during follow-up period. Conclusion When repairing the mandibular defect with free fibular flap, occlusal guide plate with intermaxillary fixation screw contributes to simplifying operation, accurate recovery of the appearance and occlusal relation, and improving the oral comfort level postoperatively.%目的 探讨咬合导板及颌间牵引钉技术在游离腓骨瓣修复下颌骨缺损中的应用价值.方法 2011年8月-12月,收治7