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Sample records for ameloblastoma

  1. Radiographic study of ameloblastoma

    International Nuclear Information System (INIS)

    The purpose of this study is to obtain some information for the differential diagnosis of ameloblastoma from dentigerous cyst by analysis of the radiographic findings of these lesions. The author studied age and sex distribution, the site of the lesion, tooth behavior and several radiographic features of ameloblastoma and dentigerous cyst. The material consisted of 65 patients of ameloblastoma and 37 patients of dentigerous cyst. The results were obtained as followings. 1) The incidence was highest in 2nd decade (29.2%) and total 65 cases consists of 35 males (53.8%) and 30 females (46.2%) in ameloblastoma. 62 cases were found in lower jaw (95.4%) and the highest site of occurrence of ameloblastoma was mandibular molar region 27 cases.(41.5%) 2) In 65 cases of ameloblastoma, 18 cases were seen in association with tooth and 15 cases (83.2%) out of those were associated with mandibular molar teeth. Mandibular molar were most frequently involved in dentigerous cyst (11/37 cases, 29.7%). 3) (a) 23 cases (35.3%) of tooth resorption were found in ameloblastoma and 11 cases (29.7%) of tooth resorption were found in dentigerous cyst. (b) 15 cases (23.1%) of tooth migration were found in ameloblastoma and 10 cases (27.0%) of tooth migration were found in dentigerous cyst. 4) Several radiographic features. (a) Monolocular type ameloblastoma were seen in 23 cases (35.4) and multilocular type of ameloblastoma were seen in 42 cases (64.6%). Monolocular type of dentigerous cyst were seen in 33 cases (89.2%) and multilocular type was seen in 4 cases. (b) Monolocular type ameloblastoma showed 20 cases (87.0%) of scalloped border but 32 cases (97.0%) of dentigerous cyst showed smooth border. (c) 34 cases (81.0%) of ameloblastoma showed honey-comb appearance, soap-bubble appearance or mixed appearance. But all 4 cases of dentigerous cyst showed multicystic appearance. (d) 12 cases (52.2%) of monolocular type ameloblastoma showed slightly increased radiopacity in surrounding bone

  2. Ameloblastoma in children; Ameloblastoma u dzieci

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    Korzon, M.; Popadiuk, S.; Bohdan, Z. and others [Akademia Medyczna, Gdansk (Poland)

    1993-12-31

    Two cases of ameloblastoma in 3 and 12 year old children are described. The difficulties in the diagnosis and treatment of this rare tumor of the jaws (mandibula) are presented. Only a short remission following chemotherapy was achieved in both cases. (author) 19 refs, 2 figs

  3. Imaging diagnosis of ameloblastoma

    International Nuclear Information System (INIS)

    Ameloblastomas are ondontogenic tumors of the upper and lower jaw. The ameloblastomas are supposed to be benign with slow growth, but locally invasive growth is possible. Contrast agent enhanced CT seems to have the largest imaging potential to differentiate between benign and malign osteogenic processes. In general - dependent on localization, histological type and neighboring tissues - the radical resection with following plastic reconstruction seems to be the best therapeutic decision.

  4. Recurrent ameloblastoma of the mandible

    OpenAIRE

    Joshi, C P; Vyas, K. C.; Deedwania, Seema; Jain, Sanjeev; Mangal, M. M.

    1999-01-01

    Ameloblastoma is an agressive locally recurring neoplasm of odentogenic epithelium. Here we describe a case of mandibular ameloblastoma with 12 yrs. history of local recurrences followed with history of excision twice (10 yrs. and 7 years back).

  5. Hybrid ameloblastoma: An amalgam of rare and conventional ameloblastoma.

    Science.gov (United States)

    Chaitanya, B; Chhaparwal, Yogesh; Pai, Keerthilatha M; Kudva, Adarsh; Cariappa, K M; Acharya, Shruthi

    2016-01-01

    Ameloblastoma is a common benign odontogenic tumor with multiple histologic types. This case report describes an unusual type of ameloblastoma called "Hybrid Ameloblastoma" with features of both follicular and desmoplastic ameloblastoma in a 50-year-old female. This is a very rare form of ameloblastoma as <30 cases have been reported so far in literature. Though this rare form of ameloblastoma is only a histologic variant, it poses a great challenge to diagnosticians and thus to surgeons as there will be mismatch of biopsy reports at different sites in the same tumor thereby changing the treatment plan. This case report is one such example of diverse presentation of this ameloblastoma with conflicting histopathological diagnosis at initial biopsy and on surgical excision. PMID:27041910

  6. Overwhelming hypercalcaemia in mandibular ameloblastoma.

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    Lo, Tom Edward Ngo; Villafuerte, Cesar Vincent; Acampado, Laura Trajano

    2014-01-01

    Ameloblastoma is considered to be a benign odontogenic tumour of epithelial in origin that is slow growing but recurrent and invasive in nature. Some of its features have been sources of debate among experts regarding its benign or malignant character. We report a case of a 20-year-old Filipino woman with right mandibular ameloblastoma presenting with overwhelming hypercalcaemia. Work ups for hypercalcaemia eventually revealed tumoral hypercalcaemia, which was initially controlled with intravenous bisphosphanate. The patient eventually underwent tumour excision and mandibular reconstruction, which totally corrected hypercalcaemia. This case will highlight the rare association of hypercalcaemia among patients with ameloblastoma. PMID:25326561

  7. Plexiform Unicystic Ameloblastoma: A Rare Variant of Ameloblastoma

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    Swapnil S. Deore

    2014-01-01

    Full Text Available The term plexiform unicystic ameloblastoma refers to a pattern of epithelial proliferation that has been described in cystic cavity. Because of unilocular presentation, it is commonly misdiagnosed as an odontogenic cyst. However, they may often behave clinically as biologically aggressive tumors. These tumors show high incidence of cortical perforation, tooth resorption and a high rate of recurrence after simple enucleation. This paper aims to provide an insight into this biologically distinct entity. A literature review on the topic has been added along with a case report highlighting the approach of diagnosis and management of such ameloblastomas.

  8. Manejo quirúrgico del ameloblastoma Surgical management of ameloblastoma

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    Adaia Valls

    2012-09-01

    Full Text Available El ameloblastoma es un tumor odontogénico de estirpe epitelial. Aunque se clasifica como una tumoración benigna, suele ser localmente agresiva presentando elevada invasión local, con gran tendencia a la recidiva y con posibilidad metastásica ocasional. Se manifiesta preferentemente durante la tercera, cuarta y quinta décadas de la vida, sin predilección por razón de sexo, aunque puede darse en cualquier grupo de edad, incluidos los niños. La mayoría de los ameloblastomas se encuentran sobre todo en mandíbula (al nivel del ángulo y rama. En el tratamiento se debe valorar su tipología clínica (sólido, multiquístico, uniquístico, mixto o periférico, su localización y el tamaño del tumor, así como la edad y las condiciones clínicas del paciente. Presentamos una revisión de los pacientes afectos de ameloblastomas tratados en nuestro Centro durante los últimos 10 años. Se aportan datos acerca de su aparición clínica, sus características histológicas, el manejo terapéutico realizado y analizamos el seguimiento y comparamos la aparición de recidivas en los pacientes presentados. Las características clínicas, incluso si se complementan con radiografías y/o muestras histológicas, no son siempre determinantes del comportamiento biológico y, por tanto tampoco lo son del pronóstico de un ameloblastoma individual.The ameloblastoma is an odontogenic tumour of epithelial origin. Although it is classified as benign, there is usually aggressive local invasion, a great tendency to recurrence, and occasional metastatic potential. It generally appears during the third, fourth and fifth decades of life, without gender predilection, although it can occur at any age, including in children. Ameloblastomas are mostly found in the mandible (angle and branch. In treatment, its clinical type (solid, unicystic, desmoplastic, mixed or peripheral, its location and size, must be assessed, as well as the age and clinical condition of the

  9. A radiologic study of ameloblastoma using computed tomography

    International Nuclear Information System (INIS)

    To reveal what is the distinct differential diagnostic differences between uni cystic ameloblastoma and solid or multicystic ameloblastoma. 56 cases of ameloblastoma were retrospectively reviewed and evaluated among the patients who had taken CT scans at the department of Oral and Maxillofacial Radiology in Yonsei University Dental Hospital form January 1996 to December 2003. In 56 cases, 21 cases (37.5%) were uni cystic ameloblastoma, 35 cases (62.5%) were solid or multicystic ameloblastoma. Only 1 case (4.8%) of uni cystic ameloblastoma and 4 cases (11.4%) of solid or multicystic ameloblastoma were occurred in maxilla. 13 cases (61.9%) of uni cystic ameloblastoma were observed as unilocular, and 8 cases (38.1%) as lobulated. 5 cases (14.3%) of solid or multicystic ameloblastoma were observed as unilocular, 13 cases (37.1%) as lobulated, and 17 cases (48.6%) as multilocular. In the results from the measurements after correction of the buccolingual widths and heights to the mesiodistal lengths, there is a statistically significant difference between uni cystic ameloblastoma and solid or multicystic ameloblastoma in ANCOVA test (p0.05). Characteristic difference between unicystic ameloblastoma and solid or multicystic ameloblastoma is that there is higher prevalence of solid or multicystic ameloblastoma that have lobulated or multilocular patterns. To measure the Hounsfield units in the lesion is helpful, but it is not a differential diagnostic point between uni cystic ameloblastoma and solid or multicystic ameloblastoma.

  10. Aggressive granular cell ameloblastoma: Report of a rare case

    OpenAIRE

    N Aravindha Babu; S Leena Sankari; Anitha, N.; Gouse Mohideen

    2015-01-01

    Granular cell ameloblastoma is a slow growing odontogenic ectodermal tumor. The tumor shows typical ameloblastoma with the cells showing eosinophilic granularity. This variant of ameloblastoma is aggressive with high recurrence rates. We report a case of aggressive ameloblastoma of granular cell variant

  11. Imaging diagnosis of ameloblastoma; Bildgebung bei Ameloblastomen

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    Esser, M.; Horger, M.; Ioanovicu, S.D.; Boesmueller, H.

    2015-10-15

    Ameloblastomas are ondontogenic tumors of the upper and lower jaw. The ameloblastomas are supposed to be benign with slow growth, but locally invasive growth is possible. Contrast agent enhanced CT seems to have the largest imaging potential to differentiate between benign and malign osteogenic processes. In general - dependent on localization, histological type and neighboring tissues - the radical resection with following plastic reconstruction seems to be the best therapeutic decision.

  12. Unusual imaging appearance of unicystic ameloblastoma

    OpenAIRE

    Lakshmi Kavitha Nadendla

    2012-01-01

    Unicystic ameloblastoma (UA) refers to those cystic lesions that show clinical, radiographic, or gross features of a mandibular cyst, but on histologic examination show a typical ameloblastous epithelium lining part of the cystic cavity, with or without luminal and/or mural tumor growth. It accounts for 5-15% of all intraosseous ameloblastomas. We report a case of UA in a 35-year-old female with an unusual large multilocular (tennis racket) appearance on the right body of mandible and illustr...

  13. Radiotherapy in the treatment of ameloblastoma

    International Nuclear Information System (INIS)

    There is a lack of well-documented evidence in the literature concerning the relative radioresponsiveness or radioresistance of ameloblastomas, although they are generally considered radioresistant. Most of the previous papers referring to this subject lack acceptable histopathologic proof of the diagnosis, adequate radiotherapeutic data, and/or follow-up information; many predate the use of megavoltage irradiation. The present article reports 5 cases of ameloblastoma that were treated by radiotherapy, 3 by megavoltage irradiation. All have been confirmed histologically by an oral pathologist, all have adequate radiotherapeutic data and, with one exception, adequate follow-up information. In addition, the reasons for our present lack of knowledge of this subject are discussed; objective criteria are presented for evaluating the results of radiotherapy on ameloblastomas; the only other series of ameloblastomas treated by megavoltage irradiation is analyzed. Although radiotherapy can reduce the size of an ameloblastoma, primarily that part of the tumor which has expanded the jaw or broken into the soft tissues, it does not appear to be an appropriate treatment for an operable ameloblastoma. Its main use is in inoperable cases, primarily in the posterior maxilla. (author)

  14. Calretinin as a Diagnostic Adjunct for Ameloblastoma

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    Chitra Anandani

    2014-01-01

    Full Text Available Background. Calretinin is a 29 kDa calcium-binding protein of the EF-hand family which is expressed in a variety of normal and tumorigenic tissues. Its expression in odontogenic epithelium during odontogenesis and in neoplastic odontogenic tissues has been demonstrated. Unicystic ameloblastoma poses a diagnostic challenge, as its histologic presentation can be sometimes mistaken for keratocystic odontogenic tumor (KCOT. This study was performed to assess the usefulness of calretinin as a confirmatory marker for ameloblastic tissue. Methodology. Total of 40 cases: 16 unicystic ameloblastoma, 4 multicystic ameloblastoma, and 20 KCOT, were evaluated immunohistochemically for the presence, localization, distribution, and intensity of calretinin expression. Statistical analysis was done using Chi-square test to intercompare the expression between ameloblastoma and KCOT. Results. Sixteen cases of ameloblastoma (12 unicystic, 4 multicystic showed positive calretinin staining of ameloblastic epithelium and only one case of KCOT was positive for calretinin, with the positivity restricted to the stellate reticulum like epithelium. Intercomparison between two groups revealed statistically significant difference (P=0.000. Conclusion. Calretinin appears to be a specific immunohistochemical marker for neoplastic ameloblastic epithelium and may be an important diagnostic adjunct in the differential diagnosis of ameloblastoma and KCOT.

  15. Intraosseous ameloblastoma masquerading as exophytic growth: a case report

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    Ramachandra, Prashanth; Ramnarayan, BK; Sanjay, CJ; David, Chaya M [Dr Shyamala Reddy Dental College and Hospital, Bangalore (India); Kaul, Rachna [Dayananda Sagar College of Dental Sciences, Bangalore (India)

    2011-06-15

    Intraosseous ameloblastoma is the most common and simple type of ameloblastoma prevalent among odontogenic tumors. Clinico-radiographically intraosseous ameloblastoma presents as slow, painless swelling or expansion of the jaws and described as multilocular expansile radiolucency that occurs most frequently in mandibular molar/ramus area. This article describes a case of follicular ameloblastoma involving 45 year old male which is different from the usual presentation, which includes-exophytic growth, different location and without expansion of the cortex.

  16. Transmission electron microscopy of ameloblastoma: A study on six cases

    OpenAIRE

    Chawla, Rajeshwar; Ramalingam, Karthikeyan; Sarkar, Amitabha; Muddiah, Savita

    2013-01-01

    Background: Ameloblastoma is a rare, benign tumor of odontogenic epithelium, but with an aggressive clinical behavior. Aim: The present study aims to assess the ultramicroscopic features of the epithelial and connective tissue components of ameloblastoma. Materials and Methods: Six cases of ameloblastoma were subjected to electron microscopy. They included three cases of follicular type and three cases of plexiform type. Results: The study reveals that the ameloblastoma contains the full comp...

  17. Ameloblastoma of the frontal sinuses: a rare site for recurrence

    OpenAIRE

    Coombs, AC

    2011-01-01

    Ameloblastoma is a benign odontogenic tumour which commonly recurs after initial surgery; most recurrences occur at the site of the primary tumour. A rare case of recurrence of a maxillary ameloblastoma in the frontal sinuses is presented. To our knowledge there are no previous reports in the literature of a benign maxillary ameloblastoma extending into the frontal sinuses.

  18. Ameloblastoma: Our clinical experience with 68 cases

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    Benjamin Fomete

    2014-01-01

    Full Text Available Introduction: In this environment, previous workers have reported on the challenges of managing large sized ameloblastoma of the jaws with less than adequate facilities. The aim of this review is to present the management of 68 cases of ameloblastoma with emphasis on surgical care. Materials and Methods: Retrospective survey of case notes of patients with histopathologic diagnosis of ameloblastoma (using the criteria of Barnes et al., 2005 seen between January 2006 and August 2010 at the Maxillofacial Unit, Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria was undertaken. Data collected includes histopathological diagnosis, age, gender, clinical information on site of lesion, form of intubation and surgical procedure performed. Results: Out of 94 patients, 68 with histological diagnosis of ameloblastoma (59 mandibular and 9 maxillary were operated within the study period. The remainder (26 was not treated in hospital. Among 68 patients treated, more were males (38 than females (30, giving a male to female ratio of 1.3:1. The age range was between 14 and 74 years (mean-standard deviation. The duration of the symptoms ranged from 7 months to 24 years, most were follicular ameloblastoma (n = 13 followed by acanthomatous type (n = 7. Endotracheal intubation was the most common (n = 55 followed by fiber optic laryngoscopy (n = 8. The surgical approach most used was extended Risdon with intraoral (n = 24 followed by extended Risdon with lip split and intraoral (n = 17. Segmental resection (en block formed the bulk of our procedures (n = 22 followed by subtotal mandibulectomy (n = 16. Conclusion: The treatment of ameloblastoma remains controversial. Its destructive nature has left patients with wide defects difficult to reconstruct.

  19. Images of ameloblastoma: from radiography to tomography

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    Raúl Herrera-Mujica

    2015-07-01

    Full Text Available Odontogenic tumors are a group of lesions originated from odontogenesis course alterations. Within odontogenic tumors is ameloblastoma, its treatment probably is one of the most controversial, because its aggressive behavior, high recurrence and probably low malignancies. Radiographs play an important role in assessment from this tumor, but the limitation is they are in two dimensions exams. Cone beam computed tomography is a valuable tool because enable a comprehensive assessment of anatomical structures by multiple sections of the area. Therefore, evaluation of ameloblastoma is complete by cone beam computed tomography because bone structures do not show distortion neither magnification.

  20. Maxillary ameloblastoma: An enigma for the surgeon

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    S O Ajike

    2009-01-01

    Full Text Available Background:Ameloblastoma is a benign but locally aggressive odontogenic tumour. Worldwide, maxillary ameloblastoma is rare but its late detection renders adequate treatment difficult. Majority occur in the mandible with about 5-20% occurring in the maxillary bone. Objective: The purpose of this study was to analyze 21 cases of maxillary ameloblastoma seen and managed at the Oral and Maxillofacial Unit of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria and Alba Clinic and Medical Centre, Kaduna, Nigeria. Study Design:A retrospective study of cases of maxillary ameloblastoma from all cases of ameloblastoma seen from January 1993 to August 2008. Data with respect to patient′s sex, age, tumour location, clinical presentation, radiologic features, biological and histopathologic type, surgical treatment and recurrences were analyzed. Results:Out of 350 cases of ameloblastoma seen within the period, 21(6% Patients were with maxillary am eloblastoma. Of the 21 cases, there were 13 males and 8 females, a male female ratio of 1.6 to 1, with an age range of 17-55 years (mean = 38.14, peaking at the 4 th and 5 th decades of life (61.9%. Tumour duration was from 3 months to 14 years. There were 18 unilateral and 3 bilateral swellings. Clinically, maxillary ameloblastoma presented with grotesque swellings, with antral involvement in 19 cases, teeth mobility/exfoliation. Radiologically, there were 20 multilocular and 1 unilocular radiolucent lesions. The most common histopathologic type was follicular (11, 52.4%.there were 22 procedures done on 21 patients; 21 maxillectomies and 1 enucleation. Follow up period of 18 patients was between 3 months and 10 years from which 3(16.7% recurrences were observed. Conclusion:Ameloblastum a is uncommon in the maxilla. While maxillary ameloblastoma is indistinguishable histologically from its mandibular counterpart, it is very lethal. An excellent result achieved in this study was due to the radical mode of

  1. Radiographic analysis of ameloblastoma: A retrospective study

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    Chandramani More

    2012-01-01

    Conclusion: Radiographs are an important aid for the diagnosis of oral lesions of various types, especially those that involve bone. It is important for the practicing clinicians to know the salient features of ameloblastoma which are peculiar to the local population.

  2. A case report on desmoplastic ameloblastoma of anterior mandible

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    Sharma Lamichhane, Narayan; Liu, Qilin; Sun, Hongchen; Zhang, Wei

    2016-01-01

    Background Desmoplastic ameloblastoma (DA) is a rare variant that accounts for approximately 4–13 % of ameloblastoma, displaying significant differences in anatomical site, imaging, and histologic appearance. It has been included in WHO classification of head and neck tumor (WHO-2005) as a variant of ameloblastoma. The tumor resembles benign fibro-osseous lesion for being frequently occurring in the anterior region of jaws as a mixed radiopaque-radiolucent lesion. Case presentation We present...

  3. Plexiform ameloblastoma mimicking a periapical lesion: A diagnostic dilemma

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    Bina Kashyap

    2012-01-01

    Full Text Available Plexiform ameloblastoma is one of the variant of ameloblastoma, with specific histopathological features. It manifests as unilocular or multilocular radiolucencies in the mandible or maxilla. In very rare cases, it can appear as a localized periradicular radiolucent area and imitate an endodontic lesion. Reported here is a rare case of plexiform ameloblastoma in an uncommon location, which was misdiagnosed as periapical lesion of inflammatory origin and treated endodontically. Surgical enucleation was followed and diagnosis of plexiform ameloblastoma was confirmed on histological grounds.

  4. A GIANT CYSTIC GRANULAR AMELOBLASTOMA OF THE MANDIBLE

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    D.P VINUTH

    2013-07-01

    Full Text Available Granular cell ameloblastoma is a rare odontogenic tumor, accounting for 3.5% of all ameloblastoma cases. In most instances, it occurs as an admixture with other histo‐ logic patterns, particularly the follicular subtype. It is also considered an aggressive variant of the ameloblastoma with potential recurrence and malignant transformation. A 45 year‐old male patient reported with a gigantic swelling in the right region of the face since 7 years. His‐ topathologically, diagnosis of granular cell ameloblastoma showing cystic changes was established.

  5. Peripheral ameloblastoma. Case report and review of the literature

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    Maria LAZARIDOU

    2014-03-01

    Full Text Available Peripheral ameloblastoma is a rare, benign neoplasm of odontogenic origin which develops strictly extraosseously at the gingiva. Histollogically, it resembles intraosseous ameloblastoma. The aim of this study is to report a case of a peripheral ameloblastoma which presented as a painless mass on the left maxillary tuberosity in a 44-year-old male. Its clin-ical features and the details of its surgical treatment are discussed. Discussion: Peripheral ameloblastomas have a better prognosis of their intraosseous counterpart. Aggressive treatment is not recommended since these tumors rarely recur

  6. Images of ameloblastoma: from radiography to tomography

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    Raúl Herrera-Mujica; Andrés Agurto-Huerta; León Palti-Menéndez; Yazmín Pariamachi-Polino

    2015-01-01

    Odontogenic tumors are a group of lesions originated from odontogenesis course alterations. Within odontogenic tumors is ameloblastoma, its treatment probably is one of the most controversial, because its aggressive behavior, high recurrence and probably low malignancies. Radiographs play an important role in assessment from this tumor, but the limitation is they are in two dimensions exams. Cone beam computed tomography is a valuable tool because enable a comprehensive assessment of anatomic...

  7. MANAGEMENT OF LARGE AMELOBLASTOMA: A CASE REPORT

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    Rudagi B M

    2010-03-01

    Full Text Available Ameloblastoma, first recognized by Cusack in 1827, is a neoplasm of odontogenic epithelium, especially of enamel organ-type tissue that has not undergone differentiation to the point of hard tissue formation. It accounts for about 1% of all oral tumors and about 9-11% of odontogenic tumors. Ameloblastoma in the mandible can progress to a great size and cause facial asymmetry, displacement of teeth, malocclusion, and pathologic fractures. A case of large ameloblastoma of mandible in a 39 year old male patient is being reported. Patient had large swelling on left lower side of the jaw since 2 years. Swelling was approximately 15 X 10cm in size. Intraorally the swelling involved buccal and lingual cortical plates and was obliterating the vestibular space. Patient did not seek medical attention because swelling was painless. The patient was investigated and treated with surgical excision and was providedwith prosthesis to correct the post operative sequale. The patient showed uneventful recovery with no recurrence after a follow up of one year.

  8. Differential diagnosis between odontogenic keratocyst and ameloblastoma by computed tomography

    International Nuclear Information System (INIS)

    The objective of this study is to find the differentiating characteristics of ameloblastomas and odontogenic keratocysts of the jaw by analyzing computed tomography (CT) images of the lesions, clarify radiological characteristics associated with jaw lesions, and to make a diagnosis based on these findings. Test subjects were chosen among the patients who were diagnosed as having an odontogenic keratocyst or ameloblastoma at the Yonsei University Dental Hospital from January 1996 to December 2000 and had CT scans taken preoperatively. The subject pool was comprised of 51 cases of odontogenic keratocyst and 37 cases of ameloblastoma. The following measures were used for image analysis of the lesion : the anatomic location, CT pattern, mesiodistal width, buccolingual width, the ratios between mesiodistal width and buccolingual width, height, CT number, homogeneity of radiodensity, the appearance of a sclerotic rim, continuity of adjacent cortical bone, and displacement and resorption of adjacent teeth. Comparing the CT patten, mesiodistal width, buccolingual width, height, CT number, homogeneity, appearance of sclerotic rim, continuity of adjacent cortical bone, there were statistically significant differences between ameloblastoma and odontogenic keratocyst test subjects (p0.05). We compared odontogenic keratocysts and ameloblastomas in CT scans. They occurred most frequently in the posterior to the ramus of the mandible. The findings of patterns of the CT images showed that size and border of lesions were more aggressive in ameloblastomas than in odontogenic keratocysts. The internal contents represented an increased attenuation area (IAA) in odontopenic keratocyst. Odontogenic keratocysts were shown to have higher CT numbers than ameloblastomas.

  9. Recurrent unicystic ameloblastoma in mandibular anterior teeth area

    International Nuclear Information System (INIS)

    The unicystic ameloblastoma (UA) is a variant of the solid or multicystic ameloblastoma, a less encountered variant of the ameloblastoma. It appears more frequently in the second or third decade with no sexual or racial predilection. It is almost exclusively encountered asymptomatically in the posterior mandible. We report a case of a 43-year old patient with UA, who had previously undergone a surgical treatment on the same site about 1 year ago, this lesion recurred and presented as an exophytic gingival lesion in the anterior mandibular region.

  10. Quantitative AgNORs study in ameloblastomas = Análise quantitativa das AgNORs em ameloblastomas

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    Santos, Anna Corrêa

    2009-01-01

    Objetivo: Os ameloblastomas são tumores originados do epitélio odontogênico, inclusive daquele que reveste os cistos dentígeros (CD). O objetivo do presente trabalho foi avaliar a atividade proliferativa das áreas luminais e murais dos ameloblastomas unicísticos murais (AUM), ameloblastomas convencionais (AC) e cistos dentígeros (CD), comparando seus comportamentos biológicos. Metodologia: Para tanto foram selecionados 10 casos de AC, 10 casos de AUM e 10 amostras de CD. A análise quantificat...

  11. Massive granular cell ameloblastoma with dural extension and atypical morphology

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    Vandana Raghunath

    2014-01-01

    Full Text Available Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ectoderm that occasionally reach a gigantic size. Giant ameloblastomas are a rarity these days with the advent of panoramic radiography in routine dental practice. Furthermore, the granular cell variant is an uncommon histological subtype of ameloblastoma where the central stellate reticulum like cells in tumor follicles is replaced by granular cells. Although granular cell ameloblastoma (GCA is considered to be a destructive tumor with a high recurrence rate, the significance of granular cells in predicting its biologic behavior is debatable. However, we present a rare case of giant GCA of remarkable histomorphology showing extensive craniofacial involvement and dural extension that rendered a good prognosis following treatment.

  12. PERIPHERAL AMELOBLASTOMA - A CASE-REPORT AND REVIEW OF THE LITERATURE

    NARCIS (Netherlands)

    NAUTA, JM; PANDERS, AK; SCHOOTS, CJF; VERMEY, A; ROODENBURG, JLN

    1992-01-01

    Peripheral ameloblastoma is a benign odontogenic tumor with the same histological characteristics as the centrally located ameloblastoma, but appearing in the gingiva and mucosa of the tooth-bearing area of the jaws. A review is presented of 53 cases: 45 being reported as peripheral ameloblastoma an

  13. Hybrid Ameloblastoma of the Maxilla: A Puzzling Pathology

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    Lakshmi, Chintamaneni Raja; Bhavana, Sujana Mulk; Nallamilli, Sai Madhavi; Prabhat, Meka Poorna Venkata; Sarat, Gummadapu; Anuradha, Chennupati

    2016-01-01

    Ameloblastomas are slow growing, locally invasive, benign odontogenic tumors of an epithelial origin, accounting for approximately 1% of all oral tumors. A 40-year-old man presented with a chief complaint of a swelling over the left side of his face of 4 years’ duration. On examination, gross facial asymmetry was detected, and a well-defined swelling was noted intraorally involving the left maxilla medially from the mid palatal raphe and obliterating the buccal vestibule laterally. The swelling was non-tender and exhibited dual consistencies: firm in the palate and cystic in the vestibular region. Computed tomography revealed a multilocular radiolucency, which involved the left maxilla, encroached into the left maxillary sinus and the nasal complex, and caused bony erosion. Early diagnosis and treatment are the key tools in managing ameloblastomas, failure of which may lead to a significant deterioration of the prognosis and an increased recurrence rate. Uncommon variants of ameloblastomas have been gaining interest recently. To date, 25 cases of hybrid ameloblastomas have been documented in the scientific literature. We present an extremely rare hybrid type of the ameloblastoma with combined follicular, cystic, acanthomatous, and desmoplastic variants, which render it the first of its kind to have ever been reported. PMID:27365557

  14. Basal cell ameloblastoma: a rare case report and review of literature

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    Nidhi Sharma

    2010-01-01

    Full Text Available Ameloblastomas are an enigmatic group of oral tumors. The name implies a resemblance tocells of the enamel-forming organ. The general agreement that ameloblastomas areodontogenic in origin occurs largely on the basis of the histologic similarities of the tumorand the developing enamel organ. Basal cell ameloblastoma is believed to be the raresthistologic subtype. It is reported to occur primarily in peripheral location but has been seenintraosseously, albeit rarely. Till date only 6 cases of Basal cell Ameloblastoma has beenreported in literature out of which five were in 3rd – 4th decade and only one case wasreported in 2nd decade. Numerous cases of ameloblastomas have been reported in adults inthe literature. However, only a few articles discuss ameloblastomas in children andadolescents. Considering the rarity of the lesion, we report here an interesting and uniquecase of Basal cell ameloblastoma of the mandible occurring in a very young patient.

  15. Unicystic plexiform ameloblastoma with mural proliferation: a full-blown lesion.

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    Anchlia, Sonal; Bahl, Sumit; Vyas, Siddharth; Raju, Godishala Swamy Sugunakar

    2016-01-01

    Ameloblastoma is the most common aggressive benign odontogenic tumour of the jaws and has received considerable attention due to its frequency, clinical subtypes and high tendency to infiltrate and recur. There are various types of this tumour and confusion still exists among clinicians as to its correct classification. Multicystic ameloblastoma is the most frequent subtype while unicystic ameloblastoma can be considered a variant of the solid or multicystic subtype. Unicystic ameloblastoma is considered a less aggressive tumour with a variable recurrence rate. However, its frequency is often underestimated. Ameloblastoma is often asymptomatic, presenting as a slowly enlarging facial swelling or an incidental finding on radiograph. It is seen in all age groups but is most commonly diagnosed in the third and fourth decades. We report a case of unusual unicystic ameloblastoma and present its clinical, radiological and full-blown histological changes and treatment modalities, providing new insights into ameloblastomas. PMID:27053538

  16. Clinicoradiologic Differential Diagnosis of Odontogenic Keratocyst and Ameloblastoma

    International Nuclear Information System (INIS)

    To clarify the clinical and radiologic parameters that can be used to differentiate odontogenic keratocyst and ameloblastoma. The records of 46 patients of ameloblstoma and 48 patients of odontogenic keratocyst at the Yonsei University Dental Hospital during the period of 1979 to 1995 were retrospectively reviewed. As a possible means for differentiating between the odontogenic keratocyst and ameloblastoma, the clinical parameters and the radiologic parameters were evaluated. In the clinical parameters, there was no significant deference in age, sex, and sign and symptoms (p>0.05).In the radiologic parameters, there was significant difference in site, shape of the lesion, and external root resorption of adjacent teeth (p<0.05). The site, shape of the lesion, and external root resorption of adjacent teeth can be the parameters to differentiate odontogenic keratocyst and ameloblastoma, but a definite differentiation of these two lesions needs a more specialized imaging modality.

  17. Mandibular ameloblastoma and maxillary adenoid cystic carcinoma: case report.

    Science.gov (United States)

    Tamme, Tiia; Leibur, Edvitar; Kulla, Andres

    2003-12-01

    We report the case of a 74-year-old woman who developed a follicular ameloblastoma of the right mandible and 22 months later developed a cribriform adenoid cystic carcinoma of the soft palate on the right maxilla. The ameloblastoma was treated by hemimandibulectomy, and the adenoid cystic carcinoma was managed by resection of the soft palate and the surrounding tissue and bone followed by a 6-week course of radiotherapy. Our review of the literature indicates that only one similar case has been previously reported where an odontogenic tumor and a salivary gland tumor involved two different anatomic locations in the same patient at nearly the same time. PMID:14702876

  18. Quality of life of patients surgically treated for ameloblastoma

    Science.gov (United States)

    Lawal, Hammed Sikiru; Adebola, Rafel Adetokunbo; Arotiba, Juwon Tunde; Amole, Ibiyinka Olushola; Efunkoya, Akinwale Adeyemi; Omeje, Uchenna Kelvin; Amole, Taiwo Gboluwaga; Adeoye, Joshua Biodun

    2016-01-01

    Background: The surgical management of ameloblastoma can have a profound functional and psychological effect on a patient's quality of life (QoL). The aim of this study was to compare the pre- and post-operative QoL outcomes of patients requiring surgical treatment for ameloblastoma. Patients and Methods: A total number of 30 patients were identified as fulfilling the criteria for this study. They included 18 males and 12 females, aged between 14 and 47 years with a mean of 27.3 years (standard deviation 10.2). Each patient completed a modified version of the University of Washington QoL questionnaire version 4, a day to surgery and postoperatively on the 7th day, 3 months, and 6 months. Results: Following surgical treatment of patients for ameloblastoma, the QoL decreased immediately after surgery. It then gradually improved over time and exceeded the preoperative value at 6 months postoperatively. When analyzed with respect to location, posteriorly placed tumors had the best postoperative QoL outcome. Patients expressed concern more about their appearance preoperatively while postoperative concerns were mostly focused on their ability to chew. Conclusion: Significant improvement occurred in QoL scores following surgical management of ameloblastoma. The small sample size utilized in this study limits a definitive conclusion. A larger multicenter study is therefore recommended.

  19. A repeatedly recurrent desmoplastic ameloblastoma after removal and allobone graft: Radiographic features compared with histological changes

    OpenAIRE

    Kim, Jae-Duk; Jang, Hyun-Seon; Seo, Yo-Seob; Kim, Jin-Soo

    2013-01-01

    A 40-year-old man suffered from a repeatedly recurrent desmoplastic ameloblastoma in the right maxillary anterior and premolar regions. During the first visit, the patient was provisionally histopathologically diagnosed with a developmental cyst, and it was confirmed to be unicystic ameloblastoma and resected. Four years later, the lesion recurred, and was diagnosed as a desmoplastic type of ameloblastoma and removed again. Then, 5 years after the second surgery, the lesion recurred again, an...

  20. Recurrent ameloblastoma in temporal fossa: A diagnostic dilemma

    OpenAIRE

    Sagar S Vaishampayan; Deepa Nair; Asawari Patil; Pankaj Chaturvedi

    2013-01-01

    Ameloblastoma is a unique, histologically benign but aggressive neoplasm of the jaws, arising from odontogenic epithelium with potency to cause extensive destruction of jaw bones and infiltration into the surrounding tissues. Recurrences are common after incomplete treatment. Recurrences can occur at difficult sites such as temporal and infratemporal fossa, orbit, anterior cranial base, paranasal sinuses etc. Fine needle aspiration cytology or core biopsy of these recurrent lesions may be mis...

  1. Molecular markers of tumor invasiveness in ameloblastoma: An update

    OpenAIRE

    Zhong, Yi; Guo, Wei; Wang, Li; CHEN, XINMING

    2011-01-01

    The aim of the present article was to review the current new knowledge on the molecular markers of tumor invasion in ameloblastoma. In this review, tumor molecular markers were identified and allocated to the following six groups according to their functions: (I) Markers involved in extracellular matrix degradation, (II) Molecular markers involved in cell adhesion lost, (III) Molecular markers involved in bone remodeling, (IV) Cytokines involved in angiogenesis, (V) Molecular markers related ...

  2. Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas.

    Science.gov (United States)

    Fregnani, E R; da Cruz Perez, D E; de Almeida, O P; Kowalski, L P; Soares, F A; de Abreu Alves, F

    2010-02-01

    The aim of this paper is to evaluate the clinical, radiographic, and histopathological findings and treatment modalities in all cases of ameloblastomas treated at the Sao Paulo Cancer Hospital, between 1953 and 2003. 121 case reports were retrieved from the medical files. Data were reviewed and statistical analysis was performed using Kaplan-Meyer method and Cox proportional risk model. The patients' age ranged from 2 to 82 years (mean 33.2 years), with a slight female prevalence. Most cases were located in the posterior mandible (80%). Radiographically, 60% showed a multilocular pattern. 113 casees were solid ameloblastomas, and plexiforme subtype was the most common. Solid tumours were treated by wide resection, curettage and criosurgery, or curettage alone, and unicystic tumours by curettage and/or cryotherapy. The global mean recurrence rate was 22%, with a mean follow-up of 9.7 years. The ameloblastomas were predominantly solid, affecting the posterior mandible. Important factors for outcome were radiographically multilocular lesions, the presence of ruptured basal cortical bone and histologically follicular tumours. PMID:20045283

  3. Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

    OpenAIRE

    Lee, Suk Keun; Kim, Yeon Sook

    2013-01-01

    Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke's pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The ...

  4. Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro

    International Nuclear Information System (INIS)

    Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas. Plasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were created and subsequently transfected into primary ameloblastoma cells. Zymography, RT-PCR, and Western blots were used to assess MMP-2 activity and expression of MMP-2 and TIMP-2, as well as protein levels. Primary cultures of ameloblastoma cells expressed cytokeratin (CK) 14 and 16, and MMP-2, but only weakly expressed CK18 and vimentin. MMP-2 mRNA and protein levels were significantly inhibited by RNA interference (P < 0.05). Both MMP-2 siRNA and TIMP-2 overexpression inhibited MMP-2 activity and the in vitro invasiveness of ameloblastoma. These results indicate that inhibition of MMP-2 activity suppresses the local invasiveness of ameloblastoma cells. This mechanism may serve as a novel therapeutic target in ameloblastomas pursuant to additional research

  5. Recurrent ameloblastoma in temporal fossa: A diagnostic dilemma

    Directory of Open Access Journals (Sweden)

    Sagar S Vaishampayan

    2013-01-01

    Full Text Available Ameloblastoma is a unique, histologically benign but aggressive neoplasm of the jaws, arising from odontogenic epithelium with potency to cause extensive destruction of jaw bones and infiltration into the surrounding tissues. Recurrences are common after incomplete treatment. Recurrences can occur at difficult sites such as temporal and infratemporal fossa, orbit, anterior cranial base, paranasal sinuses etc. Fine needle aspiration cytology or core biopsy of these recurrent lesions may be misleading. Clinical course and radiological features help immensely in these situations. Good communication between surgeon, radiologist, and pathologist is of paramount importance.

  6. Reconstruction of palate with buccal fat pad secondary to resection of desmoplastic ameloblastoma

    Directory of Open Access Journals (Sweden)

    Bhimappa Mallappa Rudagi

    2015-04-01

    Full Text Available Desmoplastic ameloblastoma (DA is an unusual variant of ameloblastoma exhibiting important differences in the anatomical distribution, radiographic features and histologic appearance compared with the classic type of ameloblastoma. The purpose of this paper is to report a case of DA in the anterior left maxilla and to describe a simple method of reconstruction with the use of buccal fat pad (BFP. BFP is an excellent choice for reconstruction of small to medium sized defects. It should be manipulated gently and hemostasis should be achieved meticulously during this surgery. It should not be sutured under tension.

  7. A clinical and radiologic consideration of Ameloblastoma of the jaw

    International Nuclear Information System (INIS)

    A clinical and radiologic study of 46 intrabony ameloblastomas were undertaken from the files of the Department Oral and Maxillofacial Surgery, Dental Hospital, Yonsei University for the years January 1979 through December 1993. The following results were obtained; 1. In the clinical findings, the mean age of patients was 34 years, with no sex predilection noted and the most frequent sign was swelling of the face or jaw. 2. In the radiological findings, the majority of tumors, 97.8% involved the mandible with the posterior regions favored, and 56.5% of the lesions were multilocular type. Radiologic types had no correlation with the age of patients. 3. In the histologic findings, 23.9% of lesions were follicular or mixed type. Histologic types had no correlation between the unicystic type and first decade of age was found by X2 test (P<0.05). 4. Among the qualified 18 patients treated with radical or conservative surgery, the recurrence rate was 33.3%. The difference of recurrent rate between the multilocular type (36.4%) and the unilocular type (28.6%)was not much. Conclusively, more detailed clinical and radiologic parameters should be added to clearly predict the biologic behavior of ameloblastoma.

  8. A repeatedly recurrent desmoplastic ameloblastoma after removal and allobone graft: Radiographic features compared with histological changes

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Duk; Jang, Hyun Seon; Seo, Yo Seob; Kim, Jin Soo [School of Dentistry, Chosun University, Gwangju (Korea, Republic of)

    2013-09-15

    A 40-year-old man suffered from a repeatedly recurrent desmoplastic ameloblastoma in the right maxillary anterior and premolar regions. During the first visit, the patient was provisionally histopathologically diagnosed with a developmental cyst, and it was confirmed to be unicystic ameloblastoma and resected. Four years later, the lesion recurred, and was diagnosed as a desmoplastic type of ameloblastoma and removed again. Then, 5 years after the second surgery, the lesion recurred again, and was diagnosed as a type containing a follicular pattern, recurrent ameloblastoma. A panoramic radiograph showed a multilocular and mixed radiolucent/radiopaque expansile lesion at the first visit, a unilocular cystic lesion confined to the premolar area at the second visit, and a small soap bubble appearance in the molar area in the final visit. Cone-beam computed tomographic images of the final recurrence of the tumor revealed multiple small cyst-like structures in the right maxillary anterior and posterior regions.

  9. Ameloblastoma relapse after 16 years of resection in symphysis of mandible sparing the bone graft

    OpenAIRE

    Ram, Rangila

    2010-01-01

    Ameloblastoma is a tumor derived from epithelium involved in odontogenesis. Although it is considered a benign tumor, its clinical behavior may be regarded as lying between benign and malignant. It is characterized by slow but persistent growth, local infiltration into adjacent tissues and recurrences; however, metastases are rare. Diagnosis mainly from tissue biopsy and characteristic finding on plain X-rays does assist in differentiating between types of ameloblastoma. The challenges in the...

  10. Radiographic differential diagnosis between ameloblastoma and odontogenic keratocyst: with emphasis on CT

    International Nuclear Information System (INIS)

    To evaluate clinical and radiographic differential diagnosis between ameloblastoma and odontogenic keratocyst (OKC) using clinical data, plain radiographs, and CT. 25 cases of ameloblastoma and 44 cases of OKC diagnosed in biopsy, were selected from the files stored in Department of Oral and Maxillofacial Radiology, Seoul National University Dental Hospital from 1999 to 2001, and evaluated using following criteria: sex and age, location, shape, border to normal bone tissue, effect to adjacent tissues, homogeneity in the lumen of the lesion, response of the cortical bone, long-to-short length (L/S) ratio of the lesion, and expansion angle of the cortex. Ameloblastoma and OKC were seen most frequently in third decades and no statistical significance was noted between both sexes. Ameloblastoma occurred most frequently in mandibular angle and ramus area (68%) and OKC at the maxillary molar (34.1%), and mandibular angle and ramus area (43.2%). The root resorption of the adjacent teeth, mandibular canal displacement, and the impaction of teeth were seen more frequently in ameloblastoma than in OKC. The L/S ratio measured in CT was largest in maxillary OKC cases, followed by mandibular ameloblastoma, and mandibular OKC (1.2, 1.8 and 2.4 respectively). The expansion angle of the cortex shows a statistically significant difference between ameloblastoma (48.8 .deg. C) and OKC (31.5 .deg. C). The numeric morphology (L/S ratio) and expansion angle of the cortical bone of the lesion measured in computed tomography can be used to differentiate the ameloblastoma and odontogenic keratocyst.

  11. Origin of Ameloblastoma From Basal Cells of the Oral Epithelium- Establishing the Relation Using Neuroectodermal Markers

    Science.gov (United States)

    Suneela, S; Narayan, T V; Shreedhar, Balasundari; Mohanty, Leeky; Shenoy, Sadhana; Swaminathan, Uma

    2014-01-01

    Background and Objectives: Basal cell layer of the oral epithelium has been rightfully regarded as a potential source of odontogenic tumours and cysts, but, without substantial evidence. Also, whether the basal cell layer retains within it, some properties of ectomesenchyme, which was imbibed during the early embryogenesis and hence its neuroectodermal relation, is not known. Here, an attempt is made to establish the hidden neuroectodermal potential of the oral epithelium, especially the basal layer, by observing the expression of known neuroectodermal markers, NSE (Neuron Specific Enolase), Synaptophysin and CD99. The expression of the same markers has also been studied in Ameloblastoma, connecting it with oral epithelium, in turn establishing basal cell layer as a potential source of Ameloblastoma. Materials and Methods: Sections of formalin fixed, paraffin embedded tissue samples of 20 cases of Ameloblastoma and 10 cases of Normal Retromolar mucosa, were stained immunohistochemically with NSE, Synaptophysin, CD99 and also with CK-19 and evaluated for positive expression. Results: Positive reaction was obtained in all the cases of Ameloblastoma and NRM (Normal Retromolar mucosa) with NSE, all the cases of Ameloblastoma and eight cases of NRM with Synaptophysin and in six cases of Ameloblastoma and NRM with CD99. The staining was diffuse and more marked in case of NSE than Synaptophysin and CD99. CK19 staining done to assure that the tissue antigenicity was maintained was positive in all the samples. Interpretation and Conclusion: A strong relationship between the neuroectoderm, Ameloblastoma and the basal layer of the oral epithelium is established by the study. It favours the hypothesis that the basal cell layer of oral mucosa may be the sought out culprit in most cases of the Ameloblastomas, especially those occurring in the non-tooth bearing area. This would call for the need to incorporate additional therapy in the form of mucosal striping along with the

  12. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma

    International Nuclear Information System (INIS)

    Highlights: • We studied the interaction between tumor cells and fibroblasts in ameloblastoma. • AM-3 ameloblastoma cells secreted significantly high IL-1α levels. • IL-1α derived from AM-3 cells promoted IL-6 and IL-8 secretion of fibroblasts. • IL-6 and IL-8 activated the cellular motility and proliferation of AM-3 cells. - Abstract: Ameloblastoma is an odontogenic benign tumor that occurs in the jawbone, which invades bone and reoccurs locally. This tumor is treated by wide surgical excision and causes various problems, including changes in facial countenance and mastication disorders. Ameloblastomas have abundant tumor stroma, including fibroblasts and immune cells. Although cell-to-cell interactions are considered to be involved in the pathogenesis of many diseases, intercellular communications in ameloblastoma have not been fully investigated. In this study, we examined interactions between tumor cells and stromal fibroblasts via soluble factors in ameloblastoma. We used a human ameloblastoma cell line (AM-3 ameloblastoma cells), human fibroblasts (HFF-2 fibroblasts), and primary-cultured fibroblasts from human ameloblastoma tissues, and analyzed the effect of ameloblastoma-associated cell-to-cell communications on gene expression, cytokine secretion, cellular motility and proliferation. AM-3 ameloblastoma cells secreted higher levels of interleukin (IL)-1α than HFF-2 fibroblasts. Treatment with conditioned medium from AM-3 ameloblastoma cells upregulated gene expression and secretion of IL-6 and IL-8 of HFF-2 fibroblasts and primary-cultured fibroblast cells from ameloblastoma tissues. The AM3-stimulated production of IL-6 and IL-8 in fibroblasts was neutralized by pretreatment of AM-3 cells with anti-IL-1α antibody and IL-1 receptor antagonist. Reciprocally, cellular motility of AM-3 ameloblastoma cells was stimulated by HFF-2 fibroblasts in IL-6 and IL-8 dependent manner. In conclusion, ameloblastoma cells and stromal fibroblasts behave

  13. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Fuchigami, Takao [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Kibe, Toshiro [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Koyama, Hirofumi; Kishida, Shosei; Iijima, Mikio [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Nishizawa, Yoshiaki [Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Hijioka, Hiroshi; Fujii, Tomomi [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Ueda, Masahiro [Natural Science Centre for Research and Education, Kagoshima University, 1-21-24 Koorimoto, Kagoshima 890-8580 (Japan); Nakamura, Norifumi [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Kiyono, Tohru [Department of Virology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuouku, Tokyo 104-0045 (Japan); Kishida, Michiko, E-mail: kmichiko@m2.kufm.kagoshima-u.ac.jp [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan)

    2014-09-05

    Highlights: • We studied the interaction between tumor cells and fibroblasts in ameloblastoma. • AM-3 ameloblastoma cells secreted significantly high IL-1α levels. • IL-1α derived from AM-3 cells promoted IL-6 and IL-8 secretion of fibroblasts. • IL-6 and IL-8 activated the cellular motility and proliferation of AM-3 cells. - Abstract: Ameloblastoma is an odontogenic benign tumor that occurs in the jawbone, which invades bone and reoccurs locally. This tumor is treated by wide surgical excision and causes various problems, including changes in facial countenance and mastication disorders. Ameloblastomas have abundant tumor stroma, including fibroblasts and immune cells. Although cell-to-cell interactions are considered to be involved in the pathogenesis of many diseases, intercellular communications in ameloblastoma have not been fully investigated. In this study, we examined interactions between tumor cells and stromal fibroblasts via soluble factors in ameloblastoma. We used a human ameloblastoma cell line (AM-3 ameloblastoma cells), human fibroblasts (HFF-2 fibroblasts), and primary-cultured fibroblasts from human ameloblastoma tissues, and analyzed the effect of ameloblastoma-associated cell-to-cell communications on gene expression, cytokine secretion, cellular motility and proliferation. AM-3 ameloblastoma cells secreted higher levels of interleukin (IL)-1α than HFF-2 fibroblasts. Treatment with conditioned medium from AM-3 ameloblastoma cells upregulated gene expression and secretion of IL-6 and IL-8 of HFF-2 fibroblasts and primary-cultured fibroblast cells from ameloblastoma tissues. The AM3-stimulated production of IL-6 and IL-8 in fibroblasts was neutralized by pretreatment of AM-3 cells with anti-IL-1α antibody and IL-1 receptor antagonist. Reciprocally, cellular motility of AM-3 ameloblastoma cells was stimulated by HFF-2 fibroblasts in IL-6 and IL-8 dependent manner. In conclusion, ameloblastoma cells and stromal fibroblasts behave

  14. Evaluation of Neoplastic Nature of Keratocystic Odontogenic Tumor Versus Ameloblastoma

    International Nuclear Information System (INIS)

    Although most of odontogenic tumors are benign, some of them will show locally destructive behavior, as keratocystic odontogenic tumor (KCOT) is now known as a benign but aggressive odontogenic neoplasm. The neoplastic characteristics in KCOT have been suggested from clinical as well as pathologic aspects. Matrix metalloproteinase-2 (MMP-2) is a gelatinase form of the MMPs family, which is a group of proteolytic enzymes that degrade many types of collagen. Cysteine aspartic acid-specific protease-3 (caspase-3) is the most downstream enzyme in the apoptosis-inducing protease pathway and is probably the most clearly associated with cell death. The aim of this study is to evaluate and compare the extracellular degradation potentiality (MMP-2) and apoptosis (caspase-3) of the epithelial lining in KCOT versus radicular cysts and ameloblastoma, in order to reinforce its classification as an odontogenic tumor. Material and Methods: Twenty-six surgical specimens including keratocyst odontogenic tumor (KCOT; n=l 1), ameloblastoma (AB; n=8) and radicular cysts (RC; n=7) were examined for expression of MMP-2 and caspase-3 using the immunohistochemical method. Results: For MMP-2 immuno expression, AB showed the statistically significant highest mean area percentage, followed by KCOT, while RC showed the statistically significant lowest mean area percentage. As for caspase-3, there was no statistically significant difference between KCOT and AB, while RC showed the statistically significantly lowest mean area percentage. Conclusion: Overexpression of MMP-2 protein related to growth and progression of lesions analyzed and may be one of the factors enhancing the recurrence of KCOT and invasion of AB. In addition, the epithelial lining of KCOT showed a high cell turnover reinforcing its classification as an odontogenic tumor

  15. Ameloblastoma uniquístico, bases del tratamiento conservador: Presentación de caso clínico y actualización de la bibliografía Conservative treatment of unicystic ameloblastoma: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Juan Argandoña Pozo

    2011-06-01

    Full Text Available El ameloblastoma se define como un tumor localmente agresivo e infiltrante, con alta capacidad de recidiva. Este comportamiento agresivo e infiltrante plantea el problema de una opción conservadora o radical de tratamiento, con las alteraciones funcionales, estéticas y psicológicas que ello implica. El ameloblastoma uniquístico se describe como una lesión con cuadros morfológicos particulares, comportamiento biológico menos agresivo que el ameloblastoma común, así como también una recurrencia menor frente al tratamiento conservador. Se presenta un caso clínico con el diagnóstico de ameloblastoma uniquístico tratado de forma conservadora mediante descompresión y posterior enucleación. Se actualiza la información sobre su tratamiento.Ameloblastoma is defined as a locally aggressive, infiltrating tumor with high recurrence capacity. This aggressive and infiltrating behavior conditions the choice of conservative or radical therapy and the functional, cosmetic and psychological consequences of this choice. Unicystic ameloblastoma is described as a lesion with specific morphological pictures, less aggressive biological behavior than common ameloblastoma and less recurrence with conservative therapy. A case of unicystic ameloblastoma treated conservatively by decompression and enucleation is reported. The therapeutic options are reviewed.

  16. Desmoplastic ameloblastoma mimicking a periapical lesion =Ameloblastoma desmoplásico mimetizando lesão periapical

    Directory of Open Access Journals (Sweden)

    Santos, Esaú Pinheiro dos et al.

    2010-01-01

    Full Text Available Ameloblastoma desmoplásico (AD é uma rara variante do ameloblastoma, com características clínicas, imaginológicas e histopatológicas específicas. O perfil biológico deste tumor não é totalmente compreendido, devido ao número limitado de casos notificados. O objetivo deste trabalho é relatar um caso de AD simulando uma lesão periapical. Este tumor apareceu na região anterior da maxila esquerda numa paciente do gênero feminino de 24 anos de idade, entre o incisivo lateral esquerdo e o canino. A lesão era indolor e apresentava apenas um ligeiro inchaço da mucosa do palato duro. Radiograficamente, uma área radiolúcida bem delimitada que promovia a divergência radicular foi observada. O incisivo lateral respondeu negativamente aos testes pulpares. Diagnóstico provisório de cisto radicular versus cisto fissural foi estabelecido e enucleação cirúrgica seguida de curetagem foi realizada. O exame histológico das amostras revelou a proliferação dos ninhos e cordões de epitélio odontogênico comprimido imersos em um estroma densamente colagenizado, associada a um trabeculado ósseo levemente irregular. Estas características eram consistentes com AD. A necrose pulpar do incisivo e o aparecimento radiográfico atípico, deixava a doença em absconso. Apesar das altas taxas de recorrência, nenhum sinal clínico ou radiográfico de recidiva do tumor foi detectado um ano mais tarde.

  17. Complete oral rehabilitation of a postresection ameloblastoma patient: a clinical case report.

    Science.gov (United States)

    Minichetti, John C; D'Amore, Joseph C; Schwarz, Evan

    2011-12-01

    Conventional ameloblastomas are rare, benign, epithelial odontogenic tumors that tend to grow slowly in the mandible or maxilla, but are locally invasive and can be highly destructive of the surrounding dental anatomy. Aggressive resection is the most effective method of eliminating the tumors, but treatment can further contribute to patient deformity and malfunction. Ameloblastomas also have a high rate of recurrence, which significantly diminishes 8 years after resection, but still requires vigilant clinical monitoring. This case report describes the complete oral rehabilitation of a postresection ameloblastoma patient with a mandibular reconstruction plate and partial edentulism. An autogenous graft was taken from the patient's iliac crest, shaped to fit the defect, and attached with bone screws. After graft incorporation, dental implants were successfully placed into the augmented ridge and restored with a fixed partial denture. There was no evidence of tumor recurrence during the 10 months of treatment or 8 years of subsequent clinical monitoring. PMID:21955211

  18. Conservative management of unicystic ameloblastoma in a young child: Report of two cases

    Directory of Open Access Journals (Sweden)

    Ritesh Kalaskar

    2011-01-01

    Full Text Available Unicystic ameloblastoma is a rare, benign, locally invasive odontogenic neoplasm of young age that show clinical, radiographic, or gross features of an odontogenic cyst, but histologically shows typical ameloblastomatous epithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth. The article presents atypical cases of a large, asymptomatic unicystic ameloblastoma of posterior maxilla and mandibular molar-ramus regions which were treated by surgical enucleation and application of Carnoy′s solution for 3 min. The article also describes the importance and complexity of differential diagnosis of an odontogenic lesion sharing common clinical and radiographical features.

  19. Practical significance of utilizing fine needle aspiration cytology as an adjunct diagnostic aid in the preoperative presumptive diagnosis of ameloblastoma

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    Sriram Kaliamoorthy

    2013-01-01

    Full Text Available Background: Cytological reports of ameloblastoma are relatively rare in the literature. Appropriate cytologic diagnosis may play a significant role in its preoperative presumptive diagnosis, especially when incisional biopsy findings are inadequate. Aim: To systematically study the detailed cytomorphologic features of ameloblastoma and to evaluate the role of fine needle aspiration cytology (FNAC in its preoperative diagnosis. Materials and Methods: In this study, FNAC was done on 26 cases of intra-osseous jaw lesion, clinically diagnosed as odontogenic tumor or developmental odontogenic cysts and detailed cytopathological interpretation was carried out and the results were correlated with the corresponding histopathology. Results: Of the 26 cases, 15 were found to be ameloblastoma and sensitivity of FNAC in the diagnosis of ameloblastoma was found to be 86.6%. None of the intra-osseous jaw lesion was false positively diagnosed as ameloblastoma in FNAC and hence the specificity was found to be 100%. Conclusion: Presence of cohesive epithelial cell clusters exhibiting smaller basaloid cells with peripherally placed tall columnar cells and occasional large squamous cells either adjoining the basaloid epithelial clusters or in isolated group aids in the specific cytological diagnosis of ameloblastoma and FNAC offers an excellent diagnostic aid that may play a significant role in preoperative presumptive diagnosis of ameloblastoma along with incisional biopsy.

  20. Accuracy and interobserver-intraobserver agreement in the radiologic diagnosis of ameloblastoma and odontogenic keratocyst

    International Nuclear Information System (INIS)

    Six observers with different amount of experience in the field of Oral and Maxillofacial Radiology interpreted the radiographs of 13 cases of ameloblastoma and 8 cases of odontogenic keratocyst which were confirmed histopathologically and showed pseudo-multilocular appearanced and scalloped border radiographically. The authors examined the accuracy of radiologic diagnoses, interobserver agreement and intraobserver agreement. The obtained results were as follows : 1. The accuracy of radiologic diagnosis ranged from 0.48 to 0.81. The average value was 0.61 2. The accuracy of radiologic diagnosis for ameloblastoma (0.55) was lower than that for odontogenic keratocyst (0.70) (P <0.05). 3. The overall agreement among the 6 observers was 14.3% at the first interpretation and 19.0% at the second interpretation. 4. The intraobserver agreement of each observer expressed in kappa index ranged from -0.14 to 0.64. The overall intraobserver agreement was 0.29. 5. The intraobserver agreement of each observer for ameloblastoma and odontogenic keratocyst ranged from -0.07 to 0.65 and from -0.25 to 1.00, respectively. The overall intraobserver agreement for ameloblastoma and odontogenic keratocyst were 0.27 and 0.26, respectively. 6. The diagnostic accuracy highly correlated to the intraobserver agreement (r=0.6370).

  1. Study of immunohistochemical demonstration of Bcl-2 protein in ameloblastoma and keratocystic odontogenic tumor

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    C S Sindura

    2013-01-01

    Full Text Available Background: The Bcl-2 (B-cell lymphoma gene product also known as apoptotic inhibitor is expressed in many normal and tumor tissues. This Bcl-2 gene protects the cell by blocking postmitotic differentiation from apoptosis, thus maintaining the stem cell pool. Objective: To study the expression of Bcl-2 protein in ameloblastoma and keratocystic odontogenic tumor (KCOT to determine their apoptotic behaviors and to analyze biological nature of KCOT, which has higher proliferative potential and aggressive clinical behavior like odontogenic tumors. Materials and Methods: Formalin-fixed paraffin sections of ameloblastoma (n = 20 and KCOT (n = 20 are considered for immunohistochemical analysis using monoclonal antibody against antihuman Bcl-2 oncoprotein. Lymphomas (n = 3 were used as controls. Statistical Analysis: The statistical analysis was performed using software package of social science version 16.The data were analyzed using Chi-square test and Student′s t test. In all the above tests, P < 0.05 was accepted as statistically significant. Results: The positive ratio of Bcl-2 was 85% (17/20 in ameloblastoma, 85% (17/20 in KCOT and 100% (3/3 in lymphomas. Bcl-2 was expressed in peripheral cells and few scattered cells of stellate reticulum in ameloblastoma. KCOT showed strong positivity for Bcl-2 mainly in the basal layer. Interpretation and Conclusion: The present study demonstrates the aggressive nature of KCOT and intrinsic growth potential of its lining epithelium. This study clearly demonstrates that KCOT like ameloblastoma demonstrates aggressive clinical and noticeable invasive behavior. Therefore, it is now considered as no longer a developmental cyst but as odontogenic tumor.

  2. Computed tomographic and magnetic resonance imaging of ameloblastoma: 2 case reports

    Energy Technology Data Exchange (ETDEWEB)

    Oder, P.; Royster, A. [Boston Medical Center, Dept. of Radiology, Boston, Massachusetts (United States); Gibbons, D. [Boston Medical Center, Dept. of Pathology, Boston, Massachusetts (United States); Mulligan, N.; Kavanagh, P.; Eustace, S. [Boston Medical Center, Dept. of Radiology, Boston, Massachusetts (United States)

    1999-12-01

    Cysts of the mandible are uncommon. Most arise from epithelium lining the alveolus or root of the tooth (tooth derivatives), and the rest arise from the cortical and cancellous osseous matrix of the mandible. Of cysts arising from the alveolus (odontogenic epithelium), radicular cysts are the most common, accounting for almost 90% of cases. They are almost always found either in association with a dental cavity or at the base of a devitalized, amalgam-filled tooth. Of the remaining 10% of cases, most are dentigerous cysts, arising from the outer epithelial lining of the developing tooth, which is displaced to the base of the cyst as the lesion grows. Ameloblastoma, which also arises from odontogenic epithelium, accounts for less than 1% of cases. In this case report, we review the imaging appearance, histology and management of this uncommon tumour. In doing so, we highlight signal characteristics on magnetic resonance imaging (MRI) that may allow noninvasive characterization of ameloblastoma before surgical resection. (author)

  3. An Immunohistochemical Survey to Evaluate the Expression of CD105 and CD34 in Ameloblastoma and Odontogenic Keratocyst

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    Shokoofeh Jamshidi

    2014-12-01

    Full Text Available Statement of the Problem: Ameloblastoma is the most common odontogenic tumor which is slow-growing, locally invasive and exhibit specific biologic be-havior and high recurrence rate. Likewise, odontogenic keratocyst is a develop-mental odontogenic cyst that has a high recurrence rate and aggressive behavior. There are limited studies considering the relationship between the angiogenesis factors and the biologic behavior of these lesions. Purpose: the aim of this study was to evaluate the mean density of vessels in odontogenic keratocysts and ameloblastoma and investigate its possible relationship with biological behavior of these lesions. Materials and Method: In this descriptive-analytic cross-sectional study, 40 cases, comprising 10 odontogenic keratocysts and 30 ameloblastomas (10 plexiform, 10 follicular, and 10 unicystic type were selected and were stained immuno-histochemically with CD34 and CD105. The micro vessel density was assessed and compared in all groups. T- test for the independent samples’ One- way Anova, Wilcoxon test and Tukey tests were adopted for statistical analysis. Results: A statistically significant difference was observed in mean vascular density (MVD between the odontogenic keratocyst and ameloblastoma groups concerning the CD105 and CD34 markers (p= 0.005, p= 0.000, respectively. The MVD was significantly higher in ameloblastomas than odontogenic keratocyst. MVD with CD34 was significantly higher than MVD with CD105 in ameloblastomas (p= 0.00. Conclusion: It can be suggested that angiogenesis might be one of the mecha-nisms that is more possible to contribute the aggressive biological behaviors in ameloblastoma rather than odontogenic keratocyst.

  4. Ameloblastoma: A clinicoradiographic and histopathologic correlation of 11 cases seen in Goa during 2008-2012

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    Nigel R Figueiredo

    2014-01-01

    Full Text Available Objectives: The purpose of this case series was to compare the clinical, radiographic, and histopathologic features of 11 cases of ameloblastoma that reported to the Goa Dental College and Hospital over a period of 4 years from January 2008 to December 2012. Study Design: Data with respect to the patients′ ages, sex, location of lesions, radiographic features, histopathologic features and surgical treatment and follow-up, was analyzed. Results: The mean age in males was 23.25 ± 6.99 years, while that in females was 43.43 ± 17.13 years. Seven (63.63% of the 11 subjects were females, and four (36.36% were males. 10 (90.9% of the 11 ameloblastomas were located in the mandible. Swelling was noted in all 11 patients. 10 cases showed radiographic findings, while one case was a peripheral soft-tissue variant. Seven (70% of the 10 tumors were multilocular with a well-demarcated corticated border, and three cases (30% were unilocular. Two cases showed a soap-bubble appearance. Histologically, five cases were unicystic, four were multicystic, one was desmoplastic and one was a peripheral variant. Follow-up ranged from 12 to 34 months and there were no signs of recurrence in any of the patients. Conclusions: Ameloblastomas more commonly occur in females at an older age, as compared with males. Radiographic features that could help in diagnosing ameloblastomas include its predominant occurrence in the mandible, multilocular radiolucency with well-defined, corticated, scalloped margins, expansion of buccal and lingual cortical plates, root resorption and tooth displacement.

  5. Adenomatoid Odontogenic Tumor (AOT) Originating in a Unicystic Ameloblastoma: A Case Report

    OpenAIRE

    Jivan, Vibha; Altini, Mario; Meer, Shabnum; Mahomed, Farzana

    2007-01-01

    The follicular variant of the adenomatoid odontogenic tumor (AOT) is thought to originate from the reduced enamel epithelium of the dental follicle. The origin of the extra-follicular variant however, remains less clear. This paper presents a case of an extra-follicular AOT, which we believe originated from the epithelial lining of a unicystic ameloblastoma, and reviews the literature. The available evidence seems to indicate that some extra-follicular AOTs might arise as secondary phenomena ...

  6. Study of immunohistochemical demonstration of Bcl-2 protein in ameloblastoma and keratocystic odontogenic tumor

    OpenAIRE

    C S Sindura; Chaitanya Babu; Vijaya Mysorekar; Vinod Kumar

    2013-01-01

    Background: The Bcl-2 (B-cell lymphoma) gene product also known as apoptotic inhibitor is expressed in many normal and tumor tissues. This Bcl-2 gene protects the cell by blocking postmitotic differentiation from apoptosis, thus maintaining the stem cell pool. Objective: To study the expression of Bcl-2 protein in ameloblastoma and keratocystic odontogenic tumor (KCOT) to determine their apoptotic behaviors and to analyze biological nature of KCOT, which has higher proliferative potential and...

  7. Ameloblastoma after surgical removal of an impacted mandibular molar. A case report.

    Science.gov (United States)

    Chindia, M L; Guthua, S W; Mwaniki, D L

    1991-04-01

    A case of an ameloblastoma diagnosed about 3 1/2 years after removal of an impacted mandibular 3rd molar is presented. The pre-operative radiographs, though poor in quality, showed an ill-defined radiolucency in relation to the tooth. This feature was not apparent to the examiners at the time of first presentation. Despite unfavourable working conditions in developing countries, a high level of suspicion should be maintained to avoid serious sequelae at a later stage. PMID:2051052

  8. Glandular odontogenic cyst associated with ameloblastoma occupying maxillary sinus: A rare case report

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    Riaz Abdulla

    2016-01-01

    Full Text Available The glandular odontogenic cyst (GOC is a rare entity with around 111 cases available in the literature. The occurrence of GOC with ameloblastoma as a collision tumor is rarest, and such a case poses problems in the form of diagnostic dilemma and management. The present case report describes and discusses a rare case of GOC with ameloblastomatous component occurring in right maxilla of a 54-year-old male patient with a chief complaint of painful swelling.

  9. Diagnostic ability of differential diagnosis in ameloblastoma and odontogenic keratocyst by imaging modalities and observers

    International Nuclear Information System (INIS)

    To evaluate the diagnostic ability in differentiating between ameloblastoma and odontogenic keratocyst according to the imaging modalities and observes. We evaluated thirty-six cases of ameloblastomas and forty-seven cases of odontogenic keratocysts all histologically confirmed. Six oral and maxillofacial radiologists diagnosed the lesions by 3 methods: using panoramic radiograph, using computed tomograph (CT), and using panoramic radiograph and CT. The observers were classified by 3 groups: group 1 had experienced over 10 years in oral and mazilofacial radiologic field, group 2 had experienced for 3-4 years, and group 3 was in the process of residentship. After over 2 weeks, the observers diagnosed them by the same methods. The ROC curve areas except for group 3 were the highest with interpretation using panoramic radiograph and CT, followed by interpretation using CT only, and the lowest with interpretation using panoramic radiograph only. The overall difference was not found in diagnostic ability among groups in using panoramic radiograph only, but there was difference in diagnostic ability of group 1 and 2 vs 3 in using CT only, and combination panoramic radiograph and CT. To differentiate between ameloblastoma and odontogenic keratocyst more accurately, the experienced oral and maxillofacial radiologist should diagnose with combination of panoramic radiograph and CT

  10. Potential value and disadvantages of fine needle aspiration cytology in diagnosis of ameloblastoma.

    Science.gov (United States)

    Perić, Marija; Milicić, Valerija; Pajtler, Marija; Marjanović, Ksenija; Zubcić, Vedran

    2012-11-01

    Ameloblastoma is a benign, slow growing but locally aggressive tumor that is clinically manifested as swelling in a jaws. Prone to relapse (30%) even 30 years after inadequate primary operation. The most important cytological features of this tumor are small bazaloid cells in clusters, and single spindle and stellate shaped cells. We report on a case of 79-year-old patient, who was hospitalized due to tumor formation in the buccal region. FNA was performed and liquid material that contained only fagocites was collected. The conclusion was--cyst, while biopsy finding--adenoma baseo-cellulare, pointed to the salivary gland tumor. Patient refused the proposed surgical treatment. Four years later, the patient was urgently hospitalized due heavy bleeding from the tumor in the same region. It affected the crest portion of the upper jaw and a section of hard palate, and was bleeding on palpation. In second FNA we found phagocytes and a few small clusters of basaloid cells with palisade arrangement at the edges. Because of uniform and benign cytomorphological features it was concluded that it was a cystic tumor. On biopsy pattern the diagnose of ameloblastoma was determinated. The patient underwent surgery, however due to postoperative complications he died. Preoperative diagnosis is usually set on the basis of clinical and often nonspecific radiological findings. As it is very important to get the correct diagnose before planning an adequate surgical procedure, we would like to point out the potential value and disadvantages of FNA cytology in the diagnosis of ameloblastoma. PMID:23397775

  11. Análise imuno-histoquímica das citoqueratinas em ameloblastoma e tumor odontogênico adenomatóide Immunohistochemical analysis of cytokeratins in ameloblastoma and adenomatoid odontogenic tumor

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    Fernanda Ferreira Lopes

    2005-12-01

    Full Text Available OBJETIVO: O presente trabalho teve por objetivo traçar o perfil das citoqueratinas (CKs 7, 8, 10, 13, 14, 18 e 19 em ameloblastomas e tumor odontogênico adenomatóide (TOA visando contribuir para o entendimento da histogênese desses tumores e somar com os resultados já relatados na literatura. MATERIAL E MÉTODO: do arquivo do Laboratório de Anatomia Patológica do Departamento de Odontologia da Universidade Federal do Rio Grande do Norte (UFRN foi selecionada uma amostra com dez casos de ameloblastomas e oito de TOA para o estudo imuno-histoquímico, utilizando-se anticorpos anti-CKs pelo método da estreptoavidina-biotina. RESULTADOS: Observou-se que nos ameloblastomas a CK 14 esteve presente em todos os casos, enquanto a CK 19 foi observada nas células periféricas (oito casos e nas centrais (cinco casos. Para os TOA, observou-se imunopositividade para a CK 14 em todos os casos, enquanto a CK 19 esteve marcada predominantemente nas células ductais (seis casos. CONCLUSÃO: As citoqueratinas são expressas de forma variada nos ameloblastomas e nos TOA, os quais preservam CK típicas do germe dental em estágios avançados do desenvolvimento, confirmando sua origem exclusiva a partir do epitélio odontogênico e não se evidenciando CK características do epitélio escamoso.OBJECTIVES: The aim of the present study was to describe the immunohistochemical expression of cytokeratins (CKs 7, 8, 10,13, 14, 18 and 19 in the epithelial components of ameloblastomas and adenomatoid odontogenic tumor (AOT. The results were compared and histogenesis discussed. MATERIAL AND METHOD: Specimens of ten ameloblastomas and eight adenomatoid odontogenic tumors were examined by immunohistochemistry using streptavidin-biotin-peroxidase complex method and anti-CKs antibody. The sample was obtained from Department of Oral Pathology, Federal University of Rio Grande do Norte. RESULTS: Immunohistochemical reactivity for CK14 was detected in all cases of

  12. Ameloblastoma uniquístico, bases del tratamiento conservador: Presentación de caso clínico y actualización bibliográfica Single cyst ameloblastoma, basis of conservative treatment: Presentation of a clinical case and update of the literature

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    J. Argandoña Pozo

    2010-06-01

    Full Text Available El ameloblastoma se define como un tumor localmente agresivo e infiltrante, con una alta capacidad de recidiva. Este comportamiento agresivo e infiltrante plantea la problemática de una opción conservadora o radical de tratamiento, con las alteraciones funcionales, estéticas y psicológicas que esta última alternativa implica. El ameloblastoma uniquístico se describe como una lesión con cuadros morfológicos particulares, un comportamiento biológico menos agresivo que el ameloblastoma común, y una menor recurrencia frente a la terapia conservadora. Se presenta un caso clínico con el diagnóstico de ameloblastoma uniquístico tratado de forma conservadora mediante descompresión y posterior enucleación. Se actualiza la información sobre su tratamiento.The ameloblastoma it's defined as a localy aggressive neoplasm with a high incidence to local recurrence. This aggressive behaviour gives two options: a conservative treatment or a radical one, with all the functional, aesthetic and psychological alterations this implies. The unicyst ameloblastoma it's described as a disease with particular morphological aspects, a less aggressive biological behaviour than the common ameloblastoma, and less chances to reappear after a conservative treatment. Here we present a case of unicyst ameloblastoma treated in a conservative way by decompresion and resection. A review of the actual treatment methods.

  13. Ameloblastoma plexiforme del maxilar: manejo quirúrgico y protético. A propósito de un caso Plexiform ameloblastoma in the maxilla: surgical and prosthetic management. With reference to one case

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    F Carini

    2007-02-01

    Full Text Available El ameloblastoma es un tumor odontógeno benigno de derivación epitelial, de elevada invasión local, crecimiento intermitente y con alta probabilidad de recidiva. Puede dividirse en los siguientes tipos histológicos: folicular, plexiforme, acantomatoso, a células basales y granulares. El ameloblastoma folicular es el subtipo histológico más común. Se manifiesta prevalentemente durante la tercera, cuarta y quinta década de vida, sin predilección para el sexo, aun así se puede encontrar en cualquier grupo de edad incluyendo niños. La mayoría de los ameloblastomas se encuentra sobretodo en mandíbula (al nivel del ángulo y rama. Las características clínicas, incluso si complementadas con radiografías y muestras histológicas, no son útiles a la hora de predeterminar el comportamiento biológico y por lo tanto el pronóstico de un ameloblastoma individual. Los autores presentan un caso localizado de ameloblastoma plexiforme localizado en la parte posterior del maxilar de un hombre de 30 años; el término "plexiforme" se refiere al aspecto de anastomosis de los islotes del epitelio odontógeno, en contraste con el tipo «folicular». En este artículo se discuten importantes aspectos de la patología, del tratamiento quirúrgico y protésico. En conclusión, es necesaria una cooperación estricta a largo plazo de un grupo de clínicos, patólogos, cirujanos y prostodoncistas, para ofrecer el mejor tratamiento individualizado en cada caso.The ameloblastoma is a clinically persistent benign tumor derived from odontogenic epithelium, locally invasive, intermittent in growth and with high a probability of recurrence. The following histologic patterns may be distinguished: follicular, plexiform, spindle cell, acanthomatous, basal cell type and granular cell. The follicular ameloblastoma is the most common histologic tipe. The majority of patients are in 3th, 4th and 5th decade, but can be found in any age group including children. The

  14. Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

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    Shubhagata Das

    2013-08-01

    Full Text Available A 6 year old female Spitz dog was admitted to Teaching Veterinary Hospital at Chittagong Veterinary and Animal Sciences University with the history of inappetance and asymmetric lower jaw. Oral inspection revealed a pair of pale enlarged lobulated mass around the third molar tooth of the left mandible. The dog was clinically diagnosed with epulis and successfully cured by surgical excision. Histopathological section of the excised masses revealed characteristic features of acanthomatous ameloblastoma with some atypical lesions. Multifocal areas of ameloblastic islands were found in the dense sheet of proliferating epithelial layer protruding towards the sub epithelial connective tissue stroma. These islands were characterized with irregular epithelial stratification at the basal layer. Besides, presence of ghost cells was the unusual findings for such case. Prominent intercellular bridging and nuclear polymorphism in odontogenic cells were other decisive characters of the lesion. Based on the histomorphological appearance, the gingival tumor was designated as canine acanthomatous ameloblastoma (CAA with atypical histomorphology. [Vet World 2013; 6(4.000: 219-222

  15. Distraction osteogenesis of free flap reconstructed mandible following ameloblastoma resection for optimal functional rehabilitation.

    Science.gov (United States)

    Bousdras, V A; Kalavrezos, N

    2014-01-01

    This case highlights the use of a custom-made distractor (Synthes GmbH, Oberdorf, Switzerland), used to increase bone height prior to rehabilitation with implant placement, in a patient following excision of an ameloblastoma and reconstruction of her mandible with a fibular flap. A 27-year-old patient had her mandible reconstructed following wide resection of an ameloblastoma. Although a 2.0 LOCK reconstruction plate (Synthes GmbH, Oberdorf, Switzerland) was used for fixation of the fibular bone, the vertical deficiency between the reconstructed segment and the occlusal plane made oral rehabilitation impossible. To overcome this, the fibular bone segment was vertically distracted following a latency period of 4 days. Distractor was left in place for 20 weeks for bone consolidation. Following device removal implants were placed. The novelty of this approach included fixation of the lower arm of the distractor on the LOCK plate. The distractor was unidirectional with two arms of different length. The lower arm composed of a 2.0 mini-plate to fit exactly on the 2.0 LOCK plate whereas the upper arm used a standard 1.5 mini-plate. Advantages of this custom-made distractor included: (i) No need for removal of the reconstruction plate, (ii) no need for an extraoral surgical approach, and (iii) no need for additional drilling to fit the lower arm of the distractor. Technical details and limitations are presented. PMID:25593885

  16. Report of Two Cases of Combined Odontogenic Tumors: Ameloblastoma with Odontogenic Keratocyst and Ameloblastic Fibroma with Calcifying Odontogenic Cyst.

    Science.gov (United States)

    Neuman, Ashley Nicole; Montague, Lindsay; Cohen, Donald; Islam, Nadim; Bhattacharyya, Indraneel

    2015-09-01

    Combined odontogenic neoplasms have rarely been documented. Such tumors have also been described by other researchers as "hybrid" lesions. The histologic features are often identical to other individually well-established odontogenic neoplasms such as ameloblastoma, adenomatoid odontogenic tumor, ameloblastic fibroma (AF), and ameloblastic fibro-odontoma. Their clinical presentation is variable, ranging from cysts to neoplasms showing varying degrees of aggressive behavior. Most combined tumors contain features of one of the odontogenic tumors in combination with either a calcifying odontogenic cyst (COC) or a calcifying epithelial odontogenic tumor. We present two new cases of combined odontogenic tumors: an ameloblastoma with an odontogenic keratocyst and an AF with COC. Predicting clinical outcome is challenging when a combination tumor is encountered due to the paucity of such lesions. One must understand salient features of these entities and differentiate them from the more common conventional neoplasms to expand classification and provide prognostic criteria. PMID:25552434

  17. Glandular odontogenic cyst mimicking ameloblastoma in a 78 year old female: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do; Lee, Wan; Kwon, Kyung Hwan; Choi, Moon Ki; Choi, Eun Joo [College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Yoon, Jung Hoon [Dept. of Oral and Maxillofacial Pathology, College of Dentistry, Daejeon Dental Hospital, Wonkwang University, Daejeon (Korea, Republic of)

    2014-09-15

    Glandular odontogenic cyst (GOC) is a rare, potentially aggressive jaw lesion. The common radiographic features include a well-defined radiolucency with distinct borders, presenting a uni- or multilocular appearance. A cystic lesion in the posterior mandible of a 78-year-old female was incidentally found. Radiographs showed a unilocular lesion with a scalloped margin, external root resorption of the adjacent tooth, and cortical perforation. This lesion had changed from a small ovoid shape to a more expanded lesion in a period of four years. The small lesion showed unilocularity with a smooth margin and a well-defined border, but the expanded lesion produced cortical perforation and a lobulated margin. The provisional diagnosis was an ameloblastoma, whereas the histopathological examination revealed a GOC. This was a quite rare case, given that this radiographic change was observed in the posterior mandible of an elderly female. This case showed that a GOC can grow even in people in their seventies, changing from the unilocular form to an expanded, lobulated lesion. Here, we report a case of GOC with characteristic radiographic features.

  18. Genomic organization and localization of mouse Nma/BAMBI: possible implications related to ameloblastoma formation.

    Science.gov (United States)

    Knight, C; Papagerakis, P; Simmons, D; Berdal, A; MacDougall, M

    2002-01-01

    Our laboratory has determined the DNA sequence and transcriptional expression pattern of a mouse cDNA clone termed Nma/BAMBI. This clone encodes a highly conserved protein with 89% identity to the human homologue (termed Nma) and 78% similarity to the Xenopus homologue (termed BAMBI) at the predicted amino acid level. Nma/BAMBI encodes a 260-amino-acid transmembrane protein that has homology to the transforming growth factor (TGF) beta type I receptor family. This protein contains an extracellular ligand binding domain, a 24-amino-acid transmembrane domain, and a short intracellular domain that lacks a functional serine/threonine kinase domain. It is believed that Nma/BAMBI is important in the negative regulation of TGF beta signal transduction pathways during development and has implications in tumor progression. We have determined the genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2. Furthermore, we report the production and utilization of an anti-peptide antibody in preliminary immunohistochemical analysis of an ameloblastoma. PMID:12489181

  19. Enriched vascularity in ameloblastomas, an indeterminate entity: Report of two cases

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    Usha Hegde

    2015-01-01

    Full Text Available Vascularity is a highly essential element that is required for the growth, development, and functioning of the body and variations in it can cause pathologies. It is one of the prime features of a proliferating lesion, where it aids in the growth of the lesion through its nutrition supply. Highly increased vascularity in a disease can itself affect the prognosis of the lesion, and in malignancies, it can induce tumor seeding and secondaries. Most of the pathologies including tumors, related to blood vessels, and vascularity are well established. There are some conditions, wherein altered vascularity is one of the prime components along with other diagnostic components of an established disease. In such cases, these lesions are diagnosed with special names, with varying biological behavior and prognosis in comparison to that of established entity. However, there still are few similar conditions whose nature is uncertain due to the rarity of the lesion and the insufficient scientific evidence which eludes the diagnostician. Here is the report of two cases of ameloblastoma, an established entity, with significant vascularity whose nature is indeterminate.

  20. Le Fort I osteotomy for the removal of a rare unicystic ameloblastoma lesion in the maxillary sinus.

    Science.gov (United States)

    Iwaki, Lilian Cristina Vessoni; Tolentino, Elen Souza; Lustosa, Rômulo Maciel; Jacomacci, Willian Pecin; Casaroto, Ana Regina; Leite, Pablo Cornelius; Iwaki-Filho, Liogi

    2016-01-01

    The unicystic ameloblastoma (UA) presents the clinical and radiographic characteristics of a maxillary cyst, making early diagnosis difficult. A 30-year-old man had an extensive, asymptomatic lesion in the right maxillary sinus. Radiographic examinations demonstrated a retained tooth in association with a lesion. Histopathologic examination revealed the presence of UA with intraluminal and mural infiltration and a follicular pattern. Le Fort I access was chosen for enucleation of the lesion and curettage of the site, which were followed by cryotherapy. The treatment provided adequate intraoperative visibility, enabled the preservation of the surrounding bone, and eliminated postoperative complications. Follow-up over 5 years demonstrated no recurrence. PMID:27148651

  1. GMP-level adipose stem cells combined with computer-aided manufacturing to reconstruct mandibular ameloblastoma resection defects: Experience with three cases

    OpenAIRE

    Wolff, Jan; Sándor, George K.; Miettinen, Aimo; Tuovinen, Veikko J.; Mannerström, Bettina; Patrikoski, Mimmi; Miettinen, Susanna

    2013-01-01

    Background: The current management of large mandibular resection defects involves harvesting of autogenous bone grafts and repeated bending of generic reconstruction plates. However, the major disadvantage of harvesting large autogenous bone grafts is donor site morbidity and the major drawback of repeated reconstruction plate bending is plate fracture and difficulty in reproducing complex facial contours. The aim of this study was to describe reconstruction of three mandibular ameloblastoma ...

  2. Evaluation of the Nature of Collagen Fibers in KCOT, Dentigerous Cyst and Ameloblastoma using Picrosirius Red Stain – A Comparative Study

    Science.gov (United States)

    Sekhar, Manne Srinivas Muni; Shylaja, Sanjeevareddygari; Bhavani, Sangala Nagendra; Ramanand, Oruganti Venkata; Patha, Spandana; Reddy, Sharath Kumar; Rani, Akula Sandhya

    2015-01-01

    Background Reciprocal interaction between dental epithelium and mesenchyme is thought to be crucial for normal odontogenesis. Thus, the mesenchymal influence of the fibrous capsules may play an important role in the maintenance of epithelial expression. Collagen is the major component of the extracellular matrix and possibly there is an alteration in the nature and structure of collagen in various pathological conditions. Studies by polarizing microscopy have also shown that there is a difference in collagen and probably these differences may play a role in their biologic behaviour. Aim The purpose of this study was to evaluate the nature of collagen fibers in keratocystic odontogenic tumour (KCOT), dentigerous cyst (DC), unicystic ameloblastoma (UA) and solid/multicystic ameloblastoma (SMA) and correlating this with their biological behaviour. Materials and Methods Five diagnosed cases each of UA, SMA, KCOT and DC were taken and stained using Picrosirius red stain kit and evaluated using a polarizing microscope. Statistical Analysis Chi-square test was used to analyse the results. Results and Conclusion Collagen fibers in dentigerous cysts showed predominant yellowish-red birefringence and fibers in KCOT and ameloblastomas showed a predominantly greenish-yellow birefringence. Hence, our study suggests that the nature and character of collagen fibers may influence the clinical behaviour of the lesion. Since ours is a pilot study, to corroborate our view, studies with larger sample size are required to substantiate the results. PMID:26673081

  3. Educational effect of a lecture on differential imaging features comparing ameloblastomas and keratocystic odontogenic tumors of the mandible presented to dental students

    International Nuclear Information System (INIS)

    The objective of this study was to clarify the educational effect of a lecture on differential imaging features comparing ameloblastomas and keratocystic odontogenic tumors of the mandibles presented to dental students. Panoramic and CT images of 10 ameloblastomas and 10 keratocystic odontogenic tumors were randomly presented 114 dental students. Test scores, correct answer ratios, identification index, and understanding of the imaging features contributing to a correct diagnosis were serially evaluated before and after the lecture on the differential imaging features comparing the two types of tumors. The mean and standard deviation of the scoring ratios of dental students diagnosing these lesions on panoramic and CT images were 48.8±10.8% and 52.5±12.9%, respectively. After the lecture on the differential imaging features comparing the two tumors, the scoring ratios improved significantly. After the lecture, both the numbers of patients whose images were correctly diagnosed and the identification indices increased. The lecture also increased the number of imaging features recognized as contributing to the correct diagnosis. A lecture on the differential imaging features comparing ameloblastomas and keratocystic odontogenic tumors of the mandibles contributed to the improvement of imaging diagnosis skills among dental students. (author)

  4. Spontaneous multi-cystic peripheral ameloblastoma in the freshwater angelfish, from the Brazilian state of Pará

    Directory of Open Access Journals (Sweden)

    M. Videira

    2015-08-01

    Full Text Available Este trabalho registra a ocorrência espontânea de ameloblastoma em P. scalare. O tumor foi obtido a partir de um exemplar de Acará Bandeira, sendo fixado, seccionado, e os fragmentos processados para microscopia de luz e microscopia eletrônica de varredura (MEV. O exame macroscópico evidenciou uma massa tumoral que se estendia do rebordo alveolar do maxilar superior à face externa labial. À MEV, a neoplasia apresentou uma série de espículas. Microscopicamente, percebia-se um processo neoplásico constituído por tecido conjuntivo de característica mixoide, ricamente vascularizado, onde eram observados fragmentos de tecido osteoide. A amostra revelou proliferação neoplásica do epitélio odontogênico, onde as células neoplásicas se organizavam na forma de paliçada. Alterações histopatológicas em peixes têm sido úteis biomarcadores do efeito à exposição a substâncias tóxicas, sendo as neoplasias lesões específicas, comumente encontradas em peixes de áreas poluídas, revelando uma associação entre as lesões e a exposição a irritantes.

  5. Regeneration of mandibular ameloblastoma defect with the help of autologous dental pulp stem cells and buccal pad of fat stromal vascular fraction.

    Science.gov (United States)

    Manimaran, K; Sharma, Rohini; Sankaranarayanan, S; Perumal, S Mahendra

    2016-01-01

    Ameloblastoma is benign odontogenic tumor, which is locally aggressive in behavior. Till date, the treatment of choice is resection and reconstruction using a variety of modalities. Inadequate resection may lead to many complications such as bone deformity and dysfunction. This report is about a 14-year-old male with ameloblastoma treated with autologous dental pulp stem cells (DPSCs) and stromal vascular fraction (SVF) and evidence of bone regeneration. Marsupialization was performed; tooth was extracted and sent for DPSC cultivation. On the day of surgery, SVF was processed from buccal pad of fat, and platelet-rich fibrin (PRF) was prepared from patient's peripheral blood. During the procedure, labial plate resection and curating of tumor lining were done. After which, a mesh packed with SyboGraft T-plug, prepared SVF, DPSCs, and PRF were placed over lingual cortex and pressure dressing was done. After the 1(st) month of surgery the postoperative course was uneventful, the wound shrinkage led to exposure of mesh in the intraoral region. Removal of exposed mesh was done. The correction surgery with removal of part of mesh and primary closure was achieved with SyboGraft plug, SVF and PRF. Enhanced bone formation was seen in post-operative OPG and CT Scan after 10(th) month. In this article, we propose an innovative approach to manage these cases by using a combination of autologous DPSC and buccal pad of fat SVF to regenerate a mandibular defect left by the resection of an ameloblastoma with 1.5 year follow-up. We were able to demonstrate bone regeneration using this technique with no recurrence of tumor. PMID:27563616

  6. Relation of the radiologic findings and labeling index of Ki-67, PCNA and cytokeratin in unicystic ameloblastoma, dentigerous cyst and odontogenic keratocyst

    International Nuclear Information System (INIS)

    To compare the proliferation potential of the epithelial cells between unicystic ameloblastoma (UA), dentigerous cyst (DC), and odontogenic keratocyst (OKC) and to correlate this proliferation potential with the radiographic features of these three pathoses. Immunohistochemical expression of PCNA, Ki-67, and cytokeratin as a proliferation maker were assessed for 15 cases of UA, 15 cases of DC, and 15 cases of OKC. The degree of immunochemical expression of three proliferation markers were correlated with the radiographic features, especially cortical expansion (negative and positive) and shape of border (scalloped and round). Using PCNA and Ki-67, OKC showed the highest proliferation potential and UA the lowest. Statistically significant differences were found between the OKC and the UA (p<0.05). However, no statistically significant difference was present according to the radiographic features in all pathoses. Using cytokeratin, there was no significant differences of proliferation potential among three pathoses. OKC epithelium has the most intense proliferation potential, followed by the dentigeous cyst and then unicystic ameloblastoma. There is no significant relation between the radiographic features and the proliferation potential of epithelium of these three pathoses.

  7. 钛髁突假体修复造釉细胞瘤切除术后颌骨缺损的临床初步研究%A clinical preliminary syudy of mandible defects caused by resection of ameloblastoma and repaired with tita-nium condylar prosthesis

    Institute of Scientific and Technical Information of China (English)

    张新凤; 董智伟; 鲍海宏; 张力

    2015-01-01

    Objective:to investigate the clinical effect of the titanium condylar prosthesis in repairing mandibular de-fects caused by resection of ameloblastoma. Method:12 patients with mandibular defect caused by resection of ameloblas-toma and condylar.The defects were repaired with a titanium condylar prosthesis mandibular. The appearance of face,maxi-mal incisal opening,wound healing process,occluding relation and titanium plate retention was recorded. Result:the appear-ance of face was satisfactory 11 patients and slight deformity of face was observed in 1 patients. In maximal incisal opening (MIO),no significant difference was found between preoperative and postoperative. All of these patients healed by first in-tention. The occluding relation was recovered well,and one plate fractured was delayed for one year. Conclusion:titanium condylar prosthesis can be used as a safe and effective method in repairing mandibular defects caused by resection of ameloblastoma.%目的:观察应用带髁突假体的钛板即刻修复下颌骨造釉细胞瘤术后颌骨缺损的治疗效果。方法:12例下颌骨造釉细胞瘤患者,行髁突切除术后,即刻植入带髁突的假体。记录面部外形、开口度、创口愈合情况、咬合关系及钛板固位情况。结果:11例患者对面部外形恢复满意,1例对面型恢复不满意,术前术后开口度无显著差异(P>0.05),上下颌牙咬合关系恢复良好,1例钛板术后1年发生断裂。结论:钛髁突假体行造釉细胞瘤术后颌骨缺损的修复是一种安全有效的方法。

  8. Critical Role of Heparin Binding Domains of Ameloblastin for Dental Epithelium Cell Adhesion and Ameloblastoma Proliferation*

    OpenAIRE

    Sonoda, Akira; Iwamoto, Tsutomu; Nakamura, Takashi; Fukumoto, Emiko; Yoshizaki, Keigo; Yamada, Aya; Arakaki, Makiko; Harada, Hidemitsu; Nonaka, Kazuaki; Nakamura, Seiji; Yamada, Yoshihiko; Fukumoto, Satoshi

    2009-01-01

    AMBN (ameloblastin) is an enamel matrix protein that regulates cell adhesion, proliferation, and differentiation of ameloblasts. In AMBN-deficient mice, ameloblasts are detached from the enamel matrix, continue to proliferate, and form a multiple cell layer; often, odontogenic tumors develop in the maxilla with age. However, the mechanism of AMBN functions in these biological processes remains unclear. By using recombinant AMBN proteins, we found that AMBN had heparin binding domains at the C...

  9. Giant acanthomatous epithelial tumor of the mandible: A rare entity

    Directory of Open Access Journals (Sweden)

    Amit Mittal

    2015-01-01

    Full Text Available Ameloblastoma is a rare benign odontogenic tumor which arises from the odontogenic epithelium. It usually exhibits a range of histopathologic features, such as follicular, plexiform, acanthomatous, granular, basal cell, and desmoplastic variants, which are well recognized. This study reports a case of giant acanthotic ameloblastoma that developed at the anterior mandible in a 70-year-old male. Radiologically, it was diagnosed as ameloblastoma, benign tumor of the jaw which is rare. Biopsy was taken intra-orally, it was confirmed as acanthomatous ameloblastoma. When extensive squamous metaplasia, often associated with keratin formation occurs in central portions of the epithelial islands of follicular ameloblastoma, the term acanthomatous is sometimes applied.

  10. Keratoameloblastoma: Report of a rare variant with review of literature

    Directory of Open Access Journals (Sweden)

    Vineet Raj

    2014-01-01

    Full Text Available Ameloblastoma has intrigued clinicians as well as pathologists due to its diverse clinical behavior and histomorphologic presentations. Keratoameloblastoma is a rare histologic sub type, characterized by extensive keratin formation within ameloblastic epithelium, with only a handful number of cases described in the literature. Here, we report a case of this uncommon sub type of ameloblastoma in a young female patient presenting as an extensive lesion in mandibular ramus area. The radiological and fine needle aspiration findings suggested of a keratinizing cystic lesion and incisional biopsy showed features of ameloblastoma. Patient underwent segmental mandibulectomy and histological examination of excisional specimen revealed features of ameloblastoma with abundant keratinization leading to a diagnosis of keratoameloblastoma. The diagnostic pitfalls related with the lesion have been discussed along with a short review of the literature.

  11. Msx and Dlx Homeogene Expression in Epithelial Odontogenic Tumors

    OpenAIRE

    Ruhin-Poncet, Blandine; Ghoul-Mazgar, Sonia; Hotton, Dominique; Capron, Frédérique; Jaafoura, Mohamed Habib; Goubin, Gérard; Berdal, Ariane

    2009-01-01

    Epithelial odontogenic tumors are rare jaw pathologies that raise clinical diagnosis and prognosis dilemmas notably between ameloblastomas and clear cell odontogenic carcinomas (CCOCs). In line with previous studies, the molecular determinants of tooth development—amelogenin, Msx1, Msx2, Dlx2, Dlx3, Bmp2, and Bmp4—were analyzed by RT-PCR, ISH, and immunolabeling in 12 recurrent ameloblastomas and in one case of CCOC. Although Msx1 expression imitates normal cell differentiation in these tumor...

  12. 下顎に発生したエナメル上皮腫の1症例 : Runx2の免疫組織化学的検討

    OpenAIRE

    杉野, 紀幸; 村木, 英司; 清水, 貴子; 塩島, 勝; 川上, 敏行

    2006-01-01

    A case of ameloblastoma in a 67-year-old male Malay patient was described with immunohistochemical examination of Runx2. After histopathological examination and diagnosis, the immunohistochemical expression of transcription factor Runx2 was examined. Histopathologically, the tumor consisted predominantly of proliferating follicular nests of odontogenic epithelial cells randomly disposed in the fibrous tissue. Some of these ameloblastoma cell nests showed features of central cystic degeneratio...

  13. Dentinoameloblastoma with ghost cells: A rare case report with emphasis on its biological behavior

    Directory of Open Access Journals (Sweden)

    Kiran Kumar

    2013-01-01

    Full Text Available Ameloblastomas are regarded as a homogeneous group of neoplasms with locally invasive character. They generally do not show induction of dental hard tissue formation except in few cases. Biological behavior and histogenesis of these tumors is still unexplored as there is lack of relevant studies and long follow-up of these patients. So, we aimed to report this rare case of dentinoameloblastoma with unique presence of ghost cells in middle-aged female involving maxilla with emphasis on its biological behavior. We conclude that although histogenesis of this tumor is not clear but biological potential is similar to conventional ameloblastoma requiring wider excision.

  14. Adolescent Mandibular Central Odontoameloblastoma: A Rare Case Report.

    Science.gov (United States)

    Arun Kumar, K V; Mowar, Apoorva; Gupta, Rajat; Deepa, D

    2016-03-01

    Odontoameloblastoma is a rare odontogenic tumour, characterised by simultaneous occurrence of an ameloblastoma and a compound or complex odontoma in the same tumoral mass. The tumour is seen in first three decades and affects mandible or maxilla equally, commonly found posterior to the canines. The management is similar to unicystic ameloblastoma and odontoma excision. A long term follow up is a must to observe the recurrence. Here we present a rare case of odontoameloblastoma in a 17 year old male, presenting as an asymptomatic anterior mandibular swelling with chief complaint of missing lower front teeth. PMID:26929561

  15. Pediatric Odontogenic Tumors.

    Science.gov (United States)

    Abrahams, Joshua M; McClure, Shawn A

    2016-02-01

    Pediatric odontogenic tumors are rare, and are often associated with impacted teeth. Although they can develop anywhere in the jaws, odontogenic tumors mainly occur in the posterior mandible. This article discusses the diagnosis and treatment of the most common pediatric odontogenic tumors, such as ameloblastoma, keratocystic odontogenic tumor, odontoma, and cementoblastoma. PMID:26614700

  16. Ameloblastic carcinoma: Secondary dedifferentiated carcinoma of the mandible: Report of a rare entity with a brief review

    Directory of Open Access Journals (Sweden)

    Siddharth Pundir

    2011-01-01

    Full Text Available Epithelial odontogenic tumors arise from odontogenic epithelial structures. Malignant epithelial odontogenic tumors are extremely rare. Ameloblastic carcinomas may present denovo, ex ameloblastoma or ex odontogenic cyst. Most ameloblastic carcinomas are presumed to present denovo. To date less than 45 cases of ameloblastoma with metastasis have been reported. It occurs primarily in the mandible in a wide range of age groups; no sex or race predilection has been noted. It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption, and tooth mobility. The lesion is usually found unexpectedly after an incisional biopsy or the removal of a cyst. Histologic features of ameloblastic carcinoma shows tumor cells that resemble the cells seen in ameloblastoma, but they show cytologic atypia. Moreover, they lack the characteristic arrangement seen in ameloblastoma. The clinical course of ameloblastic carcinoma is typically aggressive, with extensive local destruction. Here we describe a rare case of ameloblastic carcinoma (secondary dedifferentiated carcinoma of mandible in a 40-year-old female patient. Ameloblastic carcinoma: Secondary dedifferentiated carcinoma of the mandible.

  17. Oral tumours seen at Korle Bu Teaching Hospital: a preliminary report

    International Nuclear Information System (INIS)

    Oral tumours in patients attending the oral Surgery Department of the Korle Bu Teaching Hospital, Accra, during a 12 month period from February 1998 to January 1999 were studied and classified. In all, 50 patients were included in the study out of which 33 were fully characterised and classified historically. Fifteen (45.4%) of the tumours examined were squamous cell carcinoma (SCC), 6(18.2%) ameloblastoma (AME), 3 (9.1%) each of Lympoma (L), adenoid cystic carcinoma (ADC) and pleomorphic adenoma (PA), 2(61.1%) ossifying fibroma (OF) and 1(3.0%) embryonal rhabdomyosar coma (ER). There was significant observed between the prevalence rates in men and women. OSCC was found to occur more frequently in the palate/maxillary sinus and the parotid gland whilst ameloblastoma was the commonest benign neoplasm within the fourth decade. (author)

  18. Parameters in panoramic radiography for differentiation of radiolucent lesions

    OpenAIRE

    Ricardo Raitz; José Narciso Rosa Assunção Júnior; Luciana Correa; Marlene Fenyo-Pereira

    2009-01-01

    Objective: The aims of this study were to establish parameters in panoramic radiography for interpretation of unilocular radiolucent lesions, and to compare the accuracy of diagnoses given by examiners before and after using these parameters. Material and Methods: In Part I, 12 specialists analyzed 24 images and the diagnostic criteria used by each examiner to make correct diagnoses were used to build a list of basic radiographic parameters for each pathology (ameloblastoma, keratocystic odon...

  19. Central odontogenic fibroma of the mandible: A case report with diagnostic considerations

    OpenAIRE

    Angela Santoro; Giuseppe Pannone; Luca Ramaglia; Pantaleo Bufo; Lorenzo Lo Muzio; Raffaele Saviano

    2015-01-01

    Introduction: Odontogenic fibroma (OF), a rare odontogenic tumor of mesodermal origin, has been thought to originate from either dental follicle, periodontal ligament, or dental papilla [1]. Different studies reported high variability in the incidence rate as being between 3 and 23% of all odontogenic tumors [2,3]. OF manifests a dual character at the histopathological examination showing odontogenic epithelial structures mimicking those observed in biopsy of ameloblastoma and, in addition, p...

  20. Papilliferous Keratoameloblastoma: An Extremely Rare Case Report

    OpenAIRE

    Satya Ranjan Misra; Susant Mohanty; Neeta Mohanty; Varun Rastogi

    2013-01-01

    Odontogenic tumors develop in the jaw bones from the odontogenic tissue-oral epithelium in tooth germ, enamel organ, dental papilla, reduced enamel epithelium, remnants of Hertwig's root sheath or dental lamina, and so forth. Hence, a bewildering variety of tumors are encountered in the maxilla and mandible. Ameloblastoma is the second most common odontogenic neoplasm after odontomes, and it has numerous clinical and histologic variants. We report a very rare histologic variant: the papillife...

  1. Histopathological insight of complex odontoma associated with a dentigerous cyst

    OpenAIRE

    Astekar, Madhusudan; Manjunatha, Bhari Sharanesha; Kaur, Prabhpreet; Singh, Jappreet

    2014-01-01

    Odontomas and dentigerous cysts are common findings for practicing dental professionals. However, simultaneous occurrence of pathologies like odontoma and dentigerous cyst are uncommon and their diagnosis based on the radiographic appearance alone is a challenge to overcome. They together are a potential for complications like attaining large size, root resorption, destruction of the jaw bones and sometimes neoplastic changes like ameloblastoma. This paper presents a case of complex odontoma ...

  2. FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.

    Science.gov (United States)

    Kuga, Takahisa; Sasaki, Mitsuho; Mikami, Toshinari; Miake, Yasuo; Adachi, Jun; Shimizu, Maiko; Saito, Youhei; Koura, Minako; Takeda, Yasunori; Matsuda, Junichiro; Tomonaga, Takeshi; Nakayama, Yuji

    2016-01-01

    FAM83H is essential for the formation of dental enamel because a mutation in the FAM83H gene causes amelogenesis imperfecta (AI). We previously reported that the overexpression of FAM83H often occurs and disorganizes the keratin cytoskeleton in colorectal cancer cells. We herein show that FAM83H regulates the organization of the keratin cytoskeleton and maintains the formation of desmosomes in ameloblastoma cells. FAM83H is expressed and localized on keratin filaments in human ameloblastoma cell lines and in mouse ameloblasts and epidermal germinative cells in vivo. FAM83H shows preferential localization to keratin filaments around the nucleus that often extend to cell-cell junctions. Alterations in the function of FAM83H by its overexpression, knockdown, or an AI-causing truncated mutant prevent the proper organization of the keratin cytoskeleton in ameloblastoma cells. Furthermore, the AI-causing mutant prevents desmosomal proteins from being localized to cell-cell junctions. The effects of the AI-causing mutant depend on its binding to and possible inhibition of casein kinase I (CK-1). The suppression of CK-1 by its inhibitor, D4476, disorganizes the keratin cytoskeleton. Our results suggest that AI caused by the FAM83H mutation is mediated by the disorganization of the keratin cytoskeleton and subsequent disruption of desmosomes in ameloblasts. PMID:27222304

  3. FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes

    Science.gov (United States)

    Kuga, Takahisa; Sasaki, Mitsuho; Mikami, Toshinari; Miake, Yasuo; Adachi, Jun; Shimizu, Maiko; Saito, Youhei; Koura, Minako; Takeda, Yasunori; Matsuda, Junichiro; Tomonaga, Takeshi; Nakayama, Yuji

    2016-01-01

    FAM83H is essential for the formation of dental enamel because a mutation in the FAM83H gene causes amelogenesis imperfecta (AI). We previously reported that the overexpression of FAM83H often occurs and disorganizes the keratin cytoskeleton in colorectal cancer cells. We herein show that FAM83H regulates the organization of the keratin cytoskeleton and maintains the formation of desmosomes in ameloblastoma cells. FAM83H is expressed and localized on keratin filaments in human ameloblastoma cell lines and in mouse ameloblasts and epidermal germinative cells in vivo. FAM83H shows preferential localization to keratin filaments around the nucleus that often extend to cell-cell junctions. Alterations in the function of FAM83H by its overexpression, knockdown, or an AI-causing truncated mutant prevent the proper organization of the keratin cytoskeleton in ameloblastoma cells. Furthermore, the AI-causing mutant prevents desmosomal proteins from being localized to cell-cell junctions. The effects of the AI-causing mutant depend on its binding to and possible inhibition of casein kinase I (CK-1). The suppression of CK-1 by its inhibitor, D4476, disorganizes the keratin cytoskeleton. Our results suggest that AI caused by the FAM83H mutation is mediated by the disorganization of the keratin cytoskeleton and subsequent disruption of desmosomes in ameloblasts. PMID:27222304

  4. Cytokeratin 14 and cytokeratin 18 expressions in reduced enamel epithelium and dentigerous cyst: Possible role in oncofetal transformation and histogenesis- of follicular type of adenomatoid odontogenic tumor

    Directory of Open Access Journals (Sweden)

    D K Shruthi

    2014-01-01

    Full Text Available Introduction: Odontogenic cysts and tumors arise from the structures and remnants associated with tooth development. Cysts and tumors derived from the odontogenic tissues constitute an unusually diverse group of lesions. This diversity reflects the complex development of the dental structures, since all these lesions originate through some alteration from the normal pattern of odontogenesis. Cytokeratin (CK 14 is the typical intermediary filament of odontogenic epithelium, CK 18 is the major components of the intermediate filaments of simple or single layered epithelial tissue; it is not expressed in stratified squamous epithelium. The present study was undertaken to understand the expression pattern of these cytokeratins in dentigerous cyst, dental follicular tissue, adenomatoid odontogenic tumor (AOT and unicystic ameloblastoma. Materials and Methods: The present study consists of 60 specimens consisting of 20 samples of Dentigerous cyst, 20 samples of Reduced enamel epithelium/dental follicles, 10 samples of Follicular type of AOT, 10 samples of unicystic ameloblastoma. The sections of these specimens were stained for CK 14 and CK 18. The number of cells positive for CK 14 and CK 18 was counted per 100 cells. The cells were counted in four randomly selected high-power fields and the mean was calculated. Scoring of cytokeratin 14 expressions was done using Remmele score. Results: The highest expression of cytokeratin 14 was noted in AOT, least was seen in dental follicle/Reduced enamel epithelium (REE. CK18 was negative in all the cases included in the present study. Conclusion: In the present study, the expression of CK14 was noted in AOT, Dentigerous cyst (DC, Unicystic Ameloblastoma (UCA and Dental follicle/REE. The expressions between these lesions were compared. These expression pattern may provide an insight to the histogenesis of AOT.

  5. Papilliferous Keratoameloblastoma: An Extremely Rare Case Report

    Directory of Open Access Journals (Sweden)

    Neeta Mohanty

    2013-01-01

    Full Text Available Odontogenic tumors develop in the jaw bones from the odontogenic tissue-oral epithelium in tooth germ, enamel organ, dental papilla, reduced enamel epithelium, remnants of Hertwig’s root sheath or dental lamina, and so forth. Hence, a bewildering variety of tumors are encountered in the maxilla and mandible. Ameloblastoma is the second most common odontogenic neoplasm after odontomes, and it has numerous clinical and histologic variants. We report a very rare histologic variant: the papilliferous keratoameloblastoma which is the fifth reported case in the English literature.

  6. Cyst or tumor in the buccomaxillary region: Review of literature and a case report.

    Science.gov (United States)

    Raheel, Syed Ahmed; Kujan, Omar Bashar; Dwedary, Hisham Mohammed Najeeb; Sikander, Mohammed Hilal; Mankar, Sunil; Amrin, M Nidha

    2015-08-01

    Odontogenic tumors (OTs) include entities of a hamartomatous nature, such as odontoma, benign neoplasms like an adenomatoid odontogenic tumor (AOT), some benign neoplasms are aggressive as in the case of ameloblastoma. The AOT is a rare odontogenic tumor constituting only 3% of all the OT and very often misdiagnosed as an odontogenic cyst. We report a case of an intra-osseous type of AOT occurred in a young 16-year-old female located in the anterior maxilla along with the clinical, radiological, histological features, and literature review related to the tumor affecting the patient. PMID:26538960

  7. Odontoameloblastoma: Report of two cases

    Directory of Open Access Journals (Sweden)

    Mosca Rodrigo

    2009-01-01

    Full Text Available Odontoameloblastoma (OA is a very rare mixed odontogenic neoplasm, characterized by the simultaneous occurrence of an ameloblastoma and a compound or complex odontoma in the same tumor mass. To date, less than 50 cases of OA and/or ameloblastic odontoma have been reported in the English dental literature. This neoplasm was called ameloblastic odontoma. The term OA was included in the 1971 WHO classification. In this study, we present two cases of OA, which we hope will contribute to the awareness and knowledge of surgeons regarding the existence of this odontogenic tumor so that patients having it may be treated and followed-up properly.

  8. [In Process Citation].

    Science.gov (United States)

    Bassetti, Renzo; Tomasetti, Patrick; Crameri, Manuel; Kuttenberger, Johannes

    2016-01-01

    Odontomas are classified within the group of odontogenic epithelial tumors with odontogenic ectomesenchyme with or without hard tissue formation. Together with ameloblastomas and keratocystic odontogenic tumors they are counted among the most common odontogenic tumors. Their growth is self-limiting and mostly, they are discovered accidentally as part of a x-ray examination. A common finding is that odontomas are associated with an unerupted permanent tooth. The aim of the present case report is to present the step-by-step procedure of a surgical odontoma removal in the lingual premolar/canine area of the lower jaw. PMID:27142310

  9. A Contemporary Approach to Classify Ghost Cells Comprising Oral Lesions

    Science.gov (United States)

    Yadav, Sumit Kumar; Narwal, Anjali; Devi, Anju

    2015-01-01

    Ghost cells are swollen eosinophilic epithelial cells that have lost their nuclei but retain the cellular and nuclear outline. Pathologic ghost cell formation could be the process of aberrant keratinization or the result of coagulative necrosis. Ghost cells have been described in several odontogenic lesions, which include calcifying epithelial odontogenic cysts or tumours like odontomas, ameloblastic fibro-odontomas, and ameloblastomas. This article present a view on the formation of ghost cells with proposal/introduction of a classification for ghost cell lesions of the oral cavity in an attempt to organize these lesions for the better understanding and academic purpose. PMID:26501039

  10. A Contemporary Approach to Classify Ghost Cells Comprising Oral Lesions.

    Science.gov (United States)

    Yadav, Achla Bharti; Yadav, Sumit Kumar; Narwal, Anjali; Devi, Anju

    2015-09-01

    Ghost cells are swollen eosinophilic epithelial cells that have lost their nuclei but retain the cellular and nuclear outline. Pathologic ghost cell formation could be the process of aberrant keratinization or the result of coagulative necrosis. Ghost cells have been described in several odontogenic lesions, which include calcifying epithelial odontogenic cysts or tumours like odontomas, ameloblastic fibro-odontomas, and ameloblastomas. This article present a view on the formation of ghost cells with proposal/introduction of a classification for ghost cell lesions of the oral cavity in an attempt to organize these lesions for the better understanding and academic purpose. PMID:26501039

  11. [The "globulomaxillary cyst" a specific entity or a myth?].

    Science.gov (United States)

    Häring, Philipp; Filippi, Andreas; Bornstein, Michael M; Altermatt, Hans Jörg; Buser, Daniel; Lambrecht, J Thomas

    2006-01-01

    The following review investigates the term and concept of the globulomaxillary cyst as a correct clinico-pathological diagnosis to describe a so-called fissural cyst said to be caused by epithelial entrapment between the nasal and maxillary process. After analyzing the available literature it has to be concluded that neither from an embryologic nor from a clinical or pathohistological standpoint the term globulomaxillary cyst represents a real entity by itself. Therefore, globulomaxillary cysts have to be diagnosed alternatively after a thorough clinical, radiological and histological examination as other odontogenic cysts like dentigerous cysts or odontogenic keratocysts, odontogenic tumors like ameloblastoma, central giant cell tumors, solitary bone cysts, etc. PMID:16708524

  12. Nitric Oxide: An Overview

    Directory of Open Access Journals (Sweden)

    Saleem Shaikh

    2015-07-01

    Full Text Available The small molecule nitric oxide (NO has a vast number of actions, many of which are poorly understood. Although NO is produced by three distinct isoforms of the enzyme nitric oxide synthase (NOS, most research is directed toward the form, iNOS which is seen following induction. Nitric oxide has been extensively researched in relation to cancer, where it has a multifaceted role. It has also been investigated in relation to oral lesions and tumors like ameloblastoma, salivary gland tumors, periapical lesions, S jogren’s syndrome, etc. This review looks into all these facets of NO and its potential role as a diagnostic and therapeutic modality.

  13. A study on the relationship between radiologic classification and glycosaminoglycan analysis of cystic fluids in oral region

    Energy Technology Data Exchange (ETDEWEB)

    Park, In Woo; You, Dong Soo [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1993-08-15

    This study was designed to evaluate the correlationship between radiologic classifications of cysts in oral region and glycosaminoglycan analysis of cystic fluids using cellulose acetate electrophoresis. The materials for this study consisted of 37 cases-8 periapical cysts, 10 dentigerous cysts, 10 primordial cysts, 2 residual cyst, 3 incisive canal cysts, 2 post-operative maxillary cysts, 1 mucocele on maxillary sinus, and 1 unicystic ameloblastoma-diagnosed as cystic lesions radiologically. The obtained results were as follows: 1. At the stepwise discriminant analysis, four variables-low mobility material, hiparin, hyaluronic acid, and dermatan sulfate- were used to define diagnostic model for the odontogenic cyst. The model produced a seventeenths of 100% and a specificity of 85%. 2. The intensities of heparin and chondroitin-4-sulfate were greater in dentigerous cyst than periapical cyst (p<0.05). 3. It showed no statistically significant difference in glycosaminoglycan of the cystic fluids between dentigerous cyst and primordial cyst (p<0.05). 4. On the fluids of the cysts originated from maxillary sinus, there were especially high intensities of heparin and dermatan sulfate, and low intensity of chondroitin-4-sulfate. 5. On the fluids of unicystic ameloblastoma, there were high intensity of dermatan sulfate and low intensity of chondroitin-4-sulfate.

  14. Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions

    Directory of Open Access Journals (Sweden)

    Saede Atarbashi Moghadam

    2013-01-01

    Full Text Available P63 may have a role in tumorigenesis and cytodifferentiation of odontogenic lesions. We investigated the immunohistochemical expression of P63 in a total of 30 cases of odontogenic cysts and tumors. The percentage of positive cells was calculated in the lining of odontogenic cysts and islands of ameloblastoma. P63 expression was evident in all types of odontogenic lesions. P63 was expressed throughout the lining epithelium of odontogenic keratocyst except surface parakeratinized layer. In addition, calcifying odontogenic cyst showed P63 expression in all layers. In almost all radicular and dentigerous cysts, the basal and parabasal layers were immunoreactive. Peripheral cells of ameloblastoma expressed P63; however, stellate reticulum had weaker immunostaining. No significant difference in P63 expression was observed between studied lesions (. Expression of P63 in odontogenic lesions suggests that this protein is important in differentiation and proliferation of odontogenic epithelial cells. However, it seems that it could not be a useful marker to differentiate between aggressive and nonaggressive lesions. P63 also represents a progenitor or basal cell marker, and it is not expressed in mature differentiated cells.

  15. Odontogenic tumors: analysis of 127 cases Tumores odontogênicos: análise de 127 casos

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    Jean Nunes SANTOS

    2001-12-01

    Full Text Available One hundred and twenty-seven cases of histologically confirmed odontogenic tumors were retrieved from a total of 5,289 oral and maxillary lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, during a period of 30 years (l970-l999. The most common histological diagnosis was odontoma (50.40%, followed by ameloblastoma (30.70%. The prevalence of odontogenic tumors was greater in females and the peak incidence occurred in the second and third decades of life. The main anatomical location was the mandible, and no malignant tumors were found.De uma série de 5.289 casos de lesões orais e dos maxilares diagnosticadas no Laboratório de Patologia Oral da Faculdade de Odontologia da Universidade Federal do Rio Grande do Norte no período de 30 anos (1970-1999, foram analisados 127 casos de tumores odontogênicos confirmados histologicamente. A lesão mais freqüente foi o odontoma (50,40% seguida pelo ameloblastoma (30,70%. A prevalência de tumores odontogênicos foi maior nas mulheres e o pico de incidência ocorreu na segunda e terceira décadas de vida. A localização anatômica mais comum foi a mandíbula e não foram encontrados casos de tumores malignos.

  16. Frequency of Odontogenic Tumors in Zahedan-Iran from 2000 to 2010

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    Hamideh Kadeh

    2012-01-01

    Full Text Available Introduction: Odontogenic tumors constitute an important aspect of oral and maxillofacial pathology. Frequency of odontogenic tumors varies in different societies but no study has been done in Zahedan so far. The purpose of this study was to achieve the sex, location and age distribution of odontogenic tumors and frequency of each one in a period of ten years.Materials & Methods: In this study, documents in archive of maxillofacial pathology department of Zahedan dental school, Khatamolanbia, Tamin ejtemaei Hospital and private laboratories were reviewed from 2000 to 2010. Data about age, sex, location of tumors and relation with impacted tooth were extracted and were submitted in the forms.Results: In this study, among the 1125 cases of the oromaxillofacial lesions, 50 cases of odontogenic tumors were found. Among the different tumors, keratocyst odontogenic tumor (KOT was the most common odontogenic tumor (48%, followed by ameloblastoma and odontoma with frequency of 24% and 12%, respectively. There were no cases of malignancy. The incidence of these lesions was 52% in women and 48% in men. The most common location of tumors was posterior of mandible and tumors were more frequent in the third decade of life. In 12 cases, the lesions were accompanied by impacted teeth.Conclusion: In this study the most frequent tumors were KOT, Ameloblastoma and odontoma respectively.

  17. CT findings of malignant tumors of maxillary sinus

    International Nuclear Information System (INIS)

    CT findings of histologically proven malignant tumors of maxillary sinus in 36 patients were retrospectively analyzed. A variety of malignant tumors were included; 27 cases of squamous cell carcinoma, 3 malignant lymphomas, 2 malignant melanomas, 2 rhabdomyosarcomas, and chondrosarcoma, adenoid cystic carcinoma, and malignant ameloblastoma. CT staging was T4 in 19 cases, T3 in 16 cases and T2 in 1 case. The most common involved area beyond maxillary antrum was nasal cavity (25 cases), followed by ethmoid sinus (20 cases), orbit (19 cases), infratemporal fossa (17 cases), check skin (13 cases), pterygopalatine fossa (10 cases), and nasopharynx (6 cases). Skeletal destruction was seen in medial wall of antrum (31 cases), posterior wall of antrum (25 cases), anterior wall of antrum (23 cases), roof of antrum (19 cases), lamina papyracea (6 cases), and lateral wall of orbit (5 cases) in that order of frequency. Lymph node metastases were found in 2 cases of malignant melanoma, 2 cases of malignant lymphoma, and chondrosarcoma, squamous cell carcinoma, and malignant ameloblastoma. Predilection site of lymph node involvement was submandibular (3 cases), internal jugular (2 cases), parotid (2 cases), and retropharyngeal node (1 case)

  18. A study on the relationship between radiologic classification and glycosaminoglycan analysis of cystic fluids in oral region

    International Nuclear Information System (INIS)

    This study was designed to evaluate the correlationship between radiologic classifications of cysts in oral region and glycosaminoglycan analysis of cystic fluids using cellulose acetate electrophoresis. The materials for this study consisted of 37 cases-8 periapical cysts, 10 dentigerous cysts, 10 primordial cysts, 2 residual cyst, 3 incisive canal cysts, 2 post-operative maxillary cysts, 1 mucocele on maxillary sinus, and 1 unicystic ameloblastoma-diagnosed as cystic lesions radiologically. The obtained results were as follows: 1. At the stepwise discriminant analysis, four variables-low mobility material, hiparin, hyaluronic acid, and dermatan sulfate- were used to define diagnostic model for the odontogenic cyst. The model produced a seventeenths of 100% and a specificity of 85%. 2. The intensities of heparin and chondroitin-4-sulfate were greater in dentigerous cyst than periapical cyst (p<0.05). 3. It showed no statistically significant difference in glycosaminoglycan of the cystic fluids between dentigerous cyst and primordial cyst (p<0.05). 4. On the fluids of the cysts originated from maxillary sinus, there were especially high intensities of heparin and dermatan sulfate, and low intensity of chondroitin-4-sulfate. 5. On the fluids of unicystic ameloblastoma, there were high intensity of dermatan sulfate and low intensity of chondroitin-4-sulfate.

  19. Evaluation of Amelotin Expression in Benign Odontogenic Tumors

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    Daiana Paula Stolf

    2013-10-01

    Full Text Available Objective: Amelotin (AMTN is highly and selectively expressed by odontogenic epithelium-derived ameloblasts throughout the maturation stage of enamel formation. The protein is secreted and concentrated at the basal lamina interface between ameloblasts and the mineralized enamel matrix. Odontogenic tumors (OT are characterized by morphological resemblance to the developing tooth germ. OT vary from slowly expanding, encapsulated tumors to locally aggressive and destructive lesions. The purpose of this study was to determine the expression profile of AMTN in benign odontogenic tumors and to correlate it with specific features of the lesions. Methods: Immunohistochemical staining for AMTN was performed on human ameloblastoma, ameloblastic fibroma (AF, ameloblastic fibro-odontoma (AFO, odontoma, adenomatoid odontogenic tumor (AOT and calcifying cystic odontogenic tumor (CCOT. Results: Generally, ameloblastoma and AF did not stain for AMTN. A strong signal was detected in ameloblast-like layers of AFO and odontoma. Epithelial cells in AOT did not stain for AMTN, while calcifying areas of extracellular eosinophilic matrix were intensely stained. Interestingly, ghost cells present in odontomas and CCOT revealed variable staining, again in association with calcification foci. Conclusions: Amelotin expression was consistently detected in tumors presenting differentiated ameloblasts and obvious matrix deposition. Additionally, the presence of the protein in the eosinophilic matrix and small mineralized foci of AOT and calcification areas of ghost cells may suggest a role for AMTN in the control of mineralization events. [J Interdiscipl Histopathol 2013; 1(5.000: 236-245

  20. Incidental bony pathology when reporting trauma orthopantomograms

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    Macanovic, M., E-mail: mladenmaca@gmail.co [Derriford Hospital NHS Trust, Plymouth (United Kingdom); Gangidi, S.; Porter, G.; Brown, S.; Courtney, D. [Derriford Hospital NHS Trust, Plymouth (United Kingdom); Porter, J. [Community Dental Service, Plymouth Primary Care Trust, Plymouth, Devon (United Kingdom)

    2010-10-15

    Radiologists frequently report orthopantomograms (OPTs) and other views of the mandible, most often in patients who have suffered facial trauma. These examinations may reveal incidental pathology. It is important that radiologists are aware of the radiological appearances and the clinical significance of these lesions. In this review we will present examples of the more common odontogenic lesions including: radicular cyst, odontogenic keratocyst, dentigerous cyst, ameloblastoma, and also examples of non-odontogenic pathology: bisphosphonate-related osteonecrosis of the jaw (BRONJ) and chronic osteomyelitis. Although some of the lesions will require computed tomography (CT) or magnetic resonance imaging (MRI) for further lesion characterization and evaluation of the surrounding tissues, we are going to focus on the plain film appearances. We will also briefly discuss the pathogenesis, epidemiology, and treatment of these lesions.

  1. Melanotic neuroectodermal tumor of infancy

    International Nuclear Information System (INIS)

    Melanotic neuroectodermal tumor of infancy is an uncommon neoplasm occurring primarily in the child one year or less in age. Difficulty in deciding the cellular origin of this tumor has led to numerous names, including congenital melanocarcinoma, melanotic epithelial odontoma, melanotic ameloblastoma, and retinal anlage tumor, to list a few. Electron microscopy and histochemical studies, however, have now established the neural crest the most likely origin. The most frequent site of occurrence is the maxilla followed by the skull, the brain and the mandible. The genital organs are the most frequent extracranial site. Within the skull, there is a predilection for the anterior fontanel. The following is a case report of a young child with melanotic neuroectodermal tumor of infancy arising at the anterior fontanel. Included is a discussion of magnetic resonance (MR) findings, which to our knowledge, have not been previously reported in this tumor. (orig.)

  2. Odontoameloblastoma: A case report

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    Amita Negi

    2015-01-01

    Full Text Available Odontoameloblastoma (OA is an extremely rare odontogenic tumor that contains an ameloblastomatous component together with odontoma-like elements. Till date, very few cases have fulfilled the criteria of the current World Health Organization classification of odontogenic tumors. It is characterized by slow, progressively growing lesion with growth pattern similar to solid multi-cystic ameloblastoma. The majority of the tumors are associated with unerupted teeth and commonly seen in males. It is usually asymptomatic and may occur in either maxilla or mandible, but shows a slight predilection for mandible. As this tumor is extremely rare, there exists controversy regarding its treatment. Here, we present a case of OA in 17-year-old female patient resembling a fibro-osseous lesion and a brief review of the related literature.

  3. Adenomatoid odontogenic tumor in mandibular region

    International Nuclear Information System (INIS)

    The adenomatoid odontogenic tumor is an uncommon neoplasm derivative of the odontogenic epithelium containing canalicular structures with inductor modifications of variable intensity in the conjunctival tissue. It is a slow growth lesion and no much invasive but that may to be similar to other odontogenic lesions more aggressive including the dentigerous cyst and the ameloblastoma among others. Its classical location (upper canine area) guides us to diagnosis and its duct histological pattern is very typical of this tumor. Other tumors included in this group are the ameloblastic fibroma, the ameloblastic odontoma, the calcified odontogenic cyst and composed and complex odontomas. This group of lesions may or not to have formations of hard tissue inside. Thus, authors present the case of a patient presenting with this type of tumor making a histopathology study, a literature review on this benign odontogenic tumor and its clinical radiographic features, treatment, as well as the differential diagnoses to be into account. (author)

  4. Bilateral Calcifying Cystic Odontogenic Tumour of Mandible: A Rare Case Report and Review of Literature.

    Science.gov (United States)

    Khandelwal, Pragun; Aditya, Amita; Mhapuskar, Amit

    2015-11-01

    Calcifying cystic odontogenic tumour (CCOT) is a relatively rare lesion of oral and maxillofacial region and forms only 2% of all odontogenic tumours. It was previously known as Calcifying odontogenic cyst and only recently has been classified as a tumour by WHO. The controversy regarding its origin can be owed to its diverse clinical and histopathological presentation and variation in reported malignant potential. It was first reported by Gorlin in 1962 and since then conundrum regarding its true nature has persisted. It is seen in association with other lesions like odontoma, ameloblastoma and ameloblastic fibroma. Both intra-osseous and extra-osseous forms of CCOT have been reported. It commnoly occurs in anterior region with equal preponderance in maxilla and mandible. Here we present a rare case of bilateral CCOT in the posterior mandible of a 16-year-old male patient which was discovered incidentally during a radiographic examination. PMID:26673837

  5. Melanotic neuroectodermal tumor of infancy. MR findings and a review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, G.O. Jr.; Davis, P.C.; Patrick, L.E.; Winn, K.J.; Ball, T.I.; Wyly, J.B. (Emory Univ., Atlanta, GA (USA). Dept. of Radiology)

    1989-11-01

    Melanotic neuroectodermal tumor of infancy is an uncommon neoplasm occurring primarily in the child one year or less in age. Difficulty in deciding the cellular origin of this tumor has led to numerous names, including congenital melanocarcinoma, melanotic epithelial odontoma, melanotic ameloblastoma, and retinal anlage tumor, to list a few. Electron microscopy and histochemical studies, however, have now established the neural crest the most likely origin. The most frequent site of occurrence is the maxilla followed by the skull, the brain and the mandible. The genital organs are the most frequent extracranial site. Within the skull, there is a predilection for the anterior fontanel. The following is a case report of a young child with melanotic neuroectodermal tumor of infancy arising at the anterior fontanel. Included is a discussion of magnetic resonance (MR) findings, which to our knowledge, have not been previously reported in this tumor. (orig.).

  6. Odontoameloblastoma: A case report.

    Science.gov (United States)

    Negi, Amita; Puri, Abhiney; Nangia, Rajat; Sachdeva, Alisha

    2015-01-01

    Odontoameloblastoma (OA) is an extremely rare odontogenic tumor that contains an ameloblastomatous component together with odontoma-like elements. Till date, very few cases have fulfilled the criteria of the current World Health Organization classification of odontogenic tumors. It is characterized by slow, progressively growing lesion with growth pattern similar to solid multi-cystic ameloblastoma. The majority of the tumors are associated with unerupted teeth and commonly seen in males. It is usually asymptomatic and may occur in either maxilla or mandible, but shows a slight predilection for mandible. As this tumor is extremely rare, there exists controversy regarding its treatment. Here, we present a case of OA in 17-year-old female patient resembling a fibro-osseous lesion and a brief review of the related literature. PMID:26604505

  7. Prominent response with helical tomotherapy in recurrent ameloblastic carcinoma of maxillary sinus: a case report

    International Nuclear Information System (INIS)

    Ameloblastoma is a benign but locally aggressive tumor of odontogenic epithelial tissue. Reports of radiotherapy treatment modalities are limited in the literature. A thirty-five year old male presented with complaints of headache radiating to his face for about six months and impaired vision. The patient’s Positron Emission Tomography (PET) showed a mass in the left maxillary sinus extending to the nasal cavity and invading the adjacent tissues. An R2 (macroscopic residual tumor) surgical resection performed to debulk the tumor. Due to the recurrence and residual mass, the patient was treated with helical tomotherapy. At 2 months post-radiotherapy, patient’s vision returned to normal. PET scan showed a significant reduction in lesion size 12 months post-radiation. In cases of ameloblastic carcinoma with, post-surgical recurrence or patients not suitable for surgical treatment, helical tomotherapy can be an effective treatment option

  8. Two cases report of Calcifying Odontogenic Cyst

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    Lee, Byung Do; Lee, Wan; Paeng, Jun Young; Lee, Jun; Choi, Moon Ki [School of Dentistry, Wonkwang University, Wonkwang Dental Research Institute, Jeonju (Korea, Republic of); Son, Hyun Jin [Department of Pathology, School of Medicine, Eulji University, Daejeon (Korea, Republic of)

    2009-09-15

    The calcifying odontogenic cyst (COC) is a rare disorder of the jaws and shows various radiographic features. The purpose of this study is to describe the different radiographic appearances of 2 cases of COC. Case 1 was located in the posterior maxilla extending into maxillary sinus, showing unilocular radiolucency with a well-defined margin. Cortical bone expansion and thinning were prominent. Root resorption of adjacent teeth was apparent. Case 2 showed unilocular radiolucency with a calcified material. Calcification was supposed to be dystrophic dental hard structures, detected at the periphery of the lesion. Ghost cell and proliferation of ameloblastoma-like tissues were common features for these two lesions on histopathological findings. This reports presented common and atypical radiographic features of the COC.

  9. Two cases report of Calcifying Odontogenic Cyst

    International Nuclear Information System (INIS)

    The calcifying odontogenic cyst (COC) is a rare disorder of the jaws and shows various radiographic features. The purpose of this study is to describe the different radiographic appearances of 2 cases of COC. Case 1 was located in the posterior maxilla extending into maxillary sinus, showing unilocular radiolucency with a well-defined margin. Cortical bone expansion and thinning were prominent. Root resorption of adjacent teeth was apparent. Case 2 showed unilocular radiolucency with a calcified material. Calcification was supposed to be dystrophic dental hard structures, detected at the periphery of the lesion. Ghost cell and proliferation of ameloblastoma-like tissues were common features for these two lesions on histopathological findings. This reports presented common and atypical radiographic features of the COC.

  10. Incidental bony pathology when reporting trauma orthopantomograms

    International Nuclear Information System (INIS)

    Radiologists frequently report orthopantomograms (OPTs) and other views of the mandible, most often in patients who have suffered facial trauma. These examinations may reveal incidental pathology. It is important that radiologists are aware of the radiological appearances and the clinical significance of these lesions. In this review we will present examples of the more common odontogenic lesions including: radicular cyst, odontogenic keratocyst, dentigerous cyst, ameloblastoma, and also examples of non-odontogenic pathology: bisphosphonate-related osteonecrosis of the jaw (BRONJ) and chronic osteomyelitis. Although some of the lesions will require computed tomography (CT) or magnetic resonance imaging (MRI) for further lesion characterization and evaluation of the surrounding tissues, we are going to focus on the plain film appearances. We will also briefly discuss the pathogenesis, epidemiology, and treatment of these lesions.

  11. Odontogenic Keratocyst Looks Can Be Deceptive, Causing Endodontic Misdiagnosis

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    K. M. Veena

    2011-01-01

    Full Text Available Odontogenic keratocyst (OKC is the cyst arising from the cell rests of dental lamina. It can occur anywhere in the jaw, but commonly seen in the posterior part of the mandible. Radiographically, most OKCs are unilocular when presented at the periapex and can be mistaken for radicular or lateral periodontal cyst. When the cyst is multilocular and located at the molar ramus area, it may be confused to ameloblastoma. Lots of cases have been reported in the literature where OKC is associated with the nonvital tooth. So trauma could be one of the reasons in inducing this cyst. In our case, it was in the anterior region at the periapex of nonvital tooth having traumatic occlusion. Hence, the diagnosis of radicular cyst was made and endodontic treatment was done.

  12. Clinical and Radiographic Study of Benign Odontogenic Tumors in the Jaws

    International Nuclear Information System (INIS)

    The author observed and analyzed the age, sex, chief complaint and radiographic finding of sixty-one cases of benign odontogenic tumors seen in Yonsei Medical Center, for the period of Jan. 1979 to Aug. 1989. The results were as follows: 1. Benign odontogenic tumors of 61 cases included 52 cases (85.3%) of ameloblastoma and odontoma, and 9 cases of other lesions. Radiographically, the border of the lesions were well-defined. 2. Ameloblastoma constituting twenty-seven cases (44.3%) occurred the average age of 31.1 years and had a 3:1 male predominance. The most common complaint was swelling (20 cases, 74.0%) and followed by pain (13 cases, 48.2%). Radiographically, the most common site was mandibular body area (74.0%) and the lesions were mainly multiocular radiolucency; in 17 cases (63.0%) and unilocular radiolucent lesion were seen in 10 cases (37.0%). 16 cases (59.3%) showed the resorption of roots of adjacent teeth. 3. Odontoma constituting twenty-five cases (41.0%) discovered at the average age of 16.9 years and had a 3:2 male predominance. The most common complaint was delayed eruption of tooth (8 cases, 31.0%) and 7 cases (27.0%) detected on a routine radiograph of the area. Radiographically, 17 cases (68.0%) were of compound type and 8 were of complex variety and compound odontomas were common in the anterior maxilla, whereas complex odontomas occurred more frequently in the posterior mandible. 19 cases (76.0%) showed the impaction of adjacent teeth.

  13. Clinical and Radiographic Study of Benign Odontogenic Tumors in the Jaws

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    Kim, Gyung Yae; Park, Chang Seo [Dept. of Oral Radiology, College of Dentistry, Yonsei University, Seoul (Korea, Republic of)

    1989-11-15

    The author observed and analyzed the age, sex, chief complaint and radiographic finding of sixty-one cases of benign odontogenic tumors seen in Yonsei Medical Center, for the period of Jan. 1979 to Aug. 1989. The results were as follows: 1. Benign odontogenic tumors of 61 cases included 52 cases (85.3%) of ameloblastoma and odontoma, and 9 cases of other lesions. Radiographically, the border of the lesions were well-defined. 2. Ameloblastoma constituting twenty-seven cases (44.3%) occurred the average age of 31.1 years and had a 3:1 male predominance. The most common complaint was swelling (20 cases, 74.0%) and followed by pain (13 cases, 48.2%). Radiographically, the most common site was mandibular body area (74.0%) and the lesions were mainly multiocular radiolucency; in 17 cases (63.0%) and unilocular radiolucent lesion were seen in 10 cases (37.0%). 16 cases (59.3%) showed the resorption of roots of adjacent teeth. 3. Odontoma constituting twenty-five cases (41.0%) discovered at the average age of 16.9 years and had a 3:2 male predominance. The most common complaint was delayed eruption of tooth (8 cases, 31.0%) and 7 cases (27.0%) detected on a routine radiograph of the area. Radiographically, 17 cases (68.0%) were of compound type and 8 were of complex variety and compound odontomas were common in the anterior maxilla, whereas complex odontomas occurred more frequently in the posterior mandible. 19 cases (76.0%) showed the impaction of adjacent teeth.

  14. Fibroma ameloblástico versus quiste folicular hiperplásico Ameloblastic fibroma versus hyperplastic follicular cyst

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    J. Azúa-Romeo

    2004-06-01

    Full Text Available Resumen: El fibroma ameloblástico (FA es un tumor odontogénico mixto, compuesto por tejido mesenquimal y epitelio odontogénico, representando el 2% de los tumores odontogénicos, mientras que el quiste dentígero o folicular (QF, el segundo quiste odontogénico en frecuencia, está compuesto exclusivamente por tejido conjuntivo laxo (mesénquima, si bien, el saco fibroso puede contener restos de epitelio odontogénico incluidos, dando lugar a una imagen histológica muy similar. La importancia de esta diferenciación radica en el tratamiento, que es ligeramente más agresivo en el FA y en el comportamiento biológico, ya que el FA puede derivar en un sarcoma ameloblástico, y el QF puede evolucionar hacia ameloblastoma y más raramente carcinoma mucoepidermoide.Abstract: Ameloblastic fibroma (AF is a mixed odontogenic tumor composed of mesenchymal tissue and odontogenic epithelium, accounting for 2% of all odontogenic tumors, while dentigerous or follicular cyst (FQ, second odontogenic cyst in frequency, is formed exclusivelly by soft conective tissue (mesenchyme. Nevertheless, hiperplastic fibrous sac may contain rests of odontogenic epithelium, showing a similar histologic pattern. The importance of an adequate differentiation lies in the treatment, which is slightly aggresive for AF, and regarding the biological behaviour of both lesions, since AF might become in an ameloblastic sarcoma, while over an FQ could develope an ameloblastoma or even a mucoepidermoid carcinoma.

  15. The preliminary application of bone imaging in oral and maxillofacial surgical patients

    International Nuclear Information System (INIS)

    Objective: To evaluate the clinical value of bone imaging for the diagnosis and differential diagnosis of oral and maxillofacial surgical patients and to clarify whether the mandible is invaded by the adjacent lesion. Methods: Routine planar three-phase bone scintigraphy and semiquantitative mandibular tomography were performed on 5 controls and 15 patients. Of these 15 patients, 3 cases were with ameloblastoma of mandible, 5 cases with intraoral squamous carcinoma, 2 cases with embryonal rhabdomyosarcoma, 1 case with hemangioma of tongue, 1 case with sarcoma of mandible, 1 case with mandibular cyst, 1 case with chronic parotitis and 1 postextraction patient. Results: All of 3 ameloblastomas of mandible showed high uptake of 99Tcm-MDP. The mandibles invaded by intraoral squamous carcinoma and the embryonal rhabdomyosarcoma showed that the ratio of lesion-to-cervical vertebrae (L/C) was more than 1; the mandibles not invaded by intraoral squamous carcinoma and embryonal rhabdomyosarcoma showed that the L/C was less than 1; the tongue hemangioma showed a high uptake of 99Tcm-MDP in blood flow phase and blood pool phase, but no high uptake of 99Tcm-MDP in bone imaging. For the postextraction case, the alveolar bone showed a high uptake of 99Tcm-MDP in mandibular tomography, but L/C was less than 1; mandibular carcinomas showed a high uptake of 99Tcm-MDP in mandibular tomography, L/C was 1.01. Conclusions: Routine planar three-phase bone scintigraphy and semiquantitative mandibular tomography is a useful method for the diagnosis and differential diagnosis of diseases in oral and maxillofacial surgery, and it is also helpful for finding out the limits of foci and invasion of mandibles by the lesions in adjacent tissue in clinical practising

  16. Evaluation of mandibular bone involvement by oral malignant tumors using scintigraphy of Tc-99m MDP and Ga-67 citrate

    International Nuclear Information System (INIS)

    Ten patients with intensely invaded malignant tumors at the mandibles were studied with bone scintigraphy (Tc-99m MDP) and Ga-67 citrate scintigraphy. All patients were classified by type of accumulation of both radionuclide pharmaceuticals. In almost all patients with invaded malignant tumors, bone scintigraphy revealed decreasing uptake in the center of the lesion and increasing uptake in the peripheral region. Ga-67 citrate scintigram showed increasing concentrated accumulation which was smaller than the area of Tc-99m MDP uptake in almost all cases. These types of accumulation were compared with those of other oral and maxillo-facial diseases. The patterns of accumulation of both radionuclide pharmaceuticals in ameloblastoma (3 cases), radicular cyst (3 cases), bone fracture (2 cases), diffuse sclerosing osteomyelitis (2 cases), and one sagittal ramus osteotomy case were different from that of bone involvement of malignant tumor cases. From the types of accumulation, we may be able to differentiate the oral and maxillo-facial diseases to some extent. In addition, the intensity of accumulation of Tc-99m MDP was measured by using bone to soft tissue ratio (4 hrB/St ratio). The mean 4 hrB/St ratio was higher in moth-eaten absorbed type than in permeated type of resorption in roentgenogram. However, we could not obtain a definitive conclusion because of too few cases. The mean 4 hrB/St ratio in the bone involvement by malignant tumor was higher than that in radicular cyst, and lower than that of diffuse sclerosing osteomyelitis. Unfortunately, we could not differentiate each disease of the involved malignant tumor, ameloblastoma, or bone fracture by only the 4 hrB/St ratio. The Tc-99m MDP accumulated beyond the region where the radiolucencies exist in roentgenograms. We consider that both scintigraphies have a great role in planning surgical treatment, especially in selecting osteotomy. (author)

  17. A clinical study on osseous regeneration in the jaw defects using a composite of coral and bone marrow%珊瑚/骨髓复合人工骨修复颌骨缺损的临床应用研究

    Institute of Scientific and Technical Information of China (English)

    张森林; 孟昭业; 杨震; 董震; 寿柏泉

    2001-01-01

    Objectives:To evaluate the efficiency of packing jaw defects with a composite of coral and bone marrow. Methods:Twelve patients (9 with jaw cyst and 3 with ameloblastoma) underwent enucleation of jaw lesion and packing with a composite of coral and bone marrow.Repair of the bone defects was evaluated at 1 week,1,6 and 12 months postoperatively by clinical examination and X-ray films. Results:Wound healing after the operations on 10 patients was uneventful,and definite ossification around the implanted material could be detected at 1 month postoperatively.A lot of bone formation and partial resorption of coral were observed at 6 months postoperatively.Complete resorption of coral and complete bone repair were obtained at 12 months postoperatively.Wound breakdown was observed on two other patients,and the composite had to be removed completely. Conclusions:A composite of coral and bone marrow may enhances bone healing in jaw defects after cyst or ameloblastoma removal.%目的:评价珊瑚/骨髓复合人工骨修复颌骨缺损的疗效。方法:将珊瑚/骨髓复合人工骨用于充填9例颌骨囊肿和3例造釉细胞瘤术后遗留的骨腔,术后1周、1、6和12个月通过临床和X线检查以评价其骨修复效果。结果;10例伤口Ⅰ期愈合,术后1个月缺损区有新骨形成;6个月缺损区可见大量成熟的骨组织,部分珊瑚被降解吸收;12个月珊瑚完全被宿主骨取代,缺损区得到完全修复。另有2例因伤口裂开需去除珊瑚骨。结论:珊瑚/骨髓复合人工骨可促进颌骨缺损的修复,是较理想的骨移植替代材料。减少缝合时伤口的张力是植骨成功的关键。

  18. Tumors and tumor - like lesions of the oro - facial region at Mayo hospital, Lahore - a five year study

    International Nuclear Information System (INIS)

    The oro-facial region including the oral cavity, the maxilla and mandible and related tissues can be the site of a multitude of neoplastic conditions. These tumours have a predilection for the entire facial region; however, odontogenic tumours tend to affect the mandible more than the maxilla. We report results from a retrospective study spanning five years on the frequency, clinical presentation, sites and character of orofacial tumors seen in the main referral hospital of Pakistan. Patients and Methods: Records of consecutive patients of all age and sex seen by the author's team at the Department of Oral and Maxillofacial Surgery, Mayo Hospital with tumours affecting the oro-facial region from January 2005 to December 2009 were retrieved, coded and entered into a database. The data were then analyzed by age, sex, presenting signs and symptoms, site of lesion, and their histology. Results: A total of 237 patients with oro-facial swellings were retrieved from the registry. The complete data set was obtained for 189 patients, comprising 108 (57.9%) males and 81 (42%) females. The most common clinical presenting features were mandibular facial swelling (63%), intra-oral swelling (55%), and ulceration (29%). The tumors were found in the mandible 67 (35%), buccal mucosa 33 (17%), floor of the mouth 22 (11%) and tongue 29 (15%). The remainder making up almost 20% was found in the palate, submandibular region, pre auricular region and lips. Ninety three (49.2%) of the patients presented with lesions that were classified as malignant of which 64 (69%) were diagnosed as squamous cell carcinoma (SCC). seventy (37.0%) had benign odontogenic tumors and twenty six (13.7%) had non-odontogenic tumor - like lesions. Sixty - four (69%) of malignant tumors were squamous cell carcinoma; sixty four (86.4%) of the benign odontogenic tumors were classified as ameloblastoma. The mean age at presentation of all lesions was 40.4 years with over 50% of benign lesions in patients aged

  19. Parameters in panoramic radiography for differentiation of radiolucent lesions

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    Ricardo Raitz

    2009-10-01

    Full Text Available OBJECTIVE: The aims of this study were to establish parameters in panoramic radiography for interpretation of unilocular radiolucent lesions, and to compare the accuracy of diagnoses given by examiners before and after using these parameters. MATERIAL AND METHODS: In Part I, 12 specialists analyzed 24 images and the diagnostic criteria used by each examiner to make correct diagnoses were used to build a list of basic radiographic parameters for each pathology (ameloblastoma, keratocystic odontogenic tumor, dentigerous cyst, and idiopathic bone cavity. In Part II, this list was used by 6 undergraduate students (Un, 8 recently graduated dentists (D, 3 oral pathologists, 3 stomatologists, 3 oral radiologists, and 3 oral surgeons to diagnose the corresponding pathologies in the other set of 24 panoramic radiographs (T2. The same analysis occurred without using this list (T1. The method of generalized estimating equations (GEE was used in order to estimate the probability of making a correct diagnosis depending on the specialty of the examiner, type of lesion, and moment of the evaluation, T1 or T2 (before or after they had access to the list of parameters, respectively. RESULTS: Higher values were obtained for the probability (GEE of making a correct diagnosis on T2; the group Un presented the highest improvement (14.6 %; no differences between the probabilities were observed either between Un and D, or among the different groups of specialists. CONCLUSIONS: The use of panoramic radiographic parameters did allow improving the diagnostic accuracy for all groups of examiners.

  20. Pleomorphic Adenoma of the Palate in a 10-year-old Child: A Case Report

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    SH Tabatabaei

    2016-03-01

    Full Text Available Salivary gland tumors  are  uncommon  within  children and  when  they do arise,  they  mainly  affect  the  major  salivary glands. Minor salivary gland  tumors  are  rare  in  children, which are  responsible for less than 10% of all the cases. Pleomorphic adenoma is the most common tumor of  the salivary glands in the all ages. A 10-year-old boy referred to the dentistry clinic with a swelling in the palate of adjacent unerupted right maxillary second molar. In sampling by curettage, clinical pathologist reported ameloblastoma. The patient was referred to the dental school of Shahid Sadoughi University of Medical Sciences for consultation. Second  microscopic analysis showed a benign pleomorphic adenoma that was confirmed by special staining periodic acid-Schiff (PAS, immunohistochemistry cytokeratin(CK, and S100 staining. Pleomorphic adenoma of minor salivary gland of children should be considered as a differential diagnosis of intraoral swelling in the palate.

  1. Radiological and histopathological study of benign tumors of the mandible

    International Nuclear Information System (INIS)

    Benign tumors of the mandible are uncommon lesions. That were classified into odontogenic tumors and nonodontogenic tumors. Author reviewed the radiological evaluation and pathological microscopic finding from 33 benign tumors of the mandible that were confirmed by the biopsy during last 10 years in Dental Clinics, Ewha Womans University Hospital and Seoul National University Dental Hospital. Following results were obtained; 1. Benign tumors of the mandible were classified into odontogenic (66.7%) and non-odontogenic tumors (33.3%). 2. The range of the age distribution was between 6 years and 67 years old. The commonest age group was the second decade (39.4%). 3. There was no difference to sex distribution. 4. The most frequent location was the body of the mandible (42.4%). 5. Radiographic findings were relatively characteristic in odontogenic tumors rather than non-odontogenic tumors. 1) Radiolucent cystic lesions-ameloblastoma, odontogenic myxoma, odontogenic fibtoma, aneurysmal bone cyst and neurofibroma. 2) Radiopaque mass lesions-odontoma, cementoma and osteoma. 3) Mixed patterns-ossifying fibroma, cementifying fibroma, calcifying odontogenic epithelial tumor and hemangioma. It was concluded that the radiographic examination was of value to diagnose the benign tumors of the mandible in symptomless patients

  2. Digital image processing of mandibular trabeculae on radiographs

    International Nuclear Information System (INIS)

    The present study was aimed to reveal the texture patterns of the radiographs of the mandibular trabeculae by digital image processing. The 32 cases of normal subjects and the 13 cases of patients with mandibular diseases of ameloblastoma, primordial cysts, squamous cell carcinoma and odontoma were analyzed by their intra-oral radiographs in the right premolar regions. The radiograms were digitized by the use of a drum scanner densitometry method. The input radiographic images were processed by a histogram equalization method. The result are as follows : First, the histogram equalization method enhances the image contrast of the textures. Second, the output images of the textures for normal mandible-trabeculae radiograms are of network pattern in nature. Third, the output images for the patients are characterized by the non-network pattern and replaced by the patterns of the fabric texture, intertwined plants (karakusa-pattern), scattered small masses and amorphous texture. Thus, these results indicates that the present digital image system is expected to be useful for revealing the texture patterns of the radiographs and in the future for the texture analysis of the clinical radiographs to obtain quantitative diagnostic findings. (author)

  3. Odontogenic Tumors: A 13-year Retrospective Study of 395 Cases in a South Indian Teaching Institute of Kerala

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    Deepak Pandiar

    2015-07-01

    Full Text Available Objective: T he aim o f the present study was to determine the epidemiology and clinicopathological presentation of odonto­ genic tumors (OTs seen in a Government Teaching Institute from Kozhikode district of Kerala (South India, over a period of 13 years and to compare the data obtained with previous reports published in literature from different world population. Study design: Records of the Oral Pathology and Microbio logy, Government Dental College, Kozhikode (Kerala, South India, were analyzed during a period of 13 years and reclassified accor- ding to World Health Organization (WHO 2005 Classification. Results: A total of 6.08% of odontogenic tumors were reported out of which (96.7% were benign and (3.3% were malignant. Keratocystic odontogenic tumor (35.9% was the most frequent type, followed by ameloblastoma (25.9%, calcifying cystic odonto genic tumor (10.6% , and odontoma (8.9%. The mean age was 32.69 ± 17.2 7, and males were more commonly affected. Conclusion: A marked geographic and demographic variation was observed in the relative frequency of various odontogenic tumors in the South Indian population which stresses upon the influence of genetic and/or environmental (epigenetic factors on tumor pathogenesis.

  4. Tindakan ‘Surgical Exposure’ pada Impaksi Gigi Insisif Satu Atas (Laporan Kasus

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    Sarworini B Budiardjo

    2015-11-01

    Full Text Available Gigi impaksi adalah gigi yang tertahan di dalam tulang rahang, secara klinis dapat dijumpai sebagai gigi yang lambat erupsi, gigi yang tertutup kembali oleh jaringan selama proses erupsi, atau proses erupsi yang berhenti. Penyebab terjadinya impaksi sebagai akibat gangguan patologik seperti ameloblastoma, ameloblastic fibrousodontoma, atau kista dentigerous dan gangguan non patologik berupa penebalan jaringan ikat akibat pencabutan gigi terlalu awal. Impaksi gigi insisif satu tetap atas sering dihubungkan dengan terjadinya odontoma, gigi supernumerary, pasien cleiocranial dysostosis, dan traumatic injuries. Perawatan gigi impaksi sesuai dengan penyebab; bila disebabkan faktor patologik, maka pengambilan seluruh gigi menjadi pilihan perawatan. Pada gigi impaksi akibat faktor non patologik, maka dilakukan tindakan bedah dengan tujuan membuka jalan erupsi (surgical exposure. Setelah surgical exposure dapat dilakukan pemasangan mahkota dari seluloid atau alumunium shell yang disemenkan pada mahkota gigi. Pada laporan kasus ini anak wanita usia 10 tahun dengan gigi insisif satu tetap atas kiri yang mengalami impaksi di bagian palatal dan untuk membantu erupsi dilakukan tindakan bedah disertai pemasangan mahkota seluloid. Tindakan tersebut dilakukan setelah mengalami kegagalan pada pembedahan pertama dengan terjadinya pertautan jaringan lunak, sehingga gigi tetap mengalami kesulitan erupsi. Hasil perawatan kedua menunjukkan keberhasilan, setelah 10 bulan perawatan gigi insisif satu tetap atas kiri erupsi lebih dari duapertiga mahkota.

  5. Digital image processing of mandibular trabeculae on radiographs

    Energy Technology Data Exchange (ETDEWEB)

    Ogino, Toshi

    1987-06-01

    The present study was aimed to reveal the texture patterns of the radiographs of the mandibular trabeculae by digital image processing. The 32 cases of normal subjects and the 13 cases of patients with mandibular diseases of ameloblastoma, primordial cysts, squamous cell carcinoma and odontoma were analyzed by their intra-oral radiographs in the right premolar regions. The radiograms were digitized by the use of a drum scanner densitometry method. The input radiographic images were processed by a histogram equalization method. The result are as follows : First, the histogram equalization method enhances the image contrast of the textures. Second, the output images of the textures for normal mandible-trabeculae radiograms are of network pattern in nature. Third, the output images for the patients are characterized by the non-network pattern and replaced by the patterns of the fabric texture, intertwined plants (karakusa-pattern), scattered small masses and amorphous texture. Thus, these results indicates that the present digital image system is expected to be useful for revealing the texture patterns of the radiographs and in the future for the texture analysis of the clinical radiographs to obtain quantitative diagnostic findings.

  6. Odontogenic lesions in pediatric patients.

    Science.gov (United States)

    Fang, Qi-Gen; Shi, Shuang; Sun, Chang-Fu

    2014-05-01

    The purpose was to evaluate our 20-year experience of pediatric odontogenic lesions. Pediatric patients with a diagnosis of odontogenic lesion were identified. Three hundred ten patients were odontogenic; dentigerous cyst was seen in 62.0% of the cases. Most (70.2%) of them occurred in mixed dentition period, and it had a male preponderance. Odontogenic keratocystic tumor occurred in the permanent dentition period. It had an equal site distribution. Odontoma was seen in 20.0% of the cases. Its site of predilection was the mandible. Ameloblastoma was the most common odontogenic tumor. Most of the cases occurred in the permanent dentition period. It affected the male and female equally. Calcifying epithelioma odontogenic tumor was seen in 11.8% of the cases. All the lesions occurred in the primary dentition period. It had no sex or site preponderance. Myxoma was seen in 3.6% of the cases. It was most common in the permanent dentition period, and it was more frequent in the male. Iliac crest bone graft was successfully performed in 28 patients, postoperative infection occurred in 2 patients, and no donor-site dysfunctions were reported. The observed differences in lesion type and distribution in this study compared with previous researches may be attributable to genetic and geographic variation in the populations studied. Iliac crest bone graft was suggested for pediatric mandible reconstruction. PMID:24785745

  7. Odontogenic tumors: A review of 675 cases in Eastern Libya

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    Saravana HL Goteti

    2016-01-01

    Full Text Available Aims: The aim of this study was to determine the relative frequency of odontogenic tumors (OTs in an Eastern Libyan population based on the 2005 World Health Organization (WHO classification, and also to compare the actual data with previous studies. Materials and Methods: We retrieved and analyzed 85 OTs from a total of 675 tumors and tumor-like lesions of the oral and perioral structures, for gender, age, tumor site, and frequency. The diagnosis was based on the most recent WHO (2005 classification of OTs. Results: OTs constituted 12.6% of all oral/jaw tumors and tumor-like lesions. Ameloblastoma (28.2% was the most common type, followed by keratocystic odontogenic tumor (25.2% and odontoma (19.9%. The male: female ratio was 1.2:1, and maxilla: mandible ratio 1:2. The mean age of occurrence of tumors was 29 years with a peak incidence between 10 and 40 years. Conclusions: OTs are relatively common lesion in this Libyan Population, but the incidence of tumors is neither similar to Caucasians nor Sub-Saharan population.

  8. Prevalence of odontogenic cysts and tumors among UAE population

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    Natheer Hashim Al-Rawi

    2013-01-01

    Full Text Available Background: Odontogenic cysts and tumors are lesions that tend to arise from the tooth apparatus or its remnants. Odontogenic cysts and tumors constitute an important aspect of oral maxillofacial pathology as they can be diagnosed in general dental practice. Aim: The purpose of this study was to evaluate the prevalence of odontogenic cysts and tumors diagnosed in the UAE and to compare the results with findings in the literature. Materials and Methods: Data of odontogenic cysts diagnosed between 1990 and 2010 were collected from the files of the Oral Pathology Laboratory and Oral Surgery Department of Tawam Hospital, UAE. Results: Most of the prevalent odontogenic cysts are radicular cysts (69.1% - followed by dentigerous cysts (7.9%. Among the odontogenic tumors, the most prevalent is odontoma (12.2% followed by ameloblastoma (2.9%. The middle and posterior mandible was the most common anatomic site for the formation of cysts and tumors. In fact, 93.4% of patients over 40 years presented with odontogenic cysts, whereas 6.3% presented with odontogenic tumor. Odontoma as odontogenic tumor was seen mostly in the first and second decades of life. Conclusion: The prevalence of odontogenic cysts was similar to that reported in the literature, with inflammatory cysts occurring most frequently.

  9. A 10-year retrospective study on odontogenic tumors in Iran

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    Nasim Taghavi

    2013-01-01

    Full Text Available Objective: The aim of this study was to review cases of odontogenic tumors diagnosed in two pathology centers in Tehran, Iran, during a 10-year period. Study Design: Patients′ records were seen at two teaching pathology Centre′s of Shahid Beheshti University between the months of March 2000 to 2010 with histologic diagnosis of any type of odontogenic tumors. The records were analyzed for frequency, age, sex, site, as well as clinical, radiographic and histopathologic findings. Results: Of 30706 biopsies, 4767 (15.5% cases were diagnosed as oral and maxillofacial lesions. Among these, 720 cases were tumoral with 188 (26.1% cases of odontogenic tumors. Tumors with odontogenic epithelium origin formed 70.2% of total numbers of odontogenic tumors. Mixed odontogenic tumors and tumors of odontogenic ectomesenchyme comprised 12.2% and 17.5% of the cases respectively. Ameloblastoma, with a frequency of 62.2% was the most common tumor in this review which was followed by odontoma and odontogenic myxoma. Conclusion: Although there are few studies on odontogenic tumors in literature, the comparison of our results with existing data shows significant differences in the distribution of tumors and age of patients, which may be due to ethnic features and geographic distribution of patients. Future studies on other ethnic groups are essential for further clarification of the findings in this research.

  10. Radiological and histopathological study of benign tumors of the mandible

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Seon Young; Baek, Seung Yon; Choi, Kyung Hee; Suh, Jeung Soo; Rhee, Chung Sik; Kim, Hee Seup [Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    1984-06-15

    Benign tumors of the mandible are uncommon lesions. That were classified into odontogenic tumors and nonodontogenic tumors. Author reviewed the radiological evaluation and pathological microscopic finding from 33 benign tumors of the mandible that were confirmed by the biopsy during last 10 years in Dental Clinics, Ewha Womans University Hospital and Seoul National University Dental Hospital. Following results were obtained; 1. Benign tumors of the mandible were classified into odontogenic (66.7%) and non-odontogenic tumors (33.3%). 2. The range of the age distribution was between 6 years and 67 years old. The commonest age group was the second decade (39.4%). 3. There was no difference to sex distribution. 4. The most frequent location was the body of the mandible (42.4%). 5. Radiographic findings were relatively characteristic in odontogenic tumors rather than non-odontogenic tumors. 1) Radiolucent cystic lesions-ameloblastoma, odontogenic myxoma, odontogenic fibtoma, aneurysmal bone cyst and neurofibroma. 2) Radiopaque mass lesions-odontoma, cementoma and osteoma. 3) Mixed patterns-ossifying fibroma, cementifying fibroma, calcifying odontogenic epithelial tumor and hemangioma. It was concluded that the radiographic examination was of value to diagnose the benign tumors of the mandible in symptomless patients.

  11. Molecular Characterization of Clear Cell Lesions of Head and Neck.

    Science.gov (United States)

    Jain, Anshi; Shetty, Devi Charan; Juneja, Saurabh; Narwal, Nidhi

    2016-05-01

    The salivary glands, oral mucosa and jaws constitute a group of lesions which are heterogeneous in nature and are odontogenic, salivary or metastatic in origin. This group of tumours is termed as Clear Cell Tumours. Fixation artifacts are one of the most important reasons for the cell to appear clear but clearing of cells may also result from cytoplasmic accumulation of water, presence of glycogen within the cell, intermediate filaments, immature zymogen granules, or a paucity of cellular organelles. Clear cell Odontogenic neoplasms predominantly include odontogenic carcinoma, ameloblastoma and calcifying epithelial odontogenic tumour. Clear cell tumours of salivary gland origin are almost invariably malignant in nature but they do include two benign lesions. Very frequently, surgical pathologist encounters clear cells in many malignant neoplasms, the nature and sources of which are undetermined on the basis of conventional histopathology. This review will selectively discuss the clinicopathological features of neoplasms which at times may pose a diagnostic challenge and dilemma due to clear cell changes. PMID:27437379

  12. Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil

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    Grasieli de Oliveira Ramos

    2014-01-01

    Full Text Available Odontogenic tumors (OTs are lesions that develop exclusively on maxillary bones, and form a heterogeneous group. They vary from hamartomatous lesions to benign and malign tumors. Although they are rarely observed in dentistry clinics, it is extremely important for the dentist to be aware of them. The aim of this study was to investigate the incidence of odontogenic tumors diagnosed in the population of Florianópolis, Santa Catarina, Brazil. Cases of odontogenic tumors were selected from the anatomopathological diagnostic services at Federal University of Santa Catarina from 1998 to 2011. Clinical data on these cases were collected from biopsy reports and patient files. Seventy-eight cases of odontogenic tumors were surveyed. Of these diagnoses, 51% were keratocystic odontogenic tumors (KCOTs; the remaining cases were mainly ameloblastomas and odontomas. The most frequently observed lesion in this retrospective study was KCOT (more than half of cases. Thus, this study shows that modifying the classification of the OTs altered the frequency of the lesions, possibly making KCOT the most common lesion observed in diagnostic services worldwide.

  13. A study on the mixed jaw lesions associated with teeth

    Energy Technology Data Exchange (ETDEWEB)

    Nah, Kyung Soo [Dept. of Dental Radiology, College of Dentistry, Pusan National University, Pusan (Korea, Republic of)

    2000-03-15

    1. Retrospectively evaluate the accuracy of tentative diagnosis or impression from the clinico-radiographic materials of jaw lesions which showed mixed lesions associated with teeth. 2. To observe the diagnostic importance of the calcified part of the lesions which appear as radiopaque areas. 14 cases of jaw lesions which showed mixed lesions associated with teeth were reviewed. These lesions were mostly diagnosed as adenomatoid odontogenic tumors (6 cases) or calcifying odontogenic cysts with (4 cases) or without odontomas (4 cases). The calcified elements of the lesions which demonstrated various sizes and patterns of radiopaque shadows resembled odontoid tissues in some cases but could not be defined in some other cases radiographically. The final histopathologic diagnosis confirmed adenomatoid odontogenic tumors in 4 of the 6 cases. The remaining 2 cases turned out to be odontoma and ameloblastic fibroodontoma. The 4 cases of calcifying odontogenic cysts with odontomas were correct in 3 cases but remaining 1 case was just odontoma. The 4 cases of calcifying odontogenic cysts were proved to be odontogenic keratocyst, calcified peripheral fibroma, unicystic ameloblastoma and squamous cell carcinoma. The diagnostic accuracy of the adenomatoid odontogenic tumors and calcifying odontogenic cysts were high when the lesions show typical appearance. The calcifications which show radiopaque areas could be odontomas or dystrophic calficifations or remnants of bone fragments from resorption.

  14. Molecular markers of cancer in cartilaginous fish: immunocytochemical study of PCNA, p-53, myc and ras expression in neoplastic and hyperplastic tissues from free ranging blue sharks, Prionace glauca (L.).

    Science.gov (United States)

    Borucinska, J D; Schmidt, B; Tolisano, J; Woodward, D

    2008-02-01

    Archival formalin-fixed tissues from wild-caught adult blue sharks, Prionace glauca (L.), were used for immunocytochemical detection of proliferating cell nuclear antigen (PCNA), two oncoproteins from the oncogenes c-myc and pan-ras, and a protein product from the tumour suppressor gene p-53. All sharks were caught during summer months between 2000 and 2006 by recreational fishermen off the USA coast in the northwestern Atlantic. The sharks were necropsied on landing and selected organ samples were collected into elasmobranch formalin and processed for paraffin embedding and light microscopy. Paraffin-embedded sections from collected tissue were both stained with haematoxylin and eosin and processed by immunocytochemical techniques using antibodies raised against the PCNA, p-ras, c-myc and p-53 proteins. The lesions examined in this study included two well differentiated adenomatous gastric polyps, a testicular capsular mesothelioma, a gingival fibropapilloma with elements of ameloblastoma, three liver tumours, two pericardial fibropapillomas and six cases of proliferative serositis (pericarditis and peritonitis). Normal and hyperplastic tissues from blue sharks, and human neoplastic tissues served as negative and positive controls, respectively. We detected upregulation of PCNA in many neoplastic, one dysplastic and in some hyperplastic lesions, and positive p-ras and c-myc signals in some of the neoplastic lesions. None of the examined tissues showed positive p-53 signalling. This is the first literature report on immunocytochemical detection of molecular markers of cancer in sharks and in fish of the class Chondrichthyes. PMID:18234018

  15. Occurrence of bone cancer among young adult Beagles given 239Pu

    International Nuclear Information System (INIS)

    Two hundred thirty-five young adult Beagles of both sexes were each given a single intravenous injection of 239Pu-citrate at graded dose-levels averaging about 0.026 to 106 kBq/kg when they were about 1 1/2 years of age and were maintained for lifespan observation. An additional 133 young adult Beagles of both sexes were entered into the experiment as control animals. All of these animals have now died or have been removed from the colony, and the occurrence of skeletal malignancies has been determined from histological examination. There were a total of 85 radiographically apparent malignant bone tumors in 77 dogs given 239Pu, and there was one control animal that developed a skeletal malignancy. Most of these were osteosarcomas, but there were seven chondrosarcomas of bone, one liposarcoma of bone, and in addition, there was one plasma cell myeloma and one ameloblastoma (admantinoma). Only those dogs that survived to at least the minimum latent period for death with radiation-induced bone sarcoma are included in the tabulation. There appeared to be a linear relationship between the percent of dogs with bone tumor and the average skeletal dose up to a dose of about 1 Gy. All dose-levels with skeletal doses of about 2 Gy and greater exhibited close to 100% occurrence

  16. A study on the mixed jaw lesions associated with teeth

    International Nuclear Information System (INIS)

    1. Retrospectively evaluate the accuracy of tentative diagnosis or impression from the clinico-radiographic materials of jaw lesions which showed mixed lesions associated with teeth. 2. To observe the diagnostic importance of the calcified part of the lesions which appear as radiopaque areas. 14 cases of jaw lesions which showed mixed lesions associated with teeth were reviewed. These lesions were mostly diagnosed as adenomatoid odontogenic tumors (6 cases) or calcifying odontogenic cysts with (4 cases) or without odontomas (4 cases). The calcified elements of the lesions which demonstrated various sizes and patterns of radiopaque shadows resembled odontoid tissues in some cases but could not be defined in some other cases radiographically. The final histopathologic diagnosis confirmed adenomatoid odontogenic tumors in 4 of the 6 cases. The remaining 2 cases turned out to be odontoma and ameloblastic fibroodontoma. The 4 cases of calcifying odontogenic cysts with odontomas were correct in 3 cases but remaining 1 case was just odontoma. The 4 cases of calcifying odontogenic cysts were proved to be odontogenic keratocyst, calcified peripheral fibroma, unicystic ameloblastoma and squamous cell carcinoma. The diagnostic accuracy of the adenomatoid odontogenic tumors and calcifying odontogenic cysts were high when the lesions show typical appearance. The calcifications which show radiopaque areas could be odontomas or dystrophic calficifations or remnants of bone fragments from resorption.

  17. Fractura mandibular patológica por plasmocitoma intraóseo Pathological mandibular fracture due to intraosseous plasmacytoma

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    D. Antunes Freitas

    2012-06-01

    Full Text Available Los tumores de células plasmáticas se subclasifican en: Plasmocitomas solitarios de hueso, mieloma múltiple y plasmocitoma extramedular. El 80 % de estos últimos afecta la región de la cabeza y cuello surgiendo en el tejido blando del conducto respiratorio alto y, raras veces, en la cavidad bucal. La búsqueda de una enfermedad sistémica es importante es aquellos casos en los que se haga dicho diagnóstico. Se presenta el caso de un paciente, varón de 73 años de edad, residente en la localidad rural de Gran Mogol, en Minas Gerais (Brasil, La tomografía computarizada mostró hipodensidad y reabsorción osteolítica irregular en la base de la cresta alveolar mandibular izquierda. La lesión de medición 38,0×19,0×15,0 mm. En la TC se ve claramente la presencia de fractura patológica del lado izquierdo. La aspiración con aguja se realizó, donde se obtuvo sangre. Se realizó la biopsia incisional. El diagnóstico presuntivo fue ameloblastoma. La muestra de biopsia fue enviada para análisis anatomohistopatológica. La microscopía mostró células tumorales compuesto por células monomórficas, con núcleos ovalados, grandes periféricos, y excéntricos, nucléolos prominentes y citoplasma basófilo, rodeado por estroma escaso y la infiltración de hueso esponjoso. La prueba de orina se destinó específicamente a la proteína de Bence-Jones, que fue negativo. Las radiografías de cráneo y tórax fueron realizados y no mostró cambios. Luego completó un diagnóstico de Plasmocitoma solitario en la mandíbula. El paciente está sometido a radioterapia en el Servicio de Oncología de la Santa Casa de Misericordia. El paciente tuvo mucositis severa y cambios en el color facial como resultado de la radioterapia.Plasma cell tumors are subclassified into: Solitary plasmacytoma of bone, multiple myeloma and extramedullary plasmacytoma. 80% of the latter affects the region of the head and neck soft tissue arising in the upper respiratory

  18. Stafne kemik kavitesi: 3 olgu sunumu

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    Secil Nigar Karadeniz

    2012-01-01

    Full Text Available

    Stafne bone cavities (SBC, which arise mandible angulus among third molar teeth, are round or ovoid-shaped, well-circumscribed, uniloküler and radiolucent lesions. Despite a wide age range seen, in men, 5. and 6. decades seen more. The differential diagnosis of traumatic bone cyst, ossifying fibroma, benign lesions such as florid osseous dysplasia and malignant lesions such as ameloblastoma done. Supporting imaging modalities such as sialography, computerised tomography (CT, magnetic resonance imaging (MRI should be used for differantial diagnosis. The aim of this case report was to higlight the use sialography and computered tomography (CT for detecting stafne bone cavity (SBC and to differenciate other radiographic appearance such as cystic lession in the jaws.

     

    ÖZET

    Stafne kemik kaviteleri (SKK, mandibula angulusu ile 3. molar dişler arasında izlenen  yuvarlak veya ovoid şekilli, iyi sınırlı, uniloküler ve radyolüsent görüntü veren lezyonlardır. Görülme yaşı çok geniş bir aralığa sahip olmasına rağmen, erkeklerde 5. ve 6. dekatlarda daha fazla görülmektedir. Ayırıcı tanısı travmatik kemik kisti, ossifiye fibroma ve florid osseoz displazi gibi bening lezyonların yanı sıra ameloblastoma gibi malign lezyonlarla yapılmaktadır. Ayırıcı tanıda sialografi, bilgisayarlı tomografi (BT veya magnetik rezonans görüntüleme (MRG gibi destekleyici görüntüleme yöntemlerinden yararlanılmalıdır. Bu olgu sunumunda, sialografi ve bilgisayarlı tomografi (BT  tekniğinin stafne kemik kavite (SKK görüntüsünün belirlenmesi ve çenelerde görülen diğer kistik görüntülerle ayırıcı tanıda kullanılmasının önemi değerlen-dirilmektedir.

  19. EXPRESSION AND SIGNIFICANCE OF bcl-2 FAMILY IN AMELOBLASTONA

    Institute of Scientific and Technical Information of China (English)

    WANG Jie; MA Jie; ZHONG Ming; LIU Jing-dong

    2006-01-01

    Objective: To study the expression of bcl-2 and bax in human ameloblastoma (AB), and investigate the role of apoptosis in genesis and development of AB and the relation of apoptosis with the clinic biological characteristics of AB. Methods:BCL-2 and BAX proteins were detected in 75 cases of AB (primary AB 31 cases, recurrent AB 37 cases, malignant AB 7cases) by S-P method. Oral normal mucosa (NOM) and Odontogenic kerotosyst (OKC) were used as controls. Bcl-2 and bax mRNA in 20 cases of AB, 12 cases of OKC were detected by in situ hybridization. Results: The positive ratio of BCL-2protein was 88.0% ( 66/75 ) in AB, 74.3% (26/35) in OKC and 44.4% (4/9) in NOM, respectively (P<0.001). BCL-2 protein was expressed in peripheral cells and a few scattered stellate-shape cells in AB. The positive ratio of BAX protein was 74.7%(56/75)in AB, 65.7%(23/35)in OKC and 77.8%(7/9) in NOM, respectively (P<0.001). BAX protein was expressed in peripheral cells and stellate-shape cells with similar intensity. BCL-2 expression increased in recurrent and AB canceration(P<0.01), while for BAX expression, the positive ratio was higher in recurrent AB, but lower than that of malignant AB. A moderate negative correlation between BCL-2 and BAX protein was found (rk=-0.331, P<0.001).Conclusion: AB has much more apoptosis-inhibiting protein than apoptosis- accelarating protein. Apoptosis plays an important role in genesis, development of AB. The fashion and intensity of bcl-2 and bax expression were different in various tissues and in benign or malignant AB.

  20. Primordial Odontogenic Cyst with Induction Phenomenon (Zonal Fibroblastic Hypercellularity) and Dentinoid Material Versus Archegonous Cystic Odontoma: You Choose!

    Science.gov (United States)

    Argyris, Prokopios P; Wetzel, Stephanie L; Pambuccian, Stefan E; Gopalakrishnan, Rajaram; Koutlas, Ioannis G

    2016-06-01

    The most recent A.F.I.P. fascicle defines primordial odontogenic cyst (POC) as a distinct, nonkeratinized, odontogenic cyst of "undetermined origin" forming in the place of a developing normal or supernumerary tooth. However, the majority of examples reported in the literature under this term represent odontogenic keratocysts (keratocystic odontogenic tumors). In addition, there are rare reported cases of cystic odontomas. An 18-year-old Caucasian male presented with a unilocular mandibular radiolucent lesion in the place of a congenitally missing molar. Histologically, it featured nonkeratinizing, thin stratified squamous epithelial lining with areas of spongiosis and foci of vacuolization of individual basal cells without significant nuclear palisading. Focally, budding of the basal cell layer was identified. A zone of increased cellularity featuring induction-type fibroblasts was present subepithelially as well as dentinoid deposits with odontogenic epithelial nests. Immunohistochemically, the epithelial lining was negative for calretinin and the induction-like zone negative for S100 protein, smooth muscle actin, and CD34. The case was externally reviewed by five oral pathologists who provided various diagnostic interpretations including primordial cyst, odontogenic cyst not otherwise specified (NOS), cyst with ameloblastic changes, and unicystic ameloblastoma. At that time, a final diagnosis of odontogenic cyst NOS was rendered with a comment that it may represent a true example of POC or a cystic odontoma. The lesion has not recurred within a 13 year follow-up period after initial excision. An unusual cystic lesion is presented that may represent a true example of POC with dentinoid formation or an archegonous cystic odontoma. PMID:26156422

  1. A review of 156 odontogenic tumours in Calabar, Nigeria

    International Nuclear Information System (INIS)

    Odontogenic tumours occur in our environment and because of late treatment, cause considerable disabilities. The objective of this study is to review a baseline data for the Dental and Maxillofacial Clinic, University of Calabar Teaching Hospital, Nigeria in order to obtain a baseline data and subsequently compare the results with that obtained elsewhere. Using the hospitals case files and register of patients, a 5-year retrospective study of odontogenic tumours at the teaching hospital was carried out. The data documented include age, gender, duration of lesion, type of tumour, socio-economic class, type of surgery, and complaints during follow-up reviews. The results of the study showed that majority of the patients (n=49, 31.4%) were in the third decade of life. There were 85 (54.5%) males and 71 (45.5%) females, giving male to female ratio of 1.2:1. There was a significant association between the type of odontogenic tumour and the age of occurrence (p=0.000). The longer the duration of symptoms before presentation, the larger the tumours (p=0.000). The longer the duration of symptoms before presentation, the larger the tumours (p=0.000). The benign odontogenic tumours were 151 (96.8%), ameloblastoma (n=74, 47.4%) being the commonest. Jaw resection (54.5%) was the predominant treatment. Majority (58.0%) of the complications following treatment were facial deformity, malocclusion and impaired mastication. Majority of the patients was in the lower socio-economic class, presented late for treatment and a few with aesthetic and functional impairment returned for secondary surgery. The intervention of agencies of government and non-governmental organizations is required to assist these patients if we are to accomplish the core healthcare system values in our environment. (author)

  2. Indications and outcome of mandibular condylar and ramus surgeries

    Directory of Open Access Journals (Sweden)

    Babatunde O Akinbami

    2014-01-01

    Full Text Available Background: Different surgical procedures are utilized for treatment of various diseases of the posterior mandible depending on the type of disease, site, duration and age of the patient. A thorough knowledge of the anatomical relations of structures and adequate surgical skills are needed to minimize complications. The purpose of this study was to evaluate the indications and outcome of surgical techniques for diseases affecting the condyle and ramus of the mandibles. Patients and Methods: Data were retrieved from the case files of patients who had surgeries for diseases involving the ramus/condylar area of the mandible. The diagnosis/indications for surgery, procedure and postoperative outcomes were documented. Outcomes assessed were related to mouth opening, esthetics (appearance of scar and jaw symmetry and function (occlusion, Jaw movements. Complications such as nerve dysfunction were documented. Paresthesia was tested by simple tactile stimulations. Results: There were a total of 27 procedures done either on the condyle or ramus in 23 (100% patients between May 2006 and October, 2013. 16 procedures were done for tumors in 16 (69.6% patients, 14 (60.9% patients had Ameloblastoma, 1 (4.3% had central neurofibroma and one had keratocystic odontogenic tumor, two procedures for unilateral condylar fractures in 2 (8.6% patients, five procedures for ankylosis in 3 (13.0% patients and four procedures were done for dislocation in 2 (8.6% patients. There was no permanent nerve dysfunction; mouth opening, jaw movements and mastication were remarkably satisfactory. Conclusion: Esthetic and functional outcome were quite satisfactory when compared with the preoperative status.

  3. Clinical features and treatment of ameloblastic fibro-odontoma%成釉细胞纤维牙瘤的临床特点及治疗

    Institute of Scientific and Technical Information of China (English)

    徐峰; 王炳超; 孔丽; 王科; 贾暮云; 袁荣涛

    2016-01-01

    Ameloblastic fibro-odontoma ( AFO) is a rare odontogenic tumor. It often occurrs at the age under twenty, male more than in female. It is mostly located in the maxilla and mandible, and more common in the mandible. It grows slowly with no symptoms. There is asymptomatic swelling in the maxillofacial region and it delays tooth eruption in the case with AFO. X-ray examination always shows a cystic cavity in the jaw, with clear boundary. It is not easy to be differentiated from odontogenic tumors, such as ameloblas-toma and keratocystic odontogenic tumor. Pathological examination shows that neoplasm was composed of proliferating odontogenic epi-thelium in a cellular ectomesenchymal tissue, similar to ameloblastic fibroma in form. Hard tissue component is similar to odontoma, dental structures resembling dentine and enamel-like tissues. It has a low probability of malignancy. The most common treatment is sur-gical removal with low potential for recurrence. In this paper, one case with ameloblastic fibro-odontoma was reported and the clinical features and treatment of ameloblastic fibro-odontoma were investigated.%成釉细胞纤维牙瘤是一种少见的牙源性肿瘤,多发生于20岁以下,男性多于女性,上下颌骨均可发生,多发生于下颌骨,生长缓慢,无自觉症状,常表现为颌面部的肿胀、牙齿迟萌.X线片常见单房改变,表现为边界清楚的囊性透射影,不易与牙源性肿瘤鉴别.组织学表现,软组织成分为牙源性上皮和胚胎性的结缔组织,类似成釉细胞纤维瘤的形态,硬组织成分为牙本质、釉质样组织,类似牙瘤.恶变可能性低,治疗方式为手术摘除,一般不易复发.该文结合我科收治的成釉细胞纤维牙瘤病例,探讨成釉细胞纤维牙瘤的临床特点及治疗与预后.

  4. Prevalencia de tumores odontogénicos en el Hospital Base Valdivia: periodo 1989-2008

    Directory of Open Access Journals (Sweden)

    L.C. Thiers

    2013-12-01

    Full Text Available Objetivo: Este artículo corresponde a un estudio observacional de tipo descriptivo de corte transversal, tiene como objetivo determinar la prevalencia de tumores odontogénicos en la población atendida en el Hospital Base Valdivia, en un periodo de 20 años (1989-2008, según la nueva clasificación de lesiones tumorales de la WHO, 2005. Metodología: Se revisaron 2.078 informes de biopsias correspondientes a lesiones de la cavidad oral de los archivos de informes del servicio de Anatomía Patológica, Hospital Base Valdivia entre enero del año 1989 y diciembre del año 2008. Como criterios de inclusión están la presencia de un diagnóstico histopatológico en la ficha y legibilidad de ésta. Las variables a analizar incluyen: edad, género, diagnóstico histopatológico, tipo de tumor y área de localización. Los datos recolectados fueron tabulados en planilla de base de datos, para su posterior análisis estadístico. Resultados: De las 2.078 biopsias del territorio bucal, 31 corresponden a tumores odontogénicos, lo que representa un 1,5% de todas las lesiones biopsiadas del territorio oral. Una lesión maligna fue encontrada y corresponde a carcinoma ameloblástico infiltrante. La lesión más frecuente correspondió a tumor odontogénico queratoquístico (41,9%, seguido por el ameloblastoma (22,6% y, por último, odontoma (16,1%. El promedio de edad de 35,7 años. El área más frecuente de presentación es el área molar mandibular (54,8%. Conclusión: Los tumores odontogénicos son de baja prevalencia en la población valdiviana atendida en el Hosptial Base Valdivia entre los años 1989-2008. No tiene predilección por género. La lesión más prevalente es el tumor odontogénico queratoqísitico.

  5. A statistical study of the maxillofacial diseases by radiograms

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yoo Tai; Lee, Sang Chull [College of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    1974-11-15

    This report based on 300 cases of serious diseases in maxillofacial region by radiograms seen at the department of dental radiodontics, infirmary school of dentistry, Kyung Hee University from October 1971 to August 1974. The maxillofacial diseases were analysed upon the following items, such as 1) the frequency of dominant diseases, 2) sex-ratio of male to female, 3) predominant region of diseases, 4) comparison with the age, 5) the incidence of diseases in relative to the individual teeth. The results were obtained as follows. 1) Among the total of 300 cases of the patients, the frequency of dominant diseases of patients were fractures of facial bone (44.3 {+-} 2.87%), inflammatory diseases (22.7 {+-} 2.39%), cysts (11.1 {+-} 1.62%), tumors(10.7 {+-} 1.77%), maxillary sinusitis (7.9 {+-} 1.56%), temporomandibular joint disorders(3.3 {+-} 1.05%) in the order. 2) The sex ratio of male to female in occurrence of jaw fractures were 7.3 : 1, temporomandibular joint disorders were 2.1 : 1, inflammatory diseases were 1.8:1, maxillary sinusitis were 1.7 : 1, but tumors were 1: 1, while cysts were 1:1 .2 in sex difference.3) The predominant region of mandibular fractures were symphysis (17.3 {+-} 3.27%), canine region (15.0 {+-} 3.09%), and angle region(14.3 {+-} 3.04%) in the order. Inflammatory diseases were occurred frequently in mandible and it's left side were a little dominant. Odontogenic cysts were observed frequently in maxilla, but regardless of right and left. Carcinomas were involved most frequently in maxilla, while sarcomas and ameloblastomas in mandible. Frequency of the maxillary sinusitis w ere dominant in right side and molar area, also temporomandibular joint disorders were dominant in right side. 4) To study comparing with the age, jaw fractures showed the highest ratio at the 2nd decade (32.3 {+-} 4.06%), and 3rd decade (27.8 {+-} 3.89%), 4th decade (19.6 {+-} 3.44%), 6th decade (9.0 {+-} 2.47%), 5th decade(6.0 {+-} 2.06%), lst decade(5.3 {+-} 1

  6. A statistical study of the maxillofacial diseases by radiograms

    International Nuclear Information System (INIS)

    This report based on 300 cases of serious diseases in maxillofacial region by radiograms seen at the department of dental radiodontics, infirmary school of dentistry, Kyung Hee University from October 1971 to August 1974. The maxillofacial diseases were analysed upon the following items, such as 1) the frequency of dominant diseases, 2) sex-ratio of male to female, 3) predominant region of diseases, 4) comparison with the age, 5) the incidence of diseases in relative to the individual teeth. The results were obtained as follows. 1) Among the total of 300 cases of the patients, the frequency of dominant diseases of patients were fractures of facial bone (44.3 ± 2.87%), inflammatory diseases (22.7 ± 2.39%), cysts (11.1 ± 1.62%), tumors(10.7 ± 1.77%), maxillary sinusitis (7.9 ± 1.56%), temporomandibular joint disorders(3.3 ± 1.05%) in the order. 2) The sex ratio of male to female in occurrence of jaw fractures were 7.3 : 1, temporomandibular joint disorders were 2.1 : 1, inflammatory diseases were 1.8:1, maxillary sinusitis were 1.7 : 1, but tumors were 1: 1, while cysts were 1:1 .2 in sex difference.3) The predominant region of mandibular fractures were symphysis (17.3 ± 3.27%), canine region (15.0 ± 3.09%), and angle region(14.3 ± 3.04%) in the order. Inflammatory diseases were occurred frequently in mandible and it's left side were a little dominant. Odontogenic cysts were observed frequently in maxilla, but regardless of right and left. Carcinomas were involved most frequently in maxilla, while sarcomas and ameloblastomas in mandible. Frequency of the maxillary sinusitis w ere dominant in right side and molar area, also temporomandibular joint disorders were dominant in right side. 4) To study comparing with the age, jaw fractures showed the highest ratio at the 2nd decade (32.3 ± 4.06%), and 3rd decade (27.8 ± 3.89%), 4th decade (19.6 ± 3.44%), 6th decade (9.0 ± 2.47%), 5th decade(6.0 ± 2.06%), lst decade(5.3 ± 1.95%) in the order. But 7th decade

  7. Reconstruction of mandible with fibular flap and dental implant distractor: a new approach%颌骨内置式牵引种植体在腓骨游离皮瓣重建下颌骨中的应用

    Institute of Scientific and Technical Information of China (English)

    张陈平; 张志愿

    2002-01-01

    Objective To study the application of dental implant distractor (DID) in mandibular functional reconstruction. Methods We designed a new device named DID, which includes the permanent dental implant and the temporary distractor in itself. It is specially designed for fibula wider distraction in mandible reconstruction. Twenty-five sets of DID devices were put into 8 patients (6 men and 2 women) during operation. Two patients suffered from ameloblastoma of the mandible, 2 from odontogenic cyst of the mandible, 1 from fibrous dysplasia, and the other 3 from malignant tumor of the mandible. The age of 8 patients ranged from 19 to 67 (mean 46.8) years. Results During postoperative 2-15 months follow up, 7 patients were found to be successful. The clinical examination and X-ray film showed the normal shape of the mandible and the osteointegration of the implants were solid enough to withstand the denture force. Others had the DID removed because of inflammation. Two of the patients successfully worn the fixed dental prosthesis. The outcomes was satisfying. Conclusion The DID device specially designed for mandibular reconstruction with fibular flap can help to simplify convenient procedures to a single surgery.%目的探讨颌骨内置式牵引种植体(DID)在下颌骨功能重建中的应用.方法我们设计了包含永久种植体和暂时性牵引器的牵引种植体.此牵引器特别为腓骨垂直牵引重建下颌骨缺损而设计.共完成8例下颌骨缺损重建(25个DID),其中2例成釉细胞瘤,2例下颌骨囊肿,1例骨纤维异常增殖症,其余3例为恶性肿瘤(6例男性,2例女性).结果随访2-15个月, 7例患者治疗成功,临床检查及X线检查示正常下颌骨外形及种植体良好的骨结合.1例患者出现局部感染,取出2个牵引种植体.2例患者完成义齿修复.结论颌骨内置式牵引种植体可用于下颌骨功能性重建,种植体植入与牵引同期完成缩短了手术周期.

  8. Application of scapula osteomyocutaneous flap in the repair of maxillary defect%肩胛骨肌皮瓣在上颌骨缺损修复的初步应用

    Institute of Scientific and Technical Information of China (English)

    吴跃煌; 李德志; 王晓雷; 徐震纲

    2015-01-01

    Objective Preliminary study on free scapula osteomyocutaneous flap to repair maxillary defect.Methods Central maxillofacial soft and hard tissue defect after nasal sinus or oral tumor surgery was repaired with free scapual osteomyocutaneous flap in 4 patients to reconstruct their maxillofacial functions.The primary tumors included an ameloblastoma, a recurrent low-grade mucous epidermoid carcinoma a jaw sarcoma and a squamous cell carcinoma.Results All the 4 cases had good wound healing within 2 weeks after surgery, with no complications, could take in semifluid food after 3 weeks, and had clear language communication after 1 month.Three cases wore denture after 2 months and recovered maxillofacial contour and partial chewing function, and had no tumor recurrences with the follow-up of 37, 25 and 10 months respectively.One case of maxilla sarcomas had recurrence with invasion of parapharyngeal space and skull base and pulmonary metastasis 9 months after surgery, who gave up further treatment and died 1 year later.No obvious dysfunction occurred in shoulder and back donation sites and well blood supply in transplanted bones were showed with CT and bone scan.Conclusions Scapula osteomyocutaneous flap has some advantages including reliable blood supply, hidden incision and little affect on the donation site, and it can apply with multiple tissues including bone, muscle, and skin for repair.This flap also has good shape adaptability and availability.So scapula osteomyocutaneous flap is a satisfactory method for the repair of facial maxillary complex defects.But some limitations exist in the flap, by which less amount of bone can be applied and more operation time is required due to the changes of patient's body position during surgery.%目的 对采用游离肩胛骨肌皮瓣修复上颌骨缺损进行初步探讨.方法 选择因鼻窦或口腔肿瘤需行外科手术,将导致颌面中部软、硬组织缺损,严重影响功能需要修复的4例患者,其中造釉