WorldWideScience

Sample records for alternative approaches volume

  1. A finite volume alternate direction implicit approach to modeling selective laser melting

    DEFF Research Database (Denmark)

    Hattel, Jesper Henri; Mohanty, Sankhya

    proposed for modeling single-layer and few-layers selective laser melting processes. The ADI technique is implemented and applied for two cases involving constant material properties and non-linear material behavior. The ADI FV method consume less time while having comparable accuracy with respect to 3D...... accurately simulate the process, are constrained by either the size or scale of the model domain. A second challenging aspect involves the inclusion of non-linear material behavior into the 3D implicit FE models. An alternating direction implicit (ADI) method based on a finite volume (FV) formulation is......Over the last decade, several studies have attempted to develop thermal models for analyzing the selective laser melting process with a vision to predict thermal stresses, microstructures and resulting mechanical properties of manufactured products. While a holistic model addressing all involved...

  2. A finite volume alternate direction implicit approach to modeling selective laser melting

    DEFF Research Database (Denmark)

    Hattel, Jesper Henri; Mohanty, Sankhya

    2013-01-01

    phenomena is yet to emerge, the existing partial models have already become computationally heavy. This is observed to go hand-in-hand with a trend across literature for the usage of finite element (FE) formulations for developing implicit 3D models. However, the 3D implicit FE models, though able to...... accurately simulate the process, are constrained by either the size or scale of the model domain. A second challenging aspect involves the inclusion of non-linear material behavior into the 3D implicit FE models. An alternating direction implicit (ADI) method based on a finite volume (FV) formulation is...... proposed for modeling single-layer and few-layers selective laser melting processes. The ADI technique is implemented and applied for two cases involving constant material properties and non-linear material behavior. The ADI FV method consume less time while having comparable accuracy with respect to 3D...

  3. Human factors evaluation of teletherapy: Identification of problems and alternative approaches. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Henriksen, K.; Kaye, R.D.; Jones, R. [Hughes Training, Inc., Falls Church, VA (United States); Morisseau, D.S.; Serig, D.I. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Systems Technology

    1995-07-01

    A series of human factors evaluations was undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multi-disciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. The principal sources of radiation are a radioactive isotope, typically cobalt60 (Co-60), or a linear accelerator device capable of producing very high energy x-ray and electron beams. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of user-system interfaces, procedures, training and qualifications, and organizational policies and practices. The final phase of the project focused on identification of the most significant human factors problems with respect to safe and effective operation of the teletherapy system and an identification and assessment of alternative approaches for resolving the problems. This report presents the findings of this final phase.

  4. Human factors evaluation of teletherapy: Identification of problems and alternative approaches. Volume 1

    International Nuclear Information System (INIS)

    A series of human factors evaluations was undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multi-disciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. The principal sources of radiation are a radioactive isotope, typically cobalt60 (Co-60), or a linear accelerator device capable of producing very high energy x-ray and electron beams. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of user-system interfaces, procedures, training and qualifications, and organizational policies and practices. The final phase of the project focused on identification of the most significant human factors problems with respect to safe and effective operation of the teletherapy system and an identification and assessment of alternative approaches for resolving the problems. This report presents the findings of this final phase

  5. Alternative approaches in IVF

    OpenAIRE

    Fauser, Bart; Bouchard, P.; Coelingh Bennink, H.J.; Collins, John; Devroey, P.; Evers, Johannes; Van Steirteghem, A

    2002-01-01

    textabstractVarious new developments in clinical and basic science which may impact on IVF in the near or distant future will be discussed in this review. These key areas include the regulation of early follicle development and the extended in-vitro culture of oocytes and embryos. Moreover, alternative compounds and ovarian stimulation protocols will be discussed, along with highlights in the development of the cryopreservation of excess oocytes or embryos. Finally, the health economics of IV...

  6. FMDP reactor alternative summary report: Volume 4, Evolutionary LWR alternative

    International Nuclear Information System (INIS)

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] have become surplus to national defense needs both in the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. The purpose of this report is to provide schedule, cost, and technical information that will be used to support the Record of Process (ROD). Following the screening process, DOE/MD via its national laboratories initiated a more detailed analysis activity to further evaluate each of the ten plutonium disposition alternatives that survived the screening process. Three ''Alternative Teams,'' chartered by DOE and comprised of technical experts from across the DOE national laboratory complex, conducted these analyses. One team was chartered for each of the major disposition classes (borehole, immobilization, and reactors). During the last year and a half, the Fissile Materials Disposition Program (FMDP) Reactor Alternative Team (RxAT) has conducted extensive analyses of the cost, schedule, technical maturity, S ampersand S, and other characteristics of reactor-based plutonium disposition. The results of the RxAT's analyses of the existing LWR, CANDU, and partially complete LWR alternatives are documented in Volumes 1-3 of this report. This document (Volume 4) summarizes the results of these analyses for the ELWR-based plutonium disposition option

  7. 18 CFR 281.304 - Computation of alternative fuel volume.

    Science.gov (United States)

    2010-04-01

    ... alternative fuel volume. 281.304 Section 281.304 Conservation of Power and Water Resources FEDERAL ENERGY... Determination § 281.304 Computation of alternative fuel volume. (a) General rule. For purposes of § 281.208(b)(1)(i)(B), and § 281.305: (1) Alternative fuel volume of an essential agricultural user is equal to...

  8. Ironmaking Process Alternative Screening Study, Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Lockwood Greene, . .

    2005-01-06

    Iron in the United States is largely produced from iron ore mined in the United States or imported from Canada or South America. The iron ore is typically smelted in Blast Furnaces that use primarily iron ore, iron concentrate pellets metallurgical coke, limestone and lime as the raw materials. Under current operating scenarios, the iron produced from these Blast Furnaces is relatively inexpensive as compared to current alternative iron sources, e.g. direct iron reduction, imported pig iron, etc. The primary problem the Blast Furnace Ironmaking approach is that many of these Blast furnaces are relatively small, as compared to the newer, larger Blast Furnaces; thus are relatively costly and inefficient to operate. An additional problem is also that supplies of high-grade metallurgical grade coke are becoming increasingly in short supply and costs are also increasing. In part this is due to the short supply and costs of high-grade metallurgical coals, but also this is due to the increasing necessity for environmental controls for coke production. After year 2003 new regulations for coke product environmental requirement will likely be promulgated. It is likely that this also will either increase the cost of high-quality coke production or will reduce the available domestic U.S. supply. Therefore, iron production in the United States utilizing the current, predominant Blast Furnace process will be more costly and would likely be curtailed due to a coke shortage. Therefore, there is a significant need to develop or extend the economic viability of Alternate Ironmaking Processes to at least partially replace current and declining blast furnace iron sources and to provide incentives for new capacity expansion. The primary conclusions of this comparative Study of Alternative Ironmaking Process scenarios are: (1) The processes with the best combined economics (CAPEX and OPEX impacts in the I.R.R. calculation) can be grouped into those Fine Ore based processes with no scrap

  9. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    Energy Technology Data Exchange (ETDEWEB)

    Greene, S.R.; Bevard, B.B. [and others

    1996-10-07

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES&H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives.

  10. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    International Nuclear Information System (INIS)

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives

  11. FMDP Reactor Alternative Summary Report: Volume 2 - CANDU heavy water reactor alternative

    International Nuclear Information System (INIS)

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 2 of a four volume report, summarizes the results of these analyses for the CANDU reactor based plutonium disposition alternative

  12. FMDP Reactor Alternative Summary Report: Volume 3 - partially complete LWR alternative

    International Nuclear Information System (INIS)

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 3 of a four volume report summarizes the results of these analyses for the partially complete LWR (PCLWR) reactor based plutonium disposition alternative

  13. Alternate approaches to nuclear safety

    International Nuclear Information System (INIS)

    For the US nuclear power industry to expand, a greatly increased portion of the public must come to share the industry's confidence in reactor safety. Major obstacles to establishing this confidence are frequent incidents with potential safety implications and a lack of incontrovertible proof that the risk of a major accident is very low. The most important step toward overcoming these obstacles would be for each utility to operate, maintain, and evaluate its reactors according to far higher standards. With improvements in reliability and safety margins, existing plants would be a stimulus for building new ones rather than an impediment. If changes to the operation of existing plants and improvements to the design of future ones were inadequate, the only hope for a revival of the nuclear industry would be an alternative reactor so obviously safe that risk would no longer be an issue. Three possible concepts are the modular high-temperature gas reactor, the process inherent ultimate safety reactor, and the liquid-metal fast reactor. All three have inherent safety features that should make a meltdown essentially impossible. They cannot know just how great the advantage of these alternate reactors would be, but the benefits of developing one or more of the concepts appear great

  14. Alternative approaches to plasma confinement

    Science.gov (United States)

    Roth, J. R.

    1978-01-01

    The paper discusses 20 plasma confinement schemes each representing an alternative to the tokamak fusion reactor. Attention is given to: (1) tokamak-like devices (TORMAC, Topolotron, and the Extrap concept), (2) stellarator-like devices (Torsatron and twisted-coil stellarators), (3) mirror machines (Astron and reversed-field devices, the 2XII B experiment, laser-heated solenoids, the LITE experiment, the Kaktus-Surmac concept), (4) bumpy tori (hot electron bumpy torus, toroidal minimum-B configurations), (5) electrostatically assisted confinement (electrostatically stuffed cusps and mirrors, electrostatically assisted toroidal confinement), (6) the Migma concept, and (7) wall-confined plasmas. The plasma parameters of the devices are presented and the advantages and disadvantages of each are listed.

  15. Introducing linear functions: an alternative statistical approach

    Science.gov (United States)

    Nolan, Caroline; Herbert, Sandra

    2015-12-01

    The introduction of linear functions is the turning point where many students decide if mathematics is useful or not. This means the role of parameters and variables in linear functions could be considered to be `threshold concepts'. There is recognition that linear functions can be taught in context through the exploration of linear modelling examples, but this has its limitations. Currently, statistical data is easily attainable, and graphics or computer algebra system (CAS) calculators are common in many classrooms. The use of this technology provides ease of access to different representations of linear functions as well as the ability to fit a least-squares line for real-life data. This means these calculators could support a possible alternative approach to the introduction of linear functions. This study compares the results of an end-of-topic test for two classes of Australian middle secondary students at a regional school to determine if such an alternative approach is feasible. In this study, test questions were grouped by concept and subjected to concept by concept analysis of the means of test results of the two classes. This analysis revealed that the students following the alternative approach demonstrated greater competence with non-standard questions.

  16. Alternative algebraic approaches in quantum chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Mezey, Paul G., E-mail: paul.mezey@gmail.com [Canada Research Chair in Scientific Modeling and Simulation, Department of Chemistry and Department of Physics and Physical Oceanography, Memorial University of Newfoundland, 283 Prince Philip Drive, St. John' s, NL A1B 3X7 (Canada)

    2015-01-22

    Various algebraic approaches of quantum chemistry all follow a common principle: the fundamental properties and interrelations providing the most essential features of a quantum chemical representation of a molecule or a chemical process, such as a reaction, can always be described by algebraic methods. Whereas such algebraic methods often provide precise, even numerical answers, nevertheless their main role is to give a framework that can be elaborated and converted into computational methods by involving alternative mathematical techniques, subject to the constraints and directions provided by algebra. In general, algebra describes sets of interrelations, often phrased in terms of algebraic operations, without much concern with the actual entities exhibiting these interrelations. However, in many instances, the very realizations of two, seemingly unrelated algebraic structures by actual quantum chemical entities or properties play additional roles, and unexpected connections between different algebraic structures are often giving new insight. Here we shall be concerned with two alternative algebraic structures: the fundamental group of reaction mechanisms, based on the energy-dependent topology of potential energy surfaces, and the interrelations among point symmetry groups for various distorted nuclear arrangements of molecules. These two, distinct algebraic structures provide interesting interrelations, which can be exploited in actual studies of molecular conformational and reaction processes. Two relevant theorems will be discussed.

  17. Alternative algebraic approaches in quantum chemistry

    International Nuclear Information System (INIS)

    Various algebraic approaches of quantum chemistry all follow a common principle: the fundamental properties and interrelations providing the most essential features of a quantum chemical representation of a molecule or a chemical process, such as a reaction, can always be described by algebraic methods. Whereas such algebraic methods often provide precise, even numerical answers, nevertheless their main role is to give a framework that can be elaborated and converted into computational methods by involving alternative mathematical techniques, subject to the constraints and directions provided by algebra. In general, algebra describes sets of interrelations, often phrased in terms of algebraic operations, without much concern with the actual entities exhibiting these interrelations. However, in many instances, the very realizations of two, seemingly unrelated algebraic structures by actual quantum chemical entities or properties play additional roles, and unexpected connections between different algebraic structures are often giving new insight. Here we shall be concerned with two alternative algebraic structures: the fundamental group of reaction mechanisms, based on the energy-dependent topology of potential energy surfaces, and the interrelations among point symmetry groups for various distorted nuclear arrangements of molecules. These two, distinct algebraic structures provide interesting interrelations, which can be exploited in actual studies of molecular conformational and reaction processes. Two relevant theorems will be discussed

  18. Alternative approaches to improve site investigations

    International Nuclear Information System (INIS)

    Common complaints about standard investigations at hazardous waste sites include high costs and long time frames. Investigations at military bases as part of the installation restoration program or base closures suffer additionally from nonuniformity of approach and results and redundancy of work effort conducted by multiple environmental contractors. The problems of high costs and long time frames can be minimized by the consistent use of alternative sampling methods (such as soil gas surveys) and the utilization of analytical screening procedures at both on-site and off-site laboratories. Acceptable data quality is maintained by several procedures. Incorporation of quality control measures (10 % frequency), such as matrix spikes and duplicates, into the alternative analytical techniques allows assessment of the data quality relative to predetermined data quality objectives (DQOs). Confirmation of the screening results (10% frequency) using standard US EPA methods, such as the contract laboratory program (CLP) statement of work (SOW), allows an additional evaluation of the data accuracy. Depending on the investigative objectives, knowledge based computer systems (expert systems,) could be used to improve uniformity of site evaluations. Several case histories will be presented demonstrating how soil gas surveys, screening analyses and standard analyses can be utilized to give increased site information in a reduced time frame and at a cost savings of 30 to 40%. One case history illustrates a screening technique developed by the author for polynuclear aromatics (semi-volatile organic compounds) that can be conducted at a cost savings of 90% relative to a standard US EPA method. A comparison of the phased investigative approach to one using an integrated field team is presented for fuel spill or UST areas

  19. Alternatives to traditional transportation fuels 1994. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    In this report, alternative and replacement fuels are defined in accordance with the EPACT. Section 301 of the EPACT defines alternative fuels as: methanol, denatured ethanol, and other alcohols; mixtures containing 85% or more (or such other percentage, but not less than 70%, as determined by the Secretary of Energy, by rule, to provide for requirements relating to cold start, safety, or vehicle functions) by volume of methanol, denatured ethanol, and other alcohols with gasoline or other fuels; natural gas; liquefied petroleum gas; hydrogen; coal-derived liquid fuels; fuels (other than alcohol) derived from biological materials; electricity (including electricity from solar energy); and any other fuel the Secretary determines, by rule, is substantially not petroleum and would yield substantial energy security benefits and substantial environmental benefits. The EPACT defines replacement fuels as the portion of any motor fuel that is methanol, ethanol, or other alcohols, natural gas, liquefied petroleum gas, hydrogen, coal-derived liquid fuels, fuels (other than alcohol) derived from biological materials, electricity (including electricity from solar energy), ethers, or any other fuel the Secretary of Energy determines, by rule, is substantially not petroleum and would yield substantial energy security benefits and substantial environmental benefits. This report covers only those alternative and replacement fuels cited in the EPACT that are currently commercially available or produced in significant quantities for vehicle demonstration purposes. Information about other fuels, such as hydrogen and biodiesel, will be included in later reports as those fuels become more widely used. Annual data are presented for 1992 to 1996. Data for 1996 are based on plans or projections for 1996.

  20. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 4. Alternatives for waste isolation and disposal

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume IV of the five-volume report contains information on alternatives for final storage and disposal of radioactive wastes. Section titles include: basic concepts for geologic isolation; geologic storage alternatives; geologic disposal alternatives; extraterrestrial disposal; and, transmutation. (JGB)

  1. Alternative Educational Approach to Introducing Cell Biology

    Directory of Open Access Journals (Sweden)

    Rosilane T. Silva

    2005-07-01

    Full Text Available First year medical students usually have a great  difficulty to visualize a three  dimensional  cell. They also present a series of misconceptions  related to cell biology that seems to begin in the high school. An alternative educational approach  is being tested  with high school students in order to minimize these misconceptions,  and also increase the pupils interest in the subject.  The approach  combines theoretical classes with experimental activities, the  use of models, games, discussions,  and oral presentations by the students at the end of the educational module.  In short,  the experimental activities  are low-cost, easy-to-follow experiments that basically show a few properties  of the living cells, such as membrane transport, enzyme action  as well as the  importance of the  membrane  integrity for life.  A card  game relates  the  functions  of the organnels  by matching  pairs  of cards.  This  game has one card without a matching  pair  that explains  apoptosis;  the  player  that ends up with  this  card  loses the game.   The pupils learn while they play the game.  A 3D model of the membrane  shows the major components  and allows the observation of membrane  assimetry.   After comparing  some panels of photomicrographs of cells and organnels, the students are presented  to a 3D model of a cell as the teacher  tries to relate the panels  with  a three  dimensional  visualization.  They  also have the  opportunity to present their  own models.  The opinion of high school teachers  about  the different activities  will be shown.  The aim of this educational module is to promote  learning while different abilities, according to Gardners  Multiple Intelligences  Theory,  such as the visual-spatial, bodily-kinesthetic, interpersonal, and naturalistic are being developed.  We believe that the diversity  of approaches  is one of the most important

  2. An alternative approach to school gymnastics

    OpenAIRE

    Keith Russell; Myrian Nunomura

    2008-01-01

    The author presents an approach that would integrate Laban’s movement analysis concepts to the content of gymnastics. For so, the author outlines an approach to gymnastics that represents a distillation of gymnastics rarefaction into a few themes or movement patterns from whence most gymnastics skills evolve. This approach provides teachers with easy-to-understand conceptual overview of the entire area of gymnastics, and de-emphasizes the restrictive nature of apparatus-specific skill learnin...

  3. Domain Approach: An Alternative Approach in Moral Education

    Science.gov (United States)

    Vengadasalam, Chander; Mamat, Wan Hasmah Wan; Mail, Fauziah; Sudramanian, Munimah

    2014-01-01

    This paper discusses the use of the domain approach in moral education in an upper secondary school in Malaysia. Moral Education needs a creative and an innovative approach. Therefore, a few forms of approaches are used in the teaching-learning of Moral Education. This research describes the use of domain approach which comprises the moral domain…

  4. Alternative approaches to evaluation in empirical microeconomics

    OpenAIRE

    Blundell, Richard; Costa Dias, Monica

    2002-01-01

    This paper reviews a range of the most popular policy evaluation methods in empirical microeconomics: social experiments, natural experiments, matching methods, instrumental variables, discontinuity design and control functions. It discusses the identification of both the traditionally used average parameters and more complex distributional parameters. In each case, the necessary assumptions and the data requirements are considered. The adequacy of each approach is discussed drawing on the em...

  5. Productivity Measurement: Alternative Approaches and Estimates

    OpenAIRE

    Peter Mawson; Kenneth I. Carlaw; Nathan McLellan

    2003-01-01

    This paper provides a review of conceptual and methodological issues in measuring productivity. Attention is given to the concept of productivity and the relationship between productivity and technological change. Different approaches to measuring productivity are surveyed and the results from a number of NZ productivity studies are summarised. The availability of appropriate input and output data is essential for the accurate measurement of productivity and therefore this paper also discusse...

  6. Alternative approach to fit irregular corneas

    OpenAIRE

    Espinosa Tomás, Julián; Pérez Rodríguez, Jorge; Mas Candela, David; Vázquez Ferri, Carmen; Illueca Contri, Carlos

    2010-01-01

    Comunicación presentada en 5th European Meeting on Visual and Physiological Optics (EMVPO), Stockholm, 22-24 August 2010. We propose a zonal Zernike fitting (combination of zonal and modal approaches) of corneal height data. It permits accurate analysis of the surface, diminishing the influence of smooth areas over irregular zones and vice versa. This fact will be of special interest in irregular corneas wavefront evaluation. This work has been supported by the Generalitat Valenciana pr...

  7. Heutagogy: An alternative practice based learning approach.

    Science.gov (United States)

    Bhoyrub, John; Hurley, John; Neilson, Gavin R; Ramsay, Mike; Smith, Margaret

    2010-11-01

    Education has explored and utilised multiple approaches in attempts to enhance the learning and teaching opportunities available to adult learners. Traditional pedagogy has been both directly and indirectly affected by andragogy and transformational learning, consequently widening our understandings and approaches toward view teaching and learning. Within the context of nurse education, a major challenge has been to effectively apply these educational approaches to the complex, unpredictable and challenging environment of practice based learning. While not offered as a panacea to such challenges, heutagogy is offered in this discussion paper as an emerging and potentially highly congruent educational framework to place around practice based learning. Being an emergent theory its known conceptual underpinnings and possible applications to nurse education need to be explored and theoretically applied. Through placing the adult learner at the foreground of grasping learning opportunities as they unpredictability emerge from a sometimes chaotic environment, heutagogy can be argued as offering the potential to minimise many of the well published difficulties of coordinating practice with faculty teaching and learning. PMID:20554249

  8. Matching Alternative Addresses: a Semantic Web Approach

    Science.gov (United States)

    Ariannamazi, S.; Karimipour, F.; Hakimpour, F.

    2015-12-01

    Rapid development of crowd-sourcing or volunteered geographic information (VGI) provides opportunities for authoritatives that deal with geospatial information. Heterogeneity of multiple data sources and inconsistency of data types is a key characteristics of VGI datasets. The expansion of cities resulted in the growing number of POIs in the OpenStreetMap, a well-known VGI source, which causes the datasets to outdate in short periods of time. These changes made to spatial and aspatial attributes of features such as names and addresses might cause confusion or ambiguity in the processes that require feature's literal information like addressing and geocoding. VGI sources neither will conform specific vocabularies nor will remain in a specific schema for a long period of time. As a result, the integration of VGI sources is crucial and inevitable in order to avoid duplication and the waste of resources. Information integration can be used to match features and qualify different annotation alternatives for disambiguation. This study enhances the search capabilities of geospatial tools with applications able to understand user terminology to pursuit an efficient way for finding desired results. Semantic web is a capable tool for developing technologies that deal with lexical and numerical calculations and estimations. There are a vast amount of literal-spatial data representing the capability of linguistic information in knowledge modeling, but these resources need to be harmonized based on Semantic Web standards. The process of making addresses homogenous generates a helpful tool based on spatial data integration and lexical annotation matching and disambiguating.

  9. Missile non-proliferation: an alternative approach

    International Nuclear Information System (INIS)

    In this report, the author first proposes an overview of the notion of missile prohibition. He notices that the association between weapons of mass destruction and missiles is a prelude to the legitimacy of missile control, notably within the framework of the Missile Technology Control Regime or MTCR. He also comments the notion of total ban. In a second part, the author analyses and discusses the limitations of the control of technology diffusion. He discusses the role of the MTCR, comments the evolution of this regime with the taking of China and Russia into consideration, the impacts of national implementations of export regimes on the MTCR, and economic aspects of control implementation. In the next part, the author addresses other kinds of limitations, i.e. those related with capacity evolutions of proliferating States. The last part addresses the evolution towards a new definition of approach to missile non-proliferation, notably in terms of perception of missile roles and of technology transfer controls

  10. Alternative Approaches to High Energy Density Fusion

    Science.gov (United States)

    Hammer, J.

    2016-03-01

    This paper explores selected approaches to High Energy Density (HED) fusion, beginning with discussion of ignition requirements at the National Ignition Facility (NIF). The needed improvements to achieve ignition are closely tied to the ability to concentrate energy in the implosion, manifested in the stagnation pressure, Pstag . The energy that must be assembled in the imploded state to ignite varies roughly as Pstag -2, so among other requirements, there is a premium on reaching higher Pstag to achieve ignition with the available laser energy. The U.S. inertial confinement fusion program (ICF) is pursuing higher Pstag on NIF through improvements to capsule stability and symmetry. One can argue that recent experiments place an approximate upper bound on the ultimate ignition energy requirement. Scaling the implosions consistently in spatial, temporal and energy scales shows that implosions of the demonstrated quality ignite robustly at 9-15 times the current energy of NIF. While lasers are unlikely to reach that bounding energy, it appears that pulsed-power sources could plausibly do so, giving a range of paths forward for ICF depending on success in improving energy concentration. In this paper, I show the scaling arguments then discuss topics from my own involvement in HED fusion. The recent Viewfactor experiments at NIF have shed light on both the observed capsule drive deficit and errors in the detailed modelling of hohlraums. The latter could be important factors in the inability to achieve the needed symmetry and energy concentration. The paper then recounts earlier work in Fast Ignition and the uses of pulsed- power for HED and fusion applications. It concludes with a description of a method for improving pulsed-power driven hohlraums that could potentially provide a factor of 10 in energy at NIF-like drive conditions and reach the energy bound for indirect drive ICF.

  11. Exactly Solvable Quantum Mechanical Potentials: An Alternative Approach.

    Science.gov (United States)

    Pronchik, Jeremy N.; Williams, Brian W.

    2003-01-01

    Describes an alternative approach to finding exactly solvable, one-dimensional quantum mechanical potentials. Differs from the usual approach in that instead of starting with a particular potential and seeking solutions to the related Schrodinger equations, it begins with known solutions to second-order ordinary differential equations and seeks to…

  12. Alternatives to peer review: novel approaches for research evaluation

    OpenAIRE

    Aliaksandr eBirukou; Joseph Rushton Wakeling; Claudio eBartolini; Fabio eCasati; Maurizio eMarchese; Katsiaryna eMirylenka; Nardine eOsman; Azzurra eRagone; Carles eSierra; Aalam eWassef

    2011-01-01

    In this paper we review several novel approaches for research evaluation. We start with a brief overview of the peer review, its controversies, and metrics for assessing efficiency and overall quality of the peer review. We then discuss five approaches, including reputation-based ones, that come out of the research carried out by the LiquidPub project and research groups collaborated with LiquidPub. Those approaches are alternative or complementary to traditional peer review. We discuss pros ...

  13. An Alternative Approach to Testing Dual Labour Market Theory

    OpenAIRE

    Launov, Andrey

    2004-01-01

    In this paper we suggest an alternative approach to testing for the dual structure of the labour market. The novelty of the suggested approach is that rather than considering wage determination we concentrate on the turnover. To perform the test we suggest using a latent class count data framework, which allows modelling the turnover in the unobserved primary and secondary markets in the appropriate way. To illustrate the suggested approach we apply our methodology to the German labour market...

  14. Cogeneration technology alternatives study. Volume 6: Computer data

    Science.gov (United States)

    1980-01-01

    The potential technical capabilities of energy conversion systems in the 1985 - 2000 time period were defined with emphasis on systems using coal, coal-derived fuels or alternate fuels. Industrial process data developed for the large energy consuming industries serve as a framework for the cogeneration applications. Ground rules for the study were established and other necessary equipment (balance-of-plant) was defined. This combination of technical information, energy conversion system data ground rules, industrial process information and balance-of-plant characteristics was analyzed to evaluate energy consumption, capital and operating costs and emissions. Data in the form of computer printouts developed for 3000 energy conversion system-industrial process combinations are presented.

  15. Alternative fuels for vehicles fleet demonstration program. Final report, volume 2: Appendices

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The Alternative Fuels for Vehicles Fleet Demonstration Program (AFV-FDP) was a multiyear effort to collect technical data for use in determining the costs and benefits of alternative-fuel vehicles (AFVs) in typical applications in New York State. This report, Volume 2, includes 13 appendices to Volume 1 that expand upon issues raised therein. Volume 1 provides: (1) Information about the purpose and scope of the AFV-FDP; (2) A summary of AFV-FDP findings organized on the basis of vehicle type and fuel type; (3) A short review of the status of AFV technology development, including examples of companies in the State that are active in developing AFVs and AFV components; and (4) A brief overview of the status of AFV deployment in the State. Volume 3 provides expanded reporting of AFV-FDP technical details, including the complete texts of the brochure Garage Guidelines for Alternative Fuels and the technical report Fleet Experience Survey Report, plus an extensive glossary of AFV terminology. The appendices cover a wide range of issues including: emissions regulations in New York State; production and health effects of ozone; vehicle emissions and control systems; emissions from heavy-duty engines; reformulated gasoline; greenhouse gases; production and characteristics of alternative fuels; the Energy Policy Act of 1992; the Clean Fuel Fleet Program; garage design guidelines for alternative fuels; surveys of fleet managers using alternative fuels; taxes on conventional and alternative fuels; and zero-emission vehicle technology.

  16. SLUDGE TREATMENT PROJECT ALTERNATIVES ANALYSIS SUMMARY REPORT (VOLUME 1)

    International Nuclear Information System (INIS)

    Highly radioactive sludge (containing up to 300,000 curies of actinides and fission products) resulting from the storage of degraded spent nuclear fuel is currently stored in temporary containers located in the 105-K West storage basin near the Columbia River. The background, history, and known characteristics of this sludge are discussed in Section 2 of this report. There are many compelling reasons to remove this sludge from the K-Basin. These reasons are discussed in detail in Section1, and they include the following: (1) Reduce the risk to the public (from a potential release of highly radioactive material as fine respirable particles by airborne or waterborn pathways); (2) Reduce the risk overall to the Hanford worker; and (3) Reduce the risk to the environment (the K-Basin is situated above a hazardous chemical contaminant plume and hinders remediation of the plume until the sludge is removed). The DOE-RL has stated that a key DOE objective is to remove the sludge from the K-West Basin and River Corridor as soon as possible, which will reduce risks to the environment, allow for remediation of contaminated areas underlying the basins, and support closure of the 100-KR-4 operable unit. The environmental and nuclear safety risks associated with this sludge have resulted in multiple legal and regulatory remedial action decisions, plans,and commitments that are summarized in Table ES-1 and discussed in more detail in Volume 2, Section 9

  17. SLUDGE TREATMENT PROJECT ALTERNATIVES ANALYSIS SUMMARY REPORT [VOLUME 1

    Energy Technology Data Exchange (ETDEWEB)

    FREDERICKSON JR; ROURK RJ; HONEYMAN JO; JOHNSON ME; RAYMOND RE

    2009-01-19

    Highly radioactive sludge (containing up to 300,000 curies of actinides and fission products) resulting from the storage of degraded spent nuclear fuel is currently stored in temporary containers located in the 105-K West storage basin near the Columbia River. The background, history, and known characteristics of this sludge are discussed in Section 2 of this report. There are many compelling reasons to remove this sludge from the K-Basin. These reasons are discussed in detail in Section1, and they include the following: (1) Reduce the risk to the public (from a potential release of highly radioactive material as fine respirable particles by airborne or waterborn pathways); (2) Reduce the risk overall to the Hanford worker; and (3) Reduce the risk to the environment (the K-Basin is situated above a hazardous chemical contaminant plume and hinders remediation of the plume until the sludge is removed). The DOE-RL has stated that a key DOE objective is to remove the sludge from the K-West Basin and River Corridor as soon as possible, which will reduce risks to the environment, allow for remediation of contaminated areas underlying the basins, and support closure of the 100-KR-4 operable unit. The environmental and nuclear safety risks associated with this sludge have resulted in multiple legal and regulatory remedial action decisions, plans,and commitments that are summarized in Table ES-1 and discussed in more detail in Volume 2, Section 9.

  18. A Comparison of Five Alternative Approaches to Information Systems Development

    Directory of Open Access Journals (Sweden)

    Rudy Hirschheim

    1997-11-01

    Full Text Available The field of information systems (IS has grown dramatically over the past three decades. Recent trends have transformed the IS landscape. These trends include: the evolution of implementation technology from centralized mainframe environments towards distributed client-server architectures, embracing the internet and intranets; changes in user interface technology from character-based to graphical user interfaces, multimedia, and the World Wide Web; changes in applications from transaction processing systems towards systems supporting collaborative work; and the use of information technology as an enabler of business process reengineering and redesign. These technology changes coupled with changes in organizations and their operating environment, such as the growth of the network and virtual organization, internationalization and globalization of many organizations, intensified global competition, changes in values such as customer orientation (service quality and Quality of Working Life, have imposed new demands on the development of information systems. These changes have led to an increasing discussion about information systems development (ISO, and in particular, the various methods, tools, methodologies, and approaches for ISD. We believe such discussion has opened the door for new, alternative IS development approaches and methodologies. Our paper takes up this theme by describing five alternative ISD approaches, namely the Interactionist approach, the Speech Act-based approach, Soft Systems Methodology, the Trade Unionist approach, and the Professional Work Practices approach. Despite the fact that most of these approaches have a history of over 15 years, their relevance to IS development is not well recognized in the mainstream of IS practice and research, nor is their institutional status comparable to traditional approaches such as structured analysis and design methods. Therefore we characterize the five approaches as 'alternative' in

  19. Alternatives to peer review: novel approaches for research evaluation

    Directory of Open Access Journals (Sweden)

    Aliaksandr eBirukou

    2011-12-01

    Full Text Available In this paper we review several novel approaches for research evaluation. We start with a brief overview of the peer review, its controversies, and metrics for assessing efficiency and overall quality of the peer review. We then discuss five approaches, including reputation-based ones, that come out of the research carried out by the LiquidPub project and research groups collaborated with LiquidPub. Those approaches are alternative or complementary to traditional peer review. We discuss pros and cons of the proposed approaches and conclude with a vision for the future of the research evaluation, arguing that no single system can suit all stakeholders in various communities.

  20. Alternative Contracting and Ownership Approaches for New Nuclear Power Plants

    International Nuclear Information System (INIS)

    This publication examines alternative contracting and ownership approaches for the development, construction, commissioning, operation, and decommissioning of new nuclear power plants. It identifies issues faced by IAEA Member States considering the applicability of such approaches to their respective national programmes. Two new approaches to nuclear project development are analysed. These are, firstly, the Build-Own-Operate (BOO)/Build-Own-Operate-Transfer (BOO(T)) and, secondly, Regional approaches. The information includes practical examples, current practices, and case studies, and reflects the presentations and discussions that took place in a series of IAEA meetings on this topic

  1. Calculation of plantar pressure time integral, an alternative approach.

    Science.gov (United States)

    Melai, Tom; IJzerman, T Herman; Schaper, Nicolaas C; de Lange, Ton L H; Willems, Paul J B; Meijer, Kenneth; Lieverse, Aloysius G; Savelberg, Hans H C M

    2011-07-01

    In plantar pressure measurement, both peak pressure and pressure time integral are used as variables to assess plantar loading. However, pressure time integral shows a high concordance with peak pressure. Many researchers and clinicians use Novel software (Novel GmbH Inc., Munich, Germany) that calculates this variable as the summation of the products of peak pressure and duration per time sample, which is not a genuine integral of pressure over time. Therefore, an alternative calculation method was introduced. The aim of this study was to explore the relevance of this alternative method, in different populations. Plantar pressure variables were measured in 76 people with diabetic polyneuropathy, 33 diabetic controls without polyneuropathy and 19 healthy subjects. Peak pressure and pressure time integral were obtained using Novel software. The quotient of the genuine force time integral over contact area was obtained as the alternative pressure time integral calculation. This new alternative method correlated less with peak pressure than the pressure time integral as calculated by Novel. The two methods differed significantly and these differences varied between the foot sole areas and between groups. The largest differences were found under the metatarsal heads in the group with diabetic polyneuropathy. From a theoretical perspective, the alternative approach provides a more valid calculation of the pressure time integral. In addition, this study showed that the alternative calculation is of added value, along peak pressure calculation, to interpret adapted plantar pressures patterns in particular in patients at risk for foot ulceration. PMID:21737281

  2. Alternative approaches to risk-based technical specifications

    International Nuclear Information System (INIS)

    Four alternative risk-based approaches to Technical Specifications are identified. These are: a Probabilistic Risk Assessment (PRA) oriented approach; a reliability goal-oriented approach; an approach based on configuration control; a data-oriented approach. Based on preliminary results, the PRA-oriented approach, which has been developed further than the other approaches, seems to offer a logical, quantitative basis for setting Allowed Outage Times (AOTs) and Surveillance Test Intervals (STIs) for some plant components and systems. The most attractive feature of this approach is that it directly links the AOTs and STIs with the risk associated with the operation of the plant. This would focus the plant operator's and the regulatory agency's attention on the most risk-significant components of the plant. A series of practical issues related to the level of detail and content of the plant PRAs, requirements for the review of these PRAs, and monitoring cf the plant's performance by the regulatory agency must be resolved before the approach could be implemented. Future efforts will examine the other three approaches and their practicality before firm conclusions are drawn regarding the viability of any of these approaches

  3. What approach to brain partial volume correction is best for PET/MRI?

    International Nuclear Information System (INIS)

    Many partial volume correction approaches make use of anatomical information, readily available in PET/MRI systems but it is not clear what approach is best. Seven novel approaches to partial volume correction were evaluated, including several post-reconstruction methods and several reconstruction methods that incorporate anatomical information. These were compared with an MRI-independent approach (reblurred van Cittert ) and uncorrected data. Monte Carlo PET data were generated for activity distributions representing both 18F FDG and amyloid tracer uptake. Post-reconstruction methods provided the best recovery with ideal segmentation but were particularly sensitive to mis-registration. Alternative approaches performed better in maintaining lesion contrast (unseen in MRI) with good noise control. These were also relatively insensitive to mis-registration errors. The choice of method will depend on the specific application and reliability of segmentation and registration algorithms

  4. What approach to brain partial volume correction is best for PET/MRI?

    Energy Technology Data Exchange (ETDEWEB)

    Hutton, B.F., E-mail: brian.hutton@uclh.nhs.uk [Institute of Nuclear Medicine, UCL, 235 Euston Road, London NW1 2BU (United Kingdom); Thomas, B.A., E-mail: benjamin.thomas2@uclh.nhs.uk [Institute of Nuclear Medicine, UCL, 235 Euston Road, London NW1 2BU (United Kingdom); Erlandsson, K., E-mail: kjell.erlandsson@uclh.nhs.uk [Institute of Nuclear Medicine, UCL, 235 Euston Road, London NW1 2BU (United Kingdom); Bousse, A., E-mail: alexandre.bousse@uclh.nhs.uk [Institute of Nuclear Medicine, UCL, 235 Euston Road, London NW1 2BU (United Kingdom); Reilhac-Laborde, A., E-mail: anthonin@ansto.gov.au [Australian Nuclear Science and Technology Organisation, Illawarra Road, Sydney (Australia); Kazantsev, D., E-mail: d.kazantsev@cs.ucl.ac.uk [Centre for Medical Image Computing, UCL, Malet Place Engineering, London WC1E 6BT (United Kingdom); Pedemonte, S., E-mail: s.pedemonte@cs.ucl.ac.uk [Centre for Medical Image Computing, UCL, Malet Place Engineering, London WC1E 6BT (United Kingdom); Vunckx, K., E-mail: kathleen.vunckx@UZleuven.be [Department of Nuclear Medicine, Katholieke Universiteit Leuven, B-3000 Leuven (Belgium); Arridge, S.R., E-mail: s.arridge@cs.ucl.ac.uk [Centre for Medical Image Computing, UCL, Malet Place Engineering, London WC1E 6BT (United Kingdom); Ourselin, S., E-mail: s.ourselin@cs.ucl.ac.uk [Centre for Medical Image Computing, UCL, Malet Place Engineering, London WC1E 6BT (United Kingdom)

    2013-02-21

    Many partial volume correction approaches make use of anatomical information, readily available in PET/MRI systems but it is not clear what approach is best. Seven novel approaches to partial volume correction were evaluated, including several post-reconstruction methods and several reconstruction methods that incorporate anatomical information. These were compared with an MRI-independent approach (reblurred van Cittert ) and uncorrected data. Monte Carlo PET data were generated for activity distributions representing both {sup 18}F FDG and amyloid tracer uptake. Post-reconstruction methods provided the best recovery with ideal segmentation but were particularly sensitive to mis-registration. Alternative approaches performed better in maintaining lesion contrast (unseen in MRI) with good noise control. These were also relatively insensitive to mis-registration errors. The choice of method will depend on the specific application and reliability of segmentation and registration algorithms.

  5. Alternative Monte Carlo Approach for General Global Illumination

    Institute of Scientific and Technical Information of China (English)

    徐庆; 李朋; 徐源; 孙济洲

    2004-01-01

    An alternative Monte Carlo strategy for the computation of global illumination problem was presented.The proposed approach provided a new and optimal way for solving Monte Carlo global illumination based on the zero variance importance sampling procedure. A new importance driven Monte Carlo global illumination algorithm in the framework of the new computing scheme was developed and implemented. Results, which were obtained by rendering test scenes, show that this new framework and the newly derived algorithm are effective and promising.

  6. Outdoor Education: An Alternative Approach in Teaching and Learning Science

    OpenAIRE

    Tuan Mastura Tuan Soh; Tamby Subahan Mohd. Meerah

    2013-01-01

    To understand fully and aware of children’s science learning, one should look not only at learning that takes place in the kindergarten and primary school but also in learning that takes place outside the classroom. This paper aims to discuss outdoor education: an alternative approach in teaching and learning science in the Malaysian context. In this 21st century, the exposure and experience in the field of science and technology are needed in nurturing interest among students who are involve...

  7. Determination of the Molar Volume of Hydrogen from the Metal-Acid Reaction: An Experimental Alternative.

    Science.gov (United States)

    de Berg, Kevin; Chapman, Ken

    1996-01-01

    Describes an alternative technique for determining the molar volume of hydrogen from the metal-acid reaction in which the metal sample is encased in a specially prepared cage and a pipette filler is used to fill an inverted burette with water. Eliminates some difficulties encountered with the conventional technique. (JRH)

  8. Alternative Neo-Rimannian Approaches to Carl Nielsen

    DEFF Research Database (Denmark)

    Nielsen, Svend Hvidtfelt

    theories of these above mentioned many writers, plus others, may be integrated into the two Danish theories. In discussing analytical theories the text is especially conversant with two recent books on Nielsen, Anne-Marie Reynolds’ The Voice of Carl Nielsen (2010) and Daniel Grimley’s Carl Nielsen and the......, whose theories in various degree is based on Riemannian analysis. The two Danes thus represent an alternative Neo-Riemannian approach to harmonic analysis. This approach has been developed from 1970 to 1989, the very same years in which Ernö Lendvai, David Lewin, Deborah Stein and Harald Krebs wrote...

  9. An Alternative Surgical Approach to Pseudoainhum: A Case Report.

    Science.gov (United States)

    Pirozzi, Kelly M; Piraino, Jason

    2016-01-01

    Pseudoainhum is a disorder of unknown etiology that is usually congenital and nonprogressive. One theory states it is caused by amnion band constriction in utero. These constriction bands lead, not only to a less cosmetically appealing foot, but also to long-term neurovascular compromise, resulting in amputation of the digit. The described surgical approaches have been limited within published data. The 2 procedures that have been described are either a Z-plasty or amputation, depending on the degree of the deformity. The present case report provides an alternative surgical approach to a pseudoainhum deformity of a third digit. PMID:26961414

  10. Approach for systematic evaluation of transuranic waste management alternatives

    International Nuclear Information System (INIS)

    This paper describes an approach for systematic evaluation of management alternatives that are being considered for the treatment, storage, and disposal of transuranic waste (TRUW) at U.S. Department of Energy sites. The approach, which is currently under development, would apply WASTE-MGMT, a database application model developed at Argonne National Laboratory, to estimate projected environmental releases and would evaluate impact measures such as health risk and costs associated with each of the waste management alternatives. The customized application would combine site-specific TRUW inventory and characterization data with treatment and transportation parameters to estimate the quantities and characteristics of the wastes to be treated, emissions of hazardous substances from the treatment facilities, and the quantities and characteristics of the wastes to be shipped between sites. These data would then be used to estimate for several TRUW management scenarios the costs and health risks of constructing and operating the required treatment facilities and of transporting TRUW for treatment and final disposal. Treatment, storage, and disposal of TRUW at DOE sites is composed of many variables and options at each stage. The approach described in this paper would provide for efficient consideration of all of these facets when evaluating potentially feasible TRUW management alternatives. By expanding existing databases, this model could eventually be adapted to accommodate the introduction of new treatment technologies, updated TRUW characterization data, and/or revised waste acceptance criteria

  11. Feasibility of Quantifying Arterial Cerebral Blood Volume Using Multiphase Alternate Ascending/Descending Directional Navigation (ALADDIN).

    Science.gov (United States)

    Kim, Ki Hwan; Choi, Seung Hong; Park, Sung-Hong

    2016-01-01

    Arterial cerebral blood volume (aCBV) is associated with many physiologic and pathologic conditions. Recently, multiphase balanced steady state free precession (bSSFP) readout was introduced to measure labeled blood signals in the arterial compartment, based on the fact that signal difference between labeled and unlabeled blood decreases with the number of RF pulses that is affected by blood velocity. In this study, we evaluated the feasibility of a new 2D inter-slice bSSFP-based arterial spin labeling (ASL) technique termed, alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in six healthy subjects. A new kinetic model considering bSSFP RF perturbations was proposed to describe the multiphase data and thus to quantify aCBV. Since the inter-slice time delay (TD) and gap affected the distribution of labeled blood spins in the arterial and tissue compartments, we performed the experiments with two TDs (0 and 500 ms) and two gaps (300% and 450% of slice thickness) to evaluate their roles in quantifying aCBV. Comparison studies using our technique and an existing method termed arterial volume using arterial spin tagging (AVAST) were also separately performed in five subjects. At 300% gap or 500-ms TD, significant tissue perfusion signals were demonstrated, while tissue perfusion signals were minimized and arterial signals were maximized at 450% gap and 0-ms TD. ALADDIN has an advantage of visualizing bi-directional flow effects (ascending/descending) in a single experiment. Labeling efficiency (α) of inter-slice blood flow effects could be measured in the superior sagittal sinus (SSS) (20.8±3.7%.) and was used for aCBV quantification. As a result of fitting to the proposed model, aCBV values in gray matter (1.4-2.3 mL/100 mL) were in good agreement with those from literature. Our technique showed high correlation with AVAST, especially when arterial signals were accentuated (i.e., when TD = 0 ms) (r = 0

  12. Feasibility of Quantifying Arterial Cerebral Blood Volume Using Multiphase Alternate Ascending/Descending Directional Navigation (ALADDIN)

    Science.gov (United States)

    Kim, Ki Hwan; Choi, Seung Hong; Park, Sung-Hong

    2016-01-01

    Arterial cerebral blood volume (aCBV) is associated with many physiologic and pathologic conditions. Recently, multiphase balanced steady state free precession (bSSFP) readout was introduced to measure labeled blood signals in the arterial compartment, based on the fact that signal difference between labeled and unlabeled blood decreases with the number of RF pulses that is affected by blood velocity. In this study, we evaluated the feasibility of a new 2D inter-slice bSSFP-based arterial spin labeling (ASL) technique termed, alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in six healthy subjects. A new kinetic model considering bSSFP RF perturbations was proposed to describe the multiphase data and thus to quantify aCBV. Since the inter-slice time delay (TD) and gap affected the distribution of labeled blood spins in the arterial and tissue compartments, we performed the experiments with two TDs (0 and 500 ms) and two gaps (300% and 450% of slice thickness) to evaluate their roles in quantifying aCBV. Comparison studies using our technique and an existing method termed arterial volume using arterial spin tagging (AVAST) were also separately performed in five subjects. At 300% gap or 500-ms TD, significant tissue perfusion signals were demonstrated, while tissue perfusion signals were minimized and arterial signals were maximized at 450% gap and 0-ms TD. ALADDIN has an advantage of visualizing bi-directional flow effects (ascending/descending) in a single experiment. Labeling efficiency (α) of inter-slice blood flow effects could be measured in the superior sagittal sinus (SSS) (20.8±3.7%.) and was used for aCBV quantification. As a result of fitting to the proposed model, aCBV values in gray matter (1.4–2.3 mL/100 mL) were in good agreement with those from literature. Our technique showed high correlation with AVAST, especially when arterial signals were accentuated (i.e., when TD = 0 ms) (r = 0

  13. Data summary of municipal solid waste management alternatives. Volume 2, Exhibits

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    The overall objective of the study in this report was to gather data on waste management technologies to allow comparison of various alternatives for managing municipal solid waste (MSW). The specific objectives of the study were to: 1. Compile detailed data for existing waste management technologies on costs, environmental releases, energy requirements and production, and coproducts such as recycled materials and compost. Identify missing information necessary to make energy, economic, and environmental comparisons of various MSW management technologies, and define needed research that could enhance the usefulness of the technology. 3. Develop a data base that can be used to identify the technology that best meets specific criteria defined by a user of the data base. Volume I contains the report text. Volume II contains supporting exhibits. Volumes III through X are appendices, each addressing a specific MSW management technology. Volumes XI and XII contain project bibliographies.

  14. Hanford spent nuclear fuel project recommended path forward, volume III: Alternatives and path forward evaluation supporting documentation

    International Nuclear Information System (INIS)

    Volume I of the Hanford Spent Nuclear Fuel Project - Recommended Path Forward constitutes an aggressive series of projects to construct and operate systems and facilities to safely retrieve, package, transport, process, and store K Basins fuel and sludge. Volume II provided a comparative evaluation of four Alternatives for the Path Forward and an evaluation for the Recommended Path Forward. Although Volume II contained extensive appendices, six supporting documents have been compiled in Volume III to provide additional background for Volume II

  15. The European Partnership for Alternative Approaches to Animal Testing (EPAA): Promoting Alternative Methods in Europe and Beyond

    OpenAIRE

    Cozigou, Gwenole; Crozier, Jonathan; HENDRIKSEN Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

    2015-01-01

    Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public–private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders....

  16. Alternative free volume models and positron cages for the characterisation of nanoporosity in materials

    International Nuclear Information System (INIS)

    Three semi-empirical positron stationary Quantum Models were developed for the study of nanoporosity in a wide range of solid porous materials. The cubic, conic and cylindrical well potentials were considered and their geometric parameters related to the Positron Annihilation LifeTime (PALT) measurements. If a conic or a cubic symmetry is assumed, a resonance lifetime phenomenon was found, which enables proposal of a technique to catch positrons in free volume sites. In the cylindrical case, an alternative method to determine free volume sizes in materials was developed. The free volume equations of these new models were then compared to the well-known and widely utilised Spherical Free Volume Model (SFVM) and remarkable differences were found. A strong variation of the free volume size-positron lifetime relation with the geometry involved was observed and a remarkable dependence of the electron layer thickness parameter ΔR with the hole-shape under study and with the nature of the material considered. The mathematical functions appearing in the conic and cylindrical cases are the superposition of Bessel functions of the first kind and trigonometric functions in the cubic case. Generalised free volume diagrams were constructed and a brief geometrical scheme of the diverse cases considered was obtained. (author)

  17. Management of radioactive waste gases from the nuclear fuel cycle. Volume I. Comparison of alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Evans, A.G.; Prout, W.E.; Buckner, J.T.; Buckner, M.R.

    1980-12-01

    Alternatives were compared for collection and fixation of radioactive waste gases released during normal operation of the nuclear fuel cycle, and for transportation and storage/disposal of the resulting waste forms. The study used a numerical rating scheme to evaluate and compare the alternatives for krypton-85, iodine-129, and carbon-14; whereas a subjective evaluation, based on published reports and engineering judgement, was made for transportation and storage/disposal options. Based on these evaluations, certain alternatives are recommended for an integrated scheme for waste management of each of the subject waste gases. Phase II of this project, which is concerned with the development of performance criteria for the waste forms associated with the subject gases, will be completed by the end of 1980. This work will be documented as Volume II of this report.

  18. The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond.

    Science.gov (United States)

    Cozigou, Gwenole; Crozier, Jonathan; Hendriksen, Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

    2015-03-01

    Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public-private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders. Through a brief description of EPAA's activities and organizational structure, we first articulate the value of this collaboration; we then focus on 2 key projects driven by EPAA. The first project aims to address research gaps on stem cells for safety testing, whereas the second project strives for an approach toward demonstration of consistency in vaccine batch release testing. We highlight the growing need for harmonization of international acceptance and implementation of alternative approaches and for increased international collaboration to foster progress on nonanimal alternatives. PMID:25836968

  19. An alternative approach for treatment of breast cancer.

    Science.gov (United States)

    Swartzendruber, D E; Retsky, M W; Wardwell, R H; Bame, P D

    1994-01-01

    Since adjuvant chemotherapy and hormonal therapy generally extend disease free survival in breast cancer rather than provide a cure, we have examined the current breast cancer paradigm. Heterogeneity is a fundamental characteristic of breast cancer tissue and a well recognized aspect of the disease. There are variations in natural history, histopathology, biochemistry and endocrinology, and molecular biology of cancer tissues and cells within the tissues. A variety of data indicate that growth kinetics are also variable, not only from tumor to tumor, but also during the natural history of an individual's tumor. To better understand kinetic heterogeneity, a stochastic numeric computer model of the natural history of breast cancer has been developed. To be consistent with inter- and intratumor kinetic heterogeneity and with late relapse, the model predicts that tumors grow in an irregular fashion with alternating periods of growth and periods of dormancy rather than the generally accepted modified exponential, or Gompertzian fasion. The prediction of irregular growth has been compared to data relevant to growth characteristics of human breast cancer. Much data support the concept of irregular kinetics and temporary dormancy rather than steady, Gompertzian growth of human breast cancer. Thus, in addition to drug resistance, kinetic heterogeneity may help explain the limited impact that traditional chemotherpeutic treatment has had on mortality from breast cancer. Although the mechanisms underlying irregular growth need to be better understood, non-Gompertzian growth kinetics indicates that there may be alternative approaches for breast cancer treatment. PMID:7865858

  20. An alternative approach to control measurements of crane rails.

    Science.gov (United States)

    Marjetič, Aleš; Kregar, Klemen; Ambrožič, Tomaž; Kogoj, Dušan

    2012-01-01

    Horizontal and vertical positions of points for the control assessment of crane rails are classically determined separately. The procedure is time consuming and causes non-homogenous accuracy of the horizontal and vertical position of control points. The proposed alternative approach is based on polar measurements using a high accuracy total station instrument and a special platform with two precise surveying prisms fixed on it. Measurements are carried out from a single station thus ensuring a common coordinate system and homogenous accuracy. The position of the characteristic point of a rail is derived from the measured positions of both prisms with known geometry of the platform. The influence of platform non-horizontality is defined, along with its elimination procedure. Accuracy assessment is ensured with redundant measurements. Result of the proposed procedure is a numerical and graphical presentation of characteristic points. The control parameters required in international Eurocode standards are easily determined from them. PMID:22778621

  1. Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystems Concepts. Volume 3; Program Cost Estimates

    Science.gov (United States)

    Levack, Daniel J. H.

    2000-01-01

    The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F- IA Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results , and the program cost estimates are described in more detail in Volume I - Executive Summary and in individual Final Task Reports.

  2. Alternative Fuel Cycle Evaluation Program. Volume IV. International Fuel Service Center evaluation. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Jacobson, L D [comp.

    1979-11-01

    This Alternative Fuel Cycle Evaluation Program (AFCEP) study presents the technical, economic and social aspects of the International Fuel Service Center (IFSC) as an institutional approach to nuclear fuel cycle development and is provided in support of the Nonproliferation Alternative Systems Assessment program (NASAP). Four types of IFSCs are described and evaluated in terms of three different twenty-year nuclear growth scenarios. Capital costs for each IFSC and comparable dispersed facility costs are discussed. Finally, the possible impact of each scenario and IFSC on the environmental and socio-economic structure is examined. 14 refs., 33 figs., 15 tabs.

  3. Alternating Direction Finite Volume Element Methods for Three-Dimensional Parabolic Equations

    Institute of Scientific and Technical Information of China (English)

    Tongke

    2010-01-01

    This paper presents alternating direction finite volume element methods for three-dimensional parabolic partial differential equations and gives four computational schemes, one is analogous to Douglas finite difference scheme with second-order splitting error, the other two schemes have third-order splitting error, and the last one is an extended LOD scheme. The L2 norm and H1 semi-norm error estimates are obtained for the first scheme and second one, respectively. Finally, two numerical examples are provided to illustrate the efficiency and accuracy of the methods.

  4. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

    International Nuclear Information System (INIS)

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

  5. A direct renormalization group approach for the excluded volume problem

    International Nuclear Information System (INIS)

    A direct renormalization group approach is proposed, to the excluded volume problem in a square lattice by considering percolating self-avoiding paths in a b x b cell, where b = 2,3. Two ways of counting these paths are presented. In the first one, we get the exponent ν = 0.715 for b = 2 and ν = 0.719 for b = 3, whereas in the second one ν = 0.771 for b = 2 and ν = 0.748 for b = 3. Comments are made on the extrapolation to b → infinite. (Author)

  6. Alternative Measuring Approaches in Gamma Scanning on Spent Nuclear Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Sihm Kvenangen, Karen

    2007-06-15

    In the future, the demand for energy is predicted to grow and more countries plan to utilize nuclear energy as their source of electric energy. This gives rise to many important issues connected to nuclear energy, such as finding methods that can verify that the spent nuclear fuel has been handled safely and used in ordinary power producing cycles as stated by the operators. Gamma ray spectroscopy is one method used for identification and verification of spent nuclear fuel. In the specific gamma ray spectroscopy method called gamma scanning the gamma radiation from the fission products Cs-137, Cs-134 and Eu-154 are measured in a spent fuel assembly. From the results, conclusions can be drawn about the fuels characteristics. This degree project examines the possibilities of using alternative measuring approaches when using the gamma scanning method. The focus is on examining how to increase the quality of the measured data. How to decrease the measuring time as compared with the present measuring strategy, has also been investigated. The main part of the study comprises computer simulations of gamma scanning measurements. The simulations have been validated with actual measurements on spent nuclear fuel at the central interim storage, Clab. The results show that concerning the quality of the measuring data the conventional strategy is preferable, but with other starting positions and with a more optimized equipment. When focusing on the time aspect, the helical measuring strategy can be an option, but this needs further investigation.

  7. Alternative Measuring Approaches in Gamma Scanning on Spent Nuclear Fuel

    International Nuclear Information System (INIS)

    In the future, the demand for energy is predicted to grow and more countries plan to utilize nuclear energy as their source of electric energy. This gives rise to many important issues connected to nuclear energy, such as finding methods that can verify that the spent nuclear fuel has been handled safely and used in ordinary power producing cycles as stated by the operators. Gamma ray spectroscopy is one method used for identification and verification of spent nuclear fuel. In the specific gamma ray spectroscopy method called gamma scanning the gamma radiation from the fission products Cs-137, Cs-134 and Eu-154 are measured in a spent fuel assembly. From the results, conclusions can be drawn about the fuels characteristics. This degree project examines the possibilities of using alternative measuring approaches when using the gamma scanning method. The focus is on examining how to increase the quality of the measured data. How to decrease the measuring time as compared with the present measuring strategy, has also been investigated. The main part of the study comprises computer simulations of gamma scanning measurements. The simulations have been validated with actual measurements on spent nuclear fuel at the central interim storage, Clab. The results show that concerning the quality of the measuring data the conventional strategy is preferable, but with other starting positions and with a more optimized equipment. When focusing on the time aspect, the helical measuring strategy can be an option, but this needs further investigation

  8. Outdoor Education: An Alternative Approach in Teaching and Learning Science

    Directory of Open Access Journals (Sweden)

    Tuan Mastura Tuan Soh

    2013-11-01

    Full Text Available To understand fully and aware of children’s science learning, one should look not only at learning that takes place in the kindergarten and primary school but also in learning that takes place outside the classroom. This paper aims to discuss outdoor education: an alternative approach in teaching and learning science in the Malaysian context. In this 21st century, the exposure and experience in the field of science and technology are needed in nurturing interest among students who are involved in this field. The advantages of experience-based learning which includes hands-on activities and on-site learning should be empowered. Thus, informal and non-formal science learning plays an important role in assisting all levels of society, regardless of age in exploring science and technology. Informal and non-formal learning of science is a complement to formal learning and occur in a variety of different places through various channels, such as the entertainment media, television and film; science centres and museums; zoos and aquariums, botanical gardens, and etc. This paper discusses the concept of science learning outside the classroom; the non-formal and informal science learning which covers the institutions/organizations involved in the non-formal science learning in Malaysia; and the potential of non-formal science centre setting in complement with the formal science education setting. It is hoped that this paper will provide an insight towards science learning out of school in Malaysian context.

  9. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume I. Program summary

    International Nuclear Information System (INIS)

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. The introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings, and recommendations. Each of Volumes II-VII reports on an individual assessment (Volumn II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

  10. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume I. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. The introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings, and recommendations. Each of Volumes II-VII reports on an individual assessment (Volumn II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP.

  11. Direct Volume Rendering of Curvilinear Volumes

    Science.gov (United States)

    Vaziri, Arsi; Wilhelms, J.; Challinger, J.; Alper, N.; Ramamoorthy, S.; Kutler, Paul (Technical Monitor)

    1998-01-01

    Direct volume rendering can visualize sampled 3D scalar data as a continuous medium, or extract features. However, it is generally slow. Furthermore, most algorithms for direct volume rendering have assumed rectilinear gridded data. This paper discusses methods for using direct volume rendering when the original volume is curvilinear, i.e. is divided into six-sided cells which are not necessarily equilateral hexahedra. One approach is to ray-cast such volumes directly. An alternative approach is to interpolate the sample volumes to a rectilinear grid, and use this regular volume for rendering. Advantages and disadvantages of the two approaches in terms of speed and image quality are explored.

  12. Preliminary evaluation of alternative waste form solidification processes. Volume II. Evaluation of the processes

    International Nuclear Information System (INIS)

    This Volume II presents engineering feasibility evaluations of the eleven processes for solidification of nuclear high-level liquid wastes (HHLW) described in Volume I of this report. Each evaluation was based in a systematic assessment of the process in respect to six principal evaluation criteria: complexity of process; state of development; safety; process requirements; development work required; and facility requirements. The principal criteria were further subdivided into a total of 22 subcriteria, each of which was assigned a weight. Each process was then assigned a figure of merit, on a scale of 1 to 10, for each of the subcriteria. A total rating was obtained for each process by summing the products of the subcriteria ratings and the subcriteria weights. The evaluations were based on the process descriptions presented in Volume I of this report, supplemented by information obtained from the literature, including publications by the originators of the various processes. Waste form properties were, in general, not evaluated. This document describes the approach which was taken, the developent and application of the rating criteria and subcriteria, and the evaluation results. A series of appendices set forth summary descriptions of the processes and the ratings, together with the complete numerical ratings assigned; two appendices present further technical details on the rating process

  13. Preliminary evaluation of alternative waste form solidification processes. Volume II. Evaluation of the processes

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    This Volume II presents engineering feasibility evaluations of the eleven processes for solidification of nuclear high-level liquid wastes (HHLW) described in Volume I of this report. Each evaluation was based in a systematic assessment of the process in respect to six principal evaluation criteria: complexity of process; state of development; safety; process requirements; development work required; and facility requirements. The principal criteria were further subdivided into a total of 22 subcriteria, each of which was assigned a weight. Each process was then assigned a figure of merit, on a scale of 1 to 10, for each of the subcriteria. A total rating was obtained for each process by summing the products of the subcriteria ratings and the subcriteria weights. The evaluations were based on the process descriptions presented in Volume I of this report, supplemented by information obtained from the literature, including publications by the originators of the various processes. Waste form properties were, in general, not evaluated. This document describes the approach which was taken, the developent and application of the rating criteria and subcriteria, and the evaluation results. A series of appendices set forth summary descriptions of the processes and the ratings, together with the complete numerical ratings assigned; two appendices present further technical details on the rating process.

  14. An Alternative Approach for the Determination of Soil Water Mobility

    Institute of Scientific and Technical Information of China (English)

    M.P.C.ENGLER; R.CICHOTA; Q.DE JONG VAN LIER; E.M.BLOEM; G.SPAROVEK; E. SCHNUG

    2008-01-01

    A new laboratory method was proposed to establish an easily performed standard for the determination of mobile soil water close to real conditions during the infiltration and redistribution of water in a soil.It consisted of applying a water volume with a tracer ion on top of an undisturbed ring sample on a pressure plate under a known suction or pressure head.Afterwards,soil water mobility was determined by analyzing the tracer-ion concentration in the soil sample.Soil water mobility showed to be a function of the applied water volume.No relation between soil water mobility and applied pressure head could be established with data from the present experiment.A simple one- or two-parameter equation can be fitted to the experimental data to parameterize soil water mobility as a function of applied solute volume.Sandy soils showed higher mobility than loamy soils at low values of applied solute volumes,and both sandy and loamy soils showed an almost complete mobility at high applied solute volumes.

  15. SU-E-J-35: Using CBCT as the Alternative Method of Assessing ITV Volume

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Y; Turian, J; Templeton, A; Redler, G; Chu, J [Rush University Medical Center, Chicago, IL (United States)

    2015-06-15

    Purpose To study the accuracy of Internal Target Volumes (ITVs) created on cone beam CT (CBCT) by comparing the visible target volume on CBCT to volumes (GTV, ITV, and PTV) outlined on free breathing (FB) CT and 4DCT. Methods A Quasar Cylindrical Motion Phantom with a 3cm diameter ball (14.14 cc) embedded within a cork insert was set up to simulate respiratory motion with a period of 4 seconds and amplitude of 2cm superioinferiorly and 1cm anterioposteriorly. FBCT and 4DCT images were acquired. A PTV-4D was created on the 4DCT by applying a uniform margin of 5mm to the ITV-CT. PTV-FB was created by applying a margin of the motion range plus 5mm, i.e. total of 1.5cm laterally and 2.5cm superioinferiorly to the GTV outlined on the FBCT. A dynamic conformal arc was planned to treat the PTV-FB with 1mm margin. A CBCT was acquired before the treatment, on which the target was delineated. During the treatment, the position of the target was monitored using the EPID in cine mode. Results ITV-CBCT and ITV-CT were measured to be 56.6 and 62.7cc, respectively, with a Dice Coefficient (DC) of 0.94 and disagreement in center of mass (COM) of 0.59 mm. On the other hand, GTV-FB was 11.47cc, 19% less than the known volume of the ball. PTV-FB and PTV-4D were 149 and 116 cc, with a DC of 0.71. Part of the ITV-CT was not enclosed by the PTV-FB despite the large margin. The cine EPID images have confirmed geometrical misses of the target. Similar under-coverage was observed in one clinical case and captured by the CBCT, where the implanted fiducials moved outside PTV-FB. Conclusion ITV-CBCT is in good agreement with ITV-CT. When 4DCT was not available, CBCT can be an effective alternative in determining and verifying the PTV margin.

  16. A Rule Based Approach to ISS Interior Volume Control and Layout

    Science.gov (United States)

    Peacock, Brian; Maida, Jim; Fitts, David; Dory, Jonathan

    2001-01-01

    Traditional human factors design involves the development of human factors requirements based on a desire to accommodate a certain percentage of the intended user population. As the product is developed human factors evaluation involves comparison between the resulting design and the specifications. Sometimes performance metrics are involved that allow leniency in the design requirements given that the human performance result is satisfactory. Clearly such approaches may work but they give rise to uncertainty and negotiation. An alternative approach is to adopt human factors design rules that articulate a range of each design continuum over which there are varying outcome expectations and interactions with other variables, including time. These rules are based on a consensus of human factors specialists, designers, managers and customers. The International Space Station faces exactly this challenge in interior volume control, which is based on anthropometric, performance and subjective preference criteria. This paper describes the traditional approach and then proposes a rule-based alternative. The proposed rules involve spatial, temporal and importance dimensions. If successful this rule-based concept could be applied to many traditional human factors design variables and could lead to a more effective and efficient contribution of human factors input to the design process.

  17. Alternative Education for the 21st Century: Philosophies, Approaches, Visions

    Science.gov (United States)

    Woods, Philip A., Ed.; Woods, Glenys J., Ed.

    2008-01-01

    This is a unique collection of leading examples of education grounded in alternative philosophies and cultures--from initiatives to create more democratic schools, through Quaker, Buddhist, Islamic, Montessori and Steiner/Waldorf schools, to Maori and First Nations education in Canada and Palestinian Jewish schools in Israel. Aimed at educational…

  18. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 2. Alternatives for waste treatment

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume II of the five-volume report is devoted to the description of alternatives for waste treatment. The discussion is presented under the following section titles: fuel reprocessing modifications; high-level liquid waste solidification; treatment and immobilization of chop-leach fuel bundle residues; treatment of noncombustible solid wastes; treatment of combustible wastes; treatment of non-high-level liquid wastes; recovery of transuranics from non-high-level wastes; immobilization of miscellaneous non-high-level wastes; volatile radioisotope recovery and off-gas treatment; immobilization of volatile radioisotopes; retired facilities (decontamination and decommissioning); and, modification and use of selected fuel reprocessing wastes. (JGB)

  19. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 2. Alternatives for waste treatment

    International Nuclear Information System (INIS)

    Volume II of the five-volume report is devoted to the description of alternatives for waste treatment. The discussion is presented under the following section titles: fuel reprocessing modifications; high-level liquid waste solidification; treatment and immobilization of chop-leach fuel bundle residues; treatment of noncombustible solid wastes; treatment of combustible wastes; treatment of non-high-level liquid wastes; recovery of transuranics from non-high-level wastes; immobilization of miscellaneous non-high-level wastes; volatile radioisotope recovery and off-gas treatment; immobilization of volatile radioisotopes; retired facilities (decontamination and decommissioning); and, modification and use of selected fuel reprocessing wastes

  20. Alternative approaches to research in physical therapy: positivism and phenomenology.

    Science.gov (United States)

    Shepard, K F; Jensen, G M; Schmoll, B J; Hack, L M; Gwyer, J

    1993-02-01

    This article presents philosophical approaches to research in physical therapy. A comparison is made to demonstrate how the research purpose, research design, research methods, and research data differ when one approaches research from the philosophical perspective of positivism (predominantly quantitative) as compared with the philosophical perspective of phenomenology (predominantly qualitative). Differences between the two approaches are highlighted by examples from research articles published in Physical Therapy. The authors urge physical therapy researchers to become familiar with the tenets, rigor, and knowledge gained from the use of both approaches in order to increase their options in conducting research relevant to the practice of physical therapy. PMID:8421722

  1. Complementary and Alternative Approaches to Pain Relief during Labor

    Directory of Open Access Journals (Sweden)

    Michel Tournaire

    2007-01-01

    Full Text Available This review evaluated the effect of complementary and alternative medicine on pain during labor with conventional scientific methods using electronic data bases through 2006 were used. Only randomized controlled trials with outcome measures for labor pain were kept for the conclusions. Many studies did not meet the scientific inclusion criteria. According to the randomized control trials, we conclude that for the decrease of labor pain and/or reduction of the need for conventional analgesic methods: (i There is an efficacy found for acupressure and sterile water blocks. (ii Most results favored some efficacy for acupuncture and hydrotherapy. (iii Studies for other complementary or alternative therapies for labor pain control have not shown their effectiveness.

  2. The rationale for South-South trade; An Alternative Approach

    OpenAIRE

    Shafaeddin, Mehdi

    2010-01-01

    Arguing that the theoretical literature on South-South trade is not satisfactory, the author provides an alternative framework and rationale for the South-South trade as a vehicle for industrialization and development of developing countries. He also applies this framework to developing countries in the Asia-Pacific region. In particular, showing that the low-income countries of the region are not benefiting much from the dynamism of the China market for their industrialization, he proposes, ...

  3. Towards a Strategic Approaches in Alternative Tests for Pesticide Safety

    OpenAIRE

    Jang, Yoonjeong; Kim, Ji-Eun; Jeong, Sang-Hee; Cho, Myung-Haing

    2014-01-01

    Pesticides have provided significant benefits including plant disease control and increased crop yields since people developed and utilized them. However, pesticide use is associated with many adverse effects, which necessitate precise toxicological tests and risk assessment. Most of these methods are based on animal studies, but considerations of animal welfare and ethics require the development of alternative methods for the evaluation of pesticide toxicity. Although the usage of laboratory...

  4. Alternative Approach to Teaching Veterinary Anatomy: A Progress Report

    Science.gov (United States)

    Hullinger, Ronald; Render, Gary F.

    1975-01-01

    Students in microscopic anatomy at Purdue University School of Veterinary Medicine selected a self-directed or teacher-directed approach to the course. Adoption of the experimental approach described here increased faculty time for evaluating student progress but was supportive of student development particularly in cognitive skills and affective…

  5. Teaching about radioactivity and ionising radiation: an alternative approach

    International Nuclear Information System (INIS)

    This article reviews children's ideas about radiation and radioactivity and identifies several common areas of misunderstanding. A new approach to teaching the topic at school level, which seeks specifically to address these known difficulties, is then proposed and outlined. (author)

  6. INTEGRATED DESIGN OF ALTERNATIVE ENERGY OPTIONS - A MULTICRITERIA APPROACH

    OpenAIRE

    Polatidis, Heracles; Haralambopoulos, Dias

    2005-01-01

    Energy planning has come a long way during the 20th century from an intuitive approach to a full-scale discipline, incorporating technological and economic dimensions. The latter include both the micro- and the macro- level, whereas the technological framework covers energy, technology, thermodynamics and thermo-economic approaches. It is only during the last two decades that the environmental aspects of energy conversion has started to assume the gravity that it should have been assigned per...

  7. Life After Kyoto: Alternative Approaches to Global Warming

    OpenAIRE

    William Nordhaus

    2005-01-01

    This study reviews different approaches to the political and economic control of global public goods like global warming. It compares quantity-oriented control mechanisms like the Kyoto Protocol with price-type control mechanisms such as internationally harmonized carbon taxes. The pros and cons of the two approaches are compared, focusing on such issues as performance under conditions of uncertainty, volatility of the induced carbon prices, the excess burden of taxation and regulation, poten...

  8. TRADITIONAL AND ALTERNATIVE APPROACHES TO QUANTIFY THE RISK FOR BUSINESS

    OpenAIRE

    ANCA JARMILA GUŢĂ; GABRIELA CORINA SLUSARIUC

    2010-01-01

    The paper proposes to present the approaches modalities of the risk to which an investor is subjected in various situations during the development of its business. The risk description is based on the idea of quantifying the probability of occurrence and severity of the event the reason for which in the approach of business risk is necessary to treat the probability distributions in the occurence of risk and their construction methods. Paper also highlights how the work of measuring risk can ...

  9. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Volume II assesses proliferation resistance. Chapters are devoted to: assessment of civilian nuclear systems (once-through fuel-cycle systems, closed fuel cycle systems, research reactors and critical facilities); assessment of associated sensitive materials and facilities (enrichment, problems with storage of spent fuel and plutonium content, and reprocessing and refabrication facilities); and safeguards for alternative fuel cycles.

  10. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    International Nuclear Information System (INIS)

    Volume II assesses proliferation resistance. Chapters are devoted to: assessment of civilian nuclear systems (once-through fuel-cycle systems, closed fuel cycle systems, research reactors and critical facilities); assessment of associated sensitive materials and facilities (enrichment, problems with storage of spent fuel and plutonium content, and reprocessing and refabrication facilities); and safeguards for alternative fuel cycles

  11. Extraoral periapical radiography: an alternative approach to intraoral periapical radiography.

    Science.gov (United States)

    Kumar, Rahul; Khambete, Neha; Priya, Ekta

    2011-12-01

    It is difficult to take intraoral radiographs in some patients who are intolerable to place the film in their mouth. For these patients, Newman and Friedman recommended a new technique of extraoral film placement. Here we report various cases that diagnostic imaging was performed in patients using the extraoral periapical technique. This technique was used to obtain the radiographs for the patients with severe gag reflex, pediatric dental patients, and patients with restricted mouth opening. This technique can be recommended as an alternative to conventional intraoral periapical technique in cases where intraoral film placement is difficult to achieve. PMID:22232725

  12. Extraoral periapical radiography: an alternative approach to intraoral periapical radiography

    International Nuclear Information System (INIS)

    It is difficult to take intraoral radiographs in some patients who are intolerable to place the film in their mouth. For these patients, Newman and Friedman recommended a new technique of extraoral film placement. Here we report various cases that diagnostic imaging was performed in patients using the extraoral periapical technique. This technique was used to obtain the radiographs for the patients with severe gag reflex, pediatric dental patients, and patients with restricted mouth opening. This technique can be recommended as an alternative to conventional intraoral periapical technique in cases where intraoral film placement is difficult to achieve.

  13. Extraoral periapical radiography: an alternative approach to intraoral periapical radiography

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Rahul [Vasantdada Patil Dental College and Hospital, Sangli (India); Khambete, Neha [CSMSS Dental College and Hospital, Aurangabad (India); Priya, Ekta [Saveetha Dental College and Hospital, Chennai (India)

    2011-12-15

    It is difficult to take intraoral radiographs in some patients who are intolerable to place the film in their mouth. For these patients, Newman and Friedman recommended a new technique of extraoral film placement. Here we report various cases that diagnostic imaging was performed in patients using the extraoral periapical technique. This technique was used to obtain the radiographs for the patients with severe gag reflex, pediatric dental patients, and patients with restricted mouth opening. This technique can be recommended as an alternative to conventional intraoral periapical technique in cases where intraoral film placement is difficult to achieve.

  14. Testing and assessment strategies, including alternative and new approaches

    DEFF Research Database (Denmark)

    Meyer, Otto A.

    2003-01-01

    ethical concern. However, irrespective of animal welfare it is an important aspect of the discipline of toxicology that the primary object is human health. The ideal testing and assessment strategy is simple to use all the available test methods and preferably more in laboratory animal species from which...... there are more than 100000 chemicals which are potential for human exposure, so the development of alternative testing and assessment strategies has taken place in the recent years. The toxicological evaluation should enable the society to cope with the simultaneous requirement of many chemicals for...

  15. Alternating chemo-radiotherapy in bladder cancer: A conservative approach

    Energy Technology Data Exchange (ETDEWEB)

    Orsatti, M.; Franzone, P.; Giudici, S. [Istituto Nazionale per la Ricerca sul Cancro, Genova (Switzerland)] [and others

    1995-08-30

    The aim of this Phase II study was to determine a bladder-sparing treatment in patients with invasive bladder cancer, allowing a better quality of life. Objectives were to test toxicity and disease-free and overall survival of patients given an alternated chemo-radiotherapy definitive treatment. Seventy-six patients with bladder cancer Stage T1G3 through T4 N0 M0 were entered in the same chemotherapy regimen (Cisplatin 20 mg/mq and 5-Fluorouracil 200 mg/mq daily for 5 days) alternated with different radiotherapy scheduling, the first 18 patients received two cycles of 20 Gy/10 fractions/12 days each; the second group of 58 patients received two cycles of 25 Gy/10 fractions/12 days each (the last 21 patients received Methotrexate 40 mg/mq instead of 5-Fluorouracil). A clinical complete response was observed in 57 patients (81%), partial response in 7 patients (10%), and a nonresponse in 6 patients (9%). At a median follow-up of 45 months, 33 patients (47%) were alive and free of tumor. The 6-year overall survival and progression-free survival was 42% and 40%, respectively. Systemic side effects were mild, while a moderate or severe local toxicity was observed in 14 patients and 13 patients (about 20%), respectively. Our conservative combination treatment allowed bladder-sparing in a high rate of patients and resulted in a survival comparable to that reported after radical cystectomy. 34 refs., 4 figs., 5 tabs.

  16. A bibliometric approach to the Alternative Medicine in chronic pain

    Directory of Open Access Journals (Sweden)

    Ennio Cocco

    2009-03-01

    Full Text Available The aim of this study is to investigate the interest of science for the Complementary and Alternative Medicine (CAM in the chronic pain treatment using the number of articles registered by PubMed as an indicator. On Medline system with the key words: CAM and Pain 11.671 papers are available; 2.167 with the key words: CAM and chronic pain; 192 papers deal with the topic chronic pain and dementia. The interest of science for CAM in chronic pain is increasing, but few studies deal with the epidemiological and psychosocial side of this phenomenon. Analogously, more and more studies deal with CAM utilization in dementia. More studies deal with the specific problem of chronic pain in dementia, but few include CAM referral for this topic. A different vision should be dedicated to CAM in chronic pain especially for a better understanding of patients’ (and their families’ needs.

  17. The alternative Pharaoh approach: stingless bees mummify beetle parasites alive

    Science.gov (United States)

    Greco, Mark K.; Hoffmann, Dorothee; Dollin, Anne; Duncan, Michael; Spooner-Hart, Robert; Neumann, Peter

    2010-03-01

    Workers from social insect colonies use different defence strategies to combat invaders. Nevertheless, some parasitic species are able to bypass colony defences. In particular, some beetle nest invaders cannot be killed or removed by workers of social bees, thus creating the need for alternative social defence strategies to ensure colony survival. Here we show, using diagnostic radioentomology, that stingless bee workers ( Trigona carbonaria) immediately mummify invading adult small hive beetles ( Aethina tumida) alive by coating them with a mixture of resin, wax and mud, thereby preventing severe damage to the colony. In sharp contrast to the responses of honeybee and bumblebee colonies, the rapid live mummification strategy of T. carbonaria effectively prevents beetle advancements and removes their ability to reproduce. The convergent evolution of mummification in stingless bees and encapsulation in honeybees is another striking example of co-evolution between insect societies and their parasites.

  18. Testing and assessment strategies, including alternative and new approaches.

    Science.gov (United States)

    Meyer, Otto

    2003-04-11

    The object of toxicological testing is to predict possible adverse effect in humans when exposed to chemicals whether used as industrial chemicals, pharmaceuticals or pesticides. Animal models are predominantly used in identifying potential hazards of chemicals. The use of laboratory animals raises ethical concern. However, irrespective of animal welfare it is an important aspect of the discipline of toxicology that the primary object is human health. The ideal testing and assessment strategy is simple to use all the available test methods and preferably more in laboratory animal species from which we get as many data as possible in order to obtain the most extensive database for the toxicological evaluation of a chemical. Consequently, the society has decided that certain group of chemicals should be tested accordingly. However, realising that, this idea is not obtainable in practice because there are more than 100000 chemicals which are potential for human exposure, so the development of alternative testing and assessment strategies has taken place in the recent years. The toxicological evaluation should enable the society to cope with the simultaneous requirement of many chemicals for different uses and of the absence of health problems involved with their use. Thus, the regulatory toxicology is a cocktail of science and pragmatism added a crucial concern for animal welfare. Test methods are most often used in a testing sequence as bricks in a testing strategy. The main key driving forces for introducing assessment and testing strategies e.g. using a limited number of tests and/or alternative test methods are: (a) animal welfare considerations; (b) new scientific knowledge i.e. introducing tests for new endpoints and tests for better understanding of mode of action; and (c) lack of testing capacity/reduction of required resources economically as well as time wise. PMID:12676447

  19. Sequential Bayesian technique: An alternative approach for software reliability estimation

    Indian Academy of Sciences (India)

    S Chatterjee; S S Alam; R B Misra

    2009-04-01

    This paper proposes a sequential Bayesian approach similar to Kalman filter for estimating reliability growth or decay of software. The main advantage of proposed method is that it shows the variation of the parameter over a time, as new failure data become available. The usefulness of the method is demonstrated with some real life data

  20. An alternative treatment approach in tetanus: Botulinum toxin.

    Science.gov (United States)

    Demir, Nazlim Aktug; Sumer, Sua; Ural, Onur; Ozturk, Serefnur; Celik, Jale Bengi

    2015-01-01

    Tetanus is a preventable infectious disease caused by tetanus toxin (tetanospasmin) produced by Clostridium tetani. Tetanus is still an important health problem in low- and middle-income countries (LMICs). Botulinum toxin administration is a treatment approach that has been used in recent years to reduce rigidity and spasms in tetanus patients. This case report focuses on its efficacy. PMID:25234426

  1. Supplemental/Replacement: An Alternative Approach to Excess Costs.

    Science.gov (United States)

    Hartman, William T.

    1990-01-01

    This article proposes a new operational definition of excess cost in determining state and federal funding for special education. The new approach is based on programs and services rather than accounting calculations of the difference between special education cost per student and regular education cost per student. (Author/DB)

  2. Taxation of Fringe Benefits: Alternative Approaches to Current Problems.

    Science.gov (United States)

    Cohen, Anita E.

    1979-01-01

    The current IRS tax treatment of fringe benefits is seen as inadequate, and the judicial precept confusing, because groups of employee benefits are inappropriately excluded from taxation as perquisites. A tax equalization approach is proposed. Available from Suffolk University Law Review Office, 41 Temple St., Boston, MA 02114. (MSE)

  3. Freinet Pedagogy: An Alternative Approach to Traditional Schools.

    Science.gov (United States)

    Lee, William B.

    1993-01-01

    Describes the philosophy and operation of schools based on the ideas of Celestin Freinet, founder of the Ecole Moderne movement. Discusses the child-centered approach, cooperative-learning techniques, and participatory decision making that are characteristic of these schools. Points out that the curriculum frequently emphasizes contemporary social…

  4. Alternative Approaches to Postgraduate Supervision: A Planning Tool to Facilitate Supervisory Processes

    Science.gov (United States)

    Bitzer, E. M.; Albertyn, R. M.

    2011-01-01

    Increased demands on academics due to the changing work and higher educational environments challenge traditional approaches to postgraduate supervision. Supervisors often tend to follow the apprenticeship approach uncritically. Supervisors therefore need to be aware of alternative approaches to supervision and of the need for structured planning…

  5. Corporate finance in an interest free economy: An alternate approach to practiced Islamic Corporate Finance

    OpenAIRE

    Shaikh, Salman

    2009-01-01

    This paper suggests an alternate approach to corporate finance in an interest free economy by looking beyond practiced Islamic finance and suggesting alternatives for corporate finance in sourcing funds i.e. i) Ijara with embedded options, ii) limited liability partnership, iii) equity modes like Musharakah and Mudarabah iv) income bonds and v) convertible income bonds. It also suggests alternatives for corporate finance in using funds i.e. i) Islamic income funds, ii) Islamic REITs, iii) Tre...

  6. The machine paradigm and alternative approaches in cognitive science.

    Science.gov (United States)

    Barutta, Joaquín; Aravena, Pía; Ibáñez, Agustín

    2010-06-01

    In a recent paper called To think human out of the machine paradigm, it is stated that psychological science operates within a machine paradigm that is committed to mechanical causality. In addition, it is emphasizes the epistemological and methodological limitations of explanations based in deterministic mechanics and instead argues for the need of an 'organic paradigm' that takes into consideration psychological processes such as subjectivity, inter-subjectivity, and agency. Although there is no doubt that much psychological science has operated under a machine paradigm, we argue that recent psychological research is pursued using a wide variety of approaches and with an absence of a partially integrated meta-theoretical corpus. The present situation looks more like a Tower of Babel of epistemological approaches and empirical programs. The reconsideration of the organic paradigm and an explicitly addressed epistemological framework could constitute a step forward and lead to an explanatory pluralism built on greater dialogue within the psychological sciences. PMID:20306344

  7. Alternative Approaches for Rating INDCs: a Comparative Analysis

    OpenAIRE

    Davide, Marinella; Vesco, Paola

    2016-01-01

    The “Intended nationally determined contributions” (INDCs) communicated by both developing and developed countries represent a crucial element of the Paris agreement. This paper aims at analysing the INDCs submitted by Parties, through the different tools and approaches proposed by the research community. In particular, our analysis looks at the different ways to assess the effectiveness of the proposed emission reduction pledges, both in terms of aggregate and national efforts. However, we a...

  8. Mechanistic approaches and the development of alternative toxicity test methods.

    OpenAIRE

    Balls, M

    1998-01-01

    A mechanism can be defined as an explanation of an observed phenomenon that explains the processes underlying the phenomenon in terms of events at lower levels of organization. A prerequisite for new, more mechanistic, approaches, which would use in vitro systems rather than conventional animal analogy models, is a strengthening of the underlying scientific basis of toxicity testing. This will require greater recognition of the differences between fidelity and discrimination models and betwee...

  9. Space modification: an alternative approach to chemistry problems involving geometry

    Energy Technology Data Exchange (ETDEWEB)

    Silver, G.L.

    1981-01-01

    The sequential simplex optimization algorithm has been translated into non-Euclidean space. A study of the algorithm in this space suggests that the path of convergence of the simplex depends on the properties of the space so that different convergence paths can be obtained even with the same starting points. The path of convergence approaches the path observed in Euclidean space as the metric constant of the hyperbolic space increases.

  10. An alternative subspace approach to EEG dipole source localization

    Energy Technology Data Exchange (ETDEWEB)

    Xu Xiaoliang [KC Science and Technologies Inc., Naperville, IL 60565 (United States); Xu, Bobby [Illinois Mathematics and Science Academy, Aurora, IL 60506 (United States); He Bin [Department of Bioengineering, University of Illinois, Chicago, IL 60607 (United States)

    2004-01-21

    In the present study, we investigate a new approach to electroencephalography (EEG) three-dimensional (3D) dipole source localization by using a non-recursive subspace algorithm called FINES. In estimating source dipole locations, the present approach employs projections onto a subspace spanned by a small set of particular vectors (FINES vector set) in the estimated noise-only subspace instead of the entire estimated noise-only subspace in the case of classic MUSIC. The subspace spanned by this vector set is, in the sense of principal angle, closest to the subspace spanned by the array manifold associated with a particular brain region. By incorporating knowledge of the array manifold in identifying FINES vector sets in the estimated noise-only subspace for different brain regions, the present approach is able to estimate sources with enhanced accuracy and spatial resolution, thus enhancing the capability of resolving closely spaced sources and reducing estimation errors. The present computer simulations show, in EEG 3D dipole source localization, that compared to classic MUSIC, FINES has (1) better resolvability of two closely spaced dipolar sources and (2) better estimation accuracy of source locations. In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist.

  11. An alternative subspace approach to EEG dipole source localization

    Science.gov (United States)

    Xu, Xiao-Liang; Xu, Bobby; He, Bin

    2004-01-01

    In the present study, we investigate a new approach to electroencephalography (EEG) three-dimensional (3D) dipole source localization by using a non-recursive subspace algorithm called FINES. In estimating source dipole locations, the present approach employs projections onto a subspace spanned by a small set of particular vectors (FINES vector set) in the estimated noise-only subspace instead of the entire estimated noise-only subspace in the case of classic MUSIC. The subspace spanned by this vector set is, in the sense of principal angle, closest to the subspace spanned by the array manifold associated with a particular brain region. By incorporating knowledge of the array manifold in identifying FINES vector sets in the estimated noise-only subspace for different brain regions, the present approach is able to estimate sources with enhanced accuracy and spatial resolution, thus enhancing the capability of resolving closely spaced sources and reducing estimation errors. The present computer simulations show, in EEG 3D dipole source localization, that compared to classic MUSIC, FINES has (1) better resolvability of two closely spaced dipolar sources and (2) better estimation accuracy of source locations. In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist.

  12. An alternative subspace approach to EEG dipole source localization

    International Nuclear Information System (INIS)

    In the present study, we investigate a new approach to electroencephalography (EEG) three-dimensional (3D) dipole source localization by using a non-recursive subspace algorithm called FINES. In estimating source dipole locations, the present approach employs projections onto a subspace spanned by a small set of particular vectors (FINES vector set) in the estimated noise-only subspace instead of the entire estimated noise-only subspace in the case of classic MUSIC. The subspace spanned by this vector set is, in the sense of principal angle, closest to the subspace spanned by the array manifold associated with a particular brain region. By incorporating knowledge of the array manifold in identifying FINES vector sets in the estimated noise-only subspace for different brain regions, the present approach is able to estimate sources with enhanced accuracy and spatial resolution, thus enhancing the capability of resolving closely spaced sources and reducing estimation errors. The present computer simulations show, in EEG 3D dipole source localization, that compared to classic MUSIC, FINES has (1) better resolvability of two closely spaced dipolar sources and (2) better estimation accuracy of source locations. In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist

  13. Reverse Flipping Technique: An Alternate Approach to Tie Reversing Half-Hitches on Alternating Posts.

    Science.gov (United States)

    Chong, Alexander C M; Prohaska, Daniel J; Pate, Ryan C

    2016-04-01

    Arthroscopic knot tying requires practice and attention to detail, especially tying the 3 reversing half-hitches on alternating posts (RHAPs) in a knot. Mistakes can occur that result in an unintentional tension (>10 N) applied to the wrapping suture limb, and by placing tension in the wrong limb, the previously "flipped" half-hitch is converted from a series of RHAPs into a series of identical half-hitches on the same post, thereby producing insecure knots or suture loops. This was hypothesized to be a source of knot failure by knot slippage. This error can be avoided by using a technique we describe as "reverse flipping," which purposely "flips" the half-hitch down at the main knot while tying the 3 RHAPs in a knot, and then the half-hitch is retightened using either a past-pointing or over-pointing technique. This way the surgeon can be absolutely sure that the half-hitch is tightened in the direction that it was intended to be placed, and can also prevent the unintentional tension applied to the wrapping suture limb that causes the half-hitch to "flip." However, caution should be used when tensioning the half-hitches; overtensioning (>40 N) during past-pointing or over-pointing could also potentially "flip" the previous half-hitch that has already been tightened and cause potential knot failure. PMID:27462541

  14. Alternative Approaches for Incentivizing the Frequency Responsive Reserve Ancillary Service

    Energy Technology Data Exchange (ETDEWEB)

    Ela, E.; Milligan, M.; Kirby, B.; Tuohy, A.; Brooks, D.

    2012-03-01

    Frequency responsive reserve is the autonomous response of generators and demand response to deviations of system frequency, usually as a result of the instantaneous outage of a large supplier. Frequency responsive reserve arrests the frequency decline resulting in the stabilization of system frequency, and avoids the triggering of under-frequency load-shedding or the reaching of unstable frequencies that could ultimately lead to system blackouts. It is a crucial service required to maintain a reliable and secure power system. Regions with restructured electricity markets have historically had a lack of incentives for frequency responsive reserve because generators inherently provided the response and on large interconnected systems, more than sufficient response has been available. This may not be the case in future systems due to new technologies and declining response. This paper discusses the issues that can occur without proper incentives and even disincentives, and proposes alternatives to introduce incentives for resources to provide frequency responsive reserve to ensure an efficient and reliable power system.

  15. The Mind-Body Connection - Complementary and Alternative Approaches to Health

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues The Mind-Body Connection Complementary and Alternative Approaches to Health ... To Find Out More At medlineplus.gov , type "mind-body" or "emotions" into the Search box. There ...

  16. An Alternative Approach to the Teaching of Systematic Transition Metal Chemistry.

    Science.gov (United States)

    Hathaway, Brian

    1979-01-01

    Presents an alternative approach to teaching Systematic Transition Metal Chemistry with the transition metal chemistry skeleton features of interest. The "skeleton" is intended as a guide to predicting the chemistry of a selected compound. (Author/SA)

  17. The Mind-Body Connection - Complementary and Alternative Approaches to Health

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues The Mind-Body Connection Complementary and Alternative Approaches to Health Past ... Find Out More At www.medlineplus.gov , type "mind-body" or "emotions" into the Search box. There is ...

  18. Alternate approaches to future electron-positron linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Loew, G.A. [Stanford Univ., CA (United States). Stanford Linear Accelerator Center

    1998-07-01

    The purpose of this article is two-fold: to review the current international status of various design approaches to the next generation of e{sup +}e{sup {minus}} linear colliders, and on the occasion of his 80th birthday, to celebrate Richard B. Neal`s many contributions to the field of linear accelerators. As it turns out, combining these two tasks is a rather natural enterprise because of Neal`s long professional involvement and insight into many of the problems and options which the international e{sup +}e{sup {minus}} linear collider community is currently studying to achieve a practical design for a future machine.

  19. An Intelligent Alternative Approach to the efficient Network Management

    Directory of Open Access Journals (Sweden)

    MARTÍN, A.

    2012-12-01

    Full Text Available Due to the increasing complexity and heterogeneity of networks and services, many efforts have been made to develop intelligent techniques for management. Network intelligent management is a key technology for operating large heterogeneous data transmission networks. This paper presents a proposal for an architecture that integrates management object specifications and the knowledge of expert systems. We present a new approach named Integrated Expert Management, for learning objects based on expert management rules and describe the design and implementation of an integrated intelligent management platform based on OSI and Internet management models. The main contributions of our approach is the integration of both expert system and managed models, so we can make use of them to construct more flexible intelligent management network. The prototype SONAP (Software for Network Assistant and Performance is accuracy-aware since it can control and manage a network. We have tested our system on real data to the fault diagnostic in a telecommunication system of a power utility. The results validate the model and show a significant improvement with respect to the number of rules and the error rate in others systems.

  20. An Alternative Approach to Data Acquisition Using Keyboard Emulation Technique

    CERN Document Server

    Khalid, Shahrukh

    2010-01-01

    A number of data acquisition systems depend on human interface to access computer for measuring, processing and analyzing data and to prepare it for presentation and storage. Data acquisition software is installed on the computer and all intended operations are performed manually. The data acquisition software requires user intervention for operations like selection of measurement setup, acquisition and storage of data to computer. The duty of users becomes laborious if the data acquisition process lasts for a long duration and requires continuous repetition of steps. An appropriate solution to overcome such problem is to replace the physical operator with a virtual user. This software generated simulated user sits at the data acquisition process through out and automate all the intended steps of data acquisition. This paper presents a new approach for data acquisition by using keyboard emulation technique. A keyboard emulation software is developed which runs beside the main data acquisition software and act...

  1. An alternative approach to tritium-in-water monitoring

    International Nuclear Information System (INIS)

    A paradigm shift in the approach to tritium-in-water monitoring is considered and its viability demonstrated through a series of proof-of-principle experiments. The fundamental difference in the proposed detection system consists of changing the state of the tritiated water from the liquid phase to the gas phase and subsequently using any one of a variety of detection methods to detect tritium in the water vapour. Proof-of-principle experiments using an un-optimized heated ionization chamber illustrate the viability of the proposed method. Operation of the experiment as a continuous in-line detection system shows a detection limit of ∼20 μCi/l, a detection time constant of 10 s, and simplicity and effectiveness of the overall system. It is projected that an optimized heated ionization chamber system using state-of-the-art current measuring circuitry, could yield a detection limit of ∼0.2 μCi/l. Furthermore, application of a more sensitive detection system (for example, the gas electron multiplier) is expected to result in additional gain in sensitivity. The advantages of the proposed tritium-in-water monitoring system are: high sensitivity with a detection limit beginning to approach current day batch liquid scintillation detection systems; a truly continuous, on-line tritium-in-water monitor with response time of less than tens of seconds; a detection system potentially applicable for multiple stream monitoring; a system that does not generate any waste; and, a system that overcomes the fouling issues associated with current day on-line LSC systems

  2. A unified approach to Mimetic Finite Difference, Hybrid Finite Volume and Mixed Finite Volume methods

    OpenAIRE

    Droniou, Jerome; Eymard,, Robert; Gallouët, Thierry; Herbin, Raphaele

    2008-01-01

    International audience We investigate the connections between several recent methods for the discretization of ani\\-so\\-tropic heterogeneous diffusion operators on general grids. We prove that the Mimetic Finite Difference scheme, the Hybrid Finite Volume scheme and the Mixed Finite Volume scheme are in fact identical up to some slight generalizations. As a consequence, some of the mathematical results obtained for each of the method (such as convergence properties or error estimates) may ...

  3. An alternative approach to tritium-in-water monitoring

    CERN Document Server

    Kherani, N P

    2002-01-01

    A paradigm shift in the approach to tritium-in-water monitoring is considered and its viability demonstrated through a series of proof-of-principle experiments. The fundamental difference in the proposed detection system consists of changing the state of the tritiated water from the liquid phase to the gas phase and subsequently using any one of a variety of detection methods to detect tritium in the water vapour. Proof-of-principle experiments using an un-optimized heated ionization chamber illustrate the viability of the proposed method. Operation of the experiment as a continuous in-line detection system shows a detection limit of approx 20 mu Ci/l, a detection time constant of 10 s, and simplicity and effectiveness of the overall system. It is projected that an optimized heated ionization chamber system using state-of-the-art current measuring circuitry, could yield a detection limit of approx 0.2 mu Ci/l. Furthermore, application of a more sensitive detection system (for example, the gas electron multipl...

  4. Setting Win Limits: An Alternative Approach to "Responsible Gambling"?

    Science.gov (United States)

    Walker, Douglas M; Litvin, Stephen W; Sobel, Russell S; St-Pierre, Renée A

    2015-09-01

    Social scientists, governments, and the casino industry have all emphasized the need for casino patrons to "gamble responsibly." Strategies for responsible gambling include self-imposed time limits and loss limits on gambling. Such strategies help prevent people from losing more than they can afford and may help prevent excessive gambling behavior. Yet, loss limits also make it more likely that casino patrons leave when they are losing. Oddly, the literature makes no mention of "win limits" as a potential approach to responsible gambling. A win limit would be similar to a loss limit, except the gambler would leave the casino upon reaching a pre-set level of winnings. We anticipate that a self-imposed win limit will reduce the gambler's average loss and, by default, also reduce the casino's profit. We test the effect of a self-imposed win limit by running slot machine simulations in which the treatment group of players has self-imposed and self-enforced win and loss limits, while the control group has a self-imposed loss limit or no limit. We find that the results conform to our expectations: the win limit results in improved player performance and reduced casino profits. Additional research is needed, however, to determine whether win limits could be a useful component of a responsible gambling strategy. PMID:24567070

  5. An Alternative Educational Approach for an Inorganic Chemistry Laboratory Course in Industrial and Chemical Engineering

    Science.gov (United States)

    Garces, Andres; Sanchez-Barba, Luis Fernando

    2011-01-01

    We describe an alternative educational approach for an inorganic chemistry laboratory module named "Experimentation in Chemistry", which is included in Industrial Engineering and Chemical Engineering courses. The main aims of the new approach were to reduce the high levels of failure and dropout on the module and to make the content match the…

  6. ALTERNATIVE AND COMPLEMENTARY SYNTHETIC APPROACHES TO β CARBOXY-α-METHYLENE-γ-BUTYROLACTONE ETHYL ESTERS

    Directory of Open Access Journals (Sweden)

    Gwenaëlle Liberge

    2011-12-01

    Full Text Available Alternative synthetic approaches to a variety of β substituted and carboxylated α-methylene-γ-butyrolactones have been developed. In the first approach the mandatory methylene unit was incorporated on precursor compounds at early stage of the synthesis on reliance with Horner-Emmons protocol. In the alternative approach which further tolerates multifarious substituents at γ-position of the lactone template the unsaturated moiety α to the lactone carbonyl group is connected at a later stage through a deprotonation / methoxymethylation / elimination sequence.

  7. Complementary and alternative approaches used by parents of children with epilepsy on epilepsy management.

    Science.gov (United States)

    Işler, Ayşegül; Turan, Fatma Dilek; Gözüm, Sebahat; Oncel, Selma

    2014-03-01

    The aim of this study was to determine the complementary and alternative approaches used by parents of children with epilepsy on epilepsy management. This descriptive study included a total of 304 parents of children with epilepsy aged between 0 and 18years evaluated at the Pediatric Neurology Clinic of Akdeniz University Hospital in Turkey between January and May 2013. Data were collected by using a questionnaire developed by the researchers. It was determined that all the parents use complementary and alternative approaches for their children with epilepsy, and the most common approaches are praying (99.3%); keeping their children away from the effects of smoking (79.8%); feeding their children walnuts (79.6%), butter (59.2%), and bone marrow (58.6%); providing their children with good quality sleep (58.6%); and enabling their children to play games (51%). The approaches commonly applied during seizures include praying (96.2%), comforting their children in their arms and showing affection (55.6%), waiting for seizures to finish at home (45.7%), and laying children on their side (41.1%). Of parents, 98% stated that alternative approaches enable them to control their child's seizures, 100% said that alternative approaches have no adverse effect, and 98.4% stated that they will continue to use these approaches. The children's approaches to cope with epilepsy included looking after pets (72.7%), listening to music (70.1%), watching television (64.5%), playing games (55.3%), praying (51%), and spending time with friends (48.7%). Most of the approaches used by parents and children with epilepsy for the management of illness are determined to consist of complementary approaches that may contribute to management of epilepsy. Knowing the approaches of parents and children with epilepsy that could adversely affect disease management is important for educating parents and children to avoid these potentially harmful interventions. PMID:24462737

  8. An alternative approach for teacher education framed by a collaborative partnership setting

    DEFF Research Database (Denmark)

    Pontoppidan, Birgitte Schou

    2010-01-01

    The study presents an alternative didactical approach to teacher education linking practice and theory through a collaborative partnership setting. Using a ―small scale teaching design in which students alternate between schools and college it was possible to show someevidence that, by following...... this approach, first year student teachers in a science & technology class developed teacher knowledge (as aspects of PCK). The study identifies an example using Co-Re and PaPeR as a Resource Folio to show where evidence of developing teacher knowledge is seen. This didactical approach turns the...... traditional teacher education on its head and begins with a focus on practice so students alternate between school–based and college–based teaching in a cyclical fashion, and are encouraged to link theory with practice. This kind of college teaching demands a new teacher educational paradigm for which...

  9. Spreadsheet Assurance by "Control Around" is a Viable Alternative to the Traditional Approach

    CERN Document Server

    Ettema, Harmen; de Swart, Jacques

    2008-01-01

    The traditional approach to spreadsheet auditing generally consists of auditing every distinct formula within a spreadsheet. Although tools are developed to support auditors during this process, the approach is still very time consuming and therefore relatively expensive. As an alternative to the traditional "control through" approach, this paper discusses a "control around" approach. Within the proposed approach not all distinct formulas are audited separately, but the relationship between input data and output data of a spreadsheet is audited through comparison with a shadow model developed in a modelling language. Differences between the two models then imply possible errors in the spreadsheet. This paper describes relevant issues regarding the "control around" approach and the circumstances in which this approach is preferred above a traditional spreadsheet audit approach.

  10. Final cost reduction study for the Geysers Recharge Alternative. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The purpose of this study is to determine whether or not cost reduction opportunities exist for the Geysers Recharge Alternative as defined in the Santa Rosa Subregional Long-Term Wastewater Project EIR/EIS. The City of Santa Rosa has been directed to have a plan for reclaimed water disposal in place by 1999 which will meet future capacity needs under all weather conditions. A Draft EIR/EIS released in July 1996 and a Final EIR certified in June 1997 examine four primary alternatives plus the No Action Alternative. Two of the primary alternatives involve agricultural irrigation with reclaimed water, either in western or southern Sonoma County. Another involves increased discharge of reclaimed water into the Russian River. The fourth involves using reclaimed water to replenish the geothermal reservoir at the Geysers. The addition of this water source would enable the Geysers operators to produce more steam from the geothermal area and thereby prolong the life and economic production level of the steamfield and the geothermal power plants supplied by the steamfield. This study provides additional refined cost estimates for new scenarios which utilize an alternative pipeline alignment and a range of reclaimed water flows, which deliver less water to the Geysers than proposed in the EIR/EIS (by distributing flow to other project components). Also, electrical power rates were revised to reflect the recent changes in costs associated with deregulation of the power industry. In addition, this report provides information on sources of potential public and private funding available and future environmental documentation required if the cost reduction scenarios were to be selected by the City as part of their preferred alternative.

  11. Ion Recognition Approach to Volume Reduction of Alkaline Tank Waste by Separation and Recycle of Sodium Hydroxide and Sodium Nitrate

    International Nuclear Information System (INIS)

    This research was intended to provide the scientific foundation upon which the feasibility of liquid-liquid extraction chemistry for bulk reduction of the volume of high-activity tank waste can be evaluated. Primary focus has been on sodium hydroxide separation, with potential Hanford application. Value in sodium hydroxide separation can potentially be found in alternative flowsheets for treatment and disposal of low-activity salt waste. Additional value can be expected in recycle of sodium hydroxide for use in waste retrieval and sludge washing, whereupon additions of fresh sodium hydroxide to the waste can be avoided. Potential savings are large both because of the huge cost of vitrification of the low-activity waste stream and because volume reduction of high-activity wastes could obviate construction of costly new tanks. Toward these ends, the conceptual development begun in the original proposal was extended with the formulation of eight fundamental approaches that could be undertaken for extraction of sodium hydroxide

  12. Draft Programmatic Environmental Impact Statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 2: Appendices

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky; Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. The preferred alternative for the long-term management of depleted UF6 is to use the entire inventory of material. This volume contains the appendices to volume I

  13. Data summary of municipal solid waste management alternatives. Volume 4, Appendix B: RDF technologies

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix contains background information, technical descriptions, economic data, mass and energy balances, and information on environmental releases for the refuse derived fuels (RDF) option in municipal solid waste management alternatives. Demonstration programs at St. Louis, Missouri; Franklin, Ohio; and Delaware are discussed. Information on pellet production and cofiring with coal is also presented.

  14. Data summary of municipal solid waste management alternatives. Volume 11, Alphabetically indexed bibliography

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix contains the alphabetically indexed bibliography for the complete group of reports on municipal waste management alternatives. The references are listed for each of the following topics: mass burn technologies, RDF technologies, fluidized-bed combustion, pyrolysis and gasification of MSW, materials recovery- recycling technologies, sanitary landfills, composting, and anaerobic digestion of MSW.

  15. Data summary of municipal solid waste management alternatives. Volume 12, Numerically indexed bibliography

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix contains the numerically indexed bibliography for the complete group of reports on municipal solid waste management alternatives. The list references information on the following topics: mass burn technologies, RDF technologies, fluidized bed combustion, pyrolysis and gasification of MSW, materials recovery- recycling technologies, sanitary landfills, composting and anaerobic digestion of MSW.

  16. Joint 3D inversion of gravity and magnetic data with geological constraints - an alternative approach

    Science.gov (United States)

    Prutkin, Ilya; Vajda, Peter; Jentzsch, Gerhard

    2016-04-01

    Quite a popular approach now by interpretation of gravity data is a linear one - an attempt is made to find a density distribution d(x,y,z) below the Earth's surface. This approach has clear disadvantages. First, we face the problem of dimensionality: one looks for 3D function based on 2D data set (measurements on the Earth's surface), the degree of non-uniqueness is extremely high, and no regularization can save the situation. The number of unknowns is many times higher than the number of observations; otherwise, we obtain a very rough model of the lower half-space. Second, the linear approach is not reasonable from the geological point of view. It implies that density varies from one point to another. Usually, we assume big volumes with nearly homogeneous density - layers, blocks, intrusions. It looks more understandable, to search for geometry of density interfaces: 3D topography of contact surfaces and shapes of restricted bodies (intrusions). Third, in the framework of the linear approach even for a synthetic field of two separate objects we obtain clouds of points with slightly increased density. It is hardly ever possible, to isolate objects, particularly when one of them is located above another one. We suggest an alternative approach for the linear one. Our approach has been successfully applied for several case histories including a local gravity anomaly Kolarovo and a bigger area of the Thuringian Basin, where both gravity and magnetic data are inverted. First, we separate sources into deep, intermediate and shallow ones, using subsequent upward and downward continuation. All components are inverted separately. We address a problem which we name the problem of low frequencies: deep objects generate long wavelengths, but the converse implication is not necessarily true. For instance, the effect of the basin structure contributes substantially into low frequencies, though it is caused by shallow sources. However, our numerical experiments with intermediate

  17. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    International Nuclear Information System (INIS)

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations

  18. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    International Nuclear Information System (INIS)

    This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

  19. Generalized Navier Boundary Condition for a Volume Of Fluid approach using a Finite-Volume method

    CERN Document Server

    Boelens, A M P

    2016-01-01

    In this work, an analytical Volume Of Fluid (VOF) implementation of the Generalized Navier Boundary Condition is presented based on the Brackbill surface tension model. The model is validated by simulations of droplets on a smooth surface in a planar geometry. Looking at the static behavior of the droplets, it is found that there is a good match between the droplet shape resolved in the simulations and the theoretically predicted shape for various values of the Young's angle. Evaluating the spreading of a droplet on a completely wetting surface, the Voinov-Tanner-Cox law ($\\theta \\propto \\text{Ca}^{1/3}$) can be observed. At later times scaling follows $r \\propto t^{1/2}$, suggesting spreading is limited by inertia. These observations are made without any fitting parameters except the slip length.

  20. Assessment of management alternatives for LWR wastes. Volume 1. Main achievements of the joint study

    International Nuclear Information System (INIS)

    This report deals with the main achievements of a joint theoretical study aimed at evaluating a selection of management routes for LWR wastes, relying to a certain extent on national practices in this particular area, on the basis of economical and radiological criteria. All individual intermediate steps entering a management route, from radioactive-wastes production up to their disposal in near-surface sites or in a deep repository, have been identified, described and cost-evaluated throughout the study. The radiological impact assessment comprises estimates of both individual and collective doses resulting from normal discharges of radioactive effluents and from disposal of radioactive waste products in near-surfaces sites. All specific data concerning the description of the different management routes considered as well as the methodology applied to evaluate cost and radiological impact are detailed in the subsequent volumes of the series (Volumes 2 to 8)

  1. K Basin spent fuel sludge treatment alternatives study. Volume 2, Technical options

    International Nuclear Information System (INIS)

    Approximately 2100 metric tons of irradiated N Reactor fuel are stored in the KE and KW Basins at the Hanford Site, Richland, Washington. Corrosion of the fuel has led to the formation of sludges, both within the storage canisters and on the basin floors. Concern about the degraded condition of the fuel and the potential for leakage from the basins in proximity to the Columbia River has resulted in DOE's commitment in the Tri-Party Agreement (TPA) to Milestone M-34-00-T08 to remove the fuel and sludges by a December 2002 target date. To support the planning for this expedited removal action, the implications of sludge management under various scenarios are examined. This report, Volume 2 of two volumes, describes the technical options for managing the sludges, including schedule and cost impacts, and assesses strategies for establishing a preferred path

  2. A Half-Flipped Classroom or an Alternative Approach?: Primary Sources and Blended Learning

    Science.gov (United States)

    Westermann, Edward B.

    2014-01-01

    This paper examines an alternate approach to the "flipped" classroom paradigm for an upper level history class using a blended on-line and in-class format. The concept of the flipped classroom has received increasing emphasis based on its potential to create a student-centered learning environment that incorporates practical instruction…

  3. What Can We Learn from Chaos Theory? An Alternative Approach to Instructional Systems Design.

    Science.gov (United States)

    You, Yeongmahn

    1993-01-01

    Explains chaos theory; compares a conventional instructional systems design (ISD) approach with chaos theory and dynamic nonlinear systems, including deterministic predictability and indeterministic unpredictability and negative and positive feedback; explores theoretical implications for developing an alternative ISD model; and recommends future…

  4. The Declining Suitability of the Formula Approach to Funding Fublic Higher Education: Rationale and Alternatives.

    Science.gov (United States)

    Temple, Charles M.; Riggs, Robert O.

    1978-01-01

    After discussing and analyzing three available alternative budgeting approaches, including incremental, program budgeting, and zero-based budgeting, this article suggests the criteria necessary for a newly adapted system and contends that a program budgeting system would serve most effectively. (DS)

  5. Point patterns occurring on complex structures in space and space-time: An alternative network approach

    CERN Document Server

    Eckardt, Matthias

    2016-01-01

    This paper presents an alternative approach of analyzing possibly multitype point patterns in space and space-time that occur on network structures, and introduces several different graph-related intensity measures. The proposed formalism allows to control for processes on undirected, directional as well as partially directed network structures and is not restricted to linearity or circularity.

  6. Alternative scenarios for Federal transportation policy. Volume I. Summary. First year final report

    Energy Technology Data Exchange (ETDEWEB)

    Friedlaender, A.; Simpson, R.

    1977-01-01

    A summary is given of research evaluating the economic effects of existing and prospective federal policies governing intercity and international freight and passenger transportation enterprises in the economy of the United States. The analysis encompasses all modes of transportation, including rail, motor, water, air and intermodal coordinative institutions, and focuses upon the impact of alternative regulatory policies. However, other federal policies including subsidy, taxation, procurement, government ownership and investment, special programs for particular transportation industry problems and impacts of general national policies on transportation will be included when relevant. Economic evaluation includes the study of efficient resource allocation and distributional effects of alternative policies together with consideration of both partial and general equilibrium effects. The research is interdisciplinary in scope, drawing upon engineering, economics, statistics, law and administration.

  7. Waste management project’s alternatives: A risk-based multi-criteria assessment (RBMCA) approach

    International Nuclear Information System (INIS)

    Highlights: ► We examine the evaluation of a waste management project’s alternatives. ► We present a novel risk-based multi-criteria assessment (RBMCA) approach. ► In the RBMCA the evaluation criteria are based on the quantitative risk analysis of the project’s alternatives. ► Correlation between the criteria weight values and the decision makers’ risk preferences is examined. ► Preference to the multi-criteria against the one-criterion evaluation process is discussed. - Abstract: This paper examines the evaluation of a waste management project’s alternatives through a quantitative risk analysis. Cost benefit analysis is a widely used method, in which the investments are mainly assessed through the calculation of their evaluation indicators, namely benefit/cost (B/C) ratios, as well as the quantification of their financial, technical, environmental and social risks. Herein, a novel approach in the form of risk-based multi-criteria assessment (RBMCA) is introduced, which can be used by decision makers, in order to select the optimum alternative of a waste management project. Specifically, decision makers use multiple criteria, which are based on the cumulative probability distribution functions of the alternatives’ B/C ratios. The RBMCA system is used for the evaluation of a waste incineration project’s alternatives, where the correlation between the criteria weight values and the decision makers’ risk preferences is analyzed and useful conclusions are discussed.

  8. Typological Approaches to Violence in Couples: A Critique and Alternative Conceptual Approach

    OpenAIRE

    Capaldi, Deborah M.; Kim, Hyoun K.

    2006-01-01

    Typological approaches have become highly influential in research on violence in couples, and yet issues related to such approaches have not been well addressed. We review the utility of batterer typologies, both for clinical applications and for understanding violence in couples. The principal types of batterer typologies are discussed, along with a number of issues that might limit their utility for explaining the etiology and developmental course of partner violence in couples. We propose ...

  9. Minimally invasive and alternative approaches for long-term LVAD placement: the Vanderbilt strategy

    Science.gov (United States)

    Davis, Mary E.; Haglund, Nicholas

    2014-01-01

    Background Minimally invasive and alternative strategies for implantation have been anecdotally reported for contemporary continuous-flow left ventricular assist device (CF-LVAD) placement. Methods We reviewed our experience at a single center with alternative strategies for implantation of the HeartMate II and HeartWare CF-LVADs, in patients with advanced heart failure (HF). This featured article focuses on the associated surgical techniques and patient management pitfalls. Results For appropriately selected cases, our group believes that these alternative strategies allow for the development of novel and less traumatic surgical approaches for CF-LVAD implantation. With reproducible outcomes, these approaches also promise the possibility of increasing the number of high-risk surgical patients who could benefit from CF-LVAD therapies. Conclusions This work has detailed a variety of less invasive alternative strategies for implantation of long-term LVADs. These newer approaches have the potential for significant advancements in the field of cardiothoracic surgery. Large-scale collaborative studies will be needed to clarify the potential advantages and disadvantages of these novel techniques on patient outcomes. PMID:25512895

  10. The Design of Treatment Wetlands in the United Kingdom: Successes, Failures, and Alternative Approaches

    Institute of Scientific and Technical Information of China (English)

    SUN Guangzhi; ZHANG Guangxin

    2008-01-01

    Constructed wetland was first introduced into the United Kingdom in the middle of 1980s, following a visit by a group of scientist to Western Germany. In the past 2 decades, the applications of constructed wetlands in this country have expanded substantially, due to the demand for green technologies and rising cost of fossil fuel energies. This paper reported a statistical investigation of the performances of 78 horizontal flow wetlands, representatives of such system in the United Kingdom. Alternative design equations, based on organic matter removal efficiency, have been developed from Monod kinetics, and the accuracy and reliability of current and alternative design approaches have been examined.

  11. Alternative Endpoints and Approaches for the Remediation of Contaminated Groundwater at Complex Sites - 13426

    International Nuclear Information System (INIS)

    The goal of United States (U.S.) Department of Energy's (DOE)'s environmental remediation programs is to restore groundwater to beneficial use, similar to many other Federal and state environmental cleanup programs. Based on past experience, groundwater remediation to pre-contamination conditions (i.e., drinking water standards or non-detectable concentrations) can be successfully achieved at many sites. At a subset of the most complex sites, however, complete restoration is not likely achievable within the next 50 to 100 years using today's technology. This presentation describes several approaches used at complex sites in the face of these technical challenges. Many complex sites adopted a long-term management approach, whereby contamination was contained within a specified area using active or passive remediation techniques. Consistent with the requirements of their respective environmental cleanup programs, several complex sites selected land use restrictions and used risk management approaches to accordingly adopt alternative cleanup goals (alternative endpoints). Several sites used long-term management designations and approaches in conjunction with the alternative endpoints. Examples include various state designations for groundwater management zones, technical impracticability (TI) waivers or greater risk waivers at Superfund sites, and the use of Monitored Natural Attenuation (MNA) or other passive long-term management approaches over long time frames. This presentation will focus on findings, statistics, and case studies from a recently-completed report for the Department of Defense's Environmental Security Technology Certification Program (ESTCP) (Project ER-0832) on alternative endpoints and approaches for groundwater remediation at complex sites under a variety of Federal and state cleanup programs. The primary objective of the project was to provide environmental managers and regulators with tools, metrics, and information needed to evaluate

  12. Alternative fuels for vehicles fleet demonstration program final report. Volume 1: Summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The Alternative Fuels for Vehicles Fleet Demonstration Program (AFV-FDP) was a multiyear effort to collect technical data for use in determining the costs and benefits of alternative-fuel vehicles in typical applications in New York State. During 3 years of collecting data, 7.3 million miles of driving were accumulated, 1,003 chassis-dynamometer emissions tests were performed, 862,000 gallons of conventional fuel were saved, and unique information was developed about garage safety recommendations, vehicle performance, and other topics. Findings are organized by vehicle and fuel type. For light-duty compressed natural gas (CNG) vehicles, technology has evolved rapidly and closed-loop, electronically-controlled fuel systems provide performance and emissions advantages over open-loop, mechanical systems. The best CNG technology produces consistently low tailpipe emissions versus gasoline, and can eliminate evaporative emissions. Reduced driving range remains the largest physical drawback. Fuel cost is low ($/Btu) but capital costs are high, indicating that economics are best with vehicles that are used intensively. Propane produces impacts similar to CNG and is less expensive to implement, but fuel cost is higher than gasoline and safety codes limit use in urban areas. Light-duty methanol/ethanol vehicles provide performance and emissions benefits over gasoline with little impact on capital costs, but fuel costs are high. Heavy-duty CNG engines are evolving rapidly and provide large reductions in emissions versus diesel. Capital costs are high for CNG buses and fuel efficiency is reduced, but the fuel is less expensive and overall operating costs are about equal to those of diesel buses. Methanol buses provide performance and emissions benefits versus diesel, but fuel costs are high. Other emerging technologies were also evaluated, including electric vehicles, hybrid-electric vehicles, and fuel cells.

  13. Hanford Spent Nuclear Fuel Project: Recommended path forward. Volume 2: Alternatives and path forward evaluation

    International Nuclear Information System (INIS)

    The Hanford Spent Nuclear Fuel Project has completed an evaluation of four alternatives for expediting the removal of spent nuclear fuel from the K Basins and stabilizing and placing the fuel into interim storage. Four alternatives were compared: (1) Containerizing fuel in the K Basins, transporting fuel to a facility for stabilization, and interim storage of stabilized fuel in a dry storage facility (DSF); (2) Containerizing fuel in the K Basins, transporting fuel to a wet temporary staging facility, moving fuel to a facility for stabilization, and transporting stabilized fuel to an interim DSF; (3) Containerizing fuel in the K Basins in multi-canister overpacks, transporting fuel directly to a stabilization facility for passivation in the overpack, and interim storage of stabilized fuel in a DSF; (4) Packaging fuel for transport overseas and shipping fuel to a foreign reprocessing facility for reprocessing with eventual return of U, Pu and vitrified high level waste. The comparative evaluation consisted of a multi-attribute utility decision analysis, a public, worker and environmental health risk assessment, and a programmatic risk evaluation. The evaluation concluded that the best Path Forward combines the following concepts: Removal of K Basin fuel and sludge is uncoupled from the operation of a stabilization facility; A storage capability is provided to act as a lag storage or staging operation for overpack fuel containers as they are removed from the K Basins; Metal fuel drying and passivation should be maintained as the fuel stabilization process with the option of further refinements as more information becomes available; and The near term NEPA strategy should focus on expeditious removal of fuel and sludge from K Basins and placing overpacked fuel in temporary storage

  14. AN ALTERNATIVE APPROACH FOR TEACHER EDUCATION COURSES FRAMED BY A COLLABORATE PARTNERSHIP

    DEFF Research Database (Denmark)

    Pontoppidan, Birgitte

    2010-01-01

    The study presents an alternative didactical approach to teacher education linking practice and theory through a collaborative partnership setting. Using a “small scale” teaching design in which students alternate between schools and college it was possible to show some evidence that, by following...... traditional teacher education on its head and begins with a focus on practice so students alternate between school–based and college–based teaching in a cyclical fashion, and are encouraged to link theory with practice. This kind of college teaching demands a new teacher educational paradigm for which...... collaboration between schools and colleges is paramount. This study indicates that a collaborative partnership setting involving college and S&T- profile schools can provide a “room for study”, and that this kind of teaching design enhances the opportunities for students’ to develop teacher knowledge (aspects...

  15. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    International Nuclear Information System (INIS)

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations. While any final assessment of such measures and alternatives would have to examine the circumstances particular to each nation, it is hoped that the more generic assessments conducted here will be useful in suggesting guidelines for developing an improved nonproliferation regime which also helps to meet nuclear-energy needs. One chapter outlines the existing nonproliferation regime, including the Treaty for the Non-Proliferation of Nuclear Weapons (NPT), International Atomic Energy Agency (IAEA) safeguards, bilateral and multilateral requirements for agreements of cooperation and transfers of technology, and existing provisons for sanctions for violation of nonproliferation commitments. The chapter then proceeds to an assessment of various alternatives for providing assurance of fuel supply in light of this current regime. Another chapter examines a set of technical and institutional measures and alternatives for various components of once-through and closed fuel cycles. The components of the once-through fuel cycle assessed are enrichment services and spent-fuel management; the components of closed fuel cycles assessed are reprocessing and plutonium management and fast-breeder reactor (FBR) deployment

  16. Optical approach for the efficient data volume handling in experimentally encrypted data

    International Nuclear Information System (INIS)

    Experimental optical procedures generate a tremendous amount of data, which must be then processed for any practical application. We present a new optical approach in terms of the data volume for the efficient handling of multiple data obtained from an experimental cryptosystem. In order to achieve this goal, we use the combination of optical filtering and optical scaling of the experimentally registered data. The intention is to reduce by optical means the amount of data to be managed. We define a so called ‘efficiency factor’ to describe the effectiveness of the approach. We find that volume reduction depends on this factor and the number of objects to be processed. We achieved substantial data volume reductions up to 94.24%. We introduce the basic concepts as well as experimental results that support both the feasibility and the applicability of our approach. (paper)

  17. Optical approach for the efficient data volume handling in experimentally encrypted data

    Science.gov (United States)

    Trejos, Sorayda; Fredy Barrera, John; Velez, Alejandro; Tebaldi, Myrian; Torroba, Roberto

    2016-06-01

    Experimental optical procedures generate a tremendous amount of data, which must be then processed for any practical application. We present a new optical approach in terms of the data volume for the efficient handling of multiple data obtained from an experimental cryptosystem. In order to achieve this goal, we use the combination of optical filtering and optical scaling of the experimentally registered data. The intention is to reduce by optical means the amount of data to be managed. We define a so called ‘efficiency factor’ to describe the effectiveness of the approach. We find that volume reduction depends on this factor and the number of objects to be processed. We achieved substantial data volume reductions up to 94.24%. We introduce the basic concepts as well as experimental results that support both the feasibility and the applicability of our approach.

  18. Multi-criteria Planning Approach for Ranking of Land Management Alternatives at Different Spatial Scales

    Directory of Open Access Journals (Sweden)

    M. Reza Ghanbarpour

    2011-03-01

    Full Text Available Integrated land management decisions require comprehensive sets of criteria in order to properly account for all managerial alternatives. Economic criteria have been used to evaluate possible alternatives in most cases. However, it is important to consider the broadest possible range of social, economic and environmental criteria. This paper describes an integrated framework for land management planning at different spatial scales, comprising watershed, sub-watershed and land-unit levels. The structure includes four elements: (1 application of the strategic land management planning approach using the Delphi method and group decision analysis at sub-w atershed scales, (2 identification of decision criteria at the land unit scale using socio-economic analysis and hydrologic modelling, (3 multi-criteria decision analysis of different alternatives, and (4 multi-stakeholder alternative prioritization. The Kan watershed north of Tehran, Iran, was selected as a case study. The major objective of this research is to integrate quantitative and qualitative decision criteria for planning purposes. This approach can be adapted to prioritize a w ide variety of land and water resources management decisions in similar watersheds.

  19. An alternative to the standard spatial econometric approaches in hedonic house price models

    DEFF Research Database (Denmark)

    Veie, Kathrine Lausted; Panduro, Toke Emil

    Hedonic models are subject to spatially correlated errors which are a symptom of omitted spatial variables, mis-specification or mismeasurement. Methods have been developed to address this problem through the use of spatial econometrics or spatial fixed effects. However, often spatial correlation...... is modeled without much consideration of the theoretical implications of the chosen model or treated as a nuisance to be dealt with holding little interest of its own. We discuss the limitations of current standard spatial approaches and demonstrate, both empirically and theoretically the generalized...... additive model as an alternative. The generalized additive model is compared with the spatial error model and the fixed effects model. We find the generalized additive model to be a solid alternative to the standard approaches, having less restrictive assumptions about the omitted spatial processes while...

  20. Developing countries and academic education in nuclear sciences: an alternative approach

    International Nuclear Information System (INIS)

    Whilst excellent training in nuclear sciences is available in some developing countries, this is not the case in the majority. The paper considers an approach to training which is an alternative to copying established schemes in advanced countries. Science students at undergraduate level should be obliged to attend a course on atomic and nuclear physics, with some variation in emphasis, depending on the student's main field of study. For postgraduates, it is suggested that there should be a two year course. In the first year there should be a single course on Nuclear Techniques and Methods, for all postgraduate students of nuclear physics. This course should have a practical emphasis. In the second year, students will specialize, will be assigned additional topics to study, a thesis topic, and a supervisor. The paper concludes by discussing the advantages and disadvantages of such an alternative approach. (author)

  1. Alternative strategies to reduce cost and waste volume in HEPA filtration using metallic filter media - 59348

    International Nuclear Information System (INIS)

    Document available in abstract form only. Full text of publication follows: The disposal costs of contaminated HEPA and THE filter elements have been proved to be disproportionately high compared with the cost of the elements themselves. Work published elsewhere (Moore, et el 1992; Bergman et al 1997) suggests that the cost of use of traditional, panel type, glass fibre HEPA filtration trains to the DOE was, during that period, $29.5 million, based on a five year life cycle, and including installation, testing, removal and disposal life cycle costs being based on estimates dating from 1987-1990. Within that cost estimate, $300 was the value given to the filter and $4, 450 was given to the peripheral activity. Clearly, if the $4, 450 component could be reduced, tremendous saving could ensue, in addition to the reduction of the legacy burden of waste volume. This issue exists for operators in both the US and in Europe. If HEPA filters could be cleaned to a condition where they could either be re-used or decontaminated to the extent that they could be stored as a lower cost wasteform or if HEPA/THE filter elements were available without any organic content likely to give rise to flammable or explosive decomposition gases during long term storage this would also reduce the costs and monitoring necessary in storage. (author)

  2. An alternative to the standard spatial econometric approaches in hedonic house price models

    DEFF Research Database (Denmark)

    von Graevenitz, Kathrine; Panduro, Toke Emil

    2015-01-01

    Omitted, misspecified, or mismeasured spatially varying characteristics are a cause for concern in hedonic house price models. Spatial econometrics or spatial fixed effects have become popular ways of addressing these concerns. We discuss the limitations of standard spatial approaches to hedonic...... modeling and demonstrate the spatial generalized additive model as an alternative. Parameter estimates for several spatially varying regressors are shown to be sensitive to the scale of the fixed effects and bandwidth dimension used to control for omitted variables. This sensitivity reflects...

  3. Docility and “through doing” morality: An alternative approach to ethics

    OpenAIRE

    Magnani Lorenzo; Bardone Emanuele; Secchi Davide

    2006-01-01

    In this paper, we aim at presenting the distributed morality approach as it can be described by the docility model of social interactions. The proposition “morality is a matter of social interaction” constitutes our starting point. We aim at pointing out the ways through which individuals create moral alternatives to a given situation. The paper is dedicated to presenting morality as something connected to human cognition. We introduce a “manipulative” way of thinking about morality, and we a...

  4. Strategies for laboratory HIV testing: an examination of alternative approaches not requiring Western blot.

    OpenAIRE

    Sato, P. A.; Maskill, W. J.; Tamashiro, H.; Heymann, D L

    1994-01-01

    Advances in laboratory tests for antibodies to human immunodeficiency virus (HIV) have permitted the development of alternative HIV testing strategies that do not require use of the Western blot approach. Three strategies are proposed. In strategy I, sera are tested for HIV antibody using an enzyme-linked immunosorbent assay (ELISA)/rapid/simple (ERS) test; in strategy II, sera reactive in an initial ERS test are retested using a second ERS test; strategy III involves retesting with a third E...

  5. Stabilization of Pt Nanoparticles with Amine Ligands : an Alternative Approach to Supporting Nanoparticles for Catalytic Applications

    OpenAIRE

    Morsbach, Eva

    2014-01-01

    The state-of-the-art approach to stabilize nanoparticles (NPs) for heterogeneous phase applications is to support them on inert inorganic material, which is limited to low loadings of the catalytic compund. However, applications such as thermoelectric gas sensing require a high density of catalytically active sites at a low total heat capacity. To offer an alternative to the supporting of NPs, in this work the stabilization of catalytic NPs as solids with organic ligands was investigated. Mon...

  6. Nudges to Privacy Behaviour: Exploring Alternative Approaches to EU Data Protection Regulation

    OpenAIRE

    Shara Monteleone; Rene van Bavel; Nuria Rodríguez-Priego; Gabriele Esposito

    2015-01-01

    The report seeks to bring behavioural research methods for privacy to the attention of EU policy-makers. It argues that changes in web interface design can be a useful policy alternative to the traditional 'privacy notice' approach. Specifically, it examines whether web interface design has effect on people's online privacy behaviour through an online experiment (n=3229) in four European countries. Results show that the presence of an anthropomorphic character leads to greater disclosure of p...

  7. An Alternative Approach to Control Measurements of Crane Rails

    OpenAIRE

    Dušan Kogoj; Aleš Marjetič; Klemen Kregar; Tomaž Ambrožič

    2012-01-01

    Horizontal and vertical positions of points for the control assessment of crane rails are classically determined separately. The procedure is time consuming and causes non-homogenous accuracy of the horizontal and vertical position of control points. The proposed alternative approach is based on polar measurements using a high accuracy total station instrument and a special platform with two precise surveying prisms fixed on it. Measurements are carried out from a single station thus ensuring...

  8. Anterior sagittal anorectoplasty: An alternative to posterior approach in management of congenital vestibular fistula

    OpenAIRE

    Man Mohan Harjai; Navdeep Sethi; Naveen Chandra

    2013-01-01

    Background: Better exposure, possibility of extension if needed and precise placement of the anal canal within the external sphincter complex have made the posterior and anterior sagittal approaches more popular and established for the correction of anovestibular fistula. The mini posterior sagittal anorectoplasty (PSARP) was the procedure of choice for female ARM at our center till date. As an alternative surgical option, we performed anterior sagittal anorectoplasty (ASARP) in 15 cases of a...

  9. Alternative approach for Article 5. Energie Efficiency Directive; Alternatieve aanpak artikel 5. Energy Efficiency Directive

    Energy Technology Data Exchange (ETDEWEB)

    Menkveld, M.; Jablonska, B. [ECN Beleidsstudies, Petten (Netherlands)

    2013-05-15

    Article 5 of the Energy Efficiency Directive (EED) is an annual obligation to renovate 3% of the building stock of central government. After renovation the buildings will meet the minimum energy performance requirements laid down in Article 4 of the EPBD. The Directive gives room to an alternative approach to achieve the same savings. The Ministry of Interior Affairs has asked ECN to assist with this alternative approach. ECN calculated what saving are achieved with the 3% renovation obligation under the directive. Then ECN looked for the possibilities for an alternative approach to achieve the same savings [Dutch] In artikel 5 van de Energie Efficiency Directive (EED) staat een verplichting om jaarlijks 3% van de gebouwvoorraad van de centrale overheid te renoveren. Die 3% van de gebouwvoorraad moet na renovatie voldoen aan de minimum eisen inzake energieprestatie die door het betreffende lidstaat zijn vastgelegd op grond van artikel 4 in de EPBD. De verplichting betreft gebouwen die in bezit en in gebruik zijn van de rijksoverheid met een gebruiksoppervlakte groter dan 500 m{sup 2}, vanaf juli 2015 groter dan 250 m{sup 2}. De gebouwen die eigendom zijn van de Rijksgebouwendienst betreft kantoren van rijksdiensten, gerechtsgebouwen, gebouwen van douane en politie en gevangenissen. Van de gebouwen van Defensie hoeven alleen kantoren en legeringsgebouwen aan de verplichting te voldoen.

  10. Alaska Regional Energy Resources Planning Project. Phase 2: coal, hydroelectric and energy alternatives. Volume I. Beluga Coal District Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rutledge, G.; Lane, D.; Edblom, G.

    1980-01-01

    This volume deals with the problems and procedures inherent in the development of the Beluga Coal District. Socio-economic implications of the development and management alternatives are discussed. A review of permits and approvals necessary for the initial development of Beluga Coal Field is presented. Major land tenure issues in the Beluga Coal District as well as existing transportation routes and proposed routes and sites are discussed. The various coal technologies which might be employed at Beluga are described. Transportation options and associated costs of transporting coal from the mine site area to a connecting point with a major, longer distance transportation made and of transporting coal both within and outside (exportation) the state are discussed. Some environmental issues involved in the development of the Beluga Coal Field are presented. (DMC)

  11. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VIII. Advanced concepts

    International Nuclear Information System (INIS)

    The goal of the Nonproliferation Alternative Systems Assessment Program has been to provide recommendations for the development and deployment of more proliferation-resistant civilian nuclear-power systems without jeopardizing the development of nuclear energy. In principle, new concepts for nuclear-power systems could be designed so that materials and facilities would be inherently more proliferation-resistant. Such advanced, i.e., less-developed systems, are the subject of this volume. Accordingly, from a number of advanced concepts that were proposed for evaluation, six representative concepts were selected: the fast mixed-spectrum reactor; the denatured molten-salt reactor; the mixed-flow gaseous-core reactor; the linear-accelerator fuel-regenerator reactor; the ternary metal-fueled electronuclear fuel-producer reactor; and the tokamak fusion-fission hybrid reactor

  12. Implementation of an approach to replacing the construction hydrostatic test with an alternative integrity validation

    Energy Technology Data Exchange (ETDEWEB)

    Glover, Alan; Purcell, Jennifer; Rudge, Paul; Hudson, Bob [TransCanada PipeLines Ltd., Toronto (Canada)

    2005-07-01

    Hydrostatic testing has been an accepted method of verifying the integrity of newly constructed pipelines prior to putting them in-service since the mid 1950s. Since that time many things have changed that have reduced the incidence of hydrostatic test failures both during the strength and leak testing portion. Critical to these changes have been improvements in pipeline design, materials and construction technology. Using these advancements TransCanada developed an Alternative Integrity Validation (AIV) approach that could be used to replace the field hydrostatic test on natural gas pipelines. This process was validated with key stake holders and the regulatory body (Alberta Energy Utilities Board) and experimental approval was given to apply the approach on a recent pipeline project. The paper will describe the background to the approach, the AIV process and its successful application on an onshore pipeline project completed in March 2005. The paper will also describe the current limitations in applying the approach and path forward. (author)

  13. Ion Recognition Approach to Volume Reduction of Alkaline Tank Waste by Separation and Recycle of Sodium Hydroxide and Sodium Nitrate

    International Nuclear Information System (INIS)

    Disposal of high-level nuclear waste is horrendously expensive, in large part because the actual radioactive matter in the tanks has been diluted over 1000-fold by ordinary inorganic chemicals. Treatment processes themselves can exacerbate the problem by adding further volume to the waste. Waste retrieval and sludge washing, for example, will require copious amounts of sodium hydroxide. If the needed sodium hydroxide could be separated from the waste and recycled, however, the addition of fresh sodium hydroxide could be avoided, ultimately reducing the final waste volume and associated disposal costs. The major objective of this research is to explore new liquid-liquid extraction approaches to the selective separation of sodium hydroxide from alkaline high-level wastes stored in underground tanks at the Hanford and Savannah River sites. Consideration is also given to separating potassium and abundant anions, including nitrate, nitrite, aluminate, and carbonate. Salts of these ions represent possible additional value for recycle, alternative disposal, or even use as commodity chemicals. A comprehensive approach toward understanding the extractive chemistry of these salts is envisioned, involving systems of varying complexity, from use of simple solvents to new bifunctional host molecules for ion-pair recognition. These extractants will ideally require no adjustment of the waste composition and will release the extracted salt into water, thereby consuming no additional chemicals and producing no additional waste volume. The overall goal of this research is to provide a scientific foundation upon which the feasibility of new liquid-liquid extraction chemistry applicable to the bulk reduction of the volume of tank waste can be evaluated

  14. Data summary of municipal solid waste management alternatives. Volume 3, Appendix A: Mass burn technologies

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix on Mass Burn Technologies is the first in a series designed to identify, describe and assess the suitability of several currently or potentially available generic technologies for the management of municipal solid waste (MSW). These appendices, which cover eight core thermoconversion, bioconversion and recycling technologies, reflect public domain information gathered from many sources. Representative sources include: professional journal articles, conference proceedings, selected municipality solid waste management plans and subscription technology data bases. The information presented is intended to serve as background information that will facilitate the preparation of the technoeconomic and life cycle mass, energy and environmental analyses that are being developed for each of the technologies. Mass burn has been and continues to be the predominant technology in Europe for the management of MSW. In the United States, the majority of the existing waste-to-energy projects utilize this technology and nearly 90 percent of all currently planned facilities have selected mass burn systems. Mass burning generally refers to the direct feeding and combustion of municipal solid waste in a furnace without any significant waste preprocessing. The only materials typically removed from the waste stream prior to combustion are large bulky objects and potentially hazardous or undesirable wastes. The technology has evolved over the last 100 or so years from simple incineration to the most highly developed and commercially proven process available for both reducing the volume of MSW and for recovering energy in the forms of steam and electricity. In general, mass burn plants are considered to operate reliably with high availability.

  15. Alternative method for determining the original drop volume of bloodstains on knit fabrics.

    Science.gov (United States)

    Li, Jingyao; Li, Xingyu; Michielsen, Stephen

    2016-06-01

    Bloodstains are often observed at violent crime scenes and on the skin and clothing of persons involved. The diameters of the blood drops that created these stains are related to the force or energy that caused these drops to become airborne. This has resulted in several attempts to determine the diameter of the original drops, beginning with the methods reported in the pioneering work of Henry Lee [6]. However, his methods destroyed the bloodstain during the measurement. Other methods described in the literature cannot be applied to bloodstains on textiles. A new, rapid, reliable, non-destructive method for determining the diameter of the original drop of blood that results in a stain has been developed for bloodstains on cotton single jersey knit (tee-shirt) fabrics, which is one of the most common fabrics analyzed for BPA both at crime scenes and in forensic laboratories. In this method, a drop of known volume of an appropriate artificial blood substitute is applied to a region similar to the stained region but in an area away from any stains/areas of interest. The areas of the original stain and the artificial blood substitute stain are determined, from which the original drop diameter can be calculated. Errors in the drop diameters, the Reynolds numbers and the Weber numbers resulting from this procedure are less than approximately 6%. This procedure has only been verified on cotton single jersey knit fabrics with 30μL≤drop volume≤80μL. It should not be applied to other materials. PMID:27131219

  16. Data summary of municipal solid waste management alternatives. Volume 8, Appendix F, Landfills

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    While the preceding appendices have focused on the thermochemical approaches to managing municipal solid waste (MSW), this appendix and those that follow on composting and anaerobic digestion address more of the bioconversion process technologies. Landfilling is the historical baseline MSW management option central to every community`s solid waste management plan. It generally encompasses shredfills, balefills, landfill gas recovery, and landfill mining. While landfilling is virtually universal in use, it continues to undergo intense scrutiny by the public and regulators alike. Most recently, the US Environmental Protection Agency (EPA) issued its final rule on criteria for designing, operating, monitoring, and closing municipal solid waste landfills. While the Federal government has established nationwide standards and will assist the States in planning and developing their own practices, the States and local governments will carry out the actual planning and direct implementation. The States will also be authorized to devise programs to deal with their specific conditions and needs. While the main body of this appendix and corresponding research was originally prepared in July of 1991, references to the new RCRA Subtitle D, Part 258 EPA regulations have been included in this resubmission (908). By virtue of timing, this appendix is, necessarily, a ``transition`` document, combining basic landfill design and operation information as well as reference to new regulatory requirements. Given the speed with which landfill practices are and will be changing, the reader is encouraged to refer to Part 258 for additional details. As States set additional requirements and schedules and owners and operators of MSW landfills seek to comply, additional guidance and technical information, including case studies, will likely become available in the literature.

  17. Data Summary of Municipal Solid Waste Management Alternatives. Volume VIII: Appendix F - Landfills

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    While the preceding appendices have focused on the thermochemical approaches to managing municipal solid waste (MSW), this appendix and those that follow on composting and anaerobic digestion address more of the bioconversion process technologies. Landfilling is the historical baseline MSW management option central to every community's solid waste management plan. It generally encompasses shredfills, balefills, landfill gas recovery, and landfill mining. While landfilling is virtually universal in use, it continues to undergo intense scrutiny by the public and regulators alike. Most recently, the US Environmental Protection Agency (EPA) issued its final rule on criteria for designing, operating, monitoring, and closing municipal solid waste landfills. While the Federal government has established nationwide standards and will assist the States in planning and developing their own practices, the States and local governments will carry out the actual planning and direct implementation. The States will also be authorized to devise programs to deal with their specific conditions and needs. While the main body of this appendix and corresponding research was originally prepared in July of 1991, references to the new RCRA Subtitle D, Part 258 EPA regulations have been included in this resubmission (908). By virtue of timing, this appendix is, necessarily, a transition'' document, combining basic landfill design and operation information as well as reference to new regulatory requirements. Given the speed with which landfill practices are and will be changing, the reader is encouraged to refer to Part 258 for additional details. As States set additional requirements and schedules and owners and operators of MSW landfills seek to comply, additional guidance and technical information, including case studies, will likely become available in the literature.

  18. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    International Nuclear Information System (INIS)

    Volume 6 of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power-generating capability and one without. This volume also provides estimates of the time required for development of large-scale commercial reactor systems to reach the construction permit application stage and for fuel-cycle facilities to reach the operating license application stage, which is a measure of the relative technical status of alternative nuclear systems

  19. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    International Nuclear Information System (INIS)

    This volume of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power - generating capability and one without

  20. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This volume of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power - generating capability and one without.

  1. Alternative approach to estimate the hydrolysis rate constant of particulate material from batch data

    International Nuclear Information System (INIS)

    Highlights: • An alternative to the commonly used first-order approach is presented. • A relationship between kh and the 1% criterion of the VDI 4630 is deduced. • Equation is proposed to directly calculate kh without the need for data fitting. • Hydrolysis constant kh can then easily be read-off from a table. - Abstract: As anaerobic batch tests are easy to conduct, they are commonly used to assess the effects of different operational factors on the anaerobic digestion process. Hydrolysis of particulate material is often assumed to be the rate limiting step in anaerobic digestion. Its velocity is often estimated by data fitting from batch tests. In this study, a Monod-type alternative to the commonly used first-order approach is presented. The approach was adapted from balancing a continuously stirred-tank reactor and better accommodates the fact that even after a long incubation time, some of the methane potential of the substrate remains untapped in the digestate. In addition, an equation is proposed to directly calculate the hydrolysis constant from the time when the daily gas production is less than 1% of the total gas production. The hydrolysis constant can then easily be read-off from a table when the batch test duration is known

  2. A simple approach for producing colloidal noble metal nanocrystals: Alternating voltage induced electrochemical synthesis

    Science.gov (United States)

    McCann, Kevin

    Intense research has been focused on developing bottom-up nanocrystal synthesis techniques to obtain nanocrystals with sophisticated compositions and enhanced perfomances. Three popular methods are: 1) the reduction of metal complex ions or molecules with selected reducing agents, 2) the decomposition of metal compounds at elevated temperatures, and 3) the electrochemical reduction of metal ions using specialized potentiostats. The first two require expensive metal salt precursors while the last requires specialized potentiostats and either employ a single sacrificial electrode or metal salt precursors. To resolve these issues, we have focused on a facile and generic approach to generate nanocrystals by an alternating voltage induced electrochemical synthesis (AVIES) method. Nanocrystals are produced when an alternating voltage is applied by a common laboratory transformer to two sacrificial electrodes that are inserted in an electrolyte solution containing capping ligands. This work focuses on the ability of the AVIES approach to synthesize Au, Pd, and Pt noble metal nanocrystals. The nanocrystals synthesized were found to be dependent on the electrolyte identity, capping ligand, applied voltage, reaction temperature. The ability of AVIES to produce alloyed nanocrystals starting with alloyed electrodes will be discussed. The AVIES approach requires neither expensive metal compounds nor specialized instruments, is environmentally benign, and can be easily adoptable to any research lab.

  3. A risk management approach to double-shell tank waste volume versus storage capacity

    International Nuclear Information System (INIS)

    A risk-based assessment of the overall waste volume versus double-shell tank storage capacity was conducted to develop fallback positions for projections where the waste volume was at a high risk of exceeding capacity. This study was initiated to provide that assessment. A working simulation model was the primary deliverable of this study. The model validates the approach and demonstrates that simulation analysis can provide a method of tracking uncertainties in available data, assessing probabilities, and serves as a tool to be used by management to determine the consequences of various off-normal occurrences

  4. Hot and Dense Hadron Gas (HG): A New Excluded-volume approach

    CERN Document Server

    Tiwari, S K

    2013-01-01

    We formulate a thermodynamically consistent equation of state (EOS), based on excluded-volume approach, for a hot, dense hadron gas (HG). We calculate various thermodynamical quantities of HG and various hadron ratios and compare our model results with the results of other excluded-volume models and experimental data. We also calculate various transport coefficients such as $\\eta/s$ etc. and compare them with other HG model results. Furthermore, we test the validity of our model in getting the rapidity spectra of various hadrons and the effect of flow on them is investigated by matching our predictions with the experimental data.

  5. An alternative functional renormalization group approach to the single impurity Anderson model

    OpenAIRE

    Kinza, Michael; Ortloff, Jutta; Bauer, Johannes; Honerkamp, Carsten

    2012-01-01

    We present an alternative functional renormalization group (fRG) approach to the single-impurity Anderson model at finite temperatures. Starting with the exact self-energy and interaction vertex of a small system ('core') containing a correlated site, we switch on the hybridization with a non-interacting bath in the fRG-flow and calculate spectra of the correlated site. Different truncations of the RG-flow-equations and choices of the core are compared and discussed. Furthermore we calculate ...

  6. An alternative data filling approach for prediction of missing data in soft sets (ADFIS).

    Science.gov (United States)

    Sadiq Khan, Muhammad; Al-Garadi, Mohammed Ali; Wahab, Ainuddin Wahid Abdul; Herawan, Tutut

    2016-01-01

    Soft set theory is a mathematical approach that provides solution for dealing with uncertain data. As a standard soft set, it can be represented as a Boolean-valued information system, and hence it has been used in hundreds of useful applications. Meanwhile, these applications become worthless if the Boolean information system contains missing data due to error, security or mishandling. Few researches exist that focused on handling partially incomplete soft set and none of them has high accuracy rate in prediction performance of handling missing data. It is shown that the data filling approach for incomplete soft set (DFIS) has the best performance among all previous approaches. However, in reviewing DFIS, accuracy is still its main problem. In this paper, we propose an alternative data filling approach for prediction of missing data in soft sets, namely ADFIS. The novelty of ADFIS is that, unlike the previous approach that used probability, we focus more on reliability of association among parameters in soft set. Experimental results on small, 04 UCI benchmark data and causality workbench lung cancer (LUCAP2) data shows that ADFIS performs better accuracy as compared to DFIS. PMID:27588241

  7. Modern approach to the problem of fossil gas fuels replacement by alternative fuels

    International Nuclear Information System (INIS)

    New scientific and engineering fundamentals of fuels substitution have been developed instead of obsolete methodology “Interchangeability of Fuel Gases” developed in USA and existing from the middle of XXth century. To perform the complex prediction of total or partial substitution of given flow rate of natural gas NG for alternative gases AG the following parameters are to be predicted: plant utilization efficiencies – regarding fuel and energy utilization, the last in form of heat ȘH and exergy Șeff efficiencies, saving or overexpenditure of the NG flow rate in the gas mixture with AG, specific fuel consumption b f and specific issue of harmful substances Ct – pollutants in the combustion products (CNOx ) and greenhouse gases (C CO2 ). Certification of alternative gas fuels and fuel mixtures as a commodity products is carried out in frame of our approach with necessary set of characteristics, similar to those accepted in the world practice. Key words: alternative fuel, fuel replacement (substitution), natural gas, process gases, theoretical combustion temperature, thermodynamic equilibrium computations, total enthalpy

  8. Commentary: The failure of social inclusion: an alternative approach through community development.

    Science.gov (United States)

    Mandiberg, James M

    2012-01-01

    Mental health services have not resulted in broad-based inclusion of people with psychiatric disabilities. Rather, many maintain their community lives only through the support of formal mental health services, which is financially unsustainable given current fiscal realities. Fundamental assumptions about sources of support for everyday life need to be reassessed. The economic and social development of the mental health recovery community provides an alternative approach to helping people maintain successful community lives and shifts some of the supports from mental health providers to business infrastructure within the mental health recovery identity community. Some projects that have utilized this approach, such as business incubators and work integration social enterprises, are described, and community development that builds on concepts of recovery is discussed. PMID:22549533

  9. Interior transmission eigenvalue problem for Maxwell's equations: the T-coercivity as an alternative approach

    International Nuclear Information System (INIS)

    In this paper, we examine the interior transmission problem for Maxwell’s equations in the case where both ε and μ, the physical parameters of the scattering medium, differ from ε0 and μ0 modelling the background medium. Using the T-coercivity method, we propose an alternative approach to the classical techniques to prove that this problem is of Fredholm type and that the so-called transmission eigenvalues form at most a discrete set. The T-coercivity approach allows us to deal with cases where ε − ε0 and μ − μ0 can change sign. We also provide results of localization and Faber–Krahn-type inequalities for the transmission eigenvalues. (paper)

  10. Negative Return-Volume Relationship in Asian Stock Markets: Figarch-Copula Approach

    Directory of Open Access Journals (Sweden)

    Muhammad Naeem

    2014-09-01

    Full Text Available We explore the potential dependence among different Asian stock markets, using several different statistical models. Extreme return-volume dependence in Hong Kong Seng Index, Bombay Stock Exchange, Indonesia Composite Index and Bursa Malaysia has been examined by using FIGARCH-Copula and GARCH-Copula approach. We have used Gaussian, Student-t, Frank, Clayton, Survival Clayton and Gumbel copulas. Based on Akaike information criterion (AIC, we found that using FIGARCH model for return series improves the results of copula parameter estimation. According to our finding, Hong Kong and Indian stock indices showed weak upper tail dependence between return and volume. Further, we have found that the extremely low returns for Malaysia and Indonesia stock indices are followed by high volumes, providing evidence of leverage effect. Our investigation shows that Malaysia and Indonesia stock indices are sensitive to bad news rather than good news.

  11. An alternative approach to reconstructing organic matter accumulation with contrasting watershed disturbance histories from lake sediments

    International Nuclear Information System (INIS)

    A number of proxies, including carbon to nitrogen ratio (C:N) and stable isotopes (δ13C and δ15N), have been used to reconstruct organic matter (OM) profiles from lake sediments and these proxies individually or in combination cannot clearly discriminate different sources. Here we present an alternative approach to elucidate this problem from lake sediments as a function of watershed scale land use changes. Stable isotope signatures of defined OM sources from the study watersheds, Shawnigan Lake (SHL) and Elk Lake (ELL), were compared with sedimentary proxy records. Results from this study reveal that terrestrial inputs and catchment soil coinciding with the watershed disturbances histories probably contributed in recent trophic enrichment in SHL. In contrast, cultural eutrophication in ELL was partially a result of input from catchment soil (agricultural activities) with significant input from lake primary production as well. Results were consistent in both IsoSource (IsoSource version 1.2 is a Visual Basic program used for source separation, ( (http://www.epa.gov/wed/pages/models/isosource/isosource.htm)) and discriminant analysis (statistical classification technique). - The study shows an alternative approach to reconstruct organic matter accumulation using stable isotopes from lake sediments

  12. EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2015)

    OpenAIRE

    ZUANG Valerie; DESPREZ BERTRAND; VIEGAS BARROSO JOAO FILIPE; BELZ SUSANNE; BERGGREN ELISABET; Bernasconi, Camilla; BESSEMS JOSEPH; BOPP Stephanie; CASATI Silvia; Coecke, Sandra; Corvi, Raffaella; DUMONT CORALIE; GOULIARMOU VARVARA; GRIESINGER Claudius; HALDER MARIA ELISABETH

    2015-01-01

    The EURL ECVAM status report provides an update on the progress made in the development, validation and regulatory acceptance of alternative methods and approaches and their dissemination since the last report published in June 2014. It is informing on ongoing research and development activities, validation studies, peer reviews, recommendations, strategies and regulatory/international acceptance of alternative methods and approaches and dissemination activities. R&D activities within l...

  13. Negative Return-Volume Relationship in Asian Stock Markets: Figarch-Copula Approach

    OpenAIRE

    Muhammad Naeem; Hao Ji; Brunero Liseo

    2014-01-01

    We explore the potential dependence among different Asian stock markets, using several different statistical models. Extreme return-volume dependence in Hong Kong Seng Index, Bombay Stock Exchange, Indonesia Composite Index and Bursa Malaysia has been examined by using FIGARCH-Copula and GARCH-Copula approach. We have used Gaussian, Student-t, Frank, Clayton, Survival Clayton and Gumbel copulas. Based on Akaike information criterion (AIC), we found that using FIGARCH model for ...

  14. A proposed alternative approach for protection of inadvertent human intruders from buried Department of Energy low level radioactive wastes

    International Nuclear Information System (INIS)

    The burial of radioactive wastes creates a legacy. To limit the impact of this legacy on future generations, we establish and comply with performance objectives. This paper reviews performance objectives for the long-term isolation of buried radioactive wastes; identifies regulatorly-defined performance objectives for protecting the inadvertent human intruder (IHI) from buried low-level radioactive waste (LLW); (3) discusses a shortcoming of the current approach; and (4) offers an alternative approach for protecting the IHI. This alternative approach is written specifically for the burial of US Department of Energy (DOE) wastes at the Nevada Test Site (NTS), although the approach might be applied at other DOE burial sites

  15. "Ultra-rapid" sequential treatment in cholecystocholedocholithiasis: alternative same-day approach to laparoendoscopic rendezvous.

    Science.gov (United States)

    Borreca, Dario; Bona, Alberto; Bellomo, Maria Paola; Borasi, Andrea; De Paolis, Paolo

    2015-12-01

    There is still no consensus about timing of laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreatography in the treatment of cholecystocholedocholithiasis. The aim of our retrospective study is to analyze the optimal timing of surgical treatment in patients presenting concurrent choledocholithiasis, choosing to perform a sequential endoscopic plus surgical approach, introducing a same-day two-stage alternative. All cases of cholecystocholedocholithiasis occurred between January 2007 and December 2014 in "Gradenigo" Hospital (Turin-Italy) were reviewed. Patients were divided into three groups, based on the timing of cholecystectomy after endoscopic retrograde cholangiopancreatography, and compared. Out of 2233 cholecystectomies performed in the mentioned time interval, have been identified 93 patients that fulfill the selection criteria. 36 patients were treated with a same-day approach, while 29 within first 72 h and 28 with delayed surgery. The overall length of stay was significantly lower in patients that were treated with a same-day approach (4.7 days), compared with other groups (p = 0.001), while no significant differences were found in terms of length of surgical intervention, intraoperative complications and conversions to open procedure, postoperative stay, morbidity and mortality. Patients treated with delayed surgery had a 18 % recurrency rate of biliary events, with an odds ratio of 14.13 (p = 0.018). Same-day two-stage approach should be performed in suitable patients at the index admission, reducing overall risks, improving the patients' quality-of-life, preventing recurrency, leading to a significant cost abatement; furthermore, this approach allows same outcomes of laparoendoscopic rendezvous, avoiding technical and organizational troubles. PMID:26659267

  16. Understanding anorexia: an hermeneutic approach as a methodological alternative for the field of contemporary anorexia research

    Directory of Open Access Journals (Sweden)

    Anne Puuronen

    1999-01-01

    Full Text Available Theories of anorexia nervosa have mainly been dominated by psychiatry and concentrate upon its physiological aspects, both in diagnosis and treatment. This has led to a search for organic causes behind anorectic conditions, instead of seeing it as molded and shaped both by the individual and the socio-cultural context. This "medicalisation" has been an impediment to a more complete conceptualisation of the experience of discipline and of the ascetic modes of action in anorexia. The intension is to approach anorexia as lived process. The focus is not in explaining what cause anorexia, but is centered on the contents of living experience as such. Thus, the author proposes a phenomenological approach to anorexia as a methodological alternative compared to the dominant medico-psychological approaches to anorexia of today. If we consider the body of an anorectic person as an intersection in which the subject's relationship to social reality will be materialized and verified, we are able to see first how accurate a picture of the dual meanings, double bindings and paradoxical commitments of our present culture and its relation to a woman's body anorexia will draw up. Also, because the fact is that anorexia is a predominantly "women's" illness we have to take in account that the construction of subjectivity and in this context the construction of a lived anorectic experience of discipline, is not a gender-neutral process.

  17. Alternative approaches for better municipal solid waste management in Mumbai, India

    International Nuclear Information System (INIS)

    Waste is an unavoidable by product of human activities. Economic development, urbanization and improving living standards in cities, have led to an increase in the quantity and complexity of generated waste. Rapid growth of population and industrialization degrades the urban environment and places serious stress on natural resources, which undermines equitable and sustainable development. Inefficient management and disposal of solid waste is an obvious cause of degradation of the environment in most cities of the developing world. Municipal corporations of the developing countries are not able to handle increasing quantities of waste, which results in uncollected waste on roads and in other public places. There is a need to work towards a sustainable waste management system, which requires environmental, institutional, financial, economic and social sustainability. This study explores alternative approaches to municipal solid waste (MSW) management and estimates the cost of waste management in Mumbai, India. Two alternatives considered in the paper are community participation and public private partnership in waste management. Data for the present study are from various non-governmental organizations (NGOs) and from the private sector involved in waste management in Mumbai. Mathematical models are used to estimate the cost per ton of waste management for both of the alternatives, which are compared with the cost of waste management by Municipal Corporation of Greater Mumbai (MCGM). It is found that the cost per ton of waste management is Rs. 1518 (US$35) with community participation; Rs. 1797 (US$41) with public private partnership (PPP); and Rs. 1908 (US$44) when only MCGM handles the waste. Hence, community participation in waste management is the least cost option and there is a strong case for comprehensively involving community participation in waste management

  18. Anterior sagittal anorectoplasty: An alternative to posterior approach in management of congenital vestibular fistula

    Directory of Open Access Journals (Sweden)

    Man Mohan Harjai

    2013-01-01

    Full Text Available Background: Better exposure, possibility of extension if needed and precise placement of the anal canal within the external sphincter complex have made the posterior and anterior sagittal approaches more popular and established for the correction of anovestibular fistula. The mini posterior sagittal anorectoplasty (PSARP was the procedure of choice for female ARM at our center till date. As an alternative surgical option, we performed anterior sagittal anorectoplasty (ASARP in 15 cases of anovestibular fistula and compared them with 12 cases of vestibular fistula operated by PSARP technique. Patients and Methods: Fifteen female infants with vestibular fistula who had anterior sagittal anorectoplasty (ASARP procedure were reviewed. The procedure and its outcome were evaluated. Results : The manoeuvering during anesthesia and operative access were quite easier in ASARP compared to PSARP. Delineation of plane in ASARP between rectum and vagina was easier and clearer in comparison to PSARP. Rent occurred in the posterior vaginal wall in three cases of ASARP and two cases of PSARP. There were two cases of wound infection in each group. Three cases of PSARP group developed anal stenosis and constipation while one in the ASARP group developed constipation. Conclusion : Anesthesia and access in ASARP makes it an easier alternative option to PSARP in the management of anovestibular fistula in girls.

  19. An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes.

    Science.gov (United States)

    Gissi, Andrea; Gadaleta, Domenico; Floris, Matteo; Olla, Stefania; Carotti, Angelo; Novellino, Ettore; Benfenati, Emilio; Nicolotti, Orazio

    2014-01-01

    The REACH (Registration, Evaluation, Authorization and restriction of Chemicals) and BPR (Biocide Product Regulation) regulations strongly promote the use of non-animal testing techniques to evaluate chemical risk. This has renewed the interest towards alternative methods such as QSAR in the regulatory context. The assessment of Bioconcentration Factor (BCF) required by these regulations is expensive, in terms of costs, time, and laboratory animal sacrifices. Herein, we present QSAR models based on the ANTARES dataset, which is a large collection of known and verified experimental BCF data. Among the models developed, the best results were obtained from a nine-descriptor highly predictive model. This model was derived from a training set of 608 chemicals and challenged against a validation and blind set containing 152 and 76 chemicals. The model's robustness was further controlled through several validation strategies and the implementation of a multi-step approach for the applicability domain. Suitable safety margins were used to increase sensitivity. The easy interpretability of the model is ensured by the use of meaningful biokinetics descriptors. The satisfactory predictive power for external compounds suggests that the new models could represent a reliable alternative to the in vivo assay, helping the registrants to fulfill regulatory requirements in compliance with the ethical and economic necessity to reduce animal testing. PMID:24247988

  20. Management of spent oxide fuel from thermal reactors: the environmental and radiological effects of alternative approaches

    International Nuclear Information System (INIS)

    The report presents the results of a study of the environmental and radiological effects of alternative approaches to the management of spent oxide fuel from the UK nuclear power programme. The two main alternatives are extended storage of the fuel, pending decisions on fissile material recycle, and reprocessing of the fuel commencing in the early 1990s. A review is made of experience in spent fuel storage, of the technical issues in long-term storage and of the possible needs of the UK nuclear programme. The main environmental and radiological effects of reprocessing considered in the study are the generation of radioactive wastes, the release of radioactivity in effluents with the resulting radiation exposure of the public, and occupational radiation exposure. The influence of the delay between reprocessing and fabrication of mixed oxide fuel on the environmental and radiological effects of plutonium recycle is investigated and it is shown that the effects would be minimised if reprocessing were delayed until there was a requirement for recycle. Strategies for the management of heavy elements other than plutonium are discussed and results are presented illustrating aspects of actinide management. (author)

  1. Management of Crohn's disease in smokers: Is an alternative approach necessary?

    Institute of Scientific and Technical Information of China (English)

    Pilar Nos; Eugeni Domènech

    2011-01-01

    Inflammatory bowel disease (IBD) is a chronic condition with a pathogenic background that involves both genetic and environmental factors. Although important progress has been made regarding the former in the last decade, scarce knowledge is available for the latter. In this sense, smoking remains the most important environmental factor in IBD. Active smoking increases the risk of developing Crohn's disease (CD). Moreover, CD patients who start or continue smoking after disease diagnosis are at risk for poorer outcomes such as higher therapeutic requirements and disease-related complications, as compared to those patients who quit smoking or who never smoked. However, the harmful effect of active smoking is not uniform in all patients or in all clinical scenarios. Interventions designed to facilitate smoking cessation may impact the course of the disease. In this article, the available evidence of the deleterious effects of smoking on CD is reviewed in detail, and alternative therapeutic approaches to CD in smokers are proposed.

  2. Alternative sources of power generation, incentives and regulatory mandates: a theoretical approach to the Colombian case

    International Nuclear Information System (INIS)

    Alternative Energy Generation Sources are turning relevant in several countries worldwide because of technology improvement and the environmental treatment. In this paper, the most common problems of renewable energy sources are accomplished, different incentives and regulatory mandates from several countries are exposed, and a first theoretical approach to a renewable energies incentive system in Colombia is discussed. The paper is fundamentally in theoretical aspects and international experience in renewable energies incentives to accelerate their diffusion; features are analyzed towards a special incentive system for renewable energies in Colombia. As a conclusion, in Colombia will be apply indirect incentives like low interest rate, taxes exemptions and so on. But these incentives are applied to limit the support of electricity productivity in generating organizations.

  3. Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report.

    Science.gov (United States)

    Karanth, Hamsaraj; Shenoy, Vikram Subraya; Murthy, Rayasa Ramachandra

    2006-01-01

    The purpose of this report was to compile relevant technical information on various alternative strategies that can be used as feasible approaches in the development of solid dispersions. The technologies discussed in the report are spray coating on sugar beads with a fluidized bed coating system, hot melt extrusion, direct capsule filling, electrostatic spinning, surface active carriers, and supercritical fluid technology. The focus is on basic principles, the equipment involved, and the relevant scale-up work. These technologies have been found to eliminate several drawbacks posed by the conventional methods of manufacturing of solid dispersions such as laborious preparation methods, reproducibility, scaling up of manufacturing processes, stability of drug, and vehicle. PMID:17233539

  4. An alternate approach to calibrating FAC-predictive models using inspection data (Log Book No. 398)

    International Nuclear Information System (INIS)

    Flow-Accelerated Corrosion (FAC) of piping and fittings in Nuclear Energy Plants can pose a threat to personnel safety, reduce plant availability, and result in undesirable challenges to plant safety systems. For these reasons, accurate predictions of FAC-induced wear rates are extremely valuable in that they allow action to be taken prior to component failure. The EPRI recommended method of predicting FAC wear rates for inspected as well as uninspected components allows for calibration of predictions through the use of wall thickness measurements obtained from UT inspections. This method uses a simple linear correction based on the median value of the ratio of measured to predicted thickness. An alternate approach is presented that takes local thermodynamic variations into account, thus resulting in an improved correlation with measured data. (author)

  5. Up-Rating - An Alternative Approach to Meeting Future Power Demands - Exploitation of Design Margins

    International Nuclear Information System (INIS)

    Up-rating is a world-wide implemented approach that takes advantage of increased calculation and analytic abilities developed since commissioning and applies them to old plants. In doing so, what would possibly be considered today as over-engineered design margins are exploited and plant performance is improved, without necessarily involving extensive modifications or replacement of hardware. It is therefore a short-term alternative, compared to new plants, with little change in environmental ramifications for power production capacity gained. Up-rating is also more accepted by the wider community and licensing authorities, thus complimenting the building of new plants. The 10% thermal up-rating of the nuclear power plant at Almaraz, Spain, requires a comprehensive reanalysis of all power components. This paper focuses on those measures required to ensure the performance of the steam generators at increased load as an example of design margin exploitation in such crucial components. (authors)

  6. An Alternative Approach to Control Measurements of Crane Rails

    Directory of Open Access Journals (Sweden)

    Dušan Kogoj

    2012-05-01

    Full Text Available Horizontal and vertical positions of points for the control assessment of crane rails are classically determined separately. The procedure is time consuming and causes non-homogenous accuracy of the horizontal and vertical position of control points. The proposed alternative approach is based on polar measurements using a high accuracy total station instrument and a special platform with two precise surveying prisms fixed on it. Measurements are carried out from a single station thus ensuring a common coordinate system and homogenous accuracy. The position of the characteristic point of a rail is derived from the measured positions of both prisms with known geometry of the platform. The influence of platform non-horizontality is defined, along with its elimination procedure. Accuracy assessment is ensured with redundant measurements. Result of the proposed procedure is a numerical and graphical presentation of characteristic points. The control parameters required in international Eurocode standards are easily determined from them.

  7. An Alternative Dimension Reduction Approach to Supervised Principal Components Analysis in High Dimensional Survival Data

    Directory of Open Access Journals (Sweden)

    Elvan AKTURK HAYAT

    2016-04-01

    Full Text Available Objective: This study aims at comparing the performances of supervised principal component analysis (SPCA which is used for dimension reduction and an alternatively proposed approach of nonlinear principal component analysis using artificial neural networks performed by gene selection with survival tree (survival tree based NLPCA- NN. Material and Methods: Gene expression data set from Rosenwald et al.(2002 pertaining to 240 patients with diffuse large B-cell lymphoma (DLBCL is used. While Cox scores are used for determining important genes from high dimensional gene expression data in SPCA, in survival tree based NLPCA-NN approach, importance values of the survival tree are used. Important genes according to the Cox scores are reduced to three principal components by singular value decomposition. Important genes determined by the survival tree are taken as input variables in neural networks and reduced to three principal components. The performances of SPCA and survival tree based NLPCA-NN are compared by using Cox regression models (CRM. C index is calculated to compare obtained Cox regression models. Results: According to Cox scores, 121 genes are determined; according to importance values of survival tree 114 genes are determined. The percentages of variances explained by SPCA and survival tree based NLPCA-NN were 18.2% and 35.1% respectively. Harrell?s C indexes are calculated as 0.726 for CRM-1, 0.687 for CRM-2. Conclusion: As a result, while SPCA takes only the linear relationships into consideration, survival tree based NLPCA-NN also takes non-linear relationships into account and has more variance explanation and NLPCA-NN can be evaluated as an alternative method to SPCA.

  8. A Cost Comparison of Alternative Approaches to Distance Education in Developing Countries

    Science.gov (United States)

    Ventre, Gerard G.; Kalu, Alex

    1996-01-01

    This paper presents a cost comparison of three approaches to two-way interactive distance learning systems for developing countries. Included are costs for distance learning hardware, terrestrial and satellite communication links, and designing instruction for two-way interactive courses. As part of this project, FSEC is developing a 30-hour course in photovoltaic system design that will be used in a variety of experiments using the Advanced Communications Technology Satellite (ACTS). A primary goal of the project is to develop an instructional design and delivery model that can be used for other education and training programs. Over two-thirds of the world photovoltaics market is in developing countries. One of the objectives of this NASA-sponsored project was to develop new and better energy education programs that take advantage of advances in telecommunications and computer technology. The combination of desktop video systems and the sharing of computer applications software is of special interest. Research is being performed to evaluate the effectiveness of some of these technologies as part of this project. The design of the distance learning origination and receive sites discussed in this paper were influenced by the educational community's growing interest in distance education. The following approach was used to develop comparative costs for delivering interactive distance education to developing countries: (1) Representative target locations for receive sites were chosen. The originating site was assumed to be Cocoa, Florida, where FSEC is located; (2) A range of course development costs were determined; (3) The cost of equipment for three alternative two-way interactive distance learning system configurations was determined or estimated. The types of system configurations ranged from a PC-based system that allows instructors to originate instruction from their office using desktop video and shared application software, to a high cost system that uses a

  9. Challenges and implications of global modeling approaches that are alternatives to using constant plant functional types

    Science.gov (United States)

    Bodegom, P. V.

    2015-12-01

    In recent years a number of approaches have been developed to provide alternatives to the use of plant functional types (PFTs) with constant vegetation characteristics for simulating vegetation responses to climate changes. In this presentation, an overview of those approaches and their challenges is given. Some new approaches aim at removing PFTs altogether by determining the combination of vegetation characteristics that would fit local conditions best. Others describe the variation in traits within PFTs as a function of environmental drivers, based on community assembly principles. In the first approach, after an equilibrium has been established, vegetation composition and its functional attributes can change by allowing the emergence of a new type that is more fit. In the latter case, changes in vegetation attributes in space and time as assumed to be the result intraspecific variation, genetic adaptation and species turnover, without quantifying their respective importance. Hence, it is assumed that -by whatever mechanism- the community as a whole responds without major time lags to changes in environmental drivers. Recently, we showed that intraspecific variation is highly species- and trait-specific and that none of the current hypotheses on drivers of this variation seems to hold. Also genetic adaptation varies considerably among species and it is uncertain whether it will be fast enough to cope with climate change. Species turnover within a community is especially fast in herbaceous communities, but much slower in forest communities. Hence, it seems that assumptions made may not hold for forested ecosystems, but solutions to deal with this do not yet exist. Even despite the fact that responsiveness of vegetation to environmental change may be overestimated, we showed that -upon implementation of trait-environment relationships- major changes in global vegetation distribution are projected, to similar extents as to those without such responsiveness.

  10. Bronchoscopic lung volume reduction

    Directory of Open Access Journals (Sweden)

    M. I. Polkey

    2006-12-01

    Full Text Available Surgical lung volume reduction can improve exercise performance and forced expiratory volume in one second in patients with emphysema. However, the procedure is associated with a 5% mortality rate and a nonresponse rate of 25%. Accordingly, interest has focused on alternative ways of reducing lung volume. Two principle approaches are used: collapse of the diseased area using blockers placed endobronchially and the creation of extrapulmonary pathways. Preliminary data from the former approach suggest that it can be successful and that the magnitude of success is related to reduction in dynamic hyperinflation.

  11. An Electric Field Volume Integral Equation Approach to Simulate Surface Plasmon Polaritons

    Directory of Open Access Journals (Sweden)

    Rob Remis

    2013-02-01

    Full Text Available In this paper we present an electric field volume integral equation approach to simulate surface plasmon propagation along metal/dielectric interfaces. Metallic objects embedded in homogeneous dielectric media are considered. Starting point is a so-called weak-form of the electric field integral equation. This form is discretized on a uniform tensor-product grid resulting in a system matrix whose action on a vector can be computed via the fast Fourier transform. The GMRES iterative solver is used to solve the discretized set of equations and numerical examples, illustrating surface plasmon propagation, are presented. The convergence rate of GMRES is discussed in terms of the spectrum of the system matrix and through numerical experiments we show how the eigenvalues of the discretized volume scattering operator are related to plasmon propagation and the medium parameters of a metallic object.

  12. Total soil DNA quantification as an alternative microbial biomass determination approach

    Science.gov (United States)

    Semenov, Mikhail

    2015-04-01

    .87 indicated slight (about 13%) underestimation of microbial biomass-C obtained by the CFE approach. Thus, quantification of microbial dsDNA is an alternative option to determine soil microbial biomass under extreme conditions, e.g., in frozen and alkaline soils. In contrast to approaches based on indirect characteristics (respiration, etc.), the DNA-based approach enables evaluating microbial biomass using the immediate content of basic cell compounds universal to all living organisms. This research was supported by the Russian Science Foundation, Project No 14-14-00625.

  13. Alternate approaches to verifying the structural adequacy of the Defense High Level Waste Shipping Cask

    Energy Technology Data Exchange (ETDEWEB)

    Zimmer, A.; Koploy, M.

    1991-12-01

    In the early 1980s, the US Department of Energy/Defense Programs (DOE/DP) initiated a project to develop a safe and efficient transportation system for defense high level waste (DHLW). A long-standing objective of the DHLW transportation project is to develop a truck cask that represents the leading edge of cask technology as well as one that fully complies with all applicable DOE, Nuclear Regulatory Commission (NRC), and Department of Transportation (DOT) regulations. General Atomics (GA) designed the DHLW Truck Shipping Cask using state-of-the-art analytical techniques verified by model testing performed by Sandia National Laboratories (SNL). The analytical techniques include two approaches, inelastic analysis and elastic analysis. This topical report presents the results of the two analytical approaches and the model testing results. The purpose of this work is to show that there are two viable analytical alternatives to verify the structural adequacy of a Type B package and to obtain an NRC license. It addition, this data will help to support the future acceptance by the NRC of inelastic analysis as a tool in packaging design and licensing.

  14. An Alternative Methodological Approach for Cost-Effectiveness Analysis and Decision Making in Genomic Medicine.

    Science.gov (United States)

    Fragoulakis, Vasilios; Mitropoulou, Christina; van Schaik, Ron H; Maniadakis, Nikolaos; Patrinos, George P

    2016-05-01

    Genomic Medicine aims to improve therapeutic interventions and diagnostics, the quality of life of patients, but also to rationalize healthcare costs. To reach this goal, careful assessment and identification of evidence gaps for public health genomics priorities are required so that a more efficient healthcare environment is created. Here, we propose a public health genomics-driven approach to adjust the classical healthcare decision making process with an alternative methodological approach of cost-effectiveness analysis, which is particularly helpful for genomic medicine interventions. By combining classical cost-effectiveness analysis with budget constraints, social preferences, and patient ethics, we demonstrate the application of this model, the Genome Economics Model (GEM), based on a previously reported genome-guided intervention from a developing country environment. The model and the attendant rationale provide a practical guide by which all major healthcare stakeholders could ensure the sustainability of funding for genome-guided interventions, their adoption and coverage by health insurance funds, and prioritization of Genomic Medicine research, development, and innovation, given the restriction of budgets, particularly in developing countries and low-income healthcare settings in developed countries. The implications of the GEM for the policy makers interested in Genomic Medicine and new health technology and innovation assessment are also discussed. PMID:27096406

  15. Alternative approach to precision narrow-angle astrometry for Antarctic long baseline interferometry

    CERN Document Server

    Kok, Y; Rizzuto, A C; Tuthill, P G; Robertson, J G; Warrington, B A; Tango, W J

    2014-01-01

    The conventional approach to high-precision narrow-angle astrometry using a long baseline interferometer is to directly measure the fringe packet separation of a target and a nearby reference star. This is done by means of a technique known as phase-referencing which requires a network of dual beam combiners and laser metrology systems. Using an alternative approach that does not rely on phase-referencing, the narrow-angle astrometry of several closed binary stars (with separation less than 2$"$), as described in this paper, was carried out by observing the fringe packet crossing event of the binary systems. Such an event occurs twice every sidereal day when the line joining the two stars of the binary is is perpendicular to the projected baseline of the interferometer. Observation of these events is well suited for an interferometer in Antarctica. Proof of concept observations were carried out at the Sydney University Stellar Interferometer (SUSI) with targets selected according to its geographical location....

  16. Alternate approaches to verifying the structural adequacy of the Defense High Level Waste Shipping Cask

    International Nuclear Information System (INIS)

    In the early 1980s, the US Department of Energy/Defense Programs (DOE/DP) initiated a project to develop a safe and efficient transportation system for defense high level waste (DHLW). A long-standing objective of the DHLW transportation project is to develop a truck cask that represents the leading edge of cask technology as well as one that fully complies with all applicable DOE, Nuclear Regulatory Commission (NRC), and Department of Transportation (DOT) regulations. General Atomics (GA) designed the DHLW Truck Shipping Cask using state-of-the-art analytical techniques verified by model testing performed by Sandia National Laboratories (SNL). The analytical techniques include two approaches, inelastic analysis and elastic analysis. This topical report presents the results of the two analytical approaches and the model testing results. The purpose of this work is to show that there are two viable analytical alternatives to verify the structural adequacy of a Type B package and to obtain an NRC license. It addition, this data will help to support the future acceptance by the NRC of inelastic analysis as a tool in packaging design and licensing

  17. Comparison of marine spatial planning methods in Madagascar demonstrates value of alternative approaches.

    Directory of Open Access Journals (Sweden)

    Thomas F Allnutt

    Full Text Available The Government of Madagascar plans to increase marine protected area coverage by over one million hectares. To assist this process, we compare four methods for marine spatial planning of Madagascar's west coast. Input data for each method was drawn from the same variables: fishing pressure, exposure to climate change, and biodiversity (habitats, species distributions, biological richness, and biodiversity value. The first method compares visual color classifications of primary variables, the second uses binary combinations of these variables to produce a categorical classification of management actions, the third is a target-based optimization using Marxan, and the fourth is conservation ranking with Zonation. We present results from each method, and compare the latter three approaches for spatial coverage, biodiversity representation, fishing cost and persistence probability. All results included large areas in the north, central, and southern parts of western Madagascar. Achieving 30% representation targets with Marxan required twice the fish catch loss than the categorical method. The categorical classification and Zonation do not consider targets for conservation features. However, when we reduced Marxan targets to 16.3%, matching the representation level of the "strict protection" class of the categorical result, the methods show similar catch losses. The management category portfolio has complete coverage, and presents several management recommendations including strict protection. Zonation produces rapid conservation rankings across large, diverse datasets. Marxan is useful for identifying strict protected areas that meet representation targets, and minimize exposure probabilities for conservation features at low economic cost. We show that methods based on Zonation and a simple combination of variables can produce results comparable to Marxan for species representation and catch losses, demonstrating the value of comparing alternative

  18. Associative memory in a volume holographic medium: a new approach based on operator theory

    International Nuclear Information System (INIS)

    In this article, we present a new method for holographic implementation of associative memories. In the current approach, the memory capacity is implemented in the form of spatial perturbation of refractive index within the volume of a three dimensional holographic material. We use operator theory to solve the inverse problem and compute a closed-form solution for the spatial distribution of the perturbation considering any arbitrary set of input–output prototype vectors. Simplicity of the hardware is the major advantage of the current method. (papers)

  19. Associative memory in a volume holographic medium: a new approach based on operator theory

    Science.gov (United States)

    Pashaie, Ramin

    2014-07-01

    In this article, we present a new method for holographic implementation of associative memories. In the current approach, the memory capacity is implemented in the form of spatial perturbation of refractive index within the volume of a three dimensional holographic material. We use operator theory to solve the inverse problem and compute a closed-form solution for the spatial distribution of the perturbation considering any arbitrary set of input-output prototype vectors. Simplicity of the hardware is the major advantage of the current method.

  20. Extension of the direct statistical approach to a volume parameter model (non-integer splitting)

    International Nuclear Information System (INIS)

    The Direct Statistical Approach is a rigorous mathematical derivation of the second moment for surface splitting and Russian Roulette games attached to the Monte Carlo modelling of fixed source particle transport. It has been extended to a volume parameter model (involving non-integer ''expected value'' splitting), and then to a cell model. The cell model gives second moment and time functions that have a closed form. This suggests the possibility of two different methods of solution of the optimum splitting/Russian Roulette parameters. (author)

  1. The West Central Alberta Woodland Caribou Landscape Plan: Using a Modeling Approach to Develop Alternative Scenarios

    Directory of Open Access Journals (Sweden)

    Anne Hubbs

    2011-09-01

    Full Text Available Woodland caribou (Rangifer tarandus are classified as threatened in Alberta. In support of Canada's Species at Risk Act, a Recovery Plan for Woodland Caribou in Alberta was completed in 2004 which required local implementation plans to be completed within 5 areas of the province. The West Central Alberta Caribou Landscape Plan (WCCLP is the first of these to be initiated and it addresses the recovery strategies for 4 herds. Two aspatial computer models built on the STELLA© modelling platform (ISee Systems, 2007 were used to assist the planning team in evaluating cumulative effects and alternative scenarios for caribou conservation. The ALCES© (Forem Technologies 2008 modelling tool was used to forecast potential changes in the west central Alberta landscape over time. Yearly landscape condition outputs from ALCES© were then exported into a caribou-specific population model, REMUS© (Weclaw, 2004, that was used to project potential population responses by woodland caribou, other primary prey species [moose (Alces alces, elk (Cervus elaphus and deer (Odocoileus sp.] and wolves (Canis lupus (Weclaw & Hudson, 2004. Simulated habitat management strategies that resulted in the highest likelihood of caribou recovery included the maintenance of a high proportion of old forest, the aggregation of industrial footprints and the reclamation of historic seismic lines (although the latter took decades to provide real dividends. Sharing of industrial roads, protection of fragments of old-growth, and expanding an already aggressive fire control strategy in Alberta had little additional effect on caribou recovery. Simulated population management strategies that were successful all involved decades of intensive wolf control, either directly or indirectly through intensive primary prey control (with the exception of woodland caribou until old-growth forests recovered to densities that provided caribou habitat and decreased alternate prey of wolves. Although

  2. Promoting functional foods as acceptable alternatives to doping: potential for information-based social marketing approach

    Directory of Open Access Journals (Sweden)

    Petróczi Andrea

    2010-11-01

    Full Text Available Abstract Background Substances with performance enhancing properties appear on a continuum, ranging from prohibited performance enhancing drugs (PED through dietary supplements to functional foods (FF. Anti-doping messages designed to dissuade athletes from using PEDs have been typically based on moralising sport competition and/or employing scare campaigns with focus on the negative consequences. Campaigns offering comparable and acceptable alternatives are nonexistent, nor are athletes helped in finding these for themselves. It is timely that social marketing strategies for anti-doping prevention and intervention incorporate media messages that complement the existing approaches by promoting comparable and acceptable alternatives to doping. To facilitate this process, the aim of this study was to ascertain whether a single exposure knowledge-based information intervention led to increased knowledge and subsequently result in changes in beliefs and automatic associations regarding performance enhancements. Methods In a repeated measure design, 115 male recreational gym users were recruited and provided with a brief information pamphlet on nitrite/nitrate and erythropoietin as a comparison. Measures of knowledge, beliefs and automatic associations were taken before and after the intervention with at least 24 hours between the two assessments. The psychological tests included explicit measures of beliefs and cognitive attitudes toward FF and PED using a self-reported questionnaire and computerised assessments of automatic associations using the modified and shortened version of the Implicit Association Test. Results The information based intervention significantly increased knowledge (p p p Conclusion Evidence was found that even a single exposure to a persuasive positive message can lead to belief change and can create new or alter existing associations - but only in the specific domain. Interventions to change outcome expectations in a positive

  3. Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

    Directory of Open Access Journals (Sweden)

    Mirza MU

    2015-03-01

    Full Text Available Muhammad Usman Mirza,1 Noor-Ul-Huda Ghori,2 Nazia Ikram,3 Abdur Rehman Adil,4 Sadia Manzoor3 1Centre for Research in Molecular Medicine (CRiMM, The University of Lahore, Lahore, 2Atta-ur-Rehman School of Applied Biosciences (ASAB, National University of Science and Technology, Islamabad, 3Institute of Molecular Biology and Biotechnology (IMBB, The University of Lahore, Lahore, Pakistan; 4Centre for Excellence in Molecular Biology (CEMB, The University of Punjab, Lahore, Pakistan Abstract: Hepatitis C virus (HCV is one of the major viruses affecting the world today. It is a highly variable virus, having a rapid reproduction and evolution rate. The variability of genomes is due to hasty replication catalyzed by nonstructural protein 5B (NS5B which is also a potential target site for the development of anti-HCV agents. Recently, the US Food and Drug Administration approved sofosbuvir as a novel oral NS5B inhibitor for the treatment of HCV. Unfortunately, it is much highlighted for its pricing issues. Hence, there is an urgent need to scrutinize alternate therapies against HCV that are available at affordable price and do not have associated side effects. Such a need is crucial especially in underdeveloped countries. The search for various new bioactive compounds from plants is a key part of pharmaceutical research. In the current study, we applied a pharmacoinformatics-based approach for the identification of active plant-derived compounds against NS5B. The results were compared to docking results of sofosbuvir. The lead compounds with high-binding ligands were further analyzed for pharmacokinetic and pharmacodynamic parameters based on in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET profile. The results showed the potential alternative lead compounds that can be developed into commercial drugs having high binding energy and promising ADMET properties. Keywords: hepatitis C, NS5B inhibitors, molecular docking, Auto

  4. Shifting Away From Fee-For-Service: Alternative Approaches to Payment in Gastroenterology.

    Science.gov (United States)

    Patel, Kavita; Presser, Elise; George, Meaghan; McClellan, Mark

    2016-04-01

    Fee-for-service payments encourage high-volume services rather than high-quality care. Alternative payment models (APMs) aim to realign financing to support high-value services. The 2 main components of gastroenterologic care, procedures and chronic care management, call for a range of APMs. The first step for gastroenterologists is to identify the most important conditions and opportunities to improve care and reduce waste that do not require financial support. We describe examples of delivery reforms and emerging APMs to accomplish these care improvements. A bundled payment for an episode of care, in which a provider is given a lump sum payment to cover the cost of services provided during the defined episode, can support better care for a discrete procedure such as a colonoscopy. Improved management of chronic conditions can be supported through a per-member, per-month (PMPM) payment to offer extended services and care coordination. For complex chronic conditions such as inflammatory bowel disease, in which the gastroenterologist is the principal care coordinator, the PMPM payment could be given to a gastroenterology medical home. For conditions in which the gastroenterologist acts primarily as a consultant for primary care, such as noncomplex gastroesophageal reflux or hepatitis C, a PMPM payment can support effective care coordination in a medical neighborhood delivery model. Each APM can be supplemented with a shared savings component. Gastroenterologists must engage with and be early leaders of these redesign discussions to be prepared for a time when APMs may be more prevalent and no longer voluntary. PMID:26122765

  5. A Novel Approach to Measure the Volume Change of Triaxial Soil Samples Based on Image Processing

    Directory of Open Access Journals (Sweden)

    A.R. Bagherieh

    2008-01-01

    Full Text Available A new technique for measuring the volume change of triaxial soil sample is presented in this research. A digital camera located at a fixed location takes images from the sample during the test. An edge detection procedure based on wavelet transform is introduced. This method can effectively trace the sample boundaries. Refraction of the light in water and plexiglass causes distortion and magnification of the image. Besides, errors induced by improper manufacturing of the lens may also cause image distortion. It is found that the nature of distortion for a triaxial soil sample is very complicated and no theoretical method is available for its calibration. Indeed, conventional regression methods fail for this problem. A feed forward back propagation neural network is used as a pattern recognition tool. The trained network can recognize the pattern of distortion and the corresponding errors are eliminated. This method can be adopted as an easy and inexpensive approach for unsaturated soils, where the soil volume change cannot be determined from the net water flow into or out of the soil specimen. The results of volume changes obtained by this method are in good agreement with the conventional method for saturated soils.

  6. Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry.

    Science.gov (United States)

    Knolhoff, Ann M; Nautiyal, Katherine M; Nemes, Peter; Kalachikov, Sergey; Morozova, Irina; Silver, Rae; Sweedler, Jonathan V

    2013-03-19

    The integration of disparate data types provides a more complete picture of complex biological systems. Here we combine small-volume metabolomic and transcriptomic platforms to determine subtle chemical changes and to link metabolites and genes to biochemical pathways. Capillary electrophoresis-mass spectrometry (CE-MS) and whole-genome gene expression arrays, aided by integrative pathway analysis, were utilized to survey metabolomic/transcriptomic hippocampal neurochemistry. We measured changes in individual hippocampi from the mast cell mutant mouse strain, C57BL/6 Kit(W-sh/W-sh). These mice have a naturally occurring mutation in the white spotting locus that causes reduced c-Kit receptor expression and an inability of mast cells to differentiate from their hematopoietic progenitors. Compared with their littermates, the mast cell-deficient mice have profound deficits in spatial learning, memory, and neurogenesis. A total of 18 distinct metabolites were identified in the hippocampus that discriminated between the C57BL/6 Kit(W-sh/W-sh) and control mice. The combined analysis of metabolite and gene expression changes revealed a number of altered pathways. Importantly, results from both platforms indicated that multiple pathways are impacted, including amino acid metabolism, increasing the confidence in each approach. Because the CE-MS and expression profiling are both amenable to small-volume analysis, this integrated analysis is applicable to a range of volume-limited biological systems. PMID:23409944

  7. Lifeline electric rates and alternative approaches to the problems of low-income ratepayers: ten case studies of rejected programs

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    This volume, Volume 3, contains ten case studies of non-implemented programs. It is noted that in Volume 2, the implemented lifeline programs, evolved as policy closely after the 1973 oil embargo; in contrast, the rejected programs were initiated about 4 years later and considered in a more-complex policy environment - after which time alternate methods of assisting low-income people had been developed. Specifically presented here are program summary, issue development, governmental process, and impact for the following: (a) Delaware Senate Bill 202; (b) Illinois House Bill 83; (c) Maine Legislative Document No. 1043; (d) Minnesota House File 1243; (e) New York Assembly Bill 12214; (f) New York Senate Bill 7013-A; (g) Rhode Island Resolution 79-H 5770-A; (h) South Dakota Senate Joint Resolution 9; (i) West Virginia House Bill 943; and (j) Wisconsin Assembly Bill 1250. 4 figures, 24 tables.

  8. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    This NASAP assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improvng the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness

  9. A white matter lesion-filling approach to improve brain tissue volume measurements

    Directory of Open Access Journals (Sweden)

    Sergi Valverde

    2014-01-01

    Full Text Available Multiple sclerosis white matter (WM lesions can affect brain tissue volume measurements of voxel-wise segmentation methods if these lesions are included in the segmentation process. Several authors have presented different techniques to improve brain tissue volume estimations by filling WM lesions before segmentation with intensities similar to those of WM. Here, we propose a new method to refill WM lesions, where contrary to similar approaches, lesion voxel intensities are replaced by random values of a normal distribution generated from the mean WM signal intensity of each two-dimensional slice. We test the performance of our method by estimating the deviation in tissue volume between a set of 30 T1-w 1.5 T and 30 T1-w 3 T images of healthy subjects and the same images where: WM lesions have been previously registered and afterwards replaced their voxel intensities to those between gray matter (GM and WM tissue. Tissue volume is computed independently using FAST and SPM8. When compared with the state-of-the-art methods, on 1.5 T data our method yields the lowest deviation in WM between original and filled images, independently of the segmentation method used. It also performs the lowest differences in GM when FAST is used and equals to the best method when SPM8 is employed. On 3 T data, our method also outperforms the state-of-the-art methods when FAST is used while performs similar to the best method when SPM8 is used. The proposed technique is currently available to researchers as a stand-alone program and as an SPM extension.

  10. The study of wear behaviors on abducted hip joint prostheses by an alternate finite element approach.

    Science.gov (United States)

    Lin, Yi-Tsung; Wu, James Shih-Shyn; Chen, Jian-Horng

    2016-07-01

    An acetabular cup with larger abduction angles is able to affect the normal function of the cup seriously that may cause early failure of the total hip replacement (THR). Complexity of the finite element (FE) simulation in the wear analysis of the THR is usually concerned with the contact status, the computational effort, and the possible divergence of results, which become more difficult on THRs with larger cup abduction angles. In the study, we propose a FE approach with contact transformation that offers less computational effort. Related procedures, such as Lagrangian Multiplier, partitioned matrix inversion, detection of contact forces, continuity of contact surface, nodal area estimation, etc. are explained in this report. Through the transformed methodology, the computer round-off error is tremendously reduced and the embedded repetitive procedure can be processed precisely and quickly. Here, wear behaviors of THR with various abduction angles are investigated. The most commonly used combination, i.e., metal-on-polyethylene, is adopted in the current study where a cobalt-chromium femoral head is paired with an Ultra High Molecular Weight Polyethylene (UHMWPE) cup. In all illustrations, wear coefficients are estimated by self-averaging strategy with available experimental datum reported elsewhere. The results reveal that the THR with larger abduction angles may produce deeper depth of wear but the volume of wear presents an opposite tendency; these results are comparable with clinical and experimental reports. The current approach can be widely applied easily to fields such as the study of the wear behaviors on ante-version, impingement, and time-dependent behaviors of prostheses etc. PMID:27265055

  11. Final programmatic environmental impact statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 2: Appendices

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky, Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. DOE's preferred alternative is to begin conversion of the depleted UF6 inventory as soon as possible, either to uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible. This volume contains Appendices A--O

  12. Model‐Based Assessment of Alternative Study Designs in Pediatric Trials. Part II: Bayesian Approaches

    Science.gov (United States)

    Smania, G; Baiardi, P; Ceci, A; Magni, P

    2016-01-01

    This study presents a pharmacokinetic‐pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed‐sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non‐hierarchical (NON‐H) and a semi‐hierarchical (SEMI‐H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of response to treatment between the pediatric and adult populations. Study designs were evaluated in terms of: type I and II errors, sample size per arm (SS), trial duration (TD), and estimate precision. No substantial differences were observed between NON‐H and SEMI‐H. BSDs require, on average, smaller SS and TD compared to the BD, which, on the other hand, guarantees higher estimate precision. When large differences between children and adults are expected, BSDs can return very large SS. Bayesian approaches appear to outperform their frequentist counterparts in the design of pediatric trials even when little weight is given to prior information from adults. PMID:27530374

  13. Alternative technological approach for synthesis of ceramic pigments by waste materials recycling

    International Nuclear Information System (INIS)

    Alternative technological approach is proposed enabling utilization of raw materials from an oil refinery, such as waste guard layers from reactors. Reagent grade and purified MgO, Cr2O3, Fe2O3, and nitric acid (HNO3), were used as additional precursors. The homogeneous mixtures obtained were formed into pellets and sintered at different temperatures. The main phase was proved by X-ray phase analysis (XRD) and compared to ICPDS database. The main phase in the ceramics synthesized was solid solution of spinel MgAl2O4 and magnesiochromite. These minerals are classified as chromspinelide MgCr1.2Al0.4Fe0.4O4 and alumochromite MgCr1.6Al0.4O4. Additional SEM observations, combined with EDX analysis were performed, evincing agglomeration at lower temperatures, followed by agglomerate crumbling, at elevated calcination temperature. The complete transformation of initial precursors into the final ceramic compounds was found to occur at 800 degree centigrade 1 h. The ceramic samples synthesized had high density of 1.72-1.93 g/cm3 and large absorption area - 32.93% which is probably due to the high porosity of the sample. (Author)

  14. An alternative approach to measure similarity between two deterministic transient signals

    Science.gov (United States)

    Shin, Kihong

    2016-06-01

    In many practical engineering applications, it is often required to measure the similarity of two signals to gain insight into the conditions of a system. For example, an application that monitors machinery can regularly measure the signal of the vibration and compare it to a healthy reference signal in order to monitor whether or not any fault symptom is developing. Also in modal analysis, a frequency response function (FRF) from a finite element model (FEM) is often compared with an FRF from experimental modal analysis. Many different similarity measures are applicable in such cases, and correlation-based similarity measures may be most frequently used among these such as in the case where the correlation coefficient in the time domain and the frequency response assurance criterion (FRAC) in the frequency domain are used. Although correlation-based similarity measures may be particularly useful for random signals because they are based on probability and statistics, we frequently deal with signals that are largely deterministic and transient. Thus, it may be useful to develop another similarity measure that takes the characteristics of the deterministic transient signal properly into account. In this paper, an alternative approach to measure the similarity between two deterministic transient signals is proposed. This newly proposed similarity measure is based on the fictitious system frequency response function, and it consists of the magnitude similarity and the shape similarity. Finally, a few examples are presented to demonstrate the use of the proposed similarity measure.

  15. Alternative technological approach for synthesis of ceramic pigments by waste materials recycling

    Energy Technology Data Exchange (ETDEWEB)

    Doynov, M.; Dimitrov, T.; Kozhukharov, S.

    2016-05-01

    Alternative technological approach is proposed enabling utilization of raw materials from an oil refinery, such as waste guard layers from reactors. Reagent grade and purified MgO, Cr{sub 2}O{sub 3}, Fe{sub 2}O{sub 3}, and nitric acid (HNO{sub 3}), were used as additional precursors. The homogeneous mixtures obtained were formed into pellets and sintered at different temperatures. The main phase was proved by X-ray phase analysis (XRD) and compared to ICPDS database. The main phase in the ceramics synthesized was solid solution of spinel MgAl{sub 2}O{sub 4} and magnesiochromite. These minerals are classified as chromspinelide MgCr{sub 1}.2Al{sub 0}.4Fe{sub 0}.4O{sub 4} and alumochromite MgCr{sub 1}.6Al{sub 0}.4O{sub 4}. Additional SEM observations, combined with EDX analysis were performed, evincing agglomeration at lower temperatures, followed by agglomerate crumbling, at elevated calcination temperature. The complete transformation of initial precursors into the final ceramic compounds was found to occur at 800 degree centigrade 1 h. The ceramic samples synthesized had high density of 1.72-1.93 g/cm{sup 3} and large absorption area - 32.93% which is probably due to the high porosity of the sample. (Author)

  16. Acute toxicity testing of chemicals-Opportunities to avoid redundant testing and use alternative approaches.

    Science.gov (United States)

    Creton, Stuart; Dewhurst, Ian C; Earl, Lesley K; Gehen, Sean C; Guest, Robert L; Hotchkiss, Jon A; Indans, Ian; Woolhiser, Michael R; Billington, Richard

    2010-01-01

    Assessment of the acute systemic oral, dermal, and inhalation toxicities, skin and eye irritancy, and skin sensitisation potential of chemicals is required under regulatory schemes worldwide. In vivo studies conducted to assess these endpoints can sometimes be associated with substantial adverse effects in the test animals, and their use should always be scientifically justified. It has been argued that while information obtained from such acute tests provides data needed to meet classification and labelling regulations, it is of limited value for hazard and risk assessments. Inconsistent application of in vitro replacements, protocol requirements across regions, and bridging principles also contribute to unnecessary and redundant animal testing. Assessment of data from acute oral and dermal toxicity testing demonstrates that acute dermal testing rarely provides value for hazard assessment purposes when an acute oral study has been conducted. Options to waive requirements for acute oral and inhalation toxicity testing should be employed to avoid unnecessary in vivo studies. In vitro irritation models should receive wider adoption and be used to meet regulatory needs. Global requirements for sensitisation testing need continued harmonisation for both substance and mixture assessments. This paper highlights where alternative approaches or elimination of tests can reduce and refine animal use for acute toxicity requirements. PMID:20144136

  17. An alternative approach for reusing slags from a plasma vitrification process

    Energy Technology Data Exchange (ETDEWEB)

    Kuo, Y.-M. [Department of Safety Health and Environmental Engineering, Chung Hwa University of Medical Technology, 89, Wenhwa 1st St., Rende Shiang, Tainan County 71703, Taiwan (China)], E-mail: yiming@mail.hwai.edu.tw; Tseng, H.-J. [Department of Foundry Engineering, National Tainan Industrial Vocational High School, Tainan 71075, Taiwan (China); Chang, J.-E. [Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan (China); Sustainable Environment Research Center, National Cheng Kung University, Tainan 70101, Taiwan (China); Wang, J.-W.; Wang, C.-T. [Department of Safety Health and Environmental Engineering, Chung Hwa University of Medical Technology, 89, Wenhwa 1st St., Rende Shiang, Tainan County 71703, Taiwan (China); Chen, H.-T. [Sustainable Environment Research Center, National Cheng Kung University, Tainan 70101, Taiwan (China)

    2008-08-15

    Vitrification is widely applied to transform hazardous materials into inert slags. Raising the value of the recycled slag is an important issue from an economic point of view. In this study, an alternative approach for mixing a plasma slag with unsaturated polyester resin for making the dough-like molding composites is proposed. Physical properties, including ultimate tensile strength, Rockwell hardness, and the elongation at break, were measured to evaluate the characteristics of the composites. A scanning electron microscope and an X-ray diffractometer were used to examine the micro characteristics of the specimens. The chemical stability of the composites was estimated using the toxicity characteristic leaching procedure and a hot water bathing process. In an optimal slag loading (mass ratio of slag to unsaturated polyester resin) ranged from 0.1 to 0.2, the slag powder improved the physical properties of the composites. With an increased slag loading, excess slag powder weakened the structure of the resin, reducing the ultimate tensile strength and Rockwell hardness. The acid and water bathing tests indicated that the resin is decomposed in a hot environment. However, the slag was not destructed nor were the hazardous metals leached out. The results show that the molding method is an effective technology to recycle the slag.

  18. An alternative approach for reusing slags from a plasma vitrification process.

    Science.gov (United States)

    Kuo, Yi-Ming; Tseng, Ho-Jung; Chang, Juu-En; Wang, Jian-Wen; Wang, Chih-Ta; Chen, Hung-Ta

    2008-08-15

    Vitrification is widely applied to transform hazardous materials into inert slags. Raising the value of the recycled slag is an important issue from an economic point of view. In this study, an alternative approach for mixing a plasma slag with unsaturated polyester resin for making the dough-like molding composites is proposed. Physical properties, including ultimate tensile strength, Rockwell hardness, and the elongation at break, were measured to evaluate the characteristics of the composites. A scanning electron microscope and an X-ray diffractometer were used to examine the micro characteristics of the specimens. The chemical stability of the composites was estimated using the toxicity characteristic leaching procedure and a hot water bathing process. In an optimal slag loading (mass ratio of slag to unsaturated polyester resin) ranged from 0.1 to 0.2, the slag powder improved the physical properties of the composites. With an increased slag loading, excess slag powder weakened the structure of the resin, reducing the ultimate tensile strength and Rockwell hardness. The acid and water bathing tests indicated that the resin is decomposed in a hot environment. However, the slag was not destructed nor were the hazardous metals leached out. The results show that the molding method is an effective technology to recycle the slag. PMID:18243535

  19. An alternative approach to modeling genetic merit of feed efficiency in dairy cattle.

    Science.gov (United States)

    Lu, Y; Vandehaar, M J; Spurlock, D M; Weigel, K A; Armentano, L E; Staples, C R; Connor, E E; Wang, Z; Bello, N M; Tempelman, R J

    2015-09-01

    Genetic improvement of feed efficiency (FE) in dairy cattle requires greater attention given increasingly important resource constraint issues. A widely accepted yet occasionally contested measure of FE in dairy cattle is residual feed intake (RFI). The use of RFI is limiting for several reasons, including interpretation, differences in recording frequencies between the various component traits that define RFI, and potential differences in genetic versus nongenetic relationships between dry matter intake (DMI) and FE component traits. Hence, analyses focusing on DMI as the response are often preferred. We propose an alternative multiple-trait (MT) modeling strategy that exploits the Cholesky decomposition to provide a potentially more robust measure of FE. We demonstrate that our proposed FE measure is identical to RFI provided that genetic and nongenetic relationships between DMI and component traits of FE are identical. We assessed both approaches (MT and RFI) by simulation as well as by application to 26,383 weekly records from 50 to 200 d in milk on 2,470 cows from a dairy FE consortium study involving 7 institutions. Although the proposed MT model fared better than the RFI model when simulated genetic and nongenetic associations between DMI and FE component traits were substantially different from each other, no meaningful differences were found in predictive performance between the 2 models when applied to the consortium data. PMID:26210274

  20. Alternative approach in 3D MEMS-IC integration using fluidic self-assembly techniques

    International Nuclear Information System (INIS)

    Nowadays, industries are investigating new, original and appropriate solutions to address challenges in 3D MEMS-IC large-scale integration. Self-assembly techniques are among those. We report on an alternative approach inspired from fluidic self-assembly and using the flip-chip method. Here, solder bumps are directly formed onto a MEMS chip using liquid solder solution in a bath. The self-alignment process is operated after surface treatment by plasma deposition to form high and low wettability selective patterns. Finally, MEMS and electronic chips are permanently bonded after low thermal heating without any pressure. Electrical contact is established and electromechanisms of the microsystems are proven. Compared to classic MEMS-IC flip-chip methods, this strategy presents many advantages: it is a low-cost and fast fabrication process requiring no specific equipment for deposition of solder bumps. Furthermore, it can be applied on different substrates and it does not require a specific pressure method during the bonding process. This strategy is also an appropriate fabrication method for large-scale MEMS integration where electronic connection density is high

  1. Mitigating global warming: traditional versus alternative approaches in a planning versus a market context

    Energy Technology Data Exchange (ETDEWEB)

    Olerup, Brita [Royal Inst. of Technology, Dept. of Industrial Economics and Management, Stockholm (Sweden)

    2002-06-01

    Economic efficiency tends to be an important argument when different means of environmental control are assessed and suggested. Considering that the most cost-efficient means are not the ones most frequently chosen and used, some other qualities seem to play an equally important role. I use findings from organisational theory and negotiation theory to better understand what is concealed in the black-box of decision-making and implementation. My empirical material consists of case studies of four different means of environmental control used in Sweden during the 1990s to mitigate the threat of global warming. These are an environmental tax, a licensing trial, municipal energy planning, and technology procurement. Each represents a particular discipline (economic, legal, physical planning, or technological) in which a context (planning or market) and an approach (traditional relay race or alternative process-oriented) are combined. Although each means has its particular niche, some qualities stand out as superior. Such means need to be divisible in space as well as in time. It is then easier to get started. Since it is just as easy to deviate from, rather than adhere to, the predetermined course after a while, some incentive must be given to the person in charge of implementation. In other words, the classic proverb of using sticks and carrots is still valid although it is not always taken to heart and practised. (Author)

  2. AN ALTERNATIVE APPROACH TO MEET BEEF SELF-SUFFICIENCY IN WEST PAPUA

    Directory of Open Access Journals (Sweden)

    S. Hartono

    2011-09-01

    Full Text Available The main objective of this research is to present an alternative approach to meet beef self-sufficiency in West Papua, Indonesia. It mainly focuses on calculating the needed number of productive cows to enhance beef production in the province. Out of the total farmer households in Manokwari, Indonesia, 189 farmer-respondents were selected as samples of the study. Selection of the sample was based on the number of cattle kept in every age group (less than one (2 years old and the number of productive cows. Secondary data came from the time series data of the number of slaughtered cattle vis-à-vis the population of all districts in West Papua Province from 1980-2008. Data were analyzed using the Partial Adjustment Model (PAM and Ordinary Least Square (OLS method. Results of the study showed that beef self-sufficiency in West Papua depend on the availability of the number of productive cows to produce ready-slaughtered-bull in the previous year. Particularly for West Papua, to produce one unit of bull in the tth –year, with the assumption that cattle mortality is 4.92%, a number of 2.38 animal units AU of productive cows must be provided in the previous two (2 years.

  3. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 1. Summary: alternatives for the back of the LWR fuel cycle types and properties of LWR fuel cycle wastes projections of waste quantities; selected glossary

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume I of the five-volume report contains executive and technical summaries of the entire report, background information of the LWR fuel cycle alternatives, descriptions of waste types, and projections of waste quantities. Overview characterizations of alternative LWR fuel cycle modes are also included. (JGB)

  4. A New Volume-Based Approach for Predicting Thermophysical Behavior of Ionic Liquids and Ionic Liquid Crystals.

    Science.gov (United States)

    Nelyubina, Yulia V; Shaplov, Alexander S; Lozinskaya, Elena I; Buzin, Mikhail I; Vygodskii, Yakov S

    2016-08-17

    Volume-based prediction of melting points and other properties of ionic liquids (ILs) relies on empirical relations with volumes of ions in these low-melting organic salts. Here we report an accurate way to ionic volumes by Bader's partitioning of electron densities from X-ray diffraction obtained via a simple database approach. For a series of 1-tetradecyl-3-methylimidazolium salts, the volumes of different anions are found to correlate linearly with melting points; larger anions giving lower-melting ILs. The volume-based concept is transferred to ionic liquid crystals (ILs that adopt liquid crystalline mesophases, ILCs) for predicting the domain of their existence from the knowledge of their constituents. For 1-alkyl-3-methylimidazolium ILCs, linear correlations of ionic volumes with the occurrence of LC mesophase and its stability are revealed, thus paving the way to rational design of ILCs by combining suitably sized ions. PMID:27479022

  5. An element-based finite-volume method approach for naturally fractured compositional reservoir simulation

    Energy Technology Data Exchange (ETDEWEB)

    Marcondes, Francisco [Federal University of Ceara, Fortaleza (Brazil). Dept. of Metallurgical Engineering and Material Science], e-mail: marcondes@ufc.br; Varavei, Abdoljalil; Sepehrnoori, Kamy [The University of Texas at Austin (United States). Petroleum and Geosystems Engineering Dept.], e-mails: varavei@mail.utexas.edu, kamys@mail.utexas.edu

    2010-07-01

    An element-based finite-volume approach in conjunction with unstructured grids for naturally fractured compositional reservoir simulation is presented. In this approach, both the discrete fracture and the matrix mass balances are taken into account without any additional models to couple the matrix and discrete fractures. The mesh, for two dimensional domains, can be built of triangles, quadrilaterals, or a mix of these elements. However, due to the available mesh generator to handle both matrix and discrete fractures, only results using triangular elements will be presented. The discrete fractures are located along the edges of each element. To obtain the approximated matrix equation, each element is divided into three sub-elements and then the mass balance equations for each component are integrated along each interface of the sub-elements. The finite-volume conservation equations are assembled from the contribution of all the elements that share a vertex, creating a cell vertex approach. The discrete fracture equations are discretized only along the edges of each element and then summed up with the matrix equations in order to obtain a conservative equation for both matrix and discrete fractures. In order to mimic real field simulations, the capillary pressure is included in both matrix and discrete fracture media. In the implemented model, the saturation field in the matrix and discrete fractures can be different, but the potential of each phase in the matrix and discrete fracture interface needs to be the same. The results for several naturally fractured reservoirs are presented to demonstrate the applicability of the method. (author)

  6. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 5. Appendices

    International Nuclear Information System (INIS)

    Volume V of the five-volume report consists of appendices, which provide supplementary information, with emphasis on characteristics of geologic formations that might be used for final storage or disposal. Appendix titles are: selected glossary; conversion factors; geologic isolation, including, (a) site selection factors for repositories of wastes in geologic media, (b) rock types--geologic occurrence, (c) glossary of geohydrologic terms, and (d) 217 references; the ocean floor; and, government regulations pertaining to the management of radioactive materials

  7. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 5. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume V of the five-volume report consists of appendices, which provide supplementary information, with emphasis on characteristics of geologic formations that might be used for final storage or disposal. Appendix titles are: selected glossary; conversion factors; geologic isolation, including, (a) site selection factors for repositories of wastes in geologic media, (b) rock types--geologic occurrence, (c) glossary of geohydrologic terms, and (d) 217 references; the ocean floor; and, government regulations pertaining to the management of radioactive materials. (JGB)

  8. Unravelling the politics of urban food transitions. A governance approach on Alternative Food Networks

    OpenAIRE

    Manganelli, Alessandra

    2015-01-01

    This contribution presents the analytical framework, research set-up and initial empirical operationalization of an early stage PhD research (Month 12) on the governance of Alternative Food Networks. Alternative Food Networks are alternative modes of organizing actors, resources and processes of the food chain, linking more closely food production with consumption. Civil society actors, such as activists, citizens’ groups, cooperatives, or several types of grass-root organizati...

  9. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    This assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improving the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness. The objectives of this assessment are to identify when economic incentives to deploy advanced nuclear power systems might exist, to estimate the costs of using technologies that would reduce the risk of proliferation, to assess the impact of major economic uncertainties on the transition to new technologies, and to compare the investments required for alternative systems. This information can then be used to assess the potential economic benefits of alternative research, development, and demonstration programs and the timing of those programs

  10. Sumerian: The Descendant of a Proto-Historical Creole? An Alternative Approach to the "Sumerian Problem." ROLIG-papir 51.

    Science.gov (United States)

    Hoyrup, Jens

    Problems in determining the origins of Sumerian, an ancient language, are described, and an alternative approach is examined. Sumerian was spoken in southern Iraq in the third millennium B.C. and later used by Babylonian and Assyrian scribes as a classical language. While early texts in Sumerian are considered a better reflection of the original…

  11. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    Science.gov (United States)

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  12. A pyramid-based approach to visual exploration of a large volume of vehicle trajectory data

    Institute of Scientific and Technical Information of China (English)

    Jing SUN; Xiang LI

    2012-01-01

    Advances in positioning and wireless communicating technologies make it possible to collect large volumes of trajectory data of moving vehicles in a fast and convenient fashion.These data can be applied to traffic studies.Behind this application,a methodological issue that still requires particular attention is the way these data should be spatially visualized.Trajectory data physically consists of a large number of positioning points.With the dramatic increase of data volume,it becomes a challenge to display and explore these data.Existing commercial software often employs vector-based indexing structures to facilitate the display of a large volume of points,but their performance downgrades quickly when the number of points is very large,for example,tens of millions.In this paper,a pyramid-based approach is proposed.A pyramid method initially is invented to facilitate the display of raster images through the tradeoff between storage space and display time.A pyramid is a set of images at different levels with different resolutions.In this paper,we convert vector-based point data into raster data,and build a gridbased indexing structure in a 2D plane.Then,an image pyramid is built.Moreover,at the same level of a pyramid,image is segmented into mosaics with respect to the requirements of data storage and management.Algorithms or procedures on grid-based indexing structure,image pyramid,image segmentation,and visualization operations are given in this paper.A case study with taxi trajectory data in Shanghai is conducted.Results demonstrate that the proposed method outperforms the existing commercial software.

  13. NUMERICAL SIMULATION OF ELECTRICAL IMPEDANCE TOMOGRAPHY PROBLEM AND STUDY OF APPROACH BASED ON FINITE VOLUME METHOD

    Directory of Open Access Journals (Sweden)

    Ye. S. Sherina

    2014-01-01

    Full Text Available This research has been aimed to carry out a study of peculiarities that arise in a numerical simulation of the electrical impedance tomography (EIT problem. Static EIT image reconstruction is sensitive to a measurement noise and approximation error. A special consideration has been given to reducing of the approximation error, which originates from numerical implementation drawbacks. This paper presents in detail two numerical approaches for solving EIT forward problem. The finite volume method (FVM on unstructured triangular mesh is introduced. In order to compare this approach, the finite element (FEM based forward solver was implemented, which has gained the most popularity among researchers. The calculated potential distribution with the assumed initial conductivity distribution has been compared to the analytical solution of a test Neumann boundary problem and to the results of problem simulation by means of ANSYS FLUENT commercial software. Two approaches to linearized EIT image reconstruction are discussed. Reconstruction of the conductivity distribution is an ill-posed problem, typically requiring a large amount of computation and resolved by minimization techniques. The objective function to be minimized is constructed of measured voltage and calculated boundary voltage on the electrodes. A classical modified Newton type iterative method and the stochastic differential evolution method are employed. A software package has been developed for the problem under investigation. Numerical tests were conducted on simulated data. The obtained results could be helpful to researches tackling the hardware and software issues for medical applications of EIT.

  14. Merging Alternate Remotely-Sensed Soil Moisture Retrievals Using a Non-Static Model Combination Approach

    Directory of Open Access Journals (Sweden)

    Seokhyeon Kim

    2016-06-01

    Full Text Available Soil moisture is an important variable in the coupled hydrologic and climate system. In recent years, microwave-based soil moisture products have been shown to be a viable alternative to in situ measurements. A popular way to measure the performance of soil moisture products is to calculate the temporal correlation coefficient (R against in situ measurements or other appropriate reference datasets. In this study, an existing linear combination method improving R was modified to allow for a non-static or nonstationary model combination as the basis for improving remotely-sensed surface soil moisture. Previous research had noted that two soil moisture products retrieved using the Japan Aerospace Exploration Agency (JAXA and Land Parameter Retrieval Model (LPRM algorithms from the same Advanced Microwave Scanning Radiometer 2 (AMSR2 sensor are spatially complementary in terms of R against a suitable reference over a fixed period. Accordingly, a linear combination was proposed to maximize R using a set of spatially-varying, but temporally-fixed weights. Even though this approach showed promising results, there was room for further improvements, in particular using non-static or dynamic weights that take account of the time-varying nature of the combination algorithm being approximated. The dynamic weighting was achieved by using a moving window. A number of different window sizes was investigated. The optimal weighting factors were determined for the data lying within the moving window and then used to dynamically combine the two parent products. We show improved performance for the dynamically-combined product over the static linear combination. Generally, shorter time windows outperform the static approach, and a 60-day time window is suggested to be the optimum. Results were validated against in situ measurements collected from 124 stations over different continents. The mean R of the dynamically-combined products was found to be 0.57 and 0

  15. Study on Macroscopic and Microscopic Mechanical Behavior of Magnetorheological Elastomers by Representative Volume Element Approach

    Directory of Open Access Journals (Sweden)

    Shulei Sun

    2014-01-01

    Full Text Available By using a representative volume element (RVE approach, this paper investigates the effective mechanical properties of anisotropic magnetorheological elastomers (MREs in which particles are aligned and form chain-like structure under magnetic field during curing. Firstly, a three-dimensional RVE in zero magnetic field is presented in ABAQUS/Standard to calculate the macroscopic mechanical properties of MREs. It is shown that the initial shear modulus of MREs increases by 56% with a 20% volume fraction of particles compared to that of pure rubber. Then by introducing the Maxwell stress tensor, a two-dimensional plane stress RVE for the MRE is developed in COMSOL Multiphysics to study its response under a magnetic field. The influences of magnetic field intensity, radius of particles, and distance between two adjacent particles on the macroscopic mechanical properties of MRE are also investigated. The results show that the shear modulus increases with the increase of the applied magnetic field intensity and the radius of particles and the decrease of the distance between two adjacent particles in a chain. The predicted numerical results are consistent with theoretical results from Mori-Tanaka model, double inclusion model, and dipole model.

  16. Transitioning From Volume to Value: A Strategic Approach to Design and Implementation.

    Science.gov (United States)

    Randazzo, Geralyn; Brown, Zenobia

    2016-01-01

    As the health care delivery system migrates toward a model based on value rather than volume, nursing leaders play a key role in assisting in the design and implementation of new models of care to support this transition. This article provides an overview of one organization's approach to evolve in the direction of value while gaining the experience needed to scope and scale cross-continuum assets to meet this growing demand. This article outlines the development and deployment of an organizational structure, information technology integration, clinical implementation strategies, and tools and metrics utilized to evaluate the outcomes of value-based programs. Experience in Bundled Payments for Care Improvement program is highlighted. The outcomes and lessons learned are incorporated for those interested in advancing value-based endeavors in their own organizations. PMID:26938185

  17. VOXEL-BASED APPROACH FOR ESTIMATING URBAN TREE VOLUME FROM TERRESTRIAL LASER SCANNING DATA

    Directory of Open Access Journals (Sweden)

    C. Vonderach

    2012-07-01

    Full Text Available The importance of single trees and the determination of related parameters has been recognized in recent years, e.g. for forest inventories or management. For urban areas an increasing interest in the data acquisition of trees can be observed concerning aspects like urban climate, CO2 balance, and environmental protection. Urban trees differ significantly from natural systems with regard to the site conditions (e.g. technogenic soils, contaminants, lower groundwater level, regular disturbance, climate (increased temperature, reduced humidity and species composition and arrangement (habitus and health status and therefore allometric relations cannot be transferred from natural sites to urban areas. To overcome this problem an extended approach was developed for a fast and non-destructive extraction of branch volume, DBH (diameter at breast height and height of single trees from point clouds of terrestrial laser scanning (TLS. For data acquisition, the trees were scanned with highest scan resolution from several (up to five positions located around the tree. The resulting point clouds (20 to 60 million points are analysed with an algorithm based on voxel (volume elements structure, leading to an appropriate data reduction. In a first step, two kinds of noise reduction are carried out: the elimination of isolated voxels as well as voxels with marginal point density. To obtain correct volume estimates, the voxels inside the stem and branches (interior voxels where voxels contain no laser points must be regarded. For this filling process, an easy and robust approach was developed based on a layer-wise (horizontal layers of the voxel structure intersection of four orthogonal viewing directions. However, this procedure also generates several erroneous "phantom" voxels, which have to be eliminated. For this purpose the previous approach was extended by a special region growing algorithm. In a final step the volume is determined layer-wise based on the

  18. A mixed finite element/finite volume approach for solving biodegradation transport in groundwater

    Science.gov (United States)

    Gallo, Claudio; Manzini, Gianmarco

    1998-03-01

    A numerical model for the simulation of flow and transport of organic compounds undergoing bacterial oxygen- and nitrate-based respiration is presented. General assumptions regarding microbial population, bacteria metabolism and effects of oxygen, nitrogen and nutrient concentration on organic substrate rate of consumption are briefly described. The numerical solution techniques for solving both the flow and the transport are presented. The saturated flow equation is discretized using a high-order mixed finite element scheme, which provides a highly accurate estimation of the velocity field. The transport equation for a sorbing porous medium is approximated using a finite volume scheme enclosing an upwind TVD shock-capturing technique for capturing concentration-unsteady steep fronts. The performance and capabilities of the present approach in a bio-remediation context are assessed by considering a set of test problems. The reliability of the numerical results concerning solution accuracy and the computational efficiency in terms of cost and memory requirements are also estimated.

  19. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities.

  20. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    International Nuclear Information System (INIS)

    The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities

  1. A New Approach for Deep Gray Matter Analysis Using Partial-Volume Estimation

    Science.gov (United States)

    Bonnier, Guillaume; Kober, Tobias; Schluep, Myriam; Du Pasquier, Renaud; Krueger, Gunnar; Meuli, Reto

    2016-01-01

    Introduction The existence of partial volume effects in brain MR images makes it challenging to understand physio-pathological alterations underlying signal changes due to pathology across groups of healthy subjects and patients. In this study, we implement a new approach to disentangle gray and white matter alterations in the thalamus and the basal ganglia. The proposed method was applied to a cohort of early multiple sclerosis (MS) patients and healthy subjects to evaluate tissue-specific alterations related to diffuse inflammatory or neurodegenerative processes. Method Forty-three relapsing-remitting MS patients and nineteen healthy controls underwent 3T MRI including: (i) fluid-attenuated inversion recovery, double inversion recovery, magnetization-prepared gradient echo for lesion count, and (ii) T1 relaxometry. We applied a partial volume estimation algorithm to T1 relaxometry maps to gray and white matter local concentrations as well as T1 values characteristic of gray and white matter in the thalamus and the basal ganglia. Statistical tests were performed to compare groups in terms of both global T1 values, tissue characteristic T1 values, and tissue concentrations. Results Significant increases in global T1 values were observed in the thalamus (p = 0.038) and the putamen (p = 0.026) in RRMS patients compared to HC. In the Thalamus, the T1 increase was associated with a significant increase in gray matter characteristic T1 (p = 0.0016) with no significant effect in white matter. Conclusion The presented methodology provides additional information to standard MR signal averaging approaches that holds promise to identify the presence and nature of diffuse pathology in neuro-inflammatory and neurodegenerative diseases. PMID:26845760

  2. Assessment of Energy Storage Alternatives in the Puget Sound Energy System Volume 2: Energy Storage Evaluation Tool

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Di; Jin, Chunlian; Balducci, Patrick J.; Kintner-Meyer, Michael CW

    2013-12-01

    This volume presents the battery storage evaluation tool developed at Pacific Northwest National Laboratory (PNNL), which is used to evaluate benefits of battery storage for multiple grid applications, including energy arbitrage, balancing service, capacity value, distribution system equipment deferral, and outage mitigation. This tool is based on the optimal control strategies to capture multiple services from a single energy storage device. In this control strategy, at each hour, a look-ahead optimization is first formulated and solved to determine battery base operating point. The minute by minute simulation is then performed to simulate the actual battery operation. This volume provide background and manual for this evaluation tool.

  3. Characterization of alternative electric generation technologies for the SPS comparative assessment: volume 2, central-station technologies

    International Nuclear Information System (INIS)

    The SPS Concept Development and Evaluation Program includes a comparative assessment. An early first step in the assessment process is the selection and characterization of alternative technologies. This document describes the cost and performance (i.e., technical and environmental) characteristics of six central station energy alternatives: (1) conventional coal-fired powerplant; (2) conventional light water reactor (LWR); (3) combined cycle powerplant with low-Btu gasifiers; (4) liquid metal fast breeder reactor (LMFBR); (5) photovoltaic system without storage; and (6) fusion reactor

  4. Alternative approaches of SiC & related wide bandgap materials in light emitting & solar cell applications

    Science.gov (United States)

    Wellmann, Peter; Syväjärvi, Mikael; Ou, Haiyan

    2014-03-01

    Materials for optoelectronics give a fascinating variety of issues to consider. Increasingly important are white light emitting diode (LED) and solar cell materials. Profound energy savings can be done by addressing new materials. White light emitting diodes are becoming common in our lighting scene. There is a great energy saving in the transition from the light bulb to white light emitting diodes via a transition of fluorescent light tubes. However, the white LEDs still suffer from a variety of challenges in order to be in our daily use. Therefore there is a great interest in alternative lighting solutions that could be part of our daily life. All materials create challenges in fabrication. Defects reduce the efficiency of optical transitions involved in the light emitting diode materials. The donor-acceptor co-doped SiC is a potential light converter for a novel monolithic all-semiconductor white LED. In spite of considerable research, the internal quantum efficiency is far less than theoretically predicted and is likely a fascinating scientific field for studying materials growth, defects and optical transitions. Still, efficient Si-based light source represents an ongoing research field in photonics that requires high efficiency at room temperature, wavelength tuning in a wide wavelength range, and easy integration in silicon photonic devices. In some of these devices, rare earth doped materials is considered as a potential way to provide luminescence spanning in a wide wavelength range. Divalent and trivalent oxidation states of Eu provide emitting centers in the visible region. In consideration, the use of Eu in photonics requires Eu doped thin films that are compatible with CMOS technology but for example faces material science issues like a low Eu solid solubility in silica. Therefore approaches aim to obtain efficient light emission from silicon oxycarbide which has a luminescence in the visible range and can be a host material for rare earth ions. The

  5. Assessment of potential impacts of municipal solid waste treatment alternatives by using life cycle approach: a case study in Vietnam.

    Science.gov (United States)

    Thanh, Nguyen Phuc; Matsui, Yasuhiro

    2013-10-01

    In Vietnam, most of municipal solid waste (MSW) is disposed of at open dumping and landfill sites, and the methane gas from waste is the un-ignorable source of greenhouse gas (GHG) emission. It is indispensable to explore the possibility for GHG mitigation in MSW management. The objective of this study was to estimate alternative waste treatment practices towards the GHG emission mitigation, energy consumption and generation, reduction of landfill volume, and various benefits for proposing the appropriate selection by scenario analyses for representative Vietnam's cities. Impacts were calculated by utilizing life cycle assessment (LCA) method. A literature review survey on the current applicability of LCA database for assessing impacts from waste sector in developing countries, especially for Vietnam, was carried out. This study assessed the contribution of alternative solid waste treatment practices. The result showed that, except investment and operation costs, incineration with energy recovery seems the suitable alternative for treating waste from representative cities of Vietnam according to reduction of GHG emission and waste burden to landfill sites and energy recovery and generation. Besides, MSW composition was identified as an important factor directly influencing to impacts as well as other products and benefits of waste treatment alternatives. Reliable data on waste composition are indispensable for assessing to choose, improve, or plan the waste treatment practices towards sustainable development. PMID:23475528

  6. Multi-criteria Planning Approach for Ranking of Land Management Alternatives at Different Spatial Scales

    OpenAIRE

    M. Reza Ghanbarpour; Keith W. Hipel

    2011-01-01

    Integrated land management decisions require comprehensive sets of criteria in order to properly account for all managerial alternatives. Economic criteria have been used to evaluate possible alternatives in most cases. However, it is important to consider the broadest possible range of social, economic and environmental criteria. This paper describes an integrated framework for land management planning at different spatial scales, comprising watershed, sub-watershed and land-unit levels. The...

  7. Carbon sequestration in Spanish Mediterranean forest under two management alternatives: A modeling approach

    OpenAIRE

    Bravo Oviedo, Felipe; Bravo Oviedo, Andrés; Díaz Balteiro, Luis

    2008-01-01

    Management implications associated with two different silvicultural strategies in two Spanish pine forests (Scots pine stands in northern Spain and Mediterranean Maritime pine stands in Central Spain) were explored. Whole-stand yield, growth models and individual tree equations were used to estimate carbon stock in forests under different silvicultural alternatives and site indexes. Each alternative was evaluated on the basis of the land expectation value (LEV). Results reveal the appropriate...

  8. Probing Aircraft Flight Test Hazard Mitigation for the Alternative Fuel Effects on Contrails and Cruise Emissions (ACCESS) Research Team . Volume 2; Appendices

    Science.gov (United States)

    Kelly, Michael J.

    2013-01-01

    The Alternative Fuel Effects on Contrails and Cruise Emissions (ACCESS) Project Integration Manager requested in July 2012 that the NASA Engineering and Safety Center (NESC) form a team to independently assess aircraft structural failure hazards associated with the ACCESS experiment and to identify potential flight test hazard mitigations to ensure flight safety. The ACCESS Project Integration Manager subsequently requested that the assessment scope be focused predominantly on structural failure risks to the aircraft empennage (horizontal and vertical tail). This report contains the Appendices to Volume I.

  9. New approach to the perception of 3D shape based on veridicality, complexity, symmetry and volume.

    Science.gov (United States)

    Pizlo, Zygmunt; Sawada, Tadamasa; Li, Yunfeng; Kropatsch, Walter G; Steinman, Robert M

    2010-01-01

    This paper reviews recent progress towards understanding 3D shape perception made possible by appreciating the significant role that veridicality and complexity play in the natural visual environment. The ability to see objects as they really are "out there" is derived from the complexity inherent in the 3D object's shape. The importance of both veridicality and complexity was ignored in most prior research. Appreciating their importance made it possible to devise a computational model that recovers the 3D shape of an object from only one of its 2D images. This model uses a simplicity principle consisting of only four a priori constraints representing properties of 3D shapes, primarily their symmetry and volume. The model recovers 3D shapes from a single 2D image as well, and sometimes even better, than a human being. In the rare recoveries in which errors are observed, the errors made by the model and human subjects are very similar. The model makes no use of depth, surfaces or learning. Recent elaborations of this model include: (i) the recovery of the shapes of natural objects, including human and animal bodies with limbs in varying positions (ii) providing the model with two input images that allowed it to achieve virtually perfect shape constancy from almost all viewing directions. The review concludes with a comparison of some of the highlights of our novel, successful approach to the recovery of 3D shape from a 2D image with prior, less successful approaches. PMID:19800910

  10. The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches

    International Nuclear Information System (INIS)

    The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling is complex and cost-intensive. Formalin-fixed paraffin-embedded specimens (FFPE) are easy to handle and economic to store, but their applicability for molecular methods is restricted. The recently introduced Hepes-glutamic acid-buffer mediated Organic solvent Protection Effect (HOPE) is a promising alternative, which might have the potential to unite the benefits of FFPE and fresh-frozen specimen. Aim of the study was to compare HOPE-fixed, FFPE and fresh-frozen bio-specimens for their accessibility for diagnostic and research purposes. 10 prostate cancer samples were each preserved with HOPE, formalin, and liquid nitrogen and studied with in-situ and molecular methods. Samples were H&E stained, and assessed by immunohistochemistry (i.e. PSA, GOLPH2, p63) and FISH (i.e. ERG rearrangement). We assessed DNA integrity by PCR, using control genes ranging from 100 to 600 bp amplicon size. RNA integrity was assessed through qRT-PCR on three housekeeping genes (TBP, GAPDH, β-actin). Protein expression was analysed by performing western blot analysis using GOLPH2 and PSA antibodies. Of the HOPE samples, morphologic quality of H&E sections, immunohistochemical staining, and the FISH assay was at least equal to FFPE tissue, and significantly better than the fresh-frozen specimens. DNA, RNA, and protein analysis of HOPE samples provided similar results as compared to fresh-frozen specimens. As expected, FFPE-samples were inferior for most of the molecular analyses. This is the first study, comparatively assessing the suitability of these fixation methods for diagnostic and research utilization. Overall, HOPE-fixed bio-specimens combine the benefits of FFPE- and fresh-frozen samples. Results of this study have the potential to expand on contemporary prostate tissue

  11. An alternative approach to determine attainable resolution directly from HREM images

    International Nuclear Information System (INIS)

    The concept of resolution in high-resolution electron microscopy (HREM) is the power to resolve neighboring atoms. Since the resolution is related to the width of the point spread function of the microscope, it could in principle be determined from the image of a point object. However, in electron microscopy there are no ideal point objects. The smallest object is an individual atom. If the width of an atom is much smaller than the resolution of the microscope, this atom can still be considered as a point object. As the resolution of the microscope enters the sub-Å regime, information about the microscope is strongly entangled with the information about the atoms in HREM images. Therefore, we need to find an alternative method to determine the resolution in an object-independent way. In this work we propose to use the image wave of a crystalline object in zone axis orientation. Under this condition, the atoms of a column act as small lenses so that the electron beam channels through the atom column periodically. Because of this focusing, the image wave of the column can be much more peaked than the constituting atoms and can thus be a much more sensitive probe to measure the resolution. Our approach is to use the peakiness of the image wave of the atom column to determine the resolution. We will show that the resolution can be directly linked to the total curvature of the atom column wave. Moreover, we can then directly obtain the resolution of the microscope given that the contribution from the object is known, which is related to the bounding energy of the atom. The method is applied on an experimental CaTiO3 image wave. - Highlights: • Microscope aberrations and the size of the atoms influence the resolution at the sub-Å level. • In channeling condition the atoms in the column focus the electron beam into a narrow peak at the exit face. • The shape of this peak can be used to determine the resolution in an object independent way. • This results in a

  12. The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches

    Directory of Open Access Journals (Sweden)

    Braun Martin

    2011-12-01

    Full Text Available Abstract Background The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling is complex and cost-intensive. Formalin-fixed paraffin-embedded specimens (FFPE are easy to handle and economic to store, but their applicability for molecular methods is restricted. The recently introduced Hepes-glutamic acid-buffer mediated Organic solvent Protection Effect (HOPE is a promising alternative, which might have the potential to unite the benefits of FFPE and fresh-frozen specimen. Aim of the study was to compare HOPE-fixed, FFPE and fresh-frozen bio-specimens for their accessibility for diagnostic and research purposes. Methods 10 prostate cancer samples were each preserved with HOPE, formalin, and liquid nitrogen and studied with in-situ and molecular methods. Samples were H&E stained, and assessed by immunohistochemistry (i.e. PSA, GOLPH2, p63 and FISH (i.e. ERG rearrangement. We assessed DNA integrity by PCR, using control genes ranging from 100 to 600 bp amplicon size. RNA integrity was assessed through qRT-PCR on three housekeeping genes (TBP, GAPDH, β-actin. Protein expression was analysed by performing western blot analysis using GOLPH2 and PSA antibodies. Results Of the HOPE samples, morphologic quality of H&E sections, immunohistochemical staining, and the FISH assay was at least equal to FFPE tissue, and significantly better than the fresh-frozen specimens. DNA, RNA, and protein analysis of HOPE samples provided similar results as compared to fresh-frozen specimens. As expected, FFPE-samples were inferior for most of the molecular analyses. Conclusions This is the first study, comparatively assessing the suitability of these fixation methods for diagnostic and research utilization. Overall, HOPE-fixed bio-specimens combine the benefits of FFPE- and fresh-frozen samples. Results of this study

  13. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    International Nuclear Information System (INIS)

    Volume IV provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

  14. Mixed strategies for energy conservation and alternative energy utilization (solar) in buildings. Final report. Volume III. Appendixes. [10 appendices

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-06-01

    This appendix summarizes building characteristics used to determine heating and cooling loads for each of the five building types in each of the four regions. For the selected five buildings, the following data are attached: new and existing construction characteristics; new and existing construction thermal resistance; floor plan and elevation; people load schedule; lighting load schedule; appliance load schedule; ventilation schedule; and hot water use schedule. For the five building types (single family, apartment buildings, commercial buildings, office buildings, and schools), data are compiled in 10 appendices. These are Building Characteristics; Alternate Energy Sources and Energy Conservation Techniques Description, Costs, Fuel Price Scenarios; Life Cycle Cost Model; Simulation Models; Solar Heating/Cooling System; Condensed Weather; Single and Multi-Family Dwelling Characteristics and Energy Conservation Techniques; Mixed Strategies for Energy Conservation and Alternative Energy Utilization in Buildings. An extensive bibliography is given in the final appendix. (MCW)

  15. Impacts of Alternative Marketing Agreement Cattle Procurement Volumes on Packer Costs: Evidence from Plant-Level P&L Data

    OpenAIRE

    Koontz, Stephen R.; Muth, Mary K.; Lawrence, John D.

    2007-01-01

    It has been argued that access to captive supply cattle improve the economic efficiency of beef packing facilities. However, this argument has not been subject to hypothesis testing. This work models the cost efficiencies associated with captive supplies or cattle we refer to as being sourced through alternative marketing agreements (AMAs). We find that slaughter and processing costs are lower ceteris paribus for AMA cattle than for cash market cattle. We find that plants that slaughter cattl...

  16. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VIII. Advanced concepts

    International Nuclear Information System (INIS)

    The six advanced concepts for nuclear power systems that were selected for evaluation are: the fast mixed-spectrum reactor; the denatured molten-salt reactor; the mixed-flow gaseous-core reactor; the linear-accelerator fuel-regenerator reactor; the ternary metal-fueled electronuclear fuel-producer reactor; and the tokamak fusion-fission hybrid reactor. The design assessment was performed by identifying needs in six specific areas: conceptual plant design; reactor-physics considerations; fuel cycle alternatives; mechanical and thermal-hydraulic considerations; selection, development, and availability of materials; and engineering and operability. While none of the six concepts appears to be a credible commercial alternative to the liquid-metal fast-breeder within the Nonproliferation Alternative Systems Assessment Program horizon of 2025, there are a number of reasons for continued interest in the fast mixed-spectrum reactor: it is a once-through cycle fast reactor with proliferation risk characteristics similar to those of the light-water reactor; only about one-third as much uranium is required as for the once-through light-water reactor; the system will benefit directly from fast-breeder development programs; and, finally, the research and development required to develop the high-burnup metal fuel could benefit the on-going liquid-metal fast-breeder reactor program. Accordingly, a limited research and development effort on the high-burnup fuel seems justified, at present

  17. Final Technical Report for Alternative Fuel Source Study-An Energy Efficient and Environmentally Friendly Approach

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Ralph [Auburn University, AL (United States); Schindler, Anton [Auburn University, AL (United States); Duke, Steve [Auburn University, AL (United States); Burch, Thom [Auburn University, AL (United States); Bransby, David [Auburn University, AL (United States); Stafford, Don [Lafarge North America, Inc., Alpharetta, GA (United States)

    2010-08-31

    The objective of this project is to conduct research to determine the feasibility of using alternate fuel sources for the production of cement. Successful completion of this project will also be beneficial to other commercial processes that are highly energy intensive. During this report period, we have completed all the subtasks in the preliminary survey. Literature searches focused on the types of alternative fuels currently used in the cement industry around the world. Information was obtained on the effects of particular alternative fuels on the clinker/cement product and on cement plant emissions. Federal regulations involving use of waste fuels were examined. Information was also obtained about the trace elements likely to be found in alternative fuels, coal, and raw feeds, as well as the effects of various trace elements introduced into system at the feed or fuel stage on the kiln process, the clinker/cement product, and concrete made from the cement. The experimental part of this project involves the feasibility of a variety of alternative materials mainly commercial wastes to substitute for coal in an industrial cement kiln in Lafarge NA and validation of the experimental results with energy conversion consideration.

  18. The R&D Evaluation in Italy: a survey of the CNR experience and a proposal fur alternative approach

    OpenAIRE

    Domiziano Boschi

    1998-01-01

    This paper analyses the evaluation experience of the most important Italian research agency (CNR). Focus is on the activity of the 15 consulting committees and on the National Finalised Projects managed by CNR on behalf of the University and Research Ministry. From this survey the author presents a proposal for an alternative approach of evaluation based on a wider range of instruments especially directed to evaluate the economic effects of the big research projects.

  19. Small volume of balls, large volume entropy and the Margulis constant

    OpenAIRE

    Sabourau, Stéphane

    2016-01-01

    In his seminal work about bounded cohomology, M. Gromov showed that, under some topological conditions, every closed Riemannian manifold of small volume has large volume entropy. In this article, we strengthen some aspects of this result using an alternative approach. More precisely, we prove that, under some similar, yet different, topological assumptions, every closed Riemannian manifold whose volume of balls is small has large volume entropy. Along the proof of this result, we establish a ...

  20. Communicative Competence Inventory for Students Who Use Augmentative and Alternative Communication: A Team Approach

    Science.gov (United States)

    Chung, Yun-Ching; Douglas, Karen H.

    2014-01-01

    Students who use augmentative and alternative communication (AAC) represent a heterogonous group with complex communication needs. AAC--including aided communication means (e.g., pictures, devices) and unaided (e.g., signs, gestures)--is often used to support students who have difficulties with speech production, language comprehension, and…

  1. A study of the diffusion of alternative fuel vehicles : An agent-based modeling approach

    NARCIS (Netherlands)

    Zhang, Ting; Gensler, Sonja; Garcia, Rosanna

    2011-01-01

    This paper demonstrates the use of an agent-based model (ABM) to investigate factors that can speed the diffusion of eco-innovations, namely alternative fuel vehicles (AFVs). The ABM provides the opportunity to consider the interdependencies inherent between key participants in the automotive indust

  2. Ipsative measurement and the analysis of organizational values: an alternative approach for data analysis

    NARCIS (Netherlands)

    F.M. van Eijnatten; L.A. van der Ark; S.S. Holloway

    2015-01-01

    In this paper, the analysis and test of ipsative data will be discussed, and some alternative methods will be suggested. Following a review of the literature about ipsative measurement, the Competing Values Framework will be presented as a major application in the field of organizational culture and

  3. INDOOR RADON REDUCTION IN CRAWL-SPACE HOUSES: A REVIEW OF ALTERNATIVE APPROACHES

    Science.gov (United States)

    An analysis has been completed of the performance, mechanisms, and costs of alternative technologies for preventing radon entry into the living areas of houses having crawl-space foundations. Sub-membrane depressurization (SMD) is consistently the most effective technique, often ...

  4. Ion Recognition Approach to Volume Reduction of Alkaline Tank Waste by Separation of Sodium Salts

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, Bruce A.; Bonnesen, Peter V.; Custelcean, Radu; Delmau, Laetitia H.; Engle, Nancy L.; Kang, Hyun-Ah; Keever, Tamara J.; Marchand, Alan P.; Gadthula, Srinivas; Gore, Vinayak K.; Huang, Zilin; Sivappa, Rasapalli; Tirunahari, Pavan K.; Levitskaia, Tatiana G.; Lumetta, Gregg J.

    2005-09-26

    The purpose of this research involving collaboration between Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL) is to explore new approaches to the separation of sodium hydroxide, sodium nitrate, and other sodium salts from high-level alkaline tank waste. The principal potential benefit is a major reduction in disposed waste volume, obviating the building of expensive new waste tanks and reducing the costs of vitrification. Principles of ion recognition are being researched toward discovery of liquid-liquid extraction systems that selectively separate sodium hydroxide and sodium nitrate from other waste components. The successful concept of pseudo hydroxide extraction using fluorinated alcohols and phenols is being developed at ORNL and PNNL toward a greater understanding of the controlling equilibria, role of solvation, and of synergistic effects involving crown ethers. Synthesis efforts are being directed toward enhanced sodium binding by crown ethers, both neutral and proton-ionizable. Studies with real tank waste at PNNL will provide feedback toward solvent compositions that have promising properties.

  5. Integrating Volume Reduction and Packaging Alternatives to Achieve Cost Savings for Low Level Waste Disposal at the Rocky Flats Environmental Technology Site

    International Nuclear Information System (INIS)

    In order to reduce costs and achieve schedules for Closure of the Rocky Flats Environmental Technology Site (RFETS), the Waste Requirements Group has implemented a number of cost saving initiatives aimed at integrating waste volume reduction with the selection of compliant waste packaging methods for the disposal of RFETS low level radioactive waste (LLW). Waste Guidance Inventory and Shipping Forecasts indicate that over 200,000 m3 of low level waste will be shipped offsite between FY2002 and FY2006. Current projections indicate that the majority of this waste will be shipped offsite in an estimated 40,000 55-gallon drums, 10,000 metal and plywood boxes, and 5000 cargo containers. Currently, the projected cost for packaging, shipment, and disposal adds up to $80 million. With these waste volume and cost projections, the need for more efficient and cost effective packaging and transportation options were apparent in order to reduce costs and achieve future Site packaging a nd transportation needs. This paper presents some of the cost saving initiatives being implemented for waste packaging at the Rocky Flats Environmental Technology Site (the Site). There are many options for either volume reduction or alternative packaging. Each building and/or project may indicate different preferences and/or combinations of options

  6. Final programmatic environmental impact statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 3: Responses to public comments

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky, Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. DOE's preferred alternative is to begin conversion of the depleted UF6 inventory as soon as possible, either to uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible. This volume of the Final PEIS contains the comments and DOE's responses to comments received during the comment period. Chapter 2 contains photocopies of written submissions received by DOE on the Draft PEIS; DOE's responses to those comments are listed in Chapter 3. Chapter 4 provides the oral comments received at the public hearings and DOE's responses. Chapter 5 provides indices to comments and responses arranged by commentor name and by comment number

  7. Forest stand volume: Can existing laser scanning methods based on the conventional one provide better results, acomparison of two approaches

    OpenAIRE

    Petr, Michal

    2007-01-01

    This paper looks at different datasets obtained from a recent Light Detection And Ranging (LiDAR) system acquisition and compares the reliability of two contemporary analysis approaches. Estimates of different tree variables, such as tree height, that were derived using regression analysis and a segmentation approach on data obtained via a small-footprint laser scan are contrasted with the field data for forest stand parameters, specifically volume and basal area. Plots of 2500 m2 containing ...

  8. A numerical-statistical approach to determining the representative elementary volume (REV) of cement paste for measuring diffusivity

    OpenAIRE

    Zhang, M. Z.; Ye, G.; van Breugel, K

    2010-01-01

    Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV), in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First,...

  9. Ion diode simulation with a finite-volume PIC approach for the numerical solution of the Maxwell-Lorentz system

    International Nuclear Information System (INIS)

    The numerical concept realized in the the Karlsruhe Diode Code KADI2D is briefly reviewed. Several new aspects concerning the Maxwell field solver based on high resolution finite-volume methods are presented. A new approach maintaining charge conservation numerically for the Maxwell-Lorentz equations is shortly summarized. (author). 2 figs., 12 refs

  10. Lessons learned from the financial crisis - unveiling alternative approaches within valuation and accounting theory

    OpenAIRE

    Gerrit Brosel; Martin Toll; Mario Zimmermann

    2012-01-01

    In the aftermath of the financial crisis, one of the most topical research questions is what caused it. We argue that one of the causes is the insufficient theoretical background employed in most valuation cases. Over the last six decades, there has been constructive debate between the proponents of the various valuation theories. However, the advocates of the Anglo-Saxon valuation theory seem unimpressed by the outcomes, claiming that there is no viable alternative to their preferred theory....

  11. Biomass Supply from Alternative Cellulosic Crops and Crop Residues: A Preliminary Spatial Bioeconomic Modeling Approach

    OpenAIRE

    Egbendewe-Mondzozo, Aklesso; Swinton, Scott M.; Izaurralde, R. Cesar; Manowitz, David H.; Zhang, Xuesong

    2010-01-01

    This paper introduces a spatial bioeconomic model for study of potential cellulosic biomass supply at regional scale. By modeling the profitability of alternative crop production practices, it captures the opportunity cost of replacing current crops by cellulosic biomass crops. The model draws upon biophysical crop input-output coefficients, price and cost data, and spatial transportation costs in the context of profit maximization theory. Yields are simulated using temperature, precipitation...

  12. Ballistic aggregation: an alternative approach to modeling of silica sol-gel structures

    Energy Technology Data Exchange (ETDEWEB)

    Grzegorczyk, Marcin; Rybaczuk, Marek; Maruszewski, Krzysztof

    2004-03-01

    An algorithm based on ballistic aggregation is discussed as an alternative to the commonly used, much slower diffusion-based algorithms for modeling of atomic structure of silica gels. The algorithm is shown to be capable of producing a wide range of structures: from extremely porous to compact (dense) ones. The importance of capture distance as a controlling parameter is discussed. Electron microscope images of actual silica gels morphologically very similar to the rendered images of the simulated aggregates are shown.

  13. Researching alternative, sustainable agricultural systems: A modelling approach by examples from Denmark

    OpenAIRE

    Alrøe, Hugo Fjelsted; Kristensen, Erik Steen

    2000-01-01

    In recent decades agriculture has undergone rapid technological and structural changes. This development has raised concerns about the sustainability of modern agriculture and motivated an interest in alternative and, perhaps, more sustainable agricultural systems. Agriculture involves both ecological and social systems, and research in agricultural systems therefore faces the dual challenge of understanding complex agro-ecosystem interactions and handling the involvement of human actors, the...

  14. Promoting functional foods as acceptable alternatives to doping: potential for information-based social marketing approach

    OpenAIRE

    Petróczi Andrea; Naughton Declan P; James Ricky

    2010-01-01

    Abstract Background Substances with performance enhancing properties appear on a continuum, ranging from prohibited performance enhancing drugs (PED) through dietary supplements to functional foods (FF). Anti-doping messages designed to dissuade athletes from using PEDs have been typically based on moralising sport competition and/or employing scare campaigns with focus on the negative consequences. Campaigns offering comparable and acceptable alternatives are nonexistent, nor are athletes he...

  15. TEACHING LISTENING THROUGH PHONOLOGY:AN ALTERNATIVE APPROACH FOR CHINESE TEACHERS OF ENGLISH

    Institute of Scientific and Technical Information of China (English)

    FrancisDoogan; MariaBjorningGyde

    2004-01-01

    With very limited exposure to spoken English, teachers in China are presented with a number of challenges in their own proficiency and subsequent teaching of listening and speaking, ranging from the type of approach they take to the teaching of these skills to the quality of voice which they model for their learners. A common approach to teaching listening in China

  16. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation.

    Science.gov (United States)

    McNamee, Pauline; Hibatallah, Jalila; Costabel-Farkas, Margit; Goebel, Carsten; Araki, Daisuke; Dufour, Eric; Hewitt, Nicola J; Jones, Penny; Kirst, Annette; Le Varlet, Béatrice; Macfarlane, Martin; Marrec-Fairley, Monique; Rowland, Joanna; Schellauf, Florian; Scheel, Julia

    2009-07-01

    The need for alternative approaches to replace the in vivo rabbit Draize eye test for evaluation of eye irritation of cosmetic ingredients has been recognised by the cosmetics industry for many years. Extensive research has lead to the development of several assays, some of which have undergone formal validation. Even though, to date, no single in vitro assay has been validated as a full replacement for the rabbit Draize eye test, organotypic assays are accepted for specific and limited regulatory purposes. Although not formally validated, several other in vitro models have been used for over a decade by the cosmetics industry as valuable tools in a weight of evidence approach for the safety assessment of ingredients and finished products. In light of the deadlines established in the EU Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision-tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. Furthermore, recommendations are given on how remaining data gaps and research needs can be addressed. PMID:19393279

  17. A Comparison of Two Different Approaches to Hydrazine Loading of Spacecraft: The Use of SCAPE and Alternative Approaches

    Science.gov (United States)

    Houseman, John; Patzold, Jack D.; Jackson, Julie R.; Brown, Pamela R.

    1999-01-01

    The loading of spacecraft with Hydrazine type fuels has long been recognized as a hazardous operation. This has led to safety strategies that include the use of SCAPE protective suits for personnel. The use of SCAPE suits have an excellent safety record, however there are associated drawbacks. Drawbacks include the high cost of maintaining and cleaning the suits, reduced mobility and dexterity when wearing the suits, the requirement for extensive specialized health and safety training, and the need to rotate personnel every two hours. A study was undertaken to look at procedures and/or equipment to eliminate or reduce the time spent in SCAPE-type operations. The major conclusions are drawn from observations of the loading of the JPL/NASA spacecraft Deep Space One (DS1) at KSC and the loading of a commercial communications satellite by Motorola at Vandenberg AF Base. The DS1 operations require extensive use of SCAPE suits, while the Motorola operation uses only SPLASH attire with a two-man team on standby in SCAPE. The Motorola team used very different loading equipment and procedures based on an integrated approach involving the propellant supplier. Overall, the Motorola approach was very clean, much faster and simpler than the DS1 procedure. The DS1 spacecraft used a bladder in the propellant tank, whereas the Motorola spacecraft used a Propellant Management Device (PMD). The Motorola approach cannot be used for tanks with bladders. To overcome this problem, some new procedures and new equipment are proposed to enable tanks with bladders to be loaded without using SCAPE, using a modified Motorola approach. Overall, it appears feasible to adopt the non-SCAPE approach while maintaining a very high degree of safety and reliability.

  18. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation.

    Science.gov (United States)

    Macfarlane, Martin; Jones, Penny; Goebel, Carsten; Dufour, Eric; Rowland, Joanna; Araki, Daisuke; Costabel-Farkas, Margit; Hewitt, Nicola J; Hibatallah, Jalila; Kirst, Annette; McNamee, Pauline; Schellauf, Florian; Scheel, Julia

    2009-07-01

    Evaluation of the skin irritancy and corrosivity potential of an ingredient is a necessity in the safety assessment of cosmetic ingredients. To date, there are two formally validated alternatives to the rabbit Draize test for skin corrosivity in place, namely the rat skin transcutaneous electrical resistance (TER) assay and the Human Skin Model Test using EpiSkin, EpiDerm and SkinEthic reconstructed human epidermal equivalents. For skin irritation, EpiSkin, EpiDerm and SkinEthic are validated as stand-alone test replacements for the rabbit Draize test. Data from these tests are rarely considered in isolation and are evaluated in combination with other factors to establish the overall irritating or corrosive potential of an ingredient. In light of the deadlines established in the Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. In conclusion, the safety assessments for skin irritation/corrosion of new chemicals for use in cosmetics can be confidently accomplished using exclusively alternative methods. PMID:19393278

  19. Correcting the systematic error of the density functional theory calculation: the alternate combination approach of genetic algorithm and neural network

    International Nuclear Information System (INIS)

    The alternate combinational approach of genetic algorithm and neural network (AGANN) has been presented to correct the systematic error of the density functional theory (DFT) calculation. It treats the DFT as a black box and models the error through external statistical information. As a demonstration, the AGANN method has been applied in the correction of the lattice energies from the DFT calculation for 72 metal halides and hydrides. Through the AGANN correction, the mean absolute value of the relative errors of the calculated lattice energies to the experimental values decreases from 4.93% to 1.20% in the testing set. For comparison, the neural network approach reduces the mean value to 2.56%. And for the common combinational approach of genetic algorithm and neural network, the value drops to 2.15%. The multiple linear regression method almost has no correction effect here. (condensed matter: structure, thermal and mechanical properties)

  20. Extracorporeal staple technique: an alternative approach to the treatment of critical colostomy stenosis

    OpenAIRE

    Skokowski, Jarosław; Bobowicz, Maciej; Kalinowska, Aleksandra

    2015-01-01

    We describe an extracorporeal staple technique used to treat severe colostomy stenosis under analgo-sedation, thus avoiding relaparotomy. The surgery is performed under short-term sedation. The orifice of the stoma is widened and overgrowing skin is excised. The volume and diameter of the stoma are assessed. The anvil of a circular stapler device is inserted into the lumen of the colostomy. First bowel layers and then skin are closed with purse-string sutures. One firing of the stapler is use...

  1. Atmospheric emissions modeling of energetic biomass alternatives using system dynamics approach

    International Nuclear Information System (INIS)

    To simulate the quantitative effects of regional biomass alternatives for energetic purpose (BfE) on air pollutant emissions, a system dynamics model was developed and applied for the EuRegion Austrian-Hungarian cross-border area. The dynamic simulation program VensimR was used to build an overall regional model with economic, social and environmental sectors. Within this model, the here-introduced regional air pollution sub-model (RegAir) includes the important human-made emissions of 10 pollutants resulting from all relevant source sectors within the region investigated. Emissions from activities related to biomass production, transport, conversion and final energy consumption were built in detail. After building and calibrating the RegAir model, seven quantitative test scenarios were defined and implemented into the world. Through the scenarios simulation, effects on air emissions were followed and compared over time. The results of these simulations show a significant reduction of CO2 emission, especially in cases where fossil fuel displacement in heating devices is achieved on the largest scale. On the contrary, traditional air pollutants increase by most BfE options. The results of the RegAir model simulations of BfE alternatives over two decades provide useful quantifications of various air emissions and identify the less pollutant BfE alternatives in the dynamic context of the relevant air pollution sources of the region. After minor structural modification and appropriate calibration, RegAir can be applied to other regions as well. However, it is stated that, to finally decide on the overall most-appropriate options at a regional level, other environmental as well as economic and social effects must be taken into consideration, being the latter the goal of the mentioned overall regional model which serves as a model frame to the RegAir tool. (author)

  2. Atmospheric emissions modeling of energetic biomass alternatives using system dynamics approach

    Science.gov (United States)

    Szarka, Nora; Kakucs, Orsolya; Wolfbauer, Jürgen; Bezama, Alberto

    To simulate the quantitative effects of regional biomass alternatives for energetic purpose (BfE) on air pollutant emissions, a system dynamics model was developed and applied for the EuRegion Austrian-Hungarian cross-border area. The dynamic simulation program Vensim ® was used to build an overall regional model with economic, social and environmental sectors. Within this model, the here-introduced regional air pollution sub-model (RegAir) includes the important human-made emissions of 10 pollutants resulting from all relevant source sectors within the region investigated. Emissions from activities related to biomass production, transport, conversion and final energy consumption were built in detail. After building and calibrating the RegAir model, seven quantitative test scenarios were defined and implemented into the model. Through the scenarios simulation, effects on air emissions were followed and compared over time. The results of these simulations show a significant reduction of CO 2 emissions, especially in cases where fossil fuel displacement in heating devices is achieved on the largest scale. On the contrary, traditional air pollutants increase by most BfE options. The results of the RegAir model simulations of BfE alternatives over two decades provide useful quantifications of various air emissions and identify the less pollutant BfE alternatives in the dynamic context of the relevant air pollution sources of the region. After minor structural modifications and appropriate calibration, RegAir can be applied to other regions as well. However, it is stated that, to finally decide on the overall most-appropriate options at a regional level, other environmental as well as economic and social effects must be taken into consideration, being the latter the goal of the mentioned overall regional model which serves as a model frame to the RegAir tool.

  3. Cost benefit indicators associated with the integration of alternative energy sources: A systems approach for Carinthia, Austria

    DEFF Research Database (Denmark)

    Wohlgemuth, N.

    Studies on how to promote the use of alternative energy sources (AES) typically focus on the relative efficiency and effectiveness of alternative subsidising mechanisms. Positive externalities of an increased AES utilisation are in general not explicitly taken into account. This paper analyses......, over the horizon to 2020, the technical and market penetration potentials of AES in the context of the Carinthian energy system. Apart from market penetration rates, cost benefit indicators are also computed to support the decision making process in the local energy and environmental policy. These...... indicators comprise import dependency, employment effects, capital expenditure, carbon dioxide emissions and government revenues. The systems approach adopted, the simultaneous consideration of not only market penetration rates but also of the associated economic indicators, gives a more complete picture of...

  4. The development, implementation and evaluation of alternative approaches to teaching and learning in the chemistry laboratory

    OpenAIRE

    Kelly, Orla

    2005-01-01

    The focus of the thesis is on the evaluation of the effect of the implementation of a three-hour per week problem-based learning (PBL) module for 1SI year undergraduate students. The research questions are outlined below: • What approaches to learning are undergraduate students adopting at the initial stage of tertiary education? • Are student approaches to learning related to age/gender/ time in university/achievement in examinations? • Can a PBL module in chemistry be developed ...

  5. An Alternative Approach to Water Regulations for Public Health Protection at Bathing Beaches

    OpenAIRE

    Abdelzaher, Amir M.; Solo-Gabriele, Helena M.; Phillips, Matthew C.; Elmir, Samir M.; Fleming, Lora E

    2013-01-01

    New approaches should be considered as the US Environmental Protection Agency (EPA) moves rapidly to develop new beach monitoring guidelines by the end of 2012, as these guidelines serve as the basis by which states and territories with coasts along the oceans and Great Lakes can then develop and implement monitoring programs for recreational waters. We describe and illustrate one possible approach to beach regulation termed as the “Comprehensive Toolbox within an Approval Process (CTBAP).” T...

  6. Alternative approaches for the treatment of airway diseases: focus on nanoparticle medicine.

    Science.gov (United States)

    Ratemi, E; Sultana Shaik, A; Al Faraj, A; Halwani, R

    2016-08-01

    Despite the various treatment options and international guidelines currently available for the appropriate therapeutic management of asthma, a large population of patients with asthma continues to have poorly controlled disease. There is therefore a need for novel approaches to achieve better asthma control, especially for severe asthmatics. This review discusses the use of nanoparticles for the specific targeting of inflammatory pathways as a promising approach for the effective control of severe persistent asthma as well as other chronic inflammatory diseases. PMID:27404025

  7. On alternative approaches to Lorentz violation in loop quantum gravity inspired models

    CERN Document Server

    Alfaro, J; Morales-Tecotl, H A; Urrutia, L F; Alfaro, Jorge; Reyes, Marat; Morales-Tecotl, Hugo A.

    2004-01-01

    Recent claims point out that possible violations of Lorentz symmetry appearing in some semiclassical models of extended matter dynamics motivated by loop quantum gravity can be removed by a different choice of canonically conjugated variables. In this note we show that such alternative is inconsistent with the choice of variables in the underlying quantum theory together with the semiclassical approximation, as long as the correspondence principle is maintained. A consistent choice will violate standard Lorentz invariance. Thus, to preserve a relativity principle in this framework, the linear realization of Lorentz symmetry should be extended or superseded.

  8. New volume and inverse volume operators for loop quantum gravity

    OpenAIRE

    Yang, Jinsong; Ma, Yongge

    2016-01-01

    A new alternative volume operator is constructed for loop quantum gravity by using the so-called co-triad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The ne...

  9. Transformation of theoretical-methodological approaches and methodical tools of the individual and territory welfare diagnostics. Part 1. From spreading to the alternative diagnostics approaches (background

    Directory of Open Access Journals (Sweden)

    Aleksandr Anatolyevich Kuklin

    2014-09-01

    Full Text Available This article presents an evolution of theoretical and methodological approaches to the welfare study. Existing theories of wellbeing are grouped according to accounted method of goods and resources distribution among society members. As a welfare future as a category we highlight objective (measured and subjective (estimated components. Based on the analysis of scientific literature we determine the ratio of individual and social welfare. The main differences between the categories of “ welfare” and “wealth” are given. The main difference consists in multidirectional changes of welfare and wealth for an increase (decrease in income of the individual (country. In this article we present an analysis of modern approaches to the definition of welfare: state, institutional and expendable approach. The welfare level estimation is complicated due to the need to consider the subjective component. The article provides an analysis of existing approaches to quantitative welfare evaluation ranging from the most common techniques (HDI, GDP to alternative techniques (Happy Planet Index.Methodological devices are structured by levels of welfare assessment objects (world, country, region, people. Based on the analysis of the advantages and disadvantages of methods we can conclude that the most reliable method is a comprehensive approach, which includes economic, environmental, social, vital and infrastructure indicators. The author’s approach to the formation of a complex methodological tool for individual and territory welfare estimation is presented in this article.

  10. Two-photon dilepton production in proton-proton collisions: Two alternative approaches

    Science.gov (United States)

    Łuszczak, Marta; Schäfer, Wolfgang; Szczurek, Antoni

    2016-04-01

    We investigate different methods to incorporate the effect of photons in hard processes. We compare the two different approaches used for calculating cross sections for the two-photon p p →l+l-X process. In one of the approaches the photon is treated as a collinear parton in the proton. In the second approach the recently proposed kT factorization method is used. We discuss how results of the collinear parton model depend on the initial condition for the QCD evolution and discuss an approximate treatment where the photon is excluded from the combined QCD-QED evolution. We demonstrate that it is not necessary to put the photon into the evolution equation as is often done, but it is sufficient to use a simplified approach in which the photon couples to quarks and antiquarks, which by themselves undergo DGLAP evolution equations. We discuss the sensitivity of the results to the choice of structure function parametrization and experimental cuts in the kT factorization approach. We explicitly display regions of x and Q2 (arguments of structure functions) relevant for different experiments. We compare the results of our calculations with recent experimental data for dilepton production and find that in most cases the contribution of the photon-photon mechanism is rather small. We discuss how to enhance the photon-photon contribution. We also compare our results to those of recent measurements of exclusive and semiexclusive e+e- pair production with certain experimental data by the CMS Collaboration.

  11. Motivation and Dispositions: Alternative Approaches to Explain the Performance of Critical Thinking Skills

    Directory of Open Access Journals (Sweden)

    Jorge Valenzuela

    2014-10-01

    Full Text Available Critical thinking depends on the mastery degrees of some skills and on the will to activate them when reasoning. Traditionally, this second aspect has been focused from a disposition approach (Facione, 1990. However, this perspective demonstrates problems in theoretical as in practical level to explain and to develop critical thinking. For this, it is proposed to approach the problem from the Motivation perspective (Eccles and Wigfield, 2002. In this context, our research deals with the evaluation of the convenience to choose one perspective or another to explain the performance of critical thinking, both theoretically and in its predictive capacity. Thus, along with theoretically analyze the strengths and weaknesses of both approaches and it was compared measures of dispositions (CCTDI, motivation (EMPC and critical thinking (CCTST in a sample of Spanish university students. The results show that the variability in critical thinking performance is better explained by the motivation than by dispositional approach. Finally, the theoretical and practical convenience of motivational approach in this matter is discussed.

  12. Lifeline electric rates and alternative approaches to the problems of low-income ratepayers. Ten case studies of implemented programs

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Program summaries, issue developments, governmental processes, and impacts are discussed for 10 case studies dealing with lifeline electric rates and alternative approaches to the problems of low-income ratepayers, namely; the Boston Edison rate freeze; the California lifeline; Florida Power and Light conservation rate; the Iowa-Illinois Gas and Electric small-use rate; the Maine demonstration lifeline program; the Massachusetts Electric Company A-65 rate; the Michigan optional senior citizen rate; the Narragansett Electric Company A-65 SSI rate; the Northern States Power Company conservation rate break; and the Potomac Electric Power Company rate freeze. (MCW)

  13. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials.

  14. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

    International Nuclear Information System (INIS)

    The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials

  15. The use of alternative energy sources - the best approach to improving environmental situation in Azerbaijan

    International Nuclear Information System (INIS)

    Energy supply is essential in the development of Azerbaijan. However, it remains reliant on fossil fuels to supply country's energy demand that leads to the exhaustion of energy resources, while increasing environmental pollution in the region. Analysis of the present situation shows that in order to prevent global disasters we must change the existing energy systems. Azerbaijan must seek new ways of generating energy, which do not sacrifice the natural environment, and which protect the health of the population and which promote sustainable development of the region. International Ecoenergy Academy (IEA) has long been engaged in the development of projects on the use of alternative energy sources. Based on the results of studies we suggested that introduction of modern renewable energy technologies can help reduce the health impacts of air pollution and ecological effects of acid rains, hazards of greenhouse gas emissions and climate changes, while providing people with environmentally clean energy and new job opportunities. (authors)

  16. AN ALTERNATIVE APPROACH TO LOW FREQUENCY RF ACCELERATORS AND POWER SOURCES

    International Nuclear Information System (INIS)

    The Muon Collider and Neutrino Factory projects require low frequency rf cavities because the size and emittance of the muon beam is much larger than is usual for electron or proton beams. The range of 30 MHz to 200 MHz is of special interest. However, the size of an accelerator with low frequency will be impractically large if it is simply scaled up from usual designs. In addition, to get very high peak power in this range is difficult. Presented in this paper is an alternative structure that employs a quasi-lumped inductance that can significantly reduce the transverse size while keeping high gradient. Also addressed is a power compression scheme with a thyratron. This gives a possible solution to provide very high peak power

  17. The Chinese approach to complementary and alternative medicine treatment for interstitial cystitis/bladder pain syndrome.

    Science.gov (United States)

    Pang, Ran; Ali, Abdullah

    2015-12-01

    Management of interstitial cystitis/bladder pain syndrome (IC/BPS) remains a challenge due to poor understanding on its etiology. Complementary and alternative medicine (CAM), as an optional treatment, has been widely used, because no definitive conventional therapy is available. The different domain of CAM provides miscellaneous treatments for IC/BPS, which mainly include dietary modification, nutraceuticals, bladder training, biofeedback, yoga, massage, physical therapy, Qigong, traditional Chinese medicine and acupuncture. Clinical evidence has shown that each therapy can certainly benefit a portion of IC/BPS patients. However, the target patient group of each therapy has not been well studied and randomized, controlled trials are needed to further confirm the efficacy and reliability of CAM on managing IC/BPS. Despite these limitations, CAM therapeutic characteristics including non-invasive and effectiveness for specific patients allow clinicians and patients to realize multimodal and individualized therapy for IC/BPS. PMID:26816867

  18. The influence of trading volume on market efficiency: The DCCA approach

    Science.gov (United States)

    Sukpitak, Jessada; Hengpunya, Varagorn

    2016-09-01

    For a single market, the cross-correlation between market efficiency and trading volume, which is an indicator of market liquidity, is attentively analysed. The study begins with creating time series of market efficiency by applying time-varying Hurst exponent with one year sliding window to daily closing prices. The time series of trading volume corresponding to the same time period used for the market efficiency is derived from one year moving average of daily trading volume. Subsequently, the detrended cross-correlation coefficient is employed to quantify the degree of cross-correlation between the two time series. It was found that values of cross-correlation coefficient of all considered stock markets are close to 0 and are clearly out of range in which correlation being considered significant in almost every time scale. Obtained results show that the market liquidity in term of trading volume hardly has effect on the market efficiency.

  19. Different approaches to synovial membrane volume determination by magnetic resonance imaging: manual versus automated segmentation

    DEFF Research Database (Denmark)

    Østergaard, Mikkel

    1997-01-01

    methodology for volume determinations (maximal error 6.3%). Preceded by the determination of reproducibility and the optimal threshold at the available MR unit, automated 'threshold' segmentation appears to be acceptable when changes rather than absolute values of synovial membrane volumes are most important......, osteoarthritis (OA) 16] and 17 RA wrists were examined. At enhancement thresholds between 30 and 60%, the automated volumes (Syn(x%)) were highly significantly correlated to manual volumes (SynMan) (knees: rho = 0.78-0.91, P < 10(-5) to < 10(-9); wrists: rho = 0.87-0.95, P < 10(-4) to < 10(-6)). The absolute...... values of the automated estimates were extremely dependent on the threshold chosen. At the optimal threshold of 45%, the median numerical difference from SynMan was 7 ml (17%) in knees and 2 ml (25%) in wrists. At this threshold, the difference was not related to diagnosis, clinical inflammation or...

  20. Different approaches to synovial membrane volume determination by magnetic resonance imaging: manual versus automated segmentation

    DEFF Research Database (Denmark)

    Østergaard, Mikkel

    1997-01-01

    synovial membrane volume, e.g. no systematic errors were found. The inter-MRI variation, evaluated in three knees and three wrists, was higher than by manual segmentation, particularly due to sensitivity to malalignment artefacts. Examination of test objects proved the high accuracy of the general......Automated fast (5-20 min) synovial membrane volume determination by MRI, based on pre-set post-gadolinium-DTPA enhancement thresholds, was evaluated as a substitute for a time-consuming (45-120 min), previously validated, manual segmentation method. Twenty-nine knees [rheumatoid arthritis (RA) 13......, osteoarthritis (OA) 16] and 17 RA wrists were examined. At enhancement thresholds between 30 and 60%, the automated volumes (Syn(x%)) were highly significantly correlated to manual volumes (SynMan) (knees: rho = 0.78-0.91, P < 10(-5) to < 10(-9); wrists: rho = 0.87-0.95, P < 10(-4) to < 10(-6)). The absolute...

  1. An alternative approach to the Boltzmann distribution through the chemical potential

    Science.gov (United States)

    D'Anna, Michele; Job, Georg

    2016-05-01

    The Boltzmann distribution is one of the most significant results of classical physics. Despite its importance and its wide range of application, at high school level it is mostly presented without any derivation or link to some basic ideas. In this contribution we present an approach based on the chemical potential that allows to derive it directly from the basic idea of thermodynamical equilibrium.

  2. A Partnership Model for Evaluation: Considering an Alternate Approach to the Internal-External Evaluation Debate

    Science.gov (United States)

    Le Menestrel, Suzanne M.; Walahoski, Jill S.; Mielke, Monica B.

    2014-01-01

    The 4-H youth development organization is a complex public--private partnership between the U.S. Department of Agriculture's National Institute of Food and Agriculture, the nation's Cooperative Extension system and National 4-H Council, a private, nonprofit partner. The current article is focused on a partnership approach to the…

  3. A Suggested Approach for a Cost Analysis of Alternative IMS Configurations.

    Science.gov (United States)

    Besel, Ronald

    An approach to a cost analysis of pilot, prototype, model and operational versions of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS) is described. Five classes of systems (conceptual, pilot, prototype, model and operational) are defined, and a system development process relating classes of systems in presented.…

  4. Seconding Teachers to the Academy: An Alternative to Traditional Approaches of Sessional Staff Employment

    Science.gov (United States)

    Walkingtion, Jackie

    2014-01-01

    There is a multiplicity of challenges related to employing, supporting and retaining quality sessional (casual) academic staff in higher education. An approach trialled in an Australian education faculty specifically addressed issues of quality and quantity, support and inclusion, motivation and engagement, efficiency and effectiveness. While…

  5. An alternative approach for neural network evolution with a genetic algorithm: crossover by combinatorial optimization.

    Science.gov (United States)

    García-Pedrajas, Nicolás; Ortiz-Boyer, Domingo; Hervás-Martínez, César

    2006-05-01

    In this work we present a new approach to crossover operator in the genetic evolution of neural networks. The most widely used evolutionary computation paradigm for neural network evolution is evolutionary programming. This paradigm is usually preferred due to the problems caused by the application of crossover to neural network evolution. However, crossover is the most innovative operator within the field of evolutionary computation. One of the most notorious problems with the application of crossover to neural networks is known as the permutation problem. This problem occurs due to the fact that the same network can be represented in a genetic coding by many different codifications. Our approach modifies the standard crossover operator taking into account the special features of the individuals to be mated. We present a new model for mating individuals that considers the structure of the hidden layer and redefines the crossover operator. As each hidden node represents a non-linear projection of the input variables, we approach the crossover as a problem on combinatorial optimization. We can formulate the problem as the extraction of a subset of near-optimal projections to create the hidden layer of the new network. This new approach is compared to a classical crossover in 25 real-world problems with an excellent performance. Moreover, the networks obtained are much smaller than those obtained with classical crossover operator. PMID:16343847

  6. Postauricular Approach for Mandibular Angle Ostectomy: An Alternative for Shortening the Recovery Time.

    Science.gov (United States)

    Lim, Hyoseob; Kang, Minbum

    2016-01-01

    Many surgical procedures to improve mandibular contour have been introduced in East Asia. Despite consensus regarding mandible contouring surgery, surgery which includes angle ostectomy and lateral cortex excision, some patients require only mandibular angle ostectomy. The intraoral approach is a widely used method, but has disadvantages with regard to the need for endotracheal intubation and patients are limited in their food intake for a considerable length of time. The authors wanted to shorten the recovery period and so the postauricular approach is introduced in this study and assessed.One hundred seventy-five Asian patients underwent mandibular angle ostectomy via a postauricular approach. All operations were performed under intravenous sedation without endotracheal intubation. Superficial subcutaneous dissection and vertical dissection were performed, with special care taken to avoid injuring the facial nerve. Patients responded to a simple questionnaire during the postoperative period. Questions solicited the patient's reason for their choice of this approach and their satisfaction with it.No visible scar and no palpable bony step were observed without ear pulling. Some patients experienced temporary sensory changes in the postauricular area. None of the patients complained of perioral numbness or facial paralysis. Six patients had significant bleeding in the operative field and 1 patient experienced salivary leakage for 2 weeks which was managed well without event. Of the 175 patients, 133 responded to the questionnaire. Satisfaction was expressed by 94.7% of patients and 88.7% of patients would recommend this surgery to their friends; 69.2% of patients experienced inconvenience for 1 week or less.The postauricular approach for mandibular angle ostectomy is a very convenient method for surgeons to use for patients who want to undergo mandibular angle ostectomy with a short recovery time. PMID:25325390

  7. Interactive volume exploration of petascale microscopy data streams using a visualization-driven virtual memory approach

    KAUST Repository

    Hadwiger, Markus

    2012-12-01

    This paper presents the first volume visualization system that scales to petascale volumes imaged as a continuous stream of high-resolution electron microscopy images. Our architecture scales to dense, anisotropic petascale volumes because it: (1) decouples construction of the 3D multi-resolution representation required for visualization from data acquisition, and (2) decouples sample access time during ray-casting from the size of the multi-resolution hierarchy. Our system is designed around a scalable multi-resolution virtual memory architecture that handles missing data naturally, does not pre-compute any 3D multi-resolution representation such as an octree, and can accept a constant stream of 2D image tiles from the microscopes. A novelty of our system design is that it is visualization-driven: we restrict most computations to the visible volume data. Leveraging the virtual memory architecture, missing data are detected during volume ray-casting as cache misses, which are propagated backwards for on-demand out-of-core processing. 3D blocks of volume data are only constructed from 2D microscope image tiles when they have actually been accessed during ray-casting. We extensively evaluate our system design choices with respect to scalability and performance, compare to previous best-of-breed systems, and illustrate the effectiveness of our system for real microscopy data from neuroscience. © 1995-2012 IEEE.

  8. Alternative approach for fire suppression of class A, B and C fires in gloveboxes

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberger, Mark S [Los Alamos National Laboratory; Tsiagkouris, James A [Los Alamos National Laboratory

    2011-02-10

    Department of Energy (DOE) Orders and National Fire Protection Association (NFPA) Codes and Standards require fire suppression in gloveboxes. Several potential solutions have been and are currently being considered at Los Alamos National Laboratory (LANL). The objective is to provide reliable, minimally invasive, and seismically robust fire suppression capable of extinguishing Class A, B, and C fires; achieve compliance with DOE and NFPA requirements; and provide value-added improvements to fire safety in gloveboxes. This report provides a brief summary of current approaches and also documents the successful fire tests conducted to prove that one approach, specifically Fire Foe{trademark} tubes, is capable of achieving the requirement to provide reliable fire protection in gloveboxes in a cost-effective manner.

  9. Alternative Approach Strategies For Buyer-Seller Relations With The Peoples Republic Of China

    OpenAIRE

    Johnston, W.J.

    1988-01-01

    This paper examines the issues involved in buyer-seller relations for industrial product sales in the People's Republic of China. The need is genuine in many product categories including plant technology, high technology, and infrastructure. The problem is that buying policies and procedures for foreign firms are still emerging, and therefore, unclear and confusing. Three approach strategies for buyer-seller relations with China are presented: the authorized "buying group," the "agency" repre...

  10. An alternative approach for measuring black representation in Navy enlisted occupations

    OpenAIRE

    Dye, Gary B.

    1994-01-01

    This thesis examines the possible outcomes of U.S. Navy policies to achieve proportionru representation of blacks in enlisted occupations. This thesis employs two models to anruyze the distribution of black enlisted men in the Navy's occupational speciruties. The fIfst model uses FY 1979, FY 1982. FY 1985, and FY 1988 cohort data to examine black male occupational representation during the fifth year of service. This study introduces a new approach to control for the influence ...

  11. An Alternative Approach to Combine Orbital Prosthesis and Obturator: A Case Report

    OpenAIRE

    Soganci, Gokce; Yalug, Suat; Kocacikli, Mustafa

    2011-01-01

    This report describes a different approach for diminishing the movements of orbital prosthesis during mimic movements and chewing function. Mechanical devices such as magnets are used to enhance the retention in case lack of the implants. However rigid fixation of obturator and orbital prosthesis can result in movements of the orbital prosthesis during mastication. In this case obturator and orbital prosthesis are combined by magnets. However this combination is not rigid because of an active...

  12. A pilot study evaluating alternative approaches of academic detailing in rural family practice clinics

    Directory of Open Access Journals (Sweden)

    Hartung Daniel M

    2012-12-01

    Full Text Available Abstract Background Academic detailing is an interactive, convenient, and user-friendly approach to delivering non-commercial education to healthcare clinicians. While evidence suggests academic detailing is associated with improvements in prescribing behavior, uncertainty exists about generalizability and scalability in diverse settings. Our study evaluates different models of delivering academic detailing in a rural family medicine setting. Methods We conducted a pilot project to assess the feasibility, effectiveness, and satisfaction with academic detailing delivered face-to-face as compared to a modified approach using distance-learning technology. The recipients were four family medicine clinics within the Oregon Rural Practice-based Research Network (ORPRN. Two clinics were allocated to receive face-to-face detailing and two received outreach through video conferencing or asynchronous web-based outreach. Surveys at midpoint and completion were used to assess effectiveness and satisfaction. Results Each clinic received four outreach visits over an eight month period. Topics included treatment-resistant depression, management of atypical antipsychotics, drugs for insomnia, and benzodiazepine tapering. Overall, 90% of participating clinicians were satisfied with the program. Respondents who received in person detailing reported a higher likelihood of changing their behavior compared to respondents in the distance detailing group for five of seven content areas. While 90%-100% of respondents indicated they would continue to participate if the program were continued, the likelihood of participation declined if only distance approaches were offered. Conclusions We found strong support and satisfaction for the program among participating clinicians. Participants favored in-person approaches to distance interactions. Future efforts will be directed at quantitative methods for evaluating the economic and clinical effectiveness of detailing in rural

  13. Alternatives to relational databases in precision medicine: Comparison of NoSQL approaches for big data storage using supercomputers

    Science.gov (United States)

    Velazquez, Enrique Israel

    Improvements in medical and genomic technologies have dramatically increased the production of electronic data over the last decade. As a result, data management is rapidly becoming a major determinant, and urgent challenge, for the development of Precision Medicine. Although successful data management is achievable using Relational Database Management Systems (RDBMS), exponential data growth is a significant contributor to failure scenarios. Growing amounts of data can also be observed in other sectors, such as economics and business, which, together with the previous facts, suggests that alternate database approaches (NoSQL) may soon be required for efficient storage and management of big databases. However, this hypothesis has been difficult to test in the Precision Medicine field since alternate database architectures are complex to assess and means to integrate heterogeneous electronic health records (EHR) with dynamic genomic data are not easily available. In this dissertation, we present a novel set of experiments for identifying NoSQL database approaches that enable effective data storage and management in Precision Medicine using patients' clinical and genomic information from the cancer genome atlas (TCGA). The first experiment draws on performance and scalability from biologically meaningful queries with differing complexity and database sizes. The second experiment measures performance and scalability in database updates without schema changes. The third experiment assesses performance and scalability in database updates with schema modifications due dynamic data. We have identified two NoSQL approach, based on Cassandra and Redis, which seems to be the ideal database management systems for our precision medicine queries in terms of performance and scalability. We present NoSQL approaches and show how they can be used to manage clinical and genomic big data. Our research is relevant to the public health since we are focusing on one of the main

  14. An alternative approach to characterize the topology of complex networks and its application in epidemic spreading

    Institute of Scientific and Technical Information of China (English)

    Zonghua LIU; Xiaoyan WU; Pak-Ming HUI

    2009-01-01

    Based on the mean-field approach, epidemic spreading has been well studied. However, the mean-field approach cannot show the detailed contagion process, which is important in the control of epidemic. To fill this gap, we present a novel approach to study how the topological struc-ture of complex network influences the concrete process of epidemic spreading. After transforming the network struc-ture into hierarchical layers, we introduce a set of new pa-rameters, i.e., the average fractions of degree for outgoing, ingoing, and remaining in the same layer, to describe the infection process. We find that this set of parameters are closely related to the degree distribution and the clustering coefficient but are more convenient than them in describ-ing the process of epidemic spreading. Moreover, we find that the networks with exponential distribution have slower spreading speed than the networks with power-law degree distribution. Numerical simulations have confirmed the the-oretical predictions.

  15. Random spectrum loading of dental implants: An alternative approach to functional performance assessment.

    Science.gov (United States)

    Shemtov-Yona, K; Rittel, D

    2016-09-01

    The fatigue performance of dental implants is usually assessed on the basis of cyclic S/N curves. This neither provides information on the anticipated service performance of the implant, nor does it allow for detailed comparisons between implants unless a thorough statistical analysis is performed, of the kind not currently required by certification standards. The notion of endurance limit is deemed to be of limited applicability, given unavoidable stress concentrations and random load excursions, that all characterize dental implants and their service conditions. We propose a completely different approach, based on random spectrum loading, as long used in aeronautical design. The implant is randomly loaded by a sequence of loads encompassing all load levels it would endure during its service life. This approach provides a quantitative and comparable estimate of its performance in terms of lifetime, based on the very fact that the implant will fracture sooner or later, instead of defining a fatigue endurance limit of limited practical application. Five commercial monolithic Ti-6Al-4V implants were tested under cyclic, and another 5 under spectrum loading conditions, at room temperature and dry air. The failure modes and fracture planes were identical for all implants. The approach is discussed, including its potential applications, for systematic, straightforward and reliable comparisons of various implant designs and environments, without the need for cumbersome statistical analyses. It is believed that spectrum loading can be considered for the generation of new standardization procedures and design applications. PMID:27161957

  16. Rhodomyrtus tomentosa (Aiton) Hassk. leaf extract: An alternative approach for the treatment of staphylococcal bovine mastitis.

    Science.gov (United States)

    Mordmuang, Auemphon; Voravuthikunchai, Supayang Piyawan

    2015-10-01

    Antibiotic residues in dairy products as well as emergence of antimicrobial resistance in foodborne pathogens have been recognized as global public health concerns. The present work was aimed to study a potent antibacterial extract from natural product as an alternative treatment for staphylococcal bovine mastitis. Staphylococcal isolates (n=44) were isolated from milk samples freshly squeezed from individual cows. All staphylococcal isolates were resistant to ampicillin, ciprofloxacin, erythromycin, gentamicin, penicillin, except vancomycin. Rhodomyrtus tomentosa leaf ethanolic extract was accessed for its antibacterial activity and anti-inflammatory potential. The extract exhibited profound antibacterial activity against all of staphylococcal isolates with MIC and MBC values ranged from 16-64 μg/ml and 64->128 μg/ml, respectively. Moreover, the extract also exerted anti-protein denaturation and human red blood cell membrane stabilizing activity. The results support the use of R. tomentosa extract that could be applied to cure bovine mastitis and to reduce inflammatory injury caused by the bacterial infections. PMID:26412553

  17. Sutureless prepuceplasty with wound healing by second intention: An alternative surgical approach in children's phimosis treatment

    Directory of Open Access Journals (Sweden)

    Christianakis Efstratios

    2008-03-01

    Full Text Available Abstract Background A new technique for the treatment of children's phimosis is presented that minimizes the repairing time, the postoperative complications and maintains the physical foreskin appearance intact. Methods Eightyseven children with phimosis were treated with this new developed technique, between 2003 and 2005. Sutureless prepuceplasty creates a permanent surgical extension of the close prepuce. Stretching and retraction of phimotic foreskin reveals a tight prepuce ring that is cutting in its dorsal surface longitudinally. Rarely triple symmetric incisions in the preputial outlet are necessary. The foreskin is loose and moves absolutely free in bilateral courses. The wounds are healing by second intention. Antisepsis, steroids and Elicina cream, (which contains allantoin, collagen, elastin, glycolic acid and vitamins A, D, and E should apply daily, for twenty to thirty days. Results The foreskin is moving in centripetal or efferent courses absolutely loosely, painlessly and bloodlessly. The mean time of follow-up was 27 months (one to four years. No complications were observed. Conclusion Sutureless prepuceplasty may present an acceptable alternative in children's phimosis reconstruction.

  18. Selection Methodology Approach to Preferable and Alternative Sites for the First NPP Project in Yemen

    International Nuclear Information System (INIS)

    The purpose of this paper is to briefly present the methodology and results of the first siting study for the first nuclear power plant (NPP) in Yemen. In this study it has been demonstrated that there are suitable sites for specific unit/units power of 1000 MWt (about 300 MWe) nuclear power plant. To perform the site selection, a systematic selection method was developed. The method uses site-specific data gathered by literature review and expert judgement to identify the most important site selection criteria. A two-step site selection process was used. Candidate sites were chosen that meet a subset of the selection criteria that form the most important system constraints. These candidate sites were then evaluated against the full set of selection criteria using the Analytical Hierarchy Process Method (AHP). Candidate sites underwent a set of more specific siting criteria weighted by expert judgment to select preferable sites and alternatives using AHP method again. Expert Judgment method was used to rank and weight the importance of each criteria, then AHP method used to evaluate and weight the relation between criterion to criterion and between all criteria against the global weight. Then logical decision software was used to rank sites upon their weighting value

  19. Advance commitment: an alternative approach to the family veto problem in organ procurement.

    Science.gov (United States)

    De Wispelaere, Jurgen; Stirton, Lindsay

    2010-03-01

    This article tackles the current deficit in the supply of cadaveric organs by addressing the family veto in organ donation. The authors believe that the family veto matters-ethically as well as practically-and that policies that completely disregard the views of the family in this decision are likely to be counterproductive. Instead, this paper proposes to engage directly with the most important reasons why families often object to the removal of the organs of a loved one who has signed up to the donor registry-notably a failure to understand fully and deliberate on the information and a reluctance to deal with this sort of decision at an emotionally distressing time. To accommodate these concerns it is proposed to separate radically the process of information, deliberation and agreement about the harvesting of a potential donor's organs from the event of death and bereavement through a scheme of advance commitment. This paper briefly sets out the proposal and discusses in some detail its design as well as what is believed to be the main advantages compared with the leading alternatives. PMID:20212000

  20. An alternative approach to compensators design for photon beams used in radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Jurkovic, S. [University Hospital, Department of Radiotherapy, Physics Division, Kresimirova 42, 51000 Rijeka (Croatia); Zauhar, G. [School of Medicine, Department of Physics, Brace Branchetta 20, 51000 Rijeka (Croatia)], E-mail: gordz@medri.hr; Bistrovic, M. [Hospital for Tumors, Radiotherapy Department, Ilica 272, 10000 Zagreb (Croatia); Faj, D. [University Hospital, Department of Radiotherapy and Oncology, J. Huttlera 4, 31000 Osijek (Croatia); Kaliman, Z. [Faculty of Sciences and Arts, Department of Physics, Omladinska 14, 51000 Rijeka (Croatia); Smilovic Radojcic, D. [University Hospital, Department of Radiotherapy, Physics Division, Kresimirova 42, 51000 Rijeka (Croatia)

    2007-09-21

    The use of compensators in order to achieve desired dose distribution has a long history and is a well-established technique in radiation therapy planning. There are several different calculation methods for determining a compensator's thickness. An alternative method that is based on the Cunningham's modification of Clarkson's method to calculate scattered radiation in beams with an inhomogeneous cross-section is proposed. It is well known that the total dose distribution of radiotherapy photon beam consists of the contributions of the primary beam, attenuated by the tissue layer, and the scattered radiation generated by the primary radiation in single and multiple photon scatter events. The scattered component can be represented as a function of the primary radiation. The central point of our method is the numerical estimation of the primary distribution required to achieve the desired total distribution. Now using the calculated primary distribution, the shape of the modulator could be determined. In this way the contribution of the scattered component is validated in a more accurate way than using effective attenuation coefficients, which is a common practice. The method is verified in various clinical situations and compared with the standard method. The accuracy, although dependent on geometry, was improved by at least 2%. With more complex geometries there is an even higher gain in accuracy with our method when compared to the standard method.

  1. Butterfly cartilage tympanoplasty: An alternative approach for management of small- and medium-sized perforations

    Directory of Open Access Journals (Sweden)

    Ashish Kumar Maurya

    2016-01-01

    Full Text Available Objective: To evaluate the efficacy of butterfly cartilage tympanoplasty for small- and medium-sized central perforations and compare it with temporalis fascia tympanoplasty. Materials and Methods: A prospective, comparative study was conducted on 110 patients, divided into two groups. Patients of tubotympanic type of chronic suppurative otitis media with 2–6 mm size perforation were included in the study. Fifty-five patients were operated by temporalis fascia Type I tympanoplasty and rest 55 by butterfly cartilage tympanoplasty (transcanal technique under local anesthesia. Results were compared in terms of pre- and post-operative air-bone gap improvement and success rates. Results: In our study, in terms of outcomes, both techniques had similar results. The success rate was 93.7% in butterfly cartilage tympanoplasty and 96.3% in temporalis fascia group. However, in terms of time taken, butterfly cartilage tympanoplasty took less time (about 30 min than temporalis fascia (about 55 min. Conclusion: Transcanal butterfly cartilage tympanoplasty is a very good alternative in small- and medium-sized perforations for conventional temporalis fascia tympanoplasty as it is simple, takes less time, day care procedure, on table hearing improvement, cosmetically no postoperative scar, no need of post aural preparation, and patient can go home within hours.

  2. Manual intrastromal corneal keratotomy: An alternate encouraging approach for refractive error correction

    Directory of Open Access Journals (Sweden)

    Saravana Kodandapani

    2014-01-01

    Full Text Available Results of femtosecond based intrastromal astigmatic keratotomy have been reported to be encouraging for correction of Astigmatism. We report a new surgical technique-manual intrastromal corneal keratotomy (MICK for correction of simple refractive astigmatism (−1.5 DC against the rule. The technique involves the creation of a 100 μm thickness corneal flap creation using Moria M2 evolution LSK MicroKeratome and 300 μm depth, 4 mm long manual transverse astigmatic keratotomy on both sides of the steep axis 3 mm from the pupillary center along with four incision peripheral radial keratotomy outside the optic zone (based on the mesopic pupil. The flap was repositioned and routine post-operative regimen was followed. Patient achieved 20/20 vision in both eyes post-operatively on the first day, which was maintained even at the 1 month follow-up. This simple technique could be useful as an alternative method for correction of refractive errors in patients not suitable for excimer and/or femtosecond laser treatment.

  3. Supercritical fluid extraction of meat lipids: an alternative approach to the identification of irradiated meats

    International Nuclear Information System (INIS)

    Ionizing radiation is currently under study as an alternative method for extending the shelf life of meats and meat products. Accordingly, methods are needed to determine if a meat or meat product has been exposed to ionizing radiation. In this study, a method is described for the isolation and analysis of volatile hydrocarbons formed in meat lipids after exposure to ionizing radiation. The method is based on supercritical fluid extraction of the hydrocarbons from meat lipids and subsequent identification and quantitation of individual hydrocarbons by gas chromatography (GC) with a mass selection detector (MSD). Supercritical carbon dioxide at 175 bar and 40°C extracted the hydrocarbon fraction from total meat lipids within 20 min. The presence of radiolytic hydrocarbons, as determined by GC/MSD, was then correlated to the degree of irradiation of the meat from 0 to 10 kGy. Besides being faster, this method has the advantage of reduced solvent consumption when compared to current methods for determining if a meat or meat product has been irradiated

  4. Debt Shifting and Thin-Capitalization Rules – German Experience and Alternative Approaches

    Directory of Open Access Journals (Sweden)

    Ruf Martin

    2015-09-01

    Full Text Available This paper presents the general design of thin-capitalization rules and summarizes the economic effects of such rules as identified in theoretical models. We review empirical studies providing evidence on the experience with (German thin-capitalization rules as well as on the adjustment of German multinationals to foreign thin-capitalization rules. Special emphasis is given to the development in Germany, because Germany went a long way in limiting interest deductibility by enacting a drastic change in its thin-capitalization rules in 2008, and because superb German data on multinational finance allows for testing several aspects consistently. We then discuss the experience of the Nordic countries with thin-capitalization rules. Briefly reviewing potential alternatives as well, we believe that the arm’s-length principle is administratively too costly and impracticable, whereas we argue that controlled-foreign-company rules might be another promising avenue for limiting internal debt shifting. Fundamental tax reforms towards a system with either "allowance for corporate equity" (ACE or a "comprehensive business income tax" (CBIT should also eliminate any thin-capitalization incentive.

  5. Selection Methodology Approach to Preferable and Alternative Sites for the First NPP Project in Yemen

    Energy Technology Data Exchange (ETDEWEB)

    Kassim, Moath [Kyunghe Univ., Yongin (Korea, Republic of); Kessel, David S. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2015-05-15

    The purpose of this paper is to briefly present the methodology and results of the first siting study for the first nuclear power plant (NPP) in Yemen. In this study it has been demonstrated that there are suitable sites for specific unit/units power of 1000 MWt (about 300 MWe) nuclear power plant. To perform the site selection, a systematic selection method was developed. The method uses site-specific data gathered by literature review and expert judgement to identify the most important site selection criteria. A two-step site selection process was used. Candidate sites were chosen that meet a subset of the selection criteria that form the most important system constraints. These candidate sites were then evaluated against the full set of selection criteria using the Analytical Hierarchy Process Method (AHP). Candidate sites underwent a set of more specific siting criteria weighted by expert judgment to select preferable sites and alternatives using AHP method again. Expert Judgment method was used to rank and weight the importance of each criteria, then AHP method used to evaluate and weight the relation between criterion to criterion and between all criteria against the global weight. Then logical decision software was used to rank sites upon their weighting value.

  6. Mathematical comparison between volume of distribution (V) and volume of distribution at steady-state (Vss) utilizing model-independent approach.

    Science.gov (United States)

    Sobol, Eyal; Bialer, Meir

    2004-03-01

    Pharmacokinetic textbooks state that the (apparent) volume of distribution based on drug concentration in plasma (V or Vbeta) is always greater than the volume of distribution (apparent) under steady state conditions (Vss), but do not provide a general model-independent mathematical proof. Wagner's mathematical comparison between Vbeta and Vss is based on microscopic rate constants of either specific models and is restricted solely to the two-compartment open body model. Nakashima and Benet utilizing a model-dependent approach showed a mathematical relationship between Vbeta and Vss for a multicompartment model, but again by using microscopic model constants. The limitation of these two above mentioned mathematical comparisons is the necessity of knowledge of the model's structure and its microscopic rate constants. The present article describes a new non-compartmental, model-independent, general mathematical proof for Vbeta to be always greater than Vss. This new method does not require any knowledge of microscopical rate constants and is based solely on an exponentially decreasing function, which is the common way to describe drug disposition following i.v. bolus. PMID:14872558

  7. An Alternative and Efficient Cluster-Link Approach for Declustering of Earthquake Catalogs

    Science.gov (United States)

    Tibi, R.; Blanco, J.; Fatehi, A.

    2011-12-01

    Poisson model is widely used to describe the temporal occurrence of earthquakes in probabilistic seismic hazard analysis (PSHA) studies for various reasons. The most important of these is that Poisson model is simple, yet adequate enough to describe a complex phenomenon. Studies of temporal earthquake distribution show that earthquake sequences are Poissonian only after foreshocks and aftershocks have been removed from the listing. Hence, the identification and removal of foreshocks and aftershocks from earthquake catalogs, a process referred to as declustering, are a prerequisite for any PSHA study based on a Poissonian model for earthquake occurrence. Two main approaches and their variants are widely used in the seismic hazard assessment community for catalog declustering: (1) the standard space-time windowing technique, such as Gardner and Knopoff (1974) method, and (2) the cluster-link scheme, such as Reasenberg (1985) algorithm or Davis and Frohlich (1991) method. Each of these methods possesses some advantages as well as shortcomings. We propose a cluster-link declustering approach that is adapted from Reasenberg's (1985) technique, in which the interaction time window based on Poisson's probability is replaced by a simple, but more efficient magnitude-dependent time criterion. Application of the proposed scheme to earthquake catalogs of Slovenia and the Middle East suggests that, depending on the character of the original catalog in terms of event sizes, the proposed approach identifies up to13% more dependent events, more efficiently depletes or removes clusters of earthquakes, and, as consequence, dramatically improves the fit to the expected Poisson model, with respect to Reasenberg's (1985) method.

  8. Alternative policy impacts on US GHG emissions and energy security: A hybrid modeling approach

    International Nuclear Information System (INIS)

    This study addresses the possible impacts of energy and climate policies, namely corporate average fleet efficiency (CAFE) standard, renewable fuel standard (RFS) and clean energy standard (CES), and an economy wide equivalent carbon tax on GHG emissions in the US to the year 2045. Bottom–up and top–down modeling approaches find widespread use in energy economic modeling and policy analysis, in which they differ mainly with respect to the emphasis placed on technology of the energy system and/or the comprehensiveness of endogenous market adjustments. For this study, we use a hybrid energy modeling approach, MARKAL–Macro, that combines the characteristics of two divergent approaches, in order to investigate and quantify the cost of climate policies for the US and an equivalent carbon tax. The approach incorporates Macro-economic feedbacks through a single sector neoclassical growth model while maintaining sectoral and technological detail of the bottom–up optimization framework with endogenous aggregated energy demand. Our analysis is done for two important objectives of the US energy policy: GHG reduction and increased energy security. Our results suggest that the emission tax achieves results quite similar to the CES policy but very different results in the transportation sector. The CAFE standard and RFS are more expensive than a carbon tax for emission reductions. However, the CAFE standard and RFS are much more efficient at achieving crude oil import reductions. The GDP losses are 2.0% and 1.2% relative to the base case for the policy case and carbon tax. That difference may be perceived as being small given the increased energy security gained from the CAFE and RFS policy measures and the uncertainty inherent in this type of analysis. - Highlights: • Evaluates US impacts of three energy/climate policies and a carbon tax (CT) • Analysis done with bottom–up MARKAL model coupled with a macro model • Electricity clean energy standard very close to

  9. Alternative Approaches to Estimating the Linear Propagator and Finite-Time Growth Rates from Data

    Directory of Open Access Journals (Sweden)

    Yung-An Lee and Zih-Ting Hung

    2009-01-01

    Full Text Available The propagator of a linear model plays a central role in empirical no mal mode and finite-time instability problems. Its estimation will affect whether the linear stability character is tics of the corresponding dynamic system can be properly extracted. In this study, we introduce two alternative methods for estimating the linear propagator and finite-time growth rates from data. The first is the generalized singular value de composition (GSVD and the second is the singular value de composition combined with the cosine-sine decomposition (SVD-CSD. Both methods linearize the relation between the predictor and the predict and by de composing them to have a common evolution structure and then make the estimations. Thus, the linear propagator and the associated singular vectors can be simultaneously derived. The GSVD clearly reveals the connection between the finite-time amplitude growth rates and the singular values of the propagator. However, it can only be applied in situations when given data have more state variables than observations. Further more, it generally encounters an over-fit ting problem when data are contaminated by noise. To fix these two draw backs, the GSVD is generalized to the SVD-CSD to include data filtering capability. There fore, it has more flexibility in dealing with general data situations. These two methods as well as the Yule-Walker equation were applied to two synthetic datasets and the _ sea surface temperature anomalies (SSTA to evaluate their performance. The results show that, be cause of linearization and flexible filtering capabilities, the propagator and its associated properties could be more accurately estimated with the SVD-CSD than other methods.

  10. Alternative theoretical and methodological approaches for exploring higher education in Art and Crafts

    Directory of Open Access Journals (Sweden)

    Marte Sørebø Gulliksen

    2009-12-01

    Full Text Available This article presents and discusses approaches for exploring higher education in Art and Crafts. The concepts exploring versus research and the different foci in an insider perspective versus an outsider perspective introduces the theme. An insider perspective is said to be a useful starting point for inquiry, referring to Frayling’s trichotomy research into, research on and research through from 1993. The field of higher education in Art and Crafts education is shortly presented as comprising two main areas of knowledge: knowledge of education, and knowledge about the different subject areas within Art and Crafts. Both theory and practice are a part of these areas of knowledge. As higher education in Art and Crafts is a making profession, the most prominent challenge when exploring this today is thus said to be to develop research based knowledge on Education in Art and Crafts as a making discipline.  Two keywords are deemed to be useful in approaching this theme: Mode 2 knowledge production and transdisciplinarity. The article concludes with describing specific ways of doing this today from within the context of application. Two examples of large research projects in Scandinavia are presented as examples of such projects.

  11. A new insight into interfaces of immiscible binary polymer blends from the free volume approach

    Science.gov (United States)

    Ramya, P.; Meghala, D.; Pasang, T.; Raj, J. M.; Chandrashekara, M. N.; Ranganathaiah, C.

    2012-06-01

    The interface width in an immiscible (PVC/PS) polymer blend is determined using hydrodynamic interaction parameter (α) derived from free volume data measured using Positron lifetime spectrometer. CONTIN program has been employed to get the free volume hole size distribution. A new definition of interface width is presented, which originates from the Kirkwood-Riseman theory and friction coefficient as per Stokes equation. Friction at the interface of a binary blend decides how close the surfaces come or stay farther resulting in narrow or broad interface width respectively.

  12. Equilibrium energy spread and emittance in a Compton ring: An alternative approach

    Science.gov (United States)

    Chaikovska, I.; Variola, A.

    2014-04-01

    In this article the Campbell's theorem is used to evaluate the equilibrium emittance and energy spread in a Compton ring. This method allows us to have an efficient analytical approach separating the contributions of the Compton cross section from the luminosity factor. The consequent advantage is given by the possibility to have an easy extrapolation for the "nonclassical" cases like the polarized Compton backscattering or the evaluation of the equilibrium given by different radiation mechanisms. The effects accounting for the polarized Compton backscattering in the article are evaluated numerically. The analytical results in the nonpolarized case and in the negligible recoil effect approximation are in excellent agreement with the values obtained by matching the Compton damping rate with the quantum fluctuations, and they show that the equilibrium energy spread and emittance are independent from the luminosity.

  13. Permeability estimation for heavy oil reservoir: an alternative approach to avoid misleading tendencies

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, L. [PDVSA (Venezuela)

    2011-07-01

    In oil production, characterization of the reservoir has to be undertaken in order to optimize the hydrocarbon production rate. Permeability is one of the most important parameters of a reservoir but estimation is difficult in heavy oil reservoirs and requires the use of multiple techniques. The objective of this paper was to evaluate the results of implementing a multi-scale permeability estimation method. Scale support effect and the physics of the measurements were looked into through a study which was conducted in Venezuela on two of PDVSA's fields, the Cerro Negro Field and the Morichal Field. Results showed that the proposed methodology captured efficiently the influence of parameters on permeability production and was successful in removing the local bias from the permeability data. The multi scale permeability estimation methodology was shown to address the issues encountered with a unique approach and to provide excellent results.

  14. FORECASTING CHINA'S FOREIGN TRADE VOLUME WITH A KERNEL-BASED HYBRID EC-ONOMETRIC-AI ENSEMBLE LEARNING APPROACH

    Institute of Scientific and Technical Information of China (English)

    Lean YU; Shouyang WANG; Kin Keung LAI

    2008-01-01

    Due to the complexity of economic system and the interactive effects between all kinds of economic variables and foreign trade, it is not easy to predict foreign trade volume. However, the difficulty in predicting foreign trade volume is usually attributed to the limitation of many conventional forecasting models. To improve the prediction performance, the study proposes a novel kernel-based ensemble learning approach hybridizing econometric models and artificial intelligence (AI) models to predict China's foreign trade volume. In the proposed approach, an important econometric model, the co-integration-based error correction vector auto-regression (EC-VAR) model is first used to capture the impacts of all kinds of economic variables on Chinese foreign trade from a multivariate linear anal-ysis perspective. Then an artificial neural network (ANN) based EC-VAR model is used to capture the nonlinear effects of economic variables on foreign trade from the nonlinear viewpoint. Subsequently, for incorporating the effects of irregular events on foreign trade, the text mining and expert's judgmental adjustments are also integrated into the nonlinear ANN-based EC-VAR model. Finally, all kinds of economic variables, the outputs of linear and nonlinear EC-VAR models and judgmental adjustment model are used as input variables of a typical kernel-based support vector regression (SVR) for en-semble prediction purpose. For illustration, the proposed kernel-based ensemble learning methodology hybridizing econometric techniques and AI methods is applied to China's foreign trade volume predic-tion problem. Experimental results reveal that the hybrid econometric-AI ensemble learning approach can significantly improve the prediction performance over other linear and nonlinear models listed in this study.

  15. A Vector Approach to Euclidean Geometry: Vector Spaces and Affine Geometry, Volume 1. Teacher's Edition.

    Science.gov (United States)

    Vaughan, Herbert E.; Szabo, Steven

    This is the teacher's edition of a text for the first year of a two-year high school geometry course. The course bases plane and solid geometry and trigonometry on the fact that the translations of a Euclidean space constitute a vector space which has an inner product. Volume 1 deals largely with affine geometry, and the notion of dimension is…

  16. New Approach to Purging Monitoring Wells: Lower Flow Rates Reduce Required Purging Volumes and Sample Turbidity

    Science.gov (United States)

    It is generally accepted that monitoring wells must be purged to access formation water to obtain “representative” ground water quality samples. Historically anywhere from 3 to 5 well casing volumes have been removed prior to sample collection to evacuate the standing well water...

  17. A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change

    International Nuclear Information System (INIS)

    An analytical approach to predict respiratory diaphragm motion should have advantages over a correlation-based method, which cannot adapt to breathing pattern changes without re-calibration for a changing correlation and/or linear coefficient. To quantitatively calculate the diaphragm motion, a new expandable 'piston' respiratory (EPR) model was proposed and tested using 4DCT torso images of 14 patients. The EPR model allows two orthogonal lung motions (with a few volumetric constraints): (1) the lungs expand (ΔVEXP) with the same anterior height variation as the thoracic surface, and (2) the lungs extend (ΔVEXT) with the same inferior distance as the volumetrically equivalent 'piston' diaphragm. A volume conservation rule (VCR) established previously (Li et al 2009 Phys. Med. Biol. 54 1963-78) was applied to link the external torso volume change (TVC) to internal lung volume change (LVC) via lung air volume change (AVC). As the diaphragm moves inferiorly, the vacant space above the diaphragm inside the rib cage should be filled by lung tissue with a volume equal to ΔVEXT (=LVC-ΔVEXP), while the volume of non-lung tissues in the thoracic cavity should conserve. It was found that ΔVEXP accounted for 3-24% of the LVC in these patients. The volumetric shape of the rib cage, characterized by the variation of cavity volume per slice over the piston motion range, deviated from a hollow cylinder by -1.1% to 6.0%, and correction was made iteratively if the variation is >3%. The predictions based on the LVC and TVC (with a conversion factor) were compared with measured diaphragm displacements (averaged from six pivot points), showing excellent agreements (0.2 ± 0.7 mm and 0.2 ± 1.2 mm, respectively), which are within clinically acceptable tolerance. Assuming motion synchronization between the piston and points of interest along the diaphragm, point motion was estimated but at higher uncertainty (∼10% ± 4%). This analytical approach provides a patient

  18. A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change

    Energy Technology Data Exchange (ETDEWEB)

    Li Guang; Xie Huchen; Ning Holly; Citrin, Deborah; Kaushal, Aradhana; Zach, Leor; Camphausen, Kevin; Miller, Robert W [Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 (United States); Lu Wei; Low, Daniel [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110 (United States)], E-mail: ligeorge@mail.nih.gov

    2009-07-07

    An analytical approach to predict respiratory diaphragm motion should have advantages over a correlation-based method, which cannot adapt to breathing pattern changes without re-calibration for a changing correlation and/or linear coefficient. To quantitatively calculate the diaphragm motion, a new expandable 'piston' respiratory (EPR) model was proposed and tested using 4DCT torso images of 14 patients. The EPR model allows two orthogonal lung motions (with a few volumetric constraints): (1) the lungs expand ({delta}V{sub EXP}) with the same anterior height variation as the thoracic surface, and (2) the lungs extend ({delta}V{sub EXT}) with the same inferior distance as the volumetrically equivalent 'piston' diaphragm. A volume conservation rule (VCR) established previously (Li et al 2009 Phys. Med. Biol. 54 1963-78) was applied to link the external torso volume change (TVC) to internal lung volume change (LVC) via lung air volume change (AVC). As the diaphragm moves inferiorly, the vacant space above the diaphragm inside the rib cage should be filled by lung tissue with a volume equal to {delta}V{sub EXT} (=LVC-{delta}V{sub EXP}), while the volume of non-lung tissues in the thoracic cavity should conserve. It was found that {delta}V{sub EXP} accounted for 3-24% of the LVC in these patients. The volumetric shape of the rib cage, characterized by the variation of cavity volume per slice over the piston motion range, deviated from a hollow cylinder by -1.1% to 6.0%, and correction was made iteratively if the variation is >3%. The predictions based on the LVC and TVC (with a conversion factor) were compared with measured diaphragm displacements (averaged from six pivot points), showing excellent agreements (0.2 {+-} 0.7 mm and 0.2 {+-} 1.2 mm, respectively), which are within clinically acceptable tolerance. Assuming motion synchronization between the piston and points of interest along the diaphragm, point motion was estimated but at higher

  19. An alternative approach to analyze Ipsative data. Revisiting Experiential Learning Theory

    Directory of Open Access Journals (Sweden)

    Joan Manuel eBatista-Foguet

    2015-11-01

    Full Text Available The ritualistic use of statistical models regardless of the type of data actually available is a common practice across disciplines. Statistical models involve a series of assumptions whose existence is often neglected altogether, thus making the mentioned common practice even more pervasive. This paper illustrates the consequences of this ritualistic practice within Kolb’s Experiential Learning Theory (ELT operationalized through its Learning Style Inventory (KLSI. We show how using a well-known methodology in other disciplines -compositional data analysis (CODA- KLSI data can be properly analyzed. In addition, a third dimension of the KLSI is unveiled providing room for future research. This third dimension describes an individual’s relative preference for learning by prehension rather than by transformation. Using a sample of European MBA students, we relate this dimension with another self-assessment instrument, the Philosophical Orientation Questionnaire (POQ, and with an observer-assessed instrument, the Emotional and Social Inventory (ESCI-U. Both show plausible statistical relationships. An intellectual operating philosophy is linked to a preference for prehension, whereas a pragmatic operating philosophy is linked to transformation. Self-management and social awareness competencies are linked to a learning preference for transforming knowledge, whereas relationship management and cognitive competencies are more related to approaching learning by prehension.

  20. Education and microfinance: an alternative approach to the empowerment of the poor people in Indonesia.

    Science.gov (United States)

    Hadi, Rizali; Wahyudin, Uyu; Ardiwinata, Jajat S; Abdu, Wamaungo Juma

    2015-01-01

    There is good reason to combine education with microcredit for poverty alleviation in the poor communities of the developing world, including in Indonesia. Poverty is dangerous, it deprives people of their right to education, their right to good health, their right to freedom of speech, their right to democracy, their right to financial services and of course their right to knowledge enhancement, which are all crucial to living a better life. We must therefore, provide services beyond, credits for the poor. In this case, education should be included to each and every development agenda for the poor since it is key to any positive change and sustainable development of people. If well planned and well integrated within the microcredit services, education can serve a good purpose in poverty alleviation. This paper describes how education and microfinance have been used in combination to alleviate poverty in Indonesia, especially in the areas studied. The study uses a multi-cases approach to examine the purposively selected baitul maal tamwil (BMTs) organisations, which are sharia based semiformal microfinance institutions regarded to be among those few integrating education with their financial services. PMID:26085974

  1. Bioacoustics of human whistled languages: an alternative approach to the cognitive processes of language

    Directory of Open Access Journals (Sweden)

    Meyer Julien

    2004-01-01

    Full Text Available Whistled languages are a valuable heritage of human culture. This paper gives a first survey about a new multidisciplinary approach to these languages. Previous studies on whistled equivalents of languages have already documented that they can provide significant information about the role of rhythm and melody in language. To substantiate this, most whistles are represented by modulations of frequency, centered around 2000 Hz (±1000 Hz and often reach a loudness of about 130 dB (measured at 1m from the source. Their transmission range can reach up to 10 km (as verified in La Gomera, Canary Island, and the messages can remain understandable, even if the signal is deteriorated. In some cultures the use of whistled language is associated with some "talking musical instruments" (e.g. flutes, guitars, harps, gongs, drums, khens. Finally, whistles as a means of conveying information have some analogues in the animal kingdom (e.g. some birds, cetaceans, primates, providing opportunities to compare the acoustic characteristics of the respective signals. With such properties as a reference, the project reported here has two major tasks: to further elucidate the many facets of whistled language and, above all, help to immediately stop the process of its gradual disappearance.

  2. Murine fundus fluorescein angiography: An alternative approach using a handheld camera.

    Science.gov (United States)

    Ehrenberg, Moshe; Ehrenberg, Scott; Schwob, Ouri; Benny, Ofra

    2016-07-01

    In today's modern pharmacologic approach to treating sight-threatening retinal vascular disorders, there is an increasing demand for a compact, mobile, lightweight and cost-effective fluorescein fundus camera to document the effects of antiangiogenic drugs on laser-induced choroidal neovascularization (CNV) in mice and other experimental animals. We have adapted the use of the Kowa Genesis Df Camera to perform Fundus Fluorescein Angiography (FFA) in mice. The 1 kg, 28 cm high camera has built-in barrier and exciter filters to allow digital FFA recording to a Compact Flash memory card. Furthermore, this handheld unit has a steady Indirect Lens Holder that firmly attaches to the main unit, that securely holds a 90 diopter lens in position, in order to facilitate appropriate focus and stability, for photographing the delicate central murine fundus. This easily portable fundus fluorescein camera can effectively record exceptional central retinal vascular detail in murine laser-induced CNV, while readily allowing the investigator to adjust the camera's position according to the variable head and eye movements that can randomly occur while the mouse is optimally anesthetized. This movable image recording device, with efficiencies of space, time, cost, energy and personnel, has enabled us to accurately document the alterations in the central choroidal and retinal vasculature following induction of CNV, implemented by argon-green laser photocoagulation and disruption of Bruch's Membrane, in the experimental murine model of exudative macular degeneration. PMID:27260483

  3. Alternate approach to inertial confinement fusion with low tritium inventories and high power densities

    International Nuclear Information System (INIS)

    A low-tritium-inventory, high-power-density, pool-type chamber approach to inertial confinement fusion is introduced. The concept uses target designs with internal tritiumand 3He breeding, eliminating the need for a lithium-breeding blanket. The fraction of the fusion energy carried out by neutrons is estimated as 10%, compared with 70% in a typical D-T system, and the neutron spectrum is softer. Liquid metals other than lithium that are less chemically reactive, such as lead, can be used for first-wall protection. The reduced neutron component and the elimination of the need for a thick lithium blanket for tritium breeding lead to higher power densities and more compact chamber designs. The radiation damage at the first structural wall is reduced, leading to potentially longer wall lifetimes. A significant environmental advantage in terms of reduced radioactive release risks under operational and accident conditions is identified, primarily due to the one to two orders of magnitude reduction in the tritium inventories compared with D-T-based systems

  4. Alternative approaches to the definition and identification of learning disabilities: some questions and answers.

    Science.gov (United States)

    Fletcher, Jack M; Coulter, W Alan; Reschly, Daniel J; Vaughn, Sharon

    2004-12-01

    Recent consensus reports concur in suggesting major changes in the federal regulatory approach to the identification of learning disabilities (LD). These reports recommend abandoning the IQ-discrepancy model and the use of IQ tests for identification, and also recommend incorporation of response to instruction (RTI) as one of the identification criteria. These changes are also recommended to states in the current reauthorization of the U.S. Individuals with Disabilities in Education Act (IDEA). While not mandatory, states that follow these recommendations will experience major changes in identification and treatment of students served under the LD category. This paper reviews the basis for these recommendations, summarizing four recent consensus group reports on special education that concur in suggesting these changes. Seventeen commonly asked questions about these changes are presented, with responses. In order to ensure adequate instruction for students with LD, it is essential that identification practices focus on assessments that are directly related to instruction, that any services for students who are struggling prioritize intervention over eligibility, and that special education be permitted to focus more on results and outcomes and less on eligibility and process. Identification models that incorporate RTI represent a shift in special education toward the goals of better achievement and behavioral outcomes for students identified with LD, as well as those students at risk for LD. PMID:15741940

  5. Alternative Modelling Approach to Spatial Harvest Scheduling with Respect to Fragmentation of Forest Ecosystem

    Science.gov (United States)

    Marušák, Róbert; Kašpar, Jan; Hlavatý, Robert; Kotek, Václav; Kuželka, Karel; Vopěnka, Petr

    2015-11-01

    Fragmentation of the forests affects forest ecosystems by changing the composition, shape, and configuration of the resulting patches. Subsequently, the prevailing conditions vary between patches. The exposure to the sun decreases from the patch boundary to the patch interior and this forms core and edge areas within each patch. Forest harvesting and, in particular, the clear-cut management system which is still preferred in many European countries has a significant impact on forest fragmentation. There are many indices of measuring fragmentation: non-spatial and spatial. The non-spatial indices measure the composition of patches, while the spatial indices measure both the shape and configuration of the resulting patches. The effect of forest harvesting on fragmentation, biodiversity, and the environment is extensively studied; however, the integration of fragmentation indices in the harvest scheduling model is a new, novel approach. This paper presents a multi-objective integer model of harvest scheduling for clear-cut management system and presents a case study demonstrating its use. Harvest balance and sustainability are ensured by the addition of constraints from the basic principle of the regulated forest model. The results indicate that harvest balance and sustainability can be also achieved in minimizing fragmentation of forest ecosystems. From the analyses presented in this study, it can be concluded that integration of fragmentation into harvest scheduling can provide better spatial structure. It depends on the initial spatial and age structure. It was confirmed that it is possible to find compromise solution while minimizing fragmentation and maximizing harvested area.

  6. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation.

    Science.gov (United States)

    Langdon, Amy; Crook, Nathan; Dantas, Gautam

    2016-01-01

    The widespread use of antibiotics in the past 80 years has saved millions of human lives, facilitated technological progress and killed incalculable numbers of microbes, both pathogenic and commensal. Human-associated microbes perform an array of important functions, and we are now just beginning to understand the ways in which antibiotics have reshaped their ecology and the functional consequences of these changes. Mounting evidence shows that antibiotics influence the function of the immune system, our ability to resist infection, and our capacity for processing food. Therefore, it is now more important than ever to revisit how we use antibiotics. This review summarizes current research on the short-term and long-term consequences of antibiotic use on the human microbiome, from early life to adulthood, and its effect on diseases such as malnutrition, obesity, diabetes, and Clostridium difficile infection. Motivated by the consequences of inappropriate antibiotic use, we explore recent progress in the development of antivirulence approaches for resisting infection while minimizing resistance to therapy. We close the article by discussing probiotics and fecal microbiota transplants, which promise to restore the microbiota after damage of the microbiome. Together, the results of studies in this field emphasize the importance of developing a mechanistic understanding of gut ecology to enable the development of new therapeutic strategies and to rationally limit the use of antibiotic compounds. PMID:27074706

  7. Reflection on the possibility of alternative approach to the psychopathology of “functional” disorders

    Directory of Open Access Journals (Sweden)

    Jerzy W. Aleksandrowicz

    2016-05-01

    Full Text Available Functional short-term disorders provoked by extremely difficult life events – stresses – are entirely different from the chronic or recurrent ones: anxiety or other “neurotic” syndromes, eating, sexual and some other disorders, not being conditioned behavioral dysfunctions. Chronic/ recurrent disorders seems to have they causes in the particular personality traits and deficits. Some of them are revealed, described and could be measured by means of Neurotic Personality Questionnaire KON 2006. In this approach, functional disorder is understood as structured systems of the particular nonverbal language (“parole” in which symptoms play a role of words while syndromes the role of sentences, expressing the current state of mind – mainly the need of bond with other people and its frustration. They are messages of looking attention, attachment. The use of such language seems to be the result of personality deficits making difficult or even impossible to fulfil the need of bond in the psychosocial field using common for done culture verbal and nonverbal language, “normal” means of communication. While in the acute and conditioned reactions on stress different forms of helping people (e.g. CBT seems to be adequate, in the chronic and recurrent functional disorders therapy is postulated to aiming rather at transformations of the communication, leading to the exchange of the messages’ language having the quality of disorder for common, mainly verbal one.

  8. Evaluation of a Novel Approach for Automatic Volume Determination of Glioblastomas Based on Several Manual Expert Segmentations

    CERN Document Server

    Egger, Jan; Kuhnt, Daniela; Carl, Barbara; Kappus, Christoph; Freisleben, Bernd; Nimsky, Christopher

    2011-01-01

    The glioblastoma multiforme is the most common malignant primary brain tumor and is one of the highest malignant human neoplasms. During the course of disease, the evaluation of tumor volume is an essential part of the clinical follow-up. However, manual segmentation for acquisition of tumor volume is a time-consuming process. In this paper, a new approach for the automatic segmentation and volume determination of glioblastomas (glioblastoma multiforme) is presented and evaluated. The approach uses a user-defined seed point inside the glioma to set up a directed 3D graph. The nodes of the graph are obtained by sampling along rays that are sent through the surface points of a polyhedron. After the graph has been constructed, the minimal s-t cut is calculated to separate the glioblastoma from the background. For evaluation, 12 Magnetic Resonance Imaging (MRI) data sets were manually segmented slice by slice, by neurosurgeons with several years of experience in the resection of gliomas. Afterwards, the manual se...

  9. Late-life brain volume: a life-course approach. The AGES-Reykjavik study.

    Science.gov (United States)

    Muller, Majon; Sigurdsson, Sigurdur; Kjartansson, Olafur; Gunnarsdottir, Ingibjorg; Thorsdottir, Inga; Harris, Tamara B; van Buchem, Mark; Gudnason, Vilmundur; Launer, Lenore J

    2016-05-01

    The "fetal-origins-of-adult-disease" hypothesis proposes that an unfavorable intrauterine environment, estimated from small birth size, may induce permanent changes in fetal organs, including the brain. These changes in combination with effects of (cardiovascular) exposures during adult life may condition the later risk of brain atrophy. We investigated the combined effect of small birth size and mid-life cardiovascular risk on late-life brain volumes. Archived birth records of weight and height were abstracted for 1348 participants of the age, gene/environment susceptibility-Reykjavik study (RS; 2002-2006) population-based cohort, who participated in the original cohort of the RS (baseline 1967). Mid-life cardiovascular risk factors (CVRF) were collected in the RS. As a part of the late-life age, gene/environment susceptibility-RS examination, a brain magnetic resonance imaging was acquired and from it, volumes of total brain, gray matter, white matter, and white matter lesions were estimated. Adjusting for intracranial volume, demographics, and education showed small birth size (low ponderal index [PI]) and increased mid-life cardiovascular risk had an additive effect on having smaller late-life brain volumes. Compared with the reference group (high PI/absence of mid-life CVRF), participants with lower PI/presence of mid-life CVRF (body mass index >25 kg/m(2), hypertension, diabetes, "ever smokers") had smaller total brain volume later in life; B (95% confidence interval) were -10.9 mL (-21.0 to -0.9), -10.9 mL (-20.4 to -1.4), -20.9 mL (-46.9 to 5.2), and -10.8 mL (-19.3 to -2.2), respectively. These results suggest that exposure to an unfavorable intrauterine environment contributes to the trajectory toward smaller brain volume, adding to the atrophy that may be associated with mid-life cardiovascular risk. PMID:27103521

  10. Accounting for water management issues within hydrological simulation: Alternative modelling options and a network optimization approach

    Science.gov (United States)

    Efstratiadis, Andreas; Nalbantis, Ioannis; Rozos, Evangelos; Koutsoyiannis, Demetris

    2010-05-01

    In mixed natural and artificialized river basins, many complexities arise due to anthropogenic interventions in the hydrological cycle, including abstractions from surface water bodies, groundwater pumping or recharge and water returns through drainage systems. Typical engineering approaches adopt a multi-stage modelling procedure, with the aim to handle the complexity of process interactions and the lack of measured abstractions. In such context, the entire hydrosystem is separated into natural and artificial sub-systems or components; the natural ones are modelled individually, and their predictions (i.e. hydrological fluxes) are transferred to the artificial components as inputs to a water management scheme. To account for the interactions between the various components, an iterative procedure is essential, whereby the outputs of the artificial sub-systems (i.e. abstractions) become inputs to the natural ones. However, this strategy suffers from multiple shortcomings, since it presupposes that pure natural sub-systems can be located and that sufficient information is available for each sub-system modelled, including suitable, i.e. "unmodified", data for calibrating the hydrological component. In addition, implementing such strategy is ineffective when the entire scheme runs in stochastic simulation mode. To cope with the above drawbacks, we developed a generalized modelling framework, following a network optimization approach. This originates from the graph theory, which has been successfully implemented within some advanced computer packages for water resource systems analysis. The user formulates a unified system which is comprised of the hydrographical network and the typical components of a water management network (aqueducts, pumps, junctions, demand nodes etc.). Input data for the later include hydraulic properties, constraints, targets, priorities and operation costs. The real-world system is described through a conceptual graph, whose dummy properties

  11. Testing of low-temperature stabilization alternatives for salt containing mixed wastes - Approach and results to date

    International Nuclear Information System (INIS)

    Through its annual process of identifying technology deficiencies associated with waste treatment, the Department of Energy's (DOE) Mixed Waste Focus Area (MWFA) determined that the former DOE weapons complex lacks efficient mixed waste stabilization technologies for salt containing wastes. These wastes were generated as sludge and solid effluents from various primary nuclear processes involving acids and metal finishing; and well over 10,000 cubic meters exist at 6 sites. In addition, future volumes of these problematic wastes will be produced as other mixed waste treatment methods such as incineration and melting are deployed. The current method used to stabilize salt waste for compliant disposal is grouting with Portland cement. This method is inefficient since the highly soluble and reactive chloride, nitrate, and sulfate salts interfere with the hydration and setting processes associated with grouting. The inefficiency results from having to use low waste loadings to ensure a durable and leach resistant final waste form. The following five alternatives were selected for MWFA development funding in FY97 and FY98: phosphate bonded ceramics; sol-gel process; polysiloxane; polyester resin; and enhanced concrete. Comparable evaluations were planned for the stabilization development efforts. Under these evaluations each technology stabilized the same type of salt waste surrogates. Final waste form performance data such as compressive strength, waste loading, and leachability could then be equally compared. Selected preliminary test results are provided in this paper

  12. Constrained reaction volume approach for studying chemical kinetics behind reflected shock waves

    KAUST Repository

    Hanson, Ronald K.

    2013-09-01

    We report a constrained-reaction-volume strategy for conducting kinetics experiments behind reflected shock waves, achieved in the present work by staged filling in a shock tube. Using hydrogen-oxygen ignition experiments as an example, we demonstrate that this strategy eliminates the possibility of non-localized (remote) ignition in shock tubes. Furthermore, we show that this same strategy can also effectively eliminate or minimize pressure changes due to combustion heat release, thereby enabling quantitative modeling of the kinetics throughout the combustion event using a simple assumption of specified pressure and enthalpy. We measure temperature and OH radical time-histories during ethylene-oxygen combustion behind reflected shock waves in a constrained reaction volume and verify that the results can be accurately modeled using a detailed mechanism and a specified pressure and enthalpy constraint. © 2013 The Combustion Institute.

  13. A practical approach to volume minimisation of low level radioactive waste at UKAEA, Winfrith

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, A.; Hawkins, G.; Milverton, P. [UKAEA, Solid Waste Services Section, Winfrith Technology Centre, Dorchester, Dorset (United Kingdom)

    2003-07-01

    To fulfil the United Kingdom Atomic Energy Authority (UKAEA) policy on best practicable environmental option (BPEO), the requirements of the radioactive substances act (RSA) 1993 and to meet the BNFL Drigg Conditions of Acceptance, the UKAEA Winfrith employ a range of techniques to minimise the volume of low level radioactive waste (LLW) consigned to BNFL drigg for final disposal. To achieve this the UKAEA Winfrith solid waste services section commissioned a plasma cutting facility, a lead decontamination facility and the Winfrith abrasive cleaning machine (WACM). These techniques coupled with regular supercompaction campaigns and a free release procedure ensure UKAEA Winfrith minimise the volume of LLW consigned to BNFL Drigg. This paper describes the waste minimisation techniques, the supercompaction campaigns and the free release monitoring programme employed at UKAEA Winfrith. (orig.)

  14. A practical approach to volume minimisation of low level radioactive waste at UKAEA, Winfrith

    International Nuclear Information System (INIS)

    To fulfil the United Kingdom Atomic Energy Authority (UKAEA) policy on best practicable environmental option (BPEO), the requirements of the radioactive substances act (RSA) 1993 and to meet the BNFL Drigg Conditions of Acceptance, the UKAEA Winfrith employ a range of techniques to minimise the volume of low level radioactive waste (LLW) consigned to BNFL drigg for final disposal. To achieve this the UKAEA Winfrith solid waste services section commissioned a plasma cutting facility, a lead decontamination facility and the Winfrith abrasive cleaning machine (WACM). These techniques coupled with regular supercompaction campaigns and a free release procedure ensure UKAEA Winfrith minimise the volume of LLW consigned to BNFL Drigg. This paper describes the waste minimisation techniques, the supercompaction campaigns and the free release monitoring programme employed at UKAEA Winfrith. (orig.)

  15. Reaction of Tosylmethyl Isocyanide with N-Heteroaryl Formamidines: an Alternative Approach to the Synthesis of N-Heteroaryl Tosylimidazoles

    Energy Technology Data Exchange (ETDEWEB)

    Gomezgarcia, Omar; Salgadozamora, Hector; Reyesarellano, Aliciam; Camposaldrete, Elena; Peraltacruz, Javier [Departamento Quimica Organica, Colonia (Mexico)

    2013-09-15

    In conclusion, an alternative procedure was developed under mild conditions for the synthesis of 2-(4-tosylimidazo-1-yl)pyridines and pyrimidines by the reaction of TosMIC with the corresponding heteroaryl N,N'-dimethyl form-amidines. This approach does not involve a nucleophilic displacement of a leaving group and constitutes a further application of amidines, in which TosMIC acts as both a nucleophile and an electrophile on the heteroaryl formamidine. This process offers advantages over previously reported procedures. Tosyl methyl isocyanide (TosMIC), a multipurpose commercially available 3-unit synthon introduced by Van Leusen, reacts with a variety of groups to give heterocycles. It is important to emphasize that treatment of TosMIC with various functional groups leads to the formation of the imidazole nucleus, such as is the case with imines, imidoyl chlorides, isothiocyanates, nitrile and ethoxy methylene amino. However, only the latter group yields N-heterocycle imidazoles.

  16. Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1

    Directory of Open Access Journals (Sweden)

    Hafez M. Hafez

    2012-11-01

    Full Text Available Highly pathogenic avian influenza virus (HPAIV of subtype H5N1 causes a devastating disease in poultry but when it accidentally infects humans it can cause death. Therefore, decrease the incidence of H5N1 in humans needs to focus on prevention and control of poultry infections. Conventional control strategies in poultry based on surveillance, stamping out, movement restriction and enforcement of biosecurity measures did not prevent the virus spreading, particularly in developing countries. Several challenges limit efficiency of the vaccines to prevent outbreaks of HPAIV H5N1 in endemic countries. Alternative and complementary approaches to reduce the current burden of H5N1 epidemics in poultry should be encouraged. The use of antiviral chemotherapy and natural compounds, avian-cytokines, RNA interference, genetic breeding and/or development of transgenic poultry warrant further evaluation as integrated intervention strategies for control of HPAIV H5N1 in poultry.

  17. Combining Small-Volume Metabolomic and Transcriptomic Approaches for Assessing Brain Chemistry

    OpenAIRE

    Knolhoff, Ann M.; Nautiyal, Katherine M.; Nemes, Peter; Kalachikov, Sergey; Morozova, Irina; Silver, Rae; Sweedler, Jonathan V

    2013-01-01

    The integration of disparate data types provides a more complete picture of complex biological systems. Here we combine small-volume metabolomic and transcriptomic platforms to determine subtle chemical changes and to link metabolites and genes to biochemical pathways. Capillary electrophoresis–mass spectrometry (CE–MS) and whole-genome gene expression arrays, aided by integrative pathway analysis, were utilized to survey metabolomic/transcriptomic hippocampal neurochemistry. We measured chan...

  18. Kefir grains production - An approach for volume optimization of two stage bioreactor system

    OpenAIRE

    Goršek, Andreja; Tramšek, Marko

    2012-01-01

    The main objective of the present study was to design a continuous two-stage bioreactor system for kefir grains production. Based on the experimental data of time-depended kefir grain mass increase and average pH profile during kefir grains batch propagation, parameters of predictive growth and exponential pH models were initially estimated. Afterwards, the non-linear programming (NLP) optimization problem for estimating the optimal volumes of two unequal in series connected continuously stir...

  19. Flux-Averaged and Volume-Averaged Concentrations in Continuum Approaches to Solute Transport

    Science.gov (United States)

    Parker, J. C.; van Genuchten, M. Th.

    1984-07-01

    Transformations between volume-averaged pore fluid concentrations and flux-averaged concentrations are presented which show that both modes of concentration obey convective-dispersive transport equations of identical mathematical form for nonreactive solutes. The pertinent boundary conditions for the two modes, however, do not transform identically. Solutions of the convection-dispersion equation for a semi-infinite system during steady flow subject to a first-type inlet boundary condition is shown to yield flux concentrations, while solutions subject to a third-type boundary condition yield volume-averaged concentrations. These solutions may be applied with reasonable impunity to finite as well as semi-infinite media if back mixing at the exit is precluded. Implications of the distinction between resident and flux concentrations to laboratory and field studies of solute transport are discussed. It is suggested that perceived limitations of the convection-dispersion model for media with large variations in pore water velocities may in certain cases be attributable to a failure to distinguish between volume-averaged and flux-averaged concentrations.

  20. Language acquisition for deaf children: Reducing the harms of zero tolerance to the use of alternative approaches

    Directory of Open Access Journals (Sweden)

    Humphries Tom

    2012-04-01

    Full Text Available Abstract Children acquire language without instruction as long as they are regularly and meaningfully engaged with an accessible human language. Today, 80% of children born deaf in the developed world are implanted with cochlear devices that allow some of them access to sound in their early years, which helps them to develop speech. However, because of brain plasticity changes during early childhood, children who have not acquired a first language in the early years might never be completely fluent in any language. If they miss this critical period for exposure to a natural language, their subsequent development of the cognitive activities that rely on a solid first language might be underdeveloped, such as literacy, memory organization, and number manipulation. An alternative to speech-exclusive approaches to language acquisition exists in the use of sign languages such as American Sign Language (ASL, where acquiring a sign language is subject to the same time constraints of spoken language development. Unfortunately, so far, these alternatives are caught up in an "either - or" dilemma, leading to a highly polarized conflict about which system families should choose for their children, with little tolerance for alternatives by either side of the debate and widespread misinformation about the evidence and implications for or against either approach. The success rate with cochlear implants is highly variable. This issue is still debated, and as far as we know, there are no reliable predictors for success with implants. Yet families are often advised not to expose their child to sign language. Here absolute positions based on ideology create pressures for parents that might jeopardize the real developmental needs of deaf children. What we do know is that cochlear implants do not offer accessible language to many deaf children. By the time it is clear that the deaf child is not acquiring spoken language with cochlear devices, it might already be

  1. Language acquisition for deaf children: Reducing the harms of zero tolerance to the use of alternative approaches.

    Science.gov (United States)

    Humphries, Tom; Kushalnagar, Poorna; Mathur, Gaurav; Napoli, Donna Jo; Padden, Carol; Rathmann, Christian; Smith, Scott R

    2012-01-01

    Children acquire language without instruction as long as they are regularly and meaningfully engaged with an accessible human language. Today, 80% of children born deaf in the developed world are implanted with cochlear devices that allow some of them access to sound in their early years, which helps them to develop speech. However, because of brain plasticity changes during early childhood, children who have not acquired a first language in the early years might never be completely fluent in any language. If they miss this critical period for exposure to a natural language, their subsequent development of the cognitive activities that rely on a solid first language might be underdeveloped, such as literacy, memory organization, and number manipulation. An alternative to speech-exclusive approaches to language acquisition exists in the use of sign languages such as American Sign Language (ASL), where acquiring a sign language is subject to the same time constraints of spoken language development. Unfortunately, so far, these alternatives are caught up in an "either - or" dilemma, leading to a highly polarized conflict about which system families should choose for their children, with little tolerance for alternatives by either side of the debate and widespread misinformation about the evidence and implications for or against either approach. The success rate with cochlear implants is highly variable. This issue is still debated, and as far as we know, there are no reliable predictors for success with implants. Yet families are often advised not to expose their child to sign language. Here absolute positions based on ideology create pressures for parents that might jeopardize the real developmental needs of deaf children. What we do know is that cochlear implants do not offer accessible language to many deaf children. By the time it is clear that the deaf child is not acquiring spoken language with cochlear devices, it might already be past the critical period, and

  2. Evaluation of simulation alternatives for the brute-force ray-tracing approach used in backlight design

    Science.gov (United States)

    Desnijder, Karel; Hanselaer, Peter; Meuret, Youri

    2016-04-01

    A key requirement to obtain a uniform luminance for a side-lit LED backlight is the optimised spatial pattern of structures on the light guide that extract the light. The generation of such a scatter pattern is usually performed by applying an iterative approach. In each iteration, the luminance distribution of the backlight with a particular scatter pattern is analysed. This is typically performed with a brute-force ray-tracing algorithm, although this approach results in a time-consuming optimisation process. In this study, the Adding-Doubling method is explored as an alternative way for evaluating the luminance of a backlight. Due to the similarities between light propagating in a backlight with extraction structures and light scattering in a cloud of light scatterers, the Adding-Doubling method which is used to model the latter could also be used to model the light distribution in a backlight. The backlight problem is translated to a form upon which the Adding-Doubling method is directly applicable. The calculated luminance for a simple uniform extraction pattern with the Adding-Doubling method matches the luminance generated by a commercial raytracer very well. Although successful, no clear computational advantage over ray tracers is realised. However, the dynamics of light propagation in a light guide as used the Adding-Doubling method, also allow to enhance the efficiency of brute-force ray-tracing algorithms. The performance of this enhanced ray-tracing approach for the simulation of backlights is also evaluated against a typical brute-force ray-tracing approach.

  3. Distribution of radioactive cesium in soil and approach to volume reduction with soil classification

    International Nuclear Information System (INIS)

    After the accident in the Fukushima Daiichi Nuclear Power Station caused by the 2011 Tohoku earthquake and tsunami, the decontamination of radioactive cesium spread from the Nuclear Power Station to all over the Fukushima prefecture has still been continued constantly. Moreover, the huge amount of radioactive waste typified by removed contaminated soil have been increasing on a daily basis. It is expected that the contaminated soil encumbers the acceptable amount of the interim storage facility. Therefore, various kinds of volume reduction methods are tackled. The classification method is one of feasible prospects, and is required to optimize. This study focused on the distribution of radioactive cesium in the contaminated soil for improving the volume reduction method by the soil classification. Clay minerals are reported to specifically adsorb cesium. The wet classification test proved that the fine particles classified from the actual contaminated soil in Fukushima clearly accumulated radioactive cesium, and contained clay mineral. The amount of radioactive cesium exceeding tolerance level still remained in the large particles over the size of 0.5 mm. As a result of the observation of particles the size of 0.5 mm 4.75 hand-picked by the difference in optical characters such as color and shape, particle groups showed differences of radiation quantity and composition of minerals. Especially, organic matters and soil aggregation showed high radiation quantity. Furthermore, the group of tabular particles including clay minerals, such as mica and vermiculite, showed demonstrably highest radiation quantity among particle groups. For the future, it is suggested that the classification method for the volume reduction should be improved with a focus on the clay minerals mineralogically, not mechanically. (author)

  4. Wildland fire management. Volume 1: Prevention methods and analysis. [systems engineering approach to California fire problems

    Science.gov (United States)

    Weissenberger, S. (Editor)

    1973-01-01

    A systems engineering approach is reported for the problem of reducing the number and severity of California's wildlife fires. Prevention methodologies are reviewed and cost benefit models are developed for making preignition decisions.

  5. Complementary and Alternative Medicine Approaches for Pediatric Pain: A Review of the State-of-the-science

    Directory of Open Access Journals (Sweden)

    Jennie C. I. Tsao

    2005-01-01

    Full Text Available In recent years, the use of complementary and alternative medicine (CAM in pediatric populations has increased considerably, especially for chronic conditions such as cancer, rheumatoid arthritis and cystic fibrosis in which pain may be a significant problem. Despite the growing popularity of CAM approaches for pediatric pain, questions regarding the efficacy of these interventions remain. This review critically evaluates the existing empirical evidence for the efficacy of CAM interventions for pain symptoms in children. CAM modalities that possess a published literature, including controlled trials and/or multiple baseline studies, that focused on either chronic or acute, procedural pain were included in this review. The efficacy of the CAM interventions was evaluated according to the framework developed by the American Psychological Association (APA Division 12 Task Force on Promotion and Dissemination of Psychological Procedures. According to these criteria, only one CAM approach reviewed herein (self-hypnosis/guided imagery/relaxation for recurrent pediatric headache qualified as an empirically supported therapy (EST, although many may be considered possibly efficacious or promising treatments for pediatric pain. Several methodological limitations of the existing literature on CAM interventions for pain problems in children are highlighted and future avenues for research are outlined.

  6. MuSiC: a Multibunch and multiparticle Simulation Code with an alternative approach to wakefield effects

    CERN Document Server

    Migliorati, M

    2015-01-01

    The simulation of beam dynamics in presence of collective effects requires a strong computational effort to take into account, in a self consistent way, the wakefield acting on a given charge and produced by all the others. Generally this is done by means of a convolution integral or sum. Moreover, if the electromagnetic fields consist of resonant modes with high quality factors, responsible, for example, of coupled bunch instabilities, a charge is also affected by itself in previous turns, and a very long record of wakefield must be properly taken into account. In this paper we present a new simulation code for the longitudinal beam dynamics in a circular accelerator, which exploits an alternative approach to the currently used convolution sum, reducing the computing time and avoiding the issues related to the length of wakefield for coupled bunch instabilities. With this approach it is possible to simulate, without the need of a large computing power, simultaneously, the single and multi-bunch beam dynamics...

  7. Forecasting of exported volume for brazilian fruits by time series analysis: an arima/garch approach

    Directory of Open Access Journals (Sweden)

    Abdinardo Moreira Barreto de Oliveira

    2015-06-01

    Full Text Available The aim of this paper was to offer econometric forecasting models to the Brazilian exported volume fruits, with a view to assisting the planning and production control, also motivated by the existence of a few published papers dealing with this issue. In this sense, it was used the ARIMA/GARCH models, considering, likewise, the occurrence of a multiplicative stochastic seasonality in these series. They were collected 300 observations of exported net weight (kg between Jan/1989 and Dec/2013 of the following fruits: pineapple, banana, orange, lemon, apple, papaya, mango, watermelon, melon and grape, which selection criteria was its importance in the exported basket fruit, because they represented 97% of total received dollars, and 99% of total volume sold in 2010, of a population about 28 kinds of exported fruits. The results showed that it was not only observed the existence of a 12 month multiplicative seasonality in banana and mango. On the other hand, they were identified two fruits groups: (1 those which are continuously exported, and (2 those which have export peaks. On the quality of the models, they were considered satisfactory for six of the ten fruits analyzed. On the volatility, it was seen a high persistence in banana and papaya series, pointing to the existence of a structural break in time series, which could be linked to the economic crises happened in the last 17 years.

  8. Study of transparent particles in the volume of optical medium using digital holography and singular-optics approach

    Science.gov (United States)

    Nikolaeva, Tatiana Y.; Petrov, Nikolay V.

    2015-05-01

    The study of particles that are transparent to the probing radiation but introduce a phase delay appears to be relevant especially in the fields of biology and medicine. In this paper, we propose an approach to the study of the distribution of transparent particles suspended in a volume of optical medium, which combines the method of digital holography and the concept of singular optics. For the numerical study of the particles, we use a method, based on the obtainment and analysis of zerograms that correspond to the spatial distributions of amplitude zeros of the complex amplitude of the field. We explore the features of the application of analysis of the amplitude zero distributions in solving the problem of studying transparent particles suspended in a volume of the optical medium. We investigate the effect of various particle parameters on the recorded hologram and the structure and distribution of the amplitude zeros of the electromagnetic field. We demonstrate the use of histograms of distributions of local densities of amplitude zeros for the characterization of a higher number of transparent particles in volume. Numerical experiments on the use of analysis of the amplitude zeros of the field have shown that there are a number of particular qualities in the distribution of the zeros of amplitude, which can be subsequently used to develop more accurate and efficient method of characterization of transparent particles.

  9. Evaluation, testing and application of participatory approaches in the Czech Republic Consensus panel - Spent nuclear fuel management alternatives. Deliverable 11

    International Nuclear Information System (INIS)

    An important part of the ARGONA project is the testing and application of novel participation and dialogue approaches. The ways in this is being done include a series of events involving different stakeholders such as a focused science shop, a consensus panel and an interaction panel. In the framework of these activities in the Czech Republic the consensus panel was held on June 12, 2008 in Rez and addressed the theme: 'Spent nuclear fuel management alternatives'. The main goals of this consensus panel were: 1. Identification of the main criteria relevant to the assessment of the existing alternatives and determination their importance (weight) from the perspective of all stakeholders; 2. Achieving at least a partial consensus on selecting the most suitable alternative (management of radioactive waste and spent nuclear fuel). A broader audience was selected with a suitable mixture of specialists and interested technical and non-technical peers including representatives from NRI, universities, Ministry of Industry and Trade, Ministry of the Environment, State Office for Nuclear Safety and Radioactive Waste Repository Authority, representatives of municipalities and NGOs, and waste producers such as CEZ plc etc. In opinion of all participants, there was a 'safe space' for debate ensured and everyone had the same opportunity to express his opinion. All participants also agreed that the whole course of seminar was transparent and correct. From this perspective, the chosen format of dialogue seems appropriate to ensure the exchange of new information and mutual discussion among the interested parties on the contentious issues in the NWM and nuclear energy in general. It was also found, however, that at present the social and political problems are the most important and the most urgent problems in the field of the nuclear waste management in the Czech Republic. It is very important not only to ensure a safe space for meaningful communication, but also: - To increase the

  10. An advanced approach for the generation of complex cellular material representative volume elements using distance fields and level sets

    Science.gov (United States)

    Sonon, B.; François, B.; Massart, T. J.

    2015-08-01

    A general and widely tunable method for the generation of representative volume elements for cellular materials based on distance and level set functions is presented. The approach is based on random tessellations constructed from random inclusion packings. A general methodology to obtain arbitrary-shaped tessellations to produce disordered foams is presented and illustrated. These tessellations can degenerate either in classical Voronoï tessellations potentially additively weighted depending on properties of the initial inclusion packing used, or in Laguerre tessellations through a simple modification of the formulation. A versatile approach to control the particular morphology of the obtained foam is introduced. Specific local features such as concave triangular Plateau borders and non-constant thickness heterogeneous coatings can be built from the tessellation in a straightforward way and are tuned by a small set of parameters with a clear morphological interpretation.

  11. Mediation in industry and business, an alternative dispute resolution approach illustrated by examples from the energy industry; Wirtschaftsmediation, ein alternatives Konfliktloesungsverfahren - dargestellt am Beispiel der Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Neuenhahn, H.U.

    2001-07-01

    It could be observed in Germany that market deregulation and correspondingly increasing competition among marketers brought about an increasing potential of conflicts among industrial market participants. The article describes and discusses the capabilities and advantages of mediation in the energy sector as an alternative to dispute resolution by way of legal proceedings which already has proven successful in other sectors of the economy, not least for instance as an alternative that saves money and time. (orig./CB) [German] In dem Masse, in dem der Wettbewerb die Unternehmen im notwendigen Kampf um Marktanteile und damit Kunden erfasst hat, in diesem Masse steigt auch das Konfliktpotenzial im Umgang der Unternehmen untereinander an. Der folgende Artikel beschreibt die Moeglichkeiten und Vorteile einer alternativen Konfliktbeilegung, die in anderen Bereichen der Wirtschaft bereits auf eine erfolgreiche Entwicklung zurueckblicken. (orig./CB)

  12. Alternative approaches in IVF

    NARCIS (Netherlands)

    B.C.J.M. Fauser (Bart); P. Bouchard; H.J. Coelingh Bennink; J.A. Collins (John); P. Devroey; J.L.H. Evers (Johannes); A. van Steirteghem

    2002-01-01

    textabstractVarious new developments in clinical and basic science which may impact on IVF in the near or distant future will be discussed in this review. These key areas include the regulation of early follicle development and the extended in-vitro culture of oocytes and embryos.

  13. An alternative approach for the use of water solubility of nonionic pesticides in the modeling of the soil sorption coefficients.

    Science.gov (United States)

    dos Reis, Ralpho Rinaldo; Sampaio, Silvio César; de Melo, Eduardo Borges

    2014-04-15

    The collection of data to study the damage caused by pesticides to the environment and its ecosystems is slowly acquired and costly. Large incentives have been established to encourage research projects aimed at building mathematical models for predicting physical, chemical or biological properties of environmental interest. The organic carbon normalized soil sorption coefficient (K(oc)) is an important physicochemical property used in environmental risk assessments for compounds released into the environment. Many models for predicting logK(oc) that have used the parameters logP or logS as descriptors have been published in recent decades. The strong correlation between these properties (logP and logS) prevents them from being used together in multiple linear regressions. Because the sorption of a chemical compound in soil depends on both its water solubility and its water/organic matter partitioning, we assume that models capable of combining these two properties can generate more realistic results. Therefore, the objective of this study was to propose an alternative approach for modeling logK(oc), using a simple descriptor of solubility, here designated as the logarithm of solubility corrected by octanol/water partitioning (logS(P)). Thus, different models were built with this descriptor and with the conventional descriptors logP and logS, alone or associated with other explanatory variables representing easy-to-interpret physicochemical properties. The obtained models were validated according to current recommendations in the literature, and they were compared with other previously published models. The results showed that the use of logS(p) instead of conventional descriptors led to simple models with greater statistical quality and predictive power than other more complex models found in the literature. Therefore, logS(P) can be a good alternative to consider for the modeling of logK(oc) and other properties that relate to both solubility and water

  14. Signal transduction profile of chemical sensitisers in dendritic cells: an endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

    OpenAIRE

    Neves, BM; Gonçalo, Margarida; Figueiredo, A.; Duarte, CB; Lopes, MC; Cruz, MT

    2011-01-01

    The development of non-animal testing methods for the assessment of skin sensitisation potential is an urgent challenge within the framework of existing and forthcoming legislation. Efforts have been made to replace current animal tests, but so far no alternative methods have been developed. It is widely recognised that alternatives to animal testing cannot be accomplished with a single approach, but rather will require the integration of results obtained from different in vitro and in silico...

  15. A finite volume approach for the simulation of nonlinear dissipative acoustic wave propagation

    CERN Document Server

    Velasco-Segura, Roberto

    2013-01-01

    A form of the conservation equations for fluid dynamics is presented, deduced using slightly less restrictive hypothesis than those necessary to obtain the well known Westervelt equation. This formulation accounts for full wave diffraction, nonlinearity, and thermoviscous dissipative effects. A CLAWPACK based, 2D finite volume method using the Roe linearization was implemented to obtain numerically the solution of the proposed equations. In order to validate the code, two different tests have been performed: one against a special Taylor shock-like analytic solution, the other against published results on a HIFU system, both with satisfactory results. The code is based on CLAWPACK and is written for parallel execution on a GPU, thus improving performance by a factor of over 60 when compared to the standard CLAWPACK code.

  16. Replication needed to detect alterations in the composition of rodent, rabbit, or human testes via volume density approaches.

    Science.gov (United States)

    Berndtson, William E

    2010-01-01

    Sperm production is an important variable affecting the reproductive capacity of men and other male mammals. Because spermatogenesis is highly susceptible to disruption, volume density techniques that enable the composition of testicular tissue to be characterized or sperm production rates to be quantified are used extensively to assess potential impacts of known or suspected reproductive toxins, the safety of proposed human or animal drugs, and basic studies on spermatogenesis in normal individuals. The number of subjects used per treatment group for such studies has been variable. However, the power and sensitivity of any experiment is dependent on the inherent variability associated with the end point(s) of interest and the number of replicates (ie, animals or men per treatment group) employed per treatment group. Because the reliability of one's experimental outcome should be of utmost consideration, it is important to characterize the typical levels of inherent variability associated with one's chosen end point(s) and to answer the question: how many subjects are required per treatment group to provide an experiment with a given power and sensitivity for detecting actual treatment effects? This study was undertaken to 1) characterize the inherent variability associated with the volume density of several testicular components in rodents, rabbits, and humans and among cell numbers derived from volume density data and 2) identify the approximate number of replicates that would be required to provide future studies of predictable power and sensitivity for which data were to be generated via the volume density approach. Replication requirements differed, sometimes by several orders of magnitude, among these species and among end points within a single species. In addition, for many of these species and end points, the number of replicates necessary to ensure modest power and sensitivity for detecting treatment differences exceeded that used in most investigations

  17. Direct evaluation of radiobiological parameters from clinical data in the case of ion beam therapy: an alternative approach to the relative biological effectiveness

    International Nuclear Information System (INIS)

    The relative biological effectiveness (RBE) concept is commonly used in treatment planning for ion beam therapy. Whether models based on in vitro/in vivo RBE data can be used to predict human response to treatments is an open issue. In this work an alternative method, based on an effective radiobiological parameterization directly derived from clinical data, is presented. The method has been applied to the analysis of prostate cancer trials with protons and carbon ions. Prostate cancer trials with proton and carbon ion beams reporting 5 year-local control (LC5) and grade 2 (G2) or higher genitourinary toxicity rates (TOX) were selected from literature to test the method. Treatment simulations were performed on a representative subset of patients to produce dose and linear energy transfer distribution, which were used as explicative physical variables for the radiobiological modelling. Two models were taken into consideration: the microdosimetric kinetic model (MKM) and a linear model (LM). The radiobiological parameters of the LM and MKM were obtained by coupling them with the tumor control probability and normal tissue complication probability models to fit the LC5 and TOX data through likelihood maximization. The model ranking was based on the Akaike information criterion. Results showed large confidence intervals due to the limited variety of available treatment schedules. RBE values, such as RBE = 1.1 for protons in the treated volume, were derived as a by-product of the method, showing a consistency with current approaches. Carbon ion RBE values were also derived, showing lower values than those assumed for the original treatment planning in the target region, whereas higher values were found in the bladder. Most importantly, this work shows the possibility to infer the radiobiological parametrization for proton and carbon ion treatment directly from clinical data. (paper)

  18. Autologous Fat Grafting as a Novel Approach to Parastomal Soft-tissue Volume Deficiencies

    Directory of Open Access Journals (Sweden)

    Robert C. Wu, MD

    2014-03-01

    Full Text Available Summary: The aim of this study is to describe a novel approach to revise maladaptive soft-tissue contour around an ileostomy. A patient with permanent ileostomy suffered from significant defects in soft-tissue contour due to scarring and wound contraction. He underwent autologous fat grafting to achieve sealing of his stoma appliance and improve cosmesis. Due to numerous surgeries, the stoma appliance would not seal and required daily appliance changes. The patient received autologous fat grafting to augment the contour around stoma. A complete fitting of stoma was achieved. The patient is satisfied with stoma sealing and is changing his stoma appliance every 5–7 days without skin excoriation. Autologous fat transfer is an effective approach to treat a subset of stoma patients with complex subcutaneous defects.

  19. Autologous Fat Grafting as a Novel Approach to Parastomal Soft-tissue Volume Deficiencies

    OpenAIRE

    Robert C. Wu, MD; Ian Maxwell, MD; Ilun Yang, MD, FRCSC; Mario B. Jarmuske, MD, FRCSC; Robin P. Boushey, MD, PhD, FRCSC

    2014-01-01

    Summary: The aim of this study is to describe a novel approach to revise maladaptive soft-tissue contour around an ileostomy. A patient with permanent ileostomy suffered from significant defects in soft-tissue contour due to scarring and wound contraction. He underwent autologous fat grafting to achieve sealing of his stoma appliance and improve cosmesis. Due to numerous surgeries, the stoma appliance would not seal and required daily appliance changes. The patient received autologous fat gra...

  20. MLAIR: a novel alternative approach to Gjedde-Patlak graphical analysis for the quantification of irreversible radiotracers

    International Nuclear Information System (INIS)

    Gjedde-Patlak graphical analysis (PGA) has commonly been used to quantify the net accumulations (Ki) of radioligands that bind or are uptaken irreversibly. However, this method has limited accuracy for some tracers which show regional time differences in terms of achieving tissue-plasma equilibria. In this study, we suggest an alternative approach (MLAIR: Multiple Linear Analysis for Irreversible Radiotracers) for the quantification of these types of tracers. Two multiple linear regression model equations were derived from differential equations of the two-tissue compartment model with irreversible binding. The first equation (MLAIR1) has a desirable feature for ordinary least square estimations because only the dependent variable CT (t) is noisy. The second equation (MLAIR2) provides Ki from direct estimates of the coefficients of independent variables without the mediation of a division operation. Computer simulations were performed to assess the statistical properties of the parameter estimations using these two methods. Dynamic PET data acquired using [11C]MeNTI, were also analyzed to assess the usefulnesses of these two methods for VOl analysis and parametric image generation. All the properties of these two methods were compared with those of PGA and NLS. In simulations, MLAIR1 provided less biased Ki estimates than the other linear methods, but showed a high uncertainty level for noisy data, whereas MLAIR2 increased the robustness of estimation in terms of variability, but at the expense of increased bias. Both methods were computationally efficient and showed good correlations with the standard NLS method. MLAIR2 parametric images showed remarkable image quality and improved statistical power for voxel-wise comparisons than PGA. The two MLAIR approaches examined were found to have several advantages over the conventional PGA method, and would be useful for the quantification of irreversible radiotracers

  1. Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy.

    Science.gov (United States)

    He, Tiantian; Hatem, Elie; Vernis, Laurence; Huang, Meng-Er

    2014-10-01

    Peroxiredoxins have multiple cellular functions as major antioxidants, signaling regulators and tumor suppressors. Peroxiredoxin 1 (PRX1) is the most abundant among the six isoforms of human peroxiredoxins, catalyzing the reduction of peroxides utilizing thioredoxin 1as an electron donor. PRX1 is frequently over-expressed in various cancer cells, which is thought to be associated with carcinogenesis, metastasis and resistance to radiotherapy or chemotherapy. We investigated how modulations of intracellular redox system, especially PRX1, affect cancer cell sensitivity to reactive oxygen species (ROS)-generating drugs. We observed that stable and transient Prx1 knockdown (Prx1-) significantly enhances HeLa cell sensitivity to β-lapachone (β-lap), a potential anticancer agent, and to other ROS-generating molecules. ROS accumulation played a crucial role in drug-enhanced Prx1- cell death. For β-lap, Prx1- cells sensitization is achieved through combined action of accumulation of ROS and enhancement of mitogen-activated protein kinase pathway activation. The effect of other ROS-inducing drugs on Prx1- cell survival will also be presented and discussed. Taken together, our data provide evidence that PRX1 could be an interesting anticancer target and modulation of intracellular redox states through PRX1 inhibition could be an alternative approach to enhance cancer cell sensitivity to ROS-generating drugs. PMID:26461286

  2. Effect of dense plasmas on exchange-energy shifts in highly charged ions: An alternative approach for arbitrary perturbation potentials

    Energy Technology Data Exchange (ETDEWEB)

    Rosmej, F. [Sorbonne Universites, Pierre et Marie Curie, UMR 7605, case 128, 4 place Jussieu, F-75252 Paris (France); Ecole Polytechnique, Laboratoire pour l' Utilisation des Lasers Intenses LULI, Physique Atomique dans les Plasmas Denses PAPD, F-91228 Palaiseau (France); Bennadji, K. [Sorbonne Universites, Pierre et Marie Curie, UMR 7605, case 128, 4 place Jussieu, F-75252 Paris (France); ExtreMe Matter Institute EMMI, GSI Helmholtz Centre of Heavy Ion Research, Planckstrasse 1, D-64291 Darmstadt (Germany); Lisitsa, V. S. [Russian Research Center Kurchatov, Laboratory of Radiation Theory, Kurchatov Square 1, 123182 Moscow (Russian Federation)

    2011-09-15

    An alternative method of calculation of dense plasma effects on exchange-energy shifts {Delta}E{sub x} of highly charged ions is proposed which results in closed expressions for any plasma or perturbation potential. The method is based on a perturbation theory expansion for the inner atomic potential produced by charged plasma particles employing the Coulomb Green function method. This approach allows us to obtain analytic expressions and scaling laws with respect to the electron temperature T, density n{sub e}, and nuclear charge Z. To demonstrate the power of the present method, two specific models were considered in detail: the ion sphere model (ISM) and the Debye screening model (DSM). We demonstrate that analytical expressions can be obtained even for the finite temperature ISM. Calculations have been carried out for the singlet 1s2p{sup 1} P{sub 1} and triplet 1s2p{sup 3} P{sub 1} configurations of He-like ions with charge Z that can be observed in dense plasmas via the He-like resonance and intercombination lines. Finally we discuss recently available purely numerical calculations and experimental data.

  3. A multiobjective ant colony optimization approach for scheduling environmental flow management alternatives with application to the River Murray, Australia

    Science.gov (United States)

    Szemis, J. M.; Dandy, G. C.; Maier, H. R.

    2013-10-01

    In regulated river systems, such as the River Murray in Australia, the efficient use of water to preserve and restore biota in the river, wetlands, and floodplains is of concern for water managers. Available management options include the timing of river flow releases and operation of wetland flow control structures. However, the optimal scheduling of these environmental flow management alternatives is a difficult task, since there are generally multiple wetlands and floodplains with a range of species, as well as a large number of management options that need to be considered. Consequently, this problem is a multiobjective optimization problem aimed at maximizing ecological benefit while minimizing water allocations within the infrastructure constraints of the system under consideration. This paper presents a multiobjective optimization framework, which is based on a multiobjective ant colony optimization approach, for developing optimal trade-offs between water allocation and ecological benefit. The framework is applied to a reach of the River Murray in South Australia. Two studies are formulated to assess the impact of (i) upstream system flow constraints and (ii) additional regulators on this trade-off. The results indicate that unless the system flow constraints are relaxed, there is limited additional ecological benefit as allocation increases. Furthermore the use of regulators can increase ecological benefits while using less water. The results illustrate the utility of the framework since the impact of flow control infrastructure on the trade-offs between water allocation and ecological benefit can be investigated, thereby providing valuable insight to managers.

  4. Multiple-Use Services as an Alternative to Rural Water Supply Services: A Characterisation of the Approach

    Directory of Open Access Journals (Sweden)

    Stef Smits

    2010-02-01

    Full Text Available Multiple-use services (MUS have recently gained increased attention as an alternative form of providing rural water services in an integrated manner. This stems from the growing recognition that users anyway tend to use water systems for multiple purposes. This paper aims to characterise this practice on the basis of case evidence collected in eight countries in Africa, Asia and Latin America. The cases show that people almost universally use water for both domestic and productive activities at and around the homestead. Although seldom the main source of people’s income or food production, these activities are of considerable importance for people’s livelihoods. The extent to which people use water for multiple purposes is closely related to the level of access to water expressed in the form of a water ladder in this paper. The case studies presented demonstrate how access is created by different types and combinations of well-known technologies. Additional financial and management measures are required to ensure sustainability of services. Despite the practical feasibility of the MUS approach, it is not yet widely applied by service providers and sector agencies due to observed barriers in institutional uptake. A better characterisation of MUS, alongside a learning-driven stakeholder process was able to overcome some of these barriers and improve the consideration of multiple uses of water in policy and practice.

  5. A novel convolution-based approach to address ionization chamber volume averaging effect in model-based treatment planning systems

    International Nuclear Information System (INIS)

    The ionization chamber volume averaging effect is a well-known issue without an elegant solution. The purpose of this study is to propose a novel convolution-based approach to address the volume averaging effect in model-based treatment planning systems (TPSs). Ionization chamber-measured beam profiles can be regarded as the convolution between the detector response function and the implicit real profiles. Existing approaches address the issue by trying to remove the volume averaging effect from the measurement. In contrast, our proposed method imports the measured profiles directly into the TPS and addresses the problem by reoptimizing pertinent parameters of the TPS beam model. In the iterative beam modeling process, the TPS-calculated beam profiles are convolved with the same detector response function. Beam model parameters responsible for the penumbra are optimized to drive the convolved profiles to match the measured profiles. Since the convolved and the measured profiles are subject to identical volume averaging effect, the calculated profiles match the real profiles when the optimization converges. The method was applied to reoptimize a CC13 beam model commissioned with profiles measured with a standard ionization chamber (Scanditronix Wellhofer, Bartlett, TN). The reoptimized beam model was validated by comparing the TPS-calculated profiles with diode-measured profiles. Its performance in intensity-modulated radiation therapy (IMRT) quality assurance (QA) for ten head-and-neck patients was compared with the CC13 beam model and a clinical beam model (manually optimized, clinically proven) using standard Gamma comparisons. The beam profiles calculated with the reoptimized beam model showed excellent agreement with diode measurement at all measured geometries. Performance of the reoptimized beam model was comparable with that of the clinical beam model in IMRT QA. The average passing rates using the reoptimized beam model increased substantially from 92.1% to

  6. A novel convolution-based approach to address ionization chamber volume averaging effect in model-based treatment planning systems

    Science.gov (United States)

    Barraclough, Brendan; Li, Jonathan G.; Lebron, Sharon; Fan, Qiyong; Liu, Chihray; Yan, Guanghua

    2015-08-01

    The ionization chamber volume averaging effect is a well-known issue without an elegant solution. The purpose of this study is to propose a novel convolution-based approach to address the volume averaging effect in model-based treatment planning systems (TPSs). Ionization chamber-measured beam profiles can be regarded as the convolution between the detector response function and the implicit real profiles. Existing approaches address the issue by trying to remove the volume averaging effect from the measurement. In contrast, our proposed method imports the measured profiles directly into the TPS and addresses the problem by reoptimizing pertinent parameters of the TPS beam model. In the iterative beam modeling process, the TPS-calculated beam profiles are convolved with the same detector response function. Beam model parameters responsible for the penumbra are optimized to drive the convolved profiles to match the measured profiles. Since the convolved and the measured profiles are subject to identical volume averaging effect, the calculated profiles match the real profiles when the optimization converges. The method was applied to reoptimize a CC13 beam model commissioned with profiles measured with a standard ionization chamber (Scanditronix Wellhofer, Bartlett, TN). The reoptimized beam model was validated by comparing the TPS-calculated profiles with diode-measured profiles. Its performance in intensity-modulated radiation therapy (IMRT) quality assurance (QA) for ten head-and-neck patients was compared with the CC13 beam model and a clinical beam model (manually optimized, clinically proven) using standard Gamma comparisons. The beam profiles calculated with the reoptimized beam model showed excellent agreement with diode measurement at all measured geometries. Performance of the reoptimized beam model was comparable with that of the clinical beam model in IMRT QA. The average passing rates using the reoptimized beam model increased substantially from 92.1% to

  7. An Approach to the Use of Depth Cameras for Weed Volume Estimation.

    Science.gov (United States)

    Andújar, Dionisio; Dorado, José; Fernández-Quintanilla, César; Ribeiro, Angela

    2016-01-01

    The use of depth cameras in precision agriculture is increasing day by day. This type of sensor has been used for the plant structure characterization of several crops. However, the discrimination of small plants, such as weeds, is still a challenge within agricultural fields. Improvements in the new Microsoft Kinect v2 sensor can capture the details of plants. The use of a dual methodology using height selection and RGB (Red, Green, Blue) segmentation can separate crops, weeds, and soil. This paper explores the possibilities of this sensor by using Kinect Fusion algorithms to reconstruct 3D point clouds of weed-infested maize crops under real field conditions. The processed models showed good consistency among the 3D depth images and soil measurements obtained from the actual structural parameters. Maize plants were identified in the samples by height selection of the connected faces and showed a correlation of 0.77 with maize biomass. The lower height of the weeds made RGB recognition necessary to separate them from the soil microrelief of the samples, achieving a good correlation of 0.83 with weed biomass. In addition, weed density showed good correlation with volumetric measurements. The canonical discriminant analysis showed promising results for classification into monocots and dictos. These results suggest that estimating volume using the Kinect methodology can be a highly accurate method for crop status determination and weed detection. It offers several possibilities for the automation of agricultural processes by the construction of a new system integrating these sensors and the development of algorithms to properly process the information provided by them. PMID:27347972

  8. Draft Programmatic Environmental Impact Statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 1: Main text

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky; Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. The preferred alternative for the long-term management of depleted UF6 is to use the entire inventory of material

  9. Cat dissection and human cadaver prosection versus sculpting human structures from clay: A comparison of alternate approaches to human anatomy laboratory education

    Science.gov (United States)

    Waters, John R.

    Dissection and vivisection are traditional approaches to biology laboratory education. In the case of human anatomy teaching laboratories, there is a long tradition of using human and animal cadaver specimens in the classroom. In a review of the literature comparing traditional dissection and vivisection lessons to alternative lessons designed to reduce the time spent dissecting or the numbers of animals used, we conclude that it is difficult to come to any conclusion regarding the efficacy of different approaches. An analysis of the literature is confounded because many studies have very low statistical power or other methodological weaknesses, and investigators rely on a wide variety of testing instruments to measure an equally varied number of course objectives. Additional well designed studies are necessary before educators can reach any informed conclusions about the efficacy of traditional versus alternative approaches to laboratory education. In our experiments, we compared a traditional cat dissection based undergraduate human anatomy lesson to an alternative where students sculpted human muscles onto plastic human skeletons. Students in the alternative treatment performed significantly better than their peers in the traditional treatment when answering both lower and higher order human anatomy questions. In a subsequent experiment with a similar design, we concluded that the superior performance of the students in the alternative treatment on anatomy exams was likely due to the similarity between the human anatomy representation studied in lab, and the human anatomy questions asked on the exams. When the anatomy questions were presented in the context of a cat specimen, students in the traditional cat dissection treatment outperformed their peers in the alternative treatment. In a final experiment where student performance on a human anatomy exam was compared between a traditional prosected human cadaver treatment and the alternative clay sculpting

  10. The Supply of Medical Isotopes - An Assessment of the Market Economics, Alternative Technologies and Proposed Policy Approach to Achieving Sustainability

    International Nuclear Information System (INIS)

    At the request of its member countries, the OECD Nuclear Energy Agency (NEA) has become involved in global efforts to ensure a reliable supply of molybdenum-99 (99Mo) and its decay product, technetium-99m (99mTc), the most widely used medical radioisotope. The NEA established the High-level Group on the Security of Supply of Medical Radioisotopes (HLG-MR). The main objective of the HLG-MR is to strengthen the reliability of 99Mo and 99mTc supply in the short, medium and long term. In order to reach this objective, the group has been reviewing the 99Mo supply chain, working to identify the key areas of vulnerability, the issues that need to be addressed and the mechanisms that could be used to help resolve them. The collective efforts of HLG-MR members and nuclear medicine stakeholders have allowed for a comprehensive assessment of the key areas of vulnerability in the supply chain and an identification of the issues that need to be addressed. As a result of the work undertaken to date, the NEA has released three reports under the new The Supply of Medical Radioisotopes series. These reports discuss the uneconomical situation of the supply chain, other vulnerabilities within the supply chain and alternative technologies to produce 99Mo/99mTc. From this work, the NEA Secretariat and the HLG-MR have started to develop the policy approach and recommendations for governments, industry and other stakeholders that will outline the foundation for ensuring the long-term supply of 99Mo/99mTc. (author)

  11. Alternative approaches to correct interferences in the determination of boron in shrimps by electrothermal atomic absorption spectrometry

    International Nuclear Information System (INIS)

    The aim of this study is to propose alternative techniques and methods in combination with the classical chemical modification to correct the major matrix interferences in the determination of boron in shrimps. The performance of an internal standard (Ge) for the determination of boron by the simultaneous multi-element atomic absorption spectrometry was tested. The use of internal standardization increased the recovery from 85.9% to 101% and allowed a simple correction of errors during sampling preparation and heating process. Furthermore, a new preparation procedure based on the use of citric acid during digestion and dilution steps improved the sensitivity of the method and decreased the limit of detection. Finally, a comparative study between the simultaneous multi-element atomic absorption spectrometry with a longitudinal Zeeman-effect background correction system, equipped with a transversely-heated graphite atomizer and the single element atomic absorption spectrometry with a D2 background correction system, equipped with an end-heated graphite atomizer was undertaken to investigate the different behavior of boron in both techniques. Different chemical modifiers for the determination of boron were tested with both techniques. Ni-citric acid and Ca were the optimal chemical modifiers when simultaneous multi-element atomic absorption spectrometry and single-element atomic absorption spectrometry were used, respectively. By using the single-element atomic absorption spectrometry, the calculated characteristic mass was 220 pg and the calculated limit of detection was 370 μg/kg. On the contrary, with simultaneous multi-element atomic absorption spectrometry, the characteristic mass was 2200 pg and the limit of detection was 5.5 mg/kg. - Highlights: • New approaches were developed to cope with interferences of B determination by ETAAS • Ge was used as internal standard for the determination of B by simultaneous ETAAS • Citric acid was used during digestion

  12. Subcutaneous dissociative conscious sedation (sDCS an alternative method for airway regional blocks: a new approach

    Directory of Open Access Journals (Sweden)

    Javid Mihan J

    2011-10-01

    Full Text Available Abstract Background Predicted difficult airway is a definite indication for awake intubation and spontaneous ventilation. Airway regional blocks which are commonly used to facilitate awake intubation are sometimes impossible or forbidden. On the other hand deep sedation could be life threatening in the case of compromised airway. The aim of this study is evaluating "Subcutaneous Dissociative Conscious Sedation" (sDCS as an alternative method to airway regional blocks for awake intubation. Methods In this prospective, non-randomized study, 30 patients with predicted difficult airway (laryngeal tumors, who were scheduled for direct laryngoscopic biopsy (DLB, underwent "Subcutaneous Dissociative Conscious Sedation" (sDCS exerted by intravenous fentanyl 3-4ug/kg and subcutaneous ketamine 0.6-0.7 mg/kg. The tongue and pharynx were anesthetized with lidocaine spray (4%. 10 minutes after a subcutaneous injection of ketamine direct laryngoscopy was performed. Extra doses of fentanyl 50-100 ug were administered if the patient wasn't cooperative enough for laryngoscopy. Patients were evaluated for hemodynamic stability (heart rate and blood pressure, oxygen saturation (Spo2, patient cooperation (obedient to open the mouth for laryngoscopy and the number of tries for laryngoscopy, patient comfort (remaining moveless, hallucination, nystagmus and salivation (need for aspiration before laryngoscopy. Results Direct laryngoscopy was performed successfully in all patients. One patient needed extra fentanyl and then laryngoscopy was performed successfully on the second try. All patients were cooperative enough during laryngoscopy. Hemodynamic changes more than 20% occurred in just one patient. Oxygen desaturation (spo2 Conclusions Subcutaneous Dissociative Conscious Sedation (sDCS as a new approach to airway is an acceptable and safe method for awake intubation and it can be suggested as a noninvasive substitute of low complication rate for regional airway

  13. The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism

    Directory of Open Access Journals (Sweden)

    Hoskins Clare

    2012-04-01

    Full Text Available Abstract Background Iron oxide magnetic nanoparticles (MNP's have an increasing number of biomedical applications. As such in vitro characterisation is essential to ensure the bio-safety of these particles. Little is known on the cellular interaction or effect on membrane integrity upon exposure to these MNPs. Here we synthesised Fe3O4 and surface coated with poly(ethylenimine (PEI and poly(ethylene glycol (PEG to achieve particles of varying surface positive charges and used them as model MNP's to evaluate the relative utility and limitations of cellular assays commonly applied for nanotoxicity assessment. An alternative approach, atomic force microscopy (AFM, was explored for the analysis of membrane structure and cell morphology upon interacting with the MNPs. The particles were tested in vitro on human SH-SY5Y, MCF-7 and U937 cell lines for reactive oxygen species (ROS production and lipid peroxidation (LPO, LDH leakage and their overall cytotoxic effect. These results were compared with AFM topography imaging carried out on fixed cell lines. Results Successful particle synthesis and coating were characterised using FTIR, PCS, TEM and ICP. The particle size from TEM was 30 nm (−16.9 mV which increased to 40 nm (+55.6 mV upon coating with PEI and subsequently 50 nm (+31.2 mV with PEG coating. Both particles showed excellent stability not only at neutral pH but also in acidic environment of pH 4.6 in the presence of sodium citrate. The higher surface charge MNP-PEI resulted in increased cytotoxic effect and ROS production on all cell lines compared with the MNP-PEI-PEG. In general the effect on the cell membrane integrity was observed only in SH-SY5Y and MCF-7 cells by MNP-PEI determined by LDH leakage and LPO production. AFM topography images showed consistently that both the highly charged MNP-PEI and the less charged MNP-PEI-PEG caused cell morphology changes possibly due to membrane disruption and cytoskeleton remodelling. Conclusions

  14. A forecast of household ownership and use of alternative fuel vehicles: A multiple discrete-continuous choice approach

    International Nuclear Information System (INIS)

    The paper analyzes how adding alternative fuel passenger cars to the market will affect patterns in demand for passenger cars. We use conjoint analysis and a multiple discrete-continuous choice model to estimate consumer preferences regarding alternative fuel vehicles, and based on the estimates we conduct a simulation to analyze changing rates of ownership and use of variously fueled passenger cars under the effect of the introduction of alternative fuel passenger cars. In addition, we estimate changes in overall fuel consumption and the emission of pollutants. The results show that gasoline-fueled cars will still be most consumers' first choice, but alternative fuel passenger cars will nevertheless compete and offer a substitute for the purchase and use of gasoline-fueled or diesel-fueled cars. Finally, results show that adding alternative fuel cars to the market would effectively lower gasoline and diesel fuel consumption and the emission of pollutants. (author)

  15. A forecast of household ownership and use of alternative fuel vehicles: A multiple discrete-continuous choice approach

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Jiwoon [Korea Energy Economics Institute, Naeson 2-dong, Uiwang-si, Gyeonggi-do, 437-713 (Korea); Jeong, Gicheol [Technology Management, Economics and Policy Program, 37-402, College of Engineering, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul, 151-744 (Korea); Kim, Yeonbae [Technology Management, Economics and Policy Program, 37-318, College of Engineering, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, South Seoul, 151-744 (Korea)

    2008-09-15

    The paper analyzes how adding alternative fuel passenger cars to the market will affect patterns in demand for passenger cars. We use conjoint analysis and a multiple discrete-continuous choice model to estimate consumer preferences regarding alternative fuel vehicles, and based on the estimates we conduct a simulation to analyze changing rates of ownership and use of variously fueled passenger cars under the effect of the introduction of alternative fuel passenger cars. In addition, we estimate changes in overall fuel consumption and the emission of pollutants. The results show that gasoline-fueled cars will still be most consumers' first choice, but alternative fuel passenger cars will nevertheless compete and offer a substitute for the purchase and use of gasoline-fueled or diesel-fueled cars. Finally, results show that adding alternative fuel cars to the market would effectively lower gasoline and diesel fuel consumption and the emission of pollutants. (author)

  16. Computationally efficient approach for the minimization of volume constrained vector-valued Ginzburg-Landau energy functional

    Science.gov (United States)

    Tavakoli, Rouhollah

    2015-08-01

    The minimization of volume constrained vector-valued Ginzburg-Landau energy functional is considered in the present study. It has many applications in computational science and engineering, like the conservative phase separation in multiphase systems (such as the spinodal decomposition), phase coarsening in multiphase systems, color image segmentation and optimal space partitioning. A computationally efficient algorithm is presented to solve the space discretized form of the original optimization problem. The algorithm is based on the constrained nonmonotone L2 gradient flow of Ginzburg-Landau functional followed by a regularization step, which is resulted from the Tikhonov regularization term added to the objective functional, that lifts the solution from the L2 function space into H1 space. The regularization step not only improves the convergence rate of the presented algorithm, but also increases its stability bound. The step-size selection based on the Barzilai-Borwein approach is adapted to improve the convergence rate of the introduced algorithm. The success and performance of the presented approach is demonstrated throughout several numerical experiments. To make it possible to reproduce the results presented in this work, the MATLAB implementation of the presented algorithm is provided as the supplementary material.

  17. A data-driven approach for modeling post-fire debris-flow volumes and their uncertainty

    Science.gov (United States)

    Friedel, M.J.

    2011-01-01

    This study demonstrates the novel application of genetic programming to evolve nonlinear post-fire debris-flow volume equations from variables associated with a data-driven conceptual model of the western United States. The search space is constrained using a multi-component objective function that simultaneously minimizes root-mean squared and unit errors for the evolution of fittest equations. An optimization technique is then used to estimate the limits of nonlinear prediction uncertainty associated with the debris-flow equations. In contrast to a published multiple linear regression three-variable equation, linking basin area with slopes greater or equal to 30 percent, burn severity characterized as area burned moderate plus high, and total storm rainfall, the data-driven approach discovers many nonlinear and several dimensionally consistent equations that are unbiased and have less prediction uncertainty. Of the nonlinear equations, the best performance (lowest prediction uncertainty) is achieved when using three variables: average basin slope, total burned area, and total storm rainfall. Further reduction in uncertainty is possible for the nonlinear equations when dimensional consistency is not a priority and by subsequently applying a gradient solver to the fittest solutions. The data-driven modeling approach can be applied to nonlinear multivariate problems in all fields of study. ?? 2011.

  18. Validation of analytical methods in GMP: the disposable Fast Read 102® device, an alternative practical approach for cell counting

    Directory of Open Access Journals (Sweden)

    Gunetti Monica

    2012-05-01

    Full Text Available Abstract Background The quality and safety of advanced therapy products must be maintained throughout their production and quality control cycle to ensure their final use in patients. We validated the cell count method according to the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use and European Pharmacopoeia, considering the tests’ accuracy, precision, repeatability, linearity and range. Methods As the cell count is a potency test, we checked accuracy, precision, and linearity, according to ICH Q2. Briefly our experimental approach was first to evaluate the accuracy of Fast Read 102® compared to the Bürker chamber. Once the accuracy of the alternative method was demonstrated, we checked the precision and linearity test only using Fast Read 102®. The data were statistically analyzed by average, standard deviation and coefficient of variation percentages inter and intra operator. Results All the tests performed met the established acceptance criteria of a coefficient of variation of less than ten percent. For the cell count, the precision reached by each operator had a coefficient of variation of less than ten percent (total cells and under five percent (viable cells. The best range of dilution, to obtain a slope line value very similar to 1, was between 1:8 and 1:128. Conclusions Our data demonstrated that the Fast Read 102® count method is accurate, precise and ensures the linearity of the results obtained in a range of cell dilution. Under our standard method procedures, this assay may thus be considered a good quality control method for the cell count as a batch release quality control test. Moreover, the Fast Read 102® chamber is a plastic, disposable device that allows a number of samples to be counted in the same chamber. Last but not least, it overcomes the problem of chamber washing after use and so allows a cell count in a clean environment such as that in a

  19. An Alternative Georoute: Approaching the Geological Heritage of the SE Part of Milos Island, Greece, via Hiking, Kayaking and Snorkeling

    Science.gov (United States)

    Mavrogonatos, Constantinos; Galanopoulos, Evangelos; Anastasatou, Marianthi; Chadjimpaloglou, Petros; Xydous, Stamatios

    2015-04-01

    Milos Island is located at the southwest edge of the Cyclades island complex, in the central part of the Aegean archipelago. It is part of the modern South Aegean Volcanic Arc (SAVA), which belongs to the Hellenic subduction zone. This on-going process has resulted in the coexistence of complex geological formations and geodynamic phenomena with sceneries of incomparable natural beauty, in many areas along the arc. Among them, Milos Island is widely known to be a place of astonishing geological and natural wealth, combined with a cultural heritage that dates back to the 8th millennium BC. As geotourism has been rapidly evolving worldwide over the last years, Milos Island was among the first places in Greece that developed a network of geotrails and featured many sites of special interest in terms of geology, volcanology and geoarchaeology. This study proposes an original georoute through land and sea, which aims t? emerge both overland and underwater areas of special interest. It is a novel way to approach the geological and cultural wealth of Milos and focuses on the Aghia Kiriaki area, at the South part of the island. This alternative georoute includes hiking, kayaking and snorkeling, and anyone who follows it, can be guided to a significant number of important geological, volcanic, morphological and geoarcheological sites, in a relatively narrow area, combining athletic activities as well. The proposed georoute has a total length of 3,2 km and an estimated time of completion of about 4 hours. It starts from Aghia Kiriaki area, where visitors can see remnants of one of the island's collapsed calderic domes in a panoramic view towards the East. In the same site, volcanic emanations create impressive scenery, which introduces the participants to aspects of the island's geologic and volcanic history. After about 800 meters of hiking, throughout an area that is dominated by products of phreatic eruptions, Aghia Kiriaki beach is the next stop. Impressive findings of

  20. Alternative approaches of SiC and related wide bandgap materials in light emitting and solar cell applications

    International Nuclear Information System (INIS)

    Materials for optoelectronics give a fascinating variety of issues to consider. Increasingly important are white light emitting diode (LED) and solar cell materials. Profound energy savings can be done by addressing new materials. White light emitting diodes are becoming common in our lighting scene. There is a great energy saving in the transition from the light bulb to white light emitting diodes via a transition of fluorescent light tubes. However, the white LEDs still suffer from a variety of challenges in order to be in our daily use. Therefore there is a great interest in alternative lighting solutions that could be part of our daily life. All materials create challenges in fabrication. Defects reduce the efficiency of optical transitions involved in the light emitting diode materials. The donor-acceptor co-doped SiC is a potential light converter for a novel monolithic all-semiconductor white LED. In spite of considerable research, the internal quantum efficiency is far less than theoretically predicted and is likely a fascinating scientific field for studying materials growth, defects and optical transitions. Still, efficient Si-based light source represents an ongoing research field in photonics that requires high efficiency at room temperature, wavelength tuning in a wide wavelength range, and easy integration in silicon photonic devices. In some of these devices, rare earth doped materials is considered as a potential way to provide luminescence spanning in a wide wavelength range. Divalent and trivalent oxidation states of Eu provide emitting centers in the visible region. In consideration, the use of Eu in photonics requires Eu doped thin films that are compatible with CMOS technology but for example faces material science issues like a low Eu solid solubility in silica. Therefore approaches aim to obtain efficient light emission from silicon oxycarbide which has a luminescence in the visible range and can be a host material for rare earth ions. The

  1. A numerical-statistical approach to determining the representative elementary volume (REV of cement paste for measuring diffusivity

    Directory of Open Access Journals (Sweden)

    Zhang, M. Z.

    2010-12-01

    Full Text Available Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV, in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First, several series of 3D cement paste microstructures were generated with HYMOSTRUC3D, a cement hydration and microstructure model, for different volumes of cement paste and w/c ratios ranging from 0.30 to 0.60. Second, the finite element method was used to simulate the diffusion of tritiated water through these microstructures. Effective cement paste diffusivity values for different REVs were obtained by applying Fick’s law. Finally, statistical analysis was used to find the fluctuation in effective diffusivity with cement paste volume, from which the REV was then determined. The conclusion drawn was that the REV for measuring diffusivity in cement paste is 100x100x100 μm3.

    La difusividad del hormigón depende de su microestructura a numerosas escalas, desde nanómetros hasta milímetros, por lo que se precisa de técnicas multiescala para representar este parámetro. Junto con el principio de homogeneización, uno de los métodos multiescala más habituales es el volumen elemental representativo (VER. El objeto de este estudio era establecer un procedimiento que permitiera determinar el VER necesario para calcular la difusividad de la pasta de cemento, basándose en un método numéricoestadístico que consta de tres etapas. Primero, se crearon varias series de microestructuras de pasta de cemento en 3D con HYMOSTRUC3D, un programa que permite crear un modelo de la hidratación y microestructura del cemento. Luego se empleó el método de

  2. Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

    International Nuclear Information System (INIS)

    Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multi pinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target's radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals. (author)

  3. Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Mejia, J.; Galvis-Alonso, O.Y. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Faculdade de Medicina. Dept. de Biologia Molecular], e-mail: mejia_famerp@yahoo.com.br; Braga, J. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Div. de Astrofisica; Correa, R. [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Div. de Ciencia Espacial e Atmosferica; Leite, J.P. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Neurologia, Psiquiatria e Psicologia Medica; Simoes, M.V. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Clinica Medica

    2009-08-15

    Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multi pinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target's radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals. (author)

  4. Final programmatic environmental impact statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 1: Main text

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky, Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. DOE's preferred alternative is to begin conversion of the depleted UF6 inventory as soon as possible, either to uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible

  5. An Alternative Approach to the Extraction of Structure Functions in Deep Inelastic e-p Scattering at 5 to 20 GeV

    Institute of Scientific and Technical Information of China (English)

    N. Ghahramany; M. Nouri

    2003-01-01

    Two structure functions W1(x,Q2) and W2(x,Q2) are determined by using the cross sections measured in the deep inelastic electron-proton scattering experiments at Stanford Linac in the energy range of 5 to 20 GeV. In this paper an alternative mathematical approach have been used in such determination, resulting in a larger number of points in the graphs of the structure functions.

  6. Using Alternative Approaches to Prioritize Testing for the Universe of Chemicals with Potential for Human Exposure (WC9)

    Science.gov (United States)

    One use of alternative methods is to target animal use at only those chemicals and tests that are absolutely necessary. We discuss prioritization of testing based on high-throughput screening assays (HTS), QSAR modeling, high-throughput toxicokinetics (HTTK), and exposure modelin...

  7. A Behavioral Perspective of Childhood Trauma and Attachment Issues: Toward Alternative Treatment Approaches for Children with a History of Abuse

    Science.gov (United States)

    Prather, Walter; Golden, Jeannie A.

    2009-01-01

    Attachment theory provides a useful conceptual framework for understanding trauma and the treatment of children who have been abused. This article examines childhood trauma and attachment issues from the perspective of behavior analysis, and provides a theoretical basis for two alternative treatment models for previously abused children and their…

  8. Regional Seminar on Alternative Approaches to School Education at Primary Level (Manila, 6-14 December, 1976). Final Report.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and Oceania.

    This paper represents the final report of a regional seminar (Asian countries) on educational alternatives held under the auspices of UNESCO in December 1976. The seminar focused on educational services for children from 5 to 14 years of age and emphasized the needs of children in poverty areas. Limitations and inequities in the current…

  9. Approaches of output improvement for a cesium vapor laser pumped by a volume-Bragg-grating coupled laser-diode-array

    International Nuclear Information System (INIS)

    We report the approaches of output improvement for a cesium vapor laser, which was pumped by a volume-Bragg-grating (VBG) coupled broad-area laser-diode-array (LDA) with the quasi-continuous-wave (QCW) drive mode, in adopting an appropriate heating procedure and improving the pump configuration

  10. A virtual repository approach to clinical and utilization studies: application in mammography as alternative to a national database.

    OpenAIRE

    Ohno-Machado, L.; Boxwala, A. A.; Ehresman, J.; Smith, D N; Greenes, R. A.

    1997-01-01

    A national mammography database was proposed, based on a centralized architecture for collecting, monitoring, and auditing mammography data. We have developed an alternative architecture relying on Internet-based distributed queries to heterogeneous databases. This architecture creates a "virtual repository", or a federated database which is constructed dynamically, for each query and makes use of data available in legacy systems. It allows the construction of custom-tailored databases at ind...

  11. An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.

    OpenAIRE

    Xiao-Tong Song; Kevin Evel-Kabler; Lisa Rollins; Melissa Aldrich; Feng Gao; Xue F Huang; Si-Yi Chen

    2006-01-01

    BACKGROUND: Current efforts to develop HIV vaccines that seek to stimulate immune responses have been disappointing, underscoring the inability of natural immune responses to control HIV-1 infection. Here we tested an alternative strategy to induce anti-HIV immune responses by inhibiting a host's natural immune inhibitor. METHODS AND FINDINGS: We used small interfering RNA (siRNA) to inhibit suppressor of cytokine signaling (SOCS) 1, a key negative regulator of the JAK/STAT pathway, and inves...

  12. Subsistence farmer preferences for alternative incentive policies to encourage the adoption of conservation agriculture in Malawi: A choice elicitation approach

    OpenAIRE

    Marenya, Paswel Phiri; Smith, Vincent H.; Nkonya, Ephraim M.

    2012-01-01

    Land degradation in most sub Saharan Africa is a widely recognized problem and is due in large part to poor land management practices. To address this problem, several policy-based incentives to increase the adoption of better land management practices have been proposed, including fertilizer subsidies, cash payments and, more recently, subsidized or commercially offered weather index-based insurance contracts. However, little is known about farmers’ preferences among these policy alternative...

  13. Alternative Supply Chain Production-Sales Policies for New Product Diffusion: An Agent-Based Modeling and Simulation Approach

    OpenAIRE

    Amini, Mehdi; Wakolbinger, Tina; Racer, Michael; Nejad, Mohammed G.

    2012-01-01

    Applying Agent-Based Modeling and Simulation (ABMS) methodology, this paper analyzes the impact of alternative production-sales policies on the diffusion of a new product and the generated NPV of profit. The key features of the ABMS model, that captures the marketplace as a complex adaptive system, are: (i) supply chain capacity is constrained; (ii) consumers' new product adoption decisions are influenced by marketing activities as well as positive and negative word of mouth (W...

  14. Space shuttle/food system. Volume 2, Appendix C: Food cooling techniques analysis. Appendix D: Package and stowage: Alternate concepts analysis

    Science.gov (United States)

    1974-01-01

    The relative penalties associated with various techniques for providing an onboard cold environment for storage of perishable food items, and for the development of packaging and vehicle stowage parameters were investigated in terms of the overall food system design analysis of space shuttle. The degrees of capability for maintaining both a 40 F to 45 F refrigerated temperature and a 0 F and 20 F frozen environment were assessed for the following cooling techniques: (1) phase change (heat sink) concept; (2) thermoelectric concept; (3) vapor cycle concept; and (4) expendable ammonia concept. The parameters considered in the analysis were weight, volume, and spacecraft power restrictions. Data were also produced for packaging and vehicle stowage parameters which are compatible with vehicle weight and volume specifications. Certain assumptions were made for food packaging sizes based on previously generated space shuttle menus. The results of the study are shown, along with the range of meal choices considered.

  15. A Vector Approach to Euclidean Geometry: Inner Product Spaces, Euclidean Geometry and Trigonometry, Volume 2. Teacher's Edition.

    Science.gov (United States)

    Vaughan, Herbert E.; Szabo, Steven

    This is the teacher's edition of a text for the second year of a two-year high school geometry course. The course bases plane and solid geometry and trigonometry on the fact that the translations of a Euclidean space constitute a vector space which has an inner product. Congruence is a geometric topic reserved for Volume 2. Volume 2 opens with an…

  16. Quantitative Imaging Assessment of an Alternative Approach to Surgical Mitral Valve Leaflet Resection: An Acute Porcine Study.

    Science.gov (United States)

    Boronyak, Steven M; Fredi, Joseph L; Young, Michael N; Dumont, Douglas M; Williams, Phillip E; Byram, Brett C; Merryman, W David

    2016-07-01

    This study reports the initial in vivo use of a combined radiofrequency ablation and cryo-anchoring (RFC) catheter as an alternative to surgical mitral valve (MV) leaflet resection. Radiofrequency ablation thermally shrinks enlarged collagenous tissues, providing an alternative to leaflet resection, and cryo-anchoring provides reversible attachment of a catheter to freely mobile MV leaflets. Excised porcine MVs (n = 9) were tested in a left heart flow simulator to establish treatment efficacy criteria. Resected leaflet area was quantified by tracking markers on the leaflet surface, and leaflet length reductions were directly measured on echocardiography. Leaflet area decreased by 38 ± 2.7%, and leaflet length decreased by 9.2 ± 1.8% following RFC catheter treatment. The RFC catheter was then tested acutely in healthy pigs (n = 5) under epicardial echocardiographic guidance, open-chest without cardiopulmonary bypass, using mid-ventricular free wall access. Leaflet length was quantified using echocardiography. Quantitative assessment of MV leaflet length revealed that leaflet resection was successful in 4 of 5 pigs, with a leaflet length reduction of 13.3 ± 4.6%. Histological, mechanical, and gross pathological findings also confirmed that RFC catheter treatment was efficacious. The RFC catheter significantly reduces MV leaflet size in an acute animal model, providing a possible percutaneous alternative to surgical leaflet resection. PMID:26508331

  17. Teacher Beliefs toward Using Alternative Teaching Approaches in Science and Mathematics Classes Related to Experience in Teaching

    Science.gov (United States)

    Isiksal-Bostan, Mine; Sahin, Elvan; Ertepinar, Hamide

    2015-01-01

    The purpose of this study was to examine the relationships among Turkish classroom, science and mathematics teachers' beliefs toward using inquiry-based approaches, traditional teaching approaches, and technology in their mathematics and science classrooms; their efficacy beliefs in teaching those subjects; and years of experience in teaching in…

  18. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Volume III explores resources and fuel cycle facilities. Chapters are devoted to: estimates of US uranium resources and supply; comparison of US uranium demands with US production capability forecasts; estimates of foreign uranium resources and supply; comparison of foreign uranium demands with foreign production capability forecasts; and world supply and demand for other resources and fuel cycle services. An appendix gives uranium, fissile material, and separative work requirements for selected reactors and fuel cycles.

  19. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    International Nuclear Information System (INIS)

    Volume III explores resources and fuel cycle facilities. Chapters are devoted to: estimates of US uranium resources and supply; comparison of US uranium demands with US production capability forecasts; estimates of foreign uranium resources and supply; comparison of foreign uranium demands with foreign production capability forecasts; and world supply and demand for other resources and fuel cycle services. An appendix gives uranium, fissile material, and separative work requirements for selected reactors and fuel cycles

  20. Alternative method for volumetric core removal in hardsetting soils Método alternativo para a retirada de anéis volumétricos em solos coesos

    OpenAIRE

    Herdjania Veras de Lima; Álvaro Pires da Silva; Sílvia Imhoff; Afrânio Ferreira Neves Junior

    2005-01-01

    Due to the narrow window of ideal moisture conditions required for collecting undisturbed soil samples from hardsetting horizons in the field, this study compared the efficiency of an alternative method of soil core removal in the laboratory with that of the traditional field method by using measurements of soil bulk density data (Db). In a first sampling, cylinders were removed with a soil sampler in the field. In a second sampling, large soil blocks were removed with Kubiena-type zinc (bras...

  1. Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

    International Nuclear Information System (INIS)

    The development of non-animal testing methods for the assessment of skin sensitisation potential is an urgent challenge within the framework of existing and forthcoming legislation. Efforts have been made to replace current animal tests, but so far no alternative methods have been developed. It is widely recognised that alternatives to animal testing cannot be accomplished with a single approach, but rather will require the integration of results obtained from different in vitro and in silico assays. The argument subjacent to the development of in vitro dendritic cell (DC)-based assays is that sensitiser-induced changes in the DC phenotype can be differentiated from those induced by irritants. This assumption is derived from the unique capacity of DC to convert environmental signals encountered at the skin into a receptor expression pattern (MHC class II molecules, co-stimulatory molecules, chemokine receptors) and a soluble mediator release profile that will stimulate T lymphocytes. Since signal transduction cascades precede changes in surface marker expression and cytokine/chemokine secretion, these phenotypic modifications are a consequence of a signal transduction profile that is specifically triggered by sensitisers and not by irritants. A limited number of studies have addressed this subject and the present review attempts to summarise and highlight all of the signalling pathways modulated by skin sensitisers and irritants. Furthermore, we conclude this review by focusing on the most promising strategies suitable for inclusion into a cell-based in vitro alternative approach to hazard identification.

  2. Numerical modelling in building thermo-aeraulics: from CFD modelling to an hybrid finite volume / zonal approach; Modelisation numerique de la thermoaeraulique du batiment: des modeles CFD a une approche hybride volumes finis / zonale

    Energy Technology Data Exchange (ETDEWEB)

    Bellivier, A.

    2004-05-15

    For 3D modelling of thermo-aeraulics in building using field codes, it is necessary to reduce the computing time in order to model increasingly larger volumes. The solution suggested in this study is to couple two modelling: a zonal approach and a CFD approach. The first part of the work that was carried out is the setting of a simplified CFD modelling. We propose rules for use of coarse grids, a constant effective viscosity law and adapted coefficients for heat exchange in the framework of building thermo-aeraulics. The second part of this work concerns the creation of fluid Macro-Elements and their coupling with a calculation of CFD finite volume type. Depending on the boundary conditions of the problem, a local description of the driving flow is proposed via the installation and use of semi-empirical evolution laws. The Macro-Elements is then inserted in CFD computation: the values of velocity calculated by the evolution laws are imposed on the CFD cells corresponding to the Macro-Element. We use these two approaches on five cases representative of thermo-aeraulics in buildings. The results are compared with experimental data and with traditional RANS simulations. We highlight the significant gain of time that our approach allows while preserving a good quality of numerical results. (author)

  3. Genefish: an alternate metagenomic approach for capturing targeted bacterial diversity in an engineered recipient E. coli strain

    OpenAIRE

    Lombard, Nathalie; Faugier, Aurélie; Lavire, Céline; Jacquiod, Samuel; Philippot, Laurent; Zhang, Xiaojun; Lazzaroni, Jean-Claude; Simonet, Pascal; Franqueville, Laure

    2009-01-01

    The metagenomic approach, defined as the direct recovery and cloning of bacterial DNA from the environment in domesticated bacterial hosts has been widely used to study bacterial populations and their functional genes in numerous environments. The advantage of this approach over conventional culture based techniques is that it encompasses a wider range of bacteria by bypassing the bias of uncultivability of more than 99% of the bacteria in soil. However, in complex and rich environments such ...

  4. A Hybrid Approach Using ISM For Leveling Agile Criteria And Fuzzy AHP To Determine The Relative Weights Of Evaluation Criteria And Fuzzy TOPSIS To Rank The Alternatives

    Directory of Open Access Journals (Sweden)

    Mahdi Karbasian1

    2012-02-01

    Full Text Available In today’s organizations, performance measurement comes more to the foreground with the advancement in the high technology. Supplier selection is an important issue in supply chain management. In recent years, determining the best supplier in the supply chain has become a key strategic consideration. However, these decisions usually involve several objectives or criteria, and it is often necessary to compromise among possibly conflicting factors. Thus, the multiple criteria decision making (MCDM becomes a useful approach to solve this kind of problem. In order to use the conceptual framework for measuring performance supplier, a methodology that takes into account both quantitative and qualitative factors and the interrelations between them should be utilized. for leveling an integrated approach of analytic hierarchy process AHP and fuzzy TOPSIS method is proposed to obtain final ranking. The interactions among the criteria are also analyzed before arriving at a decision for the selection of supplier from among six alternatives. Linguistic values are used to assess the ratings and weights for criterion. These linguistic ratings can be expressed in triangular fuzzy numbers. Then, a hierarchy multiple criteria decision-making (MCDM model based on fuzzy-sets theory including FAHP and FTOPSIS are applied. There are two approaches for aggregating values including relative importance of evaluation criteria with respect to the overall objective and rating of alternatives with respect to each criterion in fuzzy group TOPSIS: First aggregation and Last aggregation. In first aggregation approach weight of each criterion and rating of alternatives with respect to each criterion gained from decision makers are aggregated at first and TOPSIS method then apply to these aggregate values. In last aggregation approach weight of each criterion and rating of alternatives with respect to each criterion gained from decision makers are used in TOPSIS method

  5. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle description

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates.

  6. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle description

    International Nuclear Information System (INIS)

    The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates

  7. A virtual repository approach to clinical and utilization studies: application in mammography as alternative to a national database.

    Science.gov (United States)

    Ohno-Machado, L; Boxwala, A A; Ehresman, J; Smith, D N; Greenes, R A

    1997-01-01

    A national mammography database was proposed, based on a centralized architecture for collecting, monitoring, and auditing mammography data. We have developed an alternative architecture relying on Internet-based distributed queries to heterogeneous databases. This architecture creates a "virtual repository", or a federated database which is constructed dynamically, for each query and makes use of data available in legacy systems. It allows the construction of custom-tailored databases at individual sites that can serve the dual purposes of providing data (a) to researchers through a common mammography repository and (b) to clinicians and administrators at participating institutions. We implemented this architecture in a prototype system at the Brigham and Women's Hospital to show its feasibility. Common queries are translated dynamically into database-specific queries, and the results are aggregated for immediate display or download by the user. Data reside in two different databases and consist of structured mammography reports, coded per BIRADS Standardized Mammography Lexicon, as well as pathology results. We prospectively collected data on 213 patients, and showed that our system can perform distributed queries effectively. We also implemented graphical exploratory analysis tools to allow visualization of results. Our findings indicate that the architecture is not only feasible, but also flexible and scaleable, constituting a good alternative to a national mammography database. PMID:9357650

  8. Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.

    Science.gov (United States)

    Chaikuad, Apirat; Knapp, Stefan; von Delft, Frank

    2015-08-01

    The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially available crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant. PMID:26249344

  9. Alternative methods for disposal of low-level radioactive wastes. Volume 3. Task 2b: technical requirements for aboveground vault disposal of low-level radioactive waste

    International Nuclear Information System (INIS)

    The study reported herein contains the results of Task 2b (Technical Requirements for Aboveground Vault Disposal of Low-Level Radioactive Waste) of a four-task study entitled ''Criteria for Evaluating Engineered Facilities.'' The overall objective of this study is to ensure that the criteria needed to evaluate five alternative low-level radioactive waste (LLW) disposal methods are available potential license applicants. The above-ground vault disposal alternative is one of several methods that may be proposed for disposal of low-level radioactive waste. In this report, the term aboveground vault refers to an engineered structure with roof, walls and floor enclosing the disposal space. The limited experience and knowledge gained with this method are described and updated in this report. The short term experience does not conclusively demonstrate the capability of this method to satisfy the Part 61 Performance Objectives. A generic description of the features and components and operation of an aboveground vault disposal facility is provided. Features and components that could enhance the long-term performance are described. The applicability of existing criteria developed for near-surface disposal (10 CFR Part 61 Subpart D) to the aboveground vault disposal method, as assessed in Task 1, are reassessed herein. With few exceptions, these criteria were found to be applicable in the reassessment. These conclusions differ slightly from the Task 1 findings. 22 refs., 5 figs

  10. Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens

    Energy Technology Data Exchange (ETDEWEB)

    Chaikuad, Apirat, E-mail: apirat.chaikuad@sgc.ox.ac.uk [University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ (United Kingdom); Knapp, Stefan [University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ (United Kingdom); Johann Wolfgang Goethe-University, Building N240 Room 3.03, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main (Germany); Delft, Frank von, E-mail: apirat.chaikuad@sgc.ox.ac.uk [University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ (United Kingdom)

    2015-07-28

    An alternative strategy for PEG sampling is suggested through the use of four newly defined PEG smears to enhance chemical space in reduced screens with a benefit towards protein crystallization. The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially available crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant.

  11. Seven competing ways to recover the Michaelis-Menten equation reveal the alternative approaches to steady state modeling

    CERN Document Server

    Michel, Denis

    2013-01-01

    The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Seven methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.

  12. DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences

    Directory of Open Access Journals (Sweden)

    Gaëlle Lenglet

    2010-01-01

    Full Text Available DNA targeting drugs represent a large proportion of the actual anticancer drug pharmacopeia, both in terms of drug brands and prescription volumes. Small DNA-interacting molecules share the ability of certain proteins to change the DNA helix's overall organization and geometrical orientation via tilt, roll, twist, slip, and flip effects. In this ocean of DNA-interacting compounds, most stabilize both DNA strands and very few display helix-destabilizing properties. These types of DNA-destabilizing effect are observed with certain mono- or bis-intercalators and DNA alkylating agents (some of which have been or are being developed as cancer drugs. The formation of locally destabilized DNA portions could interfere with protein/DNA recognition and potentially affect several crucial cellular processes, such as DNA repair, replication, and transcription. The present paper describes the molecular basis of DNA destabilization, the cellular impact on protein recognition, and DNA repair processes and the latter's relationships with antitumour efficacy.

  13. Alternative security

    International Nuclear Information System (INIS)

    This book contains the following chapters: The Military and Alternative Security: New Missions for Stable Conventional Security; Technology and Alternative Security: A Cherished Myth Expires; Law and Alternative Security: Toward a Just World Peace; Politics and Alternative Security: Toward a More Democratic, Therefore More Peaceful, World; Economics and Alternative Security: Toward a Peacekeeping International Economy; Psychology and Alternative Security: Needs, Perceptions, and Misperceptions; Religion and Alternative Security: A Prophetic Vision; and Toward Post-Nuclear Global Security: An Overview

  14. An alternative approach to monitoring fish and fish habitat in the inland Northwest: Annual report 1999; ANNUAL

    International Nuclear Information System (INIS)

    The development of efficient and effective monitoring protocols will depend, in part, upon successfully incorporating multiple research and management goals across several disciplines. Decision analysis has these abilities and can be used to examine the potential effects of alternative management activities, identify candidate monitoring variables, and estimate the value of monitoring or conducting additional studies. The author demonstrates the utility of decision analysis for monitoring and adaptive (i.e., experimental) management with an example of a timber harvest decision. Example models were generated using previously reported relationships and Monte Carlo simulation and the value of sampling (e.g., monitoring) was estimated via Baye's Rule. He concludes that the decision analysis can be a powerful tool for developing a future effectiveness monitoring protocols and should be considered by natural resource managers prior to adopting a monitoring strategy

  15. DNA-synthesis inhibition and repair DNA-synthesis in CHO Ade- C cells: An alternative approach to genotoxicity testing

    International Nuclear Information System (INIS)

    We describe an alternative assay to determine genotoxicity. Its main feature is that it combines two measures in a single experiment; the inhibition of replicative DNA synthesis together with the stimulation of DNA repair. We show that, in tests of four different genotoxic agents, the assay gives results that are entirely consistent with what is known about the mode of action of these agents. In addition, we have demonstrated that chemical carcinogens requiring metabolic activation can be examined using a standard procedure of incubation with a microsomal activating fraction. We consider the combined assay for DNA synthesis inhibition and repair synthesis to be a useful way for the rapid pre-screening of chemicals suspected of genotoxic activity on the level of mammalian cells. (author)

  16. An alternative discourse of productive aging: A self-restrained approach in older Chinese people in Hong Kong.

    Science.gov (United States)

    Luo, Minxia; Chui, Ernest Wing-Tak

    2016-08-01

    While Western discourses regarding productive aging emphasize individuals' contributions to economic productivity, the Confucian cultural heritage of the Chinese community may provide an alternative perspective. This qualitative study explores interpretations of what constitutes productive aging, based on a series of in-depth interviews with older Chinese people in Hong Kong. It shows that some of these individuals adopted a passive and indirect interpretation of productive aging, distinct from that found in Western countries. The Confucianism-based, collectivist, normative order underpinning Hong Kong society disposed these older people to adopting a self-restrained attitude with the aim of avoiding becoming a burden to others, especially family members. Such a tendency toward self-restraint or avoidance also encompassed a compromise between ideals and reality, with the older people opting to compromise their expectations of the younger generation as a whole, their adult children in particular, in terms of respect and reciprocity. PMID:27531450

  17. Predicting the diffusion coefficient of water vapor through glassy HPMC films at different environmental conditions using the free volume additivity approach.

    Science.gov (United States)

    Laksmana, Fesia Lestari; Hartman Kok, Paul Jean Antoine; Vromans, Herman; Van der Voort Maarschalk, Kees

    2009-07-12

    Prediction of diffusion coefficient of polymer materials is important in the pharmaceutical research and becomes the aim of this paper. This paper bases the prediction method on the estimation of the polymer fractional free volume at different environmental conditions. Focussing on glassy polymers, the free volumes of polymer films were estimated using the model of Vrentas et al. [J.S. Vrentas, J.L. Duda, H.-C. Ling, Antiplasticization and volumetric behavior in glassy polymers, Macromolecules 21 (1988) 1470-1475]. The required data are the moisture sorption and glass transition temperature data, which were measured on various hydroxypropyl methylcellulose (used as a model material) free films at different water activities. The temperature and molecular weight particularly determine the free volume of the polymer, while the sorbed water can either decrease or increase the specific free volume of the polymer. At high water activity, the amount of water sorbed in the film increases to such level that the direct free volume addition by water becomes proportional to the contribution of the polymer itself. This confirms the importance of considering the environmental effect on the diffusivity of polymer during coating material selection. The presented approach enables the prediction of the diffusivity at any given relevant material variable and therefore has the potency to be used as a formulation development tool. PMID:19409985

  18. An Alternative and Effective HIV Vaccination Approach Based on Inhibition of Antigen Presentation Attenuators in Dendritic Cells.

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available BACKGROUND: Current efforts to develop HIV vaccines that seek to stimulate immune responses have been disappointing, underscoring the inability of natural immune responses to control HIV-1 infection. Here we tested an alternative strategy to induce anti-HIV immune responses by inhibiting a host's natural immune inhibitor. METHODS AND FINDINGS: We used small interfering RNA (siRNA to inhibit suppressor of cytokine signaling (SOCS 1, a key negative regulator of the JAK/STAT pathway, and investigated the effect of this silencing on the ability of dendritic cells (DCs to induce anti-HIV-1 immunity. We found that SOCS1-silenced DCs broadly induced enhanced HIV-1 envelope (Env-specific CD8(+ cytotoxic T lymphocytes and CD4(+ T helper cells, as well as antibody responses, in mice. Importantly, SOCS1-silenced DCs were more resistant to HIV Env-mediated suppression and were capable of inducing memory HIV Env-specific antibody and T cell responses. SOCS1-restricted signaling, as well as production of proinflammatory cytokines such as interleukin-12 by DCs, play a critical role in regulating the anti-HIV immune response. Furthermore, the potency of HIV DNA vaccination is significantly enhanced by coimmunization with SOCS1 siRNA expressor DNA. CONCLUSIONS: This study demonstrates that SOCS1 functions as an antigen presentation attenuator to control both HIV-1-specific humoral and cellular responses. This study represents the first, to our knowledge, attempt to elicit HIV-specific T cell and antibody responses by inhibiting a host's antigen presentation attenuator, which may open a new and alternative avenue to develop effective therapeutic and prophylactic HIV vaccines.

  19. The Civic-Minded Instructional Designers Framework: An Alternative Approach to Contemporary Instructional Designers' Education in Higher Education

    Science.gov (United States)

    Yusop, Farrah Dina; Correia, Ana-Paula

    2012-01-01

    This paper argues that an emphasis on training-for-the-job approaches has distracted designers from thinking about the meaning of their profession and the grand purpose of practising instructional design. Drawing from literature in the fields of sociology and educational technology, this paper synthesises discourses on civic professionalism in…

  20. Measuring population health: costs of alternative survey approaches in the Nouna Health and Demographic Surveillance System in rural Burkina Faso

    Directory of Open Access Journals (Sweden)

    Henrike Lietz

    2015-08-01

    Full Text Available Background: There are more than 40 Health and Demographic Surveillance System (HDSS sites in 19 different countries. The running costs of HDSS sites are high. The financing of HDSS activities is of major importance, and adding external health surveys to the HDSS is challenging. To investigate the ways of improving data quality and collection efficiency in the Nouna HDSS in Burkina Faso, the stand-alone data collection activities of the HDSS and the Household Morbidity Survey (HMS were integrated, and the paper-based questionnaires were consolidated into a single tablet-based questionnaire, the Comprehensive Disease Assessment (CDA. Objective: The aims of this study are to estimate and compare the implementation costs of the two different survey approaches for measuring population health. Design: All financial costs of stand-alone (HDSS and HMS and integrated (CDA surveys were estimated from the perspective of the implementing agency. Fixed and variable costs of survey implementation and key cost drivers were identified. The costs per household visit were calculated for both survey approaches. Results: While fixed costs of survey implementation were similar for the two survey approaches, there were considerable variations in variable costs, resulting in an estimated annual cost saving of about US$45,000 under the integrated survey approach. This was primarily because the costs of data management for the tablet-based CDA survey were considerably lower than for the paper-based stand-alone surveys. The cost per household visit from the integrated survey approach was US$21 compared with US$25 from the stand-alone surveys for collecting the same amount of information from 10,000 HDSS households. Conclusions: The CDA tablet-based survey method appears to be feasible and efficient for collecting health and demographic data in the Nouna HDSS in rural Burkina Faso. The possibility of using the tablet-based data collection platform to improve the quality

  1. Design Concept for a Minimal Volume Spacecraft Cabin to Serve as a Mars Ascent Vehicle Cabin and Other Alternative Pressurized Vehicle Cabins

    Science.gov (United States)

    Howard, Robert L., Jr.

    2016-01-01

    The Evolvable Mars Campaign is developing concepts for human missions to the surface of Mars. These missions are round-trip expeditions, thereby requiring crew launch via a Mars Ascent Vehicle (MAV). A study to identify the smallest possible pressurized cabin for this mission has developed a conceptual vehicle referred to as the minimal MAV cabin. The origin of this concept will be discussed as well as its initial concept definition. This will lead to a description of possible configurations to integrate the minimal MAV cabin with ascent vehicle engines and propellant tanks. Limitations of this concept will be discussed, in particular those that argue against the use of the minimal MAV cabin to perform the MAV mission. However, several potential alternative uses for the cabin are identified. Finally, recommended forward work will be discussed, including current work in progress to develop a full scale mockup and conduct usability evaluations.

  2. The play approach to learning in the context of families and schools: an alternative paradigm for nutrition and fitness education in the 21st century.

    Science.gov (United States)

    Rickard, K A; Gallahue, D L; Gruen, G E; Tridle, M; Bewley, N; Steele, K

    1995-10-01

    An alternative paradigm for nutrition and fitness education centers on understanding and developing skill in implementing a play approach to learning about healthful eating and promoting active play in the context of the child, the family, and the school. The play approach is defined as a process for learning that is intrinsically motivated, enjoyable, freely chosen, nonliteral, safe, and actively engaged in by young learners. Making choices, assuming responsibility for one's decisions and actions, and having fun are inherent components of the play approach to learning. In this approach, internal cognitive transactions and intrinsic motivation are the primary forces that ultimately determine healthful choices and life habits. Theoretical models of children's learning--the dynamic systems theory and the cognitive-developmental theory of Jean Piaget--provide a theoretical basis for nutrition and fitness education in the 21st century. The ultimate goal is to develop partnerships of children, families, and schools in ways that promote the well-being of children and translate into healthful life habits. The play approach is an ongoing process of learning that is applicable to learners of all ages. PMID:7560683

  3. Climate. For a successful change. Volume 1: How to commit one's territory in an adaptation approach. Volume 2: How to implement a territorial project which integrates adaptation. Volume 3: How to understand the complexity of climate change - Scientific issues

    International Nuclear Information System (INIS)

    The first volume presents the climate issue as a world issue as well as a local issue (historic context of adaptation to climate change effects, legal obligation for local communities, indicators of direct and indirect effects of climate change, economic impacts), and presents adaptation as a way of action at a local level (definition of a strategy, articulation between works on greenhouse gas emissions and those on adaptation, actions to be implemented, action follow-up and adjustment). The second volume describes how to communicate and talk about climate change, and more specifically about the above-mentioned issues (reality of climate change, indirect and direct effects, obligations and responsibilities for local communities, economic impacts). It addresses the issue of climate change in the Rhone-Alpes region: adaptation within the regional scheme on climate, air and energy (SRCAE), role of local communities. It presents an action methodology: to inform and organise, to prepare the mobilisation of actors, to prepare the territory vulnerability diagnosis, to define the adaptation strategy, and to implement, follow-up and assess the action. The third volume proposes a set of sheets containing scientific information and data related to climate change: factors of climate variability, current global warming, greenhouse gases and aerosols, physical-chemical principles involved in greenhouse effect, carbon sinks and carbon sources, effects of land assignment and agriculture, combined effects of mankind actions on the atmosphere, climate change and oceans, climate change and cryo-sphere, climate change and biodiversity, extreme meteorological and climate events and their consequences

  4. An Alternative Canonical Approach to the Ghost Problem in a Complexified Extension of the Pais-Uhlenbeck Oscillator

    CERN Document Server

    Déctor, A; Urrutia, L F; Vergara, J D; 10.3842/SIGMA.2009.053

    2009-01-01

    Our purpose in this paper is to analyze the Pais-Uhlenbeck (PU) oscillator using complex canonical transformations. We show that starting from a Lagrangian approach we obtain a transformation that makes the extended PU oscillator, with unequal frequencies, to be equivalent to two standard second order oscillators which have the original number of degrees of freedom. Such extension is provided by adding a total time derivative to the PU Lagrangian together with a complexification of the original variables further subjected to reality conditions in order to maintain the required number of degrees of freedom. The analysis is accomplished at both the classical and quantum levels. Remarkably, at the quantum level the negative norm states are eliminated, as well as the problems of unbounded below energy and non-unitary time evolution. We illustrate the idea of our approach by eliminating the negative norm states in a complex oscillator. Next, we extend the procedure to the Pais-Uhlenbeck oscillator. The correspondi...

  5. The clinical effectiveness of cognitive behavior therapy and an alternative medicine approach in reducing symptoms of depression in adolescents.

    Science.gov (United States)

    Charkhandeh, Mansoureh; Talib, Mansor Abu; Hunt, Caroline Jane

    2016-05-30

    The main aim of the study was to investigate the effectiveness of two psychotherapeutic approaches, cognitive behavioral therapy (CBT) and a complementary medicine method Reiki, in reducing depression scores in adolescents. We recruited 188 adolescent patients who were 12-17 years old. Participants were randomly assigned to CBT, Reiki or wait-list. Depression scores were assessed before and after the 12 week interventions or wait-list. CBT showed a significantly greater decrease in Child Depression Inventory (CDI) scores across treatment than both Reiki (pCBT and Reiki were effective in reducing the symptoms of depression over the treatment period, with effect for CBT greater than Reiki. These findings highlight the importance of early intervention for treatment of depression using both cognitive and complementary medicine approaches. However, research that tests complementary therapies over a follow-up period and against a placebo treatment is required. PMID:27058159

  6. Positive psychology as an alternative to traditional clinical approach to study of quality of life in people with physical disabilities

    OpenAIRE

    Lebedeva A. A.

    2012-01-01

    The article is devoted to overview studies of quality of life in people with physical disabilities. The scientists are mainly focused on the health limitations as affecting their quality of life. As a fact, disabled people need regular medical help, procedures of rehabilitation and prophylaxis of medical consequences of their disability. This paper addresses the subject from the perspective of positive approaches to development of personality and quality of life in people with disabilities. P...

  7. AN ALTERNATIVE APPROACH FOR CHILD LABOUR IN DEVELOPING COUNTRIES: CHILD LABOUR PARTICIPATION RATES OR SCHOOL NON-ATTENDANCE RATES

    OpenAIRE

    Ozcan Dagdemir; Hakan Acaroglu

    2010-01-01

    Child labour widely measured by child labour participation rates in literature is considered by non-attendance rates in primary education in this study. Along with this approach, it is attempted to investigate in what closeness the child labour ratios of countries are also measured by school non-attendance rates. The data is collected from UNICEF and World Bank. 85 developing countries take part in cross-country analysis by ordinary least square technique. The time period interval is 2000-200...

  8. ALTERNATIVE APPROACH IN THE TREATMENT OF A GINGIVAL CLEFT ASSOCIATED WITH LABIAL FRENULUM. A 3-YEAR FOLLOW-UP. (Case Report

    Directory of Open Access Journals (Sweden)

    Kamen Kotsilkov

    2015-07-01

    Full Text Available INTRODUCTION: The term Gingival cleft refers to a fissure in the gingival tissues and is usually caused by traumatic oral hygiene, abnormal frenula, trauma from occlusion, orthodontic, or pierce related trauma. Gingival clefts are classified depending on the extent of the inclusion of the gingival thickness into red and white. The recommended treatment approach for the incomplete white clefts is the gingivectomy of the affected keratinized tissue followed by a coronally advanced flap for the root coveradge, while the complete white clefts are treated with a laterally moved, coronally advanced flap, or a free gingival graft procedure. OBJECTIVE: This report presents a case with a spontaneous healing of an incomplete gingival cleft associated with a maxillary labial frenulum after an alternative frenuloectomy approach. METHODS: M.G. (45 with a localized chronic periodontitis, an abnormal papillary maxillary frenulum and an incomplete white cleft on the marginal gingiva of the left central incisor. An alternative frenuloectomy approach combined with a free gingival graft was selected for the correction of the abnormal frenulum. RESULTS:On the sixth month after the surgical procedure an almost complete recovery of the gingival margin was observed.The result at the third year demonstrates a stable gingival margin with a complete tissue recovery. CONCLUSION: The applied combined surgical approach led to a complete gingival recovery of the incomplete white gingival cleft without the commonly used gingivectomy and CAF. Further research is recommended to clarify the adjunctive benefits of the FGG in patients with gingival clefts associated with abnormal frenula.

  9. Promoting Community-based Extension Agents as an Alternative Approach to Formal Agricultural Extension Service Delivery in Northern Ghana

    Directory of Open Access Journals (Sweden)

    Samuel Z. Bonye

    2012-03-01

    Full Text Available The CBEA concept is an alternative to community-based extension intervention aimed at addressing the inadequacy of formal extension services provision to rural poor farmers of the Northern Regions of Ghana. The study sought to find out the extent to which the Community-Based Extension Agent has improved access to extension services to rural farmers. The study used qualitative and quantitative methods such as, Focus Group Discussions, Key Informants, In-depth interviews, Household and Institutional Questionnaires to collect and analyses data. The findings are that: there are vibrant Community Based Extension Agents established providing extension services in crop, livestock and environmental issues in the study District; farmers groups are linked to external agents and other stakeholders for access to credit facilities; the CBEAs were found to be the main link between the community and external agents; the most dominant extension services delivery carried out by the CBEAs in the entire study district were in crop production, livestock production and bushfire management; there are well established criteria for selecting Community Based Extension Agents, and community Based Extension Agents were least motivated. The study recommends among others that: motivation packages such as bicycles would facilitate the movement CBEAs to reach out to majority of the farmers. There is also the need to link CBEAs to relevant institutions/organizations for support and establishment of mechanisms to generate funds to support activities. Finally, stakeholders and organization need to intensify community sensitization and awareness creation on activities of CBEAs.

  10. Promoting Community-Based Extension Agents as an Alternative Approach to Formal Agricultural Extension Service Delivery in Northern Ghana

    Directory of Open Access Journals (Sweden)

    Samuel Z. Bonye

    2012-03-01

    Full Text Available The CBEA concept is an alternative to community-based extension intervention aimed at addressing the inadequacy of formal extension services provision to rural poor farmers of the Northern Regions of Ghana. The study sought to find out the extent to which the Community-Based Extension Agent has improved access to extension services to rural farmers. The study used qualitative and quantitative methods such as, Focus Group Discussions, Key Informants, In-depth interviews, Household and Institutional Questionnaires to collect and analyses data. The findings are that: there are vibrant Community Based Extension Agents established providing extension services in crop, livestock and environmental issues in the study District; farmers groups are linked to external agents and other stakeholders for access to credit facilities; the CBEAs were found to be the main link between the community and external agents; the most dominant extension services delivery carried out by the CBEAs in the entire study district were in crop production, livestock production and bushfire management; there are well established criteria for selecting Community Based Extension Agents, and community Based Extension Agents were least motivated. The study recommends among others that: motivation packages such as bicycles would facilitate the movement CBEAs to reach out to majority of the farmers. There is also the need to link CBEAs to relevant institutions/organizations for support and establishment of mechanisms to generate funds to support activities. Finally, stakeholders and organization need to intensify community sensitization and awareness creation on activities of CBEAs.

  11. Photodynamic therapy for angiosarcoma of scalp as alternative approach for surgical treatment in patient with severe co-morbidity

    Directory of Open Access Journals (Sweden)

    E. V. Yaroslavtseva-Isaeva

    2014-01-01

    Full Text Available A case of successful photodynamic therapy in patient of 86 y.o. with diagnosis: angiosarcoma of right temporal-parietal region stage IIA (Т2вN0M0 is reported. The tumor was as soft tissue round shape lesion with tuberous contours 3.4х3.4х1.1 cm in size, located in subcutaneous tissue in right parietal region with no scull bone invasion. The patient was refused to surgical treatment with general anesthesia due to severe cardiovascular co-morbidity. The patient underwent a course of photodynamic therapy with Photolon. The photosensitizer was intravenousely introduced for 3 h before irradiation at dose of 1 mg/kg body weight. The parameters of irradiation were as follows: output power – 0.8 W, light dose – 150 J/cm2, 4 irradiation fields 2.5 cm in diameter. During the irradiation there were moderate pain which did not require drug management. After PDT complete regression of the tumor was achieved. For nowadays (11 months after treatment the patient is observed with no recurrence. The reported case shows that photodynamic therapy may be successfully used for alternative treatment of soft tissue angiosarcoma in patients with no ability for surgical treatment. 

  12. Modification of the Newtonian Dynamics in ΛFRW-Cosmology an Alternative Approach to Dark Matter and Dark Energy

    Directory of Open Access Journals (Sweden)

    Nelson Falcón

    2013-08-01

    Full Text Available Modified Newtonian Dynamics (MoND is an empirically motivated modification of Newtonian gravity at largest scales, to explain rotation curves of galaxies, as an alternative to nonbaryonic dark matter. But MoND theories can hardly connect to the formalism of relativistic cosmology type Friedmann-Robertson-Walker. Presently work intends the existence of one scalar potential, with non gravitational origin, that would solve these problems. This potential Yukawa type inverse is build starting from a specular reflection of the potential of Yukawa: null in very near solar system, slightly attractiveness in ranges of interstellar distances, very attractiveness in distance ranges comparable to galaxies cluster and repulsive to cosmic scales. The consequences of this potential are discussed, through Cosmological Model Tipe Friedmann-Roberston-Walker with cosmological term in function of the distance (lambda like function of r. In the cosmological model so raised the critical density of matter is consistent with the observed density does not include dark matter, MoND theory is deduced for interstellar scales and consequently would explain rotation curves. Also it is shown that Yukawa type inverse does not alter the predictions of the Cosmic Microwave Background neither the primordial nucleosynthesis in early universe; and can be explain the large-scale structure formation.

  13. An Alternative Approach to Synthesizing Galactooligosaccharides by Cell-Surface Display of β-Galactosidase on Yarrowia lipolytica.

    Science.gov (United States)

    An, Jin; Zhang, Lebin; Li, Lijuan; Liu, Dawen; Cheng, Huiling; Wang, Hengwei; Nawaz, Muhammad Zohaib; Cheng, Hairong; Deng, Zixin

    2016-05-18

    An alternative strategy for synthesizing galactooligosaccharides (GOS) from an erythritol-producing yeast Yarrowia lipolytica using surface display technology was demonstrated. The engineered strain CGMCC11369 was developed by fusion of the β-galactosidase gene from Aspergillus oryzae to the YlPir1 gene, which codes for a cell wall protein. β-Galactosidase was effectively displayed on the cell surface of Yarrowia lipolytica start strain CGMCC7326. This engineered strain with surface-displayed β-galactosidase efficiently synthesized GOS from lactose. An amount of 160 g/L GOS was produced within 6 h in a solution of 500 g/L lactose and 5 mg/mL cell (dry weight) at pH 5.5 and 60 °C, with a yield of 51% of consumed lactose monohydrate. This newly developed method was applied with waste yeast paste from erythritol industry at least 10 times. The optimal reaction temperature increased to 60 °C, about 20 °C higher than that of free β-galactosidase, which was helpful for enhancing the reaction rate and GOS production. PMID:27090877

  14. Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs

    Directory of Open Access Journals (Sweden)

    Riquelme Paloma

    2012-09-01

    Full Text Available Abstract Several types of myeloid suppressor cell are currently being developed as cell-based immunosuppressive agents. Despite detailed knowledge about the molecular and cellular functions of these cell types, expert opinions differ on how to best implement such therapies in solid organ transplantation. Efforts in our laboratory to develop a cell-based medicinal product for promoting tolerance in renal transplant patients have focused on a type of suppressor macrophage, which we call the regulatory macrophage (M reg. Our favoured clinical strategy is to administer donor-derived M regs to recipients one week prior to transplantation. In contrast, many groups working with tolerogenic dendritic cells (DCs advocate post-transplant administration of recipient-derived cells. A third alternative, using myeloid-derived suppressor cells, presumably demands that cells are given around the time of transplantation, so that they can infiltrate the graft to create a suppressive environment. On present evidence, it is not possible to say which cell type and treatment strategy might be clinically superior. This review seeks to position our basic scientific and early-stage clinical studies of human regulatory macrophages within the broader context of myeloid suppressor cell therapy in transplantation.

  15. Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs.

    Science.gov (United States)

    Riquelme, Paloma; Geissler, Edward K; Hutchinson, James A

    2012-01-01

    Several types of myeloid suppressor cell are currently being developed as cell-based immunosuppressive agents. Despite detailed knowledge about the molecular and cellular functions of these cell types, expert opinions differ on how to best implement such therapies in solid organ transplantation. Efforts in our laboratory to develop a cell-based medicinal product for promoting tolerance in renal transplant patients have focused on a type of suppressor macrophage, which we call the regulatory macrophage (M reg). Our favoured clinical strategy is to administer donor-derived M regs to recipients one week prior to transplantation. In contrast, many groups working with tolerogenic dendritic cells (DCs) advocate post-transplant administration of recipient-derived cells. A third alternative, using myeloid-derived suppressor cells, presumably demands that cells are given around the time of transplantation, so that they can infiltrate the graft to create a suppressive environment. On present evidence, it is not possible to say which cell type and treatment strategy might be clinically superior. This review seeks to position our basic scientific and early-stage clinical studies of human regulatory macrophages within the broader context of myeloid suppressor cell therapy in transplantation. PMID:23369628

  16. An alternative approach to approximate entropy threshold value (r) selection: application to heart rate variability and systolic blood pressure variability under postural challenge.

    Science.gov (United States)

    Singh, A; Saini, B S; Singh, D

    2016-05-01

    This study presents an alternative approach to approximate entropy (ApEn) threshold value (r) selection. There are two limitations of traditional ApEn algorithm: (1) the occurrence of undefined conditional probability (CPu) where no template match is found and (2) use of a crisp tolerance (radius) threshold 'r'. To overcome these limitations, CPu is substituted with optimum bias setting ɛ opt which is found by varying ɛ from (1/N - m) to 1 in the increments of 0.05, where N is the length of the series and m is the embedding dimension. Furthermore, an alternative approach for selection of r based on binning the distance values obtained by template matching to calculate ApEnbin is presented. It is observed that ApEnmax, ApEnchon and ApEnbin converge for ɛ opt = 0.6 in 50 realizations (n = 50) of random number series of N = 300. Similar analysis suggests ɛ opt = 0.65 and ɛ opt = 0.45 for 50 realizations each of fractional Brownian motion and MIX(P) series (Lu et al. in J Clin Monit Comput 22(1):23-29, 2008). ɛ opt = 0.5 is suggested for heart rate variability (HRV) and systolic blood pressure variability (SBPV) signals obtained from 50 young healthy subjects under supine and upright position. It is observed that (1) ApEnbin of HRV is lower than SBPV, (2) ApEnbin of HRV increases from supine to upright due to vagal inhibition and (3) ApEnbin of BPV decreases from supine to upright due to sympathetic activation. Moreover, merit of ApEnbin is that it provides an alternative to the cumbersome ApEnmax procedure. PMID:26253284

  17. Government agencies and alternative environmental conflict management: the Michigan Oil and Gas Leasing Task Force as a dispute resolution process. (Volumes I and II)

    Energy Technology Data Exchange (ETDEWEB)

    Lesnick, M.T.

    1986-01-01

    Environmental decision making by government agencies is typically controversial and the focal point for many environmental disputes. New, alternative environmental conflict management processes that emphasize negotiation and problem-solving, hold the potential to more effectively manage these complex disputes. However, because these processes are relatively new, little is known about the actual advantages and disadvantages of participating. Using six conceptual dimensions and twelve hypotheses, this dissertation examined the impacts of participation on an agency's: organizational structures and processes; ability to formulate and implement policy; and decision making authority. Data were collected from participants and observers of the Oil and Gas Leasing Task Force conducted by the Michigan Department of Natural Resources (DNR). This was a two-year, policy-level process initiated by the agency to resolve internal and external disputes over the state's leasing policy. The seventeen member Task Force of DNR staff, environmentalists and oil and gas industry representatives; revised the state's oil and gas lease; developed and implemented administrative rules; and revised the DNR's environmental field review process. Data analysis showed that the Task Force resolved internal differences between DNR divisions over the goals of the oil and gas program.

  18. New volume and inverse volume operators for loop quantum gravity

    CERN Document Server

    Yang, Jinsong

    2016-01-01

    A new alternative volume operator is constructed for loop quantum gravity by using the so-called co-triad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The new inverse volume operator can be employed to construct the Hamiltonian operator of matter fields, which may lead to an anomaly-free on shell quantum constraint algebra without any special restriction on the regularization procedure for gravity coupled to matter fields.

  19. New volume and inverse volume operators for loop quantum gravity

    Science.gov (United States)

    Yang, Jinsong; Ma, Yongge

    2016-08-01

    A new alternative volume operator is constructed for loop quantum gravity by using the so-called cotriad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The new inverse volume operator can be employed to construct the Hamiltonian operator of matter fields, which may lead to an anomaly-free on-shell quantum constraint algebra without any special restriction on the regularization procedure for gravity coupled to matter fields.

  20. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis.

    Science.gov (United States)

    Pfuhler, Stefan; Kirst, Annette; Aardema, Marilyn; Banduhn, Norbert; Goebel, Carsten; Araki, Daisuke; Costabel-Farkas, Margit; Dufour, Eric; Fautz, Rolf; Harvey, James; Hewitt, Nicola J; Hibatallah, Jalila; Carmichael, Paul; Macfarlane, Martin; Reisinger, Kerstin; Rowland, Joanna; Schellauf, Florian; Schepky, Andreas; Scheel, Julia

    2010-01-01

    For the assessment of genotoxic effects of cosmetic ingredients, a number of well-established and regulatory accepted in vitro assays are in place. A caveat to the use of these assays is their relatively low specificity and high rate of false or misleading positive results. Due to the 7th amendment to the EU Cosmetics Directive ban on in vivo genotoxicity testing for cosmetics that was enacted March 2009, it is no longer possible to conduct follow-up in vivo genotoxicity tests for cosmetic ingredients positive in in vitro genotoxicity tests to further assess the relevance of the in vitro findings. COLIPA, the European Cosmetics Association, has initiated a research programme to improve existing and develop new in vitro methods. A COLIPA workshop was held in Brussels in April 2008 to analyse the best possible use of available methods and approaches to enable a sound assessment of the genotoxic hazard of cosmetic ingredients. Common approaches of cosmetic companies are described, with recommendations for evaluating in vitro genotoxins using non-animal approaches. A weight of evidence approach was employed to set up a decision-tree for the integration of alternative methods into tiered testing strategies. PMID:20382194

  1. Volume Overload Cleanup: An Approach for On-line SPE-GC, GPC-GC and GPC-SPE-GC

    NARCIS (Netherlands)

    Kerkdijk, H.; Mol, J.G.J.; Nagel, van der B.

    2007-01-01

    A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determi

  2. Alternative treatment approach to cerebral toxoplasmosis in HIV/AIDS: experience from a resource-poor setting.

    Science.gov (United States)

    Goswami, Rama Prosad; Goswami, Rudra Prosad; Rahman, Mehebubar; Ray, Yogiraj; Tripathi, Santanu Kumar

    2015-10-01

    The current standard treatment for cerebral toxoplasmosis (pyrimethamine/sulfadiazine) often encounters problems of poor tolerability, adverse effects, frequent dropouts and non-availability of pyrimethamine/sulfadiazine in some parts of India. We have had to use the combination of two effective alternative agents for toxoplasmosis, cotrimoxazole and clindamycin, on compassionate grounds. This retrospective observational study reports superior efficacy and better tolerability of cotrimoxazole/clindamycin compared to the recommended regimen. Primary end-point (complete response) was defined as more than 50% improvement of clinical status or more than 50% decrease in the size of brain lesions after two weeks of treatment initiation. Complete response occurred more commonly with cotrimoxazole/clindamycin than with pyrimethamine/sulfadiazine group (80% vs. 31.25%, respectively, relative risk 2.56, 95% confidence interval: 1.21-5.43). There was a trend towards higher on-treatment mortality in the pyrimethamine/sulfadiazine group in comparison to the cotrimoxazole/clindamycin (mortality rate 37.5% in pyrimethamine/sulfadiazine vs 12% in cotrimoxazole/clindamycin, p = 0.07, relative risk = 3.125, 95% confidence interval: 0.91-10.75). Overall, 62.5% (10/16) of patients on pyrimethamine/sulfadiazine suffered drug-related adverse reactions compared to 24% (6/25) on cotrimoxazole/clindamycin (p = 0.02, relative risk = 2.60, 95% confidence interval: 1.17-5.76). The commonest complication of pyrimethamine/sulfadiazine was severe thrombocytopenia with major bleeding (4/16, 25%). We propose that the new combination chemotherapy, which is widely available, effective and safe, can be used in developing countries. PMID:25411350

  3. Lean systems approaches to health technology assessment: a patient-focused alternative to cost-effectiveness analysis.

    Science.gov (United States)

    Bridges, John F P

    2006-12-01

    Many countries now use health technology assessment (HTA) to review new and emerging technologies, especially with regard to reimbursement, pricing and/or clinical guidelines. One of the common, but not universal, features of these systems is the use of economic evaluation, normally cost-effectiveness analysis (CEA), to confirm that new technologies offer value for money. Many have criticised these systems as primarily being concerned with cost containment, rather than advancing the interests of patients or innovators. This paper calls into question the underlying principles of CEA by arguing that value in the healthcare system may in fact be unconstrained. It is suggested that 'lean management principles' can be used not only to trim waste from the health system, but as a method of creating real incentives for innovation and value creation. Following the lean paradigm, this value must be defined purely from the patients' perspective, and the entire health system needs to work towards the creation of such value. This paper offers as a practical example a lean approach to HTA, arguing that such an approach would lead to better incentives for innovation in health, as well as more patient-friendly outcomes in the long run. PMID:23389493

  4. Cost benefit indicators associated with the integration of alternative energy sources: A systems approach for Carinthia, Austria

    DEFF Research Database (Denmark)

    Wohlgemuth, N.

    1999-01-01

    , over the horizon to 2020, the technical and market penetration potentials of AES in the context of the Carinthian energy system. Apart from market penetration rates, cost benefit indicators are also computed to support the decision making process in the local energy and environmental policy. These...... indicators comprise import dependency, employment effects, capital expenditure, carbon dioxide emissions and government revenues. The systems approach adopted, the simultaneous consideration of not only market penetration rates but also of the associated economic indicators, gives a more complete picture of...... AES use. Analysis of two strategies, "Subsidy" and "High Tax", shows that none of these strategies is dominant with respect to all indicators, i.e., there are conflicting objectives. (C) 1998 Elsevier Science Ltd. All rights reserved....

  5. An alternative approach for child labour in developing countries: Child labour participation rates or school non-attendance rates

    Directory of Open Access Journals (Sweden)

    Ozcan Dagdemir

    2010-06-01

    Full Text Available Child labour widely measured by child labour participation rates in literature is considered by non-attendance rates in primary education in this study. Along with this approach, it is attempted to investigate in what closeness the child labour ratios of countries are also measured by school non-attendance rates. The data is collected from UNICEF and World Bank. 85 developing countries take part in cross-country analysis by ordinary least square technique. The time period interval is 2000-2007 years and the average of those eight years is used. It has been found that non-attendance rates to primary education in developing countries can be a statistically possible proxy variable at the cases of unavailable child labour participation rates data.

  6. An alternative approach to indirect land use change: Allocating greenhouse gas effects among different uses of land

    International Nuclear Information System (INIS)

    Indirect land use change (iLUC) is hypothesized to occur when increasing demand for land due to bioenergy production displaces food and feed production onto new lands, thereby potentially producing large greenhouse gas emissions (GHG) during the land conversion event. Thus far, the totality of the projected iLUC effect has been assigned to biofuel production. In fact, multiple drivers of land use change exist and the resulting GHG releases should, in fairness, be allocated among these drivers. It seems more useful and intellectually rigorous to allocate potential land use change effects among these many drivers. This paper focuses on how to allocate the environmental consequences of iLUC to the multiple drivers through a function-oriented approach, namely human nutritional requirements for calories and protein. “Food versus Biofuel” issues can then be more usefully addressed as “Nutrition versus Biofuel” issues. Human beings actually have many choices in how we provide ourselves with adequate diets, and these choices have very different GHG and land use consequences. Therefore, in this paper, GHG assigned to iLUC is allocated between ethanol and human dietary preferences via a human nutrition-based method. Applying allocation approaches to iLUC lowers the estimated GHG of iLUC by up to 73% compared to GHG estimates in the GTAP model. For example, global warming intensity (GWI) of ethanol measured as CO2 equivalent becomes 58.2 g MJ−1, while GWI of ethanol calculated using GREET is 68.9 g MJ−1. -- Highlights: ► Biofuel production is one of many factors driving indirect land use change (iLUC). ► A proper allocation of the consequences of iLUC among these drivers is required. ► There are many choices in how we provide ourselves nutritionally adequate diets. ► Greenhouse gas emissions of iLUC are allocated via a human nutrition-based method.

  7. Evolution of porosity in the saltwater freshwater mixing zone of coastal carbonate aquifers: An alternative modelling approach

    Science.gov (United States)

    Romanov, Douchko; Dreybrodt, Wolfgang

    2006-10-01

    SummaryDissolution of calcium carbonate in the saltwater-freshwater mixing zone in carbonate islands and coastal aquifers up to now has been treated by coupling geochemical equilibrium programmes to a reactive-transport model. The result is a complex nonlinearly coupled set of differential transport-advection equations, which need high computational efforts. If dissolution rates of calcite are sufficiently fast, such that one can assume the solution to be in equilibrium with respect to calcite a highly simplified modelling approach can be used. By use of the concept of Phillips in his book: Flow and Reactions in Permeable Rock, Cambridge University Press, New York (1991) and its more general formulation by De Simoni et al. [De Simoni, M., Carrera, J., Sánchez-Vila, X., Guadagnini, A., 2005. A procedure for the solution of multicomponent reactive transport problems, Water Resource Research, 41, W11410.], it is possible to decouple the complex set of equations. To calculate initial changes of porosity in the rock matrix one needs solely to solve the advection-transport equation for salinity s. Current codes on density driven flow such as SEAWAT can be used. To obtain the dissolution capacity of the mixed saltwater-freshwater solution the calcium equilibrium concentration ceq( s) is obtained as a function of salinity by PHREEQC-2. Initial porosity changes can then be calculated by a simple analytical expression of the gradient of the spatial distribution s( x, y) of salinity, the distribution of flow fluxes q( x, y) and the second derivative of the calcium equilibrium concentration ceq( s) with respect to salinity s. This approach does no longer require large dispersivities on the order of meters; but reasonable results are obtained with dispersivity on the scale of the pore size of the porous rock, which correctly describes mixing on the molecular scale. The method is applied to a simple 1-D-domain without convective flow and a constant gradient of salinity as

  8. Model estimation of cerebral hemodynamics between blood flow and volume changes: a data-based modelling approach

    OpenAIRE

    Wei, H L; Zheng, Y; Pan, Y.; Coca, D.; Li, L M; Mayhew, J.E.W.; S. A. Billings

    2008-01-01

    It is well known that there is a dynamic relationship between cerebral blood flow (CBF) and cerebral blood volume (CBV). With increasing applications of functional magnetic resonance imaging (fMRI), where the blood oxygen level dependent (BOLD) signals are recorded, the understanding and accurate modelling of the hemodynamic relationship between CBF and CBV becomes increasingly important. This study presents an empirical and data-based modelling framework for model identification from CBF and...

  9. Target volume definition for external beam partial breast radiotherapy: Clinical, pathological and technical studies informing current approaches

    International Nuclear Information System (INIS)

    Partial breast irradiation (PBI) is currently under investigation in several phase III trials and, following a recent consensus statement, its use off-study may increase despite ongoing uncertainty regarding optimal target volume definition. We review the clinical, pathological and technical evidence for target volume definition in external beam partial breast irradiation (EB-PBI). The optimal method of tumour bed (TB) delineation requires X-ray CT imaging of implanted excision cavity wall markers. The definition of clinical target volume (CTV) as TB plus concentric 15 mm margins is based on the anatomical distribution of multifocal and multicentric disease around the primary tumour in mastectomy specimens, and the clinical locations of local tumour relapse (LR) after breast conservation surgery. If the majority of LR originate from foci of residual invasive and/or intraduct disease in the vicinity of the TB after complete microscopic resection, CTV margin logically takes account of the position of primary tumour within the surgical resection specimen. The uncertain significance of independent primary tumours as sources of preventable LR, and of wound healing responses in stimulating LR, increases the difficulties in defining optimal CTV. These uncertainties may resolve after long-term follow-up of current PBI trials. By contrast, a commonly used 10 mm clinical to planning target volume (PTV) margin has a stronger evidence base, although departmental set-up errors need to be confirmed locally. A CTV-PTV margin >10 mm may be required in women with larger breasts and/or large seromas, whilst the role of image-guided radiotherapy with or without TB markers in reducing CTV-PTV margins needs to be explored.

  10. An artificial intelligence approach for modeling volume and fresh weight of callus - A case study of cumin (Cuminum cyminum L.).

    Science.gov (United States)

    Mansouri, Ali; Fadavi, Ali; Mortazavian, Seyed Mohammad Mahdi

    2016-05-21

    Cumin (Cuminum cyminum Linn.) is valued for its aroma and its medicinal and therapeutic properties. A supervised feedforward artificial neural network (ANN) trained with back propagation algorithms, was applied to predict fresh weight and volume of Cuminum cyminum L. calli. Pearson correlation coefficient was used to evaluate input/output dependency of the eleven input parameters. Area, feret diameter, minor axis length, perimeter and weighted density parameters were chosen as input variables. Different training algorithms, transfer functions, number of hidden nodes and training iteration were studied to find out the optimum ANN structure. The network with conjugate gradient fletcher-reeves (CGF) algorithm, tangent sigmoid transfer function, 17 hidden nodes and 2000 training epochs was selected as the final ANN model. The final model was able to predict the fresh weight and volume of calli more precisely relative to multiple linear models. The results were confirmed by R(2)≥0.89, R(i)≥0.94 and T value ≥0.86. The results for both volume and fresh weight values showed that almost 90% of data had an acceptable absolute error of ±5%. PMID:26987421

  11. Alternating current multi-circuit electric machines a new approach to the steady-state parameter determination

    CERN Document Server

    Asanbayev, Valentin

    2015-01-01

    This book details an approach for realization of the field decomposition concept. The book presents the  methods as well as techniques and procedures for establishing electric machine circuit-loops and determining their parameters. The methods developed have been realized using the models of machines with laminated and solid rotor having classical structure. The use of such models are well recognized and simplifies practical implementation of the obtained results. This book also: ·         Includes methods for a construction of electric machine equivalent circuits that allows the replacement of the field models of the machine with simple circuit models ·         Demonstrates the practical implementation of the proposed techniques and procedures ·         Presents parameters of the circuit-loops in the form most convenient for practical implementation ·         Uses methods based on machine models widely used in practice

  12. A novel approach to PTSD modeling in rats reveals alternating patterns of limbic activity in different types of stress reaction.

    Science.gov (United States)

    Ritov, G; Boltyansky, B; Richter-Levin, G

    2016-05-01

    Human reactions to trauma exposure are extremely diverse, with some individuals exhibiting only time-limited distress and others qualifying for posttraumatic stress disorder diagnosis (PTSD). Furthermore, whereas most PTSD patients mainly display fear-based symptoms, a minority of patients display a co-morbid anhedonic phenotype. We employed an individual profiling approach to model these intriguing facets of the psychiatric condition in underwater-trauma exposed rats. Based on long-term assessments of anxiety-like and anhedonic behaviors, our analysis uncovered three separate phenotypes of stress response; an anxious, fear-based (38%), a co-morbid, fear-anhedonic (15%), and an exposed-unaffected group (47%). Immunohistochemical assessments for cellular activation (c-Fos) and activation of inhibition (c-Fos+GAD67) revealed a differential involvement of limbic regions and distinct co-activity patterns for each of these phenotypes, validating the behavioral categorization. In accordance with recent neurocognitive hypotheses for posttraumatic depression, we show that enhanced pretrauma anxiety predicts the progression of posttraumatic anhedonia only in the fear-anhedonic phenotype. PMID:26552592

  13. Single-stage repair of adult aortic coarctation and concomitant cardiovascular pathologies: a new alternative surgical approach

    Directory of Open Access Journals (Sweden)

    Saba Davit

    2006-06-01

    Full Text Available Abstract Background Coarctation of the aorta in the adulthood is sometimes associated with additional cardiovascular pathologies that require intervention. Ideal approach in such patients is uncertain. Anatomic left-sided short aortic bypass from the arcus aorta to descending aorta via median sternotomy allows simultaneuos repair of both complex aortic coarctation and concomitant cardiac operation. Materials Four adult patients were underwent Anatomic left-sided short aortic bypass operation for complex aortic coarctation through median sternotomy using deep hypothermic circulatory arrest. Concomitant cardiac operations were Bentall procedure for annuloaortic ectasia in one patient, coronary artery bypass grafting for three vessel disease in two patient, and patch closure of ventricular septal defect in one patient. Results All patients survived the operation and were alive with patent bypass at a mean follow-up of 36 months. No graft-related complications occurred, and there were no instances of stroke or paraplegia. Conclusion We conclude that single-stage repair of adult aortic coarctation with concomitant cardiovascular lesions can be performed safely using this newest technique.

  14. From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases

    Institute of Scientific and Technical Information of China (English)

    Antonin; Bukovsky

    2015-01-01

    Endogenous "stem cell niche"(SCN) accompanying vessels contains immune system components which in vivo determine differentiation of multi potent stem cells toward proper cell types in given tissue. Combinations of sex steroids may represent novel chemical approach for neuronal areas of regenerative medicine,since they cause transformation of vascular smooth muscle stem cells into differentiating neuronal cells. Circulating sex steroids are present during pregnancy and can be utilized where needed,when various embryonic/fetal tissues develop from their stem cells. Utilization of induced regeneration of tissues(regenerative medicine) is expected being more effective in sudden failures of younger individuals carrying intact SCN,as compared to established chronic disorders caused by SCN alteration. An essential component of SCN are monocyte-derived cells exhibiting tissue-specific "stop effect"(SE) preventing,for instance,an aging of neuronal cells. Its alteration causes that implantation of neuronal stem cells will also result in their differentiation toward aging cells. When we repair the SE by supply of circulating mononuclear cells from young healthy individuals,we may be able to provide novel regenerative treatments of age-induced neural diseases by sex steroid combinations. Questions regarding some age-induced body alterations are also addressed.

  15. Guidelines for selecting codes for ground-water transport modeling of low-level waste burial sites. Volume 1. Guideline approach

    International Nuclear Information System (INIS)

    This document was written for the National Low-Level Waste Management Program to provide guidance for managers and site operators who need to select ground-water transport codes for assessing shallow-land burial site performance. The guidance given in this report also serves the needs of applications-oriented users who work under the direction of a manager or site operator. The guidelines are published in two volumes designed to support the needs of users having different technical backgrounds. An executive summary, published separately, gives managers and site operators an overview of the main guideline report. This volume includes specific recommendations for decision-making managers and site operators on how to use these guidelines. The more detailed discussions about the code selection approach are provided. 242 refs., 6 figs

  16. A digital approach to fabricating an abutment replica to control cement volume in a cement-retained implant prosthesis.

    Science.gov (United States)

    Lee, Ju-Hyoung; Park, In-Sook; Sohn, Dong-Seok

    2016-07-01

    If a cement-retained implant prosthesis is placed on an abutment, excess cement should be minimized or removed to prevent periimplant inflammation. Various methods for fabricating an abutment replica have been introduced to maintain tissue health and reduce clean-up time. The purpose of this article is to present an alternative technique for fabricating an abutment replica with computer-aided design/computer-aided manufacturing (CAD/CAM) technology. PMID:26946917

  17. Social impact evaluation : Some implications of the specific decisional context approach for anticipatory project assessment with special reference to available alternatives and to techniques of evaluating the social impacts of the anticipated effects of such alternatives

    Science.gov (United States)

    Mayo, L. H.

    1972-01-01

    The implications are explored of the specific decision context approach to anticipatory project assessment. More specifically, it is hypothesized that with respect to any given effect of a proposed project or action (mobility, job opportunities, air pollution, population distribution, etc.) such effect will likely differ in probability and/or magnitude from one decisional context to another; that the social desirability or undesirability of a given effect is a function (will differ with) each specific decisional context; that therefore the social impact of such effect will in all likelihood differ with each specific decisional context; and that the social significance of even the dame social impact of a given effect will vary from one decisional context to another when such social impact interacts with (competes with or reinforces) the social impacts of other effects. It also follows from this analysis that the respective roles of scientific method (demonstrable data) and adversarial system will not only differ with each specific decisional context but with each alternative course of action available to the decisional entity in each specific context.

  18. Reduce in Variation and Improve Efficiency of Target Volume Delineation by a Computer-Assisted System Using a Deformable Image Registration Approach

    International Nuclear Information System (INIS)

    Purpose: To determine whether a computer-assisted target volume delineation (CAT) system using a deformable image registration approach can reduce the variation of target delineation among physicians with different head and neck (HN) IMRT experiences and reduce the time spent on the contouring process. Materials and Methods: We developed a deformable image registration method for mapping contours from a template case to a patient case with a similar tumor manifestation but different body configuration. Eight radiation oncologists with varying levels of clinical experience in HN IMRT performed target delineation on two HN cases, one with base-of-tongue (BOT) cancer and another with nasopharyngeal cancer (NPC), by first contouring from scratch and then by modifying the contours deformed by the CAT system. The gross target volumes were provided. Regions of interest for comparison included the clinical target volumes (CTVs) and normal organs. The volumetric and geometric variation of these regions of interest and the time spent on contouring were analyzed. Results: We found that the variation in delineating CTVs from scratch among the physicians was significant, and that using the CAT system reduced volumetric variation and improved geometric consistency in both BOT and NPC cases. The average timesaving when using the CAT system was 26% to 29% for more experienced physicians and 38% to 47% for the less experienced ones. Conclusions: A computer-assisted target volume delineation approach, using a deformable image-registration method with template contours, was able to reduce the variation among physicians with different experiences in HN IMRT while saving contouring time

  19. Observational Study Designs for Comparative Effectiveness Research: An Alternative Approach to Close Evidence Gaps in Head-and-Neck Cancer

    International Nuclear Information System (INIS)

    Comparative effectiveness research (CER) has emerged as an approach to improve quality of care and patient outcomes while reducing healthcare costs by providing evidence to guide healthcare decisions. Randomized controlled trials (RCTs) have represented the ideal study design to support treatment decisions in head-and-neck (H and N) cancers. In RCTs, formal chance (randomization) determines treatment allocation, which prevents selection bias from distorting the measure of treatment effects. Despite this advantage, only a minority of patients qualify for inclusion in H and N RCTs, which limits the validity of their results to the broader H and N cancer patient population seen in clinical practice. Randomized controlled trials often do not address other knowledge gaps in the management of H and N cancer, including treatment comparisons for rare types of H and N cancers, monitoring of rare or late toxicity events (eg, osteoradionecrosis), or in some instances an RCT is simply not feasible. Observational studies, or studies in which treatment allocation occurs independently of investigators' choice or randomization, may address several of these gaps in knowledge, thereby complementing the role of RCTs. This critical review discusses how observational CER studies complement RCTs in generating the evidence to inform healthcare decisions and improve the quality of care and outcomes of H and N cancer patients. Review topics include a balanced discussion about the strengths and limitations of both RCT and observational CER study designs; a brief description of design and analytic techniques to handle selection bias in observational studies; examples of observational studies that inform current clinical practices and management of H and N cancers; and suggestions for relevant CER questions that could be addressed by an observational study design

  20. A STATISTICAL CONCEPT IN DETERMINATION OF THRESHOLD VALUE FOR FUTURE DIAGNOSIS IN MTS: AN ALTERNATIVE TO TAGUCHI?S LOSS FUNCTION APPROACH

    Directory of Open Access Journals (Sweden)

    Prasun Das

    2010-06-01

    Full Text Available Mahalanobis-Taguchi System (MTS is a pattern information technology, which has been used in different diagnostic applications to make quantitative decisions by constructing a multivariate measurement scale using data analytic methods, without any assumption regarding statistical distribution. It uses a threshold value computed through quadratic loss function approach for the future diagnosis. However, the procedure for determining the threshold is lacking statistical explanation and primarily dependent on the domain expertise, if available, from the respective field. This study makes an alternate attempt to determine a threshold value using the property of multivariate statistical distributions related to Mahalanobis D2, used for MTS, and the critical values of the distributions for different levels of significance. The findings of the study can be used to eliminate the subjectivity of MTS in compliance to its data analytic philosophy.