WorldWideScience

Sample records for alternative approaches volume

  1. A new approach for volume reconstruction in TomoPIV with the alternating direction method of multipliers

    Science.gov (United States)

    Barbu, Ioana; Herzet, Cédric

    2016-10-01

    We adapt and import into the TomoPIV scenery a fast algorithm for solving the volume reconstruction problem. Our approach is based on the reformulation of the volume reconstruction task as a constrained optimization problem and the resort to the ‘alternating directions method of multipliers’ (ADMM). The inherent primal-dual algorithm is summarized in this article to solve the optimization problem related to the TomoPIV. In particular, the general formulation of the volume reconstruction problem considered in this paper allows one to: (i) take explicitly into account the level of the noise affecting the data; (ii) account for both the nonnegativity and the sparsity of the solution. Experiments on a numerical TomoPIV benchmark show that the proposed framework is a serious contender for the state-of-the-art.

  2. Human factors evaluation of teletherapy: Identification of problems and alternative approaches. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Henriksen, K.; Kaye, R.D.; Jones, R. [Hughes Training, Inc., Falls Church, VA (United States); Morisseau, D.S.; Serig, D.I. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Systems Technology

    1995-07-01

    A series of human factors evaluations was undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multi-disciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. The principal sources of radiation are a radioactive isotope, typically cobalt60 (Co-60), or a linear accelerator device capable of producing very high energy x-ray and electron beams. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of user-system interfaces, procedures, training and qualifications, and organizational policies and practices. The final phase of the project focused on identification of the most significant human factors problems with respect to safe and effective operation of the teletherapy system and an identification and assessment of alternative approaches for resolving the problems. This report presents the findings of this final phase.

  3. Human factors evaluation of teletherapy: Identification of problems and alternative approaches. Volume 1

    International Nuclear Information System (INIS)

    A series of human factors evaluations was undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multi-disciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. The principal sources of radiation are a radioactive isotope, typically cobalt60 (Co-60), or a linear accelerator device capable of producing very high energy x-ray and electron beams. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of user-system interfaces, procedures, training and qualifications, and organizational policies and practices. The final phase of the project focused on identification of the most significant human factors problems with respect to safe and effective operation of the teletherapy system and an identification and assessment of alternative approaches for resolving the problems. This report presents the findings of this final phase

  4. Alternative approaches in IVF

    OpenAIRE

    Fauser, Bart; Bouchard, P.; Coelingh Bennink, H.J.; Collins, John; Devroey, P.; Evers, Johannes; Van Steirteghem, A

    2002-01-01

    textabstractVarious new developments in clinical and basic science which may impact on IVF in the near or distant future will be discussed in this review. These key areas include the regulation of early follicle development and the extended in-vitro culture of oocytes and embryos. Moreover, alternative compounds and ovarian stimulation protocols will be discussed, along with highlights in the development of the cryopreservation of excess oocytes or embryos. Finally, the health economics of IV...

  5. FMDP reactor alternative summary report: Volume 4, Evolutionary LWR alternative

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] have become surplus to national defense needs both in the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES&H) consequences if surplus fissile materials are not properly managed. The purpose of this report is to provide schedule, cost, and technical information that will be used to support the Record of Process (ROD). Following the screening process, DOE/MD via its national laboratories initiated a more detailed analysis activity to further evaluate each of the ten plutonium disposition alternatives that survived the screening process. Three ``Alternative Teams,`` chartered by DOE and comprised of technical experts from across the DOE national laboratory complex, conducted these analyses. One team was chartered for each of the major disposition classes (borehole, immobilization, and reactors). During the last year and a half, the Fissile Materials Disposition Program (FMDP) Reactor Alternative Team (RxAT) has conducted extensive analyses of the cost, schedule, technical maturity, S&S, and other characteristics of reactor-based plutonium disposition. The results of the RxAT`s analyses of the existing LWR, CANDU, and partially complete LWR alternatives are documented in Volumes 1-3 of this report. This document (Volume 4) summarizes the results of these analyses for the ELWR-based plutonium disposition option.

  6. FMDP reactor alternative summary report: Volume 4, Evolutionary LWR alternative

    International Nuclear Information System (INIS)

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] have become surplus to national defense needs both in the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. The purpose of this report is to provide schedule, cost, and technical information that will be used to support the Record of Process (ROD). Following the screening process, DOE/MD via its national laboratories initiated a more detailed analysis activity to further evaluate each of the ten plutonium disposition alternatives that survived the screening process. Three ''Alternative Teams,'' chartered by DOE and comprised of technical experts from across the DOE national laboratory complex, conducted these analyses. One team was chartered for each of the major disposition classes (borehole, immobilization, and reactors). During the last year and a half, the Fissile Materials Disposition Program (FMDP) Reactor Alternative Team (RxAT) has conducted extensive analyses of the cost, schedule, technical maturity, S ampersand S, and other characteristics of reactor-based plutonium disposition. The results of the RxAT's analyses of the existing LWR, CANDU, and partially complete LWR alternatives are documented in Volumes 1-3 of this report. This document (Volume 4) summarizes the results of these analyses for the ELWR-based plutonium disposition option

  7. Potential alternative approaches to xenotransplantation.

    Science.gov (United States)

    Mou, Lisha; Chen, Fengjiao; Dai, Yifan; Cai, Zhiming; Cooper, David K C

    2015-11-01

    There is an increasing worldwide shortage of organs and cells for transplantation in patients with end-stage organ failure or cellular dysfunction. This shortage could be resolved by the transplantation of organs or cells from pigs into humans. What competing approaches might provide support for the patient with end-stage organ or cell failure? Four main approaches are receiving increasing attention - (i) implantable mechanical devices, although these are currently limited almost entirely to devices aimed at supporting or replacing the heart, (ii) stem cell technology, at present directed mainly to replace absent or failing cells, but which is also fundamental to progress in (iii) tissue engineering and regenerative medicine, in which the ultimate aim is to replace an entire organ. A final novel potential approach is (iv) blastocyst complementation. These potential alternative approaches are briefly reviewed, and comments added on their current status and whether they are now (or will soon become) realistic alternative therapies to xenotransplantation.

  8. 18 CFR 281.304 - Computation of alternative fuel volume.

    Science.gov (United States)

    2010-04-01

    ... alternative fuel volume. 281.304 Section 281.304 Conservation of Power and Water Resources FEDERAL ENERGY... Determination § 281.304 Computation of alternative fuel volume. (a) General rule. For purposes of § 281.208(b)(1)(i)(B), and § 281.305: (1) Alternative fuel volume of an essential agricultural user is equal to...

  9. Ironmaking Process Alternative Screening Study, Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Lockwood Greene, . .

    2005-01-06

    Iron in the United States is largely produced from iron ore mined in the United States or imported from Canada or South America. The iron ore is typically smelted in Blast Furnaces that use primarily iron ore, iron concentrate pellets metallurgical coke, limestone and lime as the raw materials. Under current operating scenarios, the iron produced from these Blast Furnaces is relatively inexpensive as compared to current alternative iron sources, e.g. direct iron reduction, imported pig iron, etc. The primary problem the Blast Furnace Ironmaking approach is that many of these Blast furnaces are relatively small, as compared to the newer, larger Blast Furnaces; thus are relatively costly and inefficient to operate. An additional problem is also that supplies of high-grade metallurgical grade coke are becoming increasingly in short supply and costs are also increasing. In part this is due to the short supply and costs of high-grade metallurgical coals, but also this is due to the increasing necessity for environmental controls for coke production. After year 2003 new regulations for coke product environmental requirement will likely be promulgated. It is likely that this also will either increase the cost of high-quality coke production or will reduce the available domestic U.S. supply. Therefore, iron production in the United States utilizing the current, predominant Blast Furnace process will be more costly and would likely be curtailed due to a coke shortage. Therefore, there is a significant need to develop or extend the economic viability of Alternate Ironmaking Processes to at least partially replace current and declining blast furnace iron sources and to provide incentives for new capacity expansion. The primary conclusions of this comparative Study of Alternative Ironmaking Process scenarios are: (1) The processes with the best combined economics (CAPEX and OPEX impacts in the I.R.R. calculation) can be grouped into those Fine Ore based processes with no scrap

  10. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    International Nuclear Information System (INIS)

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives

  11. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    Energy Technology Data Exchange (ETDEWEB)

    Greene, S.R.; Bevard, B.B. [and others

    1996-10-07

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES&H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives.

  12. FMDP Reactor Alternative Summary Report: Volume 2 - CANDU heavy water reactor alternative

    International Nuclear Information System (INIS)

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 2 of a four volume report, summarizes the results of these analyses for the CANDU reactor based plutonium disposition alternative

  13. FMDP Reactor Alternative Summary Report: Volume 3 - partially complete LWR alternative

    International Nuclear Information System (INIS)

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 3 of a four volume report summarizes the results of these analyses for the partially complete LWR (PCLWR) reactor based plutonium disposition alternative

  14. FMDP Reactor Alternative Summary Report: Volume 2 - CANDU heavy water reactor alternative

    Energy Technology Data Exchange (ETDEWEB)

    Greene, S.R.; Spellman, D.J.; Bevard, B.B. [and others

    1996-09-01

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 2 of a four volume report, summarizes the results of these analyses for the CANDU reactor based plutonium disposition alternative.

  15. Alternative approaches to plasma confinement

    Science.gov (United States)

    Roth, J. R.

    1978-01-01

    The paper discusses 20 plasma confinement schemes each representing an alternative to the tokamak fusion reactor. Attention is given to: (1) tokamak-like devices (TORMAC, Topolotron, and the Extrap concept), (2) stellarator-like devices (Torsatron and twisted-coil stellarators), (3) mirror machines (Astron and reversed-field devices, the 2XII B experiment, laser-heated solenoids, the LITE experiment, the Kaktus-Surmac concept), (4) bumpy tori (hot electron bumpy torus, toroidal minimum-B configurations), (5) electrostatically assisted confinement (electrostatically stuffed cusps and mirrors, electrostatically assisted toroidal confinement), (6) the Migma concept, and (7) wall-confined plasmas. The plasma parameters of the devices are presented and the advantages and disadvantages of each are listed.

  16. Alternative perturbation approaches in classical mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Amore, Paolo [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Colima, Colima (Mexico); Raya, Alfredo [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Colima, Colima (Mexico); Fernandez, Francisco M [INIFTA (Conicet, UNLP), Blvd. 113 y 64 S/N, Sucursal 4, Casilla de Correo 16, 1900 La Plata (Argentina)

    2005-11-01

    We discuss two alternative methods, based on the Lindstedt-Poincare technique, for the removal of secular terms from the equations of perturbation theory. We calculate the period of an anharmonic oscillator by means of both approaches and show that one of them is more accurate for all values of the coupling constant. We believe that present discussion and comparison may be a suitable exercise for teaching perturbation theory in advanced undergraduate courses on classical mechanics.

  17. Introducing linear functions: an alternative statistical approach

    Science.gov (United States)

    Nolan, Caroline; Herbert, Sandra

    2015-12-01

    The introduction of linear functions is the turning point where many students decide if mathematics is useful or not. This means the role of parameters and variables in linear functions could be considered to be `threshold concepts'. There is recognition that linear functions can be taught in context through the exploration of linear modelling examples, but this has its limitations. Currently, statistical data is easily attainable, and graphics or computer algebra system (CAS) calculators are common in many classrooms. The use of this technology provides ease of access to different representations of linear functions as well as the ability to fit a least-squares line for real-life data. This means these calculators could support a possible alternative approach to the introduction of linear functions. This study compares the results of an end-of-topic test for two classes of Australian middle secondary students at a regional school to determine if such an alternative approach is feasible. In this study, test questions were grouped by concept and subjected to concept by concept analysis of the means of test results of the two classes. This analysis revealed that the students following the alternative approach demonstrated greater competence with non-standard questions.

  18. Alternative algebraic approaches in quantum chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Mezey, Paul G., E-mail: paul.mezey@gmail.com [Canada Research Chair in Scientific Modeling and Simulation, Department of Chemistry and Department of Physics and Physical Oceanography, Memorial University of Newfoundland, 283 Prince Philip Drive, St. John' s, NL A1B 3X7 (Canada)

    2015-01-22

    Various algebraic approaches of quantum chemistry all follow a common principle: the fundamental properties and interrelations providing the most essential features of a quantum chemical representation of a molecule or a chemical process, such as a reaction, can always be described by algebraic methods. Whereas such algebraic methods often provide precise, even numerical answers, nevertheless their main role is to give a framework that can be elaborated and converted into computational methods by involving alternative mathematical techniques, subject to the constraints and directions provided by algebra. In general, algebra describes sets of interrelations, often phrased in terms of algebraic operations, without much concern with the actual entities exhibiting these interrelations. However, in many instances, the very realizations of two, seemingly unrelated algebraic structures by actual quantum chemical entities or properties play additional roles, and unexpected connections between different algebraic structures are often giving new insight. Here we shall be concerned with two alternative algebraic structures: the fundamental group of reaction mechanisms, based on the energy-dependent topology of potential energy surfaces, and the interrelations among point symmetry groups for various distorted nuclear arrangements of molecules. These two, distinct algebraic structures provide interesting interrelations, which can be exploited in actual studies of molecular conformational and reaction processes. Two relevant theorems will be discussed.

  19. An alternative approach to symmetric systems

    Science.gov (United States)

    Véron, Alain

    2016-11-01

    We propose an alternative approach to treat problems with axial or spherical symmetry. Its main characteristic consists of using Cartesian coordinates instead of curvilinear coordinates as usual. To this end, we derive general mathematical expressions giving the spatial derivatives of tensors of arbitrary order along the direction normal to an arbitrary meridian plane for systems with axial symmetry, or along two orthogonal directions normal to an arbitrary radius for systems with spherical symmetry. These relations allow the reduction of the initial three-dimensional problem to a domain with a lower dimension (two for axial symmetry, one for spherical symmetry), while keeping Cartesian coordinates within this domain. The method is illustrated for the flow of a Newtonian fluid between two coaxial cylinders (Couette cell), the Weissenberg effect for viscoelastic fluids and the flow of complex fluids like liquid crystals.

  20. Alternatives to traditional transportation fuels 1994. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    In this report, alternative and replacement fuels are defined in accordance with the EPACT. Section 301 of the EPACT defines alternative fuels as: methanol, denatured ethanol, and other alcohols; mixtures containing 85% or more (or such other percentage, but not less than 70%, as determined by the Secretary of Energy, by rule, to provide for requirements relating to cold start, safety, or vehicle functions) by volume of methanol, denatured ethanol, and other alcohols with gasoline or other fuels; natural gas; liquefied petroleum gas; hydrogen; coal-derived liquid fuels; fuels (other than alcohol) derived from biological materials; electricity (including electricity from solar energy); and any other fuel the Secretary determines, by rule, is substantially not petroleum and would yield substantial energy security benefits and substantial environmental benefits. The EPACT defines replacement fuels as the portion of any motor fuel that is methanol, ethanol, or other alcohols, natural gas, liquefied petroleum gas, hydrogen, coal-derived liquid fuels, fuels (other than alcohol) derived from biological materials, electricity (including electricity from solar energy), ethers, or any other fuel the Secretary of Energy determines, by rule, is substantially not petroleum and would yield substantial energy security benefits and substantial environmental benefits. This report covers only those alternative and replacement fuels cited in the EPACT that are currently commercially available or produced in significant quantities for vehicle demonstration purposes. Information about other fuels, such as hydrogen and biodiesel, will be included in later reports as those fuels become more widely used. Annual data are presented for 1992 to 1996. Data for 1996 are based on plans or projections for 1996.

  1. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 4. Alternatives for waste isolation and disposal

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume IV of the five-volume report contains information on alternatives for final storage and disposal of radioactive wastes. Section titles include: basic concepts for geologic isolation; geologic storage alternatives; geologic disposal alternatives; extraterrestrial disposal; and, transmutation. (JGB)

  2. Alternative Approaches to Recycling Nuclear Wastes

    Science.gov (United States)

    Hannum, William H.

    2007-04-01

    Nuclear power exists, and as the demand for non-fossil electricity generation increases, many more nuclear plants are being planned and built. The result is growing inventories of spent nuclear fuel containing plutonium that -- in principle, at least -- can be used to make nuclear explosives. There are countries and organizations that are believed to want nuclear weapons, posing a knotty proliferation problem that calls for realistic control of nuclear materials. Phasing out nuclear power and sequestering all dangerous materials in guarded storage or in geological formations would not be a realistic approach. Plutonium from commercial spent fuel is very hard to make into a weapon. However, a rogue nation could operate a power plant so as to produce plutonium with weapons-quality isotopics, and then chemically purify it. IAEA safeguards are designed to discourage this, but the only enforcement is referral to the United Nations General Assembly. The traditional reprocessing method, PUREX, produces plutonium that has the chemical purity needed for weapons. However, there are alternative approaches that produce only highly radioactive blends of fissionable materials and fission products. Recycle offers a market for spent nuclear fuel, promoting more rigorous accounting of these materials. Unlike PUREX, the new technologies permit the recycle and consumption of essentially all of the high-hazard transuranics, and will reduce the required isolation time for the waste to less than 500 years. Facilities for recovering recyclable materials from LWR spent fuel will be large and expensive. Only a very few such plants will be needed, leading to appropriate concentration of safeguards measures. Plants for recycling the spent fuel from fast burner reactors can be collocated with the power plants and share the safeguards.

  3. Alternative approach to fit irregular corneas

    OpenAIRE

    Espinosa Tomás, Julián; Pérez Rodríguez, Jorge; Mas Candela, David; Vázquez Ferri, Carmen; Illueca Contri, Carlos

    2010-01-01

    Comunicación presentada en 5th European Meeting on Visual and Physiological Optics (EMVPO), Stockholm, 22-24 August 2010. We propose a zonal Zernike fitting (combination of zonal and modal approaches) of corneal height data. It permits accurate analysis of the surface, diminishing the influence of smooth areas over irregular zones and vice versa. This fact will be of special interest in irregular corneas wavefront evaluation. This work has been supported by the Generalitat Valenciana pr...

  4. Alternative approaches to evaluation in empirical microeconomics

    OpenAIRE

    Blundell, Richard; Costa Dias, Monica

    2002-01-01

    This paper reviews a range of the most popular policy evaluation methods in empirical microeconomics: social experiments, natural experiments, matching methods, instrumental variables, discontinuity design and control functions. It discusses the identification of both the traditionally used average parameters and more complex distributional parameters. In each case, the necessary assumptions and the data requirements are considered. The adequacy of each approach is discussed drawing on the em...

  5. Matching Alternative Addresses: a Semantic Web Approach

    Science.gov (United States)

    Ariannamazi, S.; Karimipour, F.; Hakimpour, F.

    2015-12-01

    Rapid development of crowd-sourcing or volunteered geographic information (VGI) provides opportunities for authoritatives that deal with geospatial information. Heterogeneity of multiple data sources and inconsistency of data types is a key characteristics of VGI datasets. The expansion of cities resulted in the growing number of POIs in the OpenStreetMap, a well-known VGI source, which causes the datasets to outdate in short periods of time. These changes made to spatial and aspatial attributes of features such as names and addresses might cause confusion or ambiguity in the processes that require feature's literal information like addressing and geocoding. VGI sources neither will conform specific vocabularies nor will remain in a specific schema for a long period of time. As a result, the integration of VGI sources is crucial and inevitable in order to avoid duplication and the waste of resources. Information integration can be used to match features and qualify different annotation alternatives for disambiguation. This study enhances the search capabilities of geospatial tools with applications able to understand user terminology to pursuit an efficient way for finding desired results. Semantic web is a capable tool for developing technologies that deal with lexical and numerical calculations and estimations. There are a vast amount of literal-spatial data representing the capability of linguistic information in knowledge modeling, but these resources need to be harmonized based on Semantic Web standards. The process of making addresses homogenous generates a helpful tool based on spatial data integration and lexical annotation matching and disambiguating.

  6. Alternative Approaches to Group IV Thermoelectric Materials

    Science.gov (United States)

    Snedaker, Matthew Loren

    In the pursuit of energy efficiency, there is a demand for systems capable of recovering waste heat. A temperature gradient across a thermoelectric material results in the thermal diffusion of charge carriers from the hot side to the cold side, giving rise to a voltage that can be used to convert waste heat to electricity. Silicon germanium (SiGe) alloys are the standard materials used for thermoelectric generators at high temperatures. We report an alternative method for preparing p-type Si1- xGex alloys from a boron-doped silica-germania nanocomposite. This is the first demonstration of the thermoelectric properties of SiGe-based thermoelectrics prepared at temperatures below the alloy's melting point through a magnesiothermic reduction of the (SiO 2)1-x(GeO2) x. We observe a thermoelectric power factor that is competitive with the literature record for the conventionally prepared SiGe. The large grain size in our hot pressed SiGe limits the thermoelectric figure of merit to 0.5 at 800°C for an optimally doped p-type Si80Ge 20 alloy. A phosphorus-doped oxide can yield n-type Si1- xGex; however, the current processing method introduces a background boron content that compensates ~10% of the donor impurities and limits the thermoelectric power factor. Spark plasma sintering of the nano-Si1-xGe x yields a heterogeneous alloy with thermal conductivity lower than that of the hot pressed homogeneous alloy due to a reduction in the average crystallite size. Magnesiothermic reduction in the presence of molten salts allows some control over crystallite growth and the extent of Si-Ge alloying.

  7. Missile non-proliferation: an alternative approach

    International Nuclear Information System (INIS)

    In this report, the author first proposes an overview of the notion of missile prohibition. He notices that the association between weapons of mass destruction and missiles is a prelude to the legitimacy of missile control, notably within the framework of the Missile Technology Control Regime or MTCR. He also comments the notion of total ban. In a second part, the author analyses and discusses the limitations of the control of technology diffusion. He discusses the role of the MTCR, comments the evolution of this regime with the taking of China and Russia into consideration, the impacts of national implementations of export regimes on the MTCR, and economic aspects of control implementation. In the next part, the author addresses other kinds of limitations, i.e. those related with capacity evolutions of proliferating States. The last part addresses the evolution towards a new definition of approach to missile non-proliferation, notably in terms of perception of missile roles and of technology transfer controls

  8. Alternative Approaches to High Energy Density Fusion

    Science.gov (United States)

    Hammer, J.

    2016-10-01

    This paper explores selected approaches to High Energy Density (HED) fusion, beginning with discussion of ignition requirements at the National Ignition Facility (NIF). The needed improvements to achieve ignition are closely tied to the ability to concentrate energy in the implosion, manifested in the stagnation pressure, Pstag. The energy that must be assembled in the imploded state to ignite varies roughly as Pstag-2, so among other requirements, there is a premium on reaching higher Pstag to achieve ignition with the available laser energy. The U.S. inertial confinement fusion program (ICF) is pursuing higher Pstag on NIF through improvements to capsule stability and symmetry. One can argue that recent experiments place an approximate upper bound on the ultimate ignition energy requirement. Scaling the implosions consistently in spatial, temporal and energy scales shows that implosions of the demonstrated quality ignite robustly at 9-15 times the current energy of NIF. While lasers are unlikely to reach that bounding energy, it appears that pulsed-power sources could plausibly do so, giving a range of paths forward for ICF depending on success in improving energy concentration. In this paper, I show the scaling arguments then discuss topics from my own involvement in HED fusion. The recent Viewfactor experiments at NIF have shed light on both the observed capsule drive deficit and errors in the detailed modelling of hohlraums. The latter could be important factors in the inability to achieve the needed symmetry and energy concentration. The paper then recounts earlier work in Fast Ignition and the uses of pulsed-power for HED and fusion applications. It concludes with a description of a method for improving pulsed-power driven hohlraums that could potentially provide a factor of 10 in energy at NTF-like drive conditions and reach the energy bound for indirect drive ICF.

  9. Cogeneration technology alternatives study. Volume 6: Computer data

    Science.gov (United States)

    1980-01-01

    The potential technical capabilities of energy conversion systems in the 1985 - 2000 time period were defined with emphasis on systems using coal, coal-derived fuels or alternate fuels. Industrial process data developed for the large energy consuming industries serve as a framework for the cogeneration applications. Ground rules for the study were established and other necessary equipment (balance-of-plant) was defined. This combination of technical information, energy conversion system data ground rules, industrial process information and balance-of-plant characteristics was analyzed to evaluate energy consumption, capital and operating costs and emissions. Data in the form of computer printouts developed for 3000 energy conversion system-industrial process combinations are presented.

  10. Propensity Score Analysis: An Alternative Statistical Approach for HRD Researchers

    Science.gov (United States)

    Keiffer, Greggory L.; Lane, Forrest C.

    2016-01-01

    Purpose: This paper aims to introduce matching in propensity score analysis (PSA) as an alternative statistical approach for researchers looking to make causal inferences using intact groups. Design/methodology/approach: An illustrative example demonstrated the varying results of analysis of variance, analysis of covariance and PSA on a heuristic…

  11. SLUDGE TREATMENT PROJECT ALTERNATIVES ANALYSIS SUMMARY REPORT (VOLUME 1)

    International Nuclear Information System (INIS)

    Highly radioactive sludge (containing up to 300,000 curies of actinides and fission products) resulting from the storage of degraded spent nuclear fuel is currently stored in temporary containers located in the 105-K West storage basin near the Columbia River. The background, history, and known characteristics of this sludge are discussed in Section 2 of this report. There are many compelling reasons to remove this sludge from the K-Basin. These reasons are discussed in detail in Section1, and they include the following: (1) Reduce the risk to the public (from a potential release of highly radioactive material as fine respirable particles by airborne or waterborn pathways); (2) Reduce the risk overall to the Hanford worker; and (3) Reduce the risk to the environment (the K-Basin is situated above a hazardous chemical contaminant plume and hinders remediation of the plume until the sludge is removed). The DOE-RL has stated that a key DOE objective is to remove the sludge from the K-West Basin and River Corridor as soon as possible, which will reduce risks to the environment, allow for remediation of contaminated areas underlying the basins, and support closure of the 100-KR-4 operable unit. The environmental and nuclear safety risks associated with this sludge have resulted in multiple legal and regulatory remedial action decisions, plans,and commitments that are summarized in Table ES-1 and discussed in more detail in Volume 2, Section 9

  12. Alternative fuels for vehicles fleet demonstration program. Final report, volume 2: Appendices

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The Alternative Fuels for Vehicles Fleet Demonstration Program (AFV-FDP) was a multiyear effort to collect technical data for use in determining the costs and benefits of alternative-fuel vehicles (AFVs) in typical applications in New York State. This report, Volume 2, includes 13 appendices to Volume 1 that expand upon issues raised therein. Volume 1 provides: (1) Information about the purpose and scope of the AFV-FDP; (2) A summary of AFV-FDP findings organized on the basis of vehicle type and fuel type; (3) A short review of the status of AFV technology development, including examples of companies in the State that are active in developing AFVs and AFV components; and (4) A brief overview of the status of AFV deployment in the State. Volume 3 provides expanded reporting of AFV-FDP technical details, including the complete texts of the brochure Garage Guidelines for Alternative Fuels and the technical report Fleet Experience Survey Report, plus an extensive glossary of AFV terminology. The appendices cover a wide range of issues including: emissions regulations in New York State; production and health effects of ozone; vehicle emissions and control systems; emissions from heavy-duty engines; reformulated gasoline; greenhouse gases; production and characteristics of alternative fuels; the Energy Policy Act of 1992; the Clean Fuel Fleet Program; garage design guidelines for alternative fuels; surveys of fleet managers using alternative fuels; taxes on conventional and alternative fuels; and zero-emission vehicle technology.

  13. Alternatives to peer review: novel approaches for research evaluation

    OpenAIRE

    Aliaksandr eBirukou; Joseph Rushton Wakeling; Claudio eBartolini; Fabio eCasati; Maurizio eMarchese; Katsiaryna eMirylenka; Nardine eOsman; Azzurra eRagone; Carles eSierra; Aalam eWassef

    2011-01-01

    In this paper we review several novel approaches for research evaluation. We start with a brief overview of the peer review, its controversies, and metrics for assessing efficiency and overall quality of the peer review. We then discuss five approaches, including reputation-based ones, that come out of the research carried out by the LiquidPub project and research groups collaborated with LiquidPub. Those approaches are alternative or complementary to traditional peer review. We discuss pros ...

  14. Complementary and alternative medicine approaches in the treatment of PTSD.

    Science.gov (United States)

    Wynn, Gary H

    2015-08-01

    Complementary and alternative medicine is a diverse set of practices and treatments that has seen a significant increase among Americans over the past decade. These approaches have been applied to a myriad of medical and mental health disorders with varying levels of efficacy. Recent years have seen an increased interest in the use of complementary and alternative medicine to address the growing numbers of individuals suffering from post-traumatic stress disorder and other trauma-related disorders. These approaches include pharmacologic and non-pharmacologic modalities. This article will review some of the most widely used non-pharmacologic complementary and alternative medicine practices used to treat post-traumatic stress disorder such as recreational therapy, animal-assisted therapy, yoga, and acupuncture as well as alternative delivery methods for psychotherapy. PMID:26073362

  15. A Comparison of Five Alternative Approaches to Information Systems Development

    Directory of Open Access Journals (Sweden)

    Rudy Hirschheim

    1997-11-01

    Full Text Available The field of information systems (IS has grown dramatically over the past three decades. Recent trends have transformed the IS landscape. These trends include: the evolution of implementation technology from centralized mainframe environments towards distributed client-server architectures, embracing the internet and intranets; changes in user interface technology from character-based to graphical user interfaces, multimedia, and the World Wide Web; changes in applications from transaction processing systems towards systems supporting collaborative work; and the use of information technology as an enabler of business process reengineering and redesign. These technology changes coupled with changes in organizations and their operating environment, such as the growth of the network and virtual organization, internationalization and globalization of many organizations, intensified global competition, changes in values such as customer orientation (service quality and Quality of Working Life, have imposed new demands on the development of information systems. These changes have led to an increasing discussion about information systems development (ISO, and in particular, the various methods, tools, methodologies, and approaches for ISD. We believe such discussion has opened the door for new, alternative IS development approaches and methodologies. Our paper takes up this theme by describing five alternative ISD approaches, namely the Interactionist approach, the Speech Act-based approach, Soft Systems Methodology, the Trade Unionist approach, and the Professional Work Practices approach. Despite the fact that most of these approaches have a history of over 15 years, their relevance to IS development is not well recognized in the mainstream of IS practice and research, nor is their institutional status comparable to traditional approaches such as structured analysis and design methods. Therefore we characterize the five approaches as 'alternative' in

  16. Alternative Contracting and Ownership Approaches for New Nuclear Power Plants

    International Nuclear Information System (INIS)

    This publication examines alternative contracting and ownership approaches for the development, construction, commissioning, operation, and decommissioning of new nuclear power plants. It identifies issues faced by IAEA Member States considering the applicability of such approaches to their respective national programmes. Two new approaches to nuclear project development are analysed. These are, firstly, the Build-Own-Operate (BOO)/Build-Own-Operate-Transfer (BOO(T)) and, secondly, Regional approaches. The information includes practical examples, current practices, and case studies, and reflects the presentations and discussions that took place in a series of IAEA meetings on this topic

  17. Alternatives to peer review: novel approaches for research evaluation

    Directory of Open Access Journals (Sweden)

    Aliaksandr eBirukou

    2011-12-01

    Full Text Available In this paper we review several novel approaches for research evaluation. We start with a brief overview of the peer review, its controversies, and metrics for assessing efficiency and overall quality of the peer review. We then discuss five approaches, including reputation-based ones, that come out of the research carried out by the LiquidPub project and research groups collaborated with LiquidPub. Those approaches are alternative or complementary to traditional peer review. We discuss pros and cons of the proposed approaches and conclude with a vision for the future of the research evaluation, arguing that no single system can suit all stakeholders in various communities.

  18. Feasibility of Quantifying Arterial Cerebral Blood Volume Using Multiphase Alternate Ascending/Descending Directional Navigation (ALADDIN).

    Science.gov (United States)

    Kim, Ki Hwan; Choi, Seung Hong; Park, Sung-Hong

    2016-01-01

    Arterial cerebral blood volume (aCBV) is associated with many physiologic and pathologic conditions. Recently, multiphase balanced steady state free precession (bSSFP) readout was introduced to measure labeled blood signals in the arterial compartment, based on the fact that signal difference between labeled and unlabeled blood decreases with the number of RF pulses that is affected by blood velocity. In this study, we evaluated the feasibility of a new 2D inter-slice bSSFP-based arterial spin labeling (ASL) technique termed, alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in six healthy subjects. A new kinetic model considering bSSFP RF perturbations was proposed to describe the multiphase data and thus to quantify aCBV. Since the inter-slice time delay (TD) and gap affected the distribution of labeled blood spins in the arterial and tissue compartments, we performed the experiments with two TDs (0 and 500 ms) and two gaps (300% and 450% of slice thickness) to evaluate their roles in quantifying aCBV. Comparison studies using our technique and an existing method termed arterial volume using arterial spin tagging (AVAST) were also separately performed in five subjects. At 300% gap or 500-ms TD, significant tissue perfusion signals were demonstrated, while tissue perfusion signals were minimized and arterial signals were maximized at 450% gap and 0-ms TD. ALADDIN has an advantage of visualizing bi-directional flow effects (ascending/descending) in a single experiment. Labeling efficiency (α) of inter-slice blood flow effects could be measured in the superior sagittal sinus (SSS) (20.8±3.7%.) and was used for aCBV quantification. As a result of fitting to the proposed model, aCBV values in gray matter (1.4-2.3 mL/100 mL) were in good agreement with those from literature. Our technique showed high correlation with AVAST, especially when arterial signals were accentuated (i.e., when TD = 0 ms) (r = 0

  19. Alternative Monte Carlo Approach for General Global Illumination

    Institute of Scientific and Technical Information of China (English)

    徐庆; 李朋; 徐源; 孙济洲

    2004-01-01

    An alternative Monte Carlo strategy for the computation of global illumination problem was presented.The proposed approach provided a new and optimal way for solving Monte Carlo global illumination based on the zero variance importance sampling procedure. A new importance driven Monte Carlo global illumination algorithm in the framework of the new computing scheme was developed and implemented. Results, which were obtained by rendering test scenes, show that this new framework and the newly derived algorithm are effective and promising.

  20. Outdoor Education: An Alternative Approach in Teaching and Learning Science

    OpenAIRE

    Tuan Mastura Tuan Soh; Tamby Subahan Mohd. Meerah

    2013-01-01

    To understand fully and aware of children’s science learning, one should look not only at learning that takes place in the kindergarten and primary school but also in learning that takes place outside the classroom. This paper aims to discuss outdoor education: an alternative approach in teaching and learning science in the Malaysian context. In this 21st century, the exposure and experience in the field of science and technology are needed in nurturing interest among students who are involve...

  1. FLUID-BASED SIMULATION APPROACH FOR HIGH VOLUME CONVEYOR TRANSPORTATION SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Ying WANG; Chen ZHOU

    2004-01-01

    High volume conveyor systems in distribution centers have very large footprint and can handle large volumes and hold thousands of items. Traditional discrete-event cell-based approach to simulate such networks becomes computationally challenging. An alternative approach, in which the traffic is represented by segments of fluid flow of different density instead of individual packages, is presented in this paper to address this challenge. The proposed fluid-based simulation approach is developed using a Hybrid Petri Nets framework. The underlying model is a combination of an extension of a Batches Petri Nets (BPN) and a Stochastic Petri Nets (SPN). The extensions are in the inclusion of random elements and relaxation of certain structural constraints. Some adaptations are also made to fit the target system modeling. The approach is presented with an example.

  2. Alternate approaches to vibration and shock analysis using NASTRAN

    Science.gov (United States)

    Denver, R. E.; Menichello, J. M.

    1977-01-01

    A method that derives an approximate equivalent static load to a base excitation shock analysis is described. The transient analysis in the current level of NASTRAN, level 16, does not directly provide for either input acceleration forcing functions or enforced boundary displacement. In the suggested alternate analysis format, equivalent force input functions are applied to the constrained locations by using the artifice of placing a large mass, with respect to the total system mass, at the desired acceleration input points. This shortcut static analysis approach is presented to approximate the expensive and time consuming dynamics analysis approach to the base excitation shock analysis.

  3. Approach for systematic evaluation of transuranic waste management alternatives

    International Nuclear Information System (INIS)

    This paper describes an approach for systematic evaluation of management alternatives that are being considered for the treatment, storage, and disposal of transuranic waste (TRUW) at U.S. Department of Energy sites. The approach, which is currently under development, would apply WASTE-MGMT, a database application model developed at Argonne National Laboratory, to estimate projected environmental releases and would evaluate impact measures such as health risk and costs associated with each of the waste management alternatives. The customized application would combine site-specific TRUW inventory and characterization data with treatment and transportation parameters to estimate the quantities and characteristics of the wastes to be treated, emissions of hazardous substances from the treatment facilities, and the quantities and characteristics of the wastes to be shipped between sites. These data would then be used to estimate for several TRUW management scenarios the costs and health risks of constructing and operating the required treatment facilities and of transporting TRUW for treatment and final disposal. Treatment, storage, and disposal of TRUW at DOE sites is composed of many variables and options at each stage. The approach described in this paper would provide for efficient consideration of all of these facets when evaluating potentially feasible TRUW management alternatives. By expanding existing databases, this model could eventually be adapted to accommodate the introduction of new treatment technologies, updated TRUW characterization data, and/or revised waste acceptance criteria

  4. Data summary of municipal solid waste management alternatives. Volume 2, Exhibits

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    The overall objective of the study in this report was to gather data on waste management technologies to allow comparison of various alternatives for managing municipal solid waste (MSW). The specific objectives of the study were to: 1. Compile detailed data for existing waste management technologies on costs, environmental releases, energy requirements and production, and coproducts such as recycled materials and compost. Identify missing information necessary to make energy, economic, and environmental comparisons of various MSW management technologies, and define needed research that could enhance the usefulness of the technology. 3. Develop a data base that can be used to identify the technology that best meets specific criteria defined by a user of the data base. Volume I contains the report text. Volume II contains supporting exhibits. Volumes III through X are appendices, each addressing a specific MSW management technology. Volumes XI and XII contain project bibliographies.

  5. Hanford spent nuclear fuel project recommended path forward, volume III: Alternatives and path forward evaluation supporting documentation

    Energy Technology Data Exchange (ETDEWEB)

    Fulton, J.C.

    1994-10-01

    Volume I of the Hanford Spent Nuclear Fuel Project - Recommended Path Forward constitutes an aggressive series of projects to construct and operate systems and facilities to safely retrieve, package, transport, process, and store K Basins fuel and sludge. Volume II provided a comparative evaluation of four Alternatives for the Path Forward and an evaluation for the Recommended Path Forward. Although Volume II contained extensive appendices, six supporting documents have been compiled in Volume III to provide additional background for Volume II.

  6. Volume-area scaling approach versus flowline model in glacier volume projections

    NARCIS (Netherlands)

    Radic, V.; Hock, Regine; Oerlemans, J.

    2007-01-01

    Volume–area scaling provides a practical alternative to ice-flow modelling to account for glacier size changes when modelling the future evolution of glaciers; however, uncertainties remain as to the validity of this approach under non-steady conditions. We address these uncertainties by deriving sc

  7. Alternative free volume models and positron cages for the characterisation of nanoporosity in materials

    International Nuclear Information System (INIS)

    Three semi-empirical positron stationary Quantum Models were developed for the study of nanoporosity in a wide range of solid porous materials. The cubic, conic and cylindrical well potentials were considered and their geometric parameters related to the Positron Annihilation LifeTime (PALT) measurements. If a conic or a cubic symmetry is assumed, a resonance lifetime phenomenon was found, which enables proposal of a technique to catch positrons in free volume sites. In the cylindrical case, an alternative method to determine free volume sizes in materials was developed. The free volume equations of these new models were then compared to the well-known and widely utilised Spherical Free Volume Model (SFVM) and remarkable differences were found. A strong variation of the free volume size-positron lifetime relation with the geometry involved was observed and a remarkable dependence of the electron layer thickness parameter ΔR with the hole-shape under study and with the nature of the material considered. The mathematical functions appearing in the conic and cylindrical cases are the superposition of Bessel functions of the first kind and trigonometric functions in the cubic case. Generalised free volume diagrams were constructed and a brief geometrical scheme of the diverse cases considered was obtained. (author)

  8. Efficient volume preserving approach for skeleton-based implicit surfaces

    Institute of Scientific and Technical Information of China (English)

    史红兵; 童若锋; 董金祥

    2003-01-01

    This paper presents an efficient way to preserve the volume of implicit surfaces generated by skeletons. Recursive subdivision is used to efficiently calculate the volume. The criterion for subdivision is obtained by using the property of density functions and treating different types of skeletons respectively to get accurate minimum and maximum distances from a cube to a skeleton. Compared with the criterion generated by other ways such as using traditional Interval Analysis, Affine Arithmetic, or Lipschitz condition, our approach is much better both in speed and accuracy.

  9. Alternative approaches in the conceptualization of social capital

    Directory of Open Access Journals (Sweden)

    Golubović Nataša

    2007-01-01

    Full Text Available Despite the great interest for the concept and a considerable number of papers that deal with the subject of social capital, yet there is no unique and consistent definition of social capital. Forming a consistent theory of social capital is hindered by the presence of several different approaches in the analysis of this phenomenon. Depending on the author’s theoretical position in the definition of social capital or the analysis of its sources, components and outcomes, the emphasis rests on different social processes and relationships. The aim of this paper is to analyze alternative approaches in the conceptualization of social capital, their advantages and shortfalls, and their implications for the development of the social capital theory.

  10. The European Partnership for Alternative Approaches to Animal Testing (EPAA): Promoting Alternative Methods in Europe and Beyond

    OpenAIRE

    Cozigou, Gwenole; Crozier, Jonathan; HENDRIKSEN Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

    2015-01-01

    Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public–private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders....

  11. A multi-criteria approach to camera motion design for volume data animation.

    Science.gov (United States)

    Hsu, Wei-Hsien; Zhang, Yubo; Ma, Kwan-Liu

    2013-12-01

    We present an integrated camera motion design and path generation system for building volume data animations. Creating animations is an essential task in presenting complex scientific visualizations. Existing visualization systems use an established animation function based on keyframes selected by the user. This approach is limited in providing the optimal in-between views of the data. Alternatively, computer graphics and virtual reality camera motion planning is frequently focused on collision free movement in a virtual walkthrough. For semi-transparent, fuzzy, or blobby volume data the collision free objective becomes insufficient. Here, we provide a set of essential criteria focused on computing camera paths to establish effective animations of volume data. Our dynamic multi-criteria solver coupled with a force-directed routing algorithm enables rapid generation of camera paths. Once users review the resulting animation and evaluate the camera motion, they are able to determine how each criterion impacts path generation. In this paper, we demonstrate how incorporating this animation approach with an interactive volume visualization system reduces the effort in creating context-aware and coherent animations. This frees the user to focus on visualization tasks with the objective of gaining additional insight from the volume data.

  12. The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond.

    Science.gov (United States)

    Cozigou, Gwenole; Crozier, Jonathan; Hendriksen, Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

    2015-03-01

    Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public-private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders. Through a brief description of EPAA's activities and organizational structure, we first articulate the value of this collaboration; we then focus on 2 key projects driven by EPAA. The first project aims to address research gaps on stem cells for safety testing, whereas the second project strives for an approach toward demonstration of consistency in vaccine batch release testing. We highlight the growing need for harmonization of international acceptance and implementation of alternative approaches and for increased international collaboration to foster progress on nonanimal alternatives. PMID:25836968

  13. The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond.

    Science.gov (United States)

    Cozigou, Gwenole; Crozier, Jonathan; Hendriksen, Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

    2015-03-01

    Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public-private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders. Through a brief description of EPAA's activities and organizational structure, we first articulate the value of this collaboration; we then focus on 2 key projects driven by EPAA. The first project aims to address research gaps on stem cells for safety testing, whereas the second project strives for an approach toward demonstration of consistency in vaccine batch release testing. We highlight the growing need for harmonization of international acceptance and implementation of alternative approaches and for increased international collaboration to foster progress on nonanimal alternatives.

  14. Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystems Concepts. Volume 3; Program Cost Estimates

    Science.gov (United States)

    Levack, Daniel J. H.

    2000-01-01

    The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F- IA Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results , and the program cost estimates are described in more detail in Volume I - Executive Summary and in individual Final Task Reports.

  15. Alternating Direction Finite Volume Element Methods for Three-Dimensional Parabolic Equations

    Institute of Scientific and Technical Information of China (English)

    Tongke

    2010-01-01

    This paper presents alternating direction finite volume element methods for three-dimensional parabolic partial differential equations and gives four computational schemes, one is analogous to Douglas finite difference scheme with second-order splitting error, the other two schemes have third-order splitting error, and the last one is an extended LOD scheme. The L2 norm and H1 semi-norm error estimates are obtained for the first scheme and second one, respectively. Finally, two numerical examples are provided to illustrate the efficiency and accuracy of the methods.

  16. Alternative Fuel Cycle Evaluation Program. Volume IV. International Fuel Service Center evaluation. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Jacobson, L D [comp.

    1979-11-01

    This Alternative Fuel Cycle Evaluation Program (AFCEP) study presents the technical, economic and social aspects of the International Fuel Service Center (IFSC) as an institutional approach to nuclear fuel cycle development and is provided in support of the Nonproliferation Alternative Systems Assessment program (NASAP). Four types of IFSCs are described and evaluated in terms of three different twenty-year nuclear growth scenarios. Capital costs for each IFSC and comparable dispersed facility costs are discussed. Finally, the possible impact of each scenario and IFSC on the environmental and socio-economic structure is examined. 14 refs., 33 figs., 15 tabs.

  17. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP.

  18. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

    International Nuclear Information System (INIS)

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

  19. A direct renormalization group approach for the excluded volume problem

    International Nuclear Information System (INIS)

    A direct renormalization group approach is proposed, to the excluded volume problem in a square lattice by considering percolating self-avoiding paths in a b x b cell, where b = 2,3. Two ways of counting these paths are presented. In the first one, we get the exponent ν = 0.715 for b = 2 and ν = 0.719 for b = 3, whereas in the second one ν = 0.771 for b = 2 and ν = 0.748 for b = 3. Comments are made on the extrapolation to b → infinite. (Author)

  20. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume I. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. The introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings, and recommendations. Each of Volumes II-VII reports on an individual assessment (Volumn II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP.

  1. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume I. Program summary

    International Nuclear Information System (INIS)

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. The introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings, and recommendations. Each of Volumes II-VII reports on an individual assessment (Volumn II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

  2. Alternative Measuring Approaches in Gamma Scanning on Spent Nuclear Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Sihm Kvenangen, Karen

    2007-06-15

    In the future, the demand for energy is predicted to grow and more countries plan to utilize nuclear energy as their source of electric energy. This gives rise to many important issues connected to nuclear energy, such as finding methods that can verify that the spent nuclear fuel has been handled safely and used in ordinary power producing cycles as stated by the operators. Gamma ray spectroscopy is one method used for identification and verification of spent nuclear fuel. In the specific gamma ray spectroscopy method called gamma scanning the gamma radiation from the fission products Cs-137, Cs-134 and Eu-154 are measured in a spent fuel assembly. From the results, conclusions can be drawn about the fuels characteristics. This degree project examines the possibilities of using alternative measuring approaches when using the gamma scanning method. The focus is on examining how to increase the quality of the measured data. How to decrease the measuring time as compared with the present measuring strategy, has also been investigated. The main part of the study comprises computer simulations of gamma scanning measurements. The simulations have been validated with actual measurements on spent nuclear fuel at the central interim storage, Clab. The results show that concerning the quality of the measuring data the conventional strategy is preferable, but with other starting positions and with a more optimized equipment. When focusing on the time aspect, the helical measuring strategy can be an option, but this needs further investigation.

  3. An Alternate Approach to Alternating Sums: A Method to DIE for

    Science.gov (United States)

    Benjamin, Arthur T.; Quinn, Jennifer J.

    2008-01-01

    Positive sums count. Alternating sums match. Alternating sums of binomial coefficients, Fibonacci numbers, and other combinatorial quantities are analyzed using sign-reversing involutions. In particular, we describe the quantity being considered, match positive and negative terms through an Involution, and count the Exceptions to the matching rule…

  4. New Approach for Error Reduction in the Volume Penalization Method

    CERN Document Server

    Iwakami-Nakano, Wakana; Hatakeyama, Nozomu; Hattori, Yuji

    2012-01-01

    The volume penalization method offers an efficient way to numerically simulate flows around complex-shaped bodies which move and/or deform in general. In this method a penalization term which has permeability eta and a mask function is added to a governing equation as a forcing term in order to impose different dynamics in solid and fluid regions. In this paper we investigate the accuracy of the volume penalization method in detail. We choose the one-dimensional Burgers' equation as a governing equation since it enables us extensive study and it has a nonlinear term similar to the Navier-Stokes equations. It is confirmed that the error which consists of the discretization/truncation error, the penalization error, the round-off error, and others has the same features as those in previous results when we use the standard definition of the mask function. As the number of grid points increases, the error converges to a non-zero constant which is equal to the penalization error. We propose a new approach for reduc...

  5. Preliminary evaluation of alternative waste form solidification processes. Volume II. Evaluation of the processes

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    This Volume II presents engineering feasibility evaluations of the eleven processes for solidification of nuclear high-level liquid wastes (HHLW) described in Volume I of this report. Each evaluation was based in a systematic assessment of the process in respect to six principal evaluation criteria: complexity of process; state of development; safety; process requirements; development work required; and facility requirements. The principal criteria were further subdivided into a total of 22 subcriteria, each of which was assigned a weight. Each process was then assigned a figure of merit, on a scale of 1 to 10, for each of the subcriteria. A total rating was obtained for each process by summing the products of the subcriteria ratings and the subcriteria weights. The evaluations were based on the process descriptions presented in Volume I of this report, supplemented by information obtained from the literature, including publications by the originators of the various processes. Waste form properties were, in general, not evaluated. This document describes the approach which was taken, the developent and application of the rating criteria and subcriteria, and the evaluation results. A series of appendices set forth summary descriptions of the processes and the ratings, together with the complete numerical ratings assigned; two appendices present further technical details on the rating process.

  6. Preliminary evaluation of alternative waste form solidification processes. Volume II. Evaluation of the processes

    International Nuclear Information System (INIS)

    This Volume II presents engineering feasibility evaluations of the eleven processes for solidification of nuclear high-level liquid wastes (HHLW) described in Volume I of this report. Each evaluation was based in a systematic assessment of the process in respect to six principal evaluation criteria: complexity of process; state of development; safety; process requirements; development work required; and facility requirements. The principal criteria were further subdivided into a total of 22 subcriteria, each of which was assigned a weight. Each process was then assigned a figure of merit, on a scale of 1 to 10, for each of the subcriteria. A total rating was obtained for each process by summing the products of the subcriteria ratings and the subcriteria weights. The evaluations were based on the process descriptions presented in Volume I of this report, supplemented by information obtained from the literature, including publications by the originators of the various processes. Waste form properties were, in general, not evaluated. This document describes the approach which was taken, the developent and application of the rating criteria and subcriteria, and the evaluation results. A series of appendices set forth summary descriptions of the processes and the ratings, together with the complete numerical ratings assigned; two appendices present further technical details on the rating process

  7. SU-E-J-35: Using CBCT as the Alternative Method of Assessing ITV Volume

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Y; Turian, J; Templeton, A; Redler, G; Chu, J [Rush University Medical Center, Chicago, IL (United States)

    2015-06-15

    Purpose To study the accuracy of Internal Target Volumes (ITVs) created on cone beam CT (CBCT) by comparing the visible target volume on CBCT to volumes (GTV, ITV, and PTV) outlined on free breathing (FB) CT and 4DCT. Methods A Quasar Cylindrical Motion Phantom with a 3cm diameter ball (14.14 cc) embedded within a cork insert was set up to simulate respiratory motion with a period of 4 seconds and amplitude of 2cm superioinferiorly and 1cm anterioposteriorly. FBCT and 4DCT images were acquired. A PTV-4D was created on the 4DCT by applying a uniform margin of 5mm to the ITV-CT. PTV-FB was created by applying a margin of the motion range plus 5mm, i.e. total of 1.5cm laterally and 2.5cm superioinferiorly to the GTV outlined on the FBCT. A dynamic conformal arc was planned to treat the PTV-FB with 1mm margin. A CBCT was acquired before the treatment, on which the target was delineated. During the treatment, the position of the target was monitored using the EPID in cine mode. Results ITV-CBCT and ITV-CT were measured to be 56.6 and 62.7cc, respectively, with a Dice Coefficient (DC) of 0.94 and disagreement in center of mass (COM) of 0.59 mm. On the other hand, GTV-FB was 11.47cc, 19% less than the known volume of the ball. PTV-FB and PTV-4D were 149 and 116 cc, with a DC of 0.71. Part of the ITV-CT was not enclosed by the PTV-FB despite the large margin. The cine EPID images have confirmed geometrical misses of the target. Similar under-coverage was observed in one clinical case and captured by the CBCT, where the implanted fiducials moved outside PTV-FB. Conclusion ITV-CBCT is in good agreement with ITV-CT. When 4DCT was not available, CBCT can be an effective alternative in determining and verifying the PTV margin.

  8. A Rule Based Approach to ISS Interior Volume Control and Layout

    Science.gov (United States)

    Peacock, Brian; Maida, Jim; Fitts, David; Dory, Jonathan

    2001-01-01

    Traditional human factors design involves the development of human factors requirements based on a desire to accommodate a certain percentage of the intended user population. As the product is developed human factors evaluation involves comparison between the resulting design and the specifications. Sometimes performance metrics are involved that allow leniency in the design requirements given that the human performance result is satisfactory. Clearly such approaches may work but they give rise to uncertainty and negotiation. An alternative approach is to adopt human factors design rules that articulate a range of each design continuum over which there are varying outcome expectations and interactions with other variables, including time. These rules are based on a consensus of human factors specialists, designers, managers and customers. The International Space Station faces exactly this challenge in interior volume control, which is based on anthropometric, performance and subjective preference criteria. This paper describes the traditional approach and then proposes a rule-based alternative. The proposed rules involve spatial, temporal and importance dimensions. If successful this rule-based concept could be applied to many traditional human factors design variables and could lead to a more effective and efficient contribution of human factors input to the design process.

  9. An Alternative Approach for the Determination of Soil Water Mobility

    Institute of Scientific and Technical Information of China (English)

    M.P.C.ENGLER; R.CICHOTA; Q.DE JONG VAN LIER; E.M.BLOEM; G.SPAROVEK; E. SCHNUG

    2008-01-01

    A new laboratory method was proposed to establish an easily performed standard for the determination of mobile soil water close to real conditions during the infiltration and redistribution of water in a soil.It consisted of applying a water volume with a tracer ion on top of an undisturbed ring sample on a pressure plate under a known suction or pressure head.Afterwards,soil water mobility was determined by analyzing the tracer-ion concentration in the soil sample.Soil water mobility showed to be a function of the applied water volume.No relation between soil water mobility and applied pressure head could be established with data from the present experiment.A simple one- or two-parameter equation can be fitted to the experimental data to parameterize soil water mobility as a function of applied solute volume.Sandy soils showed higher mobility than loamy soils at low values of applied solute volumes,and both sandy and loamy soils showed an almost complete mobility at high applied solute volumes.

  10. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 2. Alternatives for waste treatment

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume II of the five-volume report is devoted to the description of alternatives for waste treatment. The discussion is presented under the following section titles: fuel reprocessing modifications; high-level liquid waste solidification; treatment and immobilization of chop-leach fuel bundle residues; treatment of noncombustible solid wastes; treatment of combustible wastes; treatment of non-high-level liquid wastes; recovery of transuranics from non-high-level wastes; immobilization of miscellaneous non-high-level wastes; volatile radioisotope recovery and off-gas treatment; immobilization of volatile radioisotopes; retired facilities (decontamination and decommissioning); and, modification and use of selected fuel reprocessing wastes. (JGB)

  11. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 2. Alternatives for waste treatment

    International Nuclear Information System (INIS)

    Volume II of the five-volume report is devoted to the description of alternatives for waste treatment. The discussion is presented under the following section titles: fuel reprocessing modifications; high-level liquid waste solidification; treatment and immobilization of chop-leach fuel bundle residues; treatment of noncombustible solid wastes; treatment of combustible wastes; treatment of non-high-level liquid wastes; recovery of transuranics from non-high-level wastes; immobilization of miscellaneous non-high-level wastes; volatile radioisotope recovery and off-gas treatment; immobilization of volatile radioisotopes; retired facilities (decontamination and decommissioning); and, modification and use of selected fuel reprocessing wastes

  12. The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Olga eVoevodskaya

    2014-10-01

    Full Text Available In neurodegeneration research, normalization of regional volumes by intracranial volume (ICV is important to estimate the extent of disease-driven atrophy. There is little agreement as to whether raw volumes, volume-to-ICV fractions or regional volumes from which the ICV factor has been regressed out should be used for volumetric brain imaging studies. Using multiple regional cortical and subcortical volumetric measures generated by Freesurfer (51 in total, the main aim of this study was to elucidate the implications of these adjustment approaches. Magnetic resonance imaging (MRI data were analyzed from two large cohorts, the population-based PIVUS cohort (N=406, all subjects age 75 and the Alzheimer disease Neuroimaging Initiative (ADNI cohort (N=724. Further, we studied whether the chosen ICV normalization approach influenced the relationship between hippocampus and cognition in the three diagnostic groups of the ADNI cohort (Alzheimer’s disease, mild cognitive impairment and healthy individuals. The ability of raw vs adjusted hippocampal volumes to predict diagnostic status was also assessed. In both cohorts raw volumes correlate positively with ICV, but do not scale directly proportionally with it. The correlation direction is reversed for all volume-to-ICV fractions, except the lateral and third ventricles. Most grey matter fractions are larger in females, while lateral ventricle fractions are greater in males. Residual correction effectively eliminated the correlation between the regional volumes and ICV and removed gender differences. The association between hippocampal volumes and cognition was not altered by ICV normalization. Comparing prediction of diagnostic status using the different approaches, small but significant differences were found. The choice of normalization approach should be carefully considered when designing a volumetric brain imaging study.

  13. Alternative approaches to research in physical therapy: positivism and phenomenology.

    Science.gov (United States)

    Shepard, K F; Jensen, G M; Schmoll, B J; Hack, L M; Gwyer, J

    1993-02-01

    This article presents philosophical approaches to research in physical therapy. A comparison is made to demonstrate how the research purpose, research design, research methods, and research data differ when one approaches research from the philosophical perspective of positivism (predominantly quantitative) as compared with the philosophical perspective of phenomenology (predominantly qualitative). Differences between the two approaches are highlighted by examples from research articles published in Physical Therapy. The authors urge physical therapy researchers to become familiar with the tenets, rigor, and knowledge gained from the use of both approaches in order to increase their options in conducting research relevant to the practice of physical therapy. PMID:8421722

  14. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Volume II assesses proliferation resistance. Chapters are devoted to: assessment of civilian nuclear systems (once-through fuel-cycle systems, closed fuel cycle systems, research reactors and critical facilities); assessment of associated sensitive materials and facilities (enrichment, problems with storage of spent fuel and plutonium content, and reprocessing and refabrication facilities); and safeguards for alternative fuel cycles.

  15. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    International Nuclear Information System (INIS)

    Volume II assesses proliferation resistance. Chapters are devoted to: assessment of civilian nuclear systems (once-through fuel-cycle systems, closed fuel cycle systems, research reactors and critical facilities); assessment of associated sensitive materials and facilities (enrichment, problems with storage of spent fuel and plutonium content, and reprocessing and refabrication facilities); and safeguards for alternative fuel cycles

  16. Complementary and Alternative Approaches to Pain Relief during Labor

    Directory of Open Access Journals (Sweden)

    Michel Tournaire

    2007-01-01

    Full Text Available This review evaluated the effect of complementary and alternative medicine on pain during labor with conventional scientific methods using electronic data bases through 2006 were used. Only randomized controlled trials with outcome measures for labor pain were kept for the conclusions. Many studies did not meet the scientific inclusion criteria. According to the randomized control trials, we conclude that for the decrease of labor pain and/or reduction of the need for conventional analgesic methods: (i There is an efficacy found for acupressure and sterile water blocks. (ii Most results favored some efficacy for acupuncture and hydrotherapy. (iii Studies for other complementary or alternative therapies for labor pain control have not shown their effectiveness.

  17. Math Games - an alternative (approach) to math education?

    OpenAIRE

    Ruttkay, Zsófia; Eliëns, Anton; Breitlauch, L.

    2009-01-01

    Getting students to read, digest and practice material is difficult in any discipline, but even more so for math, since many students have to cope with motivational problems and feelings of inadequacy, often due to prior unsuccesful training and teaching methods. In this paper we look at the opportunities offered by computer graphics, visual programming and game design as an alternative for traditional methods of teaching mathemathics. In particular, games may be deployed both as intruments to d...

  18. Towards a Strategic Approaches in Alternative Tests for Pesticide Safety

    OpenAIRE

    Jang, Yoonjeong; Kim, Ji-Eun; Jeong, Sang-Hee; Cho, Myung-Haing

    2014-01-01

    Pesticides have provided significant benefits including plant disease control and increased crop yields since people developed and utilized them. However, pesticide use is associated with many adverse effects, which necessitate precise toxicological tests and risk assessment. Most of these methods are based on animal studies, but considerations of animal welfare and ethics require the development of alternative methods for the evaluation of pesticide toxicity. Although the usage of laboratory...

  19. School District Program Cost Accounting: An Alternative Approach

    Science.gov (United States)

    Hentschke, Guilbert C.

    1975-01-01

    Discusses the value for school districts of a program cost accounting system and examines different approaches to generating program cost data, with particular emphasis on the "cost allocation to program system" (CAPS) and the traditional "transaction-based system." (JG)

  20. Teaching about Radioactivity and Ionising Radiation: An Alternative Approach.

    Science.gov (United States)

    Millar, Robin; And Others

    1990-01-01

    Children's ideas about radiation and radioactivity are reviewed and several common areas of misunderstanding are identified. An approach to teaching the topic at the secondary school level which seeks to specifically address known difficulties is outlined. (CW)

  1. Alternating chemo-radiotherapy in bladder cancer: A conservative approach

    Energy Technology Data Exchange (ETDEWEB)

    Orsatti, M.; Franzone, P.; Giudici, S. [Istituto Nazionale per la Ricerca sul Cancro, Genova (Switzerland)] [and others

    1995-08-30

    The aim of this Phase II study was to determine a bladder-sparing treatment in patients with invasive bladder cancer, allowing a better quality of life. Objectives were to test toxicity and disease-free and overall survival of patients given an alternated chemo-radiotherapy definitive treatment. Seventy-six patients with bladder cancer Stage T1G3 through T4 N0 M0 were entered in the same chemotherapy regimen (Cisplatin 20 mg/mq and 5-Fluorouracil 200 mg/mq daily for 5 days) alternated with different radiotherapy scheduling, the first 18 patients received two cycles of 20 Gy/10 fractions/12 days each; the second group of 58 patients received two cycles of 25 Gy/10 fractions/12 days each (the last 21 patients received Methotrexate 40 mg/mq instead of 5-Fluorouracil). A clinical complete response was observed in 57 patients (81%), partial response in 7 patients (10%), and a nonresponse in 6 patients (9%). At a median follow-up of 45 months, 33 patients (47%) were alive and free of tumor. The 6-year overall survival and progression-free survival was 42% and 40%, respectively. Systemic side effects were mild, while a moderate or severe local toxicity was observed in 14 patients and 13 patients (about 20%), respectively. Our conservative combination treatment allowed bladder-sparing in a high rate of patients and resulted in a survival comparable to that reported after radical cystectomy. 34 refs., 4 figs., 5 tabs.

  2. The alternative Pharaoh approach: stingless bees mummify beetle parasites alive

    Science.gov (United States)

    Greco, Mark K.; Hoffmann, Dorothee; Dollin, Anne; Duncan, Michael; Spooner-Hart, Robert; Neumann, Peter

    2010-03-01

    Workers from social insect colonies use different defence strategies to combat invaders. Nevertheless, some parasitic species are able to bypass colony defences. In particular, some beetle nest invaders cannot be killed or removed by workers of social bees, thus creating the need for alternative social defence strategies to ensure colony survival. Here we show, using diagnostic radioentomology, that stingless bee workers ( Trigona carbonaria) immediately mummify invading adult small hive beetles ( Aethina tumida) alive by coating them with a mixture of resin, wax and mud, thereby preventing severe damage to the colony. In sharp contrast to the responses of honeybee and bumblebee colonies, the rapid live mummification strategy of T. carbonaria effectively prevents beetle advancements and removes their ability to reproduce. The convergent evolution of mummification in stingless bees and encapsulation in honeybees is another striking example of co-evolution between insect societies and their parasites.

  3. Testing and assessment strategies, including alternative and new approaches.

    Science.gov (United States)

    Meyer, Otto

    2003-04-11

    The object of toxicological testing is to predict possible adverse effect in humans when exposed to chemicals whether used as industrial chemicals, pharmaceuticals or pesticides. Animal models are predominantly used in identifying potential hazards of chemicals. The use of laboratory animals raises ethical concern. However, irrespective of animal welfare it is an important aspect of the discipline of toxicology that the primary object is human health. The ideal testing and assessment strategy is simple to use all the available test methods and preferably more in laboratory animal species from which we get as many data as possible in order to obtain the most extensive database for the toxicological evaluation of a chemical. Consequently, the society has decided that certain group of chemicals should be tested accordingly. However, realising that, this idea is not obtainable in practice because there are more than 100000 chemicals which are potential for human exposure, so the development of alternative testing and assessment strategies has taken place in the recent years. The toxicological evaluation should enable the society to cope with the simultaneous requirement of many chemicals for different uses and of the absence of health problems involved with their use. Thus, the regulatory toxicology is a cocktail of science and pragmatism added a crucial concern for animal welfare. Test methods are most often used in a testing sequence as bricks in a testing strategy. The main key driving forces for introducing assessment and testing strategies e.g. using a limited number of tests and/or alternative test methods are: (a) animal welfare considerations; (b) new scientific knowledge i.e. introducing tests for new endpoints and tests for better understanding of mode of action; and (c) lack of testing capacity/reduction of required resources economically as well as time wise. PMID:12676447

  4. Taxation of Fringe Benefits: Alternative Approaches to Current Problems.

    Science.gov (United States)

    Cohen, Anita E.

    1979-01-01

    The current IRS tax treatment of fringe benefits is seen as inadequate, and the judicial precept confusing, because groups of employee benefits are inappropriately excluded from taxation as perquisites. A tax equalization approach is proposed. Available from Suffolk University Law Review Office, 41 Temple St., Boston, MA 02114. (MSE)

  5. Sequential Bayesian technique: An alternative approach for software reliability estimation

    Indian Academy of Sciences (India)

    S Chatterjee; S S Alam; R B Misra

    2009-04-01

    This paper proposes a sequential Bayesian approach similar to Kalman filter for estimating reliability growth or decay of software. The main advantage of proposed method is that it shows the variation of the parameter over a time, as new failure data become available. The usefulness of the method is demonstrated with some real life data

  6. Modeling Health Insurance Expansions: Effects of Alternate Approaches

    Science.gov (United States)

    Remler, Dahlia K.; Zivin, Joshua Graff; Glied, Sherry A.

    2004-01-01

    Estimates of the costs and consequences of many types of public policy proposals play an important role in the development and adoption of particular policy programs. Estimates of the same, or similar, policies that employ different modeling approaches can yield widely divergent results. Such divergence often undermines effective policymaking.…

  7. Counselling--Alternative Approaches. Information Bank Working Paper No. 2476.

    Science.gov (United States)

    Brookes, Jeannie

    This document looks at various types of counseling approaches and includes sections on Rogerian counseling, Gestalt therapy, and rational emotive therapy. The section on Rogerian counseling includes a discussion of the principles of counseling from Rogers'"Client Centered Therapy." Gestalt therapy is explained in more detail and a synopsis is…

  8. Supplemental/Replacement: An Alternative Approach to Excess Costs.

    Science.gov (United States)

    Hartman, William T.

    1990-01-01

    This article proposes a new operational definition of excess cost in determining state and federal funding for special education. The new approach is based on programs and services rather than accounting calculations of the difference between special education cost per student and regular education cost per student. (Author/DB)

  9. Erythrocytes labeled with [(18) F]SFB as an alternative to radioactive CO for quantification of blood volume with PET.

    Science.gov (United States)

    Herance, José Raúl; Gispert, Juan Domingo; Abad, Sergio; Victor, Victor M; Pareto, Deborah; Torrent, Èlia; Rojas, Santiago

    2013-01-01

    Inhaled radioactive CO is currently the tracer of choice for blood volume quantification by positron emission tomography (PET). This measurement is of great interest for several clinical and research applications. However, owing to the short half-life of the radiolabeled CO, it can only be used in centers equipped with a cyclotron. In the present work, we propose an alternative method to label the red blood cells with [(18) F] in order to obtain blood volume measurements by PET. The use of the radioactive synthon [(18) F] N-succinimidyl 4-[(18) F]fluorobenzoate ([(18) F]SFB) was evaluated for erythrocyte labeling and PET blood volume imaging. The images provided by [(18) F]SFB labeled erythrocytes were compared with those obtained with inhaled [(11) C]CO. Blood volumes obtained with [(18) F]SFB labeled erythrocytes were similar to those obtained with [(11) C]CO in all of the evaluated organs with the exception of spleen, which presented lower uptake with this method. Since the [(18) F]-SFB binds irreversibly to red blood cells, in vivo stability of the radiolabel was higher compared with the [(11) C]CO method. Additionally, owing to the longer half-life and the shorter positron range of [(18) F], the image quality was also higher with the [(18) F]SFB radiolabeled erythrocytes. The labeling of red blood with [(18) F]SFB represents an advantageous alternative to radioactive CO for blood volume measurement by PET and cardiovascular isotopic imaging.

  10. A unified approach to Mimetic Finite Difference, Hybrid Finite Volume and Mixed Finite Volume methods

    OpenAIRE

    Droniou, Jerome; Eymard,, Robert; Gallouët, Thierry; Herbin, Raphaele

    2008-01-01

    International audience We investigate the connections between several recent methods for the discretization of ani\\-so\\-tropic heterogeneous diffusion operators on general grids. We prove that the Mimetic Finite Difference scheme, the Hybrid Finite Volume scheme and the Mixed Finite Volume scheme are in fact identical up to some slight generalizations. As a consequence, some of the mathematical results obtained for each of the method (such as convergence properties or error estimates) may ...

  11. The machine paradigm and alternative approaches in cognitive science.

    Science.gov (United States)

    Barutta, Joaquín; Aravena, Pía; Ibáñez, Agustín

    2010-06-01

    In a recent paper called To think human out of the machine paradigm, it is stated that psychological science operates within a machine paradigm that is committed to mechanical causality. In addition, it is emphasizes the epistemological and methodological limitations of explanations based in deterministic mechanics and instead argues for the need of an 'organic paradigm' that takes into consideration psychological processes such as subjectivity, inter-subjectivity, and agency. Although there is no doubt that much psychological science has operated under a machine paradigm, we argue that recent psychological research is pursued using a wide variety of approaches and with an absence of a partially integrated meta-theoretical corpus. The present situation looks more like a Tower of Babel of epistemological approaches and empirical programs. The reconsideration of the organic paradigm and an explicitly addressed epistemological framework could constitute a step forward and lead to an explanatory pluralism built on greater dialogue within the psychological sciences. PMID:20306344

  12. An ecological approach to language development: an alternative functionalism.

    Science.gov (United States)

    Dent, C H

    1990-11-01

    I argue for a new functionalist approach to language development, an ecological approach. A realist orientation is used that locates the causes of language development neither in the child nor in the language environment but in the functioning of perceptual systems that detect language-world relationships and use them to guide attention and action. The theory requires no concept of innateness, thus avoiding problems inherent in either the innate ideas or the genes-as-causal-programs explanations of the source of structure in language. An ecological explanation of language is discussed in relation to concepts and language, language as representation, problems in early word learning, metaphor, and syntactic development. Finally, problems incurred in using the idea of innateness are summarized: History prior to the chosen beginning point is ignored, data on organism-environment mutuality are not collected, and the explanation claims no effect of learning, which cannot be tested empirically.

  13. Alternative Approaches for Rating INDCs: a Comparative Analysis

    OpenAIRE

    Davide, Marinella; Vesco, Paola

    2016-01-01

    The “Intended nationally determined contributions” (INDCs) communicated by both developing and developed countries represent a crucial element of the Paris agreement. This paper aims at analysing the INDCs submitted by Parties, through the different tools and approaches proposed by the research community. In particular, our analysis looks at the different ways to assess the effectiveness of the proposed emission reduction pledges, both in terms of aggregate and national efforts. However, we a...

  14. Mechanistic approaches and the development of alternative toxicity test methods.

    OpenAIRE

    Balls, M

    1998-01-01

    A mechanism can be defined as an explanation of an observed phenomenon that explains the processes underlying the phenomenon in terms of events at lower levels of organization. A prerequisite for new, more mechanistic, approaches, which would use in vitro systems rather than conventional animal analogy models, is a strengthening of the underlying scientific basis of toxicity testing. This will require greater recognition of the differences between fidelity and discrimination models and betwee...

  15. Eigenvalues from power-series expansions: an alternative approach

    Energy Technology Data Exchange (ETDEWEB)

    Amore, Paolo [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Colima, Colima (Mexico); Fernandez, Francisco M [INIFTA (UNLP, CCT La Plata-CONICET), Division Quimica Teorica, Diag. 113 y 64 (S/N), Sucursal 4, Casilla de Correo 16, 1900 La Plata (Argentina)], E-mail: paolo.amore@gmail.com, E-mail: fernande@quimica.unlp.edu.ar

    2009-02-20

    An appropriate rational approximation to the eigenfunction of the Schroedinger equation for anharmonic oscillators enables one to obtain the eigenvalue accurately as the limit of a sequence of roots of Hankel determinants. The convergence rate of this approach is greater than that for a well-established method based on power-series expansions weighted by a Gaussian factor with an adjustable parameter (the so-called Hill-determinant method)

  16. Multidimensional Programming Methods for Energy Facility Siting: Alternative Approaches

    Science.gov (United States)

    Solomon, B. D.; Haynes, K. E.

    1982-01-01

    The use of multidimensional optimization methods in solving power plant siting problems, which are characterized by several conflicting, noncommensurable objectives is addressed. After a discussion of data requirements and exclusionary site screening methods for bounding the decision space, classes of multiobjective and goal programming models are discussed in the context of finite site selection. Advantages and limitations of these approaches are highlighted and the linkage of multidimensional methods with the subjective, behavioral components of the power plant siting process is emphasized.

  17. UAV-based NDVI calculation over grassland: An alternative approach

    Science.gov (United States)

    Mejia-Aguilar, Abraham; Tomelleri, Enrico; Asam, Sarah; Zebisch, Marc

    2016-04-01

    The Normalised Difference Vegetation Index (NDVI) is one of the most widely used indicators for monitoring and assessing vegetation in remote sensing. The index relies on the reflectance difference between the near infrared (NIR) and red light and is thus able to track variations of structural, phenological, and biophysical parameters for seasonal and long-term monitoring. Conventionally, NDVI is inferred from space-borne spectroradiometers, such as MODIS, with moderate resolution up to 250 m ground resolution. In recent years, a new generation of miniaturized radiometers and integrated hyperspectral sensors with high resolution became available. Such small and light instruments are particularly adequate to be mounted on airborne unmanned aerial vehicles (UAV) used for monitoring services reaching ground sampling resolution in the order of centimetres. Nevertheless, such miniaturized radiometers and hyperspectral sensors are still very expensive and require high upfront capital costs. Therefore, we propose an alternative, mainly cheaper method to calculate NDVI using a camera constellation consisting of two conventional consumer-grade cameras: (i) a Ricoh GR modified camera that acquires the NIR spectrum by removing the internal infrared filter. A mounted optical filter additionally obstructs all wavelengths below 700 nm. (ii) A Ricoh GR in RGB configuration using two optical filters for blocking wavelengths below 600 nm as well as NIR and ultraviolet (UV) light. To assess the merit of the proposed method, we carry out two comparisons: First, reflectance maps generated by the consumer-grade camera constellation are compared to reflectance maps produced with a hyperspectral camera (Rikola). All imaging data and reflectance maps are processed using the PIX4D software. In the second test, the NDVI at specific points of interest (POI) generated by the consumer-grade camera constellation is compared to NDVI values obtained by ground spectral measurements using a

  18. An alternative subspace approach to EEG dipole source localization

    Science.gov (United States)

    Xu, Xiao-Liang; Xu, Bobby; He, Bin

    2004-01-01

    In the present study, we investigate a new approach to electroencephalography (EEG) three-dimensional (3D) dipole source localization by using a non-recursive subspace algorithm called FINES. In estimating source dipole locations, the present approach employs projections onto a subspace spanned by a small set of particular vectors (FINES vector set) in the estimated noise-only subspace instead of the entire estimated noise-only subspace in the case of classic MUSIC. The subspace spanned by this vector set is, in the sense of principal angle, closest to the subspace spanned by the array manifold associated with a particular brain region. By incorporating knowledge of the array manifold in identifying FINES vector sets in the estimated noise-only subspace for different brain regions, the present approach is able to estimate sources with enhanced accuracy and spatial resolution, thus enhancing the capability of resolving closely spaced sources and reducing estimation errors. The present computer simulations show, in EEG 3D dipole source localization, that compared to classic MUSIC, FINES has (1) better resolvability of two closely spaced dipolar sources and (2) better estimation accuracy of source locations. In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist.

  19. An alternative subspace approach to EEG dipole source localization

    International Nuclear Information System (INIS)

    In the present study, we investigate a new approach to electroencephalography (EEG) three-dimensional (3D) dipole source localization by using a non-recursive subspace algorithm called FINES. In estimating source dipole locations, the present approach employs projections onto a subspace spanned by a small set of particular vectors (FINES vector set) in the estimated noise-only subspace instead of the entire estimated noise-only subspace in the case of classic MUSIC. The subspace spanned by this vector set is, in the sense of principal angle, closest to the subspace spanned by the array manifold associated with a particular brain region. By incorporating knowledge of the array manifold in identifying FINES vector sets in the estimated noise-only subspace for different brain regions, the present approach is able to estimate sources with enhanced accuracy and spatial resolution, thus enhancing the capability of resolving closely spaced sources and reducing estimation errors. The present computer simulations show, in EEG 3D dipole source localization, that compared to classic MUSIC, FINES has (1) better resolvability of two closely spaced dipolar sources and (2) better estimation accuracy of source locations. In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist

  20. An alternative subspace approach to EEG dipole source localization

    Energy Technology Data Exchange (ETDEWEB)

    Xu Xiaoliang [KC Science and Technologies Inc., Naperville, IL 60565 (United States); Xu, Bobby [Illinois Mathematics and Science Academy, Aurora, IL 60506 (United States); He Bin [Department of Bioengineering, University of Illinois, Chicago, IL 60607 (United States)

    2004-01-21

    In the present study, we investigate a new approach to electroencephalography (EEG) three-dimensional (3D) dipole source localization by using a non-recursive subspace algorithm called FINES. In estimating source dipole locations, the present approach employs projections onto a subspace spanned by a small set of particular vectors (FINES vector set) in the estimated noise-only subspace instead of the entire estimated noise-only subspace in the case of classic MUSIC. The subspace spanned by this vector set is, in the sense of principal angle, closest to the subspace spanned by the array manifold associated with a particular brain region. By incorporating knowledge of the array manifold in identifying FINES vector sets in the estimated noise-only subspace for different brain regions, the present approach is able to estimate sources with enhanced accuracy and spatial resolution, thus enhancing the capability of resolving closely spaced sources and reducing estimation errors. The present computer simulations show, in EEG 3D dipole source localization, that compared to classic MUSIC, FINES has (1) better resolvability of two closely spaced dipolar sources and (2) better estimation accuracy of source locations. In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist.

  1. Corporate finance in an interest free economy: An alternate approach to practiced Islamic Corporate Finance

    OpenAIRE

    Shaikh, Salman

    2009-01-01

    This paper suggests an alternate approach to corporate finance in an interest free economy by looking beyond practiced Islamic finance and suggesting alternatives for corporate finance in sourcing funds i.e. i) Ijara with embedded options, ii) limited liability partnership, iii) equity modes like Musharakah and Mudarabah iv) income bonds and v) convertible income bonds. It also suggests alternatives for corporate finance in using funds i.e. i) Islamic income funds, ii) Islamic REITs, iii) Tre...

  2. Schwinger-boson approach to anisotropy ferrimagnetic chain with bond alternation

    Institute of Scientific and Technical Information of China (English)

    李殷翔; 陈斌

    2015-01-01

    We use the Schwinger-boson approach to study the anisotropy ferrimagnetic spin-(1/2,1) chain with bond alternation. Based on the effect of bond alternationδ, we obtain energy gap, free energy, and specific heat, respectively. The specific heat with larger bond alternation (δ >0.7) displays a peak at low temperature. Based on the effect of X X Z anisotropy parameter∆, we present excited spectrums, free energy, and specific heat, respectively.

  3. Reverse Flipping Technique: An Alternate Approach to Tie Reversing Half-Hitches on Alternating Posts.

    Science.gov (United States)

    Chong, Alexander C M; Prohaska, Daniel J; Pate, Ryan C

    2016-04-01

    Arthroscopic knot tying requires practice and attention to detail, especially tying the 3 reversing half-hitches on alternating posts (RHAPs) in a knot. Mistakes can occur that result in an unintentional tension (>10 N) applied to the wrapping suture limb, and by placing tension in the wrong limb, the previously "flipped" half-hitch is converted from a series of RHAPs into a series of identical half-hitches on the same post, thereby producing insecure knots or suture loops. This was hypothesized to be a source of knot failure by knot slippage. This error can be avoided by using a technique we describe as "reverse flipping," which purposely "flips" the half-hitch down at the main knot while tying the 3 RHAPs in a knot, and then the half-hitch is retightened using either a past-pointing or over-pointing technique. This way the surgeon can be absolutely sure that the half-hitch is tightened in the direction that it was intended to be placed, and can also prevent the unintentional tension applied to the wrapping suture limb that causes the half-hitch to "flip." However, caution should be used when tensioning the half-hitches; overtensioning (>40 N) during past-pointing or over-pointing could also potentially "flip" the previous half-hitch that has already been tightened and cause potential knot failure. PMID:27462541

  4. Alternative Approaches for Incentivizing the Frequency Responsive Reserve Ancillary Service

    Energy Technology Data Exchange (ETDEWEB)

    Ela, E.; Milligan, M.; Kirby, B.; Tuohy, A.; Brooks, D.

    2012-03-01

    Frequency responsive reserve is the autonomous response of generators and demand response to deviations of system frequency, usually as a result of the instantaneous outage of a large supplier. Frequency responsive reserve arrests the frequency decline resulting in the stabilization of system frequency, and avoids the triggering of under-frequency load-shedding or the reaching of unstable frequencies that could ultimately lead to system blackouts. It is a crucial service required to maintain a reliable and secure power system. Regions with restructured electricity markets have historically had a lack of incentives for frequency responsive reserve because generators inherently provided the response and on large interconnected systems, more than sufficient response has been available. This may not be the case in future systems due to new technologies and declining response. This paper discusses the issues that can occur without proper incentives and even disincentives, and proposes alternatives to introduce incentives for resources to provide frequency responsive reserve to ensure an efficient and reliable power system.

  5. Alternate approaches to future electron-positron linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Loew, G.A. [Stanford Univ., CA (United States). Stanford Linear Accelerator Center

    1998-07-01

    The purpose of this article is two-fold: to review the current international status of various design approaches to the next generation of e{sup +}e{sup {minus}} linear colliders, and on the occasion of his 80th birthday, to celebrate Richard B. Neal`s many contributions to the field of linear accelerators. As it turns out, combining these two tasks is a rather natural enterprise because of Neal`s long professional involvement and insight into many of the problems and options which the international e{sup +}e{sup {minus}} linear collider community is currently studying to achieve a practical design for a future machine.

  6. An Alternative Approach to the Teaching of Systematic Transition Metal Chemistry.

    Science.gov (United States)

    Hathaway, Brian

    1979-01-01

    Presents an alternative approach to teaching Systematic Transition Metal Chemistry with the transition metal chemistry skeleton features of interest. The "skeleton" is intended as a guide to predicting the chemistry of a selected compound. (Author/SA)

  7. The Mind-Body Connection - Complementary and Alternative Approaches to Health

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues The Mind-Body Connection Complementary and Alternative Approaches to Health ... To Find Out More At medlineplus.gov , type "mind-body" or "emotions" into the Search box. There ...

  8. An Intelligent Alternative Approach to the efficient Network Management

    Directory of Open Access Journals (Sweden)

    MARTÍN, A.

    2012-12-01

    Full Text Available Due to the increasing complexity and heterogeneity of networks and services, many efforts have been made to develop intelligent techniques for management. Network intelligent management is a key technology for operating large heterogeneous data transmission networks. This paper presents a proposal for an architecture that integrates management object specifications and the knowledge of expert systems. We present a new approach named Integrated Expert Management, for learning objects based on expert management rules and describe the design and implementation of an integrated intelligent management platform based on OSI and Internet management models. The main contributions of our approach is the integration of both expert system and managed models, so we can make use of them to construct more flexible intelligent management network. The prototype SONAP (Software for Network Assistant and Performance is accuracy-aware since it can control and manage a network. We have tested our system on real data to the fault diagnostic in a telecommunication system of a power utility. The results validate the model and show a significant improvement with respect to the number of rules and the error rate in others systems.

  9. AN ALTERNATIVE APPROACH TO GLOBAL ROBUST OUTPUT REGULATION OF OUTPUT FEEDBACK SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Jie HUANG

    2007-01-01

    The global robust output regulation problem of the output feedback systems has been extensively studied under various assumptions of the complexity and uncertainty. All these approaches boil down to a stabilization problem of a so-called augmented extended system. This paper will describe an alternative approach which converts the original problem into a stabilization problem of a so-called extended augmented system. As the extended augmented system is somewhat simpler than the augmented extended system, this alternative approach is also simpler than the first approach.

  10. Alternative Models of Service, Centralized Machine Operations. Phase II Report. Volume II.

    Science.gov (United States)

    Technology Management Corp., Alexandria, VA.

    A study was conducted to determine if the centralization of playback machine operations for the national free library program would be feasible, economical, and desirable. An alternative model of playback machine services was constructed and compared with existing network operations considering both cost and service. The alternative model was…

  11. An alternative approach to tritium-in-water monitoring

    CERN Document Server

    Kherani, N P

    2002-01-01

    A paradigm shift in the approach to tritium-in-water monitoring is considered and its viability demonstrated through a series of proof-of-principle experiments. The fundamental difference in the proposed detection system consists of changing the state of the tritiated water from the liquid phase to the gas phase and subsequently using any one of a variety of detection methods to detect tritium in the water vapour. Proof-of-principle experiments using an un-optimized heated ionization chamber illustrate the viability of the proposed method. Operation of the experiment as a continuous in-line detection system shows a detection limit of approx 20 mu Ci/l, a detection time constant of 10 s, and simplicity and effectiveness of the overall system. It is projected that an optimized heated ionization chamber system using state-of-the-art current measuring circuitry, could yield a detection limit of approx 0.2 mu Ci/l. Furthermore, application of a more sensitive detection system (for example, the gas electron multipl...

  12. Peatland geoengineering: an alternative approach to terrestrial carbon sequestration.

    Science.gov (United States)

    Freeman, Christopher; Fenner, Nathalie; Shirsat, Anil H

    2012-09-13

    Terrestrial and oceanic ecosystems contribute almost equally to the sequestration of ca 50 per cent of anthropogenic CO(2) emissions, and already play a role in minimizing our impact on Earth's climate. On land, the majority of the sequestered carbon enters soil carbon stores. Almost one-third of that soil carbon can be found in peatlands, an area covering just 2-3% of the Earth's landmass. Peatlands are thus well established as powerful agents of carbon capture and storage; the preservation of archaeological artefacts, such as ancient bog bodies, further attest to their exceptional preservative properties. Peatlands have higher carbon storage densities per unit ecosystem area than either the oceans or dry terrestrial systems. However, despite attempts over a number of years at enhancing carbon capture in the oceans or in land-based afforestation schemes, no attempt has yet been made to optimize peatland carbon storage capacity or even to harness peatlands to store externally captured carbon. Recent studies suggest that peatland carbon sequestration is due to the inhibitory effects of phenolic compounds that create an 'enzymic latch' on decomposition. Here, we propose to harness that mechanism in a series of peatland geoengineering strategies whereby molecular, biogeochemical, agronomical and afforestation approaches increase carbon capture and long-term sequestration in peat-forming terrestrial ecosystems.

  13. Setting Win Limits: An Alternative Approach to "Responsible Gambling"?

    Science.gov (United States)

    Walker, Douglas M; Litvin, Stephen W; Sobel, Russell S; St-Pierre, Renée A

    2015-09-01

    Social scientists, governments, and the casino industry have all emphasized the need for casino patrons to "gamble responsibly." Strategies for responsible gambling include self-imposed time limits and loss limits on gambling. Such strategies help prevent people from losing more than they can afford and may help prevent excessive gambling behavior. Yet, loss limits also make it more likely that casino patrons leave when they are losing. Oddly, the literature makes no mention of "win limits" as a potential approach to responsible gambling. A win limit would be similar to a loss limit, except the gambler would leave the casino upon reaching a pre-set level of winnings. We anticipate that a self-imposed win limit will reduce the gambler's average loss and, by default, also reduce the casino's profit. We test the effect of a self-imposed win limit by running slot machine simulations in which the treatment group of players has self-imposed and self-enforced win and loss limits, while the control group has a self-imposed loss limit or no limit. We find that the results conform to our expectations: the win limit results in improved player performance and reduced casino profits. Additional research is needed, however, to determine whether win limits could be a useful component of a responsible gambling strategy. PMID:24567070

  14. An Alternative Educational Approach for an Inorganic Chemistry Laboratory Course in Industrial and Chemical Engineering

    Science.gov (United States)

    Garces, Andres; Sanchez-Barba, Luis Fernando

    2011-01-01

    We describe an alternative educational approach for an inorganic chemistry laboratory module named "Experimentation in Chemistry", which is included in Industrial Engineering and Chemical Engineering courses. The main aims of the new approach were to reduce the high levels of failure and dropout on the module and to make the content match the…

  15. Then and Now: Approaches to Understanding Children's Literature in Two Volumes

    Directory of Open Access Journals (Sweden)

    Baker M Bani-Khair

    2016-06-01

    Full Text Available This research paper investigates two main volumes taken from Children's Literature Association Quarterly; the earlier one is Vol. 11 published in 1986, and the other one, a more recent one, Vol. 32 published in 2007, as to understand the differences and similarities regarding the approaches used in the articles to understand Children's Literature in terms of its multifarious aspects such us, literary genres, styles, themes, and methodologies. Such kind of comparison yielded that those differences between those two volumes cover new thematic suggestions, new treatment and projection of characters, and strict scholarship which make the newer volume different in terms of approaches from the earlier one. The research also concluded that modern analytical perspectives are probably the most obvious transformations and changes in the second volume.Keywords: Volume, approach, childhood, construction, scholarship, transformation, modernism, historicism, analysis

  16. Space station crew safety alternatives study. Volume 3: Safety impact of human factors

    Science.gov (United States)

    Rockoff, L. A.; Raasch, R. F.; Peercy, R. L., Jr.

    1985-01-01

    The first 15 years of accumulated space station concepts for Initial Operational Capability (IOC) during the early 1990's was considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris. Of particular interest here is volume three (of five volumes) pertaining to the safety impact of human factors.

  17. Final cost reduction study for the Geysers Recharge Alternative. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The purpose of this study is to determine whether or not cost reduction opportunities exist for the Geysers Recharge Alternative as defined in the Santa Rosa Subregional Long-Term Wastewater Project EIR/EIS. The City of Santa Rosa has been directed to have a plan for reclaimed water disposal in place by 1999 which will meet future capacity needs under all weather conditions. A Draft EIR/EIS released in July 1996 and a Final EIR certified in June 1997 examine four primary alternatives plus the No Action Alternative. Two of the primary alternatives involve agricultural irrigation with reclaimed water, either in western or southern Sonoma County. Another involves increased discharge of reclaimed water into the Russian River. The fourth involves using reclaimed water to replenish the geothermal reservoir at the Geysers. The addition of this water source would enable the Geysers operators to produce more steam from the geothermal area and thereby prolong the life and economic production level of the steamfield and the geothermal power plants supplied by the steamfield. This study provides additional refined cost estimates for new scenarios which utilize an alternative pipeline alignment and a range of reclaimed water flows, which deliver less water to the Geysers than proposed in the EIR/EIS (by distributing flow to other project components). Also, electrical power rates were revised to reflect the recent changes in costs associated with deregulation of the power industry. In addition, this report provides information on sources of potential public and private funding available and future environmental documentation required if the cost reduction scenarios were to be selected by the City as part of their preferred alternative.

  18. Ion Recognition Approach to Volume Reduction of Alkaline Tank Waste by Separation and Recycle of Sodium Hydroxide and Sodium Nitrate

    International Nuclear Information System (INIS)

    This research was intended to provide the scientific foundation upon which the feasibility of liquid-liquid extraction chemistry for bulk reduction of the volume of high-activity tank waste can be evaluated. Primary focus has been on sodium hydroxide separation, with potential Hanford application. Value in sodium hydroxide separation can potentially be found in alternative flowsheets for treatment and disposal of low-activity salt waste. Additional value can be expected in recycle of sodium hydroxide for use in waste retrieval and sludge washing, whereupon additions of fresh sodium hydroxide to the waste can be avoided. Potential savings are large both because of the huge cost of vitrification of the low-activity waste stream and because volume reduction of high-activity wastes could obviate construction of costly new tanks. Toward these ends, the conceptual development begun in the original proposal was extended with the formulation of eight fundamental approaches that could be undertaken for extraction of sodium hydroxide

  19. Complementary and alternative approaches used by parents of children with epilepsy on epilepsy management.

    Science.gov (United States)

    Işler, Ayşegül; Turan, Fatma Dilek; Gözüm, Sebahat; Oncel, Selma

    2014-03-01

    The aim of this study was to determine the complementary and alternative approaches used by parents of children with epilepsy on epilepsy management. This descriptive study included a total of 304 parents of children with epilepsy aged between 0 and 18years evaluated at the Pediatric Neurology Clinic of Akdeniz University Hospital in Turkey between January and May 2013. Data were collected by using a questionnaire developed by the researchers. It was determined that all the parents use complementary and alternative approaches for their children with epilepsy, and the most common approaches are praying (99.3%); keeping their children away from the effects of smoking (79.8%); feeding their children walnuts (79.6%), butter (59.2%), and bone marrow (58.6%); providing their children with good quality sleep (58.6%); and enabling their children to play games (51%). The approaches commonly applied during seizures include praying (96.2%), comforting their children in their arms and showing affection (55.6%), waiting for seizures to finish at home (45.7%), and laying children on their side (41.1%). Of parents, 98% stated that alternative approaches enable them to control their child's seizures, 100% said that alternative approaches have no adverse effect, and 98.4% stated that they will continue to use these approaches. The children's approaches to cope with epilepsy included looking after pets (72.7%), listening to music (70.1%), watching television (64.5%), playing games (55.3%), praying (51%), and spending time with friends (48.7%). Most of the approaches used by parents and children with epilepsy for the management of illness are determined to consist of complementary approaches that may contribute to management of epilepsy. Knowing the approaches of parents and children with epilepsy that could adversely affect disease management is important for educating parents and children to avoid these potentially harmful interventions. PMID:24462737

  20. Data summary of municipal solid waste management alternatives. Volume 11, Alphabetically indexed bibliography

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix contains the alphabetically indexed bibliography for the complete group of reports on municipal waste management alternatives. The references are listed for each of the following topics: mass burn technologies, RDF technologies, fluidized-bed combustion, pyrolysis and gasification of MSW, materials recovery- recycling technologies, sanitary landfills, composting, and anaerobic digestion of MSW.

  1. Data summary of municipal solid waste management alternatives. Volume 4, Appendix B: RDF technologies

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix contains background information, technical descriptions, economic data, mass and energy balances, and information on environmental releases for the refuse derived fuels (RDF) option in municipal solid waste management alternatives. Demonstration programs at St. Louis, Missouri; Franklin, Ohio; and Delaware are discussed. Information on pellet production and cofiring with coal is also presented.

  2. Data summary of municipal solid waste management alternatives. Volume 12, Numerically indexed bibliography

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix contains the numerically indexed bibliography for the complete group of reports on municipal solid waste management alternatives. The list references information on the following topics: mass burn technologies, RDF technologies, fluidized bed combustion, pyrolysis and gasification of MSW, materials recovery- recycling technologies, sanitary landfills, composting and anaerobic digestion of MSW.

  3. Draft Programmatic Environmental Impact Statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 2: Appendices

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky; Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. The preferred alternative for the long-term management of depleted UF6 is to use the entire inventory of material. This volume contains the appendices to volume I

  4. Generalized Navier Boundary Condition for a Volume Of Fluid approach using a Finite-Volume method

    CERN Document Server

    Boelens, A M P

    2016-01-01

    In this work, an analytical Volume Of Fluid (VOF) implementation of the Generalized Navier Boundary Condition is presented based on the Brackbill surface tension model. The model is validated by simulations of droplets on a smooth surface in a planar geometry. Looking at the static behavior of the droplets, it is found that there is a good match between the droplet shape resolved in the simulations and the theoretically predicted shape for various values of the Young's angle. Evaluating the spreading of a droplet on a completely wetting surface, the Voinov-Tanner-Cox law ($\\theta \\propto \\text{Ca}^{1/3}$) can be observed. At later times scaling follows $r \\propto t^{1/2}$, suggesting spreading is limited by inertia. These observations are made without any fitting parameters except the slip length.

  5. An alternative approach for teacher education framed by a collaborative partnership setting

    DEFF Research Database (Denmark)

    Pontoppidan, Birgitte Schou

    2010-01-01

    The study presents an alternative didactical approach to teacher education linking practice and theory through a collaborative partnership setting. Using a ―small scale teaching design in which students alternate between schools and college it was possible to show someevidence that, by following...... this approach, first year student teachers in a science & technology class developed teacher knowledge (as aspects of PCK). The study identifies an example using Co-Re and PaPeR as a Resource Folio to show where evidence of developing teacher knowledge is seen. This didactical approach turns the traditional...... teacher education on its head and begins with a focus on practice so students alternate between school–based and college–based teaching in a cyclical fashion, and are encouraged to link theory with practice. This kind of college teaching demands a new teacher educational paradigm for which collaboration...

  6. AN ALTERNATIVE APPROACH FOR TEACHER EDUCATION COURSES FRAMED BY A COLLABORATE PARTNERSHIP

    DEFF Research Database (Denmark)

    Pontoppidan, Birgitte

    2010-01-01

    The study presents an alternative didactical approach to teacher education linking practice and theory through a collaborative partnership setting. Using a “small scale” teaching design in which students alternate between schools and college it was possible to show some evidence that, by following...... this approach, first year student teachers in a science & technology class developed teacher knowledge (as aspects of PCK). The study identifies an example using Co-Re and PaPeR as a Resource Folio to show where evidence of developing teacher knowledge is seen. This didactical approach turns the traditional...... teacher education on its head and begins with a focus on practice so students alternate between school–based and college–based teaching in a cyclical fashion, and are encouraged to link theory with practice. This kind of college teaching demands a new teacher educational paradigm for which collaboration...

  7. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    International Nuclear Information System (INIS)

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations

  8. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    International Nuclear Information System (INIS)

    This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

  9. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest.

  10. K Basin spent fuel sludge treatment alternatives study. Volume 2, Technical options

    International Nuclear Information System (INIS)

    Approximately 2100 metric tons of irradiated N Reactor fuel are stored in the KE and KW Basins at the Hanford Site, Richland, Washington. Corrosion of the fuel has led to the formation of sludges, both within the storage canisters and on the basin floors. Concern about the degraded condition of the fuel and the potential for leakage from the basins in proximity to the Columbia River has resulted in DOE's commitment in the Tri-Party Agreement (TPA) to Milestone M-34-00-T08 to remove the fuel and sludges by a December 2002 target date. To support the planning for this expedited removal action, the implications of sludge management under various scenarios are examined. This report, Volume 2 of two volumes, describes the technical options for managing the sludges, including schedule and cost impacts, and assesses strategies for establishing a preferred path

  11. Assessment of management alternatives for LWR wastes. Volume 1. Main achievements of the joint study

    International Nuclear Information System (INIS)

    This report deals with the main achievements of a joint theoretical study aimed at evaluating a selection of management routes for LWR wastes, relying to a certain extent on national practices in this particular area, on the basis of economical and radiological criteria. All individual intermediate steps entering a management route, from radioactive-wastes production up to their disposal in near-surface sites or in a deep repository, have been identified, described and cost-evaluated throughout the study. The radiological impact assessment comprises estimates of both individual and collective doses resulting from normal discharges of radioactive effluents and from disposal of radioactive waste products in near-surfaces sites. All specific data concerning the description of the different management routes considered as well as the methodology applied to evaluate cost and radiological impact are detailed in the subsequent volumes of the series (Volumes 2 to 8)

  12. Spreadsheet Assurance by "Control Around" is a Viable Alternative to the Traditional Approach

    CERN Document Server

    Ettema, Harmen; de Swart, Jacques

    2008-01-01

    The traditional approach to spreadsheet auditing generally consists of auditing every distinct formula within a spreadsheet. Although tools are developed to support auditors during this process, the approach is still very time consuming and therefore relatively expensive. As an alternative to the traditional "control through" approach, this paper discusses a "control around" approach. Within the proposed approach not all distinct formulas are audited separately, but the relationship between input data and output data of a spreadsheet is audited through comparison with a shadow model developed in a modelling language. Differences between the two models then imply possible errors in the spreadsheet. This paper describes relevant issues regarding the "control around" approach and the circumstances in which this approach is preferred above a traditional spreadsheet audit approach.

  13. Alternative scenarios for Federal transportation policy. Volume I. Summary. First year final report

    Energy Technology Data Exchange (ETDEWEB)

    Friedlaender, A.; Simpson, R.

    1977-01-01

    A summary is given of research evaluating the economic effects of existing and prospective federal policies governing intercity and international freight and passenger transportation enterprises in the economy of the United States. The analysis encompasses all modes of transportation, including rail, motor, water, air and intermodal coordinative institutions, and focuses upon the impact of alternative regulatory policies. However, other federal policies including subsidy, taxation, procurement, government ownership and investment, special programs for particular transportation industry problems and impacts of general national policies on transportation will be included when relevant. Economic evaluation includes the study of efficient resource allocation and distributional effects of alternative policies together with consideration of both partial and general equilibrium effects. The research is interdisciplinary in scope, drawing upon engineering, economics, statistics, law and administration.

  14. Alternative-fuel production facility for City of Huntsville, Alabama. Volume I. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    1982-10-01

    The feasibility of a Municipal Solid Waste (MSW)-to-energy project in the Huntsville area was invetigated and found to be an environmentally attractive and cost effective method of MSW disposal. Of nine likely alternatives, that were developed for detailed evaluation and analysis. Alternative 1M surfaced as best for the City. It is described as follows: a MSW-To-Energy Plant, consisting of two 300 TPD Mass Burning Waterwall Furnace/Boiler Systems at Lowe Industrial Park to provide low pressure steam to industries in the park. A MSW Transfer Station at the existing landfill and MSW as well as residue transport rolling stock equipment is included to facilitate movement of the waste materials between the two locations that are some twelve miles apart.

  15. Joint 3D inversion of gravity and magnetic data with geological constraints - an alternative approach

    Science.gov (United States)

    Prutkin, Ilya; Vajda, Peter; Jentzsch, Gerhard

    2016-04-01

    Quite a popular approach now by interpretation of gravity data is a linear one - an attempt is made to find a density distribution d(x,y,z) below the Earth's surface. This approach has clear disadvantages. First, we face the problem of dimensionality: one looks for 3D function based on 2D data set (measurements on the Earth's surface), the degree of non-uniqueness is extremely high, and no regularization can save the situation. The number of unknowns is many times higher than the number of observations; otherwise, we obtain a very rough model of the lower half-space. Second, the linear approach is not reasonable from the geological point of view. It implies that density varies from one point to another. Usually, we assume big volumes with nearly homogeneous density - layers, blocks, intrusions. It looks more understandable, to search for geometry of density interfaces: 3D topography of contact surfaces and shapes of restricted bodies (intrusions). Third, in the framework of the linear approach even for a synthetic field of two separate objects we obtain clouds of points with slightly increased density. It is hardly ever possible, to isolate objects, particularly when one of them is located above another one. We suggest an alternative approach for the linear one. Our approach has been successfully applied for several case histories including a local gravity anomaly Kolarovo and a bigger area of the Thuringian Basin, where both gravity and magnetic data are inverted. First, we separate sources into deep, intermediate and shallow ones, using subsequent upward and downward continuation. All components are inverted separately. We address a problem which we name the problem of low frequencies: deep objects generate long wavelengths, but the converse implication is not necessarily true. For instance, the effect of the basin structure contributes substantially into low frequencies, though it is caused by shallow sources. However, our numerical experiments with intermediate

  16. A novel approach to predict the excess volume of hydrocarbon mixtures

    NARCIS (Netherlands)

    Finkers, H. J.; Bosma, J. C.; Broekhuis, A. A.

    2011-01-01

    This paper explores whether principles obtained for the packing of solid macroscopic particles can be applied to the study of excess volumes of liquid mixtures. The approach is applied to mixtures of 'pure' hydrocarbons, i.e. containing only C- and H-atoms. In this new approach a set of equations wa

  17. A Half-Flipped Classroom or an Alternative Approach?: Primary Sources and Blended Learning

    Science.gov (United States)

    Westermann, Edward B.

    2014-01-01

    This paper examines an alternate approach to the "flipped" classroom paradigm for an upper level history class using a blended on-line and in-class format. The concept of the flipped classroom has received increasing emphasis based on its potential to create a student-centered learning environment that incorporates practical instruction…

  18. Communicative Approach: An Alternative Method Used in Improving Students' Academic Reading Achievement

    Science.gov (United States)

    Irmawati, Noer Doddy

    2012-01-01

    Academic reading is a difficult subject to be mastered. It is needed because most of books or references are written in English. The emphasis is on academic reading which becomes a compulsory subject that must be taught and understood in Faculty of Letters UAD Yogyakarta. Communicative approach is used and applied as an alternative method in the…

  19. Point patterns occurring on complex structures in space and space-time: An alternative network approach

    CERN Document Server

    Eckardt, Matthias

    2016-01-01

    This paper presents an alternative approach of analyzing possibly multitype point patterns in space and space-time that occur on network structures, and introduces several different graph-related intensity measures. The proposed formalism allows to control for processes on undirected, directional as well as partially directed network structures and is not restricted to linearity or circularity.

  20. Hanford Spent Nuclear Fuel Project: Recommended path forward. Volume 2: Alternatives and path forward evaluation

    International Nuclear Information System (INIS)

    The Hanford Spent Nuclear Fuel Project has completed an evaluation of four alternatives for expediting the removal of spent nuclear fuel from the K Basins and stabilizing and placing the fuel into interim storage. Four alternatives were compared: (1) Containerizing fuel in the K Basins, transporting fuel to a facility for stabilization, and interim storage of stabilized fuel in a dry storage facility (DSF); (2) Containerizing fuel in the K Basins, transporting fuel to a wet temporary staging facility, moving fuel to a facility for stabilization, and transporting stabilized fuel to an interim DSF; (3) Containerizing fuel in the K Basins in multi-canister overpacks, transporting fuel directly to a stabilization facility for passivation in the overpack, and interim storage of stabilized fuel in a DSF; (4) Packaging fuel for transport overseas and shipping fuel to a foreign reprocessing facility for reprocessing with eventual return of U, Pu and vitrified high level waste. The comparative evaluation consisted of a multi-attribute utility decision analysis, a public, worker and environmental health risk assessment, and a programmatic risk evaluation. The evaluation concluded that the best Path Forward combines the following concepts: Removal of K Basin fuel and sludge is uncoupled from the operation of a stabilization facility; A storage capability is provided to act as a lag storage or staging operation for overpack fuel containers as they are removed from the K Basins; Metal fuel drying and passivation should be maintained as the fuel stabilization process with the option of further refinements as more information becomes available; and The near term NEPA strategy should focus on expeditious removal of fuel and sludge from K Basins and placing overpacked fuel in temporary storage

  1. Alternative fuels for vehicles fleet demonstration program final report. Volume 1: Summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The Alternative Fuels for Vehicles Fleet Demonstration Program (AFV-FDP) was a multiyear effort to collect technical data for use in determining the costs and benefits of alternative-fuel vehicles in typical applications in New York State. During 3 years of collecting data, 7.3 million miles of driving were accumulated, 1,003 chassis-dynamometer emissions tests were performed, 862,000 gallons of conventional fuel were saved, and unique information was developed about garage safety recommendations, vehicle performance, and other topics. Findings are organized by vehicle and fuel type. For light-duty compressed natural gas (CNG) vehicles, technology has evolved rapidly and closed-loop, electronically-controlled fuel systems provide performance and emissions advantages over open-loop, mechanical systems. The best CNG technology produces consistently low tailpipe emissions versus gasoline, and can eliminate evaporative emissions. Reduced driving range remains the largest physical drawback. Fuel cost is low ($/Btu) but capital costs are high, indicating that economics are best with vehicles that are used intensively. Propane produces impacts similar to CNG and is less expensive to implement, but fuel cost is higher than gasoline and safety codes limit use in urban areas. Light-duty methanol/ethanol vehicles provide performance and emissions benefits over gasoline with little impact on capital costs, but fuel costs are high. Heavy-duty CNG engines are evolving rapidly and provide large reductions in emissions versus diesel. Capital costs are high for CNG buses and fuel efficiency is reduced, but the fuel is less expensive and overall operating costs are about equal to those of diesel buses. Methanol buses provide performance and emissions benefits versus diesel, but fuel costs are high. Other emerging technologies were also evaluated, including electric vehicles, hybrid-electric vehicles, and fuel cells.

  2. Typological Approaches to Violence in Couples: A Critique and Alternative Conceptual Approach

    OpenAIRE

    Capaldi, Deborah M.; Kim, Hyoun K.

    2006-01-01

    Typological approaches have become highly influential in research on violence in couples, and yet issues related to such approaches have not been well addressed. We review the utility of batterer typologies, both for clinical applications and for understanding violence in couples. The principal types of batterer typologies are discussed, along with a number of issues that might limit their utility for explaining the etiology and developmental course of partner violence in couples. We propose ...

  3. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    International Nuclear Information System (INIS)

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations. While any final assessment of such measures and alternatives would have to examine the circumstances particular to each nation, it is hoped that the more generic assessments conducted here will be useful in suggesting guidelines for developing an improved nonproliferation regime which also helps to meet nuclear-energy needs. One chapter outlines the existing nonproliferation regime, including the Treaty for the Non-Proliferation of Nuclear Weapons (NPT), International Atomic Energy Agency (IAEA) safeguards, bilateral and multilateral requirements for agreements of cooperation and transfers of technology, and existing provisons for sanctions for violation of nonproliferation commitments. The chapter then proceeds to an assessment of various alternatives for providing assurance of fuel supply in light of this current regime. Another chapter examines a set of technical and institutional measures and alternatives for various components of once-through and closed fuel cycles. The components of the once-through fuel cycle assessed are enrichment services and spent-fuel management; the components of closed fuel cycles assessed are reprocessing and plutonium management and fast-breeder reactor (FBR) deployment

  4. Optical approach for the efficient data volume handling in experimentally encrypted data

    International Nuclear Information System (INIS)

    Experimental optical procedures generate a tremendous amount of data, which must be then processed for any practical application. We present a new optical approach in terms of the data volume for the efficient handling of multiple data obtained from an experimental cryptosystem. In order to achieve this goal, we use the combination of optical filtering and optical scaling of the experimentally registered data. The intention is to reduce by optical means the amount of data to be managed. We define a so called ‘efficiency factor’ to describe the effectiveness of the approach. We find that volume reduction depends on this factor and the number of objects to be processed. We achieved substantial data volume reductions up to 94.24%. We introduce the basic concepts as well as experimental results that support both the feasibility and the applicability of our approach. (paper)

  5. Optical approach for the efficient data volume handling in experimentally encrypted data

    Science.gov (United States)

    Trejos, Sorayda; Fredy Barrera, John; Velez, Alejandro; Tebaldi, Myrian; Torroba, Roberto

    2016-06-01

    Experimental optical procedures generate a tremendous amount of data, which must be then processed for any practical application. We present a new optical approach in terms of the data volume for the efficient handling of multiple data obtained from an experimental cryptosystem. In order to achieve this goal, we use the combination of optical filtering and optical scaling of the experimentally registered data. The intention is to reduce by optical means the amount of data to be managed. We define a so called ‘efficiency factor’ to describe the effectiveness of the approach. We find that volume reduction depends on this factor and the number of objects to be processed. We achieved substantial data volume reductions up to 94.24%. We introduce the basic concepts as well as experimental results that support both the feasibility and the applicability of our approach.

  6. The Design of Treatment Wetlands in the United Kingdom: Successes, Failures, and Alternative Approaches

    Institute of Scientific and Technical Information of China (English)

    SUN Guangzhi; ZHANG Guangxin

    2008-01-01

    Constructed wetland was first introduced into the United Kingdom in the middle of 1980s, following a visit by a group of scientist to Western Germany. In the past 2 decades, the applications of constructed wetlands in this country have expanded substantially, due to the demand for green technologies and rising cost of fossil fuel energies. This paper reported a statistical investigation of the performances of 78 horizontal flow wetlands, representatives of such system in the United Kingdom. Alternative design equations, based on organic matter removal efficiency, have been developed from Monod kinetics, and the accuracy and reliability of current and alternative design approaches have been examined.

  7. Alternative strategies to reduce cost and waste volume in HEPA filtration using metallic filter media - 59348

    International Nuclear Information System (INIS)

    Document available in abstract form only. Full text of publication follows: The disposal costs of contaminated HEPA and THE filter elements have been proved to be disproportionately high compared with the cost of the elements themselves. Work published elsewhere (Moore, et el 1992; Bergman et al 1997) suggests that the cost of use of traditional, panel type, glass fibre HEPA filtration trains to the DOE was, during that period, $29.5 million, based on a five year life cycle, and including installation, testing, removal and disposal life cycle costs being based on estimates dating from 1987-1990. Within that cost estimate, $300 was the value given to the filter and $4, 450 was given to the peripheral activity. Clearly, if the $4, 450 component could be reduced, tremendous saving could ensue, in addition to the reduction of the legacy burden of waste volume. This issue exists for operators in both the US and in Europe. If HEPA filters could be cleaned to a condition where they could either be re-used or decontaminated to the extent that they could be stored as a lower cost wasteform or if HEPA/THE filter elements were available without any organic content likely to give rise to flammable or explosive decomposition gases during long term storage this would also reduce the costs and monitoring necessary in storage. (author)

  8. Alternative Endpoints and Approaches for the Remediation of Contaminated Groundwater at Complex Sites - 13426

    International Nuclear Information System (INIS)

    The goal of United States (U.S.) Department of Energy's (DOE)'s environmental remediation programs is to restore groundwater to beneficial use, similar to many other Federal and state environmental cleanup programs. Based on past experience, groundwater remediation to pre-contamination conditions (i.e., drinking water standards or non-detectable concentrations) can be successfully achieved at many sites. At a subset of the most complex sites, however, complete restoration is not likely achievable within the next 50 to 100 years using today's technology. This presentation describes several approaches used at complex sites in the face of these technical challenges. Many complex sites adopted a long-term management approach, whereby contamination was contained within a specified area using active or passive remediation techniques. Consistent with the requirements of their respective environmental cleanup programs, several complex sites selected land use restrictions and used risk management approaches to accordingly adopt alternative cleanup goals (alternative endpoints). Several sites used long-term management designations and approaches in conjunction with the alternative endpoints. Examples include various state designations for groundwater management zones, technical impracticability (TI) waivers or greater risk waivers at Superfund sites, and the use of Monitored Natural Attenuation (MNA) or other passive long-term management approaches over long time frames. This presentation will focus on findings, statistics, and case studies from a recently-completed report for the Department of Defense's Environmental Security Technology Certification Program (ESTCP) (Project ER-0832) on alternative endpoints and approaches for groundwater remediation at complex sites under a variety of Federal and state cleanup programs. The primary objective of the project was to provide environmental managers and regulators with tools, metrics, and information needed to evaluate

  9. Alternative method for determining the original drop volume of bloodstains on knit fabrics.

    Science.gov (United States)

    Li, Jingyao; Li, Xingyu; Michielsen, Stephen

    2016-06-01

    Bloodstains are often observed at violent crime scenes and on the skin and clothing of persons involved. The diameters of the blood drops that created these stains are related to the force or energy that caused these drops to become airborne. This has resulted in several attempts to determine the diameter of the original drops, beginning with the methods reported in the pioneering work of Henry Lee [6]. However, his methods destroyed the bloodstain during the measurement. Other methods described in the literature cannot be applied to bloodstains on textiles. A new, rapid, reliable, non-destructive method for determining the diameter of the original drop of blood that results in a stain has been developed for bloodstains on cotton single jersey knit (tee-shirt) fabrics, which is one of the most common fabrics analyzed for BPA both at crime scenes and in forensic laboratories. In this method, a drop of known volume of an appropriate artificial blood substitute is applied to a region similar to the stained region but in an area away from any stains/areas of interest. The areas of the original stain and the artificial blood substitute stain are determined, from which the original drop diameter can be calculated. Errors in the drop diameters, the Reynolds numbers and the Weber numbers resulting from this procedure are less than approximately 6%. This procedure has only been verified on cotton single jersey knit fabrics with 30μL≤drop volume≤80μL. It should not be applied to other materials. PMID:27131219

  10. Data summary of municipal solid waste management alternatives. Volume 3, Appendix A: Mass burn technologies

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    This appendix on Mass Burn Technologies is the first in a series designed to identify, describe and assess the suitability of several currently or potentially available generic technologies for the management of municipal solid waste (MSW). These appendices, which cover eight core thermoconversion, bioconversion and recycling technologies, reflect public domain information gathered from many sources. Representative sources include: professional journal articles, conference proceedings, selected municipality solid waste management plans and subscription technology data bases. The information presented is intended to serve as background information that will facilitate the preparation of the technoeconomic and life cycle mass, energy and environmental analyses that are being developed for each of the technologies. Mass burn has been and continues to be the predominant technology in Europe for the management of MSW. In the United States, the majority of the existing waste-to-energy projects utilize this technology and nearly 90 percent of all currently planned facilities have selected mass burn systems. Mass burning generally refers to the direct feeding and combustion of municipal solid waste in a furnace without any significant waste preprocessing. The only materials typically removed from the waste stream prior to combustion are large bulky objects and potentially hazardous or undesirable wastes. The technology has evolved over the last 100 or so years from simple incineration to the most highly developed and commercially proven process available for both reducing the volume of MSW and for recovering energy in the forms of steam and electricity. In general, mass burn plants are considered to operate reliably with high availability.

  11. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VIII. Advanced concepts

    International Nuclear Information System (INIS)

    The goal of the Nonproliferation Alternative Systems Assessment Program has been to provide recommendations for the development and deployment of more proliferation-resistant civilian nuclear-power systems without jeopardizing the development of nuclear energy. In principle, new concepts for nuclear-power systems could be designed so that materials and facilities would be inherently more proliferation-resistant. Such advanced, i.e., less-developed systems, are the subject of this volume. Accordingly, from a number of advanced concepts that were proposed for evaluation, six representative concepts were selected: the fast mixed-spectrum reactor; the denatured molten-salt reactor; the mixed-flow gaseous-core reactor; the linear-accelerator fuel-regenerator reactor; the ternary metal-fueled electronuclear fuel-producer reactor; and the tokamak fusion-fission hybrid reactor

  12. Alaska Regional Energy Resources Planning Project. Phase 2: coal, hydroelectric and energy alternatives. Volume I. Beluga Coal District Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rutledge, G.; Lane, D.; Edblom, G.

    1980-01-01

    This volume deals with the problems and procedures inherent in the development of the Beluga Coal District. Socio-economic implications of the development and management alternatives are discussed. A review of permits and approvals necessary for the initial development of Beluga Coal Field is presented. Major land tenure issues in the Beluga Coal District as well as existing transportation routes and proposed routes and sites are discussed. The various coal technologies which might be employed at Beluga are described. Transportation options and associated costs of transporting coal from the mine site area to a connecting point with a major, longer distance transportation made and of transporting coal both within and outside (exportation) the state are discussed. Some environmental issues involved in the development of the Beluga Coal Field are presented. (DMC)

  13. Ion Recognition Approach to Volume Reduction of Alkaline Tank Waste by Separation and Recycle of Sodium Hydroxide and Sodium Nitrate

    International Nuclear Information System (INIS)

    Disposal of high-level nuclear waste is horrendously expensive, in large part because the actual radioactive matter in the tanks has been diluted over 1000-fold by ordinary inorganic chemicals. Treatment processes themselves can exacerbate the problem by adding further volume to the waste. Waste retrieval and sludge washing, for example, will require copious amounts of sodium hydroxide. If the needed sodium hydroxide could be separated from the waste and recycled, however, the addition of fresh sodium hydroxide could be avoided, ultimately reducing the final waste volume and associated disposal costs. The major objective of this research is to explore new liquid-liquid extraction approaches to the selective separation of sodium hydroxide from alkaline high-level wastes stored in underground tanks at the Hanford and Savannah River sites. Consideration is also given to separating potassium and abundant anions, including nitrate, nitrite, aluminate, and carbonate. Salts of these ions represent possible additional value for recycle, alternative disposal, or even use as commodity chemicals. A comprehensive approach toward understanding the extractive chemistry of these salts is envisioned, involving systems of varying complexity, from use of simple solvents to new bifunctional host molecules for ion-pair recognition. These extractants will ideally require no adjustment of the waste composition and will release the extracted salt into water, thereby consuming no additional chemicals and producing no additional waste volume. The overall goal of this research is to provide a scientific foundation upon which the feasibility of new liquid-liquid extraction chemistry applicable to the bulk reduction of the volume of tank waste can be evaluated

  14. Exploring the use of systems thinking approaches in the management of alternative food networks

    DEFF Research Database (Denmark)

    Tavella, Elena

    This PhD-study takes up two challenges: firstly, to suggest, describe and analyse Systems Thinking approaches, especially Problem Structuring Methods (PSMs), as means to problem solving and enhancing management processes within Alternative Food Networks; secondly, to empirically assess the claim...... and intervenes in selected European Alternative Food Networks. The researcher selects and combines different Systems Thinking approaches, describes and illustrates them with real-world cases and interventions, reflects on the interventions, and qualitatively analyses one problem structuring workshop with (i...... workshop facilitated by an expert and two novices within a local food network in the UK. Drawing on the facilitation roles in Huxham & Cropper (1994), the researcher compares and contrasts how the facilitators behave while managing the workshop, and analyzes the extent to which they behave differently...

  15. An alternative to the standard spatial econometric approaches in hedonic house price models

    DEFF Research Database (Denmark)

    Veie, Kathrine Lausted; Panduro, Toke Emil

    Hedonic models are subject to spatially correlated errors which are a symptom of omitted spatial variables, mis-specification or mismeasurement. Methods have been developed to address this problem through the use of spatial econometrics or spatial fixed effects. However, often spatial correlation...... is modeled without much consideration of the theoretical implications of the chosen model or treated as a nuisance to be dealt with holding little interest of its own. We discuss the limitations of current standard spatial approaches and demonstrate, both empirically and theoretically the generalized...... additive model as an alternative. The generalized additive model is compared with the spatial error model and the fixed effects model. We find the generalized additive model to be a solid alternative to the standard approaches, having less restrictive assumptions about the omitted spatial processes while...

  16. Docility and “through doing” morality: An alternative approach to ethics

    OpenAIRE

    Magnani Lorenzo; Bardone Emanuele; Secchi Davide

    2006-01-01

    In this paper, we aim at presenting the distributed morality approach as it can be described by the docility model of social interactions. The proposition “morality is a matter of social interaction” constitutes our starting point. We aim at pointing out the ways through which individuals create moral alternatives to a given situation. The paper is dedicated to presenting morality as something connected to human cognition. We introduce a “manipulative” way of thinking about morality, and we a...

  17. An alternative to the standard spatial econometric approaches in hedonic house price models

    DEFF Research Database (Denmark)

    von Graevenitz, Kathrine; Panduro, Toke Emil

    2015-01-01

    Omitted, misspecified, or mismeasured spatially varying characteristics are a cause for concern in hedonic house price models. Spatial econometrics or spatial fixed effects have become popular ways of addressing these concerns. We discuss the limitations of standard spatial approaches to hedonic...... modeling and demonstrate the spatial generalized additive model as an alternative. Parameter estimates for several spatially varying regressors are shown to be sensitive to the scale of the fixed effects and bandwidth dimension used to control for omitted variables. This sensitivity reflects...

  18. An Alternative Approach for Determining Photoionization Rate in H2+: Numerical Results

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yu; ZHANG Gui-Zhong; XIANG Wang-Hua; W.T. Hill Ⅲ

    2005-01-01

    @@ We present an alternative approach for determining the photoionization rate of hydrogen molecules under the interaction of intense light, by calculating the spatial overlap integral between the potential function and the time-dependent wavefunction. The suggested method was applied to varying excitation pulse shapes: square envelope and chirped hyperbolic secant envelope. The computed results confirmed that our method was robust and could be extended to general molecular dynamics calculations.

  19. Strategies for laboratory HIV testing: an examination of alternative approaches not requiring Western blot.

    OpenAIRE

    Sato, P. A.; Maskill, W. J.; Tamashiro, H.; Heymann, D L

    1994-01-01

    Advances in laboratory tests for antibodies to human immunodeficiency virus (HIV) have permitted the development of alternative HIV testing strategies that do not require use of the Western blot approach. Three strategies are proposed. In strategy I, sera are tested for HIV antibody using an enzyme-linked immunosorbent assay (ELISA)/rapid/simple (ERS) test; in strategy II, sera reactive in an initial ERS test are retested using a second ERS test; strategy III involves retesting with a third E...

  20. Anterior sagittal anorectoplasty: An alternative to posterior approach in management of congenital vestibular fistula

    OpenAIRE

    Man Mohan Harjai; Navdeep Sethi; Naveen Chandra

    2013-01-01

    Background: Better exposure, possibility of extension if needed and precise placement of the anal canal within the external sphincter complex have made the posterior and anterior sagittal approaches more popular and established for the correction of anovestibular fistula. The mini posterior sagittal anorectoplasty (PSARP) was the procedure of choice for female ARM at our center till date. As an alternative surgical option, we performed anterior sagittal anorectoplasty (ASARP) in 15 cases of a...

  1. An Alternative Dimension Reduction Approach to Supervised Principal Components Analysis in High Dimensional Survival Data

    OpenAIRE

    Elvan AKTURK HAYAT; Mevlut TURE; Sansli SENOL

    2016-01-01

    Objective: This study aims at comparing the performances of supervised principal component analysis (SPCA) which is used for dimension reduction and an alternatively proposed approach of nonlinear principal component analysis using artificial neural networks performed by gene selection with survival tree (survival tree based NLPCA- NN). Material and Methods: Gene expression data set from Rosenwald et al.(2002) pertaining to 240 patients with diffuse large B-cell lymphoma (DLBCL) is used. Whil...

  2. Communicating with parents of children with autism about vaccines and complementary and alternative approaches.

    Science.gov (United States)

    Gupta, Vidya Bhushan

    2010-05-01

    Despite incontrovertible evidence that vaccines do not cause autism, some parents continue to refuse them and many parents of children with autism seek hope in unproven and potentially harmful complementary and alternative (CAM) approaches. This commentary explores the reasons for such behaviors and proposes that pediatricians may support parents in their pursuit of hope in unproven treatments as long as these are not potentially harmful to the child or prohibitively expensive. While respecting parental autonomy and hope the pediatricians should share with parents their concerns about lack of scientific evidence about CAM and potential for harm by some approaches.

  3. Alternative approach for Article 5. Energie Efficiency Directive; Alternatieve aanpak artikel 5. Energy Efficiency Directive

    Energy Technology Data Exchange (ETDEWEB)

    Menkveld, M.; Jablonska, B. [ECN Beleidsstudies, Petten (Netherlands)

    2013-05-15

    Article 5 of the Energy Efficiency Directive (EED) is an annual obligation to renovate 3% of the building stock of central government. After renovation the buildings will meet the minimum energy performance requirements laid down in Article 4 of the EPBD. The Directive gives room to an alternative approach to achieve the same savings. The Ministry of Interior Affairs has asked ECN to assist with this alternative approach. ECN calculated what saving are achieved with the 3% renovation obligation under the directive. Then ECN looked for the possibilities for an alternative approach to achieve the same savings [Dutch] In artikel 5 van de Energie Efficiency Directive (EED) staat een verplichting om jaarlijks 3% van de gebouwvoorraad van de centrale overheid te renoveren. Die 3% van de gebouwvoorraad moet na renovatie voldoen aan de minimum eisen inzake energieprestatie die door het betreffende lidstaat zijn vastgelegd op grond van artikel 4 in de EPBD. De verplichting betreft gebouwen die in bezit en in gebruik zijn van de rijksoverheid met een gebruiksoppervlakte groter dan 500 m{sup 2}, vanaf juli 2015 groter dan 250 m{sup 2}. De gebouwen die eigendom zijn van de Rijksgebouwendienst betreft kantoren van rijksdiensten, gerechtsgebouwen, gebouwen van douane en politie en gevangenissen. Van de gebouwen van Defensie hoeven alleen kantoren en legeringsgebouwen aan de verplichting te voldoen.

  4. Data summary of municipal solid waste management alternatives. Volume 8, Appendix F, Landfills

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    While the preceding appendices have focused on the thermochemical approaches to managing municipal solid waste (MSW), this appendix and those that follow on composting and anaerobic digestion address more of the bioconversion process technologies. Landfilling is the historical baseline MSW management option central to every community`s solid waste management plan. It generally encompasses shredfills, balefills, landfill gas recovery, and landfill mining. While landfilling is virtually universal in use, it continues to undergo intense scrutiny by the public and regulators alike. Most recently, the US Environmental Protection Agency (EPA) issued its final rule on criteria for designing, operating, monitoring, and closing municipal solid waste landfills. While the Federal government has established nationwide standards and will assist the States in planning and developing their own practices, the States and local governments will carry out the actual planning and direct implementation. The States will also be authorized to devise programs to deal with their specific conditions and needs. While the main body of this appendix and corresponding research was originally prepared in July of 1991, references to the new RCRA Subtitle D, Part 258 EPA regulations have been included in this resubmission (908). By virtue of timing, this appendix is, necessarily, a ``transition`` document, combining basic landfill design and operation information as well as reference to new regulatory requirements. Given the speed with which landfill practices are and will be changing, the reader is encouraged to refer to Part 258 for additional details. As States set additional requirements and schedules and owners and operators of MSW landfills seek to comply, additional guidance and technical information, including case studies, will likely become available in the literature.

  5. Data Summary of Municipal Solid Waste Management Alternatives. Volume VIII: Appendix F - Landfills

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-10-01

    While the preceding appendices have focused on the thermochemical approaches to managing municipal solid waste (MSW), this appendix and those that follow on composting and anaerobic digestion address more of the bioconversion process technologies. Landfilling is the historical baseline MSW management option central to every community's solid waste management plan. It generally encompasses shredfills, balefills, landfill gas recovery, and landfill mining. While landfilling is virtually universal in use, it continues to undergo intense scrutiny by the public and regulators alike. Most recently, the US Environmental Protection Agency (EPA) issued its final rule on criteria for designing, operating, monitoring, and closing municipal solid waste landfills. While the Federal government has established nationwide standards and will assist the States in planning and developing their own practices, the States and local governments will carry out the actual planning and direct implementation. The States will also be authorized to devise programs to deal with their specific conditions and needs. While the main body of this appendix and corresponding research was originally prepared in July of 1991, references to the new RCRA Subtitle D, Part 258 EPA regulations have been included in this resubmission (908). By virtue of timing, this appendix is, necessarily, a transition'' document, combining basic landfill design and operation information as well as reference to new regulatory requirements. Given the speed with which landfill practices are and will be changing, the reader is encouraged to refer to Part 258 for additional details. As States set additional requirements and schedules and owners and operators of MSW landfills seek to comply, additional guidance and technical information, including case studies, will likely become available in the literature.

  6. Digital breast tomosynthesis: computerized detection of microcalcifications in reconstructed breast volume using a 3D approach

    Science.gov (United States)

    Chan, Heang-Ping; Sahiner, Berkman; Wei, Jun; Hadjiiski, Lubomir M.; Zhou, Chuan; Helvie, Mark A.

    2010-03-01

    We are developing a computer-aided detection (CAD) system for clustered microcalcifications in digital breast tomosynthesis (DBT). In this preliminary study, we investigated the approach of detecting microcalcifications in the tomosynthesized volume. The DBT volume is first enhanced by 3D multi-scale filtering and analysis of the eigenvalues of Hessian matrices with a calcification response function and signal-to-noise ratio enhancement filtering. Potential signal sites are identified in the enhanced volume and local analysis is performed to further characterize each object. A 3D dynamic clustering procedure is designed to locate potential clusters using hierarchical criteria. We collected a pilot data set of two-view DBT mammograms of 39 breasts containing microcalcification clusters (17 malignant, 22 benign) with IRB approval. A total of 74 clusters were identified by an experienced radiologist in the 78 DBT views. Our prototype CAD system achieved view-based sensitivity of 90% and 80% at an average FP rate of 7.3 and 2.0 clusters per volume, respectively. At the same levels of case-based sensitivity, the FP rates were 3.6 and 1.3 clusters per volume, respectively. For the subset of malignant clusters, the view-based detection sensitivity was 94% and 82% at an average FP rate of 6.0 and 1.5 FP clusters per volume, respectively. At the same levels of case-based sensitivity, the FP rates were 1.2 and 0.9 clusters per volume, respectively. This study demonstrated that computerized microcalcification detection in 3D is a promising approach to the development of a CAD system for DBT. Study is underway to further improve the computer-vision methods and to optimize the processing parameters using a larger data set.

  7. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    International Nuclear Information System (INIS)

    This volume of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power - generating capability and one without

  8. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This volume of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power - generating capability and one without.

  9. A risk management approach to double-shell tank waste volume versus storage capacity

    Energy Technology Data Exchange (ETDEWEB)

    Coles, G.A. [Westinghouse Hanford Co., Richland, WA (United States); Thurkow, T.J.; Fritz, R.L.; Nuhlestein, L.O.; Allen, M.R.; Stuart, R.J. [ARES Corp. (United States)

    1996-01-01

    A risk-based assessment of the overall waste volume versus double-shell tank storage capacity was conducted to develop fallback positions for projections where the waste volume was at a high risk of exceeding capacity. This study was initiated to provide that assessment. A working simulation model was the primary deliverable of this study. The model validates the approach and demonstrates that simulation analysis can provide a method of tracking uncertainties in available data, assessing probabilities, and serves as a tool to be used by management to determine the consequences of various off-normal occurrences.

  10. A risk management approach to double-shell tank waste volume versus storage capacity

    International Nuclear Information System (INIS)

    A risk-based assessment of the overall waste volume versus double-shell tank storage capacity was conducted to develop fallback positions for projections where the waste volume was at a high risk of exceeding capacity. This study was initiated to provide that assessment. A working simulation model was the primary deliverable of this study. The model validates the approach and demonstrates that simulation analysis can provide a method of tracking uncertainties in available data, assessing probabilities, and serves as a tool to be used by management to determine the consequences of various off-normal occurrences

  11. Comparison of theoretical approaches for computing the bond length alternation of polymethineimine

    Science.gov (United States)

    Jacquemin, Denis; Perpète, Eric A.; Chermette, Henry; Ciofini, Ilaria; Adamo, Carlo

    2007-01-01

    Using electron-correlated wavefunction approaches and several pure and hybrid density functionals combined with three atomic basis sets, we have optimized the ground-state geometry of increasingly long polymethineimine oligomers presenting all- trans and gliding-plane symmetries. It turns out that MP2 bond length alternations (BLA) are in good agreement with higher-order electron-correlated wavefunction approaches, whereas, for both conformers, large qualitative and quantitative discrepancies between MP2 and DFT geometries have been found. Indeed, all the selected GGA, meta-GGA and hybrid functionals tend to overestimate bond length equalization in extended polymethineimine structures. On the other hand, self-interaction corrections included in the ADSIC framework provide, in this particular case, a more efficient approach to predict the BLA for medium-size oligomers.

  12. Comparison of theoretical approaches for computing the bond length alternation of polymethineimine

    Energy Technology Data Exchange (ETDEWEB)

    Jacquemin, Denis [Laboratoire de Chimie Theorique Appliquee, Facultes Universitaires Notre-Dame de la Paix, rue de Bruxelles, 61, B-5000 Namur (Belgium)], E-mail: denis.jacquemin@fundp.ac.be; Perpete, Eric A. [Laboratoire de Chimie Theorique Appliquee, Facultes Universitaires Notre-Dame de la Paix, rue de Bruxelles, 61, B-5000 Namur (Belgium); Chermette, Henry [Laboratoire de Chimie Physique Theorique, Universite Claude Bernard, Lyon I Bat. 210, and CNRS UMR 5180 43, Boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex (France); Ciofini, Ilaria; Adamo, Carlo [Ecole Nationale Superieure de Chimie de Paris, Laboratoire Electrochimie et Chimie Analytique, UMR CNRS ENSCP no. 7575, rue Pierre et Marie Curie, 11 F-75321 Paris Cedex 05 (France)

    2007-01-25

    Using electron-correlated wavefunction approaches and several pure and hybrid density functionals combined with three atomic basis sets, we have optimized the ground-state geometry of increasingly long polymethineimine oligomers presenting all-trans and gliding-plane symmetries. It turns out that MP2 bond length alternations (BLA) are in good agreement with higher-order electron-correlated wavefunction approaches, whereas, for both conformers, large qualitative and quantitative discrepancies between MP2 and DFT geometries have been found. Indeed, all the selected GGA, meta-GGA and hybrid functionals tend to overestimate bond length equalization in extended polymethineimine structures. On the other hand, self-interaction corrections included in the ADSIC framework provide, in this particular case, a more efficient approach to predict the BLA for medium-size oligomers.

  13. A finite volume alternate direction implicit approach to modeling selective laser melting

    DEFF Research Database (Denmark)

    Hattel, Jesper Henri; Mohanty, Sankhya

    2013-01-01

    Over the last decade, several studies have attempted to develop thermal models for analyzing the selective laser melting process with a vision to predict thermal stresses, microstructures and resulting mechanical properties of manufactured products. While a holistic model addressing all involved...... is proposed for modeling single-layer and few-layers selective laser melting processes. The ADI technique is implemented and applied for two cases involving constant material properties and non-linear material behavior. The ADI FV method consume less time while having comparable accuracy with respect to 3D...

  14. Evaluating Today's Landscape Multifunctionality and Providing an Alternative Future: A Normative Scenario Approach

    Directory of Open Access Journals (Sweden)

    Patrick Sheridan

    2010-09-01

    Full Text Available Intensive agriculture has had multiple negative effects on the environment across large areas of Europe, including a decrease in the degree to which these landscapes serve multiple functions. A quantitative evaluation of the deficits in landscape multifunctionality is difficult, however, for a given landscape as long as "multifunctional reference landscapes" are lacking. We present an interdisciplinary normative scenario approach to overcome this obstacle. Given the example of the lower Wetter-catchment in the Wetterau region (Hesse, Germany, we compare the existing landscape with an expert-generated multifunctional landscape scenario that may also serve as an alternative future. This approach may inspire policy makers and land users by providing a methodology for the design of alternative multifunctional futures in five steps: (1 documentation of today's landscape structure and land use at the scale of uniformly managed land units; (2 detection of functional deficits of today's landscape considering environmental (soil contamination, groundwater production, water quality, biodiversity, economic (land rent, and societal (landscape perception by its population attributes; (3 compilation of a catalogue of alternative land uses (including linear landscape elements suitable to minimize the detected functional deficits; (4 rule-based modification of today's land-use pattern into a normative scenario; and (5 comparison of today's landscape and the normative scenario by applying the model network ITE²M. Results highlight a strongly unbalanced allocation of private and public goods in today's landscape with severe deficits in environmental and societal landscape features, but a significantly higher land rent. The designed multifunctional scenario, instead, may be preferred by the local population, and their willingness to pay for multifunctionality could potentially compensate calculated opportunity costs. Hence, the generated landscape scenario may be

  15. Negative Return-Volume Relationship in Asian Stock Markets: Figarch-Copula Approach

    Directory of Open Access Journals (Sweden)

    Muhammad Naeem

    2014-09-01

    Full Text Available We explore the potential dependence among different Asian stock markets, using several different statistical models. Extreme return-volume dependence in Hong Kong Seng Index, Bombay Stock Exchange, Indonesia Composite Index and Bursa Malaysia has been examined by using FIGARCH-Copula and GARCH-Copula approach. We have used Gaussian, Student-t, Frank, Clayton, Survival Clayton and Gumbel copulas. Based on Akaike information criterion (AIC, we found that using FIGARCH model for return series improves the results of copula parameter estimation. According to our finding, Hong Kong and Indian stock indices showed weak upper tail dependence between return and volume. Further, we have found that the extremely low returns for Malaysia and Indonesia stock indices are followed by high volumes, providing evidence of leverage effect. Our investigation shows that Malaysia and Indonesia stock indices are sensitive to bad news rather than good news.

  16. An alternative functional renormalization group approach to the single impurity Anderson model

    OpenAIRE

    Kinza, Michael; Ortloff, Jutta; Bauer, Johannes; Honerkamp, Carsten

    2012-01-01

    We present an alternative functional renormalization group (fRG) approach to the single-impurity Anderson model at finite temperatures. Starting with the exact self-energy and interaction vertex of a small system ('core') containing a correlated site, we switch on the hybridization with a non-interacting bath in the fRG-flow and calculate spectra of the correlated site. Different truncations of the RG-flow-equations and choices of the core are compared and discussed. Furthermore we calculate ...

  17. An alternative experimental approach for subcritical configurations of the IPEN/MB-01 nuclear reactor

    Science.gov (United States)

    Gonnelli, E.; Lee, S. M.; Pinto, L. N.; Landim, H. R.; Diniz, R.; Jerez, R.; dos Santos, A.

    2015-07-01

    This work presents an alternative approach for the reactivity worth experiments analysis in the IPEN/MB-01 reactor considering highly subcritical arrays. In order to reach the subcritical levels, the removal of a specific number of fuel rods is proposed. Twenty three configurations were carried out for this purpose. The control bank insertion experiment was used only as reference for the fuel rod experiment and, in addition, the control banks were maintained completely withdrawn during all the fuel rods experiment. The theoretical simulation results using the MCNP5 code and the ENDF/B-VII.0 library neutron data are in a very good agreement to experimental results.

  18. An alternative data filling approach for prediction of missing data in soft sets (ADFIS).

    Science.gov (United States)

    Sadiq Khan, Muhammad; Al-Garadi, Mohammed Ali; Wahab, Ainuddin Wahid Abdul; Herawan, Tutut

    2016-01-01

    Soft set theory is a mathematical approach that provides solution for dealing with uncertain data. As a standard soft set, it can be represented as a Boolean-valued information system, and hence it has been used in hundreds of useful applications. Meanwhile, these applications become worthless if the Boolean information system contains missing data due to error, security or mishandling. Few researches exist that focused on handling partially incomplete soft set and none of them has high accuracy rate in prediction performance of handling missing data. It is shown that the data filling approach for incomplete soft set (DFIS) has the best performance among all previous approaches. However, in reviewing DFIS, accuracy is still its main problem. In this paper, we propose an alternative data filling approach for prediction of missing data in soft sets, namely ADFIS. The novelty of ADFIS is that, unlike the previous approach that used probability, we focus more on reliability of association among parameters in soft set. Experimental results on small, 04 UCI benchmark data and causality workbench lung cancer (LUCAP2) data shows that ADFIS performs better accuracy as compared to DFIS. PMID:27588241

  19. Negative Return-Volume Relationship in Asian Stock Markets: Figarch-Copula Approach

    OpenAIRE

    Muhammad Naeem; Hao Ji; Brunero Liseo

    2014-01-01

    We explore the potential dependence among different Asian stock markets, using several different statistical models. Extreme return-volume dependence in Hong Kong Seng Index, Bombay Stock Exchange, Indonesia Composite Index and Bursa Malaysia has been examined by using FIGARCH-Copula and GARCH-Copula approach. We have used Gaussian, Student-t, Frank, Clayton, Survival Clayton and Gumbel copulas. Based on Akaike information criterion (AIC), we found that using FIGARCH model for ...

  20. Surfactant-mediated cloud point extractions: An environmentally benign alternative separation approach

    Energy Technology Data Exchange (ETDEWEB)

    Quina, F.H.; Hinze, W.L.

    1999-11-01

    Aqueous solutions of certain surfactant micelles exhibit phase separation behavior upon temperature alteration. This phenomenon can be exploited in separation science for the development of extraction, purification, and preconcentration schemes for desired analyses. Since the addition of just a small amount of an appropriate nonionic or zwitterionic surfactant to the aqueous sample solution is required, this approach is convenient and fairly benign, eliminating the need for the use of organic solvents as in conventional liquid-liquid or solid-liquid extraction. The basic features, experimental protocols, and selected recent applications of this alternative extraction approach, termed cloud point extraction (CPE) or micelle-mediated extraction (ME), are briefly reviewed. In addition, the advantages, limitations, and anticipated future directions of this methodology are discussed.

  1. Imaging MALDI MS of Dosed Brain Tissues Utilizing an Alternative Analyte Pre-extraction Approach

    Science.gov (United States)

    Quiason, Cristine M.; Shahidi-Latham, Sheerin K.

    2015-06-01

    Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry has been adopted in the pharmaceutical industry as a useful tool to detect xenobiotic distribution within tissues. A unique sample preparation approach for MALDI imaging has been described here for the extraction and detection of cobimetinib and clozapine, which were previously undetectable in mouse and rat brain using a single matrix application step. Employing a combination of a buffer wash and a cyclohexane pre-extraction step prior to standard matrix application, the xenobiotics were successfully extracted and detected with an 8 to 20-fold gain in sensitivity. This alternative approach for sample preparation could serve as an advantageous option when encountering difficult to detect analytes.

  2. An alternative approach to reconstructing organic matter accumulation with contrasting watershed disturbance histories from lake sediments

    International Nuclear Information System (INIS)

    A number of proxies, including carbon to nitrogen ratio (C:N) and stable isotopes (δ13C and δ15N), have been used to reconstruct organic matter (OM) profiles from lake sediments and these proxies individually or in combination cannot clearly discriminate different sources. Here we present an alternative approach to elucidate this problem from lake sediments as a function of watershed scale land use changes. Stable isotope signatures of defined OM sources from the study watersheds, Shawnigan Lake (SHL) and Elk Lake (ELL), were compared with sedimentary proxy records. Results from this study reveal that terrestrial inputs and catchment soil coinciding with the watershed disturbances histories probably contributed in recent trophic enrichment in SHL. In contrast, cultural eutrophication in ELL was partially a result of input from catchment soil (agricultural activities) with significant input from lake primary production as well. Results were consistent in both IsoSource (IsoSource version 1.2 is a Visual Basic program used for source separation, ( (http://www.epa.gov/wed/pages/models/isosource/isosource.htm)) and discriminant analysis (statistical classification technique). - The study shows an alternative approach to reconstruct organic matter accumulation using stable isotopes from lake sediments

  3. EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2015)

    OpenAIRE

    ZUANG Valerie; DESPREZ BERTRAND; VIEGAS BARROSO JOAO FILIPE; BELZ SUSANNE; BERGGREN ELISABET; Bernasconi, Camilla; BESSEMS JOSEPH; BOPP Stephanie; CASATI Silvia; Coecke, Sandra; Corvi, Raffaella; DUMONT CORALIE; GOULIARMOU VARVARA; GRIESINGER Claudius; HALDER MARIA ELISABETH

    2015-01-01

    The EURL ECVAM status report provides an update on the progress made in the development, validation and regulatory acceptance of alternative methods and approaches and their dissemination since the last report published in June 2014. It is informing on ongoing research and development activities, validation studies, peer reviews, recommendations, strategies and regulatory/international acceptance of alternative methods and approaches and dissemination activities. R&D activities within l...

  4. Patterns of failure after the reduced volume approach for elective nodal irradiation in nasopharyngeal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Seol, Ki Ho; Lee, Jeong Eun [Dept. of Radiation Oncology, Kyungpook National University School of Medicine, Daegu (Korea, Republic of)

    2016-03-15

    To evaluate the patterns of nodal failure after radiotherapy (RT) with the reduced volume approach for elective neck nodal irradiation (ENI) in nasopharyngeal carcinoma (NPC). Fifty-six NPC patients who underwent definitive chemoradiotherapy with the reduced volume approach for ENI were reviewed. The ENI included retropharyngeal and level II lymph nodes, and only encompassed the echelon inferior to the involved level to eliminate the entire neck irradiation. Patients received either moderate hypofractionated intensity-modulated RT for a total of 72.6 Gy (49.5 Gy to elective nodal areas) or a conventional fractionated three-dimensional conformal RT for a total of 68.4-72 Gy (39.6-45 Gy to elective nodal areas). Patterns of failure, locoregional control, and survival were analyzed. The median follow-up was 38 months (range, 3 to 80 months). The out-of-field nodal failure when omitting ENI was none. Three patients developed neck recurrences (one in-field recurrence in the 72.6 Gy irradiated nodal area and two in the elective irradiated region of 39.6 Gy). Overall disease failure at any site developed in 11 patients (19.6%). Among these, there were six local failures (10.7%), three regional failures (5.4%), and five distant metastases (8.9%). The 3-year locoregional control rate was 87.1%, and the distant failure-free rate was 90.4%; disease-free survival and overall survival at 3 years was 80% and 86.8%, respectively. No patient developed nodal failure in the omitted ENI site. Our investigation has demonstrated that the reduced volume approach for ENI appears to be a safe treatment approach in NPC.

  5. An Electric Field Volume Integral Equation Approach to Simulate Surface Plasmon Polaritons

    Directory of Open Access Journals (Sweden)

    Rob Remis

    2013-02-01

    Full Text Available In this paper we present an electric field volume integral equation approach to simulate surface plasmon propagation along metal/dielectric interfaces. Metallic objects embedded in homogeneous dielectric media are considered. Starting point is a so-called weak-form of the electric field integral equation. This form is discretized on a uniform tensor-product grid resulting in a system matrix whose action on a vector can be computed via the fast Fourier transform. The GMRES iterative solver is used to solve the discretized set of equations and numerical examples, illustrating surface plasmon propagation, are presented. The convergence rate of GMRES is discussed in terms of the spectrum of the system matrix and through numerical experiments we show how the eigenvalues of the discretized volume scattering operator are related to plasmon propagation and the medium parameters of a metallic object.

  6. Bronchoscopic lung volume reduction

    Directory of Open Access Journals (Sweden)

    M. I. Polkey

    2006-12-01

    Full Text Available Surgical lung volume reduction can improve exercise performance and forced expiratory volume in one second in patients with emphysema. However, the procedure is associated with a 5% mortality rate and a nonresponse rate of 25%. Accordingly, interest has focused on alternative ways of reducing lung volume. Two principle approaches are used: collapse of the diseased area using blockers placed endobronchially and the creation of extrapulmonary pathways. Preliminary data from the former approach suggest that it can be successful and that the magnitude of success is related to reduction in dynamic hyperinflation.

  7. Understanding anorexia: an hermeneutic approach as a methodological alternative for the field of contemporary anorexia research

    Directory of Open Access Journals (Sweden)

    Anne Puuronen

    1999-01-01

    Full Text Available Theories of anorexia nervosa have mainly been dominated by psychiatry and concentrate upon its physiological aspects, both in diagnosis and treatment. This has led to a search for organic causes behind anorectic conditions, instead of seeing it as molded and shaped both by the individual and the socio-cultural context. This "medicalisation" has been an impediment to a more complete conceptualisation of the experience of discipline and of the ascetic modes of action in anorexia. The intension is to approach anorexia as lived process. The focus is not in explaining what cause anorexia, but is centered on the contents of living experience as such. Thus, the author proposes a phenomenological approach to anorexia as a methodological alternative compared to the dominant medico-psychological approaches to anorexia of today. If we consider the body of an anorectic person as an intersection in which the subject's relationship to social reality will be materialized and verified, we are able to see first how accurate a picture of the dual meanings, double bindings and paradoxical commitments of our present culture and its relation to a woman's body anorexia will draw up. Also, because the fact is that anorexia is a predominantly "women's" illness we have to take in account that the construction of subjectivity and in this context the construction of a lived anorectic experience of discipline, is not a gender-neutral process.

  8. Alternative approaches for better municipal solid waste management in Mumbai, India

    International Nuclear Information System (INIS)

    Waste is an unavoidable by product of human activities. Economic development, urbanization and improving living standards in cities, have led to an increase in the quantity and complexity of generated waste. Rapid growth of population and industrialization degrades the urban environment and places serious stress on natural resources, which undermines equitable and sustainable development. Inefficient management and disposal of solid waste is an obvious cause of degradation of the environment in most cities of the developing world. Municipal corporations of the developing countries are not able to handle increasing quantities of waste, which results in uncollected waste on roads and in other public places. There is a need to work towards a sustainable waste management system, which requires environmental, institutional, financial, economic and social sustainability. This study explores alternative approaches to municipal solid waste (MSW) management and estimates the cost of waste management in Mumbai, India. Two alternatives considered in the paper are community participation and public private partnership in waste management. Data for the present study are from various non-governmental organizations (NGOs) and from the private sector involved in waste management in Mumbai. Mathematical models are used to estimate the cost per ton of waste management for both of the alternatives, which are compared with the cost of waste management by Municipal Corporation of Greater Mumbai (MCGM). It is found that the cost per ton of waste management is Rs. 1518 (US$35) with community participation; Rs. 1797 (US$41) with public private partnership (PPP); and Rs. 1908 (US$44) when only MCGM handles the waste. Hence, community participation in waste management is the least cost option and there is a strong case for comprehensively involving community participation in waste management

  9. An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes.

    Science.gov (United States)

    Gissi, Andrea; Gadaleta, Domenico; Floris, Matteo; Olla, Stefania; Carotti, Angelo; Novellino, Ettore; Benfenati, Emilio; Nicolotti, Orazio

    2014-01-01

    The REACH (Registration, Evaluation, Authorization and restriction of Chemicals) and BPR (Biocide Product Regulation) regulations strongly promote the use of non-animal testing techniques to evaluate chemical risk. This has renewed the interest towards alternative methods such as QSAR in the regulatory context. The assessment of Bioconcentration Factor (BCF) required by these regulations is expensive, in terms of costs, time, and laboratory animal sacrifices. Herein, we present QSAR models based on the ANTARES dataset, which is a large collection of known and verified experimental BCF data. Among the models developed, the best results were obtained from a nine-descriptor highly predictive model. This model was derived from a training set of 608 chemicals and challenged against a validation and blind set containing 152 and 76 chemicals. The model's robustness was further controlled through several validation strategies and the implementation of a multi-step approach for the applicability domain. Suitable safety margins were used to increase sensitivity. The easy interpretability of the model is ensured by the use of meaningful biokinetics descriptors. The satisfactory predictive power for external compounds suggests that the new models could represent a reliable alternative to the in vivo assay, helping the registrants to fulfill regulatory requirements in compliance with the ethical and economic necessity to reduce animal testing. PMID:24247988

  10. Anterior sagittal anorectoplasty: An alternative to posterior approach in management of congenital vestibular fistula

    Directory of Open Access Journals (Sweden)

    Man Mohan Harjai

    2013-01-01

    Full Text Available Background: Better exposure, possibility of extension if needed and precise placement of the anal canal within the external sphincter complex have made the posterior and anterior sagittal approaches more popular and established for the correction of anovestibular fistula. The mini posterior sagittal anorectoplasty (PSARP was the procedure of choice for female ARM at our center till date. As an alternative surgical option, we performed anterior sagittal anorectoplasty (ASARP in 15 cases of anovestibular fistula and compared them with 12 cases of vestibular fistula operated by PSARP technique. Patients and Methods: Fifteen female infants with vestibular fistula who had anterior sagittal anorectoplasty (ASARP procedure were reviewed. The procedure and its outcome were evaluated. Results : The manoeuvering during anesthesia and operative access were quite easier in ASARP compared to PSARP. Delineation of plane in ASARP between rectum and vagina was easier and clearer in comparison to PSARP. Rent occurred in the posterior vaginal wall in three cases of ASARP and two cases of PSARP. There were two cases of wound infection in each group. Three cases of PSARP group developed anal stenosis and constipation while one in the ASARP group developed constipation. Conclusion : Anesthesia and access in ASARP makes it an easier alternative option to PSARP in the management of anovestibular fistula in girls.

  11. Management of spent oxide fuel from thermal reactors: the environmental and radiological effects of alternative approaches

    International Nuclear Information System (INIS)

    The report presents the results of a study of the environmental and radiological effects of alternative approaches to the management of spent oxide fuel from the UK nuclear power programme. The two main alternatives are extended storage of the fuel, pending decisions on fissile material recycle, and reprocessing of the fuel commencing in the early 1990s. A review is made of experience in spent fuel storage, of the technical issues in long-term storage and of the possible needs of the UK nuclear programme. The main environmental and radiological effects of reprocessing considered in the study are the generation of radioactive wastes, the release of radioactivity in effluents with the resulting radiation exposure of the public, and occupational radiation exposure. The influence of the delay between reprocessing and fabrication of mixed oxide fuel on the environmental and radiological effects of plutonium recycle is investigated and it is shown that the effects would be minimised if reprocessing were delayed until there was a requirement for recycle. Strategies for the management of heavy elements other than plutonium are discussed and results are presented illustrating aspects of actinide management. (author)

  12. Alternative Approaches to Calculate Benefits of an Energy Imbalance Market With Wind and Solar Energy: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Kirby, B.; King, J.; Milligan, M.

    2012-06-01

    The anticipated increase in variable generation in the Western Interconnection over the next several years has raised concerns about how to maintain system balance, especially in smaller Balancing Authority Areas (BAAs). Given renewable portfolio standards in the West, it is possible that more than 50 gigawatts of wind capacity will be installed by 2020. Significant quantities of solar generation are likely to be added as well. The consequent increase in variability and uncertainty that must be managed by the conventional generation fleet and responsive loads has resulted in a proposal for an Energy Imbalance Market (EIM). This paper extends prior work to estimate the reserve requirements for regulation, spinning, and non-spinning reserves with and without the EIM. We also discuss alternative approaches to allocating reserve requirements and show that some apparently attractive allocation methods have undesired consequences.

  13. Management of Crohn's disease in smokers: Is an alternative approach necessary?

    Institute of Scientific and Technical Information of China (English)

    Pilar Nos; Eugeni Domènech

    2011-01-01

    Inflammatory bowel disease (IBD) is a chronic condition with a pathogenic background that involves both genetic and environmental factors. Although important progress has been made regarding the former in the last decade, scarce knowledge is available for the latter. In this sense, smoking remains the most important environmental factor in IBD. Active smoking increases the risk of developing Crohn's disease (CD). Moreover, CD patients who start or continue smoking after disease diagnosis are at risk for poorer outcomes such as higher therapeutic requirements and disease-related complications, as compared to those patients who quit smoking or who never smoked. However, the harmful effect of active smoking is not uniform in all patients or in all clinical scenarios. Interventions designed to facilitate smoking cessation may impact the course of the disease. In this article, the available evidence of the deleterious effects of smoking on CD is reviewed in detail, and alternative therapeutic approaches to CD in smokers are proposed.

  14. An alternative approach to prescribing sternal precautions after median sternotomy, "Keep Your Move in the Tube".

    Science.gov (United States)

    Adams, Jenny; Lotshaw, Ana; Exum, Emelia; Campbell, Mark; Spranger, Cathy B; Beveridge, Jim; Baker, Shawn; McCray, Stephanie; Bilbrey, Tim; Shock, Tiffany; Lawrence, Anne; Hamman, Baron L; Schussler, Jeffrey M

    2016-01-01

    Traditional sternal precautions, given to sternotomy patients as part of their discharge education, are intended to help prevent sternal wound complications. They vary widely but generally include arbitrary load and time restrictions (lifting no more than a specified weight for up to 12 weeks) and may prohibit common shoulder joint and shoulder girdle movements. Having observed the negative effects of restrictive sternal precautions for many years, our research team performed a series of studies that measured the forces exerted during various common activities and their relationship to the sternum. The results, though informative, led us to realize that the goal of identifying "the" appropriate load restriction to prescribe for sternotomy patients was futile. The alternative approach that we introduce applies standard kinesiological principles and teaches patients how to perform load-bearing movements in a way that avoids excessive stress to the sternum. PMID:26722187

  15. Towards electromechanical computation: An alternative approach to realize complex logic circuits

    Science.gov (United States)

    Hafiz, M. A. A.; Kosuru, L.; Younis, M. I.

    2016-08-01

    Electromechanical computing based on micro/nano resonators has recently attracted significant attention. However, full implementation of this technology has been hindered by the difficulty in realizing complex logic circuits. We report here an alternative approach to realize complex logic circuits based on multiple MEMS resonators. As case studies, we report the construction of a single-bit binary comparator, a single-bit 4-to-2 encoder, and parallel XOR/XNOR and AND/NOT logic gates. Toward this, several microresonators are electrically connected and their resonance frequencies are tuned through an electrothermal modulation scheme. The microresonators operating in the linear regime do not require large excitation forces, and work at room temperature and at modest air pressure. This study demonstrates that by reconfiguring the same basic building block, tunable resonator, several essential complex logic functions can be achieved.

  16. Towards electromechanical computation: An alternative approach to realize complex logic circuits

    KAUST Repository

    Hafiz, M. A. A.

    2016-08-18

    Electromechanical computing based on micro/nano resonators has recently attracted significant attention. However, full implementation of this technology has been hindered by the difficulty in realizing complex logic circuits. We report here an alternative approach to realize complex logic circuits based on multiple MEMS resonators. As case studies, we report the construction of a single-bit binary comparator, a single-bit 4-to-2 encoder, and parallel XOR/XNOR and AND/NOT logic gates. Toward this, several microresonators are electrically connected and their resonance frequencies are tuned through an electrothermal modulation scheme. The microresonators operating in the linear regime do not require large excitation forces, and work at room temperature and at modest air pressure. This study demonstrates that by reconfiguring the same basic building block, tunable resonator, several essential complex logic functions can be achieved.

  17. An Alternative Dimension Reduction Approach to Supervised Principal Components Analysis in High Dimensional Survival Data

    Directory of Open Access Journals (Sweden)

    Elvan AKTURK HAYAT

    2016-04-01

    Full Text Available Objective: This study aims at comparing the performances of supervised principal component analysis (SPCA which is used for dimension reduction and an alternatively proposed approach of nonlinear principal component analysis using artificial neural networks performed by gene selection with survival tree (survival tree based NLPCA- NN. Material and Methods: Gene expression data set from Rosenwald et al.(2002 pertaining to 240 patients with diffuse large B-cell lymphoma (DLBCL is used. While Cox scores are used for determining important genes from high dimensional gene expression data in SPCA, in survival tree based NLPCA-NN approach, importance values of the survival tree are used. Important genes according to the Cox scores are reduced to three principal components by singular value decomposition. Important genes determined by the survival tree are taken as input variables in neural networks and reduced to three principal components. The performances of SPCA and survival tree based NLPCA-NN are compared by using Cox regression models (CRM. C index is calculated to compare obtained Cox regression models. Results: According to Cox scores, 121 genes are determined; according to importance values of survival tree 114 genes are determined. The percentages of variances explained by SPCA and survival tree based NLPCA-NN were 18.2% and 35.1% respectively. Harrell?s C indexes are calculated as 0.726 for CRM-1, 0.687 for CRM-2. Conclusion: As a result, while SPCA takes only the linear relationships into consideration, survival tree based NLPCA-NN also takes non-linear relationships into account and has more variance explanation and NLPCA-NN can be evaluated as an alternative method to SPCA.

  18. Associative memory in a volume holographic medium: a new approach based on operator theory

    International Nuclear Information System (INIS)

    In this article, we present a new method for holographic implementation of associative memories. In the current approach, the memory capacity is implemented in the form of spatial perturbation of refractive index within the volume of a three dimensional holographic material. We use operator theory to solve the inverse problem and compute a closed-form solution for the spatial distribution of the perturbation considering any arbitrary set of input–output prototype vectors. Simplicity of the hardware is the major advantage of the current method. (papers)

  19. Associative memory in a volume holographic medium: a new approach based on operator theory

    Science.gov (United States)

    Pashaie, Ramin

    2014-07-01

    In this article, we present a new method for holographic implementation of associative memories. In the current approach, the memory capacity is implemented in the form of spatial perturbation of refractive index within the volume of a three dimensional holographic material. We use operator theory to solve the inverse problem and compute a closed-form solution for the spatial distribution of the perturbation considering any arbitrary set of input-output prototype vectors. Simplicity of the hardware is the major advantage of the current method.

  20. A Cost Comparison of Alternative Approaches to Distance Education in Developing Countries

    Science.gov (United States)

    Ventre, Gerard G.; Kalu, Alex

    1996-01-01

    This paper presents a cost comparison of three approaches to two-way interactive distance learning systems for developing countries. Included are costs for distance learning hardware, terrestrial and satellite communication links, and designing instruction for two-way interactive courses. As part of this project, FSEC is developing a 30-hour course in photovoltaic system design that will be used in a variety of experiments using the Advanced Communications Technology Satellite (ACTS). A primary goal of the project is to develop an instructional design and delivery model that can be used for other education and training programs. Over two-thirds of the world photovoltaics market is in developing countries. One of the objectives of this NASA-sponsored project was to develop new and better energy education programs that take advantage of advances in telecommunications and computer technology. The combination of desktop video systems and the sharing of computer applications software is of special interest. Research is being performed to evaluate the effectiveness of some of these technologies as part of this project. The design of the distance learning origination and receive sites discussed in this paper were influenced by the educational community's growing interest in distance education. The following approach was used to develop comparative costs for delivering interactive distance education to developing countries: (1) Representative target locations for receive sites were chosen. The originating site was assumed to be Cocoa, Florida, where FSEC is located; (2) A range of course development costs were determined; (3) The cost of equipment for three alternative two-way interactive distance learning system configurations was determined or estimated. The types of system configurations ranged from a PC-based system that allows instructors to originate instruction from their office using desktop video and shared application software, to a high cost system that uses a

  1. Challenges and implications of global modeling approaches that are alternatives to using constant plant functional types

    Science.gov (United States)

    Bodegom, P. V.

    2015-12-01

    In recent years a number of approaches have been developed to provide alternatives to the use of plant functional types (PFTs) with constant vegetation characteristics for simulating vegetation responses to climate changes. In this presentation, an overview of those approaches and their challenges is given. Some new approaches aim at removing PFTs altogether by determining the combination of vegetation characteristics that would fit local conditions best. Others describe the variation in traits within PFTs as a function of environmental drivers, based on community assembly principles. In the first approach, after an equilibrium has been established, vegetation composition and its functional attributes can change by allowing the emergence of a new type that is more fit. In the latter case, changes in vegetation attributes in space and time as assumed to be the result intraspecific variation, genetic adaptation and species turnover, without quantifying their respective importance. Hence, it is assumed that -by whatever mechanism- the community as a whole responds without major time lags to changes in environmental drivers. Recently, we showed that intraspecific variation is highly species- and trait-specific and that none of the current hypotheses on drivers of this variation seems to hold. Also genetic adaptation varies considerably among species and it is uncertain whether it will be fast enough to cope with climate change. Species turnover within a community is especially fast in herbaceous communities, but much slower in forest communities. Hence, it seems that assumptions made may not hold for forested ecosystems, but solutions to deal with this do not yet exist. Even despite the fact that responsiveness of vegetation to environmental change may be overestimated, we showed that -upon implementation of trait-environment relationships- major changes in global vegetation distribution are projected, to similar extents as to those without such responsiveness.

  2. Morphological study of surgical approach by superior temporal sulcus-temporal horn of lateral ventricle approach using volume rendering.

    Science.gov (United States)

    Sun, Wei; Jia, Linpei; Dong, Yidian; Zhao, Hang; Liu, Haoyuan; Yang, Kerong; Li, Youqiong

    2014-03-01

    In this research, we acquired the length of the superior temporal sulcus, the shortest distance from the superior temporal sulcus to the temporal horn of the lateral ventricle, and the approach angle between the median sagittal plane and the shortest segment from the superior temporal sulcus to the temporal horn of the lateral ventricle measuring 98 specimens by magnetic resonance imaging volume rendering. At the same time, we preliminarily oriented the point of the superior temporal sulcus, which is closest to the temporal horn of the lateral ventricle, aimed at finding out the best entrance point of surgical approach through the superior temporal sulcus to the temporal horn of the lateral ventricle and reducing the damage to optic radiation as well as other nerve fibers during the operation. The results indicate that the point at the front side 3/5 of the superior temporal sulcus may be the ideal surgical approach entrance point, and there is no difference between 2 cerebral hemispheres (P < 0.05).

  3. Structured assessment approach: Version I. Applied demonstration of output results. Volume 3

    Energy Technology Data Exchange (ETDEWEB)

    Parziale, A.A.; Sacks, 1.J.

    1979-10-01

    A methodology, the Structured Assessment Approach, has been developed for the assessment of the effectiveness of material control and accounting (MC and A) safeguards systems at nuclear fuel cycle facilities. This methodology has been refined into a computational tool, the SAA Version 1 computational package, that was used first to analyze a hypothetical fuel cycle facility (HFCF) and used more recently to assess operational nuclear plants. The Version 1 analysis package is designed to analyze safeguards systems that prevent the diversion of special nuclear material (SNM) from nuclear fuel cycle facilities and to provide assurance that diversion has not occurred. This report is the third volume, Applied Demonstration of Output Results, of a four-volume document. It presents the outputs for each of the four levels of the SAA Version 1 computational package. Two types of outputs are discussed: detailed output findings and summary output tables. The summary output tables are used to aggregate the detailed output findings in a condensed form for NRC analyst consumption. Specific output results are presented for an HFCF, which is described in Volume II.

  4. Report on noninvasive prenatal testing: classical and alternative approaches [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Kateryna S. Pantiukh

    2016-04-01

    Full Text Available Concerns of traditional prenatal aneuploidy testing methods, such as low accuracy of noninvasive and health risks associated with invasive procedures, were overcome with the introduction of novel noninvasive methods based on genetics (NIPT. These were rapidly adopted into clinical practice in many countries after a series of successful trials of various independent submethods. Here we present results of own NIPT trial carried out in Moscow, Russia. 1012 samples were subjected to the method aimed at measuring chromosome coverage by massive parallel sequencing. Two alternative approaches are ascertained: one based on maternal/fetal differential methylation and another based on allelic difference. While the former failed to provide stable results, the latter was found to be promising and worthy of conducting a large-scale trial. One critical point in any NIPT approach is the determination of fetal cell-free DNA fraction, which dictates the reliability of obtained results for a given sample. We show that two different chromosome Y representation measures—by real-time PCR and by whole-genome massive parallel sequencing—are practically interchangeable (r=0.94. We also propose a novel method based on maternal/fetal allelic difference which is applicable in pregnancies with fetuses of either sex. Even in its pilot form it correlates well with chromosome Y coverage estimates (r=0.74 and can be further improved by increasing the number of polymorphisms.

  5. Alternative 3D Modeling Approaches Based on Complex Multi-Source Geological Data Interpretation

    Institute of Scientific and Technical Information of China (English)

    李明超; 韩彦青; 缪正建; 高伟

    2014-01-01

    Due to the complex nature of multi-source geological data, it is difficult to rebuild every geological struc-ture through a single 3D modeling method. The multi-source data interpretation method put forward in this analysis is based on a database-driven pattern and focuses on the discrete and irregular features of geological data. The geological data from a variety of sources covering a range of accuracy, resolution, quantity and quality are classified and inte-grated according to their reliability and consistency for 3D modeling. The new interpolation-approximation fitting construction algorithm of geological surfaces with the non-uniform rational B-spline (NURBS) technique is then pre-sented. The NURBS technique can retain the balance among the requirements for accuracy, surface continuity and data storage of geological structures. Finally, four alternative 3D modeling approaches are demonstrated with reference to some examples, which are selected according to the data quantity and accuracy specification. The proposed approaches offer flexible modeling patterns for different practical engineering demands.

  6. Alternative approach to precision narrow-angle astrometry for Antarctic long baseline interferometry

    CERN Document Server

    Kok, Y; Rizzuto, A C; Tuthill, P G; Robertson, J G; Warrington, B A; Tango, W J

    2014-01-01

    The conventional approach to high-precision narrow-angle astrometry using a long baseline interferometer is to directly measure the fringe packet separation of a target and a nearby reference star. This is done by means of a technique known as phase-referencing which requires a network of dual beam combiners and laser metrology systems. Using an alternative approach that does not rely on phase-referencing, the narrow-angle astrometry of several closed binary stars (with separation less than 2$"$), as described in this paper, was carried out by observing the fringe packet crossing event of the binary systems. Such an event occurs twice every sidereal day when the line joining the two stars of the binary is is perpendicular to the projected baseline of the interferometer. Observation of these events is well suited for an interferometer in Antarctica. Proof of concept observations were carried out at the Sydney University Stellar Interferometer (SUSI) with targets selected according to its geographical location....

  7. Alternate approaches to verifying the structural adequacy of the Defense High Level Waste Shipping Cask

    Energy Technology Data Exchange (ETDEWEB)

    Zimmer, A.; Koploy, M.

    1991-12-01

    In the early 1980s, the US Department of Energy/Defense Programs (DOE/DP) initiated a project to develop a safe and efficient transportation system for defense high level waste (DHLW). A long-standing objective of the DHLW transportation project is to develop a truck cask that represents the leading edge of cask technology as well as one that fully complies with all applicable DOE, Nuclear Regulatory Commission (NRC), and Department of Transportation (DOT) regulations. General Atomics (GA) designed the DHLW Truck Shipping Cask using state-of-the-art analytical techniques verified by model testing performed by Sandia National Laboratories (SNL). The analytical techniques include two approaches, inelastic analysis and elastic analysis. This topical report presents the results of the two analytical approaches and the model testing results. The purpose of this work is to show that there are two viable analytical alternatives to verify the structural adequacy of a Type B package and to obtain an NRC license. It addition, this data will help to support the future acceptance by the NRC of inelastic analysis as a tool in packaging design and licensing.

  8. Alternate approaches to verifying the structural adequacy of the Defense High Level Waste Shipping Cask

    International Nuclear Information System (INIS)

    In the early 1980s, the US Department of Energy/Defense Programs (DOE/DP) initiated a project to develop a safe and efficient transportation system for defense high level waste (DHLW). A long-standing objective of the DHLW transportation project is to develop a truck cask that represents the leading edge of cask technology as well as one that fully complies with all applicable DOE, Nuclear Regulatory Commission (NRC), and Department of Transportation (DOT) regulations. General Atomics (GA) designed the DHLW Truck Shipping Cask using state-of-the-art analytical techniques verified by model testing performed by Sandia National Laboratories (SNL). The analytical techniques include two approaches, inelastic analysis and elastic analysis. This topical report presents the results of the two analytical approaches and the model testing results. The purpose of this work is to show that there are two viable analytical alternatives to verify the structural adequacy of a Type B package and to obtain an NRC license. It addition, this data will help to support the future acceptance by the NRC of inelastic analysis as a tool in packaging design and licensing

  9. A white matter lesion-filling approach to improve brain tissue volume measurements

    Directory of Open Access Journals (Sweden)

    Sergi Valverde

    2014-01-01

    Full Text Available Multiple sclerosis white matter (WM lesions can affect brain tissue volume measurements of voxel-wise segmentation methods if these lesions are included in the segmentation process. Several authors have presented different techniques to improve brain tissue volume estimations by filling WM lesions before segmentation with intensities similar to those of WM. Here, we propose a new method to refill WM lesions, where contrary to similar approaches, lesion voxel intensities are replaced by random values of a normal distribution generated from the mean WM signal intensity of each two-dimensional slice. We test the performance of our method by estimating the deviation in tissue volume between a set of 30 T1-w 1.5 T and 30 T1-w 3 T images of healthy subjects and the same images where: WM lesions have been previously registered and afterwards replaced their voxel intensities to those between gray matter (GM and WM tissue. Tissue volume is computed independently using FAST and SPM8. When compared with the state-of-the-art methods, on 1.5 T data our method yields the lowest deviation in WM between original and filled images, independently of the segmentation method used. It also performs the lowest differences in GM when FAST is used and equals to the best method when SPM8 is employed. On 3 T data, our method also outperforms the state-of-the-art methods when FAST is used while performs similar to the best method when SPM8 is used. The proposed technique is currently available to researchers as a stand-alone program and as an SPM extension.

  10. Hawaii Integrated Energy Assessment. Volume V. Rules, regulations, permits and policies affecting the development of alternate energy sources in Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    A comprehensive presentaton of the major permits, regulations, rules, and controls which are likely to affect the development of alternate energy sources in Hawaii is presented. An overview of the permit process, showing the major categories and types of permits and controls for energy alternatives is presented. This is followed by a brief resume of current and projected changes designed to streamline the permit process. The permits, laws, regulations, and controls that are applicable to the development of energy alternatives in Hawaii are described. The alternate energy technologies affected, a description of the permit or control, and the requirements for conformance are presented for each applicable permit. Federal, state, and county permits and controls are covered. The individual energy technologies being considered as alternatives to the State's present dependence on imported fossil fuels are emphasized. The alternate energy sources covered are bioconversion, geothermal, ocean thermal, wind, solar (direct), and solid waste. For each energy alternative, the significant permits are summarized with a brief explanation of why they may be necessary. The framework of policy development at each of the levels of government with respect to the alternate energy sources is covered.

  11. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    This NASAP assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improvng the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness

  12. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This NASAP assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improvng the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness.

  13. Comparison of marine spatial planning methods in Madagascar demonstrates value of alternative approaches.

    Directory of Open Access Journals (Sweden)

    Thomas F Allnutt

    Full Text Available The Government of Madagascar plans to increase marine protected area coverage by over one million hectares. To assist this process, we compare four methods for marine spatial planning of Madagascar's west coast. Input data for each method was drawn from the same variables: fishing pressure, exposure to climate change, and biodiversity (habitats, species distributions, biological richness, and biodiversity value. The first method compares visual color classifications of primary variables, the second uses binary combinations of these variables to produce a categorical classification of management actions, the third is a target-based optimization using Marxan, and the fourth is conservation ranking with Zonation. We present results from each method, and compare the latter three approaches for spatial coverage, biodiversity representation, fishing cost and persistence probability. All results included large areas in the north, central, and southern parts of western Madagascar. Achieving 30% representation targets with Marxan required twice the fish catch loss than the categorical method. The categorical classification and Zonation do not consider targets for conservation features. However, when we reduced Marxan targets to 16.3%, matching the representation level of the "strict protection" class of the categorical result, the methods show similar catch losses. The management category portfolio has complete coverage, and presents several management recommendations including strict protection. Zonation produces rapid conservation rankings across large, diverse datasets. Marxan is useful for identifying strict protected areas that meet representation targets, and minimize exposure probabilities for conservation features at low economic cost. We show that methods based on Zonation and a simple combination of variables can produce results comparable to Marxan for species representation and catch losses, demonstrating the value of comparing alternative

  14. Coal conversion and biomass conversion: Volume 1: Final report on USAID (Agency for International Development)/GOI (Government of India) Alternate Energy Resources and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, A.; Saluja, J.

    1987-06-30

    The United States Agency for International Development (AID), in joint collaboration with the Government of India (GOI), supported a research and development program in Alternate Energy Resources during the period March 1983 to June 1987. The primary emphasis of this program was to develop new and advanced coal and biomass conversion technologies for the efficient utilization of coal and biomass feedstocks in India. This final ''summary'' report is divided into two volumes. This Report, Volume I, covers the program overview and coal projects and Volume II summarizes the accomplishments of the biomass projects. The six projects selected in the area of coal were: Evaluation of the Freeboard Performance in a Fluidized-Bed Combustor; Scale-up of AFBC boilers; Rheology, Stability and Combustion of Coal-Water Slurries; Beneficiation of Fine Coal in Dense Medium Cyclones; Hot Gas Cleanup and Separation; and Cold Gas Cleanup and Separation.

  15. Shifting Away From Fee-For-Service: Alternative Approaches to Payment in Gastroenterology.

    Science.gov (United States)

    Patel, Kavita; Presser, Elise; George, Meaghan; McClellan, Mark

    2016-04-01

    Fee-for-service payments encourage high-volume services rather than high-quality care. Alternative payment models (APMs) aim to realign financing to support high-value services. The 2 main components of gastroenterologic care, procedures and chronic care management, call for a range of APMs. The first step for gastroenterologists is to identify the most important conditions and opportunities to improve care and reduce waste that do not require financial support. We describe examples of delivery reforms and emerging APMs to accomplish these care improvements. A bundled payment for an episode of care, in which a provider is given a lump sum payment to cover the cost of services provided during the defined episode, can support better care for a discrete procedure such as a colonoscopy. Improved management of chronic conditions can be supported through a per-member, per-month (PMPM) payment to offer extended services and care coordination. For complex chronic conditions such as inflammatory bowel disease, in which the gastroenterologist is the principal care coordinator, the PMPM payment could be given to a gastroenterology medical home. For conditions in which the gastroenterologist acts primarily as a consultant for primary care, such as noncomplex gastroesophageal reflux or hepatitis C, a PMPM payment can support effective care coordination in a medical neighborhood delivery model. Each APM can be supplemented with a shared savings component. Gastroenterologists must engage with and be early leaders of these redesign discussions to be prepared for a time when APMs may be more prevalent and no longer voluntary. PMID:26122765

  16. The West Central Alberta Woodland Caribou Landscape Plan: Using a Modeling Approach to Develop Alternative Scenarios

    Directory of Open Access Journals (Sweden)

    Anne Hubbs

    2011-09-01

    Full Text Available Woodland caribou (Rangifer tarandus are classified as threatened in Alberta. In support of Canada's Species at Risk Act, a Recovery Plan for Woodland Caribou in Alberta was completed in 2004 which required local implementation plans to be completed within 5 areas of the province. The West Central Alberta Caribou Landscape Plan (WCCLP is the first of these to be initiated and it addresses the recovery strategies for 4 herds. Two aspatial computer models built on the STELLA© modelling platform (ISee Systems, 2007 were used to assist the planning team in evaluating cumulative effects and alternative scenarios for caribou conservation. The ALCES© (Forem Technologies 2008 modelling tool was used to forecast potential changes in the west central Alberta landscape over time. Yearly landscape condition outputs from ALCES© were then exported into a caribou-specific population model, REMUS© (Weclaw, 2004, that was used to project potential population responses by woodland caribou, other primary prey species [moose (Alces alces, elk (Cervus elaphus and deer (Odocoileus sp.] and wolves (Canis lupus (Weclaw & Hudson, 2004. Simulated habitat management strategies that resulted in the highest likelihood of caribou recovery included the maintenance of a high proportion of old forest, the aggregation of industrial footprints and the reclamation of historic seismic lines (although the latter took decades to provide real dividends. Sharing of industrial roads, protection of fragments of old-growth, and expanding an already aggressive fire control strategy in Alberta had little additional effect on caribou recovery. Simulated population management strategies that were successful all involved decades of intensive wolf control, either directly or indirectly through intensive primary prey control (with the exception of woodland caribou until old-growth forests recovered to densities that provided caribou habitat and decreased alternate prey of wolves. Although

  17. Promoting functional foods as acceptable alternatives to doping: potential for information-based social marketing approach

    Directory of Open Access Journals (Sweden)

    Petróczi Andrea

    2010-11-01

    Full Text Available Abstract Background Substances with performance enhancing properties appear on a continuum, ranging from prohibited performance enhancing drugs (PED through dietary supplements to functional foods (FF. Anti-doping messages designed to dissuade athletes from using PEDs have been typically based on moralising sport competition and/or employing scare campaigns with focus on the negative consequences. Campaigns offering comparable and acceptable alternatives are nonexistent, nor are athletes helped in finding these for themselves. It is timely that social marketing strategies for anti-doping prevention and intervention incorporate media messages that complement the existing approaches by promoting comparable and acceptable alternatives to doping. To facilitate this process, the aim of this study was to ascertain whether a single exposure knowledge-based information intervention led to increased knowledge and subsequently result in changes in beliefs and automatic associations regarding performance enhancements. Methods In a repeated measure design, 115 male recreational gym users were recruited and provided with a brief information pamphlet on nitrite/nitrate and erythropoietin as a comparison. Measures of knowledge, beliefs and automatic associations were taken before and after the intervention with at least 24 hours between the two assessments. The psychological tests included explicit measures of beliefs and cognitive attitudes toward FF and PED using a self-reported questionnaire and computerised assessments of automatic associations using the modified and shortened version of the Implicit Association Test. Results The information based intervention significantly increased knowledge (p p p Conclusion Evidence was found that even a single exposure to a persuasive positive message can lead to belief change and can create new or alter existing associations - but only in the specific domain. Interventions to change outcome expectations in a positive

  18. An integrated approach to shaping the future of alternative energy in Canada

    Energy Technology Data Exchange (ETDEWEB)

    James, D. [EnergyINet Inc., Calgary, AB (Canada)

    2005-07-01

    EnergyINet Inc. is an energy innovation network that is part of the Alberta Energy Research Institute and the Alberta Government. Its mandate is to link industry, government and academia to facilitate innovation and research in energy. The organization's strategic goals are to maintain a competitive energy supply, take advantage of the shift in energy systems and put Canada at the forefront of integration between energy systems. EnergyINet's value-added approach is to develop an integrated strategy that results in better industry participation and technology transfer while reducing the risk of costly investment in technology. Current innovation programs focus on oil sands upgrading; clean coal technology with carbon sequestration; enhanced recovery; alternate and renewable energy; water management and carbon dioxide management. The organization's cross-cutting initiatives include capacity building; global intelligence; strategic communications and technology commercialization. EnergyINet's objective is develop energy resources that reduce dependence of fossil fuels while better utilizing existing energy sources to reduce greenhouse gas emissions. The strategy is to catalyze research and development to achieve an effective and environmentally suitable mix or alternate and renewable energy technologies. This presentation included graphs depicting Canadian energy sector growth from 1985 to the present; conversion of the Canadian economy to impure hydrogen for heating and transportation; an impure hydrogen value hierarchy; impure hydrogen implementation; and, hydrogen option examples such as wind electric power, hydrogen by electrolysis, electric power generation by hydrocarbon gasification, and distributed power generation with combined heat and power. It was noted that regulations and infrastructure are the key challenges facing hydrogen technology options in terms of production, transportation and applications. The action plan is to expand the

  19. Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

    Directory of Open Access Journals (Sweden)

    Mirza MU

    2015-03-01

    Full Text Available Muhammad Usman Mirza,1 Noor-Ul-Huda Ghori,2 Nazia Ikram,3 Abdur Rehman Adil,4 Sadia Manzoor3 1Centre for Research in Molecular Medicine (CRiMM, The University of Lahore, Lahore, 2Atta-ur-Rehman School of Applied Biosciences (ASAB, National University of Science and Technology, Islamabad, 3Institute of Molecular Biology and Biotechnology (IMBB, The University of Lahore, Lahore, Pakistan; 4Centre for Excellence in Molecular Biology (CEMB, The University of Punjab, Lahore, Pakistan Abstract: Hepatitis C virus (HCV is one of the major viruses affecting the world today. It is a highly variable virus, having a rapid reproduction and evolution rate. The variability of genomes is due to hasty replication catalyzed by nonstructural protein 5B (NS5B which is also a potential target site for the development of anti-HCV agents. Recently, the US Food and Drug Administration approved sofosbuvir as a novel oral NS5B inhibitor for the treatment of HCV. Unfortunately, it is much highlighted for its pricing issues. Hence, there is an urgent need to scrutinize alternate therapies against HCV that are available at affordable price and do not have associated side effects. Such a need is crucial especially in underdeveloped countries. The search for various new bioactive compounds from plants is a key part of pharmaceutical research. In the current study, we applied a pharmacoinformatics-based approach for the identification of active plant-derived compounds against NS5B. The results were compared to docking results of sofosbuvir. The lead compounds with high-binding ligands were further analyzed for pharmacokinetic and pharmacodynamic parameters based on in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET profile. The results showed the potential alternative lead compounds that can be developed into commercial drugs having high binding energy and promising ADMET properties. Keywords: hepatitis C, NS5B inhibitors, molecular docking, Auto

  20. Final programmatic environmental impact statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 2: Appendices

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky, Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. DOE's preferred alternative is to begin conversion of the depleted UF6 inventory as soon as possible, either to uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible. This volume contains Appendices A--O

  1. Lifeline electric rates and alternative approaches to the problems of low-income ratepayers: ten case studies of rejected programs

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    This volume, Volume 3, contains ten case studies of non-implemented programs. It is noted that in Volume 2, the implemented lifeline programs, evolved as policy closely after the 1973 oil embargo; in contrast, the rejected programs were initiated about 4 years later and considered in a more-complex policy environment - after which time alternate methods of assisting low-income people had been developed. Specifically presented here are program summary, issue development, governmental process, and impact for the following: (a) Delaware Senate Bill 202; (b) Illinois House Bill 83; (c) Maine Legislative Document No. 1043; (d) Minnesota House File 1243; (e) New York Assembly Bill 12214; (f) New York Senate Bill 7013-A; (g) Rhode Island Resolution 79-H 5770-A; (h) South Dakota Senate Joint Resolution 9; (i) West Virginia House Bill 943; and (j) Wisconsin Assembly Bill 1250. 4 figures, 24 tables.

  2. A New Volume-Based Approach for Predicting Thermophysical Behavior of Ionic Liquids and Ionic Liquid Crystals.

    Science.gov (United States)

    Nelyubina, Yulia V; Shaplov, Alexander S; Lozinskaya, Elena I; Buzin, Mikhail I; Vygodskii, Yakov S

    2016-08-17

    Volume-based prediction of melting points and other properties of ionic liquids (ILs) relies on empirical relations with volumes of ions in these low-melting organic salts. Here we report an accurate way to ionic volumes by Bader's partitioning of electron densities from X-ray diffraction obtained via a simple database approach. For a series of 1-tetradecyl-3-methylimidazolium salts, the volumes of different anions are found to correlate linearly with melting points; larger anions giving lower-melting ILs. The volume-based concept is transferred to ionic liquid crystals (ILs that adopt liquid crystalline mesophases, ILCs) for predicting the domain of their existence from the knowledge of their constituents. For 1-alkyl-3-methylimidazolium ILCs, linear correlations of ionic volumes with the occurrence of LC mesophase and its stability are revealed, thus paving the way to rational design of ILCs by combining suitably sized ions. PMID:27479022

  3. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 5. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume V of the five-volume report consists of appendices, which provide supplementary information, with emphasis on characteristics of geologic formations that might be used for final storage or disposal. Appendix titles are: selected glossary; conversion factors; geologic isolation, including, (a) site selection factors for repositories of wastes in geologic media, (b) rock types--geologic occurrence, (c) glossary of geohydrologic terms, and (d) 217 references; the ocean floor; and, government regulations pertaining to the management of radioactive materials. (JGB)

  4. The study of wear behaviors on abducted hip joint prostheses by an alternate finite element approach.

    Science.gov (United States)

    Lin, Yi-Tsung; Wu, James Shih-Shyn; Chen, Jian-Horng

    2016-07-01

    An acetabular cup with larger abduction angles is able to affect the normal function of the cup seriously that may cause early failure of the total hip replacement (THR). Complexity of the finite element (FE) simulation in the wear analysis of the THR is usually concerned with the contact status, the computational effort, and the possible divergence of results, which become more difficult on THRs with larger cup abduction angles. In the study, we propose a FE approach with contact transformation that offers less computational effort. Related procedures, such as Lagrangian Multiplier, partitioned matrix inversion, detection of contact forces, continuity of contact surface, nodal area estimation, etc. are explained in this report. Through the transformed methodology, the computer round-off error is tremendously reduced and the embedded repetitive procedure can be processed precisely and quickly. Here, wear behaviors of THR with various abduction angles are investigated. The most commonly used combination, i.e., metal-on-polyethylene, is adopted in the current study where a cobalt-chromium femoral head is paired with an Ultra High Molecular Weight Polyethylene (UHMWPE) cup. In all illustrations, wear coefficients are estimated by self-averaging strategy with available experimental datum reported elsewhere. The results reveal that the THR with larger abduction angles may produce deeper depth of wear but the volume of wear presents an opposite tendency; these results are comparable with clinical and experimental reports. The current approach can be widely applied easily to fields such as the study of the wear behaviors on ante-version, impingement, and time-dependent behaviors of prostheses etc. PMID:27265055

  5. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    This assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improving the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness. The objectives of this assessment are to identify when economic incentives to deploy advanced nuclear power systems might exist, to estimate the costs of using technologies that would reduce the risk of proliferation, to assess the impact of major economic uncertainties on the transition to new technologies, and to compare the investments required for alternative systems. This information can then be used to assess the potential economic benefits of alternative research, development, and demonstration programs and the timing of those programs

  6. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 1. Summary: alternatives for the back of the LWR fuel cycle types and properties of LWR fuel cycle wastes projections of waste quantities; selected glossary

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume I of the five-volume report contains executive and technical summaries of the entire report, background information of the LWR fuel cycle alternatives, descriptions of waste types, and projections of waste quantities. Overview characterizations of alternative LWR fuel cycle modes are also included. (JGB)

  7. Transradial artery intervention: an alternative approach for renal artery stent implantation?

    Institute of Scientific and Technical Information of China (English)

    LUO Jian-fang; WANG Hui-yong; HUANG Wen-hui; LIU Yuan; LI Guang; ZHOU Ying-ling; CHEN Ji-yan

    2012-01-01

    Background Transfemoral artery access is the main approach for the interventional treatment of renal artery stenosis (RAS).This study aimed to investigate the technical feasibility of a transradial interventional (TRI) treatment of renal artery stenosis.Methods A series of 23 patients who underwent transradial renal artery stenting from October 2010 to October 2011 were studied.Radial sheath system (Terumo,Japan) was used to get access to the radial artery.Radial tourniquet (Terumo) was used to stop bleeding.A 5Fr MPA (COOK,USA) was used to perform selective renal arteriography.Percutaneous renal artery stent systems were used to perform renal artery stenting.Results Renal artery angiography showed that 15 patients had unilateral renal artery stenosis and eight patients had bilateral renal artery stenosis.The descending aorta could not be catheterized in one patient because of the type Ⅲ aortic arch.Twenty-two patients successfully underwent transradial renal artery angiography and the technical success rate was 95.7%.There was no puncture site hematoma or pseudoaneurysm.Mean procedure time was (38.4±7.2) minutes,the mean amount of contrast agent used was (93.2±6.3) ml,and the mean postprocedure bleeding time was (3.2±1.9) minutes.Conclusion Transradial renal artery intervention is technically reliable with less invasion,rapid recovery,fewer complications and may become an alternative intervention approach for the treatment of renal artery stenosis.

  8. Covert video surveillance of parents suspected of child abuse: the British experience and alternative approaches.

    Science.gov (United States)

    Bauer, Keith A

    2004-01-01

    One million cases of child maltreatment and twelve hundred child deaths due to abuse and neglect occur per year. But since many cases of abuse and neglect remain either unreported or unsubstantiated due to insufficient evidence, the number of children who are abused, neglected, and killed at the hands of family caregivers is probably higher. One approach to combat child abuse in the U.K. has been the employment of hospital-based covert video surveillance (CVS) to monitor parents suspected of Munchausen Syndrome by Proxy (MSBP). The use of CVS, however, raises concerns about voluntary informed consent, research on human subjects, privacy, and the appropriateness of healthcare providers to conduct CVS. More broadly, the use of CVS raises concerns about the ethical life of healthcare institutions and their moral obligations to the families and communities they serve. The U.K. protocol for CVS is examined in light of these concerns. Three alternative CVS protocols and two procedures for selecting a protocol are then proposed for use in the U.S. The paper concludes that any CVS protocol selected for use by hospitals ought to be selected by means of open and democratic processes that permit community input and, subsequently, the possibility of a consensus on the moral status and scope of CVS.

  9. Alternative technological approach for synthesis of ceramic pigments by waste materials recycling

    Energy Technology Data Exchange (ETDEWEB)

    Doynov, M.; Dimitrov, T.; Kozhukharov, S.

    2016-05-01

    Alternative technological approach is proposed enabling utilization of raw materials from an oil refinery, such as waste guard layers from reactors. Reagent grade and purified MgO, Cr{sub 2}O{sub 3}, Fe{sub 2}O{sub 3}, and nitric acid (HNO{sub 3}), were used as additional precursors. The homogeneous mixtures obtained were formed into pellets and sintered at different temperatures. The main phase was proved by X-ray phase analysis (XRD) and compared to ICPDS database. The main phase in the ceramics synthesized was solid solution of spinel MgAl{sub 2}O{sub 4} and magnesiochromite. These minerals are classified as chromspinelide MgCr{sub 1}.2Al{sub 0}.4Fe{sub 0}.4O{sub 4} and alumochromite MgCr{sub 1}.6Al{sub 0}.4O{sub 4}. Additional SEM observations, combined with EDX analysis were performed, evincing agglomeration at lower temperatures, followed by agglomerate crumbling, at elevated calcination temperature. The complete transformation of initial precursors into the final ceramic compounds was found to occur at 800 degree centigrade 1 h. The ceramic samples synthesized had high density of 1.72-1.93 g/cm{sup 3} and large absorption area - 32.93% which is probably due to the high porosity of the sample. (Author)

  10. Model‐Based Assessment of Alternative Study Designs in Pediatric Trials. Part II: Bayesian Approaches

    Science.gov (United States)

    Smania, G; Baiardi, P; Ceci, A; Magni, P

    2016-01-01

    This study presents a pharmacokinetic‐pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed‐sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non‐hierarchical (NON‐H) and a semi‐hierarchical (SEMI‐H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of response to treatment between the pediatric and adult populations. Study designs were evaluated in terms of: type I and II errors, sample size per arm (SS), trial duration (TD), and estimate precision. No substantial differences were observed between NON‐H and SEMI‐H. BSDs require, on average, smaller SS and TD compared to the BD, which, on the other hand, guarantees higher estimate precision. When large differences between children and adults are expected, BSDs can return very large SS. Bayesian approaches appear to outperform their frequentist counterparts in the design of pediatric trials even when little weight is given to prior information from adults. PMID:27530374

  11. AN ALTERNATIVE APPROACH TO MEET BEEF SELF-SUFFICIENCY IN WEST PAPUA

    Directory of Open Access Journals (Sweden)

    S. Hartono

    2011-09-01

    Full Text Available The main objective of this research is to present an alternative approach to meet beef self-sufficiency in West Papua, Indonesia. It mainly focuses on calculating the needed number of productive cows to enhance beef production in the province. Out of the total farmer households in Manokwari, Indonesia, 189 farmer-respondents were selected as samples of the study. Selection of the sample was based on the number of cattle kept in every age group (less than one (2 years old and the number of productive cows. Secondary data came from the time series data of the number of slaughtered cattle vis-à-vis the population of all districts in West Papua Province from 1980-2008. Data were analyzed using the Partial Adjustment Model (PAM and Ordinary Least Square (OLS method. Results of the study showed that beef self-sufficiency in West Papua depend on the availability of the number of productive cows to produce ready-slaughtered-bull in the previous year. Particularly for West Papua, to produce one unit of bull in the tth –year, with the assumption that cattle mortality is 4.92%, a number of 2.38 animal units AU of productive cows must be provided in the previous two (2 years.

  12. Acute toxicity testing of chemicals-Opportunities to avoid redundant testing and use alternative approaches.

    Science.gov (United States)

    Creton, Stuart; Dewhurst, Ian C; Earl, Lesley K; Gehen, Sean C; Guest, Robert L; Hotchkiss, Jon A; Indans, Ian; Woolhiser, Michael R; Billington, Richard

    2010-01-01

    Assessment of the acute systemic oral, dermal, and inhalation toxicities, skin and eye irritancy, and skin sensitisation potential of chemicals is required under regulatory schemes worldwide. In vivo studies conducted to assess these endpoints can sometimes be associated with substantial adverse effects in the test animals, and their use should always be scientifically justified. It has been argued that while information obtained from such acute tests provides data needed to meet classification and labelling regulations, it is of limited value for hazard and risk assessments. Inconsistent application of in vitro replacements, protocol requirements across regions, and bridging principles also contribute to unnecessary and redundant animal testing. Assessment of data from acute oral and dermal toxicity testing demonstrates that acute dermal testing rarely provides value for hazard assessment purposes when an acute oral study has been conducted. Options to waive requirements for acute oral and inhalation toxicity testing should be employed to avoid unnecessary in vivo studies. In vitro irritation models should receive wider adoption and be used to meet regulatory needs. Global requirements for sensitisation testing need continued harmonisation for both substance and mixture assessments. This paper highlights where alternative approaches or elimination of tests can reduce and refine animal use for acute toxicity requirements. PMID:20144136

  13. An alternative approach to modeling genetic merit of feed efficiency in dairy cattle.

    Science.gov (United States)

    Lu, Y; Vandehaar, M J; Spurlock, D M; Weigel, K A; Armentano, L E; Staples, C R; Connor, E E; Wang, Z; Bello, N M; Tempelman, R J

    2015-09-01

    Genetic improvement of feed efficiency (FE) in dairy cattle requires greater attention given increasingly important resource constraint issues. A widely accepted yet occasionally contested measure of FE in dairy cattle is residual feed intake (RFI). The use of RFI is limiting for several reasons, including interpretation, differences in recording frequencies between the various component traits that define RFI, and potential differences in genetic versus nongenetic relationships between dry matter intake (DMI) and FE component traits. Hence, analyses focusing on DMI as the response are often preferred. We propose an alternative multiple-trait (MT) modeling strategy that exploits the Cholesky decomposition to provide a potentially more robust measure of FE. We demonstrate that our proposed FE measure is identical to RFI provided that genetic and nongenetic relationships between DMI and component traits of FE are identical. We assessed both approaches (MT and RFI) by simulation as well as by application to 26,383 weekly records from 50 to 200 d in milk on 2,470 cows from a dairy FE consortium study involving 7 institutions. Although the proposed MT model fared better than the RFI model when simulated genetic and nongenetic associations between DMI and FE component traits were substantially different from each other, no meaningful differences were found in predictive performance between the 2 models when applied to the consortium data. PMID:26210274

  14. An alternative approach to measure similarity between two deterministic transient signals

    Science.gov (United States)

    Shin, Kihong

    2016-06-01

    In many practical engineering applications, it is often required to measure the similarity of two signals to gain insight into the conditions of a system. For example, an application that monitors machinery can regularly measure the signal of the vibration and compare it to a healthy reference signal in order to monitor whether or not any fault symptom is developing. Also in modal analysis, a frequency response function (FRF) from a finite element model (FEM) is often compared with an FRF from experimental modal analysis. Many different similarity measures are applicable in such cases, and correlation-based similarity measures may be most frequently used among these such as in the case where the correlation coefficient in the time domain and the frequency response assurance criterion (FRAC) in the frequency domain are used. Although correlation-based similarity measures may be particularly useful for random signals because they are based on probability and statistics, we frequently deal with signals that are largely deterministic and transient. Thus, it may be useful to develop another similarity measure that takes the characteristics of the deterministic transient signal properly into account. In this paper, an alternative approach to measure the similarity between two deterministic transient signals is proposed. This newly proposed similarity measure is based on the fictitious system frequency response function, and it consists of the magnitude similarity and the shape similarity. Finally, a few examples are presented to demonstrate the use of the proposed similarity measure.

  15. Alternative approach in 3D MEMS-IC integration using fluidic self-assembly techniques

    International Nuclear Information System (INIS)

    Nowadays, industries are investigating new, original and appropriate solutions to address challenges in 3D MEMS-IC large-scale integration. Self-assembly techniques are among those. We report on an alternative approach inspired from fluidic self-assembly and using the flip-chip method. Here, solder bumps are directly formed onto a MEMS chip using liquid solder solution in a bath. The self-alignment process is operated after surface treatment by plasma deposition to form high and low wettability selective patterns. Finally, MEMS and electronic chips are permanently bonded after low thermal heating without any pressure. Electrical contact is established and electromechanisms of the microsystems are proven. Compared to classic MEMS-IC flip-chip methods, this strategy presents many advantages: it is a low-cost and fast fabrication process requiring no specific equipment for deposition of solder bumps. Furthermore, it can be applied on different substrates and it does not require a specific pressure method during the bonding process. This strategy is also an appropriate fabrication method for large-scale MEMS integration where electronic connection density is high

  16. Alternative Approaches in Evaluating the EU SME Policy: Answers to the Question of Impact and Legitimization

    Directory of Open Access Journals (Sweden)

    Robert K. GRUENWALD

    2014-08-01

    Findings:  OECD  and  EU  evaluations  do  not  determine  causal  relationships  between funding allocation and effects. The evaluations of the KfW and the German Ministry of Economics  use  an  empirical  quantitative  approach  and  determine  direct  causal relations. In  order to fulfil the requirements of legitimizing functions  for  the  SME  policy,  it  is  recommended  to  further  develop  the  EU  funding policy  and  evaluation  according  to  the  “German  model”  both  in  terms  of  the institutional  framework  and  in  terms  of  the  evaluation  of  impacts  through  funding policy measures. Definition  of  minimum  requirements  and  alternative possibilities  for  EU  SME  policy  evaluation  in  order  to  close  the  legitimisation  gap between the allocation of tax money and impact proof (cost-benefit ratio.

  17. A pyramid-based approach to visual exploration of a large volume of vehicle trajectory data

    Institute of Scientific and Technical Information of China (English)

    Jing SUN; Xiang LI

    2012-01-01

    Advances in positioning and wireless communicating technologies make it possible to collect large volumes of trajectory data of moving vehicles in a fast and convenient fashion.These data can be applied to traffic studies.Behind this application,a methodological issue that still requires particular attention is the way these data should be spatially visualized.Trajectory data physically consists of a large number of positioning points.With the dramatic increase of data volume,it becomes a challenge to display and explore these data.Existing commercial software often employs vector-based indexing structures to facilitate the display of a large volume of points,but their performance downgrades quickly when the number of points is very large,for example,tens of millions.In this paper,a pyramid-based approach is proposed.A pyramid method initially is invented to facilitate the display of raster images through the tradeoff between storage space and display time.A pyramid is a set of images at different levels with different resolutions.In this paper,we convert vector-based point data into raster data,and build a gridbased indexing structure in a 2D plane.Then,an image pyramid is built.Moreover,at the same level of a pyramid,image is segmented into mosaics with respect to the requirements of data storage and management.Algorithms or procedures on grid-based indexing structure,image pyramid,image segmentation,and visualization operations are given in this paper.A case study with taxi trajectory data in Shanghai is conducted.Results demonstrate that the proposed method outperforms the existing commercial software.

  18. NUMERICAL SIMULATION OF ELECTRICAL IMPEDANCE TOMOGRAPHY PROBLEM AND STUDY OF APPROACH BASED ON FINITE VOLUME METHOD

    Directory of Open Access Journals (Sweden)

    Ye. S. Sherina

    2014-01-01

    Full Text Available This research has been aimed to carry out a study of peculiarities that arise in a numerical simulation of the electrical impedance tomography (EIT problem. Static EIT image reconstruction is sensitive to a measurement noise and approximation error. A special consideration has been given to reducing of the approximation error, which originates from numerical implementation drawbacks. This paper presents in detail two numerical approaches for solving EIT forward problem. The finite volume method (FVM on unstructured triangular mesh is introduced. In order to compare this approach, the finite element (FEM based forward solver was implemented, which has gained the most popularity among researchers. The calculated potential distribution with the assumed initial conductivity distribution has been compared to the analytical solution of a test Neumann boundary problem and to the results of problem simulation by means of ANSYS FLUENT commercial software. Two approaches to linearized EIT image reconstruction are discussed. Reconstruction of the conductivity distribution is an ill-posed problem, typically requiring a large amount of computation and resolved by minimization techniques. The objective function to be minimized is constructed of measured voltage and calculated boundary voltage on the electrodes. A classical modified Newton type iterative method and the stochastic differential evolution method are employed. A software package has been developed for the problem under investigation. Numerical tests were conducted on simulated data. The obtained results could be helpful to researches tackling the hardware and software issues for medical applications of EIT.

  19. Study on Macroscopic and Microscopic Mechanical Behavior of Magnetorheological Elastomers by Representative Volume Element Approach

    Directory of Open Access Journals (Sweden)

    Shulei Sun

    2014-01-01

    Full Text Available By using a representative volume element (RVE approach, this paper investigates the effective mechanical properties of anisotropic magnetorheological elastomers (MREs in which particles are aligned and form chain-like structure under magnetic field during curing. Firstly, a three-dimensional RVE in zero magnetic field is presented in ABAQUS/Standard to calculate the macroscopic mechanical properties of MREs. It is shown that the initial shear modulus of MREs increases by 56% with a 20% volume fraction of particles compared to that of pure rubber. Then by introducing the Maxwell stress tensor, a two-dimensional plane stress RVE for the MRE is developed in COMSOL Multiphysics to study its response under a magnetic field. The influences of magnetic field intensity, radius of particles, and distance between two adjacent particles on the macroscopic mechanical properties of MRE are also investigated. The results show that the shear modulus increases with the increase of the applied magnetic field intensity and the radius of particles and the decrease of the distance between two adjacent particles in a chain. The predicted numerical results are consistent with theoretical results from Mori-Tanaka model, double inclusion model, and dipole model.

  20. VOXEL-BASED APPROACH FOR ESTIMATING URBAN TREE VOLUME FROM TERRESTRIAL LASER SCANNING DATA

    Directory of Open Access Journals (Sweden)

    C. Vonderach

    2012-07-01

    Full Text Available The importance of single trees and the determination of related parameters has been recognized in recent years, e.g. for forest inventories or management. For urban areas an increasing interest in the data acquisition of trees can be observed concerning aspects like urban climate, CO2 balance, and environmental protection. Urban trees differ significantly from natural systems with regard to the site conditions (e.g. technogenic soils, contaminants, lower groundwater level, regular disturbance, climate (increased temperature, reduced humidity and species composition and arrangement (habitus and health status and therefore allometric relations cannot be transferred from natural sites to urban areas. To overcome this problem an extended approach was developed for a fast and non-destructive extraction of branch volume, DBH (diameter at breast height and height of single trees from point clouds of terrestrial laser scanning (TLS. For data acquisition, the trees were scanned with highest scan resolution from several (up to five positions located around the tree. The resulting point clouds (20 to 60 million points are analysed with an algorithm based on voxel (volume elements structure, leading to an appropriate data reduction. In a first step, two kinds of noise reduction are carried out: the elimination of isolated voxels as well as voxels with marginal point density. To obtain correct volume estimates, the voxels inside the stem and branches (interior voxels where voxels contain no laser points must be regarded. For this filling process, an easy and robust approach was developed based on a layer-wise (horizontal layers of the voxel structure intersection of four orthogonal viewing directions. However, this procedure also generates several erroneous "phantom" voxels, which have to be eliminated. For this purpose the previous approach was extended by a special region growing algorithm. In a final step the volume is determined layer-wise based on the

  1. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities.

  2. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    International Nuclear Information System (INIS)

    The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities

  3. Alternations in plasma volume and protein during and after a continuous 110-kilometer march with 20-kilogram backpack load.

    Science.gov (United States)

    Ashkenazi, I; Epshtein, Y

    1998-10-01

    The purpose of this study was to determine the effect of a continuous 110-km march with a 20-kg backpack load on plasma volume and intravascular protein content. Twenty-two healthy male volunteers, aged 19 to 20 years (mean, 19.4 years), physically conditioned for continuous strenuous exercise, with a mean (+/- SD) maximal oxygen consumption of 59.1 (+/- 7.9) ml/kg/min, participated in the study. The march was performed under ambient conditions of 17 to 32 degrees C dry temperature and 45 to 85% relative humidity. Venous blood samples were obtained before, during, and after the march. The average calculated oxygen consumption during the march was about 30% of maximal oxygen consumption. Mean body weight loss was 3.4% of the premarch weight, mean water ingestion was 14,250 ml, and mean urine volume was 2,687 ml. Relative changes of plasma volume and total content of plasma protein were calculated from hematocrit ratio and hemoglobin concentration. A significant reduction (-6.1 +/- 1.7%, mean +/- SE) in plasma volume and a minimal elevation in intravascular protein content (1.6 +/- 2.5%) were observed during the march. During the first 24 hours of recovery, plasma volume was further reduced (-8.4 +/- 1.8%), with a significant reduction in protein content (-6.6 +/- 1.8%), mainly albumin (-9.3 +/- 1.7%). During the second day of recovery, peak elevations in plasma volume (3.7 +/- 1.4%) and protein content (6.0 +/- 1.6%) were observed. The changes in protein content were related to elevations in albumin (3.7 +/- 1.3%) and globulin (10.7 +/- 3.2%) content. The elevated plasma volume and protein content were also maintained 96 hours after the end of the march. Although the changes in plasma volume during the march were associated with changes in serum albumin and globulin content, during the recovery period there was association only with the changes in serum globulin content. The possible mechanism of these findings is discussed.

  4. Characterization of alternative electric generation technologies for the SPS comparative assessment: volume 2, central-station technologies

    International Nuclear Information System (INIS)

    The SPS Concept Development and Evaluation Program includes a comparative assessment. An early first step in the assessment process is the selection and characterization of alternative technologies. This document describes the cost and performance (i.e., technical and environmental) characteristics of six central station energy alternatives: (1) conventional coal-fired powerplant; (2) conventional light water reactor (LWR); (3) combined cycle powerplant with low-Btu gasifiers; (4) liquid metal fast breeder reactor (LMFBR); (5) photovoltaic system without storage; and (6) fusion reactor

  5. Characterization of alternative electric generation technologies for the SPS comparative assessment: volume 2, central-station technologies

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    The SPS Concept Development and Evaluation Program includes a comparative assessment. An early first step in the assessment process is the selection and characterization of alternative technologies. This document describes the cost and performance (i.e., technical and environmental) characteristics of six central station energy alternatives: (1) conventional coal-fired powerplant; (2) conventional light water reactor (LWR); (3) combined cycle powerplant with low-Btu gasifiers; (4) liquid metal fast breeder reactor (LMFBR); (5) photovoltaic system without storage; and (6) fusion reactor.

  6. Traditional, complementary, and alternative medicine approaches to mental health care and psychological wellbeing in India and China.

    Science.gov (United States)

    Thirthalli, Jagadisha; Zhou, Liang; Kumar, Kishore; Gao, Jie; Vaid, Henna; Liu, Huiming; Hankey, Alex; Wang, Guojun; Gangadhar, Bangalore N; Nie, Jing-Bao; Nichter, Mark

    2016-07-01

    India and China face the same challenge of having too few trained psychiatric personnel to manage effectively the substantial burden of mental illness within their population. At the same time, both countries have many practitioners of traditional, complementary, and alternative medicine who are a potential resource for delivery of mental health care. In our paper, part of The Lancet and Lancet Psychiatry's Series about the China-India Mental Health Alliance, we describe and compare types of traditional, complementary, and alternative medicine in India and China. Further, we provide a systematic overview of evidence assessing the effectiveness of these alternative approaches for mental illness and discuss challenges in research. We suggest how practitioners of traditional, complementary, and alternative medicine and mental health professionals might forge collaborative relationships to provide more accessible, affordable, and acceptable mental health care in India and China. A substantial proportion of individuals with mental illness use traditional, complementary, and alternative medicine, either exclusively or with biomedicine, for reasons ranging from faith and cultural congruence to accessibility, cost, and belief that these approaches are safe. Systematic reviews of the effectiveness of traditional, complementary, and alternative medicine find several approaches to be promising for treatment of mental illness, but most clinical trials included in these systematic reviews have methodological limitations. Contemporary methods to establish efficacy and safety-typically through randomised controlled trials-need to be complemented by other means. The community of practice built on collaborative relationships between practitioners of traditional, complementary, and alternative medicine and providers of mental health care holds promise in bridging the treatment gap in mental health care in India and China. PMID:27209157

  7. Traditional, complementary, and alternative medicine approaches to mental health care and psychological wellbeing in India and China.

    Science.gov (United States)

    Thirthalli, Jagadisha; Zhou, Liang; Kumar, Kishore; Gao, Jie; Vaid, Henna; Liu, Huiming; Hankey, Alex; Wang, Guojun; Gangadhar, Bangalore N; Nie, Jing-Bao; Nichter, Mark

    2016-07-01

    India and China face the same challenge of having too few trained psychiatric personnel to manage effectively the substantial burden of mental illness within their population. At the same time, both countries have many practitioners of traditional, complementary, and alternative medicine who are a potential resource for delivery of mental health care. In our paper, part of The Lancet and Lancet Psychiatry's Series about the China-India Mental Health Alliance, we describe and compare types of traditional, complementary, and alternative medicine in India and China. Further, we provide a systematic overview of evidence assessing the effectiveness of these alternative approaches for mental illness and discuss challenges in research. We suggest how practitioners of traditional, complementary, and alternative medicine and mental health professionals might forge collaborative relationships to provide more accessible, affordable, and acceptable mental health care in India and China. A substantial proportion of individuals with mental illness use traditional, complementary, and alternative medicine, either exclusively or with biomedicine, for reasons ranging from faith and cultural congruence to accessibility, cost, and belief that these approaches are safe. Systematic reviews of the effectiveness of traditional, complementary, and alternative medicine find several approaches to be promising for treatment of mental illness, but most clinical trials included in these systematic reviews have methodological limitations. Contemporary methods to establish efficacy and safety-typically through randomised controlled trials-need to be complemented by other means. The community of practice built on collaborative relationships between practitioners of traditional, complementary, and alternative medicine and providers of mental health care holds promise in bridging the treatment gap in mental health care in India and China.

  8. The Science and Technology Pre-Service Teachers' Self-Efficacy Levels and Opinions about Alternative Assessment and Evaluation Approaches

    Science.gov (United States)

    Sasmaz Oren, Fatma; Ormanci, Ummuhan; Evrekli, Ertug

    2011-01-01

    The present study aims to determine the science and technology pre-service teachers' self-efficacy levels and their opinions about alternative assessment and evaluation approaches. The study was carried out with the participation of 53 science and technology pre-service teachers studying in the Faculty of Education at Celal Bayar University. As…

  9. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    Science.gov (United States)

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  10. Merging Alternate Remotely-Sensed Soil Moisture Retrievals Using a Non-Static Model Combination Approach

    Directory of Open Access Journals (Sweden)

    Seokhyeon Kim

    2016-06-01

    Full Text Available Soil moisture is an important variable in the coupled hydrologic and climate system. In recent years, microwave-based soil moisture products have been shown to be a viable alternative to in situ measurements. A popular way to measure the performance of soil moisture products is to calculate the temporal correlation coefficient (R against in situ measurements or other appropriate reference datasets. In this study, an existing linear combination method improving R was modified to allow for a non-static or nonstationary model combination as the basis for improving remotely-sensed surface soil moisture. Previous research had noted that two soil moisture products retrieved using the Japan Aerospace Exploration Agency (JAXA and Land Parameter Retrieval Model (LPRM algorithms from the same Advanced Microwave Scanning Radiometer 2 (AMSR2 sensor are spatially complementary in terms of R against a suitable reference over a fixed period. Accordingly, a linear combination was proposed to maximize R using a set of spatially-varying, but temporally-fixed weights. Even though this approach showed promising results, there was room for further improvements, in particular using non-static or dynamic weights that take account of the time-varying nature of the combination algorithm being approximated. The dynamic weighting was achieved by using a moving window. A number of different window sizes was investigated. The optimal weighting factors were determined for the data lying within the moving window and then used to dynamically combine the two parent products. We show improved performance for the dynamically-combined product over the static linear combination. Generally, shorter time windows outperform the static approach, and a 60-day time window is suggested to be the optimum. Results were validated against in situ measurements collected from 124 stations over different continents. The mean R of the dynamically-combined products was found to be 0.57 and 0

  11. New approach to the perception of 3D shape based on veridicality, complexity, symmetry and volume.

    Science.gov (United States)

    Pizlo, Zygmunt; Sawada, Tadamasa; Li, Yunfeng; Kropatsch, Walter G; Steinman, Robert M

    2010-01-01

    This paper reviews recent progress towards understanding 3D shape perception made possible by appreciating the significant role that veridicality and complexity play in the natural visual environment. The ability to see objects as they really are "out there" is derived from the complexity inherent in the 3D object's shape. The importance of both veridicality and complexity was ignored in most prior research. Appreciating their importance made it possible to devise a computational model that recovers the 3D shape of an object from only one of its 2D images. This model uses a simplicity principle consisting of only four a priori constraints representing properties of 3D shapes, primarily their symmetry and volume. The model recovers 3D shapes from a single 2D image as well, and sometimes even better, than a human being. In the rare recoveries in which errors are observed, the errors made by the model and human subjects are very similar. The model makes no use of depth, surfaces or learning. Recent elaborations of this model include: (i) the recovery of the shapes of natural objects, including human and animal bodies with limbs in varying positions (ii) providing the model with two input images that allowed it to achieve virtually perfect shape constancy from almost all viewing directions. The review concludes with a comparison of some of the highlights of our novel, successful approach to the recovery of 3D shape from a 2D image with prior, less successful approaches. PMID:19800910

  12. Probing Aircraft Flight Test Hazard Mitigation for the Alternative Fuel Effects on Contrails and Cruise Emissions (ACCESS) Research Team . Volume 2; Appendices

    Science.gov (United States)

    Kelly, Michael J.

    2013-01-01

    The Alternative Fuel Effects on Contrails and Cruise Emissions (ACCESS) Project Integration Manager requested in July 2012 that the NASA Engineering and Safety Center (NESC) form a team to independently assess aircraft structural failure hazards associated with the ACCESS experiment and to identify potential flight test hazard mitigations to ensure flight safety. The ACCESS Project Integration Manager subsequently requested that the assessment scope be focused predominantly on structural failure risks to the aircraft empennage (horizontal and vertical tail). This report contains the Appendices to Volume I.

  13. Alternative approaches of SiC & related wide bandgap materials in light emitting & solar cell applications

    Science.gov (United States)

    Wellmann, Peter; Syväjärvi, Mikael; Ou, Haiyan

    2014-03-01

    Materials for optoelectronics give a fascinating variety of issues to consider. Increasingly important are white light emitting diode (LED) and solar cell materials. Profound energy savings can be done by addressing new materials. White light emitting diodes are becoming common in our lighting scene. There is a great energy saving in the transition from the light bulb to white light emitting diodes via a transition of fluorescent light tubes. However, the white LEDs still suffer from a variety of challenges in order to be in our daily use. Therefore there is a great interest in alternative lighting solutions that could be part of our daily life. All materials create challenges in fabrication. Defects reduce the efficiency of optical transitions involved in the light emitting diode materials. The donor-acceptor co-doped SiC is a potential light converter for a novel monolithic all-semiconductor white LED. In spite of considerable research, the internal quantum efficiency is far less than theoretically predicted and is likely a fascinating scientific field for studying materials growth, defects and optical transitions. Still, efficient Si-based light source represents an ongoing research field in photonics that requires high efficiency at room temperature, wavelength tuning in a wide wavelength range, and easy integration in silicon photonic devices. In some of these devices, rare earth doped materials is considered as a potential way to provide luminescence spanning in a wide wavelength range. Divalent and trivalent oxidation states of Eu provide emitting centers in the visible region. In consideration, the use of Eu in photonics requires Eu doped thin films that are compatible with CMOS technology but for example faces material science issues like a low Eu solid solubility in silica. Therefore approaches aim to obtain efficient light emission from silicon oxycarbide which has a luminescence in the visible range and can be a host material for rare earth ions. The

  14. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    International Nuclear Information System (INIS)

    Volume IV provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

  15. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-12-01

    Volume IV provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest.

  16. Mixed strategies for energy conservation and alternative energy utilization (solar) in buildings. Final report. Volume III. Appendixes. [10 appendices

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-06-01

    This appendix summarizes building characteristics used to determine heating and cooling loads for each of the five building types in each of the four regions. For the selected five buildings, the following data are attached: new and existing construction characteristics; new and existing construction thermal resistance; floor plan and elevation; people load schedule; lighting load schedule; appliance load schedule; ventilation schedule; and hot water use schedule. For the five building types (single family, apartment buildings, commercial buildings, office buildings, and schools), data are compiled in 10 appendices. These are Building Characteristics; Alternate Energy Sources and Energy Conservation Techniques Description, Costs, Fuel Price Scenarios; Life Cycle Cost Model; Simulation Models; Solar Heating/Cooling System; Condensed Weather; Single and Multi-Family Dwelling Characteristics and Energy Conservation Techniques; Mixed Strategies for Energy Conservation and Alternative Energy Utilization in Buildings. An extensive bibliography is given in the final appendix. (MCW)

  17. Impacts of Alternative Marketing Agreement Cattle Procurement Volumes on Packer Costs: Evidence from Plant-Level P&L Data

    OpenAIRE

    Koontz, Stephen R.; Muth, Mary K.; Lawrence, John D.

    2007-01-01

    It has been argued that access to captive supply cattle improve the economic efficiency of beef packing facilities. However, this argument has not been subject to hypothesis testing. This work models the cost efficiencies associated with captive supplies or cattle we refer to as being sourced through alternative marketing agreements (AMAs). We find that slaughter and processing costs are lower ceteris paribus for AMA cattle than for cash market cattle. We find that plants that slaughter cattl...

  18. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VIII. Advanced concepts

    International Nuclear Information System (INIS)

    The six advanced concepts for nuclear power systems that were selected for evaluation are: the fast mixed-spectrum reactor; the denatured molten-salt reactor; the mixed-flow gaseous-core reactor; the linear-accelerator fuel-regenerator reactor; the ternary metal-fueled electronuclear fuel-producer reactor; and the tokamak fusion-fission hybrid reactor. The design assessment was performed by identifying needs in six specific areas: conceptual plant design; reactor-physics considerations; fuel cycle alternatives; mechanical and thermal-hydraulic considerations; selection, development, and availability of materials; and engineering and operability. While none of the six concepts appears to be a credible commercial alternative to the liquid-metal fast-breeder within the Nonproliferation Alternative Systems Assessment Program horizon of 2025, there are a number of reasons for continued interest in the fast mixed-spectrum reactor: it is a once-through cycle fast reactor with proliferation risk characteristics similar to those of the light-water reactor; only about one-third as much uranium is required as for the once-through light-water reactor; the system will benefit directly from fast-breeder development programs; and, finally, the research and development required to develop the high-burnup metal fuel could benefit the on-going liquid-metal fast-breeder reactor program. Accordingly, a limited research and development effort on the high-burnup fuel seems justified, at present

  19. The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches

    International Nuclear Information System (INIS)

    The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling is complex and cost-intensive. Formalin-fixed paraffin-embedded specimens (FFPE) are easy to handle and economic to store, but their applicability for molecular methods is restricted. The recently introduced Hepes-glutamic acid-buffer mediated Organic solvent Protection Effect (HOPE) is a promising alternative, which might have the potential to unite the benefits of FFPE and fresh-frozen specimen. Aim of the study was to compare HOPE-fixed, FFPE and fresh-frozen bio-specimens for their accessibility for diagnostic and research purposes. 10 prostate cancer samples were each preserved with HOPE, formalin, and liquid nitrogen and studied with in-situ and molecular methods. Samples were H&E stained, and assessed by immunohistochemistry (i.e. PSA, GOLPH2, p63) and FISH (i.e. ERG rearrangement). We assessed DNA integrity by PCR, using control genes ranging from 100 to 600 bp amplicon size. RNA integrity was assessed through qRT-PCR on three housekeeping genes (TBP, GAPDH, β-actin). Protein expression was analysed by performing western blot analysis using GOLPH2 and PSA antibodies. Of the HOPE samples, morphologic quality of H&E sections, immunohistochemical staining, and the FISH assay was at least equal to FFPE tissue, and significantly better than the fresh-frozen specimens. DNA, RNA, and protein analysis of HOPE samples provided similar results as compared to fresh-frozen specimens. As expected, FFPE-samples were inferior for most of the molecular analyses. This is the first study, comparatively assessing the suitability of these fixation methods for diagnostic and research utilization. Overall, HOPE-fixed bio-specimens combine the benefits of FFPE- and fresh-frozen samples. Results of this study have the potential to expand on contemporary prostate tissue

  20. The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches

    Directory of Open Access Journals (Sweden)

    Braun Martin

    2011-12-01

    Full Text Available Abstract Background The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling is complex and cost-intensive. Formalin-fixed paraffin-embedded specimens (FFPE are easy to handle and economic to store, but their applicability for molecular methods is restricted. The recently introduced Hepes-glutamic acid-buffer mediated Organic solvent Protection Effect (HOPE is a promising alternative, which might have the potential to unite the benefits of FFPE and fresh-frozen specimen. Aim of the study was to compare HOPE-fixed, FFPE and fresh-frozen bio-specimens for their accessibility for diagnostic and research purposes. Methods 10 prostate cancer samples were each preserved with HOPE, formalin, and liquid nitrogen and studied with in-situ and molecular methods. Samples were H&E stained, and assessed by immunohistochemistry (i.e. PSA, GOLPH2, p63 and FISH (i.e. ERG rearrangement. We assessed DNA integrity by PCR, using control genes ranging from 100 to 600 bp amplicon size. RNA integrity was assessed through qRT-PCR on three housekeeping genes (TBP, GAPDH, β-actin. Protein expression was analysed by performing western blot analysis using GOLPH2 and PSA antibodies. Results Of the HOPE samples, morphologic quality of H&E sections, immunohistochemical staining, and the FISH assay was at least equal to FFPE tissue, and significantly better than the fresh-frozen specimens. DNA, RNA, and protein analysis of HOPE samples provided similar results as compared to fresh-frozen specimens. As expected, FFPE-samples were inferior for most of the molecular analyses. Conclusions This is the first study, comparatively assessing the suitability of these fixation methods for diagnostic and research utilization. Overall, HOPE-fixed bio-specimens combine the benefits of FFPE- and fresh-frozen samples. Results of this study

  1. An alternative approach to determine attainable resolution directly from HREM images

    International Nuclear Information System (INIS)

    The concept of resolution in high-resolution electron microscopy (HREM) is the power to resolve neighboring atoms. Since the resolution is related to the width of the point spread function of the microscope, it could in principle be determined from the image of a point object. However, in electron microscopy there are no ideal point objects. The smallest object is an individual atom. If the width of an atom is much smaller than the resolution of the microscope, this atom can still be considered as a point object. As the resolution of the microscope enters the sub-Å regime, information about the microscope is strongly entangled with the information about the atoms in HREM images. Therefore, we need to find an alternative method to determine the resolution in an object-independent way. In this work we propose to use the image wave of a crystalline object in zone axis orientation. Under this condition, the atoms of a column act as small lenses so that the electron beam channels through the atom column periodically. Because of this focusing, the image wave of the column can be much more peaked than the constituting atoms and can thus be a much more sensitive probe to measure the resolution. Our approach is to use the peakiness of the image wave of the atom column to determine the resolution. We will show that the resolution can be directly linked to the total curvature of the atom column wave. Moreover, we can then directly obtain the resolution of the microscope given that the contribution from the object is known, which is related to the bounding energy of the atom. The method is applied on an experimental CaTiO3 image wave. - Highlights: • Microscope aberrations and the size of the atoms influence the resolution at the sub-Å level. • In channeling condition the atoms in the column focus the electron beam into a narrow peak at the exit face. • The shape of this peak can be used to determine the resolution in an object independent way. • This results in a

  2. Ion Recognition Approach to Volume Reduction of Alkaline Tank Waste by Separation of Sodium Salts

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, Bruce A.; Bonnesen, Peter V.; Custelcean, Radu; Delmau, Laetitia H.; Engle, Nancy L.; Kang, Hyun-Ah; Keever, Tamara J.; Marchand, Alan P.; Gadthula, Srinivas; Gore, Vinayak K.; Huang, Zilin; Sivappa, Rasapalli; Tirunahari, Pavan K.; Levitskaia, Tatiana G.; Lumetta, Gregg J.

    2005-09-26

    The purpose of this research involving collaboration between Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL) is to explore new approaches to the separation of sodium hydroxide, sodium nitrate, and other sodium salts from high-level alkaline tank waste. The principal potential benefit is a major reduction in disposed waste volume, obviating the building of expensive new waste tanks and reducing the costs of vitrification. Principles of ion recognition are being researched toward discovery of liquid-liquid extraction systems that selectively separate sodium hydroxide and sodium nitrate from other waste components. The successful concept of pseudo hydroxide extraction using fluorinated alcohols and phenols is being developed at ORNL and PNNL toward a greater understanding of the controlling equilibria, role of solvation, and of synergistic effects involving crown ethers. Synthesis efforts are being directed toward enhanced sodium binding by crown ethers, both neutral and proton-ionizable. Studies with real tank waste at PNNL will provide feedback toward solvent compositions that have promising properties.

  3. A statistical approach to the initial volume problem in Single Particle Analysis by Electron Microscopy.

    Science.gov (United States)

    Sorzano, C O S; Vargas, J; de la Rosa-Trevín, J M; Otón, J; Álvarez-Cabrera, A L; Abrishami, V; Sesmero, E; Marabini, R; Carazo, J M

    2015-03-01

    Cryo Electron Microscopy is a powerful Structural Biology technique, allowing the elucidation of the three-dimensional structure of biological macromolecules. In particular, the structural study of purified macromolecules -often referred as Single Particle Analysis(SPA)- is normally performed through an iterative process that needs a first estimation of the three-dimensional structure that is progressively refined using experimental data. It is well-known the local optimisation nature of this refinement, so that the initial choice of this first structure may substantially change the final result. Computational algorithms aiming to providing this first structure already exist. However, the question is far from settled and more robust algorithms are still needed so that the refinement process can be performed with sufficient guarantees. In this article we present a new algorithm that addresses the initial volume problem in SPA by setting it in a Weighted Least Squares framework and calculating the weights through a statistical approach based on the cumulative density function of different image similarity measures. We show that the new algorithm is significantly more robust than other state-of-the-art algorithms currently in use in the field. The algorithm is available as part of the software suite Xmipp (http://xmipp.cnb.csic.es) and Scipion (http://scipion.cnb.csic.es) under the name "Significant".

  4. Final Technical Report for Alternative Fuel Source Study-An Energy Efficient and Environmentally Friendly Approach

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Ralph [Auburn University, AL (United States); Schindler, Anton [Auburn University, AL (United States); Duke, Steve [Auburn University, AL (United States); Burch, Thom [Auburn University, AL (United States); Bransby, David [Auburn University, AL (United States); Stafford, Don [Lafarge North America, Inc., Alpharetta, GA (United States)

    2010-08-31

    The objective of this project is to conduct research to determine the feasibility of using alternate fuel sources for the production of cement. Successful completion of this project will also be beneficial to other commercial processes that are highly energy intensive. During this report period, we have completed all the subtasks in the preliminary survey. Literature searches focused on the types of alternative fuels currently used in the cement industry around the world. Information was obtained on the effects of particular alternative fuels on the clinker/cement product and on cement plant emissions. Federal regulations involving use of waste fuels were examined. Information was also obtained about the trace elements likely to be found in alternative fuels, coal, and raw feeds, as well as the effects of various trace elements introduced into system at the feed or fuel stage on the kiln process, the clinker/cement product, and concrete made from the cement. The experimental part of this project involves the feasibility of a variety of alternative materials mainly commercial wastes to substitute for coal in an industrial cement kiln in Lafarge NA and validation of the experimental results with energy conversion consideration.

  5. Selection of process alternatives for lignocellulosic bioethanol production using a MILP approach.

    Science.gov (United States)

    Scott, Felipe; Venturini, Fabrizio; Aroca, Germán; Conejeros, Raúl

    2013-11-01

    This work proposes a decision-making framework for the selection of processes and unit operations for lignocellulosic bioethanol production. Process alternatives are described by its capital and operating expenditures, its contribution to process yield and technological availability information. A case study in second generation ethanol production using Eucalyptus globulus as raw material is presented to test the developed process synthesis tool. Results indicate that production cost does not necessarily decrease when yield increases. Hence, optimal processes can be found at the inflexion point of total costs and yield. The developed process synthesis tool provides results with an affordable computational cost, existing optimization tools and an easy-to-upgrade description of the process alternatives. These features made this tool suitable for process screening when incomplete information regarding process alternatives is available.

  6. A numerical-statistical approach to determining the representative elementary volume (REV) of cement paste for measuring diffusivity

    OpenAIRE

    Zhang, M. Z.; Ye, G.; van Breugel, K

    2010-01-01

    Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV), in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First,...

  7. Final programmatic environmental impact statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 3: Responses to public comments

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky, Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. DOE's preferred alternative is to begin conversion of the depleted UF6 inventory as soon as possible, either to uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible. This volume of the Final PEIS contains the comments and DOE's responses to comments received during the comment period. Chapter 2 contains photocopies of written submissions received by DOE on the Draft PEIS; DOE's responses to those comments are listed in Chapter 3. Chapter 4 provides the oral comments received at the public hearings and DOE's responses. Chapter 5 provides indices to comments and responses arranged by commentor name and by comment number

  8. Assessment of recently developed density functional approaches for the evaluation of the bond length alternation in polyacetylene

    Science.gov (United States)

    Jacquemin, Denis; Perpète, Eric. A.; Ciofini, Ilaria; Adamo, Carlo

    2005-04-01

    The bond length alternation (BLA) of increasingly long polyacetylene oligomers has been computed using various wavefunction methods of increasing accuracy and several DFT models, including standard GGA and the most-recent meta-GGA and hybrid functionals. Our results show the meta-GGA functionals do not offer any significant improvement with respect to the GGA approaches, both providing too small values for the BLA. More accurate results are obtained with hybrid approaches, where, instead, the percent of HF exchange rules the quantitative result. In particular, hybrids including 25% of HF exchange are the most accurate, whereas TPSSh, O3LYP, τ-HCTHh provide only poor estimates.

  9. Communicative Competence Inventory for Students Who Use Augmentative and Alternative Communication: A Team Approach

    Science.gov (United States)

    Chung, Yun-Ching; Douglas, Karen H.

    2014-01-01

    Students who use augmentative and alternative communication (AAC) represent a heterogonous group with complex communication needs. AAC--including aided communication means (e.g., pictures, devices) and unaided (e.g., signs, gestures)--is often used to support students who have difficulties with speech production, language comprehension, and…

  10. A study of the diffusion of alternative fuel vehicles : An agent-based modeling approach

    NARCIS (Netherlands)

    Zhang, Ting; Gensler, Sonja; Garcia, Rosanna

    2011-01-01

    This paper demonstrates the use of an agent-based model (ABM) to investigate factors that can speed the diffusion of eco-innovations, namely alternative fuel vehicles (AFVs). The ABM provides the opportunity to consider the interdependencies inherent between key participants in the automotive indust

  11. Ipsative measurement and the analysis of organizational values: an alternative approach for data analysis

    NARCIS (Netherlands)

    F.M. van Eijnatten; L.A. van der Ark; S.S. Holloway

    2015-01-01

    In this paper, the analysis and test of ipsative data will be discussed, and some alternative methods will be suggested. Following a review of the literature about ipsative measurement, the Competing Values Framework will be presented as a major application in the field of organizational culture and

  12. Alternative/Complementary Approaches to Treatment of Children with Autism Spectrum Disorders.

    Science.gov (United States)

    Levy, Susan E.; Hyman, Susan L.

    2002-01-01

    This article reviews common complementary or alternative medicine (CAM) treatments used to address symptoms of autistic spectrum disorders, including vitamin supplements, medications, antibiotics, antifungals, diet strategies, chelation/mercury detoxification, and nonbiologic treatments. Strategies that professionals may use in assessing the…

  13. INDOOR RADON REDUCTION IN CRAWL-SPACE HOUSES: A REVIEW OF ALTERNATIVE APPROACHES

    Science.gov (United States)

    An analysis has been completed of the performance, mechanisms, and costs of alternative technologies for preventing radon entry into the living areas of houses having crawl-space foundations. Sub-membrane depressurization (SMD) is consistently the most effective technique, often ...

  14. Fractional volume integration in two-dimensional NMR spectra: CAKE, a Monte Carlo approach.

    Science.gov (United States)

    Romano, Rocco; Paris, Debora; Acernese, Fausto; Barone, Fabrizio; Motta, Andrea

    2008-06-01

    Quantitative information from multi-dimensional NMR experiments can be obtained by peak volume integration. The standard procedure (selection of a region around the chosen peak and addition of all values) is often biased by poor peak definition because of peak overlap. Here we describe a simple method, called CAKE, for volume integration of (partially) overlapping peaks. Assuming the axial symmetry of two-dimensional NMR peaks, as it occurs in NOESY and TOCSY when Lorentz-Gauss transformation of the signals is carried out, CAKE estimates the peak volume by multiplying a volume fraction by a factor R. It represents a proportionality ratio between the total and the fractional volume, which is identified as a slice in an exposed region of the overlapping peaks. The volume fraction is obtained via Monte Carlo Hit-or-Miss technique, which proved to be the most efficient because of the small region and the limited number of points within the selected area. Tests on simulated and experimental peaks, with different degrees of overlap and signal-to-noise ratios, show that CAKE results in improved volume estimates. A main advantage of CAKE is that the volume fraction can be flexibly chosen so as to minimize the effect of overlap, frequently observed in two-dimensional spectra. PMID:18396078

  15. Different approaches to synovial membrane volume determination by magnetic resonance imaging: manual versus automated segmentation

    DEFF Research Database (Denmark)

    Østergaard, Mikkel

    1997-01-01

    methodology for volume determinations (maximal error 6.3%). Preceded by the determination of reproducibility and the optimal threshold at the available MR unit, automated 'threshold' segmentation appears to be acceptable when changes rather than absolute values of synovial membrane volumes are most important......Automated fast (5-20 min) synovial membrane volume determination by MRI, based on pre-set post-gadolinium-DTPA enhancement thresholds, was evaluated as a substitute for a time-consuming (45-120 min), previously validated, manual segmentation method. Twenty-nine knees [rheumatoid arthritis (RA) 13......, osteoarthritis (OA) 16] and 17 RA wrists were examined. At enhancement thresholds between 30 and 60%, the automated volumes (Syn(x%)) were highly significantly correlated to manual volumes (SynMan) (knees: rho = 0.78-0.91, P

  16. Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the american heart association.

    Science.gov (United States)

    Brook, Robert D; Appel, Lawrence J; Rubenfire, Melvyn; Ogedegbe, Gbenga; Bisognano, John D; Elliott, William J; Fuchs, Flavio D; Hughes, Joel W; Lackland, Daniel T; Staffileno, Beth A; Townsend, Raymond R; Rajagopalan, Sanjay

    2013-06-01

    Many antihypertensive medications and lifestyle changes are proven to reduce blood pressure. Over the past few decades, numerous additional modalities have been evaluated in regard to their potential blood pressure-lowering abilities. However, these nondietary, nondrug treatments, collectively called alternative approaches, have generally undergone fewer and less rigorous trials. This American Heart Association scientific statement aims to summarize the blood pressure-lowering efficacy of several alternative approaches and to provide a class of recommendation for their implementation in clinical practice based on the available level of evidence from the published literature. Among behavioral therapies, Transcendental Meditation (Class IIB, Level of Evidence B), other meditation techniques (Class III, Level of Evidence C), yoga (Class III, Level of Evidence C), other relaxation therapies (Class III, Level of Evidence B), and biofeedback approaches (Class IIB, Level of Evidence B) generally had modest, mixed, or no consistent evidence demonstrating their efficacy. Between the noninvasive procedures and devices evaluated, device-guided breathing (Class IIA, Level of Evidence B) had greater support than acupuncture (Class III, Level of Evidence B). Exercise-based regimens, including aerobic (Class I, Level of Evidence A), dynamic resistance (Class IIA, Level of Evidence B), and isometric handgrip (Class IIB, Level of Evidence C) modalities, had relatively stronger supporting evidence. It is the consensus of the writing group that it is reasonable for all individuals with blood pressure levels >120/80 mm Hg to consider trials of alternative approaches as adjuvant methods to help lower blood pressure when clinically appropriate. A suggested management algorithm is provided, along with recommendations for prioritizing the use of the individual approaches in clinical practice based on their level of evidence for blood pressure lowering, risk-to-benefit ratio, potential

  17. Ballistic aggregation: an alternative approach to modeling of silica sol-gel structures

    Energy Technology Data Exchange (ETDEWEB)

    Grzegorczyk, Marcin; Rybaczuk, Marek; Maruszewski, Krzysztof

    2004-03-01

    An algorithm based on ballistic aggregation is discussed as an alternative to the commonly used, much slower diffusion-based algorithms for modeling of atomic structure of silica gels. The algorithm is shown to be capable of producing a wide range of structures: from extremely porous to compact (dense) ones. The importance of capture distance as a controlling parameter is discussed. Electron microscope images of actual silica gels morphologically very similar to the rendered images of the simulated aggregates are shown.

  18. TEACHING LISTENING THROUGH PHONOLOGY:AN ALTERNATIVE APPROACH FOR CHINESE TEACHERS OF ENGLISH

    Institute of Scientific and Technical Information of China (English)

    FrancisDoogan; MariaBjorningGyde

    2004-01-01

    With very limited exposure to spoken English, teachers in China are presented with a number of challenges in their own proficiency and subsequent teaching of listening and speaking, ranging from the type of approach they take to the teaching of these skills to the quality of voice which they model for their learners. A common approach to teaching listening in China

  19. Alternative approaches to derive disability weights in injuries: do they make a difference?

    NARCIS (Netherlands)

    J.A. Haagsma (Juanita); S. Polinder (Suzanne); G.J. Bonsel (Gouke); E.F. van Beeck (Ed); S. Mulder (Saakje)

    2009-01-01

    textabstractBACKGROUND: In burden of disease studies, several approaches are used to assess disability weights, a scaling factor necessary to compute years lived with disability (YLD). The aim of this study was to quantify disability weights for injury consequences with two competing approaches, (a)

  20. A Comparison of Two Different Approaches to Hydrazine Loading of Spacecraft: The Use of SCAPE and Alternative Approaches

    Science.gov (United States)

    Houseman, John; Patzold, Jack D.; Jackson, Julie R.; Brown, Pamela R.

    1999-01-01

    The loading of spacecraft with Hydrazine type fuels has long been recognized as a hazardous operation. This has led to safety strategies that include the use of SCAPE protective suits for personnel. The use of SCAPE suits have an excellent safety record, however there are associated drawbacks. Drawbacks include the high cost of maintaining and cleaning the suits, reduced mobility and dexterity when wearing the suits, the requirement for extensive specialized health and safety training, and the need to rotate personnel every two hours. A study was undertaken to look at procedures and/or equipment to eliminate or reduce the time spent in SCAPE-type operations. The major conclusions are drawn from observations of the loading of the JPL/NASA spacecraft Deep Space One (DS1) at KSC and the loading of a commercial communications satellite by Motorola at Vandenberg AF Base. The DS1 operations require extensive use of SCAPE suits, while the Motorola operation uses only SPLASH attire with a two-man team on standby in SCAPE. The Motorola team used very different loading equipment and procedures based on an integrated approach involving the propellant supplier. Overall, the Motorola approach was very clean, much faster and simpler than the DS1 procedure. The DS1 spacecraft used a bladder in the propellant tank, whereas the Motorola spacecraft used a Propellant Management Device (PMD). The Motorola approach cannot be used for tanks with bladders. To overcome this problem, some new procedures and new equipment are proposed to enable tanks with bladders to be loaded without using SCAPE, using a modified Motorola approach. Overall, it appears feasible to adopt the non-SCAPE approach while maintaining a very high degree of safety and reliability.

  1. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation.

    Science.gov (United States)

    McNamee, Pauline; Hibatallah, Jalila; Costabel-Farkas, Margit; Goebel, Carsten; Araki, Daisuke; Dufour, Eric; Hewitt, Nicola J; Jones, Penny; Kirst, Annette; Le Varlet, Béatrice; Macfarlane, Martin; Marrec-Fairley, Monique; Rowland, Joanna; Schellauf, Florian; Scheel, Julia

    2009-07-01

    The need for alternative approaches to replace the in vivo rabbit Draize eye test for evaluation of eye irritation of cosmetic ingredients has been recognised by the cosmetics industry for many years. Extensive research has lead to the development of several assays, some of which have undergone formal validation. Even though, to date, no single in vitro assay has been validated as a full replacement for the rabbit Draize eye test, organotypic assays are accepted for specific and limited regulatory purposes. Although not formally validated, several other in vitro models have been used for over a decade by the cosmetics industry as valuable tools in a weight of evidence approach for the safety assessment of ingredients and finished products. In light of the deadlines established in the EU Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision-tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. Furthermore, recommendations are given on how remaining data gaps and research needs can be addressed. PMID:19393279

  2. New volume and inverse volume operators for loop quantum gravity

    OpenAIRE

    Yang, Jinsong; Ma, Yongge

    2016-01-01

    A new alternative volume operator is constructed for loop quantum gravity by using the so-called co-triad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The ne...

  3. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation.

    Science.gov (United States)

    Macfarlane, Martin; Jones, Penny; Goebel, Carsten; Dufour, Eric; Rowland, Joanna; Araki, Daisuke; Costabel-Farkas, Margit; Hewitt, Nicola J; Hibatallah, Jalila; Kirst, Annette; McNamee, Pauline; Schellauf, Florian; Scheel, Julia

    2009-07-01

    Evaluation of the skin irritancy and corrosivity potential of an ingredient is a necessity in the safety assessment of cosmetic ingredients. To date, there are two formally validated alternatives to the rabbit Draize test for skin corrosivity in place, namely the rat skin transcutaneous electrical resistance (TER) assay and the Human Skin Model Test using EpiSkin, EpiDerm and SkinEthic reconstructed human epidermal equivalents. For skin irritation, EpiSkin, EpiDerm and SkinEthic are validated as stand-alone test replacements for the rabbit Draize test. Data from these tests are rarely considered in isolation and are evaluated in combination with other factors to establish the overall irritating or corrosive potential of an ingredient. In light of the deadlines established in the Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. In conclusion, the safety assessments for skin irritation/corrosion of new chemicals for use in cosmetics can be confidently accomplished using exclusively alternative methods. PMID:19393278

  4. Extracorporeal staple technique: an alternative approach to the treatment of critical colostomy stenosis

    OpenAIRE

    Skokowski, Jarosław; Bobowicz, Maciej; Kalinowska, Aleksandra

    2015-01-01

    We describe an extracorporeal staple technique used to treat severe colostomy stenosis under analgo-sedation, thus avoiding relaparotomy. The surgery is performed under short-term sedation. The orifice of the stoma is widened and overgrowing skin is excised. The volume and diameter of the stoma are assessed. The anvil of a circular stapler device is inserted into the lumen of the colostomy. First bowel layers and then skin are closed with purse-string sutures. One firing of the stapler is use...

  5. The influence of trading volume on market efficiency: The DCCA approach

    Science.gov (United States)

    Sukpitak, Jessada; Hengpunya, Varagorn

    2016-09-01

    For a single market, the cross-correlation between market efficiency and trading volume, which is an indicator of market liquidity, is attentively analysed. The study begins with creating time series of market efficiency by applying time-varying Hurst exponent with one year sliding window to daily closing prices. The time series of trading volume corresponding to the same time period used for the market efficiency is derived from one year moving average of daily trading volume. Subsequently, the detrended cross-correlation coefficient is employed to quantify the degree of cross-correlation between the two time series. It was found that values of cross-correlation coefficient of all considered stock markets are close to 0 and are clearly out of range in which correlation being considered significant in almost every time scale. Obtained results show that the market liquidity in term of trading volume hardly has effect on the market efficiency.

  6. Different approaches to synovial membrane volume determination by magnetic resonance imaging: manual versus automated segmentation

    DEFF Research Database (Denmark)

    Østergaard, Mikkel

    1997-01-01

    methodology for volume determinations (maximal error 6.3%). Preceded by the determination of reproducibility and the optimal threshold at the available MR unit, automated 'threshold' segmentation appears to be acceptable when changes rather than absolute values of synovial membrane volumes are most important......, osteoarthritis (OA) 16] and 17 RA wrists were examined. At enhancement thresholds between 30 and 60%, the automated volumes (Syn(x%)) were highly significantly correlated to manual volumes (SynMan) (knees: rho = 0.78-0.91, P < 10(-5) to < 10(-9); wrists: rho = 0.87-0.95, P < 10(-4) to < 10(-6)). The absolute...... values of the automated estimates were extremely dependent on the threshold chosen. At the optimal threshold of 45%, the median numerical difference from SynMan was 7 ml (17%) in knees and 2 ml (25%) in wrists. At this threshold, the difference was not related to diagnosis, clinical inflammation or...

  7. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

    International Nuclear Information System (INIS)

    The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials

  8. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials.

  9. The development, implementation and evaluation of alternative approaches to teaching and learning in the chemistry laboratory

    OpenAIRE

    Kelly, Orla

    2005-01-01

    The focus of the thesis is on the evaluation of the effect of the implementation of a three-hour per week problem-based learning (PBL) module for 1SI year undergraduate students. The research questions are outlined below: • What approaches to learning are undergraduate students adopting at the initial stage of tertiary education? • Are student approaches to learning related to age/gender/ time in university/achievement in examinations? • Can a PBL module in chemistry be developed ...

  10. Alternative approaches for the treatment of airway diseases: focus on nanoparticle medicine.

    Science.gov (United States)

    Ratemi, E; Sultana Shaik, A; Al Faraj, A; Halwani, R

    2016-08-01

    Despite the various treatment options and international guidelines currently available for the appropriate therapeutic management of asthma, a large population of patients with asthma continues to have poorly controlled disease. There is therefore a need for novel approaches to achieve better asthma control, especially for severe asthmatics. This review discusses the use of nanoparticles for the specific targeting of inflammatory pathways as a promising approach for the effective control of severe persistent asthma as well as other chronic inflammatory diseases. PMID:27404025

  11. Interactive volume exploration of petascale microscopy data streams using a visualization-driven virtual memory approach

    KAUST Repository

    Hadwiger, Markus

    2012-12-01

    This paper presents the first volume visualization system that scales to petascale volumes imaged as a continuous stream of high-resolution electron microscopy images. Our architecture scales to dense, anisotropic petascale volumes because it: (1) decouples construction of the 3D multi-resolution representation required for visualization from data acquisition, and (2) decouples sample access time during ray-casting from the size of the multi-resolution hierarchy. Our system is designed around a scalable multi-resolution virtual memory architecture that handles missing data naturally, does not pre-compute any 3D multi-resolution representation such as an octree, and can accept a constant stream of 2D image tiles from the microscopes. A novelty of our system design is that it is visualization-driven: we restrict most computations to the visible volume data. Leveraging the virtual memory architecture, missing data are detected during volume ray-casting as cache misses, which are propagated backwards for on-demand out-of-core processing. 3D blocks of volume data are only constructed from 2D microscope image tiles when they have actually been accessed during ray-casting. We extensively evaluate our system design choices with respect to scalability and performance, compare to previous best-of-breed systems, and illustrate the effectiveness of our system for real microscopy data from neuroscience. © 1995-2012 IEEE.

  12. Contributions of new approaches to the formation of alternative public health

    Directory of Open Access Journals (Sweden)

    Marleny Valencia A

    2011-05-01

    Full Text Available AbstractThis article discusses the possibility of a different way from traditional to raise health problems in public health context, answering its guiding question: How the contemporary approaches to public heath help to understand it and size its projection in the coming years? Initially, we will make a brief characterization of conventional public health, in order to show its limitations to answer people’s health problems. Then we enter to the contemporary approaches or tendencies, specifically those developed in the critical school framework, because it’s on them where the approaches that significantly contribute to the health public conformation converge. Among the selected currents we have: the critical theory, the social medicine, the collective health, social determinants of health, the gender approach and the complexity theory, approaches that contribute to a different way of public health working and to have always in mind the importance of the subject in the boarding of health problems. Likewise, the technologic reason directed knowledge must be changed in order to reach the multiculturalism, this accepting other knows as valid to the construction of know.

  13. Two-photon dilepton production in proton-proton collisions: two alternative approaches

    CERN Document Server

    Luszczak, Marta; Szczurek, Antoni

    2015-01-01

    We investigate different methods to incorporate the effect of photons in hard processes. We compare two different approaches used for calculating cross sections for two-photon $p p \\to l^+ l^- X$ process. In one of the approaches photon is treated as a collinear parton in the proton. In the second approach recently proposed a $k_T$-factorization method is used. We discuss how results of the collinear parton model depend on the initial condition for the QCD evolution and discuss an approximate treatment where photon is excluded from the combined QCD-QED evolution. We demonstrate that it is not necessary to put photon into the evolution equation as often done recently but it is sufficient to use a simplified approach in which photon couples to quarks and antiquarks which by themselves undergo DGLAP evolution equations. We discuss sensitivity of the results to the choice of structure function parametrization and experimental cuts in the $k_T$-factorization approach. A new optimal structure function parametrizati...

  14. Motivation and Dispositions: Alternative Approaches to Explain the Performance of Critical Thinking Skills

    Directory of Open Access Journals (Sweden)

    Jorge Valenzuela

    2014-10-01

    Full Text Available Critical thinking depends on the mastery degrees of some skills and on the will to activate them when reasoning. Traditionally, this second aspect has been focused from a disposition approach (Facione, 1990. However, this perspective demonstrates problems in theoretical as in practical level to explain and to develop critical thinking. For this, it is proposed to approach the problem from the Motivation perspective (Eccles and Wigfield, 2002. In this context, our research deals with the evaluation of the convenience to choose one perspective or another to explain the performance of critical thinking, both theoretically and in its predictive capacity. Thus, along with theoretically analyze the strengths and weaknesses of both approaches and it was compared measures of dispositions (CCTDI, motivation (EMPC and critical thinking (CCTST in a sample of Spanish university students. The results show that the variability in critical thinking performance is better explained by the motivation than by dispositional approach. Finally, the theoretical and practical convenience of motivational approach in this matter is discussed.

  15. Transformation of theoretical-methodological approaches and methodical tools of the individual and territory welfare diagnostics. Part 1. From spreading to the alternative diagnostics approaches (background

    Directory of Open Access Journals (Sweden)

    Aleksandr Anatolyevich Kuklin

    2014-09-01

    Full Text Available This article presents an evolution of theoretical and methodological approaches to the welfare study. Existing theories of wellbeing are grouped according to accounted method of goods and resources distribution among society members. As a welfare future as a category we highlight objective (measured and subjective (estimated components. Based on the analysis of scientific literature we determine the ratio of individual and social welfare. The main differences between the categories of “ welfare” and “wealth” are given. The main difference consists in multidirectional changes of welfare and wealth for an increase (decrease in income of the individual (country. In this article we present an analysis of modern approaches to the definition of welfare: state, institutional and expendable approach. The welfare level estimation is complicated due to the need to consider the subjective component. The article provides an analysis of existing approaches to quantitative welfare evaluation ranging from the most common techniques (HDI, GDP to alternative techniques (Happy Planet Index.Methodological devices are structured by levels of welfare assessment objects (world, country, region, people. Based on the analysis of the advantages and disadvantages of methods we can conclude that the most reliable method is a comprehensive approach, which includes economic, environmental, social, vital and infrastructure indicators. The author’s approach to the formation of a complex methodological tool for individual and territory welfare estimation is presented in this article.

  16. Lifeline electric rates and alternative approaches to the problems of low-income ratepayers. Ten case studies of implemented programs

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Program summaries, issue developments, governmental processes, and impacts are discussed for 10 case studies dealing with lifeline electric rates and alternative approaches to the problems of low-income ratepayers, namely; the Boston Edison rate freeze; the California lifeline; Florida Power and Light conservation rate; the Iowa-Illinois Gas and Electric small-use rate; the Maine demonstration lifeline program; the Massachusetts Electric Company A-65 rate; the Michigan optional senior citizen rate; the Narragansett Electric Company A-65 SSI rate; the Northern States Power Company conservation rate break; and the Potomac Electric Power Company rate freeze. (MCW)

  17. Alternative Approaches to Treating Children and Families Who Exhibit Behavior Problems: Introduction.

    Science.gov (United States)

    Pooley, Richard C.

    The author describes the phenomena of increased disturbing behaviors shown by children (6 to 12 years old) and the cost of such behaviors in terms of dollars and human misery. It is suggested that certain diseconomies exist in the traditional approach to dealing with the phenomena and that perhaps innovation is indicated. (SBH)

  18. A Suggested Approach for a Cost Analysis of Alternative IMS Configurations.

    Science.gov (United States)

    Besel, Ronald

    An approach to a cost analysis of pilot, prototype, model and operational versions of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS) is described. Five classes of systems (conceptual, pilot, prototype, model and operational) are defined, and a system development process relating classes of systems in presented.…

  19. Words as Species: An Alternative Approach to Estimating Productive Vocabulary Size

    Science.gov (United States)

    Meara, Paul M.; Alcoy, Juan Carlos Olmos

    2010-01-01

    This paper addresses the issue of how we might be able to assess productive vocabulary size in second language learners. It discusses some previous attempts to develop measures of this sort, and argues that a fresh approach is needed in order to overcome some persistent problems that dog research in this area. The paper argues that there might be…

  20. The Dutch IOR approach to organizational design : An alternative to business process re-engineering?

    NARCIS (Netherlands)

    van Eijnatten, FM; van der Zwaan, AH

    1998-01-01

    This paper presents the current Dutch sociotechnical design approach to integral organizational renewal in a contextual way. Both its design theory and intervention processes are reviewed and some aggregated empirical evidence is presented. Next, the paper compares the ideas developed in the Dutch a

  1. Critical Pedagogy in an EFL Teaching Context: An Ignis Fatuus or an Alternative Approach?

    Science.gov (United States)

    Sadeghi, Sima

    2008-01-01

    Language teaching has, for much of its history, been subject to the heavy "evangelical zeal" of the centers who have exported their theories, methods derived from these, approaches, materials, and books to the developing countries "often with doubtful relevance to the sociological, educational and economic context of the Outer Circle." Second…

  2. A Partnership Model for Evaluation: Considering an Alternate Approach to the Internal-External Evaluation Debate

    Science.gov (United States)

    Le Menestrel, Suzanne M.; Walahoski, Jill S.; Mielke, Monica B.

    2014-01-01

    The 4-H youth development organization is a complex public--private partnership between the U.S. Department of Agriculture's National Institute of Food and Agriculture, the nation's Cooperative Extension system and National 4-H Council, a private, nonprofit partner. The current article is focused on a partnership approach to the…

  3. An Alternative Approach for MBA Mentor Programs: Empower the Protégé

    Science.gov (United States)

    Artis, Andrew B.

    2013-01-01

    A new approach is proposed to maximize the benefits of mentor relationships between master of business administration (MBA) students and executives by empowering students to select and recruit their own mentors, and then be responsible for managing those relationships. This mentor program is designed to be short but intensive. First-year MBA…

  4. Reflections on human Pavlovian decelerative heart-rate conditioning with negative tilt as US: alternative approaches.

    Science.gov (United States)

    Furedy, J J

    1992-01-01

    The negative-tilt preparation that has been reported since the late seventies is a specific form of Pavlovian conditioning that is of scientific interest and has potential applications. In this paper I reflect on the usefulness, to the development of this preparation, of two approaches to Pavlovian conditioning. One approach is the older S-R learning, stimulus-substitution paradigm exemplified by learning texts of the sixties. The other is the modern, Tolman-like view, according to which the phenomenon of Pavlovian conditioning is "now described as the learning of relations among events so as to allow the organism to represent its environment." The three assumptions encapsulated by this approach are: (a) that only CS-US contingency relations are learned; (b) that teleological modes of explanations are adequate; (c) that the representational theory of knowledge is sound. Concerning Pavlovian conditioning in general, questions been raised in the literature for all three assumptions; they have not been adequately answered. Regarding the specific problem of developing the human Pavlovian heart-rate decelerative conditioning with negative tilt as the US, I suggest that the cognitive approach has been much less helpful than the older, S-R, stimulus-substitution paradigm. Nevertheless, other literature clearly indicates that the cognitive, S-S approach has generated considerable interest and research, especially in preparations like the conditioned emotional response (CER), which are CS-IR ones in the sense that the effects on the CR are assessed indirectly through measuring an indicator or instrumental response (IR).(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Alternative approach for fire suppression of class A, B and C fires in gloveboxes

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberger, Mark S [Los Alamos National Laboratory; Tsiagkouris, James A [Los Alamos National Laboratory

    2011-02-10

    Department of Energy (DOE) Orders and National Fire Protection Association (NFPA) Codes and Standards require fire suppression in gloveboxes. Several potential solutions have been and are currently being considered at Los Alamos National Laboratory (LANL). The objective is to provide reliable, minimally invasive, and seismically robust fire suppression capable of extinguishing Class A, B, and C fires; achieve compliance with DOE and NFPA requirements; and provide value-added improvements to fire safety in gloveboxes. This report provides a brief summary of current approaches and also documents the successful fire tests conducted to prove that one approach, specifically Fire Foe{trademark} tubes, is capable of achieving the requirement to provide reliable fire protection in gloveboxes in a cost-effective manner.

  6. A pilot study evaluating alternative approaches of academic detailing in rural family practice clinics

    Directory of Open Access Journals (Sweden)

    Hartung Daniel M

    2012-12-01

    Full Text Available Abstract Background Academic detailing is an interactive, convenient, and user-friendly approach to delivering non-commercial education to healthcare clinicians. While evidence suggests academic detailing is associated with improvements in prescribing behavior, uncertainty exists about generalizability and scalability in diverse settings. Our study evaluates different models of delivering academic detailing in a rural family medicine setting. Methods We conducted a pilot project to assess the feasibility, effectiveness, and satisfaction with academic detailing delivered face-to-face as compared to a modified approach using distance-learning technology. The recipients were four family medicine clinics within the Oregon Rural Practice-based Research Network (ORPRN. Two clinics were allocated to receive face-to-face detailing and two received outreach through video conferencing or asynchronous web-based outreach. Surveys at midpoint and completion were used to assess effectiveness and satisfaction. Results Each clinic received four outreach visits over an eight month period. Topics included treatment-resistant depression, management of atypical antipsychotics, drugs for insomnia, and benzodiazepine tapering. Overall, 90% of participating clinicians were satisfied with the program. Respondents who received in person detailing reported a higher likelihood of changing their behavior compared to respondents in the distance detailing group for five of seven content areas. While 90%-100% of respondents indicated they would continue to participate if the program were continued, the likelihood of participation declined if only distance approaches were offered. Conclusions We found strong support and satisfaction for the program among participating clinicians. Participants favored in-person approaches to distance interactions. Future efforts will be directed at quantitative methods for evaluating the economic and clinical effectiveness of detailing in rural

  7. Alternative Approach Strategies For Buyer-Seller Relations With The Peoples Republic Of China

    OpenAIRE

    Johnston, W. J.

    1988-01-01

    This paper examines the issues involved in buyer-seller relations for industrial product sales in the People's Republic of China. The need is genuine in many product categories including plant technology, high technology, and infrastructure. The problem is that buying policies and procedures for foreign firms are still emerging, and therefore, unclear and confusing. Three approach strategies for buyer-seller relations with China are presented: the authorized "buying group," the "agency" repre...

  8. An Alternative Approach to Combine Orbital Prosthesis and Obturator: A Case Report

    OpenAIRE

    Soganci, Gokce; Yalug, Suat; Kocacikli, Mustafa

    2011-01-01

    This report describes a different approach for diminishing the movements of orbital prosthesis during mimic movements and chewing function. Mechanical devices such as magnets are used to enhance the retention in case lack of the implants. However rigid fixation of obturator and orbital prosthesis can result in movements of the orbital prosthesis during mastication. In this case obturator and orbital prosthesis are combined by magnets. However this combination is not rigid because of an active...

  9. Random spectrum loading of dental implants: An alternative approach to functional performance assessment.

    Science.gov (United States)

    Shemtov-Yona, K; Rittel, D

    2016-09-01

    The fatigue performance of dental implants is usually assessed on the basis of cyclic S/N curves. This neither provides information on the anticipated service performance of the implant, nor does it allow for detailed comparisons between implants unless a thorough statistical analysis is performed, of the kind not currently required by certification standards. The notion of endurance limit is deemed to be of limited applicability, given unavoidable stress concentrations and random load excursions, that all characterize dental implants and their service conditions. We propose a completely different approach, based on random spectrum loading, as long used in aeronautical design. The implant is randomly loaded by a sequence of loads encompassing all load levels it would endure during its service life. This approach provides a quantitative and comparable estimate of its performance in terms of lifetime, based on the very fact that the implant will fracture sooner or later, instead of defining a fatigue endurance limit of limited practical application. Five commercial monolithic Ti-6Al-4V implants were tested under cyclic, and another 5 under spectrum loading conditions, at room temperature and dry air. The failure modes and fracture planes were identical for all implants. The approach is discussed, including its potential applications, for systematic, straightforward and reliable comparisons of various implant designs and environments, without the need for cumbersome statistical analyses. It is believed that spectrum loading can be considered for the generation of new standardization procedures and design applications. PMID:27161957

  10. The British Climate Change Act: a critical evaluation and proposed alternative approach

    Science.gov (United States)

    Pielke, Roger A., Jr.

    2009-04-01

    This paper evaluates the United Kingdom's Climate Change Act of 2008 in terms of the implied rates of decarbonization of the UK economy for a short-term and a long-term target established in law. The paper uses the Kaya identity to structure the evaluation, employing both a bottom up approach (based on projections of future UK population, economic growth, and technology) and a top down approach (deriving implied rates of decarbonization consistent with the targets and various rates of projected economic growth). Both approaches indicate that the UK economy would have to achieve annual rates of decarbonization in excess of 4 or 5%. To place these numbers in context, the UK would have to achieve the 2006 carbon efficiency of France by about 2015, a level of effort comparable to the building of about 30 new nuclear power plants, displacing an equivalent amount of fossil energy. The paper argues that the magnitude of the task implied by the UK Climate Change Act strongly suggests that it is on course to fail, and discusses implications.

  11. An alternative approach to characterize the topology of complex networks and its application in epidemic spreading

    Institute of Scientific and Technical Information of China (English)

    Zonghua LIU; Xiaoyan WU; Pak-Ming HUI

    2009-01-01

    Based on the mean-field approach, epidemic spreading has been well studied. However, the mean-field approach cannot show the detailed contagion process, which is important in the control of epidemic. To fill this gap, we present a novel approach to study how the topological struc-ture of complex network influences the concrete process of epidemic spreading. After transforming the network struc-ture into hierarchical layers, we introduce a set of new pa-rameters, i.e., the average fractions of degree for outgoing, ingoing, and remaining in the same layer, to describe the infection process. We find that this set of parameters are closely related to the degree distribution and the clustering coefficient but are more convenient than them in describ-ing the process of epidemic spreading. Moreover, we find that the networks with exponential distribution have slower spreading speed than the networks with power-law degree distribution. Numerical simulations have confirmed the the-oretical predictions.

  12. Alternatives to relational databases in precision medicine: Comparison of NoSQL approaches for big data storage using supercomputers

    Science.gov (United States)

    Velazquez, Enrique Israel

    Improvements in medical and genomic technologies have dramatically increased the production of electronic data over the last decade. As a result, data management is rapidly becoming a major determinant, and urgent challenge, for the development of Precision Medicine. Although successful data management is achievable using Relational Database Management Systems (RDBMS), exponential data growth is a significant contributor to failure scenarios. Growing amounts of data can also be observed in other sectors, such as economics and business, which, together with the previous facts, suggests that alternate database approaches (NoSQL) may soon be required for efficient storage and management of big databases. However, this hypothesis has been difficult to test in the Precision Medicine field since alternate database architectures are complex to assess and means to integrate heterogeneous electronic health records (EHR) with dynamic genomic data are not easily available. In this dissertation, we present a novel set of experiments for identifying NoSQL database approaches that enable effective data storage and management in Precision Medicine using patients' clinical and genomic information from the cancer genome atlas (TCGA). The first experiment draws on performance and scalability from biologically meaningful queries with differing complexity and database sizes. The second experiment measures performance and scalability in database updates without schema changes. The third experiment assesses performance and scalability in database updates with schema modifications due dynamic data. We have identified two NoSQL approach, based on Cassandra and Redis, which seems to be the ideal database management systems for our precision medicine queries in terms of performance and scalability. We present NoSQL approaches and show how they can be used to manage clinical and genomic big data. Our research is relevant to the public health since we are focusing on one of the main

  13. New Approach to Purging Monitoring Wells: Lower Flow Rates Reduce Required Purging Volumes and Sample Turbidity

    Science.gov (United States)

    It is generally accepted that monitoring wells must be purged to access formation water to obtain “representative” ground water quality samples. Historically anywhere from 3 to 5 well casing volumes have been removed prior to sample collection to evacuate the standing well water...

  14. Development of a healthy biscuit: an alternative approach to biscuit manufacture

    Directory of Open Access Journals (Sweden)

    Davies B

    2006-03-01

    Full Text Available Abstract Objective Obesity (BMI >30 and related health problems, including coronary heart disease (CHD, is without question a public health concern. The purpose of this study was to modify a traditional biscuit by the addition of vitamin B6, vitamin B12, Folic Acid, Vitamin C and Prebiotic fibre, while reducing salt and sugar. Design Development and commercial manufacture of the functional biscuit was carried out in collaboration with a well known and respected biscuit manufacturer of International reputation. The raw materials traditionally referred to as essential in biscuit manufacture, i.e. sugar and fat, were targeted for removal or reduction. In addition, salt was completely removed from the recipe. Participants University students of both sexes (n = 25 agreed to act as subjects for the study. Ethical approval for the study was granted by the University ethics committee. The test was conducted as a single blind crossover design, and the modified and traditional biscuits were presented to the subjects under the same experimental conditions in a random fashion. Results No difference was observed between the original and the modified product for taste and consistency (P > 0.05. The modified biscuit was acceptable to the consumer in terms of eating quality, flavour and colour. Commercial acceptability was therefore established. Conclusion This study has confirmed that traditional high-fat and high-sugar biscuits which are not associated with healthy diets by most consumers can be modified to produce a healthy alternative that can be manufactured under strict commercial conditions.

  15. Advance commitment: an alternative approach to the family veto problem in organ procurement.

    Science.gov (United States)

    De Wispelaere, Jurgen; Stirton, Lindsay

    2010-03-01

    This article tackles the current deficit in the supply of cadaveric organs by addressing the family veto in organ donation. The authors believe that the family veto matters-ethically as well as practically-and that policies that completely disregard the views of the family in this decision are likely to be counterproductive. Instead, this paper proposes to engage directly with the most important reasons why families often object to the removal of the organs of a loved one who has signed up to the donor registry-notably a failure to understand fully and deliberate on the information and a reluctance to deal with this sort of decision at an emotionally distressing time. To accommodate these concerns it is proposed to separate radically the process of information, deliberation and agreement about the harvesting of a potential donor's organs from the event of death and bereavement through a scheme of advance commitment. This paper briefly sets out the proposal and discusses in some detail its design as well as what is believed to be the main advantages compared with the leading alternatives. PMID:20212000

  16. An alternative approach to compensators design for photon beams used in radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Jurkovic, S. [University Hospital, Department of Radiotherapy, Physics Division, Kresimirova 42, 51000 Rijeka (Croatia); Zauhar, G. [School of Medicine, Department of Physics, Brace Branchetta 20, 51000 Rijeka (Croatia)], E-mail: gordz@medri.hr; Bistrovic, M. [Hospital for Tumors, Radiotherapy Department, Ilica 272, 10000 Zagreb (Croatia); Faj, D. [University Hospital, Department of Radiotherapy and Oncology, J. Huttlera 4, 31000 Osijek (Croatia); Kaliman, Z. [Faculty of Sciences and Arts, Department of Physics, Omladinska 14, 51000 Rijeka (Croatia); Smilovic Radojcic, D. [University Hospital, Department of Radiotherapy, Physics Division, Kresimirova 42, 51000 Rijeka (Croatia)

    2007-09-21

    The use of compensators in order to achieve desired dose distribution has a long history and is a well-established technique in radiation therapy planning. There are several different calculation methods for determining a compensator's thickness. An alternative method that is based on the Cunningham's modification of Clarkson's method to calculate scattered radiation in beams with an inhomogeneous cross-section is proposed. It is well known that the total dose distribution of radiotherapy photon beam consists of the contributions of the primary beam, attenuated by the tissue layer, and the scattered radiation generated by the primary radiation in single and multiple photon scatter events. The scattered component can be represented as a function of the primary radiation. The central point of our method is the numerical estimation of the primary distribution required to achieve the desired total distribution. Now using the calculated primary distribution, the shape of the modulator could be determined. In this way the contribution of the scattered component is validated in a more accurate way than using effective attenuation coefficients, which is a common practice. The method is verified in various clinical situations and compared with the standard method. The accuracy, although dependent on geometry, was improved by at least 2%. With more complex geometries there is an even higher gain in accuracy with our method when compared to the standard method.

  17. Cloud Computing as an Alternative IT Solution for SMEs: A System Dynamic Approach

    Directory of Open Access Journals (Sweden)

    Mochamad Arief Abdillah

    2014-12-01

    Full Text Available Small medium enterprises (SMEs play a big role for GDP in Indonesia. In 2012, SMEs made contribution 59,08 % for GDP Indonesia. The amount of SMEs in Indonesia is 99,99 % from total company in Indonesia. From that data, we know that SMEs is very big market in Indonesia. However, despite many big contributions that SMEs gave, SMEs also have challenges for themselves. The limitation of capital is one of challenges that SMEs have to face. The limit of capital make SMEs spend their capital wisely. They have to think very carefully how to expand their business. Is it profitable or not. In this paper we want to understand about the phenomenon why SMEs are hard to implement information and system technology. We used observation and secondary data to construct the variables. After that, we use the variables to build the model using system dynamics. And then we simulate it to know the impact implementation of information technology to flow business of SMEs. To propose new alternative technology (cloud computing, we modified the variables in the model and simulated it. We compared the result between own information technology and cloud computing. The result shows that cloud computing is suitable to be implemented in SMEs.Keywords : Cloud computing, SME, System Dynamic, Information Technology, Model

  18. Towards an alternative approach to personhood in the end of life questions.

    Science.gov (United States)

    Hellsten, S K

    2000-11-01

    Within the Western bioethical framework, we make a distinction between two dominant interpretations of the meaning of moral personhood: the naturalist and the humanist one. While both interpretations of moral personhood claim to promote individual autonomy and rights, they end up with very different normative views on the practical and legal measures needed to realize these values in every day life. Particularly when we talk about the end of life issues it appears that in general the arguments for euthanasia are drawn from the naturalist interpretation of moral personhood while the arguments against euthanasia, for their part, are derived from the idealist and/or humanist understanding of the same concept. This article focuses on examining the metaphysical assumptions and internal contradiction found behind the opposing arguments presented by two prominent philosophers of these two traditions: Peter Singer and Ludger Honnefelder. The author claims that neither side of the debate succeeds in defending its normative position without reconsidering how to take the social aspects of moral personhood into account. The author holds that, despite our need to set individual's decision making into social context, the current communitarian narrative concept of personhood fails to offer a convincing alternative. Instead of merely trying to replace psychological and atomistic view of personhood with a collective understanding of an individual's moral identity, we need to discuss the normative relation between the concept of 'moral personhood' and the demand for respect of individual autonomy in Western bioethics within a wider philosophical perspective. PMID:11196219

  19. Selection Methodology Approach to Preferable and Alternative Sites for the First NPP Project in Yemen

    Energy Technology Data Exchange (ETDEWEB)

    Kassim, Moath [Kyunghe Univ., Yongin (Korea, Republic of); Kessel, David S. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2015-05-15

    The purpose of this paper is to briefly present the methodology and results of the first siting study for the first nuclear power plant (NPP) in Yemen. In this study it has been demonstrated that there are suitable sites for specific unit/units power of 1000 MWt (about 300 MWe) nuclear power plant. To perform the site selection, a systematic selection method was developed. The method uses site-specific data gathered by literature review and expert judgement to identify the most important site selection criteria. A two-step site selection process was used. Candidate sites were chosen that meet a subset of the selection criteria that form the most important system constraints. These candidate sites were then evaluated against the full set of selection criteria using the Analytical Hierarchy Process Method (AHP). Candidate sites underwent a set of more specific siting criteria weighted by expert judgment to select preferable sites and alternatives using AHP method again. Expert Judgment method was used to rank and weight the importance of each criteria, then AHP method used to evaluate and weight the relation between criterion to criterion and between all criteria against the global weight. Then logical decision software was used to rank sites upon their weighting value.

  20. Panels Manufactured from Vegetable Fibers: An Alternative Approach for Controlling Noises in Indoor Environments

    Directory of Open Access Journals (Sweden)

    Leopoldo Pacheco Bastos

    2012-01-01

    Full Text Available Noise control devices such as panels and barriers, when of high efficiency, generally are of difficult acquisition due to high costs turning in many cases their use impracticable, mainly for limited budget small-sized companies. There is a huge requirement for new acoustic materials that have satisfactory performance, not only under acoustic aspect but also other relevant ones and are of low cost. Vegetable fibers are an alternative solution when used as panels since they promise satisfactory acoustic absorption, according to previous researches, exist in abundance, and derive from renewable sources. This paper, therefore, reports on the development of panels made from vegetable fibers (coconut, palm, sisal, and açaí, assesses their applicability by various experimental (flammability, odor, fungal growth, and ageing tests, and characterize them acoustically in terms of their sound absorption coefficients on a scale model reverberant chamber. Acoustic results point out that the aforementioned fiber panels play pretty well the role of a noise control device since they have compatible, and in some cases, higher performance when compared to commercially available conventional materials.

  1. Butterfly cartilage tympanoplasty: An alternative approach for management of small- and medium-sized perforations

    Directory of Open Access Journals (Sweden)

    Ashish Kumar Maurya

    2016-01-01

    Full Text Available Objective: To evaluate the efficacy of butterfly cartilage tympanoplasty for small- and medium-sized central perforations and compare it with temporalis fascia tympanoplasty. Materials and Methods: A prospective, comparative study was conducted on 110 patients, divided into two groups. Patients of tubotympanic type of chronic suppurative otitis media with 2–6 mm size perforation were included in the study. Fifty-five patients were operated by temporalis fascia Type I tympanoplasty and rest 55 by butterfly cartilage tympanoplasty (transcanal technique under local anesthesia. Results were compared in terms of pre- and post-operative air-bone gap improvement and success rates. Results: In our study, in terms of outcomes, both techniques had similar results. The success rate was 93.7% in butterfly cartilage tympanoplasty and 96.3% in temporalis fascia group. However, in terms of time taken, butterfly cartilage tympanoplasty took less time (about 30 min than temporalis fascia (about 55 min. Conclusion: Transcanal butterfly cartilage tympanoplasty is a very good alternative in small- and medium-sized perforations for conventional temporalis fascia tympanoplasty as it is simple, takes less time, day care procedure, on table hearing improvement, cosmetically no postoperative scar, no need of post aural preparation, and patient can go home within hours.

  2. Debt Shifting and Thin-Capitalization Rules – German Experience and Alternative Approaches

    Directory of Open Access Journals (Sweden)

    Ruf Martin

    2015-09-01

    Full Text Available This paper presents the general design of thin-capitalization rules and summarizes the economic effects of such rules as identified in theoretical models. We review empirical studies providing evidence on the experience with (German thin-capitalization rules as well as on the adjustment of German multinationals to foreign thin-capitalization rules. Special emphasis is given to the development in Germany, because Germany went a long way in limiting interest deductibility by enacting a drastic change in its thin-capitalization rules in 2008, and because superb German data on multinational finance allows for testing several aspects consistently. We then discuss the experience of the Nordic countries with thin-capitalization rules. Briefly reviewing potential alternatives as well, we believe that the arm’s-length principle is administratively too costly and impracticable, whereas we argue that controlled-foreign-company rules might be another promising avenue for limiting internal debt shifting. Fundamental tax reforms towards a system with either "allowance for corporate equity" (ACE or a "comprehensive business income tax" (CBIT should also eliminate any thin-capitalization incentive.

  3. Supercritical fluid extraction of meat lipids: an alternative approach to the identification of irradiated meats

    International Nuclear Information System (INIS)

    Ionizing radiation is currently under study as an alternative method for extending the shelf life of meats and meat products. Accordingly, methods are needed to determine if a meat or meat product has been exposed to ionizing radiation. In this study, a method is described for the isolation and analysis of volatile hydrocarbons formed in meat lipids after exposure to ionizing radiation. The method is based on supercritical fluid extraction of the hydrocarbons from meat lipids and subsequent identification and quantitation of individual hydrocarbons by gas chromatography (GC) with a mass selection detector (MSD). Supercritical carbon dioxide at 175 bar and 40°C extracted the hydrocarbon fraction from total meat lipids within 20 min. The presence of radiolytic hydrocarbons, as determined by GC/MSD, was then correlated to the degree of irradiation of the meat from 0 to 10 kGy. Besides being faster, this method has the advantage of reduced solvent consumption when compared to current methods for determining if a meat or meat product has been irradiated

  4. FORECASTING CHINA'S FOREIGN TRADE VOLUME WITH A KERNEL-BASED HYBRID EC-ONOMETRIC-AI ENSEMBLE LEARNING APPROACH

    Institute of Scientific and Technical Information of China (English)

    Lean YU; Shouyang WANG; Kin Keung LAI

    2008-01-01

    Due to the complexity of economic system and the interactive effects between all kinds of economic variables and foreign trade, it is not easy to predict foreign trade volume. However, the difficulty in predicting foreign trade volume is usually attributed to the limitation of many conventional forecasting models. To improve the prediction performance, the study proposes a novel kernel-based ensemble learning approach hybridizing econometric models and artificial intelligence (AI) models to predict China's foreign trade volume. In the proposed approach, an important econometric model, the co-integration-based error correction vector auto-regression (EC-VAR) model is first used to capture the impacts of all kinds of economic variables on Chinese foreign trade from a multivariate linear anal-ysis perspective. Then an artificial neural network (ANN) based EC-VAR model is used to capture the nonlinear effects of economic variables on foreign trade from the nonlinear viewpoint. Subsequently, for incorporating the effects of irregular events on foreign trade, the text mining and expert's judgmental adjustments are also integrated into the nonlinear ANN-based EC-VAR model. Finally, all kinds of economic variables, the outputs of linear and nonlinear EC-VAR models and judgmental adjustment model are used as input variables of a typical kernel-based support vector regression (SVR) for en-semble prediction purpose. For illustration, the proposed kernel-based ensemble learning methodology hybridizing econometric techniques and AI methods is applied to China's foreign trade volume predic-tion problem. Experimental results reveal that the hybrid econometric-AI ensemble learning approach can significantly improve the prediction performance over other linear and nonlinear models listed in this study.

  5. Alternative policy impacts on US GHG emissions and energy security: A hybrid modeling approach

    International Nuclear Information System (INIS)

    This study addresses the possible impacts of energy and climate policies, namely corporate average fleet efficiency (CAFE) standard, renewable fuel standard (RFS) and clean energy standard (CES), and an economy wide equivalent carbon tax on GHG emissions in the US to the year 2045. Bottom–up and top–down modeling approaches find widespread use in energy economic modeling and policy analysis, in which they differ mainly with respect to the emphasis placed on technology of the energy system and/or the comprehensiveness of endogenous market adjustments. For this study, we use a hybrid energy modeling approach, MARKAL–Macro, that combines the characteristics of two divergent approaches, in order to investigate and quantify the cost of climate policies for the US and an equivalent carbon tax. The approach incorporates Macro-economic feedbacks through a single sector neoclassical growth model while maintaining sectoral and technological detail of the bottom–up optimization framework with endogenous aggregated energy demand. Our analysis is done for two important objectives of the US energy policy: GHG reduction and increased energy security. Our results suggest that the emission tax achieves results quite similar to the CES policy but very different results in the transportation sector. The CAFE standard and RFS are more expensive than a carbon tax for emission reductions. However, the CAFE standard and RFS are much more efficient at achieving crude oil import reductions. The GDP losses are 2.0% and 1.2% relative to the base case for the policy case and carbon tax. That difference may be perceived as being small given the increased energy security gained from the CAFE and RFS policy measures and the uncertainty inherent in this type of analysis. - Highlights: • Evaluates US impacts of three energy/climate policies and a carbon tax (CT) • Analysis done with bottom–up MARKAL model coupled with a macro model • Electricity clean energy standard very close to

  6. Alternative Approach to the Provision of the High-field Dipole for FCC-hh

    CERN Document Server

    AUTHOR|(SzGeCERN)435046

    2015-01-01

    This paper describes a possible approach to reducing the complexity and cost of the high field dipole magnets. In addition the cooling of the winding could be improved in the proposed design, with a consequent reduction in the shielding requirements. The correction of multipoles is also addressed: this feature may impact on the dynamic range of operation of the magnets. Noting that it would be possible to add a small gradient component to the dipole, it is suggested that a (partially) combined function lattice should be considered. The proposals lead to a brief re-appraisal of how best to apply superconductivity to magnets for large accelerators.

  7. Late-life brain volume: a life-course approach. The AGES-Reykjavik study.

    Science.gov (United States)

    Muller, Majon; Sigurdsson, Sigurdur; Kjartansson, Olafur; Gunnarsdottir, Ingibjorg; Thorsdottir, Inga; Harris, Tamara B; van Buchem, Mark; Gudnason, Vilmundur; Launer, Lenore J

    2016-05-01

    The "fetal-origins-of-adult-disease" hypothesis proposes that an unfavorable intrauterine environment, estimated from small birth size, may induce permanent changes in fetal organs, including the brain. These changes in combination with effects of (cardiovascular) exposures during adult life may condition the later risk of brain atrophy. We investigated the combined effect of small birth size and mid-life cardiovascular risk on late-life brain volumes. Archived birth records of weight and height were abstracted for 1348 participants of the age, gene/environment susceptibility-Reykjavik study (RS; 2002-2006) population-based cohort, who participated in the original cohort of the RS (baseline 1967). Mid-life cardiovascular risk factors (CVRF) were collected in the RS. As a part of the late-life age, gene/environment susceptibility-RS examination, a brain magnetic resonance imaging was acquired and from it, volumes of total brain, gray matter, white matter, and white matter lesions were estimated. Adjusting for intracranial volume, demographics, and education showed small birth size (low ponderal index [PI]) and increased mid-life cardiovascular risk had an additive effect on having smaller late-life brain volumes. Compared with the reference group (high PI/absence of mid-life CVRF), participants with lower PI/presence of mid-life CVRF (body mass index >25 kg/m(2), hypertension, diabetes, "ever smokers") had smaller total brain volume later in life; B (95% confidence interval) were -10.9 mL (-21.0 to -0.9), -10.9 mL (-20.4 to -1.4), -20.9 mL (-46.9 to 5.2), and -10.8 mL (-19.3 to -2.2), respectively. These results suggest that exposure to an unfavorable intrauterine environment contributes to the trajectory toward smaller brain volume, adding to the atrophy that may be associated with mid-life cardiovascular risk. PMID:27103521

  8. Alternative theoretical and methodological approaches for exploring higher education in Art and Crafts

    Directory of Open Access Journals (Sweden)

    Marte Sørebø Gulliksen

    2009-12-01

    Full Text Available This article presents and discusses approaches for exploring higher education in Art and Crafts. The concepts exploring versus research and the different foci in an insider perspective versus an outsider perspective introduces the theme. An insider perspective is said to be a useful starting point for inquiry, referring to Frayling’s trichotomy research into, research on and research through from 1993. The field of higher education in Art and Crafts education is shortly presented as comprising two main areas of knowledge: knowledge of education, and knowledge about the different subject areas within Art and Crafts. Both theory and practice are a part of these areas of knowledge. As higher education in Art and Crafts is a making profession, the most prominent challenge when exploring this today is thus said to be to develop research based knowledge on Education in Art and Crafts as a making discipline.  Two keywords are deemed to be useful in approaching this theme: Mode 2 knowledge production and transdisciplinarity. The article concludes with describing specific ways of doing this today from within the context of application. Two examples of large research projects in Scandinavia are presented as examples of such projects.

  9. A volume-amending method to improve mass conservation of level set approach for incompressible two-phase flows

    Institute of Scientific and Technical Information of China (English)

    LI XiangYang; WANG YueFa; YU GengZhi; YANG Chao; MAO ZaiSha

    2008-01-01

    A volume-amending method is developed both to keep the level set function as an algebraic distance function and to preserve the bubble mass in a level set approach for incompressible two-phase flows with the significantly deformed free interface. After the traditional reinitialization procedure, a vol-ume-amending method is added for correcting the position of the interface according to mass loss/gain error until the mass error falls in the allowable range designated in advance. The level set approach with this volume-amending method incorporated has been validated by three test cases: the motion of a single axisymmetrical bubble or drop in liquid, the motion of a two-dimensional water drop falling through the air into a water pool, and the interactional motion of two buoyancy-driven three-dimensional deformable bubbles. The computational results with this volume-amending method in-corporated are in good agreement with the reported experimental data and the mass is well preserved in all cases.

  10. Evaluation of a Novel Approach for Automatic Volume Determination of Glioblastomas Based on Several Manual Expert Segmentations

    CERN Document Server

    Egger, Jan; Kuhnt, Daniela; Carl, Barbara; Kappus, Christoph; Freisleben, Bernd; Nimsky, Christopher

    2011-01-01

    The glioblastoma multiforme is the most common malignant primary brain tumor and is one of the highest malignant human neoplasms. During the course of disease, the evaluation of tumor volume is an essential part of the clinical follow-up. However, manual segmentation for acquisition of tumor volume is a time-consuming process. In this paper, a new approach for the automatic segmentation and volume determination of glioblastomas (glioblastoma multiforme) is presented and evaluated. The approach uses a user-defined seed point inside the glioma to set up a directed 3D graph. The nodes of the graph are obtained by sampling along rays that are sent through the surface points of a polyhedron. After the graph has been constructed, the minimal s-t cut is calculated to separate the glioblastoma from the background. For evaluation, 12 Magnetic Resonance Imaging (MRI) data sets were manually segmented slice by slice, by neurosurgeons with several years of experience in the resection of gliomas. Afterwards, the manual se...

  11. A volume-amending method to improve mass conservation of level set approach for incompressible two-phase flows

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A volume-amending method is developed both to keep the level set function as an algebraic distance function and to preserve the bubble mass in a level set approach for incompressible two-phase flows with the significantly deformed free interface. After the traditional reinitialization procedure, a vol-ume-amending method is added for correcting the position of the interface according to mass loss/gain error until the mass error falls in the allowable range designated in advance. The level set approach with this volume-amending method incorporated has been validated by three test cases: the motion of a single axisymmetrical bubble or drop in liquid, the motion of a two-dimensional water drop falling through the air into a water pool, and the interactional motion of two buoyancy-driven three- dimensional deformable bubbles. The computational results with this volume-amending method in-corporated are in good agreement with the reported experimental data and the mass is well preserved in all cases.

  12. A practical approach to volume minimisation of low level radioactive waste at UKAEA, Winfrith

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, A.; Hawkins, G.; Milverton, P. [UKAEA, Solid Waste Services Section, Winfrith Technology Centre, Dorchester, Dorset (United Kingdom)

    2003-07-01

    To fulfil the United Kingdom Atomic Energy Authority (UKAEA) policy on best practicable environmental option (BPEO), the requirements of the radioactive substances act (RSA) 1993 and to meet the BNFL Drigg Conditions of Acceptance, the UKAEA Winfrith employ a range of techniques to minimise the volume of low level radioactive waste (LLW) consigned to BNFL drigg for final disposal. To achieve this the UKAEA Winfrith solid waste services section commissioned a plasma cutting facility, a lead decontamination facility and the Winfrith abrasive cleaning machine (WACM). These techniques coupled with regular supercompaction campaigns and a free release procedure ensure UKAEA Winfrith minimise the volume of LLW consigned to BNFL Drigg. This paper describes the waste minimisation techniques, the supercompaction campaigns and the free release monitoring programme employed at UKAEA Winfrith. (orig.)

  13. A practical approach to volume minimisation of low level radioactive waste at UKAEA, Winfrith

    International Nuclear Information System (INIS)

    To fulfil the United Kingdom Atomic Energy Authority (UKAEA) policy on best practicable environmental option (BPEO), the requirements of the radioactive substances act (RSA) 1993 and to meet the BNFL Drigg Conditions of Acceptance, the UKAEA Winfrith employ a range of techniques to minimise the volume of low level radioactive waste (LLW) consigned to BNFL drigg for final disposal. To achieve this the UKAEA Winfrith solid waste services section commissioned a plasma cutting facility, a lead decontamination facility and the Winfrith abrasive cleaning machine (WACM). These techniques coupled with regular supercompaction campaigns and a free release procedure ensure UKAEA Winfrith minimise the volume of LLW consigned to BNFL Drigg. This paper describes the waste minimisation techniques, the supercompaction campaigns and the free release monitoring programme employed at UKAEA Winfrith. (orig.)

  14. Constrained reaction volume approach for studying chemical kinetics behind reflected shock waves

    KAUST Repository

    Hanson, Ronald K.

    2013-09-01

    We report a constrained-reaction-volume strategy for conducting kinetics experiments behind reflected shock waves, achieved in the present work by staged filling in a shock tube. Using hydrogen-oxygen ignition experiments as an example, we demonstrate that this strategy eliminates the possibility of non-localized (remote) ignition in shock tubes. Furthermore, we show that this same strategy can also effectively eliminate or minimize pressure changes due to combustion heat release, thereby enabling quantitative modeling of the kinetics throughout the combustion event using a simple assumption of specified pressure and enthalpy. We measure temperature and OH radical time-histories during ethylene-oxygen combustion behind reflected shock waves in a constrained reaction volume and verify that the results can be accurately modeled using a detailed mechanism and a specified pressure and enthalpy constraint. © 2013 The Combustion Institute.

  15. Equilibrium energy spread and emittance in a Compton ring: An alternative approach

    Science.gov (United States)

    Chaikovska, I.; Variola, A.

    2014-04-01

    In this article the Campbell's theorem is used to evaluate the equilibrium emittance and energy spread in a Compton ring. This method allows us to have an efficient analytical approach separating the contributions of the Compton cross section from the luminosity factor. The consequent advantage is given by the possibility to have an easy extrapolation for the "nonclassical" cases like the polarized Compton backscattering or the evaluation of the equilibrium given by different radiation mechanisms. The effects accounting for the polarized Compton backscattering in the article are evaluated numerically. The analytical results in the nonpolarized case and in the negligible recoil effect approximation are in excellent agreement with the values obtained by matching the Compton damping rate with the quantum fluctuations, and they show that the equilibrium energy spread and emittance are independent from the luminosity.

  16. Permeability estimation for heavy oil reservoir: an alternative approach to avoid misleading tendencies

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, L. [PDVSA (Venezuela)

    2011-07-01

    In oil production, characterization of the reservoir has to be undertaken in order to optimize the hydrocarbon production rate. Permeability is one of the most important parameters of a reservoir but estimation is difficult in heavy oil reservoirs and requires the use of multiple techniques. The objective of this paper was to evaluate the results of implementing a multi-scale permeability estimation method. Scale support effect and the physics of the measurements were looked into through a study which was conducted in Venezuela on two of PDVSA's fields, the Cerro Negro Field and the Morichal Field. Results showed that the proposed methodology captured efficiently the influence of parameters on permeability production and was successful in removing the local bias from the permeability data. The multi scale permeability estimation methodology was shown to address the issues encountered with a unique approach and to provide excellent results.

  17. Flux-Averaged and Volume-Averaged Concentrations in Continuum Approaches to Solute Transport

    Science.gov (United States)

    Parker, J. C.; van Genuchten, M. Th.

    1984-07-01

    Transformations between volume-averaged pore fluid concentrations and flux-averaged concentrations are presented which show that both modes of concentration obey convective-dispersive transport equations of identical mathematical form for nonreactive solutes. The pertinent boundary conditions for the two modes, however, do not transform identically. Solutions of the convection-dispersion equation for a semi-infinite system during steady flow subject to a first-type inlet boundary condition is shown to yield flux concentrations, while solutions subject to a third-type boundary condition yield volume-averaged concentrations. These solutions may be applied with reasonable impunity to finite as well as semi-infinite media if back mixing at the exit is precluded. Implications of the distinction between resident and flux concentrations to laboratory and field studies of solute transport are discussed. It is suggested that perceived limitations of the convection-dispersion model for media with large variations in pore water velocities may in certain cases be attributable to a failure to distinguish between volume-averaged and flux-averaged concentrations.

  18. New opportunities and proven approaches in complementary and alternative medicine research at the National Institutes of Health.

    Science.gov (United States)

    Harlan, W R

    2001-01-01

    This presentation describes some of the issues that arise when applying the clinical-trial approach of conventional medicine to complementary and alternative medicine (CAM) modalities. Conventional medicine has been making the evolution to using an evidence base and to making recommendations only when the evidence is strong. The National Center for Complementary Medicine (NCCAM), one of twenty-five Institutes or Centers of the National Institutes of Health (NIH), is working to hold CAM to the same high standards, not by rejecting previous CAM research, but by building on that strong evidence base of what works and what is safe. The process for conventional drug and device development follows an orderly process of preclinical studies (usually on animals), phase I, phase II, and phase III studies (with the large human clinical trial phase taking place in phase III). Today, the randomized controlled trial is recognized as providing the highest level of scientific evidence. This conventional medicine approach to development is now being used to develop complementary and alternative therapies. For instance, the discovery and development of Taxol (Bristol-Meyers Squibb, New York, NY), an extract from the bark of the Pacific yew tree that is now a widely used chemotherapeutic agent, followed the conventional pathway to approval and marketing. But for most CAM products, the pathway is not so straightforward. Most CAM therapies are traditional therapies or new products that are already available to the public. Most of what is known about these therapies is of an anecdotal nature. There has been little isolation of the active principals from the crude product and there has usually been no preclinical testing. This presentation details various approaches and programs that address how to plan and conduct a rigorous clinical trial of a CAM product. And, while it takes a good deal of persistence and a strong focus on what are the critical principals in a trial, I conclude that

  19. Reflection on the possibility of alternative approach to the psychopathology of “functional” disorders

    Directory of Open Access Journals (Sweden)

    Jerzy W. Aleksandrowicz

    2016-05-01

    Full Text Available Functional short-term disorders provoked by extremely difficult life events – stresses – are entirely different from the chronic or recurrent ones: anxiety or other “neurotic” syndromes, eating, sexual and some other disorders, not being conditioned behavioral dysfunctions. Chronic/ recurrent disorders seems to have they causes in the particular personality traits and deficits. Some of them are revealed, described and could be measured by means of Neurotic Personality Questionnaire KON 2006. In this approach, functional disorder is understood as structured systems of the particular nonverbal language (“parole” in which symptoms play a role of words while syndromes the role of sentences, expressing the current state of mind – mainly the need of bond with other people and its frustration. They are messages of looking attention, attachment. The use of such language seems to be the result of personality deficits making difficult or even impossible to fulfil the need of bond in the psychosocial field using common for done culture verbal and nonverbal language, “normal” means of communication. While in the acute and conditioned reactions on stress different forms of helping people (e.g. CBT seems to be adequate, in the chronic and recurrent functional disorders therapy is postulated to aiming rather at transformations of the communication, leading to the exchange of the messages’ language having the quality of disorder for common, mainly verbal one.

  20. Modeling noise-induced resonance in an excitable system: an alternative approach.

    Science.gov (United States)

    Nurujjaman, Md

    2010-03-01

    Recently, it has been observed [Md. Nurujjaman, Phy. Rev. E 80, 015201(R) (2009)] that in an excitable system, one can maintain noise-induced coherency in the coherence resonance by blocking the destructive effect of the noise on the system at higher noise level. This phenomenon of constant coherence resonance (CCR) cannot be explained by the existing way of simulation of the model equations of an excitable system with added noise. In this paper, we have proposed a general model which explains the noise-induced resonance phenomenon CCR as well as coherence resonance (CR) and stochastic resonance (SR). The simulation has been carried out considering the basic mechanism of noise-induced resonance phenomena: noise only perturbs the system control parameter to excite coherent oscillations, taking proper precautions so that the destructive effect of noise does not affect the system. In this approach, the CR has been obtained from the interference between the system output and noise and the SR has been obtained by adding noise and a subthreshold signal. This also explains the observation of the frequency shift of coherent oscillations in the CCR with noise level.

  1. Alternatives to relational database: comparison of NoSQL and XML approaches for clinical data storage.

    Science.gov (United States)

    Lee, Ken Ka-Yin; Tang, Wai-Choi; Choi, Kup-Sze

    2013-04-01

    Clinical data are dynamic in nature, often arranged hierarchically and stored as free text and numbers. Effective management of clinical data and the transformation of the data into structured format for data analysis are therefore challenging issues in electronic health records development. Despite the popularity of relational databases, the scalability of the NoSQL database model and the document-centric data structure of XML databases appear to be promising features for effective clinical data management. In this paper, three database approaches--NoSQL, XML-enabled and native XML--are investigated to evaluate their suitability for structured clinical data. The database query performance is reported, together with our experience in the databases development. The results show that NoSQL database is the best choice for query speed, whereas XML databases are advantageous in terms of scalability, flexibility and extensibility, which are essential to cope with the characteristics of clinical data. While NoSQL and XML technologies are relatively new compared to the conventional relational database, both of them demonstrate potential to become a key database technology for clinical data management as the technology further advances. PMID:23177219

  2. Murine fundus fluorescein angiography: An alternative approach using a handheld camera.

    Science.gov (United States)

    Ehrenberg, Moshe; Ehrenberg, Scott; Schwob, Ouri; Benny, Ofra

    2016-07-01

    In today's modern pharmacologic approach to treating sight-threatening retinal vascular disorders, there is an increasing demand for a compact, mobile, lightweight and cost-effective fluorescein fundus camera to document the effects of antiangiogenic drugs on laser-induced choroidal neovascularization (CNV) in mice and other experimental animals. We have adapted the use of the Kowa Genesis Df Camera to perform Fundus Fluorescein Angiography (FFA) in mice. The 1 kg, 28 cm high camera has built-in barrier and exciter filters to allow digital FFA recording to a Compact Flash memory card. Furthermore, this handheld unit has a steady Indirect Lens Holder that firmly attaches to the main unit, that securely holds a 90 diopter lens in position, in order to facilitate appropriate focus and stability, for photographing the delicate central murine fundus. This easily portable fundus fluorescein camera can effectively record exceptional central retinal vascular detail in murine laser-induced CNV, while readily allowing the investigator to adjust the camera's position according to the variable head and eye movements that can randomly occur while the mouse is optimally anesthetized. This movable image recording device, with efficiencies of space, time, cost, energy and personnel, has enabled us to accurately document the alterations in the central choroidal and retinal vasculature following induction of CNV, implemented by argon-green laser photocoagulation and disruption of Bruch's Membrane, in the experimental murine model of exudative macular degeneration. PMID:27260483

  3. Truncated conformal space approach in d dimensions a Cheap Alternative to the Lattice?

    CERN Document Server

    Hogervorst, Matthijs; van Rees, Balt C

    2015-01-01

    We show how to perform accurate, nonperturbative and controlled calculations in quantum field theory in d dimensions. We use the Truncated Conformal Space Approach (TCSA), a Hamiltonian method which exploits the conformal structure of the UV fixed point. The theory is regulated in the IR by putting it on a sphere of a large finite radius. The QFT Hamiltonian is expressed as a matrix in the Hilbert space of CFT states. After restricting ourselves to energies below a certain UV cutoff, an approximation to the spectrum is obtained by numerical diagonalization of the resulting finite-dimensional matrix. The cutoff dependence of the results can be computed and efficiently reduced via a renormalization procedure. We work out the details of the method for the phi^4 theory in d dimensions with d not necessarily integer. A numerical analysis is then performed for the specific case d = 2.5, a value chosen in the range where UV divergences are absent. By going from weak to intermediate to strong coupling, we are able to...

  4. Solution calorimetry as an alternative approach for dissolution testing of nanosuspensions.

    Science.gov (United States)

    Kayaert, P; Li, B; Jimidar, I; Rombaut, P; Ahssini, F; Van den Mooter, G

    2010-11-01

    The formulation of poorly soluble drugs as nanocrystals/nanosuspensions has rapidly evolved during the past decade into a mature drug-delivery strategy. The major characteristic of these systems is the high drug dissolution rate, enabling bioavailability enhancement after oral administration. It is therefore of great importance to have access to analytical methodology that is able to accurately monitor the extreme fast dissolution process of such formulations. The aim of the present study was to evaluate solution calorimetry as a novel approach to measure the dissolution rate of nanosuspensions by recording the temperature change in the dissolution vessel during the dissolution process of the nanocrystals. The applicability was tested on different nanosuspensions made up of three model drugs: naproxen, cinnarizine and an investigational API, i.e. compound A. The dissolution process of all nanosuspensions investigated was completed within less than 1 min. During this period, sufficient data points were collected to transform temperature offset data to cumulative heat of solution pointing to the potential of this technique. However, of significant concern is the fact that this technique measures the total heat produced or consumed by all processes that occur during the dissolution, e.g. the heat of mixing when the nanosuspension comes in contact with the dissolution medium. Erroneous conclusions will result if phenomena other than dissolution are not accounted for. PMID:20887787

  5. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation.

    Science.gov (United States)

    Langdon, Amy; Crook, Nathan; Dantas, Gautam

    2016-04-13

    The widespread use of antibiotics in the past 80 years has saved millions of human lives, facilitated technological progress and killed incalculable numbers of microbes, both pathogenic and commensal. Human-associated microbes perform an array of important functions, and we are now just beginning to understand the ways in which antibiotics have reshaped their ecology and the functional consequences of these changes. Mounting evidence shows that antibiotics influence the function of the immune system, our ability to resist infection, and our capacity for processing food. Therefore, it is now more important than ever to revisit how we use antibiotics. This review summarizes current research on the short-term and long-term consequences of antibiotic use on the human microbiome, from early life to adulthood, and its effect on diseases such as malnutrition, obesity, diabetes, and Clostridium difficile infection. Motivated by the consequences of inappropriate antibiotic use, we explore recent progress in the development of antivirulence approaches for resisting infection while minimizing resistance to therapy. We close the article by discussing probiotics and fecal microbiota transplants, which promise to restore the microbiota after damage of the microbiome. Together, the results of studies in this field emphasize the importance of developing a mechanistic understanding of gut ecology to enable the development of new therapeutic strategies and to rationally limit the use of antibiotic compounds.

  6. An alternative approach for choice models in transportation: Use of possibility theory for comparison of utilities

    Directory of Open Access Journals (Sweden)

    Dell’orco Mauro

    2004-01-01

    Full Text Available Modeling of human choice mechanism has been a topic of intense discussion in the transportation community for many years. The framework of modeling has been rooted in probability theory in which the analyst’s uncertainty about the integrity of the model is expressed in probability. In most choice situations, the decision-maker (traveler also experiences uncertainty because of the lack of complete information on the choices. In the traditional modeling framework, the uncertainty of the analyst and that of the decision-maker are both embedded in the same random term and not clearly separated. While the analyst's uncertainty may be represented by probability due to the statistical nature of events, that of the decision maker, however, is not always subjected to randomness; rather, it is the perceptive uncertainty. This paper proposes a modeling framework that attempts to account for the decision maker’s uncertainty by possibility theory and then the analyst's uncertainty by probability theory. The possibility to probability transformation is performed using the principle of uncertainty invariance. The proposed approach accounts for the quality of information on the changes in choice probability. The paper discusses the thought process, mathematics of possibility theory and probability transformation, and examples.

  7. Bioacoustics of human whistled languages: an alternative approach to the cognitive processes of language

    Directory of Open Access Journals (Sweden)

    Meyer Julien

    2004-01-01

    Full Text Available Whistled languages are a valuable heritage of human culture. This paper gives a first survey about a new multidisciplinary approach to these languages. Previous studies on whistled equivalents of languages have already documented that they can provide significant information about the role of rhythm and melody in language. To substantiate this, most whistles are represented by modulations of frequency, centered around 2000 Hz (±1000 Hz and often reach a loudness of about 130 dB (measured at 1m from the source. Their transmission range can reach up to 10 km (as verified in La Gomera, Canary Island, and the messages can remain understandable, even if the signal is deteriorated. In some cultures the use of whistled language is associated with some "talking musical instruments" (e.g. flutes, guitars, harps, gongs, drums, khens. Finally, whistles as a means of conveying information have some analogues in the animal kingdom (e.g. some birds, cetaceans, primates, providing opportunities to compare the acoustic characteristics of the respective signals. With such properties as a reference, the project reported here has two major tasks: to further elucidate the many facets of whistled language and, above all, help to immediately stop the process of its gradual disappearance.

  8. Bioacoustics of human whistled languages: an alternative approach to the cognitive processes of language.

    Science.gov (United States)

    Meyer, Julien

    2004-06-01

    Whistled languages are a valuable heritage of human culture. This paper gives a first survey about a new multidisciplinary approach to these languages. Previous studies on whistled equivalents of languages have already documented that they can provide significant information about the role of rhythm and melody in language. To substantiate this, most whistles are represented by modulations of frequency, centered around 2000 Hz (+/- 1000 Hz) and often reach a loudness of about 130 dB (measured at 1m from the source). Their transmission range can reach up to 10 km (as verified in La Gomera, Canary Island), and the messages can remain understandable, even if the signal is deteriorated. In some cultures the use of whistled language is associated with some "talking musical instruments" (e.g. flutes, guitars, harps, gongs, drums, khens). Finally, whistles as a means of conveying information have some analogues in the animal kingdom (e.g. some birds, cetaceans, primates), providing opportunities to compare the acoustic characteristics of the respective signals. With such properties as a reference, the project reported here has two major tasks: to further elucidate the many facets of whistled language and, above all, help to immediately stop the process of its gradual disappearance.

  9. Art and architecture as experience: an alternative approach to bridging art history and the neurosciences.

    Science.gov (United States)

    Zschocke, Nina

    2012-08-01

    In 1972, Michael Baxandal characterizes the processes responsible for the cultural relativism of art experience as highly complex and unknown in their physiological detail. While art history still shows considerable interest in the brain sciences forty years later, most cross-disciplinary studies today are referring to the neurosciences in an attempt to seek scientific legitimization of variations of a generalized and largely deterministic model of perception, reducing interaction between a work of art and its observers to a set of biological automatisms. I will challenge such an approach and take up art theory's interest in the historico-cultural and situational dimensions of art experience. Looking at two examples of large-scale installation and sculptural post-war American art, I will explore instable perceptions of depth and changing experiences of space that indicate complex interactions between perceptual and higher cognitive processes. The argument will draw on recent theories describing neuronal processes underlying multistable phenomena, eye movement, visual attention and decision-making. As I will show a large number of neuroscientific studies provide theoretical models that help us analyse not the anthropological constants but the influence of cultural, individual and situational variables on aesthetic experience.

  10. Murine fundus fluorescein angiography: An alternative approach using a handheld camera.

    Science.gov (United States)

    Ehrenberg, Moshe; Ehrenberg, Scott; Schwob, Ouri; Benny, Ofra

    2016-07-01

    In today's modern pharmacologic approach to treating sight-threatening retinal vascular disorders, there is an increasing demand for a compact, mobile, lightweight and cost-effective fluorescein fundus camera to document the effects of antiangiogenic drugs on laser-induced choroidal neovascularization (CNV) in mice and other experimental animals. We have adapted the use of the Kowa Genesis Df Camera to perform Fundus Fluorescein Angiography (FFA) in mice. The 1 kg, 28 cm high camera has built-in barrier and exciter filters to allow digital FFA recording to a Compact Flash memory card. Furthermore, this handheld unit has a steady Indirect Lens Holder that firmly attaches to the main unit, that securely holds a 90 diopter lens in position, in order to facilitate appropriate focus and stability, for photographing the delicate central murine fundus. This easily portable fundus fluorescein camera can effectively record exceptional central retinal vascular detail in murine laser-induced CNV, while readily allowing the investigator to adjust the camera's position according to the variable head and eye movements that can randomly occur while the mouse is optimally anesthetized. This movable image recording device, with efficiencies of space, time, cost, energy and personnel, has enabled us to accurately document the alterations in the central choroidal and retinal vasculature following induction of CNV, implemented by argon-green laser photocoagulation and disruption of Bruch's Membrane, in the experimental murine model of exudative macular degeneration.

  11. Bioacoustics of human whistled languages: an alternative approach to the cognitive processes of language.

    Science.gov (United States)

    Meyer, Julien

    2004-06-01

    Whistled languages are a valuable heritage of human culture. This paper gives a first survey about a new multidisciplinary approach to these languages. Previous studies on whistled equivalents of languages have already documented that they can provide significant information about the role of rhythm and melody in language. To substantiate this, most whistles are represented by modulations of frequency, centered around 2000 Hz (+/- 1000 Hz) and often reach a loudness of about 130 dB (measured at 1m from the source). Their transmission range can reach up to 10 km (as verified in La Gomera, Canary Island), and the messages can remain understandable, even if the signal is deteriorated. In some cultures the use of whistled language is associated with some "talking musical instruments" (e.g. flutes, guitars, harps, gongs, drums, khens). Finally, whistles as a means of conveying information have some analogues in the animal kingdom (e.g. some birds, cetaceans, primates), providing opportunities to compare the acoustic characteristics of the respective signals. With such properties as a reference, the project reported here has two major tasks: to further elucidate the many facets of whistled language and, above all, help to immediately stop the process of its gradual disappearance. PMID:15258658

  12. An alternative approach to analyze Ipsative data. Revisiting Experiential Learning Theory

    Directory of Open Access Journals (Sweden)

    Joan Manuel eBatista-Foguet

    2015-11-01

    Full Text Available The ritualistic use of statistical models regardless of the type of data actually available is a common practice across disciplines. Statistical models involve a series of assumptions whose existence is often neglected altogether, thus making the mentioned common practice even more pervasive. This paper illustrates the consequences of this ritualistic practice within Kolb’s Experiential Learning Theory (ELT operationalized through its Learning Style Inventory (KLSI. We show how using a well-known methodology in other disciplines -compositional data analysis (CODA- KLSI data can be properly analyzed. In addition, a third dimension of the KLSI is unveiled providing room for future research. This third dimension describes an individual’s relative preference for learning by prehension rather than by transformation. Using a sample of European MBA students, we relate this dimension with another self-assessment instrument, the Philosophical Orientation Questionnaire (POQ, and with an observer-assessed instrument, the Emotional and Social Inventory (ESCI-U. Both show plausible statistical relationships. An intellectual operating philosophy is linked to a preference for prehension, whereas a pragmatic operating philosophy is linked to transformation. Self-management and social awareness competencies are linked to a learning preference for transforming knowledge, whereas relationship management and cognitive competencies are more related to approaching learning by prehension.

  13. Education and microfinance: an alternative approach to the empowerment of the poor people in Indonesia.

    Science.gov (United States)

    Hadi, Rizali; Wahyudin, Uyu; Ardiwinata, Jajat S; Abdu, Wamaungo Juma

    2015-01-01

    There is good reason to combine education with microcredit for poverty alleviation in the poor communities of the developing world, including in Indonesia. Poverty is dangerous, it deprives people of their right to education, their right to good health, their right to freedom of speech, their right to democracy, their right to financial services and of course their right to knowledge enhancement, which are all crucial to living a better life. We must therefore, provide services beyond, credits for the poor. In this case, education should be included to each and every development agenda for the poor since it is key to any positive change and sustainable development of people. If well planned and well integrated within the microcredit services, education can serve a good purpose in poverty alleviation. This paper describes how education and microfinance have been used in combination to alleviate poverty in Indonesia, especially in the areas studied. The study uses a multi-cases approach to examine the purposively selected baitul maal tamwil (BMTs) organisations, which are sharia based semiformal microfinance institutions regarded to be among those few integrating education with their financial services. PMID:26085974

  14. Reducing Uncertainty In Ecosystem Structure Inventories From Spaceborne Lidar Using Alternate Spatial Sampling Approaches

    Science.gov (United States)

    Lefsky, M. A.; Ramond, T.; Weimer, C. S.

    2010-12-01

    Current and proposed spaceborne lidar sensors sample the land surface using observations along transects in which consecutive observations in the along-track dimension are either contiguous (e.g. VCL, DESDynI, Livex) or spaced (ICESat). These sampling patterns are inefficient because multiple observations are made of a spatially autocorrelated phenomenon (i.e. vegetation patches) while large areas of the landscape are left un-sampled. This results in higher uncertainty in estimates of average ecosystem structure than would be obtained using either random sampling or sampling in regular grids. We compared three sampling scenarios for spaceborne lidar: five transects spaced every 850 m across-track with contiguous 25m footprints along-track, the same number of footprints distributed randomly, and a hybrid approach that retains the central transect of contiguous 25m footprints and distributes the remainder of the footprints into a grid with 178 m spacing. We used simulated ground tracks at four latitudes for a realistic spaceborne lidar mission and calculated the amount of time required to achieve 150 m spacing between transects and the number of near-coincident observations for each scenario. We used four lidar height datasets collected using the Laser Vegetation Imaging Sensor (La Selva, Costa Rica, Sierra Nevada, California, Duke Forest, North Carolina and Harvard Forest, Massachusetts) to calculate the standard error of estimates of landscape height for each scenario. We found that a hybrid sampling approach reduced the amount of time required to reach a transect spacing of 150 m by a factor of three at all four latitudes, and that the number of near-coincident observations was greater by a factor of five at the equator and at least equal throughout the range of latitudes sampled. The standard error of landscape height was between 2 and 2.5 times smaller using either hybrid or random sampling than using transect sampling. As the pulses generated by a spaceborne

  15. Accounting for water management issues within hydrological simulation: Alternative modelling options and a network optimization approach

    Science.gov (United States)

    Efstratiadis, Andreas; Nalbantis, Ioannis; Rozos, Evangelos; Koutsoyiannis, Demetris

    2010-05-01

    In mixed natural and artificialized river basins, many complexities arise due to anthropogenic interventions in the hydrological cycle, including abstractions from surface water bodies, groundwater pumping or recharge and water returns through drainage systems. Typical engineering approaches adopt a multi-stage modelling procedure, with the aim to handle the complexity of process interactions and the lack of measured abstractions. In such context, the entire hydrosystem is separated into natural and artificial sub-systems or components; the natural ones are modelled individually, and their predictions (i.e. hydrological fluxes) are transferred to the artificial components as inputs to a water management scheme. To account for the interactions between the various components, an iterative procedure is essential, whereby the outputs of the artificial sub-systems (i.e. abstractions) become inputs to the natural ones. However, this strategy suffers from multiple shortcomings, since it presupposes that pure natural sub-systems can be located and that sufficient information is available for each sub-system modelled, including suitable, i.e. "unmodified", data for calibrating the hydrological component. In addition, implementing such strategy is ineffective when the entire scheme runs in stochastic simulation mode. To cope with the above drawbacks, we developed a generalized modelling framework, following a network optimization approach. This originates from the graph theory, which has been successfully implemented within some advanced computer packages for water resource systems analysis. The user formulates a unified system which is comprised of the hydrographical network and the typical components of a water management network (aqueducts, pumps, junctions, demand nodes etc.). Input data for the later include hydraulic properties, constraints, targets, priorities and operation costs. The real-world system is described through a conceptual graph, whose dummy properties

  16. Testing of low-temperature stabilization alternatives for salt containing mixed wastes - Approach and results to date

    International Nuclear Information System (INIS)

    Through its annual process of identifying technology deficiencies associated with waste treatment, the Department of Energy's (DOE) Mixed Waste Focus Area (MWFA) determined that the former DOE weapons complex lacks efficient mixed waste stabilization technologies for salt containing wastes. These wastes were generated as sludge and solid effluents from various primary nuclear processes involving acids and metal finishing; and well over 10,000 cubic meters exist at 6 sites. In addition, future volumes of these problematic wastes will be produced as other mixed waste treatment methods such as incineration and melting are deployed. The current method used to stabilize salt waste for compliant disposal is grouting with Portland cement. This method is inefficient since the highly soluble and reactive chloride, nitrate, and sulfate salts interfere with the hydration and setting processes associated with grouting. The inefficiency results from having to use low waste loadings to ensure a durable and leach resistant final waste form. The following five alternatives were selected for MWFA development funding in FY97 and FY98: phosphate bonded ceramics; sol-gel process; polysiloxane; polyester resin; and enhanced concrete. Comparable evaluations were planned for the stabilization development efforts. Under these evaluations each technology stabilized the same type of salt waste surrogates. Final waste form performance data such as compressive strength, waste loading, and leachability could then be equally compared. Selected preliminary test results are provided in this paper

  17. Wildland fire management. Volume 1: Prevention methods and analysis. [systems engineering approach to California fire problems

    Science.gov (United States)

    Weissenberger, S. (Editor)

    1973-01-01

    A systems engineering approach is reported for the problem of reducing the number and severity of California's wildlife fires. Prevention methodologies are reviewed and cost benefit models are developed for making preignition decisions.

  18. Reaction of Tosylmethyl Isocyanide with N-Heteroaryl Formamidines: an Alternative Approach to the Synthesis of N-Heteroaryl Tosylimidazoles

    Energy Technology Data Exchange (ETDEWEB)

    Gomezgarcia, Omar; Salgadozamora, Hector; Reyesarellano, Aliciam; Camposaldrete, Elena; Peraltacruz, Javier [Departamento Quimica Organica, Colonia (Mexico)

    2013-09-15

    In conclusion, an alternative procedure was developed under mild conditions for the synthesis of 2-(4-tosylimidazo-1-yl)pyridines and pyrimidines by the reaction of TosMIC with the corresponding heteroaryl N,N'-dimethyl form-amidines. This approach does not involve a nucleophilic displacement of a leaving group and constitutes a further application of amidines, in which TosMIC acts as both a nucleophile and an electrophile on the heteroaryl formamidine. This process offers advantages over previously reported procedures. Tosyl methyl isocyanide (TosMIC), a multipurpose commercially available 3-unit synthon introduced by Van Leusen, reacts with a variety of groups to give heterocycles. It is important to emphasize that treatment of TosMIC with various functional groups leads to the formation of the imidazole nucleus, such as is the case with imines, imidoyl chlorides, isothiocyanates, nitrile and ethoxy methylene amino. However, only the latter group yields N-heterocycle imidazoles.

  19. An alternative to the traveling-wave approach for use in two-port descriptions of acoustic bores

    Science.gov (United States)

    Ducasse, Eric

    2002-12-01

    For more than a decade, the digital waveguide model for musical instruments has been improved through the simulation of cylindrical and conical bores. But several difficulties remain, such as instabilities due to growing exponentials which appear when two conical bores are connected with decreasing taper. In this paper, an alternative overcoming these difficulties is proposed and can be extended to shapes other than cylinders, cones, and hyperbolic horns. A two-port model with more general state variables than usual traveling waves works efficiently for any shape without discontinuities in cross section. The equations for connecting separate elements at discontinuities make this two-port model appropriate for use in time domain simulation of the physical behavior of the wind instrument and its interactions with the player. The potential of this new approach is illustrated by several detailed examples.

  20. Forecasting of exported volume for brazilian fruits by time series analysis: an arima/garch approach

    Directory of Open Access Journals (Sweden)

    Abdinardo Moreira Barreto de Oliveira

    2015-06-01

    Full Text Available The aim of this paper was to offer econometric forecasting models to the Brazilian exported volume fruits, with a view to assisting the planning and production control, also motivated by the existence of a few published papers dealing with this issue. In this sense, it was used the ARIMA/GARCH models, considering, likewise, the occurrence of a multiplicative stochastic seasonality in these series. They were collected 300 observations of exported net weight (kg between Jan/1989 and Dec/2013 of the following fruits: pineapple, banana, orange, lemon, apple, papaya, mango, watermelon, melon and grape, which selection criteria was its importance in the exported basket fruit, because they represented 97% of total received dollars, and 99% of total volume sold in 2010, of a population about 28 kinds of exported fruits. The results showed that it was not only observed the existence of a 12 month multiplicative seasonality in banana and mango. On the other hand, they were identified two fruits groups: (1 those which are continuously exported, and (2 those which have export peaks. On the quality of the models, they were considered satisfactory for six of the ten fruits analyzed. On the volatility, it was seen a high persistence in banana and papaya series, pointing to the existence of a structural break in time series, which could be linked to the economic crises happened in the last 17 years.

  1. Language acquisition for deaf children: Reducing the harms of zero tolerance to the use of alternative approaches

    Directory of Open Access Journals (Sweden)

    Humphries Tom

    2012-04-01

    Full Text Available Abstract Children acquire language without instruction as long as they are regularly and meaningfully engaged with an accessible human language. Today, 80% of children born deaf in the developed world are implanted with cochlear devices that allow some of them access to sound in their early years, which helps them to develop speech. However, because of brain plasticity changes during early childhood, children who have not acquired a first language in the early years might never be completely fluent in any language. If they miss this critical period for exposure to a natural language, their subsequent development of the cognitive activities that rely on a solid first language might be underdeveloped, such as literacy, memory organization, and number manipulation. An alternative to speech-exclusive approaches to language acquisition exists in the use of sign languages such as American Sign Language (ASL, where acquiring a sign language is subject to the same time constraints of spoken language development. Unfortunately, so far, these alternatives are caught up in an "either - or" dilemma, leading to a highly polarized conflict about which system families should choose for their children, with little tolerance for alternatives by either side of the debate and widespread misinformation about the evidence and implications for or against either approach. The success rate with cochlear implants is highly variable. This issue is still debated, and as far as we know, there are no reliable predictors for success with implants. Yet families are often advised not to expose their child to sign language. Here absolute positions based on ideology create pressures for parents that might jeopardize the real developmental needs of deaf children. What we do know is that cochlear implants do not offer accessible language to many deaf children. By the time it is clear that the deaf child is not acquiring spoken language with cochlear devices, it might already be

  2. Language acquisition for deaf children: Reducing the harms of zero tolerance to the use of alternative approaches.

    Science.gov (United States)

    Humphries, Tom; Kushalnagar, Poorna; Mathur, Gaurav; Napoli, Donna Jo; Padden, Carol; Rathmann, Christian; Smith, Scott R

    2012-01-01

    Children acquire language without instruction as long as they are regularly and meaningfully engaged with an accessible human language. Today, 80% of children born deaf in the developed world are implanted with cochlear devices that allow some of them access to sound in their early years, which helps them to develop speech. However, because of brain plasticity changes during early childhood, children who have not acquired a first language in the early years might never be completely fluent in any language. If they miss this critical period for exposure to a natural language, their subsequent development of the cognitive activities that rely on a solid first language might be underdeveloped, such as literacy, memory organization, and number manipulation. An alternative to speech-exclusive approaches to language acquisition exists in the use of sign languages such as American Sign Language (ASL), where acquiring a sign language is subject to the same time constraints of spoken language development. Unfortunately, so far, these alternatives are caught up in an "either - or" dilemma, leading to a highly polarized conflict about which system families should choose for their children, with little tolerance for alternatives by either side of the debate and widespread misinformation about the evidence and implications for or against either approach. The success rate with cochlear implants is highly variable. This issue is still debated, and as far as we know, there are no reliable predictors for success with implants. Yet families are often advised not to expose their child to sign language. Here absolute positions based on ideology create pressures for parents that might jeopardize the real developmental needs of deaf children. What we do know is that cochlear implants do not offer accessible language to many deaf children. By the time it is clear that the deaf child is not acquiring spoken language with cochlear devices, it might already be past the critical period, and

  3. Evaluation of simulation alternatives for the brute-force ray-tracing approach used in backlight design

    Science.gov (United States)

    Desnijder, Karel; Hanselaer, Peter; Meuret, Youri

    2016-04-01

    A key requirement to obtain a uniform luminance for a side-lit LED backlight is the optimised spatial pattern of structures on the light guide that extract the light. The generation of such a scatter pattern is usually performed by applying an iterative approach. In each iteration, the luminance distribution of the backlight with a particular scatter pattern is analysed. This is typically performed with a brute-force ray-tracing algorithm, although this approach results in a time-consuming optimisation process. In this study, the Adding-Doubling method is explored as an alternative way for evaluating the luminance of a backlight. Due to the similarities between light propagating in a backlight with extraction structures and light scattering in a cloud of light scatterers, the Adding-Doubling method which is used to model the latter could also be used to model the light distribution in a backlight. The backlight problem is translated to a form upon which the Adding-Doubling method is directly applicable. The calculated luminance for a simple uniform extraction pattern with the Adding-Doubling method matches the luminance generated by a commercial raytracer very well. Although successful, no clear computational advantage over ray tracers is realised. However, the dynamics of light propagation in a light guide as used the Adding-Doubling method, also allow to enhance the efficiency of brute-force ray-tracing algorithms. The performance of this enhanced ray-tracing approach for the simulation of backlights is also evaluated against a typical brute-force ray-tracing approach.

  4. Approaching a more Complete Picture of Rockfall Activity: Seismic and LiDAR Detection, Loaction and Volume Estimates

    Science.gov (United States)

    Dietze, Michael; Mohadjer, Solmaz; Turowski, Jens; Ehlers, Todd; Hovius, Niels

    2016-04-01

    Rockfall activity in steep alpine landscapes is often difficult to survey due to its infrequent nature. Classic approaches are limited by temporal and spatial resolution. In contrast, seismic monitoring provides access to catchment-wide analysis of activity patterns in rockfall-dominated environments. The deglaciated U-shaped Lauterbrunnen Valley in the Bernese Oberland, Switzerland, is a perfect example of such landscapes. It was instrumented with up to six broadband seismometers and repeatedly surveyed by terrestrial LiDAR to provide independent validation data. During August-October 2014 and April-June 2015 more than 23 (LiDAR) to hundred (seismic) events were detected. Their volumes range from conditions that control such processes in a comprehensive way. Taken together, the combined LiDAR and seismic monitoring approach provides high fidelity spatial and temporal resolution of individual events.

  5. A finite volume approach for the simulation of nonlinear dissipative acoustic wave propagation

    CERN Document Server

    Velasco-Segura, Roberto

    2013-01-01

    A form of the conservation equations for fluid dynamics is presented, deduced using slightly less restrictive hypothesis than those necessary to obtain the well known Westervelt equation. This formulation accounts for full wave diffraction, nonlinearity, and thermoviscous dissipative effects. A CLAWPACK based, 2D finite volume method using the Roe linearization was implemented to obtain numerically the solution of the proposed equations. In order to validate the code, two different tests have been performed: one against a special Taylor shock-like analytic solution, the other against published results on a HIFU system, both with satisfactory results. The code is based on CLAWPACK and is written for parallel execution on a GPU, thus improving performance by a factor of over 60 when compared to the standard CLAWPACK code.

  6. Talking and Testing: Discourse Approaches to the Assessment of Oral Proficiency. Studies in Bilingualism, Volume 14.

    Science.gov (United States)

    Young, Richard, Ed.; He, Agnes Weiyun, Ed.

    Papers on second language oral proficiency testing include: "Language Proficiency Interviews: A Discourse Approach" (Agnes Weiyun He, Richard Young); "Re-Analyzing the OPI: How Much Does It Look Like Natural Conversation?" (Marysia Johnson, Andrea Tyler); "Evaluating Learner Interactional Skills: Conversation at the Micro Level" (Heidi…

  7. Complementary and Alternative Medicine Approaches for Pediatric Pain: A Review of the State-of-the-science

    Directory of Open Access Journals (Sweden)

    Jennie C. I. Tsao

    2005-01-01

    Full Text Available In recent years, the use of complementary and alternative medicine (CAM in pediatric populations has increased considerably, especially for chronic conditions such as cancer, rheumatoid arthritis and cystic fibrosis in which pain may be a significant problem. Despite the growing popularity of CAM approaches for pediatric pain, questions regarding the efficacy of these interventions remain. This review critically evaluates the existing empirical evidence for the efficacy of CAM interventions for pain symptoms in children. CAM modalities that possess a published literature, including controlled trials and/or multiple baseline studies, that focused on either chronic or acute, procedural pain were included in this review. The efficacy of the CAM interventions was evaluated according to the framework developed by the American Psychological Association (APA Division 12 Task Force on Promotion and Dissemination of Psychological Procedures. According to these criteria, only one CAM approach reviewed herein (self-hypnosis/guided imagery/relaxation for recurrent pediatric headache qualified as an empirically supported therapy (EST, although many may be considered possibly efficacious or promising treatments for pediatric pain. Several methodological limitations of the existing literature on CAM interventions for pain problems in children are highlighted and future avenues for research are outlined.

  8. MuSiC: a Multibunch and multiparticle Simulation Code with an alternative approach to wakefield effects

    CERN Document Server

    Migliorati, M

    2015-01-01

    The simulation of beam dynamics in presence of collective effects requires a strong computational effort to take into account, in a self consistent way, the wakefield acting on a given charge and produced by all the others. Generally this is done by means of a convolution integral or sum. Moreover, if the electromagnetic fields consist of resonant modes with high quality factors, responsible, for example, of coupled bunch instabilities, a charge is also affected by itself in previous turns, and a very long record of wakefield must be properly taken into account. In this paper we present a new simulation code for the longitudinal beam dynamics in a circular accelerator, which exploits an alternative approach to the currently used convolution sum, reducing the computing time and avoiding the issues related to the length of wakefield for coupled bunch instabilities. With this approach it is possible to simulate, without the need of a large computing power, simultaneously, the single and multi-bunch beam dynamics...

  9. Autologous Fat Grafting as a Novel Approach to Parastomal Soft-tissue Volume Deficiencies

    OpenAIRE

    Robert C. Wu, MD; Ian Maxwell, MD; Ilun Yang, MD, FRCSC; Mario B. Jarmuske, MD, FRCSC; Robin P. Boushey, MD, PhD, FRCSC

    2014-01-01

    Summary: The aim of this study is to describe a novel approach to revise maladaptive soft-tissue contour around an ileostomy. A patient with permanent ileostomy suffered from significant defects in soft-tissue contour due to scarring and wound contraction. He underwent autologous fat grafting to achieve sealing of his stoma appliance and improve cosmesis. Due to numerous surgeries, the stoma appliance would not seal and required daily appliance changes. The patient received autologous fat gra...

  10. Alternative approaches in IVF

    NARCIS (Netherlands)

    B.C.J.M. Fauser (Bart); P. Bouchard; H.J. Coelingh Bennink; J.A. Collins (John); P. Devroey; J.L.H. Evers (Johannes); A. van Steirteghem

    2002-01-01

    textabstractVarious new developments in clinical and basic science which may impact on IVF in the near or distant future will be discussed in this review. These key areas include the regulation of early follicle development and the extended in-vitro culture of oocytes and embryos.

  11. Narrow band SWIR hyperspectral imaging: a new approach based on volume Bragg grating

    Science.gov (United States)

    Verhaegen, M.; Lessard, S.; Blais-Ouellette, S.

    2012-06-01

    Volume Bragg grating technology has enabled the development of a new type of staring hyperspectral camera. Based on Bragg Tunable filters, these hyperspectral cameras have both high spectral and spatial resolution, and significantly higher sensitivity than competing technologies like push broom spectrometer, liquid crystal tunable filters, or acousto-optic tunable filters. They are minimally sensitive to polarization and their spectral isolation can reach 106. Here we thus present an innovative tool to collect SWIR hyperspectral data with high spectral and spatial resolution. This new instrument is based on a 3nm bandwidth Bragg Tunable Filter, continuously tunable from 1.0um and 2.5um. Because high spectral resolution also means less light per channel, a low noise custom HgCdTe (MCT) camera was also developed to meet the requirement of the filter. The high speed capability of more than 300 fps and the low operating temperature of 200K (deep cooled option to 77K) allow full frame 500 spectral channel datacube acquisitions in minimal time. Basic principle of this imaging filter will be reviewed as well as the custom MCT camera performances. High resolution hyperspectral measurements will be demonstrated between 1.0um and 2.5um on different objects.

  12. Evaluation, testing and application of participatory approaches in the Czech Republic Consensus panel - Spent nuclear fuel management alternatives. Deliverable 11

    International Nuclear Information System (INIS)

    An important part of the ARGONA project is the testing and application of novel participation and dialogue approaches. The ways in this is being done include a series of events involving different stakeholders such as a focused science shop, a consensus panel and an interaction panel. In the framework of these activities in the Czech Republic the consensus panel was held on June 12, 2008 in Rez and addressed the theme: 'Spent nuclear fuel management alternatives'. The main goals of this consensus panel were: 1. Identification of the main criteria relevant to the assessment of the existing alternatives and determination their importance (weight) from the perspective of all stakeholders; 2. Achieving at least a partial consensus on selecting the most suitable alternative (management of radioactive waste and spent nuclear fuel). A broader audience was selected with a suitable mixture of specialists and interested technical and non-technical peers including representatives from NRI, universities, Ministry of Industry and Trade, Ministry of the Environment, State Office for Nuclear Safety and Radioactive Waste Repository Authority, representatives of municipalities and NGOs, and waste producers such as CEZ plc etc. In opinion of all participants, there was a 'safe space' for debate ensured and everyone had the same opportunity to express his opinion. All participants also agreed that the whole course of seminar was transparent and correct. From this perspective, the chosen format of dialogue seems appropriate to ensure the exchange of new information and mutual discussion among the interested parties on the contentious issues in the NWM and nuclear energy in general. It was also found, however, that at present the social and political problems are the most important and the most urgent problems in the field of the nuclear waste management in the Czech Republic. It is very important not only to ensure a safe space for meaningful communication, but also: - To increase the

  13. Signal transduction profile of chemical sensitisers in dendritic cells: an endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

    OpenAIRE

    Neves, BM; Gonçalo, Margarida; Figueiredo, A.; Duarte, CB; Lopes, MC; Cruz, MT

    2011-01-01

    The development of non-animal testing methods for the assessment of skin sensitisation potential is an urgent challenge within the framework of existing and forthcoming legislation. Efforts have been made to replace current animal tests, but so far no alternative methods have been developed. It is widely recognised that alternatives to animal testing cannot be accomplished with a single approach, but rather will require the integration of results obtained from different in vitro and in silico...

  14. A novel convolution-based approach to address ionization chamber volume averaging effect in model-based treatment planning systems

    Science.gov (United States)

    Barraclough, Brendan; Li, Jonathan G.; Lebron, Sharon; Fan, Qiyong; Liu, Chihray; Yan, Guanghua

    2015-08-01

    The ionization chamber volume averaging effect is a well-known issue without an elegant solution. The purpose of this study is to propose a novel convolution-based approach to address the volume averaging effect in model-based treatment planning systems (TPSs). Ionization chamber-measured beam profiles can be regarded as the convolution between the detector response function and the implicit real profiles. Existing approaches address the issue by trying to remove the volume averaging effect from the measurement. In contrast, our proposed method imports the measured profiles directly into the TPS and addresses the problem by reoptimizing pertinent parameters of the TPS beam model. In the iterative beam modeling process, the TPS-calculated beam profiles are convolved with the same detector response function. Beam model parameters responsible for the penumbra are optimized to drive the convolved profiles to match the measured profiles. Since the convolved and the measured profiles are subject to identical volume averaging effect, the calculated profiles match the real profiles when the optimization converges. The method was applied to reoptimize a CC13 beam model commissioned with profiles measured with a standard ionization chamber (Scanditronix Wellhofer, Bartlett, TN). The reoptimized beam model was validated by comparing the TPS-calculated profiles with diode-measured profiles. Its performance in intensity-modulated radiation therapy (IMRT) quality assurance (QA) for ten head-and-neck patients was compared with the CC13 beam model and a clinical beam model (manually optimized, clinically proven) using standard Gamma comparisons. The beam profiles calculated with the reoptimized beam model showed excellent agreement with diode measurement at all measured geometries. Performance of the reoptimized beam model was comparable with that of the clinical beam model in IMRT QA. The average passing rates using the reoptimized beam model increased substantially from 92.1% to

  15. Pyrometry in the Multianvil Press: New approach for temperature measurement in large volume press experiments

    Science.gov (United States)

    Sanehira, T.; Wang, Y.; Prakapenka, V.; Rivers, M. L.

    2008-12-01

    Temperature measurement in large volume press experiments has been based on thermocouple emf, which has well known problems: unknown pressure dependence of emf [e.g., 1], chemical reaction between thermocouple and other materials, deformation related texture development in the thermocouple wires [2], and so on. Thus, different techniques to measure temperatures in large volume press experiments other than thermocouples are required to measure accurate temperatures under high pressures. Here we report a new development using pyrometry in the multianvil press, where temperatures are derived on the basis of spectral radiometry. Several high pressure runs were conducted using the 1000 ton press with a DIA module installed at 13 ID-D GSECARS beamline at Advanced Photon Source (APS) [3]. The cubic pressure medium, 14 mm edge length, was made of soft-fired pyrophyllite with a graphite furnace. A moissanite (SiC) single crystal was built inside the pressure medium as a window for the thermal emission signal to go through. An MgO disk with 1.0 mm thickness was inserted in a gap between the top of the SiC crystal and thermocouple hot junction. The bottom of the window crystal was in direct contact with the tip of the anvil, which had a 1.5 mm diameter hole drilled all the way through the anvil axis. An optical fiber was inserted in this hole and the open end of fiber was in contact with the SiC crystal. Thermal spectral radiance from the inner cell assembly was obtained via the fiber and recorded by an Ocean Optics HP2000 spectrometer. The system response of spectrometer was calibrated by a tungsten ribbon ramp (OL550S, Optronic Laboratories, Inc.) with standard of spectral radiance. The cell assembly was compressed up to target value of 15 tons and then temperature was increased up to 1573 K. Radiation spectra were mainly obtained above 873 K and typical integration time was 1 ms or 10 ms. Data collection was done in the process of increase and decrease of temperature. In

  16. An Approach to the Use of Depth Cameras for Weed Volume Estimation.

    Science.gov (United States)

    Andújar, Dionisio; Dorado, José; Fernández-Quintanilla, César; Ribeiro, Angela

    2016-01-01

    The use of depth cameras in precision agriculture is increasing day by day. This type of sensor has been used for the plant structure characterization of several crops. However, the discrimination of small plants, such as weeds, is still a challenge within agricultural fields. Improvements in the new Microsoft Kinect v2 sensor can capture the details of plants. The use of a dual methodology using height selection and RGB (Red, Green, Blue) segmentation can separate crops, weeds, and soil. This paper explores the possibilities of this sensor by using Kinect Fusion algorithms to reconstruct 3D point clouds of weed-infested maize crops under real field conditions. The processed models showed good consistency among the 3D depth images and soil measurements obtained from the actual structural parameters. Maize plants were identified in the samples by height selection of the connected faces and showed a correlation of 0.77 with maize biomass. The lower height of the weeds made RGB recognition necessary to separate them from the soil microrelief of the samples, achieving a good correlation of 0.83 with weed biomass. In addition, weed density showed good correlation with volumetric measurements. The canonical discriminant analysis showed promising results for classification into monocots and dictos. These results suggest that estimating volume using the Kinect methodology can be a highly accurate method for crop status determination and weed detection. It offers several possibilities for the automation of agricultural processes by the construction of a new system integrating these sensors and the development of algorithms to properly process the information provided by them. PMID:27347972

  17. Structured assessment approach version 1. License submittal document content and format for material control and accounting assessment. Volume II

    Energy Technology Data Exchange (ETDEWEB)

    Parziale, A.A.; Sacks, I.J.

    1979-10-01

    A methodology, the Structured Assessment Approach, has been developed for the assessment of the effectiveness of material control and accounting (MC and A) safeguards systems at nuclear fuel cycle facilities. This methodology has been refined into a computational tool, the SAA Version 1 computational package, that was used first to analyze a hypothetical fuel cycle facility and used more recently to assess operational nuclear plants. The Version 1 analysis package is designed to analyze safeguards systems that prevent the diversion of special nuclear material (SNM) from nuclear fuel cycle facilities and to provide assurance that diversion has not occurred. This report is the second volume, the License Submittal Document Content and Format for Material Control and Accounting Assessment, of a four-volume document. It presents the content and format of the LSD necessary for Material Control and Accounting (MC and A) assessment with the SAA Version 1. The LSD is designed to provide the necessary data input to perform all four stages of analyses associated with the SAA. A full-size but Hypothetical Fuel Cycle Facility (HFCF) is used as an example to illustrate the required input data content and data format and to illustrate the procedure for generating the LSD. Generation of the LSD is the responsibility of the nuclear facility licensee applicant.

  18. Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy.

    Science.gov (United States)

    He, Tiantian; Hatem, Elie; Vernis, Laurence; Huang, Meng-Er

    2014-10-01

    Peroxiredoxins have multiple cellular functions as major antioxidants, signaling regulators and tumor suppressors. Peroxiredoxin 1 (PRX1) is the most abundant among the six isoforms of human peroxiredoxins, catalyzing the reduction of peroxides utilizing thioredoxin 1as an electron donor. PRX1 is frequently over-expressed in various cancer cells, which is thought to be associated with carcinogenesis, metastasis and resistance to radiotherapy or chemotherapy. We investigated how modulations of intracellular redox system, especially PRX1, affect cancer cell sensitivity to reactive oxygen species (ROS)-generating drugs. We observed that stable and transient Prx1 knockdown (Prx1-) significantly enhances HeLa cell sensitivity to β-lapachone (β-lap), a potential anticancer agent, and to other ROS-generating molecules. ROS accumulation played a crucial role in drug-enhanced Prx1- cell death. For β-lap, Prx1- cells sensitization is achieved through combined action of accumulation of ROS and enhancement of mitogen-activated protein kinase pathway activation. The effect of other ROS-inducing drugs on Prx1- cell survival will also be presented and discussed. Taken together, our data provide evidence that PRX1 could be an interesting anticancer target and modulation of intracellular redox states through PRX1 inhibition could be an alternative approach to enhance cancer cell sensitivity to ROS-generating drugs. PMID:26461286

  19. Effect of dense plasmas on exchange-energy shifts in highly charged ions: An alternative approach for arbitrary perturbation potentials

    Energy Technology Data Exchange (ETDEWEB)

    Rosmej, F. [Sorbonne Universites, Pierre et Marie Curie, UMR 7605, case 128, 4 place Jussieu, F-75252 Paris (France); Ecole Polytechnique, Laboratoire pour l' Utilisation des Lasers Intenses LULI, Physique Atomique dans les Plasmas Denses PAPD, F-91228 Palaiseau (France); Bennadji, K. [Sorbonne Universites, Pierre et Marie Curie, UMR 7605, case 128, 4 place Jussieu, F-75252 Paris (France); ExtreMe Matter Institute EMMI, GSI Helmholtz Centre of Heavy Ion Research, Planckstrasse 1, D-64291 Darmstadt (Germany); Lisitsa, V. S. [Russian Research Center Kurchatov, Laboratory of Radiation Theory, Kurchatov Square 1, 123182 Moscow (Russian Federation)

    2011-09-15

    An alternative method of calculation of dense plasma effects on exchange-energy shifts {Delta}E{sub x} of highly charged ions is proposed which results in closed expressions for any plasma or perturbation potential. The method is based on a perturbation theory expansion for the inner atomic potential produced by charged plasma particles employing the Coulomb Green function method. This approach allows us to obtain analytic expressions and scaling laws with respect to the electron temperature T, density n{sub e}, and nuclear charge Z. To demonstrate the power of the present method, two specific models were considered in detail: the ion sphere model (ISM) and the Debye screening model (DSM). We demonstrate that analytical expressions can be obtained even for the finite temperature ISM. Calculations have been carried out for the singlet 1s2p{sup 1} P{sub 1} and triplet 1s2p{sup 3} P{sub 1} configurations of He-like ions with charge Z that can be observed in dense plasmas via the He-like resonance and intercombination lines. Finally we discuss recently available purely numerical calculations and experimental data.

  20. A multiobjective ant colony optimization approach for scheduling environmental flow management alternatives with application to the River Murray, Australia

    Science.gov (United States)

    Szemis, J. M.; Dandy, G. C.; Maier, H. R.

    2013-10-01

    In regulated river systems, such as the River Murray in Australia, the efficient use of water to preserve and restore biota in the river, wetlands, and floodplains is of concern for water managers. Available management options include the timing of river flow releases and operation of wetland flow control structures. However, the optimal scheduling of these environmental flow management alternatives is a difficult task, since there are generally multiple wetlands and floodplains with a range of species, as well as a large number of management options that need to be considered. Consequently, this problem is a multiobjective optimization problem aimed at maximizing ecological benefit while minimizing water allocations within the infrastructure constraints of the system under consideration. This paper presents a multiobjective optimization framework, which is based on a multiobjective ant colony optimization approach, for developing optimal trade-offs between water allocation and ecological benefit. The framework is applied to a reach of the River Murray in South Australia. Two studies are formulated to assess the impact of (i) upstream system flow constraints and (ii) additional regulators on this trade-off. The results indicate that unless the system flow constraints are relaxed, there is limited additional ecological benefit as allocation increases. Furthermore the use of regulators can increase ecological benefits while using less water. The results illustrate the utility of the framework since the impact of flow control infrastructure on the trade-offs between water allocation and ecological benefit can be investigated, thereby providing valuable insight to managers.

  1. Draft Programmatic Environmental Impact Statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 1: Main text

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky; Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. The preferred alternative for the long-term management of depleted UF6 is to use the entire inventory of material

  2. Cat dissection and human cadaver prosection versus sculpting human structures from clay: A comparison of alternate approaches to human anatomy laboratory education

    Science.gov (United States)

    Waters, John R.

    Dissection and vivisection are traditional approaches to biology laboratory education. In the case of human anatomy teaching laboratories, there is a long tradition of using human and animal cadaver specimens in the classroom. In a review of the literature comparing traditional dissection and vivisection lessons to alternative lessons designed to reduce the time spent dissecting or the numbers of animals used, we conclude that it is difficult to come to any conclusion regarding the efficacy of different approaches. An analysis of the literature is confounded because many studies have very low statistical power or other methodological weaknesses, and investigators rely on a wide variety of testing instruments to measure an equally varied number of course objectives. Additional well designed studies are necessary before educators can reach any informed conclusions about the efficacy of traditional versus alternative approaches to laboratory education. In our experiments, we compared a traditional cat dissection based undergraduate human anatomy lesson to an alternative where students sculpted human muscles onto plastic human skeletons. Students in the alternative treatment performed significantly better than their peers in the traditional treatment when answering both lower and higher order human anatomy questions. In a subsequent experiment with a similar design, we concluded that the superior performance of the students in the alternative treatment on anatomy exams was likely due to the similarity between the human anatomy representation studied in lab, and the human anatomy questions asked on the exams. When the anatomy questions were presented in the context of a cat specimen, students in the traditional cat dissection treatment outperformed their peers in the alternative treatment. In a final experiment where student performance on a human anatomy exam was compared between a traditional prosected human cadaver treatment and the alternative clay sculpting

  3. A data-driven approach for modeling post-fire debris-flow volumes and their uncertainty

    Science.gov (United States)

    Friedel, M.J.

    2011-01-01

    This study demonstrates the novel application of genetic programming to evolve nonlinear post-fire debris-flow volume equations from variables associated with a data-driven conceptual model of the western United States. The search space is constrained using a multi-component objective function that simultaneously minimizes root-mean squared and unit errors for the evolution of fittest equations. An optimization technique is then used to estimate the limits of nonlinear prediction uncertainty associated with the debris-flow equations. In contrast to a published multiple linear regression three-variable equation, linking basin area with slopes greater or equal to 30 percent, burn severity characterized as area burned moderate plus high, and total storm rainfall, the data-driven approach discovers many nonlinear and several dimensionally consistent equations that are unbiased and have less prediction uncertainty. Of the nonlinear equations, the best performance (lowest prediction uncertainty) is achieved when using three variables: average basin slope, total burned area, and total storm rainfall. Further reduction in uncertainty is possible for the nonlinear equations when dimensional consistency is not a priority and by subsequently applying a gradient solver to the fittest solutions. The data-driven modeling approach can be applied to nonlinear multivariate problems in all fields of study. ?? 2011.

  4. Cost benefit indicators associated with the integration of alternative energy sources: A systems approach for Carinthia, Austria

    DEFF Research Database (Denmark)

    Wohlgemuth, N.

    1999-01-01

    Studies on how to promote the use of alternative energy sources (AES) typically focus on the relative efficiency and effectiveness of alternative subsidising mechanisms. Positive externalities of an increased AES utilisation are in general not explicitly taken into account. This paper analyses, o...

  5. Alternative approaches to correct interferences in the determination of boron in shrimps by electrothermal atomic absorption spectrometry

    International Nuclear Information System (INIS)

    The aim of this study is to propose alternative techniques and methods in combination with the classical chemical modification to correct the major matrix interferences in the determination of boron in shrimps. The performance of an internal standard (Ge) for the determination of boron by the simultaneous multi-element atomic absorption spectrometry was tested. The use of internal standardization increased the recovery from 85.9% to 101% and allowed a simple correction of errors during sampling preparation and heating process. Furthermore, a new preparation procedure based on the use of citric acid during digestion and dilution steps improved the sensitivity of the method and decreased the limit of detection. Finally, a comparative study between the simultaneous multi-element atomic absorption spectrometry with a longitudinal Zeeman-effect background correction system, equipped with a transversely-heated graphite atomizer and the single element atomic absorption spectrometry with a D2 background correction system, equipped with an end-heated graphite atomizer was undertaken to investigate the different behavior of boron in both techniques. Different chemical modifiers for the determination of boron were tested with both techniques. Ni-citric acid and Ca were the optimal chemical modifiers when simultaneous multi-element atomic absorption spectrometry and single-element atomic absorption spectrometry were used, respectively. By using the single-element atomic absorption spectrometry, the calculated characteristic mass was 220 pg and the calculated limit of detection was 370 μg/kg. On the contrary, with simultaneous multi-element atomic absorption spectrometry, the characteristic mass was 2200 pg and the limit of detection was 5.5 mg/kg. - Highlights: • New approaches were developed to cope with interferences of B determination by ETAAS • Ge was used as internal standard for the determination of B by simultaneous ETAAS • Citric acid was used during digestion

  6. Subcutaneous dissociative conscious sedation (sDCS an alternative method for airway regional blocks: a new approach

    Directory of Open Access Journals (Sweden)

    Javid Mihan J

    2011-10-01

    Full Text Available Abstract Background Predicted difficult airway is a definite indication for awake intubation and spontaneous ventilation. Airway regional blocks which are commonly used to facilitate awake intubation are sometimes impossible or forbidden. On the other hand deep sedation could be life threatening in the case of compromised airway. The aim of this study is evaluating "Subcutaneous Dissociative Conscious Sedation" (sDCS as an alternative method to airway regional blocks for awake intubation. Methods In this prospective, non-randomized study, 30 patients with predicted difficult airway (laryngeal tumors, who were scheduled for direct laryngoscopic biopsy (DLB, underwent "Subcutaneous Dissociative Conscious Sedation" (sDCS exerted by intravenous fentanyl 3-4ug/kg and subcutaneous ketamine 0.6-0.7 mg/kg. The tongue and pharynx were anesthetized with lidocaine spray (4%. 10 minutes after a subcutaneous injection of ketamine direct laryngoscopy was performed. Extra doses of fentanyl 50-100 ug were administered if the patient wasn't cooperative enough for laryngoscopy. Patients were evaluated for hemodynamic stability (heart rate and blood pressure, oxygen saturation (Spo2, patient cooperation (obedient to open the mouth for laryngoscopy and the number of tries for laryngoscopy, patient comfort (remaining moveless, hallucination, nystagmus and salivation (need for aspiration before laryngoscopy. Results Direct laryngoscopy was performed successfully in all patients. One patient needed extra fentanyl and then laryngoscopy was performed successfully on the second try. All patients were cooperative enough during laryngoscopy. Hemodynamic changes more than 20% occurred in just one patient. Oxygen desaturation (spo2 Conclusions Subcutaneous Dissociative Conscious Sedation (sDCS as a new approach to airway is an acceptable and safe method for awake intubation and it can be suggested as a noninvasive substitute of low complication rate for regional airway

  7. Alternative approaches to correct interferences in the determination of boron in shrimps by electrothermal atomic absorption spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Pasias, I.N.; Pappa, Ch.; Katsarou, V.; Thomaidis, N.S., E-mail: ntho@chem.uoa.gr; Piperaki, E.A.

    2014-02-01

    The aim of this study is to propose alternative techniques and methods in combination with the classical chemical modification to correct the major matrix interferences in the determination of boron in shrimps. The performance of an internal standard (Ge) for the determination of boron by the simultaneous multi-element atomic absorption spectrometry was tested. The use of internal standardization increased the recovery from 85.9% to 101% and allowed a simple correction of errors during sampling preparation and heating process. Furthermore, a new preparation procedure based on the use of citric acid during digestion and dilution steps improved the sensitivity of the method and decreased the limit of detection. Finally, a comparative study between the simultaneous multi-element atomic absorption spectrometry with a longitudinal Zeeman-effect background correction system, equipped with a transversely-heated graphite atomizer and the single element atomic absorption spectrometry with a D{sub 2} background correction system, equipped with an end-heated graphite atomizer was undertaken to investigate the different behavior of boron in both techniques. Different chemical modifiers for the determination of boron were tested with both techniques. Ni-citric acid and Ca were the optimal chemical modifiers when simultaneous multi-element atomic absorption spectrometry and single-element atomic absorption spectrometry were used, respectively. By using the single-element atomic absorption spectrometry, the calculated characteristic mass was 220 pg and the calculated limit of detection was 370 μg/kg. On the contrary, with simultaneous multi-element atomic absorption spectrometry, the characteristic mass was 2200 pg and the limit of detection was 5.5 mg/kg. - Highlights: • New approaches were developed to cope with interferences of B determination by ETAAS • Ge was used as internal standard for the determination of B by simultaneous ETAAS • Citric acid was used during

  8. A forecast of household ownership and use of alternative fuel vehicles: A multiple discrete-continuous choice approach

    International Nuclear Information System (INIS)

    The paper analyzes how adding alternative fuel passenger cars to the market will affect patterns in demand for passenger cars. We use conjoint analysis and a multiple discrete-continuous choice model to estimate consumer preferences regarding alternative fuel vehicles, and based on the estimates we conduct a simulation to analyze changing rates of ownership and use of variously fueled passenger cars under the effect of the introduction of alternative fuel passenger cars. In addition, we estimate changes in overall fuel consumption and the emission of pollutants. The results show that gasoline-fueled cars will still be most consumers' first choice, but alternative fuel passenger cars will nevertheless compete and offer a substitute for the purchase and use of gasoline-fueled or diesel-fueled cars. Finally, results show that adding alternative fuel cars to the market would effectively lower gasoline and diesel fuel consumption and the emission of pollutants. (author)

  9. A forecast of household ownership and use of alternative fuel vehicles: A multiple discrete-continuous choice approach

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Jiwoon [Korea Energy Economics Institute, Naeson 2-dong, Uiwang-si, Gyeonggi-do, 437-713 (Korea); Jeong, Gicheol [Technology Management, Economics and Policy Program, 37-402, College of Engineering, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul, 151-744 (Korea); Kim, Yeonbae [Technology Management, Economics and Policy Program, 37-318, College of Engineering, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, South Seoul, 151-744 (Korea)

    2008-09-15

    The paper analyzes how adding alternative fuel passenger cars to the market will affect patterns in demand for passenger cars. We use conjoint analysis and a multiple discrete-continuous choice model to estimate consumer preferences regarding alternative fuel vehicles, and based on the estimates we conduct a simulation to analyze changing rates of ownership and use of variously fueled passenger cars under the effect of the introduction of alternative fuel passenger cars. In addition, we estimate changes in overall fuel consumption and the emission of pollutants. The results show that gasoline-fueled cars will still be most consumers' first choice, but alternative fuel passenger cars will nevertheless compete and offer a substitute for the purchase and use of gasoline-fueled or diesel-fueled cars. Finally, results show that adding alternative fuel cars to the market would effectively lower gasoline and diesel fuel consumption and the emission of pollutants. (author)

  10. The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism

    Directory of Open Access Journals (Sweden)

    Hoskins Clare

    2012-04-01

    Full Text Available Abstract Background Iron oxide magnetic nanoparticles (MNP's have an increasing number of biomedical applications. As such in vitro characterisation is essential to ensure the bio-safety of these particles. Little is known on the cellular interaction or effect on membrane integrity upon exposure to these MNPs. Here we synthesised Fe3O4 and surface coated with poly(ethylenimine (PEI and poly(ethylene glycol (PEG to achieve particles of varying surface positive charges and used them as model MNP's to evaluate the relative utility and limitations of cellular assays commonly applied for nanotoxicity assessment. An alternative approach, atomic force microscopy (AFM, was explored for the analysis of membrane structure and cell morphology upon interacting with the MNPs. The particles were tested in vitro on human SH-SY5Y, MCF-7 and U937 cell lines for reactive oxygen species (ROS production and lipid peroxidation (LPO, LDH leakage and their overall cytotoxic effect. These results were compared with AFM topography imaging carried out on fixed cell lines. Results Successful particle synthesis and coating were characterised using FTIR, PCS, TEM and ICP. The particle size from TEM was 30 nm (−16.9 mV which increased to 40 nm (+55.6 mV upon coating with PEI and subsequently 50 nm (+31.2 mV with PEG coating. Both particles showed excellent stability not only at neutral pH but also in acidic environment of pH 4.6 in the presence of sodium citrate. The higher surface charge MNP-PEI resulted in increased cytotoxic effect and ROS production on all cell lines compared with the MNP-PEI-PEG. In general the effect on the cell membrane integrity was observed only in SH-SY5Y and MCF-7 cells by MNP-PEI determined by LDH leakage and LPO production. AFM topography images showed consistently that both the highly charged MNP-PEI and the less charged MNP-PEI-PEG caused cell morphology changes possibly due to membrane disruption and cytoskeleton remodelling. Conclusions

  11. Validation of analytical methods in GMP: the disposable Fast Read 102® device, an alternative practical approach for cell counting

    Directory of Open Access Journals (Sweden)

    Gunetti Monica

    2012-05-01

    Full Text Available Abstract Background The quality and safety of advanced therapy products must be maintained throughout their production and quality control cycle to ensure their final use in patients. We validated the cell count method according to the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use and European Pharmacopoeia, considering the tests’ accuracy, precision, repeatability, linearity and range. Methods As the cell count is a potency test, we checked accuracy, precision, and linearity, according to ICH Q2. Briefly our experimental approach was first to evaluate the accuracy of Fast Read 102® compared to the Bürker chamber. Once the accuracy of the alternative method was demonstrated, we checked the precision and linearity test only using Fast Read 102®. The data were statistically analyzed by average, standard deviation and coefficient of variation percentages inter and intra operator. Results All the tests performed met the established acceptance criteria of a coefficient of variation of less than ten percent. For the cell count, the precision reached by each operator had a coefficient of variation of less than ten percent (total cells and under five percent (viable cells. The best range of dilution, to obtain a slope line value very similar to 1, was between 1:8 and 1:128. Conclusions Our data demonstrated that the Fast Read 102® count method is accurate, precise and ensures the linearity of the results obtained in a range of cell dilution. Under our standard method procedures, this assay may thus be considered a good quality control method for the cell count as a batch release quality control test. Moreover, the Fast Read 102® chamber is a plastic, disposable device that allows a number of samples to be counted in the same chamber. Last but not least, it overcomes the problem of chamber washing after use and so allows a cell count in a clean environment such as that in a

  12. Reappraisal of the geothermal potential at Colli Albani volcano (Italy): a new approach to the volume method

    Science.gov (United States)

    Giordano, G.; De Benedetti, A. A.; Ramazzotti, P.; Bonamico, A.; Mattei, M.

    2012-04-01

    High enthalpy geothermal reservoirs are usually associated with fractured rocks. Secondary permeability is however difficult to be predicted thus making it difficult to locate the most productive volumes of the reservoirs. The calculation of the energetic potential in geothermal areas suffers of the large uncertainties associated with secondary permeability issues, facing the task of the interplay between stratification and fracturing on the anisotropic distribution of secondary permeability. The object of this work is the research and informatization of available data for the Colli Albani (Latium, Central Italy) geothermal system, in order to propose a qualitative approach and quantitative identification and description of geothermal systems, applied to the Colli Albani area as a case history. The identification of the rock volumes most promising in terms of industrial exploitation needs the definition of an evaluation matrix. The considered data can be placed in a three dimensional matrix with A axis that accounts for the modeling of the depth of the top of the reservoirs based on geophysical and direct data, and a B axis that accounts for the thermal modeling of the crust (i.e. T with depth) based on measured thermal gradients. Both A and B data are strongly influenced by the geological model therefore, as for the case of Colli Albani, there is certainly a lot of scope into revising existing geological reconstructions of the reservoirs in Central Italy and accordingly reconsidering the interpolation and modeling of both thermal and geophysical data. For the scope of this work, we have taken into account the maps descriptive the thermal structure and the deep distribution of the top of the geothermal reservoirs produced by ENEL and AGIP between the 1970s and 1990s for Cental Italy, and we have detailed the internal structure of the substrate, considering more recent direct and indirect data on the nature of the substratum. Finally, we discuss the implementation

  13. A numerical-statistical approach to determining the representative elementary volume (REV of cement paste for measuring diffusivity

    Directory of Open Access Journals (Sweden)

    Zhang, M. Z.

    2010-12-01

    Full Text Available Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV, in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First, several series of 3D cement paste microstructures were generated with HYMOSTRUC3D, a cement hydration and microstructure model, for different volumes of cement paste and w/c ratios ranging from 0.30 to 0.60. Second, the finite element method was used to simulate the diffusion of tritiated water through these microstructures. Effective cement paste diffusivity values for different REVs were obtained by applying Fick’s law. Finally, statistical analysis was used to find the fluctuation in effective diffusivity with cement paste volume, from which the REV was then determined. The conclusion drawn was that the REV for measuring diffusivity in cement paste is 100x100x100 μm3.

    La difusividad del hormigón depende de su microestructura a numerosas escalas, desde nanómetros hasta milímetros, por lo que se precisa de técnicas multiescala para representar este parámetro. Junto con el principio de homogeneización, uno de los métodos multiescala más habituales es el volumen elemental representativo (VER. El objeto de este estudio era establecer un procedimiento que permitiera determinar el VER necesario para calcular la difusividad de la pasta de cemento, basándose en un método numéricoestadístico que consta de tres etapas. Primero, se crearon varias series de microestructuras de pasta de cemento en 3D con HYMOSTRUC3D, un programa que permite crear un modelo de la hidratación y microestructura del cemento. Luego se empleó el método de

  14. Final programmatic environmental impact statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 1: Main text

    International Nuclear Information System (INIS)

    This PEIS assesses the potential impacts of alternative management strategies for depleted uranium hexafluoride (UF6) currently stored at three DOE sites: Paducah site near Paducah, Kentucky, Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF6, long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. DOE's preferred alternative is to begin conversion of the depleted UF6 inventory as soon as possible, either to uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible

  15. Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Mejia, J.; Galvis-Alonso, O.Y. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Faculdade de Medicina. Dept. de Biologia Molecular], e-mail: mejia_famerp@yahoo.com.br; Braga, J. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Div. de Astrofisica; Correa, R. [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Div. de Ciencia Espacial e Atmosferica; Leite, J.P. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Neurologia, Psiquiatria e Psicologia Medica; Simoes, M.V. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Clinica Medica

    2009-08-15

    Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multi pinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target's radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals. (author)

  16. Alternative approaches of SiC and related wide bandgap materials in light emitting and solar cell applications

    International Nuclear Information System (INIS)

    Materials for optoelectronics give a fascinating variety of issues to consider. Increasingly important are white light emitting diode (LED) and solar cell materials. Profound energy savings can be done by addressing new materials. White light emitting diodes are becoming common in our lighting scene. There is a great energy saving in the transition from the light bulb to white light emitting diodes via a transition of fluorescent light tubes. However, the white LEDs still suffer from a variety of challenges in order to be in our daily use. Therefore there is a great interest in alternative lighting solutions that could be part of our daily life. All materials create challenges in fabrication. Defects reduce the efficiency of optical transitions involved in the light emitting diode materials. The donor-acceptor co-doped SiC is a potential light converter for a novel monolithic all-semiconductor white LED. In spite of considerable research, the internal quantum efficiency is far less than theoretically predicted and is likely a fascinating scientific field for studying materials growth, defects and optical transitions. Still, efficient Si-based light source represents an ongoing research field in photonics that requires high efficiency at room temperature, wavelength tuning in a wide wavelength range, and easy integration in silicon photonic devices. In some of these devices, rare earth doped materials is considered as a potential way to provide luminescence spanning in a wide wavelength range. Divalent and trivalent oxidation states of Eu provide emitting centers in the visible region. In consideration, the use of Eu in photonics requires Eu doped thin films that are compatible with CMOS technology but for example faces material science issues like a low Eu solid solubility in silica. Therefore approaches aim to obtain efficient light emission from silicon oxycarbide which has a luminescence in the visible range and can be a host material for rare earth ions. The

  17. Study of Manpower Requirements by Occupation for Alternative Technologies in the Energy-Related Industries, 1970-1990. Volumes I, IIA, and III.

    Science.gov (United States)

    Gutmanis, Ivars; And Others

    The report presents the methodology used by the National Planning Association (NPA), under contract to the Federal Energy Administration (FEA), to estimate direct labor usage coefficients in some sixty different occupational categories involved in construction, operation, and maintenance of energy facilities. Volume 1 presents direct labor usage…

  18. Lifeline electric rates and alternative approaches to the problems of low-income ratepayers: cross-program summary

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    The purpose of this study was to aid the US Department of Energy in developing materials to assist state regulatory authorities and nonregulated utilities in determining whether or not to implement lifeline rates. In accordance with this objective, case studies of ten implemented and ten rejected lifeline-rate programs were conducted. The initiation and implementation of these programs are described in detail and their actual or anticipated impact on conservation, efficiency, and equity are assessed. The findings of the study are reported in three volumes. The first volume provides general overview and cross-program comparisons of the social and economic context of lifeline, governmental process, and impact assessment. Volume 2 describes the case studies of the 10 implemented programs and Volume 3 describes the 10 non-implemented lifeline proposals. The programs were selected so that in each of these groups at least one program would have the following eligibility requirements: all residential users; elderly low-income residential users; and elderly residential users. (MCW)

  19. An Alternative Approach to the Extraction of Structure Functions in Deep Inelastic e-p Scattering at 5 to 20 GeV

    Institute of Scientific and Technical Information of China (English)

    N. Ghahramany; M. Nouri

    2003-01-01

    Two structure functions W1(x,Q2) and W2(x,Q2) are determined by using the cross sections measured in the deep inelastic electron-proton scattering experiments at Stanford Linac in the energy range of 5 to 20 GeV. In this paper an alternative mathematical approach have been used in such determination, resulting in a larger number of points in the graphs of the structure functions.

  20. Phase diagram of mixtures of hard colloidal spheres and discs: A free-volume scaled-particle approach

    NARCIS (Netherlands)

    Lekkerkerker, H.N.W.; Oversteegen, S.M.

    2004-01-01

    Phase diagrams of mixtures of colloidal hard spheres with hard discs are calculated by means of the free-volume theory. The free-volume fraction available to the discs is determined from scaled-particle theory. The calculations show that depletion induced phase separation should occur at low disc co

  1. Space shuttle/food system. Volume 2, Appendix C: Food cooling techniques analysis. Appendix D: Package and stowage: Alternate concepts analysis

    Science.gov (United States)

    1974-01-01

    The relative penalties associated with various techniques for providing an onboard cold environment for storage of perishable food items, and for the development of packaging and vehicle stowage parameters were investigated in terms of the overall food system design analysis of space shuttle. The degrees of capability for maintaining both a 40 F to 45 F refrigerated temperature and a 0 F and 20 F frozen environment were assessed for the following cooling techniques: (1) phase change (heat sink) concept; (2) thermoelectric concept; (3) vapor cycle concept; and (4) expendable ammonia concept. The parameters considered in the analysis were weight, volume, and spacecraft power restrictions. Data were also produced for packaging and vehicle stowage parameters which are compatible with vehicle weight and volume specifications. Certain assumptions were made for food packaging sizes based on previously generated space shuttle menus. The results of the study are shown, along with the range of meal choices considered.

  2. A Behavioral Perspective of Childhood Trauma and Attachment Issues: Toward Alternative Treatment Approaches for Children with a History of Abuse

    Science.gov (United States)

    Prather, Walter; Golden, Jeannie A.

    2009-01-01

    Attachment theory provides a useful conceptual framework for understanding trauma and the treatment of children who have been abused. This article examines childhood trauma and attachment issues from the perspective of behavior analysis, and provides a theoretical basis for two alternative treatment models for previously abused children and their…

  3. Using Alternative Approaches to Prioritize Testing for the Universe of Chemicals with Potential for Human Exposure (WC9)

    Science.gov (United States)

    One use of alternative methods is to target animal use at only those chemicals and tests that are absolutely necessary. We discuss prioritization of testing based on high-throughput screening assays (HTS), QSAR modeling, high-throughput toxicokinetics (HTTK), and exposure modelin...

  4. Regional Seminar on Alternative Approaches to School Education at Primary Level (Manila, 6-14 December, 1976). Final Report.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and Oceania.

    This paper represents the final report of a regional seminar (Asian countries) on educational alternatives held under the auspices of UNESCO in December 1976. The seminar focused on educational services for children from 5 to 14 years of age and emphasized the needs of children in poverty areas. Limitations and inequities in the current…

  5. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    International Nuclear Information System (INIS)

    Volume III explores resources and fuel cycle facilities. Chapters are devoted to: estimates of US uranium resources and supply; comparison of US uranium demands with US production capability forecasts; estimates of foreign uranium resources and supply; comparison of foreign uranium demands with foreign production capability forecasts; and world supply and demand for other resources and fuel cycle services. An appendix gives uranium, fissile material, and separative work requirements for selected reactors and fuel cycles

  6. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Volume III explores resources and fuel cycle facilities. Chapters are devoted to: estimates of US uranium resources and supply; comparison of US uranium demands with US production capability forecasts; estimates of foreign uranium resources and supply; comparison of foreign uranium demands with foreign production capability forecasts; and world supply and demand for other resources and fuel cycle services. An appendix gives uranium, fissile material, and separative work requirements for selected reactors and fuel cycles.

  7. Alternative method for volumetric core removal in hardsetting soils Método alternativo para a retirada de anéis volumétricos em solos coesos

    OpenAIRE

    Herdjania Veras de Lima; Álvaro Pires da Silva; Sílvia Imhoff; Afrânio Ferreira Neves Junior

    2005-01-01

    Due to the narrow window of ideal moisture conditions required for collecting undisturbed soil samples from hardsetting horizons in the field, this study compared the efficiency of an alternative method of soil core removal in the laboratory with that of the traditional field method by using measurements of soil bulk density data (Db). In a first sampling, cylinders were removed with a soil sampler in the field. In a second sampling, large soil blocks were removed with Kubiena-type zinc (bras...

  8. Numerical modelling in building thermo-aeraulics: from CFD modelling to an hybrid finite volume / zonal approach; Modelisation numerique de la thermoaeraulique du batiment: des modeles CFD a une approche hybride volumes finis / zonale

    Energy Technology Data Exchange (ETDEWEB)

    Bellivier, A.

    2004-05-15

    For 3D modelling of thermo-aeraulics in building using field codes, it is necessary to reduce the computing time in order to model increasingly larger volumes. The solution suggested in this study is to couple two modelling: a zonal approach and a CFD approach. The first part of the work that was carried out is the setting of a simplified CFD modelling. We propose rules for use of coarse grids, a constant effective viscosity law and adapted coefficients for heat exchange in the framework of building thermo-aeraulics. The second part of this work concerns the creation of fluid Macro-Elements and their coupling with a calculation of CFD finite volume type. Depending on the boundary conditions of the problem, a local description of the driving flow is proposed via the installation and use of semi-empirical evolution laws. The Macro-Elements is then inserted in CFD computation: the values of velocity calculated by the evolution laws are imposed on the CFD cells corresponding to the Macro-Element. We use these two approaches on five cases representative of thermo-aeraulics in buildings. The results are compared with experimental data and with traditional RANS simulations. We highlight the significant gain of time that our approach allows while preserving a good quality of numerical results. (author)

  9. A virtual repository approach to clinical and utilization studies: application in mammography as alternative to a national database.

    OpenAIRE

    Ohno-Machado, L.; Boxwala, A. A.; Ehresman, J.; Smith, D N; Greenes, R. A.

    1997-01-01

    A national mammography database was proposed, based on a centralized architecture for collecting, monitoring, and auditing mammography data. We have developed an alternative architecture relying on Internet-based distributed queries to heterogeneous databases. This architecture creates a "virtual repository", or a federated database which is constructed dynamically, for each query and makes use of data available in legacy systems. It allows the construction of custom-tailored databases at ind...

  10. An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.

    OpenAIRE

    Xiao-Tong Song; Kevin Evel-Kabler; Lisa Rollins; Melissa Aldrich; Feng Gao; Xue F Huang; Si-Yi Chen

    2006-01-01

    BACKGROUND: Current efforts to develop HIV vaccines that seek to stimulate immune responses have been disappointing, underscoring the inability of natural immune responses to control HIV-1 infection. Here we tested an alternative strategy to induce anti-HIV immune responses by inhibiting a host's natural immune inhibitor. METHODS AND FINDINGS: We used small interfering RNA (siRNA) to inhibit suppressor of cytokine signaling (SOCS) 1, a key negative regulator of the JAK/STAT pathway, and inves...

  11. Subsistence farmer preferences for alternative incentive policies to encourage the adoption of conservation agriculture in Malawi: A choice elicitation approach

    OpenAIRE

    Marenya, Paswel Phiri; Smith, Vincent H.; Nkonya, Ephraim M.

    2012-01-01

    Land degradation in most sub Saharan Africa is a widely recognized problem and is due in large part to poor land management practices. To address this problem, several policy-based incentives to increase the adoption of better land management practices have been proposed, including fertilizer subsidies, cash payments and, more recently, subsidized or commercially offered weather index-based insurance contracts. However, little is known about farmers’ preferences among these policy alternative...

  12. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle description

    International Nuclear Information System (INIS)

    The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates

  13. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle description

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates.

  14. Quantitative Imaging Assessment of an Alternative Approach to Surgical Mitral Valve Leaflet Resection: An Acute Porcine Study.

    Science.gov (United States)

    Boronyak, Steven M; Fredi, Joseph L; Young, Michael N; Dumont, Douglas M; Williams, Phillip E; Byram, Brett C; Merryman, W David

    2016-07-01

    This study reports the initial in vivo use of a combined radiofrequency ablation and cryo-anchoring (RFC) catheter as an alternative to surgical mitral valve (MV) leaflet resection. Radiofrequency ablation thermally shrinks enlarged collagenous tissues, providing an alternative to leaflet resection, and cryo-anchoring provides reversible attachment of a catheter to freely mobile MV leaflets. Excised porcine MVs (n = 9) were tested in a left heart flow simulator to establish treatment efficacy criteria. Resected leaflet area was quantified by tracking markers on the leaflet surface, and leaflet length reductions were directly measured on echocardiography. Leaflet area decreased by 38 ± 2.7%, and leaflet length decreased by 9.2 ± 1.8% following RFC catheter treatment. The RFC catheter was then tested acutely in healthy pigs (n = 5) under epicardial echocardiographic guidance, open-chest without cardiopulmonary bypass, using mid-ventricular free wall access. Leaflet length was quantified using echocardiography. Quantitative assessment of MV leaflet length revealed that leaflet resection was successful in 4 of 5 pigs, with a leaflet length reduction of 13.3 ± 4.6%. Histological, mechanical, and gross pathological findings also confirmed that RFC catheter treatment was efficacious. The RFC catheter significantly reduces MV leaflet size in an acute animal model, providing a possible percutaneous alternative to surgical leaflet resection. PMID:26508331

  15. Process system evaluation-consolidated letters. Volume 1. Alternatives for the off-gas treatment system for the low-level waste vitrification process

    Energy Technology Data Exchange (ETDEWEB)

    Peurrung, L.M.; Deforest, T.J; Richards, J.R.

    1996-03-01

    This report provides an evaluation of alternatives for treating off-gas from the low-level waste (LLW) melter. The study used expertise obtained from the commercial nonradioactive off-gas treatment industry. It was assumed that contact maintenance is possible, although the subsequent risk to maintenance personnel was qualitatively considered in selecting equipment. Some adaptations to the alternatives described may be required, depending on the extent of contact maintenance that can be achieved. This evaluation identified key issues for the off-gas system design. To provide background information, technology reviews were assembled for various classifications of off-gas treatment equipment, including off-gas cooling, particulate control, acid gas control, mist elimination, NO{sub x} reduction, and SO{sub 2} removal. An order-of-magnitude cost estimate for one of the off-gas systems considered is provided using both the off-gas characteristics associated with the Joule-heated and combustion-fired melters. The key issues identified and a description of the preferred off-gas system options are provided below. Five candidate treatment systems were evaluated. All of the systems are appropriate for the different melting/feed preparations currently being considered. The lowest technical risk is achieved using option 1, which is similar to designs for high-level waste (HLW) vitrification in the Hanford Waste Vitrification Project (HWVP) and the West Valley. Demonstration Project. Option 1 uses a film cooler, submerged bed scrubber (SBS), and high-efficiency mist eliminator (HEME) prior to NO{sub x} reduction and high-efficiency particulate air (HEPA) filtration. However, several advantages were identified for option 2, which uses high-temperature filtration. Based on the evaluation, option 2 was identified as the preferred alternative. The characteristics of this option are described below.

  16. Does the Addition of Inert Gases at Constant Volume and Temperature Affect Chemical Equilibrium?

    Science.gov (United States)

    Paiva, Joao C. M.; Goncalves, Jorge; Fonseca, Susana

    2008-01-01

    In this article we examine three approaches, leading to different conclusions, for answering the question "Does the addition of inert gases at constant volume and temperature modify the state of equilibrium?" In the first approach, the answer is yes as a result of a common students' alternative conception; the second approach, valid only for ideal…

  17. A novel geotechnical/geostatistical approach for exploration and production of natural gas from multiple geologic strata, Phase 1. Volume 2, Geology and engineering

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Reeves, T.K.; Salamy, S.P.; Locke, C.D.; Johnson, H.R.; Brunk, R.; Hawkins, L. [BDM Engineering Services Co., Morgantown, WV (United States)

    1991-05-01

    This research program has been designed to develop and verify a unique geostatistical approach for finding natural gas resources. The project has been conducted by Beckley College, Inc., and BDM Engineering Services Company (BDMESC) under contract to the US Department of Energy (DOE), Morgantown Energy Technology Center (METC). This section, Volume II, contains a detailed discussion of the methodology used and the geological and production information collected and analyzed for this study. A companion document, Volume 1, provides an overview of the program, technique and results of the study. In combination, Volumes I and II cover the completion of the research undertaken under Phase I of this DOE project, which included the identification of five high-potential sites for natural gas production on the Eccles Quadrangle, Raleigh County, West Virginia. Each of these sites was selected for its excellent potential for gas production from both relatively shallow coalbeds and the deeper, conventional reservoir formations.

  18. Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

    International Nuclear Information System (INIS)

    The development of non-animal testing methods for the assessment of skin sensitisation potential is an urgent challenge within the framework of existing and forthcoming legislation. Efforts have been made to replace current animal tests, but so far no alternative methods have been developed. It is widely recognised that alternatives to animal testing cannot be accomplished with a single approach, but rather will require the integration of results obtained from different in vitro and in silico assays. The argument subjacent to the development of in vitro dendritic cell (DC)-based assays is that sensitiser-induced changes in the DC phenotype can be differentiated from those induced by irritants. This assumption is derived from the unique capacity of DC to convert environmental signals encountered at the skin into a receptor expression pattern (MHC class II molecules, co-stimulatory molecules, chemokine receptors) and a soluble mediator release profile that will stimulate T lymphocytes. Since signal transduction cascades precede changes in surface marker expression and cytokine/chemokine secretion, these phenotypic modifications are a consequence of a signal transduction profile that is specifically triggered by sensitisers and not by irritants. A limited number of studies have addressed this subject and the present review attempts to summarise and highlight all of the signalling pathways modulated by skin sensitisers and irritants. Furthermore, we conclude this review by focusing on the most promising strategies suitable for inclusion into a cell-based in vitro alternative approach to hazard identification.

  19. Genefish: an alternate metagenomic approach for capturing targeted bacterial diversity in an engineered recipient E. coli strain

    OpenAIRE

    Lombard, Nathalie; Faugier, Aurélie; Lavire, Céline; Jacquiod, Samuel; Philippot, Laurent; Zhang, Xiaojun; Lazzaroni, Jean-Claude; Simonet, Pascal; Franqueville, Laure

    2009-01-01

    The metagenomic approach, defined as the direct recovery and cloning of bacterial DNA from the environment in domesticated bacterial hosts has been widely used to study bacterial populations and their functional genes in numerous environments. The advantage of this approach over conventional culture based techniques is that it encompasses a wider range of bacteria by bypassing the bias of uncultivability of more than 99% of the bacteria in soil. However, in complex and rich environments such ...

  20. A Hybrid Approach Using ISM For Leveling Agile Criteria And Fuzzy AHP To Determine The Relative Weights Of Evaluation Criteria And Fuzzy TOPSIS To Rank The Alternatives

    Directory of Open Access Journals (Sweden)

    Mahdi Karbasian1

    2012-02-01

    Full Text Available In today’s organizations, performance measurement comes more to the foreground with the advancement in the high technology. Supplier selection is an important issue in supply chain management. In recent years, determining the best supplier in the supply chain has become a key strategic consideration. However, these decisions usually involve several objectives or criteria, and it is often necessary to compromise among possibly conflicting factors. Thus, the multiple criteria decision making (MCDM becomes a useful approach to solve this kind of problem. In order to use the conceptual framework for measuring performance supplier, a methodology that takes into account both quantitative and qualitative factors and the interrelations between them should be utilized. for leveling an integrated approach of analytic hierarchy process AHP and fuzzy TOPSIS method is proposed to obtain final ranking. The interactions among the criteria are also analyzed before arriving at a decision for the selection of supplier from among six alternatives. Linguistic values are used to assess the ratings and weights for criterion. These linguistic ratings can be expressed in triangular fuzzy numbers. Then, a hierarchy multiple criteria decision-making (MCDM model based on fuzzy-sets theory including FAHP and FTOPSIS are applied. There are two approaches for aggregating values including relative importance of evaluation criteria with respect to the overall objective and rating of alternatives with respect to each criterion in fuzzy group TOPSIS: First aggregation and Last aggregation. In first aggregation approach weight of each criterion and rating of alternatives with respect to each criterion gained from decision makers are aggregated at first and TOPSIS method then apply to these aggregate values. In last aggregation approach weight of each criterion and rating of alternatives with respect to each criterion gained from decision makers are used in TOPSIS method

  1. Climate. For a successful change. Volume 1: How to commit one's territory in an adaptation approach. Volume 2: How to implement a territorial project which integrates adaptation. Volume 3: How to understand the complexity of climate change - Scientific issues

    International Nuclear Information System (INIS)

    The first volume presents the climate issue as a world issue as well as a local issue (historic context of adaptation to climate change effects, legal obligation for local communities, indicators of direct and indirect effects of climate change, economic impacts), and presents adaptation as a way of action at a local level (definition of a strategy, articulation between works on greenhouse gas emissions and those on adaptation, actions to be implemented, action follow-up and adjustment). The second volume describes how to communicate and talk about climate change, and more specifically about the above-mentioned issues (reality of climate change, indirect and direct effects, obligations and responsibilities for local communities, economic impacts). It addresses the issue of climate change in the Rhone-Alpes region: adaptation within the regional scheme on climate, air and energy (SRCAE), role of local communities. It presents an action methodology: to inform and organise, to prepare the mobilisation of actors, to prepare the territory vulnerability diagnosis, to define the adaptation strategy, and to implement, follow-up and assess the action. The third volume proposes a set of sheets containing scientific information and data related to climate change: factors of climate variability, current global warming, greenhouse gases and aerosols, physical-chemical principles involved in greenhouse effect, carbon sinks and carbon sources, effects of land assignment and agriculture, combined effects of mankind actions on the atmosphere, climate change and oceans, climate change and cryo-sphere, climate change and biodiversity, extreme meteorological and climate events and their consequences

  2. Design Concept for a Minimal Volume Spacecraft Cabin to Serve as a Mars Ascent Vehicle Cabin and Other Alternative Pressurized Vehicle Cabins

    Science.gov (United States)

    Howard, Robert L., Jr.

    2016-01-01

    The Evolvable Mars Campaign is developing concepts for human missions to the surface of Mars. These missions are round-trip expeditions, thereby requiring crew launch via a Mars Ascent Vehicle (MAV). A study to identify the smallest possible pressurized cabin for this mission has developed a conceptual vehicle referred to as the minimal MAV cabin. The origin of this concept will be discussed as well as its initial concept definition. This will lead to a description of possible configurations to integrate the minimal MAV cabin with ascent vehicle engines and propellant tanks. Limitations of this concept will be discussed, in particular those that argue against the use of the minimal MAV cabin to perform the MAV mission. However, several potential alternative uses for the cabin are identified. Finally, recommended forward work will be discussed, including current work in progress to develop a full scale mockup and conduct usability evaluations.

  3. A virtual repository approach to clinical and utilization studies: application in mammography as alternative to a national database.

    Science.gov (United States)

    Ohno-Machado, L; Boxwala, A A; Ehresman, J; Smith, D N; Greenes, R A

    1997-01-01

    A national mammography database was proposed, based on a centralized architecture for collecting, monitoring, and auditing mammography data. We have developed an alternative architecture relying on Internet-based distributed queries to heterogeneous databases. This architecture creates a "virtual repository", or a federated database which is constructed dynamically, for each query and makes use of data available in legacy systems. It allows the construction of custom-tailored databases at individual sites that can serve the dual purposes of providing data (a) to researchers through a common mammography repository and (b) to clinicians and administrators at participating institutions. We implemented this architecture in a prototype system at the Brigham and Women's Hospital to show its feasibility. Common queries are translated dynamically into database-specific queries, and the results are aggregated for immediate display or download by the user. Data reside in two different databases and consist of structured mammography reports, coded per BIRADS Standardized Mammography Lexicon, as well as pathology results. We prospectively collected data on 213 patients, and showed that our system can perform distributed queries effectively. We also implemented graphical exploratory analysis tools to allow visualization of results. Our findings indicate that the architecture is not only feasible, but also flexible and scaleable, constituting a good alternative to a national mammography database. PMID:9357650

  4. An alternative approach to the Army Physical Fitness Test two-mile run using critical velocity and isoperformance curves.

    Science.gov (United States)

    Fukuda, David H; Smith, Abbie E; Kendall, Kristina L; Cramer, Joel T; Stout, Jeffrey R

    2012-02-01

    The purpose of this study was to evaluate the use of critical velocity (CV) and isoperformance curves as an alternative to the Army Physical Fitness Test (APFT) two-mile running test. Seventy-eight men and women (mean +/- SE; age: 22.1 +/- 0.34 years; VO2(MAX): 46.1 +/- 0.82 mL/kg/min) volunteered to participate in this study. A VO2(MAX) test and four treadmill running bouts to exhaustion at varying intensities were completed. The relationship between total distance and time-to-exhaustion was tracked for each exhaustive run to determine CV and anaerobic running capacity. A VO2(MAX) prediction equation (Coefficient of determination: 0.805; Standard error of the estimate: 3.2377 mL/kg/min) was developed using these variables. Isoperformance curves were constructed for men and women to correspond with two-mile run times from APFT standards. Individual CV and anaerobic running capacity values were plotted and compared to isoperformance curves for APFT 2-mile run scores. Fifty-four individuals were determined to receive passing scores from this assessment. Physiological profiles identified from this procedure can be used to assess specific aerobic or anaerobic training needs. With the use of time-to-exhaustion as opposed to a time-trial format used in the two-mile run test, pacing strategies may be limited. The combination of variables from the CV test and isoperformance curves provides an alternative to standardized time-trial testing.

  5. Implementation of image-guided brachytherapy (IGBT) for patients with uterine cervix cancer: a tumor volume kinetics approach

    Science.gov (United States)

    Mendez, Lucas Castro; Stuart, Silvia Radwanski; Guimarães, Roger Guilherme Rodrigues; Ramos, Clarissa Cerchi Angotti; de Paula, Lucas Assad; de Sales, Camila Pessoa; Chen, André Tsin Chih; Blasbalg, Roberto; Baroni, Ronaldo Hueb

    2016-01-01

    Purpose To evaluate tumor shrinking kinetics in order to implement image-guided brachytherapy (IGBT) for the treatment of patients with cervix cancer. Material and methods This study has prospectively evaluated tumor shrinking kinetics of thirteen patients with uterine cervix cancer treated with combined chemoradiation. Four high dose rate brachytherapy fractions were delivered during the course of pelvic external beam radiation therapy (EBRT). Magnetic resonance imaging (MRI) exams were acquired at diagnosis (D), first (B1), and third (B3) brachytherapy fractions. Target volumes (GTV and HR-CTV) were calculated by both the ellipsoid formula (VE) and MRI contouring (VC), which were defined by a consensus between at least two radiation oncologists and a pelvic expert radiologist. Results Most enrolled patients had squamous cell carcinoma and FIGO stage IIB disease, and initiated brachytherapy after the third week of pelvic external beam radiation. Gross tumor volume volume reduction from diagnostic MRI to B1 represented 61.9% and 75.2% of the initial volume, when measured by VE and VC, respectively. Only a modest volume reduction (15-20%) was observed from B1 to B3. Conclusions The most expressive tumor shrinking occurred in the first three weeks of oncological treatment and was in accordance with gynecological examination. These findings may help in IGBT implementation. PMID:27648083

  6. Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.

    Science.gov (United States)

    Chaikuad, Apirat; Knapp, Stefan; von Delft, Frank

    2015-08-01

    The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially available crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant. PMID:26249344

  7. The influence of expert opinions on the selection of wastewater treatment alternatives: a group decision-making approach.

    Science.gov (United States)

    Kalbar, Pradip P; Karmakar, Subhankar; Asolekar, Shyam R

    2013-10-15

    The application of multiple-attribute decision-making (MADM) to real life decision problems suggests that avoiding the loss of information through scenario-based approaches and including expert opinions in the decision-making process are two major challenges that require more research efforts. Recently, a wastewater treatment technology selection effort has been made with a 'scenario-based' method of MADM. This paper focuses on a novel approach to incorporate expert opinions into the scenario-based decision-making process, as expert opinions play a major role in the selection of treatment technologies. The sets of criteria and the indicators that are used consist of both qualitative and quantitative criteria. The group decision-making (GDM) approach that is implemented for aggregating expert opinions is based on an analytical hierarchy process (AHP), which is the most widely used MADM method. The pairwise comparison matrices (PCMs) for qualitative criteria are formed based on expert opinions, whereas, a novel approach is proposed for generating PCMs for quantitative criteria. It has been determined that the experts largely prefer natural treatment systems because they are more sustainable in any scenario. However, PCMs based on expert opinions suggest that advanced technologies such as the sequencing batch reactor (SBR) can also be appropriate for a given decision scenario. The proposed GDM approach is a rationalized process that will be more appropriate in realistic scenarios where multiple stakeholders with local and regional societal priorities are involved in the selection of treatment technology. PMID:23872214

  8. The influence of expert opinions on the selection of wastewater treatment alternatives: a group decision-making approach.

    Science.gov (United States)

    Kalbar, Pradip P; Karmakar, Subhankar; Asolekar, Shyam R

    2013-10-15

    The application of multiple-attribute decision-making (MADM) to real life decision problems suggests that avoiding the loss of information through scenario-based approaches and including expert opinions in the decision-making process are two major challenges that require more research efforts. Recently, a wastewater treatment technology selection effort has been made with a 'scenario-based' method of MADM. This paper focuses on a novel approach to incorporate expert opinions into the scenario-based decision-making process, as expert opinions play a major role in the selection of treatment technologies. The sets of criteria and the indicators that are used consist of both qualitative and quantitative criteria. The group decision-making (GDM) approach that is implemented for aggregating expert opinions is based on an analytical hierarchy process (AHP), which is the most widely used MADM method. The pairwise comparison matrices (PCMs) for qualitative criteria are formed based on expert opinions, whereas, a novel approach is proposed for generating PCMs for quantitative criteria. It has been determined that the experts largely prefer natural treatment systems because they are more sustainable in any scenario. However, PCMs based on expert opinions suggest that advanced technologies such as the sequencing batch reactor (SBR) can also be appropriate for a given decision scenario. The proposed GDM approach is a rationalized process that will be more appropriate in realistic scenarios where multiple stakeholders with local and regional societal priorities are involved in the selection of treatment technology.

  9. Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens

    Energy Technology Data Exchange (ETDEWEB)

    Chaikuad, Apirat, E-mail: apirat.chaikuad@sgc.ox.ac.uk [University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ (United Kingdom); Knapp, Stefan [University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ (United Kingdom); Johann Wolfgang Goethe-University, Building N240 Room 3.03, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main (Germany); Delft, Frank von, E-mail: apirat.chaikuad@sgc.ox.ac.uk [University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ (United Kingdom)

    2015-07-28

    An alternative strategy for PEG sampling is suggested through the use of four newly defined PEG smears to enhance chemical space in reduced screens with a benefit towards protein crystallization. The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially available crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant.

  10. DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences

    Directory of Open Access Journals (Sweden)

    Gaëlle Lenglet

    2010-01-01

    Full Text Available DNA targeting drugs represent a large proportion of the actual anticancer drug pharmacopeia, both in terms of drug brands and prescription volumes. Small DNA-interacting molecules share the ability of certain proteins to change the DNA helix's overall organization and geometrical orientation via tilt, roll, twist, slip, and flip effects. In this ocean of DNA-interacting compounds, most stabilize both DNA strands and very few display helix-destabilizing properties. These types of DNA-destabilizing effect are observed with certain mono- or bis-intercalators and DNA alkylating agents (some of which have been or are being developed as cancer drugs. The formation of locally destabilized DNA portions could interfere with protein/DNA recognition and potentially affect several crucial cellular processes, such as DNA repair, replication, and transcription. The present paper describes the molecular basis of DNA destabilization, the cellular impact on protein recognition, and DNA repair processes and the latter's relationships with antitumour efficacy.

  11. Alternative security

    International Nuclear Information System (INIS)

    This book contains the following chapters: The Military and Alternative Security: New Missions for Stable Conventional Security; Technology and Alternative Security: A Cherished Myth Expires; Law and Alternative Security: Toward a Just World Peace; Politics and Alternative Security: Toward a More Democratic, Therefore More Peaceful, World; Economics and Alternative Security: Toward a Peacekeeping International Economy; Psychology and Alternative Security: Needs, Perceptions, and Misperceptions; Religion and Alternative Security: A Prophetic Vision; and Toward Post-Nuclear Global Security: An Overview

  12. DNA-synthesis inhibition and repair DNA-synthesis in CHO Ade- C cells: An alternative approach to genotoxicity testing

    International Nuclear Information System (INIS)

    We describe an alternative assay to determine genotoxicity. Its main feature is that it combines two measures in a single experiment; the inhibition of replicative DNA synthesis together with the stimulation of DNA repair. We show that, in tests of four different genotoxic agents, the assay gives results that are entirely consistent with what is known about the mode of action of these agents. In addition, we have demonstrated that chemical carcinogens requiring metabolic activation can be examined using a standard procedure of incubation with a microsomal activating fraction. We consider the combined assay for DNA synthesis inhibition and repair synthesis to be a useful way for the rapid pre-screening of chemicals suspected of genotoxic activity on the level of mammalian cells. (author)

  13. An alternative approach to monitoring fish and fish habitat in the inland Northwest: Annual report 1999; ANNUAL

    International Nuclear Information System (INIS)

    The development of efficient and effective monitoring protocols will depend, in part, upon successfully incorporating multiple research and management goals across several disciplines. Decision analysis has these abilities and can be used to examine the potential effects of alternative management activities, identify candidate monitoring variables, and estimate the value of monitoring or conducting additional studies. The author demonstrates the utility of decision analysis for monitoring and adaptive (i.e., experimental) management with an example of a timber harvest decision. Example models were generated using previously reported relationships and Monte Carlo simulation and the value of sampling (e.g., monitoring) was estimated via Baye's Rule. He concludes that the decision analysis can be a powerful tool for developing a future effectiveness monitoring protocols and should be considered by natural resource managers prior to adopting a monitoring strategy

  14. Reconciling alternate methods for the determination of charge distributions: A probabilistic approach to high-dimensional least-squares approximations

    CERN Document Server

    Champagnat, Nicolas; Faou, Erwan

    2010-01-01

    We propose extensions and improvements of the statistical analysis of distributed multipoles (SADM) algorithm put forth by Chipot et al. in [6] for the derivation of distributed atomic multipoles from the quantum-mechanical electrostatic potential. The method is mathematically extended to general least-squares problems and provides an alternative approximation method in cases where the original least-squares problem is computationally not tractable, either because of its ill-posedness or its high-dimensionality. The solution is approximated employing a Monte Carlo method that takes the average of a random variable defined as the solutions of random small least-squares problems drawn as subsystems of the original problem. The conditions that ensure convergence and consistency of the method are discussed, along with an analysis of the computational cost in specific instances.

  15. An alternative discourse of productive aging: A self-restrained approach in older Chinese people in Hong Kong.

    Science.gov (United States)

    Luo, Minxia; Chui, Ernest Wing-Tak

    2016-08-01

    While Western discourses regarding productive aging emphasize individuals' contributions to economic productivity, the Confucian cultural heritage of the Chinese community may provide an alternative perspective. This qualitative study explores interpretations of what constitutes productive aging, based on a series of in-depth interviews with older Chinese people in Hong Kong. It shows that some of these individuals adopted a passive and indirect interpretation of productive aging, distinct from that found in Western countries. The Confucianism-based, collectivist, normative order underpinning Hong Kong society disposed these older people to adopting a self-restrained attitude with the aim of avoiding becoming a burden to others, especially family members. Such a tendency toward self-restraint or avoidance also encompassed a compromise between ideals and reality, with the older people opting to compromise their expectations of the younger generation as a whole, their adult children in particular, in terms of respect and reciprocity.

  16. An alternative discourse of productive aging: A self-restrained approach in older Chinese people in Hong Kong.

    Science.gov (United States)

    Luo, Minxia; Chui, Ernest Wing-Tak

    2016-08-01

    While Western discourses regarding productive aging emphasize individuals' contributions to economic productivity, the Confucian cultural heritage of the Chinese community may provide an alternative perspective. This qualitative study explores interpretations of what constitutes productive aging, based on a series of in-depth interviews with older Chinese people in Hong Kong. It shows that some of these individuals adopted a passive and indirect interpretation of productive aging, distinct from that found in Western countries. The Confucianism-based, collectivist, normative order underpinning Hong Kong society disposed these older people to adopting a self-restrained attitude with the aim of avoiding becoming a burden to others, especially family members. Such a tendency toward self-restraint or avoidance also encompassed a compromise between ideals and reality, with the older people opting to compromise their expectations of the younger generation as a whole, their adult children in particular, in terms of respect and reciprocity. PMID:27531450

  17. Deciphering the plant splicing code: Experimental and computational approaches for predicting alternative splicing and splicing regulatory elements

    Directory of Open Access Journals (Sweden)

    Anireddy S.N. Reddy

    2012-02-01

    Full Text Available Extensive alternative splicing (AS of precursor mRNAs (pre-mRNAs in multicellular eukaryotes increases the protein-coding capacity of a genome and allows novel ways to regulate gene expression. In fowering plants, up to 48% of intron-containing genes exhibit AS. However, the full extent of AS in plants is not yet known, as only a few high throughput RNA-Seq studies have been performed. As the cost of obtaining RNA-Seq reads continues to fall, it is anticipated that huge amounts of plant sequence data will accumulate and help in obtaining a more complete picture of AS in plants. Although it is not an onerous task to obtain hundreds of millions of reads using high throughput sequencing technologies, computational tools to accurately predict and visualize AS are still being developed and refined. This review will discuss the tools to predict and visualize transcriptome-wide AS in plants using short reads and highlight their limitations. Comparative studies of AS events between plants and animals have revealed that there are major differences in the most prevalent types of AS events, suggesting that plants and animals differ in the way they recognize exons and introns. Extensive studies have been performed in animals to identify cis-elements involved in regulating AS, especially in exon skipping. However, such studies are in their infancy in plants. Here, we review the current state of research on splicing regulatory elements (SREs and briefly discuss emerging experimental and computational tools to identify cis-elements involved in regulation of AS in plants. The availability of curated alternative splice forms in plants makes it possible to use computational tools to predict SREs involved in AS regulation, which can then be verified experimentally. Such studies will permit identification of plant-specific features involved in AS regulation and contribute to deciphering the splicing code in plants.

  18. The Civic-Minded Instructional Designers Framework: An Alternative Approach to Contemporary Instructional Designers' Education in Higher Education

    Science.gov (United States)

    Yusop, Farrah Dina; Correia, Ana-Paula

    2012-01-01

    This paper argues that an emphasis on training-for-the-job approaches has distracted designers from thinking about the meaning of their profession and the grand purpose of practising instructional design. Drawing from literature in the fields of sociology and educational technology, this paper synthesises discourses on civic professionalism in…

  19. Alternatives for Mixed-Effects Meta-Regression Models in the Reliability Generalization Approach: A Simulation Study

    Science.gov (United States)

    López-López, José Antonio; Botella, Juan; Sánchez-Meca, Julio; Marín-Martínez, Fulgencio

    2013-01-01

    Since heterogeneity between reliability coefficients is usually found in reliability generalization studies, moderator analyses constitute a crucial step for that meta-analytic approach. In this study, different procedures for conducting mixed-effects meta-regression analyses were compared. Specifically, four transformation methods for the…

  20. New volume and inverse volume operators for loop quantum gravity

    CERN Document Server

    Yang, Jinsong

    2016-01-01

    A new alternative volume operator is constructed for loop quantum gravity by using the so-called co-triad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The new inverse volume operator can be employed to construct the Hamiltonian operator of matter fields, which may lead to an anomaly-free on shell quantum constraint algebra without any special restriction on the regularization procedure for gravity coupled to matter fields.

  1. New volume and inverse volume operators for loop quantum gravity

    Science.gov (United States)

    Yang, Jinsong; Ma, Yongge

    2016-08-01

    A new alternative volume operator is constructed for loop quantum gravity by using the so-called cotriad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The new inverse volume operator can be employed to construct the Hamiltonian operator of matter fields, which may lead to an anomaly-free on-shell quantum constraint algebra without any special restriction on the regularization procedure for gravity coupled to matter fields.

  2. Measuring population health: costs of alternative survey approaches in the Nouna Health and Demographic Surveillance System in rural Burkina Faso

    Directory of Open Access Journals (Sweden)

    Henrike Lietz

    2015-08-01

    Full Text Available Background: There are more than 40 Health and Demographic Surveillance System (HDSS sites in 19 different countries. The running costs of HDSS sites are high. The financing of HDSS activities is of major importance, and adding external health surveys to the HDSS is challenging. To investigate the ways of improving data quality and collection efficiency in the Nouna HDSS in Burkina Faso, the stand-alone data collection activities of the HDSS and the Household Morbidity Survey (HMS were integrated, and the paper-based questionnaires were consolidated into a single tablet-based questionnaire, the Comprehensive Disease Assessment (CDA. Objective: The aims of this study are to estimate and compare the implementation costs of the two different survey approaches for measuring population health. Design: All financial costs of stand-alone (HDSS and HMS and integrated (CDA surveys were estimated from the perspective of the implementing agency. Fixed and variable costs of survey implementation and key cost drivers were identified. The costs per household visit were calculated for both survey approaches. Results: While fixed costs of survey implementation were similar for the two survey approaches, there were considerable variations in variable costs, resulting in an estimated annual cost saving of about US$45,000 under the integrated survey approach. This was primarily because the costs of data management for the tablet-based CDA survey were considerably lower than for the paper-based stand-alone surveys. The cost per household visit from the integrated survey approach was US$21 compared with US$25 from the stand-alone surveys for collecting the same amount of information from 10,000 HDSS households. Conclusions: The CDA tablet-based survey method appears to be feasible and efficient for collecting health and demographic data in the Nouna HDSS in rural Burkina Faso. The possibility of using the tablet-based data collection platform to improve the quality

  3. Lesson Plans for the Busy Librarian: A Standards Based Approach for the Elementary Library Media Center, Volume 2

    Science.gov (United States)

    Keeling, Joyce

    2005-01-01

    The author designed this book, like Volume I of the set, to give elementary school librarians a quick, enjoyable way to coordinate with teachers to teach information literacy and literacy skills aligned with national standards. The chapters in the book include: (1) Kindergarten Lesson Plans; (2) First-Grade Lesson Plans; (3) Second-Grade Lesson…

  4. Volume Overload Cleanup: An Approach for On-line SPE-GC, GPC-GC and GPC-SPE-GC

    NARCIS (Netherlands)

    Kerkdijk, H.; Mol, J.G.J.; Nagel, van der B.

    2007-01-01

    A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determi

  5. Volume overload cleanup: An approach for on-line SPE-GC, GPC-GC, and GPC-SPE-GC

    NARCIS (Netherlands)

    Kerkdijk, H.; Mol, H.G.J.; Nagel, B. van der

    2007-01-01

    A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determi

  6. APPROACHES TO SEMIOTICS. TRANSACTIONS OF THE INDIANA UNIVERSITY CONFERENCE ON PARALINGUISTICS AND KINESICS. JANUA LINGUARUM SERIES MAIOR, VOLUME XV.

    Science.gov (United States)

    SEBEOK, THOMAS A.; AND OTHERS

    THE SIX PAPERS IN THIS VOLUME ARE THE RESULT OF THE 1962 CONFERENCE ON PARALINGUISTICS AND KINESICS, ORGANIZED BY THOMAS A. SEBEOK AND SPONSORED BY THE UNIVERSITY OF INDIANA RESEARCH CENTER IN ANTHROPOLOGY, FOLKLORE, AND LINGUISTICS. THE PURPOSE OF THE CONFERENCE WAS TO EXPLORE THE INTERACTIONAL AND COMMUNICATIONAL CONTEXT OF THE HUMAN USE OF…

  7. The play approach to learning in the context of families and schools: an alternative paradigm for nutrition and fitness education in the 21st century.

    Science.gov (United States)

    Rickard, K A; Gallahue, D L; Gruen, G E; Tridle, M; Bewley, N; Steele, K

    1995-10-01

    An alternative paradigm for nutrition and fitness education centers on understanding and developing skill in implementing a play approach to learning about healthful eating and promoting active play in the context of the child, the family, and the school. The play approach is defined as a process for learning that is intrinsically motivated, enjoyable, freely chosen, nonliteral, safe, and actively engaged in by young learners. Making choices, assuming responsibility for one's decisions and actions, and having fun are inherent components of the play approach to learning. In this approach, internal cognitive transactions and intrinsic motivation are the primary forces that ultimately determine healthful choices and life habits. Theoretical models of children's learning--the dynamic systems theory and the cognitive-developmental theory of Jean Piaget--provide a theoretical basis for nutrition and fitness education in the 21st century. The ultimate goal is to develop partnerships of children, families, and schools in ways that promote the well-being of children and translate into healthful life habits. The play approach is an ongoing process of learning that is applicable to learners of all ages. PMID:7560683

  8. Positive psychology as an alternative to traditional clinical approach to study of quality of life in people with physical disabilities

    OpenAIRE

    Lebedeva A. A.

    2012-01-01

    The article is devoted to overview studies of quality of life in people with physical disabilities. The scientists are mainly focused on the health limitations as affecting their quality of life. As a fact, disabled people need regular medical help, procedures of rehabilitation and prophylaxis of medical consequences of their disability. This paper addresses the subject from the perspective of positive approaches to development of personality and quality of life in people with disabilities. P...

  9. AN ALTERNATIVE APPROACH FOR CHILD LABOUR IN DEVELOPING COUNTRIES: CHILD LABOUR PARTICIPATION RATES OR SCHOOL NON-ATTENDANCE RATES

    OpenAIRE

    Ozcan Dagdemir; Hakan Acaroglu

    2010-01-01

    Child labour widely measured by child labour participation rates in literature is considered by non-attendance rates in primary education in this study. Along with this approach, it is attempted to investigate in what closeness the child labour ratios of countries are also measured by school non-attendance rates. The data is collected from UNICEF and World Bank. 85 developing countries take part in cross-country analysis by ordinary least square technique. The time period interval is 2000-200...

  10. ALTERNATIVE APPROACH IN THE TREATMENT OF A GINGIVAL CLEFT ASSOCIATED WITH LABIAL FRENULUM. A 3-YEAR FOLLOW-UP. (Case Report

    Directory of Open Access Journals (Sweden)

    Kamen Kotsilkov

    2015-07-01

    Full Text Available INTRODUCTION: The term Gingival cleft refers to a fissure in the gingival tissues and is usually caused by traumatic oral hygiene, abnormal frenula, trauma from occlusion, orthodontic, or pierce related trauma. Gingival clefts are classified depending on the extent of the inclusion of the gingival thickness into red and white. The recommended treatment approach for the incomplete white clefts is the gingivectomy of the affected keratinized tissue followed by a coronally advanced flap for the root coveradge, while the complete white clefts are treated with a laterally moved, coronally advanced flap, or a free gingival graft procedure. OBJECTIVE: This report presents a case with a spontaneous healing of an incomplete gingival cleft associated with a maxillary labial frenulum after an alternative frenuloectomy approach. METHODS: M.G. (45 with a localized chronic periodontitis, an abnormal papillary maxillary frenulum and an incomplete white cleft on the marginal gingiva of the left central incisor. An alternative frenuloectomy approach combined with a free gingival graft was selected for the correction of the abnormal frenulum. RESULTS:On the sixth month after the surgical procedure an almost complete recovery of the gingival margin was observed.The result at the third year demonstrates a stable gingival margin with a complete tissue recovery. CONCLUSION: The applied combined surgical approach led to a complete gingival recovery of the incomplete white gingival cleft without the commonly used gingivectomy and CAF. Further research is recommended to clarify the adjunctive benefits of the FGG in patients with gingival clefts associated with abnormal frenula.

  11. An alternative approach for quantitative bioanalysis using diluted blood to profile oral exposure of small molecule anticancer drugs in mice.

    Science.gov (United States)

    Liederer, Bianca M; Berezhkovskiy, Leonid M; Ubhayakar, Savita S; Deng, Yuzhong

    2013-02-01

    A quantitative bioanalytical method for pharmacokinetic studies using diluted whole blood from serially bled mice was developed. Oral exposure profiles in mice for five model anticancer compounds dacarbazine, gefitinib, gemcitabine, imatinib, and topotecan were determined following discrete and cassette (five-in-one) dosing. Six micro blood samples per animal were collected and added to a fixed amount of water. This dilution served several purposes: the red blood cells were lysed; an anticoagulant was unnecessary and the fluid volume of diluted sample was sufficient for bioanalytical assays. AUC values obtained from blood concentrations were within twofold for discrete and cassette dosing except for imatinib (2.1-fold difference) and in agreement with those obtained from plasma concentrations after discrete dosing. All compounds were stable in plasma and diluted blood samples for at least 2 weeks at approximately -80°C. Matrix and intermatrix effects were evaluated to ensure robustness and integrity of the bioanalytical assays. This method provides significant process improvement by enhancing efficiency for sample collection and processing and reducing resources (e.g., reduced compound, cost, and animal requirement) compared with conventional methods. Our study demonstrates the applicability of using diluted micro blood samples for small molecule quantitative bioanalysis to support mouse studies in drug discovery. PMID:23225118

  12. An Alternative Approach to Synthesizing Galactooligosaccharides by Cell-Surface Display of β-Galactosidase on Yarrowia lipolytica.

    Science.gov (United States)

    An, Jin; Zhang, Lebin; Li, Lijuan; Liu, Dawen; Cheng, Huiling; Wang, Hengwei; Nawaz, Muhammad Zohaib; Cheng, Hairong; Deng, Zixin

    2016-05-18

    An alternative strategy for synthesizing galactooligosaccharides (GOS) from an erythritol-producing yeast Yarrowia lipolytica using surface display technology was demonstrated. The engineered strain CGMCC11369 was developed by fusion of the β-galactosidase gene from Aspergillus oryzae to the YlPir1 gene, which codes for a cell wall protein. β-Galactosidase was effectively displayed on the cell surface of Yarrowia lipolytica start strain CGMCC7326. This engineered strain with surface-displayed β-galactosidase efficiently synthesized GOS from lactose. An amount of 160 g/L GOS was produced within 6 h in a solution of 500 g/L lactose and 5 mg/mL cell (dry weight) at pH 5.5 and 60 °C, with a yield of 51% of consumed lactose monohydrate. This newly developed method was applied with waste yeast paste from erythritol industry at least 10 times. The optimal reaction temperature increased to 60 °C, about 20 °C higher than that of free β-galactosidase, which was helpful for enhancing the reaction rate and GOS production. PMID:27090877

  13. In vitro and in vivo inhibition of Streptococcus mutans biofilm by Trachyspermum ammi seeds: an approach of alternative medicine.

    Science.gov (United States)

    Khan, Rosina; Adil, Mohd; Danishuddin, Mohd; Verma, Praveen K; Khan, Asad U

    2012-06-15

    The aim of this study was to evaluate the influence of the crude and active solvent fraction of Trachyspermum ammi on S. mutans cariogenicity, effect on expression of genes involved in biofilm formation and caries development in rats. GC-MS was carried out to identify the major components present in the crude and the active fraction of T. ammi. The crude extract and the solvent fraction exhibiting least MIC were selected for further experiments. Scanning electron microscopy was carried out to observe the effect of the extracts on S. mutans biofilm. Comparative gene expression analysis was carried out for nine selected genes. 2-Isopropyl-5-methyl-phenol was found as major compound in crude and the active fraction. Binding site of this compound within the proteins involved in biofilm formation, was mapped with the help of docking studies. Real-time RT-PCR analyses revealed significant suppression of the genes involved in biofilm formation. All the test groups showed reduction in caries (smooth surface as well as sulcal surface caries) in rats. Moreover, it also provides new insight to understand the mechanism influencing biofilm formation in S. mutans. Furthermore, the data suggest the putative cariostatic properties of T. Ammi and hence can be used as an alternative medicine to prevent caries infection.

  14. Photodynamic therapy for angiosarcoma of scalp as alternative approach for surgical treatment in patient with severe co-morbidity

    Directory of Open Access Journals (Sweden)

    E. V. Yaroslavtseva-Isaeva

    2014-01-01

    Full Text Available A case of successful photodynamic therapy in patient of 86 y.o. with diagnosis: angiosarcoma of right temporal-parietal region stage IIA (Т2вN0M0 is reported. The tumor was as soft tissue round shape lesion with tuberous contours 3.4х3.4х1.1 cm in size, located in subcutaneous tissue in right parietal region with no scull bone invasion. The patient was refused to surgical treatment with general anesthesia due to severe cardiovascular co-morbidity. The patient underwent a course of photodynamic therapy with Photolon. The photosensitizer was intravenousely introduced for 3 h before irradiation at dose of 1 mg/kg body weight. The parameters of irradiation were as follows: output power – 0.8 W, light dose – 150 J/cm2, 4 irradiation fields 2.5 cm in diameter. During the irradiation there were moderate pain which did not require drug management. After PDT complete regression of the tumor was achieved. For nowadays (11 months after treatment the patient is observed with no recurrence. The reported case shows that photodynamic therapy may be successfully used for alternative treatment of soft tissue angiosarcoma in patients with no ability for surgical treatment. 

  15. Toward an Alternative Therapeutic Approach for Skin Infections: Antagonistic Activity of Lactobacilli Against Antibiotic-Resistant Staphylococcus aureus and Pseudomonas aeruginosa.

    Science.gov (United States)

    Hafez, Mohamed M; Maghrabi, Ibrahim A; Zaki, Noha M

    2013-09-01

    The wide spread of antimicrobial resistance has urged the need of alternative therapeutic approach. In this context, probiotic lactobacilli have been reported for the prevention and treatment of many gastrointestinal and urogenital infections. However, very little is known about their antagonistic activity against skin pathogens. Accordingly, the present study aimed to investigate the potential of lactobacilli to interfere with pathogenesis features of two antibiotic-resistant skin pathogens, namely methicillin-resistant Staphylococcus aureus and multiple-resistant Pseudomonas aeruginosa. A total of 49 lactobacilli were recovered, identified and tested for their antagonistic activities against the aforementioned pathogens. Of these, eight isolates were capable of blocking the adherence of pathogens to mammalian cells independent of the skin pathogen tested or model adopted. Moreover, three Lactobacillus isolates (LRA4, LC2 and LR5) effectively prevented the pathogen internalization into epithelial cells in addition to potentiating phagocyte-mediated pathogen killing. Interestingly, the lactobacilli LC2, LF9 and LRA4 markedly inhibited the growth of P. aeruginosa and S. aureus isolates in coculture experiments. Besides, the lactobacilli LRA4, LC2, LR5 and LF9 have counteracted pathogen cytotoxicity. Taken together, the present study revealed some inhibitory activities of lactobacilli against two antibiotic-resistant skin pathogens. Moreover, it revealed two lactobacilli, namely LC2 and LRA4, with antagonistic capacity against different virulence determinants of skin pathogens. These lactobacilli are considered promising probiotic candidates that may represent an alternative therapeutic approach for skin infections.

  16. Alternative energies; Energies alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Bonal, J.; Rossetti, P

    2007-07-01

    The earth took millions years to made the petroleum, the gas the coal and the uranium. Only a few centuries will be needed to exhaust these fossil fuels and some years to reach expensive prices. Will the wold continue on this way of energy compulsive consumption? The renewable energies and some citizen attitudes are sufficient to break this spiral. This book proposes to discuss these alternative energies. It shows that this attitude must be supported by the government. It takes stock on the more recent information concerning the renewable energies. it develops three main points: the electricity storage, the housing and the transports. (A.L.B.)

  17. An alternative approach to approximate entropy threshold value (r) selection: application to heart rate variability and systolic blood pressure variability under postural challenge.

    Science.gov (United States)

    Singh, A; Saini, B S; Singh, D

    2016-05-01

    This study presents an alternative approach to approximate entropy (ApEn) threshold value (r) selection. There are two limitations of traditional ApEn algorithm: (1) the occurrence of undefined conditional probability (CPu) where no template match is found and (2) use of a crisp tolerance (radius) threshold 'r'. To overcome these limitations, CPu is substituted with optimum bias setting ɛ opt which is found by varying ɛ from (1/N - m) to 1 in the increments of 0.05, where N is the length of the series and m is the embedding dimension. Furthermore, an alternative approach for selection of r based on binning the distance values obtained by template matching to calculate ApEnbin is presented. It is observed that ApEnmax, ApEnchon and ApEnbin converge for ɛ opt = 0.6 in 50 realizations (n = 50) of random number series of N = 300. Similar analysis suggests ɛ opt = 0.65 and ɛ opt = 0.45 for 50 realizations each of fractional Brownian motion and MIX(P) series (Lu et al. in J Clin Monit Comput 22(1):23-29, 2008). ɛ opt = 0.5 is suggested for heart rate variability (HRV) and systolic blood pressure variability (SBPV) signals obtained from 50 young healthy subjects under supine and upright position. It is observed that (1) ApEnbin of HRV is lower than SBPV, (2) ApEnbin of HRV increases from supine to upright due to vagal inhibition and (3) ApEnbin of BPV decreases from supine to upright due to sympathetic activation. Moreover, merit of ApEnbin is that it provides an alternative to the cumbersome ApEnmax procedure. PMID:26253284

  18. Improving clinical outcomes among hemodialysis patients: a proposal for a "volume first" approach from the chief medical officers of US dialysis providers.

    Science.gov (United States)

    Weiner, Daniel E; Brunelli, Steven M; Hunt, Abigail; Schiller, Brigitte; Glassock, Richard; Maddux, Frank W; Johnson, Douglas; Parker, Tom; Nissenson, Allen

    2014-11-01

    Addressing fluid intake and volume control requires alignment and coordination of patients, providers, dialysis facilities, and payers, potentially necessitating a "Volume First" approach. This article reports the consensus opinions achieved at the March 2013 symposium of the Chief Medical Officers of 14 of the largest dialysis providers in the United States. These opinions are based on broad experience among participants, but often reinforced by only observational and frequently retrospective studies, highlighting the lack of high-quality clinical trials in nephrology. Given the high morbidity and mortality rates among dialysis patients and the absence of sufficient trial data to guide most aspects of hemodialysis therapy, participants believed that immediate attempts to improve care based on quality improvement initiatives, physiologic principles, and clinical experiences are warranted until such time as rigorous clinical trial data become available. The following overarching consensus opinions emerged. (1) Extracellular fluid status should be a component of sufficient dialysis, such that approaching normalization of extracellular fluid volume should be a primary goal of dialysis care. (2) Fluid removal should be gradual and dialysis treatment duration should not routinely be less than 4 hours without justification based on individual patient factors. (3) Intradialytic sodium loading should be avoided by incorporating dialysate sodium concentrations set routinely in the range of 134-138 mEq/L, avoidance of routine use of sodium modeling, and avoidance of hypertonic saline solution. (4) Dietary counseling should emphasize sodium avoidance.

  19. Theoretical approach to study the effect of free volumes on the physical behavior of polymer stabilized ferroelectric liquid crystal molecules

    Science.gov (United States)

    Lahiri, T.; Majumder, T. Pal

    2011-06-01

    It was clearly indicative that the polymer chains make a tremendous interaction with the tilt angle in case of a polymer stabilized ferroelectric liquid crystal (PSFLC). After suitable consideration of such interaction, we expanded the Landau free energy for a PSFLC system. We theoretically demonstrated the effect of free volumes, which expected to create bulk self-energy, on the physical functionalities of a PSFLC system. Then we obtained spontaneous polarization, tilt angle, rotational viscosity and dielectric constant strongly correlated with the assumed interactions. We also observed a shift of transition temperature highly influenced by this interaction between polymer network and liquid crystal molecules. A microscopical picture of this polymer-liquid crystal interaction is provided in view of the free volume charge density present in the composite system.

  20. An artificial intelligence approach for modeling volume and fresh weight of callus - A case study of cumin (Cuminum cyminum L.).

    Science.gov (United States)

    Mansouri, Ali; Fadavi, Ali; Mortazavian, Seyed Mohammad Mahdi

    2016-05-21

    Cumin (Cuminum cyminum Linn.) is valued for its aroma and its medicinal and therapeutic properties. A supervised feedforward artificial neural network (ANN) trained with back propagation algorithms, was applied to predict fresh weight and volume of Cuminum cyminum L. calli. Pearson correlation coefficient was used to evaluate input/output dependency of the eleven input parameters. Area, feret diameter, minor axis length, perimeter and weighted density parameters were chosen as input variables. Different training algorithms, transfer functions, number of hidden nodes and training iteration were studied to find out the optimum ANN structure. The network with conjugate gradient fletcher-reeves (CGF) algorithm, tangent sigmoid transfer function, 17 hidden nodes and 2000 training epochs was selected as the final ANN model. The final model was able to predict the fresh weight and volume of calli more precisely relative to multiple linear models. The results were confirmed by R(2)≥0.89, R(i)≥0.94 and T value ≥0.86. The results for both volume and fresh weight values showed that almost 90% of data had an acceptable absolute error of ±5%. PMID:26987421

  1. An artificial intelligence approach for modeling volume and fresh weight of callus - A case study of cumin (Cuminum cyminum L.).

    Science.gov (United States)

    Mansouri, Ali; Fadavi, Ali; Mortazavian, Seyed Mohammad Mahdi

    2016-05-21

    Cumin (Cuminum cyminum Linn.) is valued for its aroma and its medicinal and therapeutic properties. A supervised feedforward artificial neural network (ANN) trained with back propagation algorithms, was applied to predict fresh weight and volume of Cuminum cyminum L. calli. Pearson correlation coefficient was used to evaluate input/output dependency of the eleven input parameters. Area, feret diameter, minor axis length, perimeter and weighted density parameters were chosen as input variables. Different training algorithms, transfer functions, number of hidden nodes and training iteration were studied to find out the optimum ANN structure. The network with conjugate gradient fletcher-reeves (CGF) algorithm, tangent sigmoid transfer function, 17 hidden nodes and 2000 training epochs was selected as the final ANN model. The final model was able to predict the fresh weight and volume of calli more precisely relative to multiple linear models. The results were confirmed by R(2)≥0.89, R(i)≥0.94 and T value ≥0.86. The results for both volume and fresh weight values showed that almost 90% of data had an acceptable absolute error of ±5%.

  2. White River Falls Fish Passage Project, Tygh Valley, Oregon : Final Technical Report, Volume III, Appendix B, Fisheries Report; Appendix C, Engineering Alternative Evaluation; Appendix D, Benefit/Cost Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Oregon. Dept. of Fish and Wildlife; Mount Hood National Forest (Or.)

    1985-06-01

    Studies were conducted to describe current habitat conditions in the White River basin above White River Falls and to evaluate the potential to produce anadromous fish. An inventory of spawning and rearing habitats, irrigation diversions, and enhancement opportunities for anadromous fish in the White River drainage was conducted. Survival of juvenile fish at White River Falls was estimated by releasing juvenile chinook and steelhead above the falls during high and low flow periods and recapturing them below the falls in 1983 and 1984. Four alternatives to provide upstream passage for adult salmon and steelhead were developd to a predesign level. The cost of adult passage and the estimated run size of anadromous fish were used to determine the benefit/cost of the preferred alternative. Possible effects of the introduction of anadromous fish on resident fish and on nearby Oak Springs Hatchery were evaluated. This included an inventory of resident species, a genetic study of native rainbow, and the identification of fish diseases in the basin. This volume contains appendices of habitat survey data, potential production, resident fish population data, upstream passage designs, and benefit/cost calculations. (ACR)

  3. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis.

    Science.gov (United States)

    Pfuhler, Stefan; Kirst, Annette; Aardema, Marilyn; Banduhn, Norbert; Goebel, Carsten; Araki, Daisuke; Costabel-Farkas, Margit; Dufour, Eric; Fautz, Rolf; Harvey, James; Hewitt, Nicola J; Hibatallah, Jalila; Carmichael, Paul; Macfarlane, Martin; Reisinger, Kerstin; Rowland, Joanna; Schellauf, Florian; Schepky, Andreas; Scheel, Julia

    2010-01-01

    For the assessment of genotoxic effects of cosmetic ingredients, a number of well-established and regulatory accepted in vitro assays are in place. A caveat to the use of these assays is their relatively low specificity and high rate of false or misleading positive results. Due to the 7th amendment to the EU Cosmetics Directive ban on in vivo genotoxicity testing for cosmetics that was enacted March 2009, it is no longer possible to conduct follow-up in vivo genotoxicity tests for cosmetic ingredients positive in in vitro genotoxicity tests to further assess the relevance of the in vitro findings. COLIPA, the European Cosmetics Association, has initiated a research programme to improve existing and develop new in vitro methods. A COLIPA workshop was held in Brussels in April 2008 to analyse the best possible use of available methods and approaches to enable a sound assessment of the genotoxic hazard of cosmetic ingredients. Common approaches of cosmetic companies are described, with recommendations for evaluating in vitro genotoxins using non-animal approaches. A weight of evidence approach was employed to set up a decision-tree for the integration of alternative methods into tiered testing strategies. PMID:20382194

  4. An Alternative Humans to Mars Approach: Reducing Mission Mass with Multiple Mars Flyby Trajectories and Minimal Capability Investments

    Science.gov (United States)

    Whitley, Ryan J.; Jedrey, Richard; Landau, Damon; Ocampo, Cesar

    2015-01-01

    Mars flyby trajectories and Earth return trajectories have the potential to enable lower- cost and sustainable human exploration of Mars. Flyby and return trajectories are true minimum energy paths with low to zero post-Earth departure maneuvers. By emplacing the large crew vehicles required for human transit on these paths, the total fuel cost can be reduced. The traditional full-up repeating Earth-Mars-Earth cycler concept requires significant infrastructure, but a Mars only flyby approach minimizes mission mass and maximizes opportunities to build-up missions in a stepwise manner. In this paper multiple strategies for sending a crew of 4 to Mars orbit and back are examined. With pre-emplaced assets in Mars orbit, a transit habitat and a minimally functional Mars taxi, a complete Mars mission can be accomplished in 3 SLS launches and 2 Mars Flyby's, including Orion. While some years are better than others, ample opportunities exist within a given 15-year Earth-Mars alignment cycle. Building up a mission cadence over time, this approach can translate to Mars surface access. Risk reduction, which is always a concern for human missions, is mitigated by the use of flybys with Earth return (some of which are true free returns) capability.

  5. Economic hardship in childhood and adult health trajectories: An alternative approach to investigating life-course processes.

    Science.gov (United States)

    Shuey, Kim M; Willson, Andrea E

    2014-12-01

    In this study, we advance existing research on health as a life course process by conceptualizing and measuring both childhood disadvantage and health as dynamic processes in order to investigate the relationship between trajectories of early life socioeconomic conditions and trajectories of health in midlife. We utilize a trajectory-based analysis that takes a disaggregated, person-centered approach to understand dynamic trajectories of health as latent variables that reflect the timing, duration and change in health conditions experienced by respondents over a period of 10 years in midlife as a function of stability and change in exposure to economic hardship in early life. Results from repeated-measures latent class analysis of longitudinal data from the Panel Study of Income Dynamics indicate that economic hardship in childhood has long-term, negative consequences for health both among individuals beginning life and remaining in poverty as well as those moving into poverty. In contrast, adults with more advantaged early life experiences, or who moved out of poverty during the period of observation, were at a lower risk of experiencing health trajectories characterized by the early onset or increasing risk of disease. We argue that a person-centered, disaggregated approach to the study of the relationship between socioeconomic status and health across the life course holds potential for the study of health inequality and that a greater focus on trajectory-based analysis is needed.

  6. A digital approach to fabricating an abutment replica to control cement volume in a cement-retained implant prosthesis.

    Science.gov (United States)

    Lee, Ju-Hyoung; Park, In-Sook; Sohn, Dong-Seok

    2016-07-01

    If a cement-retained implant prosthesis is placed on an abutment, excess cement should be minimized or removed to prevent periimplant inflammation. Various methods for fabricating an abutment replica have been introduced to maintain tissue health and reduce clean-up time. The purpose of this article is to present an alternative technique for fabricating an abutment replica with computer-aided design/computer-aided manufacturing (CAD/CAM) technology. PMID:26946917

  7. Guidelines for selecting codes for ground-water transport modeling of low-level waste burial sites. Volume 1. Guideline approach

    International Nuclear Information System (INIS)

    This document was written for the National Low-Level Waste Management Program to provide guidance for managers and site operators who need to select ground-water transport codes for assessing shallow-land burial site performance. The guidance given in this report also serves the needs of applications-oriented users who work under the direction of a manager or site operator. The guidelines are published in two volumes designed to support the needs of users having different technical backgrounds. An executive summary, published separately, gives managers and site operators an overview of the main guideline report. This volume includes specific recommendations for decision-making managers and site operators on how to use these guidelines. The more detailed discussions about the code selection approach are provided. 242 refs., 6 figs

  8. Guidelines for selecting codes for ground-water transport modeling of low-level waste burial sites. Volume 1. Guideline approach

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, C.S.; Cole, C.R.

    1985-05-01

    This document was written for the National Low-Level Waste Management Program to provide guidance for managers and site operators who need to select ground-water transport codes for assessing shallow-land burial site performance. The guidance given in this report also serves the needs of applications-oriented users who work under the direction of a manager or site operator. The guidelines are published in two volumes designed to support the needs of users having different technical backgrounds. An executive summary, published separately, gives managers and site operators an overview of the main guideline report. This volume includes specific recommendations for decision-making managers and site operators on how to use these guidelines. The more detailed discussions about the code selection approach are provided. 242 refs., 6 figs.

  9. Alternative additives; Alternative additiver

    Energy Technology Data Exchange (ETDEWEB)

    2007-08-15

    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is

  10. An alternative approach to indirect land use change: Allocating greenhouse gas effects among different uses of land

    International Nuclear Information System (INIS)

    Indirect land use change (iLUC) is hypothesized to occur when increasing demand for land due to bioenergy production displaces food and feed production onto new lands, thereby potentially producing large greenhouse gas emissions (GHG) during the land conversion event. Thus far, the totality of the projected iLUC effect has been assigned to biofuel production. In fact, multiple drivers of land use change exist and the resulting GHG releases should, in fairness, be allocated among these drivers. It seems more useful and intellectually rigorous to allocate potential land use change effects among these many drivers. This paper focuses on how to allocate the environmental consequences of iLUC to the multiple drivers through a function-oriented approach, namely human nutritional requirements for calories and protein. “Food versus Biofuel” issues can then be more usefully addressed as “Nutrition versus Biofuel” issues. Human beings actually have many choices in how we provide ourselves with adequate diets, and these choices have very different GHG and land use consequences. Therefore, in this paper, GHG assigned to iLUC is allocated between ethanol and human dietary preferences via a human nutrition-based method. Applying allocation approaches to iLUC lowers the estimated GHG of iLUC by up to 73% compared to GHG estimates in the GTAP model. For example, global warming intensity (GWI) of ethanol measured as CO2 equivalent becomes 58.2 g MJ−1, while GWI of ethanol calculated using GREET is 68.9 g MJ−1. -- Highlights: ► Biofuel production is one of many factors driving indirect land use change (iLUC). ► A proper allocation of the consequences of iLUC among these drivers is required. ► There are many choices in how we provide ourselves nutritionally adequate diets. ► Greenhouse gas emissions of iLUC are allocated via a human nutrition-based method.

  11. Single-stage repair of adult aortic coarctation and concomitant cardiovascular pathologies: a new alternative surgical approach

    Directory of Open Access Journals (Sweden)

    Saba Davit

    2006-06-01

    Full Text Available Abstract Background Coarctation of the aorta in the adulthood is sometimes associated with additional cardiovascular pathologies that require intervention. Ideal approach in such patients is uncertain. Anatomic left-sided short aortic bypass from the arcus aorta to descending aorta via median sternotomy allows simultaneuos repair of both complex aortic coarctation and concomitant cardiac operation. Materials Four adult patients were underwent Anatomic left-sided short aortic bypass operation for complex aortic coarctation through median sternotomy using deep hypothermic circulatory arrest. Concomitant cardiac operations were Bentall procedure for annuloaortic ectasia in one patient, coronary artery bypass grafting for three vessel disease in two patient, and patch closure of ventricular septal defect in one patient. Results All patients survived the operation and were alive with patent bypass at a mean follow-up of 36 months. No graft-related complications occurred, and there were no instances of stroke or paraplegia. Conclusion We conclude that single-stage repair of adult aortic coarctation with concomitant cardiovascular lesions can be performed safely using this newest technique.

  12. From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases

    Institute of Scientific and Technical Information of China (English)

    Antonin; Bukovsky

    2015-01-01

    Endogenous "stem cell niche"(SCN) accompanying vessels contains immune system components which in vivo determine differentiation of multi potent stem cells toward proper cell types in given tissue. Combinations of sex steroids may represent novel chemical approach for neuronal areas of regenerative medicine,since they cause transformation of vascular smooth muscle stem cells into differentiating neuronal cells. Circulating sex steroids are present during pregnancy and can be utilized where needed,when various embryonic/fetal tissues develop from their stem cells. Utilization of induced regeneration of tissues(regenerative medicine) is expected being more effective in sudden failures of younger individuals carrying intact SCN,as compared to established chronic disorders caused by SCN alteration. An essential component of SCN are monocyte-derived cells exhibiting tissue-specific "stop effect"(SE) preventing,for instance,an aging of neuronal cells. Its alteration causes that implantation of neuronal stem cells will also result in their differentiation toward aging cells. When we repair the SE by supply of circulating mononuclear cells from young healthy individuals,we may be able to provide novel regenerative treatments of age-induced neural diseases by sex steroid combinations. Questions regarding some age-induced body alterations are also addressed.

  13. The good practice of the police: an alternative approach in dealing with offenders who abuse/misuse alcohol.

    Science.gov (United States)

    Saunders, P

    1998-01-01

    The office of constable is taken by declaration and specifically says '... prevent all offences against the persons and properties ...'. The police service, like many hospitals and particularly casualty units, comes into initial contact with a high proportion of society's problems, including those related to people who cannot handle alcohol. This results directly or indirectly in a significant number of issues affecting social life detrimentally and at a tremendous cost to the public purse. These points at some time or another have been adequately illustrated by articles or television documentaries. The police service has a duty to prevent crime. The author maintains that, through the collaboration of the criminal justice agencies and health services, and using a simple approach, behaviour could be altered significantly enough to contribute towards a reduction in repeat offending and a consequent decline in the use of public funds. The author believes that a great number of people, too large to even contemplate quantifying, would have a better quality of life, a goal sought by many, and that the police service is well placed to participate constructively in the rehabilitation of offenders who have a 'drink' problem. PMID:9539180

  14. Application of the Price-Volume Approach in Cases of Innovative Drugs Where Value-Based Pricing is Inadequate: Description of Real Experiences in Italy.

    Science.gov (United States)

    Messori, Andrea

    2016-08-01

    Several cases of expensive drugs designed for large patient populations (e.g. sofosbuvir) have raised a complex question in terms of drug pricing. Even assuming value-based pricing, the treatment with these drugs of all eligible patients would have an immense budgetary impact, which is unsustainable also for the richest countries. This raises the need to reduce the prices of these agents in comparison with those suggested by the value-based approach and to devise new pricing methods that can achieve this goal. The present study discusses in detail the following two methods: (i) The approach based on setting nation-wide budget thresholds for individual innovative agents in which a fixed proportion of the historical pharmaceutical expenditure represents the maximum budget attributable to an innovative treatment; (ii) The approach based on nation-wide price-volume agreements in which drug prices are progressively reduced as more patients receive the treatment. The first approach has been developed in the USA by the Institute for Clinical and Economic Review and has been applied to PCSK9 inhibitors (alirocumab and evolocumab). The second approach has been designed for the Italian market and has found a systematic application to manage the price of ranibizumab, sofosbuvir, and PCSK9 inhibitors. While, in the past, price-volume agreements have been applied only on an empirical basis (i.e. in the absence of any quantitative theoretical rule), more recently some explicit mathematical models have been described. The performance of these models is now being evaluated on the basis of the real-world experiences conducted in some European countries, especially Italy. PMID:27216427

  15. Social impact evaluation : Some implications of the specific decisional context approach for anticipatory project assessment with special reference to available alternatives and to techniques of evaluating the social impacts of the anticipated effects of such alternatives

    Science.gov (United States)

    Mayo, L. H.

    1972-01-01

    The implications are explored of the specific decision context approach to anticipatory project assessment. More specifically, it is hypothesized that with respect to any given effect of a proposed project or action (mobility, job opportunities, air pollution, population distribution, etc.) such effect will likely differ in probability and/or magnitude from one decisional context to another; that the social desirability or undesirability of a given effect is a function (will differ with) each specific decisional context; that therefore the social impact of such effect will in all likelihood differ with each specific decisional context; and that the social significance of even the dame social impact of a given effect will vary from one decisional context to another when such social impact interacts with (competes with or reinforces) the social impacts of other effects. It also follows from this analysis that the respective roles of scientific method (demonstrable data) and adversarial system will not only differ with each specific decisional context but with each alternative course of action available to the decisional entity in each specific context.

  16. Coupled numerical approach combining finite volume and lattice Boltzmann methods for multi-scale multi-physicochemical processes

    International Nuclear Information System (INIS)

    A coupled (hybrid) simulation strategy spatially combining the finite volume method (FVM) and the lattice Boltzmann method (LBM), called CFVLBM, is developed to simulate coupled multi-scale multi-physicochemical processes. In the CFVLBM, computational domain of multi-scale problems is divided into two sub-domains, i.e., an open, free fluid region and a region filled with porous materials. The FVM and LBM are used for these two regions, respectively, with information exchanged at the interface between the two sub-domains. A general reconstruction operator (RO) is proposed to derive the distribution functions in the LBM from the corresponding macro scalar, the governing equation of which obeys the convection–diffusion equation. The CFVLBM and the RO are validated in several typical physicochemical problems and then are applied to simulate complex multi-scale coupled fluid flow, heat transfer, mass transport, and chemical reaction in a wall-coated micro reactor. The maximum ratio of the grid size between the FVM and LBM regions is explored and discussed. -- Highlights: •A coupled simulation strategy for simulating multi-scale phenomena is developed. •Finite volume method and lattice Boltzmann method are coupled. •A reconstruction operator is derived to transfer information at the sub-domains interface. •Coupled multi-scale multiple physicochemical processes in micro reactor are simulated. •Techniques to save computational resources and improve the efficiency are discussed

  17. Observational Study Designs for Comparative Effectiveness Research: An Alternative Approach to Close Evidence Gaps in Head-and-Neck Cancer

    International Nuclear Information System (INIS)

    Comparative effectiveness research (CER) has emerged as an approach to improve quality of care and patient outcomes while reducing healthcare costs by providing evidence to guide healthcare decisions. Randomized controlled trials (RCTs) have represented the ideal study design to support treatment decisions in head-and-neck (H and N) cancers. In RCTs, formal chance (randomization) determines treatment allocation, which prevents selection bias from distorting the measure of treatment effects. Despite this advantage, only a minority of patients qualify for inclusion in H and N RCTs, which limits the validity of their results to the broader H and N cancer patient population seen in clinical practice. Randomized controlled trials often do not address other knowledge gaps in the management of H and N cancer, including treatment comparisons for rare types of H and N cancers, monitoring of rare or late toxicity events (eg, osteoradionecrosis), or in some instances an RCT is simply not feasible. Observational studies, or studies in which treatment allocation occurs independently of investigators' choice or randomization, may address several of these gaps in knowledge, thereby complementing the role of RCTs. This critical review discusses how observational CER studies complement RCTs in generating the evidence to inform healthcare decisions and improve the quality of care and outcomes of H and N cancer patients. Review topics include a balanced discussion about the strengths and limitations of both RCT and observational CER study designs; a brief description of design and analytic techniques to handle selection bias in observational studies; examples of observational studies that inform current clinical practices and management of H and N cancers; and suggestions for relevant CER questions that could be addressed by an observational study design

  18. A novel geotechnical/geostatistical approach for exploration and production of natural gas from multiple geologic strata, Phase 1. Volume 1, Overview

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Reeves, T.K.; Salamy, S.P.; Locke, C.D.; Johnson, H.R.; Brunk, R.; Hawkins, L. [BDM Engineering Services Co., Morgantown, WV (United States)

    1991-05-01

    This research program has been designed to develop and verify a unique geostatistical approach for finding natural gas resources. The research has been conducted by Beckley College, Inc. (Beckley) and BDM Engineering Services Company (BDMESC) under contract to the US Department of Energy (DOE), Morgantown Energy Technology Center. Phase 1 of the project consisted of compiling and analyzing relevant geological and gas production information in selected areas of Raleigh County, West Virginia, ultimately narrowed to the Eccles, West Virginia, 7 {1/2} minute Quadrangle. The Phase 1 analysis identified key parameters contributing to the accumulation and production of natural gas in Raleigh County, developed analog models relating geological factors to gas production, and identified specific sites to test and verify the analysis methodologies by drilling. Based on the Phase 1 analysis, five sites have been identified with high potential for economic gas production. Phase 2 will consist of drilling, completing, and producing one or more wells at the sites identified in the Phase 1 analyses. The initial well is schedules to the drilled in April 1991. This report summarizes the results of the Phase 1 investigations. For clarity, the report has been prepared in two volumes. Volume 1 presents the Phase 1 overview; Volume 2 contains the detailed geological and production information collected and analyzed for this study.

  19. Using the Small Ruminant Nutrition System to develop and evaluate an alternative approach to estimating the dry matter intake of goats when accounting for ruminal fiber stratification.

    Science.gov (United States)

    Regadas Filho, J G L; Tedeschi, L O; Cannas, A; Vieira, R A M; Rodrigues, M T

    2014-11-01

    The first objective of this research was to assess the ability of the Small Ruminant Nutrition System (SRNS) mechanistic model to predict metabolizable energy intake (MEI) and milk yield (MY) when using a heterogeneous fiber pool scenario (GnG1), compared with a traditional, homogeneous scenario (G1). The second objective was to evaluate an alternative approach to estimating the dry matter intake (DMI) of goats to be used in the SRNS model. The GnG1 scenario considers an age-dependent fractional transference rate for fiber particles from the first ruminal fiber pool (raft) to an escapable pool (λr), and that this second ruminal fiber pool (i.e., escapable pool) follows an age-independent fractional escape rate for fiber particles (ke). Scenario G1 adopted only a single fractional passage rate (kp). All parameters were estimated individually by using equations published in the literature, except for 2 passage rate equations in the G1 scenario: 1 developed with sheep data (G1-S) and another developed with goat data (G1-G). The alternative approach to estimating DMI was based on an optimization process using a series of dietary constraints. The DMI, MEI, and MY estimated for the GnG1 and G1 scenarios were compared with the results of an independent dataset (n=327) that contained information regarding DMI, MEI, MY, and milk and dietary compositions. The evaluation of the scenarios was performed using the coefficient of determination (R(2)) between the observed and predicted values, mean bias (MB), bias correction factor (Cb), and concordance correlation coefficient. The MEI estimated by the GnG1 scenario yielded precise and accurate values (R(2) = 082; MB = 0.21 Mcal/d; Cb = 0.98) similar to those of the G1-S (R(2) = 0.85; MB = 0.10 Mcal/d; Cb=0.99) and G1-G (R(2) = 0.84; MB = 0.18 Mcal/d; Cb = 0.98) scenarios. The results were also similar for the MY, but a substantial MB was found as follows: GnG1 (R(2) = 0.74; MB = 0.70 kg/d; Cb = 0.79), G1-S (R(2) = 0.71; MB = 0

  20. A new MODIS based approach for gas flared volumes estimation: the case of the Val d'Agri Oil Center (Southern Italy)

    Science.gov (United States)

    Lacava, T.; Faruolo, M.; Coviello, I.; Filizzola, C.; Pergola, N.; Tramutoli, V.

    2014-12-01

    Gas flaring is one of the most controversial energetic and environmental issues the Earth is facing, moreover contributing to the global warming and climate change. According to the World Bank, each year about 150 Billion Cubic Meter of gas are being flared globally, that is equivalent to the annual gas use of Italy and France combined. Besides, about 400 million tons of CO2 (representing about 1.2% of global CO2 emissions) are added annually into the atmosphere. Efforts to evaluate the impact of flaring on the surrounding environment are hampered by lack of official information on flare locations and volumes. Suitable satellite based techniques could offers a potential solution to this problem through the detection and subsequent mapping of flare locations as well as gas emissions estimation. In this paper a new methodological approach, based on the Robust Satellite Techniques (RST), a multi-temporal scheme of satellite data analysis, was developed to analyze and characterize the flaring activity of the largest Italian gas and oil pre-treatment plant (ENI-COVA) located in Val d'Agri (Basilicata) For this site, located in an anthropized area characterized by a large environmental complexity, flaring emissions are mainly related to emergency conditions (i.e. waste flaring), being the industrial process regulated by strict regional laws. With reference to the peculiar characteristics of COVA flaring, the RST approach was implemented on 13 years of EOS-MODIS (Earth Observing System - Moderate Resolution Imaging Spectroradiometer) infrared data to detect COVA-related thermal anomalies and to develop a regression model for gas flared volume estimation. The methodological approach, the whole processing chain and the preliminarily achieved results will be shown and discussed in this paper. In addition, the possible implementation of the proposed approach on the data acquired by the SUOMI NPP - VIIRS (National Polar-orbiting Partnership - Visible Infrared Imaging

  1. Curriculum Assessment Using Artificial Neural Network and Support Vector Machine Modeling Approaches: A Case Study. IR Applications. Volume 29

    Science.gov (United States)

    Chen, Chau-Kuang

    2010-01-01

    Artificial Neural Network (ANN) and Support Vector Machine (SVM) approaches have been on the cutting edge of science and technology for pattern recognition and data classification. In the ANN model, classification accuracy can be achieved by using the feed-forward of inputs, back-propagation of errors, and the adjustment of connection weights. In…

  2. Wisconsin Inventor & Entrepreneur Clubs: Investment in an Innovative Approach to Entrepreneurship. Rural Research Report. Volume 20, Issue 1, Winter 2009

    Science.gov (United States)

    Wise, Greg

    2009-01-01

    Research on entrepreneurship in rural areas has increasingly stressed the importance of a supportive environment and social networks in enhancing innovation. This report examines a novel approach to promoting entrepreneurship using regional Inventor & Entrepreneur (I&E) Clubs. A telephone survey of 21 I&E Clubs was completed to collect information…

  3. A charge-conservative approach for simulating electrohydrodynamic two-phase flows using volume-of-fluid

    Science.gov (United States)

    López-Herrera, J. M.; Popinet, S.; Herrada, M. A.

    2011-03-01

    In the present study we propose a charge-conservative scheme to solve two-phase electrohydrodynamic (EHD) problems using the volume-of-fluid (VOF) method. EHD problems are usually simplified by assuming that the fluids involved are purely dielectric (insulators) or purely conducting. Gases can be considered as perfect insulators but pure dielectric liquids do not exist in nature and insulating liquids have to be approximated using the "Taylor-Melcher leaky dielectric model" [1,2] in which a leakage of charge through the liquid due to ohmic conduction is allowed. It is also a customary assumption to neglect the convection of charge against the ohmic conduction. The scheme proposed in this article can deal with any EHD problem since it does not rely on any of the above simplifications. An unrestricted EHD solver requires not only to incorporate electric forces in the Navier-Stokes equations, but also to consider the charge migration due to both conduction and convection in the electric charge conservation equation [3]. The conducting or insulating nature of the fluids arise on their own as a result of their electric and fluid mechanical properties. The EHD solver has been built as an extension to Gerris, a free software solver for the solution of incompressible fluid motion using an adaptive VOF method on octree meshes developed by Popinet [4,5].

  4. A volume-preserving sharpening approach for the propagation of sharp phase boundaries in multiphase lattice Boltzmann simulations

    KAUST Repository

    Reis, T.

    2011-07-01

    Lattice Boltzmann models that recover a macroscopic description of multiphase flow of immiscible liquids typically represent the boundaries between phases using a scalar function, the phase field, that varies smoothly over several grid points. Attempts to tune the model parameters to minimise the widths of these interfaces typically lead to the interfaces becoming fixed to the underlying grid instead of advecting with the fluid velocity. This phenomenon, known as lattice pinning, is strikingly similar to that associated with the numerical simulation of conservation laws coupled to stiff algebraic source terms. We present a lattice Boltzmann formulation of the model problem proposed by LeVeque and Yee (1990) [3] to study the latter phenomenon in the context of computational combustion, and offer a volume-conserving extension in multiple space dimensions. Inspired by the random projection method of Bao and Jin (2000) [1] we further generalise this formulation by introducing a uniformly distributed quasi-random variable into the term responsible for the sharpening of phase boundaries. This method is mass conserving, gives correct average propagation speeds over many timesteps, and is shown to significantly delay the onset of pinning as the interface width is reduced. © 2010 Elsevier Ltd.

  5. Argonne National Laboratory Expedited Site Characterization: First International Symposium on Integrated Technical Approaches to Site Characterization - Proceedings Volume

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-08

    Laboratory applications for the analysis of PCBS (polychlorinated biphenyls) in environmental matrices such as soil/sediment/sludge and oil/waste oil were evaluated for potential reduction in waste, source reduction, and alternative techniques for final determination. As a consequence, new procedures were studied for solvent substitution, miniaturization of extraction and cleanups, minimization of reagent consumption, reduction of cost per analysis, and reduction of time. These new procedures provide adequate data that meet all the performance requirements for the determination of PCBS. Use of the new procedures reduced costs for all sample preparation techniques. Time and cost were also reduced by combining the new sample preparation procedures with the power of fast gas chromatography. Separation of Aroclor 1254 was achieved in less than 6 min by using DB-1 and SPB-608 columns. With the greatly shortened run times, reproducibility can be tested quickly and consequently with low cost. With performance-based methodology, the applications presented here can be applied now, without waiting for regulatory approval.

  6. Argonne National Laboratory Expedited Site Characterization: First International Symposium on Integrated Technical Approaches to Site Characterization - Proceedings Volume

    International Nuclear Information System (INIS)

    Laboratory applications for the analysis of PCBS (polychlorinated biphenyls) in environmental matrices such as soil/sediment/sludge and oil/waste oil were evaluated for potential reduction in waste, source reduction, and alternative techniques for final determination. As a consequence, new procedures were studied for solvent substitution, miniaturization of extraction and cleanups, minimization of reagent consumption, reduction of cost per analysis, and reduction of time. These new procedures provide adequate data that meet all the performance requirements for the determination of PCBS. Use of the new procedures reduced costs for all sample preparation techniques. Time and cost were also reduced by combining the new sample preparation procedures with the power of fast gas chromatography. Separation of Aroclor 1254 was achieved in less than 6 min by using DB-1 and SPB-608 columns. With the greatly shortened run times, reproducibility can be tested quickly and consequently with low cost. With performance-based methodology, the applications presented here can be applied now, without waiting for regulatory approval

  7. Bounding approaches to system identification

    CERN Document Server

    Norton, John; Piet-Lahanier, Hélène; Walter, Éric

    1996-01-01

    In response to the growing interest in bounding error approaches, the editors of this volume offer the first collection of papers to describe advances in techniques and applications of bounding of the parameters, or state variables, of uncertain dynamical systems. Contributors explore the application of the bounding approach as an alternative to the probabilistic analysis of such systems, relating its importance to robust control-system design.

  8. Seeking an Alternative Modality to the Management of Nigeria's Fertilizer Subsidy Scheme-An Empirical Approach to the Case Study of Ondo State (1976-1996

    Directory of Open Access Journals (Sweden)

    Victor O. Asekunowo

    2010-01-01

    Full Text Available Problem statement: The objective of Nigeria’s fertilizer subsidy scheme was to make inorganic fertilizers readily available to farmers at affordable prices in order to boost food production in the country. Shortly into the scheme, farmers complained that fertilizers were not received at the time of need and in sufficient quantities. Approach: Using Ondo State, Nigeria as a case study, to determine; inter alia, if the farmers’ complaints were founded and if so, to design alternative ways of administering the scheme such that the lofty goals for which it was established could be realized. Methodology: Primary data were collected from 596 farmers randomly selected from the state. Secondary data were collected from purposively selected NAFCON, AISC, ADP, FPDD (now FFD and a published book source. The primary data were analyzed with the use of descriptive statistics such as percentages and means. The secondary data were analyzed with the use of OLS and TLS regression methods. Results: The descriptive analyses showed that farmers in Ondo State did not receive their fertilizer supplies in sufficient quantities and at the time of need, despite the fact that supply surpassed adoption (demand for most years of the study period. The inferential analyses showed that a subsidy introduced into NAFCON and other producing firms’ production processes would engender increased output and induce fertilizer prices to fall in Ondo State. Conclusion: These results showed that farmers in Ondo State did not receive their fertilizer supplies at the time of need and in sufficient quantities due to leakages and diversion of the substance from the vast bureaucratic distribution channels. As an alternative, if subsidy was administered through the producing firms’ production processes, output of fertilizers would have increased making the market supply curve of fertilizers to shift to the right. This would have also caused the price of fertilizer to

  9. Proceedings of RIKEN BNL Research Center Workshop: The Approach to Equilibrium in Strongly Interacting Matter. Volume 118

    Energy Technology Data Exchange (ETDEWEB)

    Liao, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Venugopalan, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Berges, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blaizot, J. -P. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gelis, F. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-04-09

    The RIKEN BNL Research Center (RBRC) was established in April 1997 at Brookhaven National Laboratory*. It is funded by the ''Rikagaku Kenkyusho'' (RIKEN, The Institute of Physical and Chemical Research) of Japan and the U. S. Department of Energy’s Office of Science. The RBRC is dedicated to the study of strong interactions, including spin physics, lattice QCD, and RHIC physics through the nurturing of a new generation of young physicists. The RBRC has theory, lattice gauge computing and experimental components. It is presently exploring the possibility of an astrophysics component being added to the program. The purpose of this Workshop is to critically review the recent progress on the theory and phenomenology of early time dynamics in relativistic heavy ion collisions from RHIC to LHC energies, to examine the various approaches on thermalization and existing issues, and to formulate new research efforts for the future. Topics slated to be covered include Experimental evidence for equilibration/isotropization, comparison of various approaches, dependence on the initial conditions and couplings, and turbulent cascades and Bose-Einstein condensation.

  10. Morphologic Study of Superior Temporal Sulcus-Amygdaloid Body and Lateral Fissure-Amygdaloid Body Surgical Approach by Using Magnetic Resonance Imaging Volume Rendering.

    Science.gov (United States)

    Qu, Yuan; Ren, Bichen; Chang, Xiaoyu; Zhang, Jinnan; Li, Youqiong; Duan, Haobo; Cheng, Kailiang; Wang, Jincheng

    2016-01-01

    In this research, 83 patients were measured by magnetic resonance imaging volume rendering technique. The authors acquired the curve length of the superior temporal sulcus and the lateral fissure on the cerebral hemisphere, the shortest distance from the superior temporal sulcus and the lateral fissure to the center of amygdaloid body separately, the vertical diameter, the transversal diameter, and the anteroposterior diameter of the amygdaloid body and the 2 approach angles between the median sagittal plane and the shortest segment from the superior temporal sulcus to the center of amygdaloid body and the shortest segment from lateral fissure to the center of the amygdaloid body. At the same time, we preliminarily oriented the 2 points of the superior temporal sulcus and the lateral fissure, which are closest to the center of amygdaloid body, aimed at finding out the best entrance points of surgical approach through the superior temporal sulcus and the lateral fissure to the amygdaloid body and reducing the damage to the nerve fibers or blood vessels during the operation. The results indicate that the point at the front side 1/4 of the superior temporal sulcus may be the ideal surgical approach entrance point and the point at the front side 1/3 of the lateral fissure. There is no difference between 2 cerebral hemispheres (P < 0.05).

  11. Perfusion MRI (dynamic susceptibility contrast imaging) with different measurement approaches for the evaluation of blood flow and blood volume in human gliomas

    DEFF Research Database (Denmark)

    Thomsen, Henrik; Larsson, Elna-Marie; Steffensen, Elena

    2012-01-01

    technique arterial spin labelling (ASL) presently provides measurement only of cerebral blood flow (CBF), which has not been widely used in human brain tumor studies. Purpose: To assess if measurement of blood flow is comparable with measurement of blood volume in human biopsy-proven gliomas obtained by DSC......, and glioblastomas. Results: rCBF and rCBV measurements obtained with the maximum perfusion method were correlated when normalized to white matter (r ¼ 0.60) and to the cerebellum (r ¼ 0.49). Histogram analyses of rCBF and rCBV showed that mean and median values as well as skewness and peak position were correlated......-MRI using two different regions for normalization and two different measurement approaches. Material and Methods: Retrospective study of 61 patients with different types of gliomas examined with DSC perfusion MRI. Regions of interest (ROIs) were placed in tumor portions with maximum perfusion on rCBF and r...

  12. Human factors evaluation of remote afterloading brachytherapy: Human error and critical tasks in remote afterloading brachytherapy and approaches for improved system performance. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Callan, J.R.; Kelly, R.T.; Quinn, M.L. [Pacific Science and Engineering Group, San Diego, CA (United States)] [and others

    1995-05-01

    Remote Afterloading Brachytherapy (RAB) is a medical process used in the treatment of cancer. RAB uses a computer-controlled device to remotely insert and remove radioactive sources close to a target (or tumor) in the body. Some RAB problems affecting the radiation dose to the patient have been reported and attributed to human error. To determine the root cause of human error in the RAB system, a human factors team visited 23 RAB treatment sites in the US The team observed RAB treatment planning and delivery, interviewed RAB personnel, and performed walk-throughs, during which staff demonstrated the procedures and practices used in performing RAB tasks. Factors leading to human error in the RAB system were identified. The impact of those factors on the performance of RAB was then evaluated and prioritized in terms of safety significance. Finally, the project identified and evaluated alternative approaches for resolving the safety significant problems related to human error.

  13. Human factors evaluation of remote afterloading brachytherapy: Human error and critical tasks in remote afterloading brachytherapy and approaches for improved system performance. Volume 1

    International Nuclear Information System (INIS)

    Remote Afterloading Brachytherapy (RAB) is a medical process used in the treatment of cancer. RAB uses a computer-controlled device to remotely insert and remove radioactive sources close to a target (or tumor) in the body. Some RAB problems affecting the radiation dose to the patient have been reported and attributed to human error. To determine the root cause of human error in the RAB system, a human factors team visited 23 RAB treatment sites in the US The team observed RAB treatment planning and delivery, interviewed RAB personnel, and performed walk-throughs, during which staff demonstrated the procedures and practices used in performing RAB tasks. Factors leading to human error in the RAB system were identified. The impact of those factors on the performance of RAB was then evaluated and prioritized in terms of safety significance. Finally, the project identified and evaluated alternative approaches for resolving the safety significant problems related to human error

  14. A better approach to care of the dying. Catholic healthcare and the Catholic community can present an alternative to physician-assisted suicide.

    Science.gov (United States)

    Hamel, R

    1998-01-01

    To combat physician-assisted suicide, Catholic healthcare and the Catholic community cannot solely focus on mounting campaigns and formulating policies. They must also demonstrate an alternative way to approach death and care of the dying, taking a leadership role in improving end-of-life care. To accomplish this, Catholic healthcare must foster a culture that recognizes death as the inevitable outcome of human life and makes care for the dying as important as care for those who may get well. The ministry must acknowledge the limits of human life, human abilities, human ingenuity, and medical technology; and respect decisions to forgo life-sustaining therapies. In addition, physicians must address advance directives with patients before hospitalization and must be willing to offer hospice care as an option to dying patients and their families. More effective pain management must be devised. Catholic facilities must develop palliative care policies and commit to ongoing education to provide such care. It is essential that they pay attention to the environment in which patients die; identify the physical, psychosocial, and spiritual needs of family members; and use prayer and rituals in meaningful ways. With a clear focus on improving end-of-life care, Catholic healthcare--in partnership with other denominations--can eliminate some of the factors that can make physician-assisted suicide seem appealing to suffering people.

  15. The PAVE (peeling-assisted volume-enhancing) lift: A retrospective 6-year clinical analysis of a combined approach for facial rejuvenation.

    Science.gov (United States)

    Kaye, Kai Oliver; Schaller, Hans-Eberhard; Jaminet, Patrick; Gonser, Phillipp

    2016-08-01

    The peeling-assisted volume-enhancing (PAVE) lift is a single-stage approach that combines superficial musculoaponeurotic system (SMAS) plication techniques with fat grafting and different peeling agents. To evaluate the safety of this approach, we analyzed the records of 159 patients who underwent surgery between 2008 and 2014. The percentage of complications observed was not higher than values reported in the literature for each treatment entity: surgical facelift: n=3 haematomas (1.89 %), n=2; temporary apraxia of the mandibular branch (1.26%); fat transfer: minor asymmetry in n = 5 cases (3.14%); peeling: temporary hyperpigmentation in trichloroacetic acid (n = 5; 3.8%) and phenol peels (n = 4; 3.1%), permanent hypopigmentation (n = 6; 5.6%), formation of skin miliae persisting longer than 2 to 3 months (n = 5; 4.6%) and prolonged erythema (n = 3; 0.28%) in phenol peels. The single-stage use of chemical peels, autologous fat transfer, and surgical rhytidectomy was safe. PMID:27320171

  16. Generalized Partial Volume

    DEFF Research Database (Denmark)

    Darkner, Sune; Sporring, Jon

    2011-01-01

    Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV). Their theoret......Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV...

  17. MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain.

    Science.gov (United States)

    Christen, T; Pannetier, N A; Ni, W W; Qiu, D; Moseley, M E; Schuff, N; Zaharchuk, G

    2014-04-01

    In the present study, we describe a fingerprinting approach to analyze the time evolution of the MR signal and retrieve quantitative information about the microvascular network. We used a Gradient Echo Sampling of the Free Induction Decay and Spin Echo (GESFIDE) sequence and defined a fingerprint as the ratio of signals acquired pre- and post-injection of an iron-based contrast agent. We then simulated the same experiment with an advanced numerical tool that takes a virtual voxel containing blood vessels as input, then computes microscopic magnetic fields and water diffusion effects, and eventually derives the expected MR signal evolution. The parameter inputs of the simulations (cerebral blood volume [CBV], mean vessel radius [R], and blood oxygen saturation [SO2]) were varied to obtain a dictionary of all possible signal evolutions. The best fit between the observed fingerprint and the dictionary was then determined by using least square minimization. This approach was evaluated in 5 normal subjects and the results were compared to those obtained by using more conventional MR methods, steady-state contrast imaging for CBV and R and a global measure of oxygenation obtained from the superior sagittal sinus for SO2. The fingerprinting method enabled the creation of high-resolution parametric maps of the microvascular network showing expected contrast and fine details. Numerical values in gray matter (CBV=3.1±0.7%, R=12.6±2.4μm, SO2=59.5±4.7%) are consistent with literature reports and correlated with conventional MR approaches. SO2 values in white matter (53.0±4.0%) were slightly lower than expected. Numerous improvements can easily be made and the method should be useful to study brain pathologies. PMID:24321559

  18. A pilot evaluation on a stress management programme using a combined approach of cognitive behavioural therapy (CBT) and complementary and alternative medicine (CAM) for elementary school teachers.

    Science.gov (United States)

    Tsang, Hector W H; Cheung, W M; Chan, Alan H L; Fung, Kelvin M T; Leung, Ada Y; Au, Doreen W H

    2015-02-01

    The aim of this study is to explore the efficacy of implementing a stress management programme based on a combined approach using cognitive behavioural therapy and complementary and alternative medicine for elementary school teachers who experienced mild level of stress, anxiety and/or depressive symptoms in Hong Kong. A 12-h programme involving cognitive behavioural therapy, self-management, relaxation techniques (diaphragmatic breathing and progressive muscle relaxation), mindful exercises (qigong and yoga), aromatherapy and acupressure was conducted. A quasi-experimental design was used to compare the intervention groups (n = 47) with the wait-list control groups (n = 46). The primary outcome measures were depression, anxiety and stress. Results indicated that the intervention group had significant reduction in depression [(F = 3.93; degrees of freedom (df) = 2.90; p = 0.023)], anxiety (F = 3.37; df = 2.90; p = 0.039) and stress (F = 3.63; df = 2.89; p = 0.031) when compared with the control group. Participants in both groups demonstrated lowered level of salivary cortisol at the post-assessment. The pilot results provided preliminary support to the multi-component stress management programme in relieving affective symptoms of teachers. The programme may be considered as an initial strategy to empower teachers with the abilities to cope with their affective symptoms. Further evaluation using a better designed randomized study with a larger sample size is warranted. (word: 198; max.: 200). PMID:24038798

  19. Alternative Treatments

    Science.gov (United States)

    ... Find your chapter: search by state Home > Alzheimer's Disease > Treatments > Alternative Treatments Overview What Is Dementia? What Is Alzheimer's? Younger/Early Onset Facts and Figures Know the 10 Signs Stages Inside the Brain: ...

  20. A Controls-CFD Approach for Estimation of Concentration from a Moving Aerial Source: Advantages of a Finite Volume-TVD implementation with Guidance-Based Grid Adaptation

    Science.gov (United States)

    Egorova, Tatiana; Gatsonis, Nikolaos A.; Demetriou, Michael A.

    2013-11-01

    In this work the process of gas release into the atmosphere by a moving aerial source is simulated and estimated using a sensing aerial vehicle (SAV). The process is modeled with atmospheric advection diffusion equation, which is solved by the finite volume method (FVM). Advective fluxes are constrained using total variation diminishing (TVD) approach. The estimator provides on-line estimates of concentration field and proximity of the source. The guidance of the SAV is dictated by the performance of the estimator. To further improve the estimation algorithm from the computational prospective, the grid is adapted dynamically through local refinement and coarsening. The adaptation algorithm uses the current sensor position as a center of refinement, with the areas further away from the SAV being covered by a coarse grid. This leads to the time varying state matrix of the estimator and the variation depends on the SAV motion. Advantages of the adaptive FVM-TVD implementation are illustrated on the examples of estimator performance for different source trajectories.