The U.S. RERTR Program. Status and progress

International Nuclear Information System (INIS)

Travelli, A.

1997-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

Army AL&T, July-September 2008

Science.gov (United States)

2008-09-01

Northern Region — Wanda Reed (PCO), Joann Langston (PARC), Debbie Emerson (Alt. to PARC) Southern Region — Julie Silva (PCO), Carol Lowman (Direc- tor/PARC...Charles Jaber (PCO), Roger Engebretson, (Director/PARC), Sharon Oishi (Alt. to PARC) U.S. Army Contracting Command, Southwest Asia — Carol Estes (PCO...Robyn Villafranco, Margarita Ramirez, Diana Fernandez, Donna Reed, Michely Walton, Elisa Mendez , Cynariah Wilkins, Deinor Bolanos, Belinda Kent

Association of ALT and the metabolic syndrome among Mexican children.

Science.gov (United States)

Elizondo-Montemayor, Leticia; Ugalde-Casas, Patricia A; Lam-Franco, Lorena; Bustamante-Careaga, Humberto; Serrano-González, Mónica; Gutiérrez, Norma G; Martínez, Ubaldo

2014-01-01

Nonalcoholic fatty liver disease (NAFLD) is emerging as a component of the metabolic syndrome (MetS); Hispanics being particularly predisposed. Alanine aminotransferase (ALT) is considered a marker of NAFLD. The aim of this study was to determine the prevalence and associations between ALT elevations and MetS in normal-weight, overweight and obese Mexican children and adolescents, since data in Mexico is scarce. Body mass index (BMI), waist circumference (WC), percentage body fat, blood pressure, glucose, lipid profiles, ALT and aspartate aminotransferase (AST) were measured in 236, 6-12yo normal-weight, overweight and obese Mexicans from eight public schools. The results showed that elevated ALT (>40 IU/L) was found in 17.7% of the obese and overweight population, with no gender difference. The prevalence of elevated ALT increased linearly across BMI categories (p = 0.001), from 0.0% for the normal-weight group (95%CI 0.0-€“8.0) to 22.4% for the obese one (95%CI 16.2-€“30.2). AST/ALT ratio obese one. The prevalence of MetS was strongly associated with elevated ALT (p = 0.002), 50% in the elevated ALT group (95%CI 34.1-€“65.9) and 24.1% in the normal ALT one (95%CI 18.1-€“31.3). There was also a strong association between MetS and an AST/ALT ratio obese children. © 2014 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

Near-Term Electric Vehicle Program. Phase II: Mid-Term Summary Report.

Energy Technology Data Exchange (ETDEWEB)

None

1978-08-01

The Near Term Electric Vehicle (NTEV) Program is a constituent elements of the overall national Electric and Hybrid Vehicle Program that is being implemented by the Department of Energy in accordance with the requirements of the Electric and Hybrid Vehicle Research, Development, and Demonstration Act of 1976. Phase II of the NTEV Program is focused on the detailed design and development, of complete electric integrated test vehicles that incorporate current and near-term technology, and meet specified DOE objectives. The activities described in this Mid-Term Summary Report are being carried out by two contractor teams. The prime contractors for these contractor teams are the General Electric Company and the Garrett Corporation. This report is divided into two discrete parts. Part 1 describes the progress of the General Electric team and Part 2 describes the progress of the Garrett team.

Status and progress of the RERTR program

International Nuclear Information System (INIS)

Travelli, A.

1996-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1996 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 1995 in collaboration with its many international partners. Significant progress has been made during the past year in each of the three areas that the delegates to last year's RERTR meeting chose to address, in their letter to President Clinton, as requiring special attention. (1) In the area of U.S. acceptance of spent fuel from foreign research reactors, a second shipment of 99 urgent-relief spent fuel elements was completed. The Final Environmental Impact Statement was published in February 1996, and the Record of Decision was published in May 1996. The first shipments under the Record of Decision, containing 280 spent fuel elements, were received at the Savannah River Site in September 1996. (2) In the area of advanced fuel development, adequate funding and guidance were received by the RERTR program in March 1996. Fuel development activities are now in progress, including procurement of equipment, screening of candidate materials, and preparations for the production of a first series of microplates. The first irradiations are planned to begin in the Advanced Test Reactor. in Idaho, during April 1997. (3) In the area of conversion of DOE research reactors, the RERTR program has been tasked by the Department of Energy to assess the feasibility of converting to LEU fuel each of the DOE research reactors which currently use HEU fuel. A preliminary assessment will be presented at this meeting. Significant progress has been made by the Russian RERTR program, which aims to develop and demonstrate within the next five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with excellent results

Progress of the PEP-II B-factory

International Nuclear Information System (INIS)

Seeman, J.; Browne, M.; Cai, Y.; Colocho, W.; Decker, F.-J.; Donald, M.; Ecklund, S.; Erickson, R.; Fisher, A.; Fox, J.; Heifets, S.; Iverson, R.; Kozanecki, W.; Krejcik, P.; Kulikov, A.; Novokhatski, A.; Schuh, P.; Schwarz, H.; Stanek, M.; Sullivan, M.; Teytelman, D.; Turner, J.; Wienands, U.; Yan, Y.; Yocky, J.; Biagini, M.; Zisman, M.

2003-01-01

PEP-II is an e + e - B-Factory Collider located at SLAC operating at the Upsilon 4S resonance. PEP-II has delivered, over the past five years, an integrated luminosity to the BaBar detector of over 139 fb -1 and has reached a luminosity of 6.58 x 10 36 /cm 2 /s. Steady progress is being made in reaching higher luminosity. The goal over the next several years is to reach a luminosity of at least 2 x 10 34 /cm 2 /s. The accelerator physics issues being addressed in PEP-II to reach this goal include the electron cloud instability, beam-beam effects, parasitic beam-beam effects, high RF beam loading, shorter bunches, lower beta y*, interaction region operation, and coupling control. A view of the PEP-II tunnel is shown in Figure 1. The present parameters of the PEP-II B-Factory are shown in Table 1 compared to the design. The present peak luminosity is 219% of design and the best integrated luminosity per month is 7.4 fb -1 that is 225% of design. The best luminosity per month is shown in Figure 2. The integrated luminosity over a month is shown in Figure 3 and the total integrated luminosity in shown in Figure 4. The progress in luminosity has come from correcting the orbits, adding specific orbit bumps to correct coupling and dispersion issues, lowering the beta y* in the LER, and moving the fractional horizontal tunes in both rings to just above the half integer (<0.52)

Alternative Liquid Fuels Simulation Model (AltSim).

Energy Technology Data Exchange (ETDEWEB)

Williams, Ryan; Baker, Arnold Barry; Drennen, Thomas E.

2009-12-01

The Alternative Liquid Fuels Simulation Model (AltSim) is a high-level dynamic simulation model which calculates and compares the production and end use costs, greenhouse gas emissions, and energy balances of several alternative liquid transportation fuels. These fuels include: corn ethanol, cellulosic ethanol from various feedstocks (switchgrass, corn stover, forest residue, and farmed trees), biodiesel, and diesels derived from natural gas (gas to liquid, or GTL), coal (coal to liquid, or CTL), and coal with biomass (CBTL). AltSim allows for comprehensive sensitivity analyses on capital costs, operation and maintenance costs, renewable and fossil fuel feedstock costs, feedstock conversion ratio, financial assumptions, tax credits, CO{sub 2} taxes, and plant capacity factor. This paper summarizes the structure and methodology of AltSim, presents results, and provides a detailed sensitivity analysis. The Energy Independence and Security Act (EISA) of 2007 sets a goal for the increased use of biofuels in the U.S., ultimately reaching 36 billion gallons by 2022. AltSim's base case assumes EPA projected feedstock costs in 2022 (EPA, 2009). For the base case assumptions, AltSim estimates per gallon production costs for the five ethanol feedstocks (corn, switchgrass, corn stover, forest residue, and farmed trees) of $1.86, $2.32, $2.45, $1.52, and $1.91, respectively. The projected production cost of biodiesel is $1.81/gallon. The estimates for CTL without biomass range from $1.36 to $2.22. With biomass, the estimated costs increase, ranging from $2.19 per gallon for the CTL option with 8% biomass to $2.79 per gallon for the CTL option with 30% biomass and carbon capture and sequestration. AltSim compares the greenhouse gas emissions (GHG) associated with both the production and consumption of the various fuels. EISA allows fuels emitting 20% less greenhouse gases (GHG) than conventional gasoline and diesels to qualify as renewable fuels. This allows several of the

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

DEFF Research Database (Denmark)

Lafferty-Whyte, K; Cairney, C J; Will, M B

2009-01-01

Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is made at the cellular le......TERT in different tumour types and normal tissues. We also show evidence to suggest a novel mesenchymal stem cell origin for ALT immortalization in cell lines and mesenchymal tissues....

The major Alternaria alternata allergen, Alt a 1: A reliable and specific marker of fungal contamination in citrus fruits.

Science.gov (United States)

Gabriel, M F; Uriel, N; Teifoori, F; Postigo, I; Suñén, E; Martínez, J

2017-09-18

The ubiquitously present spores of Alternaria alternata can spoil a wide variety of foodstuffs, including a variety of fruits belonging to the Citrus genus. The major allergenic protein of A. alternata, Alt a 1, is a species-specific molecular marker that has been strongly associated with allergenicity and phytopathogenicity of this fungal species. This study aimed to evaluate the potential of the detection of Alt a 1 as a reliable indicator of A. alternata contamination in citrus fruits. To accomplish this aim, sixty oranges were artificially infected with a spore suspension of A. alternata. Internal fruit material was collected at different incubation times (one, two and three weeks after the fungal inoculation) and used for both total RNA extraction and protein extraction. Alt a 1 detection was then performed by polymerase chain reaction (PCR) amplification using Alt a 1 specific primers and by enzyme-linked immunosorbent assay (ELISA). The experimental model presented in this work was effective to simulate the typical Alternaria black rot phenotype and its progression. Although both PCR and ELISA techniques have been successfully carried out for detecting Alt a 1 allergen in A. alternata infected oranges, the PCR method was found to be more sensitive than ELISA. Nevertheless, ELISA results were highly valuable to demonstrate that considerable amounts of Alt a 1 are produced during A. alternata fruit infection process, corroborating the recently proposed hypothesis that this protein plays a role in the pathogenicity and virulence of Alternaria species. Such evidence suggests that the detection of Alt a 1 by PCR-based assay may be used as a specific indicator of the presence of pathogenic and allergenic fungal species, A. alternata, in fruits. This knowledge can be employed to control the fungal infection and mitigate agricultural losses as well as human exposure to A. alternata allergens and toxins. Copyright © 2017 Elsevier B.V. All rights reserved.

21 CFR 862.1030 - Alanine amino transferase (ALT/SGPT) test system.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Alanine amino transferase (ALT/SGPT) test system... Test Systems § 862.1030 Alanine amino transferase (ALT/SGPT) test system. (a) Identification. An alanine amino transferase (ALT/SGPT) test system is a device intended to measure the activity of the...

High energy physics studies. Progress report. Part I. Experimental program. Part II. Theoretical program

International Nuclear Information System (INIS)

Romanowski, T.A.; Tanaka, K.; Wada, W.W.

1978-01-01

Experimental Program: assembly of an experiment as Fermilab E-531 to measure decay lifetimes, with tagged emulsion of charmed particles produced by high energy neutrinos was finished, and data taking now is in progress. An experiment to measure prompt neutrino production at Fermilab, E-613, was approved and detailed design of it is continuing. Search for parity violation in scattering of polarized protons, an experiment E-446-ZGS at ANL, was performed with the sensitivity of 10 -6 for detection of that process and yielded null results. Another run with improved sensitivity of 10 -7 is in preparation. Data analysis of the neutrino experiment E-310 at Fermilab will continue. Trimuon events, a new discovery, were identified in those data. Analysis of data on meson production from experiments performed at the ZGS--ANL, E-397, E-420 and E-428, with charged and neutral spectrometer will continue. A new relatively broad resonance (T approx. 70 MeV) with quantum numbers IJ/sup P/ = 00 -1 was discovered in the data from E-397. Analysis of beta decay of polarized Σ - hyperons is in progress. Participation in the design of the experimental areas for the Isabelle colliding proton beam accelerator will continue. Theoretical Program: topics of current interest in particle theory which will be investigated in the coming year are: the instanton-anti-instanton QCD gauge fields, discrete symmetries which may determine quark masses in the SU(2) x U(1) model, calculation of charmed meson production in e + e - collisions and formation of gluon jets, Higgs boson production in pp collisions, calculation of Higgs boson mass in terms of vector boson mass, study of Lagrangians with gauge and Higgs scalar fields, investigation of Faddeev--Popov determinants as related to quantum chromodynamics, a study of quantum flavor dynamics and anomalies in the axial vector Ward identity and a study of super symmetry as a part of a realistic model of leptonic interactions

ELEVATED ALT AND AST IN AN ASYMPTOMATIC PERSON

Directory of Open Access Journals (Sweden)

KEW ST

2009-01-01

Full Text Available -Abnormal liver function test with raised alanine aminotransferase (ALT and raised aspartate aminotransferase (AST are commonly seen in primary care setting. -Chronic alcohol consumption, drugs, non-alcoholic steatohepatitis (NASH and chronic viral hepatitis are common causes associated with raised ALT and AST. -In chronic viral hepatitis, the elevation of liver enzyme may not correlate well with the degree of liver damage. -Non-hepatic causes of raised ALT and AST include polymyositis, acute muscles injury, acute myocardial infarction and hypothyroidism. -In the primary care setting, the doctor should obtain a complete history regarding the risk factors for viral hepatitis, substance abuse and request investigations accordingly. -Suspected chronic viral hepatitis and liver cirrhosis are best referred to hepatologist for further management.

The Glen Canyon Dam adaptive management program: progress and immediate challenges

Science.gov (United States)

Hamill, John F.; Melis, Theodore S.; Boon, Philip J.; Raven, Paul J.

2012-01-01

Adaptive management emerged as an important resource management strategy for major river systems in the United States (US) in the early 1990s. The Glen Canyon Dam Adaptive Management Program (‘the Program’) was formally established in 1997 to fulfill a statutory requirement in the 1992 Grand Canyon Protection Act (GCPA). The GCPA aimed to improve natural resource conditions in the Colorado River corridor in the Glen Canyon National Recreation Area and Grand Canyon National Park, Arizona that were affected by the Glen Canyon dam. The Program achieves this by using science and a variety of stakeholder perspectives to inform decisions about dam operations. Since the Program started the ecosystem is now much better understood and several biological and physical improvements have been achieved. These improvements include: (i) an estimated 50% increase in the adult population of endangered humpback chub (Gila cypha) between 2001 and 2008, following previous decline; (ii) a 90% decrease in non-native rainbow trout (Oncorhynchus mykiss), which are known to compete with and prey on native fish, as a result of removal experiments; and (iii) the widespread reappearance of sandbars in response to an experimental high-flow release of dam water in March 2008.Although substantial progress has been made, the Program faces several immediate challenges. These include: (i) defining specific, measurable objectives and desired future conditions for important natural, cultural and recreational attributes to inform science and management decisions; (ii) implementing structural and operational changes to improve collaboration among stakeholders; (iii) establishing a long-term experimental programme and management plan; and (iv) securing long-term funding for monitoring programmes to assess ecosystem and other responses to management actions. Addressing these challenges and building on recent progress will require strong and consistent leadership from the US Department of the Interior

The Transition between Telomerase and ALT Mechanisms in Hodgkin Lymphoma and Its Predictive Value in Clinical Outcomes

Directory of Open Access Journals (Sweden)

Radhia M’kacher

2018-05-01

Full Text Available Background: We analyzed telomere maintenance mechanisms (TMMs in lymph node samples from HL patients treated with standard therapy. The TMMs correlated with clinical outcomes of patients. Materials and Methods: Lymph node biopsies obtained from 38 HL patients and 24 patients with lymphadenitis were included in this study. Seven HL cell lines were used as in vitro models. Telomerase activity (TA was assessed by TRAP assay and verified through hTERT immunofluorescence expression; alternative telomere lengthening (ALT was also assessed, along with EBV status. Results: Both TA and ALT mechanisms were present in HL lymph nodes. Our findings were reproduced in HL cell lines. The highest levels of TA were expressed in CD30−/CD15− cells. Small cells were identified with ALT and TA. Hodgkin and Reed Sternberg cells contained high levels of PML bodies, but had very low hTERT expression. There was a significant correlation between overall survival (p < 10−3, event-free survival (p < 10−4, and freedom from progression (p < 10−3 and the presence of an ALT profile in lymph nodes of EBV+ patients. Conclusion: The presence of both types of TMMs in HL lymph nodes and in HL cell lines has not previously been reported. TMMs correlate with the treatment outcome of EBV+ HL patients.

The Studsvik power transient programs Demo-Ramp II and Trans-Ramp I

International Nuclear Information System (INIS)

Bergenlid, U.; Lysell, G.; Mogard, H.; Roennberg, G.

1984-01-01

The Studsvik Demo-Ramp II och Trans-Ramp I are internationally sponsored research programs. The main objectives are similar in both programs: to study the effects on the PCI/SCC failure process of short time power transients, above the failure threshold where cladding failure (FP leakage) is expected to occur after a sufficient hold time. Demo-Ramp II is completed, whereas, at present, Trans-Ramp I is in progress. Test fuel rods of standard BWR design are used. The fuel rods have been base-irradiated in a power reactor (burn-up in the range 18 to 29 MWd/kg U) and subsequently ramp tested in the R2 reactor. Extensive examinations of the rods have been performed. In the Demo-Ramp II program a large number of incipient cladding cracks were observed to be formed more rapidly than expected, based on previous knowledge. It was possible to operate one rod for a very short time above the failure threshold without SCC crack formation. One objective of the Trans-Ramp I program is to define more closely the power-time region above the failure threshold where the rods remain intact after power transients. (author)

LMFBR aerosol release and transport program. Quarterly progress report, July-September 1981

International Nuclear Information System (INIS)

Kress, T.S.; Tobias, M.L.

1982-01-01

This report summarizes progress for the Aerosol Release and Transport Program sponsored by the Office of Nuclear Regulatory Research, Division of Accident Evaluation of the Nuclear Regulatory Commission for the period July-September 1981. Topics discussed include (1) preparations for under-sodium tests at the Fast Aerosol Simulant Test Facility, (2) progress in interpretation of Oak Ridge National Laboratory-Sandia Laboratory normalization test results, (3) U 3 O 8 in steam (light-water reactor accident) aerosol experiments conducted in the Nuclear Safety Power Plant, (4) experiments on B 2 O 3 and SiO 2 aerosols at the Containment Research Installation-II Facility, (5) fuel-melting tests in small-scale experimental facilities for the core-melt aerosol program, (6) analytical comparison of simple adiabatic nonlinear and linear analytical models of bubble oscillation phenomena with experimental data

General Time-Division AltBOC Modulation Technique for GNSS Signals

Directory of Open Access Journals (Sweden)

Z. Zhou

2018-04-01

Full Text Available In this paper, a general time-division alternate binary offset carrier (GTD-AltBOC modulation method is proposed, which is an extension of TD-AltBOC and time-multiplexed offset-carrier quadrature phase shift keying (TMOC-QPSK with high design flexibility. In this method, binary complex subcarriers and a time-division technique with flexible time slot assignment are used to achieve constant envelope modulation of the signal components with a variable power allocation ratio (PAR. The underlying principle of GTD-AltBOC and the constraints related to the PAR are investigated. For the generation of GTD-AltBOC signals, a lookup table (LUT-based scheme is presented; the minimum required clock rate is half or less of that for existing non-time-division methods. The receiver processing complexities are analyzed for three typical receiving modes, and the power spectral densities (PSDs, cross-correlation functions, multiplexing efficiencies and code-tracking performance are simulated; the results show that GTD-AltBOC enables a significant decrease in receiving complexity compared with existing methods while maintaining high performance in terms of multiplexing efficiency and code tracking.

Solar lease grant program. Technical progress report

Energy Technology Data Exchange (ETDEWEB)

1981-04-01

Progress on a lease program for the installation of a solar water heater with no installation charge is reported. Information on the announcement of the program, the selection of participants, the contractural agreement, progress on installation of equipment, monitoring, and evaluation is summarized. The status of the budget concerned with the program is announced. Forms used for applications for the program and an announcement from Resource Alternatives for Cilco customers are presented.

Editorial ALT-J non-electronica

Directory of Open Access Journals (Sweden)

Gabriel Jacobs

1997-12-01

Full Text Available The ALT Executive Committee has discussed on a number of occasions the question of making ALT-J wholly available in electronic form on our Web site (at present only the editorial and abstracts of papers appear, and even of turning it into a full-blown electronic journal. I have gently but consistently opposed this move, on occasions to the intense irritation of some of my fellow members, and always at the risk of appearing to be a Luddite. Explicitly ('Who, if not we as learning technologists, should be in the forefront of the soon-to-happen electronic-journal revolution?' and implicitly ('It is estimated that within two years, paper-based journals will be considered the dinosaurs of the academic world', I have increasingly come under pressure to accede to an apparently unstoppable, apparently imminent change in the method and form of scholarly publication. I set out here my reasons for my continued resistance.

The RERTR program status and progress

International Nuclear Information System (INIS)

Travelli, A.

2004-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1995 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 994 in collaboration with its many international partners. The revelation that Iraq was on the verge of developing a nuclear weapon at the time of the Gulf War, and that it was planning to do so by extracting HEU from the fuel of its research reactors, has given new impetus and urgency to the RERTR commitment of eliminating HEU use in research and test reactors worldwide. The Draft Environmental Impact Statement on the DOE policy for managing spent nuclear fuels from foreign research reactors was published on schedule. A Record of Decision is due in December 1995. After much legal debate, a first shipment of 153 urgent-relief elements took place, and another 151 elements became eligible for shipment. Development of advanced LEU research reactor fuels is scheduled to begin in October 1995, after DOE funding is received. Funding for equipment needed to begin this activity was provided by the US Department of State, and procurement of the equipment is in progress. The Russian RERTR program, which aims to develop and demonstrate within the next five years the technical means needed to convert Russian-supplied research reactors to LEU fuels, is now in operation. A Statement of Intent was signed by high US and Chinese officials, endorsing cooperative activities between the RERTR program and Chinese laboratories involved in similar activities. Joint studies of LEU technical feasibility were completed for the SAFARI-1 reactor in South Africa and for the ANS reactor in the US. The ANS project was later canceled for budgetary and nonproliferation reasons. A new study has been initiated for the FRM-II reactor in Germany. Significant progress was made on several aspects of producing 99 Mo from fission targets utilizing LEU instead of

Quality Assurance Program Plan for TRUPACT-II Gas Generation Test Program

International Nuclear Information System (INIS)

2002-01-01

The Gas Generation Test Program (GGTP), referred to as the Program, is designed to establish the concentration of flammable gases and/or gas generation rates in a test category waste container intended for shipment in the Transuranic Package Transporter-II (TRUPACT-II). The phrase 'gas generationtesting' shall refer to any activity that establishes the flammable gas concentration or the flammable gas generation rate. This includes, but is not limited to, measurements performed directly on waste containers or during tests performed on waste containers. This Quality Assurance Program Plan (QAPP) documents the quality assurance (QA) and quality control (QC) requirements that apply to the Program. The TRUPACT-II requirements and technical bases for allowable flammable gas concentration and gas generation rates are described in the TRUPACT-II Authorized Methods for Payload Control (TRAMPAC).

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.

Science.gov (United States)

Mateos-Gomez, Pedro A; Kent, Tatiana; Deng, Sarah K; McDevitt, Shane; Kashkina, Ekaterina; Hoang, Trung M; Pomerantz, Richard T; Sfeir, Agnel

2017-12-01

Mammalian polymerase theta (Polθ) is a multifunctional enzyme that promotes error-prone DNA repair by alternative nonhomologous end joining (alt-NHEJ). Here we present structure-function analyses that reveal that, in addition to the polymerase domain, Polθ-helicase activity plays a central role during double-strand break (DSB) repair. Our results show that the helicase domain promotes chromosomal translocations by alt-NHEJ in mouse embryonic stem cells and also suppresses CRISPR-Cas9- mediated gene targeting by homologous recombination (HR). In vitro assays demonstrate that Polθ-helicase activity facilitates the removal of RPA from resected DSBs to allow their annealing and subsequent joining by alt-NHEJ. Consistent with an antagonistic role for RPA during alt-NHEJ, inhibition of RPA1 enhances end joining and suppresses recombination. Taken together, our results reveal that the balance between HR and alt-NHEJ is controlled by opposing activities of Polθ and RPA, providing further insight into the regulation of repair-pathway choice in mammalian cells.

Nondestructive Evaluation Program: Progress in 1986

International Nuclear Information System (INIS)

1987-07-01

The increasing cost of equipment for power generating plants and the potential increases in productivity and safety available through rapidly developing Nondestructive Evaluation (NDE) technology led EPRI to initiate a Nondestructive Evaluation Program in 1974. To date, the major focus has been on light water reactor inspection problems; however, increased application to other systems is now under way. This report presents a comprehensive review of the EPRI effort in the NDE area. Most of the report consists of contractor-supplied progress reports on each current project. An organizational plan of the program is presented in overview. In addition, organization from several viewpoints is presented, e.g., in-service inspection operators, R and D personnel, and utility representatives. The report summarizes significant progress made since the previous EPRI Special Report NP-4315-SR was issued in May 1986. Section 1 contains information about the program organization, and the sections that follow contain contractor-supplied progress reports of each current project. The progress reports are grouped by plant components - pipe, pressure vessel, steam generator and boiler tubes, and turbine. In addition, Part 6 is devoted to discussions of technology transfer

Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

Science.gov (United States)

Jeyapalan, Jennie N; Varley, Helen; Foxon, Jenny L; Pollock, Raphael E; Jeffreys, Alec J; Henson, Jeremy D; Reddel, Roger R; Royle, Nicola J

2005-07-01

Immortal human cells maintain telomere length by the expression of telomerase or through the alternative lengthening of telomeres (ALT). The ALT mechanism involves a recombination-like process that allows the rapid elongation of shortened telomeres. However, it is not known whether activation of the ALT pathway affects other sequences in the genome. To address this we have investigated, in ALT-expressing cell lines and tumours, the stability of tandem repeat sequences known to mutate via homologous recombination in the human germline. We have shown extraordinary somatic instability in the human minisatellite MS32 (D1S8) in ALT-expressing (ALT+) but not in normal or telomerase-expressing cell lines. The MS32 mutation frequency varied across 15 ALT+ cell lines and was on average 55-fold greater than in ALT- cell lines. The MS32 minisatellite was also highly unstable in three of eight ALT+ soft tissue sarcomas, indicating that somatic destabilization occurs in vivo. The MS32 mutation rates estimated for two ALT+ cell lines were similar to that seen in the germline. However, the internal structures of ALT and germline mutant alleles are very different, indicating differences in the underlying mutation mechanisms. Five other hypervariable minisatellites did not show elevated instability in ALT-expressing cell lines, indicating that minisatellite destabilization is not universal. The elevation of MS32 instability upon activation of the ALT pathway and telomere length maintenance suggests there is overlap between the underlying processes that may be tractable through analysis of the D1S8 locus.

Magnetic fusion energy materials technology program annual progress report for period ending June 30, 1977

International Nuclear Information System (INIS)

Scott, J.L.

1977-09-01

The objectives of the Magnetic Fusion Energy (MFE) Materials Technology Program, which is described in this report, are to continue to solve the materials problems of the Fusion Energy Division of ORNL and to meet needs of the national MFE program, directed by the ERDA Division of Magnetic Fusion Energy (DMFE). This work is a continuation of the program described in previous annual progress reports. The principal areas of work include radiation effects, compatibility studies, materials studies related to the plasma-materials interaction, materials engineering, radiation behavior of superconducting magnet insulation, and mechanical properties of superconducting composites. The level of effort and schedules are consistent with Logic II of the DMFE Program Plan

Production of the Allergenic Protein Alt a 1 by Alternaria Isolates from Working Environments

Directory of Open Access Journals (Sweden)

Justyna Skóra

2015-02-01

Full Text Available The aim of the study was to evaluate the ability of Alternaria isolates from workplaces to produce Alt a 1 allergenic protein, and to analyze whether technical materials (cellulose, compost, leather present within the working environment stimulate or inhibit Alt a 1 production (ELISA test. Studies included identification of the isolated molds by nucleotide sequences analyzing of the ITS1/ITS2 regions, actin, calmodulin and Alt a 1 genes. It has been shown that Alternaria molds are significant part of microbiocenosis in the archive, museum, library, composting plant and tannery (14%–16% frequency in the air. The presence of the gene encoding the Alt a 1 protein has been detected for the strains: Alternaria alternata, A. lini, A. limoniasperae A. nobilis and A. tenuissima. Environmental strains produced Alt a 1 at higher concentrations (1.103–6.528 ng/mL than a ATCC strain (0.551–0.975 ng/mL. It has been shown that the homogenization of the mycelium and the use of ultrafiltration allow a considerable increase of Alt a 1 concentration. Variations in the production of Alt a 1 protein, depend on the strain and extraction methods. These studies revealed no impact of the technical material from the workplaces on the production of Alt a 1 protein.

PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

International Nuclear Information System (INIS)

Thulin, Petra; Rafter, Ingalill; Stockling, Kenneth; Tomkiewicz, Celine; Norjavaara, Ensio; Aggerbeck, Martine; Hellmold, Heike; Ehrenborg, Ewa; Andersson, Ulf; Cotgreave, Ian; Glinghammar, Bjoern

2008-01-01

In this work, we investigated a potential mechanism behind the observation of increased aminotransferase levels in a phase I clinical trial using a lipid-lowering drug, the peroxisome proliferator-activated receptor (PPAR) α agonist, AZD4619. In healthy volunteers treated with AZD4619, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were elevated without an increase in other markers for liver injury. These increases in serum aminotransferases have previously been reported in some patients receiving another PPARα agonist, fenofibrate. In subsequent in vitro studies, we observed increased expression of ALT1 protein and mRNA in human hepatocytes after treatment with fenofibric acid. The PPAR effect on ALT1 expression was shown to act through a direct transcriptional mechanism involving at least one PPAR response element (PPRE) in the proximal ALT1 promoter, while no effect of fenofibrate and AZD4619 was observed on the ALT2 promoter. Binding of PPARs to the PPRE located at - 574 bp from the transcriptional start site was confirmed on both synthetic oligonucleotides and DNA in hepatocytes. These data show that intracellular ALT expression is regulated by PPAR agonists and that this mechanism might contribute to increased ALT activity in serum

Thermal load distribution on the ALT-II limiter of TEXTOR-94 during RI mode operation and during disruptions

International Nuclear Information System (INIS)

Finken, K.H.; Denner, T.; Mank, G.

2000-01-01

Thermographic measurements using an IR scanner have been performed at the pump limiter ALT-II of TEXTOR-94 during RI mode discharges and during disruptions. The measurements on the RI mode discharges were done to complete the TEXTOR database which had shown a structured decay pattern of the deposited power. It was found that the underlying radial heat flux can be described by two exponential decay functions. This structure, which generates an unexpected heat component close to the tangent line, has been observed in all discharge conditions including the RI mode. During disruptions, the heat is released in short pulses with a typical duration of 0.01-0.1 ms. The radial decay length of these pulses has a similar shape to the heat flux during normal discharges: it consists again of a strong component close to the tangent line with a radial decay length of 2-5 mm and probably one with a decay length of the order of 1 cm. The heat is released at the time when the edge electron temperature of the plasma drops, when intense hydrogen and carbon fluxes occur near the walls, and when electrical currents in the limiter blades are excited. In a tentative interpretation, the temporal and spatial structure of the heat pulse is attributed to the presence and growth of a laminar zone at the plasma edge, which is connected with the ergodization of the plasma edge during a disruption. (author)

Relationship between stage II transport and number of chewing strokes as mastication progresses.

Science.gov (United States)

Yamashita, Shuichiro; Sugita, Daisuke; Matsuo, Koichiro

2013-10-02

As mastication progresses, little is known about the occurrence of the stage II transport (oro-pharyngeal bolus transport). This study aimed to investigate the relationship between stage II transport and bolus aggregation in the pharynx and the number of chewing strokes. Twenty-five clinical residents with natural dentitions were recruited. The subjects were asked to chew gummy jelly with their preferred rhythm and to swallow the bolus at their preferred timing. To investigate stage II transport and bolus aggregation in the pharynx, a transnasal endoscope was used. The number of chewing strokes was measured by electromyographic activity from the masseter muscle. The mean numbers of chewing strokes of pre-stage II transport and post-stage II transport were 29.8 and 8.1, respectively; the difference was significant (pchewing strokes of pre-stage II transport to that of post-stage II transport was 4.0 to 1.0. This study showed that stage II transport started at four-fifths of the way along the progress of mastication, and that stage II transport and bolus aggregation in the pharynx are related to the number of chewing strokes. © 2013. Published by Elsevier Inc. All rights reserved.

The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells

Energy Technology Data Exchange (ETDEWEB)

Huang, Chenhui; Jia, Pingping; Chastain, Megan; Shiva, Olga; Chai, Weihang, E-mail: wchai@wsu.edu

2017-06-15

Maintaining functional telomeres is important for long-term proliferation of cells. About 15% of cancer cells are telomerase-negative and activate the alternative-lengthening of telomeres (ALT) pathway to maintain their telomeres. Recent studies have shown that the human CTC1/STN1/TEN1 complex (CST) plays a multi-faceted role in telomere maintenance in telomerase-expressing cancer cells. However, the role of CST in telomere maintenance in ALT cells is unclear. Here, we report that human CST forms a functional complex localizing in the ALT-associated PML bodies (APBs) in ALT cells throughout the cell cycle. Suppression of CST induces telomere instabilities including telomere fragility and elevates telomeric DNA recombination, leading to telomere dysfunction. In addition, CST deficiency significantly diminishes the abundance of extrachromosomal circular telomere DNA known as C-circles and t-circles. Suppression of CST also results in multinucleation in ALT cells and impairs cell proliferation. Our findings imply that the CST complex plays an important role in regulating telomere maintenance in ALT cells. - Highlights: • CST localizes at telomeres and ALT-associated PML bodies in ALT cells throughout the cell cycle. • CST is important for promoting telomeric DNA replication in ALT cells. • CST deficiency decreases ECTR formation and increases T-SCE. • CST deficiency impairs ALT cell proliferation and results in multinucleation.

Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

Directory of Open Access Journals (Sweden)

Eun Young Yu

2015-10-01

Full Text Available A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR. These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs. The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

Pattern of AST and ALT changes in Relation to Hemolysis in sickle cell Disease

Directory of Open Access Journals (Sweden)

K. Nsiah

2011-01-01

Full Text Available Background Elevated aminotransferase levels are commonly associated with compromised hepatic integrity from various insults. In sickle cell disease, aspartate transaminase (AST is also released via intravascular hemolysis. This study was done to determine the pattern of changes in AST and alanine transaminase (ALT, in particular the AST:ALT ratio, and to relate these to the hemolytic state, which we consider to be more important than hepatic and cardiac dysfunction in some individuals with sickle cell disease. Methods Serum aminotransferase levels were measured in 330 subjects with sickle cell disease, as well as hemoglobin, reticulocytes, and lactate dehydrogenase. The AST:ALT ratio was designated as a hemolytic marker, and simple and multivariate regression analyses were carried out between this ratio and other hemolytic markers. Results Mean AST and ALT levels were 48.24 % 27.78 and 26.48 % 22.73 U/L, respectively. However, for 49 subjects without sickle cell disease, mean AST and ALT levels were the same, ie, 23.0 U/L. In the subjects with sickle cell disease, the increases in AST levels were far higher than for ALT, supporting its release via intravascular hemolysis. In 95.8% of the subjects with sickle cell disease, the AST:ALT ratio was > 1, but our results did not suggest overt malfunctioning of the liver and heart in the majority of subjects. Conclusion Regression analyses support the use of the AST:ALT ratio as a hemolytic marker, because it has an inverse association with the hemoglobin level. Whether in steady state or in crisis, provided hepatic and cardiac integrity has not been compromised, subjects with sickle cell disease would have higher AST levels due to the hemolytic nature of the condition. This is the first report highlighting the AST:ALT ratio in sickle cell disease.

ALT-I pump limiter results on TEXTOR

International Nuclear Information System (INIS)

Dippel, K.H.; Finken, K.H.; Guthrie, S.E.; Malinowski, M.E.; Pontau, A.E.; Campbell, G.A.; Goebel, D.M.; Conn, R.W.

1985-01-01

The ALT-I pump limiter is used to control hydrogen fluxes from the TEXTOR tokamak. The performance of two different modules, the open fixed geometry (FG) and the closed variable geometry (VG) is discussed. In unpumped scoop limiter operation, the pressure in the ALT-I chamber increases to 3x10 -4 torr(FG) and 2x10 -3 torr(VG). With pumping, the fraction of particles incident on the neutralizer plate that is removed is 25-50%(FG) and 50-80%(VG). These removed particles are estimated to be 2-4(8)%(FG) and 6-13%(VG) of the total plasma outflux (Nsub(e)/tausub(p)). The collection of helium from the plasma using the FG module is approximately half as effective as hydrogen collection. The higher particle removal efficiency for the VG module is attributed to lower neutral backstreaming. (author)

ALT Blood Test: MedlinePlus Lab Test Information

Science.gov (United States)

... K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2 nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Alanine Aminotransferase (ALT); p. 31. Lab ...

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT Phenotype

Directory of Open Access Journals (Sweden)

João P. Amorim

2016-09-01

Full Text Available Telomeres are responsible for protecting chromosome ends in order to prevent the loss of coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and can occur by upregulation of the telomerase enzyme or through a homologous recombination-associated process, the alternative lengthening of telomeres (ALT. The precise mechanisms that govern the activation of ALT or telomerase in tumor cells are not fully understood, although cellular origin may favor one of the other mechanisms that have been found thus far in mutual exclusivity. Specific mutational events influence ALT activation and maintenance: a unifying frequent feature of tumors that acquire this phenotype are the recurrent mutations of the Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX or Death-Domain Associated Protein (DAXX genes. This review summarizes the established criteria about this phenotype: its prevalence, theoretical molecular mechanisms and relation with ATRX, DAXX and other proteins (directly or indirectly interacting and resulting in the ALT phenotype.

Human genome program report. Part 1, overview and progress

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-11-01

This report contains Part 1 of a two-part report to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 consists of the program overview and report on progress.

Synthesis and properties of the metallo-supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]·AgNO3: Ag+/Cu2+ ion exchange and effective antibacterial activity

KAUST Repository

Xu, Feng

2014-01-01

The commercial polymeric anhydride poly(methyl vinyl ether-alt-maleic anhydride) (PVM/MA) is converted by reaction with NaOH to give poly(methyl vinyl ether-alt-mono-sodium maleate) (PVM/Na-MA). By addition of AgNO 3-solution, the formation of the silver(i) supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]·AgNO 3 is reported. Freeze-dried samples of the hydrogel show a mesoporous network of polycarboxylate ligands that are crosslinked by silver(i) cations. In the intact hydrogel, ion-exchange studies are reported and it is shown that Ag+ ions can be exchanged by copper(ii) cations without disintegration of the hydrogel. The silver(i) hydrogel shows effective antibacterial activity and potential application as burn wound dressing. © the Partner Organisations 2014.

Influence of gender, BMI, and ethnicity on serum ALT levels of healthy students of a medical school

International Nuclear Information System (INIS)

Bilal, M.; Tariq, A.; Khan, S.; Quratulain, A.; Tariq, A.; Shahid, M.F.; Khan, M.W.; Naveed, A.K.

2011-01-01

Background: Alanine Aminotransferase (ALT) is an enzyme found in Liver and indicates injury to Hepatocytes. It is influenced by various factors. The objectives of this study were to identify the correlates of ALT activity among healthy medical students of Army Medical College, National University of Sciences and Technology, aged 18-22 years. This was to establish the mean ALT levels of the students and compare them with those in various parts of the world and observe various correlations that exist and factors that may influence ALT levels. Methods: This population included 143 volunteer students (93 men and 50 women) selected on the basis of negative answers to a detailed medical questionnaire including past medical history, drug and alcohol consumption, on the absence of clinical signs of liver disease, on the negativity of serological testing for Hepatitis B and C virus. Results: The mean ALT level of the entire population was 28.7 IU/L. A major sex-difference in ALT value was observed, the mean ALT value being higher in men than in women (32.1+- 21.7 vs. 22.6 +- 9.7 IU/L, p<0.004). According to WHO criteria for Asians, normal BMI was taken from 18.5-23.0 Kg/m/sup 2/. There was a positive significant correlation between serum ALT level and BMI (p<0.002). ALT level strongly correlates with body mass index and gender. There was no significant variation in ALT levels among Punjabis and Sindhis, Balochis, Pathans, and Kashmiris. Conclusion: We suggest the need of taking into account these parameters in a clinical interpretation of ALT level. (author)

Kui kapital veab alt, siis turvaliselt / Aleksander Tsapov

Index Scriptorium Estoniae

Tsapov, Aleksander

2006-01-01

Kuraatorinäitus "Kapital (see veab meid alt)" Tallinna Kunstihoones. Kuraator Simon Sheikh. Fia-Stina Sandlundi, Katya Sanderi, Oliver Ressleri, Ashley Hunti ja Susan Kelly&Stephen Mortoni töödest näitusel

Predictive value of serum ALT and T-cell receptor beta variable chain for HBeAg seroconversion in chronic hepatitis B patients during tenofovir treatment.

Science.gov (United States)

Yang, Jiezuan; Yan, Dong; Guo, Renyong; Chen, Jiajia; Li, Yongtao; Fan, Jun; Fu, Xuyan; Yao, Xinsheng; Diao, Hongyan; Li, Lanjuan

2017-03-01

Effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis B (CHB). Identification of serum indices, including hepatitis B e antigen (HBeAg) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in HBeAg-positive CHB patients. The biochemical, serological, virological parameters, and the frequency of circulating CD4CD25 regulatory T cell (Treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of tenofovir disoproxil fumarate (TDF) treatment. The relationship between the hepatitis B virus (HBV) deoxyribonucleic acid (DNA) and Treg and alanine aminotransferase (ALT) levels was analyzed, respectively. The molecular profiles of T-cell receptor beta variable chain (TRBV) were determined using gene melting spectral pattern. For the seroconverted 12 patients, ALT declined to normal levels by week 24 and remained at this level in subsequent treatment; moreover, the predictive cutoff value of ALT for HBeAg seroconversion (SC) was 41.5 U/L at week 24. The positive correlation between HBV DNA and Treg and ALT was significant in SC patients, but not in non-SC patients. Six TRBV families (BV3, BV11, BV12, BV14, BV20, and BV24) were predominantly expressed in SC patients at baseline. The decline of ALT could be used to predict HBeAg seroconversion for CHB patients during TDF treatment. In addition, the profile of Tregs and TRBVs may be associated with HBeAg seroconversion and could also be a potential indicator for predicting HBeAg SC and treatment outcome for CHB patients.

Division of Waste Management programs. Progress report, July-December 1978

International Nuclear Information System (INIS)

Lerch, R.E.; Allen, C.R.; Richardson, G.L.

1979-07-01

This is the eleventh progress report on Division of Waste Management programs. The report describes progress in the second half of 1978 on the following programs: intermediate-level waste solidification, chemical processing of combustible solid waste, and application of acid digestion to commercial wastes. The latter two programs were combined in October 1978 into a single program, acid digestion of combustible wastes

ALT-I pump limiter experiments

International Nuclear Information System (INIS)

Goebel, D.M.; Conn, R.W.; Campbell, G.A.

1987-09-01

Results from the ALT-I pump limiter experiments in TEXTOR are presented. ALT-I has demonstrated control of the plasma density in a high recycling tokamak by pumping up to 15% of the core efflux. The closed pump limiter designs with restricted entrance geometries to reduce the backflow of neutral gas to the plasma remove over 50% of the ion flux incident on the collection slot. Up to 80% of the entrance ion flux is removed when the edge electron temperature is less than 10 eV and plasma-neutral gas interactions are minimized inside the limiter. Results from a 3-D Monte Carlo neutral gas transport code agree closely with these experimental results. The compound curvature of the head is found to distribute the heat over the surface as predicted in the original designs. Impurity removal experiments demonstrate that significant helium exhaust can be achieved with a pump limiter. During ohmic heating in TEXTOR, the energy and particle confinement times are proportional to the line averaged core density. With ICRH auxiliary heating, tau/sub E/ follow L-mode scaling independent of particle removal by the pump limiter. Pump limiter operation does not directly modify the SOL plasma density and electron temperature, but controls the core plasma density by changing the global recycling at the boundary. The global particle confinement, the particle flux to the limiter, and the edge electron temperature follow the changes in the core density and auxiliary heating power. 25 refs

ALT Strategy, February 2017 - January 2020

OpenAIRE

Deepwell, Maren

2017-01-01

The Association for Learning Technology (ALT) represents individual and organisational Members from all sectors and parts of the UK. Our Membership includes practitioners, researchers and policy makers with an interest in Learning Technology. Our community grows more diverse as Learning Technology has become recognised as a fundamental part of learning, teaching and assessment. Our charitable objective is "to advance education through increasing, exploring and disseminating knowledge in t...

Status and progress of the RERTR Program

International Nuclear Information System (INIS)

Travelli, A.

1996-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1996 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 1995 in collaboration with its many international partners

Status and progress of the RERTR Program

International Nuclear Information System (INIS)

Travelli, A.

1993-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1993 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 1992 in collaboration with its many international partners

Progress of the RERTR program in 1989

International Nuclear Information System (INIS)

Travelli, A.

1991-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1988, the major events, findings, and activities of 1989 are reviewed. (orig.)

The Advanced Limiter Test-I (ALT-I) variable-geometry pump limiter module

International Nuclear Information System (INIS)

Pontau, A.E.; Malinowski, M.E.; Ver Berkmoes, A.A.; Guthrie, S.E.; Watson, R.D.; Goebel, D.M.; Campbell, G.A.

1984-01-01

The ALT-I variable geometry module has been designed to address many of the issues not previously settled by earlier experiments. The goal is to study the basic processes involved in pump limiter operation as well as demonstrate its utility and effect on the plasma. The flexibility and extensive instrumentation of ALT-I will offer a unique opportunity to parameterize operation and facilitate the engineering design of future pump limiters. (orig.)

2010 Annual Progress Report: DOE Hydrogen Program

Energy Technology Data Exchange (ETDEWEB)

2011-02-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.

Science.gov (United States)

Jeyapalan, Jennie N; Mendez-Bermudez, Aaron; Zaffaroni, Nadia; Dubrova, Yuri E; Royle, Nicola J

2008-06-01

Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In approximately 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft-tissue sarcoma in adults and they activate ALT or telomerase with equal frequency, however no TMM has been identified in approximately 50% of liposarcomas. In our study, we have shown that instability at the minisatellite MS32, usually associated with ALT activation, aids the identification of liposarcomas that have recombination-like activity at telomeres in absence of ALT associated PML-bodies (APBs). Furthermore, using single molecule telomere analysis, we have detected complex telomere mutations directly in ALT positive liposarcomas and interestingly in some liposarcomas with an unknown TMM but high MS32 instability. We have shown by sequence analysis that some of these complex telomere mutations must arise by an inter-molecular recombination-like process rather than by deletion caused by t-loop excision or by unequal telomere-sister-chromatid-exchange (T-SCE), which is known to be elevated in ALT cell lines. Preliminary evidence also suggests that inter-molecular recombination events may be processed differently in liposarcomas with APBs compared to those without. In conclusion, we have shown for the first time, that some telomerase negative liposarcomas without APBs have other features associated with ALT, indicating that the incidence of ALT in these tumours has previously been under-estimated. This has major implications for the use of cancer treatments targeted at TMMs. (c) 2008 Wiley-Liss, Inc.

The Progressive Insurance Automotive X PRIZE Education Program

Energy Technology Data Exchange (ETDEWEB)

Robyn Ready

2011-12-31

The Progressive Insurance Automotive X PRIZE Education Program conducted education and outreach activities and used the competition's technical goals and vehicle demonstrations as a means of attracting students and the public to learn more about advanced vehicle technologies, energy efficiency, climate change, alternative fuels, and the science and math behind efficient vehicle development. The Progressive Insurance Automotive X PRIZE Education Program comprised three integrated components that were designed to educate the general public and create a multi-tiered initiative to engage students and showcase the 21st century skills students will need to compete in our global economy: teamwork, creativity, strong literacy, math and science skills, and innovative thinking. The elements included an Online Experience, a National Student Contest, and in person education events and activites. The project leveraged online connections, strategic partnerships, in-classroom, and beyond-the-classroom initiatives, as well as mainstream media. This education program supported by the U.S. Department of Energy (DOE) also funded the specification of vehicle telemetry and the full development and operation of an interactive online experience that allowed internet users to follow the Progressive Insurance Automotive X PRIZE vehicles as they performed in real-time during the Progressive Insurance Automotive X PRIZE competition events.

Presentation and demonstration at Alt-i-lab 2005

NARCIS (Netherlands)

Tattersall, Colin

2005-01-01

These documents were used to accompany the Learning Design presentation and demonstration at Alt-i-lab 2005. The slides were shown during a plenary session describing the interoperability demo. The scenario was used to guide the demonstration process, and the UNFOLD handout was used to illustrate

RESULTS OF ACCELERATED LIFE TESTING OF LCLS-II CAVITY TUNER MOTOR

Energy Technology Data Exchange (ETDEWEB)

Huque, Naeem [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Daly, Edward F. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Pischalnikov, Yuriy [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

2018-04-01

An Accelerated Life Test (ALT) of the Phytron stepper motor used in the LCLS-II cavity tuner has been conducted at JLab. Since the motor will reside inside the cryomodule, any failure would lead to a very costly and arduous repair. As such, the motor was tested for the equivalent of 30 lifetimes before being approved for use in the production cryomodules. The 9-cell LCLS-II cavity is simulated by disc springs with an equivalent spring constant. Plots of the motor position vs. tuner position ' measured via an installed linear variable differential transformer (LVDT) ' are used to measure motor motion. The titanium spindle was inspected for loss of lubrication. The motor passed the ALT, and is set to be installed in the LCLS-II cryomodules.

Division of Waste Management programs. Progress report, January-June 1979

International Nuclear Information System (INIS)

Lerch, R.E.; Allen, C.R.; Crippen, M.D.

1980-10-01

This is the twelfth progress report on Division of Waste Management programs being conducted at the Hanford Engineering Development Laboratory (HEDL) for the United States Department of Energy. The report describes progress in the first half of 1979 on the following programs: Acid Digestion of Combustible Wastes; and Chemical Treatment of Transuranic Contaminated Metals

The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.

Science.gov (United States)

Sumida, Yoshio; Yoshikawa, Toshikazu; Tanaka, Saiyu; Taketani, Hiroyoshi; Kanemasa, Kazuyuki; Nishimura, Tekeshi; Yamaguchi, Kanji; Mitsuyoshi, Hironori; Yasui, Kohichiroh; Minami, Masahito; Naito, Yuji; Itoh, Yoshito

2014-12-01

Physicians often experience difficulties in motivating patients with non-alcoholic fatty liver disease (NAFLD) to undergo lifestyle changes. The aim of this study is to examine whether 'Donations for Decreased alanine aminotransferase (ALT)' (D4D) prosocial behavior incentive can serve as an effective intrinsic motivational factor in comparison with conventional dietary and exercise intervention alone for NAFLD patients. Twenty-five NAFLD patients with elevated ALT were randomly assigned to a control group that received conventional dietary and exercise intervention alone, or a donation group whereby, as an incentive, we would make a monetary donation to the United Nations World Food Programme (WFP) based on the decrease in their ALT levels achieved over 12 weeks, in addition to receiving control intervention. In a donation group, we would donate US$1 to the WFP for every 1 IU/l of decrease in their ALT levels. There were no differences of pre-treatment clinical characteristics between the two groups. Significant reductions of ALT levels were achieved only in a donation group, although post-treatment ALT levels were not different between the two groups. These patients raised a total of $316 for the WFP. Promoting patients' intrinsic motivation by incorporating 'D4D' prosocial behavior incentive into conventional dietary and exercise intervention may provide a means to improve NAFLD. © The Author 2013. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Die Altäre von Selinunt

OpenAIRE

Voigts, Clemens

2014-01-01

In der Dissertation wurden die Altäre von Selinunt, einer griechischen Kolonie auf Sizilien, mit den Methoden der Bauforschung untersucht. Die neun behandelten Brandopferaltäre sind monumentale Quaderbauten, die bis zu 20 m Länge erreichen. Sie stammen aus der Blütezeit Selinunts, dem 6. und 5. Jh. v. Chr. Die Bauten waren bereits im 19. und 20. Jh. freigelegt worden und wurden nun in Bauaufnahmen dokumentiert, zeichnerisch rekonstruiert und zeitlich eingeordnet. Dabei ließ sich an ihnen eine...

Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study

Science.gov (United States)

Ahn, Song Vogue; Baik, Soon Koo; Cho, Youn zoo; Koh, Sang Baek; Huh, Ji Hye; Chang, Yoosoo; Sung, Ki-Chul; Kim, Jang Young

2016-01-01

Aims The ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) is of great interest as a possible novel marker of metabolic syndrome. However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Therefore, our study aimed to evaluate the AST-to-ALT ratio as an incremental predictor of new onset metabolic syndrome in a population-based cohort study. Material and Methods The population-based cohort study included 2276 adults (903 men and 1373 women) aged 40–70 years, who participated from 2005–2008 (baseline) without metabolic syndrome and were followed up from 2008–2011. Metabolic syndrome was defined according to the harmonized definition of metabolic syndrome. Serum concentrations of AST and ALT were determined by enzymatic methods. Results During an average follow-up period of 2.6-years, 395 individuals (17.4%) developed metabolic syndrome. In a multivariable adjusted model, the odds ratio (95% confidence interval) for new onset of metabolic syndrome, comparing the fourth quartile to the first quartile of the AST-to-ALT ratio, was 0.598 (0.422–0.853). The AST-to-ALT ratio also improved the area under the receiver operating characteristic curve (AUC) for predicting new cases of metabolic syndrome (0.715 vs. 0.732, P = 0.004). The net reclassification improvement of prediction models including the AST-to-ALT ratio was 0.23 (95% CI: 0.124–0.337, Pmetabolic syndrome and had incremental predictive value for incident metabolic syndrome. PMID:27560931

μC/OS-II the real-time kennel and its new progress

International Nuclear Information System (INIS)

Shao Beibei

2003-01-01

A lot of effort has been made to spread the application of RTOS in embedded system development in China. RTOS, μC/OS and μC/OS-II, with its opened source code, is well known in embedded systems. Learning RTOS, Using RTOS, becomes more and more popular. The Book of 'Micro C/OS-II The Real-Time Kennel Second Edition' was published in 2002. Here some new progress of the RTOS, especially the safety certifications, the reliability of software is introduced. (authors)

Langmuir probe measurements in the TEXTOR tokamak during ALT-I pump limiter experiments

International Nuclear Information System (INIS)

Goebel, D.M.; Campbell, G.A.; Conn, R.W.; Leung, W.K.; Dippel, K.H.; Finken, K.H.; Thomas, G.J.; Pontau, A.E.

1986-04-01

Langmuir probes have been used to characterize the edge plasma of the TEXTOR tokamak and measure the parameters of the plasma incident on the ALT-I pump limiter during ohmic and ICRH heating. Probes mounted directly on the ALT limiter, and a scanning probe located 90 0 toroidally from the limiter, provide data for the evaluation of pump limiter performance and its effect on the edge plasma. The edge plasma is characterized by density and flux e-folding lengths of about 1.8cm when ALT is the main limiter. These scrape-off lengths do not vary significantly as ALT is moved between the normal 42-46cm minor radii, but increase to over 2.2cm when ALT is inserted to 40cm. The flux to probes at a fixed position in the limiter shadow varies by less than 25% for core density changes of a factor of five. This suggests that the global particle confinement time tau/sub p/, scales as the core density. Estimates from the probes indicate that tau/sub p/ is on the order of the energy confinement time, tau/sub E/. The edge electron temperature, T/sub e/, typically decreases by a factor of two when the core density is raised from 1 to 4 x 10 13 cm -3 . The T/sub e/ profile is essentially flat in the limiter shadow, with values of 10-25 eV depending on the core plasma density and ICRH power. ICRH heating increases the electron temperature and flux in proportion to the coupled power. With ALT as the primary limiter and no direct shadowing, the ion side receives 2 to 3 times the flux of the electron side during both ohmic and ICRH heating. The edge plasma is not directly modified by pump limiter operation, but changes with the core plasma density as particle removal lowers the recycling of neutrals in the boundary

Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals

DEFF Research Database (Denmark)

Sabin, Caroline A; Ryom, Lene; Kovari, Helen

2013-01-01

An inverse association between serum alanine aminotransferase (ALT) levels and the risk of myocardial infarction (MI) has been reported in the general population. We investigated associations between ALT levels and the risk of various cardiovascular and cerebrovascular outcomes in a large cohort ...

Progress of the RERTR program in 1999

International Nuclear Information System (INIS)

Travelli, A.

1999-01-01

This paper describes the progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners during 1999 and discusses planned activities for the coming year

Genel Anestezi Altında Çocukta Diş Tedavisi

OpenAIRE

Gülhan, A.; Sandallı, N.

2013-01-01

ÖZETBu makalede çocuklarda genel anestezi altında diş tedavisinin koşulları anlatıldı ve normal tedavi koşulları sağlanamadığı takdirde, genel anesteziye başvurmanın yararlarına ve sakıncalarına değinildi. Genel anestezi indikasyonları sıralanarak, bunlar arasında en sık rastladığımız «Güç çocuklarım" genci anesteziye başvurmadan Önce hangi yollara başvurularak normal tedavinin deneneceğinden bahsedildi.Bir hastane ortamında genel anestezi altında çalışmaya karar verildikten sonra, bir a...

MENO-II: An AI-Based Programming Tutor.

Science.gov (United States)

Soloway, Elliot; And Others

This report examines the features and performance of the BUG-FINDing component of MENO-II, a computer-based tutor for beginning PASCAL programming students. A discussion of the use of artificial intelligence techniques is followed by a summary of the system status and objectives. The two main components of MENO-II are described, beginning with the…

Peek ja Lepik soovisid varade aresti alt vabastamist

Index Scriptorium Estoniae

2005-01-01

LHV endine töötaja Oliver Peek väidab, et tema vastu esitatud süüdistused on alusetud ja tõendamata ning nõuab oma varade aresti alt vabastamist. Kristjan Lepingu kohtuasja arutamine lükati edasi 21. detsembrile. Endiselt käib uurimine, kui palju väidetavalt teabevargusega raha teeniti

Correlation between Aminotransferase Ratio (AST/ALT and Other Biochemical Parameters in Chronic Liver Disease of Viral Origin

Directory of Open Access Journals (Sweden)

Shah Md Fazlul Karim

2015-03-01

Full Text Available Background: In recent years the ratio of aspartate aminotransferase (AST to alanine aminotransferase (ALT in patients of chronic liver disease (CLD of various origins has gained much attention. This variable is readily available, easy to interpret, and inexpensive and the clinical utility of the AST/ALT ratio in the diagnostic workup of patients with CLD is quite promising. Objective: The present study was designed to find out the link between aminotransferase (AST/ALT ratio with commonly measured biochemical parameters of liver function tests in CLD of viral origin. Materials and method: This cross sectional study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka, Bangladesh. Forty four biopsy proven diagnosed subjects of chronic viral hepatitis without cirrhosis of both sex were selected purposively. With aseptic precaution 5 mL venous blood was collected from each subject and common liver function tests (serum AST, ALT, AST/ALT ratio, alkaline phosphatase, total bilirubin, serum total protein, serum albumin, serum globulin, serum albumin/globulin ratio, prothrombin time and viral serology (HBsAg, Anti HDV antibody, Anti HCV antibody were performed. Data were analyzed by SPSS version 19 for Windows. Pearson’s correlation test was done to determine association between AST/ALT with other biochemical parameters. Results: Mean(±SD age of the study subjects was 32.55±10.55 years (range 20-50 years with 48 (77.7% male and 14 (22.6% female subjects. Pearson’s correlation test was done between AST to ALT ratio with other biochemical parameters and prothrombin time showed significant positive correlation (p <0.01. Conclusion: In our study we found significant positive correlation between AST/ALT with prothrombin time in CLD subjects without cirrhosis.

Synthesis and Properties of the Metallo-Supramolecular Polymer Hydrogel Poly[methyl vinyl ether-alt-mono-sodium maleate]∙AgNO3

KAUST Repository

Al-Dossary, Mona S.

2014-05-01

Gels are a special class of materials which are composed of 3D networks of crosslinked polymer chains that encapsulate liquid/air in the matrix. They can be classified into organogels or hydrogels (organic solvent for organogel and water for hydrogel). For hydrogels that contain metallic elements in the form of ions, the term of metallo-supramolecular polymer hydrogel (MSPHG) is often used. The aim of this project is to develop a kind of new MSPHG and investigate its properties and possible applications. The commercial polymeric anhydride poly(methyl vinyl ether-alt-maleic anhydride) (PVM/MA) is converted by reaction with NaOH to give poly(methyl vinyl ether-alt-monosodium maleate) (PVM/Na-MA). By addition of AgNO3-solution, the formation of the silver(I) supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]∙AgNO3 is obtained. Freeze-dried samples of the hydrogel show a mesoporous network of polycarboxylate ligands that are crosslinked by silver(I) cations. The supercritical CO2 dried silver(I) hydrogel was characterized by FT-IR, SEM-EDAX, TEM, TGA and Physical adsorption (BET) measurements. The intact silver(I) hydrogel was characterized by cryo-SEM. In the intact hydrogel, ion-exchange studies are reported and it is shown that Ag+ ions can be exchanged by copper(II) cations without disintegration of the hydrogel. The silver(I) hydrogel shows effective antibacterial activity and potential application as burn wound dressing.

Altıntop Dilim Konservesi Üretiminde Enzim Kullanımı: I. Kabuk Soyma

Directory of Open Access Journals (Sweden)

Osman Kola

2015-02-01

Full Text Available Bu çalışmada; altıntop dilim konservesi yapımında kabuk soyma ve dilim zarının uzaklaştırılması amaçlarıyla enzim çözeltisi kullanılmasının etkileri araştırılmıştır. Bunun için: önce, çözeltinin meyve kabuğu içine nüfuz ettirilmesi amacıyla uygulanabilecek uygun işlemler, sonra da, enzim çözeltisi uygulamasının kabuk soyma işlemleri üzerindeki etkileri araştırılmıştır. Kabuk soyma işleminde meyvenin; 95 °C sıcaklıktaki suda 5 dakika bekletildikten sonra kapak açma ve kabuk çizme işlemlerini takiben, su ya da %0.5 düzeyindeki Peelzym II çözeltisi içine konulan meyvelerin 1.76 kg/cm2 (25 psi basınç altında 60 saniye süreyle işleme tabi tutulmasının, hem işlemin etkinliği hem de son ürünün kalitesi açısından uygun olabileceği sonucuna varılmıştır.

40 CFR 147.2551 - State-administered program-Class II wells.

Science.gov (United States)

2010-07-01

..., “Re: Application for Primacy in the Regulation of Class II Injection Wells,” March 8, 1982; (5) Letter... Class II Injection Wells under Section 1425 of the Safe Drinking Water Act,” November 1981; (2) Letter...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS...

Status and progress of the RERTR program in the year 2000

International Nuclear Information System (INIS)

Travelli, Armando

2000-01-01

This paper describes the progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners during the year 2000 and discusses the main activities planned for the year 2001. The past year was held by important accomplishments and events for the RERTR program: Four additional shipments containing 503 spent fuel assemblies from foreign research reactors were accepted by the U.S. Altogether, 3,740 spent fuel assemblies from foreign research reactors have been received by the U.S. under the acceptance policy; Postirradiation examinations of three batches of microplates have continued to reveal excellent irradiation behavior of U-Mo dispersion fuels in a variety of compositions and irradiating conditions. Irradiation of two new batches of miniplates of greater sizes is in progress in the ATR to investigate the swelling behavior of these fuels under prototypic conditions. These materials hold the promise of achieving the program goal of developing LEU research reactor fuels with uranium densities in the 8-9 g /cm 3 range; Qualification of the U-Mo dispersion fuels is proceeding on schedule. Test fuel elements with uranium density of 6 g/cm 3 are being fabricated by BWXT and are scheduled to begin undergoing irradiation in the HFR-Petten in the spring of 2001, with a goal of qualifying this fuel by the end of 2003. U-Mo fuel with uranium density of 8-9 g/cm 3 is planned to be qualified by the end of 2005; Joint LEU conversion feasibility studies were completed for HFR-Petten and for SAFARI-1; Significant improvements were made in the design of LEU metal-foil annular targets that would allow efficient production of fission 99 Mo. Irradiations in the RAS-GAS reactor showed that these targets can formed from aluminum tubes, and that the yield and purity of their product from the acidic process were at least as good as those from the HEU Cintichem targets; Progress was made on irradiation testing of

Phase I Report, US DOE GRED II Program

Energy Technology Data Exchange (ETDEWEB)

Fairbank Engineering Ltd.

2003-04-23

Noramex Corporation Inc, a Nevada company, owns a 100% interest in geothermal leases at the Blue Mountain Geothermal Area, Humboldt County, Nevada. The company is exploring the site for a geothermal resource suitable for development for electric power generation or In the spring of 2002, Noramex drilled the first geothermal observation hole at Blue Mountain, under a cost-share program with the U.S Department of Energy (DOE), under the DOE's Geothermal Exploration and Resource Definition (GRED) program, (Cooperative Agreement No. DE-FC04-00AL66972). DEEP BLUE No.1 was drilled to a total depth of 672.1 meters (2205 feet) and recorded a maximum temperature of 144.7 C (292.5 F). Noramex Corporation will now drill a second slim geothermal observation test hole at Blue Mountain, designated DEEP BLUE No.2. The hole will be drilled under a cost-share program with the DOE, under the DOE's Geothermal Exploration and Resource Definition II (GRED II) program, (Cooperative Agreement No. DE-FC04-2002AL68297). This report comprises Phase I of Cooperative Agreement No. DE-FC04-2002AL68297 of the GRED II program. The report provides an update on the status of resource confirmation at the Blue Mountain Geothermal Area, incorporating the results from DEEP BLUE No.1, and provides the technical background for a second test hole. The report also outlines the proposed drilling program for slim geothermal observation test hole DEEP BLUE No.2.

An assessment of racial differences in the upper limits of normal ALT levels in children and the effect of obesity on elevated values.

Science.gov (United States)

Kliethermes, S; Ma, M; Purtell, C; Balasubramanian, N; Gonzalez, B; Layden, T J; Cotler, S J

2017-10-01

Childhood obesity is a risk factor for non-alcoholic fatty liver disease and poses important public health issues for children. Racial differences in alanine aminotransferase (ALT) levels among children have not been described. This study aimed to identify racial differences in upper limit normal (ULN) ALT levels and evaluate the effect of obesity on elevated levels in children without other metabolic risk factors. National Health and Nutrition Examination Surveys and clinical data from the Loyola University Health System were used to determine ULN ALT by race and gender. Quantile regression was used to evaluate the impact of obesity on elevated ALT and to identify potential risk factors for ALT above the ULN. Upper limit normal (ULN) ALT was approximately 28.0 and 21.0-24.0 U/L for boys and girls, respectively. No significant difference in ULN ALT across race was observed. Obesity was significantly associated with elevated ALT; obese children with elevated ALT had values 10 U/L higher than normal-weight children. Racial differences in ALT levels among adults are not evident in children. Obesity, in the absence of metabolic risk factors and other causes of liver disease, is associated with elevated ALT, providing evidence against the concept of healthy obesity in children. © 2016 World Obesity Federation.

Environmental Stress Induces Trinucleotide Repeat Mutagenesis in Human Cells by Alt-Nonhomologous End Joining Repair.

Science.gov (United States)

Chatterjee, Nimrat; Lin, Yunfu; Yotnda, Patricia; Wilson, John H

2016-07-31

Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are implicated in neurodegenerative disease and evolution. Recently, we reported that environmental stresses induce TNR mutagenesis via stress responses and rereplication, with more than 50% of mutants carrying deletions or insertions-molecular signatures of DNA double-strand break repair. We now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, LIG3, and PARP1-suppresses stress-induced TNR mutagenesis, in contrast to the components of homologous recombination and NHEJ, which have no effect. Thus, alt-NHEJ, which contributes to genetic mutability in cancer cells, also plays a novel role in environmental stress-induced TNR mutagenesis. Published by Elsevier Ltd.

MAPLE-II. A program for plotting fault trees

International Nuclear Information System (INIS)

Poucet, A.; Van Den Muyzenberg, C.L.

1987-01-01

The MAPLE II code is an improved version of the MAPLE program for plotting fault trees. MAPLE II has added features which make it a versatile tool for drawing large and complex logic trees. The code is developed as part of a package for computer aided fault tree construction and analysis in which it is integrated and used as a documentation tool. However the MAPLE II code can be used as a separate program which uses as input a structure function of a tree and a description of the events and gates which make up the tree. This report includes a short description of the code and of its features. Moreover it contains the how-to-use and some indications for implementing the code and for adapting it to different graphics systems

Liver stiffness becomes stable in patients with chronic hepatitis C three months after ALT normalization due to antiviral therapy

Directory of Open Access Journals (Sweden)

CHEN Feikai

2013-10-01

Full Text Available ObjectiveTo investigate the time for liver stiffness measurement (LSM to become stable in chronic hepatitis C (CHC patients with elevated alanine aminotransferase (ALT levels after ALT normalization due to antiviral therapy. MethodsCHC patients who sought initial treatment at Peking University People′s Hospital were screened for elevated ALT levels from May 2011. Liver stiffness was determined by FibroScan. A total of 29 patients had been included in the study by September 2012, who were followed up regularly after antiviral treatment. ALT tests were repeated every four weeks and LSM every eight weeks until their medians did not change significantly. Comparisons of matched data at two adjacent time points were made with the non-parametric Wilcoxon test, while multiple comparisons of repeated measurements were performed using Bonferroni correction. Correlation between two variables was analyzed with the Spearman rank test. ResultsPatients were followed up until 24 weeks after antiviral treatment, and 24 patients were included in analysis. The median ALT levels were 64, 26, 21, 20, and 22 U/L at baseline and 4, 8, 12, and 24 weeks, respectively (P= 0.000, 0.006, 0.337, and 0.109 for comparisons between two adjacent values. ALT decreased significantly below 1 ULN at 4 weeks after antiviral therapy and stabilized at 8 weeks. The median LSM values were 8.7, 7.8, 6.8, and 6.7 kPa at baseline and 8, 16, and 24 weeks, respectively (P= 0.009, 0.001, and 0188 for comparisons between two adjacent values. LSM decreased significantly within 16 weeks after antiviral therapy and stabilized afterwards. LSM stabilized 12 weeks after ALT normalization. ConclusionLSM becomes stable in CHC patients with elevated ALT levels three months after ALT normalization due to antiviral therapy.

The medical laboratory issues about recommendation on uniform cutoff values of “normal” ALT in the ACG guidelines

Directory of Open Access Journals (Sweden)

YU Qian

2018-01-01

Full Text Available In the recent American clinical guidelines dealing with laboratory tests for evaluation of liver disease, the American College of Gastroenterology (ACG recommends ALT upper reference limits of 33 U/L for males and 25 U/L for females respectively, and that individuals with ALT above these “normal” cutoffs should be further investigated. Considering the differences between laboratory assays measuring ALT in our country, the standardization of methods and the consistency of results can not be completely ensured. The uniform “normal” range of ALT recommended by the ACG guidelines is largely based on findings from foreign studies and may not be suitable to Chinese population. On the other hand, reference upper/lower limits should not simply be equated with clinical decision thresholds. However, due to improper application of the related concepts of the above medical laboratory issues, simply recommending the uniform reference range of the ALT may lead to overdiagnosis and unnecessary follow-up examinations.

Exploration of Logistics Information Technology (IT) Solutions for the Royal Saudi Naval Force Within the Saudi Naval Expansion Program II (SNEP II)

Science.gov (United States)

2017-12-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT EXPLORATION OF LOGISTICS INFORMATION TECHNOLOGY (IT) SOLUTIONS FOR THE...INFORMATION TECHNOLOGY (IT) SOLUTIONS FOR THE ROYAL SAUDI NAVAL FORCE WITHIN THE SAUDI NAVAL EXPANSION PROGRAM II (SNEP II) 5. FUNDING NUMBERS 6. AUTHOR(S...Expansion Program II (SNEP II). A part of this program includes upgrading and rebuilding its information technology (IT) infrastructure. The United

SEISRISK II; a computer program for seismic hazard estimation

Science.gov (United States)

Bender, Bernice; Perkins, D.M.

1982-01-01

The computer program SEISRISK II calculates probabilistic ground motion values for use in seismic hazard mapping. SEISRISK II employs a model that allows earthquakes to occur as points within source zones and as finite-length ruptures along faults. It assumes that earthquake occurrences have a Poisson distribution, that occurrence rates remain constant during the time period considered, that ground motion resulting from an earthquake is a known function of magnitude and distance, that seismically homogeneous source zones are defined, that fault locations are known, that fault rupture lengths depend on magnitude, and that earthquake rates as a function of magnitude are specified for each source. SEISRISK II calculates for each site on a grid of sites the level of ground motion that has a specified probability of being exceeded during a given time period. The program was designed to process a large (essentially unlimited) number of sites and sources efficiently and has been used to produce regional and national maps of seismic hazard.}t is a substantial revision of an earlier program SEISRISK I, which has never been documented. SEISRISK II runs considerably [aster and gives more accurate results than the earlier program and in addition includes rupture length and acceleration variability which were not contained in the original version. We describe the model and how it is implemented in the computer program and provide a flowchart and listing of the code.

Recent results of high p(T) physics at the CDF II

Energy Technology Data Exchange (ETDEWEB)

Tsuno, Soushi; /Okayama U.

2005-02-01

The Tevatron Run II program has been in progress since 2001. The CDF experiment has accumulated roughly five times as much data as did Run I, with much improved detectors. Preliminary results from the CDF experiment are presented. The authors focus on recent high p{sub T} physics results in the Tevatron Run II program.

Effect of Ramadan fasting on alanine transferase (ALT in nonalcoholic fatty liver disease (NAFLD

Directory of Open Access Journals (Sweden)

Hojjatolah Rahimi

2017-09-01

Full Text Available Background: The effects of Ramadan fasting on NAFLD are unknown and there are very limited studies have done in this area. Some nutritional and behavioral changes of fasting people in Ramadan can affect NAFLD. These include nutrition with high fat and calories, altering in weight and sleep and low physical activity. We decided to evaluate the effects of these changes on one of the important indicators of deterioration of NAFLD, ALT.Methods: Sixty patients with fatty liver disease performed two consecutive ALT exams before and after Ramadan month of whom finally 34 were fasting and 26 nonfasting. After collecting data they were divided in two groups of fasting and nonfasting and compared using SPSS software.Results: Mean ALT change from before to after Ramadan was higher and positive in fasting (+7.38±8.47 IU/L compared to nonfastng patients that was negative (-0.12±10.15 IU/L (P=0.002 and this change was mainly in patients who had fasted 21-30 days.Conclusion: Ramadan fasting may increase ALT. It is needed to perform more studies in patients with NAFLD during Ramadan fasting with larger sample size and in various conditions especially weight loss with patients’ education for observing dietary regimen.

Serum ALT levels as a surrogate marker for serum HBV DNA levels in HBeAg-negative pregnant women.

Science.gov (United States)

Sangfelt, Per; Von Sydow, Madeleine; Uhnoo, Ingrid; Weiland, Ola; Lindh, Gudrun; Fischler, Björn; Lindgren, Susanne; Reichard, Olle

2004-01-01

In Stockholm, Sweden, the majority of pregnant women positive for hepatitis B surface antigen (HBsAg) are hepatitis Be antigen (HBeAg) negative. Newborns to HBeAg positive mothers receive vaccination and hepatitis B immunoglobulin (HBIg). Newborns to HBeAg negative mothers receive vaccine and HBIg only if the mothers have elevated ALT levels. The aim of this study was to retrospectively evaluate ALT levels as a surrogate marker for HBV DNA levels in HBeAg negative carrier mothers. Altogether 8947 pregnant women were screened for HBV markers from 1999 to 2001 at the Virology Department, Karolinska Hospital. Among mothers screened 192 tested positive for HBsAg (2.2%). 13 of these samples could not be retrieved. Of the remaining 179 sera, 8 (4%) tested positive for HBeAg and 171 (95.5%) were HBeAg negative. Among the HBeAg negative mothers, 9 had HBV DNA levels > 10(5) copies/ml, and of these 7 had normal ALT levels indicating low sensitivity of an elevated ALT level as a surrogate marker for high HBV DNA level. Furthermore, no correlation was found between ALT and HBV DNA levels. Hence, it is concluded that the use of ALT as a surrogate marker for high viral replication in HBeAg negative mothers could be questioned.

Semiannual progress report for the Idaho Geothermal Program, April 1-September 30, 1981

Energy Technology Data Exchange (ETDEWEB)

Parker, J.T. (ed.)

1982-01-01

Modifications incorporated in the 5-MW Pilot Power Plant at Raft River Geothermal Test Site, system operational testing and maintenance activities at that plant, and the water treatment program's corrosion studies are summarized. Progress is reported on performance tests of the ORNL condenser and the direct-contact heat exchanger in the Prototype Power Plant. Production-injection tests associated with pump installation in monitor wells at Raft River are reported. Case studies conducted and publications prepared for the program of low-to moderate-temperature hydrothermal resource development are also reported. Monitoring activities and studies of the environmental program at Raft River are described and two new areas of research under the Environmental Support Injection Research Program: pressure monitoring, and dispersion studies. Progress of three successful proposers under the User-Coupled Confirmation Drilling Program is summarized. A program to encourage use of geothermal energy at Federal facilities was developed and initiated. Investigation of direct use of hydrothermal energy is reported. Progress is reported on the marketing Assistance Program, through which technical information and assistance are provided to potential users and developers of geothermal resources. Also reported is progress on DOE's Program Opportunity Notice (PON) Program demonstration projects and the Program Research and Development Announcement (PRDA) Program study projects.

Electron-beam-fusion progress report, January--June 1976

International Nuclear Information System (INIS)

1976-10-01

Research progress is reported for the following areas: (1) Proto I, (2) Proto II, (3) EBFA, (4) power flow, (5) contract progress reports, (6) progress in the Sandia program, (7) repetitively operated pulse generator development, (8) electron beam power from inductive storage, (9) fusion target design, (10) beam physics research, (11) power flow, (12) heavy ion fusion, (13) particle beam source development, (14) beam target interaction and target response studies, (15) diagnostic development, and (16) hybrid systems

Alt a 1 allergen homologs from Alternaria and related taxa: analysis of phylogenetic content and secondary structure.

Science.gov (United States)

Hong, Soon Gyu; Cramer, Robert A; Lawrence, Christopher B; Pryor, Barry M

2005-02-01

A gene for the Alternaria major allergen, Alt a 1, was amplified from 52 species of Alternaria and related genera, and sequence information was used for phylogenetic study. Alt a 1 gene sequences evolved 3.8 times faster and contained 3.5 times more parsimony-informative sites than glyceraldehyde-3-phosphate dehydrogenase (gpd) sequences. Analyses of Alt a 1 gene and gpd exon sequences strongly supported grouping of Alternaria spp. and related taxa into several species-groups described in previous studies, especially the infectoria, alternata, porri, brassicicola, and radicina species-groups and the Embellisia group. The sonchi species-group was newly suggested in this study. Monophyly of the Nimbya group was moderately supported, and monophyly of the Ulocladium group was weakly supported. Relationships among species-groups and among closely related species of the same species-group were not fully resolved. However, higher resolution could be obtained using Alt a 1 sequences or a combined dataset than using gpd sequences alone. Despite high levels of variation in amino acid sequences, results of in silico prediction of protein secondary structure for Alt a 1 demonstrated a high degree of structural similarity for most of the species suggesting a conservation of function.

Enhanced surveillance program FY97 accomplishments. Progress report

Energy Technology Data Exchange (ETDEWEB)

Mauzy, A. [ed.; Laake, B. [comp.

1997-10-01

This annual report is one volume of the Enhanced Surveillance Program (ESP) FY97 Accomplishments. The complete accomplishments report consists of 11 volumes. Volume 1 includes an ESP overview and a summary of selected unclassified FY97 program highlights. Volume 1 specifically targets a general audience, reflecting about half of the tasks conducted in FY97 and emphasizing key program accomplishments and contributions. The remaining volumes of the accomplishments report are classified, organized by program focus area, and present in technical detail the progress achieved in each of the 104 FY97 program tasks. Focus areas are as follows: pits; high explosives; organics; dynamics; diagnostics; systems; secondaries; nonnuclear materials; nonnuclear components; and Surveillance Test Program upgrades.

Mutational analysis of the activator of late transcription, Alt , in the lactococcal bacteriophage TP901-1

DEFF Research Database (Denmark)

Pedersen, Margit; Hammer, Karin

2007-01-01

An activator protein, Alt, synthesized during the early state of lytic infection is required for transcription of the late operon in the lactococcal phage TP901-1. In order to identify amino acid residues in the Alt protein required for activation of the TP901-1 late promoter, Plate, hydroxylamine...

[Impact analysis of shuxuetong injection on abnormal changes of ALT based on generalized boosted models propensity score weighting].

Science.gov (United States)

Yang, Wei; Yi, Dan-Hui; Xie, Yan-Ming; Yang, Wei; Dai, Yi; Zhi, Ying-Jie; Zhuang, Yan; Yang, Hu

2013-09-01

To estimate treatment effects of Shuxuetong injection on abnormal changes on ALT index, that is, to explore whether the Shuxuetong injection harms liver function in clinical settings and to provide clinical guidance for its safe application. Clinical information of traditional Chinese medicine (TCM) injections is gathered from hospital information system (HIS) of eighteen general hospitals. This is a retrospective cohort study, using abnormal changes in ALT index as an outcome. A large number of confounding biases are taken into account through the generalized boosted models (GBM) and multiple logistic regression model (MLRM) to estimate the treatment effects of Shuxuetong injections on abnormal changes in ALT index and to explore possible influencing factors. The advantages and process of application of GBM has been demonstrated with examples which eliminate the biases from most confounding variables between groups. This serves to modify the estimation of treatment effects of Shuxuetong injection on ALT index making the results more reliable. Based on large scale clinical observational data from HIS database, significant effects of Shuxuetong injection on abnormal changes in ALT have not been found.

Constance mirror program: progress and plans

International Nuclear Information System (INIS)

Klinkowstein, R.E.; Mauel, M.E.; Irby, J.; Smullin, L.D.; Voldman, S.

1981-01-01

The basic construction of the Constance II experiment was completed during August of 1979 with the installation of the first set of Ioffe bars. Since then, several improvements have been made and several experimental investigations have been completed. These are: (1) the improved, liquid-nitrogen cooled, Ioffe bars have been constructed and installed, (2) a diverter coil was installed between the guide and mirror field region, (3) the 100 kW ICRF generator have been constructed and tested, (4) the data acquisition system has been completed, (5) confinement studies have determined the optimum hot-ion operation of the machine with Titanium and pulsed-gas plasma guns, (6) the density, temperature, and radius of the plasma have been measured, (7) ion-cyclotron fluctuations have been observed, their bandwidth measured, and the conditions for its appearance investigated, and (8) preliminary ECRH data have been collected demonstrating resonance heating. In addition, development of the diagnostics has continued. For example, new x-ray diagnostics have been designed and purchased, and progress on the Thomson scattering has been made. Finally, a new hot cathode gun, which will soon be tested, has been designed and constructed. This report discusses the current state of the mechanics of the Constance II experiment as well as the physics results that have been gathered to date. In addition, the motivation, background, and future plans for the Constance II experiment will be reviewed

Defense Small Business Innovation Research Program (SBIR). Abstracts of Phase 2 Awards 1992

Science.gov (United States)

1992-01-01

into diamond. 2 ARMY SBIR PHASE II AWARDS Transition metals were alloyed at relatively low temperatures to form a thin layer of silicides which lowered...structures. D~uring the phase I program. lDamaskos . Intc. succCssfullN delltonstratet! a cs stpssiol loter :,1I formed by depositinig alte rnat intg layers ...Heights Drive Office: CRI)FC Aica. fiI 96701 Co ntract #: 1)AAA 1 5-93-C-0002if Phonie: 1808)l 486-5381 Ill: Dr, T- J, G. Rasbould Title: Urease -Linked

Baseline Gas Turbine Development Program. Fourteenth quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Schmidt, F W; Wagner, C E

1976-04-30

Progress is reported for a Baseline Gas Turbine Development Program sponsored by the Heat Engine Systems Branch, Division of Transportation Energy Conservation (TEC) of the Energy Research and Development Administration (ERDA). Structurally, this program is made up of three parts: (1) documentation of the existing automotive gas turbine state-of-the-art; (2) conduction of an extensive component improvement program; and (3) utilization of the improvements in the design, and building of an Upgraded Engine capable of demonstrating program goals.

Ephedra alte (Joint Pine: An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan

Directory of Open Access Journals (Sweden)

Jamal R. Qasem

2012-01-01

Full Text Available A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

Ephedra alte (Joint Pine): An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan

Science.gov (United States)

Qasem, Jamal R.

2012-01-01

A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked. PMID:22645486

Ephedra alte (joint pine): an invasive, problematic weedy species in forestry and fruit tree orchards in Jordan.

Science.gov (United States)

Qasem, Jamal R

2012-01-01

A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008-2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

Space Power Program Semiannual Progress Report for period ending June 30, 1963

Energy Technology Data Exchange (ETDEWEB)

Miller, A. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

1963-10-11

This is a report of progress on the Oak Ridge National Laboratory's research and development program on nuclear power plants for electrical power production in space vehicles. The work is carried out under AEG Reactor Experiments, Fuels, and Materials, and Reactor Component programs. Research and development work is under way on the stainless steel boiling-potassium reactor and the Medium Power Reactor Experiment, boiling alkali metal heat transfer, high-temperature and refractory alloys, fuel material, and space reactor shielding, particularly in connection with SNAP 2, 8, 10, and 50. Many of these OREL efforts are directed toward the development of a specific type of power plant, but they also furnish a significant contribution of scientific and engineering information needed in other programs on advanced SNAP systems. Progress on research and development directly related to the Medium Power Reactor Experiment (MPRE) is presented mostly in Part I of this report. Progress on the MPRE will, in the future, be reported on a quarterly basis. The form of the reporting will alternate from MPRE Quarterly Progress Reports to Space Power Semiannual Progress Reports.

German NDE within PISC-II program

International Nuclear Information System (INIS)

Deuster, G.; Schmuelling, W.

1987-01-01

Within PISC-I, which was finished at the end of the seventies, three uncladded 200 mm thick plates were available. In this program ten European countries were participating. The test specimens came out of the American HSST-program. A series of testing according to the ASME-procedure were performed and in addition several alternative techniques. The manufacturing defects dominated but were unrealistic large. There was a lack of small cracklike defects. The PISC-II program was initiated in the early eighties with participation of twelve European countries and in addition USA, Japan and Canada. A lot of realistic service induced cracklike defects were available especially what concerned their position and size. (orig.)

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

Directory of Open Access Journals (Sweden)

Chi-Ting Horng

2014-11-01

Full Text Available Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA. Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively. Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function.

Phase II study of Gleevec® plus hydroxyurea (HU) in adults with progressive or recurrent meningioma.

Science.gov (United States)

Reardon, David A; Norden, Andrew D; Desjardins, Annick; Vredenburgh, James J; Herndon, James E; Coan, April; Sampson, John H; Gururangan, Sridharan; Peters, Katherine B; McLendon, Roger E; Norfleet, Julie A; Lipp, Eric S; Drappatz, Jan; Wen, Patrick Y; Friedman, Henry S

2012-01-01

We prospectively evaluated the efficacy and safety of imatinib plus hydroxyurea in patients with progressive/recurrent meningioma. A total of 21 patients with progressive/recurrent meningioma were enrolled in this dual center, single-arm, phase II trial. All patients received 500 mg of hydroxyurea twice a day. Imatinib was administered at 400 mg/day for patients not on CYP3A enzyme inducing anti-epileptic drugs (EIAEDs) and at 500 mg twice a day for patients on EIAEDs. The primary endpoint was progression-free survival at 6 months (PFS-6) and secondary endpoints were safety, radiographic response rate, and overall survival (OS). Best radiographic response was stable disease and was observed in 14 patients (67%). PFS-6 for all patients, those with grade I tumors (n = 8) and those with grade II or III tumors (n = 13) was 61.9, 87.5 and 46.2%, respectively. Patients with grade II or III tumors had poorer PFS and OS than those with grade I tumors, (P = 0.025 and P = 0.018) respectively. The only grade 3 or greater adverse event occurring in ≥ 10% of patients was anemia (10%). Imatinib plus hydroxyurea is well tolerated among patients with meningioma but has modest anti-tumor activity for this indication.

KAFEPA-II program users' manual and description

International Nuclear Information System (INIS)

Suk, H. C.; Hwang, W.; Kim, B. G.; Sim, K. S.; Heo, Y. H.; Byun, T. S.; Park, G. S.

1992-04-01

KAFEPA-II is a computer program for simulating the behaviour of UO 2 fuel elements under normal operating conditions of a CANDU reactor. It computes the one-dimensional temperature distribution and thermal expansion of the fuel pellets. The amount of gas released during irradiation of the fuel is also computed. Thermal expansion and gas pressure inside the fuel element are then used to compute the strains and stresses in the sheath. This document is intended as a user's manual and description for KAFEPA-II. (Author)

Progression along the Bipolar Spectrum: A Longitudinal Study of Predictors of Conversion from Bipolar Spectrum Conditions to Bipolar I and II Disorders

Science.gov (United States)

Alloy, Lauren B.; Urošević, Snežana; Abramson, Lyn Y.; Jager-Hyman, Shari; Nusslock, Robin; Whitehouse, Wayne G.; Hogan, Michael

2011-01-01

Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I diagnosis. Consistent with hypotheses derived from the clinical literature and the Behavioral Approach System (BAS) model of bipolar disorder, and controlling for relevant variables (length of follow-up, initial depressive and hypomanic symptoms, treatment-seeking, and family history), high BAS sensitivity (especially BAS Fun Seeking) predicted a greater likelihood of progression to bipolar II disorder, whereas early age of onset and high impulsivity predicted a greater likelihood of progression to bipolar I (high BAS sensitivity and Fun-Seeking also predicted progression to bipolar I when family history was not controlled). The interaction of high BAS and high Behavioral Inhibition System (BIS) sensitivities also predicted greater likelihood of progression to bipolar I. We discuss implications of the findings for the bipolar spectrum concept, the BAS model of bipolar disorder, and early intervention efforts. PMID:21668080

Mark II containment lead plant program load evaluation and acceptance criteria

International Nuclear Information System (INIS)

1978-10-01

The report, prepared by the Office of Nuclear Reactor Regulation, addresses the portion of the Mark II owner's program that provides a generic methodology for establishing design basis LOCA and safety relief valve loads for the lead Mark II facilities (Zimmer, Shoreham, and LaSalle), i.e., the lead plant program. The report includes an evaluation of the Mark II owner's load methodology, a description of load methodologies that we find acceptable for use in the individual plant unique assessments, and the basis for the stated conclusions

Regulation of Tumor Progression by Programmed Necrosis

Directory of Open Access Journals (Sweden)

Su Yeon Lee

2018-01-01

Full Text Available Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (e.g., glucose deprivation, which occurs because of insufficient blood supply. This results in necrotic cell death in the core region of solid tumors. Necrotic cells release their cellular cytoplasmic contents into the extracellular space, such as high mobility group box 1 (HMGB1, which is a nonhistone nuclear protein, but acts as a proinflammatory and tumor-promoting cytokine when released by necrotic cells. These released molecules recruit immune and inflammatory cells, which exert tumor-promoting activity by inducing angiogenesis, proliferation, and invasion. Development of a necrotic core in cancer patients is also associated with poor prognosis. Conventionally, necrosis has been thought of as an unregulated process, unlike programmed cell death processes like apoptosis and autophagy. Recently, necrosis has been recognized as a programmed cell death, encompassing processes such as oncosis, necroptosis, and others. Metabolic stress-induced necrosis and its regulatory mechanisms have been poorly investigated until recently. Snail and Dlx-2, EMT-inducing transcription factors, are responsible for metabolic stress-induced necrosis in tumors. Snail and Dlx-2 contribute to tumor progression by promoting necrosis and inducing EMT and oncogenic metabolism. Oncogenic metabolism has been shown to play a role(s in initiating necrosis. Here, we discuss the molecular mechanisms underlying metabolic stress-induced programmed necrosis that promote tumor progression and aggressiveness.

Acquisition: Implementation of the DoD Management Control Program for Navy Acquisition Category II and III Programs

National Research Council Canada - National Science Library

2004-01-01

... deviations in cost, schedule, and performance requirements in acquisition program baselines for Acquisition Category II and III programs and in identifying whether program managers are reporting...

40 CFR 147.50 - State-administered program-Class II wells.

Science.gov (United States)

2010-07-01

... Carry Out Underground Injection Control Program Relating to Class II Wells as Described in Federal Safe... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Alabama... application: (a) Incorporation by reference. The requirements set forth in the State statutes and regulations...

A Styrene-alt-Maleic Acid Copolymer Is an Effective Inhibitor of R5 and X4 Human Immunodeficiency Virus Type 1 Infection

Directory of Open Access Journals (Sweden)

Vanessa Pirrone

2010-01-01

Full Text Available An alternating copolymer of styrene and maleic acid (alt-PSMA differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties. We hypothesized that alt-PSMA would have activity against human immunodeficiency virus type 1 (HIV-1 comparable to other polyanions, such as the related compound, poly(sodium 4-styrene sulfonate (PSS. In assays using cell lines and primary immune cells, alt-PSMA was characterized by low cytotoxicity and effective inhibition of infection by HIV-1 BaL and IIIB as well as clinical isolates of subtypes A, B, and C. In mechanism of action assays, in which each compound was added to cells and subsequently removed prior to HIV-1 infection (“washout” assay, alt-PSMA caused no enhancement of infection, while PSS washout increased infection 70% above control levels. These studies demonstrate that alt-PSMA is an effective HIV-1 inhibitor with properties that warrant further investigation.

2013 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

none,

2013-12-01

The 2013 Annual Progress Report summarizes fiscal year 2013 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

2014 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

none,

2014-11-01

The 2014 Annual Progress Report summarizes fiscal year 2014 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

Satyapal, Sunita [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

2011-11-01

The 2011 Annual Progress Report summarizes fiscal year 2011 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; education; market transformation; and systems analysis.

Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE) in children admitted to a tertiary hospital.

Science.gov (United States)

Anjos, Alessandra Marques dos; Nunes, Magda Lahorgue

2009-09-01

To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE) in children admitted at the emergency and followed in a tertiary hospital. Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. During the study, 30 (4.2%) children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73%) and term infants (70%). Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.

A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway

Directory of Open Access Journals (Sweden)

Wen Li

2017-10-01

Full Text Available Background/Aims: ALT1 is a novel long non-coding RNA derived from the alternatively spliced transcript of the deleted in lymphocytic leukemia 2 (DLEU2. To date, ALT1 biological roles in human vascular endothelial cells have not been reported. Methods: ALT1 was knocked down by siRNAs. Cell proliferation was analyzed by cck-8. The existence and sequence of human ALT1 were identified by 3’ rapid amplification of cDNA ends. The interaction between lncRNA and proteins was analyzed by RNA-Protein pull down assay, RNA immunoprecipitation, and mass spectrometry analysis. Results: ALT1 was expressed in human umbilical vein endothelial cells (HUVECs. The expression of ALT1 was significantly downregulated in contact-inhibited HUVECs and in hypoxia-induced, growth-arrested HUVECs. Knocking down of ALT1 inhibited the proliferation of HUVECs by G0/G1 cell cycle arrest. We observed that angiotensin converting enzyme Ⅱ(ACE2 was a direct target gene of ALT1. Knocking-down of ALT1 or its target gene ACE2 could efficiently decrease the expression of cyclin D1 via the enhanced ubiquitination and degradation, in which HIF-1α and protein von Hippel-Lindau (pVHL might be involved. Conclusion: The results suggested the human long non-coding RNA ALT1 is a novel regulator for cell cycle of HUVECs via ACE2 and cyclin D1 pathway.

Progress on the degraded piping program - Phase II. Battelle Columbus Division

International Nuclear Information System (INIS)

Wilkowski, Gery; Ahmad, J.; Barnes, C.; Brust, F.; Guerrieri, D.; Kramer, G.; Landow, M.; Marschall, C.; Nakagaki, M.; Papaspyropoulos; Scott, P.

1988-01-01

The overall objective of the Degraded Piping Program is to verify and improve simple estimation schemes to predict the fracture behavior of circumferentially cracked pipe. The program is limited to quasi-static fracture and cracks in straight pipe. There are a variety of materials, flaw geometries, pipe sizes, and loading conditions evaluated. The Degraded Piping Program,which has been extended for one more year, will supply results that provide a basis for regulatory decisions regard applications for leak-before-break (LBB) and In-service flaw assessment. The significance of our results are summarized relative to how they may affect regulatory technical needs. The scope of the work in The Degraded Piping Program includes both analytical and experimental efforts. The experimental efforts have concentrated on testing circumferentially cracked pipe at 550 F (288 C) under si-static loading. Many of the tasks within this program were undertaken with the objective of determining if any detailed efforts were needed. This is true for both the analytical and experimental efforts. i e of the tasks have been slightly expanded during the course of the gram, while others were found to be of lesser concern and further efforts in those areas were not pursued. The results of this summary include the efforts of the third year. These efforts have contributed considerably to the understanding of the application of elastic-plastic fracture mechanics to nuclear piping systems. Rather than listing the significant technical contributions, these contributions are summarized below in relation to their application to LBB analyses, in-service flaw assessment criteria, and (3) material characterization and unusual behavior of nuclear piping materials at light water reactor (LWR) temperatures

Consolidated fuel reprocessing. Program progress report, April 1-June 30, 1980

Energy Technology Data Exchange (ETDEWEB)

1980-09-01

This progress report is compiled from major contributions from three programs: (1) the Advanced Fuel Recycle Program at ORNL; (2) the Converter Fuel Reprocessing Program at Savannah River Laboratory; and (3) the reprocessing components of the HTGR Fuel Recycle Program, primarily at General Atomic and ORNL. The coverage is generally overview in nature; experimental details and data are limited.

Exoskeletal meal assistance system (EMAS II) for progressive muscle dystrophy patient.

Science.gov (United States)

Hasegawa, Yasuhisa; Oura, Saori

2011-01-01

This paper introduces a 4-DOFs exoskeletal meal assistance system (EMAS II) for progressive muscle dystrophy patient. It is generally better for the patient to use his/her hands by himself in daily life because active works maintain level of residual functions, health and initiative of him/her. The EMAS II that has a new joystick-type user interface device and three-DOFs on a shoulder part is enhanced for an easier operation and more comfortable support on eating, as the succeeding model of the previous system that has two-DOFs on a shoulder. In order to control the 4-DOFs system by the simple user interface device, the EMAS II simulates upper limb motion patterns of a healthy person. The motion patterns are modeled by extracting correlations between the height of a user's wrist joint and that of the user's elbow joint at the table. Moreover, the EMAS II automatically brings user's hand up to his/her mouth or back to a table when he/she pushes a preset switch on the interface device. Therefore a user has only to control a position of his/her wrist to pick or scoop foods and then flip the switch to start automatic mode, while a height of the elbow joint is automatically controlled by the EMAS II itself. The results of experiments, where a healthy subject regarded as a muscle dystrophy patient eats a meal with EMAS II, show that the subject finished her meal in a natural way in 18 minutes 40 seconds which was within a recommended time of 30 minutes. © 2011 IEEE

Alte Harfe. Vollständige Sammlung alter estnischer Volkslieder : Vorrede / Jakob Hurt

Index Scriptorium Estoniae

Hurt, Jakob, 1839-1907

2005-01-01

Eessõna rmt. : Hurt, Jakob. Vana kannel. 1. kogu : täieline kogu vanu eesti rahvalaulusid = Alte Harfe : vollständige Sammlung alter estnischen Volkslieder. Tartu, 1875-1886. - (Eesti Kirjameeste Seltsi toimetised ; 3)

THE CHIMERIC ALT-VASTUS LATERALIS FREE FLAP IN RECONSTRUCTION OF ADVANCED BRONJ OF THE MAXILLA

Directory of Open Access Journals (Sweden)

Francesca Toia

2015-04-01

Full Text Available ntroduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disorders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with disease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed uneventfully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.

2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

None

2015-12-23

The 2015 Annual Progress Report summarizes fiscal year 2015 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; and market transformation.

Recent operating experiences and programs at EBR-II

International Nuclear Information System (INIS)

Lentz, G.L.

1984-01-01

Experimental Breeder Reactor No. II (EBR-II) is a pool-type, unmoderated, sodium-cooled reactor with a design power of 62.5 MWt and an electrical generation capability of 20 MW. It has been operated by Argonne National Laboratory for the US government for almost 20 years. During that time, it has operated safely and has demonstrated stable operating characteristics, high availability, and excellent performance of its sodium components. The 20 years of operating experience of EBR-II is a valuable resource to the nuclear community for the development and design of future LMFBR's. Since past operating experience has been extensively reported, this report will focus on recent programs and events

Full-scale mark II CRT program facility description report

International Nuclear Information System (INIS)

Namatame, Ken; Kukita, Yutaka; Ito, Hideo; Yamamoto, Nobuo; Shiba, Masayoshi

1980-03-01

Started in fiscal year 1977, the Full-Scale Mark II CRT (Containment Response Test) Program is proceeding for the period of five years. The primary objective of the CRT Program is to provide a data base for evaluation of the pressure suppression pool hydrodynamic loads associated with a postulated loss-of-coolant accident in the BWR Mark II containment system. The test facility was designed and constructed from fiscal year 1977 to 1978, and completed in March 1979. It is 1/18 in volume and has a wetwell which is a full-scale replica of one 20 0 -sector of that of a reference Mark II. This report describes design concepts, dimensions and constructions of the test facility, as well as specifications, locations and installation schemes of the measuring equipments. Results of soil structure inspection, vacuum breaker test and shaker test of the containment shell are given in the appendices. (author)

2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

Satyapal, Sunita [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2017-02-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

Popovich, Neil

2015-12-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

2012 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

2012-12-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

Alt und Alt gleich Neu / Peter J. Strehmel

Index Scriptorium Estoniae

Strehmel, Peter J.

1994-01-01

Hortus Musicus - Andres Mustonen: Himmel / Earth / Heaven / Erde: 1200-1600, Medieval Renaissance (CD I "Instrumental Music", CD II "Vocal Music"). Erdenklang 40692-1+2; Hortus Musicus - Andres Mustonen: Himmel / Earth / Heaven / Erde: Gregorianische Chorale, Plainchants. Erdenklang 40712

Plasma physics research (Tokapole II). Technical progress report, October 1, 1981-December 31, 1983

International Nuclear Information System (INIS)

1983-01-01

Progress during the 27-month period, October 1, 1981 to December 31, 1983 on Tokapole II research is described. Tokapole II is a 4-node poloidal divertor tokamak that can also be run as an octupole. Research during this period has concentrated on studies of discharges with safety factor q less than one and on the identification of the shear Alfven wave resonance. Other topics include measurements of the loop voltage reduction through ECRH startup, plasma gun refueling, fluctuations and transport, pumped limiter studies, plasma-wall interactions, diagnostic development, polarization of electron cyclotron emission, and poloidal ohmic heating

Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT

DEFF Research Database (Denmark)

Alssema, Marjan; Rijkelijkhuizen, Josina M; Holst, Jens Juul

2013-01-01

OBJECTIVE: To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN: A population......-based study. METHODS: A total of 163 persons with normal glucose metabolism (NGM), 20 with intermediate hyperglycaemia and 20 with type 2 diabetes aged 40-65 years participated. Participants received a mixed meal and oral glucose load on separate occasions. Glucagon-like peptide 1 (GLP-1), glucose......-dependent insulinotropic polypeptide (GIP) and glucagon profiles were analysed as total area under the curve (tAUC) and incremental area under the curve. RESULTS: In diabetic patients compared with persons with NGM, we found increased GLP-1 secretion (tAUC per hour) following oral glucose (23.2 pmol/l (95% CI 17...

Alternative Teacher Preparation Programs. Title II News You Can Use

Science.gov (United States)

Office of Postsecondary Education, US Department of Education, 2015

2015-01-01

Title II of the "Higher Education Act of 1965" ("HEA"), as amended in 2008 by the "Higher Education Opportunity Act," requires states to report annually on key elements of their teacher preparation programs and requirements for initial teacher credentialing, kindergarten through 12th grade. "Title II News You Can…

Biomaterial properties evaluation of poly(vinyl acetate- alt-maleic anhydride)/chitosan nanocapsules

Science.gov (United States)

Raţă, Delia Mihaela; Popa, Marcel; Chailan, Jean-François; Zamfir, Carmen Lăcrămioara; Peptu, Cătălina Anişoara

2014-08-01

Nanocapsules with diameter around 100 nm based on a natural polymer (chitosan) and a synthetic polymer poly(vinyl acetate- alt-maleic anhydride) [poly(MAVA)] by interfacial condensation method were prepared. The present study proposes a new type of biocompatible nanocapsules based on poly(vinyl acetate- alt-maleic anhydride-chitosan) (MCS) able to become a reliable support for inclusion and release of drugs. The spherical shape of the nanocapsules was evidenced by scanning electron microscopy. Nanocapsules presented a good Norfloxacin loading and release capacity. Haemocompatibility tests have demonstrated that the nanocapsules present a low toxicity and a good compatibility with sanguine medium. The biocompatibility properties of the nanocapsules after their intraperitoneal administration in rats were evidenced by histopathological examination of different organs (brain, liver, kidney, and lung). The results are encouraging and the nanocapsules can be used as controlled drug delivery systems.

2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-03-09

The 2016 Annual Progress Report summarizes fiscal year 2016 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; market transformation; and Small Business Innovation Research projects.

F-35 Joint Strike Fighter: Preliminary Observations on Program Progress

Science.gov (United States)

2016-03-23

current fighter aircraft. The cost of extending the lives of current fighter aircraft and acquiring other major weapon systems, while continuing to... Norway . Ongoing Manufacturing and Reliability Progress Continue Page 12 GAO-16-489T rework, and repair costs have remained steady over...Program Progress Why GAO Did This Study With estimated acquisition costs of nearly $400 billion, the F-35 Joint Strike Fighter—also known as the

40 CFR 147.2201 - State-administered program-Class II wells

Science.gov (United States)

2010-07-01

... Application to Oil, Gas, and Geothermal Resource Operations, sections .051.02.02.000 to .051.02.02.080... wells 147.2201 Section 147.2201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Texas § 147.2201 State-administered program—Class II wells The UIC program for Class II wells in the...

Electrodril system field test program. Phase II: Task C-1-deep drilling system demonstration. Final report for Phase II: Task C-1

Energy Technology Data Exchange (ETDEWEB)

Taylor, P D

1981-04-01

The Electrodril Deep Drilling System field test demonstrations were aborted in July 1979, due to connector problems. Subsequent post test analyses concluded that the field replacable connectors were the probable cause of the problems encountered. The designs for both the male and female connectors, together with their manufacturing processes, were subsequently modified, as was the acceptance test procedures. A total of nine male and nine female connectors were manufactured and delivered during the 2nd Quarter 1980. Exhaustive testing was then conducted on each connector as a precursor to formal qualification testing conducted during the month of October 1980, at the Brown Oil Tool test facility located in Houston, Texas. With this report, requirements under Phase II, Task C-1 are satisfied. The report documents the results of the connector qualification test program which was successfully completed October 28, 1980. In general, it was concluded that connector qualification had been achieved and plans are now in progress to resume the field test demonstration program so that Electrodril System performance predictions and economic viability can be evaluated.

Pyrophosphate heart scintigram in children with progressive muscular dystrophy

Energy Technology Data Exchange (ETDEWEB)

Duska, F; Nesvadba, Z; Zdansky, P; Novak, J; Kubicek, J; Kafka, P; Vizda, J; Mazurova, Y

1984-08-01

A pyrophosphate heart scintigram was obtained in 16 boys with progressive muscular dystrophy Duchenne. All of them showed pathological ECG findings and high plasma levels of CK, AST, ALT and LD. In 4 patients the scintigram was distinctly positive and in further 3 it reached borderline values. The remaining 9 boys had normal scintigraphic findings. Those with a positive heart scintigram had very high plasma levels of the enzymes under study which was suggestive of current progression of the disease. There was, however, no relation between heart scintigraphy and the affliction of the skeletal muscles expressed by means of an index.

Phase II study of Gleevec® plus hydroxyurea (HU) in adults with progressive or recurrent meningioma

OpenAIRE

Reardon, David A.; Norden, Andrew D.; Desjardins, Annick; Vredenburgh, James J.; Herndon, James E.; Coan, April; Sampson, John H.; Gururangan, Sridharan; Peters, Katherine B.; McLendon, Roger E.; Norfleet, Julie A.; Lipp, Eric S.; Drappatz, Jan; Wen, Patrick Y.; Friedman, Henry S.

2011-01-01

We prospectively evaluated the efficacy and safety of imatinib plus hydroxyurea in patients with progressive/recurrent meningioma. A total of 21 patients with progressive/recurrent meningioma were enrolled in this dual center, single-arm, phase II trial. All patients received 500 mg of hydroxyurea twice a day. Imatinib was administered at 400 mg/day for patients not on CYP3A enzyme inducing anti-epileptic drugs (EIAEDs) and at 500 mg twice a day for patients on EIAEDs. The primary endpoint wa...

Clinico-biochemical factors to early predict biliary etiology of acute pancreatitis: age, female gender, and ALT.

Science.gov (United States)

Zarnescu, N O; Costea, R; Zarnescu Vasiliu, E C; Neagu, S

2015-01-01

Background/ Aims: Despite the existence of an easy tool to diagnose biliary tract disease as an etiology for acute pancreatitis (AP), the sensitivity of abdominal ultrasound is around 80%, which can be even lower in certain conditions. We have retrospectively reviewed data of 146 patients admitted for acute pancreatitis between 1999 and 2013. Bivariate analysis for clinical and biochemical variables was performed with respect to etiology of AP (biliary versus non-biliary). Multivariate analysis was performed by using binary logistic regression. There were 87 males (59.6%) and 59 females (40.4%), with a median age of 51. The etiology of acute pancreatitis was biliary in 71 patients (48.6%). Bivariate analysis found the following as significant association (p=0.001) with biliary pancreatitis: older age, female gender, and elevated AST, ALT. A binary logistic regression analysis identified as predictor factors for biliary etiology of acute pancreatitis: age OR = 1.031 (95% CI 1.004 - 1.059, p = 0.024), sex (female) OR = 2.34 (95% CI 1.022 - 5.359, p = 0.044) and ALT OR = 1.004 (95% CI 1.001 - 1.007, p =0.004). The two clinical scores included the three variables (A.S.ALT scores) in categorical format were generated and then checked with the ROC curves (areas under curve are 0.768 and 0.778). Age, female gender, and elevated ALT can help identifying cases with biliary etiology of acute pancreatitis.

Progress in light ion beam fusion research on PBFA II

International Nuclear Information System (INIS)

Cook, D.L.; Allshouse, G.O.; Bailey, J.

1986-01-01

PBFA II is a 100 TW pulsed power accelerator constructed at Sandia National Laboratories for use in the Light Ion Fusion Program. The objective of PBFA II is to accelerate and focus upon an inertial confinement fusion (ICF) target a lithium beam with sufficient energy, power, and power density to perform ignition scaling experiments. The technologies used in PBFA II include: (1) primary energy storage and compression with 6 MV, low-inductance Marx generators, (2) pulse forming in water-insulated, water-dielectric lines with self-closing water switches, (4) voltage addition in vacuum using self-magnetically-insulated biconic transmission lines, (5) inductive energy storage and pulse compression using a fast-opening plasma erosion switch, (6) beam formation using a magnetically-insulated ion diode, and (7) space-charge and current-neutralized beam propagation to the target in a gas-filled cell. The first multimodule shot was on December 11, 1985. The plans for PBFA II include development and demonstration of the pulse-shaping techniques which are necessary for high-gain target compressions. Following a modification of the accelerator which will probably include an ''extraction'' ion diode, a 4- to 5-meter plasma channel for beam bunching during propagation, and a target chamber located beneath the accelerator, temporally-shaped ion beam pulses will be available for pulse-shaped target experiments. (author)

ELEVATED ALANINE AMINOTRANSFERASE (ALT IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C

Directory of Open Access Journals (Sweden)

Fernando Lopes GONÇALES Jr.

1998-07-01

Full Text Available The determination of aminotranferases levels is very useful in the diagnosis of hepatopathies. In recent years, an elevated serum ALT level in blood donors has been associated with an increased risk of post-transfusion hepatitis (PTH. The purpose of the study was to research the factors associated with elevated ALT levels in a cohort of voluntary blood donors and to evaluate the relationship between increased ALT levels and the development of hepatitis C (HCV infection. 166 volunteer blood donors with elevated ALT at the time of their first donation were studied. All of the donors were questioned about previous hepatopathies, exposure to hepatitis, exposure to chemicals, use of medication or drugs, sexual behaviour, contact with blood or secretions and their intake of alcohol. Every three months, the serum levels of AST, ALT, alkaline phosphatase, gamma glutamyl transpeptidase, cholesterol, triglyceride and glycemia are assessed over a two year follow-up. The serum thyroid hormone levels as well as the presence of auto-antibodies were also measured. Abdominal ultrasound was performed in all patients with persistently elevated ALT or AST levels. A needle biopsy of liver was performed in 9 donors without definite diagnostic after medical investigation. The presence of anti-HCV antibodies in 116 donors were assayed again the first clinical evaluation. At the end of follow-up period (2 years later 71 donors were tested again for the presence of anti-HCV antibodies. None of donors resulted positive for hepatitis B or hepatitis C markers during the follow-up. Of the 116 donors, 101 (87% had persistently elevated ALT serum levels during the follow-up. Obesity and alcoholism were the principal conditions related to elevated ALT serum levels in 91/101 (90.1% donors. Hypertriglyceridemia, hypercholesterolemia, hypothyroidism and diabetes mellitus also were associated with increased ALT levels. Only 1/101 (0.9% had mild chronic active non A-G viral

2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program (Book)

Energy Technology Data Exchange (ETDEWEB)

2011-11-01

In the past year, the DOE Hydrogen and Fuel Cells Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

DSLR Double Star Astrometry Using an Alt-Az Telescope

Science.gov (United States)

Frey, Thomas; Haworth, David

2014-07-01

The goal of this project was to determine if the double star's angular separation and position angle measurements could be successfully measured with a motor driven, alt-azimuth Dobsonian-mounted Newtonian telescope (without a field rotator), and a digital single-lens reflex (DSLR) camera. Additionally, the project was constrained by using as much existing equipment as much as possible, including an Apple MacBook Pro laptop and a Canon T2i camera. This project was additionally challenging because the first author had no experience with astrophotography.

The pyrophosphate heart scintigram in children with progressive muscular dystrophy

International Nuclear Information System (INIS)

Duska, F.; Nesvadba, Z.; Zdansky, P.; Novak, J.; Kubicek, J.; Kafka, P.; Vizda, J.; Mazurova, Y.; Karlova Univ., Hradec Kralove; Karlova Univ., Hradec Kralove

1984-01-01

A pyrophosphate heart scintigram was obtained in 16 boys with progressive muscular dystrophy Duchenne. All of them showed pathological ECG findings and high plasma levels of CK, AST, ALT and LD. In 4 patients the scintigram was distinctly positive and in further 3 it reached borderline values. The remaining 9 boys had normal scintigraphic findings. Those with a positive heart scintigram had very high plasma levels of the enzymes under study which was suggestive of current progression of the disease. There was, however, no relation between heart scintigraphy and the affliction of the skeletal muscles expressed by means of an index. (orig.) [de

The influence of critical thinking skills on performance and progression in a pre-registration nursing program.

Science.gov (United States)

Pitt, Victoria; Powis, David; Levett-Jones, Tracy; Hunter, Sharyn

2015-01-01

The importance of developing critical thinking skills in preregistration nursing students is recognized worldwide. Yet, there has been limited exploration of how students' critical thinking skill scores on entry to pre-registration nursing education influence their academic and clinical performance and progression. The aim of this study was to: i) describe entry and exit critical thinking scores of nursing students enrolled in a three year bachelor of nursing program in Australia in comparison to norm scores; ii) explore entry critical thinking scores in relation to demographic characteristics, students' performance and progression. This longitudinal correlational study used the Health Sciences Reasoning Test (HSRT) to measure critical thinking skills in a sample (n=134) of students, at entry and exit (three years later). A one sample t-test was used to determine if differences existed between matched student critical thinking scores between entry and exit points. Academic performance, clinical performance and progression data were collected and correlations with entry critical thinking scores were examined. There was a significant relationship between critical thinking scores, academic performance and students' risk of failing, especially in the first semester of study. Critical thinking scores were predictive of program completion within three years. The increase in critical thinking scores from entry to exit was significant for the 28 students measured. In comparison to norm scores, entry level critical thinking scores were significantly lower, but exit scores were comparable. Critical thinking scores had no significant relationship to clinical performance. Entry critical thinking scores significantly correlate to academic performance and predict students risk of course failure and ability to complete a nursing degree in three years. Students' critical thinking scores are an important determinant of their success and as such can inform curriculum development and

Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: post-progression outcomes from the phase II IMvigor210 study.

Science.gov (United States)

Necchi, A; Joseph, R W; Loriot, Y; Hoffman-Censits, J; Perez-Gracia, J L; Petrylak, D P; Derleth, C L; Tayama, D; Zhu, Q; Ding, B; Kaiser, C; Rosenberg, J E

2017-12-01

Conventional criteria for tumor progression may not fully reflect the clinical benefit of immunotherapy or appropriately guide treatment decisions. The phase II IMvigor210 study demonstrated the efficacy and safety of atezolizumab, a programmed death-ligand 1-directed antibody, in patients with platinum-treated locally advanced or metastatic urothelial carcinoma. Patients could continue atezolizumab beyond Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 progression at the investigator's discretion: this analysis assessed post-progression outcomes in these patients. Patients were treated with atezolizumab 1200 mg i.v. every 3 weeks until loss of clinical benefit. Efficacy and safety outcomes in patients who experienced RECIST v1.1 progression and did, or did not, continue atezolizumab were analyzed descriptively. In total, 220 patients who experienced progression from the overall cohort (n = 310) were analyzed: 137 continued atezolizumab for ≥ 1 dose after progression, 19 received other systemic therapy, and 64 received no further systemic therapy. Compared with those who discontinued, patients continuing atezolizumab beyond progression were more likely to have had a baseline Eastern Cooperative Oncology Group performance status of 0 (43.1% versus 31.3%), less likely to have had baseline liver metastases (27.0% versus 41.0%), and more likely to have had an initial response to atezolizumab (responses in 11.7% versus 1.2%). Five patients (3.6%) continuing atezolizumab after progression had subsequent responses compared with baseline measurements. Median post-progression overall survival was 8.6 months in patients continuing atezolizumab, 6.8 months in those receiving another treatment, and 1.2 months in those receiving no further treatment. Atezolizumab exposure-adjusted adverse event frequencies were generally similar before and following progression. In this single-arm study, patients who continued atezolizumab beyond RECIST v1

Kilowatt isotope power system. Phase II plan. Volume I. Phase II program plan

International Nuclear Information System (INIS)

1978-01-01

The development of a Kilowatt Isotope Power System (KIPS) was begun in 1975 for the purpose of satisfying the power requirements of satellites in the 1980's. The KIPS is a 238 PuO 2 -fueled organic Rankine cycle turbine power system to provide a design output of 500 to 2000 W. Phase II of the overall 3-phase KIPS program is described. This volume presents a program plan for qualifying the organic Rankine power system for flight test in 1982. The program plan calls for the design and fabrication of the proposed flight power system; conducting a development and a qualification program including both environmental and endurance testing, using an electrical and a radioisotope heat source; planning for flight test and spacecraft integration; and continuing ground demonstration system testing to act as a flight system breadboard and to accumulate life data

Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE in children admitted to a tertiary hospital Prevalência de epilepsia e crises epilépticas como causa de eventos com aparente risco de vida (ALTE em crianças internadas em hospital terciário

Directory of Open Access Journals (Sweden)

Alessandra Marques dos Anjos

2009-09-01

Full Text Available OBJECTIVE: To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE in children admitted at the emergency and followed in a tertiary hospital. METHOD: Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. RESULTS: During the study, 30 (4.2% children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73% and term infants (70%. Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. CONCLUSION: Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.OBJETIVO: Determinar a prevalência e características clínicas de crises epilépticas e epilepsia como causa de eventos com aparente risco de vida (ALTE em crianças atendidas na emergência e acompanhadas em hospital terciário. MÉTODO: Estudo transversal com coleta prospectiva de dados através de protocolo específico para identificação da etiologia de ALTE. RESULTADOS: Foram diagnosticadas 30 crianças com ALTE perfazendo 4.2% das crianças internadas no período do estudo. Houve predominância no sexo masculino (73% e em neonatos a termo (70%. História prévia de doenças neurológicas no período neonatal e atraso no desenvolvimento neuropsicomotor ocorreram respectivamente em 13.4% e 10% dos casos. A investigação etiológica identificou 13.4% dos casos relacionados a epilepsia ou crise convulsivas e 50% idiopáticos. Apesar destes pacientes terem apresentados episódios recorrentes em nenhum caso havia a suspeita prévia de epilepsia. CONCLUSÃO: Ao investigar

DOG -II input generator program for DOT3.5 code

International Nuclear Information System (INIS)

Hayashi, Katsumi; Handa, Hiroyuki; Yamada, Koubun; Kamogawa, Susumu; Takatsu, Hideyuki; Koizumi, Kouichi; Seki, Yasushi

1992-01-01

DOT3.5 is widely used for radiation transport analysis of fission reactors, fusion experimental facilities and particle accelerators. We developed the input generator program for DOT3.5 code in aim to prepare input data effectively. Formar program DOG was developed and used internally in Hitachi Engineering Company. In this new version DOG-II, limitation for R-Θ geometry was removed. All the input data is created by interactive method in front of color display without using DOT3.5 manual. Also the geometry related input are easily created without calculation of precise curved mesh point. By using DOG-II, reliable input data for DOT3.5 code is obtained easily and quickly

Nuclear air cleaning programs in progress in France

International Nuclear Information System (INIS)

Mulcey, P.

1991-01-01

A short presentation is given of the nuclear air cleaning programs in progress in France with respect to pressurized water reactors, fuel reprocessing plants, radioactive waste management facilities, and the dismantling of nuclear facilities. The effects of fires in rooms and ventilation ducts in all nuclear facilities is being studied and computer simulation codes are being developed. A brief review of filter development and filter testing is also presented

Integral Fast Reactor Program annual progress report, FY 1994

International Nuclear Information System (INIS)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, J.J.

1994-12-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1994. Technical accomplishments are presented in the following areas of the IFR technology development activities: metal fuel performance; pyroprocess development; safety experiments and analyses; core design development; fuel cycle demonstration; and LMR technology R ampersand D

Status of the RERTR program: overview, progress and plans

International Nuclear Information System (INIS)

Travelli, A.

1985-01-01

The status of the US Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 . Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U 3 Si-Al fuel with approx.7 g U/cm 3 is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals

Commercial Alpha Waste Program. Quarterly progress report, January--March, 1975

International Nuclear Information System (INIS)

Cooley, C.R.

1975-10-01

This is the fourth quarterly progress report on the Commercial Alpha Waste Program being conducted at the Hanford Engineering Development Laboratory (HEDL) for the Division of Nuclear Fuel Cycle and Production, U. S. Energy Research and Development Administration. Data on waste composition for fuel reprocessing operations are discussed as well as information on radwaste generation at nuclear power reactors. Progress to date on development of the acid digestion process for treating combustible waste is discussed including initial studies using a critically safe tray digester. Data on alpha waste generation and product storage are also presented

Progress in the US ICF Program

International Nuclear Information System (INIS)

Sluyter, M.M.

1996-01-01

The ICF Program has made exciting progress in the past year towards its goal of the achievement of fusion ignition and gain in the laboratory. A series of experiments on the Nova laser facility has resolved the major technical issues involved in the design of an ignition target. A baseline target has been designed that ignites (calculationally) with a nominal drive of 1.35 MJ (at 351 nm). In parallel, a detailed conceptual design for the National Ignition Facility (NIF-a 1.8 MJ glass laser) has been completed and a successful laser beam line prototype has validated its architecture. As a result, the Department of Energy has requested funding for the preliminary design for the NIF from the U.S. Congress. With these developments, the attainment of the long-sought goal is in sight. In addition, two new laser facilities (OMEGA Upgrade and Nike) have recently been completed, and ion-beam fusion driver development is encouraging. Their availability expands the capability of the program to perform advanced ICF and plasma experiments. copyright 1996 American Institute of Physics

Full-Scale Mark II CRT Program data report, 1

International Nuclear Information System (INIS)

Namatame, Ken; Kukita, Yutaka; Yamamoto, Nobuo; Shiba, Masayoshi

1979-12-01

The Full-Scale Mark II CRT (Containment Response Test) Program was initiated in April 1976 to provide a full-scale data basis for the evaluation of the pressure suppression pool hydrodynamic loads associated with a hypothetical LOCA in a BWR Mark II Containment. The test facility, completed in March 1979, is 1/18 in volume of a typical 1100 MWe Mark II, and has a wetwell which is a full-scale replica of one 20 0 -sector of that of the reference Mark II. The present report documents experimental data from TEST 0002, a medium size (100 mm) water blowdown test, performed by Hitachi Ltd. for JAERI as the second of the four shakedown tests. Test data is provided for the vessel depressurization, the pressure and temperature responses in the test containment, and especially for the chugging phenomena associated with low flux steam condensation in the pool. (author)

Integral Fast Reactor Program. Annual progress report, FY 1992

Energy Technology Data Exchange (ETDEWEB)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1993-06-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R&D.

Progress of the RERTR program in 2001

International Nuclear Information System (INIS)

Travelli, A.

2002-01-01

This paper describes the 2001 progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners. Postirradiation examinations of microplates have continued to reveal excellent irradiation behavior of U-Mo dispersion fuels in a variety of compositions and irradiating conditions. Irradiation of two new batches of mini plates of greater sizes was completed in the ATR to investigate the swelling behavior of these fuels under prototypic conditions. These materials hold the promise of achieving the program goal of developing LEU research reactor fuels with uranium densities in the 8-9 g/cm 3 range. Qualification of the U-Mo dispersion fuels has been declared by a patent issue involving KAERI. Test fuel elements with uranium density of 6 g/cm 3 are being fabricated by BWXT and are expected to begin undergoing irradiation in the HFR-Petten reactor around March 2003, with a goal of qualifying this fuel by mid 2005. U-Mo fuel with uranium density of 8-9 g/cm 3 is expected to be qualified by mid 2007. Final irradiation tests of LEU 99 Mo targets in the RAS-GAS reactor at BATAN, in Indonesia, had to be postponed because of the 9/11 attacks, but the results collected to date indicate that these targets will soon be ready for commercial production. Excellent cooperation is also in progress with the CNEA in Argentina, MDSN/ AECL in Canada, and ANSTO in Australia. Irradiation testing of five WWR-M2 tube-type fuel assemblies fabricated by the NZChK and containing LEU UO 2 dispersion fuel was successfully completed within the Russian RERTR program. A new LEU U-Mo pin-type fuel that could be used to convert most Russian-designed research reactors has been developed by VNIJNM and is ready for testing. Four additional shipments containing 822 spent fuel assemblies from foreign research reactors were accepted by the U.S. by September 30, 2001. Altogether, 4'562 spent fuel assemblies from foreign research

Progress of the RERTR program in 2001

Energy Technology Data Exchange (ETDEWEB)

Travelli, A. [Technology Development Division Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439-4841 (United States)

2002-07-01

This paper describes the 2001 progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners. Postirradiation examinations of microplates have continued to reveal excellent irradiation behavior of U-Mo dispersion fuels in a variety of compositions and irradiating conditions. Irradiation of two new batches of mini plates of greater sizes was completed in the ATR to investigate the swelling behavior of these fuels under prototypic conditions. These materials hold the promise of achieving the program goal of developing LEU research reactor fuels with uranium densities in the 8-9 g/cm{sup 3} range. Qualification of the U-Mo dispersion fuels has been declared by a patent issue involving KAERI. Test fuel elements with uranium density of 6 g/cm{sup 3} are being fabricated by BWXT and are expected to begin undergoing irradiation in the HFR-Petten reactor around March 2003, with a goal of qualifying this fuel by mid 2005. U-Mo fuel with uranium density of 8-9 g/cm{sup 3} is expected to be qualified by mid 2007. Final irradiation tests of LEU {sup 99}Mo targets in the RAS-GAS reactor at BATAN, in Indonesia, had to be postponed because of the 9/11 attacks, but the results collected to date indicate that these targets will soon be ready for commercial production. Excellent cooperation is also in progress with the CNEA in Argentina, MDSN/ AECL in Canada, and ANSTO in Australia. Irradiation testing of five WWR-M2 tube-type fuel assemblies fabricated by the NZChK and containing LEU UO{sub 2} dispersion fuel was successfully completed within the Russian RERTR program. A new LEU U-Mo pin-type fuel that could be used to convert most Russian-designed research reactors has been developed by VNIJNM and is ready for testing. Four additional shipments containing 822 spent fuel assemblies from foreign research reactors were accepted by the U.S. by September 30, 2001. Altogether, 4'562 spent fuel

Full-scale mark II CRT program data report, (5)

International Nuclear Information System (INIS)

Kukita, Yutaka; Namatame, Ken; Yamamoto, Nobuo; Takeshita, Isao; Shiba, Masayoshi

1980-03-01

The Full-Scale Mark II CRT (Containment Response Test) Program was initiated in 1977 to provide a data base for evaluation of the LOCA hydrodynamic loads for the Mark II pressure suppression system. The test facility is 1/18 in volume and has a wetwell which is a fullscale replica of one 20 0 -sector of that of a reference Mark II. This report documents test data obtained from TEST 2101, which is a medium size (74 mm) water break test performed on April 27, 1979. TEST 2101 was designed to roughly approximate an intermediate break accident in which so-called chugging phenomenon associated with low-flux steam condensation is anticipated to continue for a longer duration than in a large break accident. (author)

Status and progress of the RERTR program in the year 2004

International Nuclear Information System (INIS)

Travelli, A.

2005-01-01

The overall status of the RERTR program at the time of the last RERTR meeting is reviewed and the progress achieved since that meeting is described. In the fuel area, unexpected failures of LEU U-Mo dispersion plates and tubes under irradiation testing have prompted a revision of the plans to qualify these fuels. While potential solutions to the difficulties with U-Mo dispersion fuels are being explored in collaboration with our international partners, greater emphasis has been placed on accelerating development of monolithic LEU U-Mo fuel. The feasibility of converting several Russian-designed research reactors to LEU fuels has been addressed, and progress has been made in the development of LEU based 99 Mo production processes. The Russian RERTR program has made significant advances. A very important event of 2004 was the US DOE establishment of the Global Threat Reduction Initiative (GTRI). This new program accelerates and combines under the same US DOE management several programs, including RERTR, which aim to secure, remove, or dispose of, nuclear and other radioactive materials throughout the world that are vulnerable to theft by terrorists. (author)

Altın Fiyatlarının Yapay Sinir Ağları ile Tahmini ve Bir Uygulama

Directory of Open Access Journals (Sweden)

Rıdvan YÜKSEL

2016-03-01

Full Text Available Bu çalışmada altın fiyatlarını yapay sinir ağları ile öngörmek amacıyla, altın fiyatlarını etkileyebileceği düşünülen değişkenler olan Gümüş fiyatları, Brent Petrol fiyatları, ABD doları/ EUR paritesi, EuroNext100 endeksi, Amerika Dow Jones Endeksi, 13 Hafta vadeli ABD bonosu faiz oranı ve ABD TÜFE endeksi kullanılarak modeller kurulmuştur. Yapay sinir ağları ile kurulan modellerden elde edilen tahmin sonuçları, gerçek değerler ile R2, RMSE, MAE ve MAPE (% gibi performans kriterleri hesaplanarak karşılaştırılmıştır. Elde edilen bulgular yapay sinir ağlarının altın fiyatlarının tahmininde başarı ile kullanılabileceğini göstermektedir. Yapılan duyarlılık analizinin sonuçları değerlendirildiğinde altın fiyatlarını etkileyen faktörlerin başında gümüş ve petrol fiyatlarının geldiği tespit edilmiştir.

Information literacy progression within the Environmental science program at Linköping University

Directory of Open Access Journals (Sweden)

Kajsa Gustafsson Åman

2013-12-01

Full Text Available Since the Environmental Science program at Linköping University started 1998 the author has been liaison librarian. The program is a three-year candidate program with approximately 60 students enrolled per year. Information literacy is of vital importance for the teachers and the students. Collaboration between the liaison librarian, the teachers and the administrator is the fundament. During the years a curriculum for Information literacy has evolved. The initiative for the evolvement comes from both librarian and teachers. The program consists today of fifteen different parts with education in information literacy with a progression during the three-year program. Special concern is given to progression, learning design, learning environments and quality development. An important part is appendixes in connection to the student essay. The appendixes consist of reflections on the search of information for the essay in order to make the students more conscious about their Information Literacy processes.

[Progress in synthetic biology of "973 Funding Program" in China].

Science.gov (United States)

Chen, Guoqiang; Wang, Ying

2015-06-01

This paper reviews progresses made in China from 2011 in areas of "Synthetic Biology" supported by State Basic Research 973 Program. Till the end of 2014, 9 "synthetic biology" projects have been initiated with emphasis on "microbial manufactures" with the 973 Funding Program. Combined with the very recent launch of one project on "mammalian cell synthetic biology" and another on "plant synthetic biology", Chinese "synthetic biology" research reflects its focus on "manufactures" while not giving up efforts on "synthetic biology" of complex systems.

Mathematics Programming on the Apple II and IBM PC.

Science.gov (United States)

Myers, Roy E.; Schneider, David I.

1987-01-01

Details the features of BASIC used in mathematics programming and provides the information needed to translate between the Apple II and IBM PC computers. Discusses inputing a user-defined function, setting scroll windows, displaying subscripts and exponents, variable names, mathematical characters and special symbols. (TW)

Integral Fast Reactor Program annual progress report, FY 1991

International Nuclear Information System (INIS)

1992-06-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

Integral Fast Reactor Program. Annual progress report, FY 1993

Energy Technology Data Exchange (ETDEWEB)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1994-10-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D.

Integral Fast Reactor Program. Annual progress report, FY 1993

International Nuclear Information System (INIS)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1994-10-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D

Recommendations for Cycle II of National Water-Quality Assessment (NAWQA) Program

Science.gov (United States)

,; Mallard, Gail E.; Armbruster, Jeffrey T.; Broshears, Robert E.; Evenson, Eric J.; Luoma, Samuel N.; Phillips, Patrick J.; Prince, Keith R.

1999-01-01

The Planning Team for the U.S. Geological Survey (USGS) National Water-Quality Assessment (NAWQA) Program defines a successful NAWQA Program as one that makes a balanced contribution to study-unit issues, national issues, and to the pursuit of scientific knowledge. Using this criterion, NAWQA has been a success. The program has provided important new knowledge and understanding of scientific processes, and insights into the occurrence and distribution of contaminants that have been key to local and national policy decisions. Most of the basic design characteristics of NAWQA's first decade (1991-2000), hereafter called cycle I) remain appropriate as the program enters its second decade (cycle II) in 2001. In cycle II, the program has the opportunity to build on its successful base and to evolve to take advantage of the knowledge generated in cycle I. In addition to this expected evolution, NAWQA must also make some changes to compensate for the fact that program funding has not kept pace with inflation. An important theme for the second cycle of NAWQA will be the integration of knowledge across scales and across disciplines. The question that drove the NAWQA design in the first cycle was "How is water quality related to land use?" Cycle II will build upon what was learned in cycle I and use land-use and water-quality gradients to identify and understand potential sources of various constituents and the processes affecting transport and fate of those constituents and their effects on receptors. The understanding we gain from applying this approach will be relevant to the interests of policymakers, regulatory agencies, and resource managers.

The Energy-Related Inventions Program: A decade of commercial progress

Energy Technology Data Exchange (ETDEWEB)

Brown, M.A.; Franchuk, C.A. (Oak Ridge National Lab., TN (United States)); Wilson, C.R. (Tennessee Univ., Knoxville, TN (United States))

1991-12-01

This report provides information on the recent commercial progress of inventions supported by the US Department of Energy's Energy-Related Inventions Programs (ERIP). It describes the results of the latest in a series of ERIP evaluation projects that have been completed since 1980. It focuses on the economic impacts of the program, notably sales and employment benefits. The period of interest is 1980 through 1990. The evaluation is based on data collected through mail and telephone surveying of 143 participants in the Program. As of October 1989, a total of 486 inventions were recommended to DOE by the National Institute for Standards and Technology, which screens all submitted inventions in terms of technical merit, potential for commercial success, and potential energy impact. By the end of 1990, at least 109 of these inventions had entered the market, generating total cumulative sales of more than $500 million. With $25.7 million in grants awarded from 1975 through 1990, and $63.1 million in program appropriations over the same period, ERIP has generated a 20:1 return in terms of sales values to grants, and an 8:1 return in sales versus program appropriations. It is estimated that 25% of all ERIP inventions had achieved sales by the end of 1990. While it is difficult to make exact comparisons between these percentages and other indicators of the success rates of technological innovations as a whole, the ERIP figures remain impressive. The commercial progress of spin-off technologies is also documented.

The Energy-Related Inventions Program: A decade of commercial progress

Energy Technology Data Exchange (ETDEWEB)

Brown, M.A.; Franchuk, C.A. [Oak Ridge National Lab., TN (United States); Wilson, C.R. [Tennessee Univ., Knoxville, TN (United States)

1991-12-01

This report provides information on the recent commercial progress of inventions supported by the US Department of Energy`s Energy-Related Inventions Programs (ERIP). It describes the results of the latest in a series of ERIP evaluation projects that have been completed since 1980. It focuses on the economic impacts of the program, notably sales and employment benefits. The period of interest is 1980 through 1990. The evaluation is based on data collected through mail and telephone surveying of 143 participants in the Program. As of October 1989, a total of 486 inventions were recommended to DOE by the National Institute for Standards and Technology, which screens all submitted inventions in terms of technical merit, potential for commercial success, and potential energy impact. By the end of 1990, at least 109 of these inventions had entered the market, generating total cumulative sales of more than $500 million. With $25.7 million in grants awarded from 1975 through 1990, and $63.1 million in program appropriations over the same period, ERIP has generated a 20:1 return in terms of sales values to grants, and an 8:1 return in sales versus program appropriations. It is estimated that 25% of all ERIP inventions had achieved sales by the end of 1990. While it is difficult to make exact comparisons between these percentages and other indicators of the success rates of technological innovations as a whole, the ERIP figures remain impressive. The commercial progress of spin-off technologies is also documented.

Performance of an Optimized Paper-Based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT in Fingerstick and Venipuncture Samples.

Directory of Open Access Journals (Sweden)

Sidhartha Jain

Full Text Available A paper-based, multiplexed, microfluidic assay has been developed to visually measure alanine aminotransferase (ALT in a fingerstick sample, generating rapid, semi-quantitative results. Prior studies indicated a need for improved accuracy; the device was subsequently optimized using an FDA-approved automated platform (Abaxis Piccolo Xpress as a comparator. Here, we evaluated the performance of the optimized paper test for measurement of ALT in fingerstick blood and serum, as compared to Abaxis and Roche/Hitachi platforms. To evaluate feasibility of remote results interpretation, we also compared reading cell phone camera images of completed tests to reading the device in real time.96 ambulatory patients with varied baseline ALT concentration underwent fingerstick testing using the paper device; cell phone images of completed devices were taken and texted to a blinded off-site reader. Venipuncture serum was obtained from 93/96 participants for routine clinical testing (Roche/Hitachi; subsequently, 88/93 serum samples were captured and applied to paper and Abaxis platforms. Paper test and reference standard results were compared by Bland-Altman analysis.For serum, there was excellent agreement between paper test and Abaxis results, with negligible bias (+4.5 U/L. Abaxis results were systematically 8.6% lower than Roche/Hitachi results. ALT values in fingerstick samples tested on paper were systematically lower than values in paired serum tested on paper (bias -23.6 U/L or Abaxis (bias -18.4 U/L; a correction factor was developed for the paper device to match fingerstick blood to serum. Visual reads of cell phone images closely matched reads made in real time (bias +5.5 U/L.The paper ALT test is highly accurate for serum testing, matching the reference method against which it was optimized better than the reference methods matched each other. A systematic difference exists between ALT values in fingerstick and paired serum samples, and can be

DUMAND-II progress report

International Nuclear Information System (INIS)

Wilkes, R.J.; Alexander, C.M.; Aoki, T.; Berson, U.; Bosetti, P.; Bolesta, J.; Boynton, P.E.; Bradner, H.; Camerini, U.; Dye, S.T.; Gergin, E.; Gorham, P.W.; Grieder, P.K.F.; Grogan, W.; Hanada, H.; Harris, D.; Hayashino, T.; Hazen, E.; Ito, M.; Jaworski, M.; Jenko, M.; Kawamoto, H.; Kitamura, T.; Kobayakawa, K.; Kondo, S.; Koske, P.; Learned, J.G.; Ley, C.; Lord, J.J.; Lord, R.; Lozic, T.; March, R.; Matsumoto, T.; Matsuno, S.; Mavretic, A.; McCourry, L.; Mignard, M.; Miller, K.; Minkowski, P.; Mitiguy, R.; Mitsui, K.; Narita, S.; Nicklaus, D.

1993-01-01

The design, scientific goals, and capabilities of the DUMAND II detector system are described. Construction was authorized by DOE in 1990, and construction of various detector subsystems is under way. Current plans include deployment of the shore cable, junction box and three strings of optical detector modules in 1993, with expansion to the full 9-string configuration about one year later

Beneficial uses program. Progress report ending December 31, 1978. [Irradiated sewage sludge

Energy Technology Data Exchange (ETDEWEB)

1979-03-01

The Beneficial Uses Program is a comprehensive program to develop the necessary technologies for cost-beneficial uses of existing and future surplus radioactive materials. The major portion of the work at Sandia is concentrated in two sub-programs: The Waste Resources Utilization Program and the Separation Technology and Source Development Program. Progress is reported on: (1) the Sandia Irradiator for Dried Sewage Sludge; (2) bacteriology; (3) mycology; (4) virology; (5) animal feeds containing irradiated sewage solids; (6) use of irradiated sewage sludge as fertilizer; and (7) development of /sup 90/Sr and /sup 137/Cs radiation sources obtained from radioactive wastes. (TFD)

Academic learning time in physical education (ALT-PE: is it related to fundamental movement skill acquisition and learning?. Tiempo de aprendizaje académico en educación física (ALT-PE: ¿tiene que ver con la adquisición y aprendizaje de habilidades motrices fundamentales?

Directory of Open Access Journals (Sweden)

Loza Olave, Edmundo

2007-01-01

Full Text Available AbstractIn this study, the relationship between time-variables of the physical education lesson and fundamental movement skill acquisition and learning was examined. One hundred and ten first grade students and their six physical educators participated. Students were pre-, post-, and re-tested both qualitatively and quantitatively on overhand throwing and catching. The Test of Gross Motor Development (Ulrich, 1985 was used for the assessment of qualitative skill performance and the Michigan Educational Assessment Program (MEAP, 1984 for the assessment of quantitative skill performance. Between pre- and post-tests students received an eight lessons unit instruction with emphasis on overhand throwing and catching. A total number of thirty-six students (6 students X 6 schools were selected, andtheir videotaped motor behavior in the lessons was analyzed with the Academic Learning Time ¿ Physical Education (ALT-PE,Parker, 1989. Regression analysis was applied to calculate students´ residual scores of achievement and to enable further data analysis. Correlation analysis between students´ achievement and ALT-PE categories indicated significant relationships between skill acquisition, learning and ALT-PE categories. It can be concluded that time devoted to practice skills, unlike times pent on activities irrelevant to the instructional task oron games, contributes to skill learning.ResumenEn este trabajo se estudia la relación entre variables temporales de las clases de Educación Física y la adquisición y aprendizaje de habilidades motrices fundamentales. En él participaron ciento diez alumnos de primer grado y seis profesores de Educación Física de Grecia. Los alumnos fueron examinados antes, durante y después tanto en términos cuantitativos como cualitativos en cuanto a lanzamientos y recepciones por encima de la cabeza. Se utilizó el Test de Desarrollo Motor Grueso (Ulrich, 1985 para evaluar el rendimiento en habilidades cualitativas y

Preparation, spectroscopic, thermal, antihepatotoxicity, hematological parameters and liver antioxidant capacity characterizations of Cd(II), Hg(II), and Pb(II) mononuclear complexes of paracetamol anti-inflammatory drug

Science.gov (United States)

El-Megharbel, Samy M.; Hamza, Reham Z.; Refat, Moamen S.

2014-10-01

Keeping in view that some metal complexes are found to be more potent than their parent drugs, therefore, our present paper aimed to synthesized Cd(II), Hg(II) and Pb(II) complexes of paracetamol (Para) anti-inflammatory drug. Paracetamol complexes with general formula [M(Para)2(H2O)2]·nH2O have been synthesized and characterized on the basis of elemental analysis, conductivity, IR and thermal (TG/DTG), 1H NMR, electronic spectral studies. The conductivity data of these complexes have non-electrolytic nature. Comparative antimicrobial (bacteria and fungi) behaviors and molecular weights of paracetamol with their complexes have been studied. In vivo the antihepatotoxicity effect and some liver function parameters levels (serum total protein, ALT, AST, and LDH) were measured. Hematological parameters and liver antioxidant capacities of both Para and their complexes were performed. The Cd2+ + Para complex was recorded amelioration of antioxidant capacities in liver homogenates compared to other Para complexes treated groups.

FERMILAB ACCELERATOR R&D PROGRAM TOWARDS INTENSITY FRONTIER ACCELERATORS : STATUS AND PROGRESS

Energy Technology Data Exchange (ETDEWEB)

Shiltsev, Vladimir [Fermilab

2016-11-15

The 2014 P5 report indicated the accelerator-based neutrino and rare decay physics research as a centrepiece of the US domestic HEP program at Fermilab. Operation, upgrade and development of the accelerators for the near- term and longer-term particle physics program at the Intensity Frontier face formidable challenges. Here we discuss key elements of the accelerator physics and technology R&D program toward future multi-MW proton accelerators and present its status and progress. INTENSITY FRONTIER ACCELERATORS

Proceedings of the first analysis meeting on JUPITER-II Program

Energy Technology Data Exchange (ETDEWEB)

Shiradata, Keisho; Yamamoto, Masaaki [comps.

1984-12-31

The JUPITER-II Program is the Joint Physics Large Heterogeneous Core Critical Experiments Program between the U.S. Department of Energy (US DOE) and PNC, Japan. The experiments began in May 1982 and ended in April 1984, as a part of the ZPPR-13 program. The ZPPR-13 is a series of critical assemblies designed to study the fundamental neutronic behavior of large, radially-heterogeneous LMFBR cores. This report describes the results of analysis of ZPPR-13A and preliminary analysis of ZPPR-13B, and some topics of recent activities in fast reactor physics.

Proceedings of the first analysis meeting on JUPITER-II Program

Energy Technology Data Exchange (ETDEWEB)

Shiradata, Keisho; Yamamoto, Masaaki [comps.

1985-12-31

The JUPITER-II Program is the Joint Physics Large Heterogeneous Core Critical Experiments Program between the U.S. Department of Energy (US DOE) and PNC, Japan. The experiments began in May 1982 and ended in April 1984, as a part of the ZPPR-13 program. The ZPPR-13 is a series of critical assemblies designed to study the fundamental neutronic behavior of large, radially-heterogeneous LMFBR cores. This report describes the results of analysis of ZPPR-13A and preliminary analysis of ZPPR-13B, and some topics of recent activities in fast reactor physics.

Progress in the pulsed power Inertial Confinement Fusion program

International Nuclear Information System (INIS)

Quintenz, J.P.; Matzen, M.K.; Mehlhorn, T.A.

1996-01-01

Pulsed power accelerators are being used in Inertial Confinement Fusion (ICF) research. In order to achieve our goal of a fusion yield in the range of 200 - 1000 MJ from radiation-driven fusion capsules, it is generally believed that ∼10 MJ of driver energy must be deposited within the ICF target in order to deposit ∼1 MJ of radiation energy in the fusion capsule. Pulsed power represents an efficient technology for producing both these energies and these radiation environments in the required short pulses (few tens of ns). Two possible approaches are being developed to utilize pulsed power accelerators in this effort: intense beams of light ions and z- pinches. This paper describes recent progress in both approaches. Over the past several years, experiments have successfully answered many questions critical to ion target design. Increasing the ion beam power and intensity are our next objectives. Last year, the Particle Beam Fusion Accelerator H (PBFA II) was modified to generate ion beams in a geometry that will be required for high yield applications. This 2048 modification has resulted in the production of the highest power ion beam to be accelerated from an extraction ion diode. We are also evaluating fast magnetically-driven implosions (z-pinches) as platforms for ICF ablator physics and EOS experiments. Z-pinch implosions driven by the 20 TW Saturn accelerator have efficiently produced high x- ray power (> 75 TW) and energy (> 400 kJ). Containing these x-ray sources within a hohlraum produces a unique large volume (> 6000 mm 3 ), long lived (>20 ns) radiation environment. In addition to studying fundamental ICF capsule physics, there are several concepts for driving ICF capsules with these x-ray sources. Progress in increasing the x-ray power on the Saturn accelerator and promise of further increases on the higher power PBFA II accelerator will be described

Seismic safety margin research program. Program plan, Revision II

International Nuclear Information System (INIS)

Smith, P.D.; Tokarz, F.J.; Bernreuter, D.L.; Cummings, G.E.; Chou, C.K.; Vagliente, V.N.; Johnson, J.J.; Dong, R.G.

1978-01-01

The document has been prepared pursuant to the second meeting of the Senior Research Review Group of the Seismic Safety Margin Research Program (SSMRP), which was held on June 15, 16, 1978. The major portion of the material contained in the document is descriptions of specific subtasks to be performed on the SSMRP. This is preceded by a brief discussion of the objective of the SSMRP and the approach to be used. Specific subtasks to be performed in Phase I of the SSMRP are as follows: (1) plant/site selection, (2) seismic input, (3) soil structure interaction, (4) structural building response, (5) structural sub-system response, (6) fragility, (7) system analysis, and (8) Phase II task definition

Rooftop PV system. Final technical progress report, Phase II

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-08-01

Under this four-year PV:BONUS Program, ECD and United Solar are developing and demonstrating two new lightweight flexible building integrated Photovoltaic (BIPV) modules specifically designed as exact replacements for conventional asphalt shingles and standing seam metal roofing. These modules can be economically and aesthetically integrated into new residential and commercial buildings, and address the even larger roofing replacement market. The modules are designed to be installed by roofing contractors without special training which minimizes the installation and balance of system costs. The modules will be fabricated from high-efficiency, multiple-junction a-Si alloy solar cells developed by ECD and United Solar. Under the Phase I Program, which ended in March 1994, we developed two different concept designs for rooftop PV modules: (1) the United Solar overlapping (asphalt shingle replacement) shingle-type modules and (2) the ECD metal roof-type modules. We also developed a plan for fabricating, testing and demonstrating these modules. Candidate demonstration sites for our rooftop PV modules were identified and preliminary engineering designs for these demonstrations were developed; a marketing study plan was also developed. The major objectives of the Phase II Program, which started in June 1994 was (1) to develop, test, and qualify these new rooftop modules; (2) to develop mechanical and electrical engineering specifications for the demonstration projects; and (3) to develop a marketing/commercialization plan.

Environmental Management Science Program awards. Fiscal year 1997 annual progress report

Energy Technology Data Exchange (ETDEWEB)

Simmons, A. [ed.; Benner, W.H.; DePaolo, D.J.; Faybishenko, B.; Majer, E.L.; Pallavicini, M.; Russo, R.E.; Shultz, P.G.; Wan, J.

1997-10-01

Lawrence Berkeley National Laboratory was awarded eight Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This report summarizes the progress of each grant in addressing significant DOE site cleanup issues after completion of the first year of research. The technical progress made to date in each of the research projects is described in greater detail in individual progress reports. The focus of the research projects covers a diversity of areas relevant to site cleanup, including bioremediation, health effects, characterization, and mixed waste. Some of the projects cut across a number of focus areas. Three of the projects are directed toward characterization and monitoring at the Idaho National Engineering and Environmental Laboratory, as a test case for application to other sites.

Environmental Management Science Program awards. Fiscal year 1997 annual progress report

International Nuclear Information System (INIS)

Simmons, A.; Benner, W.H.; DePaolo, D.J.; Faybishenko, B.; Majer, E.L.; Pallavicini, M.; Russo, R.E.; Shultz, P.G.; Wan, J.

1997-10-01

Lawrence Berkeley National Laboratory was awarded eight Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This report summarizes the progress of each grant in addressing significant DOE site cleanup issues after completion of the first year of research. The technical progress made to date in each of the research projects is described in greater detail in individual progress reports. The focus of the research projects covers a diversity of areas relevant to site cleanup, including bioremediation, health effects, characterization, and mixed waste. Some of the projects cut across a number of focus areas. Three of the projects are directed toward characterization and monitoring at the Idaho National Engineering and Environmental Laboratory, as a test case for application to other sites

The RERTR [Reduced Enrichment Research and Test Reactor] Program: Progress and plans

International Nuclear Information System (INIS)

Travelli, A.

1987-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1986, the activities, results, and new developments which occurred in 1987 are reviewed. Irradiation of the second miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was completed and postirradiation examinations were performed on many of its miniplates. The whole-core ORR demonstration with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 was completed at the end of March with excellent results and with 29 elements estimated to have reached at least 40% average burnup. Good progress was made in the area of LEU usage for the production of fission 99 Mo, and in the coordination of safety evaluations related to LEU conversions of US university reactors. Planned activities include testing and demonstrating advanced fuels intended to allow use of reduced enrichment uranium in very-high-performance reactors. Two candidate fuels are U 3 Si-Al with 19.75% enrichment and U 3 Si 2 -Al with 45% enrichment. Demonstration of these fuels will include irradiation of full-size elements and, possibly, a full-core demonstration. Achievement of the final program goals is still projected for 1990. This progress could not have been possible without the close international cooperation which has existed from the beginning, and which is essential to the ultimate success of the RERTR Program

The status of the RERTR Program: Overview, progress and plans

International Nuclear Information System (INIS)

Travelli, A.

1985-01-01

The status of the U.S. Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U 3 Si 2 -AI and U 3 Si-AI fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U 3 Si 2 -AI fuel at 4.8 g U/cm 3 . Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U 3 Si-AI fuel with ∼7 g U/cm 3 is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals. (author)

Preparation of a Sepia Melanin and Poly(ethylene-alt-maleic Anhydride Hybrid Material as an Adsorbent for Water Purification

Directory of Open Access Journals (Sweden)

Guido Panzarasa

2018-01-01

Full Text Available Meeting the increasing demand of clean water requires the development of novel efficient adsorbent materials for the removal of organic pollutants. In this context the use of natural, renewable sources is of special relevance and sepia melanin, thanks to its ability to bind a variety of organic and inorganic species, has already attracted interest for water purification. Here we describe the synthesis of a material obtained by the combination of sepia melanin and poly(ethylene-alt-maleic anhydride (P(E-alt-MA. Compared to sepia melanin, the resulting hybrid displays a high and fast adsorption efficiency towards methylene blue (a common industrial dye for a wide pH range (from pH 2 to 12 and under high ionic strength conditions. It is easily recovered after use and can be reused up to three times. Given the wide availability of sepia melanin and P(E-alt-MA, the synthesis of our hybrid is simple and affordable, making it suitable for industrial water purification purposes.

Effects of Nordic Walking and Pilates training programs on aminotransferase activity in overweight and obese elderly women

Directory of Open Access Journals (Sweden)

Magdalena Hagner-Derengowska

2015-12-01

3 Chair of Vascular and Internal Diseases, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Poland     Corresponding author: Magdalena Hagner-Derengowska, PT, PhD Chair of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń M. Skłodowskiej-Curie 9 Street, 85-094 Bydgoszcz, Poland E-mail address: m_hagner-derengowska@wp.pl     ABSTRACT Background & Aims: Elevation of alanine (ALT and aspartate aminotransferase (AST activities may appear as liver injury due to fat storage and other enzyme sources, such as rhabdomyolysis. Elevated ALT is associated with all-cause and cardiovascular mortality in an elderly population. The aims of this study was to determine the effect of a 10-weeks training program on the serum activity of these enzymes in postmenopausal women with overweight and obesity. Methods: The study comprised 81 postmenopausal women with overweight and obesity: 34 (42% of whom completed a 10-weeks Nordic Walking (NW rehabilitation program, 27 (33% of whom completed a Pilates rehabilitation program, and 20 (25% of whom were the control group. Blood for testing for ALT, AST, and other parameters of metabolic syndrome was collected before the program commenced and after it finished. Results: Elevated (> 34 U/l ALT and AST activities presented in 9 (11% and 7 (9% of the patients, respectively. A reduction in ALT and AST activities was observed in 43 (53% of the subjects, and in 61%, 59% and 40%, and 47%, 63% and 50% of the individuals who completed the NW and Pilates programs and were in the control group, respectively. Conclusions: The outcome of the training programs on aminotransferase serum activities in postmenopausal women with overweight and obesity was individually different and not related to exercise type.   Keywords: alanine aminotransferase, aspartate aminotransferase, obesity, Nordic Walking, Pilates.

Progress and problems in the Formerly Utilized Sites Remedial Action Program and Surplus Facilities Management Program

International Nuclear Information System (INIS)

Fiore, J.J.; Turi, G.P.

1988-01-01

The Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to identify, evaluate, and as appropriate, conduct remedial actions at sites used in the early years of nuclear energy development by the Manhattan Engineer District and the Atomic Energy Commission (AEC). This program currently has 29 sites and is evaluating 350 other sites for possible inclusion in the program. Another remedial action program in the Department of Energy's (DOE) Division of Facility and Site Decommissioning Projects is the Surplus Facilities Management Program (SFMP). The SFMP involves the safe management, decontamination and disposal of surplus DOE contaminated facilities which were not related to defense activities. There are currently 33 projects at 15 different sites in the program. These two programs have made steady progress over the last 10 or so years in cleaning up sites so that they can be reused or released for unrestricted use. Work has been completed at 8 of the FUSRAP sites and three of the SFMP sites

Aging and Surveillance Program MINUTEMAN II/III Stage II Program Progress

Science.gov (United States)

1986-05-01

CW C; C;f: C E " 0 o Wo - . acca w. cr. 0: - w- Lu .1 -t 𔃻.1 4 ’S < ’SI--T 0 X I m mu ( m a0 mammm mommu 0 w 04 00 000000 im0LZo0000c 0 000C1000400 0...FRAC IW 2850 K. S-. 85B 0.0 1.0572 0.171 1.040 t389 0.2 1.0692 0.064 0.155 1.012 :’ f6 0.2 0.9936 0.060 0.154 1.027 0 0.3 1.0108 0.061 0.151 1.013 0.5

Alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom promotes positive inotropism and chronotropism in fish heart.

Science.gov (United States)

Monteiro, D A; Kalinin, A L; Selistre-de-Araujo, H S; Vasconcelos, E S; Rantin, F T

2016-02-01

Alternagin-C (ALT-C) is a disintegrin-like protein purified from the venom of the snake, Rhinocerophis alternatus. Recent studies showed that ALT-C is able to induce vascular endothelial growth factor (VEGF) expression, endothelial cell proliferation and migration, angiogenesis and to increase myoblast viability. This peptide, therefore, can play a crucial role in tissue regeneration mechanisms. The aim of this study was to evaluate the effects of a single dose of alternagin-C (0.5 mg kg(-1), via intra-arterial) on in vitro cardiac function of the freshwater fish traíra, Hoplias malabaricus, after 7 days. ALT-C treatment increased the cardiac performance promoting: 1) significant increases in the contraction force and in the rates of contraction and relaxation with concomitant decreases in the values of time to the peak tension and time to half- and 90% relaxation; 2) improvement in the cardiac pumping capacity and maximal electrical stimulation frequency, shifting the optimum frequency curve upward and to the right; 3) increases in myocardial VEGF levels and expression of key Ca(2+)-cycling proteins such as SERCA (sarcoplasmic reticulum Ca(2+)-ATPase), PLB (phospholamban), and NCX (Na(+)/Ca(2+) exchanger); 4) abolishment of the typical negative force-frequency relationship of fish myocardium. In conclusion, this study indicates that ALT-C improves cardiac function, by increasing Ca(2+) handling efficiency leading to a positive inotropism and chronotropism. The results suggest that ALT-C may lead to better cardiac output regulation indicating its potential application in therapies for cardiac contractile dysfunction. Copyright © 2015 Elsevier Ltd. All rights reserved.

Baseline gas turbine development program. Eighteenth quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Schmidt, F W; Wagner, C E [comps.

1977-04-30

Progress is reported for a program whose goals are to demonstrate an experimental upgraded gas turbine powered automobile which meets the 1978 Federal Emissions Standards, has significantly improved fuel economy, and is competitive in performance, reliability, and potential manufacturing cost with the conventional piston engine powered, compact-size American automobile. Initial running of the upgraded engine took place on July 13, 1976. The engine proved to be mechanically sound, but was also 43% deficient in power. A continuing corrective development effort has to date reduced the power deficiency to 32%. Compressor efficiency was increased 2 points by changing to a 28-channel diffuser and tandem deswirl vanes; improved processing of seals has reduced regenerator leakage from about 5 to 2.5% of engine flow; a new compressor turbine nozzle has increased compressor turbine stage efficiency by about 1 point; and adjustments to burner mixing ports has reduced pressure drop from 2.8 to 2.1% of engine pressure. Key compressor turbine component improvements are scheduled for test during the next quarterly period. During the quarter, progress was also made on development of the Upgraded Vehicle control system; and instrumentation of the fourth program engine was completed by NASA. The engine will be used for development efforts at NASA LeRC.

Transuranic solid waste management programs. Progress report, July--December 1975

International Nuclear Information System (INIS)

1976-09-01

Progress is reported for three transuranic solid waste management programs funded at the Los Alamos Scientific Laboratory (LASL) by the Energy Research and Development Administration (ERDA) Division of Fuel Cycle and Production (NFCP). Under the Transuranic Waste Research and Development Program, continued studies have shown the potential attractiveness of fiber drums as an acceptable substitute for the current mild steel storage containers. Various fire retardants have been evaluated, with one indicating significant ability to inhibit fire propagation. Continued radiolysis studies, under laboratory and field conditions, continue to reaffirm earlier LASL results indicating no significant hazard from radiolytic reactions, assuming no change in current allowable loadings. Care must be exercised to differentiate between radiolytic and chemical reactions. Other efforts have identified a modification of chemical processing to reduce the amounts of plutonium requiring retrievable storage. Studies are also in progress to enhance the sensitivity of the LASL MEGAS assay system. The Transuranic-Contaminated Solid Waste Treatment Development Facility building was 72 percent complete as of December 31, 1975, which is in accord with the existing schedule. Procurement of process components is also on schedule. Certain modifications to the facility have been made, and various pre-facility experiments on waste container handling and processing have been completed. The program for the Evaluation of Transuranic-Contaminated Radioactive Waste Disposal Areas continued development of various computer modules for simulation of radionuclide transport within the biosphere. In addition, program staff contributed to an ERDA document on radioactive waste management through the preparation of a report on burial of radioactive waste at ERDA-contractor and commercial sites

Transuranic Solid Waste Management Programs. Progress report, July--December 1974

International Nuclear Information System (INIS)

1975-10-01

Progress is reported for three transuranic solid waste management programs funded at the Los Alamos Scientific Laboratory by the Energy Research and Development Administration Division of Waste Management and Transportation. Under the Transuranic Waste Research and Development Program, a completed evaluation of stainless steel drums showed that although the material has superior corrosion-resistant properties, its higher cost makes a thorough investigation of other container systems mandatory. A program to investigate more economical, nonmetallic containers is proposed. Preliminary fire tests in mild steel drums have been completed with fire propagation not appearing to be a problem unless container integrity is lost. Investigation of the corrosion of mild steel drums and the evaluation of potential corrosion inhibitors, in a variety of humid environments, continues. Experimental results of both laboratory and field investigations on radiolysis of transuranic elements in hydrogenous waste are discussed. Progress in the development of instrumentation for monitoring and segregating low-level wastes is described. New plans and developments for the Transuranic-Contaminated Solid Waste Treatment Development Facility are presented. The current focus is on a comparison of all alternative waste reduction systems toward a relative Figure of Merit with universal application. Drawings, flowsheets, and building layouts are included, and the proposed incinerator device is detailed. The release mechanisms, inter- and intraregional transport mechanisms, and exhumation studies relevant to the Evaluation of Transuranic-Contaminated Radioactive Waste Disposal Areas Program are defined and analyzed. A detailed description is given of the formulation of the computer simulation scheme for the intraregional biological transport model

Transuranic solid waste management programs. Progress report, July--December 1975

Energy Technology Data Exchange (ETDEWEB)

1976-09-01

Progress is reported for three transuranic solid waste management programs funded at the Los Alamos Scientific Laboratory (LASL) by the Energy Research and Development Administration (ERDA) Division of Fuel Cycle and Production (NFCP). Under the Transuranic Waste Research and Development Program, continued studies have shown the potential attractiveness of fiber drums as an acceptable substitute for the current mild steel storage containers. Various fire retardants have been evaluated, with one indicating significant ability to inhibit fire propagation. Continued radiolysis studies, under laboratory and field conditions, continue to reaffirm earlier LASL results indicating no significant hazard from radiolytic reactions, assuming no change in current allowable loadings. Care must be exercised to differentiate between radiolytic and chemical reactions. Other efforts have identified a modification of chemical processing to reduce the amounts of plutonium requiring retrievable storage. Studies are also in progress to enhance the sensitivity of the LASL MEGAS assay system. The Transuranic-Contaminated Solid Waste Treatment Development Facility building was 72 percent complete as of December 31, 1975, which is in accord with the existing schedule. Procurement of process components is also on schedule. Certain modifications to the facility have been made, and various pre-facility experiments on waste container handling and processing have been completed. The program for the Evaluation of Transuranic-Contaminated Radioactive Waste Disposal Areas continued development of various computer modules for simulation of radionuclide transport within the biosphere. In addition, program staff contributed to an ERDA document on radioactive waste management through the preparation of a report on burial of radioactive waste at ERDA-contractor and commercial sites.

"Almha La Vengadora": Protagonista del indigenismo de neovanguardia alteño

Directory of Open Access Journals (Sweden)

Maria Irina Soto-Mejia

2016-03-01

Este artículo discute la obra de Crispín Portugal (1976-2007, un escritor alteño, en el contexto de la lucha contra la pobreza y el racismo que enfrentan a las ciudades de El Alto y La Paz, y del movimiento en contra del mercado  que comenzó en Argentina produciendo libros con tapas de cartón compradas a los cartoneros. Portugal y otros escritores indígenas iniciaron un proyecto editorial llamado Yerba Mala Cartonera, que cuenta con su propio blog, para diseminar la literatura boliviana que no cuenta con otros medios de difusión. A través de la revisión de un cuento de Portugal (Almha La Vengadora que describe a una chola luchadora de El Alto cuyo nombre en el cuadrilátero es “la vengadora”, este trabajo plantea la configuración de un indigenismo alteño de neovanguardia equiparable al vanguardismo de Gamaliel Churata.  Con este propósito, presta especial atención a El Alto –la ciudad indígena más grande de Latinoamérica- situándolo como escenario clave para el desarrollo de una neovanguardia que se alimenta del neoliberalismo fallido para configurar una propuesta de modernidad que recupera el pasado indígena aymara para inventar otras formas de futuro.

New imaging systems in nuclear medicine. Technical progress report, October 1, 1976--May 31, 1977

International Nuclear Information System (INIS)

Brownell, G.L.

1977-01-01

Work carried out on the development of instrumentation and techniques for positron scintigraphy is discussed. Progress in positron imaging instrumentation and applications is detailed. The assembly and initial evaluation of the new multicrystal positron camera, PC-II, has been completed. Images have been obtained in both two and three-dimensions which demonstrate the basic physical properties of the instrument. Successful measurements using transverse section imaging have been carried out on animals and human volunteers. Physiological investigation using PC-II is proceeding. A flexible and accurate computer program has been developed for transverse section reconstruction of data acquired by PC-II. This program makes it possible to reconstruct both the activity distribution and the distribution of absorption. The program has been developed in such a way that it can handle variations in the data collection procedure. Clinical studies using PC-I and PC-II are being carried on in areas of heart, lung and brain

A summary of the program and progress to 1984 December of the Canadian nuclear fuel waste management program

International Nuclear Information System (INIS)

Dixon, R.S.

1986-08-01

The Canadian Nuclear Fuel Waste Management Program involves research into the storage and transportation of used nuclear fuel, immobilization of fuel waste, and deep geological disposal of the immobilized waste. The program is now in the fifth year of a ten-year generic research and development phase. The objective of this phase of the program is to assess the safety and environmental aspects of the deep underground disposal of immobilized fuel waste in plutonic rock. The objectives of the research for each component of the program and the progress made to the end of 1984 are described in this report. 74 refs

Progress in Childhood Vaccination Data in Immunization Information Systems - United States, 2013-2016.

Science.gov (United States)

Murthy, Neil; Rodgers, Loren; Pabst, Laura; Fiebelkorn, Amy Parker; Ng, Terence

2017-11-03

In 2016, 55 jurisdictions in 49 states and six cities in the United States* used immunization information systems (IISs) to collect and manage immunization data and support vaccination providers and immunization programs. To monitor progress toward achieving IIS program goals, CDC surveys jurisdictions through an annual self-administered IIS Annual Report (IISAR). Data from the 2013-2016 IISARs were analyzed to assess progress made in four priority areas: 1) data completeness, 2) bidirectional exchange of data with electronic health record systems, 3) clinical decision support for immunizations, and 4) ability to generate childhood vaccination coverage estimates. IIS participation among children aged 4 months through 5 years increased from 90% in 2013 to 94% in 2016, and 33 jurisdictions reported ≥95% of children aged 4 months through 5 years participating in their IIS in 2016. Bidirectional messaging capacity in IISs increased from 25 jurisdictions in 2013 to 37 in 2016. In 2016, nearly all jurisdictions (52 of 55) could provide automated provider-level coverage reports, and 32 jurisdictions reported that their IISs could send vaccine forecasts to providers via Health Level 7 (HL7) messaging, up from 17 in 2013. Incremental progress was made in each area since 2013, but continued effort is needed to implement these critical functionalities among all IISs. Success in these priority areas, as defined by the IIS Functional Standards (1), bolsters clinicians' and public health practitioners' ability to attain high vaccination coverage in pediatric populations, and prepares IISs to develop more advanced functionalities to support state/local immunization services. Success in these priority areas also supports the achievement of federal immunization objectives, including the use of IISs as supplemental sampling frames for vaccination coverage surveys like the National Immunization Survey (NIS)-Child, reducing data collection costs, and supporting increased precision

Fukushima Daiichi Unit 1 Uncertainty Analysis-Exploration of Core Melt Progression Uncertain Parameters-Volume II.

Energy Technology Data Exchange (ETDEWEB)

Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brooks, Dusty Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-08-01

Sandia National Laboratories (SNL) has conducted an uncertainty analysi s (UA) on the Fukushima Daiichi unit (1F1) accident progression wit h the MELCOR code. Volume I of the 1F1 UA discusses the physical modeling details and time history results of the UA. Volume II of the 1F1 UA discusses the statistical viewpoint. The model used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). The goal of this work was to perform a focused evaluation of uncertainty in core damage progression behavior and its effect on key figures - of - merit (e.g., hydrogen production, fraction of intact fuel, vessel lower head failure) and in doing so assess the applicability of traditional sensitivity analysis techniques .

A phase II trial with bevacizumab and irinotecan for patients with primary brain tumors and progression after standard therapy

DEFF Research Database (Denmark)

Møller, Søren; Grunnet, Kirsten; Hansen, Steinbjørn

2012-01-01

The combination of irinotecan and bevacizumab has shown efficacy in the treatment of recurrent glioblastoma multiforme (GBM). A prospective, phase II study of 85 patients with various recurrent brain tumors was carried out. Primary endpoints were progression free survival (PFS) and response rate....

Energy extension service pilot program evaluation report: the first year. Volume II: pilot state reports

Energy Technology Data Exchange (ETDEWEB)

1979-09-01

Volume II of the Energy Extension Service Evaluation presents a discussion of the operations of the ten EES pilot-state programs during the period from October 1, 1977 through September 30, 1978. Each of the ten pilot states - Alabama, Connecticut, Michigan, New Mexico, Pennsylvania, Tennessee, Texas, Washington, Wisconsin, and Wyoming - received a grant of approximately $1.1 million to develop and implement a 19-month program beginning on October 1, 1977. Volume II provides a case-study description of the operations of the pilot program in each state, with special attention given to the two programs selected in each state for more detailed study and survey research. Some survey data and analysis are presented for the emphasis programs.

Geothermal drilling and completion technology development program. Quarterly progress report, January-March 1980

Energy Technology Data Exchange (ETDEWEB)

Varnado, S.G. (ed.)

1980-04-01

The progress, status, and results of ongoing Research and Development (R and D) within the Geothermal Drilling and Completion Technology Development Program are described. The program emphasizes the development of geothermal drilling hardware, drilling fluids, completion technology, and lost circulation control methods. Advanced drilling systems are also under development. The goals of the program are to develop the technology required to reduce well costs by 25% by 1983 and by 50% by 1987.

Impact of a community based implementation of REACH II program for caregivers of Alzheimer's patients.

Directory of Open Access Journals (Sweden)

Kristine Lykens

Full Text Available BACKGROUND: In 2009 an estimated 5.3 million people in the United States were afflicted with Alzheimer's disease, a degenerative form of dementia. The impact of this disease is not limited to the patient but also has significant impact on the lives and health of their family caregivers. The Resources for Enhancing Alzheimer's Caregiver Health (REACH II program was developed and tested in clinical studies. The REACH II program is now being delivered by community agencies in several locations. This study examines the impact of the REACH II program on caregiver lives and health in a city in north Texas. STUDY DESIGN: Family caregivers of Alzheimer's patients were assessed using an instrument covering the multi-item domains of Caregiver Burden, Depression, Self-Care, and Social Support upon enrollment in the program and at the completion of the 6 month intervention. The domain scores were analyzed using a multivariate paired t-test and Bonferroni confidence interval for the differences in pre- and post-service domain scores. RESULTS: A total of 494 families were enrolled in the program during the period January 1, 2011 through June 30, 2012. Of these families 177 completed the 6 month program and have pre - and post service domain scores. The median age for the caregivers was 62 years. The domain scores for Depression and Caregiver Burden demonstrated statistically significant improvements upon program completion. CONCLUSION: The REACH II intervention was successfully implemented by a community agency with comparable impacts to those of the clinical trial warranting wider scale implementation.

progressive problemshifts between different research programs in science education: A lakatosian perspective

Science.gov (United States)

Niaz, Mansoor

Given the importance of epistemology and philosophy of science, the Lakatos (1970) methodology is particularly suited to evaluate competing research programs in science education. This article has two objectives: (a) to evaluate critically the interpretations of Gilbert and Swift (1985) and Rowell and Dawson (1989), and (b) to postulate a progressive problemshift between Piaget's epistemic subject and Pascual-Leone's metasubject. Regarding the Gilbert and Swift interpretation, it is concluded that the alternative conceptions movement at its present stage of development cannot explain the previous success of its rival (Piagetian school) nor supersede it by a further display of heuristic power as required by Lakatos. If we accept the Rowell and Dawson thesis it would amount to the postulation of Piagetian and integrated (Piagetian and schema) theories as rival research programs. It appears that the Rowell and Dawson approach would enrich Piagetian theory with descriptive content rather than explanatory constructs, and thus would not lead to a progressive problemshift. It is concluded that Pascual-Leone's theory extends Piaget's negative heuristic by introducing antecedent variables, and at the same time enriches the positive heuristic by introducing metasubjective task analysis, which leads to a progressive problemshift.

AR and TD Fossil Energy Materials Program. Quarterly progress report for the period ending December 31, 1981

Energy Technology Data Exchange (ETDEWEB)

1982-04-01

The ORNL Fossil Energy Materials Program Office compiles and issues this combined quarterly progress report from camera-ready copies submitted by each of the participating subcontractor organizations. This report of activities on the program is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FY 1982-1986 in which projects are organized according to fossil energy technologies. This report is divided into parts and chapters with each part describing projects related to a particular fossil energy technology. Chapters within a part provide details of the various projects associated with that technology. We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program. Plans for the program will be issued annually. A draft of the program plan for FY 1982 to 1986 has been prepared and is in the review process. The implementation of these plans will be reflected by these quarterly progress reports, and this dissemination of information will bw augmented by topical or final reports as appropriate.

Beneficial Uses Program. Progress report, period ending December 31, 1977. [Irradiated sewage sludge

Energy Technology Data Exchange (ETDEWEB)

1978-11-01

The Beneficial Uses Program is a comprehensive program to develop the necessary technologies for cost-beneficial uses of existing and future surplus radioactive materials. The major portion of the work at Sandia is concentrated in two sub-programs: the Waste Resources Utilization Program and the Separation Technology and Source Development Program. Progress is reported on: (1) the Sandia Irradiator for Dried Sewage Solids; (2) bacteriology; (3) mycology; (4) virology; (5) animal feeds containing irradiated sewage solids; (6) use of irradiated sewage sludge as fertilizer; and (7) development of /sup 90/Sr and /sup 137/Cs radiation sources obtained from radioactive wastes. (TFD)

Beneficial Uses Program. Progress report, period ending March 31, 1979. [Irradiated sewage sludge

Energy Technology Data Exchange (ETDEWEB)

1979-08-01

The Beneficial Uses Program is a comprehensive program to develop the necessary technologies for cost-beneficial uses of existing and future surplus radioactive materials. The major portion of the work at Sandia is concentrated in two sub-programs: the Waste Resources Utilization Program and the Separation Technology and Source Development Program. Progress is reported on: (1) the Sandia Irradiator for Dried Sewage Solids; (2) bacteriology; (3) mycology; (4) virology; (5) animal feeds containing irradiated sewage solids; (6) use of irradiated sewage sludge as fertilizer; and (7) development of /sup 137/Cs radiation sources obtained from radioactive wastes. (TFD)

Operational reliability testing of FBR fuel in EBR-II

International Nuclear Information System (INIS)

Asaga, Takeo; Ukai, Shigeharu; Nomura, Shigeo; Shikakura, Sakae

1991-01-01

The operational reliability testing of FBR fuel has been conducting in EBR-II as a DOE/PNC collaboration program. This paper reviews the achieved summary of Phase-I test as well as outline of progressing Phase-II test. In Phase-I test, the reliability of FBR fuel pins including 'MONJU' fuel was demonstrated at the event of operational transient. Continued operation of the failed pins was also shown to be feasible without affecting the plant operation. The objectives of the Phase-II test is to extend the data base relating with the operational reliability for long life fuel, and to supply the highly quantitative evaluation. The valuable insight obtained in Phase-II test are considerably expected to be useful toward the achievement of commercial FBR. (author)

Accelerator technology program. Progress report, January-December 1979

Energy Technology Data Exchange (ETDEWEB)

Knapp, E.A.; Jameson, R.A. (comps.)

1980-11-01

The activities of Los Alamos Scientific Laboratory's (LASL) Accelerator Technology (AT) Division during the calendar year 1979 are highlighted, with references to more detailed reports. This report is organized around the major projects of the Division, reflecting a wide variety of applications and sponsors. The first section covers the Fusion Materials Irradiation Test program, a collaborative effort with the Hanford Engineering Development Laboratory; the second section summarizes progress on the Proton Storage Ring to be built between LAMPF and the LASL Pulsed Neutron Research facility. A new project that achieved considerable momentum during the year is described next - the free-electron laser studies; the following section discusses the status of the Pion Generator for Medical Irradiation program. Next, two more new programs, the racetrack microtron being developed jointly by AT-Division and the National Bureau of Standards and the radio-frequency (rf) accelerator development for heavy ion fusion, are outlined. Development activities on a new type of high-power, high-efficiency rf amplifier called the gyrocon are then reported, and the final sections cover development of H/sup -/ ion sources and injectors, and linear accelerator instrumentation and beam dynamics.

Clinical Investigation Program: Annual Progress Report

Science.gov (United States)

1992-09-30

Diamminedichloroplatinum (II), Methotrexate and Bleomycin in the Treatment of Advanced Epidermoid Carcinoma of the Penis , Phase II...II), Methotrexate and Bleomycin in the Treatment of Advanced Epidermoid Carcinoma of the Penis , Phase II (5) Start Date: (6) Est Compl Date: (7...Associate Investigators (11) Key Words: constitutional delay delayed puberty (12) Accumulative MEDCASE:* (13) Est Accum OKA Cost:* *Refer to Unit Summary

Antimicrobial Exposure Assessment Task Force II (AEATF II) Volume 5: Governing Document for a Multi-Year Antimicrobial Chemical Exposure Monitoring Program (interim draft document)

Science.gov (United States)

Describes the overall scope of the AEATF II program, demonstrates the need for additional human exposure monitoring data and explains the proposed methodology for the exposure monitoring studies proposed for conduct by the AEATF II.

Geothermal Energy R&D Program Annual Progress Report Fiscal Year 1993

Energy Technology Data Exchange (ETDEWEB)

None

1994-04-01

In this report, the DOE Geothermal Program activities were split between Core Research and Industrial Development. The technical areas covered are: Exploration Technology, Drilling Technology, Reservoir Technology (including Hot Dry Rock Research and The Geyser Cooperation), and Conversion Technology (power plants, materials, and direct use/direct heat). Work to design the Lake County effluent pipeline to help recharge The Geysers shows up here for the first time. This Progress Report is another of the documents that are reasonable starting points in understanding many of the details of the DOE Geothermal Program. (DJE 2005)

Seasonal immigrant workers and programs in UK, France, Spain and Italy

NARCIS (Netherlands)

López-Sala, A.; Molinero Gerbeau, Y.; Eremenko, T.; Beauchemin, C.; Samuk, S.; Consterdine, E.

2016-01-01

Programmes aimed at channelling seasonal workers to the labour market of European countries have a long tradition. Many of them started in the decades following World War II, but have changed a great deal over time, alt hough the majority are aimed seasonal economic sectors, such as agriculture or

US/Japan collaborative program on fusion reactor materials: Summary of the tenth DOE/JAERI Annex I technical progress meeting on neutron irradiation effects in first wall and blanket structural materials

International Nuclear Information System (INIS)

Rowcliffe, A.F.

1989-01-01

This meeting was held at Oak Ridge National Laboratory on March 17, 1989, to review the technical progress on the collaborative DOE/JAERI program on fusion reactor materials. The purpose of the program is to determine the effects of neutron irradiation on the mechanical behavior and dimensional stability of US and Japanese austenitic stainless steels. Phase I of the program focused on the effects of high concentrations of helium on the tensile, fatigue, and swelling properties of both US and Japanese alloys. In Phase II of the program, spectral and isotropic tailoring techniques are fully utilized to reproduce the helium:dpa ratio typical of the fusion environment. The Phase II program hinges on a restart of the High Flux Isotope Reactor by mid-1989. Eight target position capsules and two RB* position capsules have been assembled. The target capsule experiments will address issues relating to the performance of austenitic steels at high damage levels including an assessment of the performance of a variety of weld materials. The RB* capsules will provide a unique and important set of data on the behavior of austenitic steels irradiated under conditions which reproduce the damage rate, dose, temperature, and helium generation rate expected in the first wall and blanket structure of the International Thermonuclear Experimental Reactor

38 CFR 21.9700 - Yellow Ribbon Program.

Science.gov (United States)

2010-07-01

... Yellow Ribbon Program and the student maintains satisfactory progress, conduct, and attendance according...) Based on student status (i.e. , undergraduate, graduate, doctoral), or (ii) For each subelement of the institution (i.e., college or professional school). The maximum amount specified for each subelement of the...

Progress of the RERTR [Reduced Enrichment Research and Test Reactor] Program in 1989

International Nuclear Information System (INIS)

Travelli, A.

1989-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1988, the major events, findings, and activities of 1989 are reviewed. The scope of the RERTR Program activities was curtailed, in 1989, by an unexpected legislative restriction which limited the ability of the Arms Control and Disarmament Agency to adequately fund the program. Nevertheless, the thrust of the major planned program activities was maintained, and meaningful results were obtained in several areas of great significance for future work. 15 refs., 12 figs

Implementasi Program Pembinaan Napi di Lapas Kelas II B Metro

Directory of Open Access Journals (Sweden)

Narsidi Narsidi

2004-01-01

Full Text Available Penelitian ini bertujuan untuk mengungkap kesiapan sarana fisik dan nonfisik, jenis program pembinaan yang dilaksanakan, proses pelaksanaan program pembinaan, hasil, dan kemanfaatan program bagi narapidana di Lapas. Penelitian ini adalah jenis penelitian studi kasus dengan pendekatan kualitatif fenomenologis naturalistik. Pengumpulan data dilakukan melalui teknik observasi dan wawancara Teknik analisis data menggunakan model analisis interaktif dari Miles dan Huberman (1984. Hasil analisis data menunjukkan, bahwa Lapas Kelas II B Metro secara nonfisik masih memiliki kekurangan, baik kuantitas maupun kualitas. Proses pembinaan narapidana di Lapas belum banyak mengadopsi teori pembelajaran orang dewasa sehingga model pembelajarannya masih cenderung menggunakan model pembelajaran anak-anak (paedagogik. Secara umum dapat dikatakan bahwa pembinaan yang dilakukan Lapas dirasakan kemanfaatannya oleh narapidana.Namun, pembinaan yang dilakukan belum dapat memenuhi minat dan kebutuhan narapidana. Kata kunci: implementasi, program, pembinaan, narapidana.

Ultrasonic flowmeters. Progress report II

International Nuclear Information System (INIS)

Wittekind, W.D.

1980-01-01

This progress report presents results of in-plant testing of the prototype ultrasonic flowmeter and describes modifications to the prototype as a result of these tests. The modified prototype, designated MOD-I, is described in detail including the principle of operation, equipment used and the results of both laboratory and in-plant demonstrations

High Energy Physics Group. Annual progress report, fiscal year 1983

International Nuclear Information System (INIS)

1983-01-01

Perhaps the most significant progress during the past twelve months of the Hawaii experimental program, aside from publication of results of earlier work, has been the favorable outcome of several important proposals in which a substantial fraction of our group is involved: the Mark II detector as first-up at the SLC, and DUMAND's Stage I approval, both by DOE review panels. When added to Fermilab approval of two neutrino bubble-chamber experiments at the Tevatron, E632 and E646, the major part of the Hawaii experimental program for the next few years is now well determined. Noteworthy in the SLAC/SLC/Mark II effort is the progress made in developing silicon microstrip detectors with microchip readout. Results from the IMB(H) proton decay experiment at the Morton Salt Mine, although not detecting proton decay, set the best lower limit on the proton's lifetime. Similarly the Very High Energy Gamma Ray project is closely linked with DUMAND, at least in principle, since these gammas are expected to arise from pi-zero decay, while the neutrinos come from charged meson decay. Some signal has been seen from Cygnus X-3, and other candidates are being explored. Preparations for upgrading the Fermilab 15' Bubble Chamber have made substantial progress. Sections of the Progress Report are devoted to VAX computer system improvements, other hardware and software improvements, travel in support of physics experiments, publications and other public reports, and last analysis of data still being gleaned from experimental data taken in years past (PEP-14 and E546, E388). High energy physics theoretical research is briefly described

Progress report on reactor physics research program, January 1963 - February 1964

Energy Technology Data Exchange (ETDEWEB)

NONE

1964-02-15

This progress report is a part of the annual report of the department of reactor physics prepared for the Boris Kidric Institute of nuclear sciences. It is a review of research activities in the field of theoretical and experimental reactor physics in the year 1973. A part of this program was included in the NPY Cooperative program in reactor physics. The topics covered by this report are as follows: Calculations of the thermal neutron distribution and reaction rate in a reactor cell and comparison with experiments; buckling measurements; thermalization and slowing down of neutrons; pulsed neutron source techniques; and reactor kinetics.

Progress report on reactor physics research program, January 1963 - February 1964

International Nuclear Information System (INIS)

1964-02-01

This progress report is a part of the annual report of the department of reactor physics prepared for the Boris Kidric Institute of nuclear sciences. It is a review of research activities in the field of theoretical and experimental reactor physics in the year 1973. A part of this program was included in the NPY Cooperative program in reactor physics. The topics covered by this report are as follows: Calculations of the thermal neutron distribution and reaction rate in a reactor cell and comparison with experiments; buckling measurements; thermalization and slowing down of neutrons; pulsed neutron source techniques; and reactor kinetics

Fossil Energy Program semiannual progress report for April 1992-- September 1992

Energy Technology Data Exchange (ETDEWEB)

Judkins, R.R.

1992-12-01

This report covers progress made during the period April 1, 1992, through September 30, 1992, for research and development projects that contribute to the advancement of various fossil energy technologies. Projects on the Fossil Energy Program are supported by the DOE Office of Fossil Energy, the DOE Morgantown Energy Technology Center, the DOE Pittsburgh Energy Technology Center, the DOE Fossil Energy Clean Coal Technology Program, the DOE Office of Basic Energy Sciences, the DOE Fossil Energy Office of Petroleum Reserves, the DOE Fossil Energy Office of Naval Petroleum and Oil Shale Reserves, and the US Agency for International Development.

Progress Report

Science.gov (United States)

2018-05-16

This report summarizes the annual progress of EPA’s Clean Air Markets Programs such as the Acid Rain Program (ARP) and the Cross-State Air Pollution Rule (CSAPR). EPA systematically collects data on emissions, compliance, and environmental effects, these data are highlighted in our Progress Reports.

Phase II trial of pazopanib in advanced/progressive malignant pheochromocytoma and paraganglioma.

Science.gov (United States)

Jasim, Sina; Suman, Vera J; Jimenez, Camilo; Harris, Pamela; Sideras, Kostandinos; Burton, Jill K; Worden, Francis Paul; Auchus, Richard J; Bible, Keith C

2017-08-01

Pheochromocytomas and paragangliomas (Pheo/PGL) are rare, vascular, sometimes malignant endocrine tumors. Case reports indicate the activity of vascular endothelium growth factor receptor-targeted kinase inhibitors in these cancers. To assess the antitumor activity and tolerability of pazopanib in progressive malignant Pheo/PGL. This multicenter Phase II trial (MC107C) enrolled individuals  ≥18 years old with disease progression ≤ 6 months prior to registration, Eastern Cooperative Oncology Group PS 0-2, and measurable disease (response evaluation criteria in solid tumors 1.0). Pazopanib was administered in 28-day cycles, with the regimen ultimately being as follows: cycle 1: 400 mg daily on days 1-14, cycle 2: 800 mg daily on days 1-14, and then cycle 2 + : 800 mg daily on all days. The study was halted due to poor accrual. Seven patients were enrolled (05/2011-11/2014). One patient withdrew consent prior to treatment, leaving six evaluable patients. Treatment was discontinued, due to the following reasons: disease progression (4); withdrawal (1); and grade 4 (Takotsubo) cardiomyopathy (1). The median number of cycles administered was 4 (range: 2-29, total: 49). Four patients had >1 dose reduction due to the following reasons: fatigue (1), abnormal liver tests (2), hypertension and (Takotsubo) cardiomyopathy (1), and headaches (1). Common severe (Common Terminology Criteria for Adverse Events v3.0 grades 3-5) toxicities were as follows: hypertension (3/6), (Takotsubo) cardiomyopathy (2/6), diarrhea (1/6), fatigue (1/6), headache (1/6), and hematuria (1/6). One confirmed partial response was observed in PGL (17%, duration 2.4 years); median progression-free survival and overall survival were 6.5 and 14.8 months, respectively. Pazopanib has activity in Pheo/PGL requiring more study; optimal alpha- and beta-blockade are imperative pre-therapy in patients with secretory tumors, as risk of hypertension and cardiomyopathy are potentially life

A Carbon Monitoring System Approach to US Coastal Wetland Carbon Fluxes: Progress Towards a Tier II Accounting Method with Uncertainty Quantification

Science.gov (United States)

Windham-Myers, L.; Holmquist, J. R.; Bergamaschi, B. A.; Byrd, K. B.; Callaway, J.; Crooks, S.; Drexler, J. Z.; Feagin, R. A.; Ferner, M. C.; Gonneea, M. E.; Kroeger, K. D.; Megonigal, P.; Morris, J. T.; Schile, L. M.; Simard, M.; Sutton-Grier, A.; Takekawa, J.; Troxler, T.; Weller, D.; Woo, I.

2015-12-01

Despite their high rates of long-term carbon (C) sequestration when compared to upland ecosystems, coastal C accounting is only recently receiving the attention of policy makers and carbon markets. Assessing accuracy and uncertainty in net C flux estimates requires both direct and derived measurements based on both short and long term dynamics in key drivers, particularly soil accretion rates and soil organic content. We are testing the ability of remote sensing products and national scale datasets to estimate biomass and soil stocks and fluxes over a wide range of spatial and temporal scales. For example, the 2013 Wetlands Supplement to the 2006 IPCC GHG national inventory reporting guidelines requests information on development of Tier I-III reporting, which express increasing levels of detail. We report progress toward development of a Carbon Monitoring System for "blue carbon" that may be useful for IPCC reporting guidelines at Tier II levels. Our project uses a current dataset of publically available and contributed field-based measurements to validate models of changing soil C stocks, across a broad range of U.S. tidal wetland types and landuse conversions. Additionally, development of biomass algorithms for both radar and spectral datasets will be tested and used to determine the "price of precision" of different satellite products. We discuss progress in calculating Tier II estimates focusing on variation introduced by the different input datasets. These include the USFWS National Wetlands Inventory, NOAA Coastal Change Analysis Program, and combinations to calculate tidal wetland area. We also assess the use of different attributes and depths from the USDA-SSURGO database to map soil C density. Finally, we examine the relative benefit of radar, spectral and hybrid approaches to biomass mapping in tidal marshes and mangroves. While the US currently plans to report GHG emissions at a Tier I level, we argue that a Tier II analysis is possible due to national

Progress on PEP-II injection R ampersand D

International Nuclear Information System (INIS)

Bloom, E.; Bulos, F.; Fieguth, T.; Godfrey, G.; Loew, G.; Miller, R.

1993-06-01

The R ampersand D program described in this paper focuses on an improvement of the SLAC linac designed to extract and study a 9 GeV electron beam under stringent control of energy, energy spread, emittance, optical parameters, and timing. The extraction system begins with an on-axis pulsed magnet, followed by a magnetic lattice and diagnostic equipment required for the measurement and optimization of the above beam qualities. Design, construction, and installation of this system is the first step in the development of the overall PEP-II e ± injection system. This system is required to fill 1658 bunches of 9 GeV electrons (0.99A stored) and 3.1 GeV positrons (2.14A stored) in two separate rings in a total of about 6 minutes from zero ring current (i.e., full-fill mode, 0 to 100%) or in about 3 minutes from 80% ring current (i.e., topping-off mode, 80 to 100%). This unprecedented rate of filling can be met by a judicious use of the SLC linac, damping rings, and positron source

Progress on PEP-II injection R ampersand D

International Nuclear Information System (INIS)

Bloom, E.; Bulos, F.; Fieguth, T.; Godfrey, G.; Loew, G.; Miller, R.

1993-01-01

The R ampersand D program described in this paper focuses on an improvement of the SLAC linac designed to extract and study a 9 GeV electron beam under stringent control of energy, energy spread, emittance, optical parameters, and timing. The extraction system begins with an on-axis pulsed magnet, followed by a magnetic lattice and diagnostic equipment required for the measurement and optimization of the above beam qualities. Design, construction, and installation of this system is the first step in the development of the overall PEP-II e ± injection system. This system is required to fill 1658 bunches of 9 GeV electrons (0.99A stored) and 3.1 GeV positrons (2.14A stored) in two separate rings in a total of about 6 minutes from zero ring current (i.e., full-fill mode, 0 to 100%) or in about 3 minutes from 80% ring current (i.e., topping-off mode, 80 to 100%). This unprecedented rate of filling can be met by a judicious use of the SLC linac, damping rings, and positron source

Geothermal drilling and completion technology development program. Annual progress report, October 1979-September 1980

Energy Technology Data Exchange (ETDEWEB)

Varnado, S.G. (ed.)

1980-11-01

The progress, status, and results of ongoing research and development (R and D) within the Geothermal Drilling and Completion Technology Development Program are described. The program emphasizes the development of geothermal drilling hardware, drilling fluids, completion technology, and lost circulation control methods. Advanced drilling systems are also under development. The goals of the program are to develop the technology required to reduce well costs by 25% by 1983 and by 50% by 1987.

Review of Physics Research Programs at LAMPF. Progress report, January-December 1983

Energy Technology Data Exchange (ETDEWEB)

Allred, J.C. (ed.)

1984-04-01

Research and development summaries are presented under the main headings: research, proton storage ring construction and research program development, status of LAMPF II, facility and experimental development, and accelerator operations. Complete lists are given for experiments run in 1983, new prospects, and active and complete experiments by channel. (WHK)

Review of Physics Research Programs at LAMPF. Progress report, January-December 1983

International Nuclear Information System (INIS)

Allred, J.C.

1984-04-01

Research and development summaries are presented under the main headings: research, proton storage ring construction and research program development, status of LAMPF II, facility and experimental development, and accelerator operations. Complete lists are given for experiments run in 1983, new prospects, and active and complete experiments by channel

Complex exercise rehabilitation program for women of the II period of age with metabolic syndrome

OpenAIRE

Lee, Eun-Ok; Olga, Kozyreva

2013-01-01

The purpose of this study was to develop a complex exercise program integrating Eastern and Western complex exercise rehabilitation programs in order to examine the effects of it on the human body with the subjects for women of the II period of mature age with metabolic syndrome. The subjects of this study are 60 II period of mature aged women with metabolic syndrome living in G City, and the experimental group conducted Taekwon-aerobic exercise, European rehabilitation gymnastics, gym ball e...

Beneficial Uses Program. Progress report for period ending June 30, 1978. [Irradiated sewage sludge

Energy Technology Data Exchange (ETDEWEB)

1979-01-01

The Beneficial Uses Program is a comprehensive program to develop the necessary technologies for cost-beneficial uses of existing and future surplus radioactive materials. The major portion of the work at Sandia is concentrated in two sub-programs: the Waste Resources Utilization Program and the Separation Technology and Source Development Program. Progress is reported on: (1) the Sandia Irradiator for Dried Sewage Solids; (2) bacteriology; (3) mycology; (4) virology; (5) animal feeds containing irradiated sewage solids; (6) use of irradiated sewage sludge as fertilizer; and (7) development of /sup 137/Cs radiation sources obtained from radioactive wastes. (TFD)

Steam generator tube integrity program: Phase II, Final report

Energy Technology Data Exchange (ETDEWEB)

Kurtz, R.J.; Bickford, R.L.; Clark, R.A.; Morris, C.J.; Simonen, F.A.; Wheeler, K.R.

1988-08-01

The Steam Generator Tube Integrity Program (SGTIP) was a three phase program conducted for the US Nuclear Regulatory Commission (NRC) by Pacific Northwest Laboratory (PNL). The first phase involved burst and collapse testing of typical steam generator tubing with machined defects. The second phase of the SGTIP continued the integrity testing work of Phase I, but tube specimens were degraded by chemical means rather than machining methods. The third phase of the program used a removed-from-service steam generator as a test bed for investigating the reliability and effectiveness of in-service nondestructive eddy-current inspection methods and as a source of service degraded tubes for validating the Phase I and Phase II data on tube integrity. This report describes the results of Phase II of the SGTIP. The object of this effort included burst and collapse testing of chemically defected pressurized water reactor (PWR) steam generator tubing to validate empirical equations of remaining tube integrity developed during Phase I. Three types of defect geometries were investigated: stress corrosion cracking (SCC), uniform thinning and elliptical wastage. In addition, a review of the publicly available leak rate data for steam generator tubes with axial and circumferential SCC and a comparison with an analytical leak rate model is presented. Lastly, nondestructive eddy-current (EC) measurements to determine accuracy of defect depth sizing using conventional and alternate standards is described. To supplement the laboratory EC data and obtain an estimate of EC capability to detect and size SCC, a mini-round robin test utilizing several firms that routinely perform in-service inspections was conducted.

Steam generator tube integrity program: Phase II, Final report

International Nuclear Information System (INIS)

Kurtz, R.J.; Bickford, R.L.; Clark, R.A.; Morris, C.J.; Simonen, F.A.; Wheeler, K.R.

1988-08-01

The Steam Generator Tube Integrity Program (SGTIP) was a three phase program conducted for the US Nuclear Regulatory Commission (NRC) by Pacific Northwest Laboratory (PNL). The first phase involved burst and collapse testing of typical steam generator tubing with machined defects. The second phase of the SGTIP continued the integrity testing work of Phase I, but tube specimens were degraded by chemical means rather than machining methods. The third phase of the program used a removed-from-service steam generator as a test bed for investigating the reliability and effectiveness of in-service nondestructive eddy-current inspection methods and as a source of service degraded tubes for validating the Phase I and Phase II data on tube integrity. This report describes the results of Phase II of the SGTIP. The object of this effort included burst and collapse testing of chemically defected pressurized water reactor (PWR) steam generator tubing to validate empirical equations of remaining tube integrity developed during Phase I. Three types of defect geometries were investigated: stress corrosion cracking (SCC), uniform thinning and elliptical wastage. In addition, a review of the publicly available leak rate data for steam generator tubes with axial and circumferential SCC and a comparison with an analytical leak rate model is presented. Lastly, nondestructive eddy-current (EC) measurements to determine accuracy of defect depth sizing using conventional and alternate standards is described. To supplement the laboratory EC data and obtain an estimate of EC capability to detect and size SCC, a mini-round robin test utilizing several firms that routinely perform in-service inspections was conducted

Status and progress of the RERTR program in the year 2000

International Nuclear Information System (INIS)

Travelli, A.

2000-01-01

This paper describes the progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners during the year 2000 and discusses the main activities planned for the year 2001. The past year was characterized by important accomplishments and events for the RERTR program. Four additional shipments containing 503 spent fuel assemblies from foreign research reactors were accepted by the U.S. Altogether, 3,740 spent fuel assemblies from foreign research reactors have been received by the U.S. under the acceptance policy. Postirradiation examinations of three batches of microplates have continued to reveal excellent irradiation behavior of U-MO dispersion fuels in a variety of compositions and irradiating conditions. h-radiation of two new batches of miniplates of greater sizes is in progress in the ATR to investigate me swelling behavior of these fuels under prototypic conditions. These materials hold the promise of achieving the program goal of developing LEU research reactor fuels with uranium densities in the 8-9 g /cm 3 range. Qualification of the U-MO dispersion fuels is proceeding on schedule. Test fuel elements with 6 gU/cm 3 are being fabricated by BWXT and are scheduled to begin undergoing irradiation in the HFR-Petten in the spring of 2001, with a goal of qualifying this fuel by the end of 2003. U-Mo with 8-9 gU/cm 3 is planned to be qualified by the end of 2005. Joint LEU conversion feasibility studies were completed for HFR-Petten and for SAFARI-1. Significant improvements were made in the design of LEU metal-foil annular targets that would allow efficient production of fission 99 Mo. Irradiations in the RAS-GAS reactor showed that these targets can formed from aluminum tubes, and that the yield and purity of their product from the acidic process were at least as good as those from the HEU Cintichem targets. Progress was made on irradiation testing of LEU UO 2 dispersion fuel and on

SARP-II: Safeguards Accounting and Reports Program, Revised

International Nuclear Information System (INIS)

Kempf, C.R.

1994-01-01

A computer code, SARP (Safeguards Accounting and Reports Program) which will generate and maintain at-facility safeguards accounting records, and generate IAEA safeguards reports based on accounting data input by the user, was completed in 1990 by the Safeguards, Safety, and Nonproliferation Division (formerly the Technical Support Organization) at Brookhaven National Laboratory as a task under the US Program of Technical Support to IAEA safeguards. The code was based on a State System of Accounting for and Control of Nuclear Material (SSAC) for off-load refueled power reactor facilities, with model facility and safeguards accounting regime as described in IAEA Safeguards Publication STR-165. Since 1990, improvements in computing capabilities and comments and suggestions from users engendered revision of the original code. The result is an updated, revised version called SARP-II which is discussed in this report

National Waste Terminal Storage Program. Progress report, October 1, 1976--September 30, 1977

International Nuclear Information System (INIS)

Asher, J.M.

1978-04-01

The National Waste Terminal Storage Program Report comprises five sections: technical projects, facility projects, planning and analysis, regulatory affairs, and public affairs. Progress made in these areas during the period October 1, 1976, to September 30, 1977, is reported

Fossil Energy Program semiannual progress report for October 1991--March 1992

Energy Technology Data Exchange (ETDEWEB)

Judkins, R.R.

1992-11-01

This report covers progress made during the period October 1, 1991, through March 31, 1992, for research and development projects that contribute to the advancement of various fossil energy technologies. Projects on the Fossil Energy Program are supported by the DOE Office of Fossil Energy, the DOE Morgantown Energy Technology Center, the DOE Pittsburgh Energy Technology Center, the DOE Fossil Energy Clean Coal Technology Program, the DOE Office of Basic Energy Sciences, the DOE Fossil Energy Office of Petroleum Reserves, the DOE Fossil Energy Naval Petroleum and Oil Shale Reserves, and the US Agency for International Development. The Fossil Energy Program organization chart is shown in the appendix. Topics discussed are under the following projects: materials research and developments; environmental analysis support; coal conversion development; coal combustion research; and fossil fuels supplies modeling and research.

Recent progress at RTNS-II

International Nuclear Information System (INIS)

Heikkinen, D.W.; Logan, C.M.

1984-01-01

The Rotating Target Neutron Source (RTNS-II) facility produces 14-MeV neutrons for materials damage studies. Initial operation for irradiations, which occurred in 1979, began with a neutron source strength of 10 13 n/s utilizing one of the accelerator-based neutron sources. Details are given on improvements which have resulted in both increased neutron production and neutron source strength and improved control and monitoring. 8 references

Quality-assurance study of the special-purpose finite-element program SPECTROM: II. Plasticity problems

International Nuclear Information System (INIS)

Callahan, G.D.; Fossum, A.F.

1982-11-01

General plasticity theory and solution techniques as are currently employed in RE/SPEC's finite element plasticity code SPECTROM-II are presented. Various yield functions are discussed and their differences are illustrated using example problems. Comparison of the results of SPECTROM-II with analytical solutions, numerical solutions, and the general purpose finite element program MARC-CDC show excellent agreement

Planning for a program design for energy environmental analysis. Progress report

International Nuclear Information System (INIS)

Denton, J.C.

The work reported in this progress report is focused on determining the proper scope of a regional assessment study program suitable for BER/ERDA. Within the tentative scope selected, a tentative set of purposes, goals, and objectives is identified for a preliminary specification of a geographical region. The initial specification of the region includes the states of Pennsylvania, New Jersey, Delaware, Maryland, and Virginia. The tentative scope of considerations for the regional assessment study program encompasses the interacting facets of environment, energy, and economic well-being of the region with the overarching goal of reconciling these facets within the decision framework of the region

Status and progress of the RERTR program in the year 2002

International Nuclear Information System (INIS)

Travelli, A.; Technology Development

2003-01-01

Following the cancellation of the 2001 International RERTR Meeting, which had been planned to occur in Bali, Indonesia, this paper describes the progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners during the years 2001 and 2002, and discusses the main activities planned for the year 2003. The past two years have been characterized by very important achievements of the RERTR program, but these technical achievements have been overshadowed by the terrible events of September 11, 2001. Those events have caused the U.S. Government to reevaluate the importance and urgency of the RERTR program goals. A recommendation made at the highest levels of the government calls for an immediate acceleration of the program activities, with the goal of converting all the world's research reactors to low-enriched fuel at the earliest possible time, and including both Soviet-designed and United States-designed research reactors

Status and progress of the RERTR program in the year 2002

International Nuclear Information System (INIS)

Travelli, Armando

2002-01-01

Following the cancellation of the 2001 International RERTR Meeting, which had been planned to occur in Bali, Indonesia, this paper describes the progress achieved by the Reduced Enrichment for Research and Test Reactors (RERTR) Program in collaboration with its many international partners during the years 2001 and 2002, and discusses the main activities planned for the year 2003. The past two years have been characterized by very important achievements of the RERTR program, but these technical achievements have been overshadowed by the terrible events of September 11, 2001. Those events have caused the U.S. Government to reevaluate the importance and urgency of the RERTR program goals. A recommendation made at the highest levels of the government calls for an immediate acceleration of the program activities, with the goal of converting all the world's research reactors to low-enriched fuel at the earliest possible time, and including both Soviet-designed and United States-designed research reactors. The RERTR program has prepared and submitted to the Department of Energy a plan and a schedule to achieve this goal. The plan makes full use of two very important technical developments that have occurred within the program during the past two years: - Excellent results have been obtained from the irradiation of miniplates containing monolithic LEU U-Mo fuel with uranium density of 15.6 g/cm 3 . If an economically viable manner of fabricating monolithic LEU U-Mo fuel elements is developed, and if the preliminary irradiation tests are confirmed, this fuel holds the promise of enabling LEU operation of all existing and future research reactors in combination with unprecedented performance. - The progress achieved within the Russian RERTR program, both for the traditional tube-type elements and for the new 'universal' LEU U-Mo pin-type elements, promises to enable soon the conversion of most Russian-designed research and test reactors. The plan is structured to achieve LEU

Operational-safety advantages of LMFBR's: the EBR-II experience and testing program

International Nuclear Information System (INIS)

Sackett, J.I.; Lindsay, R.W.; Golden, G.H.

1982-01-01

LMFBR's contain many inherent characteristics that simplify control and improve operating safety and reliability. The EBR-II design is such that good advantage was taken of these characteristics, resulting in a vary favorable operating history and allowing for a program of off-normal testing to further demonstrate the safe response of LMFBR's to upsets. The experience already gained, and that expected from the future testing program, will contribute to further development of design and safety criteria for LMFBR's. Inherently safe characteristics are emphasized and include natural convective flow for decay heat removal, minimal need for emergency power and a large negative reactivity feedback coefficient. These characteristics at EBR-II allow for ready application of computer diagnosis and control to demonstrate their effectiveness in response to simulated plant accidents. This latter testing objective is an important part in improvements in the man-machine interface

Gas-cooled fast reactor program. Progress report, January 1, 1980-June 30, 1981

International Nuclear Information System (INIS)

Kasten, P.R.

1981-09-01

Since the national Gas-Cooled Fast Breeder Reactor Program has been terminated, this document is the last progress report until reinstatement. It is divided into three sections: Core Flow Test Loop, GCFR shielding and physics, and GCFR pressure vessel and closure studies

Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

Index Scriptorium Estoniae

2009-01-01

Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

The RERTR [Reduced Enrichment Research and Test Reactor] program: A progress report

International Nuclear Information System (INIS)

Travelli, A.

1986-11-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1985, the activities, results, and new developments which occurred in 1986 are reviewed. The second miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was expanded and its irradiation continued. Postirradiation examinations of several of these miniplates and of six previously irradiated U 3 Si 2 -Al full-size elements were completed with excellent results. The whole-core ORR demonstration with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 is well under way and due for completion before the end of 1987. DOE removed an important barrier to conversions by announcing that the new LEU fuels will be accepted for reprocessing. New DOE prices for enrichment and reprocessing services were calculated to have minimal effect on HEU reactors, and to reduce by about 8 to 10% the total fuel cycle costs of LEU reactors. New program activities include preliminary feasibility studies of LEU use in DOE reactors, evaluation of the feasibility to use LEU targets for the production of fission-product 99 Mo, and responsibility for coordinating safety evaluations related to LEU conversions of US university reactors, as required by NRC. Achievement of the final program goals is projected for 1990. This progress could not have been achieved without close international cooperation, whose continuation and intensification are essential to the achievement of the ultimate goals of the RERTR Program

Seismic Safety Margins Research Program: Phase II program plan (FY 83-FY 84)

International Nuclear Information System (INIS)

Bohn, M.P.; Bernreuter, D.L.; Cover, L.E.; Johnson, J.J.; Shieh, L.C.; Shukla, S.N.; Wells, J.E.

1982-01-01

The Seismic Safety Margins Research Program (SSMRP) is an NRC-funded, multiyear program conducted by Lawrence Livermore National Laboratory (LLNL). Its goal is to develop a complete, fully coupled analysis procedure (including methods and computer codes) for estimating the risk of an earthquake-caused radioactive release from a commercial nuclear power plant. The analysis procedure is based upon a state-of-the-art evaluation of the current seismic analysis and design process and explicitly includes the uncertainties inherent in such a process. The results will be used to improve seismic licensing requirements for nuclear power plants. As currently planned, the SSMRP will be completed in September, 1984. This document presents the program plan for work to be done during the remainder of the program. In Phase I of the SSMRP, the necessary tools (both computer codes and data bases) for performing a detailed seismic risk analysis were identified and developed. Demonstration calculations were performed on the Zion Nuclear Power Plant. In the remainder of the program (Phase II) work will be concentrated on developing a simplified SSMRP methodology for routine probabilistic risk assessments, quantitative validation of the tools developed and application of the simplified methodology to a Boiling Water Reactor. (The Zion plant is a pressurized water reactor.) In addition, considerable effort will be devoted to making the codes and data bases easily accessible to the public

Antimicrobial Exposure Assessment Task Force II (AEATF II) Volume 5: Governing Document for a Multi-Year Antimicrobial Chemical Exposure Monitoring Program (interim draft document with changes)

Science.gov (United States)

This document describes the overall scope of the AEATF II program, demonstrates the need for additional human exposure monitoring data and explains the proposed methodology for the exposure monitoring studies proposed for conduct by the AEATF II.

FY 2005 Annual Progress Report for the DOE Hydrogen Program

Energy Technology Data Exchange (ETDEWEB)

None

2005-10-01

In cooperation with industry, academia, national laboratories, and other government agencies, the Department of Energy's Hydrogen Program is advancing the state of hydrogen and fuel cell technologies in support of the President's Hydrogen Fuel Initiative. The initiative seeks to develop hydrogen, fuel cell, and infrastructure technologies needed to make it practical and cost-effective for Americans to choose to use fuel cell vehicles by 2020. Significant progress was made in fiscal year 2005 toward that goal.

PDMS-modified poly(styrene-alt-maleic anhydride)s as water-borne coatings based on surfactant-free latexes

NARCIS (Netherlands)

Gunbas, I.D.; Wouters, M.E.L.; Benthem, R.A.T.M. van; Koning, C.E.; Noordover, B.A.J.

2013-01-01

In this work, two series of PDMS-modified poly(styrene-alt-maleic anhydride)s (PSMA) were prepared by the partial imidization of their anhydride groups with mono-functional, amine-terminated polydimethyl siloxanes (PDMS-NH2) with two different molecular weights. Subsequently, surfactant-free

Beneficial uses program. Progress report for period ending March 31, 1977

Energy Technology Data Exchange (ETDEWEB)

None

1977-07-01

Progress is reported in a program aimed at recovering radiation sources from radioactive wastes and using these sources, mainly /sup 137/Cs, for irradiating sewage sludge. Information is included on: development and cost of dried sludge irradiator; heat and radiation inactivation of sludge-contained viruses and bacteria; virucidal agents in sludge; use of thermoradiated sludge as animal feed; and a comparison of the efficiency of various source materials. (LCL)

Progress in EPRI-programs on the inspection of cast austenitic stainless steel

Energy Technology Data Exchange (ETDEWEB)

Dau, G; Behravesh, M; Amirato, P; Stone, R [Electric Power Research Inst., Charlotte, NC (United States). Nondestructive Evaluation Center

1988-12-31

This document presents the progress in EPRI programs on in-service inspection of Cast austenitic Stainless Steel (CSS). The CSS examination strategy is presented, together with results concerning thermal fatigue cracks and mechanical fatigue cracks. A statistical analysis method is provided, in order to estimate the crack detectability and the false call (a non-crack called crack). (TEC).

PROSID - a program to evaluate SIMMER-II results

International Nuclear Information System (INIS)

Flad, M.; Kuefner, K.; Maschek, W.

1990-02-01

The PROSID program supports the evaluation of SIMMER-II results. PROSID enables the user to get a printout of variables, to get a linear combination of variables or quadrats of variables, to sum up variables or quadrats of variables, to compare variables or whole datasets, to interpolate to a new meshgrid and to get weighted mean values. As special options are available the calculation of the volume of connected gas regions, the evaluation of the fuel enrichment, an estimation of reactivity changes and the retransformation of interpolated velocity values. The results can be stored for further evaluations. (orig.) [de

Progress report of a research program in experimental high energy physics, 1 January-31 December 1984

International Nuclear Information System (INIS)

Widgoff, M.

1984-01-01

An experimental program to study the interactions of hadrons, photons, and neutrinos is being carried out using hybrid systems which include bubble chambers as visible targets and counter spectrometers for particle detection, identification, and momentum measurements. Experiments have been run in both positive and negative hadron beams at Fermilab, and with polarized photons at SLAC. Experiments with neutrino beams at Tevatron II at Fermilab are in preparation. We have been analyzing the film and counter data of our one-million-picture exposure for the study of π+-, K + and p interations in hydrogen and magnesium, silver and gold, at a beam momentum of 200 GeV/c, as well as continuing the physics analysis of our earlier FNAL experiments on π + p, K + p, and pp interactions at 147 GeV/c. During the past year analysis has continued on the data of SLAC experiments studying the interactions in hydrogen of 20 GeV polarized photons. Results have been obtained on photoproduction of charm and on the lifetimes of charmed particles, and on vector meson and strange particle production. Inclusive γp interactions are being studied in detail in this high statistics sample. Another experiment, was run at 10.5 GeV, to search for evidence of a predicted threshold enhancement in the charm photoproduction cross section. Preparations are in progress for neutrino interaction studies at Tevatron II. An experiment will run starting early in 1985 in the wide band neutrino beam with hybrid system designed for the tau neutrino search to be run with the beam dump

Frank and Fearless: Supporting Academic Career Progression for Women in an Australian Program

Directory of Open Access Journals (Sweden)

Polly Parker

2018-02-01

Full Text Available The underrepresentation of women in senior positions continues to be a major challenge in higher education and most other industries. In Australia, the career trajectory for academic women stalls at a lower level than that of their male counterparts. Concern about this situation in one Australian university led to the design and delivery of a career progression program to support women’s advancement from senior lecturer to associate professor. This study details the main features of the program, designed to facilitate women’s transition from being leading academics to academic leaders through a focus on leadership and career progression. We report the participants’ perceptions of its value based on survey data. We conclude that leadership development is difficult work and requires a supportive environment where risk-taking is encouraged, where frank and fearless feedback is provided, and where the individual is required to examine assumptions and biases and to assume a leadership identity.

Phase 1 trial of ALT-801, an interleukin-2/T cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies

Science.gov (United States)

Fishman, Mayer N.; Thompson, John A.; Pennock, Gregory K.; Gonzalez, Rene; Diez, Luz M.; Daud, Adil I.; Weber, Jeffery S.; Huang, Bee Y.; Tang, Shamay; Rhode, Peter R.; Wong, Hing C.

2014-01-01

Purpose ALT-801 is a bifunctional fusion protein comprising interleukin-2 (IL-2) linked to a soluble, single-chain T cell receptor domain that recognizes a peptide epitope (aa264-272) of the human p53 antigen displayed on cancer cells in the context of HLA-A*0201 (p53+/HLA-A*0201). We evaluated the safety, pharmacokinetics and pharmacodynamics of ALT-801 in p53+/HLA-A*0201 patients with metastatic malignancies. Experimental Design p53+/HLA-A*0201 patients were treated with ALT-801 on a schedule of 4 daily 15-minute intravenous infusions, then 10 days rest and 4 more daily infusions. Cohorts of patients were treated at 0.015, 0.040, and 0.080 mg/kg/dose. Results Four, sixteen, and six patients were treated at the 0.015, 0.04 and 0.08 mg/kg cohorts, respectively. Two dose limiting toxicities (a grade 4 transient thrombocytopenia and a myocardial infarction) in the 0.08 mg/kg cohort established the maximum tolerated dose (MTD) at 0.04 mg/kg. Patients treated at the MTD experienced toxicities similar to those associated with high-dose IL-2 but of lesser severity. The serum half-life of ALT-801 was 4 hours and ALT-801 serum recovery was as expected based on the dose administered. ALT-801 treatment induced an increase of serum interferon-γ but not tumor necrosis factor-α. Response assessment showed 10 subjects with stable disease at at least 11 weeks, and in one who had melanoma metastasis, there is an ongoing complete absence of identifiable disease after resection of radiographically identified lesions. Conclusion This first-in-man study defines an ALT-801 regimen that can be administered safely and is associated with immunological changes of potential antitumor relevance. PMID:21994418

Short-rotation woody-crops program. Quarterly progress report for period ending August 31, 1981

Energy Technology Data Exchange (ETDEWEB)

Cushman, J.H.; Ranney, J.W.

1982-04-01

Progress of twenty-one projects in the Short Rotation Woody Crops Program is summarized for the period June 1 through August 31, 1981. Individual quarterly reports included from each of the projects discuss accomplishments within specific project objectives and identify recent papers and publications resulting from the research. The major program activities are species screening and genetic selection, stand establishment and cultural treatment, and harvest, collection, transportation, and storage.

Heavy-section steel irradiation program. Progress report, October 1994--March 1995

International Nuclear Information System (INIS)

Corwin, W.R.

1995-10-01

This document is the October 1994-March 1995 Progress Report for the Heavy Section Steel Irradiation Program. The report contains a summary of activities in each of the 14 tasks of the HSSI Program, including: (1) Program management, (2) Fracture toughness shifts in high-copper weldments, (3) Fracture toughness shifts in low upper-shelf welds, (4) Irradiation effects in a commercial low upper-shelf weld, (5) Irradiation effects on weld heat-affected zone and plate materials, (6) Annealing effects in low upper-shelf welds, (7) Microstructural analysis of radiation effects, (8) In-service irradiated and aged material evaluations, (9) Japanese power development reactor vessel steel examination, (10) fracture toughness curve shift method, (11) Special technical assistance, (12) Technical assistance for JCCCNRS, (13) Correlation monitor materials, and (14) Test reactor irradiation coordination. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database

The 1988 CEA progress report on laser research programs

International Nuclear Information System (INIS)

Anon.

1988-01-01

The 1988 CEA progress report, concerning laser investigations, is presented. The aim of the research programs on laser/matter interactions is to contribute to the military application works on this field, as well as to the development of the inertial confinement fusion physics. The activities related to the installation and starting of Phebus laser system are described. The development of soft x-ray instrumentation are included. In the field of numerical simulations, the improvement of FCI 1 and 2 codes are extended for increasing the field of the physical phenomena taken into account and getting their use more flexible to the experiment analysis [fr

#whitegenocide, the Alt-right and Conspiracy Theory: How Secrecy and Suspicion Contributed to the Mainstreaming of Hate

Directory of Open Access Journals (Sweden)

Andrew F. Wilson,

2018-02-01

Full Text Available This article considers the relationship between “hashtag activism” as it is currently being used by the alt-right and the tendency to draw on conspiracy theory that Richard Hofstadter identified as being prevalent among what he termed “pseudo-conservatives” half a century earlier. Both the alt-right and Hofstadter’s “pseudo-conservatives” can be characterised by a pronounced populist nationalism that understands its aims as protecting a particular way of life whilst drawing on an aggrieved sense of injustice at being conspired against by an unseen enemy. That this “enemy” is typically foreign in actuality or in spirit confirms the cultural dimension on which their politics is played out. It is argued here that this paranoid populist nationalism has been figuratively drawn upon in the rhetoric of Donald Trump and that this apparent openness to the “pseudo-conservative” discourse on nationalism has provided a bridging effect via which far right elements are seeking to normalize extremist viewpoints

Commercial waste treatment program annual progress report for FY 1983

Energy Technology Data Exchange (ETDEWEB)

McElroy, J.L.; Burkholder, H.C. (comps.)

1984-02-01

This annual report describes progress during FY 1983 relating to technologies under development by the Commercial Waste Treatment Program, including: development of glass waste form and vitrification equipment for high-level wastes (HLW); waste form development and process selection for transuranic (TRU) wastes; pilot-scale operation of a radioactive liquid-fed ceramic melter (LFCM) system for verifying the reliability of the reference HLW treatment proces technology; evaluation of treatment requirements for spent fuel as a waste form; second-generation waste form development for HLW; and vitrification process control and product quality assurance technologies.

LASL Controlled Thermonuclear Research Program. Progress report, January--December 1976

International Nuclear Information System (INIS)

Thomas, K.S.

1978-03-01

This annual progress report is divided into the following sections: (1) Scyllac feedback sector experiments, (2) staged theta-pinch program, (3) toroidal reverse-field pinch, (4) Scylla IV-P linear theta-pinch experiments, (5) gun injection experiment, (6) Scylla I-C, laser-plasma interaction studies, (7) field reversal theta pinch, (8) Implosion Heating Experiment, (9) experimental plasma physics, (10) plasma diagnostics, (11) high-beta tokamak, (12) theory, (13) computers, (14) engineering, (15) magnetic energy transfer and storage, (16) magnetic confinement systems studies, and (17) intense neutron source facility

Progress of Nuclear Hydrogen Program in Korea

International Nuclear Information System (INIS)

Lee, Won Jae

2009-01-01

To cope with dwindling fossil fuels and climate change, it is clear that a clean alternative energy that can replace fossil fuels is required. Hydrogen is considered a promising future energy solution because it is clean, abundant and storable and has a high energy density. As other advanced countries, the Korean government had established a long-term vision for transition to the hydrogen economy in 2005. One of the major challenges in establishing a hydrogen economy is how to produce massive quantities of hydrogen in a clean, safe and economical way. Among various hydrogen production methods, the massive, safe and economic production of hydrogen by water splitting using a very high temperature gas-cooled reactor (VHTR) can provide a success path to the hydrogen economy. Particularly in Korea, where usable land is limited, the nuclear production of hydrogen is deemed a practical solution due to its high energy density. To meet the expected demand for hydrogen, the Korea Atomic Energy Institute (KAERI) launched a nuclear hydrogen program in 2004 together with Korea Institute of Energy Research (KIER) and Korea Institute of Science and Technology (KIST). Then, the nuclear hydrogen key technologies development program was launched in 2006, which aims at the development and validation of key and challenging technologies required for the realization of the nuclear hydrogen production demonstration system. In 2008, Korean Atomic Energy Commission officially approved a long-term development plan of the nuclear hydrogen system technologies as in the figure below and now the nuclear hydrogen program became the national agenda. This presentation introduces the current status of nuclear hydrogen projects in Korea and the progress of the nuclear hydrogen key technologies development. Perspectives of nuclear process heat applications are also addressed

TRUPACT-II container maintenance program plan

International Nuclear Information System (INIS)

1990-11-01

This document details the maintenance/repair and replacement of components, as well as the documentation required and the procedures to be followed to maintain the integrity of the TRUPACT-II container, in accordance with requirements of the TRUPACT-II Container Operations and Maintenance Manual, OM-134, the TRUPACT-II Container Safety Analysis Report (SARP), and the TRUPACT-II Container Certificate of Compliance (Number 9218). The routine shipping and receiving inspections required by the Department of Transportation (DOT), Department of Energy (DOE), Nuclear Regulatory Commission (NRC) and other regulations are not addressed in this document. This document applies to all DOE shipping and receiving sites that use the TRUPACT-II containers

National Waste Terminal Storage Program. Progress report, April 1, 1975--September 30, 1976

International Nuclear Information System (INIS)

1976-01-01

This report is divided into two parts: the Management Report and the Technical Report. Section 1 of the Management Report provides a general National Waste Terminal Storage program overview, which includes a summary of the long-range plan. Part II contains the status reports of the technical projects, facility projects, and systems projects

Current progress in implementing the payments-equal-to-taxes (PETT) program in Nevada

International Nuclear Information System (INIS)

Lundgaard, E.L.; Ellis, C.B.

1993-01-01

The Nuclear Waste Policy Act of 1982, as amended (NWPA), requires the Secretary of Energy to make Payments-equal-to-Taxes (PETT) to local units of government that are affected by the potential repository at Yucca Mountain, Nevada. The PETT program is designed to provide affected jurisdictions with the revenue they would have received if the potential repository site was being characterized and possibly developed by a private entity rather than the Federal government. A paper presented at last year's conference described how the PETT Program would be implemented in the State of Nevada. This paper describes the current progress in implementing the program as it relates to the PETT associated with property taxes

Fuel performance improvement program. Quarterly/annual progress report, October 1977--September 1978

International Nuclear Information System (INIS)

Crouthamel, C.E.

1978-10-01

This quarterly/annual report reviews and summarizes the activities performed in support of the Fuel Performance Improvement Program (FPIP) during Fiscal Year 1978 with emphasis on those activities that transpired during the quarter ending September 30, 1978. Significant progress has been made in achieving the primary objectives of the program, i.e., to demonstrate commercially viable fuel concepts with improved fuel - cladding interaction (FCI) behavior. This includes out-of-reactor experiments to support the fuel concepts being evaluated, initiation of instrumented test rod experiments in the Halden Boiling Water Reactor (HBWR), and fabrication of the first series of demonstration rods for irradiation in the Big Rock Point Reactor

Naised käsu korras firmade juhatusse! Jah või ei? / Kairi Alt, Aveli Kippari, Karl Koort... [jt.

Index Scriptorium Estoniae

2011-01-01

Küsimusele vastavad Columbus IT Partner Eesti AS personalijuht Kairi Alt, Stele ja Riveli omanik Aveli Kippari, AS Panaviatic'i turundusjuht Karl Koort, OÜ Tarkvara Tehnoloogia Arenduskeskuse tegevjuht Indrek Vainu, AS PricewaterhouseCoopers auditiosakonna direktor Eva Jansen, Kalev Chocolate Factory tootmisjuht Hardo Reinike

Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

Energy Technology Data Exchange (ETDEWEB)

1993-09-30

This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

Phase II study of radiopeptide {sup 177}Lu-octreotate and capecitabine therapy of progressive disseminated neuroendocrine tumours

Energy Technology Data Exchange (ETDEWEB)

Claringbold, Phillip G. [Fremantle Hospital, Department of Oncology, Fremantle, WA (Australia); Brayshaw, Paul A.; Turner, J.H. [University of Western Australia, Department of Nuclear Medicine, Fremantle Hospital, Fremantle, WA (Australia); Price, Richard A. [Fremantle Hospital, Department of Radiology, Fremantle, WA (Australia)

2011-02-15

In this phase II study we investigated the safety and efficacy of combination capecitabine and {sup 177}Lu-octreotate for the treatment of disseminated, progressive, unresectable neuroendocrine tumours (NETs). Enrolled in the study were 33 patients with biopsy-proven NETs, positive {sup 111}In-octreotide scintigraphy and progressive disease measurable by CT/MRI who were to receive four cycles of 7.8 GBq {sup 177}Lu-octreotate 8-weekly, with 14 days of 1,650 mg/m{sup 2} capecitabine per day. Of the 33 patients, 25 completed four cycles. Minimal transient myelosuppression at 3-4 weeks caused grade 3 thrombocytopenia in one patient but no neutropenia. Nephrotoxicity was absent. Critical organ radiation dosimetry provided median estimates of the dose per cycle to the kidneys of 2.4 Gy and to the liver of 4.8 Gy, and showed cumulative doses all below toxic thresholds. Objective response rates (ORR) were 24% partial response (PR), 70% stable disease (SD) and 6% progressive disease. Median progression-free survival and median overall survival had not been reached at a median follow-up of 16 months (range 5-33 months). Survival at 1 and 2 years was 91% (95% CI 75-98%) and 88% (95% CI 71-96%), respectively. The addition of capecitabine radiosensitizing chemotherapy does not increase the minimal toxicity of {sup 177}Lu-octreotate radiopeptide therapy and led to an ORR of 24% PR and 70% minor response or SD in patients with progressive metastatic NETs. Tumour control and stabilization of disease was obtained in 94% of these patients. (orig.)

Full-scale mark II CRT program data report no. 7

International Nuclear Information System (INIS)

Kukita, Yutaka; Namatame, Ken; Yamamoto, Nobuo; Takeshita, Isao; Shiba, Masayoshi

1980-03-01

The Full-Scale Mark II CRT (Containment Response Test) Program was initiated in 1977 to provide a data base for evaluation of the LOCA hydrodynamic loads in the BWR Mark II pressure suppression system. The test facility is 1/18 in volume and has a wetwell which is a full-scale replica of one 20 0 -sector of that of a reference Mark II. This report documents test data obtained from TEST 3102, which is a large (200 mm) water break test performed on June 29, 1979. The test was performed for a supernominal break area (approx. 160% of the scaled break area for a postulated double-ended break in the recirculation line) to obtain vent steam mass fluxes ranging up to the maximum design value of the actual plants. Before the initiation of the test more than 90% of the drywell air was replaced by steam and transferred into wetwell airspace to reduce the air content in the vent flow during the test. Because of this pre-test treatment (so-called prepurging) the test data obtained for high- and intermediate-steam-flux condensation oscillations are believed to be to a high degree on conservative side. (author)

Rhone-Poulenc claims progress for environment program

International Nuclear Information System (INIS)

Back, R.

1993-01-01

Rhone-Poulenc (RP; Paris) made further progress last year in its pollution-reducing efforts, under the group's worldwide three-year Environment Plan (1992--1994). The company's water index improved by 15% from 1991 and by 22% from 1990 -- slightly ahead of target. The air index improved 9% from 1991 and 15% from 1990. open-quotes Progress regarding atmospheric emissions is significant, but we wish to go further in order to reach our medium-term objectives,close quotes says RP vice-chairman Jean-Marc Bruel. About 47% of the company's capital spending in 1992 was devoted to these emissions. The solid waste index remained static, with an improvement of 1% compared with an 18% advance in 1991. The startup of incineration units in 1993 will help correct this situation. Bruel reiterates the group's established goal of a 50% reduction in all effluent and solid waste by 1995, and 65% by 2000, using 1990 as the base year for its environment index. He says the indices have been adopted by the French chemical industry association -- Union des Industries Chimiques -- and the U.K.'s Chemical Industries Association. RP's environment-related expenditures in 1992 amounted to F1.8 billion ($330 million), of which F1.2 billion was for operating expenses and the remainder for new investments. Expenditures in France were F594 million and F479 million, respectively; the US, F381 million and F122 million; and Brazil F64 million and F14 million. Spending is forecast to be at a similar level in 1993. Environmental research, with spending of F5.8 billion in 1992, is integrated into all the group's research programs

Los Alamos National Laboratory Science Education Programs. Quarterly progress report, April 1--June 30, 1995

Energy Technology Data Exchange (ETDEWEB)

Gill, D.

1995-09-01

This report is quarterly progress report on the Los Alamos National Laboratory Science Education Programs. Included in the report are dicussions on teacher and faculty enhancement, curriculum improvement, student support, educational technology, and institutional improvement.

Subseabed disposal program annual report, January-December 1978. Volume II. Principal investigator progress reports

International Nuclear Information System (INIS)

1979-10-01

The topics covered in this report include: geologic siting considerations for the disposal of radioactive wastes into submarine geologic formations; geologic assessment of the MPG-1 regions Central North Pacific; site mapping; geotechnical aspects of subsurface seabed disposal; heat transfer, thermal and fluid physics in the deep ocean sediments; mechanical response predictive capability; sediment-seawater interaction at 300 0 C, 500 bars; stability of actinides in chloride media; cannister corrosion studies; nuclide sorption and migration; development of apparatus and measurement of thermal conductivity of seabed illite and smectite at temperatures to 500 0 C at simulated depths to 15,000 ft (9000 psi); in-situ heat transfer experiments; preliminary seabed disposal transport modeling studies; radionuclide migration studies; radionuclide distributions in deep ocean cores; benthic biological studies; deep sea microbial studies; activity rates of abyssal communities; Deep-towed RUM III (Sandia Seabed working platform): a third-generation remote underwater manipulator; long coring facility program; transportation; legal, political, and institutional implications of the Seabed Program for radioactive waste disposal

Factors related to progression and graduation rates for RN-to-bachelor of science in nursing programs: searching for realistic benchmarks.

Science.gov (United States)

Robertson, Sue; Canary, Cheryl Westlake; Orr, Marsha; Herberg, Paula; Rutledge, Dana N

2010-03-01

Measurement and analysis of progression and graduation rates is a well-established activity in schools of nursing. Such rates are indices of program effectiveness and student success. The Commission on Collegiate Nursing Education (2008), in its recently revised Standards for Accreditation of Baccalaureate and Graduate Degree Nursing Programs, specifically dictated that graduation rates (including discussion of entry points, timeframes) be calculated for each degree program. This context affects what is considered timely progression to graduation. If progression and graduation rates are critical outcomes, then schools must fully understand their measurement as well as interpretation of results. Because no national benchmarks for nursing student progression/graduation rates exist, schools try to set expectations that are realistic yet academically sound. RN-to-bachelor of science in nursing (BSN) students are a unique cohort of baccalaureate learners who need to be understood within their own learning context. The purposes of this study were to explore issues and processes of measuring progression and graduation rates in an RN-to-BSN population and to identify factors that facilitate/hinder their successful progression to work toward establishing benchmarks for success. Using data collected from 14 California schools of nursing with RN-to-BSN programs, RN-to-BSN students were identified as generally older, married, and going to school part-time while working and juggling family responsibilities. The study found much program variation in definition of terms and measures used to report progression and graduation rates. A literature review supported the use of terms such as attrition, retention, persistence, graduation, completion, and success rates, in an overlapping and sometimes synonymous fashion. Conceptual clarity and standardization of measurements are needed to allow comparisons and setting of realistic benchmarks. One of the most important factors identified

Resonance energy transfer from quinolinone modified polystyrene-block-poly(styrene-alt-maleic anhydride) copolymer to terbium(III) metal ions

Energy Technology Data Exchange (ETDEWEB)

Výprachtický, Drahomír, E-mail: vyprachticky@imc.cas.cz [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6 (Czech Republic); Mikeš, František [New York University Polytechnic School of Engineering, Polymer Research Institute, 6 MetroTech Center, Brooklyn, NY 11201 (United States); Lokaj, Jan; Pokorná, Veronika; Cimrová, Věra [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6 (Czech Republic)

2015-04-15

Polystyrene-block-poly(styrene-alt-maleic anhydride) was synthesized by nitroxide mediated radical polymerization and modified with 7-amino-4-methylquinolin-2(1H)-one (I) and methanol. The formed block polymer ligand contained a quinolinone fluorophore (Ω) and carboxyl (III) or sodium carboxylate (IV) binding sites. The ligand-to-metal resonance energy transfer (RET) and ligand binding properties of [III–Tb{sup 3+}] and [IV–Tb{sup 3+}] complexes were investigated by steady-state and time-resolved luminescence spectroscopy in tetrahydrofuran/methanol and/or tetrahydrofuran/deuterated methanol mixtures and compared with those of a low-molecular-weight model ligand, i.e. the sodium salt of N-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)succinamic acid (II). The long-lived emission intensities of Tb{sup 3+} at 490, 545, 585, and 620 nm corresponding to the {sup 5}D{sub 4}→{sup 7}F{sub 6}, {sup 5}D{sub 4}→{sup 7}F{sub 5}, {sup 5}D{sub 4}→{sup 7}F{sub 4}, and {sup 5}D{sub 4}→{sup 7}F{sub 3} transitions, respectively, were strongly increased by the addition of ligands in the order [II-Tb{sup 3+}]⪡[III-Tb{sup 3+}]<[IV-Tb{sup 3+}]. The efficiency of energy transfer (E) was evaluated from the emission intensity of the donor (Ω) in the presence or absence of the acceptor (Tb{sup 3+}) depending on the acceptor concentration and ligand neutralization. It was concluded that the macromolecular ligand structural properties (polymer coil and supramolecular structures, e.g. micelles) were responsible for the increase in RET. The time-resolved luminescence measurements revealed that the binding affinity of the ligands II, III, and IV increased in the order II

Progression og underviserkompetencer

Directory of Open Access Journals (Sweden)

Lene Tortzen Bager

2014-03-01

Full Text Available På baggrund af en kvalitativ interviewundersøgelse af undervisere ved Aarhus Universitet lavet i 2012, tematiserer artiklen, hvordan undervisere udvikler deres faglige og pædagogiske kompetencer i forhold til at kunne skabe progression inden for innovation og entreprenørskab forstået enten som didaktik, arbejdsformer i faglige forløb eller som fag på universitetet. I arbejdet med progression er det en udfordring at integrere de nye faglige dimensioner i det kernefaglige felt. Den seneste model for progression inden for innovation og entreprenør-skab siger, at det er den lærendes generelle erfaringsniveau, der er den afgørende progressionsskabende faktor (Progressionsmodellen, Fonden for Entreprenørskab, 2013b. Samtidig skelner international forskning inden for studiekompetenceområdet mellem niveauer, hvor indlejret viden er det mest avancerede kompetenceniveau (Barrie, 2002.Ifølge progressionsmodellen og den nævnte kompetenceforskning er erfaring og dybt integreret læring altså centrale dimensioner i progression. Men hvad er underviserens rolle heri? Underviserens professionelle udviklingsarbejde forekommer at være underbelyst i forhold til, at underviseren er den legitime garant for integrationen af nye faglige dimensioner og for den studerendes kompetenceniveau. Interviewundersøgelsen forholder sig til spørgsmålet om progression gennem de deltagende underviseres beskrivelse af betydningslag i entreprenørskabsbegrebet koblet til de praksisformer i undervisningen, der knytter sig hertil samt et indblik i undervisernes refleksioner over deres kompetenceudviklingsprocesser. Artiklens bidrag til progression er at se underviserens motivation og kompetenceudvikling som forudsætninger herfor.     Based on a qualitative study of five teachers in the Faculty of Arts at Aarhus University that took place during 2012, the article thematizes how teachers develop their professional and educational qualifications in innovation and

Proceedings of the 1995 U.S. DOE hydrogen program review. Volume II

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

The 1995 US DOE Hydrogen Program Review was held April 18-21, 1995 in Coral Gables, FL. Volume II of the Proceedings contains 8 papers presented under the subject of hydrogen storage and 17 papers presented on hydrogen production. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

F-35 Lightning II Joint Strike Fighter (JSF) Program: Background, Status, and Issues

National Research Council Canada - National Science Library

Bolkcom, Christopher; Murch, Anthony

2008-01-01

The Defense Department's F-35 Lightning II Joint Strike Fighter (JSF) is one of three aircraft modernization programs in tactical aviation, the others being the Air Force F-22A fighter and the Navy F/A-18E/F fighter/attack plane...

F-35 Lightning II Joint Strike Fighter "JSF" Program: Background, Status, and Issues

National Research Council Canada - National Science Library

Murch, Anthony; Bolkcom, Christopher

2007-01-01

The Defense Department's F-35 Lightning II Joint Strike Fighter (JSF) is one of three aircraft modernization programs in tactical aviation, the others being the Air Force F-22A fighter and the Navy F/A-18E/F fighter/attack plane...

F-35 Lightning II Joint Strike Fighter (JSF) Program: Background, Status, and Issues

National Research Council Canada - National Science Library

Bolkcom, Christopher

2009-01-01

The Defense Department's F-35 Lightning II Joint Strike Fighter (JSF) is one of three aircraft modernization programs in tactical aviation, the others being the Air Force F-22A fighter and the Navy F/A-18E/F fighter/attack plane...

Spent Fuel and Waste Management Technology Development Program. Annual progress report

Energy Technology Data Exchange (ETDEWEB)

Bryant, J.W.

1994-01-01

This report provides information on the progress of activities during fiscal year 1993 in the Spent Fuel and Waste Management Technology Development Program (SF&WMTDP) at the Idaho Chemical Processing Plant (ICPP). As a new program, efforts are just getting underway toward addressing major issues related to the fuel and waste stored at the ICPP. The SF&WMTDP has the following principal objectives: Investigate direct dispositioning of spent fuel, striving for one acceptable waste form; determine the best treatment process(es) for liquid and calcine wastes to minimize the volume of high level radioactive waste (HLW) and low level waste (LLW); demonstrate the integrated operability and maintainability of selected treatment and immobilization processes; and assure that implementation of the selected waste treatment process is environmentally acceptable, ensures public and worker safety, and is economically feasible.

Simple synthesis of P(Cbz-alt-TBT) and PCDTBT by combining direct arylation with suzuki polycondensation of heteroaryl chlorides.

Science.gov (United States)

Lombeck, Florian; Matsidik, Rukiya; Komber, Hartmut; Sommer, Michael

2015-01-01

Direct arylation (DA) of 2-chlorothiophene and 2-chloro-3-hexylthiophene with 4,7-dibromo-2,1,3-benzothiadiazole is used to synthesize 4,7-bis(5-chloro-2-thienyl)-2,1,3-benzothiadiazole (TBTCl2) and 4,7-bis(5-chloro-4-hexyl-2-thienyl)-2,1,3-benzothiadiazole (DH-TBTCl2) in one step. Suitable conditions of the Suzuki polycondensations (SPC) of TBTCl2 and DH-TBTCl2 with the carbazole comonomer CbzPBE2 are established, furnishing PCDTBT and P(Cbz-alt-TBT) with high molecular weight and yield. Compared with control samples made from the corresponding dibromides, high-temperature NMR and UV-vis spectroscopy indicate similar properties for PCDTBT but an increased content of Cbz-Cbz homocouplings for P(Cbz-alt-TBT). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AFR spent fuel storage program. Technical progress report, January 1981-March 1981

International Nuclear Information System (INIS)

1981-01-01

Work on this project is focused on developing design and licensing information for the model facility. Deliverables were submitted to DOE for facility modification, security design, and licensing documentation. Work is essentially complete on the high-density rack design with deliverable planned for April 30, 1981. A continuing program for completion of design and licensing information development was initiated by AGNS in February 1981. Progress to date is satisfactory

TRUPACT-II Container Maintenance Program Plan

International Nuclear Information System (INIS)

1991-05-01

This document details the maintenance, repair, and replacement of components, as well as the documentation required and the procedures to be followed to maintain the integrity of the TRUPACT-II container in accordance with OM-134, TRUPACT-II Container Operations and Maintenance Manual; and the TRUPACT-II Container Certificate of Compliance (Number 9218). The routine shipping and receiving inspections required by the Department of Transportation (DOT), Department of Energy (DOE), Nuclear Regulatory Commission (NRC) and other regulations are not addressed in this document. This document applies to all DOE shipping and receiving sites that use the TRUPACT-II containers

General-purpose heat source project and space nuclear safety and fuels program. Progress report

International Nuclear Information System (INIS)

Maraman, W.J.

1980-02-01

Studies related to the use of 238 PuO 2 in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of LASL are presented. The three programs involved are: general-purpose heat source development; space nuclear safety; and fuels program. Three impact tests were conducted to evaluate the effects of a high temperature reentry pulse and the use of CBCF on impact performance. Additionally, two 238 PuO 2 pellets were encapsulated in Ir-0.3% W for impact testing. Results of the clad development test and vent testing are noted. Results of the environmental tests are summarized. Progress on the Stirling isotope power systems test and the status of the improved MHW tests are indicated. The examination of the impact failure of the iridium shell of MHFT-65 at a fuel pass-through continued. A test plan was written for vibration testing of the assembled light-weight radioisotopic heater unit. Progress on fuel processing is reported

The Economic and Clinical Impact of Sustained Use of a Progressive Mobility Program in a Neuro-ICU.

Science.gov (United States)

Hester, Jeannette M; Guin, Peggy R; Danek, Gale D; Thomas, Jaime R; Titsworth, William L; Reed, Richard K; Vasilopoulos, Terrie; Fahy, Brenda G

2017-06-01

To investigate a progressive mobility program in a neurocritical care population with the hypothesis that the benefits and outcomes of the program (e.g., decreased length of stay) would have a significant positive economic impact. Retrospective analysis of economic and clinical outcome data before, immediately following, and 2 years after implementation of the Progressive Upright Mobility Protocol Plus program (UF Health Shands Hospital, Gainesville, FL) involving a series of planned movements in a sequential manner with an additional six levels of rehabilitation in the neuro-ICU at UF Health Shands Hospital. Thirty-bed neuro-ICU in an academic medical center. Adult neurologic and neurosurgical patients: 1,118 patients in the pre period, 731 patients in the post period, and 796 patients in the sustained period. Implementation of Progressive Upright Mobility Protocol Plus. ICU length of stay decreased from 6.5 to 5.8 days in the immediate post period and 5.9 days in the sustained period (F(2,2641) = 3.1; p = 0.045). Hospital length of stay was reduced from 11.3 ± 14.1 days to 8.6 ± 8.8 post days and 8.8 ± 9.3 days sustained (F(2,2641) = 13.0; p mobility program in the neurocritical care population has clinical and financial benefits associated with its implementation and should be considered.

NRC review of passive reactor design certification testing programs: Overview, progress, and regulatory perspective

Energy Technology Data Exchange (ETDEWEB)

Levin, A.E.

1995-09-01

New reactor designs, employing passive safety systems, are currently under development by reactor vendors for certification under the U.S. Nuclear Regulatory Commission`s (NRC`s) design certification rule. The vendors have established testing programs to support the certification of the passive designs, to meet regulatory requirements for demonstration of passive safety system performance. The NRC has, therefore, developed a process for the review of the vendors` testing programs and for incorporation of the results of those reviews into the safety evaluations for the passive plants. This paper discusses progress in the test program reviews, and also addresses unique regulatory aspects of those reviews.

Does a Rehabilitation Program of Aerobic and Progressive Resisted Exercises Influence HIV-Induced Distal Neuropathic Pain?

Science.gov (United States)

Maharaj, Sonill S; Yakasai, Abdulsalam M

2018-05-01

Distal symmetrical polyneuropathy is a common neurological sequela after HIV, which leads to neuropathic pain and functional limitations. Rehabilitation programs with exercises are used to augment pharmacological therapy to relieve pain but appropriate and effective exercises are unknown. This study explored the safety and effect of moderate-intensity aerobic exercises and progressive resisted exercises for HIV-induced distal symmetrical polyneuropathy neuropathic pain. A randomized pretest, posttest of 12 wks of aerobic exercise or progressive resisted exercise compared with a control. Outcome measures were assessed using the subjective periphery neuropathy, brief peripheral neuropathy screening, and numeric pain rating scale. Pain was assessed at baseline, 6 and 12 wks. Data between groups were compared using Kruskal-Wallis, Mann-Whitney U test, and within-groups Friedman and Wilcoxon signed rank tests. There were 136 participants (mean [SD] age = 36.79 [8.23] yrs) and the exercise groups completed the protocols without any adverse effects. Pain scores within and between aerobic exercise and progressive resisted exercise groups showed significant improvement (P 0.05). This study supports a rehabilitation program of moderate-intensity aerobic exercise and progressive resisted exercise being safe and effective for reducing neuropathic pain and is beneficial with analgesics for HIV-induced distal symmetrical polyneuropathy.

Hearing loss in Usher syndrome type II is nonprogressive.

Science.gov (United States)

Reisser, Christoph F V; Kimberling, William J; Otterstedde, Christian R

2002-12-01

Usher syndrome is an autosomal recessive disorder characterized by sensorineural hearing loss and progressive visual loss secondary to retinitis pigmentosa. In the literature, a possible progression of the moderate to severe hearing loss in Usher syndrome type II (Usher II) is controversial. We studied the development of the hearing loss of 125 patients with a clinical diagnosis of Usher syndrome type II intraindividually and interindividually by repeatedly performing complete audiological and neuro-otologic examinations. Our data show a very characteristic slope of the hearing curve in all Usher II patients and no clinically relevant progression of the hearing loss over up to 17 years. The subjective impression of a deterioration of the communicative abilities of Usher II patients must therefore be attributed to the progressive visual loss. The patients should be reassured that changes in their hearing abilities are unlikely and should be provided with optimally fitted modern hearing aids.

Damage analysis and fundamental studies. Quarterly progress report, July--September 1978

Energy Technology Data Exchange (ETDEWEB)

Zwilsky, Klaus M.

1979-05-01

This report is the third in a series of Quarterly Technical Progress Reports on Damage Analysis and Fundamental Studies (DAFS) which is one element of the Fusion Reactor Materials Program, conducted in support of the Magnetic Fusion Energy Program. This report is organized along topical lines in parallel to Section II, Damage Analysis and Fundamental Studies (DOE/ET-0032/2), of the Fusion Reactor Materials Program Plan so that activities and accomplishments may be followed readily relative to that Program Plan. Thus, the work of a given laboratory may appear throughout the report. Chapters 1 and 2 report topics which are generic to all of the DAFS Program: DAFS Task Group Activities and Irradiation Test Facilities, respectively. Chapters 3, 4, and 5 report the work that is specific to each of the subtasks around which the program is structured: A) Environmental Characterization, B) Damage Production, and C) Damage Microstructure Evolution and Mechanical Behavior.

Progress in fusion technology in the U.S. magnetic fusion program

International Nuclear Information System (INIS)

Dowling, R.J.; Beard, D.S.; Haas, G.M.; Stone, P.M.; George, T.V.

1987-01-01

In this paper the authors discuss the major technological achievements that have taken place during the past few years in the U.S. magnetic fusion program which have contributed to the global efforts. The goal has been to establish the scientific and technological base required for fusion energy. To reach this goal the fusion RandD program is focused on four key technical issues: determine the optimum configuration of magnetic confinement systems; determine the properties of burning plasmas; develop materials for fusion systems; and establish the nuclear technology of fusion systems. The objective of the fusion technology efforts has been to develop advanced technologies and provide the necessary support for research of these four issues. This support is provided in a variety of areas such as: high vacuum technology, large magnetic field generation by superconducting and copper coils, high voltage and high current power supplies, electromagnetic wave and particle beam heating systems, plasma fueling, tritium breeding and handling, remote maintenance, energy recovery. The U.S. Fusion Technology Program provides major support or has the primary responsibility in each of the four key technical issues of fusion, as described in the Magnetic Fusion Program Plan of February 1985. This paper has summarized the Technology Program in terms of its activities and progress since the Proceedings of the SOFT Conference in 1984

Inertial Fusion Program. Progress report, July 1-December 31, 1979

International Nuclear Information System (INIS)

Skoberne, F.

1981-10-01

Progress in the development of high-energy short-pulse CO 2 laser systems for fusion research is reported. Improvements in the Los Alamos National Laboratory eight-beam Helios system are described. These improvements increased the reliability of the laser and permitted the firing of 290 shots, most of which delivered energies of approximately 8 kJ to the target. Modifications to Gemini are outlined, including the installation of a new target-insertion mechanism. The redirection of the Antares program is discussed in detail, which will achieve a total energy of approximatey 40 kJ with two beams. This redirection will bring Antares on-line almost two years earlier than was possible with the full six-beam system, although at a lower energy. Experiments with isentropically imploded Sirius-B targets are discussed, and x-ray radiation-loss data from gold microballoons are presented, which show that these results are essentially identical with those obtained at glass-laser wavelengths. Significant progress in characterizing laser fusion targets is reported. New processes for fabricating glass miroballoon x-ray diagnostic targets, the application of high-quality metallic coatings, and the deposition of thick plastic coatings are described. Results in the development of x-ray diagnostics are reported, and research in the Los Alamos heavy-ion fusion program is summarized. Results of investigations of phase-conjugation research of gaseous saturable absorbers and of the use of alkali-halide crystals in a new class of saturable absorbers are summarized. New containment-vessel concepts for Inertial Confinement Fusion reactors are discussed, and results of a scoping study of four fusion-fission hybrid concepts are presented

[Vision test program for ophthalmologists on Apple II, IIe and IIc computers].

Science.gov (United States)

Huber, C

1985-03-01

A microcomputer program for the Apple II family of computers on a monochrome and a color screen is described. The program draws most of the tests used by ophthalmologists, and is offered as an alternative to a projector system. One advantage of the electronic generation of drawings is that true random orientation of Pflueger's E is possible. Tests are included for visual acuity (Pflueger's E, Landolt rings, numbers and children's drawings). Colored tests include a duochrome test, simple color vision tests, a fixation help with a musical background, a cobalt blue test and a Worth figure. In the astigmatic dial a mobile pointer helps to determine the axis. New tests can be programmed by the user and exchanged on disks among collageues.

Baseline gas turbine development program. Seventeenth quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Schmidt, F W; Wagner, C E

1977-01-31

Progress is reported for a program whose goals are to demonstrate an experimental upgraded gas turbine powered automobile which meets the 1978 Federal Emissions Standards, has significantly improved fuel economy, and is competitive in performance, reliability, and potential manufacturing cost with the conventional piston engine powered, compact-size American automobile. Initial running of the upgraded engine took place on July 13, 1976. The engine has proved to be mechanically sound, but has also been seriously deficient in power. Principal program effort has therefore been in the area of diagnostic testing and corrective development. To date, three upgraded engines have been assembled and run in the test cell. Engine 2 was installed in an upgraded vehicle and became operational on January 25, 1977. Special diagnostic instrumentation was installed on Engine 3 to evaluate the compressor, turbine, and hot engine leakage. It was determined that the power deficiency was principally due to problems in the compressor and first stage turbine areas and during this quarter several corrective changes have been initiated. Parts for a fourth engine being built for NASA Lewis have been shipped to NASA for installation of special instrumentation.

Modeling transducer impulse responses for predicting calibrated pressure pulses with the ultrasound simulation program Field II

DEFF Research Database (Denmark)

Bæk, David; Jensen, Jørgen Arendt; Willatzen, Morten

2010-01-01

FIELD II is a simulation software capable of predicting the field pressure in front of transducers having any complicated geometry. A calibrated prediction with this program is, however, dependent on an exact voltage-to-surface acceleration impulse response of the transducer. Such impulse response...... is not calculated by FIELD II. This work investigates the usability of combining a one-dimensional multilayer transducer modeling principle with the FIELD II software. Multilayer here refers to a transducer composed of several material layers. Measurements of pressure and current from Pz27 piezoceramic disks...... transducer model and the FIELD II software in combination give good agreement with measurements....

Hydrology and Radionuclide Migration Program: 1989 progress report

International Nuclear Information System (INIS)

Marsh, K.V.

1992-08-01

This report presents results from the Lawrence Livermore National Laboratory's participation in the Hydrology and Radionuclide Migration Program (HRMP) at the Nevada Test Site (NTS) during fiscal year 1989. The report compares and summarizes studies of radionuclide and stable element transport atf radionuclide and stable the Cheshire and Cambric sites; progress toward the understanding of colloidal particle transport in porous and fractured media; further calibration of Marinelli beaker containers for gamma-ray spectroscopy; and an appendix listing all announced tests fired near the water table through October 1989. Four such tests were fired in FY89. Laboratory and model investigations of colloid transport in porous and fractured media have supported ongoing field investigations at the NTS. Aqueous chemistry has been shown to control colloid attachment and release from clean mineral surfaces. For colloidal deposits on fracture walls, the current experimental program will determine how this material responds to hydrodynamic forcing and if the porous colloidal deposit causes the more rapid transport of colloids than non-sorbing tracers. Fifteen radionuclides are either frequently found or likely to be found in HRMP and other environmental samples. For 3 of these 15 we have calibrated 4 gamma-ray detectors for use with samples contained in Marinelli beakers. Our calibrations for these three nuclides indicate that the technique is accurate and applicable to the types of environmental samples that we analyze

OR TEP-II: a FORTRAN Thermal-Ellipsoid Plot Program for crystal structure illustrations

International Nuclear Information System (INIS)

Johnson, C.K.

1976-03-01

A computer program is described for drawing crystal structure illustrations using a mechanical plotter. Ball-and-stick type illustrations of a quality suitable for publication are produced with either spheres or thermal-motion probability ellipsoids on the atomic sites. The program can produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns. Interatomic distances, bond angles, and principal axes of thermal motion are also calculated to aid the structural study. The most recent version of the program, OR TEP-II, has a hidden-line-elimination feature to omit those portions of atoms or bonds behind other atoms or bonds

OR TEP-II: a FORTRAN Thermal-Ellipsoid Plot Program for crystal structure illustrations

Energy Technology Data Exchange (ETDEWEB)

Johnson, C.K.

1976-03-01

A computer program is described for drawing crystal structure illustrations using a mechanical plotter. Ball-and-stick type illustrations of a quality suitable for publication are produced with either spheres or thermal-motion probability ellipsoids on the atomic sites. The program can produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns. Interatomic distances, bond angles, and principal axes of thermal motion are also calculated to aid the structural study. The most recent version of the program, OR TEP-II, has a hidden-line-elimination feature to omit those portions of atoms or bonds behind other atoms or bonds.

Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, January 1--June 30, 1988

Energy Technology Data Exchange (ETDEWEB)

Baum, J W; Boccio, J L; Diamond, D; Fitzpatrick, R; Ginsberg, T; Greene, G A; Guppy, J G; Hall, R E; Higgins, J C; Weiss, A J [comp.

1988-12-01

This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through December 31, 1987.

Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, October 1--December 31, 1988

Energy Technology Data Exchange (ETDEWEB)

Weiss, A J; Azarm, A; Baum, J W; Boccio, J L; Carew, J; Diamond, D J; Fitzpatrick, R; Ginsberg, T; Greene, G A; Guppy, J G; Haber, S B

1989-07-01

This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through September 30, 1988.

Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, January 1--June 30, 1988

International Nuclear Information System (INIS)

Baum, J.W.; Boccio, J.L.; Diamond, D.

1988-12-01

This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through December 31, 1987

Diorganosilacetylene-alt-diorganosilvinylene polymers and a process densifying porous silicon-carbide bodies

Science.gov (United States)

Barton, Thomas J.; Ijadi-Maghsoodi, Sina; Pang, Yi

1994-05-17

The present invention provides linear organosilicon polymers including acetylene and vinylene moieties, and a process for their preparation. These diorganosilacetylene-alt-diorganosilvinylene linear polymers can be represented by the formula: --[--(R.sup.1)(R.sup.2)Si--C.tbd.C--(R.sup.3)(R.sup.4)Si--CH=CH--].sub.n-- , wherein n.gtoreq.2; and each R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, aryl, and aralkyl radicals. The polymers are soluble in organic solvents, air stable, and can be pulled into fibers or cast into films. They can be thermally converted into silicon carbide ceramic materials.

LCLS-II high power RF system overview and progress

Energy Technology Data Exchange (ETDEWEB)

Yeremian, Anahid Dian

2015-10-07

A second X-ray free electron laser facility, LCLS-II, will be constructed at SLAC. LCLS-II is based on a 1.3 GHz, 4 GeV, continuous-wave (CW) superconducting linear accelerator, to be installed in the first kilometer of the SLAC tunnel. Multiple types of high power RF (HPRF) sources will be used to power different systems on LCLS-II. The main 1.3 GHz linac will be powered by 280 1.3 GHz, 3.8 kW solid state amplifier (SSA) sources. The normal conducting buncher in the injector will use four more SSAs identical to the linac SSAs but run at 2 kW. Two 185.7 MHz, 60 kW sources will power the photocathode dual-feed RF gun. A third harmonic linac section, included for linearizing the bunch energy spread before the first bunch compressor, will require sixteen 3.9 GHz sources at about 1 kW CW. A description and an update on all the HPRF sources of LCLS-II and their implementation is the subject of this paper.

Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) in serum: results from an IFCC multicenter study.

Science.gov (United States)

Ceriotti, Ferruccio; Henny, Joseph; Queraltó, Josep; Ziyu, Shen; Özarda, Yeşim; Chen, Baorong; Boyd, James C; Panteghini, Mauro

2010-11-01

Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) measurements are important for the assessment of liver damage. The aim of this study was to define the reference intervals (RIs) for these enzymes in adults, paying attention to standardization of the methods used and careful selection of the reference population. AST, ALT and GGT were measured with commercial analytical systems standardized to the IFCC-recommended reference measurement systems. Three centers (two in Italy and one in China) measured their own freshly collected samples; one of these centers also measured frozen samples from the Nordic Countries RI Project and from a Turkish center. RIs were generated using non-parametric techniques from the results of 765 individuals (411 females and 354 males, 18-85 years old) selected on the basis of the results of other laboratory tests and a specific questionnaire. AST results from the four regions (Milan, Beijing, Bursa and Nordic Countries) were statistically different, but these differences were too small to be clinically relevant. Likewise, differences between the upper reference limits for genders was only 1.7 U/L (0.03 μkat/L), allowing a single RI of 11-34 U/L (0.18-0.57 μkat/L) to be defined. Interregional differences were not statistically significant for ALT, but partitioning was required due to significant gender differences. RIs for ALT were 8-41 U/L (0.13-0.68 μkat/L) for females and 9-59 U/L (0.15-0.99 μkat/L) for males, respectively. The upper reference limits for GGT from the Nordic Country population were higher than those from the other three regions and results from this group were excluded from final calculations. The GGT RIs were 6-40 U/L (0.11-0.66 μkat/L) for females and 12-68 U/L (0.20- 1.13 μkat/L) for males, respectively. For AST and ALT, the implementation of common RIs appears to be possible, because no differences between regions were observed. However, a common RI for GGT that is

Application Programming in AWIPS II

Science.gov (United States)

Smit, Matt; McGrath, Kevin; Burks, Jason; Carcione, Brian

2012-01-01

Since its inception almost 8 years ago, NASA's Short-term Prediction Research and Transition (SPoRT) Center has integrated NASA data into the National Weather Service's decision support system (DSS) the Advanced Weather Interactive Processing System (AWIPS). SPoRT has, in some instances, had to shape and transform data sets into various formats and manipulate configurations to visualize them in AWIPS. With the advent of the next generation of DSS, AWIPS II, developers will be able to develop their own plugins to handle any type of data. Raytheon is developing AWIPS II to be a more extensible package written mainly in Java, and built around a Service Oriented Architecture. A plugin architecture will allow users to install their own code modules, and (if all the rules have been properly followed) they will work hand-in-hand with AWIPS II as if it were originally built in. Users can bring in new datasets with existing plugins, tweak plugins to handle a nuance or desired new functionality, or create an entirely new visualization layout for a new dataset. SPoRT is developing plugins to ensure its existing NASA data will be ready for AWIPS II when it is delivered, and to prepare for the future of new instruments on upcoming satellites.

Fossil Energy Program annual progress report for April 1994 through March 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-06-01

This report covers progress made during the period April 1, 1994, through March 31, 1995, for research and development projects that contribute to the advancement of various fossil energy technologies. Projects on the Fossil Energy Program are supported by the DOE Office of Fossil Energy, and DOE Morgantown Energy Technology Center, the DOE Pittsburgh Energy Technology Center, the DOE Fossil Energy Clean Coal Technology Program, the DOE Bartlesville Project Office, and the DOE Fossil Energy Office of Strategic Petroleum Reserve. The following research areas are covered in this report: Materials research and development; Environmental analysis support; Bioprocessing research; Coal combustion research; and Fossil fuels supplies modeling and research. Selected papers have been processed separately for inclusion in the Energy Science an Technology database.

Technical progress report for UTSI/CFFF MHD program completion and related activity

International Nuclear Information System (INIS)

Chapman, James N.; Muehlhauser, Joel W.

1998-01-01

Routine preventive maintenance of the DOE Coal Fired Flow Facility (CFFF) is being performed. Modernization programs, funded under subcontract from Foster Wheeler Development Corporation by the DOE HIPPS Program, have been completed on the coal processing system, the data acquisition and control system and the control room. Late in the quarter, all work was stopped on maintenance of the CFFF at DOE instruction. Environmental restoration actions continued with monitoring of groundwater wells and holding pond effluent. Progress is reported on the approved groundwater remediation plan. Actions are underway to dispose of spent seed/ash mixtures and excess coal remaining from the MHD POC program. The status of five (5) High Temperature Superconductor (HTS) projects is reported. A summary is included of the results attained with sol-gel experiments with buffer layers and YBCO. The status of the cost/performance study of electron beam and PLD deposition is pre-sented. A summary of work performed in diagnostics for real time control of HTS processes is presented

TECHNICAL PROGRESS REPORT FOR UTSI/CFFF MHD PROGRAM COMPLETION AND RELATED ACTIVITIES

Energy Technology Data Exchange (ETDEWEB)

DR. JAMES N. CHAPMAN; DR. JOEL W. MUEHLHAUSER

1998-10-23

Routine preventive maintenance of the DOE Coal Fired Flow Facility (CFFF) is being performed. Modernization programs, funded under subcontract from Foster Wheeler Development Corporation by the DOE HIPPS Program, have been completed on the coal processing system, the data acquisition and control system and the control room. Late in the quarter, all work was stopped on maintenance of the CFFF at DOE instruction. Environmental restoration actions continued with monitoring of groundwater wells and holding pond effluent. Progress is reported on the approved groundwater remediation plan. Actions are underway to dispose of spent seed/ash mixtures and excess coal remaining from the MHD POC program. The status of five (5) High Temperature Superconductor (HTS) projects is reported. A summary is included of the results attained with sol-gel experiments with buffer layers and YBCO. The status of the cost/performance study of electron beam and PLD deposition is pre-sented. A summary of work performed in diagnostics for real time control of HTS processes is presented.

Impact of a community-based lymphedema management program on episodes of Adenolymphangitis (ADLA and lymphedema progression--Odisha State, India.

Directory of Open Access Journals (Sweden)

Katherine E Mues

2014-09-01

Full Text Available Lymphedema management programs have been shown to decrease episodes of adenolymphangitis (ADLA, but the impact on lymphedema progression and of program compliance have not been thoroughly explored. Our objectives were to determine the rate of ADLA episodes and lymphedema progression over time for patients enrolled in a community-based lymphedema management program. We explored the association between program compliance and ADLA episodes as well as lymphedema progression.A lymphedema management program was implemented in Odisha State, India from 2007-2010 by the non-governmental organization, Church's Auxiliary for Social Action, in consultation with the Centers for Disease Control and Prevention. A cohort of patients was followed over 24 months. The crude 30-day rate of ADLA episodes decreased from 0.35 episodes per person-month at baseline to 0.23 at 24 months. Over the study period, the percentage of patients who progressed to more severe lymphedema decreased (P-value  = 0.0004, while those whose lymphedema regressed increased over time (P-value<0.0001. Overall compliance to lymphedema management, lagged one time point, appeared to have little to no association with the frequency of ADLA episodes among those without entry lesions (RR = 0.87 (0.69, 1.10 and was associated with an increased rate (RR = 1.44 (1.11, 1.86 among those with entry lesions. Lagging compliance two time points, it was associated with a decrease in the rate of ADLA episodes among those with entry lesions (RR = 0.77 (95% CI: 0.59, 0.99 and was somewhat associated among those without entry lesions (RR = 0.83 (95% CI: 0.64, 1.06. Compliance to soap was associated with a decreased rate of ADLA episodes among those without inter-digital entry lesions.These results indicate that a community-based lymphedema management program is beneficial for lymphedema patients for both ADLA episodes and lymphedema. It is one of the first studies to demonstrate an association between program

Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression.

Science.gov (United States)

Reguart, Noemi; Rosell, Rafael; Cardenal, Felipe; Cardona, Andres F; Isla, Dolores; Palmero, Ramon; Moran, Teresa; Rolfo, Christian; Pallarès, M Cinta; Insa, Amelia; Carcereny, Enric; Majem, Margarita; De Castro, Javier; Queralt, Cristina; Molina, Miguel A; Taron, Miquel

2014-05-01

Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a novel histone deacetylase inhibitor with demonstrated antiproliferative effects due to drug-induced accumulation of acetylated proteins, including the heat shock protein 90. We prospectively studied the activity of vorinostat plus erlotinib in EGFR-mutated NSCLC patients with progression to tyrosine kinase inhibitors. We conducted this prospective, non-randomized, multicenter, phase I/II trial to evaluate the maximum tolerated dose, toxicity profile and efficacy of erlotinib and vorinostat. Patients with advanced NSCLC harboring EGFR mutations and progressive disease after a minimum of 12 weeks on erlotinib were included. The maximum tolerated dose of vorinostat plus erlotinib was used as recommended dose for the phase II (RDP2) to assess the efficacy of the combination. The primary end point was progression-free-survival rate at 12 weeks (PFSR12w). Pre-treatment plasma samples were required to assess T790M resistant mutation. A total of 33 patients were enrolled in the phase I-II trial. The maximum tolerated dose was erlotinib 150 mg p.o., QD, and 400mg p.o., QD, on days 1-7 and 15-21 in a 28-day cycle. Among the 25 patients treated at the RDP2, the most common toxicities included anemia, fatigue and diarrhea. No responses were observed. PFSR12w was 28% (IC 95%: 18.0-37.2); median progression-free survival (PFS) was 8 weeks (IC 95%: 7.43-8.45) and overall survival (OS) 10.3 months (95% CI: 2.4-18.1). Full dose of continuous erlotinib with vorinostat 400mg p.o., QD on alternative weeks can be safely administered. Still, the combination has no meaningful activity in EGFR-mutated NSCLC patients after TKI progression. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

METHUSELAH II - A Fortran program and nuclear data library for the physics assessment of liquid-moderated reactors

International Nuclear Information System (INIS)

Brinkworth, M.J.; Griffiths, J.A.

1966-03-01

METHUSELAH II is a Fortran program with a nuclear data library, used to calculate cell reactivity and burn-up in liquid-moderated reactors. It has been developed from METHUSELAH I by revising the nuclear data library, and by introducing into the program improvements relating to nuclear data, improvements in efficiency and accuracy, and additional facilities which include a neutron balance edit, specialised outputs, fuel cycling, and fuel costing. These developments are described and information is given on the coding and usage of versions of METHUSELAH II for the IBM 7030 (STRETCH), IBM 7090, and KDF9 computers. (author)

Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus.

Science.gov (United States)

Monteiro, Diana Amaral; Selistre-de-Araújo, Heloisa Sobreiro; Tavares, Driele; Fernandes, Marisa Narciso; Kalinin, Ana Lúcia; Rantin, Francisco Tadeu

2017-09-28

Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis. The aim of this study was to evaluate the systemic effects of a single dose of alternagin-C (0.5 mg·kg -1 , via intra-arterial) on oxidative stress biomarkers, histological alterations, vascular endothelial growth factor (VEGF) production, and the degree of vascularization in the liver of the freshwater fish traíra, Hoplias malabaricus , seven days after the initiation of therapy. ALT-C treatment increased VEGF levels and hepatic angiogenesis. ALT-C also enhanced hepatic antioxidant enzymes activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, decreasing the basal oxidative damage to lipids and proteins in the fish liver. These results indicate that ALT-C improved hepatic tissue and may play a crucial role in tissue regeneration mechanisms.

Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, July 1--September 30, 1988

Energy Technology Data Exchange (ETDEWEB)

Weiss, A J [comp.

1989-02-01

This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through June 30, 1988. 71 figs., 24 tabs.

Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, July 1--September 30, 1988

International Nuclear Information System (INIS)

Weiss, A.J.

1989-02-01

This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through June 30, 1988. 71 figs., 24 tabs

Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources. Progress report

Energy Technology Data Exchange (ETDEWEB)

Finnerty, W. R.

1976-07-01

Progress is reported in four research areas of solar bioconversion. The first program deals with the genetic selection of superior trees, physiological basis of vigor, tissue culture, haploid cell lines, and somatic hybridization. The second deals with the physiology of paraquat-induced oleoresin biogenesis. Separate abstracts were prepared for the other two program areas: biochemical basis of paraquat-induced oleoresin production in pines and biochemistry of methanogenesis. (JSR)

Waste resources utilization program. Progress report, period ending 30 June 1975

International Nuclear Information System (INIS)

1975-08-01

Initial progress on the Waste Resources Utilization Program, a joint effort sponsored by ERDA and EPA under the terms of Interagency Agreement E(29-2)-3536/EPA-IAG-D5-0675 is reported. This program has as its objective the use of 134 Cs/ 137 Cs (a potential nuclear reactor ''waste resource'') as a gamma radiation source, coupled with modest heating, to treat sewage sludge (another ''waste resource'') to rid it of pathogenic organisms so that it may be safely used as a fertilizer or a feed supplement for ruminant animals. The potential exists for using at least 50 percent of the by-product cesium from future reactor fuel-rod reprocessing in this one application alone. Activities dealing with research on many aspects of the problem such as pathogen reduction, physical and chemical effects, cost benefit analysis, safety and security, and systems engineering are reported. (U.S.)

Inertial Fusion Program. Progress report, January-December 1980

International Nuclear Information System (INIS)

1982-05-01

This report summarizes research and development effort in support of the Inertial Confinement Fusion program, including absorption measurements with an integrating sphere, generation of high CO 2 -laser harmonics in the backscattered light from laser plasmas, and the effects of hydrogen target contamination on the hot-electron temperature and transport. The development of new diagnostics is outlined and measurements taken with a proximity-focused x-ray streak camera are presented. High gain in phase conjugation using germanium was demonstrated, data were obtained on retropulse isolation by plasmas generated from metal shutters, damage thresholds for copper mirrors at high fluences were characterized, and phase conjugation in the ultraviolet was demonstrated. Significant progress in the characterization of targets, new techniques in target coating, and important advances in the development of low-density, small-cell-size plastic foam that permit highly accurate machining to any desired shape are presented. The results of various fusion reactor system studies are summarized

Inertial Fusion Program. Progress report, January-December 1980

Energy Technology Data Exchange (ETDEWEB)

1982-05-01

This report summarizes research and development effort in support of the Inertial Confinement Fusion program, including absorption measurements with an integrating sphere, generation of high CO/sub 2/-laser harmonics in the backscattered light from laser plasmas, and the effects of hydrogen target contamination on the hot-electron temperature and transport. The development of new diagnostics is outlined and measurements taken with a proximity-focused x-ray streak camera are presented. High gain in phase conjugation using germanium was demonstrated, data were obtained on retropulse isolation by plasmas generated from metal shutters, damage thresholds for copper mirrors at high fluences were characterized, and phase conjugation in the ultraviolet was demonstrated. Significant progress in the characterization of targets, new techniques in target coating, and important advances in the development of low-density, small-cell-size plastic foam that permit highly accurate machining to any desired shape are presented. The results of various fusion reactor system studies are summarized.

PIP-II Injector Test: Challenges and Status

Energy Technology Data Exchange (ETDEWEB)

Derwent, P. F. [Fermilab; Carneiro, J. P. [Fermilab; Edelen, J. [Fermilab; Lebedev, V. [Fermilab; Prost, L. [Fermilab; Saini, A. [Fermilab; Shemyakin, A. [Fermilab; Steimel, J. [Fermilab

2016-10-04

The Proton Improvement Plan II (PIP-II) at Fermilab is a program of upgrades to the injection complex. At its core is the design and construction of a CW-compatible, pulsed H- superconducting RF linac. To validate the concept of the front-end of such machine, a test accelerator known as PIP-II Injector Test is under construction. It includes a 10mA DC, 30 keV H- ion source, a 2 m-long Low Energy Beam Transport (LEBT), a 2.1 MeV CW RFQ, followed by a Medium Energy Beam Transport (MEBT) that feeds the first of 2 cryomodules increasing the beam energy to about 25 MeV, and a High Energy Beam Transport section (HEBT) that takes the beam to a dump. The ion source, LEBT, RFQ, and initial version of the MEBT have been built, installed, and commissioned. This report presents the overall status of the Injector Test warm front end, including results of the beam commissioning through the installed components, and progress with SRF cryomodules and other systems.

SCINFI II A program to calculate the standardization curve in liquid scintillation counting

Energy Technology Data Exchange (ETDEWEB)

Grau Carles, A.; Grau Malonda, A.

1985-07-01

A code, SCINFI II, written in BASIC, has been developed to compute the efficiency-quench standardization curve for any beta radionuclide. The free parameter method has been applied. The program requires the standardization curve for 3{sup H} and the polynomial or tabulated relating counting efficiency as figure of merit for both 3{sup H} and the problem radionuclide. The program is applied to the computation, of the counting efficiency for different values of quench when the problem is 14{sup C}. The results of four different computation methods are compared. (Author) 17 refs.

SCINFI II A program to calculate the standardization curve in liquid scintillation counting

International Nuclear Information System (INIS)

Grau Carles, A.; Grau Malonda, A.

1985-01-01

A code, SCINFI II, written in BASIC, has been developed to compute the efficiency-quench standardization curve for any beta radionuclide. The free parameter method has been applied. The program requires the standardization curve for 3 H and the polynomial or tabulated relating counting efficiency as figure of merit for both 3 H and the problem radionuclide. The program is applied to the computation, of the counting efficiency for different values of quench when the problem is 14 C . The results of four different computation methods are compared. (Author) 17 refs

76 FR 45221 - Notice of Funding Availability: Inviting Applications for the Food for Progress Program

Science.gov (United States)

2011-07-28

...://www.fas.usda.gov/excredits/FoodAid/FFP/FrameworkGuidance.asp . VI. Proposal Review Criteria A. Review... beneficiaries realistic for the proposed activities? (f) Are the beneficiaries and criteria for selection... Applications for the Food for Progress Program Announcement Type: New. Catalog of Federal Domestic Assistance...

Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias

Directory of Open Access Journals (Sweden)

Justino Alavez Domínguez

2006-12-01

Full Text Available Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral para el estudio de la dinámica del virus de la hepatitis C (VHC, con el modelo de la dinámica viral con alanina aminotransferasa (ALT. En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.aThe standard model of three populations (healthy and unhealthy hepatocytes, and viral load for the study of the dynamics of hepatitis C virus (HCV, is compared with viral dynamic model with alanine aminotransferase (ALT. In terms of the threshold parameter that it’s the same for both models, the existence and local asymptotic stability of the endemically infected equilibrium steady state, and the global stability of the healthy individual equilibrium steady state are established. Furthermore, an experimental study is presented showing that it’s possible to carry out the monitoring of hepatic damage biopsies free by numerical parameter estimation, considering only viral load and ALT levels measurements and a reasonable assessment of pretreatment hepatic damage.

Chemical speciation of Pb(II, Cd(II, Hg(II, Co(II, Ni(II, Cu(II and Zn(II binary complexes of l-methionine in 1,2-propanediol-water mixtures

Directory of Open Access Journals (Sweden)

M. Padma Latha

2007-04-01

Full Text Available Chemical speciation of Pb(II, Cd(II, Hg(II, Co(II, Ni(II, Cu(II and Zn(II complexes of L-methionine in 0.0-60 % v/v 1,2-propanediol-water mixtures maintaining an ionic strength of 0.16 M at 303 K has been studied pH metrically. The active forms of ligand are LH2+, LH and L-. The predominant species detected are ML, MLH, ML2, ML2H, ML2H2 and MLOH. Models containing different numbers of species were refined by using the computer program MINIQUAD 75. The best-fit chemical models were arrived at based on statistical parameters. The trend in variation of complex stability constants with change in the dielectric constant of the medium is explained on the basis of electrostatic and non-electrostatic forces.

Comparing the characteristics of highly cited titles and highly alted titles

Energy Technology Data Exchange (ETDEWEB)

Didegah, F.; Bowman, T.D.; Bowman, S.; Hartley, J.

2016-07-01

This study examines differences in the types of titles for articles that show high altmetric activity (highly alted articles) versus highly cited articles. This work expands on previous research on document titles in combination with a grounded theory approach to develop a codebook in which articles were manually coded based on 11 characteristics. The results show that there are differences and similarities in titles across many of the examined characteristics; highly cited titles and highly mentioned titles on Wikipedia have some similar characteristics such as they have the the highest percentage of substantive words; in addition, there are no or very few titles referencing outside or with humor/lightness on both platforms. Twitter and Facebook also showed some similarities having the highest percentage of humorous/light titles and lowest percentage of substantive words in their titles. (Author)

Advanced Turbine Systems (ATS) program conceptual design and product development. Quarterly progress report, December 1, 1995--February 29, 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-06-01

This report describes the overall program status of the General Electric Advanced Gas Turbine Development program, and reports progress on three main task areas. The program is focused on two specific products: (1) a 70-MW class industrial gas turbine based on the GE90 core technology, utilizing a new air cooling methodology; and (2) a 200-MW class utility gas turbine based on an advanced GE heavy-duty machine, utilizing advanced cooling and enhancement in component efficiency. The emphasis for the industrial system is placed on cycle design and low emission combustion. For the utility system, the focus is on developing a technology base for advanced turbine cooling while achieving low emission combustion. The three tasks included in this progress report are on: conversion to a coal-fueled advanced turbine system, integrated program plan, and design and test of critical components. 13 figs., 1 tab.

The human RNA polymerase II-associated factor 1 (hPaf1: a new regulator of cell-cycle progression.

Directory of Open Access Journals (Sweden)

Nicolas Moniaux

2009-09-01

Full Text Available The human PAF (hPAF complex is part of the RNA polymerase II transcription apparatus and regulates multiple steps in gene expression. Further, the yeast homolog of hPaf1 has a role in regulating the expression of a subset of genes involved in the cell-cycle. We therefore investigated the role of hPaf1 during progression of the cell-cycle.Herein, we report that the expression of hPaf1, a subunit of the hPAF complex, increases with cell-cycle progression and is regulated in a cell-cycle dependant manner. hPaf1 specifically regulates a subclass of genes directly implicated in cell-cycle progression during G1/S, S/G2, and G2/M. In prophase, hPaf1 aligns in filament-like structures, whereas in metaphase it is present within the pole forming a crown-like structure, surrounding the centrosomes. Moreover, hPaf1 is degraded during the metaphase to anaphase transition. In the nucleus, hPaf1 regulates the expression of cyclins A1, A2, D1, E1, B1, and Cdk1. In addition, expression of hPaf1 delays DNA replication but favors the G2/M transition, in part through microtubule assembly and mitotic spindle formation.Our results identify hPaf1 and the hPAF complex as key regulators of cell-cycle progression. Mutation or loss of stoichiometry of at least one of the members may potentially lead to cancer development.

Environmentally Sensitive Areas Surveys Program threatened and endangered species survey: Progress report. Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

King, A.L.; Awl, D.J.; Gabrielsen, C.A.

1994-09-01

The Endangered Species Act (originally passed in 1973) is a Federal statute that protects both animal and plant species. The Endangered Species Act identifies species which are, without careful management, in danger of becoming extinct and species that are considered threatened. Along with the designation of threatened or endangered, the Endangered Species Act provides for the identification of appropriate habitat for these species. Since 1993, the United States Department of Energy`s (DOE) Environmental Restoration (ER) Program has supported a program to survey the Oak Ridge Reservation (ORR) for threatened and endangered species. The Environmentally Sensitive Areas Surveys Program initiated vascular plant surveys during fiscal year 1993 and vertebrate animal surveys during fiscal year 1994 to determine the baseline condition of threatened and endangered species on the ORR at the present time. Data collected during these surveys are currently aiding Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Remedial Investigations on the ORR. They also provide data for ER and Waste Management decision documents, ensure that decisions have technical and legal defensibility, provide a baseline for ensuring compliance with principal legal requirements and will increase public confidence in DOE`s adherence to all related environmental resources rules, laws, regulations, and instructions. This report discusses the progress to date of the threatened and endangered species surveys of the ORR.

RTNS-II [Rotating Target Neutron Source II] operational summary

International Nuclear Information System (INIS)

Heikkinen, D.W.

1988-09-01

The Rotating Target Neutron Source II facility (RTNS-II) operated for over nine years. Its purpose was to provide high intensities of 14 MeV neutrons for materials studies in the fusion energy program. For the period from 1982-1987, the facility was supported by both the US (Department of Energy) and Japan (Ministry of Education, Culture, and Science). RTNS-II contains two accelerator-based neutron sources which use the T(d,n) 4 He reaction. In this paper, we will summarize the operational history of RTNS-II. Typical operating parameters are given. In addition, a brief description of the experimental program is presented. The current status and future options for the facility are discussed. 7 refs., 5 tabs

Geothermal progress monitor. Progress report No. 1

Energy Technology Data Exchange (ETDEWEB)

1979-12-01

Progress is reported on the following: electrical uses, direct-heat uses, drilling activities, leases, geothermal loan guarantee program, general activities, and legal, institutional, and regulatory activites. (MHR)

Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus tricolor L. as a Complementary Therapy For Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT

Directory of Open Access Journals (Sweden)

Dimas Adhi Pradana

2016-12-01

Full Text Available This study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L. with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT. A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1.

National Registry of Cardiac Rehabilitation Programs in Mexico II (RENAPREC II).

Science.gov (United States)

Ilarraza-Lomelí, Hermes; García-Saldivia, Marianna; Rojano-Castillo, Jessica; Justiniano, Samuel; Cerón, Norma; Aranda-Ayala, Zulema-L; Rodríguez, Azucena; Hernández, Alejandro; Cassaigne, María-Elena; Cantero, Raúl; Gasca, Pablo; Hinojosa, Tania; Alonso, Jesús; Romo, Ricardo; Lara, Jorge; Pimentel, Elizabeth; Zavala, Juana; Rius-Suárez, María-Dolores; Cherebetiu, Gabriel; Cortés, Othniel; Almaraz, Alejandro; Mendoza, Pedro; Silva, Jesús; Tirado, Enrique; Martínez, Leonel

The aim of this paper is to compare the state of Cardiac Rehabilitation Programs (CRP) in 2009 with 2015. Focus is directed on health care, training of health-providers, research, and the barriers to their implementation. All authors of RENAPREC-2009, and other cardiac rehabilitation leaders in Mexico were requested to participate. These centres were distributed into two groups: RENAPREC-2009 centres that participated in 2015, and the new CRP units. In 2009 there were 14 centres, two of which disappeared and another two did not respond. CRP-units increased by 71% (n=24), and their geographic distribution shows a centripetal pattern. The coverage of CRP-units was 0.02 centres per 100,000 inhabitants. Only 4.4% of eligible patients were referred to CRP, with a rate of 10.4 patients/100,000 inhabitants in 2015. The ratio of Clinical Cardiologists to Cardiac Rehabilitation Specialists was 94:1, and the ratio of Intervention Specialists to cardiac rehabilitation experts was 16:1. Cardiac rehabilitation activities and costs varied widely. Patient dropout rate in phase II was 12%. Several barriers were identified: financial crisis (83%), lack of skilled personnel (67%), deficient equipment (46%), inadequate areas (42%), and a reduced number of operating centres (38%). CRPs in Mexico are still in the process of maturing. Mexican CRP-centres have several strengths, like the quality of the education of the professionals and the multidisciplinary programs. However, the lack of referral of patients and the heterogeneity of procedures are still their main weaknesses. Copyright © 2016 Instituto Nacional de Cardiología Ignacio Chávez. Publicado por Masson Doyma México S.A. All rights reserved.

The relative influence of secondary versus primary prevention using the national cholesterol education program adult treatment panel II guidelines

NARCIS (Netherlands)

Goldman, L; Coxson, P; Hunink, MGM; Goldman, PA; Tosteson, ANA; Mittleman, M; Williams, L; Weinstein, MC

OBJECTIVES This study was undertaken to project the population-wide effect of full implementation of the Adult Treatment Panel (ATP) II guidelines of the National Cholesterol Education Program (NCEP). BACKGROUND The ATP II has proposed guidelines for cholesterol reduction, but the long-term

Majewski osteodysplastic primordial dwarfism type II (MOPD II): expanding the vascular phenotype.

Science.gov (United States)

Bober, Michael B; Khan, Nadia; Kaplan, Jennifer; Lewis, Kristi; Feinstein, Jeffrey A; Scott, Charles I; Steinberg, Gary K

2010-04-01

Majewski Osteodysplastic Primordial Dwarfism, Type II (MOPD II) is a rare, autosomal recessive disorder. Features include severe intrauterine growth retardation (IUGR), poor postnatal growth (adult stature approximately 100 cm), severe microcephaly, skeletal dysplasia, characteristic facial features, and normal or near normal intelligence. An Institutional Review Board (IRB) approved registry was created and currently follows 25 patients with a diagnosis of MOPD II. Based on previous studies, a neurovascular screening program was implemented and 13 (52%) of these patients have been found to have cerebral neurovascular abnormalities including moyamoya angiopathy and/or intracranial aneurysms. The typical moyamoya pathogenesis begins with vessel narrowing in the supraclinoid internal carotid artery, anterior cerebral (A1) or middle cerebral (M1) artery segments. The narrowing may predominate initially on one side, progresses to bilateral stenosis, with subsequent occlusion of the vessels and collateral formation. We present four patients who, on neurovascular screening, were found to have cerebrovascular changes. Two were asymptomatic, one presented with a severe headache and projectile vomiting related to a ruptured aneurysm, and one presented after an apparent decline in cognitive functioning. Analysis of the registry suggests screening for moyamoya disease be performed at the time of MOPD II diagnosis and at least every 12-18 months using MRA or computerized tomographic angiography (CTA). We believe this is imperative. If diagnosed early enough, re-vascularization and aneurysm treatment in skilled hands can be performed safely and prevent or minimize long-term sequelae in this population. Emergent evaluation is also needed when other neurologic or cardiac symptoms are present. (c) 2010 Wiley-Liss, Inc.

Experimental Engineering Section semiannual progress report, March 1-August 31, 1976. Volume 2. Biotechnology and environmental programs

Energy Technology Data Exchange (ETDEWEB)

Pitt, Jr., W. W.; Mrochek, J. E. [comps.

1978-03-01

This volume contains the progress report of the biotechnology and environmental programs in the Experimental Engineering Section of the Chemical Technology Division. Research efforts in these programs during this report period have been in five areas: (1) environmental research; (2) centrifugal analyzer development; (3) advanced analytical systems development; (4) bioengineering research; and (5) bioengineering development. Summaries of these programmatic areas are contained in Volume I.

Clinical and laboratory findings in patients with dengue associated with hepatopathy

Directory of Open Access Journals (Sweden)

Delso do Nascimento

2011-12-01

Full Text Available INTRODUCTION: Hepatic disorders caused by dengue infection may progress to severe manifestations, including mortality and morbidity. Cytokines are involved in it, such as the migration inhibitory factor of macrophages (MIF, tumor necrosis factor (TNF, natural killer cells (NK, B lymphocytes, and macrophages. METHODS: This study was carried out from January to April 2007 at a public hospital from the Federal University of Mato Grosso do Sul, Campo Grande, Brazil. Sixty-eight patients were studied concerning hepatic alterations, with 56 reported having classic dengue, 6 with hemorrhagic dengue grade I, and 6 with hemorrhagic dengue grade II. RESULTS: Among the 56 with classic dengue, 83.3% had aspartate aminotransferase (AST alterations, and 69.6% had altered alanine aminotransferase (ALT. For those with hemorrhagic dengue grade I, 100% had AST alterations, and 83.3% had altered ALT. All the patients with hemorrhagic dengue grade II had AST and ALT alterations. AST variations reached 22.0 and 907.0, with an average value of 164.6. For ALT, we found variations between 25.0 and 867.0, with an average value of 166.07. There had been statistical significance between dengue clinical shapes and hepatic function markers. CONCLUSIONS: We conclude that the infection was predominant in adults, females, and in those with low income and education. The liver enzymes were of larger amount in hemorrhagic dengue, but there was weak statistical evidence of the clinical manifestations and transaminases. Major signs and clinical symptoms were fever, headache, myalgia, arthralgia, weakness, severe pain behind the eyes, and rashes.

National Waste Terminal Storage Program: planning and control plan. Volume II. Plan description

International Nuclear Information System (INIS)

1977-05-01

Objective of the NWTS program planning and control plan is to provide the information necessary for timely and effective OWI management decisions. Purpose is to describe the concepts and techniques that will be utilized by OWI to establish structured, completely planned and controlled technical, cost, and schedule NWTS baselines from which performance or progress can be accurately measured

Editorial: a new direction for ALT-J

Directory of Open Access Journals (Sweden)

Gráinne Conole

2003-12-01

Full Text Available The Association for Learning Technology celebrated its tenth anniversary this year and it can now be said that learning technology is a recognized research field, with a growing body of researchers and associated conferences and journals. Over the past two years as an editorial team we have undertaken a review of the position of ALT-J in relation to other journals in the area and considered the nature and scope of the papers we publish. We continue to expand our list of referees and have provided them with more detailed review forms to help guide them when considering recommendations on submissions and to encourage detailed, critical (and hopefully! helpful feedback to authors. We would like to take this opportunity to thank all the referees for their involvement and commitment to the journal and for their continued work on refereeing papers. As part of the review process we will be moving to a new publisher, Taylor and Francis, commencing with Volume 12; this is, in part, driven by a desire to increase our international profile and readership, as well as seeking to have a better online presence including electronic access to all papers. We are, after all, a research journal on learning technologies! We are looking forward to taking the journal forward with Taylor and Francis but would also like to take this opportunity to thank our current publisher, University of Wales Press, for all their support and professional work over the years; it has been very good working with them.

"A case report of Pott’s disease with unusual involvement of two separate levels of spine and delayed progressive Kyphosis "

OpenAIRE

Rahimi Movaghar V

2001-01-01

In Pott’s disease (tuberculous spondylitis), involvement of two separate levels of spine is rare. Attention to stability of spine prevents delayed progressive kyphosis. A 12-year-old girl presented with neck pain, tenderness and swelling Imaging showed Cl—C2 and T9-T10 and destruction. Mild spastic paraparesis was noticed. Preoperative diagnosis was metastasis. T9, T10 and T11 laminectomy and cervical operations were done in 2 sessions. Both pathologic examinations confirmed tuberculosis. Alt...

LLUVIA-II: A program for two-dimensional, transient flow through partially saturated porous media

International Nuclear Information System (INIS)

Eaton, R.R.; Hopkins, P.L.

1992-08-01

LLUVIA-II is a program designed for the efficient solution of two- dimensional transient flow of liquid water through partially saturated, porous media. The code solves Richards equation using the method-of-lines procedure. This document describes the solution procedure employed, input data structure, output, and code verification

Majewski osteodysplastic primordial dwarfism type II (MOPD II): natural history and clinical findings.

Science.gov (United States)

Hall, Judith G; Flora, Christina; Scott, Charles I; Pauli, Richard M; Tanaka, Kimi I

2004-09-15

A description of the clinical features of Majewski osteodysplastic primordial dwarfism type II (MOPD II) is presented based on 58 affected individuals (27 from the literature and 31 previously unreported cases). The remarkable features of MOPD II are: severe intrauterine growth retardation (IUGR), severe postnatal growth retardation; relatively proportionate head size at birth which progresses to true and disproportionate microcephaly; progressive disproportion of the short stature secondary to shortening of the distal and middle segments of the limbs; a progressive bony dysplasia with metaphyseal changes in the limbs; epiphyseal delay; progressive loose-jointedness with occasional dislocation or subluxation of the knees, radial heads, and hips; unusual facial features including a prominent nose, eyes which appear prominent in infancy and early childhood, ears which are proportionate, mildly dysplastic and usually missing the lobule; a high squeaky voice; abnormally, small, and often dysplastic or missing dentition; a pleasant, outgoing, sociable personality; and autosomal recessive inheritance. Far-sightedness, scoliosis, unusual pigmentation, and truncal obesity often develop with time. Some individuals seem to have increased susceptibility to infections. A number of affected individuals have developed dilation of the CNS arteries variously described as aneurysms and Moya Moya disease. These vascular changes can be life threatening, even in early years because of rupture, CNS hemorrhage, and strokes. There is variability between affected individuals even within the same family. Copyright 2004 Wiley-Liss, Inc.

Advanced research and technology development fossil energy materials program. Quarterly progress report for the period ending September 30, 1981

Energy Technology Data Exchange (ETDEWEB)

Bradley, R.A. (comp.)

1981-12-01

This is the fourth combined quarterly progress report for those projects that are part of the Advanced Research and Technology Development Fossil Energy Materials Program. The objective is to conduct a program of research and development on materials for fossil energy applications with a focus on the longer-term and generic needs of the various fossil fuel technologies. The program includes research aimed toward a better understanding of materials behavior in fossil energy environments and the development of new materials capable of substantial enhancement of plant operations and reliability. Work performed on the program generally falls into the Applied Research and Exploratory Development categories as defined in the DOE Technology Base Review, although basic research and engineering development are also conducted. A substantial portion of the work on the AR and TD Fossil Energy Materials Program is performed by participating cntractor organizations. All subcontractor work is monitored by Program staff members at ORNL and Argonne National Laboratory. This report is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FY 1981 in which projects are organized according to fossil energy technologies. We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program.

CASUÍSTICA DE ALTE NUM HOSPITAL TERCIÁRIO – O QUE MUDOU NOS ÚLTIMOS 5 ANOS?

Directory of Open Access Journals (Sweden)

Daniel Meireles

2016-07-01

Conclusões: O ALTE cursa frequentemente com evolução favorável. Apesar de não haver recomendação ou consensos na literatura para a investigação etiológica, esta mantém-se uma prática comum, sem aparente modificação na abordagem nos últimos anos, em comparação com estudo prévio realizado em 2009.

MUSICAL RADIO: THE TECHNOLOGY OF PROGRAMING

Directory of Open Access Journals (Sweden)

Bysko Maxim

2016-12-01

Full Text Available The author considers the musical radio broadcasting of the XX-XXI centuries from the point of view of a technical progress. He covers the period from "before tape" era and "tape" era to the modern digital media broadcasting (as example with the Digispot II broadcast automation software. However, despite the significant changes in technics, which are expressed primarily in the extensive use of a computer automation and reduction of programming staff (often up to two or three persons: a program director, a managing editor, a music editor, the principles of the linear broadcasting structure remained identical as a whole. So, the basic structural units here are the program blocks, "clocks", blocks of clock's elements (today, these elements often filled with automated rotation.

Progress report of a research program in experimental high-energy physics, 1 January 1983-31 December 1983

International Nuclear Information System (INIS)

Widgoff, M.; Shapiro, A.M.

1983-01-01

An experimental program to study the interactions of hadrons and photons is being carried out using hybrid systems which include bubble chambers as visible targets as well as counter spectrometers for particle detection, measurement and identification. Experiments are now being carried out at Fermilab and SLAC, and an experiment on neutrino interactions has been approved for the Tevatron at Fermilab. We have been analyzing the film of our one-million-picture 1982 exposure for the study of π/sup +-/, K + and p interactions in hydrogen and in magnesium, silver and gold, at a beam momentum of 200 Gev/c (FNAL Experiments E-565 and E-570). Preliminary results confirm the positive charge excess observed among relativistic particles in our test run of 1981. During the past year analysis has continued on the data of SLAC experiments BC 72/73, investigating the interactions with hydrogen of 20 GeV polarized photons. Results have been obtained and published on the photoproduction of charm and on the lifetimes of charmed particles. Analysis is also in progress on production of vector mesons and strange particles. The study of charm photoproduction and decay is being extended in SLAC experiment BC 75. An initial run of over 600,000 pictures was obtained in the SLAC Hybrid Facility in Spring 1983 with substantially improved resolution in the bubble chamber. Extensive work continues on the analysis of our earlier FNAL experiments on π/sup +-/p, K + p, and pp interactions at 147 GeV/c (FNAL Experiment E-299). Preparations are in progress for our approved Tevatron II experiment designed to study neutrino interactions and particularly the production of tau neutrinos, using a neutrino beam produced by beam dump techniques and employing a hybrid system with a new one-meter holographic bubble chamber

Annual Program Progress Report under DOE/PHRI Cooperative Agreement: (July 1, 2001-June 30, 2002)

Energy Technology Data Exchange (ETDEWEB)

Palafox, Neal A., MD, MPH

2002-07-31

OAK B188 DOE/PHRI Special Medical Care Program in the Republic of the Marshall Islands (RMI)Annual Program Progress Report. The DOE Marshall Islands Medical Program continued, in this it's 48th year, to provide medical surveillance for the exposed population from Rongelap and Utrik and the additional DOE patients. The program was inaugurated in 1954 by the Atomic Energy Commission following the exposure of Marshallese to fallout from a nuclear test (Castle Bravo) at Bikini Atoll. This year marks the fourth year in which the program has been carried out by PHRI under a cooperative agreement with DOE. The DOERHRI Special Medical Care Program, awarded the cooperative agreement on August 28, 1998, commenced its health care program on January 15, 1999, on Kwajalein and January 22, 1999, on Majuro. This report details the program for the July 1, 2001, through the June 30, 2002, period. The program provides year-round, on-site medical care to the DOE patient population residing in the Republic of the Marshall Islands (RMI) and annual examinations to those patients living in Hawaii and on the Continental U.S.

Accelerator Technology Program. Progress report, January-June 1980

International Nuclear Information System (INIS)

Knapp, E.A.; Jameson, R.A.

1980-03-01

The activities of Los Alamos Scientific Laboratory's (LASL) Accelerator Technology (AT) Division during the first six months of calendar 1980 are discussed. This report is organized around major projects of the Division, reflecting a wide variety of applications and sponsors. The first section summarizes progress on the Proton Storage Ring to be located between LAMPF and the LASL Pulsed Neutron Research facility, followed by a section on the gyrocon, a new type of high-power, high-efficiency radio-frequency (rf) amplifier. The third section discusses the racetrack microtron being developed jointly by AT Division and the National Bureau of Standards; the fourth section concerns the free-electron studies. The fifth section covers the radio-frequency quadrupole linear accelerator, a new concept for the acceleration of low-velocity particles; this section is followed by a section discussing heavy ion fusion accelerator development. The next section reports activities in the Fusion Materials Irradiation Test program, a collaborative effort with the Hanford Engineering Development Laboratory. The final section deals first with development of H - ion sources and injectors, then with accelerator instrumentation and beam dynamics

Frank and Fearless: Supporting Academic Career Progression for Women in an Australian Program

OpenAIRE

Polly Parker; Belinda Hewitt; Jennifer Witheriff; Amy Cooper

2018-01-01

The underrepresentation of women in senior positions continues to be a major challenge in higher education and most other industries. In Australia, the career trajectory for academic women stalls at a lower level than that of their male counterparts. Concern about this situation in one Australian university led to the design and delivery of a career progression program to support women’s advancement from senior lecturer to associate professor. This study details the main features of the progr...

Progress report - reports on reactor safety research programs sponsored by the Federal Ministry for Research and Technology

International Nuclear Information System (INIS)

1982-09-01

Each progress report represents a compilation of individual reports about objectives, the work performed, the results, the next steps of the work etc. The individual reports are prepared in a standard form by the contractors themselves as a documentation of their progress in work and published by the GRS, within the framework of general information of progress in reactor safety research. The individual reports are classified according to the research program on the safety of LWRs 1977-1980 of the BMFT. Another table of contents uses the same classification system as applied in the nuclear safety index of the CEC and the OECD. The reports are arranged in the sequence of their project numbers. (orig./HP) [de

Micellar effect on metal-ligand complexes of Co(II, Ni(II, Cu(II and Zn(II with citric acid

Directory of Open Access Journals (Sweden)

Nageswara Rao Gollapalli

2009-12-01

Full Text Available Chemical speciation of citric acid complexes of Co(II, Ni(II, Cu(II and Zn(II was investigated pH-metrically in 0.0-2.5% anionic, cationic and neutral micellar media. The primary alkalimetric data were pruned with SCPHD program. The existence of different binary species was established from modeling studies using the computer program MINIQUAD75. Alkalimetric titrations were carried out in different relative concentrations (M:L:X = 1:2:5, 1:3:5, 1:5:3 of metal (M to citric acid. The selection of best chemical models was based on statistical parameters and residual analysis. The species detected were MLH, ML2, ML2H and ML2H2. The trend in variation of stability constants with change in mole fraction of the medium is explained on the basis of electrostatic and non-electrostatic forces. Distributions of the species with pH at different compositions of micellar media are also presented.

Status and progress of the RERTR program in the year 2003

International Nuclear Information System (INIS)

Travelli, Armando

2003-01-01

One of the most important events affecting the RERTR program during the past year was the decision by the U.S. Department of Energy to request the U.S. Congress to significantly increase RERTR program funding. This decision was prompted, at least in part, by the terrible events of September 11, 2001, and by a high-level U.S./Russian Joint Expert Group recommendation to immediately accelerate RERTR program activities in both countries, with the goal of converting all the world's research reactors to low-enriched fuel at the earliest possible time, and including both Soviet-designed and United States-designed research reactors. The U.S. Congress is expected to approve this request very soon, and the RERTR program has prepared itself well for the intense activities that the 'Accelerated RERTR Program' will require. Promising results have been obtained in the development of a fabrication process for monolithic LEU U-Mo fuel. Most existing and future research reactors could be converted to LEU with this fuel, which has a uranium density between 15.4 and 16.4 g/cm 3 and yielded promising irradiation results in 2002. The most promising method hinges on producing the monolithic meat by cold-rolling a thin ingot produced by casting. The aluminum clad and the meat are bonded by friction stir welding and the cladding surface is finished by a light cold roll. This method can be applied to the production of miniplates and appears to be extendable to the production of full-size plates, possibly with intermediate anneals. Other methods planned for investigation include high temperature bonding and hot isostatic pressing. The progress achieved within the Russian RERTR program, both for the traditional tube-type elements and for the new 'universal' LEU U-Mo pin-type elements, promises to enable soon the conversion of many Russian-designed research and test reactors. Irradiation testing of both fuel types with LEU U-Mo dispersion fuels has begun. Detailed studies are in progress to

Hydrologic resources management program, FY 1998 progress report; FINAL

International Nuclear Information System (INIS)

Benedict, F.C.; Criss, R.E.; Davisson, M.L.; Eaton, G.F.; Hudson, G.B.; Kenneally, J.M.; Rose, T.P.; Smith, D.

1999-01-01

This report presents the results from FY 1998 technical studies conducted by Lawrence Livermore National Laboratory (LLNL) as part of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area (UGTA) project. The HRMP is sponsored by Defense Programs (DP) of the U.S. Department of Energy, Nevada Operations Office (DOE/NV), and supports DP operations at the Nevada Test Site (NTS) through studies of radiochemistry and resource management related to the defense programs mission. Other participating organizations include the Los Alamos National Laboratory (LANL), the United States Geological Survey (USGS), the Desert Research Institute (DRI) of the University of Nevada, the United States Environmental Protection Agency (EPA), and Bechtel-Nevada (BN). The UGTA project is an Environmental Management (EM) activity of DOE/NV that supports a Federal Facilities Agreement and Consent Order between the Department of Energy, the Department of Defense, and the State of Nevada. UGTA's primary function is to address the legacy release of hazardous constituents at the Nevada Test Site, the Tonopah Test Range, and off-Nevada Test Site underground nuclear testing areas. Participating contractors include LLNL (Earth and Environmental Sciences Directorate, Analytical and Nuclear Chemistry Division), LANL, DRI, USGS, BN, HSI-GeoTrans, and IT Corporation. The FY 1998 HRMP and UGTA annual progress report follows the organization and contents of our FY 1997 report (Smith et al., 1998), and includes our results from CY 1997-1998 technical studies of radionuclide migration and isotope hydrology at the Nevada Test Site. During FY 1998, LLNL continued its efforts under the HRMP to pursue a technical agenda relevant to the science-based stockpile stewardship program at DOE/NV. Support to UGTA in FY 1998 included efforts to quantitatively define the radionuclide source term residual from underground nuclear weapons testing and the derivative solution, or hydrologic source

Student science enrichment training program. Progress report, June 1, 1991--May 31, 1992

Energy Technology Data Exchange (ETDEWEB)

Sandhu, S.S.

1992-04-21

Historically Black Colleges and Universities wing of the United States Department of Energy (DOE) provided funds to Claflin College, Orangeburg, S.C. To conduct a student Science Enrichment Training Program for a period of six weeks during 1991 summer. Thirty participants were selected from a pool of applicants, generated by the High School Seniors and Juniors and the Freshmen class of 1990-1991 at Claflin College. The program primarily focused on high ability students, with potential for Science, Mathematics and Engineering Careers. The major objectives of the program were W to increase the pool of well qualified college entering minority students who will elect to go in Physical Sciences and Engineering and (II) to increase the enrollment in Chemistry and Preprofessional-Pre-Med, Pre-Dent, etc.-majors at Claflin College by including the Claflin students to participate in summer academic program. The summer academic program consisted of Chemistry and Computer Science training. The program placed emphasis upon laboratory experience and research. Visits to Scientific and Industrial laboratories were arranged. Guest speakers which were drawn from academia, industry and several federal agencies, addressed the participants on the future role of Science in the industrial growth of United States of America. The guest speakers also acted as role models for the participants. Several videos and films, emphasizing the role of Science in human life, were also screened.

Fossil Energy Program Annual Progress Report for the Period April 1, 2000 through March 31, 2001

Energy Technology Data Exchange (ETDEWEB)

Judkins, RR

2001-06-14

This report covers progress made at Oak Ridge National Laboratory (ORNL) on research and development projects that contribute to the advancement of fossil energy technologies. Projects on the ORNL Fossil Energy Program are supported by the U.S. Department of Energy (DOE) Office of Fossil Energy, the DOE National Energy Technology Laboratory (NETL), the DOE Fossil Energy Clean Coal Technology (CCT) Program, the DOE National Petroleum Technology Office, and the DOE Fossil Energy Office of Strategic Petroleum Reserve (SPR). The ORNL Fossil Energy Program research and development activities cover the areas of coal, clean coal technology, gas, petroleum, and support to the SPR. An important part of the Fossil Energy Program is technical management of all activities on the DOE Fossil Energy Advanced Research (AR) Materials Program. The AR Materials Program involves research at other DOE and government laboratories, at universities, and at industrial organizations.

Short-rotation woody-crops program. Quarterly progress report for period ending May 31, 1981

Energy Technology Data Exchange (ETDEWEB)

Cushman, J.H.; Ranney, J.W.

1982-04-01

Progress of twenty projects in the Short Rotation Woody Crops Program is summarized for the period March 1 through May 31, 1981. Individual quarterly reports included from each of the projects discuss accomplishments within specific project objectives and identify recent papers and publications resulting from the research. The major project activities are species screening and genetic selection, stand establishment and cultural treatment, and harvest, collection, transportation, and storage.

A user`s guide to LUGSAN II. A computer program to calculate and archive lug and sway brace loads for aircraft-carried stores

Energy Technology Data Exchange (ETDEWEB)

Dunn, W.N. [Sandia National Labs., Albuquerque, NM (United States). Mechanical and Thermal Environments Dept.

1998-03-01

LUG and Sway brace ANalysis (LUGSAN) II is an analysis and database computer program that is designed to calculate store lug and sway brace loads for aircraft captive carriage. LUGSAN II combines the rigid body dynamics code, SWAY85, with a Macintosh Hypercard database to function both as an analysis and archival system. This report describes the LUGSAN II application program, which operates on the Macintosh System (Hypercard 2.2 or later) and includes function descriptions, layout examples, and sample sessions. Although this report is primarily a user`s manual, a brief overview of the LUGSAN II computer code is included with suggested resources for programmers.

Reference methodologies for radioactive controlled discharges an activity within the IAEA's Program Environmental Modelling for Radiation Safety II (EMRAS II)

International Nuclear Information System (INIS)

Stocki, T.J.; Bergman, L.; Tellería, D.M.; Proehl, G.; Amado, V.; Curti, A.; Bonchuk, I.; Boyer, P.; Mourlon, C.; Chyly, P.; Heling, R.; Sági, L.; Kliaus, V.; Krajewski, P.; Latouche, G.; Lauria, D.C.; Newsome, L.; Smith, J.

2011-01-01

In January 2009, the IAEA EMRAS II (Environmental Modelling for Radiation Safety II) program was launched. The goal of the program is to develop, compare and test models for the assessment of radiological impacts to the public and the environment due to radionuclides being released or already existing in the environment; to help countries build and harmonize their capabilities; and to model the movement of radionuclides in the environment. Within EMRAS II, nine working groups are active; this paper will focus on the activities of Working Group 1: Reference Methodologies for Controlling Discharges of Routine Releases. Within this working group environmental transfer and dose assessment models are tested under different scenarios by participating countries and the results compared. This process allows each participating country to identify characteristics of their models that need to be refined. The goal of this working group is to identify reference methodologies for the assessment of exposures to the public due to routine discharges of radionuclides to the terrestrial and aquatic environments. Several different models are being applied to estimate the transfer of radionuclides in the environment for various scenarios. The first phase of the project involves a scenario of nuclear power reactor with a coastal location which routinely (continuously) discharges 60Co, 85Kr, 131I, and 137Cs to the atmosphere and 60Co, 137Cs, and 90Sr to the marine environment. In this scenario many of the parameters and characteristics of the representative group were given to the modelers and cannot be altered. Various models have been used by the different participants in this inter-comparison (PC-CREAM, CROM, IMPACT, CLRP POSEIDON, SYMBIOSE and others). This first scenario is to enable a comparison of the radionuclide transport and dose modelling. These scenarios will facilitate the development of reference methodologies for controlled discharges. (authors)

VERIFIKASI PAKET PROGRAM MVP-II DAN SRAC2006 PADA KASUS TERAS REAKTOR VERA BENCHMARK.

Directory of Open Access Journals (Sweden)

Jati Susilo

2015-03-01

Full Text Available Dalam penelitian ini dilakukan verifikasi perhitungan benchmark VERA pada kasus Zero Power Physical Test (ZPPT teras reaktor Watts Bar 1. Reaktor tersebut merupakan jenis PWR kelas 1000 MWe yang didesain oleh Westinghouse, tersusun dari 193 perangkat bahan bakar 17×17 dengan 3 jenis pengkayaan UO2 yaitu 2,1wt%, 2,619wt% dan 3,1wt%. Perhitungan nilai k-eff dan distribusi faktor daya dilakukan pada siklus operasi pertama teras dengan kondisi beginning of cycle (BOC dan hot zero power (HZP. Posisi batang kendali dibedakan menjadi uncontrolled (semua batang kendali berada di luar teras, dan controlled (batang kendali Bank D didalam teras. Paket program komputer yang digunakan dalam perhitungan adalah MVP-II dan SRAC2006 modul CITATION dengan data pustaka tampang lintang ENDF/B-VII.0. Hasil perhitungan menunjukkan bahwa perbedaan nilai k-eff teras pada kondisi controlled dan uncontrolled antara referensi dengan MVP-II (-0,07% dan -0,014% dan SRAC2006 (0,92% dan 0,99% sangat kecil atau masih dibawah 1%. Perbedaan faktor daya maksimum teras pada kondisi controlled dan uncontrolled dengan referensi dengan MVP-II adalah 0,38% dan 1,53%, sedangkan dengan SRAC2006 adalah 1,13% dan -2,45%. Dapat dikatakan bahwa kedua paket program komputer menunjukkan hasil perhitungan yang sesuai dengan nilai referensi. Dalam hal penentuan kekritisan teras, maka hasil perhitungan MVP-II lebih konservatif dibandingkan dengan SRAC2006. Kata kunci : MVP-II, SRAC2006, PWR, VERA   In this research, verification calculation for VERA core physics benchmark on the Zero Power Physical Test (ZPPT of the nuclear reactor Watts Bar 1. The reactor is a 1000 MWe class of PWR designed by Westinghouse, arranged from 193 unit of 17×17 fuel assembly consisting 3 type enrichment of UO2 that are 2.1wt%, 2.619wt% and 3.1wt%. Core power factor distribution and k-eff calculation has been done for the first cycle operation of the core at beginning of cycle (BOC and hot zero power (HZP. In this

Waste Tank Organic Safety Program: Analytical methods development. Progress report, FY 1994

International Nuclear Information System (INIS)

Campbell, J.A.; Clauss, S.A.; Grant, K.E.

1994-09-01

The objectives of this task are to develop and document extraction and analysis methods for organics in waste tanks, and to extend these methods to the analysis of actual core samples to support the Waste Tank organic Safety Program. This report documents progress at Pacific Northwest Laboratory (a) during FY 1994 on methods development, the analysis of waste from Tank 241-C-103 (Tank C-103) and T-111, and the transfer of documented, developed analytical methods to personnel in the Analytical Chemistry Laboratory (ACL) and 222-S laboratory. This report is intended as an annual report, not a completed work

Simulation and interpretation of ion beam diagnostics on PBFA-II

International Nuclear Information System (INIS)

Mehlhorn, T.A.; Nelson, W.E.; Maenchen, J.E.; Stygar, W.A.; Ruiz, C.L.; Lockner, T.R.; Johnson, D.J.

1988-03-01

Ion diode and beam focusing experiments are in progress on PBFA-II working towards an ultimate goal of significant burn of an ICF pellet. Beam diagnostics on these experiments include a Thomson parabola, K/sub alpha/ x-ray pinhole cameras, filtered ion pinhole cameras, and a magnetic spectrometer. We are developing two new computer programs to simulate and interpret the data obtained from these diagnostics. VIDA is a VAX-based program that manipulates and unfolds data from digitized particle and x-ray diagnostic images. VIDA operations include: image display, background substraction, relative-to-absolute coordinate transformations, and image projection into the beam reference frame. PICDIAG allows us to study the effects of time-dependent ion focusing on the performance of ion beam diagnostics. 10 refs., 5 figs

Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study.

Science.gov (United States)

Catanzaro, Daniele; Shackney, Stanley E; Schaffer, Alejandro A; Schwartz, Russell

2016-01-01

Ductal Carcinoma In Situ (DCIS) is a precursor lesion of Invasive Ductal Carcinoma (IDC) of the breast. Investigating its temporal progression could provide fundamental new insights for the development of better diagnostic tools to predict which cases of DCIS will progress to IDC. We investigate the problem of reconstructing a plausible progression from single-cell sampled data of an individual with synchronous DCIS and IDC. Specifically, by using a number of assumptions derived from the observation of cellular atypia occurring in IDC, we design a possible predictive model using integer linear programming (ILP). Computational experiments carried out on a preexisting data set of 13 patients with simultaneous DCIS and IDC show that the corresponding predicted progression models are classifiable into categories having specific evolutionary characteristics. The approach provides new insights into mechanisms of clonal progression in breast cancers and helps illustrate the power of the ILP approach for similar problems in reconstructing tumor evolution scenarios under complex sets of constraints.

Energy Extension Service Pilot Program: evaluation report after two years. Volume II. State reports

Energy Technology Data Exchange (ETDEWEB)

None

1980-04-01

This report, Vol. II, presents a discussion of the operations of the ten EES pilot state programs during the period from October 1, 1977 through September 30, 1979. Each of the ten pilot states - Alabama, Connecticut, Michigan, New Mexico, Pennsylvania, Tennessee, Texas, Washington, Wisconsin, and Wyoming - received a grant of approximately $1.1 million to develop and implement an 18-month program beginning on October 1, 1977. In September 1978, each State received an additional $370,000 for service-delivery programs for the extension of the pilot program, April 1979 through September 1979. A case-study description of the operations of the pilot program in each State is provided here, with special attention given to the two programs selected in each State for more-detailed study and survey research. Although the thrust of this volume is descriptive, some survey data and analyses are presented for the emphasis programs. Two telephone surveys of clients and a non-client sample were conducted, one at the end of the first year of the pilot program (October 1977 - September 1978) and one at the end of the second year (October 1978 - September 1979).

Internationalisering og progression

DEFF Research Database (Denmark)

Wilken, Lisanne; Tange, Hanne

2014-01-01

means that programs can attract students from outside Denmark, and these students often come from different academic backgrounds. To investigate how these changes are affecting the way professors who teach on interdisciplinary international masters programs conceive student progress, we carried out semi...

38 CFR 21.7653 - Progress, conduct, and attendance.

Science.gov (United States)

2010-07-01

... on which the school official who is responsible for determining whether a student is making progress...) Satisfactory pursuit of program. In order to receive educational assistance for pursuit of a program of education, a reservist must maintain satisfactory progress. Progress is unsatisfactory if the reservist does...

Communication of nuclear data progress: No.9 (1993)

International Nuclear Information System (INIS)

1993-06-01

The is the ninth issue of > (CNDP), in which the nuclear data progress in China during the passed year is carried. It includes optical model parameters for both small angles and larger angles elastic scattering, n-T phase shift analyses, forbidden angular region of secondary particle emission, introduction to codes CMUP2 and CFUP1, diffusion process of nuclear fission, techniques used for charged particle evaluation at CNDC, evaluation of neutron nuclear data for 7 Li and revision on recommended data of 238 U for CENDL-2, Chinese Evaluated Nuclear Parameter Library (CENPL) (II) and computer program library at CNDC, covariance data evaluation for experimental data and several examples of least squares combination for derived data, and calculation of thermal neutron scattering law for anisotropic microcrystals etc

TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan.

Science.gov (United States)

Iwayanagi, Takao; Miyamoto, Sei; Konno, Takeshi; Mizutani, Hisashi; Hirai, Tomohiro; Shigemoto, Yasumasa; Gojobori, Takashi; Sugawara, Hideaki

2012-09-01

The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index_e.html .

An integrated program of geophysical survey, coring, and test excavations to study a 4th millennium bc-cal ditch at Alt del Punxó (Muro de L’alcoi, Alacant

Directory of Open Access Journals (Sweden)

García Puchol, Otero

2008-06-01

Full Text Available The potentially long and interesting archaeological sequence revealed by systematic survey at the site of Alt Del Punxó (Muro de l’Alcoi, Alacant was the basis for initiating a study of the locality’s subsurface structures using new methods of remote sensing. Geophysical survey (magnetometry and tomography and systematic augering revealed buried structures, including monumental earthworks, and guided subsequent excavations to collect more detailed data about the nature and age of these prehistoric features. The information recovered, including new radiocarbon dates, offers a new perspective on the organization of prehistoric populations in this region of south-central Valencia since the beginning of the Holocene and is especially important for understanding the Neolithic IIB from the 4th through the early 3rd Millennium BC.

La amplia e interesante secuencia arqueológica sugerida por los materiales de superficie del yacimiento de Alt del Punxó (Muro de l’Alcoi, Alacant ha supuesto el punto de partida para la práctica de una serie de métodos de detección de las estructuras conservadas en el lugar. La prospección geofísica (magnetometría y tomografía, y los microsondeos (augers han dirigido la planificación de la excavación con el fin de obtener nuevos datos a propósito de la naturaleza y cronología del gran foso prehistórico, así como de las diversas estructuras localizadas. La información obtenida, junto a la serie radiocarbónica disponible, abre nuevas perspectivas para el estudio del poblamiento prehistórico al aire libre en las comarcas centro-meridionales valencianas desde los inicios del Holoceno, y de un modo particular en el IV e inicios del III milenio cal AC –Neolítico IIB.

Experimental and theoretical high energy physics research. Annual progress report, September 1, 1991--September 31, 1992

Energy Technology Data Exchange (ETDEWEB)

1992-10-01

Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics; (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R & D.

Changes of serum levels of prealbumin (PAB), cholinesterase (CHE), total bile acid (TBA) and ALT as related to the severity of inflammatory process and hepatic fibrosis in patients with chronic virus B hepatitis

International Nuclear Information System (INIS)

Chi Xiaoxia; Chen Jianxiong; Xiong Ying

2005-01-01

Objective: To study the correlationship between the serum levels of PAB, CHE, TBA, ALT and the severity of the disease process in patients with chronic virus B hepatitis. Methods: Serum levels of PAB, CHE, ALT (with biochemical methods) and TBA (with RIA) were examined in 93 patients with biopsy proven virus B hepatitis and 46 controls. Results: The 93 patients were of two groups: a less advanced group (n=51) and a more advanced group (n=42). Serum TBA, ALT levels were significnatly higher and serum PAB, CHE levels were significantly lower in the more advanced group than those in the less advanced group (P 0 to s 4 . Changes of levels of ALT were of no regular pattern, but serum levels of TBA regularly increased and levels of PAB, CHE regularly decreased as the fibrosis grading proceeded from s 0 to s 4 and the differences between the levels in s 4 and any other grading were significant (P<0.01). Conclusion: Combined determination of these serum markers might reflect the degree of inflammatory process and hepatic fibrosis in patients with virus B hepatitis, leading to earlier detection of cirrhosis. (authors)

Waste Isolation Safety Assessment Program. Technical progress report for FY-1978

International Nuclear Information System (INIS)

Brandstetter, A.; Harwell, M.A.; Howes, B.W.; Benson, G.L.; Bradley, D.J.; Raymond, J.R.; Serne, R.J.; Schilling, A.H.

1979-07-01

Associated with commercial nuclear power production in the United States is the generation of potentially hazardous radioactive wastes. The Department of Energy (DOE) is seeking to develop nuclear waste isolation systems in geologic formations that will preclude contact with the biosphere of waste radionuclides in concentrations which are sufficient to cause deleterious impact on humans or their environments. Comprehensive analyses of specific isolation systems are needed to assess the expectations of meeting that objective. The Waste Isolation Safety Assessment Program (WISAP) has been established at the Pacific Northwest Laboratory (operated by Battelle Memorial Institute) for developing the capability of making those analyses. Progress on the following tasks is reported: release scenario analysis, waste form release rate analysis, release consequence analysis, sorption-desorption analysis, and societal acceptance analysis

Experimental particle physics at the University of Pittsburgh. Progress report, November 1, 1995--October 31, 1996

Energy Technology Data Exchange (ETDEWEB)

Boudreau, J.F.; Engels, E. Jr.; Shepard, P.F.; Thompson, J.A.

1996-05-01

This report covers the progress on two different tasks, Task A and Task B. Task A focuses on rare and semi-rare decays of {phi} and of the short-lived kaon with emphasis on those aspects needed in preparation for the proposed {Phi}-Factory measurements of CPT violation and {epsilon}{prime}/{epsilon} from the CP-violating decays of the K{sub L}K{sub S} final state. The second aspect of the kaon decay work is participation in the so-called rare kaon decay experiments, E865, at BNL. The major goals of Task B, Fermilab program, are as follows: (1) participation in the analysis of the E706 data taken during the 1990--1991 fixed target run at Fermilab and (2) the continuation of the work with the CDF collaboration particularly the SVX II upgrade. The E706 part of the program involves the completion of publications reporting the results of the 1990--91 data run. The analysis of these data is now mature and physics results are emerging. The CDF program involves a dedicated effort to the design of a silicon vertex detector upgrade, SVX II, to be accomplished by the time Fermilab run II collider run (1999). In addition they are participating in the 1993--1995 collide run Ib and actively analyzing the data from both runs Ia and Ib.

Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer.

Science.gov (United States)

Carneiro, Marcella Lemos Brettas; Peixoto, Raphael C A; Joanitti, Graziela A; Oliveira, Ricardo G S; Telles, Luis A M; Miranda-Vilela, Ana L; Bocca, Anamélia L; Vianna, Leonora M S; da Silva, Izabel C R; de Souza, Aparecido R; Lacava, Zulmira G M; Báo, Sônia N

2013-02-16

Magnetic fluids containing superparamagnetic iron oxide nanoparticles represent an attractive platform as nanocarriers in chemotherapy. Recently, we developed a formulation of maghemite nanoparticles coated with rhodium (II) citrate, which resulted in in vitro cytotoxicity enhanced up to 4.6 times when compared to free rhodium (II) citrate formulation on breast carcinoma cells. In this work, we evaluate the antitumor activity and toxicity induced by these formulations in Balb/c mice bearing orthotopic 4T1 breast carcinoma. Mice were evaluated with regard to the treatments' toxicity through analyses of hemogram, serum levels of alanine aminotransferase, iron, and creatinine; DNA fragmentation and cell cycle of bone marrow cells; and liver, kidney and lung histology. In addition, the antitumor activity of rhodium (II) citrate and maghemite nanoparticles coated with rhodium (II) citrate was verified by tumor volume reduction, histology and immunohistochemistry. Regarding the treatments' toxicity, no experimental groups had alterations in levels of serum ALT or creatinine, and this suggestion was corroborated by the histopathologic examination of liver and kidney of mice. Moreover, DNA fragmentation frequency of bone marrow cells was lower than 15% in all experimental groups. On the other hand, the complexes rhodium (II) citrate-functionalized maghemite and free rhodium (II) citrate led to a marked growth inhibition of tumor and decrease in CD31 and Ki-67 staining. In summary, we demonstrated that both rhodium (II) citrate and maghemite nanoparticles coated with rhodium (II) citrate formulations exhibited antitumor effects against 4T1 metastatic breast cancer cell line following intratumoral administration. This antitumor effect was followed by inhibition of both cell proliferation and microvascularization and by tumor tissue injury characterized as necrosis and fibrosis. Remarkably, this is the first published report demonstrating the therapeutic efficacy of maghemite

Design for energy efficiency: Energy efficient industrialized housing research program. Progress report

Energy Technology Data Exchange (ETDEWEB)

Kellett, R.; Berg, R.; Paz, A.; Brown, G.Z.

1991-03-01

Since 1989, the U.S. Department of Energy has sponsored the Energy Efficient Industrialized Housing research program (EEIH) to improve the energy efficiency of industrialized housing. Two research centers share responsibility for this program: The Center for Housing Innovation at the University of Oregon and the Florida Solar Energy Center, a research institute of the University of Central Florida. Additional funding is provided through the participation of private industry, state governments and utilities. The program is guided by a steering committee comprised of industry and government representatives. This report summarizes Fiscal Year (FY) 1990 activities and progress, and proposed activities for FY 1991 in Task 2.1 Design for Energy Efficiency. This task establishes a vision of energy conservation opportunities in critical regions, market segments, climate zones and manufacturing strategies significant to industrialized housing in the 21st Century. In early FY 1990, four problem statements were developed to define future housing demand scenarios inclusive of issues of energy efficiency, housing design and manufacturing. Literature surveys were completed to assess seven areas of influence for industrialized housing and energy conservation in the future. Fifty-five future trends were identified in computing and design process; manufacturing process; construction materials, components and systems; energy and environment; demographic context; economic context; and planning policy and regulatory context.

Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy

Science.gov (United States)

Drappatz, Jan; de Groot, John; Prados, Michael D; Reardon, David A; Schiff, David; Chamberlain, Marc; Mikkelsen, Tom; Desjardins, Annick; Holland, Jaymes; Ping, Jerry; Weitzman, Ron; Cloughesy, Timothy F

2018-01-01

Abstract Background Cabozantinib is a tyrosine kinase inhibitor with activity against vascular endothelial growth factor receptor 2 (VEGFR2) and MET that has demonstrated clinical activity in advanced solid tumors. This open-label, phase II trial evaluated cabozantinib in patients with recurrent or refractory glioblastoma (GBM). Methods Patients were initially enrolled at a starting dose of 140 mg/day, but the starting dose was amended to 100 mg/day because of toxicity. Treatment continued until disease progression or unacceptable toxicity. The primary endpoint was objective response rate assessed by an independent radiology facility using modified Response Assessment in Neuro-Oncology criteria. Additional endpoints included duration of response, 6-month and median progression-free survival, overall survival, and safety. Results Among 152 patients naive to prior antiangiogenic therapy, the objective response rate was 17.6% and 14.5% in the 140 mg/day and 100 mg/day groups, respectively, which did not meet the predefined statistical target for success. The proportions of patients alive and progression free at 6 months were 22.3% and 27.8%, respectively. Median progression-free survival was 3.7 months in both groups, and median overall survival was 7.7 months and 10.4 months, respectively. The incidence of grade 3/4 adverse events (AEs) was 79.4% and 84.7% in the 140 mg/day and 100 mg/day groups, respectively, and dose reductions due to AEs were experienced by 61.8% and 72.0%, respectively. Common grade 3/4 AEs included fatigue, diarrhea, and palmar-plantar erythrodysesthesia syndrome. Conclusions Cabozantinib showed evidence of clinical activity in patients with recurrent GBM naive to antiangiogenic therapy, although the predefined statistical target for success was not met. At the starting doses assessed, AEs were frequently managed with dose reductions. Clinical Trials Registration Number NCT00704288 (https://www.clinicaltrials.gov/ct2/show/NCT00704288) PMID

Three-Mile Island Program

International Nuclear Information System (INIS)

Malinauskas, A.P.

1983-01-01

Activities associated with the Three-Mile Island (TMI) Program were of two types. One involved providing technical review and guidance for specific recovery efforts at TMI, whereas the second was concerned more directly with providing technical assistance to recovery operations through detailed analyses and experimental activities. The work was divided into four elements: Task I - coordination of and participation in the operation of the Technical Advisory Group (TAG) for the cleanup of aqueous streams at TMI; Task II - participation in the Technical Assistance and Advisory Group (TAAG) on TMI operations; Task III - chemical development and other technical support to TMI recovery operations; and Task IV - development of inorganic sorbents for the decontamination of aqueous streams. At the program review that was conducted approximately mid-fiscal year, it was decided to curtail the Task IV activities in favor of studies of more-urgent problems. Technical progress for each of the tasks of this program is presented

Progress report No. 2 on the Scientific Investigation Program for the Nevada Yucca Mountain Site, October 1, 1989--March 31, 1990

International Nuclear Information System (INIS)

1990-01-01

In accordance with the requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982 (Pub. L. No. 97-425), as amended, the US Department of Energy (DOE) has prepared this report on the progress of scientific investigation activities at Yucca Mountain in southern Nevada for October 1, 1989, through March 31, 1990. This report is the second of a series of reports that are issued at intervals of approximately six months during the period of scientific investigation. The progress report presents short summaries of the status of scientific investigation activities and cites technical reports and research products that provide more detailed information on the activities. The report provides highlights of work started during the reporting period, work in progress, and work completed and documented during the reporting period. In addition, the report is the vehicle for discussing major changes, if any, to the DOE's scientific investigation program. The progress report conveys information in a convenient summary form to be used for informational purposes only. It is not intended to be the mechanism for controlling and documenting technical or policy positions regarding changes in schedules or the technical program. Such changes are controlled through rigorous DOE change-control procedures. The progress report only describes such approval changes. 49 refs., 3 tabs

A program in medium-energy nuclear physics

International Nuclear Information System (INIS)

Berman, B.L.; Dhuga, K.S.

1992-01-01

This report reviews progress on our nuclear-physics program for the last year, and includes as well copies of our publications and other reports for that time period. The structure of this report follows that of our 1991 Renewal Proposal and Progress Report: Sec. II outlines our research activities aimed at future experiments at CEBAF, NIKHEF, and Bates; Sec. III gives results of our recent research activities at NIKHEF, LAMPF, and elsewhere; Sec. IV provides an update of our laboratory activities at GWU, including the acquisition of our new Nuclear Detector Laboratory at our new Virginia Campus; and Sec. V is a list of our publications, proposals, and other reports. copies of those on medium-energy nuclear physics are reproduced in the Appendix

Clinical Investigation Program Annual Progress Report

Science.gov (United States)

1989-10-01

Meeting, Washington DC, September 1989 Parsons MK: Acute Shift of Right Ventricular Distensibility After Balloon Pulmonary Vavuloplasty. American Heart...selected range of motion using both concentric and eccentric muscular contractions. PROGRESS: No. of Subjects Enrolled - To Date: 8 Reporting Period: 8 1

Multifunctional e-spun colloidal nanofiber structures from various dispersed blends of PVA/ODA-MMT with PVP/ODA-MMT, poly(VP-alt-MA and AgNPs incorporated polymer complexes as electro-active platforms

Directory of Open Access Journals (Sweden)

U. Bunyatova

2016-07-01

Full Text Available This work presented a new approach to fabricate polymer nanocomposites films with nanofiber structures from solution blends of poly(vinyl alcohol + octadecyl amine-montmorillonite (ODA-MMT (matrix with poly(N-vinylpyrrolidone + ODA-MMT (partner-1, poly(N-vinylpyrrolidone-alt-maleic anhydride ((poly(VP-alt-MA + (ODA-MMT (partner-2 and their silver (Ag-carrying polymer complexes by electrospinning. Chemical and physical structures, surface morphologies, thermal behaviors, electrical conductivity and thermal resistance parameters of nanofiber structures were investigated. Poly(VP-alt-MA was used both as a crosslinker and a donor of the hydrophilic groups such as ‒COOH and ‒NH–C=O amide from pyrrolidone ring. Reactive poly(VP-alt-MA, in situ generated Ag nanoparticles (AgNPs and original partner polymer had an significant effect on the morphology and diameter distribution of nanofibers. High and excellent conductive behaviors were observed for the homopolymer and copolymer of VP based fiber structures, respectively. Upon successive chemical cross-linking of the nanofiber structures by reactive partner copolymer, the conductivity of nanofiber films as electro-active platforms dramatically increased to 3.90·10–2 S·cm–1 at room temperature. Comparative analysis results also indicated that electrical properties strongly depended on the loaded reactive organoclay and in situ generated AgNPs.

Quarterly Program Progress Report April 1, 2002-June 30, 2002

Energy Technology Data Exchange (ETDEWEB)

Palafox, Neal A., MD, MPH

2002-07-31

DOE B188 DOE/PHRI Special Medical Care Program in the Republic of the Marshall Islands (RMI)Quarterly Program Progress Report The DOE/PHRI Special Medical Care Program continues to provide, on a year round basis, a broad spectrum of medical care to the DOE patient population. During the fourth quarter of Year 4, the following medical services were provided: (1) Annual medical examinations for the DOE patient population (see Exhibit 1 for details). (2) Medications for the DOE patient population. (3) Preventive and primary medical care to the DOE patient population in the RMI as time and resources permit. (4) Additional manpower for the outpatient clinics at Ebeye and Majuro Hospitals (see Exhibit 2 for details). (5) Ancillary services such as labs, radiology and pharmacy in coordination with Kwajalein Hospital, Majuro Hospital and the 177 Health Care Program (177 HCP). (6) Referrals to Ebeye Hospital, Majuro Hospital and Kwajalein Hospital as necessary. (7) Referrals to Straub Clinic and Hospital in Honolulu as necessary (for details see Exhibit 1). (8) Monitored and adjusted monthly annual examination schedules based on equipment failure at Kwajalein. In addition to the above, the program was also involved in the following activities during this quarter: (1) Organized and conducted continuing medical education (CME) talks for the program's RMI staff and other RMI healthcare workers. (2) Held meetings with RMI government officials and Local Atoll government officials. (3) Input past medical records into the Electronic Medical Record (EMR) system. (4) Made adjustments to and created more templates for the EMR system. (5) Coordinated with the Public Health Departments on Majuro and Ebeye. (6) Met with PEACESAT to discuss possible collaboration on high speed Internet access. (7) Looked for opportunities to expand the program's telehealth capabilities. (8) Participated in the DOE-RMI Meeting in Honolulu. (9) Finalized the agreement with the RMI Ministry of

Progress in Ultrafast Intense Laser Science II

CERN Document Server

Yamanouchi, Kaoru; Agostini, Pierre; Ferrante, Gaetano

2007-01-01

This book series addresses a newly emerging interdisciplinary research field, Ultrafast Intense Laser Science, spanning atomic and molecular physics, molecular science, and optical science. Its progress is being stimulated by the recent development of ultrafast laser technologies. Highlights of this second volume include Coulomb explosion and fragmentation of molecules, control of chemical dynamics, high-order harmonic generation, propagation and filamentation, and laser-plasma interaction. All chapters are authored by foremost experts in their fields and the texts are written at a level accessible to newcomers and graduate students, each chapter beginning with an introductory overview.

Letter report for the superconducting magnet development program (Number 4). Progress report, June 1, 1975--September 1, 1975

International Nuclear Information System (INIS)

1976-01-01

The program objectives are outlined. Brief discussions of research progress are given for the following: systems design, coil design, conductor selection and test, radiation effects, coil protection, structural analysis and material tests, cryogenics and refrigeration, coil fabrication, and coil test and evaluation

Progress toward fusion with light ions

International Nuclear Information System (INIS)

1980-01-01

New results in target design, beam generation and transport, and pulse power technology have led to a program shift stressing light ion-driven inertial confinement fusion. According to present estimates, a gain ten fusion pellet will require at least one megajoule and approx. 100 TW power input. Progress in ion sources has resulted in beam power density of approx. 1 TW/cm 2 , a factor of ten increase over the last year, and cylindrical implosion experiments have been performed. Other experiments have demonstrated the ability to transport ion and electron beams with high efficiency and have confirmed numerical predictions on the properties of beam transport channels converging at a target. These developments together with improvements in pulse power technology allow us to project that the 72 beam, 100 TW Particle Beam Fusion Accelerator, PBFA-II will attain target output energy equal to stored energy in the accelerator

Fuel-cycle programs. Quarterly progress report, January-March 1981

International Nuclear Information System (INIS)

Steindler, M.J.; Vogler, S.; Vandegrift, G.F.

1982-03-01

A program continues for the development of an interim waste form that can be transported from facilities where waste is generated to terminal waste processing. Measurements of rates of leaching from simulated nuclear waste forms ar continuing. The data suggest that leaching from SRL glasses is inhibited by the formation of a Si/Ca/Fe/Al-rich surface layer. Impact tests of solid alternative waste forms (glass and ceramic) are being performed to assess source terms of airborne release (from particle size distributions) and to assess the increases in source terms of leach rates (from increases in surface area). Logging techniques are being developed to measure the relative amount of residual oil in a depleted oil reservoir. A simple technique for the elution of pore fluid (groundwater) from igneous rocks is described, using a special coreholder, as is the elution of brine (in the same apparatus) from a core of Precambrian granite. Testing and development of equipment for the destructive analysis of full-length irradiated fuel rods from the LWBR is in progress

Beneficial uses program. Progress report, period ending 31 December 1975

International Nuclear Information System (INIS)

1976-02-01

Progress is reported on studies designed to develop the necessary technologies for cost-beneficial uses of existing and future surplus radioactive materials. The purpose of the Waste Resources Utilization Program is to develop a technology to utilize cesium-137, a nuclear power plant by-product, to modify sewage sludge for safe application as a fertilizer or as an animal feed supplement. A major portion of the effort this quarter was directed toward establishment of thermoradiation treatment levels for elimination of pathogenic organisms in sludge. Three groups of pathogenic microorganisms are being studied: viruses, bacteria, and parasites. Other areas of study included physical-chemical properties of thermoradiation treated sewage sludge such as ''settling'' and ''filterability'' and pilot plant design for a plant to thermoradiate up to 75 kiloliters of sludge per day. In the Separation Technology and Source Development Program previous work has demonstrated the feasibility of applying the Sandia Solidification Process to the recovery of radiocesium from high-level liquid wastes. The influence of various parameters on 137 Cs source intensities was explored. A multiple ceramic 137 Cs source package was found to be essentially the same from a radiation process viewpoint as a single 137 Cs source. The tolerable impurity levels in the ceramic sources, in terms of perturbation of the gamma flux, are relatively high (a few percent)

High energy physics studies progress report. Part I. Experimental program

International Nuclear Information System (INIS)

1977-01-01

The experimental program of research, including Assembly of an experiment at Fermilab E-351 to measure decay lifetimes, with tagged emulsion, of charmed particles produced by high energy neutrinos will continue. A data-taking run will take place in the coming fiscal year. Participation in the neutrino experiment E-310, Fermilab-Harvard-Pennsylvania-Rutgers-Wisconsin, will also continue. Data analysis from several experiments performed in the recent past at the ZGS ANL is in progress and will be pursued. These experiments are, E-397, E-420 and E-428 performed with the Charged and Neutral Spectrometer, and E-347 with the Σ/sub β/ Spectrometer. Plans are in the making to collaborate with a polarized proton experiment at the ZGS. New approaches to ''third generation'' neutrino experiments at Fermilab are being discussed by the whole high energy group. Ideas of pursuing experiments at the AGS-BNL with the Σ/sub β/ Spectrometer are explored. The theoretical research program covers topics of current interest in particle theory which will be investigated in the coming year; namely, the role of instantons in quantum chromodynamics, Higgs Lagrangian involving scalar fields, phenomenology of neutrino physics and in particular the nature of trimuon production, higher order symmetries like SU(3) x U(1) SU(5) and SU(6), dynamics of high energy diffractive scattering, classical solutions to the gauge field theories

Energy Extension Service Pilot Program: evaluation report after two years. Volume I. Evaluation summary

Energy Technology Data Exchange (ETDEWEB)

None

1980-04-01

The EES pilot program was initiated in August 1977, when 10 states were selected on a competitive basis for participation. The pilot states (Alabama, Connecticut, Michigan, New Mexico, Pennsylvania, Tennessee, Texas, Washington, Wisconsin, and Wyoming) devoted the first 6 months to start-up activities. This document is a follow-up report to the three volume Evaluation Summary of the first year of the pilot EES program published in September 1979. The purpose of this report is to provide an overview of the impacts and costs of the two years of the pilot program, and to check the consistency of findings over the two year period. The analysis addresses the following: (1) were the impact findings of Year I and Year II consistent, or did Year I and Year II attitudes and behavior vary. If variation existed, could it be attributed to program changes as the EES progressed from a start-up phase (Year I) to more normal service delivery (Year II); and (2) did costs of service delivery change (again reflecting start-up and normal service delivery costs). Did cost changes affect conclusions about the relative cost effectiveness of delivering services to different target audiences.

A program in medium energy nuclear physics. Progress report and continuation proposal October 1, 1995

International Nuclear Information System (INIS)

Berman, B.L.; Dhuga, K.S.

1995-01-01

This progress report and continuation proposal summarizes our achievements for the period from July 1, 1994 to September 30, 1995 and requests continued funding for our program in experimental medium-energy nuclear physics. The focus of our program remains the understanding of the short-range part of the strong interaction in the nuclear medium. In the past year we have focused our attention ever more sharply on experiments with real tagged photons, and we have successfully defended two new experimental proposals: Photofission of Actinide and Preactinide Nuclei at SAL and Photoproduction of the ρ Meson from the Proton with Linearly Polarized Photons at CEBAF. (We are co-spokespersons on two previously approved Hall-B experiments at CEBAF, Photoreactions on 3 He and Photoabsorption and Photofission of Nuclei.) As part of the team that is instrumenting the Photon Tagger for Hall B; we report excellent progress on the focal-plane detector array that is being built at our Nuclear Detector Laboratory, as well as progress on our plans for instrumentation of a tagged polarized-photon beam using coherent bremsstrahlung. Also, we shall soon receive a large computer system (from the SSC) which will form the basis for our new Data Analysis Center, which, like the Nuclear Detector Laboratory, will be operated under the auspices of The George Washington University Center for Nuclear Studies. Finally, during the past year we have published six more papers on the results of our measurements of pion scattering at LAMPF and of electron scattering at NIKHEF and Bates, and we can report that nearly all of the remaining papers documenting this long series of measurements are in the pipeline

Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release

Directory of Open Access Journals (Sweden)

2009-05-01

Full Text Available Poly(carboxylic acid-polysaccharide compositions have been found suitable for obtaining drug formulations with controlled release, most formulations being therapeutically efficacious, stable, and non-irritant. The influence of the characteristics of the aqueous solutions from which the polymer matrix is prepared (i.e. the total concentration of polymer in solutions and the mixing ratio between the partners, hydroxypropyl cellulose, HPC and maleic acid-alternating-styrene copolymer, MAc-alt-S on the kinetics of some drugs release in acidic environment (pH = 2 has been followed by ‘in vitro’ dissolution tests. It has been established that the kinetics of procaine hydrochloride release from HPC/MAc-alt-S matrix depends on its composition; the diffusion exponent, n is close to 0.5 for matrices where one of the components is in large excess and n~0.02 for middle composition range. The lower value of diffusion exponent for middle composition range could be caused by the so called ‘burst effect’, therefore the kinetic evaluation is difficult.

Rigid Polyurethane Foam (RPF) Technology for Countermines (Sea) Program Phase II

Energy Technology Data Exchange (ETDEWEB)

WOODFIN,RONALD L.; FAUCETT,DAVID L.; HANCE,BRADLEY G.; LATHAM,AMY E.; SCHMIDT,C.O.

1999-10-01

This Phase II report documents the results of one subtask initiated under the joint Department of Energy (DOE)/Department of Defense (DoD) Memorandum of Understanding (MOU) for Countermine Warfare. The development of Rigid Polyurethane Foams for neutralization of mines and barriers in amphibious assault was the objective of the tasking. This phase of the program concentrated on formation of RPF in water, explosive mine simulations, and development of foam and fabric pontoons. Field experimentation was done primarily at the Energetic Materials Research and Testing Center (EMRTC) of the New Mexico Institute of Mining and Technology, Socorro, NM between February 1996 and September 1998.

Overview of the TCV tokamak program: scientific progress and facility upgrades

Science.gov (United States)

Coda, S.; Ahn, J.; Albanese, R.; Alberti, S.; Alessi, E.; Allan, S.; Anand, H.; Anastassiou, G.; Andrèbe, Y.; Angioni, C.; Ariola, M.; Bernert, M.; Beurskens, M.; Bin, W.; Blanchard, P.; Blanken, T. C.; Boedo, J. A.; Bolzonella, T.; Bouquey, F.; Braunmüller, F. H.; Bufferand, H.; Buratti, P.; Calabró, G.; Camenen, Y.; Carnevale, D.; Carpanese, F.; Causa, F.; Cesario, R.; Chapman, I. T.; Chellai, O.; Choi, D.; Cianfarani, C.; Ciraolo, G.; Citrin, J.; Costea, S.; Crisanti, F.; Cruz, N.; Czarnecka, A.; Decker, J.; De Masi, G.; De Tommasi, G.; Douai, D.; Dunne, M.; Duval, B. P.; Eich, T.; Elmore, S.; Esposito, B.; Faitsch, M.; Fasoli, A.; Fedorczak, N.; Felici, F.; Février, O.; Ficker, O.; Fietz, S.; Fontana, M.; Frassinetti, L.; Furno, I.; Galeani, S.; Gallo, A.; Galperti, C.; Garavaglia, S.; Garrido, I.; Geiger, B.; Giovannozzi, E.; Gobbin, M.; Goodman, T. P.; Gorini, G.; Gospodarczyk, M.; Granucci, G.; Graves, J. P.; Guirlet, R.; Hakola, A.; Ham, C.; Harrison, J.; Hawke, J.; Hennequin, P.; Hnat, B.; Hogeweij, D.; Hogge, J.-Ph.; Honoré, C.; Hopf, C.; Horáček, J.; Huang, Z.; Igochine, V.; Innocente, P.; Ionita Schrittwieser, C.; Isliker, H.; Jacquier, R.; Jardin, A.; Kamleitner, J.; Karpushov, A.; Keeling, D. L.; Kirneva, N.; Kong, M.; Koubiti, M.; Kovacic, J.; Krämer-Flecken, A.; Krawczyk, N.; Kudlacek, O.; Labit, B.; Lazzaro, E.; Le, H. B.; Lipschultz, B.; Llobet, X.; Lomanowski, B.; Loschiavo, V. P.; Lunt, T.; Maget, P.; Maljaars, E.; Malygin, A.; Maraschek, M.; Marini, C.; Martin, P.; Martin, Y.; Mastrostefano, S.; Maurizio, R.; Mavridis, M.; Mazon, D.; McAdams, R.; McDermott, R.; Merle, A.; Meyer, H.; Militello, F.; Miron, I. G.; Molina Cabrera, P. A.; Moret, J.-M.; Moro, A.; Moulton, D.; Naulin, V.; Nespoli, F.; Nielsen, A. H.; Nocente, M.; Nouailletas, R.; Nowak, S.; Odstrčil, T.; Papp, G.; Papřok, R.; Pau, A.; Pautasso, G.; Pericoli Ridolfini, V.; Piovesan, P.; Piron, C.; Pisokas, T.; Porte, L.; Preynas, M.; Ramogida, G.; Rapson, C.; Rasmussen, J. Juul; Reich, M.; Reimerdes, H.; Reux, C.; Ricci, P.; Rittich, D.; Riva, F.; Robinson, T.; Saarelma, S.; Saint-Laurent, F.; Sauter, O.; Scannell, R.; Schlatter, Ch.; Schneider, B.; Schneider, P.; Schrittwieser, R.; Sciortino, F.; Sertoli, M.; Sheikh, U.; Sieglin, B.; Silva, M.; Sinha, J.; Sozzi, C.; Spolaore, M.; Stange, T.; Stoltzfus-Dueck, T.; Tamain, P.; Teplukhina, A.; Testa, D.; Theiler, C.; Thornton, A.; Tophøj, L.; Tran, M. Q.; Tsironis, C.; Tsui, C.; Uccello, A.; Vartanian, S.; Verdoolaege, G.; Verhaegh, K.; Vermare, L.; Vianello, N.; Vijvers, W. A. J.; Vlahos, L.; Vu, N. M. T.; Walkden, N.; Wauters, T.; Weisen, H.; Wischmeier, M.; Zestanakis, P.; Zuin, M.; the EUROfusion MST1 Team

2017-10-01

The TCV tokamak is augmenting its unique historical capabilities (strong shaping, strong electron heating) with ion heating, additional electron heating compatible with high densities, and variable divertor geometry, in a multifaceted upgrade program designed to broaden its operational range without sacrificing its fundamental flexibility. The TCV program is rooted in a three-pronged approach aimed at ITER support, explorations towards DEMO, and fundamental research. A 1 MW, tangential neutral beam injector (NBI) was recently installed and promptly extended the TCV parameter range, with record ion temperatures and toroidal rotation velocities and measurable neutral-beam current drive. ITER-relevant scenario development has received particular attention, with strategies aimed at maximizing performance through optimized discharge trajectories to avoid MHD instabilities, such as peeling-ballooning and neoclassical tearing modes. Experiments on exhaust physics have focused particularly on detachment, a necessary step to a DEMO reactor, in a comprehensive set of conventional and advanced divertor concepts. The specific theoretical prediction of an enhanced radiation region between the two X-points in the low-field-side snowflake-minus configuration was experimentally confirmed. Fundamental investigations of the power decay length in the scrape-off layer (SOL) are progressing rapidly, again in widely varying configurations and in both D and He plasmas; in particular, the double decay length in L-mode limited plasmas was found to be replaced by a single length at high SOL resistivity. Experiments on disruption mitigation by massive gas injection and electron-cyclotron resonance heating (ECRH) have begun in earnest, in parallel with studies of runaway electron generation and control, in both stable and disruptive conditions; a quiescent runaway beam carrying the entire electrical current appears to develop in some cases. Developments in plasma control have benefited from

The US Liquid Metal Reactor Development Program

International Nuclear Information System (INIS)

Till, C.E.; Arnold, W.H.; Griffith, J.D.

1988-01-01

The US Liquid Metal Reactor Development Program has been restructured to take advantage of the opportunity today to carry out R and D on truly advanced reactor technology. The program gives particular emphasis to improvements to reactor safety. The new directions are based on the technology of the Integral Fast Reactor (IFR). Much of the basis for superior safety performance using IFR technology has been experimentally verified and aggressive programs continue in EBR-II and TREAT. Progress has been made in demonstrating both the metallic fuel and the new electrochemical processes of the IFR. The FFTF facility is converting to metallic fuel; however, FFTF also maintains a considerable US program in oxide fuels. In addition, generic programs are continuing in steam generator testing, materials development, and, with international cooperation, aqueous reprocessing. Design studies are carried out in conjunction with the IFR technology development program. In summary, the US maintains an active development program in Liquid Metal Reactor technology, and new directions in reactor safety are central to the program

Ageing management program of wires for Atucha II Nuclear Power Plant

International Nuclear Information System (INIS)

Zorrilla, J.; Antonaccio, E.; Luraschi, C.; Simionato, E.; Nieto, H.

2012-01-01

Electrical cables constitute one of the most important components of NPP in terms o maintenance, safety and availability of the plant. Due to their large extension (thousands of kilometers) it is impossible to fully replace them and aging management becomes essential for long term operation of NPP. Since Atucha II is under construction there was a good opportunity to establish and implement a holistic cable aging management program from the beginning according to the state of the art in this field. The scope of this program involves safety related cables, including EQ cables and non EQ cables as well. Due to the diversity of the installed cables is impossible to address an aging management program of every single specimen. However it is possible to establish 'cables families' of similar aging behavior based on insulation and jacket material, manufacture, etc Several aging management strategies were set for the different 'cables families'. These strategies include cables deposit in plant, elaboration of procedures of visual and tactile inspection, NDE techniques, etc Currently the aging management program is being implemented covering topic such as: Cable screening and grouping. Review of EQ documentation and conventional qualification information referring to the installed cables. Establishment of base line of condition monitoring techniques. Calibration and set up of test parameters for NDE techniques. Aging mechanism characterization and determination of. Design construction and installation of cable deposit in plant (author)

AFCT/TFCT/ISFS Program. Technical progress report for the period October 1, 1977--December 31, 1977

Energy Technology Data Exchange (ETDEWEB)

Hill, O.F. (comp.)

1978-02-01

This is the eighth in a series of quarterly progress reports on studies performed for the Alternate Fuel Cycle Technologies/Thorium Fuel Cycle Technologies/International Spent Fuel Receipt and Storage (AFCT/TFCT/ISFS) Program, formerly the LWR Fuel Recycle Program. This program is designed to provide information needed by industry to close the back end of the power reactor fuel cycle. During the past quarter, studies were conducted in the following tasks: Survey of Current Technology of Fuel Handling Techniques; Investigation of Air Cleaning Processes for Removing Tributyl Phosphate (TBP) from Off-Gas Streams; Study of Iodine Chemistry in Process Solutions; Electropolishing to Decontaminate Metallic Waste from Alternate and Thorium Converter Fuel Cycles; and U.S. Scale Transport, Dispersion and Removal Mode Comparison Safety Criticality Experiments. (11 figs., 7 tables)

Waste Isolation Safety Assessment Program. Technical progress report for FY-1978

Energy Technology Data Exchange (ETDEWEB)

Brandstetter, A.; Harwell, M.A.; Howes, B.W.; Benson, G.L.; Bradley, D.J.; Raymond, J.R.; Serne, R.J.; Schilling, A.H.

1979-07-01

Associated with commercial nuclear power production in the United States is the generation of potentially hazardous radioactive wastes. The Department of Energy (DOE) is seeking to develop nuclear waste isolation systems in geologic formations that will preclude contact with the biosphere of waste radionuclides in concentrations which are sufficient to cause deleterious impact on humans or their environments. Comprehensive analyses of specific isolation systems are needed to assess the expectations of meeting that objective. The Waste Isolation Safety Assessment Program (WISAP) has been established at the Pacific Northwest Laboratory (operated by Battelle Memorial Institute) for developing the capability of making those analyses. Progress on the following tasks is reported: release scenario analysis, waste form release rate analysis, release consequence analysis, sorption-desorption analysis, and societal acceptance analysis. (DC)

ANADP II Program Committee Closing Remarks 2013

OpenAIRE

Program Committee

2014-01-01

Aligning National Approaches to Digital Preservation: An Action Assembly Biblioteca de Catalunya (National Library of Catalonia) November 18-20, 2013, Barcelona, Spain summary The Aligning National Approaches to Digital Preservation (ANADP) II Action Assembly will align digital preservation efforts internationally between communities—including national libraries, academic libraries, public libraries, research centers, archives, corporations, and funding agencies. ANADP II will be a highly par...

Recent Progress and Development of Crystal Structure Analysis of Enzymes and Other Proteins

Science.gov (United States)

Tanokura, Masaru; Nagata, Koji; Miyazono, Ken-Ichi; Miyakawa, Takuya; Okai, Masahiko

Structural biology has made tremendous progress in this decade. Here we briefly introduce the Target Proteins Research Program, a national project promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The program aims to reveal the structure and function of proteins that are of great importance in both academic research and industrial application. We also summarize the results of structure-function analyses of (i) transcriptional regulatory proteins useful for the breading of drought and heat stress tolerant crops, (ii) useful enzymes for the production of chiral compounds, and (iii) useful enzymes for the degradation of environmental pollution substances. These results can be utilized in various areas of industries, to enhance food production, to improve the efficiency of pharmaceutical compound production, and to promote the bioremediation of contaminated soil and water.

Feedback on the Inaugural Meeting of the Cost 347 Accelerated Loading Test (ALT) Action in Europe: June 27th to 29th 2001

CSIR Research Space (South Africa)

De Beer, Morris

2001-11-01

Full Text Available . The author presented two topics, i.e. Accelerated Pavement Testing (APT) in South Africa, and Stress-In-Motion (SIM). This COST 347 action started in October 2001, and needs to deliver recommendations on ALT April 2004. There are 6 Working Groups, chaired...

The U.S. nuclear waste management program - technical progress at Yucca Mountain

Energy Technology Data Exchange (ETDEWEB)

Barrett, L.H. [U.S. Department of Energy (United States)

2001-07-01

This paper discusses the current status of a national program being developed by the U.S. Department of Energy for the management of spent nuclear fuel and high-level radioactive waste produced by civilian nuclear power generation and defense-related activities. In 1987 the U.S. Congress directed the Department to characterize the Yucca Mountain site in Nevada and determine its suitability for development of a geologic repository. This paper will focus on the technical progress that has been made after more than 15 years of scientific and engineering investigations at Yucca Mountain, and the remaining work that is being done to support a decision on whether to recommend the site for development of a geologic repository. (author)

Near-term electric-vehicle program. Phase II. Mid-term review summary report

Energy Technology Data Exchange (ETDEWEB)

1978-07-27

The general objective of the Near-Term Electric Vehicle Program is to confirm that, in fact, the complete spectrum of requirements placed on the automobile (e.g., safety, producibility, utility, etc.) can still be satisfied if electric power train concepts are incorporated in lieu of contemporary power train concepts, and that the resultant set of vehicle characteristics are mutually compatible, technologically achievable, and economically achievable. The focus of the approach to meeting this general objective involves the design, development, and fabrication of complete electric vehicles incorporating, where necessary, extensive technological advancements. A mid-term summary is presented of Phase II which is a continuation of the preliminary design study conducted in Phase I of the program. Information is included on vehicle performance and performance simulation models; battery subsystems; control equipment; power systems; vehicle design and components for suspension, steering, and braking; scale model testing; structural analysis; and vehicle dynamics analysis. (LCL)

Full-scale Mark II CRT program: dynamic response evaluation test of pressure transducers

International Nuclear Information System (INIS)

Kukita, Yutaka; Namatame, Ken; Takeshita, Isao; Shiba, Masayoshi

1982-12-01

A dynamic response evaluation test of pressure transducers was conducted in support of the JAERI Full-Scale Mark II CRT (Containment Response Test) Program. The test results indicated that certain of the cavity-type transducers used in the early blowdown test had undesirable response characteristics. The transducer mounting scheme was modified to avoid trapping of air bubbles in the pressure transmission tubing attached to the transducers. The dynamic response of the modified transducers was acceptable within the frequency range of 200 Hz. (author)

Overviews of EMRAS I and II

International Nuclear Information System (INIS)

Kawaguchi, Isao

2011-01-01

Recently there has been attracting growing interest in impacts of irradiation to wildlife organisms. In IAEA, biota dosimetry working group (BWG) was established in Environmental Modeling for Radiation Safety (EMRAS) program, which aimed to intercompare biota dose assessment models to validate their assumptions and estimations. After EMRAS program finished, new program which is referred as EMRAS II was set on January 2009. In EMRAS II, there are three themes, and 9 working groups were established. One of three themes is related to environmental protection, and three working groups (Biota modeling, wildlife transfer coefficient handbook, biota dose effects modeling) were constituted in it. In this report, activities of EMRAS I BWG and EMRAS II theme II are summarized. (author)

MHC Class II epitope predictive algorithms

DEFF Research Database (Denmark)

Nielsen, Morten; Lund, Ole; Buus, S

2010-01-01

Major histocompatibility complex class II (MHC-II) molecules sample peptides from the extracellular space, allowing the immune system to detect the presence of foreign microbes from this compartment. To be able to predict the immune response to given pathogens, a number of methods have been...... developed to predict peptide-MHC binding. However, few methods other than the pioneering TEPITOPE/ProPred method have been developed for MHC-II. Despite recent progress in method development, the predictive performance for MHC-II remains significantly lower than what can be obtained for MHC-I. One reason...

Silicon germanium (SiGe) radioisotope thermoelectric generator (RTG) program for space missions. Nineteenth technical progress report, December 1980-January 1981

International Nuclear Information System (INIS)

1981-01-01

Work accomplished during the reporting period on the DOE Silicon Germanium RTG Program, Contract DE-AC01-79ET-32043 is described. This program consists of the following three tasks: multi-hundred watt RTG for the Galileo probe mission; reestablishment of silicon germanium unicouple capability; and general purpose heat source RTG for the international solar polar and Galileo orbiter missions. Details of program progress for each task, including a milestone schedule and a discussion of current problem areas (if any) are presented

Synthesis of electro-optically active polymer composite of poly[2,2'-bis(3,4-ethylenedioxythiophene-alt-fluorene]/hydroxypropyl cellulose showing liquid crystal structure

Directory of Open Access Journals (Sweden)

N. Eguchi

2017-10-01

Full Text Available Electrochemical preparation of a composite consisting of poly[2,2′-bis(3,4-ethylenedioxythiophene-alt-fluorene] and hydroxypropyl cellulose (PEFE/HPC was carried out. We conducted electrochemical polymerization of poly[2,2′-bis(3,4-ethylenedioxythiophene-alt-fluorene] (EFE as a monomer in a lyotropic liquid crystal of HPC. We used an organic solvent instead of water for lyotropic liquid crystal medium to expand the possibility of the range of monomers, although water is usually employed as a solvent for HPC for showing liquid crystallinity. Here, we employed N,N-dimethylformamide (DMF as a solvent for HPC. Electrochemical polymerization in the polymer liquid crystal was carried out to obtain a polymer film with liquid crystal order. The polymer film thus prepared exhibited optical activity. Fourier transfer infrared (FT-IR absorption spectroscopy reveals that the film is a composite consisting of HPC and polymer. The composite PEFE/HPC thus prepared in HPC/DMF system showed electrochromism.

'Culture and memory of the Sto. Antonio do Morro Grande/MG Quilombola community' program - case study: environmental licensing progress for the Rio de Janeiro-Belo Horizonte Gas Pipeline (GASBEL II)

Energy Technology Data Exchange (ETDEWEB)

Ismerio, Marcia [Pallos Environmental Consulting, Rio de Janeiro, RJ (United States); Bartolini, Marcia [PETROBRAS, Rio de Janeiro, RJ (Brazil)

2009-07-01

The 'Culture and Memory of the Sto. Antonio do Morro Grande Quilombola Community' Program was included in the environmental licensing process of the Rio de Janeiro-Minas Gerais gas pipeline ('GASBEL II'), as requested by the Palmares Cultural Foundation (Fundacao Cultural Palmares), which stipulates the elaboration and implementation of this program as a condition for obtaining the installation license. To develop the program and submit it to this institution, we used methodological procedures in the form of an anthropological social research, such as: interviews with the community's older or most active residents, and a preliminary recognition of the territory and the local culture; all in order to learn more about the community's history and current needs and to identify the remaining 'quilombolas' still living in the community. Analyzing the information raised the need for guided actions designed to rescue the community's cultural memory as an ethnic group and to contribute to its process of affirmation as a Traditional Rural 'Quilombola' Community. This led to the creation of the proposed 'Culture and Memory of the Sto. Antonio do Morro Grande Quilombola Community' Program, currently being developed for the Quilombola Community located in Ressaquinha, in the State of Minas Gerais. (author)

The EBR-II materials-surveillance program. 5: Results of SURV-5

International Nuclear Information System (INIS)

Ruther, W.E.; Staffon, J.D.; Carlson, B.G.; Allen, T.R.

1998-01-01

In March of 1965, a set of surveillance (SURV) samples was placed in the EBR-II reactor to determine the effect of irradiation, thermal aging, and sodium corrosion on reactor materials. Eight subassemblies were placed into row 12 positions of EBR-II to determine the effect of irradiation at 370 C. Two subassemblies were placed into the primary sodium basket to determine the effect of thermal aging at 370 C. One half of all samples were exposed to primary system sodium while one half were sealed in capsules with a helium atmosphere. Fifteen different structural materials were tested in the SURV program. In this work, the properties of these materials irradiated at 370 C to a total fluence of 3.2 x 10 22 n/cm 2 were determined. These materials are the fifth set of irradiated subassemblies to be examined as part of the SURV program (SURV-5). The properties analyzed were weight, density, microstructure, hardness, tensile and yield strength, and fracture resistance. Of all the alloys examined in SURV-5, only Berylco-25 showed any significant weight loss. Stainless steel (both 304 and 347) had the largest density decrease, although the density decrease from irradiation for all alloys was less than 0.4 percent. The microstructure of both Berylco-25 and the aluminum-bronze alloy was altered significantly. Iron- and nickel-base alloys showed little change in microstructure. Austenitic steels (304 and 347) harden with irradiation. The hardness of Inconel X750 did not change significantly with irradiation. The ultimate tensile strength of Inconel X750, 304 stainless steel, 420 stainless steel and welded 304 changed little due to a fluence increase from 2.2 x 10 22 n/cm 2 (the maximum fluence of the SURV-4 samples) to 3.2 x 10 22 n/cm 2

Program plan for the DOE Office of Fusion Energy First Wall/Blanket/Shield Engineering Technology Program. Volume II. Detailed technical plan. Revision 2

International Nuclear Information System (INIS)

1982-08-01

The four sections which comprise Part II describe in detail the technical basis for each of the four Program Elements (PE's) of the FWBS Engineering Technology Program (ETP). Each PE is planned to be executed in a number of phases. The purpose of the DTP's is to delineate detailed near-term research, development, and testing required to establish a FWBS engineering data base. Optimum testing strategies and construction of test facilities where needed are identified. The DTP's are based on guidelines given by Argonne National Laboratory which included the basic programmatic goals and the requirements for the types of tests and test conditions

EBRPOCO - a program to calculate detailed contributions of power reactivity components of EBR-II

International Nuclear Information System (INIS)

Meneghetti, D.; Kucera, D.A.

1981-01-01

The EBRPOCO program has been developed to facilitate the calculations of the power coefficients of reactivity of EBR-II loadings. The program enables contributions of various components of the power coefficient to be delineated axially for every subassembly. The program computes the reactivity contributions of the power coefficients resulting from: density reduction of sodium coolant due to temperature; displacement of sodium coolant by thermal expansions of cladding, structural rods, subassembly cans, and lower and upper axial reflectors; density reductions of these steel components due to temperature; displacement of bond-sodium (if present) in gaps by differential thermal expansions of fuel and cladding; density reduction of bond-sodium (if present) in gaps due to temperature; free axial expansion of fuel if unrestricted by cladding or restricted axial expansion of fuel determined by axial expansion of cladding. Isotopic spatial contributions to the Doppler component my also be obtained. (orig.) [de

The LLNL [Lawrence Livermore National Laboratory] ICF [Inertial Confinement Fusion] Program: Progress toward ignition in the Laboratory

International Nuclear Information System (INIS)

Storm, E.; Batha, S.H.; Bernat, T.P.; Bibeau, C.; Cable, M.D.; Caird, J.A.; Campbell, E.M.; Campbell, J.H.; Coleman, L.W.; Cook, R.C.; Correll, D.L.; Darrow, C.B.; Davis, J.I.; Drake, R.P.; Ehrlich, R.B.; Ellis, R.J.; Glendinning, S.G.; Haan, S.W.; Haendler, B.L.; Hatcher, C.W.; Hatchett, S.P.; Hermes, G.L.; Hunt, J.P.; Kania, D.R.; Kauffman, R.L.; Kilkenny, J.D.; Kornblum, H.N.; Kruer, W.L.; Kyrazis, D.T.; Lane, S.M.; Laumann, C.W.; Lerche, R.A.; Letts, S.A.; Lindl, J.D.; Lowdermilk, W.H.; Mauger, G.J.; Montgomery, D.S.; Munro, D.H.; Murray, J.R.; Phillion, D.W.; Powell, H.T.; Remington, B.R.; Ress, D.B.; Speck, D.R.; Suter, L.J.; Tietbohl, G.L.; Thiessen, A.R.; Trebes, J.E.; Trenholme, J.B.; Turner, R.E.; Upadhye, R.S.; Wallace, R.J.; Wiedwald, J.D.; Woodworth, J.G.; Young, P.M.; Ze, F.

1990-01-01

The Inertial Confinement Fusion (ICF) Program at the Lawrence Livermore National Laboratory (LLNL) has made substantial progress in target physics, target diagnostics, and laser science and technology. In each area, progress required the development of experimental techniques and computational modeling. The objectives of the target physics experiments in the Nova laser facility are to address and understand critical physics issues that determine the conditions required to achieve ignition and gain in an ICF capsule. The LLNL experimental program primarily addresses indirect-drive implosions, in which the capsule is driven by x rays produced by the interaction of the laser light with a high-Z plasma. Experiments address both the physics of generating the radiation environment in a laser-driven hohlraum and the physics associated with imploding ICF capsules to ignition and high-gain conditions in the absence of alpha deposition. Recent experiments and modeling have established much of the physics necessary to validate the basic concept of ignition and ICF target gain in the laboratory. The rapid progress made in the past several years, and in particular, recent results showing higher radiation drive temperatures and implosion velocities than previously obtained and assumed for high-gain target designs, has led LLNL to propose an upgrade of the Nova laser to 1.5 to 2 MJ (at 0.35 μm) to demonstrate ignition and energy gains of 10 to 20 -- the Nova Upgrade

DOE program guide for universities and other research groups. Part I. DOE Research and Development Programs; Part II. DOE Procurement and Assistance Policies/Procedures

Energy Technology Data Exchange (ETDEWEB)

1980-03-01

This guide addresses the DOE responsibility for fostering advanced research and development of all energy resources, both current and potential. It is intended to provide, in a single publication, all the fundamental information needed by an institution to develop a potential working relationship with DOE. Part I describes DOE research and development programs and facilities, and identifies areas of additional research needs and potential areas for new research opportunities. It also summarizes budget data and identifies the DOE program information contacts for each program. Part II provides researchers and research administrators with an introduction to the DOE administrative policies and procedures for submission and evaluation of proposals and the administration of resulting grants, cooperative agreements, and research contracts. (RWR)

A Multiple-star Combined Solution Program - Application to the Population II Binary μ Cas

Science.gov (United States)

Gudehus, D. H.

2001-05-01

A multiple-star combined-solution computer program which can simultaneously fit astrometric, speckle, and spectroscopic data, and solve for the orbital parameters, parallax, proper motion, and masses has been written and is now publicly available. Some features of the program are the ability to scale the weights at run time, hold selected parameters constant, handle up to five spectroscopic subcomponents for the primary and the secondary each, account for the light travel time across the system, account for apsidal motion, plot the results, and write the residuals in position to a standard file for further analysis. The spectroscopic subcomponent data can be represented by reflex velocities and/or by independent measurements. A companion editing program which can manage the data files is included in the package. The program has been applied to the Population II binary μ Cas to derive improved masses and an estimate of the primordial helium abundance. The source code, executables, sample data files, and documentation for OpenVMS and Unix, including Linux, are available at http://www.chara.gsu.edu/\\rlap\\ \\ gudehus/binary.html.

Research on radionuclide migration under subsurface geochemical conditions. JAERI/AECL Phase II Collaborative Program Year 1 (joint research)

International Nuclear Information System (INIS)

1998-11-01

A radionuclide migration experiment program for fractured rocks was performed under the JAERI/AECL Phase-II Collaborative Program on research and development in radioactive waste management. The program started in the fiscal year 1993, as a five-year program consists of Quarried block radionuclide migration program, Speciation of long-lived radionuclides in groundwater, Isotopic hydrogeology and Groundwater flow model development. During the first year of the program (Program Year 1: March 18, 1994 - September 30, 1994), a plan was developed to take out granite blocks containing part of natural water-bearing fracture from the wall of the experimental gallery at the depth of 240 m, and literature reviews were done in the area of the speciation of long-lived radionuclides in groundwater, isotopic hydrogeology and the groundwater flow model development to proceed further work for the Program Year 2. (author)

CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes.

Science.gov (United States)

Kadri, Nadir; Korpos, Eva; Gupta, Shashank; Briet, Claire; Löfbom, Linda; Yagita, Hideo; Lehuen, Agnes; Boitard, Christian; Holmberg, Dan; Sorokin, Lydia; Cardell, Susanna L

2012-04-01

Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have the ability to regulate immunity, including autoimmunity. We previously demonstrated that CD1d-restricted type II NKT cells, which carry diverse TCRs, prevented T1D in the NOD mouse model for the human disease. In this study, we show that CD4(+) 24αβ type II NKT cells, but not CD4/CD8 double-negative NKT cells, were sufficient to downregulate diabetogenic CD4(+) BDC2.5 NOD T cells in adoptive transfer experiments. CD4(+) 24αβ NKT cells exhibited a memory phenotype including high ICOS expression, increased cytokine production, and limited display of NK cell markers, compared with double-negative 24αβ NKT cells. Blocking of ICOS or the programmed death-1/programmed death ligand 1 pathway was shown to abolish the regulation that occurred in the pancreas draining lymph nodes. To our knowledge, these results provide for the first time cellular and molecular information on how type II CD1d-restricted NKT cells regulate T1D.

PARÁMETROS BIOQUÍMICOS ENZIMÁTICOS (ALT, AST, ALP, Γ-GT, LDH EN NIÑOS CON LEUCEMIA LINFOBLÁSTICA AGUDA ANTES DEL TRATAMIENTO ANTINEOPLÁSICO

Directory of Open Access Journals (Sweden)

Jeél Moya S

2015-12-01

Full Text Available Objective: To determine the enzymatic biochemical parameters (glutamic pyruvic transaminase (ALT, glutamic oxaloacetic transaminase (AST, alkaline phosphatase (ALP, gamma glutamyltransferase (γ-GT, and lactate dehydrogenase (LDH in children with acute lymphoblastic leukemia (ALL before cancer treatment. Material and Methods: A prospective experimental, observational, cross-sectional study was conducted in 30 children between 2 and 15 years old, from several Neoplastic Centers in Lima. Blood collection was performed in BD red cap Vacutainer tubes, processed in the semi-automated analyzer BIOTEC® EMP-168, with Wiener Lab Group enzyme reagents under the modified method Szaaz and UV-Optimized by IFCC, SSCC and SFBC. Finally, coding and tabulation was performed. Results: 60% were boys and 46.7% are between the ages of 2-6 years. Serum levels of AST were increased by 33.3% in boys and 50% in girls. Serum ALT values were increased in 33.3% of boys and 41.7% of girls; only 25% of girls showed increased levels of γ-GT values; ALP was increased in 44.4% of boys and 66.7% of girls. Moreover LDH levels were increased in 55.6% of boys and 41.7% of girls. Conclusions: The enzymatic tests LDH, AST, ALT and ALP are increased in children with ALL compared to normal values due to tumor lysis syndrome characterized by electrolyte abnormalities, and as a result of the massive destruction of tumor cells and rapid release of large amounts of intracellular elements.

Views of the electric utility industry on the direction and progress of the Department of Energy's Nuclear Waste Program

International Nuclear Information System (INIS)

Mills, L.E.

1986-01-01

The NWPA does provide guidance for a reasonable waste management program and one must work to implement it in an efficient and effective manner. It is well recognized that the lack of stability and predictability has been the bane of many nuclear reactor projects. The electric utilities are not satisfied with the progress of the nuclear waste program even though much has been achieved. DOE must continue in its struggle to seek a better balance between the technical, political and institutional aspects of the program to provide reasonable assurance that it will fulfill its contractual obligation with utilities

A single-arm phase II trial of pazopanib in patients with advanced non-small cell lung cancer with non-squamous histology with disease progression on bevacizumab containing therapy.

Science.gov (United States)

Weiss, Jared M; Villaruz, Liza C; Socinski, Mark A; Ivanova, Anastasia; Grilley-Olson, Juneko; Dhruva, Nirav; Stinchcombe, Thomas E

2014-11-01

Platinum-based chemotherapy with bevacizumab is a standard therapy for patients with stage IIIB/IV non-small cell lung cancer (NSCLC) with non-squamous (NS) histology. Mechanisms of resistance to bevacizumab include increased VEGF signaling or activation of VEGF receptors. Pazopanib is a multi-targeted VEGF receptor tyrosine kinase with single agent activity in NSCLC. Stage IIIB/IV patients with adequate organ function, who progressed on a bevacizumab containing therapy were eligible if it had been ≤8 weeks since the last bevacizumab treatment. The primary end-point was disease control rate (DCR), defined as partial or complete response, or stable disease for ≥12 weeks. Patients were assessed radiographically every 2 cycles (6 weeks). A Simon 2-stage design was used, and if in the first stage ≤4 of 17 patients experienced disease control the trial was to have been stopped for futility. An unplanned analysis was performed after 15 patients were evaluable secondary to slow accrual. Between December 2010 and November 2013, 15 patients were treated on trial. The median age was 61 years (range 39-74), and all patients had stage IV disease. Of the 15 patients, 4 discontinued therapy prior to cycle 2 evaluation due to adverse events (n=3) and medical illness (n=1), 5 patients had progressive disease, 4 patients had stable disease for <12 weeks, and 2 patients had stable disease for ≥12 weeks. No responses were observed. The DCR observed was 13% (2/15), and the trial did not meet the criteria to proceed to the second stage. Episodes of grade 3 treatment related toxicities observed included: increased ALT (n=2), increased AST (n=1), anorexia (n=3), fatigue (n=3), hypertension (n=1), infection (n=1), mucositis (n=2), nausea (n=3), pericardial effusion (n=1), and vomiting (n=1). Pazopanib has limited activity in NSCLC-NS in patients who have experienced disease progression on bevacizumab. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

High-energy physics at Tufts University. Progress report, August 1, 1982-July 31, 1983

International Nuclear Information System (INIS)

1983-01-01

Progress on the following topics is described: neutrino-deuterium interactions; anti pN interactions; K/sub s/ 0 /K/sub s/ 0 π - p interactions at 300 GeV/c; phi phi final states in 400 GeV/c pp; Fermilab Tevatron MPS proposals; nu D-physics proposed using HBC with internal calorimeter; Talloires neutrino workshop; photoproduction of charmed particles; streamer chamber study of anti K* 0 (890); Soudan-II nucleon decay program; CCD-detector study; optical resolution study; measuring hardware systems and data links; hadronic production of chi mesons; high-p/sub t/ inelastic hadronic reactions; and theoretical investigations

77 FR 23228 - Notice of Submission for OMB Review; Small Business Innovation Research (SBIR) Program-Phase II...

Science.gov (United States)

2012-04-18

... business concerns to submit a Phase II application for the Small Business Innovation Research (SBIR) Program (CFDA 84.133). This is in response to Public Law 106-554, the ``Small Business Reauthorization Act... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Small Business Innovation Research...

Security programs for Category I or II nuclear material or certain nuclear facilities. Regulatory guide G-274

International Nuclear Information System (INIS)

2003-03-01

The purpose of this regulatory guide is to help applicants for a Canadian Nuclear Safety Commission (CNSC) licence in respect of Category I or II nuclear material - other than a licence to transport - , or a nuclear facility consisting of a nuclear reactor that may exceed 10 MW thermal power during normal operation, prepare and submit the security information to be included with the application, pursuant to the Nuclear Safety and Control Act (NSCA). Category I and II nuclear material are defined in Appendix B to this guide. This guide describes: the security information that should typically be included with the application for any licence referred to above; how the security information may be organized and presented in a separate document (hereinafter 'the security program description'), in order to assist CNSC review and processing of the application; and, the administrative procedures to be followed when preparing, submitting or revising the security program description. (author)

Progress report of a research program in computational physics

International Nuclear Information System (INIS)

Guralnik, G.S.

1990-01-01

Task D's research is focused on the understanding of elementary particle physics through the techniques of quantum field theory. We make intensive use of computers to aid our research. During the last year we have made significant progress in understanding the weak interactions through the use of Monte Carlo methods as applied to the equations of quenched lattice QCD. We have launched a program to understand full (not quenched) lattice QCD on relatively large lattices using massively parallel computers. Because of our awareness that Monte Carlo methods might not be able to give a good solution to field theories with the computer power likely to be available to us for the forseeable future we have launched an entirely different numerical approach to study these problems. This ''Source Galerkin'' method is based on an algebraic approach to the field theoretic equations of motion and is (somewhat) related to variational and finite element techniques applied to a source rather than a coordinate space. The results for relatively simple problems are sensationally good. In particular, fermions can be treated in a way which allows them to retain their status as independent dynamical entities in the theory. 8 refs

Los Alamos progress report for RIPL-II

International Nuclear Information System (INIS)

Young, P.G.; Chadwick, M.B.; Moeller, P.

2000-01-01

Since the last RIPL-II CRP meeting, we have developed a code that prepares inputs from the RIPL-I optical model parameter data base for the SCAT2 and ECIS96 computer codes. We have also made limited corrections to the optical model parameter file, and have made minor extensions to the format for optical potentials. We have implemented mass information from the RIPL-I mass library into the ground-state mass/spin/parity file (Tape13) used in GNASH and other codes. Additionally, we have developed software for using the generalized superfluid level density model on SUN computers at LANL, ultimately for use of the RIPL-I level density information in the GNASH code. (author)

PHEBUS program: first results on PWR fuel behaviour in LOCA conditions

International Nuclear Information System (INIS)

Del Negro, R.; Reocreux, M.; Pelce, J.; Legrand, B.; Berna, P.

1982-09-01

In the first PHEBUS test with pressurized rods some rods burst and clad temperature reached 1100 0 C in the 25 rods bundle. There is now a lot of valuable experimental results and their analysis is in progress. The phase II on fuel behaviour in case of a large LOCA will start at the beginning of 83. The onset of the SFD program is foreseen to take place on the first months of 85

Extension of the RPV irradiation surveillance program of NPP GKN II by T0 approach

International Nuclear Information System (INIS)

Barthelmes, J.; Keim, E.; Hein, H.; Koenig, G.

2015-01-01

The nuclear power plant (NPP) Neckarwestheim II (GKN II) started operation in 1989 and was designed for 40 years of operation. During the plant life time the reactor pressure vessel (RPV) integrity is a main aspect for nuclear safety since the RPV is exposed to neutron irradiation affecting the mechanical material properties, in particular toughness. In this context the ductile to brittle transition reference temperature of the RPV materials can be determined either indirectly according to the RT(NDT) concept by means of comparative examinations of irradiated and unirradiated notched-bar impact specimens or directly according to the Master Curve concept by means of examination of irradiated fracture mechanic specimens and determination of an alternative reference temperature RT(T0). With the implementation and evaluation of the first irradiation surveillance program consisting of three sets, one unirradiated reference set (set 1) and two irradiated sets (set 2 and 3), the RPV safety could be proven for the assessment fluence (AF) of 8*10 18 cm -2 (E > 1 MeV) using the RT(NDT) concept. Against the background of a possible long term operation and the state-of-the-art of science and technology in 1998 the NPP GKN II initiated a supplemental irradiation surveillance program with two irradiation sets (set 4 and 5) containing fracture mechanic specimens for complementary proof of safety according to the Master Curve concept. The results of the first irradiated set 4 are presented and assessed by means of the reference temperatures according to the Master Curve concept and compared to the results of the irradiation sets 1 to 3 of the conventional irradiation surveillance program. As an important outcome the existing RPV integrity assessment could be ensured by the Master Curve results. The applied approach adapts to the state-of-the-art of science and technology and is best practice to ensure the safe operation of RPV supplementary. (authors)

TRUPACT-II container maintenance program plan

International Nuclear Information System (INIS)

1990-01-01

This document details the maintenance/repair and replacement of components, as well as the documentation required and the procedures to be followed to maintain the integrity of the TRUPACT-II container

Politiken, Alt om Ikast Brande (web), Lemvig Folkeblad (Web), Politiken (web), Dabladet Ringkjøbing Skjern (web)

DEFF Research Database (Denmark)

Lauritsen, Jens

2014-01-01

Politiken 01.01.2014 14:16 Danskerne skød nytåret ind med et brag, men for enkeltes vedkommende gik det galt, da nytårskrudtet blev tændt. Skadestuerne har behandlet 73 personer for fyrværkeriskader mellem klokken 18 i aftes og klokken 06 i morges. Det viser en optælling, som Politiken har...... foretaget på baggrund af tal fra Ulykkes Analyse Gruppen på Odense Universitetshospital. Artiklen er også bragt i: Alt om Ikast Brande (web), Lemvig Folkeblad (web), Politiken (web), Dagbladet Ringkjøbing Skjern (web)....

Sample Exchange Evaluation (SEE) Report - Phase II

Energy Technology Data Exchange (ETDEWEB)

Winters, W.I.

1994-09-28

This report describes the results from Phase II of the Sample Exchange Evaluation (SEE) Program, a joint effort to compare analytical laboratory performance on samples from the Hanford Site`s high-level waste tanks. In Phase II, the program has been expanded to include inorganic constituents in addition to radionuclides. Results from Phase II that exceeded 20% relative percent difference criteria are identified.

Sample Exchange Evaluation (SEE) Report - Phase II

International Nuclear Information System (INIS)

Winters, W.I.

1994-01-01

This report describes the results from Phase II of the Sample Exchange Evaluation (SEE) Program, a joint effort to compare analytical laboratory performance on samples from the Hanford Site's high-level waste tanks. In Phase II, the program has been expanded to include inorganic constituents in addition to radionuclides. Results from Phase II that exceeded 20% relative percent difference criteria are identified

LipidII : Just Another Brick in the Wall?

NARCIS (Netherlands)

Scheffers, Dirk-Jan; Tol, Menno B

2015-01-01

Nearly all bacteria contain a peptidoglycan cell wall. The peptidoglycan precursor molecule is LipidII, containing the basic peptidoglycan building block attached to a lipid. Although the suitability of LipidII as an antibacterial target has long been recognized, progress on elucidating the role(s)

Incontri di Fisica delle Alte Energie Italian Meeting on High Energy Physics Napoli

CERN Document Server

Carlino, Gianpaolo; Merola, Leonardo; Paolucci, Pierluigi; Ricciardi, Giulia; IFAE 2007

2008-01-01

This book collects the Proceedings of the Workshop "Incontri di Fisica delle Alte Energie (IFAE) 2007, Napoli, 11-13 April 2007". This is the sixth edition of a series of meetings on fundamental research in particle physics and was attended by about 160 researchers. Presentations, both theoretical and experimental, addressed the status of Physics of the Standard Model and beyond, Flavour phyisc, Neutrino and Astroparticle physics, new technology in high energy physics. Special emphasis was given to the expectations of the forthcoming Large Hadron Collider, due in operation at the end of 2007. The venue of plenary sessions interleaved with parallel ones allowed for a rich exchange of ideas, presented in these Proceedings, that form a coherent picture of the findings and of the open questions in this extremely challenging cultural field. The venue of plenary sessions interleaved with parallel ones allowed for a rich exchange of ideas, presented in these Proceedings, that form a coherent picture of the findings ...

Progress assessed with the Mayo-Portland Adaptability Inventory in 604 participants in 4 types of post-inpatient rehabilitation brain injury programs.

Science.gov (United States)

Eicher, Vicki; Murphy, Mary Pat; Murphy, Thomas F; Malec, James F

2012-01-01

To compare progress in 4 types of post-inpatient rehabilitation brain injury programs. Quasiexperimental observational cohort study. Community and residential. Individuals (N=604) with acquired brain injury. Four program types within the Pennsylvania Association of Rehabilitation Facilities were compared: intensive outpatient and community-based rehabilitation (IRC; n=235), intensive residential rehabilitation (IRR; n=78), long-term residential supported living (SLR; n=246), and long-term community-based supported living (SLC; n=45). With the use of a commercial web-based data management system developed with federal grant support, progress was examined on 2 consecutive assessments. Mayo-Portland Adaptability Inventory (MPAI-4). Program types differed in participant age (F=10.69, PMPAI-4 score (F=6.89, PMPAI-4 score and chronicity were significantly associated with the second MPAI-4 rating. On average, SLR participants were 9.1 years postinjury compared with 5.1 years for IRR, 6.0 years for IRC, and 6.8 years for SLC programs. IRR participants were more severely disabled per MPAI-4 total score on admission than the other groups. Controlling for these variables, program types varied significantly on second MPAI-4 total score (F=5.14, P=.002). Both the IRR and IRC programs resulted in significant functional improvement across assessments. In contrast, both the SLR and SLC programs demonstrated relatively stable MPAI-4 scores. Results are consistent with stated goals of the programs; that is, intensive programs resulted in functional improvements, whereas supported living programs produced stable functioning. Further studies using data from this large, multiprovider measurement collaboration will potentially provide the foundation for developing outcome expectations for various types of postacute brain injury programs. Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Central Corneal Thickness Measurement by Ultrasound versus Orbscan II

Directory of Open Access Journals (Sweden)

Amir Faramarzi

2008-12-01

Full Text Available

PURPOSE: To compare Orbscan II and ultrasonic pachymetry for measurement of central corneal thickness (CCT in eyes scheduled for keratorefractive surgery. METHODS: CCT was measured using Orbscan II (Bausch & Lomb, USA and then by ultrasonic pachymetry (Tomey SP-3000, Tomey Ltd, Japan in 100 eyes of 100 patients with no history of ocular surgery scheduled for excimer laser refractive surgery. RESULTS: Mean CCT was 544.7±35.5 (range 453-637 µm by ultrasonic pachymetry versus 546.9±41.6 (range 435-648 µm measured by Orbscan II applying an acoustic factor of 0.92 (P=0.14. The standard deviation of measurements was greater with Orbscan pachymetry but the difference was not statistically significant. CONCLUSION: CCT measurements by Orbscan II (applying an acoustic factor and by ultrasonic pachymetry are not significantly different; however, when CCT readings by Orbscan II are in the lower range, it is advisable to recheck the measurements using ultrasonic pachymetry.