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Sample records for alprostadil

  1. Alprostadil Urogenital

    Science.gov (United States)

    ... relaxing the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur.Alprostadil does ... provided in the package and injected into the penis and as a urethral suppository (pellet to be ...

  2. Does alprostadil cream hit the spot?

    Science.gov (United States)

    2015-02-01

    Alprostadil, a prostaglandin, has been marketed for many years as a urethral stick and an intracavernous injection for the treatment of erectile dysfunction.(1) It is now available in the form of a cream (Vitaros-Takeda). Adverts for the product declare: "Sex with no pills, pellets or needles. Spot on." In this article, we consider the evidence for alprostadil cream, and its place in the management of erectile dysfunction. PMID:25678352

  3. Effectiveness of combined alprostadil and pancreatic kininogenas in treating gerontal diabetic peripheral neuropathy

    Institute of Scientific and Technical Information of China (English)

    张玉

    2013-01-01

    Objective To observe the clinical effectiveness of alprostadil combined with pancreatic kininogenas in the treatment of gerontal diabetic peripheral neuropathy.Methods Totally 90 gerontal patients with diabetic peripheral neuropathy were randomly divided into three

  4. Intracavernosal alprostadil is effective for the treatment of erectile dysfunction in diabetic men

    NARCIS (Netherlands)

    Heaton, JPW; Lording, D; Liu, SN; Litonjua, AD; Guangwei, L; Kim, SC; Kim, JJ; Zhi-Zhou, S; Israr, D; Niazi, D; Rajatanavin, R; Suyono, S; Benard, F; Casey, R; Brock, G; Belanger, A

    2001-01-01

    The efficacy and safety of intracavernosal alprostadil was evaluated for the treatment of erectile dysfunction in men with type I or type II diabetes mellitus. This was an open-label, flexible dose-escalating study involving 336 men (77% of whom were Asian/Oriental) enrolled by 15 centres in Austral

  5. How effective are alprostadil and hydrocortisone on reperfusion injury in kidney after distant organ ischemia?

    Directory of Open Access Journals (Sweden)

    Ali Ebrahimi

    2013-01-01

    Full Text Available Background: After reestablishment of blood flow to ischemic limb recirculation of free radicals may cause ischemia-reperfusion injury in many organs. This study designed to investigate effects of hydrocortisone and alprostadil distant injury to kidneys by both measuring biochemical markers of oxidative stress and histopathologic examination in an experimental rat model of hind limb ischemia-reperfusion. Materials and Methods: This study conducted in Isfahan University of Medical Sciences during 2011-2012. Ischemia was established by infra renal aortic clamping for 60 min in 32 male Wistar rats. Animals were divided into those receiving alprostadil (group ischemia-reperfusion plus alprostadil (IR/A, n = 8, those receiving hydrocortisone (group ischemia-reperfusion plus hydrocortisone (IR/H, n = 8, control group (group ischemia-reperfusion (IR, n = 8, and sham group (n = 8. After 120 min of reperfusion both kidneys were removed. Levels of superoxide dismutase (SOD, malondialdehyde (MDA, and glutathione (GSH as indirect markers of oxidative injury was measured. Finally all data in different groups were compared using the analysis of variance (ANOVA test by Statistical Package for Social Sciences (SPSS version 16. Results: Administration of alprostadil or hydrocortisone does not improve the biochemical parameters of oxidative injury including MDA and SOD. However, statistically significant difference was seen in GSH level among sham and IR groups. Mean (΁ standard deviation (SD concentration of GSH in IR, IR/A, IR/H, and sham groups were 1028.77 (72.65, 924.82 (70.66, 1000.28 (108.77, and 846.69 (163.52, respectively (P = 0.015. Histopathological study of specimens did not show any significant changes between groups. Conclusion: Alprostadil and hydrocortisone do not improve the kidney GSH, SOD, and MDA level and kidney releases its GSH reserve during ischemia-reperfusion event, and another point is that, 3 h of ischemia-reperfusion does not develop

  6. Renoprotective effect of alprostadil in combination with statins in patients with mild to moderate renal failure undergoing coronary angiography

    Institute of Scientific and Technical Information of China (English)

    LIU Wei-jing; ZHANG Bu-chun; GUO Rong; WEI Yi-dong; LI Wei-ming; XU Ya-wei

    2013-01-01

    Background The role of alprostadil and statins in contrast-induced acute kidney injury (CI-AKI) is controversial.The purpose of this study was to explore the efficacy of combined therapy with alprostadil and statins in protecting renal function and preventing contrast-induced nephropathy (CIN) in patients undergoing coronary angiography.Methods A total of 156 consecutive patients with mild to moderate renal failure who underwent coronary angiography were enrolled in our study,and randomly categorized into two groups.In the statins group,80 patients were treated with statins before and after coronary angiography.in the alprostadil plus statins group,76 patients were treated with statins and alprostadil before and after coronary angiography.Serum creatinine (SCr),serum cystatin (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) were detected after administration of contrast media,and adverse events were evaluated within six months.Results In both groups,the SCr,CysC and NGAL significantly increased after coronary angiography and peaked at 48,24 and 6 hours,respectively.SCr,CysC and NGAL were significantly lower in the alprostadil plus statins group than in the statins group (P<0.05).The incidence of CIN in the alprostadil plus statins group was slightly lower than in the statins group.The incidence of adverse events within six months in the alprostadil plus statins group was significantly lower than in the statins group (P=0.034).Conclusions Intravenous alprostadil in combination with oral statins is superior to statins alone for protecting renal function in patients with mild to moderate renal dysfunction who undergo coronary angiography,and can reduce the incidence of adverse events seen within six months.

  7. Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats

    Science.gov (United States)

    Erer, Dilek; Özer, Abdullah; Demirtaş, Hüseyin; Gönül, İpek Işık; Kara, Halil; Arpacı, Hande; Çomu, Faruk Metin; Oktar, Gürsel Levent; Arslan, Mustafa; Küçük, Ayşegül

    2016-01-01

    Objectives To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. Materials and methods Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period. Effects of agents on renal, lung, and skeletal muscle (gastrocnemius) tissue specimens were examined. Results Renal medullary congestion, cytoplasmic swelling, and mean tubular dilatation scores were significantly lower in the alprostadil-treated group than those found in the I/R-only group (P<0.0001, P=0.015, and P<0.01, respectively). Polymorphonuclear leukocyte infiltration, pulmonary partial destruction, consolidation, alveolar edema, and hemorrhage scores were significantly lower in alprostadil- and iloprost-treated groups (P=0.017 and P=0.001; P<0.01 and P<0.0001). Polymorphonuclear leukocyte infiltration scores in skeletal muscle tissue were significantly lower in the iloprost-treated group than the scores found in the nontreated I/R group (P<0.0001). Conclusion Alprostadil and iloprost significantly reduce lung tissue I/R injury. Alprostadil has more prominent protective effects against renal I/R injury, while iloprost is superior in terms of protecting the skeletal muscle tissue against I/R injury. PMID:27601882

  8. Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review

    Science.gov (United States)

    Anaissie, James; Hellstrom, Wayne JG

    2016-01-01

    Erectile dysfunction (ED) is a common and debilitating disorder seen in over 50% of men older than 70 years. Oral phosphodiesterase type 5 (PDE5) inhibitors are the mainstay of treatment for ED, but cannot be used by a significant subset of patients due to systemic side effects and drug–drug interactions. Second-line therapy may include intracavernosal therapies, but are associated with poor compliance due to their invasive nature. Alprostadil has a mechanism of action different from that of PDE5 inhibitors. Clinical trials have shown topical alprostadil cream to be effective, increasing the erectile function (EF) score of the International Index of EF by up to 13 points from baseline. It has also proven to be safe and well tolerated, with mild-to-moderate and transient treatment-related adverse events that are generally localized to the application site. Topical alprostadil cream is a safe and effective second-line therapy for ED, indicated for those who cannot tolerate, or are not satisfied with, oral PDE5 inhibitor therapy. PMID:27536559

  9. Effect of alprostadil on hemorheology, immune function, MDA, SOD and ROS in patients with diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    Li-Li Xia; Yu-Bin Tang; Kan Shao

    2016-01-01

    Objective: To investigate the effect of alprostadil on hemorheology, oxidative stress and immune function in patients with diabetic nephropathy. Methods:A total of 90 cases of diabetic nephropathy patients were divided into control group (45 cases) and observation group (45 cases). The control group was treated by conventional therapy, and the observation group was received extra alprostadil. The levels of hemorheology, oxidative stress and immune function indexes were measured and compared. Results:The levels of blood glucose, blood lipid and UAER had a significant improvement in both groups, and the level of UAER in the observation group decreased more significantly than that in the control group after treatment;the levels of hemorheology indexes (high, middle and low shear of blood viscosity, plasma viscosity, deformation index and erythrocyte aggregation index) had a significant improvement after treatment, and the levels of low shear of blood viscosity and erythrocyte aggregation index in the observation group decreased more significantly than that in the control group after treatment. The levels of oxidative stress indexes (MDA, ROS and SOD) had a significant improvement in both groups, and the levels of MDA, ROS and SOD decreased more significantly after treatment. The levels of CD4+, CD4+/CD8+ in the observation group increased significantly after treatment, while the level of CD8+ had no significant improvement. The levels of CD4+, CD8+,CD4+/CD8+in the control group had no significant differences, while the levels of CD4+, CD4+/CD8+in the observation group were significantly higher than that in the control group. Conclusions:Alprostadil treatment can obviously improve renal function, hemorheology, oxidative stress and immune function in patients with diabetic nephropathy.

  10. Evaluation of transurethral application of alprostadil for erectile dysfunction in Indonesians

    Institute of Scientific and Technical Information of China (English)

    WimpieI.Pangkahila

    2000-01-01

    Aim: To evaluate the efficacy and safety of transurethral application of alprostadil (MUSE.) for the treatment of erectile dysfunction in Indonesians. Methods: Twenty erectile dysfunction patients aged between 32 - 74 years old were recruited in this study. The inclusion criteria were as follows: 1 ) adult males 18 years or older with a subjective complaint or erectile dysfunction, 2) to provide written informed consent, 3) to agree not to use other forms of treatment for erectile dysfunction, 4) fulfill the screening laboratory values. Part 1, eligible patients were titrated in the clinic starting with a dose of 250 μg and proceed in a stepwise manner to 500μg and 1000μg on separate clinic visits until they identified a dose that produced a satisfactory response. The interval between each in-clinic titration was 2-3 days. Each in-clinic titration dose was evaluated at 15 min intervals over a one hour period for erection assessment, blood pressure and pulse. Part 2, patients used MUSE at home for three months at the dose identified during the inclinic titration. Monthly interim visits were required for patient follow-up and drug distribution. At the end of the study, patients had another laboratory (except testosterone, only assayed in screening procedure) and physical examination. Results: The etiology of erectile dysfunction was psychological in 5 patients and organic in 15 patients. The 65% of the patients achieved the erection scale of 4 or 5 either in the clinic or at home, 10% achieved the scale of 4 at home, but not in the clinic, and 25 % only achieved the scale of 2 or 3 with the highest dose of 1000μg either in the clinic or at home. No significant differences were found in biochemical examination before and after the study. The 60 % of the patients who achieved erection scale 4 or 5 continued to use MUSE until the end of the study, while 40 % of them complained of pain at the time of MUSE application, during erection and/or during intercourse. They

  11. Alprostadil liposome microsphere preparation stabilizes vascular plaques and inhibits intra-plaque inflammation

    Institute of Scientific and Technical Information of China (English)

    CHEN Li; CHENG Wen-li; WANG Yong; KE Yuan-nan; FAN Shu-ying; PAN Lin; GUO Yan-ru; LI Hong; GUO Jian

    2012-01-01

    Background Vulnerable plaques play an important role in the onset of sudden cardiac events and strokes.How to stabilize vulnerable plaques is still a challenge to medical science.Alprostadil is a biologically active substance with strong activity on vessel.Our study assessed the stabilizing effects of an alprostadil liposome microsphere preparation (ALMP) on vulnerable plaques in the brachiocephalic artery of apolipoprotein E (Apo E) knockout mice.Methods Seventy-two male Apo E-knockout mice were fed a high-fat diet beginning at eight weeks of age.At week 17,they were divided randomly into groups for treatment with a high dose (3.6 μg · kg-1 · d-1) or low dose (1.8 μg · kg-1 · d-1) of an ALMP,or 0.2 ml/d normal saline (control group).The drug was administered using a micro-capsule pump.Twenty weeks after drug administration,pathological changes in the vulnerable plaques within the brachiocephalic artery were assessed,and levels of anti-mouse monocyte/macrophage monoclonal antibody (MOMA-2) and superoxide anions in the plaques were detected using immunofluorescence.The soluble intercellular adhesion molecule-1 (ICAM-1) expression was measured by ELISA,and the expression of matrix metalloproteinase-9 (MMP-9) and CD40 mRNA was measured using RT-PCR.Thrombospindin-1 (TSP-1) expression was detected using Western blotting.Results Compared with the control group,ALMP treatment significantly reduced the plaque area in the brachiocephalic artery (P <0.01),significantly lowered the contents of the lipid core (P <0.01),significantly reduced the number of ruptured fibrous caps (P <0.05),and increased the thickness of the fibrous cap and significantly reduced the incidence of intra-plaque hemorrhage (P <0.05).ALMP treatment significantly reduced the expression of MOMA-2,superoxide anion,MMP-9,ICAM-1 and CD40 in the plaques (P <0.01),decreased plasma ICAM-1 expression (P <0.01),and increased the expression of TSP-1.Conclusions Treatment with ALMP can stabilize

  12. Research about the influence of alprostadil for the renal blood flow parameters and fibrosis indexes of patients with diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    Li Ling; Guo-Juan Lao; Li-Bo Chen; Diao-Zhu Lin

    2016-01-01

    Objective:To observe the curative effects of alprostadil on diabetes nephropathy and its influences on the renal blood flow parameters and fibrosis indexes of patients.Methods:Eighty cases of patients with diabetic nephropathy who were treated in our hospital from May 2013 to September 2014 were randomly selected as the research objects and were divided into the control group and the observation group. Each group had 40 cases. Patients of the control group were treated by routine therapy, while patients of the observation group were treated with alprostadil on the basis of routine therapy. The fasting blood glucose, renal function-related indexes, serum creatinine, blood urea nitrogen, urinary albumin excretion rate and fibrosis markers, matrix metalloproteinase-9 (MMP-9), hyaluronic acid (HA), laminin (LN),Ⅲ procollagen (PCⅢ) and typeⅣ collagen (ⅣC) of the two groups before and after treatments were respectively tested, and the peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI) and pulsatility index (PI) of renal artery segment were tested by color doppler ultrasound.Results:After 14 and 28 d of treatments, the blood urea nitrogen, urinary albumin excretion rate of the observation group were all significantly lower than those of the control group; the PSV and EDV were all significantly faster than those of the control group; RI and PI were all observably lower than those of the control group and the serum levels of MMP-9, HA, LN, PCⅢ, andⅣC were also prominently lower than those of the control group. Conclusions:Alprostadil can effectively slow the development of fibrosis and protect the renal function of patients with diabetic nephropathy by improving renal blood supply for them.

  13. Daily application of alprostadil topical cream (Vitaros) does not impact vaginal pH, flora, or histology in female cynomolgus monkeys.

    Science.gov (United States)

    Meier-Davis, Susan R; Debar, Salma; Siddoway, Jacob; Rabe, Mark

    2015-01-01

    Topical alprostadil cream (Vitaros) is approved in Canada and Europe for the treatment of erectile dysfunction. To determine the effects on the female urogenital tract with repeated administration of the entire dose (300 μg alprostadil containing 2.5% dodecyl-2-n,n-dimethylaminopropionate hydrochloride), the vaginal pH, flora, and histology were assessed as a model for 100% transference from male to the female during unprotected sexual intercourse. Female cynomolgus monkeys were administered the entire dose of Vitaros for 14 days with a 7-day recovery. Relative to vehicle and placebo cream, the vaginal pH and microflora were determined at baseline and weekly, thereafter. Vaginal biopsies were evaluated at the end of dosing and recovery. All animals were clinically normal for the study duration, and the vaginal pH was consistent between dose groups and the dosing period. Vaginal microflora and histopathology findings of mild inflammation were generally similar across treatment groups. In conclusion, repeated vaginal exposure to Vitaros did not alter the pH, microflora, or histology after 14 daily doses, supporting the safety of Vitaros transference to the female partner. PMID:25691520

  14. 肝肾联合移植后前列地尔的早期应用%Early application of alprostadil after combined liver and kidney transplantation

    Institute of Scientific and Technical Information of China (English)

    沈蓓莉; 苗书斋; 陈鹏; 彭玉华; 孙晓芬; 崔华; 郑珊

    2011-01-01

    BACKGROUND: Recently the liierature has been reported thai alprastadil can promote the recovery of graft function andreduce delayed recovery of renal function, acute rejection rate, and mortality.OBJECTIVE: To observe the effect of the early application of alprostadil after combined liver and kidney transplantation ongraft function recovery.METHODS: A total of 6 cases of combined liver and kidney transplantation patients were selected as experimental group whowere given alprostadil 30 μg/d during transplantation and 3 weeks after transplantation. Four cases of combined liver andkidney transplantation patients were selected as control group who were not given alprostadil during transplantation and aftertransplantation. Urine output, serum creatinine. Creatinine clearance, alamne amtnotransferase, aspartate ammotranslerase.Total bilirubin. Direct bilirubm, renal vascular resistance index, and biliary drainage volume of patients between two groupsafter transplantation were observed.RESULTS AND CONCLUSION: The urine output, creatinine clearance, biliary drainage volume of patients in experimentalgroup after transplantation was higher than that of control group (P < 0.05). Alanine aminotransf erase, aspartateaminotransferase, total bilirubin, direct bilirubin concentration, creatinine concentration, and renal vascular resistance indexwas lower than that of control group (P < 0.05). The results have confirmed that alprostadil has a positive significance in theearly recovery of transplanted liver and kidney function after combined liver and kidney transplantation.%背景:近来有文献报道,前列地尔可促进移植肾功能的恢复,降低肾功能恢复延迟与急性排斥反应发生率,减少死亡率.目的:观察肝肾联合移植后早期应用前列地尔对移植物功能恢复的影响.方法:选择6例肝肾联合移植患者作为实验组,移植过程中及移植后3周内给予前列地尔30 μg/d,同期选择4例移植过程中及移植后不给予

  15. 前列地尔对突发性耳聋听力恢复的效果分析%The effect analysis of Alprostadil on recruitment of hearing of patients with sudden deafness

    Institute of Scientific and Technical Information of China (English)

    梁晓东

    2003-01-01

    @@ BACKGROUND: Sudden deafness means sudden unknownneural deafness, which exact cause has not been found. And theroutine treatment adopts low molecular dextran and power mixtureand usually has a long course of treatment. Alprostadil useslipo-microball as carrier and does not easily lose activity and has theproper of distributing to injured blood vessehs, so brings into fullplay in dilating blood vessels and inhibiting gathering of bloodplatelet, which is used for curing sudden deafness.

  16. 前列地尔联合地塞米松治疗突发性聋疗效观察%Observation of alprostadil combined with dexamethasone in treatment of sudden deafness

    Institute of Scientific and Technical Information of China (English)

    胡成全

    2014-01-01

    To observe the curative effect of alprostadil combined with dexamethasone in the treatment of sudden deafness . Methods:Control group:normal saline 100ml+alprostadil 10 μg, QD ×14, intravenous infusion; treatment group: the addition of dexamethasone injection therapy based on the control group treatment .Results:The clinical effective rate was 80.39%, 58.33% in the control group , the difference was statistically significant by statistical analysis .Conclusion:Alprostadil combined with dexamethasone in treating sudden deafness should be worthy of promotion .%目的:观察前列地尔联合地塞米松治疗突聋的疗效。方法:对照组:生理盐水100ml+前列地尔10μg,1日1次,静脉滴注14天;治疗组:在对照组治疗的基础上加入地塞米松注射液治疗。结果:治疗组临床有效率为80.39%,对照组为58.33%,其差异经统计学分析有统计学意义。结论:前列地尔联合地塞米松治疗突发性聋疗效确切,值得推广。

  17. 前列地尔治疗糖尿病肾病的临床研究%Clinical research of Alprostadil in the treatment of diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    叶海燕; 杨昆; 周径; 张彦中

    2012-01-01

    目的 探讨联合应用前列地尔对糖尿病肾病患者的临床疗效.方法 将2010年1~12月我院收治的66例患者随机分为研究组和对照组各33例.两组患者均常规行降糖、饮食控制、蛋白摄入限量等基础性治疗,并给予卡托普利口服治疗,研究组患者在此基础上加用前列地尔.结果 研究组患者治疗后总有效率为93.94%,明显高于对照组(63.64%),差异有统计学意义(P < 0.05);两组患者治疗前各指标比较差异无统计学意义(P > 0.05);治疗后两组患者各指标均有明显下降(P < 0.05),但研究组血尿素氮(BUN)、空腹血糖(FPG)、白蛋白排泄率(UAER)明显低于对照组,差异有统计学意义(P < 0.05).结论前列地尔对于治疗糖尿病肾病具有较好的临床效果,能够有效提高对肾功能的修复和保护作用.%Objective To investigate the clinical curative effects of combined Alprostadil in the treatment of patients with diabetic nephropathy. Methods 66 cases admitted to our hospital from January 2010 to December 2010 were randomly divided into study group and control group, with 33 cases in each group. Both groups of patients received routine blood glucose reduction, diet control, protein intake limit and other basic treatment as well as oral administration of Captopril. Patients of the study group received additional Alprostadil on the basis. Results The total effective rate of the study group was 93.94%, which was significantly higher than 63.64% of the control group, with statistically significant difference (P 0.05); after the treatment, all the indicators of the two groups decreased significantly (P < 0.05), but blood urea nitrogen (BUN), fasting plasma glucose (FPG), urinary albumin excretion rate (UAER) of the study group were significantly lower than those of the control group, with statistically significant differences (P < 0.05). Conclusion Alprostadil shows good clinical curative effects in the treatment of diabetic

  18. Observation Curative Effect on Alprostadil Combine With Alpha Lipoic in Treatment of Diabetic Foot%前列地尔联合α-硫辛酸治疗糖尿病足疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴昌南

    2015-01-01

    Objective To explore the clinical effect of alprostadil combined with alpha lipoic in the treatment of diabetic foot. Methods Selected 90 cases with diabetic foot in our hospital as the research object, randomly divided into control group and treatment group, 45 cases in each group. Treatment group were treated with alprostadil combined with alpha lipoic treatment, the control group using the traditional treatment methods. Results The total effective rate of the treatment group was higher than that of the control group, P<0.05, had difference statistically significance. Conclusion Alprostadil combined with alpha lipoic acid in the treatment of diabetic foot can improve the treatment efifciency and the symptoms of patients with diabetic foot.%目的:探讨前列地尔联合α-硫辛酸治疗糖尿病足的临床疗效。方法选取我院收治的90例糖尿病足患者为研究对象,随机分成对照组和治疗组,每组各45例。治疗组采用前列地尔联合α-硫辛酸治疗,对照组采用传统的治疗方法。结果治疗组总有效率高于对照组, P<0.05,差异具有统计学意义。结论前列地尔联合α-硫辛酸治疗糖尿病足,可以有效地提高治疗的总有效率,改善糖尿病足患者的症状。

  19. 前列地尔联合缬沙坦治疗早期糖尿病肾病的临床观察%Alprostadil Valsartan Treatment of Early Diabetic Nephropathy

    Institute of Scientific and Technical Information of China (English)

    阿吉姑里•阿不都热衣木

    2013-01-01

    Objective Valsartan used in early diabetic nephropathy effect of alprostadil combined analysis. Methods Choose my hospital early diabetic nephropathy 78, divided into A, group B, group A, 33 patients of the control group, B group 45 patients for the treatment group were given valsartan drug treatment, and alprostadil Valerian sand randomlyTanzania method to heal. Results Lower in group A after healing, the glomerular filtration rate of the B group of objects, total urinary protein, urinary protein excretion efficient than in group A, the incidence of adverse reactions is lower than the A group. Conclusion Alprostadil combination of valsartan used in early diabetic nephropathy, patients recover better and have higher efficiency.%  目的 对前列地尔结合缬沙坦应用于早期糖尿病肾病效果加以分析。方法随机选择我院早期糖尿病肾病患者78名,分成A、B组, A组33名患者为对照组,B组45名患者为治疗组,分别给予缬沙坦药物医治,和前列地尔结合缬沙坦方法医治。结果经医治,B组对象肾小球滤过率、尿蛋白总量、尿蛋白排除量低于A组,有效率高于A组,不良反应发生率低于A组。结论前列地尔结合缬沙坦应用于早期糖尿病肾病,患者恢复较好,有效率较高。

  20. 缬沙坦联合前列地尔治疗糖尿病肾病的临床疗效研究%Clinical efficacy of valsartan combined with alprostadil in treatment of diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    太赛尔格林; 古力尼沙·艾塔洪

    2015-01-01

    目的:探讨缬沙坦联合前列地尔治疗糖尿病肾病的临床疗效。方法选择2012年6月~2014年6月确诊的64例糖尿病肾病患者,全部患者按1:1的比例完全随机分为研究组和对照组,每组32例,两组均予降糖、降压治疗,同时控制饮食及适量运动,对照组予缬沙坦片80 mg,每日1次,口服,连用4周,研究组同时加用前列地尔100μg,置入100 mL NaCl溶液中静滴,每日1次,连用4周。比较两组的临床总有效率以及治疗前后BUN、UAER、SCr各项观察指标的变化。结果治疗4周后比较两组疗效,研究组的总有效率为93.75%,与对照组的71.88%比较,差异有统计学意义(P<0.05)。两组BUN、UAER、SCr水平治疗后均较治疗前降低,且研究组治疗后BUN、UAER、SCr水平较对照组降低更显著(t=2.754、3.632、3.247,P<0.05)。结论缬沙坦联合前列地尔可以提高糖尿病肾病的临床疗效,改善肾功能,安全性好,值得推广和应用。%Objective To investigate the clinical efficacy of valsartan combined with alprostadil in treating diabetic nephropathy. Methods A total of 64 cases of diabetic nephropathy patients diagnosed from June 2012 to June 2014 ac-cording to the ratio of 1:1 in all patients were randomly assigned to study group and control group, 32 cases in each group, two groups were treated with hypoglycemic, antihypertensive therapy, meanwhile with diet and proper exercise, control group was treated with valsartan tablets 80 mg, 1 time, oral daily, for 4 weeks, the study group combined with alprostadil in 100 mL NaCl, solution 100 μg, intravenous drip, 1 time a day, for 4 weeks. The total efficiency of the two groups before and after treatment, and BUN, UAER, SCr indexes change of two groups were compared. Results The treatment efficacy of the two groups were compared after 4 weeks, the total efficacy rate of the study group was 93.75%, compared with the control group's 71.88%, the

  1. 硫辛酸对早期糖尿病足患者氧化应激与炎症反应的影响%Effect of alprostadil on oxidative stress and inflammation in patients with diabetic foot

    Institute of Scientific and Technical Information of China (English)

    徐松明; 许晓华; 孙云鹰; 金雯佳

    2015-01-01

    Objective To explore the effect of alprostadil on oxidative stress and inflammation in patients with diabetic foot.Methods Ninety diabetic foot patients were randomly divided into the observe group ( n=45)and the control group(n =45).They all accepted the conventional treatment, but the patients in the observed group were given the treatment of alprostadil capsules, 1 time 0.2 g, 3 times a day, for 4 weeks.The concentrations of superoxide dismutase ( SOD ) and malondialdehyde ( MDA) were detected by thiobarbituric acid reaction.The concentrations of advanced oxidation protein products ( AOPPs ) , vascular cell adhesion molecule-1 ( VCAM -1 ) , fibroblast growth factor 2 ( FGF -2 ) and tumor necrosis factor alpha ( TNF -alpha ) were detected by enzyme linked immunosorbent assay.And the concentration of interleukin -6 ( IL-6) was detected by the electrochemical luminescence method.The concentrations of SOD, MDA, AOPPs, VCAM-1, FGF-2, IL-6 and TNF-alpha were compared between the two groups before and after treat-ment.Results The efficiency in the observation group (84.44%) was significantly higher than that in control group (64.44%).After treatment, the AOPPs, MDA, VCAM -1, FGF2, TNF -alpha and IL-6 in the observation group were significantly lower than that in the control group ( P<0.05) , and the SOD in the observed group was significantly higher than that in the control group ( P <0.05 ).Conclusion Alprostadil couldimprove the clinical efficacy by improving oxidative stress and inflammation in diabetic foot patients.%目的:探讨硫辛酸对早期糖尿病足患者氧化应激、炎症反应的影响。方法90例糖尿病足患者随机分成观察组和对照组(均45例),2组常规治疗相同,在此基础上,观察组给予硫辛酸胶囊,1次0.2 g,1日3次,疗程为4周。用硫代巴比妥酸反应法检测超氧化物歧化酶(SOD)和丙二醛(MDA),用酶联免疫吸附法检测血清晚期蛋白氧化产物( AOPPs )

  2. 前列地尔与依那普利联合治疗早期糖尿病肾病的疗效%Effect of Alprostadil Combined Enalapril Treat Early Diabetic Nephropathy

    Institute of Scientific and Technical Information of China (English)

    李大勇

    2011-01-01

    目的:观察前列地尔(凯时注射液)联合依那普利治疗早期糖尿病肾病(DN) 的疗效.方法:将本院门诊和住院病人138 例早期DN 患者,随机均分为2组,2 组患者均接受糖尿病饮食、降糖、控制血压及调脂治疗,均服用依那普利10mg,每日1次.治疗组(n=69 例)在对照组基础上加用前列地尔注射液治疗,分别比较2组患者在治疗前后血压(MBP) 、空腹血糖(FBG) 、糖化血红蛋白(HbA1c) 、尿微量白蛋白排泄率(UAER) 、血肌酐(Scr) 、尿素氮(BUN) 的变化.结果:2 组在治疗前各项指标均无明显差异(P>0.05); 治疗2周后,2 组FBG 、HbA1c 、MAP 、BUN 无明显变化,24h-UAER 、Scr 较治疗前均明显好转;而治疗组的24h-UAER 较对照组改善更明显(P<0.01).结论:前列地尔联合依那普利治疗早期DN 疗效显著,能有效减少UAER,有利于延缓甚至防止糖尿病肾病的发生和发展,值得临床推广和应用.%Objective:TO observe the early effect of Alprostadil (Kaishi injection)combined Enalapril in treating early diabetic nephropathy.Methods: Divide 138 patients with early diabetic nephropathy into two groups randomly, two groups of patients accept diabetes diet,control blood sugar, control blood pressure and adjusting blood-fat. They both be treated with Enalapril 10mg, one time a day. At the basic treatment of control group(69 cases), therapy group(69 cases), be treated with Alprostadil 10 μ g one time a day.Receive the same treatment for two weeks without a stop.Changes before and after treatment in levels of blood pressure,FBG, HbA1C,urine albumin excretion rate(UAER), Scr and BUN were observed and compared between the two groups. Results: The two groups showed similar levels of the indexes at baseline (P>0.05). After two weeks' treatment,UAER and Scr were significantly improved in two groups(P<0.05). Compared with the control group,the therapy group showed greater improvement in UAER(P<0.01); MBP, BUN, FPG and HbA1C

  3. 前列地尔治疗糖尿病下肢动脉粥样硬化闭塞症疗效观察%The clinical observation of DB artery of lower extremity scleratheroma block system by alprostadil

    Institute of Scientific and Technical Information of China (English)

    郝云玲; 龚志强

    2012-01-01

    Objective To observe clinical effect of alprostadil on DB artery of lower extremity scleratheroma block system patients.Methods To retrospectively analyze clinical data of lower extremity scleratheroma block system patients in our hospital,which were divided into detection group and control group.Results The bore 、blood flow and Vdias of femoral artery、popliteal artery、arteria tibialis posterior and dorsal artery of foot of detection group were better than control group,the clinical total effective rate of detection group was higher than control group (P < 0.05 ),the difference was statistically significant.Conclusion The clinical curative effect of DB artery of lower extremity scleratheroma block system by alprostadil was obviously,which was worthy to be used.%目的 观察前列地尔治疗糖尿病下肢动脉粥样硬化闭塞症的临床疗效.方法 回顾性分析110例糖尿病下肢动脉粥样硬化闭塞症患者临床资料,依据治疗方式不同分为观察组80例(常规治疗联合前列地尔)和对照组30例(常规治疗),比较两组治疗效果.结果 观察组股动脉、腘动脉、胫后动脉及足背动脉的血管内径、血流量、血流峰时速度均明显优于对照组(均P <0.05),观察组临床总有效率为100.0%,明显高于对照组的86.7%(x2=11.069,P<0.05).结论 前列地尔治疗糖尿病下肢动脉粥样硬化闭塞症疗效明显,值得临床推广应用.

  4. Effect of alprostadil on patients with acute kidney ynjury%前列地尔治疗急性肾损伤疗效观察

    Institute of Scientific and Technical Information of China (English)

    李文宁; 詹锋; 武伟; 林书典

    2012-01-01

    目的 探讨前列地尔(PGE1)治疗急性肾损伤(Acute Kidney Injury,AKI)的临床疗效.方法 收集海南省人民医院肾病风湿科自2010年1月~2012年1月住院治疗的急性肾损伤患者56例,随机分为治疗组(28例)和对照组(28例).两组常规用药相同,治疗组加用PGE1静脉滴注,每天1次,连续2周.比较两组患者治疗前后尿NAG酶、尿渗透压、血肌酐、尿素氮、尿β2微球蛋白以及肾衰指数、肾小球滤过率及进入透析人数的变化.结果 治疗组治疗后,尿NAG酶、血肌酐、尿素氮、尿β2微球蛋白以及肾衰指数明显低于对照组,尿渗透压、肾小球滤过率明显高于对照组(P<0.05).治疗组进入透析的人数(6人)低于对照组(13人)(x2=3.9,P< 0.05).结论 PGE1可促进AKI缓解,增强疗效.%Objective To observe the effect of alprostadil (PGE1) on patients with acute kidney injury (AKI). Methods The 56 patients, definitely diagnosed as AKI in Department of Nephrology and Rheumatology of Hainan Provincial People's Hospital during Jan 2010 to Jun 2012, were randomly divided into treatment group (28 patients) and control group (28 patients). All the patients in two groups were received the basic therapy, PGE1 at dose of 10μg ivgtt qd was added to those in the treatment group for two weeks. The urine osmotic pressure and levels of urinary NAG enzyme, serum creatinine, blood urea nitrogen, urine beta 2 microglobulin and renal failure index and glomerular filtration rate in the two groups were determined and compared before and after treatment. Results In the treatment group before and treatmernt the levels of Bun were 34.56± 4.61mmol/L,10.33±2.11mmol/L,Cr were 284.17±10.86μmol/L, 125.85±29.01μmol/L, Urinary NAG60 were 4±20.4U/L, 24.09± 5.86U/L, Urine osmotic pressure were 495.85±32.42mmol/L, 795±103.41mmol/L,Urine β2 microglobulin 1 were 26±0.52mg/L、 0.54±0.14mg/L,Renal failure indexl.9±0.82, 0.8±0.31,Glomerular filtration rates were 82±7

  5. 褪黑素联合前列地尔在急性胰腺炎中的作用研究%Clinical study on melatonin combined with alprostadil in the treatment of patients with acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    赵亮; 郭帅; 白黎智

    2011-01-01

    Objective To observe the results of melatonin combined with alprostadil in the treatment of patients with acute pancreatitis.Methods Seventy patients with acute pancreatitis were included in the study,14 patients died after conventional treatment were set to group Ⅰ ,28 patients cured after conventional treatment were set to group Ⅱ and 28 cases cured after melatonin combined with alprostadil and conventional treatment were set to group Ⅲ.White blood cell count,blood gas analysis,serum amylase,endotoxin and malondialdehyde (MDA) content was detected at 6 h,48 h and 4 d.Results White blood cell count,serum amylase,endotoxin,MDA content at 6 h,48 h and 4 d in group Ⅰ were higher than those in group Ⅱ ,Ⅲ (P<0.05).Endotoxin levels reached a maximum in the 4 d [(273.5 ± 20.4) pg/L],and MDA content reached a maximum in the 4 d [(5.12 ± 0.87) μmol/L].White blood cell count,partial pressure of carbon dioxide in artery (PaCO2),serum amylase,endotoxin and MDA content at 48 h,4 d in group Ⅲ were lower than those in group Ⅰ,Ⅱ (P <0.05).Conclusions Melatonin combined with alprostadil not only shows antioxidant,anti-inflammatory,anti-apoptotic effect but also improves the pancreas,lung,small intestine microcirculation,protects the cell membrane and the lysosomal membrane,and prevents effectively the pancreatic digestive enzymes release; also it inhibits intestinal bacterial translocation,reduces the generation of gut-derived endotoxin and pro-inflammatory cytokine release.It can reduce effectively the systemic inflammatory response in acute pancreatitis.%目的 观察褪黑素联合前列地尔在急性胰腺炎患者中的治疗效果.方法 急性胰腺炎患者70例,常规治疗后死亡14例设为Ⅰ组,经常规治疗后治愈28例设为Ⅱ组,褪黑素联合前列地尔+常规治疗治愈28例设为Ⅲ组.每组再按6h、48 h、4d时问点采血,检测白细胞计数、血气分析、血淀粉酶、内毒素及丙二醛(MDA)的含量.结果 Ⅰ组6

  6. Effect of alprostadil injection on vascular endothelial function in early diabetic retinopathy patients%前列地尔对早期糖尿病视网膜病变患者血管内皮功能的影响

    Institute of Scientific and Technical Information of China (English)

    卢伟波; 李舒敏; 吕以培; 黄中莹; 杨丕坚

    2013-01-01

    目的 观察前列地尔对早期糖尿病视网膜病变(DR)患者血管内皮功能变化的影响,并探讨其可能的机制.方法 选择早期DR患者63例(观察组),分为A组31例和B组32例,两组均常规予人胰岛素治疗,A组静脉注射前列地尔10 μg,1次/d,共用3周;另选体检健康者31例作为对照组.检测对照组及观察组治疗前后的空腹血糖(FBG)、糖化血红蛋白(HbA1C)、甘油三脂(TG)、总胆固醇(TC)、细胞间黏附分子1(ICAM-1)、超敏C反应蛋白(hs-CRP)及血内皮素1(ET-1),超声检测肱动脉血流介导的内皮依赖性血管舒张功能(FMD).结果 观察组治疗前FBG、HbA1C、TG、TC、ICAM-1、hs-CRP及ET-1均高于对照组(P均<0.05),FMD较对照组降低(P<0.05);A组治疗后外周血ET-1为(96.69 ±10.68) pg/mL、ICAM-1为(403.83±87.48) ng/mL、hs-CRP为(8.77±1.27) mg/L、FMD为11.89% ±3.58%,B组分别为(184.6±10.79)pg/mL、(597.78±60.75) ng/mL、(18.79 ±2.43) mg/L、9.18% ±0.55%;两组比较,P均<0.05.结论 前列地尔能有效改善早期DR患者的血管内皮功能,该作用与其降低血ICAM-1、hs-CRP、ET-1水平有关.%Objective To observe the effect of alprostadil injection on the changes of vascular endothelial function in early diabetic retinopathy patients and to investigate the possible mechanism.Methods Sixty-three cases of patients with early diabetic retinopathy (observation group) were divided into group A (31 cases) and group B (32 cases).Two groups were treated with human insulin and group A was treated with alprostadil injection (10 ug iv q.d.) for 3 weeks.Another 31 healthy subjects were selected as controls (the control group).The levels of fasting blood glucose (FBG),glycosylated hemoglobin (HbA1c),triglyceride (TG),cholesterol (TC),intercellular adhesion molecule-1 (ICAM-1),high sensitivity C-reactive protein (hs-CRP),and endothelin-1 (ET-1) were measured respectively before and after treatment in the control group and observation

  7. Therapeutic effect of alprostadil combined with sulodexide in treatment of stage-Ⅳ diabetic nephropathy%前列地尔联合舒洛地特治疗Ⅳ期糖尿病肾病的疗效观察

    Institute of Scientific and Technical Information of China (English)

    张海红; 谭晓军

    2015-01-01

    目的:观察前列地尔联合舒洛地特治疗Ⅳ期糖尿病肾病的疗效。方法收集2014年1月至11月本科室住院的Ⅳ期糖尿病肾病患者86例,随机数字法分为治疗组(n=45)与对照组(n=41)。两组患者均进行严格糖尿病饮食控制,口服舒洛地特250 LSU,2次/d;14 d后治疗组此基础上加用前列地尔20μg加入生理盐水100 ml中静脉滴注,2次/d,持续10 d后结束治疗。治疗前后两组患者的收缩压、舒张压、糖化血红蛋白、血清肌酐、尿微量白蛋白、尿蛋白定量、尿白蛋白排泄率等指标进行组内和组间比较。结果治疗前两组患者的收缩压、舒张压、糖化血红蛋白、血清肌酐、尿微量白蛋白、尿蛋白定量、尿白蛋白排泄率差异均无统计学意义(均P>0.05)。与治疗前比较,治疗后两组患者的尿微量白蛋白、尿蛋白定量、尿白蛋白排泄率均降低(均P0.05). After treatment,the both groups showed reduction in microalbuminuria,urinary protein quantity and UAER, as compared with pretreatment(all P<0.05);and compared with the control group,the treatment group show more dramatical reduction in these indexes (all P<0.05). Conclusion Combination treatment with alprostadil and sulodexide for diabetic nephropathy can be more effective in improving the patient outcomes.

  8. The clinical observation of the efficacy of mecobalami, alprostadil, and extract of ginkgo biloba leaves combination therapy in elderly diabetic peripheral neuropathy%弥可保、凯时和金纳多联合治疗老年糖尿病周围神经病变的临床观察

    Institute of Scientific and Technical Information of China (English)

    王炜; 王晓湘; 张汝; 李改丽; 王建

    2012-01-01

    目的 了解弥可保、凯时和金纳多联合治疗在改善糖尿病患者周围神经疼痛及感觉异常方面的作用,为临床治疗糖尿病周围神经病变提供参考.方法 以老年Ⅱ型糖尿病患者伴周围神经病变为研究对象,给予弥可保、凯时和金纳多联合治疗,动态观察患者的局部神经疼痛、感觉异常和神经传导速度的改善情况.结果 共纳入54例临床诊断为Ⅱ型糖尿病伴周围神经病变的患者.在给予联合治疗4周后,54例患者中分别有24例(44.4%)和25例(46.3%)患者的局部自发痛或(和)感觉异常缓解程度达到了临床显效和有效的标准,而仅5例(9.3%)患者的局部不适无改善.结论 弥可保、凯时和金纳多联合治疗对改善老年糖尿病周围神经病变疗效显著.%Objective To investigate the efficacy of mecobalami, alprostadil, and extract of ginkgo biloba leaves combination therapy in reducing pain and paresthesia of diabetic patients and provide a reference for the clinical treatment of diabetic peripheral neuropathy. Methods The elderly type 2 diabetic patients with peripheral neuropathy were given mecobalami, alprostadil, and extract of ginkgo biloba leaves treatment, and the improvement of local nerve pain, paresthesia and nerve conduction velocity were dynamically observed. Results A total of 54 elderly type 2 diabetic patients with peripheral neuropathy were included in this study. After giving 4 weeks of combination therapy, there were 24 (44. 4%) and 25 (46. 3%) patients respectively, whose local spontaneous pain or paresthesia remission degree reached to markedly effective standard and effective standard; and only 5 patients had no improvement on local discomfort. Conclusion The combination therapy of mecobalami, alprostadil, and extract of ginkgo biloba leaves could significantly improve the remission of diabetic peripheral neuropathy.

  9. Effectiveness of alprostadil on insulin resistance index, brain natriuretic peptide and nuclear factor-κB in 2 diabetic patients combined with heart failure%前列地尔对2型糖尿病合并心力衰竭患者胰岛素抵抗、血脑钠肽和核因子-κB的影响

    Institute of Scientific and Technical Information of China (English)

    杜茜; 秦玲

    2012-01-01

    目的 探讨前列地尔对2型糖尿病合并心力衰竭患者胰岛素抵抗、血脑钠肽和核因子-κB的影响.方法 选取住院治疗的糖尿病合并心力衰竭患者80例,采用抽签法随机分为对照组(n=40)和治疗组(n=40).在维持血糖、血压、血脂达标的情况下,对照组给予常规抗心力衰竭治疗,包括一般治疗与药物治疗,治疗组在此基础上加用前列地尔20 pg,每日1次,共2周.治疗前后留取空腹血液标本,检测脑钠肽、核因子-κB,借助心脏超声检查评价患者心功能,计算胰岛素抵抗指数.结果 治疗后,两组患者左心室射血分数、胰岛素抵抗指数、脑钠肽、核因子-κB均显著改善,并且胰岛素抵抗指数、脑钠肽、核因子-κB较对照组改善更好,差异有统计学意义(P<0.05).结论 前列地尔可显著增强2型糖尿病合并心力衰竭患者射血分数,纠正胰岛素抵抗,减少脑钠肽和核因子-κB的表达,进而改善患者的临床症状及预后.%OBJECTIVE To study the effectiveness of alprostadil on insulin resistance index (IR) , brain natriuretic peptide (BNP) and nuclear factor— κB (NF-κB) in 2 diabetic patients combined with heart failure (HF). METHODS Eighty 2 diabetic patients combined with HF were enrolled and randomly assigned to the control group (n = 40) and the treatment group (n = 40). In keeping glucose, blood pressure and lipid to reach purpose, subjects of the control group received routine treatment. Those of the treatment group additionally had 20pg alprostadil once per day for two weeks. Left ventricular ejection fraction (LVEF), IR, BNP and NF-kB were tested before and after the intervention. RESULTS After the intervention, 6 — Illinute walking test (6MWT). LVEF, IR, B NP and NF-κB were significantly improved in both groups. IR BNP and NF-κB in treatment group were supior to those in control group. CONCLUSION Alprostadil may be able to significantly improve myocardium LVEF, correct

  10. 凯时对急性脑梗死患者血清丙二醛、超氧化物歧化酶、过氧化氢酶水平的影响%Effect of Alprostadil injection on serum MDA, SOD and CAT in patients witha cute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    颜玮茹; 廖春梅

    2015-01-01

    目的:观察前列地尔注射液对急性脑梗死患者血清过氧化氢酶( CAT)、丙二醛( MDA)、超氧化物歧化酶( SOD)的影响,探讨其神经保护作用机制。方法将120例急性脑梗死患者随机分为实验组和对照组,每组60例,同时选取健康体检者60例作为健康组。实验组给予前列地尔注射液静滴,对照组给予丹参注射液静滴,均1次/d,连用10 d。在治疗前及治疗3,7,14 d测定血清中MDA、SOD和CAT水平,并对患者进行欧洲卒中评分( ESS)及日常生活能力Barthel指数( BI)疗效评定。结果实验组和对照组治疗前MDA水平高于健康组(P<0.01),SOD、CAT水平低于健康组(P均<0.01)。对照组治疗后MDA水平无明显变化(P>0.05),实验组MDA治疗后明显低于治疗前(P<0.05)。实验组治疗后血清SOD、CAT活力逐渐上升,均明显高于对照组(P均<0.05)。实验组治疗后第7天、第14天ESS和BI评分均优于对照组(P均<0.05)。结论前列地尔注射液通过降低血清MDA含量,提高CAT和SOD活性,从而改善神经细胞功能。%Objective It is to observe the effect of Alprostadil injection on serum malondialdehyde(MDA),superoxide dis-mutase(SOD) and catalase(CAT) in patients with acute cerebral infarction, and discuss the nerve protection mechanism. Methods 120 cases with acute cerebral infarction were randomly divided into experimental group and control group, 60 cases in each group, and 60 cases of healthy persons were selected as healthy group.The experimental group was given Alprostadil intravenous drip infusion and the control group was given Danshen injection by intravenous drip infusion once per day, and both groups were treated for 10 days.The serum levels of MDA, SOD and CAT were measured before treatment and after treat-ment for 3 days, 7 days and 14 days.Therapeutic efficacy was evaluated by the European Stroke Scale( ESS

  11. Effect of alprostadil combined wih glycyrrhizin in treatment of severe chronic cholestatic hepatitis B and its affect on serum biochemical indexes%前列地尔联合复方甘草酸苷治疗重度慢性乙型肝炎合并淤胆的疗效及对血清生化指标的影响

    Institute of Scientific and Technical Information of China (English)

    张海燕; 范晖

    2014-01-01

    目的:探讨前列地尔联合复方甘草酸苷治疗重度慢性乙型肝炎合并淤胆的临床疗效。方法将92例重度慢性乙型肝炎合并淤胆患者采用数字表法随机分为两组,两组均给予复方甘草酸苷注射液,另外观察组在此基础上加用前列地尔,比较两组临床疗效及血清生化指标变化。结果观察组总有效率为89.13%,显著高于对照组(76.09%)(χ2=7.83,P<0.05);观察组治疗后总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(γ-GT)和碱性磷酸酶(AKP)指标分别为(68.78±7.82)μmol/L、(54.64±6.68)μmol/L、(64.57±8.97)IU/L、(59.62±7.34)IU/L和(60.23±8.22)IU/L,均显著低于治疗前[(265.63±11.78)μmol/L、(138.49±11.29)μmol/L、(557.62±21.23)IU/L、(157.72±10.31)IU/L 和(170.38±11.20)IU/L](t=11.23、10.42、10.63、9.88、10.68,P<0.05)和对照组[(153.68±8.62)μmol/L、(137.44±9.31)μmol/L(、152.02±12.33)IU/L(、114.82±9.21)IU/L和(106.83±9.01)IU/L](t=8.38、8.01、7.92、8.30、7.20,P<0.05)。结论前列地尔联合复方甘草酸苷治疗重度慢性乙型肝炎合并淤胆具有显著疗效。%ObjectiveTo investigate the effect of alprostadil combined wih glycyrrhizin in treatment of severe chronic cholestatic hepatitis B.Methods92 patients with severe chronic cholestatic hepatitis B combined were divided into two groups by using a random number table metod. Two groups were given glycyrrhizin injection while the observation group were treated with alprostadil in addton. The clinical efifcacy and serum biochemical parameters changes were compared between the two groups.ResultsThe observation group's total effective rate was 89.13%, signiifcantly higher than the control group's 76.09% (χ2=7.83,P<0.05);The observation group's indicators of TBIL, DBIL, ALT, γ-GT and AKP after treatment were (68

  12. Effects of alprostadil and ulinastatin on Inflammatory response and lung injury after cardiopuhnonary bypass in pediatric patients with congenital heart diseases%前列地尔联合乌司他丁对小儿体外循环后炎性反应和肺损伤的影响

    Institute of Scientific and Technical Information of China (English)

    蒋懿斐; 王文伟; 叶文炼; 倪育飞; 李军; 陈小玲; 金胜威; 连庆泉

    2008-01-01

    目的 观察前列地尔和(或)乌司他丁(Ulinastatin)对小儿体外循环后炎性反应的影响及其肺保护作用.方法 选择择期行体外循环下房室缺修补术患儿58例.随机分为4组:对照组(C组14例)、前列地尔组(P组15例)、乌司他丁组(U组15例)、前列地尔联合鸟司他丁组(PU组14例).观察患儿血流动力学变化,总机械通气时间和ICU留治时间.麻醉诱导后CPB前(T、)、主动脉开放30 min(T2)、2 h(T3)、6 h(T4)、24 h(T5)5个时点采集桡动脉血测最中性粒细胞(PMN),血浆中白细胞介素(IL)-6、IL-8、IL-10、肿瘤坏死因子(TNF)-α和基质金属蛋白酶-9(MMP-9)的含量.于T1、T2、T2记录吸入氧浓度和动脉血气计算肺泡氧合指数(OI).结果 与C组比较,其他3组在T2、T3时PMN、IL-6、IL-8、TNF-α的水平明显降低(均P 0.05). The umbers of PMN and the levels of IL-6, IL-8, and TNF-α at T2 and T3 of Groups P,U, and PU were all significantly lower than that of Group C (all P 0.05). The Ols at T2 of Groups P, U, and PU were significantly higher than that of Group C (all P < 0.05). The mechanical ventilation time of Groups P, U, and PU were all significantly shorter than that of Group C, and that of Group PU was significantly shorter than that of group C (P < 0.05). Conclusion Decreasing the inflammatory response after CPB, alprostadil and ulinastatin used during CPB effectively reduce the pulmonary injury via inhibition of the neutrophil activation and cytokines release.

  13. Evaluate of the Equivalence and Safety of Two Dosage Form of Alprostadil Injection in Patients with Diabetic Lower Extremity Arterial Occlusive Dis-ease by a Clinical Multi-Centre Trial%两种前列地尔注射液治疗糖尿病下肢动脉闭塞症的等效性和安全性比较研究

    Institute of Scientific and Technical Information of China (English)

    张星光; 虞冠锋; 冉兴无; 刘福平; 吕肖锋; 朱旅云; 刘俊江; 吕伯南; 刘超; 刘长建; 王立明

    2015-01-01

    目的:观察2种前列地尔注射液在治疗糖尿病下肢动脉闭塞症(糖尿病足)的等效性和安全性。方法:采用随机双盲、阳性药平行对照、多中心临床研究。试验组使用前列地尔脂微球注射液,对照组使用前列地尔注射液。疗程均为14 d。结果:随机入组235例受试者。对照组入选117人,试验组118人。主要疗效指标中踝肱比值,全分析数据集(full analysis set,FAS)人群组内比较:两组治疗14 d后踝肱比值均较基线时有所提高,且有统计学意义。组间比较:治疗14 d后对照组提高0.09;试验组提高0.10,两组间无统计学意义,符合方案数据集(per-protocol set, PPS)人群结果趋势和FAS一致。两组治疗14 d后静息痛均较基线时有所下降,且有统计学意义,组间比较无统计学差异,PPS人群结果趋势和FAS一致。最大无痛行走距离在两组间无统计学意义,PPS 结果和FAS一致。全部不良事件发生率对照组为19.33%;试验组为17.65%。相关不良事件对照组10.08%;试验组为8.4%;差别无统计学意义。结论:2种前列地尔注射液在治疗慢性下肢动脉闭塞性疾病的过程中,表现出相同的疗效和安全性。%Objective: To compare the equivalence and safety between reference preparation and test preparation of alprostadil injection in patients with chronic lower extremity arterial occlusive disease (LEAOD). Methods: It was a random, blind, multicentre and controlled clinical pharmaceutical trial. All subjects were divided into two groups and each of group. The test and reference preparations of alprostadil injections by different companies were given via the same administration route. Results: Eight hospitals in China and 235 volunteers were involved in the study, and 117 patients received the reference preparation and 118 received the test preparation. The ankle brachial index of both groups increased significantly

  14. Effect of alprostadil injection on lung injury in patients with paraquat poisoning%前列地尔注射液对百草枯中毒患者肺损伤的影响

    Institute of Scientific and Technical Information of China (English)

    吕望; 陈新国; 金焕治; 张雪良

    2012-01-01

    AIM: To investigate the association between the CalpainlO gene polymorphism and the risk of PTDM in Chinese renal allograft recipients. METHODS; Three single nucleotide polymorphisms (CAPN10 gene SNP-19, SNP-43, SNP-63) were genotyped in the cohort, which consisted of 97 renal allograft recipients with PTDM (PTDM group) and 301 renal allograft recipients without PTDM ( control group). The genotypes of polymorphisms were performed by allele specific polymerase chain reaction ( ASPCR ) , PCR-restriction fragment length polymorphism (PCR-RFLP). Logistic regression test was used to identify risk factors for PTDM development and calculate the odds ratio, RESULTS: The 11 and 12 genotypes of SNP-19 and the GG genotypes of SNP-43 were more common in patients with PTDM than those without PTDM (F<0. 05). After adjustments for age, sex, body weight and BMI, the effect of genotype remained significant (11 vs 22, OR = 1.502, 95%CI: 1.016-2.347, P = 0.048; 12 vs 22, OR=1. 764, 95%CI: 1.055 -2.947, P =0. 030) in SNP-19 and the patients carrying gen otype GG had higher risk comparison with carriers with genotype AA or GA(OR = 2. 190, 95% CI: 1.047 -3.473, P = 0. 044) in SNP-43. But SNP-63 was not association with PTDM. CONCLUSION; The 1-allele in SNP-19 and GG genotype in SNP-43 of CAPN10 gene are the independent risk factors of PTDM in Chinese renal allograft recipients.%目的:观察前列地尔注射液对百草枯中毒患者炎症介质和肺损伤的影响,为临床治疗提供参考.方法:30例急性百草枯中毒患者随机分为常规治疗组(对照组)和常规治疗+前列地尔注射液组(试验组),每组15例.前列地尔注射液用法:10 μg加入100 mL生理盐水(NS)静脉滴注,1次/d,连用7d.分别于入院当天及入院后7d测定患者血浆IL-6、IL-8、基质金属蛋白酶-9(MMP-9)浓度,行动脉血气分析和胸部X线检查,并随访生存情况.结果:与对照组比较,入院后7d试验组患者IL-6、IL-8、MMP-9浓度降低,急性肺损伤(ALI)及全身炎症反应综合症发生率降低(P<0.05);两组患者病死率差异无统计学意义(P>0.05).结论:前列地尔注射液可减轻百草枯中毒患者炎症反应和肺损伤.

  15. Treatment of infertility in men with spinal cord injury

    DEFF Research Database (Denmark)

    Brackett, N.L.; Lynne, C.M.; El Dib, Hussein Ibrahim El Desouki Hussein;

    2010-01-01

    Most men with spinal cord injury (SCI) are infertile. Erectile dysfunction, ejaculatory dysfunction and semen abnormalities contribute to the problem. Treatments for erectile dysfunction include phosphodiesterase type 5 inhibitors, intracavernous injections of alprostadil, penile prostheses...

  16. 突发性耳聋的椎-基底动脉DSA表现及经椎动脉内灌注前列地尔治疗的初步研究%Digital Subtraction Angiography Abnormalities in 30 Adults with Sudden Sensorineural Hearing Loss and Evaluation of Alprostadil Injection Into the Vertebral Artery

    Institute of Scientific and Technical Information of China (English)

    刘源; 张勤修; 邓晓筑; 周立; 谢慧; 何春水; 廖华强; 刘洋; 张丽峰; 曾伟

    2010-01-01

    目的 分析突发性耳聋(sudden sensorineural hearing loss,SSNHL)患者椎-基底动脉系统DSA的表现特点及经椎动脉灌注前列地尔的疗效.资料与方法 对30例SSNHL患者分别在两侧椎动脉行DSA检查,分析椎动脉、基底动脉、小脑前下动脉(AICA)、内听动脉的影像学表现,然后经导管在椎动脉灌注前列地尔(平均剂量5μg,灌注时间5 min).术后1周复查听力,观察听力改善情况.结果 30例均成功进行上述检查、治疗,无相关并发症出现.30例中,2例出现一侧椎动脉闭塞,5例椎动脉硬化.分别有23.3%(7/30)的右侧AICA和30.0%(9/30)的左侧AICA呈现缺失或细小改变,63.3%(19/30)的右侧内听动脉和73.3%(22/30)的左侧内听动脉呈现缺失或细小改变.术后纯音听阈测试显示听阈水平(500 Hz、1000 Hz、2000 Hz、4000Hz听阈的平均值)平均升高28.2 dBHL,其中痊愈2例,显效8例,有效15例,无效5例,总有效率83.3%.结论 SSNHL与内听动脉、AICA细小、缺失导致的内耳缺血有关,灌注扩张血管的药物能够改善症状,提高听力.

  17. Clinical effect observation of alprostadil with early hyperbaric oxygen in the treatment of sudden deafness and tinnitus%前列地尔配合早期高压氧治疗突发性耳聋耳鸣的临床效果观察

    Institute of Scientific and Technical Information of China (English)

    黄员福; 薛梅; 欧锦添; 李建美

    2014-01-01

    目的 探讨前列地尔配合早期高压氧治疗突发性耳聋耳鸣的临床效果.方法 收集2012年10月~2014年3月来本院就诊的突发性耳聋耳鸣患者72例,按照随机数字表法分为两组,研究组及对照组各36例,研究组采用前列地尔配合早期高压氧治疗;对照组采用葛根素治疗,比较两组纯音测听气导情况及临床效果.结果 研究组及对照组治疗后纯音测听气导平均值与治疗前比较均有不同程度的降低,研究组治疗后降低的幅度高于对照组,差异有统计学意义(P<0.05),研究组治疗突发性耳聋的总有效率(88.89%)、耳鸣总有效率(87.5%)高于对照组(77.78%、73.91%),差异有统计学意义(P<0.05).结论 前列地尔配合早期高压氧治疗突发性耳聋耳鸣的效果较好,可以显著改善纯音测听气导平均值,提高治疗总有效率.

  18. In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

    Science.gov (United States)

    Biro, Katalin; Sandor, Barbara; Toth, Andras; Koltai, Katalin; Papp, Judit; Rabai, Miklos; Toth, Kalman; Kesmarky, Gabor

    2014-05-01

    Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheological parameters were defined as risk factors in a number of studies and several therapeutic agents were tried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effects of various drugs generally used in the parenteral treatment of intermittent claudication and critical limb ischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline, sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit (Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV) were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassisted optical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuring erythrocyte deformability at 37°C. Iloprost, alprostadil, and pentoxifylline incubation did not have any significant effect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadil at low shear stresses 0.95 and 0.53 Pa (p pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratio and deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheological parameter; alprostadil may improve a microrheological parameter. Hemorheological alterations could be important in PAD patients with hampered vasodilator capacity.

  19. The Application of Fluorescence Optical Imaging in Systemic Sclerosis

    Directory of Open Access Journals (Sweden)

    Alexander Pfeil

    2015-01-01

    Full Text Available Objective. The aim of this study was to visualize soft tissue inflammation using FOI on patients with Systemic Sclerosis (SSc characterized by SSc-related Raynaud’s phenomenon and to detect the therapeutic response to treatment with iloprost or alprostadil. Methods. Twenty-one patients with SSc and Raynaud’s phenomenon and twenty-six healthy controls were prospectively included. The SSc patients were intravenously treated with iloprost or alprostadil over seven days. FOI was performed at baseline and after seven days using an intravenous application of indocyanine green (ICG. The hands were divided into nineteen segments per hand. All segments were quantitatively evaluated to determine changes in ICG. Results. The sensitivity and specificity of FOI in the detection of ICG enhancement in patients with SSc were 95% versus 96%. At baseline, 31.5% hand segments showed ICG enhancement. After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%. Conclusion. The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity. The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil. FOI offers promising benefits in the diagnosis and therapy of patients with SSc-associated Raynaud’s phenomenon.

  20. Treatment of infertility in men with spinal cord injury

    DEFF Research Database (Denmark)

    Brackett, N.L.; Lynne, C.M.; El Dib, Hussein Ibrahim El Desouki Hussein;

    2010-01-01

    Most men with spinal cord injury (SCI) are infertile. Erectile dysfunction, ejaculatory dysfunction and semen abnormalities contribute to the problem. Treatments for erectile dysfunction include phosphodiesterase type 5 inhibitors, intracavernous injections of alprostadil, penile prostheses...... dysfunction and abnormal semen constituents contribute to the problem. Despite abnormalities, sperm from men with SCI can successfully induce pregnancy. In selected couples, the simple method of intravaginal insemination is a viable option. Another option is intrauterine insemination. The efficacy...

  1. MRI of the penis

    OpenAIRE

    Kirkham, A

    2012-01-01

    MRI of the penis is an expensive test that is not always superior to clinical examination or ultrasound. However, it shows many of the important structures, and in particular the combination of tumescence from intracavernosal alprostadil, and high-resolution T2 sequences show the glans, corpora and the tunica albuginea well. In this paper we summarise the radiological anatomy and discuss the indications for MRI. For penile cancer, it may be useful in cases where the local stage is not apparen...

  2. Prostaglandin E1 treatment in ductus dependent congenital cardiac malformation. A review of the treatment of 34 neonates

    DEFF Research Database (Denmark)

    Høst, A; Halken, S; Kamper, J;

    1988-01-01

    Thirty-four sick neonates with major duct dependent cardiac defects were given short term (1 h-408 h) intravenous infusions of prostaglandin E1 (alprostadil) in doses varying between 0.1 micrograms/kg/min (starting dose) and 0.01 micrograms/kg/min. The aim of the study was to establish an effecti.......05 micrograms/kg/min. A starting dose of 0.05 micrograms/kg/min with subsequent reduction is recommended, but in case of institution of treatment before transfer to a pediatric cardiac centre a lower starting dose of 0.01 micrograms/kg/min may be preferred....

  3. Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair

    Directory of Open Access Journals (Sweden)

    Sibel Naska

    2016-01-01

    Full Text Available Here, we asked whether we could identify pharmacological agents that enhance endogenous stem cell function to promote skin repair, focusing on skin-derived precursors (SKPs, a dermal precursor cell population. Libraries of compounds already used in humans were screened for their ability to enhance the self-renewal of human and rodent SKPs. We identified and validated five such compounds, and showed that two of them, alprostadil and trimebutine maleate, enhanced the repair of full thickness skin wounds in middle-aged mice. Moreover, SKPs isolated from drug-treated skin displayed long-term increases in self-renewal when cultured in basal growth medium without drugs. Both alprostadil and trimebutine maleate likely mediated increases in SKP self-renewal by moderate hyperactivation of the MEK-ERK pathway. These findings identify candidates for potential clinical use in human skin repair, and provide support for the idea that pharmacological activation of endogenous tissue precursors represents a viable therapeutic strategy.

  4. 功能核磁共振成像法评价妇女局部应用前列腺素E1乳膏的脑局部反应%Functional magnetic resonance imaging method in evaluating women's local cerebral response for local application of Prostaglandin E1 cream

    Institute of Scientific and Technical Information of China (English)

    张渺; 廖秦平; 谢晟; 李雪迎; 高雪莲; 吕明启

    2013-01-01

    目的:通过功能性核磁共振扫描(fMRI)评价在视觉刺激条件下在阴蒂和G点涂抹前列腺素E1乳膏后的脑激活状态.方法:健康妇女及性唤起障碍妇女各5名,进行随机、双盲、安慰剂交叉对照研究.每一位受试者随机应用前列腺素E1乳膏或安慰剂乳膏,两次访视间隔7天的清洗期.通过fMRI评价脑区域的激活状态.结果:在健康组中,药物强于安慰剂的区域为左侧额上回、右侧前额叶,但是在双侧顶叶位置较弱;在患者组中药物组的激活状态在右侧顶叶较安慰剂减弱.前列腺素E1在健康组左侧前语言区、右侧岛叶、左后扣带回和右侧顶叶的激活状态高于患者;在左侧梭状回、右侧前额叶、左侧额上回患者的激活效应高于健康组.结论:前列腺素E1乳膏的作用是性刺激依赖的.右侧前额叶、左侧额上回是与药物效应有关的激活脑区,患者和健康人之间的脑部不同激活模式可能与病因有关.%Objectives: To explore the cerebral activation patterns by using functional magnetic resonance imaging during visual sexual stimulalion after application of alprostadil cream to the clitoris and G-spot. Methods, This study was designed with a random group separation, double ?blind and cross ?over mechanism and a placebo ?controlled comparison. A total of 5 healthy and 5 FSAD women randomly applied the alprostadil or the placebo cream in a 7 ?day wash off period. Record the fMRI data to document the local cerebral response after the erotic visual stimulation. Result: Among healthy women, the activation effects of the alprostadil cream were stronger than placebo in the left superior frontal gyrus and the right anterior frontal lobe, but weaker in the bilateral parietal lobe. For the FSAD patients, the activation effect of the alprostadil cream was weaker in the right parietal lobe. Alprostadil cream administration caused stronger activation in the right prefrontal lobe, left gyrus

  5. [Post-marketing clinical safety assessment of Shenmai injection based on active monitoring and passive monitoring in large data background].

    Science.gov (United States)

    Wang, Lian-xin; Xie, Yan-ming; Ai, Qing-hua; Song, Nian-bin

    2015-12-01

    This paper adopted a series of related analysis methods to comprehensively analyze post-marketing clinical safety data of Shenmai injection from 4,220 cases of SRS and 32,358 cases of multicenter, prospective, registered hospital centralized monitoring in large data background, calculated ADR incidence rate was 0.93 per 1,000, main symptoms of ADR includes chest pain, chills, skin itching, palpitations, fever, nausea, dizziness, vomiting, flushing, numbness, allergic reaction, cyanosis, rash, low back pain, and "breath", "anaphylactoid reaction" and "flush" were the safety warning signals of Shenmai injection. Primary disease for chronic pulmonary heart disease, thyroid disease, and combined with cerebral vascular disease, prior to the injection and continuous use of alprostadil, cyclic adenosine monophosphate, combined with quinolones, penicillins were suspicious influence factors of ADR of Shenmai injection, these promot the clinical safety. PMID:27245017

  6. Advances in the treatment of erectile dysfunction: what’s new and upcoming? [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Chintan K. Patel

    2016-03-01

    Full Text Available Erectile dysfunction adversely affects up to 20% of all men and is the most commonly treated sexual disorder. The public health implications of this condition are significant and represent a challenge for our healthcare system. The physiological pathways responsible for erections have been extensively studied, and much advancement has been made since the introduction of phosphodiesterase 5 inhibitors. Newer agents, such as dopaminergic and melanocortin receptor agonists, which target central erectogenic pathways, are under investigation. Newer formulations and delivery methods of existing medications such as alprostadil will also be introduced in the near future. Furthermore, low-intensity shockwave lithotripsy and stem cell regenerative techniques are innovative approaches to the treatment of erectile dysfunction.

  7. Cutaneous polyarteritis nodosa presented with digital gangrene: a case report.

    Science.gov (United States)

    Choi, Seung Won; Lew, Sogu; Cho, Sung Do; Cha, Hee Jeong; Eum, Eun A; Jung, Hyun Chul; Park, Jae Hoo

    2006-04-01

    Cutaneous polyarteritis nodosa (CPAN) is an uncommon form of vasculitis involving small and medium sized arteries of unknown etiology. The disease can be differentiated from polyarteritis nodosa by its limitation to the skin and lack of progression to visceral involvement. The characteristic manifestations are subcutaneous nodule, livedo reticularis, and ulceration, mostly localized on the lower extremity. Arthralgia, myalgia, peripheral neuropathy, and constitutional symptoms such as fever and malaise may also be present. We describe a 34-yr-old woman presented with severe ischemic change of the fingertip and subcutaneous nodules without systemic manifestations as an unusual initial manifestation of CPAN. Therapy with corticosteroid and alprostadil induce a moderate improvement of skin lesions. However, necrosis of the finger got worse and the finger was amputated. PMID:16614534

  8. Effect of sequential therapy of prostaglandins on renal function indexes in blood and urine specimens in patients with diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    Guo-Zhao Zhang; Zhi-Yuan Lu; Zhen Ren; Wei Wang

    2016-01-01

    Objective:To study the effect of sequential therapy of prostaglandins on renal function indexes in blood and urine specimens in patients with diabetic nephropathy.Methods: A total of 96 cases of patients with diabetic nephropathy (IV) were selected as the subjects of the study and randomly divided into control group (group A), alprostadil group (group B), beraprost sodium group (group C) and sequential therapy group (group D), renal color Doppler ultrasound was carried out, and trace albumin, total protein, 6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B2(TXB2) levels in 24 h urine specimens as well as creatinine (Cr), blood urea nitrogen (BUN), 6-keto-PGF1α, TXB2, cystatin C (CysC), retinol-binding protein (RBP) levels in blood specimens were determined.Results:Renal blood flow of group B, C and D were higher than that of group A and renal blood flow of group D was higher than those of group B and C; 24 h urine trace albumin, total protein and TXB2 levels as well as serum BUN, Cr, CysC and RBP levels of group B, C and D were significantly lower than those before treatment, and serum and urine 6-keto-PGF1α levels of group B, C and D were significantly higher than those before treatment; 24 h urine trace albumin, total protein and TXB2 levels as well as serum BUN, Cr, CysC and RBP levels of group D group were significantly lower than those of group B and group C, and serum and urine 6-keto-PGF1α levels of group D after treatment were significantly higher than those of group B and group C.Conclusion:Sequential therapy of alprostadil can protect renal function in patients with diabetic nephropathy, reduce proteinuria, improve glomerular filtration function and microcirculation disturbance, and inhibit platelet activation.

  9. Effects of infrared/red light therapy combined with nursing intervention on treatment of diabetic lower extremity arterial disease%红外/红光治疗仪联合护理干预对治疗糖尿病下肢血管病变疗效的影响

    Institute of Scientific and Technical Information of China (English)

    张颖; 赵小兰; 成雪兰; 陈燕梅

    2015-01-01

    目的::探讨红外/红光治疗仪联合前列地尔及护理干预治疗糖尿病下肢血管病变的临床疗效。方法:将60例糖尿病下肢血管病变患者随机分为对照组和治疗组两组,每组各30例。对照组给予前列地尔治疗,治疗组在对照组的基础上联合红外/红光治疗仪及护理干预治疗,均以14d 为1个疗程,比较两组治疗前后临床症状、足背动脉血流量、踝肱指数(ABI)的变化。结果:治疗组的总有效率显著高于对照组(P<0.01);治疗组足背动脉血流量、踝肱指数(ABI)均明显优于对照组(P<0.01)。结论:红外/红光治疗仪联合前列地尔及护理干预治疗糖尿病下肢血管病变疗效确切,值得推广。%Objective:To investigate the clinical efficacy of red light therapy combined with Qianlie infrared / and nursing intervention in the treatment of diabetic lower extremity vascular disease. Methods:60 patients of diabetic lower extremity vascular disease were randomly divided into treatment group and control group two groups, 30 patients in each group. The control groupreceived alprostadil treatment, the treatment group in the control group based on the combined infrared / red light therapy instrument and nursingintervention were in 14d for 1 courses, compared two groups before and aftertreatment of clinical symptoms, the volume of dorsal artery of foot and ankle brachial index (ABI) changes. Results the total effective rate in treatment groupwas significantly higher than that in control group (P< 0. 01); the treatment group the volume of dorsal artery of foot and ankle brachial index (ABI) was significant﹣ly better than the control group (P< 0. 01). Conclusion infrared / red light therapy combined with alprostadil in the treatment of diabetic lower extremity vascular disease can play their respective advantages, play asynergistic effect, and the nursing intervention can effectively improve the therapeutic effect and compliance.

  10. EFFECTS OF PROSTAGLANDIN E1 ON THE PROGRESSION OF ARISTOLOCHIC ACID NEPHROPATHY

    Institute of Scientific and Technical Information of China (English)

    Dong Sun; Jiang-min Feng; Yan-ling Zhao; Tao Jin; Li-ning Wang

    2005-01-01

    Objective To investigate the effects of prostaglandin El (PGE1) on the progression of aristolochic acid nephropathy AAN).Methods Twenty-four patients diagnosed as AAN with serum creatinine (Scr) between 1.5 mg/dL and 4 mg/dL during September 2001 to August 2003 were randomly divided into 2 groups. All patients had ingested long dan xie gan wan containing aristolochic acid (0.219 mg/g) for at least 3 months. Twelve patients were injected with Alprostadil (10 μg/d for 10days in one month, summing up to 6 months). Except for PGE1, the other therapy was same in both groups. Renal function was assessed using reciprocal serum creatinine levels (1/Scr).Results The level of Scr and serum hemoglobin (Hgb) was similar in both groups prior to therapy. During follow-up,1/Scr levels in PGE1 group were significantly higher than control group (P < 0.01), and Hgb levels in PGE1 group were significantly increased compared with control (P < 0.05).Conclusion PGE1 can slow the progression of renal failure and increase Hgb level of AAN patient.

  11. An Observational Study to Evaluate the Prevalence of Erectile Dysfunction (ED) and Prescribing Pattern of Drugs in Patients with ED Visiting an Andrology Specialty Clinic, Mumbai: 2012-14

    Science.gov (United States)

    Kulkarni, Vijay R.; Bhagat, Sagar B.; Beldar, Amit S.; Patel, Sadiq B.

    2015-01-01

    Introduction: Erectile dysfunction (ED) is a common occurrence and its incidence is expected to increase significantly along with the increase in various lifestyle diseases. The drug utilization for ED is very low. Also, studies describing the prescription pattern in ED are lacking. Materials and Methods: We conducted a retrospective cross-sectional observational study, including a drug utilization analysis, of 606 prescriptions as per the standard guidelines (WHO and STROBE). Results: Out of 606, 249 (41%) were from the age group of 30-39 years. Addictions were present in 388 (64%). Out of 606, 186 had urological, 154 had cardiovascular and 102 had psychological co-morbid disorders. Out of 348, 201 were prescribed Tadalafil (low dose) on a once daily basis. Out of 172, 121 were prescribed Sildenafil (high dose) on an ‘as and when required’ basis. Nutritional/ herbal supplements were prescribed in 126/606. The ratio of ‘Prescribed Daily Dose’ to ‘Defined Daily Dose’ of Tadalafil, Sildenafil, and Dapoxetine were 1.1, 1.3 and 1.5 respectively. Conclusion: Measures for de-addiction play an important role in the overall management of ED. The most common co-morbid disorders were urological, like BPH, LUTS, etc, followed by cardiovascular, psychological and diabetes. Overall, rational pharmacotherapy was observed. Tadalafil was the most commonly prescribed drug for ED. The main factor in the selection of a particular PDE5 inhibitor was its pharmacokinetics and cost. Udenafil, being the costliest, was the least prescribed. Dapoxetine was used in a significant number of individuals primarily for PE with ED. The combination of Papaverine, Chlorpromazine ± Alprostadil was used as intracavernosal injection in patients not responding to oral drugs. PMID:26393163

  12. Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions

    Directory of Open Access Journals (Sweden)

    Kengo Suzuki

    2013-11-01

    Full Text Available Prostaglandin E1 (PGE1, known pharmaceutically as alprostadil, has vasodilatory properties and is used widely in various clinical settings. In addition to acute vasodilatory properties, PGE1 may exert beneficial effects by altering protein expression of vascular cells. PGE1 is reported to be a potent stimulator of angiogenesis via upregulation of VEGF expression, which is under the control of the transcription factor hypoxia-inducible factor 1 (HIF-1. However, the molecular mechanisms behind the phenomenon are largely unknown. In the present study, we investigated the mechanism by which PGE1 induces HIF-1 activation and VEGF gene expression in human aortic smooth muscle cells (HASMCs and human umbilical vein endothelial cells (HUVECs, both vascular-derived cells. HUVECs and HASMCs were treated with PGE1 at clinically relevant concentrations under 20% O2 conditions and HIF-1 protein expression was investigated. Expression of HIF- 1α protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions. Studies using EP-receptor-specific agonists and antagonists revealed that EP1 and EP3 are critical to PGE1-induced HIF-1 activation. In vitro vascular permeability assays using HUVECs indicated that PGE1 increased vascular permeability in HUVECs. Thus, we demonstrate that PGE1 induces HIF- 1α protein expression and HIF-1 activation under non-hypoxic conditions and also provide evidence that the activity of multiple signal transduction pathways downstream of EP1 and EP3 receptors is required for HIF-1 activation.

  13. Treatment for pulmonary artery hypertension in liver tranaplantation%肝移植过程中肺动脉高压的处理

    Institute of Scientific and Technical Information of China (English)

    罗远国; 胡春林; 李洪

    2008-01-01

    selective for the liver transplantation. METHODS: Undergoing general anesthesia, mean arterial blood pressure, central venous pressure, pulmonary arterial pressure and pulmonary arterial wedge pressure were continuously monitored by Swan-Ganz catheter method and reversible Fick's law continuous monitoring. Available respiration administration, low dose of glyceryltrinitrate (0.1-5.0 u g/kg/min) and Alprostadil (1.0-2.0 u g) were administered to diminish elevated pulmonary arterial pressure and pulmonary arterial wedge pressure during the period after unclamping portal vein in liver transplantation. MAIN OUTCOME MEASURES: Changes of mean arterial blood pressure and pulmonary arterial pressure. RESULTS: The mean arterial blood pressure deceased at the time of unclamping portal vein in all 13 patients, pulmonary arterial pressure and pulmonary arterial wedge pressure both increased significantly at 5 and 15 minutes within neo-hepatic stage, which were more obvious than those during anhepatic stage in 13 patients(P<0.05).The pulmonary arterial pressure and pulmonary arterial wedge pressure revived to the level before unclamping inferior vein by treatment with glyceryltrinitrate and Alprostadil within 30 minutes. CONCLUSION: Reasonable application of glyceryltrinitrate and Alprostadil can obviously release pulmonary arterial pressure during neo-hepatic stage in liver transplantation.

  14. Using a Cobalt Amine United Front, For the Treatment of Diabetic Periph-eral Neuropathy Clinical Observations and Curative Effect Analysis%运用甲钴胺联合前列地尔治疗糖尿病周围神经病变的临床观察与疗效分析

    Institute of Scientific and Technical Information of China (English)

    王毓

    2015-01-01

    Objective To observe diabetic peripheral neuropathy (diabetic peripheral neuropathy, DPN) clinical treatment methods to explore the use of Mecobalamin alprostadil therapy of diabetic peripheral neuropathy. Methods 60 patients ad-mitted to our hospital with diabetic peripheral neuropathy patients, based on length of stay were randomly divided into con-trol and experimental groups of 30 patients in the control group using only mecobalamin treatment. The experimental group Mecobalamin alprostadil treatment, the difference between the two groups after treatment. Results After treatment, patients in the experimental group effective rate was 92.3%, the effective rate was 71.3% in the control group, the experimental group was significantly higher, the difference was statistically significant(P<0.05), using Mecobalamin alprostadil treatment of diabetes peripheral neuropathy has a significant effect, high safety factor, significantly reduced adverse reactions, which can effectively improve and enhance the quality of life in patients with diabetic peripheral neuropathy. Conclusion Through clinical research, the use of a united front to cobalt amine in the process of the treatment of diabetic peripheral neuropathy, after two drugs used in combination, the two drugs synergy in the body to achieve the improvement and restore the function of diabetic peripheral neuropathy. Compared with single application of a form of drug treatment, remarkable curative effect, high safety coefficient, less adverse reaction, for the clinical treatment of diabetic peripheral neuropathy disease provided the powerful basis.%目的:通过观察糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床治疗方法,探讨运用甲钴胺联合前列地尔治疗糖尿病周围神经病变的疗效。方法选择该院收治的60例糖尿病周围神经病变患者,根据住院时间随机分为对照组和实验组,每组30例,对照组仅使用甲钴胺进行治疗。实验组

  15. Clinical study of Salvia miltiorrhiza injection in patients with systemic sclerosis%注射用丹参治疗局限型系统性硬化病的临床疗效及其作用机制

    Institute of Scientific and Technical Information of China (English)

    高戈; 王欣; 田静; 杜金峰; 谢希; 高洁生

    2012-01-01

    目的 探讨注射用丹参静脉滴注治疗系统性硬化病的临床疗效和作用机制.方法 46例系统性硬化病患者分成2组:治疗组予丹参冻干粉针0.8 g,iv,gtt,qod,口服青霉胺0.375 g,qd,沙利度胺100 mg,qd,积雪苷72 mg,qd,泼尼松10 mg,qd;对照组予前列地尔100 μg,iv,gtt,qod,其他治疗同治疗组,连续治疗3 mo,比较2组患者治疗前后皮肤损害的Rodnan修定评分、Furst's内脏评分、全血黏度、血浆黏度、相对黏度、聚集指数、过氧化脂质(LPO)、超氧化物岐化酶(SOD)的变化以判断疗效及作用机制.结果 治疗组皮肤损害的R0dnan修定评分、Furst's内脏评分(3.5±2.2、4.8±6.4)显著低于对照组(6.8±6.3、6.7±3.8) (P<0.01,0.05).治疗组血液流变学指标显著改善,优于对照组(P< 0.01,0.05);LPO明显降低,SOD明显上升与对照组比较有显著差异(P<0.01).结论 丹参冻干粉针能显著改善皮肤损害和减轻内脏受累,其作用机制可能与血液流变学的显著改善、LPO降低、SOD上升有关.%AIM To study the curative effects and probable mechanisms of Salvia miltiorrhiza injection in patients with systemic sclerosis. METHODS A total of 46 systemic sclerosis patients were randomized into two groups. All patients were orally administered with bellacilline 0.375 g-d-1, thalidomide 100 mg^d-1, madecasso-side 72 mg-d-1 and prednisone 10 mg-d-1. The patients in the treatment group and the control group were respectively treated with Salvia miltiorrhiza injection (0.8 g, iv, gtt, qod) and alprostadil (100 μg, iv, gtt, qod) for 3 months. Modified Rodnan skin score and Furst's internal organs score were determined, and whole blood viscosity, blood plasma viscosity, relative viscosity, aggregation index, LPO and SOD were tested. RESULTS Modified Rodnan skin score and Furst' s internal organs score in the treatment group (3.5 ± 2.2,4.8 ± 6.4) were lower than those in the control group (6.8 ± 6.3, 6.7 ± 3.8) (P < 0.01, 0

  16. AB028. Current status of pharmacotherapy for erectile dysfunction

    Science.gov (United States)

    Adaikan, P Ganesan

    2016-01-01

    The advent of phosphodiesterase type 5 (PDE5) inhibition as oral therapy has significantly revolutionized both clinical and basic research in the area of erectile dysfunction (ED). Much of this progress is due to a better understanding in the last three decades of the various pathophysiological and cellular mechanisms contributing to ED. Apart from the three available PDE5 inhibitors viz., sildenafil, tadalafil and vardenafil globally at the turn of this century, four other PDE inhibitors have joined the armament in recent time; these include avanafil, lodenafil, mirodenafil and udenafil. All seven PDE inhibitors are effective therapies for the treatment of ED in men. There is no significant difference among them with respect to efficacy, safety profile and tolerability. As such, good safety profiles have widened the horizon in patient choice, selectivity and efficacy. With the ease of oral administration and better patient compliance, other measures of the past, including intracavernosal injections and non-pharmacological treatments have been relegated to second-line therapy for most patients with ED. But, PDE inhibitors as first-line oral therapies are effective in about 75% of male patients diagnosed with ED. Intracavernous injection (IC) therapy with PGE1 (alprostadil) for about 10% patient-usage in general is a well-known effective and well tolerated treatment for men with ED. It is also recommended as a second line therapy for ED along with urethral and topical PGE1. Transurethral PGE1 is less effective compared to IC PGE1. Also the transurethral dosage options are 125 to 1,000 µg, while the IC dosage options are 5 to 40 µg. The topical PGE1 (300 µg in 100 mg of the cream) is also less effective compared to IC PGE1. Topical cream is not approved in many countries as yet. Other existing vasoactive agents such as papaverine, and alpha adrenergic blockers and their combinations and the ever increasing number of other agents in the pipeline including nitric

  17. 不同手术时机对危重肺动脉瓣狭窄球囊扩张术疗效的影响研究%Perinatal integrative intervention for critical pulmonary artery valve stenosis

    Institute of Scientific and Technical Information of China (English)

    周开宇; 华益民; 王一斌; 朱琦; 母得志; 唐军; 周容; 王川; 李一飞

    2013-01-01

    Objective To investigate the effect of different operation time to percutaneous balloon pulmonic valvuloplasty (PBPV) to critical pulmonary valve stenosis (CPS).Method Twenty-one infants (age ≤60 days at operating day) suffered from CPS,diagnosed by fetal echocardiogram and confirmed by echocardiography after birth,were enrolled in this case-control-study with written informed consent during April 2007 to December 2011.Of the 21 cases,7 had prenatal diagnosis in our prenatal diagnosis center (prenatal group,Pre) and 14 were referred from other hospitals,who were divided into postpartum group A (Post A,referred within 28 days after birth) and postpartum group B (Post B,referred 29 to 60 days after birth).To Pre-group,the integrative interventional protocol was cautiously made by the consultative specialists,including intrauterine diagnosis,perinatal care and urgent PBPV soon after birth.To Postgroup,emergency PBPV was preformed after the referral.Tei index of right ventricular and pressure-gradient (PG) between right ventricular and pulmonary artery were measured before and at different time points one year after PBPV.Result The values of SpO2 in Pre-group ranged from 82%-92% (86.57% + 5.34%)under the state of continuous intravenous infusion of alprostadil.PBPV was successfully preformed within 3-6 days after birth.The values of SpO2 increased to 97.33% + 1.15% post procedure.The values of PG preand post-procedure were (86.34 + 11.77) mm Hg and (31.43 + 8.46) mm Hg respectively.Preoperative RV Tei-index was 0.68 + 0.05,it decreased rapidly after procedure,and recovered to normal one month after procedure.Only one case showed restenosis seven months after procedure and repeated PBPV.Fourteen referral cases (6 cases in Post A group and 8 cases in Post B group,accompanied in 1 and 3 cases with heart failure),the values of SpO2 ranged from 83%-91% under state of continuous intravenous infusion of alprostadil.And the operating time was 10-57 days after

  18. A Randomized Clinical study of Domestic Clopidogrel Lipoic acid and Cilostazol in Treatment of Peripheral Arterial Occlusive Disease%硫酸氢氯吡格雷治疗糖尿病下肢动脉闭塞症的随机对照临床试验研究

    Institute of Scientific and Technical Information of China (English)

    李林; 何永城; 李旭盛; 李群

    2015-01-01

    目的:观察硫酸氢氯吡格雷治疗2型糖尿病( T2DM)下肢动脉闭塞( PAD)的有效及安全性。方法:入选94例糖尿病性PAD患者,按照随机数列表分为对照组48例,住院期间给予前列地尔、甲钴胺、羟基红花素注射液、西洛他唑联合治疗7~14天,出院后单独给予西洛他唑口服12周。治疗组在对照组基础上住院或出院均给予首次600mg,后150mg/d连续7天,后改为75mg/d连续8周。评价氯吡格雷治疗DM所致的PAD的临床效果、血流动力学及下肢溃疡坏死率。结果:治疗组显效率(75.0%vs 54.3%, P=0.036)、总有效率(95.8%vs 80.4%, P=0.020)均显著高于对照组,治疗组6个月内再次发生溃疡坏疽发生率为2.0%,对照组为13.0%,2组发生率具有统计学差异(P<0.05)。另外治疗组ABI改善程度(0.94±0.23 vs 0.72±0.31)、足背动脉血流速度(38.2±3.9 vs 33.5±2.8),腘动脉血流速度(68.2±8.9 vs 56.8±5.8)改善均优于对照组,2组血小板聚集率分别为(27.3±14.8%vs 38.4±12.6%),2组比较具有统计学差异(P<0.05)。治疗过程中,2组发生的不良反应无明显的统计学差异(P>0.05)。结论:氯吡格雷治疗DM所致的PAD具有一定的疗效,可用于预防下肢溃疡发生率。%Objective:To evaluate clopidogrel bisulfate cilostazol treatment of lower extremity arterial occlusive disease ( PAD) is ef-fective and safe sex .Methods:84 cases were randomly selected transluminal angioplasty or vascular reconstructive surgery is not the line of lower extremity arterial occlusive disease patients, all patients were treated conservatively , given lipoic acid mecobalamin + + +Danhong alprostadil injection , are intravenous administration, while the control group given cilostazol , clopidogrel therapy in the treat-ment group were given on the basis of the

  19. 30例完全性肺静脉异位引流患儿术后早期并发症分析及处理对策%The early postoperation complications and treatments in 30 children with total anomalous pulmonary venous connection

    Institute of Scientific and Technical Information of China (English)

    付红敏; 刘成军; 谭利平

    2012-01-01

    目的 了解完全性肺静脉异位引流(total anomalous pulmonary venous connection,TAPVC)术后早期发生的并发症,总结处理对策.方法 收集行TAPVC根治术后转入PICU监护的患儿30例,术后常规心电、血压、血氧饱和度监护,呼吸机辅助呼吸,并经镇静、止血、正性肌力药物治疗、利尿、扩血管、抗感染及对症等综合处理.有低心排血量表现时再加用肾上腺素或异丙肾上腺素.出现缓慢性心律失常时,予临时起搏器治疗.患儿术前即有重度肺动脉高压或术后判断有反应性肺动脉高压时予前列地尔或西地那非.结果 30例患儿术后并发肺炎13例(43.3%),心律失常8例(26.7%),低心排血量综合征7例(23.3%),呼吸衰竭6例(20.0%),肺动脉高压4例(13.3%),肺水肿及肺不张各3例(10.0%),肺出血1例(3.3%).术后早期死亡2例.ICU住院时间l~21 d[(5.95±4.94)d].结论 TAPVC术后早期呼吸系统的并发症发生率最高,因此,防治肺部感染、维护肺功能应作为术后早期监测和处理的重点,同时注意纠正心律失常,防治低心排血量和肺动脉高压危象,以提高TAPVC患儿术后的成活率与监护质量.%Objective To summarize the early postoperation complications and treatments in children with total anomalous pulmonary venous connection (TAPVC).Methods Thirty TAPVC children who were treated with corrective operation and transferred into PICU were collected.Patients were monitored routinely for electrocardiogram,blood pressure and SpO2.The routine treatment measures included mechanical ventilation,sedation,hemostasis,positive inotropic agents,diuresis,vasodilator,antibiotics and symptomatic treatment.Adrenaline or isoproterenol was used when low cardiac output syndrome appeared and temporary pacemaker was employed in the case of bradycardia.Alprostadil and sildenafil were added instantly after corrective operation when severe preoperative pulmonary hypertension or reactive

  20. Analysis on the therapeutic effective rate of hyperbaric oxygen in the treatment of full-frequency loss in the patients with sudden deafness%高压氧综合治疗全频听力损失突发性耳聋患者的临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    杨晶; 武连华; 刘雪华; 梁芳; 孙波; 高春锦; 王国忠

    2013-01-01

    Objective To observe the dynamic characteristics of hearing recovery in full-frequency hearing loss in the patients with sudden deafness following HBO therapy.Methods Eighty-two cases of fullfrequency hearing loss confirmed by ENT specialists were randomly divided into the control group (40 cases)and the HBO therapy group (42 cases).The patients in the control group were given routine treatment,i.e.10mg of dexamethasone intravenous infusion for first 3 days,then,5 mg of dexamethasone for another 3 days.Besides,the patients were administered 10 μg alprostadil intravenous infusion,once a day for 14 consecutive days; 100 mg of Vitamin B1,500 μg of B12 muscular injection,once day for 30 consecutive days.The patients in the HBO therapy group were given HBO therapy + routine treatment,once a day,10 sessions a treatment course.Following 2 or 4 consecutive treatment courses,pure tone audiometry was performed.Results After 2 courses of HBO therapy,low-frequency average hearing level [(38.16 ± 5.88) dB] increased for the patients in the HBO therapy group,when compared with that of the patients in the control group[(24.68 ± 3.87) dB],with statistical significance (P < 0.01).On the other hand,high-frequency average hearing level [(12.33 ± 2.98) dB] increased to some extent for the patients in the HBO therapy group,when compared with that of the patients in the control group [(10.49 ± 2.34) dB],without statistical significance(P > 0.05).For most patients,low-frequency hearing level improved more markedly and recovered more quickly.Total effective rate (80.9%) for the HBO group increased,when compared with that of the control group (62.5%),but without statistical significance (P > 0.05).When compared with low-frequency hearing level,high-frequency hearing level recovered more slowly.At the end of the 4 courses,pure tone monitoring indicated that improvement was seen mainly in high-frequency hearing level.For the patients in the HBO therapy group

  1. ABO血型不合肝移植治疗急危重症肝病患者的临床疗效分析%Analysis of the curative effect of ABO-incompatible liver transplantation in the treatment in patients with acute severe liver disease

    Institute of Scientific and Technical Information of China (English)

    沈中阳; 邓永林; 郑虹; 潘澄; 张雅敏; 蒋文涛; 张建军; 高伟; 淮明生

    2014-01-01

    Objective To analyze and evaluate the clinical effect of ABO-incompatible liver transplantation in the treatment of acute severe liver disease.Methods A retrospective clinical study was conducted.The clinical data of 4 136 patients undergoing orthotopic liver transplantation in Organ Transplantation Center of Tianjin First Center Hospital from September 1999 to December 2013 were analyzed.The criteria of patients enrolled were as following:model for end-stage liver disease (MELD) score ≥ 20,the donor's and recipient's blood types were different,age 18-70 years,and undergone primary non-bypass orthotopic liver transplantation.According to the rate of compliance with the principles of blood transfusion,the cases were divided into two groups:ABO-compatible group (ABO-C group,n =41),ABO-incompatible group (ABO-I group,n =22).The patients in ABO-I group received basiliximab + methylprednisolone for immune induction therapy during operation,basiliximab + tacrolimus + mycophenolate + cortisol as quadruple immunosuppressive regimen after operation.They also received subcutaneous injection of low molecular heparin for anticoagulant therapy after operation,and oral warfarin or aspirin and clopidogrel bisulfate instead after 7 days.They also received routine alprostadil after operation.The remaining treatment was the same as that of ABO-C group.The clinical data,postoperative complications,rejection and survival rates of two groups were statistically analyzed.Results There were no significant differences in gender,age,MELD score,complicated with tumor,quality of donor liver,length of cold preservation of donor liver,duration of operation,and blood loss during operation between ABO-C and ABO-I groups.Number of splenectomy during operation was significantly higher in ABO-I group than that in ABO-C group (5 cases vs.1 case,x2=4.687,P=0.030).The 3-month,6-month,1-year,3-year and 5-year survival rates of ABO-C group were 89.5%,78.3%,72.5%,69.1% and 61.8