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Sample records for allikmets eda tammelo

  1. Ellu jääda ja edasi minna. [1.-5. osa] / Ilmar Tammelo ; tõlkinud Ilmar Anvelt

    Index Scriptorium Estoniae

    Tammelo, Ilmar, 1917-1982

    1990-01-01

    Õigluse mõiste, materiaalne õiglus ja negatiivne, positiivne ja neutraalne olemine. Inimsuhtluse mõiste, inimene, seadus ja kommunikatsioon ning kommunikatsiooni kohustus. Poliitiline võim ja maailmakord. Lisad: Järvelaid, Peeter. Ilmar Tammelo (1917-1982) / nr. 10, lk. 2219-2231 ; Ilmar Tammelo teoste bibliograafia / koost. Jaan Isotamm, nr. 10, lk. 2232-2240

  2. ITER EDA and technology

    International Nuclear Information System (INIS)

    Baker, C.C.

    2001-01-01

    The year 1998 was the culmination of the six-year Engineering Design Activities (EDA) of the International Thermonuclear Experimental Reactor (ITER) Project. The EDA results in design and validating technology R and D, plus the associated effort in voluntary physics research, is a significant achievement and major milestone in the history of magnetic fusion energy development. Consequently, the ITER EDA was a major theme at this Conference, contributing almost 40 papers

  3. ITER EDA newsletter. V. 10, special issue

    International Nuclear Information System (INIS)

    2001-07-01

    This ITER EDA Newsletter includes summaries of the reports of ITER EDA JCT Physics unit about ITER physics R and D during the Engineering Design Activities (EDA), ITER EDA JCT Naka JWC ITER technology R and D during the EDA, and Safety, Environment and Health group of ITER EDA JCT, Garching JWS on EDA activities related to safety

  4. ITER EDA technical activities

    International Nuclear Information System (INIS)

    Aymar, R.

    1998-01-01

    Six years of technical work under the ITER EDA Agreement have resulted in a design which constitutes a complete description of the ITER device and of its auxiliary systems and facilities. The ITER Council commented that the Final Design Report provides the first comprehensive design of a fusion reactor based on well established physics and technology

  5. EDA activities related to safety

    International Nuclear Information System (INIS)

    Gordon, C.; Raeder, J.

    2001-01-01

    This article reviews the accomplishments in ITER safety analysis during the course of the Engineering Design Activities (EDA). The key aspects of ITER safety analysis are: effluents and emissions from normal operation, including planned maintenance activities; occupational safety for workers at the facility; radioactive materials and wastes generated during operation and from decommissioning ; potential incidents and accidents and the resulting transients. As a result of the work during the EDA it is concluded that ITER is safe

  6. ITER EDA status

    International Nuclear Information System (INIS)

    Aymar, R.

    2001-01-01

    '', each representing a potential real procurement contract for an ITER component. The results, after analysis and evaluation by the JCT, have provided the basis for a JCT ''evaluated cost estimates'' report for all packages (Business Confidential) which was presented during a one week meeting at Garching (29 Jan - 2 Feb 2001) to an Ad Hoc Group of Parties' costing experts. The summary was included in the synoptic paper of the PDD for the Council's information. A meeting of the ITER Test Blanket Working Group (TBWG) was held in October 2000. The group has continued its activities during the period of extension of the EDA with a revised charter on the co-ordination of the development work performed by the Parties and by the JCT leading to a co-ordinated test programme on ITER for a DEMO-relevant tritium breeding blanket. This follows earlier work carried out during the EDA, which formed part of the 1998 Final Design Report. For a concise summary of the meeting see the separate article on the Test Blanket Working Group's Recent Activities in the ITER EDA Newsletter, Vol. 10, No. 2, Feb. 2001

  7. Relevant documents initiating the EDA

    International Nuclear Information System (INIS)

    1993-01-01

    In December 1990, the four ITER Parties successfully concluded the Conceptual Design Activities for ITER. In January, 1991, each of the Parties had decided to enter negotiations on co-operation in the ITER EDA, which are to be conducted under the auspices of the IAEA; and each Party was prepared to receive a letter of invitation from the Director General of the IAEA to participate in those negotiations. Four negotiating meetings were held in 1991, the first being in Vienna, the second in Tokyo, the third in Reston near Washington, and the fourth in Moscow. After completion of the negotiations, each of the Parties proceeded domestically to reach its decision to sign the ITER EDA Agreement and its Protocol 1. All formalities were concluded during the first half of 1992, and the EDA documents were signed in Washington on July 21, 1992. Following the signing, each of the Parties provided the Director General with the names of its two ITER Council members. With the formation of the Council, the EDA had begun. This volume contains the papers developed before the start of the EDA. It begins with the Director General's invitation to participate in the negotiations and ends with the Parties' designations of the ITER Council members. While the evolving text of the Agreement and its Protocol 1 is referred to in some of these papers as an attachment, it is only the final, signed text that is reproduced in this volume

  8. ITER EDA newsletter. V. 2, no. 11

    International Nuclear Information System (INIS)

    1993-11-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains an ITER EDA Status Report, and a report on the Fourth International Fusion Neutronics Workshop at the University of California, Los Angeles Campus, October 20-21, 1993

  9. ITER EDA Newsletter. V.3, no.3

    International Nuclear Information System (INIS)

    1994-03-01

    This ITER EDA Newsletter issue contains reports on (i) the completion of the ITER EDA Protocol 1, (ii) the signing of ITER EDA Protocol 2, (iii) a technical meeting on pumping and fuelling and (iv) a technical meeting on the ITER Tritium Plant

  10. Status of the ITER EDA

    International Nuclear Information System (INIS)

    Aymar, R.

    2000-01-01

    This article summarizes progress made in the ITER Engineering Design Activities in the period between the ITER Meeting in Tokyo (January 2000) and June 2000. Topics: Termination of EDA, Joint Central Team and Support, Task Assignments, ITER Physics, Urgent and High Priority Physics Research Areas

  11. ITER EDA Newsletter. V. 10, no. 7

    International Nuclear Information System (INIS)

    2001-07-01

    This ITER EDA Newsletter presents an overview of meetings held at IAEA Headquarters in Vienna during the week 16-20 July 2001 related to the successful completion of the ITER Engineering Design Activities (EDA). Among them were the final meeting of the ITER Council, the closing ceremony to commemorate the EDA completion, the final meeting of the ITER Management Advisory Committee, a briefing of issues related to ITER developments, and discussions on the possible joint implementation of ITER

  12. ITER EDA Newsletter. V. 2, no. 1

    International Nuclear Information System (INIS)

    1993-01-01

    This ITER EDA (Engineering Design Activities) Newsletter issue is dedicated to the description of the ITER EDA Home Teams (European Community, Japan, Russian Federation, USA), in particular their composition, tasks, responsibilities, national support and activities, aimed to design the ITER tokamak

  13. ITER EDA Newsletter. Vol. 1, No. 1

    International Nuclear Information System (INIS)

    1992-11-01

    After the ITER Engineering Design Activities (EDA) Agreement and Protocol 1 had been signed by the four ITER parties on July 21, 1992 and had entered into force, the ITER Council suggested at its first meeting (Vienna, September 10-11, 1992) that the publication of the ITER Newsletter be continued during the EDA with assistance of the International Atomic Energy Agency. This suggestion was supported by the Agency and subsequently the ITER office in Vienna assumed its responsibilities for planning and executing activities related to the publication of the Newsletter. The ITER EDA Newsletter is planned to be a monthly publication aimed at disseminating broad information and understanding, including the description of the personal and institutional involvements in the ITER project in addition to technical facts about it. The responsibility for the Newsletter rests with the ITER council. In this first issue the signing of the ITER EDA Activities and Protocol 1 is reported. The EDA organizational structure is described. This issue also reports on the first ITER EDA council meeting, the opening of the ITER EDA NAKA Co-Centre, the first meeting of the ITER Technical Advisory Committee, activities of special working groups, an ITER Technical Meeting, as well as ''News in Brief'' and ''Coming Events''

  14. ITER EDA newsletter. V. 5, no. 8

    International Nuclear Information System (INIS)

    1996-08-01

    This issue of the Newsletter on the Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on the divertor remote handling development (and of a summer party at the ITER Joint Work Site in Garching, Germany)

  15. ITER EDA newsletter. V. 5, no. 8

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    This issue of the Newsletter on the Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on the divertor remote handling development (and of a summer party at the ITER Joint Work Site in Garching, Germany).

  16. ITER EDA newsletter. V. 7, no. 7

    International Nuclear Information System (INIS)

    1998-07-01

    This newsletter contains the articles: 'Extraordinary ITER council meeting', 'ITER EDA final safety meeting' and 'Summary report of the 3rd combined workshop of the ITER confinement and transport and ITER confinement database and modeling expert groups'

  17. Harnessing VLSI System Design with EDA Tools

    CERN Document Server

    Kamat, Rajanish K; Gaikwad, Pawan K; Guhilot, Hansraj

    2012-01-01

    This book explores various dimensions of EDA technologies for achieving different goals in VLSI system design. Although the scope of EDA is very broad and comprises diversified hardware and software tools to accomplish different phases of VLSI system design, such as design, layout, simulation, testability, prototyping and implementation, this book focuses only on demystifying the code, a.k.a. firmware development and its implementation with FPGAs. Since there are a variety of languages for system design, this book covers various issues related to VHDL, Verilog and System C synergized with EDA tools, using a variety of case studies such as testability, verification and power consumption. * Covers aspects of VHDL, Verilog and Handel C in one text; * Enables designers to judge the appropriateness of each EDA tool for relevant applications; * Omits discussion of design platforms and focuses on design case studies; * Uses design case studies from diversified application domains such as network on chip, hospital on...

  18. ITER EDA newsletter. V. 6, no. 3

    International Nuclear Information System (INIS)

    1997-03-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter reports on the Central Solenoid Model Coil Project (Function, Objectives, Design, Project Management, Testing, Work Organization and Status). 8 figs, 2 tabs

  19. ITER EDA Newsletter. V.3, no.4

    International Nuclear Information System (INIS)

    1994-04-01

    This ITER EDA Newsletter issue contains a report on the fifth meeting of the ITER Management Advisory Committee and a summary of a magnet and safety technical meeting held at Naka, February 22-25, 1994

  20. ITER EDA newsletter. V. 8, no. 8

    International Nuclear Information System (INIS)

    1999-08-01

    This ITER EDA newsletter reports on the programme directors meeting of 28-29 July 1999, the Snowmass Fusion Summer Study Group workshop and the ITER Management Advisory Committee meeting in Garching. Individual abstracts are prepared for the 3 meetings

  1. ITER EDA newsletter. V. 9, no. 2

    International Nuclear Information System (INIS)

    2000-02-01

    This ITER EDA Newsletter reports on the seventh ITER technical meeting on safety and environment and contains the executive summary of the eleventh ITER scrape-off layer and divertor physics expert group meeting. Individual abstracts have been prepared

  2. Parties working on continuation of ITER EDA

    International Nuclear Information System (INIS)

    Roberts, M.

    1998-01-01

    This article describes efforts of the 4 ITER partners, the European Atomic Energy Community and the governments of Japan, the Russian Federation and the USA, to agree to continuation of the ITER EDA. While the former 3 partners signed an Extension to the EDA, the Americans were refused funding by the US Congress und will therefore be phased out within one year. Copies of the documents signed are provided

  3. ITER EDA newsletter. V. 4, no.12

    International Nuclear Information System (INIS)

    1995-12-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains a report on the ninth ITER council meeting held December 12 - 13, 1995 in Garching near Munich, Germany (by Dr. E. Canobbio), a report on the status of the ITER EDA (by Dr. R. Aymar, ITER Director) and a report on the ninth meeting of the ITER Technical Advisory Committee (by Professor P. Rutherford, TAC Chair) held 27 - 29 November 1995, in Garching near Munich, Germany

  4. ITER EDA newsletter. V. 5, no. 7

    International Nuclear Information System (INIS)

    1996-07-01

    This issue of the Newsletter on the Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on the Tenth ITER Council Meeting, held July 24-25, 1996, in St. Petersburg, Russia; a description of the Status of the ITER EDA by the ITER Director, Dr. R. Aymar; and a report on the so-called Task Number One by the ITER Special Working Group (Basis for the Start of Explorations, presenting possible scenarios toward siting, licensing and host support)

  5. ITER EDA newsletter. V. 9, no. 8

    International Nuclear Information System (INIS)

    2000-08-01

    This ITER EDA Newsletter reports on the ITER meeting on 29-30 June 2000 in Moscow, summarizes the status report on the ITER EDA by R. Aymar, the ITER Director, and gives overviews of the expert group workshop on transport and internal barrier physics, confinement database and modelling and edge and pedestal physics, and the IEA workshop on transport barriers at edge and core. Individual abstracts have been prepared

  6. Testing The Enhanced Data Authentication System (EDAS)

    International Nuclear Information System (INIS)

    Thomas, M.; Baldwin, G.; Hymel, R.; Goncalves, J.G.M.; Dechamp, L.; ); Johnson, S.; Smejkal, A.; Linnebach, R.; Rue, M.

    2015-01-01

    The Enhanced Data Authentication System (EDAS) is a secure branching concept that provides a safeguards inspectorate a copy of measurement data from operator instrumentation. Both safeguards inspector and facility operator requirements for secure branching have been established in previous work. These dictated the design and development of EDAS hardware and software. This paper presents the test plan for the EDAS prototypes, which need to demonstrate performance against the identified requirements. Sandia National Laboratories (SNL), Directorate-General for Energy (DG-Energy) in Luxembourg, and the Joint Research Centre (JRC) in Ispra will each perform different tests on the EDAS prototypes. Sandia, the developer, will perform comprehensive testing of functionality, robustness, and reliability. The JRC, as an independent technical organization, will evaluate electrical safety and other environmental factors important to facility operator acceptance. The JRC is also able to simulate field trial conditions using equipment similar to what will be used in the field trial. DG-Energy will confirm the Sandia tests and also test the interface of the EDAS prototype to the RADAR data acquisition and analysis system used by the Euratom inspectorate. The EDAS prototypes will be tested in a comprehensive field trial at the Westinghouse Springfields facility in a collaboration between Euratom inspectors and the facility operator. The field trial will support barcode and weight measurements taken related to the movements of nuclear material items entering and exiting the facility. One EDAS prototype will branch barcode scanner data, while the other will branch facility weight scale data. The branched data will be sent securely to an inspector computer, accessible to a Euratom inspector for data analysis. The field trial will test operational factors and environmental conditions. A critical outcome will be to ascertain whether the inspectorate gains an accurate picture of the

  7. ITER EDA newsletter. V. 7, no. 9

    International Nuclear Information System (INIS)

    1998-09-01

    Newsletter containing the two articles 'Parties working on continuation of ITER EDA' and 'ITER exhibit at the Austria Centre, Vienna'. The first article describes efforts of the 4 ITER partners, the European Atomic Energy Community and the governments of Japan, the Russian Federation and the USA, to agree to continuation of the ITER EDA. While the former 3 partners signed an Extension to the EDA, the Americans were refused funding by the US Congress und will therefore be phased out within one year. Copies of the documents signed are provided. The second article reports on exhibition featuring a model of ITER and various other means of information on nuclear fusion which took place at the IAEA Headquarters from the 21st to 25th of September 1998. There is also an article in memoriam of Alexander V. Kashirski, who died on the 29th of September 1998

  8. ITER EDA Newsletter. V. 3, no. 10

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the ITER-relevant statements made at the occasion of the 15th IAEA fusion conference in Seville, Spain, September 26 - October 1, 1994; (ii) a comprehensive technical presentation of the ITER EDA developments at the same conference; (iii) the first Workshop of the ITER Expert Group on Confinement and Transport, held at the San Diego Joint Work Site on 22-25 August 1994; and (iv) the visit to the San Diego Work Site of the representatives of a local philanthropic group, the ARCS Foundation (Achievement Rewards for College Scientists).

  9. ITER EDA Newsletter. V. 3, no. 10

    International Nuclear Information System (INIS)

    1994-10-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the ITER-relevant statements made at the occasion of the 15th IAEA fusion conference in Seville, Spain, September 26 - October 1, 1994; (ii) a comprehensive technical presentation of the ITER EDA developments at the same conference; (iii) the first Workshop of the ITER Expert Group on Confinement and Transport, held at the San Diego Joint Work Site on 22-25 August 1994; and (iv) the visit to the San Diego Work Site of the representatives of a local philanthropic group, the ARCS Foundation (Achievement Rewards for College Scientists)

  10. ITER EDA newsletter. V. 6, no. 1

    International Nuclear Information System (INIS)

    1997-01-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter reports on the STATUS OF THE ITER EDA Overview, Design Work, ITER Physics; contains a report of the Third Technical Meeting on Quality Assurance was held at the ITER Garching Joint Work Site on 25-27 November 1996. The objectives of the meeting were to review the progress made in the Implementation of QA and to identify weal areas which require improvement. The focus was on the Large R and D Projects assigned to the EU Home Team(HT) or placed under the responsibility of the Garching JWS. 1 fig, 3 tabs

  11. Kiri Pariisist / Aire Allikmets

    Index Scriptorium Estoniae

    Allikmets, Aire

    1998-01-01

    1997-1999 toimuvast Jaapani aastast Prantsusmaal ja Prantsuse aastast Jaapanis. Prantsuse Rahvuslikus Keraamikamuuseumis keraamikanäitus "Cordes de feu", tuhat aastat jaapani keraamikat Bisenis, Nabeshima ülikute portselan. Keraamik Suzuki Osamu isikunäitus ja 170 jaapani kalligraafi tööd "Les Ma̋tres de l'encre" Espace des Arts Mitsukoshi-Etoile'is. Prantsuse aasta avaakord - Statue de la Liberté eksponeerimine Tokios. Tokio rahvusmuuseumis Delacroix' maal "Vabadus juhib rahvast barrikaadidele". Kavasolevaid prantsuse kunsti näitusi.

  12. ITER EDA newsletter. V. 9, no. 9

    International Nuclear Information System (INIS)

    2000-09-01

    This ITER EDA Newsletter contains the following 5 contributions: CSMC and CSIC charging tests successfully completed; The ITER divertor cassette project meeting; Blanket R and D and design task meeting; IAEA technical committee meeting on fusion safety; ITER L-6 large project ''blanket remote handling and maintenance''

  13. ITER EDA Newsletter. V. 4, no. 5

    International Nuclear Information System (INIS)

    1995-05-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains comments on the ITER project by the Permanent Representative of the Russian Federation to the International Organizations in Vienna; a report on the ITER Magnet Technical Meeting held at the Joint Work Site at Naka, Japan, April 19-21, 1995; and a contribution entitled ''ITER spouses cross the cultures''

  14. ITER EDA newsletter. V. 2, no. 2

    International Nuclear Information System (INIS)

    1993-02-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains a progress report by the Director, a report on the completion of the first activities of the Special Work Group 2 (SWG-2), a report on a magnet technical meeting, held at Naka, Japan, 26-29 January 1993, and on the US Home Team National Meeting, 25-26 January 1993

  15. ITER EDA Newsletter. V. 3, no. 8

    International Nuclear Information System (INIS)

    1994-08-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on the sixth ITER council meeting; introduces the newly appointed ITER director and reports on his address to the ITER council. The vacuum tank for the ITER model coil testing, installed at JAERI, Naka, Japan is also briefly described

  16. ITER EDA newsletter. V. 10, no. 6

    International Nuclear Information System (INIS)

    2001-06-01

    This ITER EDA Newsletter issue includes information about the ITER Management Advisory Committee Meeting held in Vienna on 16 July 2001 and also a summary of the ninth ITER Technical Meeting on safety and environment held at the ITER Garching Joint Work site, 8 to 10 May, 2001

  17. ITER EDA newsletter. V. 7, no. 12

    International Nuclear Information System (INIS)

    1998-12-01

    This edition of the ITER EDA Newsletter is dedicated to celebrate the achievements of the ITER activities at the San Diego Joint Work Site. Articles by E. Velikhov, A. Davies and R. Aymar mark the final days of American participation in the ITER program

  18. ITER EDA Newsletter. V. 3, no. 6

    International Nuclear Information System (INIS)

    1994-06-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains reports on the Technical Committee Meeting of the Working Group on Gyrotrons and Windows, held at the Garching Joint Work Site from 16-18 May 1994, and on the Technical Committee Meeting on the ITER Power Supply held at the Naka Joint Work Site from May 10-13, 1994. 1 tab

  19. ITER EDA newsletter. V. 8, no. 9

    International Nuclear Information System (INIS)

    1999-09-01

    This edition of the ITER EDA Newsletter contains a contribution by the ITER Director, R. Aymar, on the subject of developments in ITER Physics R and D report on the completion of the ITER central solenoid model coils installation by H. Tsuji, Head fo the Superconducting Magnet Laboratory at JAERI in Naka, Japan. Individual abstracts are prepared for each of the two articles

  20. ITER EDA newsletter. V. 6, no. 2

    International Nuclear Information System (INIS)

    1997-02-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter reports on the ITER divertor development project and its objectives; contains a report on the 16th Energy IAEA Fusion Conference (ITER and other Tokamak Issues) held in Montreal, Canada; 287 papers were selected by the Programme Committee for presentation and 178 posters were presented. 3 figs

  1. ITER EDA newsletter. V. 10, no. 3

    International Nuclear Information System (INIS)

    2001-03-01

    This issue contains a report on the meeting of the ITER Council (M. Drew), a report on the ITER EDA status (Dr. R. Aymar), a report on the ITER Council tour of the Clarington Site (Dr. D. Dautovich) . Abstracts of the indivdual reports have been included in the database

  2. ITER EDA newsletter. V. 7, No. 3

    International Nuclear Information System (INIS)

    1998-03-01

    This issue of the ITER Newsletter contains an article of the Status of the ITER EDA and the progress of the ITER activities and a report on the 5th Technical Meeting on Quality which was held in San Diego on 20-22 October 1997

  3. ITER EDA newsletter. V. 8, no. 11

    International Nuclear Information System (INIS)

    1999-11-01

    This ITER EDA Newsletter contains summary reports on the eleventh meeting of the ITER diagnostic expert group in Cadarache, France, on the ITER JCT presentation at the international conference on fusion reactor materials in Colorado Springs, USA and on the seventh workshop on plasma edge theory in fusion devices in Tajimi, Japan. Individual abstracts are prepared for the three contributions

  4. ITER EDA newsletter. V. 4, no. 9

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains reports on the first meeting of the ITER Test Blanket Working Group held 19-21 July 1995 at the ITER Garching Joint Work Site, and on the second workshop of the ITER Expert Group on Confinement and Transport.

  5. ITER EDA newsletter. V. 4, no. 9

    International Nuclear Information System (INIS)

    1995-09-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains reports on the first meeting of the ITER Test Blanket Working Group held 19-21 July 1995 at the ITER Garching Joint Work Site, and on the second workshop of the ITER Expert Group on Confinement and Transport

  6. ITER EDA newsletter. V. 8, no. 12

    International Nuclear Information System (INIS)

    1999-12-01

    This ITER EDA Newsletter reports about the ITER Management Advisory Committee Meeting in Naka, the ITER Technical Advisory Committee Meeting in Naka and the meeting of the ITER SWG-P2 in Vienna. A separate abstract is prepared for each meeting

  7. ITER EDA newsletter. V. 5, no. 9

    International Nuclear Information System (INIS)

    1996-09-01

    This issue of the Newsletter on the Engineering Design Activities (EDA) for the ITER project contains an overview of one of the seven large ITER Research and Development Projects identified by the ITER Director, namely the Vacuum Vessel Sector, as well as an account of computer animation created for ITER

  8. ITER EDA Newsletter. V. 4, no. 6

    International Nuclear Information System (INIS)

    1995-06-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains a report on the TAC-JCT (Technical Advisory Committee, Joint Technical Team) Informal Technical Reviews and the State Duma Hearings on Fusion (i.e., Parliamentary Hearing on Fusion held in the Russian Federation)

  9. ITER EDA Newsletter. V.4, no.2

    International Nuclear Information System (INIS)

    1995-02-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the exploits of the Special Working Group (SWG-2) designated in Protocol 1 to address task allocations and drafting of Protocol 2; and (ii) a report on the Tritium Plant Group Technical Meeting held at the Naka Joint Work Site on February 1-6, 1995

  10. ITER EDA newsletter. V. 2, no. 12

    International Nuclear Information System (INIS)

    1993-12-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains a report of the Second ITER Technical Committee Meeting on Safety, Environment, and Regulatory Approval, San Diego, USA, November 3-12, 1993, and a summary report on an ITER Magnet Technical Meeting, Naka, Japan, October 5-8, 1993

  11. ITER EDA newsletter. V. 2, no. 9

    International Nuclear Information System (INIS)

    1993-09-01

    This ITER EDA (Engineering Design Activities) Newsletter issue contains a report on the third meeting of the ITER Technical Advisory Committee, a summary report for the ITER Magnetic Technical Meeting, a brief account of the International Workshop on Nuclear Data for Fusion Reactor Technology, and a description of approved arrangements for visiting home team personnel

  12. The Earth Data Analytic Services (EDAS) Framework

    Science.gov (United States)

    Maxwell, T. P.; Duffy, D.

    2017-12-01

    Faced with unprecedented growth in earth data volume and demand, NASA has developed the Earth Data Analytic Services (EDAS) framework, a high performance big data analytics framework built on Apache Spark. This framework enables scientists to execute data processing workflows combining common analysis operations close to the massive data stores at NASA. The data is accessed in standard (NetCDF, HDF, etc.) formats in a POSIX file system and processed using vetted earth data analysis tools (ESMF, CDAT, NCO, etc.). EDAS utilizes a dynamic caching architecture, a custom distributed array framework, and a streaming parallel in-memory workflow for efficiently processing huge datasets within limited memory spaces with interactive response times. EDAS services are accessed via a WPS API being developed in collaboration with the ESGF Compute Working Team to support server-side analytics for ESGF. The API can be accessed using direct web service calls, a Python script, a Unix-like shell client, or a JavaScript-based web application. New analytic operations can be developed in Python, Java, or Scala (with support for other languages planned). Client packages in Python, Java/Scala, or JavaScript contain everything needed to build and submit EDAS requests. The EDAS architecture brings together the tools, data storage, and high-performance computing required for timely analysis of large-scale data sets, where the data resides, to ultimately produce societal benefits. It is is currently deployed at NASA in support of the Collaborative REAnalysis Technical Environment (CREATE) project, which centralizes numerous global reanalysis datasets onto a single advanced data analytics platform. This service enables decision makers to compare multiple reanalysis datasets and investigate trends, variability, and anomalies in earth system dynamics around the globe.

  13. ITER EDA newsletter. V. 5, no.1

    International Nuclear Information System (INIS)

    1996-01-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains reports on the RF-Based ITER JCT (Joint Central Team) Support Design Team (by N. Kornev), the third international workshop on plasma disruptions (by Dr. A. Hassanein and Dr. V. Litunovski) held at Obninsk, Russia, September 28-29, 1995, and the IAEA Advisory Group Meeting on Completion of Fendl-1 and the start of Fendl-2 (by Dr. A.B. Pashchenko); the Fendl library is a comprehensive collection of high-quality nuclear data, selected from the various existing national data libraries, covering the necessary nuclear input data for all physics and engineering aspects of the material development, design, operation, and safety of the ITER project in its current EDA phase

  14. ITER EDA newsletter. V. 1, no. 2

    International Nuclear Information System (INIS)

    1992-12-01

    This second issue of the ITER Newsletter during the EDA (Engineering Design Activities) reports on (i) the second ITER Council Meeting held in the Russian Research Centre (RRC) ''Kurchatov Institute'', Moscow, Russia, December 15-16, 1992, (ii) the opening ceremony of the ITER Council Office at the RRC, (iii) the first meeting of the ITER Management Advisory Committee (MAC), (iv) the start-up of the ITER EDA at Garching, Germany, (v) descriptions of the ITER Co-Centres at Naka, Japan, and (vi) San Diego, USA, (vii) contact persons activities, (viii) the adoption by the ITER Council of the recommendations by the Special Working Group 1 (SWG-1), (ix) news in brief, and (x) coming events

  15. ITER EDA newsletter. V. 8, no. 10

    International Nuclear Information System (INIS)

    1999-10-01

    This ITER EDA Newsletter contains summary reports on the seventh meeting of the ITER physics expert group on energetic particles, heating and steady state operations in Frascati, Italy, on the fifth international symposium on fusion nuclear technology in Rome, Italy and on the IAEA technical committee meeting on electron cyclotron resonance heating physics and technology for fusion devices in Oh-arai, Japan. Individual abstracts are prepared for the three contributions

  16. ITER EDA newsletter. V. 7, no. 11

    International Nuclear Information System (INIS)

    1998-11-01

    This ITER EDA Newsletter contains a report on the delivery of the outer module of the CS model coil to Naka by K. Okuno et al, a special lecture by H. Yoshikawa, the president of the Science Council of Japan on the future outlook of nuclear fusion and a report on an ITER display during the 17th IAEA Fusion Energy Conference, held in Yokohama, Japan, from October 19 to 24, 1998

  17. ITER EDA Newsletter. V. 6, no. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    This issue of the newsletter on Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on Second International Industries` Liaison meeting which was held in Tokyo on 2-4 April 1997 (by Y. Kaneki, JAIF, Japan); an overview report on the Blanket project (by A. Cardella, I.Ioki (ITER Central Team), W. Daenner (EU Home Team)); and a progress report on microwave reflectometry (by J. Sanchez, Madrid, Spain).

  18. ITER EDA newsletter. V. 5, no. 10

    International Nuclear Information System (INIS)

    1996-10-01

    This issue of the newsletter on the Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on the Fifth ITER Technical Meeting on Safety, Environment, and Regulatory Approval, held September 29 - October 7, 1996 at the ITER San Diego Joint Work Site; and a report on the Fifth ITER Diagnostics Expert Group Workshop and Technical Meeting on Diagnostics held in Montreal, Canada, 12-13 October 1996

  19. ITER EDA Newsletter. V.2, no.5

    International Nuclear Information System (INIS)

    1993-05-01

    This ITER EDA (Engineering Design Activities), Newsletter issue includes reports on the third ITER council meeting in Tokyo on the involvement of other countries, on an outline of the report by the Management Advisory Committee (MAC), on such involvement, and on the improvement by the MAC and the ITER Council to proceed with Task Agreements on the Research and Development programme of the Superconductor Coils and Structures Division

  20. ITER EDA Newsletter. V. 2, no. 3

    International Nuclear Information System (INIS)

    1993-03-01

    This ITER EDA (Engineering Design Activities) Newsletter issue includes a description of the ITER Joint Central Team's management, the ITER Management System and supporting software progress, activities of the Special Working Group 2, a brief summary of a technical meeting on the experimental approach to the physics of the high density divertor, a summary on the status of the International Fusion Evaluated Nuclear Data Library (FENDL), and an obituary on Dr. Henry Seligman (IAEA)

  1. ITER EDA Newsletter. V.4, no.1

    International Nuclear Information System (INIS)

    1995-01-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the seventh ITER Council Meeting held at the Naka Joint Work Site on 14-15 December 1994, (ii) the ''Confinement Modelling and Database Expert Group Workshop'' held in Seville, Spain, 3-4 October 1994, and (iii) the first meeting of the International Organizing Committee for the Seventh International Fusion Reactor Materials Conference

  2. ITER EDA Newsletter. V. 3, no. 7

    International Nuclear Information System (INIS)

    1994-07-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on the sixth meeting on the ITER management advisory committee (MAC-6); on the sixth meeting of the ITER technical advisory committee (TAC-6); a summary of a magnet technical meeting, held at Naka, Japan, June 27-30 1994 is also included. It finally contains an in memoriam on the passing away of Dr. A.I. Kostenko

  3. ITER EDA Newsletter. V. 3, no. 12

    International Nuclear Information System (INIS)

    1994-12-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the seventh Meeting of the Technical Advisory Committee (TAC-7) held at the Joint Work Site in Naka, Japan, 5-7 December 1994; (ii) the seventh Meeting of the ITER Management Advisory Committee (MAC-7) held at the Naka Joint Work Site, November 30 - December 1, 1994; (iii) the Magnet Technical Meeting, held at the Naka Joint Work Site on November 8-11, 1994

  4. ITER EDA Newsletter. V. 4, no. 3

    International Nuclear Information System (INIS)

    1995-03-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the ITER Magnet Technical Meeting held at the Naka Joint Work Site on February 7-10, 1995; (ii) the Second Technical Meeting on ITER Power Supply held on February 20-24, 1995, in St. Petersburg (Russian Federation); and (iii) a description by the Nuclear Data section of the IAEA (Vienna, Austria) on the availability and current status of the FENDL-1 Nuclear Data Libraries for fusion applications

  5. ITER EDA Newsletter. V. 6, no. 5

    International Nuclear Information System (INIS)

    1997-05-01

    This issue of the newsletter on Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on Second International Industries' Liaison meeting which was held in Tokyo on 2-4 April 1997 (by Y. Kaneki, JAIF, Japan); an overview report on the Blanket project (by A. Cardella, I.Ioki (ITER Central Team), W. Daenner (EU Home Team)); and a progress report on microwave reflectometry (by J. Sanchez, Madrid, Spain)

  6. ITER EDA Newsletter. V. 4, no. 4

    International Nuclear Information System (INIS)

    1995-04-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter reports on (i) the Second Meeting of the ITER Physics Expert Group on Diagnostics held at the Japanese Atomic Energy Research Institute, Naka, Japan, on February 8-10, 1995; and (ii) a summary of the Second Workshop of the Confinement Modelling and Database Expert Group, held at the ITER San Diego Work Site, March 13-15, 1995

  7. ITER EDA newsletter. V. 9, no. 11

    International Nuclear Information System (INIS)

    2000-11-01

    This issue of the ITER EDA Newsletter contains discussions of three meetings, i.e., (1) the Third ITER International Industry Liaison Meeting held in Toronto, Canada (November 7-9, 2000), (2) an informal meeting on ITER developments held in Sorrento, Italy (October 9, 2000), and (3) the Thirteenth Meeting of the ITER Physics Expert Group on Diagnostics held in Naka, Japan (September 21-22, 2000)

  8. ITER EDA Newsletter. V. 3, no. 11

    International Nuclear Information System (INIS)

    1994-11-01

    This ITER EDA (Engineering Design Activities) Newsletter issue reports on (i) the third Technical Meeting on Safety and Environment held at the San Diego Joint Work Site, October 10-14, 1994; (ii) the ITER Expert Group Meeting on Disruptions, Plasma Control and MHD, held in Seville, Spain, September 29-30, 1994; in addition to a brief contribution on aspects of family life for foreigners at the Naka Joint Work Site

  9. ITER EDA newsletter. V. 2, no. 10

    International Nuclear Information System (INIS)

    1993-10-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains progress reports on the Fourth ITER Council Meeting in San Diego, 29 September - 1 October 1993, on the Third Meeting of the ITER Management Advisory Committee (MAC) in Naka, Japan, 16-17 September 1993, and on the flag raising ceremony at the US hosted joint work site in San Diego, California, 1 October 1993

  10. Considerations about the European Decommissioning Academy (EDA)

    International Nuclear Information System (INIS)

    Slugen, V.; Hinca, R.

    2014-01-01

    According to analyses presented at EC meeting focused on decommissioning organized at 11.9.2012 in Brussels, it was stated that at least 500 new international experts for decommissioning will be needed in Europe up to 2025, which means about 35 per year.Having in mind the actual EHRO-N report from 2013 focused on operation of nuclear facilities and an assumption that the ratio between nuclear experts, nuclearized and nuclear aware people is comparable also for decommissioning (16:74:10), as well as the fact that the special study branch for decommissioning in the European countries almost does not exist, this European Decommissioning Academy (EDA) could be helpful in the overbridging this gap.For the first run of the EDA scheduled on 2014 we would like to focus on VVER decommissioning issues because this reactor type is the most distributed design in the world and many of these units are actually in decommissioning process or will be decommissioned in the near future in Europe.A graduate of the European Decommissioning Academy (EDA) should have at least bachelor level from technical or natural science Universities or Colleges and at least one year working experiences in the area of NPP decommissioning or nuclear power engineering. This study creates prerequisites for acquiring and completion of professional and specialized knowledge in the subjects which are described. (authors)

  11. ITER EDA Newsletter. V. 4, no. 7

    International Nuclear Information System (INIS)

    1995-07-01

    This ITER EDA (Engineering Design Activities) Newsletter issue contains reports on (i) the 8th meeting of the ITER Technical Advisory Committee (TAC-8) held on June 29 - July 7, 1995 at the ITER San Diego Work Site, (ii) the 8th meeting of the ITER Management Advisory Committee (MAC-8) held at the ITER San Diego Work Site on July 9-10, 1995, (iii) the 33rd meeting of the International Fusion Research Council (FRC), held July 11, 1995 at the IAEA Headquarters in Vienna, Austria, and (iv) the ITER participation in the fifth topical meeting on Tritium Technology in Fission, Fusion and Isotopic Applications

  12. ITER EDA newsletter. V. 3, no. 2

    International Nuclear Information System (INIS)

    1994-02-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains reports on the Fifth ITER Council Meeting held in Garching, Germany, 27-28 January 1994, a visit (28 January 1994) of an international group of Harvard Fellows to the San Diego Joint Work Site, the Inauguration Ceremony of the EC-hosted ITER joint work site in Garching (28 January 1994), on an ITER Technical Meeting on Assembly and Maintenance held in Garching, Germany, January 19-26, 1994, and a report on a Technical Committee Meeting on radiation effects on in-vessel components held in Garching, Germany, November 15-19, 1993, as well as an ITER Status Report

  13. ITER EDA newsletter. V. 5, no. 12

    International Nuclear Information System (INIS)

    1996-12-01

    This issue of the newsletter on the Engineering Design Activities (EDA) for the ITER Tokamak project contains a report on the Eleventh ITER Council Meeting held on December 17-18, 1996 in Tokyo, Japan; a report on the Eleventh Meeting of the ITER Technical Advisory Committee (TAC-11) Meeting held 3-7 December, 1996, at the ITER Naka Joint Work Site, Japan; and a report on the Fifth Workshop of the Confinement Modelling and Database Expert Group held in Montreal, Canada, October 13-16, 1996

  14. ITER EDA Newsletter. V. 3, no. 9

    International Nuclear Information System (INIS)

    1994-09-01

    This ITER EDA (Engineering Design Activities) Newsletter issue contains a description of the ITER Physics Research and Development (F.Perkins), a report on the first meeting of the ITER Divertor Physics and Divertor Modelling and Database Expert Groups (D. Post, G. Janeschitz, R. Stambaugh, M. Shimada), a report on the first meeting of the ITER Physics Expert Group on Diagnostics (A.E. Costley and K.M. Young), and a contribution entitled ''to meet or not to meet? If yes, for how long?'' (L. Golubchikov)

  15. ITER EDA Newsletter. V. 4, no. 8

    International Nuclear Information System (INIS)

    1995-08-01

    This ITER EDA (Engineering Design Activities) Newsletter issue contains reports on the 8th meeting of the ITER council and on the first Special Review Group (SRG) meeting held 21-23 June, 1995, at the San Diego Joint Work Site, USA. The SWG was established in July 1994 to review the technical, social, and the safety and environmental requirements for siting ITER which will be prepared by the Director and the JCT, and to report the results of the review to the council. Furthermore, a description of the design office at the Garching Joint Work Site is given

  16. ITER EDA newsletter. V. 6, no. 4

    International Nuclear Information System (INIS)

    1997-04-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter reports on the Toroidal Field Model Coil Project (Coil System, Objectives, Design, Project Management, Testing); contains a report of A Combined Workshop of Confinement Modeling and Database and Confinement and Transport Expert Groups held at the San Diego ITER Joint Work Site from April 14. to 18. Progress and status on implementing the ITER Confinement R and D needs as specified at the last Workshops of the Expert Groups in Montreal (Oct. 1996) were reported. 7 figs, 1 tab

  17. Field Trial of the Enhanced Data Authentication System (EDAS)

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Maikael A.; Baldwin, George T.; Hymel, Ross W

    2016-05-01

    The goal of the field trial of EDAS was to demonstrate the utility of secure branching of operator instrumentation for nuclear safeguards, identify any unforeseen implementation and application issues with EDAS, and confirm whether the approach is compatible with operator concerns and constraints.

  18. ITER EDA newsletter. V. 10, no. 4

    International Nuclear Information System (INIS)

    2001-04-01

    This ITER EDA Newsletter presents an overview of the Fourteenth Meeting of the ITER Physics Expert Group on Diagnostics which was held at the Institute for Plasma Physics, Juelich, Germany, 21-23 March 2001. The summary of the Meeting covers the discussions of the Expert Group as well as developments reported on similar meetings concerning ongoing work in diagnostic design and ITER relevant diagnostic development work which took place nearly at the same time. In addition, the outline of the material treated at the International Workshop on the Confinement Database and Modelling Expert Group in collaboration with the Edge and Pedestal Physics Expert Group which was held on 2-6 April 2001 at the Plasma Physics Research Centre of Lausanne (CRPP) Switzerland is presented

  19. ITER EDA newsletter. V. 4, no. 11

    International Nuclear Information System (INIS)

    1995-11-01

    This issue of the ITER EDA (Engineering Design Activities) Newsletter contains a report on the Ninth Meeting of the ITER Management Advisory Committee held in St. Petersburg, Russia, on November 3, 1995; a report on the Seventh International Conference on Fusion Reactor Materials held at Obninsk, Russia, 25-29 September, 1995; on the presentation of the ITER Project during a symposium on fusion energy held at Champaign, Illinois, USA, October 1-5, 1995; and on two meetings on ITER diagnostics, i.e., an international workshop on diagnostics for ITER held in Varenna, Italy, 28 August - 1 September, 1995; followed by the Third Diagnostics Expert Group Workshop held September 4-5 in the same location

  20. Väiketootjad jaekaupmeeste surve all / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Väiketootjatel on probleeme oma toodangu saamisega suurtesse kauplusekettidesse, sest kaupmeeste esitatud tingimusi on raske täita. Kommenteerivad Sirje Potisepp ja Anti Orav. Vaata samas: Eda-Liis Kann; Andres Kärssin. Kaupluskettide valikut suunavad tarbijad

  1. 75 FR 4259 - Revisions to the EDA Regulations

    Science.gov (United States)

    2010-01-27

    ... review for the RLF Grant every (3) three years,'' when the intention was to give EDA the ability to... entrepreneurship. An Investment will embrace the principles of entrepreneurship, enhance Regional industry clusters...

  2. EDA-containing fibronectin increases proliferation of embryonic stem cells.

    Directory of Open Access Journals (Sweden)

    Noelia Losino

    Full Text Available Embryonic stem cells (ESC need a set of specific factors to be propagated. They can also grow in conditioned medium (CM derived from a bovine granulosa cell line BGC (BGC-CM, a medium that not only preserves their main features but also increases ESC´s proliferation rate. The mitogenic properties of this medium were previously reported, ascribing this effect to an alternative spliced generated fibronectin isoform that contains the extra domain A (FN EDA(+. Here, we investigated if the FN EDA(+ isoform increased proliferation of mouse and human ES cells. We analyzed cell proliferation using conditioned media produced by different mouse embryonic fibroblast (MEF lines genetically engineered to express FN constitutively including or excluding the EDA domain (FN EDA(-, and in media supplemented with recombinant peptides containing or not the EDA. We found that the presence of EDA in the medium increased mouse and human ESC's proliferation rate. Here we showed for the first time that this FN isoform enhances ESC's proliferation. These findings suggest a possible conserved behavior for regulation of ES cells proliferation by this FN isoform and could contribute to improve their culturing conditions both for research and cell therapy.

  3. ITER EDA newsletter. V. 10, no. 1

    International Nuclear Information System (INIS)

    2001-01-01

    This article provides a summary of results of the ITER Physics Committee Meeting, which was held on 14 October 2000 at the ITER Garching Joint Work Site, Germany. The ITER Physics Committee is the body responsible for overseeing, through the seven specialized Expert Groups, the R and D activities contributed voluntarily by the ITER Parties. The Parties' Physics Designated Persons, the Chairs and Co-Chairs of ITER Physics Expert Groups and the JCT members involved attended the Meeting. As usual, the meeting was chaired by the ITER Director, Dr. R. Aymar, who reported on the status of the ITER EDA. Dr. Aymar described the steps being taken in preparing the ITER-FEAT Final Design Report (FDR), and further stated that the Report would be available in time to be of benefit to the Negotiations on the ITER Joint Implementation, expected to start around May 2001. All Parties recognize that the ITER Physics Expert Group structure has been useful in focusing the tokamak physics activity on the ITER-relevant issues and provides an efficient worldwide collaboration on confirming innovative solutions. The concept of an international workshop to be organized as a pre-meeting of each Expert Group meeting, in order to involve U.S. scientists in the discussion of generic tokamak physics issues, was introduced in 2000, with some success, and its goal should be pursued

  4. European Decommissioning Academy (EDA). Ready to start

    International Nuclear Information System (INIS)

    Slugen, Vladimir

    2015-01-01

    According to analyses presented at EC meeting focused on decommissioning organized at 11 September 2012 in Brussels, it was stated that at least 2,000 new international experts for decommissioning will be needed in Europe up to 2025, which means about 150 each year. The article describes the European Decommissioning Academy (EDA) which is prepared for the first term in June 2015 in Slovakia. The main goal is a creation of new nuclear experts generation for decommissioning via the Academy, which will include lessons, practical exercises in laboratories as well as 2 days on-site training at NPP V-1 in Jaslovske Bohunice (Slovakia). Four days technical tour via most interesting European decommissioning facilities in Switzerland and Italy are planned as well. After the final exam, there is the option to continue in knowledge collection via participation at the 2nd Eastern and Central European Decommissioning (ECED) conference in Trnava (Slovakia). We would like to focus on VVER decommissioning issues because this reactor type is the most distributed design in the world and many of these units are actually in decommissioning process or will be decommissioned in the near future.

  5. 76 FR 5501 - Request for Comments: Review and Improvement of EDA's Regulations

    Science.gov (United States)

    2011-02-01

    ... creation and growth of Regional Innovation Clusters (RICs). In addition, EDA has identified potential... our stakeholders and the American people. 1. Regional Innovation Clusters (RICs) EDA supports the..., February 1, 2011 / Proposed Rules#0;#0; [[Page 5501

  6. European Decommissioning Academy (EDA) - successful 1. run in june 2015

    International Nuclear Information System (INIS)

    Slugen, V.; Hornacek, M.

    2015-01-01

    Experiences from the first run of the European Decommissioning Academy (EDA) are reported in details. EDA was created at the Slovak University of Technology in Bratislava Slovakia, based on discussion and expressed needs declared at many international meetings including ECED2013. The first run successfully passed 14 participants during 7.-20.6. 2015. Academy was focused on decommissioning issues via lessons, practical exercises in laboratories, on-site training prepared at NPP V-1 in Jaslovske Bohunice, Slovakia as well as 4 days technical tour to other European decommissioning facilities (Swiss, Italy), respectively. Detailed information can be found at http://kome.snus.sk/inpe/. (authors)

  7. Pariisi-kiri / Aire Allikmets

    Index Scriptorium Estoniae

    Allikmets, Aire

    1997-01-01

    Fanny de Siversile pühendatud vastuvõtust College de France'i Sinises Salongis 27. märtsil 1997 ja temale pühendatud koguteosest 'Contacts de langues et de cultures dans l'aire Baltique' (koost. M. M. Jocelyne Fernendez ja Raimo Raag)

  8. Needs for European decommissioning academy (EDA)

    International Nuclear Information System (INIS)

    Slugen, Vladimir

    2014-01-01

    According to analyses presented at EC meeting focused on decommissioning organized at 11.9.2012 in Brussels, it was stated that at least 500 new international experts for decommissioning will be needed in Europe up to 2025, which means about 35 per year. Having in mind the actual EHRO-N report from 2013 focused on operation of nuclear facilities and an assumption that the ratio between nuclear experts, nuclearized and nuclear aware people is comparable also for decommissioning, as well as the fact that the special study branch for decommissioning in the European countries almost does not exist, this European Decommissioning Academy (EDA) could be helpful in the over-bridging this gap. The main goal is - from about 74% of nuclearized experts (graduated at different technical Universities and increased their nuclear knowledge and skills mostly via on-job training and often in the area of NPP operation) to create nuclear experts for decommissioning via our post-gradual coursed organized in two semester study at our Academy, which will include the lessons, practical exercises in our laboratories, on-site training at NPP V-1 in Jaslovske Bohunice, Slovakia as well as 3 days technical tour to JAVYS (Slovakia), UJV Rez (Czech Rep.) and PURAM (Hungary), respectively. Beside the exams in selected topics (courses), the final thesis written under supervision of recognized experts will be the precondition for graduation and certification of the participants. For the first run of the EDA scheduled on 2014 we would like to focus on VVER decommissioning issues because this reactor type is the most distributed design in the world and many of these units are actually in decommissioning process or will be decommissioned in the near future in Europe. The growing decommissioning market creates a potential for new activities, with highly skilled jobs in an innovative field, involving high-level technologies. A clear global positioning of the EU will stimulate the export of know-how to

  9. 76 FR 19976 - Proposed Information Collection; Comment Request; Survey of EDA Grant Process Improvement

    Science.gov (United States)

    2011-04-11

    ...; Comment Request; Survey of EDA Grant Process Improvement AGENCY: Economic Development Administration.... In 2010, EDA made improvements in its grant application process. The proposed short survey of five to... improvements to the grant application process and to make any necessary adjustments. EDA would like to conduct...

  10. EDAS-manual. SATAN - system to analyze tremendous amounts of nuclear data. Vol. 2

    International Nuclear Information System (INIS)

    Goeringer, H.; Gralla, S.; Malzacher, P.; Richter, M.; Schall, D.; Winkelmann, K.

    1988-09-01

    The system to analyze tremendous amounts of nuclear data (SATAN) shows different steps of a special experiment data evaluation called 'Linearisation'. The report contains the EDAS-manual with EDAS-command, TSO-command, macro and procedure. Syntax and usage of EDAS macros are explained. (DG)

  11. ITER EDA newsletter. V. 2, Nos. 7/8

    International Nuclear Information System (INIS)

    1993-01-01

    This ITER EDA (Engineering Design Activities) Newsletter issue includes a description of the ITER Design Integration Division, and reports on the 5th IAEA Technical Committee Meeting on Developments in Fusion Safety held in Toronto, Canada, 7 - 11 June 1993, and on the International Atomic Energy Agency's Atomic and Plasma-Material Interaction Data Activities in support of the ITER Engineering Design Activities

  12. Electronic Systems for Spacecraft Vehicles: Required EDA Tools

    Science.gov (United States)

    Bachnak, Rafic

    1999-01-01

    The continuous increase in complexity of electronic systems is making the design and manufacturing of such systems more challenging than ever before. As a result, designers are finding it impossible to design efficient systems without the use of sophisticated Electronic Design Automation (EDA) tools. These tools offer integrated simulation of the electrical, mechanical, and manufacturing functions and lead to a correct by design methodology. This report identifies the EDA tools that would be needed to design, analyze, simulate, and evaluate electronic systems for spacecraft vehicles. In addition, the report presents recommendations to enhance the current JSC electronic design capabilities. This includes cost information and a discussion as to the impact, both positive and negative, of implementing the recommendations.

  13. High-resolution mapping of the x-linked hypohidrotic ectodermal dysplasia (EDA) locus

    Energy Technology Data Exchange (ETDEWEB)

    Zonana, J.; Jones, M.; Litt, M.; Kramer, P.; Browne, D.; Becker, H.W. (Oregon Health Sciences Univ., Portland, OR (United States)); Brockdorff, N.; Rastan, S. (Medical Council Clinical Research Centre, Harrow (United Kingdom)); Davies, K.P.; Clarke, A. (Univ. of Wales College of Medicine, Cardiff (United Kingdom)) (and others)

    1992-11-01

    The X-linked hypohidrotic ectodermal dysplasia (EDA) locus has been previously localized to the subchromosomal region Xq11-q21.1. The authors have extended previous linkage studies and analyzed linkage between the EDA locus and 10 marker loci, including five new loci, in 41 families. Four of the marker loci showed no recombination with the EDA locus, and six other loci were also linked to the EDA locus with recombination fractions of .009-.075. Multipoint analysis gave support to the placement of the PGK1P1 locus proximal to the EDA locus and the DXS453 and PGK1 loci distal to EDA. Further ordering of the loci could be inferred from a human-rodent somatic cell hybrid derived from an affected female with EDA and an X;9 translocation and from studies of an affected male with EDA and a submicroscopic deletion. Three of the proximal marker loci, which showed no recombination with the EDA locus, when used in combination, were informative in 92% of females. The closely linked flanking polymorphic loci DXS339 and DXS453 had heterozygosites of 72% and 76%, respectively, and when used jointly, they were doubly informative in 52% of females. The human DXS732 locus was defined by a conserved mouse probe pcos169E/4 (DXCrc169 locus) that consegregates with the mouse tabby (Ta) locus, a potential homologue to the EDA locus. The absence of recombination between EDA and the DXSA732 locus lends support to the hypothesis that the DXCrc169 locus in the mouse and the DXS732 locus in humans may contain candidate sequences for the Ta and EDA genes, respectively. 36 refs., 1 fig., 5 tabs.

  14. Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.

    Science.gov (United States)

    Kowalczyk-Quintas, Christine; Willen, Laure; Dang, Anh Thu; Sarrasin, Heidi; Tardivel, Aubry; Hermes, Katharina; Schneider, Holm; Gaide, Olivier; Donzé, Olivier; Kirby, Neil; Headon, Denis J; Schneider, Pascal

    2014-02-14

    Development of ectodermal appendages, such as hair, teeth, sweat glands, sebaceous glands, and mammary glands, requires the action of the TNF family ligand ectodysplasin A (EDA). Mutations of the X-linked EDA gene cause reduction or absence of many ectodermal appendages and have been identified as a cause of ectodermal dysplasia in humans, mice, dogs, and cattle. We have generated blocking antibodies, raised in Eda-deficient mice, against the conserved, receptor-binding domain of EDA. These antibodies recognize epitopes overlapping the receptor-binding site and prevent EDA from binding and activating EDAR at close to stoichiometric ratios in in vitro binding and activity assays. The antibodies block EDA1 and EDA2 of both mammalian and avian origin and, in vivo, suppress the ability of recombinant Fc-EDA1 to rescue ectodermal dysplasia in Eda-deficient Tabby mice. Moreover, administration of EDA blocking antibodies to pregnant wild type mice induced in developing wild type fetuses a marked and permanent ectodermal dysplasia. These function-blocking anti-EDA antibodies with wide cross-species reactivity will enable study of the developmental and postdevelopmental roles of EDA in a variety of organisms and open the route to therapeutic intervention in conditions in which EDA may be implicated.

  15. Generation and Characterization of Function-blocking Anti-ectodysplasin A (EDA) Monoclonal Antibodies That Induce Ectodermal Dysplasia*

    Science.gov (United States)

    Kowalczyk-Quintas, Christine; Willen, Laure; Dang, Anh Thu; Sarrasin, Heidi; Tardivel, Aubry; Hermes, Katharina; Schneider, Holm; Gaide, Olivier; Donzé, Olivier; Kirby, Neil; Headon, Denis J.; Schneider, Pascal

    2014-01-01

    Development of ectodermal appendages, such as hair, teeth, sweat glands, sebaceous glands, and mammary glands, requires the action of the TNF family ligand ectodysplasin A (EDA). Mutations of the X-linked EDA gene cause reduction or absence of many ectodermal appendages and have been identified as a cause of ectodermal dysplasia in humans, mice, dogs, and cattle. We have generated blocking antibodies, raised in Eda-deficient mice, against the conserved, receptor-binding domain of EDA. These antibodies recognize epitopes overlapping the receptor-binding site and prevent EDA from binding and activating EDAR at close to stoichiometric ratios in in vitro binding and activity assays. The antibodies block EDA1 and EDA2 of both mammalian and avian origin and, in vivo, suppress the ability of recombinant Fc-EDA1 to rescue ectodermal dysplasia in Eda-deficient Tabby mice. Moreover, administration of EDA blocking antibodies to pregnant wild type mice induced in developing wild type fetuses a marked and permanent ectodermal dysplasia. These function-blocking anti-EDA antibodies with wide cross-species reactivity will enable study of the developmental and postdevelopmental roles of EDA in a variety of organisms and open the route to therapeutic intervention in conditions in which EDA may be implicated. PMID:24391090

  16. Parametric analysis and operational performance of EDA-ITER

    International Nuclear Information System (INIS)

    Murakami, Yoshiki; Tsunematsu, Toshihide; Fujieda, Hirobumi.

    1994-06-01

    Confinement capability of EDA-ITER is investigated by using a 0-D model based on CDA physics design guidelines. Confinement enhancement factor (H-factor) is evaluated and required fusion power (P FUS ) for the ignition is calculated. It is found that ignition is possible in H-mode plasma (H=2) when helium accumulation (He) is 10% and P FUS ≥ 1 GW. For Rebut-Lallia scaling law, L-mode (H=1) ignition is possible when P FUS ≥ 3 GW. The required fusion power is, however, more than 4 GW even in H-mode plasmas when the helium accumulation is 20%. Therefore, it is an important future work to study how much helium accumulates in a burning plasma. Capability of steady-state mode operation is also investigated. Required current-drive power for H-mode plasma is about 140 MW when He=10% and the fusion gain Q is more than 5. If the enhanced confinement (H∼3) in high safety factor region (q∼5) can be adoptable, steady-state operation with Q>10 is possible and the required current-drive power is about 60 MW. In spite of the larger fusion power, the divertor heat load of EDA-ITER calculated by scaling models is comparable or smaller than that of CDA-ITER due to the longer connection length. Thermal instability of EDA-ITER is also investigated. The growth time is about 15 s for ITER89 power scaling law. Fusion power excursion is investigated in very preliminary way. It is found that the power rises from 1.5 GW to 3 GW in about 100 s if there is no control. Although this instability could be stabilized by beta limit or helium accumulation effect, it is an important future work since it may cause severe problem. (author)

  17. Involvement of the EU industry in ITER EDA

    International Nuclear Information System (INIS)

    Bogusch, E.

    2001-01-01

    Since the fifties, European industry has been involved in research and development in the field of nuclear fusion as a potential future source of energy. Early contributions mainly included deliveries of plant components and services to experimental facilities. In the Engineering Design Activities (EDA) phase of the planned multinational International Thermonuclear Experimental Reactor (ITER) in 1993 to 2001 this commitment of industry was intensified. Industries from seven European countries participated in the project with various contributions, e.g., in the development, design, and manufacture of components, and in the development of methods of planning and executing the complex ITER project. These activities were accompanied by an extensive R and D program. e.g., about materials and methods of manufacturing ITER components. In this way, European industry made an important contribution to the further development of nuclear fusion within the framework of ITER EDA activities, and will be able to continue this work intensively in the expected ITER construction phase to follow. (orig.) [de

  18. ITER-EDA physics design requirements and plasma performance assessments

    International Nuclear Information System (INIS)

    Uckan, N.A.; Galambos, J.; Wesley, J.; Boucher, D.; Perkins, F.; Post, D.; Putvinski, S.

    1996-01-01

    Physics design guidelines, plasma performance estimates, and sensitivity of performance to changes in physics assumptions are presented for the ITER-EDA Interim Design. The overall ITER device parameters have been derived from the performance goals using physics guidelines based on the physics R ampersand D results. The ITER-EDA design has a single-null divertor configuration (divertor at the bottom) with a nominal plasma current of 21 MA, magnetic field of 5.68 T, major and minor radius of 8.14 m and 2.8 m, and a plasma elongation (at the 95% flux surface) of ∼1.6 that produces a nominal fusion power of ∼1.5 GW for an ignited burn pulse length of ≥1000 s. The assessments have shown that ignition at 1.5 GW of fusion power can be sustained in ITER for 1000 s given present extrapolations of H-mode confinement (τ E = 0.85 x τ ITER93H ), helium exhaust (τ* He /τ E = 10), representative plasma impurities (n Be /n e = 2%), and beta limit [β N = β(%)/(I/aB) ≤ 2.5]. The provision of 100 MW of auxiliary power, necessary to access to H-mode during the approach to ignition, provides for the possibility of driven burn operations at Q = 15. This enables ITER to fulfill its mission of fusion power (∼ 1--1.5 GW) and fluence (∼1 MWa/m 2 ) goals if confinement, impurity levels, or operational (density, beta) limits prove to be less favorable than present projections. The power threshold for H-L transition, confinement uncertainties, and operational limits (Greenwald density limit and beta limit) are potential performance limiting issues. Improvement of the helium exhaust (τ* He /τ E ≤ 5) and potential operation in reverse-shear mode significantly improve ITER performance

  19. Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA Mutations

    Directory of Open Access Journals (Sweden)

    Michael D. Keller

    2011-11-01

    Full Text Available Ectodermal dysplasias (ED are uncommon genetic disorders resulting in abnormalities in ectodermally-derived structures. Though many ED-associated genes have been described, the NF-κB Essential Modulator (NEMO encoded by the IKBKG gene is unique in that mutations also result in severe humoral and cellular immunologic defects. We describe three unrelated kindreds with defects in both EDA and IKBKG resulting from an X-chromosome crossover. This demonstrates the importance of thorough immunologic consideration of patients with ED even when an EDA etiology is confirmed, and raises the possibility of a specific phenotype arising from coincident mutations in EDA and IKBKB.

  20. X-Linked Hypohidrotic Ectodermal Dysplasia: New Features and a Novel EDA Gene Mutation.

    Science.gov (United States)

    Savasta, Salvatore; Carlone, Giorgia; Castagnoli, Riccardo; Chiappe, Francesca; Bassanese, Francesco; Piras, Roberta; Salpietro, Vincenzo; Brazzelli, Valeria; Verrotti, Alberto; Marseglia, Gian L

    2017-01-01

    We described a 5-year-old male with hypodontia, hypohidrosis, and facial dysmorphisms characterized by a depressed nasal bridge, maxillary hypoplasia, and protuberant lips. Chromosomal analysis revealed a normal 46,XY male karyotype. Due to the presence of clinical features of hypohidrotic ectodermal dysplasia (HED), the EDA gene, located at Xq12q13.1, of the patient and his family was sequenced. Analysis of the proband's sequence revealed a missense mutation (T to A transversion) in hemizygosity state at nucleotide position 158 in exon 1 of the EDA gene, which changes codon 53 from leucine to histidine, while heterozygosity at this position was detected in the slightly affected mother; moreover, this mutation was not found in the publically available Human Gene Mutation Database. To date, our findings indicate that a novel mutation in EDA is associated with X-linked HED, adding it to the repertoire of EDA mutations. © 2017 S. Karger AG, Basel.

  1. The investigation of the interaction between NCP-EDA and bovine serum albumin by spectroscopic approaches

    Science.gov (United States)

    Yu, Xianyong; Lu, Shiyu; Yang, Ying; Li, Xiaofang; Yi, Pinggui

    2011-12-01

    The fluorescence and ultraviolet spectroscopies were explored to study the interaction between N-confused porphyrins-edaravone diad (NCP-EDA) and bovine serum albumin (BSA) under simulative physiological condition at different temperatures. The experimental results show that the fluorescence quenching mechanism between NCP-EDA and BSA is a combined quenching (dynamic and static quenching). The binding constants, binding sites and the corresponding thermodynamic parameters (Δ G, Δ H, and Δ S) of the interaction system were calculated at different temperatures. According to Förster non-radiation energy transfer theory, the binding distance between NCP-EDA and BSA was calculated to be 3.63 nm. In addition, the effect of NCP-EDA on the conformation of BSA was analyzed using synchronous fluorescence spectroscopy.

  2. Labor tirib haigused päevavalgele / Eda Laas ; interv. Eevi Kuht

    Index Scriptorium Estoniae

    Laas, Eda

    2005-01-01

    Piiral tegutseva veterinaar- ja toidulabori juhataja Eda Laas peab kõige ohtlikumaks uuritavaks loomahaiguseks ka inimesele levivat surmaga lõppevat marutaudi, mille vastu võitlemiseks on riik eriprogrammi kokku pannud

  3. The plasma position control of ITER EDA plasma

    International Nuclear Information System (INIS)

    Senda, Ikuo; Nishio, Satoshi; Tsunematsu, Toshihide; Nishino, Toru; Fujieda, Hirobumi.

    1994-09-01

    The study on the plasma position control of ITER EDA performed by Japan Home Team during the sensitivity study in 1994 is summarized. The controllabilities of plasmas in the Outline Design and elongated version are compared. The model used to describe the motion of the plasma is a rigid model. The PD feedback control is applied with respect to the displacements of the plasma from the equilibrium. Three types of fluctuations, which initiate the motion of the plasma, are examined, namely a finite horizontal fluctuation field, a small horizontal fluctuation field such that the motion of the plasma is governed by the passive structures and an abrupt change of the poloidal beta β p and internal inductance l i . In the simulations of finite horizontal fluctuation fields, controls depend on the strength of the fluctuations, for instance, 3-5V is needed for 5-10G of fluctuation fields in the Outline Design. When the fluctuation field is small and the plasma displacement grows in a characteristic time of the passive structures, a few volt of the control voltage is enough to obtain good controllability. It is shown that the control when (β p , l i ) changes simultaneously is demanding and a large control voltage is required to maintain satisfactory control. Comparing the elongated version with the Outline Design, the control voltage which is larger than the Outline Design by a factor of 2-3 is required to obtain the same controllability in the elongated version. (author)

  4. Results of ITER/EDA and Japan's approach in the prolonged research period

    International Nuclear Information System (INIS)

    Tsunematsu, Toshihide

    1998-01-01

    The Engineering and Design Activity (EDA) of the International Thermonuclear Experimental Reactor (ITER) started operation with the cooperation of Japan, EU, Russia and the US in July 1992 with a plan to do work on the design of the ITER and necessary R and D. Six years passed and the final report was completed in February 1998, reporting that the initial targets were almost achieved except for design work depending on construction site. It was also decided to prolong the EDA for more three years, though the US did not participate. The new EDA items include: Design to meet site requirements and cost estimation; preparation for application for construction approval; and preparation of technical documents for equipment procurement in the future. Among them, the main EDA item is to design a low-cost ITER to be ready for construction when the three-year joint research is ended. For this, work was done to prepare technical guidelines. The EDA is now making the conceptual design of a new ITER 50% less expensive than the current ITER described in the final design report. Japan has proposed site requirements that are needed for design alteration when the ITER is constructed in Japan. The site requirements are concerned with earthquake resistance, ground, power supply and cooling conditions. (N.H.)

  5. Methylation state of the EDA gene promoter in Chinese X-linked hypohidrotic ectodermal dysplasia carriers.

    Directory of Open Access Journals (Sweden)

    Wei Yin

    Full Text Available Hypodontia, hypohidrosis, sparse hair and characteristic faces are the main characters of X-linked hypohidrotic ectodermal dysplasia (XLHED which is caused by genetic ectodysplasin A (EDA deficiency. Heterozygous female carriers tend to have mild to moderate XLHED phenotype, even though 30% of them present no obvious symptom.A large Chinese XLHED family was reported and the entire coding region and exon-intron boundaries of EDA gene were sequenced. To elucidate the mechanism for carriers' tempered phenotype, we analyzed the methylation level on four sites of the promoter of EDA by the pyrosequencing system.A known frameshift mutation (c.573-574 insT was found in this pedigree. Combined with the pedigrees we reported before, 120 samples comprised of 23 carrier females from 11 families and 97 healthy females were analyzed for the methylation state of EDA promoter. Within 95% confidence interval (CI, 18 (78.26% carriers were hypermethylated at these 4 sites.Chinese XLHED carriers often have a hypermethylated EDA promoter.

  6. Assessment of the hemodynamic changes after EDAS combined with bifrontal EGS in pediatric patients with moyamoya disease

    Energy Technology Data Exchange (ETDEWEB)

    Song, Yoo Sung; Kim, Yu Kyeong; Lee, Jae Sung; Kim, Seung Ki; Lee, Dong Soo; Chung, June Key; Lee, Myung Chul [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    To assess the effect of encephaloduroarteriosynangiosis (EDAS) with or without bifrontal encephalogaleosynangiosis (EGS) in children with moyamoya disease, we evaluated cerebral hemodynamic changes using brain Tc-99m HMPAO SPECT. Total 34 pediatric patients (M: F=12:22, mean age;93 yrs) enrolled. Bypass surgery for both hemispheres (EDAS with EGS on one side, and EDAS on the other side) in 25 patients, unilateral EDAS with EGS in 7, and unilateral EDAS only in 2 were underwent. Perfusion SPECT before surgery, and 4 to 18 months after final surgery were done. The vascular territories for ICA, MCA and the brain regions for the frontal, parietal, temporal, and the occipital cortices were determined using standard ROls based on K-SPAM. Additionally, medial frontal cortex was selected to assess the effect of EGS. Basal/acetazolamide challenged cerebral blood flow (CBF), and cerebral vascular index (CVRI) were determined using normalized regional brain uptake to the cerebellum. 24 patients became symptom free, and 6 were improved but having some residual symptoms at the last follow up period. The other 3 were worsened after operation. Overall basal/acetazolamide stress CBF and CVRI for each brain region after surgery were increased, however, only the changes of CVRI were significant. Meanwhile, the improvement of CBF or CVRI in the brain regions ipsilateral to the hemisphere having EDAS with EGS was not significantly different when compared with those for the brain regions with EDAS only. Also, the hemodynamic improvement for the mesial frontal cortex in patients after EDAS with EGS was not significant, and showed no difference with those in patient with EDAS only. Quantitative perfusion SPECT demonstrated the hemodynamic improvement after EDAS with or without EGS in pediatric moyamoya disease. Cerebrovascular reserve showed meaningful improvement after surgery, implicating the effect of vascular anastomosis in ischemic areas.

  7. Assessment of the hemodynamic changes after EDAS combined with bifrontal EGS in pediatric patients with moyamoya disease

    International Nuclear Information System (INIS)

    Song, Yoo Sung; Kim, Yu Kyeong; Lee, Jae Sung; Kim, Seung Ki; Lee, Dong Soo; Chung, June Key; Lee, Myung Chul

    2007-01-01

    To assess the effect of encephaloduroarteriosynangiosis (EDAS) with or without bifrontal encephalogaleosynangiosis (EGS) in children with moyamoya disease, we evaluated cerebral hemodynamic changes using brain Tc-99m HMPAO SPECT. Total 34 pediatric patients (M: F=12:22, mean age;93 yrs) enrolled. Bypass surgery for both hemispheres (EDAS with EGS on one side, and EDAS on the other side) in 25 patients, unilateral EDAS with EGS in 7, and unilateral EDAS only in 2 were underwent. Perfusion SPECT before surgery, and 4 to 18 months after final surgery were done. The vascular territories for ICA, MCA and the brain regions for the frontal, parietal, temporal, and the occipital cortices were determined using standard ROls based on K-SPAM. Additionally, medial frontal cortex was selected to assess the effect of EGS. Basal/acetazolamide challenged cerebral blood flow (CBF), and cerebral vascular index (CVRI) were determined using normalized regional brain uptake to the cerebellum. 24 patients became symptom free, and 6 were improved but having some residual symptoms at the last follow up period. The other 3 were worsened after operation. Overall basal/acetazolamide stress CBF and CVRI for each brain region after surgery were increased, however, only the changes of CVRI were significant. Meanwhile, the improvement of CBF or CVRI in the brain regions ipsilateral to the hemisphere having EDAS with EGS was not significantly different when compared with those for the brain regions with EDAS only. Also, the hemodynamic improvement for the mesial frontal cortex in patients after EDAS with EGS was not significant, and showed no difference with those in patient with EDAS only. Quantitative perfusion SPECT demonstrated the hemodynamic improvement after EDAS with or without EGS in pediatric moyamoya disease. Cerebrovascular reserve showed meaningful improvement after surgery, implicating the effect of vascular anastomosis in ischemic areas

  8. Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice

    Czech Academy of Sciences Publication Activity Database

    Kristenová, Pavlína; Peterka, Miroslav; Lisi, S.; Gendrault, J. L.; Lesot, H.; Peterková, Renata

    2002-01-01

    Roč. 5, - (2002), s. 205-214 ISSN 1397-5927 R&D Projects: GA AV ČR IAA7039901; GA MŠk OC B8.10; GA ČR GA304/02/0448 Institutional research plan: CEZ:AV0Z5039906 Keywords : breeding * ectodermal dysplasia * EDA Subject RIV: EA - Cell Biology

  9. A novel missense mutation in collagenous domain of EDA gene in a ...

    Indian Academy of Sciences (India)

    2Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an,. Shaanxi 710061 .... The mutation p.P220L of EDA responsible for XLHED affects the evolu- tionarily highly .... for University Students (no.

  10. A novel missense mutation in collagenous domain of EDA gene in a ...

    Indian Academy of Sciences (India)

    Supplementary data: A novel missense mutation in collagenous domain of EDA gene in a. Chinese family with X-linked hypohidrotic ectodermal dysplasia. Daxu Li, Ran Xu, Fumeng Huang, Biyuan Wang, Yu Tao, Zijian Jiang, Hairui Li, Jianfeng Yao,. Peng Xu, Xiaokang Wu, Le Ren, Rui Zhang, John R. Kelsoe and Jie Ma.

  11. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates.

    Directory of Open Access Journals (Sweden)

    Matthew P Harris

    2008-10-01

    Full Text Available The genetic basis of the development and variation of adult form of vertebrates is not well understood. To address this problem, we performed a mutant screen to identify genes essential for the formation of adult skeletal structures of the zebrafish. Here, we describe the phenotypic and molecular characterization of a set of mutants showing loss of adult structures of the dermal skeleton, such as the rays of the fins and the scales, as well as the pharyngeal teeth. The mutations represent adult-viable, loss of function alleles in the ectodysplasin (eda and ectodysplasin receptor (edar genes. These genes are frequently mutated in the human hereditary disease hypohidrotic ectodermal dysplasia (HED; OMIM 224900, 305100 that affects the development of integumentary appendages such as hair and teeth. We find mutations in zebrafish edar that affect similar residues as mutated in human cases of HED and show similar phenotypic consequences. eda and edar are not required for early zebrafish development, but are rather specific for the development of adult skeletal and dental structures. We find that the defects of the fins and scales are due to the role of Eda signaling in organizing epidermal cells into discrete signaling centers of the scale epidermal placode and fin fold. Our genetic analysis demonstrates dose-sensitive and organ-specific response to alteration in levels of Eda signaling. In addition, we show substantial buffering of the effect of loss of edar function in different genetic backgrounds, suggesting canalization of this developmental system. We uncover a previously unknown role of Eda signaling in teleosts and show conservation of the developmental mechanisms involved in the formation and variation of both integumentary appendages and limbs. Lastly, our findings point to the utility of adult genetic screens in the zebrafish in identifying essential developmental processes involved in human disease and in morphological evolution.

  12. Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates

    Science.gov (United States)

    Harris, Matthew P.; Rohner, Nicolas; Schwarz, Heinz; Perathoner, Simon; Konstantinidis, Peter; Nüsslein-Volhard, Christiane

    2008-01-01

    The genetic basis of the development and variation of adult form of vertebrates is not well understood. To address this problem, we performed a mutant screen to identify genes essential for the formation of adult skeletal structures of the zebrafish. Here, we describe the phenotypic and molecular characterization of a set of mutants showing loss of adult structures of the dermal skeleton, such as the rays of the fins and the scales, as well as the pharyngeal teeth. The mutations represent adult-viable, loss of function alleles in the ectodysplasin (eda) and ectodysplasin receptor (edar) genes. These genes are frequently mutated in the human hereditary disease hypohidrotic ectodermal dysplasia (HED; OMIM 224900, 305100) that affects the development of integumentary appendages such as hair and teeth. We find mutations in zebrafish edar that affect similar residues as mutated in human cases of HED and show similar phenotypic consequences. eda and edar are not required for early zebrafish development, but are rather specific for the development of adult skeletal and dental structures. We find that the defects of the fins and scales are due to the role of Eda signaling in organizing epidermal cells into discrete signaling centers of the scale epidermal placode and fin fold. Our genetic analysis demonstrates dose-sensitive and organ-specific response to alteration in levels of Eda signaling. In addition, we show substantial buffering of the effect of loss of edar function in different genetic backgrounds, suggesting canalization of this developmental system. We uncover a previously unknown role of Eda signaling in teleosts and show conservation of the developmental mechanisms involved in the formation and variation of both integumentary appendages and limbs. Lastly, our findings point to the utility of adult genetic screens in the zebrafish in identifying essential developmental processes involved in human disease and in morphological evolution. PMID:18833299

  13. Final report of the ITER EDA. Final report of the ITER Engineering Design Activities. Prepared by the ITER Council

    International Nuclear Information System (INIS)

    2001-01-01

    This is the Final Report by the ITER Council on work carried out by ITER participating countries on cooperation in the Engineering Design Activities (EDA) for the ITER. In this report the main ITER EDA technical objectives, the scope of ITER EDA, its organization and resources, engineering design of ITER tokamak and its main parameters are presented. This Report also includes safety and environmental assessments, site requirements and proposed schedule and estimates of manpower and cost as well as proposals on approaches to joint implementation of the project

  14. EDA mutation as a cause of hypohidrotic ectodermal dysplasia: a case report and review of the literature.

    Science.gov (United States)

    Huang, S X; Liang, J L; Sui, W G; Lin, H; Xue, W; Chen, J J; Zhang, Y; Gong, W W; Dai, Y; Ou, M L

    2015-08-28

    Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure of development of the tissues derived from the embryonic ectoderm. ED is often associated with hair, teeth, and skin abnormalities, which are serious conditions affecting the quality of life of the patient. To date, a large number of genes have been found to be associated with this syndrome. Here, we report a patient with hypohidrotic ED (HED) without family history. We identified that this patient's disorder arises from an X-linked HED with a mutation in the EDA gene (G299D) found by whole-exome sequencing. In addition, in this paper we summarize the disease-causing mutations based on current literature. Overall, recent clinical and genetic research involving patients with HED have uncovered a large number of pathogenic mutations in EDA, which might contribute to a full understanding of the function of EDA and the underlying mechanisms of HED caused by EDA mutations.

  15. Kommunikatsioonijuht saab aidata arsti ja patsienti / Eda Amur, Anneli Bogens, Svea Talving, Krista Valdvee ; intervjueerinud Küllike Heide

    Index Scriptorium Estoniae

    2013-01-01

    Meditsiinivaldkonna kommunikatsiooniga seotud küsimuste ja probleemide üle arutlevad nelja haigla kommunikatsioonijuhid: Eda Amur Pärnu haiglast, Anneli Bogens Ida-Viru keskhaiglast, Svea Talving Ida-Tallinna keskhaiglast ning Krista Valdvee Viljandi haiglast

  16. 75 FR 32911 - Notice of Informational Meeting for the i6 Challenge Under EDA's Economic Adjustment Assistance...

    Science.gov (United States)

    2010-06-10

    ... new, multi-agency innovation competition led by the Economic Development Administration (EDA), a... are in need of additional support, in order to strengthen regional innovation ecosystems. Applicants... DEPARTMENT OF COMMERCE Economic Development Administration Notice of Informational Meeting for the...

  17. A technical evaluation of the EDA radon gas continuous monitoring system

    International Nuclear Information System (INIS)

    Bigu, J.

    1979-04-01

    Extensive laboratory and underground tests were conducted with a radon gas continuous monitoring system built by EDA Instruments Inc. The system consists of several remote radon gas sensors linked via signal cables to a central control unit that fully controls the operation of the radon monitors. The system enables four operations to be performed: sampling, background, flush and bypass. The sequence and duration of these functions is programmable. Up to 20 functions in any desired pattern each lasting from 1 min to 23 hr 59 min can be programmed. Several programs were used during the experiments in order to obtain radon and thoron gas levels. The performance of the EDA system was quite satisfactory. It is suggested that ruggedization as well as some other modifications be introdouced into the system to: a) better withstand the harsh underground environment; and b) improve its performance

  18. A Splice Defect in the EDA Gene in Dogs with an X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Phenotype.

    Science.gov (United States)

    Waluk, Dominik P; Zur, Gila; Kaufmann, Ronnie; Welle, Monika M; Jagannathan, Vidhya; Drögemüller, Cord; Müller, Eliane J; Leeb, Tosso; Galichet, Arnaud

    2016-09-08

    X-linked hypohidrotic ectodermal dysplasia (XLHED) caused by variants in the EDA gene represents the most common ectodermal dysplasia in humans. We investigated three male mixed-breed dogs with an ectodermal dysplasia phenotype characterized by marked hypotrichosis and multifocal complete alopecia, almost complete absence of sweat and sebaceous glands, and altered dentition with missing and abnormally shaped teeth. Analysis of SNP chip genotypes and whole genome sequence data from the three affected dogs revealed that the affected dogs shared the same haplotype on a large segment of the X-chromosome, including the EDA gene. Unexpectedly, the whole genome sequence data did not reveal any nonsynonymous EDA variant in the affected dogs. We therefore performed an RNA-seq experiment on skin biopsies to search for changes in the transcriptome. This analysis revealed that the EDA transcript in the affected dogs lacked 103 nucleotides encoded by exon 2. We speculate that this exon skipping is caused by a genetic variant located in one of the large introns flanking this exon, which was missed by whole genome sequencing with the illumina short read technology. The altered EDA transcript splicing most likely causes the observed ectodermal dysplasia in the affected dogs. These dogs thus offer an excellent opportunity to gain insights into the complex splicing processes required for expression of the EDA gene, and other genes with large introns. Copyright © 2016 Waluk et al.

  19. EDAS: An Evaluation Prototype for Autonomic Event-Driven Adaptive Security in the Internet of Things

    Directory of Open Access Journals (Sweden)

    Waqas Aman

    2015-07-01

    Full Text Available In Internet of Things (IoT, the main driving technologies are considered to be tiny sensory objects. These objects cannot host traditional preventive and detective technologies to provide protection against the increasing threat sophistication. Furthermore, these solutions are limited to analyzing particular contextual information, for instance network information or files, and do not provide holistic context for risk analysis and response. Analyzing a part of a situation may lead to false alarms and later to unnecessary and incorrect configurations. To overcome these concerns, we proposed an event-driven adaptive security (EDAS model for IoT. EDAS aims to observe security events (changes generated by various things in the monitored IoT environment, investigates any intentional or unintentional risks associated with the events and adapts to it autonomously. It correlates different events in time and space to reduce any false alarms and provides a mechanism to predict attacks before they are realized. Risks are responded to autonomically by utilizing a runtime adaptation ontology. The mitigation action is chosen after assessing essential information, such as the risk faced, user preferences, device capabilities and service requirements. Thus, it selects an optimal mitigation action in a particular adverse situation. The objective of this paper is to investigate EDAS feasibility and its aptitude as a real-world prototype in a remote patient monitoring context. It details how EDAS can be a practical choice for IoT-eHealth in terms of the security, design and implementation features it offers as compared to traditional security controls. We have explained the prototype’s major components and have highlighted the key technical challenges.

  20. ITER EDA newsletter. V. 3, no. 1. (International Thermonuclear Experimental Reactor Engineering Design Activities)

    International Nuclear Information System (INIS)

    1994-01-01

    This issues of the ITER EDA (Engineering Design Activities) Newsletter contains reports on the Fourth ITER Management Advisory Committee Meeting (MAC) held at San Diego, USA, 13-14 January, 1994, a Technical Committee Meeting on Plasma Equilibrium and Control held at Naka, Japan, 9-12 November 1993, and a Technical Committee Meeting on Radio-Frequency Heating and Current Drive held in Garching, Germany, 21-26 October 1993

  1. EDA-BASED ESTIMATION OF VISUAL ATTENTION BY OBSERVATION OF EYE BLINK FREQUENCY

    OpenAIRE

    Sakai, Tsugunosuke; Tamaki, Haruya; Ota, Yosuke; Egusa, Ryohei; Inagaki, Shigenori; Kusunoki, Fusako; Sugimoto, Masanori; Mizoguchi, Hiroshi

    2017-01-01

    This paper describes the relationship between visual attention and eye blink frequency. In an experiment, we prompted the activation of a subject's visual attention and examined the influence of visual attention (as measured using electrodermal activity (EDA), which is meaningfully correlated with visual attention) on the subject's eye blink frequency. Experimental results show that engagement of visual attention decreased eye blink frequency and that when visual attention was not activated, ...

  2. Päevaleht kasvatab tellijate arvu tasa ja targu / Aavo Kokk ; interv. Eda-Liis Kann

    Index Scriptorium Estoniae

    Kokk, Aavo, 1964-

    2005-01-01

    2004. aasta ajalehtede TOP-is esikoha võitnud Eesti Päevalehe peadirektor vastab küsimustele, mis puudutavad ajalehe tiraazhi, müügistrateegiat, reklaamikäivet, reklaami müümist esikaanel ja konkurentsi ajalehega Postimees. Vt. samas: Eda-Liis Kann. Ajalehed prognoosivad reklaamikasvu. Kommenteerib OÜ Türi Rahvaleht peatoimetaja Olev Kenk. Tabel: Ajalehtede TOP 15

  3. Novel EDA mutation in X-linked hypohidrotic ectodermal dysplasia and genotype-phenotype correlation.

    Science.gov (United States)

    Zeng, B; Lu, H; Xiao, X; Zhou, L; Lu, J; Zhu, L; Yu, D; Zhao, W

    2015-11-01

    X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormalities of hair, teeth, and sweat glands, while non-syndromic hypodontia (NSH) affects only teeth. Mutations in Ectodysplasin A (EDA) underlie both XLHED and NSH. This study investigated the genetic causes of six hypohidrotic ectodermal dysplasia (HED) patients and genotype-phenotype correlation. The EDA gene of six patients with HED was sequenced. Bioinformatics analysis and structural modeling for the mutations were performed. The records of 134 patients with XLHED and EDA-related NSH regarding numbers of missing permanent teeth from this study and 20 articles were reviewed. Nonparametric tests were used to analyze genotype-phenotype correlations. In four of the six patients, we identified a novel mutation c.852T>G (p.Phe284Leu) and three reported mutations: c.467G>A (p.Arg156His), c.776C>A (p.Ala259Glu), and c.871G>A (p.Gly291Arg). They were predicted to be pathogenic by bioinformatics analysis and structural modeling. Genotype-phenotype correlation analysis revealed that truncating mutations were associated with more missing teeth. Missense mutations and the mutations affecting the TNF homology domain were correlated with fewer missing teeth. This study extended the mutation spectrum of XLHED and revealed the relationship between genotype and the number of missing permanent teeth. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Effects of negative pressure wound therapy on the expression of EDA+ FN in granulation tissues of human diabetic foot wounds

    Directory of Open Access Journals (Sweden)

    Shao-ling YANG

    2017-04-01

    Full Text Available Objective  To investigate the effects of negative pressure wound therapy (NPWT on the expression of EDA+ FN in granulation tissues of human diabetic foot wounds. Methods  Forty patients with diabetic foot wounds fitting the inclusion criteria, admitted from Jan. 2014 to Jun. 2016, were randomly and equally apportioned to receive either NPWT or conventional gauze therapy (control for 14 days. Granulated tissue biopsies were collected before (0 day and after (14 day treatment in both groups. All biopsies were subdivided into two parts. One part was preserved in 4% paraformaldehyde for immunocytochemical staining of EDA+ FN, and the other part was stored at –80℃for Western blotting and PCR analysis of EDA+ FN. Results  The immunohistochemical analysis revealed that the mean area density of EDA+ FN increased in both NPWT group and control group at day 14 relative to day 0, but the change value of mean area density was higher in NPWT group than in control group (P<0.01. Western blotting showed that the relative protein levels of EDA+ FN increased in both NPWT group and control group at day 14 relative to day 0, but the change value of relative protein levels of EDA+ FN was higher in NPWT group than in control group (P<0.01. The real time PCR analysis demonstrated that the relative mRNA levels of EDA+ FN increased in both NPWT group and control group at day 14 relative to day 0, but the change value of relative mRNA levels of EDA+ FN was higher in NPWT group than in control group (P<0.01. The results demonstrated the higher protein and mRNA levels of EDA+ FN in NPWT group than that in control group. Conclusion  NPWT obviously enhances EDA+ FN expression in granulation tissue of diabetic foot wound, as a result promotes wound healing. DOI: 10.11855/j.issn.0577-7402.2017.03.09

  5. The Eating Disorder Assessment for DSM-5 (EDA-5): Development and Validation of a Structured Interview for Feeding and Eating Disorders

    Science.gov (United States)

    Sysko, Robyn; Glasofer, Deborah R.; Hildebrandt, Tom; Klimek, Patrycja; Mitchell, James E.; Berg, Kelly C.; Peterson, Carol B.; Wonderlich, Stephen A.; Walsh, B. Timothy

    2016-01-01

    Objective Existing measures for DSM-IV eating disorder diagnoses have notable limitations, and there are important differences between DSM-IV and DSM-5 feeding and eating disorders. This study developed and validated a new semi-structured interview, the Eating Disorders Assessment for DSM-5 (EDA-5). Method Two studies evaluated the utility of the EDA-5. Study 1 compared the diagnostic validity of the EDA-5 to the Eating Disorder Examination (EDE) and evaluated the test-retest reliability of the new measure. Study 2 compared the diagnostic validity of an EDA-5 electronic application (“app”) to clinician interview and self-report assessments. Results In Study 1, the kappa for EDE and EDA-5 eating disorder diagnoses was 0.74 across all diagnoses (n= 64), with a range of κ=0.65 for Other Specified Feeding or Eating Disorder (OSFED)/Unspecified Feeding or Eating Disorder (USFED) to κ=0.90 for Binge Eating Disorder (BED). The EDA-5 test-retest kappa coefficient was 0.87 across diagnoses. For Study 2, clinical interview versus “app” conditions revealed a kappa of 0.83 for all eating disorder diagnoses (n=71). Across individual diagnostic categories, kappas ranged from 0.56 for OSFED/USFED to 0.94 for BN. Discussion High rates of agreement were found between diagnoses by EDA-5 and the EDE, and EDA-5 and clinical interviews. As this study supports the validity of the EDA-5 to generate DSM-5 eating disorders and the reliability of these diagnoses, the EDA-5 may be an option for the assessment of Anorexia Nervosa, Bulimia Nervosa, and BED. Additional research is needed to evaluate the utility of the EDA-5 in assessing DSM-5 feeding disorders. PMID:25639562

  6. Balti projekteerimisbüroode 6 suurimat murelast / Eva Tammelo

    Index Scriptorium Estoniae

    Tammelo, Eva

    2006-01-01

    Ilmunud ka: Stroitel, 2006, nr. 1, lk. 10-14. Elina Kuzjukevica ja Aleksejs Nipersi (Rode & Weiland Ltd.) Phare programmi kuuluvast uurimusest "Balti projektbüroode koostöövõrk: Sektori efektiivsuse tõstmine ja arendamine". Siseturu ja välisturgude SWOT-analüüs

  7. Structure and dynamics of a complex of cellulose with EDA: insights into the action of amines on cellulose

    Energy Technology Data Exchange (ETDEWEB)

    Sawada, Daisuke [ORNL; Nishiyama, Yoshiharu [Centre de Recherches sur les Macromolecules Vegetales (CERMAV-CNRS); Petridis, Loukas [ORNL; Parthasarathi, R. [Los Alamos National Laboratory (LANL); Gnanakaran, S [Los Alamos National Laboratory (LANL); Forsyth, V. T. [Institut Laue Langevin and Keele University; Wada, Masahisa [University of Tokyo, Japan; Langan, Paul [ORNL

    2013-01-01

    The neutron structure of a complex of EDA with cellulose has been determined to reveal the location of hydrogen atoms involved in hydrogen bonding. EDA disrupts the hydrogen bonding pattern of naturally occurring cellulose by accepting a strong hydrogen bond from the O6 hydroxymethyl group as the conformation of this group is rotated from tg to gt. The O3-H O5 intrachain hydrogen bond commonly found in cellulose allomorphs is observed to be disordered in the neutron structure, and quantum chemistry and molecular dynamics calculations show that O3 prefers to donate to EDA. The hydrogen bonding arrangement is highly dynamic with bonds continually being formed and broken thus explaining the difficulty in locating all of the hydrogen atoms in the neutron scattering density maps. Comparison with other polysaccharide-amine complexes supports a common underlying mechanism for amine disruption of cellulose.

  8. VDE characteristics during disruption process and its underlying acceleration mechanism in the ITER-EDA tokamak

    International Nuclear Information System (INIS)

    Nakamura, Yukiharu; Nishio, Satoshi; Yoshino, Ryuji; Kessel, C.E.; Jardin, S.C.

    1996-01-01

    The dynamic behavior of vertical displacement events (VDEs) during a disruption and acceleration mechanisms that govern VDEs in the ITER-EDA tokamak are investigated using the Tokamak Simulation Code. A sudden plasma pressure drop (β p collapse) does not accelerate VDEs for the ITER tokamak. The geometry of the ITER resistive shell is shown to be suitable for preventing a β p collapse-induced VDE, because the magnetic field decay n-index after the β p collapse does not considerably degrade. On the other hand, it is shown that the plasma current quench (I p quench) following the energy quench can accelerate VDEs due to the vertical imbalance of the attractive force arising from the up-down asymmetric shell. The vertical location of the neutral point where the I p quench-induced VDE almost disappears is found to lie at ∼22 cm below the plasma magnetic axis of the nominal equilibrium (Z = 1.44 m). An upward and moderate I p quench-induced VDE can be expected for the nominal configuration in the ITER-EDA tokamak. It is shown that the ITER tokamak has an advantage of avoiding the fatal damage of the complicated structures of the bottom-divertor. (author)

  9. A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

    Science.gov (United States)

    Xiao, Ying; Thoresen, Daniel T; Miao, Lingling; Williams, Jonathan S; Wang, Chaochen; Atit, Radhika P; Wong, Sunny Y; Brownell, Isaac

    2016-07-01

    The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in tandem with primary hair follicles and contain sensory Merkel cells. The developmental signaling requirements for touch dome specification are largely unknown. We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles. Lineage-specific gene deletions revealed intraepithelial Shh signaling was necessary for Merkel cell specification. Additionally, a Shh signaling agonist was sufficient to rescue Merkel cell differentiation in Edar-deficient skin. Moreover, Merkel cells formed in Fgf20 mutant skin where primary hair formation was defective but Shh production was preserved. Although developmentally associated with hair follicles, fate mapping demonstrated Merkel cells primarily originated outside the hair follicle lineage. These findings suggest that touch dome development requires Wnt-dependent mesenchymal signals to establish reciprocal signaling within the developing ectoderm, including Eda signaling to primary hair placodes and ultimately Shh signaling from primary follicles to extrafollicular Merkel cell progenitors. Shh signaling often demonstrates pleiotropic effects within a structure over time. In postnatal skin, Shh is known to regulate the self-renewal, but not the differentiation, of touch dome stem cells. Our findings relate the varied effects of Shh in the touch dome to the ligand source, with locally produced Shh acting as a morphogen essential for lineage specification during development and neural Shh regulating postnatal touch dome stem cell maintenance.

  10. A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

    Directory of Open Access Journals (Sweden)

    Ying Xiao

    2016-07-01

    Full Text Available The Sonic hedgehog (Shh signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in tandem with primary hair follicles and contain sensory Merkel cells. The developmental signaling requirements for touch dome specification are largely unknown. We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles. Lineage-specific gene deletions revealed intraepithelial Shh signaling was necessary for Merkel cell specification. Additionally, a Shh signaling agonist was sufficient to rescue Merkel cell differentiation in Edar-deficient skin. Moreover, Merkel cells formed in Fgf20 mutant skin where primary hair formation was defective but Shh production was preserved. Although developmentally associated with hair follicles, fate mapping demonstrated Merkel cells primarily originated outside the hair follicle lineage. These findings suggest that touch dome development requires Wnt-dependent mesenchymal signals to establish reciprocal signaling within the developing ectoderm, including Eda signaling to primary hair placodes and ultimately Shh signaling from primary follicles to extrafollicular Merkel cell progenitors. Shh signaling often demonstrates pleiotropic effects within a structure over time. In postnatal skin, Shh is known to regulate the self-renewal, but not the differentiation, of touch dome stem cells. Our findings relate the varied effects of Shh in the touch dome to the ligand source, with locally produced Shh acting as a morphogen essential for lineage specification during development and neural Shh regulating postnatal touch dome stem cell maintenance.

  11. Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients.

    Science.gov (United States)

    Zeng, Binghui; Xiao, Xue; Li, Sijie; Lu, Hui; Lu, Jiaxuan; Zhu, Ling; Yu, Dongsheng; Zhao, Wei

    2016-09-19

    Hypohidrotic ectodermal dysplasia (HED) is characterized by abnormal development of the teeth, hair, and sweat glands. Ectodysplasin A (EDA), Ectodysplasin A receptor (EDAR), and EDAR-associated death domain (EDARADD) are candidate genes for HED, but the relationship between WNT10A and HED has not yet been validated. In this study, we included patients who presented at least two of the three ectodermal dysplasia features. The four genes were analyzed in seven HED patients by PCR and Sanger sequencing. Five EDA and one EDAR heterozygous mutations were identified in families 1-6. Two WNT10A heterozygous mutations were identified in family 7 as a compound heterozygote. c.662G>A (p.Gly221Asp) in EDA and c.354T>G (p.Tyr118*) in WNT10A are novel mutations. Bioinformatics analyses results confirmed the pathogenicity of the two novel mutations. In family 7, we also identified two single-nucleotide polymorphisms (SNPs) that were predicted to affect the splicing of EDAR. Analysis of the patient's total RNA revealed normal splicing of EDAR. This ascertained that the compound heterozygous WNT10A mutations are the genetic defects that led to the onset of HED. Our data revealed the genetic basis of seven HED patients and expended the mutational spectrum. Interestingly, we confirmed WNT10A as a candidate gene of HED and we propose WNT10A to be tested in EDA-negative HED patients.

  12. Fine mapping of the EDA gene: A translocation breakpoint is associated with a CpG island that is transcribed

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, A.K.; Schlessinger, D. [Washington Univ. School of Medicine, St. Louis, MO (United States); Montonen, O. [Univ. of Helsinki (Finland)] [and others

    1996-01-01

    In order to identify the gene for human X-linked anhidrotic ectodermal dysplasia (EDA), a translocation breakpoint in a female with t(X;1)(q13.1;p36.3) and EDA (patient AK) was finely mapped. The EDA region contains five groups of rare-cutter restriction sites that define CpG islands. The two more centromeric of these islands are associated with transcripts of 3.5 kb and 1.8 kb. The third CpG island maps within <1 kb of the translocation breakpoint in patient AK, as indicated by a genomic rearrangement, and {approximately}100 kb centromeric from another previously mapped translocation breakpoint (patient AnLy). Northern analysis with a probe from this CpG island detected an {approximately}6-kb mRNA in several fetal tissues tested. An extended YAC contig of 1,200 kb with an average of fivefold coverage was constructed. The two most telomeric CpG islands map 350 kb telomeric of the two translocations. Taken together, the results suggest that the CpG island just proximal of the AK translocation breakpoint lies at the 5{prime} end of a candidate gene for EDA. 26 refs., 4 figs., 1 tab.

  13. Design and Investigation of Optical Properties of N-(Rhodamine-B)-Lactam-Ethylenediamine (RhB-EDA) Fluorescent Probe.

    Science.gov (United States)

    Soršak, Eva; Volmajer Valh, Julija; Korent Urek, Špela; Lobnik, Aleksandra

    2018-04-14

    This study presents chemical modification of a Rhodamine B (RhB) sensor probe by ethylenediamine (EDA), and investigation of its spectral as well as sensor properties to the various metals. The synthesised N -(Rhodamine-B)-lactam-ethylenediamine (RhB-EDA) fluorescent probe shows interesting optical sensor properties, and high sensitivity and selectivity to Ag⁺ ions among all the tested metal ions (K⁺, Mg 2+ , Cu 2+ , Ni 2+ , Fe 2+ , Pb 2+ , Na⁺, Mn 2+ , Li⁺, Al 3+ , Co 2+ , Hg 2+ , Sr 2+ , Ca 2+ , Ag⁺, Cd 2+ and Zn 2+ ), while the well-known Rhodamine B (RhB) fluorescent probe shows much less sensitivity to Ag⁺ ions, but high sensitivity to Fe 2+ ions. The novel fluorescent sensor probe RhB-EDA has the capabilities to sense Ag⁺ ions up to µM ranges by using the fluorescence quenching approach. The probe displayed a dynamic response to Ag⁺ in the range of 0.43 × 10 -3 -10 -6 M with a detection limit of 0.1 μM. The sensing system of an RhB-EDA novel fluorescent probe was optimised according to the spectral properties, effect of pH and buffer, photostability, incubation time, sensitivity, and selectivity. Since all the spectral and sensing properties were tested in green aqueous media, although many other similar sensor systems rely on organic solvent solutions, the RhB-EDA sensing probe may be a good candidate for measuring Ag⁺ ions in real-life applications.

  14. Energy Design Advice Scheme (EDAS): operations and achievements 1992-1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The Energy Design Advice Scheme (EDAS) was launched in 1992 under the DTI's Passive Solar Programme to help improve the energy performance of the UK's building stock. It aimed to do this through direct advice and guidance on passive solar design and energy efficient technologies and processes given to the designers of real building projects. Furthermore, the scheme aimed to raise the awareness and take-up of definitive guidance produced under government programmes such as the Passive Solar programme and the Energy Efficiency Best Practice programme. A target energy saving worth Pound 19.3m was set to be achieved by the end of the scheme. This energy saving is equivalent to a reduction in carbon dioxide emission of 220,000 tonnes per year. (author)

  15. Development of environmental dose assessment system (EDAS) code of PC version

    CERN Document Server

    Taki, M; Kobayashi, H; Yamaguchi, T

    2003-01-01

    A computer code (EDAS) was developed to assess the public dose for the safety assessment to get the license of nuclear reactor operation. This code system is used for the safety analysis of public around the nuclear reactor in normal operation and severe accident. This code was revised and composed for personal computer user according to the Nuclear Safety Guidelines reflected the ICRP1990 recommendation. These guidelines are revised by Nuclear Safety Commission on March, 2001, which are 'Weather analysis guideline for the safety assessment of nuclear power reactor', 'Public dose around the facility assessment guideline corresponding to the objective value for nuclear power light water reactor' and 'Public dose assessment guideline for safety review of nuclear power light water reactor'. This code has been already opened for public user by JAERI, and English version code and user manual are also prepared. This English version code is helpful for international cooperation concerning the nuclear safety assessme...

  16. Energy Design Advice Scheme (EDAS): operations and achievements 1992-1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The Energy Design Advice Scheme (EDAS) was launched in 1992 under the DTI's Passive Solar Programme to help improve the energy performance of the UK's building stock. It aimed to do this through direct advice and guidance on passive solar design and energy efficient technologies and processes given to the designers of real building projects. Furthermore, the scheme aimed to raise the awareness and take-up of definitive guidance produced under government programmes such as the Passive Solar programme and the Energy Efficiency Best Practice programme. A target energy saving worth Pound 19.3m was set to be achieved by the end of the scheme. This energy saving is equivalent to a reduction in carbon dioxide emission of 220,000 tonnes per year. (author)

  17. How the new optoelectronic design automation industry is taking advantage of preexisting EDA standards

    Science.gov (United States)

    Nesmith, Kevin A.; Carver, Susan

    2014-05-01

    With the advancements in design processes down to the sub 7nm levels, the Electronic Design Automation industry appears to be coming to an end of advancements, as the size of the silicon atom becomes the limiting factor. Or is it? The commercial viability of mass-producing silicon photonics is bringing about the Optoelectronic Design Automation (OEDA) industry. With the science of photonics in its infancy, adding these circuits to ever-increasing complex electronic designs, will allow for new generations of advancements. Learning from the past 50 years of the EDA industry's mistakes and missed opportunities, the photonics industry is starting with electronic standards and extending them to become photonically aware. Adapting the use of pre-existing standards into this relatively new industry will allow for easier integration into the present infrastructure and faster time to market.

  18. Correlating interleukin-12 stimulated interferon-γ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-κB essential modulator (NEMO).

    Science.gov (United States)

    Haverkamp, Margje H; Marciano, Beatriz E; Frucht, David M; Jain, Ashish; van de Vosse, Esther; Holland, Steven M

    2014-05-01

    Patients with hypomorphic mutations in Nuclear Factor-κB Essential Modulator (NEMO) are immunodeficient (ID) and most display ectodermal dysplasia and anhidrosis (EDA). We compared cytokine production by NEMO-ID patients with and without EDA. PBMCs of NEMO-ID patients, four with EDA carrying E315A, C417R, D311N and Q403X, and three without EDA carrying E315A, E311_L333del and R254G, were cultured with PHA, PHA plus IL-12p70, LPS, LPS plus IFN-γ, TNF and IL-1β. The production of various cytokines was measured in the supernatants. Fifty-nine healthy individuals served as controls. PBMCs of NEMO-ID patients without EDA produce subnormal amounts of IFN-γ after stimulation with PHA, but normal amounts of IFN-γ after PHA plus IL-12p70. In contrast, IFN-γ production by patients with EDA was low in both cases. Patients with EDA also generate lower PHA-stimulated IL-10 and IL-1β than controls, whereas the production of these cytokines by patients without EDA was normal. Responses of PBMCs in NEMO-ID patients with EDA to PHA with and without IL-12p70 appear less robust than in NEMO-ID patients without EDA. This possibly indicates a better preserved NEMO function in our patients without EDA.

  19. Kvaliteedimärk näitab sihikindlust / Vadim Mitroškin, Eda Anton ; küsitlenud Kaidi Holm

    Index Scriptorium Estoniae

    Mitroškin, Vadim

    2006-01-01

    Elukestva Õppe Arendamise Sihtasutuse INNOVE eestvedamisel korraldatud kutsekoolide kvaliteediauhinna konkursist. Küsimustele vastavad Võrumaa Kutsehariduskeskuse kvaliteedidirektor Vadim Mitroškin ja Tartu Kutsehariduskeskuse kvaliteedijuht Eda Anton

  20. [Eda Kalmre. The human sausage factory : a study of post-war rumour in Tartu] / Véronique Vincent-Campion

    Index Scriptorium Estoniae

    Vincent-Campion, Véronique

    2015-01-01

    Arvustus: Kalmre, Eda. The human sausage factory : a study of post-war rumour in Tartu. Amsterdam ; New York : Rodopi, 2013. (On the boundary of two worlds : identity, freedom, and moral imagination in the Baltics, 1570-7121 ; 34)

  1. Pedro de Castañeda: su pintura para el refectorio del Colegio Mayor de San Ildefonso (1553

    Directory of Open Access Journals (Sweden)

    González Ramos, Roberto

    2003-09-01

    Full Text Available El pintor Pedro de Castañeda es un artista poco conocido, activo en la zona de Alcalá de Henares en las décadas centrales del siglo XVI. Se sabe que junto a su hijo Juan fue colaborador del entallador y traductor de Vitruvio Miguel de Urrea. Pedro de Castañeda pintó un cirial que había tallado Urrea para la iglesia parroquial de Camarma de Esteruelas, trabajo por el que ambos cobraron cierta cantidad en 1540, y en 1550 colaboró con ese entallador y con Claudio de Arciniega, ayudado por Juan, en la obra de los retablos colaterales de la iglesia de Daganzo de Arriba (perdidos, realizando su pintura. Parece que se trata del mismo artista el Pedro Castañeda que se documenta trabajando en la zona de Segovia, concretamente en dos retablos para la iglesia de Cascajares del Fresno. Falleció en 1557…

  2. Development of environmental dose assessment system (EDAS) code of PC version

    Energy Technology Data Exchange (ETDEWEB)

    Taki, Mitsumasa; Kikuchi, Masamitsu; Kobayashi, Hideo; Yamaguchi, Takenori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-05-01

    A computer code (EDAS) was developed to assess the public dose for the safety assessment to get the license of nuclear reactor operation. This code system is used for the safety analysis of public around the nuclear reactor in normal operation and severe accident. This code was revised and composed for personal computer user according to the Nuclear Safety Guidelines reflected the ICRP1990 recommendation. These guidelines are revised by Nuclear Safety Commission on March, 2001, which are 'Weather analysis guideline for the safety assessment of nuclear power reactor', 'Public dose around the facility assessment guideline corresponding to the objective value for nuclear power light water reactor' and 'Public dose assessment guideline for safety review of nuclear power light water reactor'. This code has been already opened for public user by JAERI, and English version code and user manual are also prepared. This English version code is helpful for international cooperation concerning the nuclear safety assessment with JAERI. (author)

  3. A Dynamic Fuzzy Approach Based on the EDAS Method for Multi-Criteria Subcontractor Evaluation

    Directory of Open Access Journals (Sweden)

    Mehdi Keshavarz-Ghorabaee

    2018-03-01

    Full Text Available Selection of appropriate subcontractors for outsourcing is very important for the success of construction projects. This can improve the overall quality of projects and promote the qualification and reputation of the main contractors. The evaluation of subcontractors can be made by some experts or decision-makers with respect to some criteria. If this process is done in different time periods, it can be defined as a dynamic multi-criteria group decision-making (MCGDM problem. In this study, we propose a new fuzzy dynamic MCGDM approach based on the EDAS (Evaluation based on Distance from Average Solution method for subcontractor evaluation. In the procedure of the proposed approach, the sets of alternatives, criteria and decision-makers can be changed at different time periods. Also, the proposed approach gives more weight to newer decision information for aggregating the overall performance of alternatives. A numerical example is used to illustrate the proposed approach and show the application of it in subcontractor evaluation. The results demonstrate that the proposed approach is efficient and useful in real-world decision-making problems.

  4. Confinement margins for ignition and driven operation in Iter Eda ID

    International Nuclear Information System (INIS)

    Johner, J.

    1995-09-01

    Preliminary calculations for ITER EDA ID have been performed using the 1/2D thermal equilibrium code HELIOS. It is found that: - The maximum ignition margin for ITER ID (29%) is 6% less than for ITER OD (35%) and 5% less than for ITER CDA (34%). - Decreasing the ration τ * He /τ E from the nominal value 10 to a value of 5 gives a 12% gain in the maximum ignition margin. Increasing the ration from 10 to 15 causes a 22% loss in the margin. Furthermore, ignited equilibria non longer exist for τ * He /τ E ≥ 17.6. - Operation in driven mode with 50 MW of external power increases the confinement capability by 13%. With 100 MW, the improvement is 24%. - Lowering the fusion power from 1500 to 1000 MW slightly improves the maximum ignition margin (+5%) and allows operation below the Greenwald density limit. - A 10% reduction of the toroidal magnetic field with a correlative diminution of the plasma current for constant safety factor operation, causes a dramatic reduction (-18%) of the maximum ignition margin. - A fraction of neon of 0.68% would completely suppress the ignition margin. Furthermore, ignited equilibria, with the nominal fusion power and τ * He /τ E , no longer exist when the neon fraction exceeds 0.75%. (Author). 2 refs., 10 figs

  5. Power amplifiers for the S-, C-, X- and Ku-bands an EDA perspective

    CERN Document Server

    Božanić, Mladen

    2016-01-01

    This book provides a detailed review of power amplifiers, including classes and topologies rarely covered in books, and supplies sufficient information to allow the reader to design an entire amplifier system, and not just the power amplification stage. A central aim is to furnish readers with ideas on how to simplify the design process for a preferred power amplifier stage by introducing software-based routines in a programming language of their choice. The book is in two parts, the first focusing on power amplifier theory and the second on EDA concepts. Readers will gain enough knowledge of RF and microwave transmission theory, principles of active and passive device design and manufacturing, and power amplifier design concepts to allow them to quickly create their own programs, which will help to accelerate the transceiver design process. All circuit designers facing the challenge of designing an RF or microwave power amplifier for frequencies from 2 to 18 GHz will find this book to be a valuable asset.

  6. High pressure study of viscosity and temperature effects on tetracyanobenzene EDA complexes

    Science.gov (United States)

    Thomas, Michele Moisio; Drickamer, H. G.

    1981-12-01

    High pressure fluorescence studies from 0-10 kbar have been performed on electron donor-acceptor (EDA) complexes of s-tetracyanobenzene (TCNB) with a series of aromatic hydrocarbons. Four solvents were used: 2,2,4,4,6,8,8-heptamethylnonane (HMN), methylcyclohexane (MCH), 2,6,10,14-tetramethylpentadecane (TMPD), and a mixture of MCH and HMN. A viscosity range from 0.006 to 10 000 P was covered at two temperatures: 0 and 25 °C. As pressure (viscosity) increased the fluorescence spectrum shifted from one dominated by emission from the equilibrium (EQ) excited singlet state to one dominated by Franck-Condon (FC) singlet emission. Lifetime measurements for the complexes of o-xylene and p-xylene with TCNB yielded the two radiative rates (kEQ and kFC) as well as the rate of relaxation from FC to the EQ excited state (kRE). kRE was found to correlate well with viscosity and to be independent of temperature at constant viscosity, indicating that the relaxation process is diffusion controlled.

  7. High pressure study of viscosity effects on the luminescence of tetracyanobenzene EDA complexes

    Science.gov (United States)

    Thomas, Michele Moisio; Drickamer, H. G.

    1981-03-01

    High pressure fluorescence studies fron 0-10 kbar have been performed on electron donor-acceptor (EDA) complexes of s-tetracyanobenzene (TCNB) with a series of aromatic hydrocarbons. Four solvents were used, 2,2,4,4,6,8,8 heptamethylnonane (HMN), methylcyclohexane (MCH), 2,6,10,14 tetramethylpentadecane (TMPD), and a mixture of MCH and HMN. A viscosity range from 0.006 to 10 000 poise was covered at constant temperature. As pressure (viscosity) increased the fluorescence spectrum shifted from one dominated by emission from the equilibrium (EQ) excited singlet state to one dominated by Franck-Condon (FC) singlet emission. Lifetime measurements for the complexes of o-xylene and p-xylene with TCNB as well as one mesitylene complex yielded the two radiative rates (kEQ and kFC) as well as the rate of internal conversion from FC to the EQ excited state to (kIC). The results are discussed in terms of the rate of relaxation of the solvent compared with the rate kFC. It was found that kIC correlated very well with the solvent viscosity.

  8. Karistusõiguslik hinnang ohjeldamisele hooldusasutustes / Erkki Hirsnik, Marje Allikmets

    Index Scriptorium Estoniae

    Hirsnik, Erkki, 1982-

    2017-01-01

    Ohjeldamisest tervishoiu- ja hoolekandeasutustes. Ohjeldamise mõistest, seosest kuriteokoosseisudega ja ohjeldusmeetmete õigusvastasuse välistamisest. Ohjeldamise mõistest Saksa õiguses ja kohtupraktikas

  9. PROCESS FOR THE PRODUCTION OF DISSOLVING PULP FROM TREMA ORIENTALIS (NALITA) BY PREHYDROLYSIS KRAFT AND SODA-ETHYLENEDIAMINE (EDA) PROCESS

    OpenAIRE

    M. A. Quaiyyum; A. Noori; Labooni Ahsan; M. Sarwar Jahan

    2008-01-01

    This paper presents a preliminary study for the production of dissolving pulp from Trema orientalis (Nalita). Water prehydrolysis kraft and soda-ethylenediamine (EDA) pulping for the production of dissolving pulp from T. orientalis was investigated. Prehydrolysis at 150 and 170 oC did not produce pulp with high α-cellulose content when using the kraft process. But addition of 0.25 % H2SO4 in prehydrolysis liquor increased the purity of the pulp with the sacrifice of pulp yield and viscosity. ...

  10. Simultaneous Occurence of an Autosomal Dominant Inherited MSX1 Mutation and an X-linked Recessive Inherited EDA Mutation in One Chinese Family with Non-syndromic Oligodontia.

    Science.gov (United States)

    Zhang, Xiao Xia; Wong, Sing Wai; Han, Dong; Feng, Hai Lan

    2015-01-01

    To describe the simultaneous occurence of an autosomal dominant inherited MSX1 mutation and an X-linked recessive inherited EDA mutation in one Chinese family with nonsyndromic oligodontia. Clinical data of characteristics of tooth agenesis were collected. MSX1 and EDA gene mutations were detected in a Chinese family of non-syndromic oligodontia. Mild hypodontia in the parents and severe oligodontia in the son was recorded. A novel missense heterozygous mutation c.517C>A (p.Arg173Ser) was detected in the MSX1 gene in the boy and the father. A homozygous missense mutation c.1001G>A (p.Arg334His) was detected in the EDA gene in the boy and the same mutant occurred heterozygously in the mother. Simultaneous occurence of two different gene mutations with different inheritence patterns, which both caused oligodontia, which occurred in one subject and in one family, was reported.

  11. Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis

    Directory of Open Access Journals (Sweden)

    Binghui Zeng

    2017-10-01

    Full Text Available Abstract: Both X-linked hypohidrotic ectodermal dysplasia (XLHED and non-syndromic tooth agenesis (NSTA result in symptoms of congenital tooth loss. This study investigated genetic causes in two families with XLHED and four families with NSTA. We screened for mutations of WNT10A, EDA, EDAR, EDARADD, PAX9, MSX1, AXIN2, LRP6, and WNT10B through Sanger sequencing. Whole exome sequencing was performed for the proband of NSTA Family 4. Novel mutation c.1051G>T (p.Val351Phe and the known mutation c.467G>A (p.Arg156His of Ectodysplasin A (EDA were identified in families with XLHED. Novel EDA receptor (EDAR mutation c.73C>T (p.Arg25*, known EDA mutation c.491A>C (p.Glu164Ala, and known Wnt family member 10A (WNT10A mutations c.511C>T (p.Arg171Cys and c.742C>T (p.Arg248* were identified in families with NSTA. The novel EDA and EDAR mutations were predicted as being pathogenic through bioinformatics analyses and structural modeling. Two variants of WNT10A, c.374G>A (p.Arg125Lys and c.125A>G (p.Asn42Ser, were found in patients with NSTA. The two WNT10A variants were predicted to affect the splicing of message RNA, but minigene experiments showed normal splicing of mutated minigenes. This study uncovered the genetic foundations with respect to six families with XLHED or NSTA. We identified six mutations, of which two were novel mutations of EDA and EDAR. This is the first report of a nonsense EDAR mutation leading to NSTA.

  12. Prediction of Hexaconazole Concentration in the Top Most Layer of Oil Palm Plantation Soil Using Exploratory Data Analysis (EDA).

    Science.gov (United States)

    Maznah, Zainol; Halimah, Muhamad; Shitan, Mahendran; Kumar Karmokar, Provash; Najwa, Sulaiman

    2017-01-01

    Ganoderma boninense is a fungus that can affect oil palm trees and cause a serious disease called the basal stem root (BSR). This disease causes the death of more than 80% of oil palm trees midway through their economic life and hexaconazole is one of the particular fungicides that can control this fungus. Hexaconazole can be applied by the soil drenching method and it will be of interest to know the concentration of the residue in the soil after treatment with respect to time. Hence, a field study was conducted in order to determine the actual concentration of hexaconazole in soil. In the present paper, a new approach that can be used to predict the concentration of pesticides in the soil is proposed. The statistical analysis revealed that the Exploratory Data Analysis (EDA) techniques would be appropriate in this study. The EDA techniques were used to fit a robust resistant model and predict the concentration of the residue in the topmost layer of the soil.

  13. Prediction of Hexaconazole Concentration in the Top Most Layer of Oil Palm Plantation Soil Using Exploratory Data Analysis (EDA.

    Directory of Open Access Journals (Sweden)

    Zainol Maznah

    Full Text Available Ganoderma boninense is a fungus that can affect oil palm trees and cause a serious disease called the basal stem root (BSR. This disease causes the death of more than 80% of oil palm trees midway through their economic life and hexaconazole is one of the particular fungicides that can control this fungus. Hexaconazole can be applied by the soil drenching method and it will be of interest to know the concentration of the residue in the soil after treatment with respect to time. Hence, a field study was conducted in order to determine the actual concentration of hexaconazole in soil. In the present paper, a new approach that can be used to predict the concentration of pesticides in the soil is proposed. The statistical analysis revealed that the Exploratory Data Analysis (EDA techniques would be appropriate in this study. The EDA techniques were used to fit a robust resistant model and predict the concentration of the residue in the topmost layer of the soil.

  14. Novel 3D modeling methods for virtual fabrication and EDA compatible design of MEMS via parametric libraries

    International Nuclear Information System (INIS)

    Schröpfer, Gerold; Lorenz, Gunar; Rouvillois, Stéphane; Breit, Stephen

    2010-01-01

    This paper provides a brief summary of the state-of-the-art of MEMS-specific modeling techniques and describes the validation of new models for a parametric component library. Two recently developed 3D modeling tools are described in more detail. The first one captures a methodology for designing MEMS devices and simulating them together with integrated electronics within a standard electronic design automation (EDA) environment. The MEMS designer can construct the MEMS model directly in a 3D view. The resulting 3D model differs from a typical feature-based 3D CAD modeling tool in that there is an underlying behavioral model and parametric layout associated with each MEMS component. The model of the complete MEMS device that is shared with the standard EDA environment can be fully parameterized with respect to manufacturing- and design-dependent variables. Another recent innovation is a process modeling tool that allows accurate and highly realistic visualization of the step-by-step creation of 3D micro-fabricated devices. The novelty of the tool lies in its use of voxels (3D pixels) rather than conventional 3D CAD techniques to represent the 3D geometry. Case studies for experimental devices are presented showing how the examination of these virtual prototypes can reveal design errors before mask tape out, support process development before actual fabrication and also enable failure analysis after manufacturing.

  15. Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium

    Czech Academy of Sciences Publication Activity Database

    Peterková, Renata; Kristenová, Pavlína; Lesot, H.; Lisi, S.; Vonesch, J. L.; Gendrault, J. L.; Peterka, Miroslav

    2002-01-01

    Roč. 5, - (2002), s. 215-226 ISSN 1397-5927 R&D Projects: GA AV ČR IAA7039901; GA ČR GA304/02/0448; GA MŠk OC B8.10 Institutional research plan: CEZ:AV0Z5039906 Keywords : development * ectodermal dysplasia * EDA Subject RIV: EA - Cell Biology

  16. A novel point mutation within the EDA gene causes an exon dropping in mature RNA in Holstein Friesian cattle breed affected by X-linked anhidrotic ectodermal dysplasia

    Directory of Open Access Journals (Sweden)

    Pariset Lorraine

    2011-07-01

    Full Text Available Abstract Background X-linked anhidrotic ectodermal dysplasia is a disorder characterized by abnormal development of tissues and organs of ectodermal origin caused by mutations in the EDA gene. The bovine EDA gene encodes the ectodysplasin A, a membrane protein expressed in keratinocytes, hair follicles and sweat glands, which is involved in the interactions between cell and cell and/or cell and matrix. Four mutations causing ectodermal dysplasia in cattle have been described so far. Results We identified a new single nucleotide polymorphism (SNP at the 9th base of exon 8 in the EDA gene in two calves of Holstein Friesian cattle breed affected by ectodermal dysplasia. This SNP is located in the exonic splicing enhancer (ESEs recognized by SRp40 protein. As a consequence, the spliceosome machinery is no longer able to recognize the sequence as exonic and causes exon skipping. The mutation determines the deletion of the entire exon (131 bp in the RNA processing, causing a severe alteration of the protein structure and thus the disease. Conclusion We identified a mutation, never described before, that changes the regulation of alternative splicing in the EDA gene and causes ectodermal dysplasia in cattle. The analysis of the SNP allows the identification of carriers that can transmit the disease to the offspring. This mutation can thus be exploited for a rational and efficient selection of unequivocally healthy cows for breeding.

  17. Detection of a molecular deletion at the DXS732 locus in a patient with X-linked hypohidrotic ectodermal dysplasia (EDA), with the identification of a unique junctional fragment

    Energy Technology Data Exchange (ETDEWEB)

    Zonana, J.; Gault, J.; Jones, M.; Browne, D.; Litt, M. (Oregon Health Sciences Univ., Portland (United States)); Davies, K.J.P.; Clarke, A.; Thomas, N.S.T. (Univ. of Wales, Cardiff (United Kingdom)); Brockdorff, N.; Rastan, S. (Medical Research Council Clinical Research Centre, Harrow (United Kingdom))

    1993-01-01

    X-linked hypohidrotic ectodermal dysplasia (EDA) has been localized to the Xq12-q13.1. A panel of genomic DNA samples from 80 unrelated males with EDA has been screened for deletions at seven genetic loci within the Xq12-13 region. A single individual was identified with a deletion at the DXS732 locus by hybridization with the mouse genomic probe pcos169E/4. This highly conserved DNA probe is from locus DXCrc169, which is tightly linked to the Ta locus, the putative mouse homologue of EDA. The proband had the classical phenotype of EDA, with no other phenotypic abnormalities, and a normal cytogenetic analysis. A human genomic DNA clone, homologous to pcos169E/4, was isolated from a human X-chromosome cosmid library. On hybridization with the cosmid, the proband was found to be only partially deleted at the DXS732 locus, with a unique junctional fragment identified in the proband and in three of his maternal relatives. This is the first determination of carrier status for EDA in females, by direct mutation analysis. Failure to detect deletion of the other loci tested in the proband suggests that the DXS732 locus is the closest known locus to the EDA gene. Since the DXS732 locus contains a highly conserved sequence, it must be considered to be a candidate locus for the EDA gene itself. 18 refs., 3 figs., 1 tab.

  18. Cure and guard. Chronicity in Insane Asylum La Castañeda, Mexico City, 1910-1968

    Directory of Open Access Journals (Sweden)

    Cristina Sacristán

    2017-12-01

    Full Text Available The article questions the binomial that associates the chronicity and incurability of mental illness with the custodialism of the asylum through a case study, Asylum La Castañeda in Mexico, from 1910 to 1968. We contrast the discourses about the cure and chronicity constructed by Mexican psychiatrists and the statistical trends of patients admitted: new admissions, readmissions, discharges, length of stay, and diagnoses in the light of new treatments. We concluded that according to the doctors, the asylum therapeutic function was severely affected by chronicity and overpopulation, but according to statistics, 80% of the patients had only one admission with a 15-month hospitalization and the long-term confinement rates of readmissions did not impact statistically; two-thirds of the patients left the asylum, and since the 1950s in the context of new therapeutics.

  19. Loss-of-coolant and loss-of-flow accident in the ITER-EDA first wall/blanket cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Komen, E.M.J.; Koning, H.

    1995-05-01

    This report presents the analysis of the transient thermal-hydraulic system behaviour inside the first wall/blanket cooling system and the resulting temperature response inside the first wall and blanket of the ITER-EDA (International Thermonuclear Experimental Reactor - Engineering Design Activities) reactor design during a: - Loss-of-coolant accident caused by a reputure of the pump suction pipe; - loss-of-flow accident caused by a trip of the recirculation pump. (orig.).

  20. Loss-of-coolant and loss-of-flow accident in the ITER-EDA first wall/blanket cooling system

    International Nuclear Information System (INIS)

    Komen, E.M.J.; Koning, H.

    1995-05-01

    This report presents the analysis of the transient thermal-hydraulic system behaviour inside the first wall/blanket cooling system and the resulting temperature response inside the first wall and blanket of the ITER-EDA (International Thermonuclear Experimental Reactor - Engineering Design Activities) reactor design during a: - Loss-of-coolant accident caused by a reputure of the pump suction pipe; - loss-of-flow accident caused by a trip of the recirculation pump. (orig.)

  1. The group A streptococcal collagen-like protein 1, Scl1, mediates biofilm formation by targeting the EDA-containing variant of cellular fibronectin expressed in wounded tissue

    Science.gov (United States)

    Oliver-Kozup, Heaven; Martin, Karen H.; Schwegler-Berry, Diane; Green, Brett J.; Betts, Courtney; Shinde, Arti V.; Van De Water, Livingston; Lukomski, Slawomir

    2012-01-01

    Summary Wounds are known to serve as portals of entry for group A Streptococcus (GAS). Subsequent tissue colonization is mediated by interactions between GAS surface proteins and host extracellular matrix components. We recently reported that the streptococcal collagen-like protein-1, Scl1, selectively binds the cellular form of fibronectin (cFn) and also contributes to GAS biofilm formation on abiotic surfaces. One structural feature of cFn, which is predominantly expressed in response to tissue injury, is the presence of a spliced variant containing extra domain A (EDA/EIIIA). We now report that GAS biofilm formation is mediated by the Scl1 interaction with EDA-containing cFn. Recombinant Scl1 proteins that bound cFn also bound recombinant EDA within the C-C′ loop region recognized by the α9β1 integrin. The extracellular 2-D matrix derived from human dermal fibroblasts supports GAS adherence and biofilm formation. Altogether, this work identifies and characterizes a novel molecular mechanism by which GAS utilizes Scl1 to specifically target an extracellular matrix component that is predominantly expressed at the site of injury in order to secure host tissue colonization. PMID:23217101

  2. Exploratory and spatial data analysis (EDA-SDA) for determining regional background levels and anomalies of potentially toxic elements in soils from Catorce-Matehuala, Mexico

    Science.gov (United States)

    Chiprés, J.A.; Castro-Larragoitia, J.; Monroy, M.G.

    2009-01-01

    The threshold between geochemical background and anomalies can be influenced by the methodology selected for its estimation. Environmental evaluations, particularly those conducted in mineralized areas, must consider this when trying to determinate the natural geochemical status of a study area, quantifying human impacts, or establishing soil restoration values for contaminated sites. Some methods in environmental geochemistry incorporate the premise that anomalies (natural or anthropogenic) and background data are characterized by their own probabilistic distributions. One of these methods uses exploratory data analysis (EDA) on regional geochemical data sets coupled with a geographic information system (GIS) to spatially understand the processes that influence the geochemical landscape in a technique that can be called a spatial data analysis (SDA). This EDA-SDA methodology was used to establish the regional background range from the area of Catorce-Matehuala in north-central Mexico. Probability plots of the data, particularly for those areas affected by human activities, show that the regional geochemical background population is composed of smaller subpopulations associated with factors such as soil type and parent material. This paper demonstrates that the EDA-SDA method offers more certainty in defining thresholds between geochemical background and anomaly than a numeric technique, making it a useful tool for regional geochemical landscape analysis and environmental geochemistry studies.

  3. Propiedades psicométricas de la Escala para la Detección de la Ansiedad Social (EDAS en una muestra de adolescentes chilenos

    Directory of Open Access Journals (Sweden)

    Pablo Vera-Villarroe

    2007-01-01

    Full Text Available En el presente estudio instrumental examinamos la fiabilidad y validez estructural de la versión chilena de la Escala para la Detección de la Ansiedad Social (EDAS, utilizando una muestra de 1040 adolescentes (rango de edad entre 13 y 18 años. El análisis de validez indicó que en cada una de las subescalas (Evitación, Grado de ansiedad e Interferencia tan sólo se apreció una sola dimensión que explicó más de un 40% de la varianza. Los coeficientes de fiabilidad obtenidos (alfa de Guttman- Cronbach y de Spearman-Brown fueron altos en cada una de las subescalas. No se encontraron diferencias significativas debidas al sexo, a la edad y a la interacción entre el sexo y la edad, excepto el efecto debido a la edad en las subescalas Grado de Ansiedad e Interferencia. Los resultados, en general, aportan evidencia empírica a favor de la fiabilidad y la validez de la versión chilena de la EDAS. Se propone evaluar la relación entre EDAS y otros instrumentos similares en la población chilena.

  4. Pharmacological activation of the EDA/EDAR signaling pathway restores salivary gland function following radiation-induced damage.

    Directory of Open Access Journals (Sweden)

    Grace Hill

    Full Text Available Radiotherapy of head and neck cancers often results in collateral damage to adjacent salivary glands associated with clinically significant hyposalivation and xerostomia. Due to the reduced capacity of salivary glands to regenerate, hyposalivation is treated by substitution with artificial saliva, rather than through functional restoration of the glands. During embryogenesis, the ectodysplasin/ectodysplasin receptor (EDA/EDAR signaling pathway is a critical element in the development and growth of salivary glands. We have assessed the effects of pharmacological activation of this pathway in a mouse model of radiation-induced salivary gland dysfunction. We report that post-irradiation administration of an EDAR-agonist monoclonal antibody (mAbEDAR1 normalizes function of radiation damaged adult salivary glands as determined by stimulated salivary flow rates. In addition, salivary gland structure and homeostasis is restored to pre-irradiation levels. These results suggest that transient activation of pathways involved in salivary gland development could facilitate regeneration and restoration of function following damage.

  5. Campylobacter jejuni en niños con enfermedad diarréica aguda (E.D.A

    Directory of Open Access Journals (Sweden)

    Fabio Carmona V.

    1987-06-01

    Full Text Available En el período comprendido entre el 15 de septiembre de 1985 y septiembre 30 de 1986 fueron estudiados en Cali, Valle, Colombia, 231 niños que consultaron por enfermedad diarreica aguda (EDA; 137 provenían del Hospital Infantil, Club Noel y el resto del Centro de Salud de Siloé y del Hospital Universitario del Valle (HUV. El estudio de heces mostró Campylobacter jejuni (CJ en 31 (13.4%. Los 137 pacientes del Club Noel fueron estudiados también buscando Salmonella, Shigella, E. coli enterotoxigénico, encontrándose que el CJ fue el único gérmen en 13 pacientes (9.5% de los 19 aislamientos logrados en esta Institución. Todos los pacientes cursaron con los signos y síntomas típicos de la enfermedad; fiebre, diarrea, vómito, deposición mucosa o sanguinolenta. En cuanto al sexo hubo una relación niño:niña de 2:1 y el grupo de edad más comprometido fue hasta los 2 años, con promedio máximo hacia los 12 meses.

  6. Characterization of a human X-linked gene from the DXS732E locus in the candidate region for the anhidrotic ectodermal dysplasia (EDA) gene (Xq13.1)

    Energy Technology Data Exchange (ETDEWEB)

    Gault, J.; Zonana, J. [Oregon Health Sciences Univ., Portland, OR (United States); Zeltinger, J. [Univ. of Washington, Seattle, WA (United States)] [and others

    1994-09-01

    A conserved mouse genomic clone was used to identify a homologous human genomic clone (the DXS732E locus), which was subsequently employed to isolate cDNAs from a human fetal brain library. Nine unique overlapping cDNAs were isolated, and sequences analysis of 3.9 kb identified a putative 1 kb ORF. GRAIL analysis of the sequence supported the hypothesis that the putative ORF was coding sequence, and Prosite analysis of the putative ORF identified potential glycosylation and phosphorylation sites. The 5{prime} end of the gene maps within a CpG island, and comparison of cDNA sequences indicate the gene is alternatively spliced at its 3{prime} end. Northern analysis and RT-PCR indicate that two different sized messages appear to be expressed with the gene expressed in human fetal kidney, intestine, brain, and muscle. The gene is expressed in 77 day human skin, a time when hair follicle formation occurs. Anhidrotic ectodermal dysplasia (EDA) results in the abnormal morphogenesis of hair, teeth and eccrine sweat glands. A positional cloning strategy towards cloning the EDA gene had been used, and deletion and X-autosome translocation patients have been useful in further delimiting the EDA region. The present gene at the DXS732E locus is partially deleted in one EDA patient who does not have other apparent abnormalities. No rearrangements of the gene have been detected in two female X-autosome translocation EDA patients, nor in four additional male patients with submicroscopic molecular deletions.

  7. Los pacientes del Manicomio La Castañeda y sus diagnósticos. Una propuesta desde la historia cuantitativa (México, 1910-1968

    Directory of Open Access Journals (Sweden)

    Ríos Molina, Andrés

    2016-06-01

    Full Text Available During its 58 years in operation (1910-1968, the Manicomio General La Castañeda housed 61,480 people. In this paper, we present an overview of the general characteristic of the patients based on a 20% sample of the overall population. We divided the text in three sections: in the first part we argue that the history of the institution comprises three distinctive periods characterized by demographic changes that coincide with administrative reforms. In the second, we present the general characteristics of La Castañeda's psychiatric population. Finally, we describe the most salient demographic changes, which stemmed either from socio-political events, technological innovations or clinical transformations. Some of the most salient results of the analysis of the sample show that the inmate population had short periods of hospitalization in the asylum (an average of 18 month, as well as a lower mortality rate (24.2% in comparison to contemporary mental institutions. Families played a fundamental role in the care of their mad relatives, which accounts for the relatively short periods of hospitalization as well as the low death rates. Consequently, for this particular institution, chronic patients weren't such a serious problem as believed.El Manicomio General La Castañeda, fundado en la Ciudad de México, albergó a 61.480 pacientes entre 1910 y 1968. El objetivo de este artículo es presentar un panorama general de la población que ingresó a esta institución y los diagnósticos que recibieron los internos, análisis realizado a partir de una base de datos construida con una muestra de 20% de la población total. El artículo se divide en tres partes: en la primera, proponemos tres etapas para comprender la historia de La Castañeda cuya periodización es definida por cambios demográficos que coinciden con reformas administrativas; en la segunda, exponemos las características generales de la población psiquiátrica de La Castañeda; y

  8. A novel missense mutation (402C-->T) in exon 1 in the EDA gene in a family with X-linked hypohidrotic ectodermal dysplasia

    DEFF Research Database (Denmark)

    Hertz, Jens Michael; Nørgaard Hansen, K; Juncker, I

    1998-01-01

    Hypohidrotic ectodermal dysplasia (EDA), or Christ-Siemens-Touraine syndrome, is clinically characterized by hypohidrosis, hypoodontia and hypotrichosis. The X-linked form of the disease has been mapped to Xq12-q13.1, and a gene from this region has recently been cloned. This gene encodes a predi...... in the protein. This mutation cosegregates with the disease in the family and is the first mutation described which affects the predicted transmembrane, hydrophobic domain of the protein.......Hypohidrotic ectodermal dysplasia (EDA), or Christ-Siemens-Touraine syndrome, is clinically characterized by hypohidrosis, hypoodontia and hypotrichosis. The X-linked form of the disease has been mapped to Xq12-q13.1, and a gene from this region has recently been cloned. This gene encodes...... a predicted transmembrane protein of 135 amino acids, which was found to be expressed in keratinocytes, hair follicles, and sweat glands. A variety of rearrangements in this gene have been found in patients with hypohidrotic ectodermal dysplasia. We have screened the probands from nine unrelated Danish...

  9. EDA-EMERGE : An FP7 initial training network to equip the next generation of young scientists with the skills to address the complexity of environmental contamination with emerging pollutants

    NARCIS (Netherlands)

    Brack, Werner; Govender, Selvan; Schulze, Tobias; Krauss, Martin; Hu, Meng; Muz, Melis; Hollender, Juliane; Schirmer, Kristin; Schollee, Jennifer; Hidasi, Anita; Slobodnik, Jaroslav; Rabova, Zuzana; Ait-Aissa, Selim; Sonavane, Manoj; Carere, Mario; Lamoree, Marja; Leonards, Pim; Tufi, Sara; Ouyang, Xiyu; Schriks, Merijn; Thomas, Kevin; De Almeida, Ana Catarina; Froment, Jean; Hammers-Wirtz, Monika; Ahel, Marijan; Koprivica, Sanja; Hollert, Henner; Seiler, Thomas Benjamin; Di Paolo, Carolina; Tindall, Andrew; Spirhanzlova, Petra

    2013-01-01

    The initial training network consortium novel tools in effect-directed analysis to support the identification and monitoring of emerging toxicants on a European scale (EDA-EMERGE) was formed in response to the seventh EU framework program call to train a new generation of young scientists (13 PhD

  10. The Ru-NO bonding in nitrosyl-[poly(1-pyrazolyl)borate]ruthenium complexes: a theoretical insight based on EDA

    Energy Technology Data Exchange (ETDEWEB)

    Caramori, Giovanni F.; Kunitz, Andre G.; Coimbra, Daniel F.; Garcia, Leone C.; Fonseca, David E.P., E-mail: giovanni.caramori@ufsc.br [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Centro de Ciencias Fisicas e Matematicas. Dept. de Quimica

    2013-09-15

    The lability of NO{sup +} group in [TpRuCl{sub 2}(NO)]{sup q} (Tp = BL(pyrazol-1-yl){sub 3}) complexes was evaluated at the light of energy decomposition analysis (Su-Li EDA). The electronic effects of different pseudoaxial substituents (L = H, pyrazolyl anion, pyrazole, isoxazole and isothiazole) on the nature of Ru-NO bonding were evaluated considering complexes in ground (GS) and in metastable (MS1 and MS2) states. (Ru-NO){sup 6} bond nature in [TpRuCl{sub 2}(NO)]{sup q} (Tp = BL(pyrazol-1-yl){sub 3}) complexes is in essence covalent, but with a still significant electrostatic character. The nature of pseudoaxial substituents has a direct effect on the magnitude of (Ru-NO){sup 6} bonds. (author)

  11. Por el bien de la economía nacional: trabajo terapéutico y asistencia pública en el Manicomio de La Castañeda de la ciudad de México, 1929-1932 For the good of the nation's economy: therapeutic work and public assistance at La Castañeda asylum in Mexico City, 1929-32

    Directory of Open Access Journals (Sweden)

    Cristina Sacristán

    2005-12-01

    Full Text Available El Manicomio de La Castañeda de la Ciudad de México, fundado en 1910, enfrentó hacia 1930 el problema de su masificación debido al elevado número de pacientes crónicos que hacían ver a la institución como un depósito de enfermos más que como un espacio terapéutico. Esta circunstancia condujo a la psiquiatría a su primera crisis de legitimidad como ciencia. Con el objetivo de combatir la leyenda negra en torno al manicomio, los médicos de La Castañeda promovieron la difusión en la prensa de un tratamiento de origen decimonónico que proyectaba la imagen pública de que los enfermos mentales podían tener la misma capacidad productiva que el resto de los hombres: la terapéutica por medio del trabajo. Esta propuesta contó con el apoyo del Estado emanado de la revolución mexicana porque el objetivo que guiaba la asistencia pública a los grupos más desprotegidos consistía en lograr su integración a la vida productiva del país a través del mercado, lo que se obtenía en el caso de los enfermos mentales a través de la terapia ocupacional.Founded in 1910, by 1930 Mexico City's La Castañeda insane asylum was grappling with the problem of a massive number of chronic patients, a situation that earned it an image as a warehouse for the sick more than a place of treatment. Psychiatrists endeavored to restore the asylum's legitimacy by publicizing a nineteenth-century treatment which projected the public image that the mentally ill could be as productive as anyone else: work therapy. The government born of the Mexican revolution supported this proposal because the guiding objective behind public assistance for underprivileged groups was to make them part of the country's productive life via the market.

  12. Loovutatava isiku õigused loovutamismenetluses. Kohtupraktika analüüs / Marje Allikmets

    Index Scriptorium Estoniae

    Allikmets, Marje, 1989-

    2013-01-01

    Euroopa vahistamismääruse alusel toimuvast loovutamismenetlusest. Loovutatava isiku õiguste kaitse probleemidest. Artikkel põhineb autori 2013. a. Tartu Ülikooli õigusteaduskonnas kaitstud magistritööl "Loovutatava isiku õigused loovutamismenetluses - kohtupraktika analüüs"

  13. Defining and modeling the soil geochemical background of heavy metals from the Hengshi River watershed (southern China): Integrating EDA, stochastic simulation and magnetic parameters

    International Nuclear Information System (INIS)

    Zhou Xu; Xia Beicheng

    2010-01-01

    It is crucial to separate the soil geochemical background concentrations from anthropogenic anomalies and to provide a realistic environmental geochemical map honoring the fluctuations in original data. This study was carried out in the Hengshi River watershed, north of Guangdong, China and the method proposed combined exploratory data analysis (EDA), sequential indicator co-simulation (SIcS) and the ratio of isothermal remnant magnetization (S 100 = -IRM -100mT /SIRM). The results showed that this is robust procedure for defining and mapping soil geochemical background concentrations in mineralized regions. The rock magnetic parameter helps to improve the mapping process by distinguishing anthropogenic influences. In this study, the geochemical backgrounds for four potentially toxic heavy metals (copper 200 mg/kg; zinc 230 mg/kg; lead 190 mg/kg and cadmium 1.85 mg/kg) Cu, Zn and Cd exceeded the soil Grade II limits (for pH < 6.5) from the Chinese Environmental Quality Standard for Soils (GB 15618-1995) (EQSS) which are 100, 200, 250 and 0.3 mg/kg for Cu, Zn, Pb and Cd, respectively. In particular, the geochemical background level for Cd exceeds standard six times. Results suggest that local public health is at high-risk along the riparian region of the Hengshi River, although the watershed ecosystem has not been severely disturbed.

  14. Las plantas americanas en la obra de Charles de l'Écluse: primeras citas en las cartas de Juan de Castañeda

    Directory of Open Access Journals (Sweden)

    Ramón-Laca Menéndez de Luarca, Luis

    1999-06-01

    Full Text Available The Flemish botanist Charles de l'Écluse's works contain abundant references to American plants, for example the avocado (Persea americana Mill., the sweet potato [Ipomoea batatas (L. Lam.], the potato (Solanum tuberosum L. and the tobáceo (Nicotiana tabacum L.. Although some of these plants were observed by L'Écluse himself during his expedition to the Iberian Península between 1564 and 1565, the majority of the American plants quoted in his works are related with shipments received from several agents around Europe. In the case of Spain, L'Écluse obtained seeds from Seville thanks to the help of Simón de Tovar and Juan de Castañeda. The latter offers in his letters important innovations: Annona cherimola Mill., Indigofera añil LJI. tinctoria L., Annona muricata L., Mammea americana L.. Annona reticulata L., Dioscorea sp., Aloysia citrodora Palau or Manihot spj M. esculenta Crantz. In most of the cases the mention of these plants represente the first record of cultivation in the Old World. A percentage of this material was used by L'Écluse in his Exoticorum libri decem, published in Antwerp in l605.Las obras del botánico flamenco Charles de l'Écluse contienen infinidad de referencias a plantas americanas, destacando entre ellas el aguacate (Persea americana Mill., las batatas [Ipomoea batatas (L. Lam.], las patatas (Solanum tuberosum L. o el tabaco (Nicotiana tabacum L. . Algunas de ellas fueron observadas por L'Écluse durante la expedición llevada a cabo por la Península Ibérica entre 1564 y 1565. La mayor parte de plantas americanas citadas en sus obras están relacionadas sin embargo con envíos realizados por diversos corresponsales repartidos por Europa. En el caso de España, L'Écluse recibió semillas desde Sevilla gracias a Simón de Tovar y Juan de Castañeda. Este último ofrece en sus cartas importantes novedades, como el "anón" (Annona cherimola Mill., el "añil" (Indigofera añil L./I. tinctoria L., la "guan

  15. Status of the ITER EDA

    International Nuclear Information System (INIS)

    Aymar, R.

    1999-01-01

    This article summarises progress made in the ITER Design Activities between October 1998 and February 1999. The three main focusses of the activity were on design work, on R and D work and on the physics basis. The consequences of diminishing financial funds and personnel are discussed and the state of the individual R and D projects is given briefly

  16. Ken Saan / Ken Saan ; interv. Eda Post

    Index Scriptorium Estoniae

    Saan, Ken

    2006-01-01

    Kanal 2 uue tõsielusarja produtsent, mitmete ESTO TV saadete saatejuht ja filmide "Welcome to Estonia" ja "Vali kord" peategelasi oma tegemistest ja arusaamadest. Lisatud Andres Maimiku arvamus "Oskab ja püüab kõike ise teha"

  17. ITER EDA newsletter. V. 8, no. 6

    International Nuclear Information System (INIS)

    1999-06-01

    A ceremony was held on 1 June 1999 at the Naka Fusion Research Establishment of JAERI to celebrate the successful development and fabrication of the ITER Central Solenoid Model Coil Inner Module and Outer Module and the CS Insert Coil. At this occasion, Dr. Martha Krebs from the US-DOE regretted the withdrawal of the United States from the ITER project, the US are now looking for Japan, the European Union and the Russian Federation to continue making progress. In response to this speech, Mr. Tsutomu Imamura said, that that was to be regretted and stated that Japan actively promoted the ITER project. Then, Dr. Michel Huguet, representing the JCT, presented a message from Dr. R. Aymar, the director of the ITER program. In this message he indicated that each and every one who had been involved in that project could take great pride. The ceremony was concluded by warm and thoughtful words from Dr. Masami Fujiwara and a toast by Dr. Masaji Yoshikawa. At the end, all participants praised each other for their efforts and the three coils, the CS Model Coil Inner Module, the Outer Module and the the CS Insert Coil, seemed to be smiling at them

  18. ITER EDA newsletter. V. 8, no. 3

    International Nuclear Information System (INIS)

    1999-03-01

    This newsletter contains reports on: 'The ITER management advisory committee (MAC) meeting in Cadarache' and on 'ITER technical advisory committee meeting at Garching'. It contains photos of the participants of both meetings

  19. ITER EDA newsletter. V. 7, No. 4

    International Nuclear Information System (INIS)

    1998-04-01

    This issue contains a report by A.E Costly and K.M. Young on the 8. ITER Diagnostics Expert Group which was held in San Diego, 11-13 February and a summary of a survey study prepared by C.D. Hillebrand on Fusion Research and Technology records in INIS database

  20. ITER EDA Newsletter. V.2, no.6

    International Nuclear Information System (INIS)

    1993-06-01

    This issue of the newsletter on the Engineering Design Activities for the ITER Project includes (i) a status report on these activities describing the development of the design and design parameters, the research and development program, the joint central team, and the joint work sites; (ii) a description of the In-Vessel Ancillaries Division (consisting of the RF Heating and Current Drive Group and the In-Vessel Diagnostics Group) including its organizational chart and priorities of activities; (iii) a report on the Technical Meeting on Design Standards and Remote Handling held at the San Diego Co-Centre from May 24-28, 1993; (iv) and a report on a Technical Committee Meeting on Plasma Equilibrium and Control held at the Naka Co-Centre on April 26-29, 1993

  1. Hiinlane, kes leidis Tallinnast linnahalli / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2007-01-01

    Tallinna Tehnikakõrgkooli konverentsi "Linn kui elukeskkond" peaesineja Hiina arhitekt Chi Ti-Nan (s. 1957) korraldas üliõpilastega töötoa, et leida uusi ideid Tallinna Linnahalli elavdamiseks ja rakenduseks

  2. ITER EDA Newsletter. V. 6, no. 9

    International Nuclear Information System (INIS)

    1997-09-01

    This issue of the Newsletter reports on new ITER Home Page and contains a report on the combined workshop of the ITER confinement and transport expert group and of the confinement modeling and database expert group, by D. Boucher, V. Mukhavatov (both ITER JCT), J.G. Cordey, JET Joint Undertaking , M. Wakatani, Kyoto University held at the Max-Planck-Institut for Plasmaphysik, Garching, Germany on September 25 - 30 1997

  3. ITER EDA newsletter. V. 5, no. 5

    International Nuclear Information System (INIS)

    1996-05-01

    This issues of the ITER Engineering Design Activities Newsletter contains a report on the Tenth Meeting of the ITER Management Advisory Committee held at JAERI Headquarters, Tokyo, June 5-6, 1996; on the Fourth ITER Divertor Physics and Divertor Modelling and Database Expert Group Workshop, held at the San Diego ITER Joint Worksite, March 11-15, 1996, and on the Agenda for the 16th IAEA Fusion Energy Conference (7-11 October 1996)

  4. ITER EDA newsletter. V. 8, no. 5

    International Nuclear Information System (INIS)

    1999-05-01

    This newsletter reports on the sequence of events related to the installation of the two central solenoid model coil modules and of the central solenoid insert coil in the testing vacuum tank at JAERY Naka Fusion Research Establishment and on the combined meeting of the core confinement and internal transport barrier expert group, confinement database and modeling expert group and edge pedestal expert group in Garching, Germany

  5. ITER EDA newsletter. V. 10, no. 2

    International Nuclear Information System (INIS)

    2001-02-01

    In 2000, the Fusion Power Associates Awards were given, among others, to persons closely associated with the developments of ITER. These Awards are given annually for Distinguished Career, for Leadership, and for Excellence in Fusion Engineering. Distinguished Career Award to Ken Tomabechi, a leading fusion researcher and director of the Japan Atomic Energy Research Institute. Leadership Award to: Robert Aymar, a leading European fusion researcher and has been ITER Director since 1994. Excellence in Fusion Engineering to: Gianfrano Federici, a staff member of the ITER Joint Central Team, working at the ITER Joint Work Site at Garching, Germany

  6. ITER EDA newsletter. V. 7, no. 6

    International Nuclear Information System (INIS)

    1998-06-01

    This newsletter contains the articles: 'ITER representation at the 11th Pacific Basin Nuclear Conference', 'Summary of discussion points and further deliberations in the special committee on the ITER project in the Atomic Energy Commission', and 'ITER radio frequency systems'

  7. ITER EDA newsletter. V. 7, no. 10

    International Nuclear Information System (INIS)

    1998-10-01

    This newsletter contains three articles, namely a report on an ITER meeting (October 20-21,1998) in Yokohama, Japan, a short note on the 17th IAEA Fusion Energy Conference (October 19-24, 1998) in Yokohama and a monograph by ITER Director R. Aymar on 'the Legacy of Artsimovitch and the lessons of ITER'

  8. ITER EDA Newsletter. V. 6, no. 8

    International Nuclear Information System (INIS)

    1997-08-01

    This issue of the Newsletter contains a report on blanket remote handling development by K. Shibanuma, R. Haange ( both ITER Joint Central Team) and E. Tada (Japan Home Team) and a report on Fusion research support by the IAEA by T.J. Dolan and U. Schneider Physics Section, IAEA

  9. ITER EDA newsletter. V. 7, special issue

    International Nuclear Information System (INIS)

    1998-07-01

    In conjunction with the ITER Council Meeting, a ceremony was held at the IAEA Headquarters in Vienna on 22 July 1998 to celebrate the achievements of the ITER Engineering Design Activities during the period 1992-1998

  10. ITER EDA newsletter. V. 5, no. 6

    International Nuclear Information System (INIS)

    1996-06-01

    This issue of the ITER Engineering Design Activities Newsletter contains a report on the Tenth Meeting of the ITER Technical Advisory Committee; on the papers relevant to the ITER project that were presented during the 12th International Conference on Plasma-Surface Interactions in Controlled Fusion Devices held at St. Raphael, France, on 20-24 May 1996; and a note on the interrelationship between ITER and the PSI Conference, initiated more than twenty years ago by surface and solid-state physicists

  11. ITER EDA newsletter. V. 9, no. 6

    International Nuclear Information System (INIS)

    2000-06-01

    This newsletter contains the reports of the twelfth meeting of the ITER physics expert group on diagnostics and the 14. international conference on plasma-surface interactions in controlled fusion devices. Individual abstracts have been prepared

  12. Kas Peterburi on ohus? / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2007-01-01

    Maailma Monumentide Fond (World Monuments Fund) avaldas järjekordse nimekirja maailma sajast kõige suuremas ohus olevast mälestusmärgist. Nimekirjas on Peterburi siluett, Mendelejevi Instituudi torn Peterburis, Ljunbergi hall Rootsis jt. Täielik nimekiri aadressil www.WorldMonumentsWatch.org

  13. ITER EDA newsletter. V. 7, no. 5

    International Nuclear Information System (INIS)

    1998-05-01

    This newsletter contains the articles 'The materials selection in ITER and the first materials workshop', 'US fusion community discussion on fusion strategies', 'ITER central solenoid model coil heat treatment complete and assembly started' and 'Programme of the 17th IAEA fusion energy conference'. There is also a note in memoriam of Hiroschi Shibata, who died on the 5th of June 1998

  14. Vilve Undi 50 kleiti / Eda Allikmaa

    Index Scriptorium Estoniae

    Allikmaa, Eda, 1961-

    2006-01-01

    Eesti Kunstiakadeemia moeosakonna juhataja professor Vilve Unt meenutab Eesti viimase 50 aasta moelugu näitusega "50 kleiti" Eesti Tarbekunsti- ja disainimuuseumis, tähistades nõnda oma esimest juubelit. Lisaks tema kommentaarid, iseloomustamaks erinevate aastakümnete moodi (1961,1971, 1981)

  15. ITER EDA newsletter. V. 7, no. 1

    International Nuclear Information System (INIS)

    1998-01-01

    This issue of the ITER Newsletter contains a summary report on the Thirteenth meeting of the ITER Management Advisory Committee (MAC), a report on ITER at the International Conference on Fusion Reactor Materials and a report of a Russian scientist working at ITER Garching JWS

  16. ITER EDA newsletter. V. 8, no. 7

    International Nuclear Information System (INIS)

    1999-07-01

    This newsletter contains an article concerning the ITER divertor cassette project meeting in Bologna, Italy (May 26-28, 1999), and an emotional outburst, concerning the closure of the ITER site in San Diego, USA

  17. ITER EDA newsletter. V. 5, no. 2

    International Nuclear Information System (INIS)

    1996-02-01

    This issue of the Newsletter reports on the First Technical Meeting on ITER Neutral Beam Injection held at Naka, Japan, 13-16 February 1996, and on the First Workshop on Energetic Particles and Heating and Current Drive held at the Kurchatov Institute, Moscow, Russia, on October 2 - 6, 1995

  18. ITER EDA newsletter. V. 6, no. 12

    International Nuclear Information System (INIS)

    1997-12-01

    This issue of the ITER Newsletter contains summary reports (i) on the Sixth ITER Technical Meeting on Safety and Environment and (ii) on JAERI's Annual Public Seminar on Fusion Research and Development

  19. ITER EDA newsletter. V. 5, no. 3

    International Nuclear Information System (INIS)

    1996-03-01

    This issue of the Newsletter provides a summary of the NSSR-1 Working Meeting held in San Diego, February 26 - March 1, 1996 and on the First Industry Liaison Meeting held in San Diego at the end of July, 1996. It also features a contribution entitled ''Remote Control of ITER Experiments''

  20. Soomlased toovad natsid Kuu pealt / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    Soome ingliskeelse täispika supermenuka internetifilmi "Star Wreck : In the Pirkinning" (2005) loojad Timo Vuorensola ja Samuli Torssonen töötavad ulmelise musta komöödia "Iron Sky" kallal, stsenaariumi kirjutab Johanna Sinisalo. Lisatud "Mis on "Star Wreck"?"

  1. Mida lapsevanem koolilt ootab? / Eda Heinla

    Index Scriptorium Estoniae

    Heinla, Eda

    1999-01-01

    Artikkel põhineb uurimusel, mille eesmärgiks oli saada ülavaade lapsevanemate ootustest koolikeskkonnale kui laste oskuste kujundajale ja loovate võimete arendajale, aluseks elanikkonna küsitlus "Eesti 1998"

  2. K. Linda Kivi autoriõhtu Tartu College´is / Eda Sepp ; fotod: Eda Sepp

    Index Scriptorium Estoniae

    Sepp, Eda

    2006-01-01

    19. jaanuaril 2006, Linda Kivi kolmanda raamatu "The Inner Green: Exploring Home in the Columbia Mountains" raamatuesitlusest. Korraldajateks Toronto Ülikooli Eesti Õppetool, Tartu Instituut, Tartu College´i laenuraamatukogu

  3. Varjupaigalapsed - sotsiaalses ohus elavad ühiskonnaliikmed / Eda Heinla

    Index Scriptorium Estoniae

    Heinla, Eda, 1953-

    2005-01-01

    Autori hinnangul on korduvalt varjupaigas viibivate laste toimetuleku kindlustamisega viivitamise tulemuseks sotsiaalses riskis elavate laste liikumine tõrjutute rühma juba nooruki eas. Diagrammid. Tabel. Graafik

  4. The Impact of the Eda Pathway on Tooth Root Development.

    Czech Academy of Sciences Publication Activity Database

    Fons Romero, J.M.; Star, H.; Lav, R.; Watkins, S.; Harrison, M.; Hovořáková, Mária; Headon, D.; Tucker, Abigail

    2017-01-01

    Roč. 96, č. 11 (2017), s. 1290-1297 ISSN 0022-0345 R&D Projects: GA ČR(CZ) GB14-37368G Institutional support: RVO:68378041 Keywords : tooth * ectodermal dysplasia * epithelium Subject RIV: EA - Cell Biology OBOR OECD: Developmental biology Impact factor: 4.755, year: 2016

  5. Hooajal asutatud toitlustaja kaob turult / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2003-01-01

    Eesti catering-teenuste turg ning ettevõtted. Tabelid: Toitlustusteenus võrdne kalli restorani hindadega - ürituste hinnad; Tuntumad toitlustusfirmad. Kommenteerivad Riho Rasmann ja Hede Kerstin Luik. Frens pakub kõige maitsvamaid suupisteid - catering-firmade pimetesti tulemused

  6. TOP 30 - valdavalt eraettevõtted / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti : Desjatiletnije firmõ 4. veebr. lk. 11. Eesti Tööstuse Keskliidu poolt 1994. aastal koostatud 30 edukama ettevõtte edetabelist. 1994. aasta äritegevust meenutavad Balti Laevaremonditehase peadirektor Fjodor Berman ja Saku Õlletehase direktor Cardo Remmel. Lisa: 30 Eesti edukat

  7. Turundajad ei oska kasutada kogutud kliendiinfot / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Eesti kaupmehed koguvad kliendiinfot, kuid klientide kasumlikkust ei arvutata. Lisa: Kliendid pole motiveeritud oma ostu registreerima; Tesco põhilised erinevused võrreldes Eesti lojaalsusprogrammidega; Partnerkaart; Säästukaart; Stockmanni püsikliendikaart

  8. Pillide kuningannal oma fond / Eda Liiväär

    Index Scriptorium Estoniae

    Liiväär, Eda

    2006-01-01

    Eesti Rahvuskultuuri Fondi allfondi - Eesti Klaverifondi avamise tähistamisest disainklaverite näituse ja Rein Rannapi kontserdiga 8. juunil Viru keskuses. OÜ Reval Piano poolt loodud sihtasutusest Eesti Rahvuslik Klaverimuuseum

  9. The tubular separate first wall for ITER EDA

    International Nuclear Information System (INIS)

    Pizzuto, A.; Riccardi, B.; Salpietro, E.

    1994-01-01

    The first wall is one of the most loaded plasma-facing components, the heat flux is such that the thermal stresses are the most important design concern. In addition, the First Wall shall resist the eddy current induced plasma disruption, the high pressure of the coolant without leaking ( -6 Torr-lit/sec.) and it should maintain its properties under fast neutron flux (dose up to 3 MW/m 2 ). The tubular solution is the most suitable one to cope with the thermal stresses, the use of double wall reduces the risk of leaks inside the vacuum vessel by avoiding the growth of a crack through both walls: the soft brazing in between walls stops the growth of a crack from one tube to the other. The eddy currents induced in the tubes are low and the Halo current flowing poloidally in the tubes exert a radial pressure which is supported by the blanket box via ad hoc supporting points provided in between first wall and blanket. Conclusions from the thermo-hydraulic analysis and the electromagnetic analysis will be presented including dynamic analysis. Also results of preliminary technological tests on coatings will be discussed

  10. Music as EDAE: Implications for Music Therapy Nigeria | Aluede ...

    African Journals Online (AJOL)

    The use of music under social, political, apolitical, moral, amoral and religious circumstances in Africa is evidenced not just by the quality and quantity of the work done in this area of scholarship but, by the corpus of traditional songs whose texts, when critically examined lead us to important conclusions in forming opinions ...

  11. But what about girls? : introduction into girls' studies / Eda Kalmre

    Index Scriptorium Estoniae

    Kalmre, Eda, 1958-

    2012-01-01

    5203 Tutvustus: Entäs tytöt : johdatus tyttötutkimukseen / toimittaneet Karoliina Ojanen, Heta Mulari & Sanna Aaltonen. Tampere : Vastapaino, 2011. (Julkaisuja / Nuorisotutkimusverkosto & Nuorisotutkimusseura ; 113)

  12. ITER technology R and D during the EDA

    International Nuclear Information System (INIS)

    Mizoguchi, T.

    2001-01-01

    A short overview of the ITER technology R and D achievements is presented. It includes R and D programme in the area of superconducting magnets, L-1 central solenoid model coil, L-2 toroidal field model coil, L-3 vacuum vessel sector, L-4 blanket module, L-5 divertor cassette, L-6 blanket and L-7 divertor remote handling systems. In addition to the seven large R and D projects, development of components for fuelling, pumping, tritium processing, heating/current drive, power supplies and plasma diagnostics, as well as safety-related R and D have significantly progressed

  13. Esimene supermarket jõudis Eestisse / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Ilmunud ka: Ilmunud ka: Delovõje Vedomosti : Desjatiletnije firmõ 4. veebr. lk. 2. Eesti esimese supermarketi - ETK Maksimarketi äriideest, asutajatest ja avamisest Tallinnas Tihniku tänaval 1994. aastal

  14. "Da Vinci kood" endiselt lahti muukimata / Riho Laurisaar, Eda Post

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2006-01-01

    Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard, produtsent Brian Greiser) on tekitanud aktiivset vastukaja kristlaste ringkondades. Lisatud : "Kirjanik. Dan Brown : usklikust koolipoisist sai väidetav usurüvetaja", "Raamat. Raamatut müüakse endiselt miljonites", "Vastasseis. Usklikud ühinevad "Da Vinci koodi vastu", "Kirjastus. Kohus vabastas Dan Browni plagiaadisüüdistusest", "Reisid. Turismifirmad võtavad graalihulluselt matti"

  15. Mida ootavad noorukid üldhariduskoolilt? / Eda Heinla

    Index Scriptorium Estoniae

    Heinla, Eda, 1953-

    2004-01-01

    2000/2001. õppeaastal 16-17aastaste õpilaste seas tehtud küsitlusest, mille eesmärgiks oli välja selgitada noorte ootused kooli suhtes ja analüüsida õpilaste vaba aja veetmise viise ning huvialadega tegelemise aktiivsust

  16. 4 Channel Digital Down Converter – DDC (EDA-00991)

    CERN Document Server

    BLAS, A; DELONG, J (BNL)

    2012-01-01

    A novel rf beam control architecture has been successfully tested in the LEIR synchrotron. The design is based on a VME 64X carrier board, including a DSP (digital signal processor), into which different daughter cards can be plugged in. The DDC (Digital Down Converter) is one of them. Hardware wise it has the features of a four-channel ADC (analogue-to-digital converter) which outputs drive a powerful FPGA (field programmable logic array); the latter is connected to the DSP on the carrier board via high-speed connectors. Mainly, this unit will acquire rf signals to analyze their phase and amplitude at a specified harmonic of the revolution. The main sampling clock feeding the mezzanine board is at a high harmonic of the particle’s revolution frequency. In the PSB, this frequency is varying along the accelerating cycle and this choice allows analyzing the rf signals from the cavities or from the beam without changing any parameter along the cycle. The sampling clock is tagged at the revolution rate allowing...

  17. Eesti Posti Ida piirkonna keskus tuleb Rakverre / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2005-01-01

    Eesti Posti nõukogu kiitis heaks ettepaneku moodustada kulude kokkuhoiuks olemasoleva kaheteistkümne asemel viis regionaalset juhtimisüksust - Põhja, Ida, Lõuna, Edela ja Lääne. Lisa: Postiregioonid

  18. Šimpans Cheeta avaldas autobiograafia / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    1930-ndate kuulsate Tarzani-filmide ahvist staar Cheeta on praegu ilmselt maailma vanim ahv (76-aastane) ning kirjastus Fourth Estate Ltd ilmutas anonüümse autori raamatu "Me Cheeta: The Autobiography" (336 lk)

  19. Prof. Tiina Kirsi raamatuesitlus Toronto Ülikoolis : uus ingliskeelne raamat eesti naiste elulugudest / Eda Sepp ; fotod: Eda Sepp

    Index Scriptorium Estoniae

    Sepp, Eda

    2004-01-01

    20. mail 2004 toimus Toronto Ülikooli Eesti Õppetooli juures Tiina Ann Kirsi toimetatud ja Tartu Ülikooli väljaandena 2004. a. ilmunud raamatu "She who remembers survives : interpreting Estonian women's post-soviet life stories" esitlus, kus toimetaja andis põhjaliku ülevaate teose olemusest ning eesmärkidest

  20. Kas ravi välismaal on igaühe teoreetiline õigus või praktiline võimalus? Euroopa Parlamendi ja nõukogu direktiivi 2011/24/EL Eesti õigusesse ülevõtmise mudel / Sille Allikmets

    Index Scriptorium Estoniae

    Allikmets, Sille, 1968-

    2014-01-01

    Piiriülese tervishoiuteenuse regulatsiooni arengust Euroopa Liidus. Patsientide varustamine vajaliku teabega, võrdne kohtlemine, eelloa nõue ja ravikulude katmise põhimõtted direktiivi 2011/24/EL alusel

  1. Poolsajandi õnnesoovid Jaak Aaviksoole / Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar...[jt.

    Index Scriptorium Estoniae

    2004-01-01

    Mõtteid Tartu Ülikooli rektorist tema 50. sünnipäeva puhul : Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar, Indrek Reimand, Toomas Kiho, Leelo Kriisa, Peeter Olesk, Risto Tammelo, Birute Klaas, Peeter Saari, Andrus Ansip, Mait Klaassen, Marika Kullamaa, Kaupo Bend

  2. Kaplan kõneles Iraagis rahust / Raivo Nikiforov ; interv. Eda Post

    Index Scriptorium Estoniae

    Nikiforov, Raivo

    2005-01-01

    Tapa väljaõppekeskuse kaplan leitnant Raivo Nikiforov käis Bagdadis Eesti rahuvalvajatele jõulujumalateenistust pidamas ning eestlaste elu jälgimas. Iraagi missioonist, rahuvalvajate elamistingimustest

  3. India äri eripära / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2007-01-01

    India antiikmööblit maale toova ID House juht Jaak Morna kirjeldab isikliku kogemuse kaudu India äritavasid ning töökorraldust. Lisa: India; Indiast saab triljonimajandus; Eesti-India majandussuhted; Kinnisvarahinnad teevad meile silmad ette

  4. Töötervishoid 21 : Kuhu lähed, Eestimaa? / Eda Merisalu

    Index Scriptorium Estoniae

    Merisalu, Eda, 1955-

    2002-01-01

    Symposium in the University of Tartu. Occupational Health 21st century: Where are you going, Estonia? lk. 22.Tartu Ülikool. Arstiteaduskond. Tervishoiu instituut.Töötervishoid 21 : Kuhu lähed, Eestimaa?, sümpoosion (2002 : Tartu)

  5. Tootjad prognoosivad sel aastal suvetoodetele 30% müügikasvu / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Rakvere Lihatööstuse, AS-i Wõro Kommerts, Valga Lihatööstuse ning AS-i Tallegg müügiprognoosid. Kommenteerib Kristel Kindsigo. Lisa: Suurimat kasvu ootab Filee LT. Vt. samas: Kanaliha tarbimine on kahekordistunud

  6. Aasta parim catering-firma le Bonaparte / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Ilmunud ka: Delovõje Vedmosti : Vkus zhizni, 27. okt. 2004, lk. 14-15. Äripäev ja Pernod Ricard Estonia viisid läbi parima catering-firma konkursi. Lisa: 200 krooni eest saab piisavalt süüa. Kommenteerib Imre Kose

  7. Supramolecular Control of Oligothienylenevinylene-Fullerene Interactions: Evidence for a Ground-State EDA Complex

    NARCIS (Netherlands)

    McClenaghan, N.D.; Grote, Z.; Darriet, K.; Zimine, M.Y.; Williams, R.M.; De Cola, L.; Bassani, D.M.

    2005-01-01

    Complementary hydrogen-bonding interactions between a barbituric acid-substituted fullerene derivative (1) and corresponding receptor (2) bearing thienylenevinylene units are used to assemble a 1:1 supramolecular complex ( K ) 5500 M-1). Due to the close proximity of the redox-active moieties within

  8. ITER EDA newsletter. V. 9, no. 10. Special Issue. Outline of the new ITER design

    International Nuclear Information System (INIS)

    2000-10-01

    To identify designs that might meet the revised objectives, task forces involving the JCT and Home Teams met during 1998 and 1999 to analyse and compare a range of options for the design of such a device. Using the common vehicle of system codes to consistently relate the main plasma parameters, physics design constraints, engineering features, and costs, along with more detailed studies of engineering and physics aspects of specific cases, representative options that span an appropriate range of aspect ratio were selected for further elaboration and more comprehensive consideration. This led at the end of 1999 to a single configuration for the ITER design with parameters considered to be the most credible consistent with technical limitations and the financial target, yet meeting fully the objectives with appropriate margins

  9. Engineering Design Activities (EDA) of the International Thermonuclear Experimental Reactor (ITER) Project: January 1993 progress report

    International Nuclear Information System (INIS)

    Rebut, P.H.

    1994-01-01

    The task of selecting and assembling the Joint Central Team (JCT) is the authors top priority, and he has instructed the Deputy Directors and Division Heads to diligently pursue the selection of qualified team members. Several steps are involved in assembling the JCT: specification of posts, nomination of candidates, selection of team members, arrival and startup of work, and completion of secondment procedures. Only after these steps have been completed are staff able to take up their full responsibilities within the management structure of the JCT. Even then, a period of some months of acclimatization and adjustment may be required before the staff can be expected to work fully effectively

  10. Fazer tahab kaaperdada Eesti Pagari tuntuimat kaubamärki / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    Oy Karl Fazer Ab esitas patendiametile taotluse uute kaubamärkide registreerimiseks, mis on aga väga sarnased Eesti Pagari Õnne sarja toodete pakenditel olevate kujunditega ja mille värvikombinatsioonid langevad toonide lõikes kokku

  11. Improvisatsioonil põhinev action-teater otsib Rakverest etenduseks talente / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2005-01-01

    A-teatri asutajad tegelevad noorteetenduse jaoks sobivate noorte näitlejate leidmisega, et suvel lavastada action-teatri vormis poolimprovisatsiooniline noortetükk. Teatritegijad Rakveres castingul "Action minu sees"

  12. Royal Service tegutseb üheksas riigis / Paavo Pilv ; interv. Eda-Liis Kann

    Index Scriptorium Estoniae

    Pilv, Paavo

    2004-01-01

    Äripäeva üritusturundusfirmade TOP-is I koha saavutanud Royal Service-i juht ettevõtte edukuse põhjustest, olulisematest töödest 2003. aastal, üritusturunduse tulevikutrendidest ja EL-iga liitumise mõjust valdkonna arengule

  13. Royal Service on Eesti mainekaim üritusturundusfirma / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    Turu-uuringute AS-i korraldatud üritusturunduse ettevõtete maineuuringust selgus, et kõige mainekamad Eestis on Royal Service, Event Masters, Broadline ja Sinine Elevant. Kõige madalama mainega on Tequila

  14. Andrzej Wajda : maailm küll teadis, aga ei hoolinud / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    Poola filmi- ja teatrilavastaja Andrzej Wajda, kes pälvis sel aastal president Toomas Hendrik Ilveselt Maarjamaa Risti III klassi teenetemärgi. Tema viimasest mängufilmist "Katõn". Lisatud andmed elu ja töö kohta. Ordenit vastu võtma A. Wajda ei tule, sest 24. veebruaril 2008 läheb ta Los Angeleses Oscarite galale, kus tema film "Katõn" on parima võõrkeelse filmi auhinna nominent

  15. Ajaleheturul on 70% allahindlus igapäevane / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Selle asemel, et ametlikult reklaamihinda langetada pakuvad ajalehed reklaamiandjatele ülisuuri soodustusi. Kommenteerivad Enn Parel, Aavo Kokk, Andrus Vaher, Priit Leito, Erik Roose, Ruta Kallaspoolik, Toomas Tiivel, Lauri-Hillar Talve

  16. PR-teenuse hind tõuseb 20% / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Suhtekorraldusfirmad prognoosivad aasta teiseks pooleks PR-teenuste 20protsendilist hinnatõusu. Kommenteerivad Kersti Luha, Maren Pärn, Ingrid Eha, Maria Raudsepp, Heidi Pihlak ja Rein Meripõld. Lisa: Väikefirmale on PR-teenus kallis

  17. SOA and EDA: a comparative study - similarities, difference and conceptual guidelines on their usage

    NARCIS (Netherlands)

    Allah Bukhsh, Zaharah; van Sinderen, Marten J.; Singh, Prince Mayurank

    2015-01-01

    Changing business requirements and new technologies trigger the business stakeholders to shift their approach from many small isolated systems to a single connected system. Integration of isolated systems is partially supported by service oriented architecture (SOA) and event driven architecture

  18. Mayeri Industries plaanib aastaga käibe kahekordistada / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    Eesti oma pesupulbritootja on oma tootmismahte neljakordistanud ja eesmärgiks on suurendada müüki veelgi ning seda allahanke korras jaebrändide alla kuuluvate toodetega. Lisa: Mayeril on seljataga 80 tegevusaastat

  19. Balti kunstnike näitus AABS-i konverentsil : Tulving, Tamasauskas, Ingelevics / Eda Sepp

    Index Scriptorium Estoniae

    Sepp, Eda

    2004-01-01

    Tartu College'i saalis Torontos on 3. - 6. juunini 2004 avatud kunstinäitus, kus saab vaadata Rutt Tulvingu serigraafiasarja "What is Man", välisleedulase Otis Tamasauskase suuremõõtmelist graafikat ning välislätlase Ingelevicsi videoinstallatsiooni

  20. Eraterritooriumile tunginud telekaamera juhmistab ettevõtted / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    Info-Auto juht Viktor Siilats, Kanal 2 peadirektor Urmas Oru ja suhtekorraldusfirma In Nomine juht Heikki Sal-Saller eraettevõtete territooriumil filmimisest ja firma esindajate suhtlemisest ajakirjandusega juhtumi põhjal, kus Silber Auto teenindusega rahulolematu klient püüdis probleemi lahendada Kanal 2 vahendusel. Lisa: Avalikkusele esineb üks inimene. Kommenteerivad Nordic Foodsi juhatuse esimees Kuldar Leis ja In Nomine juht Heikki Sal-Saller

  1. Sotsiaalsed probleemid Eesti ühiskonnas - meeste ja naiste hinnangud 1993. ja 1998. aastal / Eda Heinla

    Index Scriptorium Estoniae

    Heinla, Eda, 1953-

    2001-01-01

    Uurimusest, mille andmestik pärineb TPÜ Rahvusvaheliste ja Sotsiaaluuringute Instituudi perekonnasotsioloogide poolt 1993. ja 1998.a. läbi viidud elanikkonnaküsitlustest "Eesti 93" ja "Eesti 98", kus ühe bloki moodustas sotsiaalsete probleemide küsimustik

  2. Natura toob maaga muret / Eda Post, Marko Püüa

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2004-01-01

    Sadade maaomanike elu muutub pärast Natura 2000 kaitsealade kinnitamist, sest see toob kaasa tegevuspiirangud. Riigi poolt pakutav võimalus maa asendada võtab aga aega ja pakutav tükk võib asuda teises Eesti otsas

  3. Effect of eda loss of function on upper jugal tooth morphology

    Czech Academy of Sciences Publication Activity Database

    Charles, C.; Pantalacci, S.; Peterková, Renata; Tafforeau, P.; Laudet, V.; Viriot, L.

    2009-01-01

    Roč. 292, č. 2 (2009), s. 299-308 ISSN 1932-8486 R&D Projects: GA ČR GA304/05/2665; GA MŠk OC B23.002 Institutional research plan: CEZ:AV0Z50390512 Keywords : dentition * jugal teeth * morphology Subject RIV: FF - HEENT, Dentistry Impact factor: 1.490, year: 2009

  4. Paldisklased said USA mereväelt tasuta arstiabi / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2002-01-01

    Kriisimeditsiiniõppuseks Tallinna sõitnud USA mereväe hospidalilaevas Comfort saavad erialast väljaõpet 245 meedikut ning tasuta hambaravi ja nägemise kontrolli üle poolesaja vähekindlustatud Paldiski elaniku

  5. Synthesis and Layout of an Asynchronous Network-on-Chip using Standard EDA Tools

    DEFF Research Database (Denmark)

    Müller, Christoph; Kasapaki, Evangelia; Sørensen, Rasmus Bo

    2014-01-01

    is the key role that clock signals play in specifying time-constraints for the synthesis. In this paper explain how we handled the synthesis and layout of an asynchronous network-on-chip for a multi-core platform. Focus is on the design process while the actual NOC-design and its performance are presented...

  6. 74 Music as Edae: The Implications for Music Therapy in Nigeria ...

    African Journals Online (AJOL)

    Ike Odimegwu

    keep the body healthy, if mental health is not maintained, the nervous system is ... table for 'exercises for exercises' sake, music in Nigeria being an eclectic art form ... China, India, Egypt, Greece, Rome, Africa, America, all had civilizations that ...

  7. 76 FR 12616 - Request for Comments: Review and Improvement of EDA's Regulations

    Science.gov (United States)

    2011-03-08

    ... particular input on those regulations that impact the creation and growth of Regional Innovation Clusters... DEPARTMENT OF COMMERCE Economic Development Administration 13 CFR Chapter III [Docket No...: Economic Development Administration, Department of Commerce. ACTION: Notice and request for comments...

  8. 75 FR 16739 - EDA Participation in the Energy Efficient Building Systems Regional Innovation Cluster Initiative

    Science.gov (United States)

    2010-04-02

    ...: Promote regional development; Accelerate innovation, technology transfer, and entrepreneurship to create... priorities, which are: Collaborative Regional Innovation. Initiatives that support the development and growth... Participation in the Energy Efficient Building Systems Regional Innovation Cluster Initiative AGENCY: Economic...

  9. Feature selection for splice site prediction: A new method using EDA-based feature ranking

    Directory of Open Access Journals (Sweden)

    Rouzé Pierre

    2004-05-01

    Full Text Available Abstract Background The identification of relevant biological features in large and complex datasets is an important step towards gaining insight in the processes underlying the data. Other advantages of feature selection include the ability of the classification system to attain good or even better solutions using a restricted subset of features, and a faster classification. Thus, robust methods for fast feature selection are of key importance in extracting knowledge from complex biological data. Results In this paper we present a novel method for feature subset selection applied to splice site prediction, based on estimation of distribution algorithms, a more general framework of genetic algorithms. From the estimated distribution of the algorithm, a feature ranking is derived. Afterwards this ranking is used to iteratively discard features. We apply this technique to the problem of splice site prediction, and show how it can be used to gain insight into the underlying biological process of splicing. Conclusion We show that this technique proves to be more robust than the traditional use of estimation of distribution algorithms for feature selection: instead of returning a single best subset of features (as they normally do this method provides a dynamical view of the feature selection process, like the traditional sequential wrapper methods. However, the method is faster than the traditional techniques, and scales better to datasets described by a large number of features.

  10. 4 Channel Slave Direct-Digital-Synthesizer – SDDS (EDA-00992)

    CERN Document Server

    BLAS, A; DELONG, J

    2011-01-01

    A novel rf beam control architecture has been successfully tested in the LEIR synchrotron. The design is based on a VME 64X carrier board, including a DSP (digital signal processor), into which different daughter cards can be plugged in. The SDDS (Slave Direct Digital Synthesizer) is one of them. Hardware wise it has the features of a four-channel DAC (digital-to-analogue converter) which inputs are driven by a powerful FPGA (field programmable logic array); the latter is connected to the DSP on the carrier board via high-speed connectors. Mainly, this unit will supply the rf signals driving the cavities at a specified harmonic of the revolution. The main sampling clock feeding the mezzanine board is at a high harmonic of the particle’s revolution frequency. In the PSB, this frequency is varying along the accelerating cycle and this choice allows creating the rf signal feeding the accelerating cavities without changing any parameter along the cycle. The sampling clock is tagged at the revolution rate allowi...

  11. Pension on mesi vanaduspäevil / Toomas Lumi ; interv. Eda Post

    Index Scriptorium Estoniae

    Lumi, Toomas

    2004-01-01

    Ühispanga Rakvere kontoris töötav parim pensioni teise samba müüja Toomas Lumi ennustab, et pärast teise pensionisambaga liitumise buumi lõppu hakatakse rohkem tähelepanu pöörama kolmandale sambale

  12. USA kohus keelas "Kuristik rukkis" järje avaldamise / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2009-01-01

    J. D. Salinger saavutas võidu rootslase Frederik Coltingi üle, kes kirjutas pseudonüümi J. D. California all Salingeri teosele "Kuristik rukkis" järje pealkirjaga "60 Years Later : Coming Through the Rye". Ameerika Ühendriikide kohus keelas raamatu avaldamise ühendriikides

  13. The engineering design evolution of IFMIF: From CDR to EDA phase

    Energy Technology Data Exchange (ETDEWEB)

    Pérez, Mario, E-mail: mario.perez@ifmif.org

    2015-10-15

    Highlights: • Brief description of International Fusion Materials Irradiation Facility (IFMIF), its background and scope its Engineering Design and Validation Activities (EVEDA) phase. • Description and justification of the main design evolutions from previous phases; and in particular from the baseline described in the “Comprehensive Design Report” (CDR). - Abstract: The International Fusion Materials Irradiation Facility (IFMIF), presently in its Engineering Design and Engineering Validation Activities (EVEDA) phase, started in 2007 under the framework of the Broader Approach (BA) Agreement between Japanese Government and EURATOM. The mandate assigned was to develop an integrated engineering design of IFMIF together with accompanying sub-projects to validate the major technological challenges that included the construction of either full scale prototypes or cleverly devised scaled down facilities, which are essential to reliably face the construction of IFMIF on schedule and cost. The Engineering Design Activities were accomplished on-schedule with the release of its “Intermediate Engineering Design Report (IIEDR)” in June 2013 compliant with our mandate. This paper highlights the design improvements implemented from the previous Conceptual Design Phase.

  14. TÜ, TPÜ ja EHI uusi magistreid / Eda Tursk, Hille Roots, Heidi Meier

    Index Scriptorium Estoniae

    Tursk, Eda

    2004-01-01

    Tartu ülikooli eesti ja soome-ugri keeleteaduse osakonnas ning kirjanduse ja rahvaluule osakonnas kaitsesid 2003.a. magistritööd Niina Aasmäe, Piret Voll, Larissa Degel, Reet Hendrikson, Tiina Pai, Petar Kehayov, Anna Baidullina, Katrin Ennus, Kristi Jõesaar, Ell Vahtramäe, Lauri Sommer, Andreas Kalkun, Mirjam Hinrikus, Kristel Nõlvak. Tallinna Pedagoogikaülikoolis kaitsesid 2003.a. magistritööd Sirje Nootre, Merike Mägedi, Tiiu Koovit, Heidi Meier, Jaanika Stackhouse, Lilian Ossi, Annika Vamper, Marika Mikkor, Piret Õunapuu, Helin Puksand, Taimi Rosenberg. Eesti Humanitaarinstituudis kaitses 2003.a. magistritööd Merilin Miljan

  15. Kolm ühes : uhke kirik, võimla ja kontserdisaal / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2009-01-01

    Rakvere Pauluse kiriku (arhitekt Alar Kotli, 1930-ndate 2. pool) Arvo Pärdi nimeliseks muusikamajaks rekonstrueerimise ja Vabaduse väljaku planeerimise rahvusvahelisest arhitektuurivõistlusest, võidutööst "Tintin'na.buli", mille autorid on Kristiina Aasvee, Kristiina Hussar ja Anne Kose OÜ-st Celander Projekt. 2. koha sai töö "Hortus Musicus", mille autorid on Emil Urbel ja Aleksandr Zverev arhitektuuribüroost Emil Urbel OÜ

  16. International Thermonuclear Experimental Reactor (ITER). Engineering Design Activities (EDA). Agreement and protocol 1

    International Nuclear Information System (INIS)

    1992-01-01

    This document contains protocol 1 to the agreement among the European Atomic Energy Community, the government of Japan, the Government of the Russian Federation, and the Government of the United States of America on cooperation in the engineering design activities for the International Thermonuclear Experimental Reactor, which activities shall be conducted under the auspices of the International Atomic Energy Agency

  17. Mitmest pilvelõhkujast piisab 9/11 mälestamiseks? / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2009-01-01

    New Yorgis terroristide hävitatud Maailma Kaubanduskeskuse kaksiktornide alale uue projekti leidmiseks korraldatud võistlusel valiti 2003. a. välja arhitekt Daniel Libeskindi kavand "Memory Foundation", mis nägi ette mälestuskompleksi hukkunutele tornide asukohas ja selle ümber viie uue pilvelõhkuja ehitamise. Tornid projekteerisid David Childs, Norman Foster, Richard Rogers, Fumihiko Maki ja arhitektuuribüroo Kohn Pedersen Fox. Valminud on torn Seitse, 2006. a. algas ehitus peaväljakul. Vaidlusest selle üle, kas on mõistlik viis torni välja ehitada

  18. Võitlev raamatukogutöötaja ja radikaalne uuendaja John Cotton Dana / Eda Pihu

    Index Scriptorium Estoniae

    Pihu, Eda

    2010-01-01

    Dana on ajalukku läinud avariiulite loojana, laste- ja äriraamatukogudele alusepanijana, reklaami kasutajana raamatukogude propageerimisel ühiskonnas ja lugemisharjumuste edendajana. Lisa: John Cotton Dana 12 kuulsat lugemise reeglit

  19. Tervise edendamine ja kvaliteedi tagamine Eesti haiglates / Kaja Põlluste, Jane Alop, Eda Merisalu...[jt.

    Index Scriptorium Estoniae

    2006-01-01

    1990ndate aastate keskel algatati Maailma Terviseorganisatsiooni eestvedamisel tervist edendavate haiglate (TEH) liikumine. TEH-võrgustikuga ühinenud ja võrgustikku mittekuuluvate Eesti haiglate tegevusest tervise edendamisel ja tervishoiuteenuste kvaliteedi tagamisel. Lisatud statistilised tabelid ja diagrammid

  20. Via media äri rajaneb kolmel vaalal / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    Meediaagentuuri Via Media reklaamikäive kasvas 2004. aastal 59 miljonilt kroonilt 74 miljonile kroonile, äriedu tugineb kolmele suurkliendile - EMT, L'Oreal ja Unilever. Kommenteerivad Media House'i arendusjuht Raido Raamat, Trendmark OÜ tegevdirektor Janeck Uibo, Agne Vilt (Via Media) ja Oliver Vilms (Creative Media Service). Tabelid: Meediaagentuuride TOP 10; Meediaagentuuride käibe kasvu TOP 10

  1. Update Strength in EDAs and ACO: How to Avoid Genetic Drift

    DEFF Research Database (Denmark)

    Sudholt, Dirk; Witt, Carsten

    2016-01-01

    , showing that the update strength should be limited to 1/K, ρ = O(1/(√n log n)). In fact, choosing 1/K, ρ ∼ 1/(√n log n) both algorithms efficiently optimize OneMax in expected time O (n log n). Our analyses provide new insights into the stochastic behavior of probabilistic model-building GAs and propose...

  2. Tornid, millest pilved jäävad allapoole / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    Maailma kõrgeimatest hoonetest alates Frank Lloyd Wrighti kavandatud tornist The Illinois. Burj Dubai ja Al Burj Araabia Ühendemiraatides, Abraj Al Bait Saudi Araabias, Chicago Spire (arhitekt Santiago Calatrava) ja Moskva rahvusvahelise ärikeksuse torn (Briti arhitektuuribüroo Foster and Partners)

  3. Eesti läheb Riia saatkonna ehitusega teisele katsele / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    Riia Eesti suursaatkonnahoone arhitektuurikonkursist. Esikoha pälvisid Lembit-Kaur Stöör, Ülo-Tarmo Stöör ja Heidi Urb (võistlustöö "Teele"), teise koha saavutasid Emil Urbel, Andrus Mark, Ott Hirvesoo ja Peeter Veimer ("Horta"), kolmanda koha Juris Mitenbergs, Peteris Suprins, Zane Krumina, Uldis Tucs, Edgars Gribusts ja Edijs Kravalis ("White Cube.ee)

  4. Balti Töötervishoiu & Tööohutuse Selts (BTTS) = Baltic Occupational Health & Safety Society / Eda Merisalu

    Index Scriptorium Estoniae

    Merisalu, Eda, 1955-

    2005-01-01

    Balti Töötervishoiu & Tööohutuse Seltsi eesmärgiks on riikidevahelise töötervishoiualse koostöö edendamine Balti regioonis, rahvusvaheliste koolitusprogrammide ja rakendusuuringute arendamine

  5. Klaaspudelist loobumine vähendab Coca-Cola brändi eeliseid / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    BRAND sense uuringu kohaselt, milles uuriti pakendi mõju brändilojaalusele, eelistab enam kui 60% Ameerika ja Suurbritannia tarbijaist juua kokakoolat klaaspudelist. Majanduslikel põhjustel on Coca-Cola Company aga viimased kümme aastat tegelenud klaaspudelite poelettidelt ära korjamisega. Diagramm

  6. Kõik üritused on show'd / Jüri Peetson ; interv. Eda-Liis Kann

    Index Scriptorium Estoniae

    Peetson, Jüri

    2005-01-01

    Üritusturunduse TOP-is I ja II kohta jagava PNG juht vastab küsimustele, mis puudutavad spordiürituste korraldamist, läbiviidud üritusi, üritusturundusfirmade ülesandeid suve- ja talvepäevadel, erinevust võrreldes teiste üritusturundusega tegelevate ettevõtetega, suurimat koostööpartnerit. Lisa: Üritusturunduse ettevõtete TOP 10

  7. Avenüüle tõi edu kindla nishi hoidmine / Merike Reino ; interv. Eda-Liis Kann

    Index Scriptorium Estoniae

    Reino, Merike

    2005-01-01

    Ajakirja Avenüü tegevjuht ajakirja käibe kasvust, laienemisest Lätisse, konkurentsist Eestis ja Lätis, allahindlustest reklaamiklientidele. Kommenteerib Media House'i juht Hanno Kindel. Tabel: Ajakirjade reklaamikäibe TOP 10. Vt. samas: Kroonika on ajakirjade lipulaev

  8. Biosignals reflect pair-dynamics in collaborative work: EDA and ECG study of pair-programming in a classroom environment.

    Science.gov (United States)

    Ahonen, Lauri; Cowley, Benjamin Ultan; Hellas, Arto; Puolamäki, Kai

    2018-02-16

    Collaboration is a complex phenomenon, where intersubjective dynamics can greatly affect the productive outcome. Evaluation of collaboration is thus of great interest, and can potentially help achieve better outcomes and performance. However, quantitative measurement of collaboration is difficult, because much of the interaction occurs in the intersubjective space between collaborators. Manual observation and/or self-reports are subjective, laborious, and have a poor temporal resolution. The problem is compounded in natural settings where task-activity and response-compliance cannot be controlled. Physiological signals provide an objective mean to quantify intersubjective rapport (as synchrony), but require novel methods to support broad deployment outside the lab. We studied 28 student dyads during a self-directed classroom pair-programming exercise. Sympathetic and parasympathetic nervous system activation was measured during task performance using electrodermal activity and electrocardiography. Results suggest that (a) we can isolate cognitive processes (mental workload) from confounding environmental effects, and (b) electrodermal signals show role-specific but correlated affective response profiles. We demonstrate the potential for social physiological compliance to quantify pair-work in natural settings, with no experimental manipulation of participants required. Our objective approach has a high temporal resolution, is scalable, non-intrusive, and robust.

  9. Müügimeeskond tundku kampaaniat läbi ja lõhki / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 15. aug. lk. 14. Sisekommunikatsiooni osatähtsusest ettevõttes. Oma töötajad on enamasti parim võimalus selgitada, kas plaanitav kampaania on arusaadav ja vajalik. Kommenteerib Elisabeth Milton Hemmingsen. Lisa: Taust

  10. 75 FR 23676 - Solicitation of Applications for the i6 Challenge Under EDA's Economic Adjustment Assistance Program

    Science.gov (United States)

    2010-05-04

    ... increase and accelerate technology commercialization in regions across the United States. Applicants are... or entity, including, but not limited to, entrepreneurs, universities, SBIR Grantees, foundations, or... government agencies; A clear understanding of the challenges facing the region's entrepreneurs and innovators...

  11. Kui kunst jäljendab elu : meetodi hullumeelne maailm / John Hiscock ; tõlk. Eda Post

    Index Scriptorium Estoniae

    Hiscock, John

    2006-01-01

    Lee Strasbergi poolt populariseeritud Stanislavskilik "meetodnäitlemine" filmides "Tramm nimega Iha", "The Hustler", "Withnail ja mina", "Bridget Jonesi päevik", "Carrie", "Raevunud härg", "Maratoonar", "Aviaator", "Hullusärk"

  12. The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors

    Czech Academy of Sciences Publication Activity Database

    Peterková, Renata; Lesot, H.; Viriot, L.; Peterka, Miroslav

    2005-01-01

    Roč. 50, - (2005), s. 219-225 ISSN 0003-9969 R&D Projects: GA MŠk OC B23.002; GA ČR GA304/02/0448 Institutional research plan: CEZ:AV0Z5039906 Keywords : supernumerary tooth * molar * odontogenesis Subject RIV: EA - Cell Biology Impact factor: 1.288, year: 2005

  13. Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia.

    Science.gov (United States)

    Podzus, J; Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; Willen, L; Staehlin, G; Vigolo, M; Tardivel, A; Headon, D; Kirby, N; Mikkola, M L; Schneider, H; Schneider, P

    2017-02-01

    The tumor necrosis factor (TNF) family ligand ectodysplasin A (EDA) is produced as 2 full-length splice variants, EDA1 and EDA2, that bind to EDA receptor (EDAR) and X-linked EDA receptor (XEDAR/EDA2R), respectively. Inactivating mutations in Eda or Edar cause hypohidrotic ectodermal dysplasia (HED), a condition characterized by malformations of the teeth, hair and glands, with milder deficiencies affecting only the teeth. EDA acts early during the development of ectodermal appendages-as early as the embryonic placode stage-and plays a role in adult appendage function. In this study, the authors measured EDA in serum, saliva and dried blood spots. The authors detected 3- to 4-fold higher levels of circulating EDA in cord blood than in adult sera. A receptor binding-competent form of EDA1 was the main form of EDA but a minor fraction of EDA2 was also found in fetal bovine serum. Sera of EDA-deficient patients contained either background EDA levels or low levels of EDA that could not bind to recombinant EDAR. The serum of a patient with a V262F missense mutation in Eda, which caused a milder form of X-linked HED (XLHED), contained low levels of EDA capable of binding to EDAR. In 2 mildly affected carriers, intermediate levels of EDA were detected, whereas a severely affected carrier had no active EDA in the serum. Small amounts of EDA were also detectable in normal adult saliva. Finally, EDA could be measured in spots of wild-type adult or cord blood dried onto filter paper at levels significantly higher than that measured in EDA-deficient blood. Measurement of EDA levels combined with receptor-binding assays might be of relevance to aid in the diagnosis of total or partial EDA deficiencies.

  14. Eesti majandust läbiva materjalivoo arvestus = Economy-wide material flow account of Estonia / Eda Grüner

    Index Scriptorium Estoniae

    Grüner, Eda

    2010-01-01

    Materjalipõhiste bilansside põhjal koostatud materjalivoo indikaatorite (kodumaine toormekasutus, ressursitootlikkus ja füüsilise väliskaubanduse bilanss) abil iseloomustatakse Eesti majanduse materjalikasutust ning tootlikkust aastatel 2000-2007. Võrdlus Euroopa Liidu näitajatega. Graafikud, diagrammid

  15. Jaebrändid astuvad üleriigilistele brändidele üha kiiremini kandadele / Eda-Liis Kann

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2004-01-01

    Jaebrändi mõiste ja liikide tutvustus. Oma jaebrändide turule toomisest ja edukusest räägivad Rimi turundusjuht Ruta Kallaspoolik, Selveri ostudirektor Iivi Saar ja Stockmanni ostujuht Marge Türner. Kommenteerib EMORi suunajuht Aivar Voog. Lisa: Private label-tooteid on kolme liiki. Vt. samas: Inglismaal ja Šveitsis 70% private label-tooteid

  16. Efectividad de la administración de sales de rehidratación oral (SRO, en el marco del programa EDA

    Directory of Open Access Journals (Sweden)

    Leonardo Arévalo Mora

    2002-10-01

    Full Text Available Objective: To determine the effectiveness that have the salts of oral rehydration in the patients that with the diagnosis of acute diarrheal disease. Design. Systematic revision of randomized controlled studies. Sources of data: Medline (1966-2001, Cochrane library, (1993 to 2001 and Ovid (1982 to 2001, bibliographies of the included studies that it was revised if this was pertinent Study: 31 studies that included 4518 randomized patients. Methods: The selected studies were regrouped in subgroups by the components that were compared in the intervention. Those which besides the salts of oral rehydration (SRO they included solutions with low osmolarity, based on rice, or with the addition of supplements like citrato, zinc, alanine, lactoalbuline, and g1utamine. Results: A high proportion of studies showed the advantage that shows the salts of oral rehydration recornmended by the World Organization of the Health and the Pan-American Organization from the Health when improving the clinical square of the patients with diagnoses of diarrhea and dehydration. It was evidences a better answer with the SRO of low osmolarity, although not in all the studies it was statistically Significant. Conclusions: This work demonstrated that the salts of oral rehydration reduce the number of depositions, its diminish the time of evolution of the diarrhea, its diminished the rate of mortality, the time of stay in the hospitals, and its cooperated to recover of the state of dehydration and to obtain a gain of weight in the firsts hours. The therapy of oral rehydration is probably one of the biggest medical advances in the XX century.

  17. Muutumismäng 2011. 1.-6. osa / Sille Laidmaa, Leho Säde, Eda Holmberg ... [jt.] ; kommenteerinud Aleksandra Lear, Andres, Barabanov, Maiki Ritslaid ... [jt.

    Index Scriptorium Estoniae

    2012-01-01

    Eksperiment 5 osalejaga, kes kõik soovivad muuta erinevaid füüsilise tervise näitajaid ning kasutavad ka erinevaid treeningviise. Eesti Olümpiakomitee ja ühenduse Sport Kõigile kampaaniast "Eestimaa liigub!", et arendada eestimaalaste liikumisharrastust (nr. 3) Eesti Olümpiakomitee uuendatud kodulehest (6)

  18. Haiglatöötajate rahulolu töökorralduse ja töötingimustega / Kaja Põlluste, Eda Merisalu

    Index Scriptorium Estoniae

    Põlluste, Kaja, 1967-

    2007-01-01

    Aastatel 2004-2006 uuriti neljas Eesti haiglas anonüümse ankeetküsitluse abil töötajate rahulolu oma tööga, töökorralduse, töötingimuste ja töösuhetega. Lisatud statistilised diagrammid ja tabelid

  19. Ocorrência de Passalora bougainvilleae (Muntañola) Castañeda & Braun associado à Bougainvillea spectabilis Willd. em Boa Vista, Roraima

    OpenAIRE

    Nechet,Kátia de Lima; Halfeld-Vieira,Bernardo A.

    2008-01-01

    O fungo Passalora bougainvilleae é relatado, pela primeira vez, na região de Boa Vista, Roraima, associado a manchas foliares na planta ornamental Bougainvillea spectabilis. As características do fungo são conidióforos agregados em fascículos, emergindo de um estroma subcuticular na face abaxial de lesões velhas. Os conidióforos são lisos, retos, de coloração marrom, não ramificados, maioria asseptados, medindo de 26-57µm x 4µm. Células conidiogênicas terminais de proliferação simpodial com c...

  20. Repot of Passalora bougainvilleae (Muntañola) Castañeda & Braun associated with Bougainvillea spectablis Willd. in Boa Vista, Roraima

    OpenAIRE

    Nechet, Kátia de Lima; Halfeld-Vieira, Bernardo A.

    2008-01-01

    O fungo Passalora bougainvilleae é relatado, pela primeira vez, na região de Boa Vista, Roraima, associado a manchas foliares na planta ornamental Bougainvillea spectabilis. As características do fungo são conidióforos agregados em fascículos, emergindo de um estroma subcuticular na face abaxial de lesões velhas. Os conidióforos são lisos, retos, de coloração marrom, não ramificados, maioria asseptados, medindo de 26-57µm x 4µm. Células conidiogênicas terminais de proliferação simpodial com c...

  1. Ragn-Sells jätkab Loode-Eesti prügila projekti / Eda Liiväär

    Index Scriptorium Estoniae

    Liiväär, Eda

    2003-01-01

    Vaatamata Ääsmäe prügila projekti luhtumisele ei ole Rootsi jäätmekäitlusfirma Ragn-Sells loobunud kavast rajada Lääne-Harjumaale oma prügila. Kommentaarid firma arengudirektor Agu Remmelgalt ja Lääne-Harjumaa valdade esindajatelt. Tabel: Jäätmekeskuse ajalugu ja tulevik

  2. 10 aastat Eestis tegutsenud prügifirma Ragn-Sells loodab murda Ääsmäe elanike vastuseisu / Eda Liiväär

    Index Scriptorium Estoniae

    Liiväär, Eda

    2002-01-01

    Ragn-Sells AS-i juhatuse esimees Rein Leipalu ja arendusdirektor Agu Remmelg rääkisid pressihommikul, mis muutub Eesti prügimajanduses EL-iga liitudes ja mis toimub Tallinna prügiäris ning Ääsmäe prügilast

  3. Major achievements of the European shield blanket R and D during the ITER EDA, and their relevance for future next step machines

    Energy Technology Data Exchange (ETDEWEB)

    Daenner, W. E-mail: daenner@ipp.mpg.de; Cardella, A.; Jones, L.; Lorenzetto, P.; Maisonnier, D.; Malavasi, G.; Peacock, A.; Rodgers, E.; Tavassoli, F

    2000-11-01

    In the frame of the international thermonuclear experimental reactors (ITER) collaboration, the European home team (EU HT) has committed significant efforts on the R and D for the Shield Blanket. This paper summarises the main achievements of this programme, which have been obtained over the last 7 years. The depth of R and D extends from generic activities up to the manufacture of prototypes, but has, in accordance with the design progress, reached different stages of maturity for the various components. New ITER options being considered since early 1998 have not made these activities irrelevant. With few exceptions, the results are still applicable for less ambitious next step machines, or transferable to components with similar functions or requirements.

  4. Autoconceito dos professores: principais factores usando modelos de Análise de Dados Multivariada Teachers' self-concept: finding main factors and clusters by EDA models

    Directory of Open Access Journals (Sweden)

    Vitor Franco

    2008-01-01

    Full Text Available O autoconceito tem sido considerado uma dimensão muito importante da personalidade do professor, da sua prática e do seu desenvolvimento pessoal (MARKUS; WURF, 1987; SIMÕES, 2001. A investigação que apresentamos foi efectuada com 281 professores de Ciências da Natureza, do terceiro ciclo do Ensino Básico, em Portugal, usando o ICAC- Inventário Clínico do Auto Conceito (VAZ-SERRA, 1986. Na análise dos dados obtidos foram usados diferentes métodos de Análise Multivariada, apresentando-se os resultados da análise factorial de correspondências e nos modelos de classificação hierárquica baseados no coeficiente de afinidade. Os resultados obtidos: 1 confirmam a importância de dois grandes factores presentes no Autoconceito: aceitação social e auto-eficácia; 2 caracterizam estes principais factores no que se refere ao Autoconceito clínico dos professores; 3 mostram como esses factores são determinantes na forma como cada professor constroi o seu autoconceito.The self-concept has been considered as a very important dimension on teacher's personality, practice and development (MARKUS; WURF, 1987;SIMÕES, 2001. The present research concerns a sample of 281 teachers of Natural Science of the Third Cycle of Basic Education from Portugal that responded to the I.C.A.C. - Self-Concept Clinical Inventory (VAZ-SERRA, 1986. In the analysis of the questionnaires different multivariate data analysis methods have been used. This paper describes some results issued from correspondence analysis and hierarchical clustering models based on the affinity coefficient. The results obtained: 1 confirm the importance of two general main factors / types which are present in self-concept: social acceptance and self-efficiency; 2 characterise these main factors when teachers'clinical self-concept is concerned and 3 show how determinant these factors are for the building of self-concept that allow us to differentiate teachers.

  5. Is it possible to indicate an ''electrosensitivity'' to an 50 Hz-magnetic field with an intensity of 10 {mu}T by the process of electrodermal activity (EDA)?; Laesst sich in der Hautleitfaehigkeit (EDA) bestimmter Menschen eine ''Elektrosensibilitaet'' auf ein 50 Hertz-Magnetfeld mit einer Intensitaet von 10 {mu}T abbilden?

    Energy Technology Data Exchange (ETDEWEB)

    Kaul, G. [Bundesanstalt fuer Arbeitsschutz und Arbeitsmedizin, Berlin (Germany)

    2004-07-01

    The aim of this study is to prove three hypotheses: 1) People who are very susceptible to EMF have a high ability to perceive small differences of stimuli (biological disposition). 2) People who are very susceptible to EMF have a high level of psychological or physiological stress as temporary conditions. 3) People who seem to be very susceptible to EMF have personal problems, and are not able to solve them otherwise (transference in terms of the theory of psychoanalysis). There were 96 volunteers without perception of any EM-field and 24 people with impairments of health on that were examined. Perceptual and mental tasks were used to differentiate individual performances under the influence of a 50 Hz-magnetic field with an intensity of 10 {micro}T. Positive findings may lead to the explanation of other environmental diseases. (orig.)

  6. Ocorrência de Passalora bougainvilleae (Muntañola Castañeda & Braun associado à Bougainvillea spectabilis Willd. em Boa Vista, Roraima Repot of Passalora bougainvilleae (Muntañola Castañeda & Braun associated with Bougainvillea spectablis Willd. in Boa Vista, Roraima

    Directory of Open Access Journals (Sweden)

    Kátia de Lima Nechet

    2008-01-01

    Full Text Available O fungo Passalora bougainvilleae é relatado, pela primeira vez, na região de Boa Vista, Roraima, associado a manchas foliares na planta ornamental Bougainvillea spectabilis. As características do fungo são conidióforos agregados em fascículos, emergindo de um estroma subcuticular na face abaxial de lesões velhas. Os conidióforos são lisos, retos, de coloração marrom, não ramificados, maioria asseptados, medindo de 26-57µm x 4µm. Células conidiogênicas terminais de proliferação simpodial com cicatrizes escuras e pouco espessas. Os conídios são solitários, marrom claro, obclavados, retos a ligeiramente curvos, medindo de 32-70 µm x 4-5 µm, maioria com 3 septos, apresentando um hilo truncado e ápice obtuso.The fungi Passalora bougainvilleae is reported, for the first time, Boa Vista, Roraima state, causing leaf spots on ornamental specie Bougainvillea spectabilis. The fungi characteristics are conidiophores hypophyllous in fascicles arising from the upper cells of a stroma subcuticular at old spots. The conidiphores are smooth, straight, pale brown, non-branched, mostly aseptate, 26-57µm x 4µm. Conidiogenous cells terminal, sympodial with black and thin scars. Conidia solitary, pale brown, obclavate, straight to slightly flexuous, 32-70 µm x 4-5 µm, 3 septate, rounded at apex, truncate at base, with a conspicuous hilum.

  7. ITER council proceedings: 2001

    International Nuclear Information System (INIS)

    2001-01-01

    Continuing the ITER EDA, two further ITER Council Meetings were held since the publication of ITER EDA documentation series no, 20, namely the ITER Council Meeting on 27-28 February 2001 in Toronto, and the ITER Council Meeting on 18-19 July in Vienna. That Meeting was the last one during the ITER EDA. This volume contains records of these Meetings, including: Records of decisions; List of attendees; ITER EDA status report; ITER EDA technical activities report; MAC report and advice; Final report of ITER EDA; and Press release

  8. María Castañeda de la Paz y Hans Roskamp (eds.), Los escudos de armas indígenas. De la Colonial al México Independiente

    OpenAIRE

    Castañeda García, Rafael

    2015-01-01

    El encuentro de dos civilizaciones tuvo entre sus múltiples consecuencias, en el ámbito político y cultural, la fusión del lenguaje heráldico europeo con las insignias militares de origen mesoamericano. El libro que nos reúne en esta ocasión está integrado por diez trabajos de académicos de instituciones de México, Estados Unidos y España, que analizan la importancia de los escudos de armas como símbolos de poder e identidad desde el siglo XVI hasta el siglo XX. Los coordinadores de la obra c...

  9. Uus postimüügikataloog üritab end Eesti turule sisse süüa sõbra soovituste kaudu / Eda-Liis Kann, Tiina Kilkson

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    TNS Emori uuring kinnitab, et kaks kolmandikku Eesti inimestest on valmis tegema sõprade soovitusel olulisi ostuotsuseid. Sellest lähtub ka Eesti ja Läti turule tulnud uus postimüügikataloog Neckermann, kes kasutab oma nn ekspertprogrammis ekspertidena tavalisi inimesi erinevatelt elualadelt. Vt. samas: Naistele meeldib katalooge lapata; Kataloogidele Eestis ruumi jagub; Ellos lõpetas Eestis postimüügi

  10. EDA Çekirdekli Amin, TRIS ve Karboksil Sonlu PAMAM Dendrimerleri Kullanarak Ketoprofenin Çözünürlüğünü Geliştirme

    Directory of Open Access Journals (Sweden)

    Ali Serol ERTÜRK

    2017-10-01

    Full Text Available Steroid olmayan antienflamatuar (NSAİ ilaçlar ağrı kesici, ateş düşürücü ve antiinflamatuar etkilerinden dolayı yaygın bir şekilde kullanılmaktadırlar. Son yıllarda NSAİ ilaçların iyi bilinen klasik etkilerinin yanında birçok farklı terapötik etkilerinin (kanser, Alzheimer ve Parkinson hastalıkları de bulunduğu keşfedilmiştir. Sonuçlar gösteriyor ki, poli(amidoamin (PAMAM dendrimerler varlığında ketoprofen’in (KETO sudaki çözünürlüğü jenerasyon büyüklüğü (E2-E4 ve dendrimer konsantrasyonun (0-2 mM artmasıyla önemli ölçüde geliştirilmiştir. KETO’nun (0.22 ± 0.003 mg/mL çözünürlüğünü arttırmada PAMAM dendrimerlerin rolü E4.TRIS (52.77 ± 2.06 mg/mL> E4.COOH (36.42 ± 0.54 mg/mL> E3.TRIS (13.70 ± 0.17 mg/mL> E3.COOH (11.97 ± 0.14 mg/mL> E4.NH2 (6.53 ± 0.19 mg/mL> E2.COOH (5.95 ± 0.10 mg/mL> E2.TRIS (5.72 ± 0.10 mg/mL> E3.NH2 (4.21 ± 0.04 mg/mL> E2.NH2 (2.35 ± 0.04 mg/mL sırasına göre ve 0.002 M dendrimer varlığında 11 ile 240 kat aralığındadır.

  11. 77 FR 42697 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-07-20

    ... incidental use of property acquired or improved with EDA investment assistance (see 13 CFR 314.3 of EDA... acquired or improved with EDA investment assistance is appropriate. An incidental use of property: (1) Does... the investment assistance, and (3) the incidental use of the property will not violate the terms and...

  12. Epidural Analgesia Versus Patient-Controlled Analgesia for Pain Relief in Uterine Artery Embolization for Uterine Fibroids: A Decision Analysis

    International Nuclear Information System (INIS)

    Kooij, Sanne M. van der; Moolenaar, Lobke M.; Ankum, Willem M.; Reekers, Jim A.; Mol, Ben Willem J.; Hehenkamp, Wouter J. K.

    2013-01-01

    Purpose: This study was designed to compare the costs and effects of epidural analgesia (EDA) to those of patient-controlled intravenous analgesia (PCA) for postintervention pain relief in women having uterine artery embolization (UAE) for systematic uterine fibroids. Methods: Cost-effectiveness analysis (CEA) based on data from the literature by constructing a decision tree to model the clinical pathways for estimating the effects and costs of treatment with EDA and PCA. Literature on EDA for pain-relief after UAE was missing, and therefore, data on EDA for abdominal surgery were used. Outcome measures were compared costs to reduce one point in visual analogue score (VAS) or numeric rating scale (NRS) for pain 6 and 24 h after UAE and risk for complications. Results: Six hours after the intervention, the VAS was 3.56 when using PCA and 2.0 when using EDA. The costs for pain relief in women undergoing UAE with PCA and EDA were €191 and €355, respectively. The costs for EDA to reduce the VAS score 6 h after the intervention with one point compared with PCA were €105 and €179 after 24 h. The risk of having a complication was 2.45 times higher when using EDA. Conclusions: The results of this indirect comparison of EDA for abdominal surgery with PCA for UAE show that EDA would provide superior analgesia for post UAE pain at 6 and 24 h but with higher costs and an increased risk of complications

  13. ITER Council proceedings: 1993

    International Nuclear Information System (INIS)

    1994-01-01

    Records of the third ITER Council Meeting (IC-3), held on 21-22 April 1993, in Tokyo, Japan, and the fourth ITER Council Meeting (IC-4) held on 29 September - 1 October 1993 in San Diego, USA, are presented, giving essential information on the evolution of the ITER Engineering Design Activities (EDA), such as the text of the draft of Protocol 2 further elaborated in ''ITER EDA Agreement and Protocol 2'' (ITER EDA Documentation Series No. 5), recommendations on future work programmes: a description of technology R and D tasks; the establishment of a trust fund for the ITER EDA activities; arrangements for Visiting Home Team Personnel; the general framework for the involvement of other countries in the ITER EDA; conditions for the involvement of Canada in the Euratom Contribution to the ITER EDA; and other attachments as parts of the Records of Decision of the aforementioned ITER Council Meetings

  14. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury

    Directory of Open Access Journals (Sweden)

    Xinhua Zhou

    2015-01-01

    Full Text Available Edaravone (EDA is clinically used for treatment of acute ischemic stroke in Japan and China due to its potent free radical-scavenging effect. However, it has yet to be determined whether EDA can attenuate iodoacetic acid- (IAA- induced neuronal death in vitro. In the present study, we investigated the effect of EDA on damage of IAA-induced primary cerebellar granule neurons (CGNs and its possible underlying mechanisms. We found that EDA attenuated IAA-induced cell injury in CGNs. Moreover, EDA significantly reduced intracellular reactive oxidative stress production, loss of mitochondrial membrane potential, and caspase 3 activity induced by IAA. Taken together, EDA protected CGNs against IAA-induced neuronal damage, which may be attributed to its antiapoptotic and antioxidative activities.

  15. Experiment data acquisition and analysis system. Vol. 1

    International Nuclear Information System (INIS)

    Busch, F.; Croome, D.; Goeringer, H.; Hartmann, V.; Lowsky, J.; Marinescu, D.; Richter, M.; Winkelmann, K.

    1983-08-01

    The Experiment Data Acquisition and Analysis System EDAS was created to acquire and analyze data collected in experiments carried out at the heavy ion accelerator UNILAC. It has been available since 1975 and has become the most frequently used system for evaluating experiments at GSI. EDAS has undergone constant development, and the many enhancements make this completely revised third edition of the EDAS manual necessary. EDAS consists of two sub-systems: GOLDA for experimental data acquisition on PDP-11's and SATAN mainly for off-line analysis in replay mode on large IBM mainframes. The capacity of one IBM 3081 CPU is mainly dedicated to EDAS processing and is almost fully utilized by this application. More than 200 users from GSI as well as from collaborating laboratories and universities use SATAN in more than 100 sessions daily needing 10 to 20 hours of user CPU time. EDAS is designed as an open system. (orig./HSI)

  16. ITER council proceedings: 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    Records of the third ITER Council Meeting (IC-3), held on 21-22 April 1993, in Tokyo, Japan, and the fourth ITER Council Meeting (IC-4) held on 29 September - 1 October 1993 in San Diego, USA, are presented, giving essential information on the evolution of the ITER Engineering Design Activities (EDA), such as the text of the draft of Protocol 2 further elaborated in ``ITER EDA Agreement and Protocol 2`` (ITER EDA Documentation Series No. 5), recommendations on future work programmes: a description of technology R and D tastes; the establishment of a trust fund for the ITER EDA activities; arrangements for Visiting Home Team Personnel; the general framework for the involvement of other countries in the ITER EDA; conditions for the involvement of Canada in the Euratom Contribution to the ITER EDA; and other attachments as parts of the Records of Decision of the aforementioned ITER Council Meetings.

  17. Improving the accuracy of effect-directed analysis: the role of bioavailability.

    Science.gov (United States)

    You, Jing; Li, Huizhen

    2017-12-13

    Aquatic ecosystems have been suffering from contamination by multiple stressors. Traditional chemical-based risk assessment usually fails to explain the toxicity contributions from contaminants that are not regularly monitored or that have an unknown identity. Diagnosing the causes of noted adverse outcomes in the environment is of great importance in ecological risk assessment and in this regard effect-directed analysis (EDA) has been designed to fulfill this purpose. The EDA approach is now increasingly used in aquatic risk assessment owing to its specialty in achieving effect-directed nontarget analysis; however, a lack of environmental relevance makes conventional EDA less favorable. In particular, ignoring the bioavailability in EDA may cause a biased and even erroneous identification of causative toxicants in a mixture. Taking bioavailability into consideration is therefore of great importance to improve the accuracy of EDA diagnosis. The present article reviews the current status and applications of EDA practices that incorporate bioavailability. The use of biological samples is the most obvious way to include bioavailability into EDA applications, but its development is limited due to the small sample size and lack of evidence for metabolizable compounds. Bioavailability/bioaccessibility-based extraction (bioaccessibility-directed and partitioning-based extraction) and passive-dosing techniques are recommended to be used to integrate bioavailability into EDA diagnosis in abiotic samples. Lastly, the future perspectives of expanding and standardizing the use of biological samples and bioavailability-based techniques in EDA are discussed.

  18. Scutellarin-graft cationic β-cyclodextrin-polyrotaxane: Synthesis, characterization and DNA condensation

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Qi; Ma, Xue; Liao, Xiali; Yang, Bo, E-mail: yangbo6910@sina.com

    2017-02-01

    As a prerequisite of gene delivery in living cells, DNA condensation has attracted more and more attention. In order to improve the efficiencies of polyamine-β-cyclodextrin-based cationic polyrotaxanes (PR-EDA and PR-DETA) as DNA condensation materials, we have designed and prepared two novel scutellarin-grafted cationic polyrotaxanes (PR-EDA-SCU and PR-DETA-SCU), in which scutellarins (SCU), the planar molecules, were conjugated on the cyclodextrin molecules of PR-EDA and PR-DETA. These materials were characterized by 1D and 2D NMR, XRD, TG and DSC. The electrophoresis assays showed that pDNA condensation efficiencies of PR-EDA and PR-DETA were better than that of PR-EDA and PR-DETA. The complexes of PR-EDA, PR-DETA, PR-EDA-SCU and PR-DETA-SCU with pDNA were further investigated by zeta potential and atomic force microscopy analysis. The results indicated that the planar structure of SCU played an important role in improvement of pDNA condensation efficiencies of PR-EDA-SCU and PR-DETA-SCU. The satisfactory pDNA condensation abilities of PR-EDA-SCU and PR-DETA-SCU could be helpful in designing non-viral gene delivery vectors to control gene expression and delivery. - Highlights: • Scutellarin-graft cationic cyclodextrin-polyrotaxans were prepared and characterized. • Scutellarin-graft cationic cyclodextrin-polyrotaxans was abbreviated as PR-(D)EDA-SCU. • The Scutellarin of PR-(D)EDA-SCU may be helpful to DNA condensation. • This study opens new avenues for preparing non-viral gene delivery vectors.

  19. TGFβ1-mediated expression and alternative splicing of Fibronectin Extra Domain A in human podocyte culture.

    Science.gov (United States)

    Madne, Tarunkumar Hemraj; Dockrell, Mark Edward Carl

    2018-02-28

    Alternative splicing is a fundamental phenomenon to build protein diversity in health and diseases. Extra Domain A+ Fibronectin (EDA+Fn) is an alternatively spliced form of fibronectin protein present in the extra cellular matrix (ECM) in renal fibrosis. Podocytes are spectacular cell type and play a key role in filtration and synthesise ECM proteins in renal physiology and pathology. TGFβ1 is a strong stimulator of ECM proteins in renal injury. In this study, we have investigated alternative splicing of EDA+ Fn in human podocytes in response to TGFβ1. We have performed western blotting and immunofluorescence to characterise the expression of the EDA+Fn protein, real-time PCR for RNA expression and RT-PCR to look for alternative splicing of EDA+Fn in conditionally immortalised human podocytes culture.We used TGFβ1 as a stimulator and SB431542 and SRPIN340 for inhibitory studies. In this work, for the first time we have demonstrated in human podocytes culture EDA+Fn is expressed in the basal condition and TGFβ1 2.5ng/ml induced the Fn mRNA and EDA+Fn protein expression demonstrated by real-time PCR, western blotting and immunofluorescence. TGFβ1 2.5ng/ml induced the alternative splicing of EDA+Fn shown by conventional RT-PCR. Studies with ALK5 inhibitor SB431542 and SRPIN340 show that TGFβ1 induced alternative splicing of EDA+Fn was by the ALK5 receptor and the SR proteins.  In human podocytes culture, alternative splicing of EDA+Fn occurs at basal conditions and TGFβ1 further induced the alternative splicing of EDA+Fn via ALK5 receptor activation and SR proteins. This is the first evidence of basal and TGFβ1 mediated alternative splicing of EDA+Fn in human podocytes culture.

  20. Lower Electrodermal Activity to Acute Stress in Caregivers of People with Autism Spectrum Disorder: An Adaptive Habituation to Stress

    Science.gov (United States)

    Ruiz-Robledillo, Nicolás; Moya-Albiol, Luis

    2015-01-01

    Caring for a relative with autism spectrum disorder (ASD) entails being under chronic stress that could alter body homeostasis. Electrodermal activity (EDA) is an index of the sympathetic activity of the autonomic nervous system related to emotionality and homeostasis. This study compares EDA in response to acute stress in the laboratory between…

  1. Selective C--C coupling of ir-ethene and ir-carbenoid radicals

    NARCIS (Netherlands)

    Dzik, W.I.; Reek, J.N.H.; de Bruin, B.

    2008-01-01

    The reactivity of the paramagnetic iridium(II) complex [IrII(ethene)(Me3tpa)]2+ (1) (Me3tpa=N,N,N-tris(6-methyl-2-pyridylmethyl) amine) towards the diazo compounds ethyl diazoacetate (EDA) and trimethylsilyldiazomethane (TMSDM) was investigated. The reaction with EDA gave rise to selective CC bond

  2. 13 CFR 302.19 - Indemnification.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Indemnification. 302.19 Section 302.19 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... permitted by law, a Recipient shall indemnify and hold EDA harmless from any liability that EDA may incur...

  3. Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the USEPA Effluent Testing Program

    Science.gov (United States)

    As part of its whole effluent testing program, the USEPA developed an effects-directed analysis (EDA) approach to identifying the cause of toxicity in toxic effluents or ambient waters, an EDA process termed a “Toxicity Identification Evaluation” (TIE), which is the focus of this...

  4. Exonization of a LINE1 fragment implicated in X-linked hypohidrotic ectodermal dysplasia in cattle

    DEFF Research Database (Denmark)

    Karlskov-Mortensen, Peter; Cirera Salicio, Susanna; Nielsen, Ole Lerberg

    2011-01-01

    A case of X-linked hypohidrotic ectodermal dysplasia (XHED) was identified in a family of Danish Red Holstein cattle. The ectodysplasin-signalling protein (EDA) is known to be central in the normal development of ectodermal structures, and mutations in the ectodysplasin A (EDA) gene have been rep...

  5. Development of the Exams Data Analysis Spreadsheet as a Tool to Help Instructors Conduct Customizable Analyses of Student ACS Exam Data

    Science.gov (United States)

    Brandriet, Alexandra; Holme, Thomas

    2015-01-01

    The American Chemical Society Examinations Institute (ACS-EI) has recently developed the Exams Data Analysis Spread (EDAS) as a tool to help instructors conduct customizable analyses of their student data from ACS exams. The EDAS calculations allow instructors to analyze their students' performances both at the total score and individual item…

  6. Carbon nanotubes with silver nanoparticle decoration and conductive polymer coating for improving the electrical conductivity of polycarbonate composites

    KAUST Repository

    Patole, Archana S.; Lubineau, Gilles

    2015-01-01

    in achieving a uniform dispersion of the Ag/MWCNT-EDA and (2) it acts as a conductive bridge between particles (Ag and MWCNT-EDA), reducing the particle to particle resistivity. When inserted into polycarbonate, this three-phase blend successfully reduced

  7. Ado Vabbe preemia Anne Parmastole

    Index Scriptorium Estoniae

    2003-01-01

    Tartu Kunstimajas Tartu kunsti aastalõpunäitus. Kujundaja Mari Nõmmela. Anne Parmastole A. Vabbe, Silja Salmistule E-Kunstisalongi, Lii Jürgensonile EDA, Jüri Marranile Wilde kohviku, Sami Makkonenile AS Vunder ja Tartu Õlletehase A. Le Coq ning Eda Lõhmusele AS Merko Tartu preemia

  8. Effect-Directed Analysis to Explore the Polar Bear Exposome: the Identification of Thyroid Hormone Disrupting Compounds in Plasma

    NARCIS (Netherlands)

    Simon, E.; van Velzen, M.J.M.; Brandsma, S.H.; Lie, E.; Loken, K.; de Boer, J.; Bytingsvik, J.; Jenssen, B.M.; Aars, J.; Hamers, T.; Lamoree, M.H.

    2013-01-01

    Compounds with transthyretin (TTR)-binding potency in the blood plasma of polar bear cubs were identified with effect-directed analysis (EDA). This approach contributes to the understanding of the thyroid disrupting exposome of polar bears. The selection of these samples for in-depth EDA was based

  9. 75 FR 8648 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-02-25

    ... chapter 4 of the Trade Act of 1974. Affected Public: City, county, or other political subdivision of a...: Economic Development Administration (EDA). Title: Application for Investment Assistance. OMB Control Number... programmatic requirements contained in EDA's authorizing legislation, the Public Works and Economic Development...

  10. ITER management advisory committee meeting

    International Nuclear Information System (INIS)

    Yoshikawa, M.

    2001-01-01

    The ITER Management Advisory Committee (MAC) Meeting was held on 23 February in Garching, Germany. The main topics were: the consideration of the report by the Director on the ITER EDA Status, the review of the Work Programme, the review of the Joint Fund, the review of a schedule of ITER meetings, and the arrangements for termination and wind-up of the EDA

  11. El ecosistema pedagógico de los PLEs

    OpenAIRE

    Adell, Jordi; Castañeda Quintero, Linda Johanna

    2013-01-01

    Para citar: Adell, J. y Castañeda, L. (2013). El ecosistema pedagógico de los PLEs. En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 29-51). Alcoy: Marfil.

  12. Adaptive Variance Scaling in Continuous Multi-Objective Estimation-of-Distribution Algorithms

    NARCIS (Netherlands)

    P.A.N. Bosman (Peter); D. Thierens (Dirk); D. Thierens (Dirk)

    2007-01-01

    htmlabstractRecent research into single-objective continuous Estimation-of-Distribution Algorithms (EDAs) has shown that when maximum-likelihood estimations are used for parametric distributions such as the normal distribution, the EDA can easily suffer from premature convergence. In this paper we

  13. ITER management advisory committee meeting

    International Nuclear Information System (INIS)

    Yoshikawa, M.

    2001-01-01

    The ITER Management Advisory Committee (MAC) Meeting was held in Vienna on 16 July 2001. It was the last MAC Meeting and the main topics were consideration of the report by the Director on the ITER EDA status, review of the Work Programme, review of the Joint Fund and arrangements for termination and wind-up of the EDA

  14. 13 CFR 307.16 - Effective utilization of Revolving Loan Funds.

    Science.gov (United States)

    2010-01-01

    ... the prescribed lending schedule, EDA may de-obligate the non-disbursed balance of the RLF Grant. EDA... control of the RLF Recipient; (ii) The financial need for the RLF still exists; (iii) The current and... loaned. (2) When the percentage of loaned RLF Capital falls below the applicable capital utilization...

  15. Consensus and variations in opinions on delirium care: a survey of European delirium specialists

    NARCIS (Netherlands)

    Morandi, A.; Davis, D.; Taylor, J. K.; Bellelli, G.; Olofsson, B.; Kreisel, S.; Teodorczuk, A.; Kamholz, B.; Hasemann, W.; Young, J.; Agar, M.; de Rooij, S. E.; Meagher, D.; Trabucchi, M.; Maclullich, A. M.

    2013-01-01

    There are still substantial uncertainties over best practice in delirium care. The European Delirium Association (EDA) conducted a survey of its members and other interested parties on various aspects of delirium care. The invitation to participate in the online survey was distributed among the EDA

  16. Evaluation of a Biofeedback Intervention in College Students Diagnosed with Autism Spectrum Disorders

    Science.gov (United States)

    Westlake, Garret

    2013-01-01

    This study used exploratory data analysis (EDA) to examine the use of a biofeedback intervention in the treatment of anxiety for college students diagnosed with an Autism Spectrum Disorder (ASD) (n = 10) and in a typical college population (n = 37). The use of EDA allowed for trends to emerge from the data and provided a foundation for future…

  17. Density, viscosity, surface tension, and spectroscopic properties for binary system of 1,2-ethanediamine + diethylene glycol

    International Nuclear Information System (INIS)

    Li, Lihua; Zhang, Jianbin; Li, Qiang; Guo, Bo; Zhao, Tianxiang; Sha, Feng

    2014-01-01

    Graphical abstract: Excess property of the binary system 1,2-ethanediamine (EDA) + diethylene glycol (DEG). - Highlights: • Densities and viscosities of EDA + DEG at 298.15–318.150 K were listed. • Thermodynamics data of EDA + DEG at 298.15–318.15 K were calculated. • Surface tension of EDA + DEG at 298.15 K was measured. • Intermolecular interaction of EDA with DEG was discussed. - Abstract: This paper reports density and viscosity data at T = 298.15, 303.15, 308.15, 313.15, and 318.15 K and surface tension data at 298.15 K for the binary system 1,2-ethanediamine (EDA) + diethylene glycol (DEG) as a function of composition under atmospheric pressure. From the experimental density and viscosity data, the excess molar volume and viscosity deviation were calculated, and the results were fitted to a Redlich–Kister equation to obtain the coefficients and to estimate the standard deviations between the experimental and calculated quantities. Based on the kinematic viscosity data, enthalpy of activation for viscous flow, entropy of activation for the viscous flow, and Gibbs energies of activation of viscous flow were calculated. In addition, based on Fourier transform infrared spectra, UV–vis spectra, and electrical conductivity for the system EDA + DEG with various concentrations, intermolecular interaction of EDA with DEG was discussed

  18. Electrodermal Activity of Undersocialized Aggressive Children: A Pilot Study.

    Science.gov (United States)

    Schmidt, Katalin; And Others

    1985-01-01

    Investigated the electrodermal activity (EDA) of a small group of prepubertal children suffering from a severe form of undersocialized aggressive conduct disorder (CD). The EDA profile of the CD children resembled that of the adult sociopath on phasic measures only. (RH)

  19. A modified estimation distribution algorithm based on extreme elitism.

    Science.gov (United States)

    Gao, Shujun; de Silva, Clarence W

    2016-12-01

    An existing estimation distribution algorithm (EDA) with univariate marginal Gaussian model was improved by designing and incorporating an extreme elitism selection method. This selection method highlighted the effect of a few top best solutions in the evolution and advanced EDA to form a primary evolution direction and obtain a fast convergence rate. Simultaneously, this selection can also keep the population diversity to make EDA avoid premature convergence. Then the modified EDA was tested by means of benchmark low-dimensional and high-dimensional optimization problems to illustrate the gains in using this extreme elitism selection. Besides, no-free-lunch theorem was implemented in the analysis of the effect of this new selection on EDAs. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. Markov Networks in Evolutionary Computation

    CERN Document Server

    Shakya, Siddhartha

    2012-01-01

    Markov networks and other probabilistic graphical modes have recently received an upsurge in attention from Evolutionary computation community, particularly in the area of Estimation of distribution algorithms (EDAs).  EDAs have arisen as one of the most successful experiences in the application of machine learning methods in optimization, mainly due to their efficiency to solve complex real-world optimization problems and their suitability for theoretical analysis. This book focuses on the different steps involved in the conception, implementation and application of EDAs that use Markov networks, and undirected models in general. It can serve as a general introduction to EDAs but covers also an important current void in the study of these algorithms by explaining the specificities and benefits of modeling optimization problems by means of undirected probabilistic models. All major developments to date in the progressive introduction of Markov networks based EDAs are reviewed in the book. Hot current researc...

  1. Utilização de cenários de mudança para a previsão da evolução das pressões e do estado das massas de água subterrâneas e EDAS - Caso de estudo:Melides. Cenários de alterações climáticas

    OpenAIRE

    Novo, M. E.; Oliveira, L. G. S.

    2014-01-01

    Neste artigo faz-se uma projecção da avaliação da evolução das pressões sobre as águas superficiais e subterrâneas da bacia de Melides sob cenários de alterações climáticas para o horizonte temporal de 2100 e cenários de emissões IS92a, SRES A2 e SRES B2. Os valores de recarga e escoamento superficial para estes cenários e consequente variação do volume médio da lagoa de Melides foram depois cruzados com a evolução das pressões qualitativas e quantitativas. A evolução das press...

  2. Chemical hydrogels based on a hyaluronic acid-graft-α-elastin derivative as potential scaffolds for tissue engineering

    International Nuclear Information System (INIS)

    Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Fiorica, Calogero; Rigogliuso, Salvatrice; Ghersi, Giulio; Giammona, Gaetano

    2013-01-01

    In this work hyaluronic acid (HA) functionalized with ethylenediamine (EDA) has been employed to graft α-elastin. In particular a HA-EDA derivative bearing 50 mol% of pendant amino groups has been successfully employed to produce the copolymer HA-EDA-g-α-elastin containing 32% w/w of protein. After grafting with α-elastin, remaining free amino groups reacted with ethylene glycol diglycidyl ether (EGDGE) for producing chemical hydrogels, proposed as scaffolds for tissue engineering. Swelling degree, resistance to chemical and enzymatic hydrolysis, as well as preliminary biological properties of HA-EDA-g-α-elastin/EGDGE scaffold have been evaluated and compared with a HA-EDA/EGDGE scaffold. The presence of α-elastin grafted to HA-EDA improves attachment, viability and proliferation of primary rat dermal fibroblasts and human umbilical artery smooth muscle cells. Biological performance of HA-EDA-g-α-elastin/EGDGE scaffold resulted comparable to that of a commercial collagen type I sponge (Antema®), chosen as a positive control. - Highlights: ► Hyaluronic acid (HA) has been functionalized with ethylenediamine (EDA). ► Amino groups of HA-EDA allow the reaction with α-elastin and ethylene glycol diglycidyl ether (EGDGE). ► Chemical scaffolds of HA-EDA-graft-α-elastin/EGDGE have been characterized. ► The presence of α-elastin affects porosity, swelling and enzymatic degradation of scaffolds. ► The presence of α-elastin improves attachment, viability and proliferation of fibroblasts and smooth muscle cells

  3. Chemical hydrogels based on a hyaluronic acid-graft-α-elastin derivative as potential scaffolds for tissue engineering

    Energy Technology Data Exchange (ETDEWEB)

    Palumbo, Fabio Salvatore [Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo (Italy); Pitarresi, Giovanna, E-mail: giovanna.pitarresi@unipa.it [Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo (Italy); Institute of Biophysics at Palermo, Italian National Research Council, Via Ugo La Malfa 153, 90146 Palermo (Italy); Fiorica, Calogero [Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo (Italy); Rigogliuso, Salvatrice; Ghersi, Giulio [Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Biologia Cellulare, Università degli Studi di Palermo, Viale delle Scienze ed. 16, 90128, Palermo (Italy); Giammona, Gaetano [Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo (Italy); IBIM-CNR, Via Ugo La Malfa 153, 90146 Palermo (Italy)

    2013-07-01

    In this work hyaluronic acid (HA) functionalized with ethylenediamine (EDA) has been employed to graft α-elastin. In particular a HA-EDA derivative bearing 50 mol% of pendant amino groups has been successfully employed to produce the copolymer HA-EDA-g-α-elastin containing 32% w/w of protein. After grafting with α-elastin, remaining free amino groups reacted with ethylene glycol diglycidyl ether (EGDGE) for producing chemical hydrogels, proposed as scaffolds for tissue engineering. Swelling degree, resistance to chemical and enzymatic hydrolysis, as well as preliminary biological properties of HA-EDA-g-α-elastin/EGDGE scaffold have been evaluated and compared with a HA-EDA/EGDGE scaffold. The presence of α-elastin grafted to HA-EDA improves attachment, viability and proliferation of primary rat dermal fibroblasts and human umbilical artery smooth muscle cells. Biological performance of HA-EDA-g-α-elastin/EGDGE scaffold resulted comparable to that of a commercial collagen type I sponge (Antema®), chosen as a positive control. - Highlights: ► Hyaluronic acid (HA) has been functionalized with ethylenediamine (EDA). ► Amino groups of HA-EDA allow the reaction with α-elastin and ethylene glycol diglycidyl ether (EGDGE). ► Chemical scaffolds of HA-EDA-graft-α-elastin/EGDGE have been characterized. ► The presence of α-elastin affects porosity, swelling and enzymatic degradation of scaffolds. ► The presence of α-elastin improves attachment, viability and proliferation of fibroblasts and smooth muscle cells.

  4. Effects of Flexible Dry Electrode Design on Electrodermal Activity Stimulus Response Detection.

    Science.gov (United States)

    Haddad, Peter A; Servati, Amir; Soltanian, Saeid; Ko, Frank; Servati, Peyman

    2017-12-01

    The focus of this research is to evaluate the effects of design parameters including surface area, distance between and geometry of dry flexible electrodes on electrodermal activity (EDA) stimulus response detection. EDA is a result of the autonomic nervous system being stimulated, which causes sweat and changes the electrical characteristics of the skin. Standard silver/silver chloride (Ag/AgCl) EDA electrodes are rigid and lack conformability in contact with skin. In this study, flexible dry Ag/AgCl EDA electrodes were fabricated on a compliant substrate, used to monitor EDA stimulus responses and compared to results simultaneously collected by rigid dry Ag/AgCl electrodes. A repeatable fabrication process for flexible Ag/AgCl electrodes has been established. Surface area, distance between and geometry of electrodes are shown to affect the detectability of the EDA response and the minimum number of sweat glands to be covered by the electrodes has been estimated at 140, or more, in order to maintain functionality. The optimal flexible EDA electrode is a serpentine design with a 0.15 cm 2 surface area and a 0.20 cm distance with an average Pearson correlation coefficient of . Fabrication of flexible electrodes is described and an understanding of the effects of electrode designs on the EDA stimulus response detection has been established and is potentially related to the coverage of sweat glands. This work presents a novel systematic approach to understand the effects of electrode designs on monitoring EDA which is of importance for the design of wearable EDA monitoring devices.

  5. Epidural Analgesia Versus Patient-Controlled Analgesia for Pain Relief in Uterine Artery Embolization for Uterine Fibroids: A Decision Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kooij, Sanne M. van der, E-mail: s.m.vanderkooij@amc.uva.nl; Moolenaar, Lobke M.; Ankum, Willem M. [Academic Medical Centre, Department of Gynaecology (Netherlands); Reekers, Jim A. [Academic Medical Centre, Department of Radiology (Netherlands); Mol, Ben Willem J. [Academic Medical Centre, Department of Gynaecology (Netherlands); Hehenkamp, Wouter J. K. [VU University Medical Centre, Department of Gynaecology (Netherlands)

    2013-12-15

    Purpose: This study was designed to compare the costs and effects of epidural analgesia (EDA) to those of patient-controlled intravenous analgesia (PCA) for postintervention pain relief in women having uterine artery embolization (UAE) for systematic uterine fibroids. Methods: Cost-effectiveness analysis (CEA) based on data from the literature by constructing a decision tree to model the clinical pathways for estimating the effects and costs of treatment with EDA and PCA. Literature on EDA for pain-relief after UAE was missing, and therefore, data on EDA for abdominal surgery were used. Outcome measures were compared costs to reduce one point in visual analogue score (VAS) or numeric rating scale (NRS) for pain 6 and 24 h after UAE and risk for complications. Results: Six hours after the intervention, the VAS was 3.56 when using PCA and 2.0 when using EDA. The costs for pain relief in women undergoing UAE with PCA and EDA were Euro-Sign 191 and Euro-Sign 355, respectively. The costs for EDA to reduce the VAS score 6 h after the intervention with one point compared with PCA were Euro-Sign 105 and Euro-Sign 179 after 24 h. The risk of having a complication was 2.45 times higher when using EDA. Conclusions: The results of this indirect comparison of EDA for abdominal surgery with PCA for UAE show that EDA would provide superior analgesia for post UAE pain at 6 and 24 h but with higher costs and an increased risk of complications.

  6. Use of electronic dietary assessment tools in primary care: an interdisciplinary perspective.

    Science.gov (United States)

    Bonilla, Carolina; Brauer, Paula; Royall, Dawna; Keller, Heather; Hanning, Rhona M; DiCenso, Alba

    2015-02-25

    Dietary assessment can be challenging for many reasons, including the wide variety of foods, eating patterns and nutrients to be considered. In team-based primary care practice, various disciplines may be involved in assessing diet. Electronic-based dietary assessment (e-DA) instruments available now through mobile apps or websites can potentially facilitate dietary assessment. Providers views of facilitators and barriers related to e-DA instruments and their recommendations for improvement can inform the further development of these tools. The objective of this study was to explore provider perspectives on e-DA tools in mobile apps and websites. The exploratory sequential mixed methods design included interdisciplinary focus groups followed by a web-based survey sent to Family Health Teams throughout Ontario, Canada. Descriptive and bivariate analyses were completed. Focus group transcripts contributed to web-survey content, while interpretive themes added depth and context. 11 focus groups with 50 providers revealed varying perspectives on the use of e-DA for: 1) improving patients' eating habits; 2) improving the quality of dietary assessment; and, 3) integrating e-DA into the care process. In the web-survey 191 respondents from nine disciplines in 73 FHTs completed the survey. Dietitians reported greater use of e-DA than other providers (63% vs.19%; p = .000) respectively. There was strong interest among disciplines in the use of e-DA tools for the management of obesity, diabetes and heart disease, especially for patient self-monitoring. Barriers identified were: patients' lack of comfort with using technology, misinterpretation of e-DA results by patients, time and education for providers to interpret results, and time for providers to offer counselling. e-DA tools in mobile apps and websites may improve dietary counselling over time. Addressing the identified facilitators and barriers can potentially promote the uptake of e-DA into clinical practice.

  7. Chemical hydrogels based on a hyaluronic acid-graft-α-elastin derivative as potential scaffolds for tissue engineering.

    Science.gov (United States)

    Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Fiorica, Calogero; Rigogliuso, Salvatrice; Ghersi, Giulio; Giammona, Gaetano

    2013-07-01

    In this work hyaluronic acid (HA) functionalized with ethylenediamine (EDA) has been employed to graft α-elastin. In particular a HA-EDA derivative bearing 50 mol% of pendant amino groups has been successfully employed to produce the copolymer HA-EDA-g-α-elastin containing 32% w/w of protein. After grafting with α-elastin, remaining free amino groups reacted with ethylene glycol diglycidyl ether (EGDGE) for producing chemical hydrogels, proposed as scaffolds for tissue engineering. Swelling degree, resistance to chemical and enzymatic hydrolysis, as well as preliminary biological properties of HA-EDA-g-α-elastin/EGDGE scaffold have been evaluated and compared with a HA-EDA/EGDGE scaffold. The presence of α-elastin grafted to HA-EDA improves attachment, viability and proliferation of primary rat dermal fibroblasts and human umbilical artery smooth muscle cells. Biological performance of HA-EDA-g-α-elastin/EGDGE scaffold resulted comparable to that of a commercial collagen type I sponge (Antema®), chosen as a positive control. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway

    International Nuclear Information System (INIS)

    White, Eric S.; Sagana, Rommel L.; Booth, Adam J.; Yan, Mei; Cornett, Ashley M.; Bloomheart, Christopher A.; Tsui, Jessica L.; Wilke, Carol A.; Moore, Bethany B.; Ritzenthaler, Jeffrey D.; Roman, Jesse; Muro, Andres F.

    2010-01-01

    Fibronectin (FN), a ubiquitous glycoprotein that plays critical roles in physiologic and pathologic conditions, undergoes alternative splicing which distinguishes plasma FN (pFN) from cellular FN (cFN). Although both pFN and cFN can be incorporated into the extracellular matrix, a distinguishing feature of cFN is the inclusion of an alternatively spliced exon termed EDA (for extra type III domain A). The molecular steps involved in EDA splicing are well-characterized, but pathways influencing EDA splicing are less clear. We have previously found an obligate role for inhibition of the tumor suppressor phosphatase and tensin homologue on chromosome 10 (PTEN), the primary regulator of the PI3K/Akt pathway, in fibroblast activation. Here we show TGF-β, a potent inducer of both EDA splicing and fibroblast activation, inhibits PTEN expression and activity in mesenchymal cells, corresponding with enhanced PI3K/Akt signaling. In pten -/- fibroblasts, which resemble activated fibroblasts, inhibition of Akt attenuated FN production and decreased EDA alternative splicing. Moreover, inhibition of mammalian target of rapamycin (mTOR) in pten -/- cells also blocked FN production and EDA splicing. This effect was due to inhibition of Akt-mediated phosphorylation of the primary EDA splicing regulatory protein SF2/ASF. Importantly, FN silencing in pten -/- cells resulted in attenuated proliferation and migration. Thus, our results demonstrate that the PI3K/Akt/mTOR axis is instrumental in FN transcription and alternative splicing, which regulates cell behavior.

  9. The investigation of the interaction between edaravone and bovine serum albumin by spectroscopic approaches

    International Nuclear Information System (INIS)

    Yu Xianyong; Yang Ying; Liu Ronghua; Huang Haowen; Chen Jian; Ji Danhong; Li Xiaofang; Yang Fengxian; Yi Pinggui

    2011-01-01

    The fluorescence and ultraviolet spectroscopies were explored to study the interaction between edaravone (EDA) and bovine serum albumin (BSA) under imitated physiological condition. The experimental results show that the fluorescence quenching mechanism between EDA and BSA is a combined quenching (dynamic and static quenching). The binding constants, binding sites, and the corresponding thermodynamic parameters (ΔG, ΔH, and ΔS) of the interaction system were calculated at different temperatures. According to Foerster non-radiation energy transfer theory, the binding distance between EDA and BSA was calculated to be 3.10 nm. The effect of EDA on the conformation of BSA was analyzed using synchronous fluorescence spectroscopy. In addition, the effects of some common metal ions Mg 2+ , Ca 2+ , Cu 2+ , and Ni 2+ on the binding constant between EDA and BSA were examined. - Highlights: → We explored the interaction of BSA and EDA using spectroscopic methods. → The fluorescence quenching mechanism is combined quenching. → Hydrophobic interaction force plays a major role in stabilizing the complex. → The binding constants, binding sites, and thermodynamic parameters were calculated. → EDA affects the conformation of tryptophan residue's microregion.

  10. Edaravone, a free radical scavenger, protects liver against valproic acid induced toxicity

    Directory of Open Access Journals (Sweden)

    Cakmak Neziha Hacihasanoglu

    2015-01-01

    Full Text Available Valproic acid (VPA, is a well established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy. Edaravone (EDA; 3-methyl-1-phenyl-2-pyrazoline-5-one is a potent free radical scavenger. In this study, we aimed to investigate the effects of EDA on VPA-induced hepatic damage. Male Sprague Dawley rats were divided into four groups. Group I was control animals. Group II was control rats given valproic acid (500 mg kg-1 day for seven days. Group III was given only EDA (30 mg kg-1day for seven days. Group IV was given VPA+EDA (in same dose and time. EDA and VPA were given intraperitoneally. On the 8th day of experiment, blood samples and liver tissue were taken. Serum aspartate and alanine aminotransferase, alkaline phosphatase and bilirubin levels, liver myeloperoxidase, xanthine oxidase, adenosine deaminase, Na+/K+ATPase, sorbitol dehydrogenase, glutamate dehydrogenase, DT-diaphorase, arginase and thromboplastic activities, lipid peroxidation, protein carbonyl levels were increased whereas paraoxonase, biotinidase activities and glutathione levels were decreased in VPA group. Application of EDA with VPA protected against VPA-induced effects. These results demonstrated that administration of EDA is a potentially beneficial agent to reduce hepatic damage in VPA induced hepatotoxicity, probably by decreasing oxidative stress.

  11. Inhibitory Effects of Edaravone in β-Amyloid-Induced Neurotoxicity in Rats

    Directory of Open Access Journals (Sweden)

    Feng He

    2014-01-01

    Full Text Available Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis. Edaravone, a potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect in stroke patients. The current study aimed to investigate the effects of EDA in an Aβ-induced rat model of AD, by studying Aβ1–40-induced voltage-gated calcium channel currents in hippocampal CA1 pyramidal neurons, learning and memory behavioral tests, the number of surviving cholinergic neurons in the basal forebrain, and the acetylcholine level in the hippocampus in this rat model of AD. The results showed that the Aβ1–40-induced increase of ICa can be inhibited by EDA in a dose-dependent manner. Treatment with EDA significantly improved Aβ1–40-induced learning and memory performance. Choline acetyltransferase positive cells in basal forebrain and acetylcholine content in the hippocampus were increased by the administration of EDA as compared with the non-EDA treated Aβ1–40 group. These results demonstrate that EDA can inhibit the neurotoxic effect of Aβ toxicity. Collectively, these findings suggest that EDA may serve as a potential complemental treatment strategy for AD.

  12. The investigation of the interaction between edaravone and bovine serum albumin by spectroscopic approaches

    Energy Technology Data Exchange (ETDEWEB)

    Xianyong, Yu; Ying, Yang; Ronghua, Liu; Haowen, Huang; Jian, Chen; Danhong, Ji [Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201 (China); Li Xiaofang, E-mail: fine_chem@163.co [Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201 (China); Fengxian, Yang [Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201 (China); Yi Pinggui, E-mail: pgyi@hnust.c [Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201 (China)

    2011-07-15

    The fluorescence and ultraviolet spectroscopies were explored to study the interaction between edaravone (EDA) and bovine serum albumin (BSA) under imitated physiological condition. The experimental results show that the fluorescence quenching mechanism between EDA and BSA is a combined quenching (dynamic and static quenching). The binding constants, binding sites, and the corresponding thermodynamic parameters ({Delta}G, {Delta}H, and {Delta}S) of the interaction system were calculated at different temperatures. According to Foerster non-radiation energy transfer theory, the binding distance between EDA and BSA was calculated to be 3.10 nm. The effect of EDA on the conformation of BSA was analyzed using synchronous fluorescence spectroscopy. In addition, the effects of some common metal ions Mg{sup 2+}, Ca{sup 2+}, Cu{sup 2+}, and Ni{sup 2+} on the binding constant between EDA and BSA were examined. - Highlights: {yields} We explored the interaction of BSA and EDA using spectroscopic methods. {yields} The fluorescence quenching mechanism is combined quenching. {yields} Hydrophobic interaction force plays a major role in stabilizing the complex. {yields} The binding constants, binding sites, and thermodynamic parameters were calculated. {yields} EDA affects the conformation of tryptophan residue's microregion.

  13. Electrodermal complexity during the Stroop colour word test.

    Science.gov (United States)

    Svetlak, Miroslav; Bob, Petr; Cernik, Michal; Kukleta, Miloslav

    2010-01-15

    Several recent studies suggest that quantitative description of signal complexity using algorithms of nonlinear analysis could uncover new information about the autonomic system that is not reflected using common methods applied to measures of autonomic activity. With this aim we have performed complexity analysis of electrodermal activity (EDA) assessed in 106 healthy university students during rest conditions and non-conflicting and conflicting Stroop task. Complexity analysis applied to EDA was performed using Skinner's algorithm for pointwise correlation dimension (PD2). Results have shown that EDA responses during the Stroop Colour Word test are related to significantly increased or decreased complexity. Particularly significant result is that PD2 has a unique ability to predict to an extent the change in EDA response to stress i.e. that subjects with low initial PD2 tended to respond to experimental stress by its increase and subjects with high initial PD2 values tended to respond by its decrease. This response was not found in EDA measures where increase of the EDA presented predominant response to experimental stress in majority of the subjects. These findings suggest that PD2 is more sensitive to subtle aspects of functionally and spatially distributed modulatory influences of various parts of the brain that are involved in the EDA modulation and provides novel information in comparison to traditional methods.

  14. Artifact detection in electrodermal activity using sparse recovery

    Science.gov (United States)

    Kelsey, Malia; Palumbo, Richard Vincent; Urbaneja, Alberto; Akcakaya, Murat; Huang, Jeannie; Kleckner, Ian R.; Barrett, Lisa Feldman; Quigley, Karen S.; Sejdic, Ervin; Goodwin, Matthew S.

    2017-05-01

    Electrodermal Activity (EDA) - a peripheral index of sympathetic nervous system activity - is a primary measure used in psychophysiology. EDA is widely accepted as an indicator of physiological arousal, and it has been shown to reveal when psychologically novel events occur. Traditionally, EDA data is collected in controlled laboratory experiments. However, recent developments in wireless biosensing have led to an increase in out-of-lab studies. This transition to ambulatory data collection has introduced challenges. In particular, artifacts such as wearer motion, changes in temperature, and electrical interference can be misidentified as true EDA responses. The inability to distinguish artifact from signal hinders analyses of ambulatory EDA data. Though manual procedures for identifying and removing EDA artifacts exist, they are time consuming - which is problematic for the types of longitudinal data sets represented in modern ambulatory studies. This manuscript presents a novel technique to automatically identify and remove artifacts in EDA data using curve fitting and sparse recovery methods. Our method was evaluated using labeled data to determine the accuracy of artifact identification. Procedures, results, conclusions, and future directions are presented.

  15. β-Zeolite modified by ethylenediamine for sorption of Th(IV)

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Peng; Wu, Hanyu; Yuan, Ni; Yin, Zhuoxin; Pan, Duoqiang; Wu, Wangsuo [Lanzhou Univ. (China). Radiochemistry Lab.; Ministry of Education, Lanzhou (China). Key Lab. of Special Function Materials and Structure Design

    2017-08-01

    β-Zeolite-EDA was modified with ethylenediamine (EDA) after synthesized. The synthesized material was characterized and used for removal of Th(IV) from aqueous solutions. The influences of pH, ionic strength, contact time, temperature and humic acid (HA) on Th(IV) sorption onto synthesized β-zeolite-EDA was studied by batch technique. The dynamic process showed that the sorption of Th(IV) onto β-zeolite-EDA matched the pseudo-second-order kinetics model. The sorption of Th(IV) on β-zeolite-EDA was significantly dependent on pH values, the sorption percentage increased markedly at pH 3.5-4.5, and then maintained a steady state as pH values increased. Through simulating the sorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich (D-R) models, it could be seen respectively that the sorption pattern of Th(IV) on β-zeolite-EDA was mainly controlled by surface complexation, and that the sorption processes was endothermic and spontaneous. The presence of HA increased Th(IV) sorption on β-zeolite-EDA.

  16. Autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency caused by a novel NFKBIA mutation, p.Ser36Tyr, presents with mild ectodermal dysplasia and non-infectious systemic inflammation.

    Science.gov (United States)

    Yoshioka, Takakazu; Nishikomori, Ryuta; Hara, Junichi; Okada, Keiko; Hashii, Yoshiko; Okafuji, Ikuo; Nodomi, Seishiro; Kawai, Tomoki; Izawa, Kazushi; Ohnishi, Hidenori; Yasumi, Takahiro; Nakahata, Tatsutoshi; Heike, Toshio

    2013-10-01

    Anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) is characterized by hypohidrosis, dental abnormalities, sparse hair, and immunodeficiency. Autosomal dominant (AD)-EDA-ID, caused by a heterozygous mutation within NFKBIA, is very rare and its clinical features remain largely unknown. This study describes a patient with AD-EDA-ID harboring a novel NFKBIA mutation who presented with mild EDA and non-infectious systemic inflammation. The clinical presentation of an AD-EDA-ID patient was described and immunological, genetic, and biochemical analyses were performed, with a focus on nuclear factor kappa B (NF-κB) activation. The patient presented with symptoms of mild EDA-ID, namely sparse hair and hypohidrosis, although a skin biopsy confirmed the presence of sweat glands. There were no dental abnormalities. The patient also suffered from non-infectious inflammation, which responded to systemic corticosteroid therapy; however, the patient remained ill. Immunological analyses revealed reduced Toll-like receptor/IL-1 (TLR/IL-1) and tumor necrosis factor (TNF) receptor family responses to various stimuli. Genetic analysis identified a de novo heterozygous missense mutation, p.Ser36Tyr, in NFKBIA, resulting in defective NFKBIA degradation and impaired NF-κB activation. The patient was diagnosed with AD-EDA-ID and underwent hematopoietic stem cell transplantation. Engraftment was successful, with few signs of acute graft versus host disease. However, the patient suffered hemolytic anemia and thrombocytopenia, and died from a brain hemorrhage due to intractable thrombocytopenia. AD-EDA-ID patients can present with mild ectodermal dysplasia and non-infectious inflammation, rather than with recurrent infections. Also, hematopoietic stem cell transplantation for AD-EDA-ID is still a clinical challenge.

  17. Missed losses loom larger than missed gains: Electrodermal reactivity to decision choices and outcomes in a gambling task.

    Science.gov (United States)

    Wu, Yin; Van Dijk, Eric; Aitken, Mike; Clark, Luke

    2016-04-01

    Loss aversion is a defining characteristic of prospect theory, whereby responses are stronger to losses than to equivalently sized gains (Kahneman & Tversky Econometrica, 47, 263-291, 1979). By monitoring electrodermal activity (EDA) during a gambling task, in this study we examined physiological activity during risky decisions, as well as to both obtained (e.g., gains and losses) and counterfactual (e.g., narrowly missed gains and losses) outcomes. During the bet selection phase, EDA increased linearly with bet size, highlighting the role of somatic signals in decision-making under uncertainty in a task without any learning requirement. Outcome-related EDA scaled with the magnitudes of monetary wins and losses, and losses had a stronger impact on EDA than did equivalently sized wins. Narrowly missed wins (i.e., near-wins) and narrowly missed losses (i.e., near-losses) also evoked EDA responses, and the change of EDA as a function of the size of the missed outcome was modestly greater for near-losses than for near-wins, suggesting that near-losses have more impact on subjective value than do near-wins. Across individuals, the slope for choice-related EDA (as a function of bet size) correlated with the slope for outcome-related EDA as a function of both the obtained and counterfactual outcome magnitudes, and these correlations were stronger for loss and near-loss conditions than for win and near-win conditions. Taken together, these asymmetrical EDA patterns to objective wins and losses, as well as to near-wins and near-losses, provide a psychophysiological instantiation of the value function curve in prospect theory, which is steeper in the negative than in the positive domain.

  18. Guía para la práctica clínica de las enfermedades diarreicas agudas

    OpenAIRE

    Freijoso Santiesteban, Elsie; Cires Pujol, María Miriam; Silva Herrera, Lázaro; Delgado Martínez, Ibis; Riverón Corteguera, Raúl; Ramírez, Margarita

    2003-01-01

    Se presenta una guía para la práctica clínica de las enfermedades diarreicas agudas (EDA), cuyo objetivo principal es el de establecer recomendaciones para el manejo terapéutico de pacientes con EDA. En la misma se abordan las definiciones y causas de las EDA, los objetivos del tratamiento, la evaluación del paciente con diarreas y las características clínico epidemiológicas, así como las consideraciones terapéuticas y tratamientos para las diarreas causadas por diferentes microorganismos.A c...

  19. Recovery of Uranium from Seawater: Modified Polyacrylonitrile Fibers as Selective Extractants

    Energy Technology Data Exchange (ETDEWEB)

    Alexandratos, Spiro D. [City Univ. (CUNY), NY (United States)

    2017-03-15

    A new bifunctional fiber has been prepared and found to have a significant loading capacity of uranium from real seawater. The fiber support is polyacrylonitrile and bifunctionality is provided by amidoxime and either diethylenetriamine (DETA) or ethylenediamine (EDA) ligands. The key feature is adjusting the hydrophilic /lipophilic balance within the fiber and this was best accomplished by partially acetylating or carboxylating EDA ligands. The bifunctional carboxylated EDA /AO fiber had a loading capacity of 3.83 mg U/g fiber at the Pacific Northwest National Laboratory with a 21 day contact time in real seawater.

  20. The use of easily debondable orthodontic adhesives with ceramic brackets.

    Science.gov (United States)

    Ryu, Chiyako; Namura, Yasuhiro; Tsuruoka, Takashi; Hama, Tomohiko; Kaji, Kaori; Shimizu, Noriyoshi

    2011-01-01

    We experimentally produced an easily debondable orthodontic adhesive (EDA) containing heat-expandable microcapsules. The purpose of this in vitro study was to evaluate the best debondable condition when EDA was used for ceramic brackets. Shear bond strengths were measured before and after heating and were compared statistically. Temperatures of the bracket base and pulp wall were also examined during heating. Bond strengths of EDA containing 30 wt% and 40 wt% heat-expandable microcapsules were 13.4 and 12.9 MPa, respectively and decreased significantly to 3.8 and 3.7 MPa, respectively, after heating. The temperature of the pulp wall increased 1.8-3.6°C after heating, less than that required to induce pulp damage. Based on the results, we conclude that heating for 8 s during debonding of ceramic brackets bonded using EDA containing 40 wt% heat-expandable microcapsules is the most effective and safest method for the enamel and pulp.

  1. ITER management advisory committee meeting in NAKA

    International Nuclear Information System (INIS)

    Yoshikawa, M.

    1999-01-01

    The ITER Management Advisory Committee (MAC) Meeting was held on 17 December 1999 in Naka, Japan. The main topics were the ITER EDA Status, Task Status Summary and Work Program and a schedule of ITER meetings

  2. Hillitsetud feministid / Teet Veispak

    Index Scriptorium Estoniae

    Veispak, Teet, 1955-

    2000-01-01

    Ajakirja "Ariadne Lõng" esinumbrist, mis esindab liberaalse feminismi vaateid. Katrin Kivimaa artiklist "Teise tootmine - Ida-Euroopa ja feminism". Esile on tõstetud kunstiteadlaste Reet Varblase ja Eda Sepa artiklid.

  3. General Controls Over the Electronic Document Access System

    National Research Council Canada - National Science Library

    2000-01-01

    ...) system as part of the DoD Paper-Free Contracting Initiative. EDA contributes to the initiative by digitizing paper documents and offering web-based read-only access to official contracting, finance and accounting documents...

  4. 77 FR 6517 - Economic Development Administration Regulatory Revision; Comment Period Extension

    Science.gov (United States)

    2012-02-08

    ... DEPARTMENT OF COMMERCE Economic Development Administration 13 CFR Parts 300, 301, 302, 303, 304... Development Administration Regulatory Revision; Comment Period Extension AGENCY: Economic Development.... SUMMARY: On December 7, 2011, the Department of Commerce's Economic Development Administration (EDA...

  5. Fourteenth meeting of the ITER management advisory committee

    International Nuclear Information System (INIS)

    Yoshikawa, M.

    1998-01-01

    Following the Director's report on the progress made in the ITER Engineering Design Activities, the ITER Management Advisory Committee reviewed the Task Status Summary, Work Program and Task Agreements for EDA Extension, Joint Fund and a schedule of ITER meetings

  6. 77 FR 20355 - Proposed Information Collection; Comment Request; Award Amendment Requests and Project Service Maps

    Science.gov (United States)

    2012-04-04

    ... collection). Affected Public: Current recipients of EDA assistance, to include (1) cities or other political... DEPARTMENT OF COMMERCE Economic Development Administration Proposed Information Collection; Comment Request; Award Amendment Requests and Project Service Maps AGENCY: Economic Development...

  7. 77 FR 20007 - Proposed Information Collection; Comment Request; Property Management

    Science.gov (United States)

    2012-04-03

    ... record. Dated: March 29, 2012. Gwellnar Banks, Management Analyst, Office of the Chief Information... DEPARTMENT OF COMMERCE Economic Development Administration Proposed Information Collection; Comment Request; Property Management AGENCY: Economic Development Administration (EDA). ACTION: Notice...

  8. A long-term echocardiographic study of the course of valvular dysfunctions following discontinuation of ergot-derived dopamine agonists in patients with Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Walter Serra

    2015-03-01

    Conclusions: This long-term study confirms an improvement of the restrictive VHD after withdrawal of EDA in PD patients. However, only a partial reversibility of cardiac valvular abnormalities was observed.

  9. Prokurör nägi inimliku jõhkruse piiritust / Hinge Brand ; interv. Tiiu Põld

    Index Scriptorium Estoniae

    Brand, Hinge, 1940-2007

    2006-01-01

    Intervjuu ametist lahkuva prokurör Hinge Brandiga. Lisatud: Hinge Brandi CV; Hinge Brandi osavõtul peetud kõmulisemad mõrvaprotsessid. Kommenteerivad Aivar Pilv, Elmar Vaher, Alar Kirs, Eda Murak, Dilaila Nahkur-Tammiksaar

  10. Water Complexes of Cytochrome P450: Insights from Energy Decomposition Analysis

    Directory of Open Access Journals (Sweden)

    Hajime Hirao

    2013-06-01

    Full Text Available Water is a small molecule that nevertheless perturbs, sometimes significantly, the electronic properties of an enzyme’s active site. In this study, interactions of a water molecule with the ferric heme and the compound I (Cpd I intermediate of cytochrome P450 are studied. Energy decomposition analysis (EDA schemes are used to investigate the physical origins of these interactions. Localized molecular orbital EDA (LMOEDA implemented in the quantum chemistry software GAMESS and the EDA method implemented in the ADF quantum chemistry program are used. EDA reveals that the electrostatic and polarization effects act as the major driving force in both of these interactions. The hydrogen bonding in the Cpd I•••H2O complex is similar to that in the water dimer; however, the relative importance of the electrostatic effect is somewhat larger in the water dimer.

  11. Neli jaapani mängufilmi / Lauri Kitsnik

    Index Scriptorium Estoniae

    Kitsnik, Lauri

    2008-01-01

    Jaapani filmidest: "Elagu filmitegija!" ("Kantoku banzai") rezh. Takeshi Kitano (2007); "Sukiyaki Western Django" rezh. Takashi Miike (2007); "Hana" ("Hana yori mo nao)" rezh. Kore-eda Hirokazu (2006); "Leinav mets" ("Mogari no mori") rezh. Kawase Naomi (2007)

  12. Effects of electrical discharge surface modification of superalloy Haynes 230 with aluminum and molybdenum on oxidation behavior

    International Nuclear Information System (INIS)

    Bai, C.-Y.

    2007-01-01

    The effects of the electrical discharge alloying (EDA) process on improving the high temperature oxidation resistance of the Ni-based superalloy Haynes 230 have been investigated. The 85 at.% Al and 15 at.% Mo composite electrode provided the surface alloying materials. An Al-rich layer is produced on the surface of the EDA specimen alloyed with positive electrode polarity, whereas, many discontinuous piled layers are attached to the surface of the EDA superalloy when negative electrode polarity is selected. The oxidation resistance of the specimen alloyed with positive electrode polarity is better than that of the unalloyed superalloy, and the effective temperature of oxidation resistance of the alloyed layer can be achieved to 1100 o C. Conversely, the oxidation resistance of the other EDA specimen alloyed with negative electrode polarity is even worse than that of the unalloyed superalloy

  13. Two-step modification of poly(D, L-lactic acid) by ethylenediamine-maleic anhydride

    International Nuclear Information System (INIS)

    Cao Chengbo; Zhu Fanglian; Yu Xueli; Wang Qin; Wang Chuandong; Li Baolu; Lv Ronghui; Li Musen

    2008-01-01

    Poly(lactic acid) (PLA) was modified by maleic anhydride (MAH), then the resultant MAH modified PLA (MPLA) was acylated with ethylenediamine (EDA), so EDA-MAH modified PLA (EMPLA) was prepared. The results of DSC, FT-IR and NMR testified that MAH and EAD were successfully introduced into the original polymer. The hydrophilicity of EMPLA was considerably increased compared with that of PLA. The degradation experiment showed that the introduction of EDA into the original polymer could neutralize the carboxyl end groups of the degradation products. The results of SEM and MTT of rat osteoblasts cultured in vitro showed that the cytocompatibility and cell adhesion of the modified materials were significantly increased compared with the original polymer, especially EMPLA; the number of cells were obviously increased and cells attached firmly to the material; these were ascribed to the EDA neutralizing the carboxyl end groups of the degradation products

  14. Kunstiõpetajad hakkavad loomelaagrit pidama / Helgi Pajo

    Index Scriptorium Estoniae

    Pajo, Helgi

    2001-01-01

    15.-18. augustini Toolsel toimuvas kunstiõpetajate laagris tehakse keraamika maapõletust Kille Kruuvi, maakunsti Anne Kokkovi, õlimaali Tuuli Juksi ja looduslikku skulptuuri Eda Errase juhendamisel

  15. 77 FR 20006 - Proposed Information Collection; Comment Request; Requirements for Approved Construction Investments

    Science.gov (United States)

    2012-04-03

    ... to John Cobb, Program Analyst, Office of Regional Affairs, Room 7009, Economic Development... Economic Development Administration (EDA) is to lead the Federal economic agenda by promoting innovation... DEPARTMENT OF COMMERCE Economic Development Administration Proposed Information Collection...

  16. 75 FR 10219 - Solicitation of Applications for the FY 2010 University Center Economic Development Program...

    Science.gov (United States)

    2010-03-05

    ...'s Austin and Denver Regional Offices AGENCY: Economic Development Administration (EDA), Department... to lead the federal economic development agenda by promoting innovation and competitiveness... goal of enhancing regional economic development by promoting a favorable business environment to...

  17. 75 FR 53667 - Space Coast Regional Innovation Cluster Competition

    Science.gov (United States)

    2010-09-01

    ... Coast Regional Innovation Cluster Competition AGENCY: Economic Development Administration (EDA... upcoming availability of funding for the Space Coast Regional Innovation Cluster (RIC) Competition under... economic development initiatives aligned with regional cluster and competitiveness analyses to sustain the...

  18. A different perspective on resonance fitting

    International Nuclear Information System (INIS)

    Larson, N.M.

    2003-01-01

    Several tables and diagrams on total cross sections with and without relativistic kinematics are given. The performance of EDA, RAC and SAMMY computer codes are compared. Error correction algorithms are discussed

  19. TGFβ1-mediated PI3K/Akt and p38 MAP kinase dependent alternative splicing of fibronectin extra domain A in human podocyte culture.

    Science.gov (United States)

    Madne, Tarunkumar Hemraj; Dockrell, Mark Edward Carl

    2018-04-30

    Alternative splicing is an important gene regulation process to distribute proteins in health and diseases. Extra Domain A+ Fibronectin (EDA+Fn) is an alternatively spliced form of fibronectin (Fn) protein, present in the extra cellular matrix (ECM) and a recognised marker of various pathologies. TGFβ1 has been shown to induce alternative splicing of EDA+Fn in many cell types. Podocytes are spectacular cell type and play a key role in filtration and synthesise ECM proteins in renal physiology and pathology. In our previous study we have demonstrated expression and alternative splicing of EDA+Fn in basal condition in human podocytes culture. TGFβ1 further induced the basal expression and alternative splicing of EDA+Fn through Alk5 receptor and SR proteins. In this study, we have investigated TGFβ1 mediated signalling involved in alternative splicing of EDA+Fn in human podocytes. We have performed western blotting to characterise the expression of the EDA+Fn protein and other signalling proteins and RT-PCR to look for signalling pathways involved in regulation of alternative splicing of EDA+Fn in conditionally immortalised human podocytes culture.We have used TGFβ1 as a stimulator and SB431542, SB202190 and LY294002 for inhibitory studies. In this work, we have demonstrated in human podocytes culture TGFβ1 2.5ng/ml induced phosphorylation of Smad1/5/8, Smad2 and Smad3 via the ALK5 receptor. TGFβ1 significantly induced the PI3K/Akt pathway and the PI3K/Akt pathway inhibitor LY294002 significantly downregulated basal as well as TGFβ1 induced alternative splicing of EDA+Fn in human podocytes. In addition to this, TGFβ1 significantly induced the p38 MAP kinase signalling pathway and p38 MAP kinase signalling pathway inhibitor SB202190 downregulated the TGFβ1-mediated alternative splicing of EDA+Fn in human podocytes. The results with PI3K and p38 MAP kinase signalling pathway suggest that inhibiting PI3K signalling pathway downregulated the basal alternative

  20. International Assessment of Unmanned Ground Vehicles

    Science.gov (United States)

    2008-02-01

    and its funding has since been approved in 4-year blocks. 16 EDA Web Page. Background. Available: http://www.eda.europa.eu/genericitem.aspx?area...Establishment for Applied Science)], Belgium (Royal Military Acad- emy), Italy (Oto Melara of Finmeccanica), and Spain (Sener Ingenieria y Sistemas SA...ability as an international standard. 30 NATO RTO Web Site: http://www.rta.nato.int/ (Accessed January

  1. VALORACIÓN DE ENERGÍA DIGESTIBLE DE LA GLICERINA CRUDA PROVENIENTE DE ACEITE DE PALMA – Elaeis guineensi – PARA CERDOS EN CRECIMIENTO EN FUNCIÓN DEL NIVEL DE ALMIDÓN DE MAÍZ EN LA DIETA

    Directory of Open Access Journals (Sweden)

    C. A. Ordóñez-Gómez

    2017-01-01

    Full Text Available Para determinar la energía digestible aparente (EDA de la glicerina cruda (GC proveniente del aceite de palma ( Elaeis guineensis en cerdos se realizaron dos experimentos (E. En E1 se determinó la EDA para GC con la técnica de la bolsa móvil de nailon (TBMN utilizando ocho cerdos castrados con cánula duodenal. En E2 se determinaron la EDA y la energía metabolizable aparente (EMA para GC, por el método convencional con indicador (MCI, con 10 cerdos castrados ubicados en jaulas metabólicas. En E1 y E2 se evaluaron, en un arreglo factorial 2 x 5, dos niveles de almidón de maíz (NA en la dieta, 10% (NA10 y 12% (NA12, y cinco niveles de sustitución con GC (0%, 2 , 5%, 5,0%, 7 , 5% y 10% en E1 en un diseño completo al azar y en E2 en un diseño de cuadrado latino. Para TBMN y MCI los datos se analizaron mediante regresión lineal múltiple y el metabolismo del nitrógeno en MCI como un diseño de cuadrado latino utilizando los módulos REG y GLM del paquete SAS. Por TBMN no hubo efectos (P > 0 , 05 del NA sobre la EDA de GC. La EDA de GC se calculó en 3.251 kcal/kg MS. La EDA de GC en MCI dependió de NA (P 0 , 05. Los resultados de EDA corregidos por NA con MCI mostraron correlación alta (R 2 = 0 , 82 con TBMN. Con MCI se pudo establecer que el aumento en NA en la dieta reduce la EDA de GC.

  2. The Biodegradation of TNT in Enhanced Soil and Compost Systems

    Science.gov (United States)

    1978-01-01

    dimethylsulfoxide ( DMSO ) Is substituted for EDA because EDA tends to clog the sprayei . Dr. Chandler’s solvent system No. 1 is used for non-polar separa...material was converted to non- solvent -extractable, water-soluble materials of unknown Identity. These materials may represent the contents of dead... solvent system No. 1 54 2A TLC separation of TNT and derivatives using ChandlerIs solvent system No. 2 55 3A TLC separation of TNT and derivatives using

  3. Swiss legislation on dog ownership

    CERN Multimedia

    DSU Department

    2008-01-01

    The Swiss Permanent Mission in Geneva has requested CERN to inform the members of its personnel that a notice relating to Swiss legislation on dog ownership has been published on-line at the following address: http://www.eda.admin.ch/eda/en/home/topics/intorg/un/unge/gepri/pet.html This legislation is applicable to all international civil servants who own a dog. Relations with the Host States Service mailto:relations.secretariat@cern.ch http://www.cern.ch/relations/

  4. License Application Design Selection Feature Report Canistered Assemblies

    International Nuclear Information System (INIS)

    Bennett, Scott M.

    1999-01-01

    The objective of the Modified Waste Emplacement Mode Design Alternative Report is to identify, describe, and evaluate waste package emplacement modes against a specified set of evaluation criteria. This evaluation of the design alternative will be used as input to the decision-making process used to identify the EDAs. The EDAs will, in turn, be evaluated against a set of evaluation criteria, and their evaluations will be used as the basis for an M and O recommendation on the LA design

  5. ITER management advisory committee (MAC) meeting in Naka

    International Nuclear Information System (INIS)

    Yoshikawa, M.

    2000-01-01

    The ITER Management Advisory Committee (MAC) Meeting was held on 28 June 2000 in Moskow, Russia. The main topics were the consideration of the report by the director on the ITER EDA status, the review of the work program, the review of the joint fund, the review of a schedule of ITER meetings and initial discussion and consideration on the disposition of R and D hardware and facilities and other dispositions relating to the termination of the EDA

  6. Evaluation of soluble fraction and enzymatic residual fraction of dilute dry acid, ethylenediamine, and steam explosion pretreated corn stover on the enzymatic hydrolysis of cellulose.

    Science.gov (United States)

    Qin, Lei; Liu, Li; Li, Wen-Chao; Zhu, Jia-Qing; Li, Bing-Zhi; Yuan, Ying-Jin

    2016-06-01

    This study is aimed to examine the inhibition of soluble fraction (SF) and enzymatic residual fraction (ERF) in dry dilute acid (DDA), ethylenediamine (EDA) and steam explosion (SE) pretreated corn stover (CS) on the enzymatic digestibility of cellulose. SF of DDA, EDA and SE pretreated CS has high xylose, soluble lignin and xylo-oligomer content, respectively. SF of EDA pretreated CS leads to the highest inhibition, followed by SE and DDA pretreated CS. Inhibition of ERF of DDA and SE pretreated CS is higher than that of EDA pretreated CS. The inhibition degree (A0/A) of SF is 1.76 and 1.21 times to that of ERF for EDA and SE pretreated CS, respectively. The inhibition degree of ERF is 1.05 times to that of SF in DDA pretreated CS. The quantitative analysis shows that SF of EDA pretreated CS, SF and ERF of SE pretreated CS cause significant inhibition during enzymatic hydrolysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Psychophysiological responses to competition and the big five personality traits.

    Science.gov (United States)

    Binboga, Erdal; Guven, Senol; Catıkkaş, Fatih; Bayazıt, Onur; Tok, Serdar

    2012-06-01

    This study examines the relationship between psychophysiological arousal, cognitive anxiety, and personality traits in young taekwondo athletes. A total of 20 male and 10 female taekwondo athletes (mean age = 18.6 years; ± 1.8) volunteered for the study. The Five Factor Personality Inventory and the state scale of the Spielberger State-Trait Anxiety Inventory (STAI) were used to measure personality and cognitive state anxiety. Electrodermal activity (EDA) was measured twice, one day and approximately one hour prior to the competition, to determine psychophysiological arousal. Descriptive statistics, Pearson product-moment correlations, and stepwise regression were used to analyze the data. Several "Big Five" facets were related to the EDA delta scores that were measured both one day and one hour before the competition. Two stepwise regressions were conducted to examine whether personality traits could significantly predict both EDA delta scores. The final model, containing only neuroticism from the Big Five factors, can significantly explain the variations in the EDA delta scores measured one day before the competition. Agreeableness can significantly explain variations in the EDA delta scores measured one hour before the competition. No relationship was found between cognitive anxiety and the EDA delta scores measured one hour before the competition. In conclusion, personality traits, especially agreeableness and neuroticism, might be useful in understanding arousal responses to competition.

  8. Wearable sensor glove based on conducting fabric using electrodermal activity and pulse-wave sensors for e-health application.

    Science.gov (United States)

    Lee, Youngbum; Lee, Byungwoo; Lee, Myoungho

    2010-03-01

    Improvement of the quality and efficiency of health in medicine, both at home and the hospital, calls for improved sensors that might be included in a common carrier such as a wearable sensor device to measure various biosignals and provide healthcare services that use e-health technology. Designed to be user-friendly, smart clothes and gloves respond well to the end users for health monitoring. This study describes a wearable sensor glove that is equipped with an electrodermal activity (EDA) sensor, pulse-wave sensor, conducting fabric, and an embedded system. The EDA sensor utilizes the relationship between drowsiness and the EDA signal. The EDA sensors were made using a conducting fabric instead of silver chloride electrodes, as a more practical and practically wearable device. The pulse-wave sensor measurement system, which is widely applied in oriental medicinal practices, is also a strong element in e-health monitoring systems. The EDA and pulse-wave signal acquisition module was constructed by connecting the sensor to the glove via a conductive fabric. The signal acquisition module is then connected to a personal computer that displays the results of the EDA and pulse-wave signal processing analysis and gives accurate feedback to the user. This system is designed for a number of applications for the e-health services, including drowsiness detection and oriental medicine.

  9. Carbon nanotubes with silver nanoparticle decoration and conductive polymer coating for improving the electrical conductivity of polycarbonate composites

    KAUST Repository

    Patole, Archana S.

    2015-01-01

    We proposed a strategy to enhance the conductivity of polycarbonate by using three-phase hybrid metallic/non-metallic fillers. Ethylene diamine (EDA) functionalized multiwalled carbon nanotubes (MWCNT-EDA) are first decorated with silver nanoparticles. These Ag/ MWCNT-EDA fillers are then coated with a conductive layer of ethylene glycol treated PEDOT: PSS (poly [3,4-ethylenedioxythiophene]: poly [styrenesulfonate]) (EP). In such an approach, the MWCNT backbone is covered by a highly conductive coating made of Ag nanoparticles surrounded by EP. To understand how Ag and EP form a highly conductive coating, the effect of different wt% of Ag nanoparticles on EP was studied. Ag nanoparticles around the size of 128 ± 28 nmeffectively lowered the volume resistivity of bulk EP, resulting in a highly conducting Ag/EP blend. We found that in the final Ag/MWCNT-EDA/EP assembly, the EP coating enhances the electrical conductivity in two ways: (1) it is an efficient dispersing agent that helps in achieving a uniform dispersion of the Ag/MWCNT-EDA and (2) it acts as a conductive bridge between particles (Ag and MWCNT-EDA), reducing the particle to particle resistivity. When inserted into polycarbonate, this three-phase blend successfully reduced the volume resistivity of the polymer by two orders of magnitude compared with previous approaches.

  10. Enhanced Access Design Alternative I Study

    International Nuclear Information System (INIS)

    Eble, G.B.

    1999-01-01

    The purpose of this document is to evaluate Enhanced Design Alternative (EDA) 1, the low temperature repository design concept (CRWMS M and O 1999a). This technical document will provide supporting information for Site Recommendation (SR) and License Application (LA). Preparation of this evaluation will be in accordance with the technical document preparation plan (TDPP), (CRWMS M and O 1999b). EDA 1, one of five EDAs, was evolved from evaluation of a series of design features and alternatives developed during the first phase of the License Application Design Selection (LADS) process. Low, medium, and high temperature concepts were developed from the design features and alternatives prepared during Phase 1 of the LADS effort (CRWMS M and O 1999a). EDA 1 will first be evaluated against a single Screening Criterion, outlined in CRWMS M and O 1999a, which addresses post-closure performance of the repository. The performance of the repository is defined quantitatively as the peak radiological dose rate to an average individual of a critical group at a distance of 20 km from the repository site within 10,000 years. To satisfy this criterion the peak dose rate must not exceed the anticipated regulatory level of 25 mrem/yr within 10,000 years. If the EDA meets the screening criterion, the EDA will be further evaluated against the LADS Phase 2 Evaluation Criteria contained in CRWMS M and O 1999a

  11. Enhanced Design Alternative I: Low Temperature Design

    International Nuclear Information System (INIS)

    MacNeil, K.

    1999-01-01

    The purpose of this document is to evaluate Enhanced Design Alternative (EDA) 1, the low temperature repository design concept (CRWMS M and O 1999a). This technical document will provide supporting information for Site Recommendation (SR) and License Application (LA). Preparation of this evaluation will be in accordance with the technical document preparation plan (TDPP), (CRWMS M and O 1999b). EDA 1, one of five EDAs, was evolved from evaluation of a series of design features and alternatives developed during the first phase of the License Application Design Selection (LADS) process. Low, medium, and high temperature concepts were developed from the design features and alternatives prepared during Phase 1 of the LADS effort (CRWMS M and O 1999a). EDA 1 will first be evaluated against a single Screening Criterion, outlined in CRWMS M and O 1999a, which addresses post-closure performance of the repository. The performance of the repository is defined quantitatively as the peak radiological dose rate to an average individual of a critical group at a distance of 20 km from the repository site within 10,000 years. To satisfy this criterion the peak dose rate must not exceed the anticipated regulatory level of 25 mrem/yr within 10,000 years. If the EDA meets the screening criterion, the EDA will be further evaluated against the LADS Phase 2 Evaluation Criteria contained in CRWMS M and O 1999a

  12. Multi-functional bio-compatible luminescent apatite with fatty acid passivated nano silver covers and its theranostics potential

    Science.gov (United States)

    Asha, S.; Nimrodh Ananth, A.; Vanitha Kumari, G.; Prakash, B.; Jose, Sujin P.; Jothi Rajan, M. A.

    2017-09-01

    Europium doped hydroxyapatite (EDA) nanorods with linoleic acid passivated silver ions on their surfaces were synthesized using facile, one-step hydrothermal route. Annealing the samples at 250 °C resulted in formation of ultra-small silver (USS) nanoparticles on the surface by nucleation through diffusion process. EDA exhibited luminescence properties due to the presence of europium ions doped on the calcium sites of hydroxyapatite. These EDA nanorods exhibited a different luminescent behavior in the presence of silver ions and USS nanoparticles. This report also demonstrates excellent biocompatibility and cytotoxicity of EDA nanorods with silver ions towards fibroblast cell lines (F929) and breast cancer cells (MCF-7). Visible and near infra-red (NIR) emissions in EDA, induced by silver ions and USS nanoparticles makes it a potential system for deep tissue imaging applications. The arrangement of USS over the EDA was tunable and hence the selectivity and enhancement of the Eu3+ ions emission can also be tuned. The multifunctional properties of this system such as its active luminescence over a wide range, its cell proliferation towards normal cells and cytotoxicity towards cancer cells shows its potential for application in cancer theranostics.

  13. Estimation of distribution algorithm with path relinking for the blocking flow-shop scheduling problem

    Science.gov (United States)

    Shao, Zhongshi; Pi, Dechang; Shao, Weishi

    2018-05-01

    This article presents an effective estimation of distribution algorithm, named P-EDA, to solve the blocking flow-shop scheduling problem (BFSP) with the makespan criterion. In the P-EDA, a Nawaz-Enscore-Ham (NEH)-based heuristic and the random method are combined to generate the initial population. Based on several superior individuals provided by a modified linear rank selection, a probabilistic model is constructed to describe the probabilistic distribution of the promising solution space. The path relinking technique is incorporated into EDA to avoid blindness of the search and improve the convergence property. A modified referenced local search is designed to enhance the local exploitation. Moreover, a diversity-maintaining scheme is introduced into EDA to avoid deterioration of the population. Finally, the parameters of the proposed P-EDA are calibrated using a design of experiments approach. Simulation results and comparisons with some well-performing algorithms demonstrate the effectiveness of the P-EDA for solving BFSP.

  14. Preparation and characterization of aminated graphite oxide for CO2 capture

    International Nuclear Information System (INIS)

    Zhao Yunxia; Ding Huiling; Zhong Qin

    2012-01-01

    Adsorption with solid sorbents is one of the most promising options for postcombustion carbon dioxide (CO 2 ) capture. In this study, aminated graphite oxide used for CO 2 adsorption was synthesized, based on the intercalation reaction of graphite oxide (GO) with amines, including ethylenediamine (EDA), diethylenetriamine (DETA) and triethylene tetramine (TETA). The structural information, surface chemistry and thermal behavior of the adsorbent samples were characterized by X-ray powder diffraction (XRD), infrared spectroscopy (IR), transmission electron microscope (TEM), elemental analysis, particle size analysis, nitrogen adsorption as well as differential thermal and thermogravimetric analysis (DSC-TGA). CO 2 capture was investigated by dynamic adsorption experiments with N 2 -CO 2 mixed gases at 30 °C. The three kinds of graphite oxide samples modified by excess EDA, DETA and TETA showed similar adsorption behaviors seen from their breakthrough curves. Among them, the sample aminated by EDA exhibited the highest adsorption capacity with the longest breakthrough time of CO 2 . Before saturation, its adsorption capacity was up to 53.62 mg CO 2 /g sample. In addition, graphite oxide samples modified by different amount of EDA (EDA/GO raw ratio 10 wt%, 50 wt% and 100 wt%) were prepared in the ethanol. Their CO 2 adsorption performance was investigated. The experimental results demonstrated that graphite oxide with 50 wt% EDA had the largest adsorption capacity 46.55 mg CO 2 /g sample.

  15. Short and Long-Term Outcomes of Epidural or Intravenous Analgesia after Esophagectomy: A Propensity-Matched Cohort Study.

    Directory of Open Access Journals (Sweden)

    Wei Li

    Full Text Available As a well-established technique for postoperative pain relief, the benefits of epidural analgesia (EDA have been under debate recently. This study aimed to determine whether EDA could improve perioperative outcomes and survival in patients undergoing esophagectomy.From January 2010 to December 2012, 587 consecutive cases undergoing McKeown-type esohpageactomy were retrospectively identified from a prospectively maintained database.After propensity-matching, incorporating baseline characteristics, 178 cases were included in each group, and patients characteristics distributions were well-balanced between two groups. Compared with intravenous analgesia, the use of EDA significantly decreased the incidence of pneumonia from 32% to 19.7% (P = 0.008, and anastomotic leakage from 23.0% to 14.0% (P = 0.029. The change in CRP level of EDA group was significantly decreased (preoperative, 6.2 vs. 6.2; POD 1, 108.1 vs. 121.3; POD 3, 131.5 vs. 137.8; POD 7, 69.3 vs. 82.1 mg/L; P = 0.044. EDA patients had a significantly longer duration of indwelling urinary catheter (P<0.001, and lower levels in both systolic (P = 0.001 and diastolic blood pressure (P<0.001. There weren't significant differences in overall survival (log-rank P = 0.47 and recurrence (Gray-test P = 0.46 between two groups.These findings revealed that EDA could attenuate inflammatory response and reduce the incidence of pneumonia and anastomotic leakage after esophagectomy, at the price of delayed urinary catheter removal and lower blood pressure. EDA remains an important component of multimodal perioperative management after esophagectomy.

  16. Effect of immobilized amine density on cadmium(II) adsorption capacities for ethanediamine-modified magnetic poly-(glycidyl methacrylate) microspheres

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Tingting [Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Yang, Liangrong, E-mail: lryang@ipe.ac.cn [Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Pan, Feng; Xing, Huifang; Wang, Li; Yu, Jiemiao [Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Qu, Hongnan [Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China); Rong, Meng [Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Liu, Huizhou, E-mail: hzliu@ipe.ac.cn [Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China)

    2017-04-01

    A series of ethanediamine (EDA) – modified magnetic poly-(glycidyl methacrylate) (m-PGMA-EDA)microspheres with different amine density were synthesized and their cadmium saturation adsorption capacities were examined. The results showed that the cadmium saturation adsorption capacity increased with the immobilized amine density. However, they did not show strong positive linear correlation in the whole range of amine density examined. The molar ratio of amine groups to the adsorbed cadmium decreased with the increase of amine density and eventually reached a minimum value about 4. It suggested that low immobilized amine density led to low coordination efficiency of the amine. It is hypothesized that the immobilized amine groups needed to be physically close enough to form stable amine-metal complex. When the amine density reached to a critical value 1.25 m mol m{sup −2}, stable amine-cadmium complex (4:1 N/Cd) was proposed to form. To illustrate the coordination mechanism (structure and number) of amine and Cd, FT-IR spectra of m-PGMA-EDA and m-PGMA-EDA-Cd , and X-ray photoelectron spectroscopy (XPS) of PGMA–EDA and PGMA-EDA-Cd were examined and analyzed. - Highlights: • A series of magnetic poly-(glycidyl methacrylate) (m-PGMA-EDA)microspheres with different amine density were synthesized and their cadmium saturation adsorption capacities were examined. • The molar ratio of amine groups to adsorbed cadmium decreased with the increase of amine density and eventually reached a minimum value about 4. • when the amine density reached high enough, 4:1 N/Cd complex was proposed to form, and the hydroxyl also participated in the chelating with Cd.

  17. Epidural analgesia during labor among immigrant women in Sweden.

    Science.gov (United States)

    Ekéus, Cecilia; Cnattingius, Sven; Hjern, Anders

    2010-01-01

    To investigate differences in the use of epidural analgesia (EDA) during labor between native Swedish and immigrant women and whether such possible differences could be explained by other maternal factors or birthweight. Population-based register study. Nationwide study in Sweden. A total of 455,274 primiparous women, who gave birth to a singleton infant at 37-41 completed gestational weeks during 1992-2005. Of the 72,086 (16%) immigrants, data on 31,148 women from the eight most common countries of origin were analyzed to test our hypotheses. Register study with perinatal data from the Medical Birth Register and socio-demographic variables from national income and population registers. Use of EDA during vaginal delivery. Compared with native Swedish women, EDA was more often used by women from Chile, odds ratio (OR) 1.39 (95% confidence interval (CI) 1.23-1.57); Iran, OR 1.38 (1.26-1.53); Poland, OR 1.22 (1.08-1.37) and Finland, OR 1.10 (1.03-1.17) after adjustments for perinatal and socio-demographic confounders, while EDA was less often used among women from Somalia, OR 0.57 (0.46-0.70); Iraq, OR 0.71 (0.64-0.78); Turkey, OR 0.77(0.69-0.86) and Yugoslavia, OR 0.85 (0.79-0.91). Having a native Swedish partner increased the use of EDA in immigrant women. EDA use during labor varies more by maternal country of origin than by socio-economic factors. This suggests that expectations of care from the country of origin continue to influence the use of EDA after immigration to Sweden.

  18. Streptozotocin Inhibits Electrophysiological Determinants of Excitatory and Inhibitory Synaptic Transmission in CA1 Pyramidal Neurons of Rat Hippocampal Slices: Reduction of These Effects by Edaravone

    Directory of Open Access Journals (Sweden)

    Ting Ju

    2016-12-01

    Full Text Available Background: Streptozotocin (STZ has served as an agent to generate an Alzheimer's disease (AD model in rats, while edaravone (EDA, a novel free radical scavenger, has recently emerged as an effective treatment for use in vivo and vitro AD models. However, to date, these beneficial effects of EDA have only been clearly demonstrated within STZ-induced animal models of AD and in cell models of AD. A better understanding of the mechanisms of EDA may provide the opportunity for their clinical application in the treatment of AD. Therefore, the purpose of this study was to investigate the underlying mechanisms of STZ and EDA as assessed upon electrophysiological alterations in CA1 pyramidal neurons of rat hippocampal slices. Methods: Through measures of evoked excitatory postsynaptic currents (eEPSCs, AMPAR-mediated eEPSCs (eEPSCsAMPA, evoked inhibitory postsynaptic currents (eIPSCs, evoked excitatory postsynaptic current paired pulse ratio (eEPSC PPR and evoked inhibitory postsynaptic current paired pulse ratio (eIPSC PPR, it was possible to investigate mechanisms as related to the neurotoxicity of STZ and reductions in these effects by EDA. Results: Our results showed that STZ (1000 µM significantly inhibited peak amplitudes of eEPSCs, eEPSCsAMPA and eIPSCs, while EDA (1000 µM attenuated these STZ-induced changes at holding potentials ranging from -60mV to +40 mV for EPSCs and -60mV to +20 mV for IPSCs. Our work also indicated that mean eEPSC PPR were substantially altered by STZ, effects which were partially restored by EDA. In contrast, no significant effects upon eIPSC PPR were obtained in response to STZ and EDA. Conclusion: Our data suggest that STZ inhibits glutamatergic transmission involving pre-synaptic mechanisms and AMPAR, and that STZ inhibits GABAergic transmission by post-synaptic mechanisms within CA1 pyramidal neurons. These effects are attenuated by EDA.

  19. In-situcross-linked PVDF membranes with enhanced mechanical durability for vacuum membrane distillation

    KAUST Repository

    Zuo, Jian; Chung, Neal Tai-Shung

    2016-01-01

    A novel and effective one-step method has been demonstrated to fabricate cross-linked polyvinylidene fluoride (PVDF) membranes with better mechanical properties and flux for seawater desalination via vacuum membrane distillation (VMD). This method involves the addition of two functional nonsolvent additives; namely, water and ethylenediamine (EDA), into the polymer casting solution. The former acts as a pore forming agent, while the latter performs as a cross-linking inducer. The incorporation of water tends to increase membrane flux via increasing porosity and pore size but sacrifices membrane mechanical properties. Conversely, the presence of EDA enhances membrane mechanical properties through in-situ cross-linking reaction. Therefore, by synergistically combining the effects of both functional additives, the resultant PVDF membranes have shown good MD performance and mechanical properties simultaneously. The parameters that affect the cross-link reaction and membrane mechanical properties such as reaction duration and EDA concentration have been systematically studied. The membranes cast from an optimal reaction condition comprising 0.8 wt % EDA and 3-hour reaction not only shows a 40% enhancement in membrane Young's Modulus compared to the one without EDA but also achieves a good VMD flux of 43.6 L/m2-h at 60°C. This study may open up a totally new approach to design next-generation high performance MD membranes. © 2016 American Institute of Chemical Engineers AIChE J, 62: 4013–4022, 2016

  20. [Knocking-out extra domain A alternative splice fragment of fibronectin using a clustered regularly interspaced short palindromic repeats/associated proteins 9 system].

    Science.gov (United States)

    Yang, Yue; Wang, Haicheng; Xu, Shuyu; Peng, Jing; Jiang, Jiuhui; Li, Cuiying

    2015-08-01

    To investigate the effect of the fibronectin extra domain A on the aggressiveness of salivary adenoid cystic carcinoma (SACC) cells, via the clustered regularly interspaced short palindromic repeats (CRISPR)/ associated proteins (Cas) system. One sgRNA was designed to target the upstream of the genome sequences of extra domain A(EDA) exon and the downstream. Then the sgRNA was linked into plasmid PX-330 and transfected into SACC-83 cells. PCR and DNA sequence were used to testify the knockout cells, and the monoclones of EDA absent SACC cells were selected (A+C-2, A+C-6, B+C-10). CCK-8 cell proliferation and invasion was then tested in control group and the experimental group. The sgRNA was successfully linked into PX-330 plasmid. Part of adenoid cystic carcinoma cells' SACC-83 genomic EDA exon was knocked out, and the knockdown efficiency was above 70%, but the total amount of fibronectin did not change significantly. Three monoclones of EDA absent SACC- 83 cells were successfully selected with diminished migration and proliferation. The CRISPR/Cas9 system was a simplified system with relatively high knockout efficiency and EDA knockout could inhibiting SACC cell's mobility and invasiveness.

  1. Effect-directed analysis: Current status and future challenges

    Science.gov (United States)

    Hong, Seongjin; Giesy, John P.; Lee, Jung-Suk; Lee, Jong-Hyeon; Khim, Jong Seong

    2016-09-01

    Effect-directed analysis (EDA) has become useful for identification of toxicant(s) that occur in mixtures in the environment, especially those that are causative agents of specific adverse effects. Here, we summarize and review EDA methodology including preparation of samples, biological analyses, fractionations, and instrumental analyses, highlighting key scientific advancements. A total of 63 documents since 1999 (Scopus search) including 46 research articles, 13 review papers, and 4 project descriptions, have been collected and reviewed in this study. At the early stage (1999-2010), most studies that applied EDA focused on organic extracts of freshwater and coastal contaminated sediments and wastewater. Toxic effects were often measured using cell-based bioassays ( in vitro) and the causative chemicals were identified by use of low resolution gas chromatography with mass selective detector (GCMSD). More recently (2010-present), EDA has been extended to various matrices such as biota, soil, crude oil, and suspended solids and techniques have been improved to include determination of bioavailability in vivo. In particular, methods for non-target screenings of organic chemicals in environmental samples using cutting-edge instrumentation such as time of flight-mass spectrometry (ToF-MS), Fourier transform-ion cyclotron resonance (FT-ICR), and Orbitrap mass spectrometer have been developed. This overview provides descriptions of recent improvements of EDA and suggests future research directions based on current understandings and limitations.

  2. [Adsorption kinetics and mechanism of lead (II) on polyamine-functionalized mesoporous activated carbon].

    Science.gov (United States)

    Li, Kun-Quan; Wang, Yan-Jin; Yang, Mei-Rong; Zhu, Zhi-Qiang; Zheng, Zheng

    2014-08-01

    Bagasse mesoporous carbon was prepared by microwave assisted H3 PO4 activation. Amido and imido groups were modified with ethanediamine on the channels' surface of mesoporous carbon through nitric oxidation and amide reaction. The influence of Pb(II) concentration, adsorption time on Pb(II) adsorption on the ethanediamine-modified mesoporous carbon (AC-EDA) was investigated. The adsorption kinetics and mechanism were also discussed. The results showed that AC-EDA had a great performance for Pb(II) adsorption, and more than 70% of Pb(II) was adsorbed in 5 minutes. The adsorption amount of Pb(II) on the carbon increased with the increase of solution pH in acidic conditions. It was found that AC-EDA had different binding energies on different adsorption sites for Pb(II) separation. The Pb(II) adsorption process on AC-EDA was controlled by intra-particle diffusion in the first 3 min, and then film diffusion played the important pole on the adsorption. The adsorption amount increased with the increase of temperature, indicating the adsorption was an endothermic reaction. The high adsorption energy (> 11 kJ x mol(-1)) implied that the) adsorption was a chemical adsorption. The XPS of AC-EDA before and after Pb(II) adsorption showed that the polyamine group was involved in the adsorption, and should be a main factor of the high efficient adsorption.

  3. Protective Effect of Edaravone against Carbon Monoxide Induced Apoptosis in Rat Primary Cultured Astrocytes

    Directory of Open Access Journals (Sweden)

    Xiaodan Xu

    2017-01-01

    Full Text Available Objective. To observe the protective effect of edaravone (Eda on astrocytes after prolonged exposure to carbon monoxide (CO and further to investigate the potential mechanisms of Eda against CO-induced apoptosis. Methods. The rat primary cultured astrocytes were cultured in vitro and exposed to 1% CO for 24 h after being cultured with different concentrations of Eda. MTT assay was used to detect the cytotoxicity of CO. Flow cytometry was used to detect the apoptosis rate, membrane potential of mitochondria, and ROS level. The mRNA and protein expressions of Bcl-2, Bax, and caspase-3 were assessed by real-time PCR and Western blotting analysis, respectively. Results. Eda can significantly suppress cytotoxicity of CO, and it can significantly increase membrane potential of mitochondria and Bcl-2 expressions and significantly suppress the apoptosis rate, ROS level, Bax, and caspase-3 expressions. Conclusion. Eda protects against CO-induced apoptosis in rat primary cultured astrocytes through decreasing ROS production and subsequently inhibiting mitochondrial apoptosis pathway.

  4. Serial 99mTc-HMPAO Brain SPECT for Assessing Perfusion Improvement after DEAS in Moyamoya Patients

    International Nuclear Information System (INIS)

    Lee, Kyung Han; Lee, Sang Hyung; Yeo, Jeong Seok; Kwark, Chul Eun; Chung, June Key; Lee, Myoung Chul; Cho, Byoung Kyu; Koh, Chang Soon

    1994-01-01

    Encephalo-duro-arterio-synangiosis (EDAS) is a relatively new surgical procedure for treatment of childhood moyamoya disease. We assessed regional cerebral perfusion in moyamoya patients before (1.3 mo) and after (6.8 mo) EDAS with 99m Tc-HMPAO brain SPECT. A total of 21 EDAS operations in 17 moyamoya patients was included. Preoperative CT or MRI showed cerebral infarction in 14 patients and carotid angiography showed Suzuki grade 1 to V stenosis in 6%, 9%, 62%, 12% and 12% of the hemispheres respectively. Preoperative SPECT showed regional hypoperfusion in all patients, bilateral frontal and temporal loves being the most frequently involved site. 4 X 4 pixel sized ROIs were applied on the frontotemmporal cortex in 3 slice averaged transverse tomographic images. An index of regional perfusion was measured as; PI (%)=average FT activity/average cerebellar activity X 100 Pre-EDAS ipsilateral PI ranged from 23.7 to 98.4% (mean:74.3 ± 17%) and increased significantly after operation (81.4 ± 17%, p 90, 0.5) (p<0.001). The amount of perfusion improvement (PI) showed significant correlation with CI (r-0.42, p=0.04). PI did not, however, correlate with the amount of neovascularization assessed angiographically in 8 patients. Serial HMPAO SPECT is an useful noninvasive study for assessing perfusion improvement after EDAS in childhood moyamoya patients.

  5. Total System Performance Assessment: Enhanced Design Alternative V

    International Nuclear Information System (INIS)

    N. Erb; S. Miller; V. Vallikat

    1999-01-01

    This calculation documents the total system performance assessment modeling of Enhanced Design Analysis (EDA) V. EDA V is based on the TSPA-VA base design which has been modified with higher thermal loading, a quartz sand invert, and line loading with 21 PWR waste packages that have 2-cm thick titanium grade 7 corrosion resistance material (CRM) drip shields placed over dual-layer waste packages composed of 'inside out' VA reference material (CRWMS M and O 1999a). This document details the changes and assumptions made to the VA reference Performance Assessment Model (CRWMS M and O 1998a) to incorporate the design changes detailed for EDA V. The performance measure for this evaluation is expected value dose-rate history. Time histories of dose rate are presented for EDA V and a Defense in Depth (DID) analysis base on EDA V. Additional details concerning the Enhanced Design Alternative II are provided in the 'LADS 3-12 Requests' interoffice correspondence (CRWMS M and O 1999a)

  6. Energy Decomposition Analysis Based on Absolutely Localized Molecular Orbitals for Large-Scale Density Functional Theory Calculations in Drug Design.

    Science.gov (United States)

    Phipps, M J S; Fox, T; Tautermann, C S; Skylaris, C-K

    2016-07-12

    We report the development and implementation of an energy decomposition analysis (EDA) scheme in the ONETEP linear-scaling electronic structure package. Our approach is hybrid as it combines the localized molecular orbital EDA (Su, P.; Li, H. J. Chem. Phys., 2009, 131, 014102) and the absolutely localized molecular orbital EDA (Khaliullin, R. Z.; et al. J. Phys. Chem. A, 2007, 111, 8753-8765) to partition the intermolecular interaction energy into chemically distinct components (electrostatic, exchange, correlation, Pauli repulsion, polarization, and charge transfer). Limitations shared in EDA approaches such as the issue of basis set dependence in polarization and charge transfer are discussed, and a remedy to this problem is proposed that exploits the strictly localized property of the ONETEP orbitals. Our method is validated on a range of complexes with interactions relevant to drug design. We demonstrate the capabilities for large-scale calculations with our approach on complexes of thrombin with an inhibitor comprised of up to 4975 atoms. Given the capability of ONETEP for large-scale calculations, such as on entire proteins, we expect that our EDA scheme can be applied in a large range of biomolecular problems, especially in the context of drug design.

  7. A polycarboxylic/amino functionalized hyaluronic acid derivative for the production of pH sensible hydrogels in the prevention of bacterial adhesion on biomedical surfaces.

    Science.gov (United States)

    Palumbo, Fabio Salvatore; Bavuso Volpe, Antonella; Cusimano, Maria Grazia; Pitarresi, Giovanna; Giammona, Gaetano; Schillaci, Domenico

    2015-01-15

    A graft copolymer derivative of hyaluronic acid bearing pendant amino and short polymethacrylate portions (HA-EDA-BMP-MANa) has been employed for the production of a pH sensible vancomycin releasing hydrogel and studied in vitro to test its potential anti adhesive property against Staphylococcus aureus colonization. The copolymer obtained through atom transfer radical polymerization bears chargeable (carboxyl and amino groups) portions and it could be formulated as a hydrogel at a concentration of 10%w/v. The HA-EDA-BMP-MANa hydrogels, produced at three different pH values (5, 6 and 7, respectively), were formulated with or without the addition of vancomycin (2%w/v). The vancomycin release profiles were detected and related to the starting hydrogel pH values, demonstrating that the systems were able to sustain the release of drug for more than 48 h. S. aureus adhesion tests were performed on glass culture plates and hydroxyapatite doped titanium surfaces, comparing the performances of HA-EDA-BMP-MANa hydrogel formulations (obtained with and without vancomycin) with similar formulations obtained using unmodified hyaluronic acid. The non fouling property of a selected HA-EDA-BMP-MANa hydrogel (without vancomycin) was also assayed with a BSA adsorption test. We found that the HA-EDA-BMP-MANa hydrogel even without vancomycin prevented bacterial adhesion on investigated surfaces. Copyright © 2014. Published by Elsevier B.V.

  8. In-situcross-linked PVDF membranes with enhanced mechanical durability for vacuum membrane distillation

    KAUST Repository

    Zuo, Jian

    2016-05-12

    A novel and effective one-step method has been demonstrated to fabricate cross-linked polyvinylidene fluoride (PVDF) membranes with better mechanical properties and flux for seawater desalination via vacuum membrane distillation (VMD). This method involves the addition of two functional nonsolvent additives; namely, water and ethylenediamine (EDA), into the polymer casting solution. The former acts as a pore forming agent, while the latter performs as a cross-linking inducer. The incorporation of water tends to increase membrane flux via increasing porosity and pore size but sacrifices membrane mechanical properties. Conversely, the presence of EDA enhances membrane mechanical properties through in-situ cross-linking reaction. Therefore, by synergistically combining the effects of both functional additives, the resultant PVDF membranes have shown good MD performance and mechanical properties simultaneously. The parameters that affect the cross-link reaction and membrane mechanical properties such as reaction duration and EDA concentration have been systematically studied. The membranes cast from an optimal reaction condition comprising 0.8 wt % EDA and 3-hour reaction not only shows a 40% enhancement in membrane Young\\'s Modulus compared to the one without EDA but also achieves a good VMD flux of 43.6 L/m2-h at 60°C. This study may open up a totally new approach to design next-generation high performance MD membranes. © 2016 American Institute of Chemical Engineers AIChE J, 62: 4013–4022, 2016

  9. Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.

    Science.gov (United States)

    Schneider, Holm; Faschingbauer, Florian; Schuepbach-Mallepell, Sonia; Körber, Iris; Wohlfart, Sigrun; Dick, Angela; Wahlbuhl, Mandy; Kowalczyk-Quintas, Christine; Vigolo, Michele; Kirby, Neil; Tannert, Corinna; Rompel, Oliver; Rascher, Wolfgang; Beckmann, Matthias W; Schneider, Pascal

    2018-04-26

    Genetic deficiency of ectodysplasin A (EDA) causes X-linked hypohidrotic ectodermal dysplasia (XLHED), in which the development of sweat glands is irreversibly impaired, an condition that can lead to life-threatening hyperthermia. We observed normal development of mouse fetuses with Eda mutations after they had been exposed in utero to a recombinant protein that includes the receptor-binding domain of EDA. We administered this protein intraamniotically to two affected human twins at gestational weeks 26 and 31 and to a single affected human fetus at gestational week 26; the infants, born in week 33 (twins) and week 39 (singleton), were able to sweat normally, and XLHED-related illness had not developed by 14 to 22 months of age. (Funded by Edimer Pharmaceuticals and others.).

  10. Aminoalkylated Merrifield Resins Reticulated by Tris-(2-chloroethyl Phosphate for Cadmium, Copper, and Iron (II Extraction

    Directory of Open Access Journals (Sweden)

    Mokhtar Dardouri

    2015-01-01

    Full Text Available We aimed to synthesize novel substituted polymers bearing functional groups to chelate heavy metals during depollution applications. Three polyamine functionalized Merrifield resins were prepared via ethylenediamine (EDA, diethylenetriamine (DETA, and triethylenetetramine (TETA modifications named, respectively, MR-EDA, MR-DETA, and MR-TETA. The aminoalkylated polymers were subsequently reticulated by tris-(2-chloroethyl phosphate (TCEP to obtain new polymeric resins called, respectively, MR-EDA-TCEP, MR-DETA-TCEP, and MR-TETA-TCEP. The obtained resins were characterized via attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR, elemental analysis (EA, and thermogravimetric (TGA, thermodynamic (DTA, and differential thermogravimetric (DTG analysis. The synthesized resins were then assayed to evaluate their efficiency to extract metallic ions such as Cd2+, Cu2+, and Fe2+ from aqueous solutions.

  11. Correlation between the Open-Circuit Voltage and Charge Transfer State Energy in Organic Photovoltaic Cells.

    Science.gov (United States)

    Zou, Yunlong; Holmes, Russell J

    2015-08-26

    In order to further improve the performance of organic photovoltaic cells (OPVs), it is essential to better understand the factors that limit the open-circuit voltage (VOC). Previous work has sought to correlate the value of VOC in donor-acceptor (D-A) OPVs to the interface energy level offset (EDA). In this work, measurements of electroluminescence are used to extract the charge transfer (CT) state energy for multiple small molecule D-A pairings. The CT state as measured from electroluminescence is found to show better correlation to the maximum VOC than EDA. The difference between EDA and the CT state energy is attributed to the Coulombic binding energy of the CT state. This correlation is demonstrated explicitly by inserting an insulating spacer layer between the donor and acceptor materials, reducing the binding energy of the CT state and increasing the measured VOC. These results demonstrate a direct correlation between maximum VOC and CT state energy.

  12. Surface modification of 5083 Al alloy by electrical discharge alloying processing with a 75 mass% Si-Fe alloy electrode

    Energy Technology Data Exchange (ETDEWEB)

    Stambekova, Kuralay [Department of Materials Science and Engineering, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 40227, Taiwan (China); Lin, Hung-Mao [Department of Mechanical Engineering, Far East University, No. 49, Zhonghua Rd., Xinshi Dist., Tainan City 74448, Taiwan (China); Uan, Jun-Yen, E-mail: jyuan@dragon.nchu.edu.tw [Department of Materials Science and Engineering, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 40227, Taiwan (China)

    2012-03-01

    This study experimentally investigates the surface modification of 5083 Al alloy by the electrical discharge alloying (EDA) process with a Si-Fe alloy as an electrode. Samples were analyzed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), micro-hardness and corrosion resistance tests. The micro-hardness of EDA alloyed layer was evidently higher than that of the base metal (5083 Al alloy). The TEM results show that the matrix of the alloyed layer has an amorphous-like structure; the matrix contains fine needle-like Si particles, block-like Si particles and nano-size Al{sub 4.5}FeSi and Al{sub 13}Fe{sub 4} particles. The TEM results support experimental results for the high hardness of the alloyed layer. Moreover, the EDA alloyed layer with composite microstructures has good corrosion resistance in NaCl aqueous solution.

  13. X-linked hypohidrotic ectodermal dysplasia. Genetic and dental findings in 67 Danish patients from 19 families

    DEFF Research Database (Denmark)

    Lexner, Michala Oron; Bardow, A.; Juncker, I.

    2008-01-01

    -chromosome inactivation pattern in female carriers. The study group comprised 67 patients from 19 families (24 affected males and 43 female carriers). All participants had clinical signs of ectodermal dysplasia and a disease-causing EDA mutation. The EDA gene was screened for mutations by single-stranded conformational...... polymorphism and direct sequencing. Multiplex ligation-dependent probe amplification (MLPA) analysis was used to detect deletions/duplications in female probands. Sixteen different EDA mutations were detected in the 19 families, nine not described previously. The MLPA analysis detected a deletion of exon 1...... in one female proband. No genotype-phenotype correlations were observed, and female carriers did not exhibit a skewed X-chromosome inactivation pattern. However, in two female carriers with pronounced clinical symptoms, in whom the parental origin of each allele was known, we observed that mainly...

  14. Amine functionalization of cellulose surface grafted with glycidyl methacrylate by γ-initiated RAFT polymerization

    International Nuclear Information System (INIS)

    Barsbay, Murat; Güven, Olgun; Kodama, Yasko

    2016-01-01

    This study presents the functionalization of poly(glycidyl methacrylate) (PGMA) grafted cellulose filter paper by a model compound, ethylenediamine (EDA), through the epoxy groups of PGMA. Cellulose based copolymers were prepared via the radiation-induced and RAFT-mediated graft polymerization. The samples were characterized by ATR–FTIR spectroscopy, X-ray photoelectron spectroscopy (XPS), elemental analysis, contact angle measurements and scanning electron microscopy (SEM). An efficient modification density of around 1 mmol EDA/mg copolymer was attained within ca. 8 h, indicating that chemical composition of well-defined copolymers may further be tuned by appropriately selecting the reactive agents for use in many emerging fields. - Highlights: • Ethylenediamine (EDA) was immobilized to cellulose-g-PGMA copolymers. • FTIR, XPS, SEM, EA and CA measurements were used for characterization. • The useful qualities of the RAFT were combined with the versatility of PGMA.

  15. Summary of the ITER final design report. July 2001

    International Nuclear Information System (INIS)

    2001-01-01

    This document is a summary of the ITER final design report foreseen during the current, Engineering Design Activities (EDA), phase of the ITER project. The report presents the results of collaborative design and supporting technical work undertaken by the ITER Joint Central team (JCT) and the Home Teams (HT) of the parties to the agreement on co-operation in the Engineering Design Activities for ITER (the ITER EDA Agreement). This report marks the achievement of the full technical scope of activities indicated in the ITER EDA Agreement, with a final design which meets the programmatic objective defined in the Agreement and satisfies detailed scientific, technical and costing objectives set by ITER Council in 1998

  16. An extended continuous estimation of distribution algorithm for solving the permutation flow-shop scheduling problem

    Science.gov (United States)

    Shao, Zhongshi; Pi, Dechang; Shao, Weishi

    2017-11-01

    This article proposes an extended continuous estimation of distribution algorithm (ECEDA) to solve the permutation flow-shop scheduling problem (PFSP). In ECEDA, to make a continuous estimation of distribution algorithm (EDA) suitable for the PFSP, the largest order value rule is applied to convert continuous vectors to discrete job permutations. A probabilistic model based on a mixed Gaussian and Cauchy distribution is built to maintain the exploration ability of the EDA. Two effective local search methods, i.e. revolver-based variable neighbourhood search and Hénon chaotic-based local search, are designed and incorporated into the EDA to enhance the local exploitation. The parameters of the proposed ECEDA are calibrated by means of a design of experiments approach. Simulation results and comparisons based on some benchmark instances show the efficiency of the proposed algorithm for solving the PFSP.

  17. ITER council proceedings: 2000

    International Nuclear Information System (INIS)

    2001-01-01

    No ITER Council Meetings were held during 2000. However, two ITER EDA Meetings were held, one in Tokyo, January 19-20, and one in Moscow, June 29-30. The parties participating in these meetings were those that partake in the extended ITER EDA, namely the EU, the Russian Federation, and Japan. This document contains, a/o, the records of these meetings, the list of attendees, the agenda, the ITER EDA Status Reports issued during these meetings, the TAC (Technical Advisory Committee) reports and recommendations, the MAC Reports and Advice (also for the July 1999 Meeting), the ITER-FEAT Outline Design Report, the TAC Reports and Recommendations both meetings), Site requirements and Site Design Assumptions, the Tentative Sequence of technical Activities 2000-2001, Report of the ITER SWG-P2 on Joint Implementation of ITER, EU/ITER Canada Proposal for New ITER Identification

  18. Measuring Electrodermal Activity to Improve the Identification of Agitation in Individuals with Dementia

    Science.gov (United States)

    Melander, Catharina; Martinsson, Jesper; Gustafsson, Silje

    2017-01-01

    Background Understanding and interpreting the complexity of agitation in people with dementia is challenging. Objective To explore whether a sensor measuring electrodermal activity (EDA) can improve the identification of agitation in individuals with dementia. Methods Nine individuals with dementia wore a sensor that measured EDA. During the same time, assistant nurses annotated the observed behavior of the person with dementia. A binary logistic regression model was applied to assess the relationship between the sensor and the assistant nurses' structured observations of agitation. Results The sensor values correlated with the assistant nurses' observations both at the time of the observation and 1 and 2 h prior to the observation. Conclusion A sensor measuring EDA can support early detection of agitation in persons with dementia. PMID:29430245

  19. MGR External Events Hazards Analysis

    International Nuclear Information System (INIS)

    Booth, L.

    1999-01-01

    The purpose and objective of this analysis is to apply an external events Hazards Analysis (HA) to the License Application Design Selection Enhanced Design Alternative 11 [(LADS EDA II design (Reference 8.32))]. The output of the HA is called a Hazards List (HL). This analysis supersedes the external hazards portion of Rev. 00 of the PHA (Reference 8.1). The PHA for internal events will also be updated to the LADS EDA II design but under a separate analysis. Like the PHA methodology, the HA methodology provides a systematic method to identify potential hazards during the 100-year Monitored Geologic Repository (MGR) operating period updated to reflect the EDA II design. The resulting events on the HL are candidates that may have potential radiological consequences as determined during Design Basis Events (DBEs) analyses. Therefore, the HL that results from this analysis will undergo further screening and analysis based on the criteria that apply during the performance of DBE analyses

  20. Mechanical properties of polyelectrolyte multilayer self-assembled films

    International Nuclear Information System (INIS)

    Dai Xinhua; Zhang Yongjun; Guan Ying; Yang Shuguang; Xu Jian

    2005-01-01

    The mechanical properties of electrostatic self-assembled multilayer films from polyacrylic acid (PAA) and C 60 -ethylenediamine adduct (C 60 -EDA) or poly(allylamine hydrochloride) (PAH) were evaluated by atomic force microscopy (AFM) wear experiments. Because of the higher molecular weight of PAH, the wear resistance of the (PAH/PAA) 10 film is higher than that of the (PAH/PAA) 2 (C 60 -EDA/PAA) 8 film; that is, the former is mechanically more stable than the latter. The mechanical stability of both films can be improved significantly by heat treatment, which changes the nature of the linkage from ionic to covalent. The AFM measurement also reveals that the (PAH/PAA) 2 (C 60 -EDA/PAA) 8 film is softer than the (PAH/PAA) 10 film. The friction properties of the heated films were measured. These films can be developed as potential lubrication coatings for microelectromechanical systems

  1. Evaluation of Effective Diaphragm Area for Pneumatic Actuator

    International Nuclear Information System (INIS)

    Ryu, Hogeun; Han, Bongsub; Seon, Juhyoung

    2016-01-01

    The purpose of this study is to develop a methodology to calculate the exact effective diaphragm area using the results of diagnostic test to be performed in the evaluation of air operated valve performance. By using this developed methodology in pneumatic actuator performance evaluation, it can be reduce the possible errors arising from effective diaphragm area in the evaluation of performance of air operated valves. The performance assessment for the operability and structural integrity of air operated valves for the domestic nuclear power plant is in progress. One of the important parameters that determine the performance of the air operated valves is the effective diaphragm area of diaphragm type actuator. The effective diaphragm area is the actual area which the air pressure acting on the diaphragm. In general, the effective diaphragm area used for the performance evaluation of pneumatic actuator is provided by the manufacture or the actuator drawing. Flat type diaphragm was showed the difference between the measured value of EDA and the manufacture’s value, in the case of convoluted type diaphragm has showed that the measured value of EDA and manufacture’s value is almost the same. When evaluate a performance of a diaphragm actuator, accurate EDA is to be used because it is an important variable affecting the actuator performance. Particularly in the case of flat type diaphragm which EDA is changed in accordance with the stroke position, by using the EDA evaluation methodology developed in this study to minimize a possible error due to EDA when evaluating the performance of the air actuator

  2. Transforming growth factor-β1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation

    International Nuclear Information System (INIS)

    Han Fei; Gilbert, James R.; Harrison, Gerald; Adams, Christopher S.; Freeman, Theresa; Tao Zhuliang; Zaka, Raihana; Liang Hongyan; Williams, Charlene; Tuan, Rocky S.; Norton, Pamela A.; Hickok, Noreen J.

    2007-01-01

    Fibronectin (FN) isoform expression is altered during chondrocyte commitment and maturation, with cartilage favoring expression of FN isoforms that includes the type II repeat extra domain B (EDB) but excludes extra domain A (EDA). We and others have hypothesized that the regulated splicing of FN mRNAs is necessary for the progression of chondrogenesis. To test this, we treated the pre-chondrogenic cell line ATDC5 with transforming growth factor-β1, which has been shown to modulate expression of the EDA and EDB exons, as well as the late markers of chondrocyte maturation; it also slightly accelerates the early acquisition of a sulfated proteoglycan matrix without affecting cell proliferation. When chondrocytes are treated with TGF-β1, the EDA exon is preferentially excluded at all times whereas the EDB exon is relatively depleted at early times. This regulated alternative splicing of FN correlates with the regulation of alternative splicing of SRp40, a splicing factor facilitating inclusion of the EDA exon. To determine if overexpression of the SRp40 isoforms altered FN and FN EDA organization, cDNAs encoding these isoforms were overexpressed in ATDC5 cells. Overexpression of the long-form of SRp40 yielded an FN organization similar to TGF-β1 treatment; whereas overexpression of the short form of SRp40 (which facilitates EDA inclusion) increased formation of long-thick FN fibrils. Therefore, we conclude that the effects of TGF-β1 on FN splicing during chondrogenesis may be largely dependent on its effect on SRp40 isoform expression

  3. Preparation and Characterization of a Cross-linked Matrimid/Polyvinylidene Fluoride Composite Membrane for H2/N2 Separation

    Directory of Open Access Journals (Sweden)

    Mahmood Esmaeilipur

    2017-01-01

    Full Text Available A double layer composite membrane was fabricated by matrimid 5218 as a selective layer on polyvinylidene fluoride (PVDF, a porous asymmetric membrane, as a sublayer. The effect of chemical cross-linking of Matrimid 5218 by ethylenediamine (EDA was investigated on gas transport properties of the corresponding membrane. The permeability levels of hydrogen (H2 and nitrogen (N2 were measured through the fabricated composite membranes at 25°C under pressure range of 2-8 bar. Scanning electron microscopy (SEM was used for morphological observations of the composite membranes. The Matrimid membranes before and after cross-linking modification were characterized by the Fourier transform infrared (FTIR spectroscopy, X-ray diffraction (XRD and density measurement. The FTIR results showed the conversion of imide functional groups into amide through the crosslinking reaction in Matrimid. The XRD results demonstrated a reduction in d-spacing between the polymer chains through cross-linking reaction. Measuring the density of each membrane's partial selective layer and calculating the corresponding fractional free volume revealed an increase in the density and reduced free volumes in Matrimid through the cross-linking reaction. Moreover, by increasing the EDA concentration, the gas permeability in each membrane decreased significantly for nitrogen compared to hydrogen which could be related to lower gas diffusivity through chain packing due to cross-linking of the polymer. The H2/N2 selectivity at 2 bar increased through the cross-linking modification from 56.5 for the pure Matrimid to 79.4 for the composite membrane containing 12 wt% EDA. The effect of pressure on gas permeability through the composite membranes was investigated and the results found to be in agreement with the behavior of less soluble gases in the glassy polymers. Moreover, the H2/N2 selectivity decreased first at low EDA content (0-4 wt%, before reaching a constant value at 8 wt% EDA and

  4. Obstetric and psychological characteristics of women choosing epidural analgesia during labour: A cohort study.

    Science.gov (United States)

    Sitras, Vasilis; Šaltytė Benth, Jūratė; Eberhard-Gran, Malin

    2017-01-01

    To investigate the obstetric and psychological characteristics of women who opt to use epidural analgesia (EDA) during labour and the impact of participating in labour preparation courses on women's decisions to use EDA. Longitudinal cohort study. Akershus University Hospital, Norway. 2596 women with singleton pregnancies and intended vaginal delivery. Data were collected using two self-completed questionnaires at pregnancy weeks 17 and 32. Fear of childbirth was assessed by the Wijma Delivery Expectancy Questionnaire (W-DEQ). Symptoms of anxiety were measured by the Hopkins Symptom Check List (SCL-25) and depression by the Edinburgh Postnatal Depression Scale (EPDS). Obstetric and socio-demographic information was retrieved from birth records at the maternity ward. Preference for EDA was indicated by the questionnaire item "I would prefer an epidural regardless" on a 4-point scale (1 = highly agree, 4 = highly disagree) at pregnancy week 32. Twenty-one percent of the women (540/2596) answered that they would choose EDA as the only alternative method of analgesia during labour. Counselling for fear of childbirth [OR 3.23 (95%CI 2.12; 4.92)] and W-DEQ sum score ≥ 85 [OR 2.95 (95%CI 2.06; 4.23)] were significantly (plabour preparation courses was significantly (p = 0.008) associated with a reduction of intended use of EDA during labour [OR 0.67 (95%CI 0.49; 0.90)]. Fear of childbirth is significantly associated with women's choice of EDA during labour. On the other hand, women that participate in labour preparation courses would rather consider other methods of analgesia during labour.

  5. Synthesis and evaluation of {sup 99m}Tc-labeled folate-tripeptide conjugate as a folate receptor-targeeted imaging agent in a tumor-bearing mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myoung Hyoun; Kim, Chang Guhn; Kim, Dae Weung [Dept. of Nuclear Medicine, Wonkwang University School of Medicine, Iksan (Korea, Republic of); Kim, Woo Hyoung [Dept. of Nuclear Medicine, Seoul National University Hospital, Seoul (Korea, Republic of)

    2015-09-15

    The folate receptor (FR) is an attractive molecular target since it is overexpressed in a variety of human tumors. The purpose of the present study was to synthesize and evaluate the feasibility of a novel {sup 99m}Tc-ECG-EDA (Glu-Cys-Gly-ethylenediamine)-folate as an FR-positive tumor imaging agent in a mouse tumor model. ECG-EDA-folate was synthesized using solid phase peptide synthesis (SPPS) and radiolabeled with {sup 99m}Tc using tripeptide ECG as a chelator. FR-positive KB cells were inoculated in athymic nude mice. Following injection of {sup 99m}Tc-ECG-EDA-folate, serial scintigraphy and micro-SPECT/CT imaging were performed at various time points with and without pre-administration of excess free folate. Mean count densities (MCD) for regions of interest drawn on KB tumors and major normal organs at each time point were measured, and uptake ratios of tumor to normal organs were calculated. ECG-EDA-folate was labeled with {sup 99m}Tc with high radiolabeling efficiency and stability (>96 %). FR-positive tumors were clearly visualized on both scintigraphy and micro-SPECT/CT images and the tumor uptake of {sup 99m}Tc-ECG-EDA-folate was markedly suppressed with faint visualization of tumors by pre-administration of excess free folate on serial planar scintigraphy, indicating FR-specific binding of the agent. Furthermore, semiquantitative analysis of MCD data showed again that both tumor MCD and tumor-to-normal organ ratios decreased considerably by pre-administration of excess free folate, supporting FR-specific tumor uptake. Tumor-to-normal organ ratios approximately increased with time after injection until 4 h. The present study demonstrated that 9{sup 99m}Tc-ECG-EDA-folate can bind specifically to FR with clear visualization of FR-positive tumors in a mouse tumor model.

  6. Electrodermal Activity Is Sensitive to Cognitive Stress under Water.

    Science.gov (United States)

    Posada-Quintero, Hugo F; Florian, John P; Orjuela-Cañón, Alvaro D; Chon, Ki H

    2017-01-01

    When divers are at depth in water, the high pressure and low temperature alone can cause severe stress, challenging the human physiological control systems. The addition of cognitive stress, for example during a military mission, exacerbates the challenge. In these conditions, humans are more susceptible to autonomic imbalance. Reliable tools for the assessment of the autonomic nervous system (ANS) could be used as indicators of the relative degree of stress a diver is experiencing, which could reveal heightened risk during a mission. Electrodermal activity (EDA), a measure of the changes in conductance at the skin surface due to sweat production, is considered a promising alternative for the non-invasive assessment of sympathetic control of the ANS. EDA is sensitive to stress of many kinds. Therefore, as a first step, we tested the sensitivity of EDA, in the time and frequency domains, specifically to cognitive stress during water immersion of the subject (albeit with their measurement finger dry for safety). The data from 14 volunteer subjects were used from the experiment. After a 4-min adjustment and baseline period after being immersed in water, subjects underwent the Stroop task, which is known to induce cognitive stress. The time-domain indices of EDA, skin conductance level (SCL) and non-specific skin conductance responses (NS.SCRs), did not change during cognitive stress, compared to baseline measurements. Frequency-domain indices of EDA, EDASymp (based on power spectral analysis) and TVSymp (based on time-frequency analysis), did significantly change during cognitive stress. This leads to the conclusion that EDA, assessed by spectral analysis, is sensitive to cognitive stress in water-immersed subjects, and can potentially be used to detect cognitive stress in divers.

  7. Electrodermal Activity Is Sensitive to Cognitive Stress under Water

    Directory of Open Access Journals (Sweden)

    Hugo F. Posada-Quintero

    2018-01-01

    Full Text Available When divers are at depth in water, the high pressure and low temperature alone can cause severe stress, challenging the human physiological control systems. The addition of cognitive stress, for example during a military mission, exacerbates the challenge. In these conditions, humans are more susceptible to autonomic imbalance. Reliable tools for the assessment of the autonomic nervous system (ANS could be used as indicators of the relative degree of stress a diver is experiencing, which could reveal heightened risk during a mission. Electrodermal activity (EDA, a measure of the changes in conductance at the skin surface due to sweat production, is considered a promising alternative for the non-invasive assessment of sympathetic control of the ANS. EDA is sensitive to stress of many kinds. Therefore, as a first step, we tested the sensitivity of EDA, in the time and frequency domains, specifically to cognitive stress during water immersion of the subject (albeit with their measurement finger dry for safety. The data from 14 volunteer subjects were used from the experiment. After a 4-min adjustment and baseline period after being immersed in water, subjects underwent the Stroop task, which is known to induce cognitive stress. The time-domain indices of EDA, skin conductance level (SCL and non-specific skin conductance responses (NS.SCRs, did not change during cognitive stress, compared to baseline measurements. Frequency-domain indices of EDA, EDASymp (based on power spectral analysis and TVSymp (based on time-frequency analysis, did significantly change during cognitive stress. This leads to the conclusion that EDA, assessed by spectral analysis, is sensitive to cognitive stress in water-immersed subjects, and can potentially be used to detect cognitive stress in divers.

  8. Verifiable process monitoring through enhanced data authentication

    International Nuclear Information System (INIS)

    Goncalves, Joao G.M.; Schwalbach, Peter; Schoeneman, Barry Dale; Ross, Troy D.; Baldwin, George Thomas

    2010-01-01

    To ensure the peaceful intent for production and processing of nuclear fuel, verifiable process monitoring of the fuel production cycle is required. As part of a U.S. Department of Energy (DOE)-EURATOM collaboration in the field of international nuclear safeguards, the DOE Sandia National Laboratories (SNL), the European Commission Joint Research Centre (JRC) and Directorate General-Energy (DG-ENER) developed and demonstrated a new concept in process monitoring, enabling the use of operator process information by branching a second, authenticated data stream to the Safeguards inspectorate. This information would be complementary to independent safeguards data, improving the understanding of the plant's operation. The concept is called the Enhanced Data Authentication System (EDAS). EDAS transparently captures, authenticates, and encrypts communication data that is transmitted between operator control computers and connected analytical equipment utilized in nuclear processes controls. The intent is to capture information as close to the sensor point as possible to assure the highest possible confidence in the branched data. Data must be collected transparently by the EDAS: Operator processes should not be altered or disrupted by the insertion of the EDAS as a monitoring system for safeguards. EDAS employs public key authentication providing 'jointly verifiable' data and private key encryption for confidentiality. Timestamps and data source are also added to the collected data for analysis. The core of the system hardware is in a security enclosure with both active and passive tamper indication. Further, the system has the ability to monitor seals or other security devices in close proximity. This paper will discuss the EDAS concept, recent technical developments, intended application philosophy and the planned future progression of this system.

  9. H-mode regimes and observators of central toroidal rotation in Alcator C-Mod

    International Nuclear Information System (INIS)

    Greenwald, M.; Rice, J.; Boivin, R.

    1999-01-01

    The Enhanced D α or EDA H-mode regime in Alcator C-Mod has been investigated and compared in detail to ELM-free plasmas. (In this paper, ELM-free will refer to discharges with no type I ELMs and with no sign of EDA, though technically, most EDA plasmas are ELM-free as well.) EDA discharges have only slightly lower energy confinement than comparable ELM-free ones, but show markedly reduced impurity confinement. Thus EDA discharges do not accumulate impurities and typically have a lower fraction of radiated power. EDA plasmas are seen to be more likely at low plasma current (q > 3.7 - 4), for moderate plasma shaping (0.35 - 0.55), and for high neutral pressures. No obvious trends were observed with input power or pressure (β). In both H-mode regimes, and in ICRF heated L-modes, central impurity toroidal rotation has been deduced, from the Doppler shifts of argon x-ray lines. Rotation velocities up to 1.3 x 10 5 m/s in the co-current direction have been observed in H-mode discharges that had no direct momentum input. There is a strong correlation between the increase in the central impurity rotation velocity and the increase in the plasma stored energy, induced by ICRF heating. In otherwise similar discharges with the same stored energy increase, plasmas with lower current rotate faster. The ion pressure gradient is an unimportant contributor to the central impurity rotation and the presence of a substantial core radial electric field is inferred during the ICRF pulse. An inward shift of ions induced by ICRF waves could give rise to a non-ambipolar electric field in the plasma core. Comparisons with a neo-classical ion orbit shift model show good agreement with the observations, both in magnitude, and in the scaling with plasma current. (author)

  10. Phase equilibrium properties of binary aqueous solutions containing ethanediamine, 1,2-diaminopropane, 1,3-diaminopropane, or 1,4-diaminobutane at several temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Nouria Chiali-Baba [LATA2M, Laboratoire de Thermodynamique Appliquee et Modelisation Moleculaire, University AbouBekr Belkaid of Tlemcen, P.O. Box 119, Tlemcen 13000 (Algeria); Negadi, Latifa, E-mail: l_negadi@mail.univ-tlemcen.d [LATA2M, Laboratoire de Thermodynamique Appliquee et Modelisation Moleculaire, University AbouBekr Belkaid of Tlemcen, P.O. Box 119, Tlemcen 13000 (Algeria); Mokbel, Ilham; Jose, Jacques [LSA, Laboratoire des Sciences Analytiques, CNRS-UMR 5180, Universite Claude Bernard - Lyon I. 43, Bd du 11 Novembre 1918, Villeurbanne Cedex 69622 (France)

    2011-05-15

    Research highlights: Vapour pressures of ethanediamine (EDA), 1,2-diaminopropane, 1,3-diaminopropane (1,3-DAP), or 1,4-diaminobutane (1,4-DAB) aqueous solutions are reported between (293 and 363) K. The two first mixtures show negative azeotropic behaviour. The aqueous solutions of EDA, 1,2-DAP, or 1,3-DAP exhibit negative G{sup E} whereas the one containing 1,4-DAB shows either negative G{sup E} or sinusoidal shape for G{sup E}. - Abstract: The vapour pressures of {l_brace}ethanediamine (EDA) + water{r_brace}, {l_brace}1,2-diaminopropane (1,2-DAP) + water{r_brace}, {l_brace}1,3-diaminopropane (1,3-DAP) + water{r_brace} or {l_brace}1,4-diaminobutane (1,4-DAB) + water{r_brace} binary mixtures, and of pure EDA, 1,2-DAP, 1,3-DAP, 1,4-DAB, and water components were measured by means of two static devices at temperatures between (293 and 363) K. The data were correlated with the Antoine equation. From these data, the excess Gibbs function (G{sup E}) was calculated for several constant temperatures and fitted to a fourth-order Redlich-Kister equation using the Barker's method. The {l_brace}ethanediamine (EDA) + water{r_brace}, and {l_brace}1,2-diaminopropane (1,2-DAP) + water{r_brace} binary systems show negative azeotropic behaviour. The aqueous solutions of EDA, 1,2-DAP, or 1,3-DAP exhibit negative deviations in G{sup E} for all investigated temperatures over the whole composition range whereas the (1,4-DAB + water) binary mixture shows negative G{sup E} for temperatures (293.15 < T/K < 353.15) and a sinusoidal shape for G{sup E} at T = 363.15 K.

  11. Evaluation of Effective Diaphragm Area for Pneumatic Actuator

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Hogeun; Han, Bongsub; Seon, Juhyoung [SOOSAN INDUSTRIES, Seoul (Korea, Republic of)

    2016-10-15

    The purpose of this study is to develop a methodology to calculate the exact effective diaphragm area using the results of diagnostic test to be performed in the evaluation of air operated valve performance. By using this developed methodology in pneumatic actuator performance evaluation, it can be reduce the possible errors arising from effective diaphragm area in the evaluation of performance of air operated valves. The performance assessment for the operability and structural integrity of air operated valves for the domestic nuclear power plant is in progress. One of the important parameters that determine the performance of the air operated valves is the effective diaphragm area of diaphragm type actuator. The effective diaphragm area is the actual area which the air pressure acting on the diaphragm. In general, the effective diaphragm area used for the performance evaluation of pneumatic actuator is provided by the manufacture or the actuator drawing. Flat type diaphragm was showed the difference between the measured value of EDA and the manufacture’s value, in the case of convoluted type diaphragm has showed that the measured value of EDA and manufacture’s value is almost the same. When evaluate a performance of a diaphragm actuator, accurate EDA is to be used because it is an important variable affecting the actuator performance. Particularly in the case of flat type diaphragm which EDA is changed in accordance with the stroke position, by using the EDA evaluation methodology developed in this study to minimize a possible error due to EDA when evaluating the performance of the air actuator.

  12. Objective Measurement of Clinical Competency in Surgical Education Using Electrodermal Activity.

    Science.gov (United States)

    Quick, Jacob A; Bukoski, Alex D; Doty, Jennifer; Bennett, Bethany J; Crane, Megan; Barnes, Stephen L

    Within the realm of surgical education, there is a need for objective means to determine surgical competence and resident readiness to operate independently. We propose a novel, objective method of assessing resident confidence and clinical competence based on measurement of electrodermal activity (EDA) during live surgical procedures. We hypothesized that with progressive training, EDA responses to the stress of performing surgery would exhibit decline, elucidating an objective correlate of clinical competence. EDA was measured using galvanic skin response sensors worn by residents performing laparoscopic cholecystectomy on sequential live human patients over an 8-month period. Baseline, phasic (peak) and tonic EDA responses were measured as a fractional change from baseline. University of Missouri, Columbia, Missouri, an academic tertiary care facility. Fourteen categorical general surgery residents and 5 faculty surgeons were voluntarily enrolled and participated through completion. Tonic fractional change (FC TONIC ) was highest in PGY3 residents compared with postgraduate year (PGY) 1 and 2 residents (7.199 vs. 2.100, p = 0.004, 95% CI: 8.58-1.61 and PGY4 and 5 residents (7.199 vs. 2.079, p = 0.002, 95% CI: 8.38-0.29). Phasic fractional change in EDA (FC PHASIC ) exhibited a progressive decline across resident training levels, with PGY1 and 2 residents having the highest response, and faculty displaying the lowest FC PHASIC responses. Statistical differences were seen between FC PHASIC faculty and PGY4 and 5 (3.596 vs. 6.180, p = 0.004, 95% CI: 0.80-4.36), PGY4 and 5, and PGY3 (6.180 vs. 15.998, p = 0.003, 95% CI: 3.33-16.3), as well as among all residents and faculty (13.057 vs. 3.596, p = 0.004, 95% CI: 15.8-3.1). Phasic EDA changes decrease with increasing clinical competence. For those participants with the lowest and highest levels of competence, tonic EDA changes are minimal. Tonic EDA changes follow an inverse-U shape with differing levels of clinical

  13. Anhidrotic ectodermal dysplasia gene region cloned in yeast artificial chromosomes

    Energy Technology Data Exchange (ETDEWEB)

    Kere, J. [Washington Univ. School of Medicine, St. Louis, MO (United States)]|[Univ. of Helsinki (Finland); Grzeschik, K.H. [Univ. of Marburg (Germany); Limon, J. [Medical Academy, Gdansk (Poland); Gremaud, M.; Schlessinger, D. [Washington Univ. School of Medicine, St. Louis, MO (United States); De La Chapelle, A. [Univ. of Helsinki (Finland)

    1993-05-01

    Anhidrotic ectodermal dysplasia (EDA), an X-chromosomal recessive disorder, is expressed in a few females with chromosomal translocations involving bands Xq12-q13. Using available DNA markers from the region and somatic cell hybrids the authors mapped the X-chromosomal breakpoints in two such translocations. The breakpoints were further mapped within a yeast artificial chromosome contig constructed by chromosome walking techniques. Genomic DNA markers that map between the two translocation breakpoints were recovered representing putative portions of the EDA gene. 32 refs., 3 figs., 1 tab.

  14. ITER council proceedings: 1997

    International Nuclear Information System (INIS)

    1997-01-01

    This volume of the ITER EDA Documentation Series presents records of the 12th ITER Council Meeting, IC-12, which took place on 23-24 July, 1997 in Tampere, Finland. The Council received from the Parties (EU, Japan, Russia, US) positive responses on the Detailed Design Report. The Parties stated their willingness to contribute to fulfil their obligations in contributing to the ITER EDA. The summary discussions among the Parties led to the consensus that in July 1998 the ITER activities should proceed for additional three years with a general intent to enable an efficient start of possible, future ITER construction

  15. Tres indigenismos en el parlache: concho, cucha/cucho y tote

    OpenAIRE

    DIANA ANDREA GIRALDO GALLEGO

    2015-01-01

    Si bien el parlache surgió en los barrios populares de la ciudad de Medellín (Vila Rubio & Castañeda Naranjo, 2006) cierto léxico usado dentro de este dialecto social proviene de lenguas indígenas americanas, así como lo exponen Castañeda Naranjo & Henao Salazar (2006) en su Diccionario de parlache. En este artículo presento el análisis de tres indigenismos hallados en el mencionado diccionario con sus respectivas propuestas etimológicas: concho, cucha/cucho y tote . Para la identific...

  16. RT-PCR Analysis of ED-A,ED-B, and IIICS Fibronectin Domains: A New Screening Marker For Bladder Cancer

    Directory of Open Access Journals (Sweden)

    M Ahmadi Javid

    2004-12-01

    Full Text Available Background: Fibronectin seems to play a very important role in the progression and invasion of bladder cancer. EDA, EDB, and IIICS domains of fibronectin are not expressed in the adult persons but they’re expressed in different cancers. The aim of this study is to investigate the mRNA of fibronectin in transitional carcinoma cells (TCC of bladder to study these domains. Methods: A total of 20 patients with known bladder cancer were studied. Two of them excluded since their excised tissues were not enough for both the pathological examination and RNA study. Another 20 (control group were normal volunteers who needed bladder operations. The excised tissue was immediately transferred to RNAlater (Ambion,TX. RNA was extracted via RNAWIZ (Ambion, TX. cDNA was made via RevertAid First Strand cDNA Synthesis Kit (Fermentas. PCR of the cDNAs was performed using primers for EDA, EDB, and IIICS (Eurogentec,Belgium. Results: For the first time, we present the expression of the oncofetal fibronectin mRNA in the transitional cell carcinoma of bladder. The high grade muscle invasive (G3T2 tumor, expressed ED-A, ED-B, and IIICS. Expression of ED-A, ED-B, and IIICS was confirmed in the two patients with G3T1 TCC. The four patients with G2Ta and G3Ta expressed both ED-A and ED-B. The four patients with G1T1 tumor expressed ED-A only, similar to the nine patients with G1Ta tumor. None of the normal volunteers expressed the oncofetal extra domains. The sensitivity of ED-A positive fibronectin RNA for detecting TCC of any kind is 100%, and of ED-B was only 35%. The specificity of ED-B positive fibronectin RNA for the high grade TCC is 100%. Conclusion: ED-A, ED-B, and IIICS could be used as useful markers for the diagnosis and following up of bladder carcinoma. Keywords: Transitional Cell Carcinoma, bladder cancer, fibronectin, RT-PCR, oncofetal.

  17. Three-dimensional integrated circuit design

    CERN Document Server

    Xie, Yuan; Sapatnekar, Sachin S

    2009-01-01

    This book presents an overview of the field of 3D IC design, with an emphasis on electronic design automation (EDA) tools and algorithms that can enable the adoption of 3D ICs, and the architectural implementation and potential for future 3D system design. The aim of this book is to provide the reader with a complete understanding of: the promise of 3D ICs in building novel systems that enable the chip industry to continue along the path of performance scaling, the state of the art in fabrication technologies for 3D integration, the most prominent 3D-specific EDA challenges, along with solutio

  18. Anneteparaad II / Harry Liivrand

    Index Scriptorium Estoniae

    Liivrand, Harry, 1961-

    2008-01-01

    Tutvustatakse Tartu Ülikooli maalikunsti eriala magistri- ja bakalaureuseõppe ning Eesti Kunstiakadeemia vabade kunstide osakonna magistriõppe lõputöid. Lühidalt Andrus Raagi, Katrin Paometsa, Eda Lõhmuse, Edith Karlsoni, Jass Kaselaane, Marge Monko, Maris Palgi, Maria Aderi, Randel Saarma, Natali Pahapilli, Helina Loid-Kudu, Riho Pärna lõputöödest. Eesti Kunstiakadeemia vabade kunstide osakonna magistrandide näitus Kumu Kunstimuuseumis. Tartu Ülikooli maalikunsti eriala magistri Eda Lõhmuse näitus Tartu Kunstimaja Monumentaalkunsti galeriis. Ülikooli maalibakalaureuste näitus Tartu Kunstimuuseumis ning Athena Keskuses

  19. Superconductivity of TiNCl intercalated with diamines

    International Nuclear Information System (INIS)

    Yamanaka, Shoji; Umemoto, Keita

    2010-01-01

    Intercalation compounds of TiNCl with ethylenediamine (EDA) and hexamethylenediamine (HDA) were prepared. The basal spacing of TiNCl increased by 3.3-3.9 A upon intercalation, implying that the molecules are lying with the alkyl chains parallel to the TiNCl layers in both compounds. The intercalated compounds showed superconductivity with transition temperatures (T c s) of 10.5 and 15.5 K for EDA and HDA, respectively, which are higher than 8.6 K of pyridine (Py) intercalated compound, Py 0.25 TiNCl.

  20. Superconductivity of TiNCl intercalated with diamines

    Energy Technology Data Exchange (ETDEWEB)

    Yamanaka, Shoji, E-mail: syamana@hiroshima-u.ac.j [Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan); Umemoto, Keita [Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)

    2010-12-15

    Intercalation compounds of TiNCl with ethylenediamine (EDA) and hexamethylenediamine (HDA) were prepared. The basal spacing of TiNCl increased by 3.3-3.9 A upon intercalation, implying that the molecules are lying with the alkyl chains parallel to the TiNCl layers in both compounds. The intercalated compounds showed superconductivity with transition temperatures (T{sub c}s) of 10.5 and 15.5 K for EDA and HDA, respectively, which are higher than 8.6 K of pyridine (Py) intercalated compound, Py{sub 0.25}TiNCl.

  1. Results of the ITER toroidal field model coil project

    International Nuclear Information System (INIS)

    Salpietro, E.; Maix, R.

    2001-01-01

    In the scope of the ITER EDA one of the seven largest projects was devoted to the development, manufacture and testing of a Toroidal Field Model Coil (TFMC). The industry consortium AGAN manufactured the TFMC based on on a conceptual design developed by the ITER EDA EU Home Team. The TFMC was completed and assembled in the test facility TOSKA of the Forschungszentrum Karlsruhe in the first half of 2001. The first testing phase started in June 2001 and lasted till October 2001. The first results have shown that the main goals of the project have been achieved

  2. ITER central solenoid manufacturing R and D

    International Nuclear Information System (INIS)

    Jay Jayakumar, R.; Tsuji, H.; Ohsaki, O.

    2001-01-01

    The International Thermonuclear Experimental Reactor (ITER) Engineering Design Activity (EDA) includes the development of high performance superconductors, high current joints between superconducting cables and insulating materials. Also in the EDA, the resulting products of this R and D are incorporated in a Central Solenoid Model Coil which utilizes full size conductors. The manufacturing of the model coil and components has led to the development of the design, materials, tooling and process which are fully applicable to the manufacture of the ITER relevant CS coil. The R and D is essentially complete and final stages of the CS Model Coil manufacturing are underway. (author)

  3. ITER central solenoid manufacturing R and D

    International Nuclear Information System (INIS)

    Jayakumar, R.J.; Tsuji, H.; Ohsaki, O.

    1999-01-01

    The International Thermonuclear Experimental Reactor (ITER) Engineering Design Activity (EDA) includes the development of high performance superconductors, high current joints between superconducting cables and insulating materials. Also in the EDA, the resulting products of this R and D are incorporated in a Central Solenoid Model Coil which utilizes full size conductors. The manufacturing of the model coil and components has led to the development of the design, materials, tooling and process which are fully applicable to the manufacture of the ITER relevant CS coil. The R and D is essentially complete and final stages of the CS Model Coil manufacturing are underway. (author)

  4. European Decommissioning Academy

    International Nuclear Information System (INIS)

    Slugen, V. S.; Hornacek, M.

    2016-01-01

    Full text: Experiences from the first run of the European Decommissioning Academy (EDA) are reported in details. EDA was created at the Slovak University of Technology in Bratislava Slovakia, based on discussion and expressed needs declared at many international meetings including ECED2013. The first run successfully passed 15 participants during 7–26 June 2015. Academy was focused on decommissioning issues via lessons, practical exercises in laboratories, on-site training prepared at NPP V-1 in Jaslovské Bohunice, Slovakia as well as four day technical tour to other European decommissioning facilities in Switzerland and Italy. Detailed information can be found at http://kome.snus.sk/inpe/. (author

  5. Report of ITER Special Working Group 2

    International Nuclear Information System (INIS)

    Roberts, M.

    1994-01-01

    ITER Special Working Group 2 (SWG-2) was established by the terms of the ITER-EDA Agreement. According to that agreement, open-quotes SWG-2 shall submit guidelines for implementation of task assignments by the Home Teams to the Council for approval at its second meeting. This SWG shall also draft Protocol 2 to the ITER-EDA Agreement and submit a draft to the Council not later than by 21 May 1993.close quotes The members of SWG-2 for Protocol 2 drafting are listed. The rest of this paper is the verbatim report of SWG-2 on Protocol 2

  6. Enhanced Design Alternative IV

    International Nuclear Information System (INIS)

    Kramer, N.E.

    1999-01-01

    This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the Design Input Request for LADS Phase II EDA Evaluations (CRWMS M and O 1999b) and (CRWMS M and O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as line load. Continuous pre-closure ventilation keeps the waste packages from exceeding their 350 C cladding and 200 C (4.3.6) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and drip shields will be emplaced at closure to improve post-closure performance. The EDA IV concept includes more defense-in-depth layers than the VA reference design because of its backfill, drip shield, waste package shielding, and integral filler features. These features contribute to the low dose-rate to the public achieved during the first 10,000 years of repository life as shown in Figure 3. Investigation of the EDA IV concept has led to the following general conclusions: (1) The total life cycle cost for EDA IV is about $21.7 billion which equates to a $11.3 billion net present value (both figures rounded up). (2) The incidence of design basis events for EDA IV is similar to the VA reference design. (3) The emplacement of the waste packages in drifts will be similar to the VA reference design. However, heavier equipment may be required because the shielded waste package will be heavier. (4) The heavier

  7. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 150 of 253 ... OE Umezinwa. Vol 13, No 1 (2012), Music as Edae: The Implications for Music Therapy in Nigeria, Abstract PDF. CO Aluede ... Vol 15, No 2 (2014), Perspective Actionelle Visa-a-Vis L'enseignement du Français Langue Entrangele au Nigeria : Problem et Vision, Abstract PDF. S Ezeodili. Vol 13, No 2 ...

  8. RIP Input Tables from WAPDEG for LA Design Selection: Enhanced Design Alternative II-3

    International Nuclear Information System (INIS)

    A.M. Monib

    1999-01-01

    The purpose of this calculation is to document (1) the Waste Package Degradation (WAPDEG) version 3.09 (CRWMS M and O 1998b. ''Software Routine Report for WAPDEG'' (Version 3.09)) simulations used to analyze degradation and failure of 2-cm thick titanium grade 7 corrosion resistant material (CRM) drip shields (that are placed over waste packages composed of a 2-cm thick Alloy 22 corrosion resistant material (CRM) as the outer barrier and an unspecified material to provide structural support as the inner barrier) as well as degradation and failure of the waste packages themselves, and (2) post-processing of these results into tables of drip shield/waste package degradation time histories suitable for use as input into the Integrated Probabilistic Simulator for Environmental Systems (RIP) version 5.19.01 (Golder Associates 1998) computer code. This calculation supports Performance Assessment analysis of the License Application Design Selection (LADS) Enhanced Design Alternative (EDA) II-3. The aging period in the EDA II design (CRWMS M and O 1999f. ''Design Input Request for LADS Phase II EDA Evaluations'', Item 1 Row 9 Column 3) was replaced in the case of EDA II-3 with 25 years preclosure ventilation, leading to a total of 50 years preclosure ventilation. The waste packages are line loaded in the repository and no backfill is used

  9. Fusion Canada issue 18

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-08-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on the ITER agreement signed with the EDA, the robotic maintenance for NET, the CFFTP Fusion Pilot Study, the new IEA joint programs on environment, safety and economic aspects of fusion power, and a review by the CCFM advisory committee. 3 figs.

  10. 13 CFR 305.13 - Contract change orders.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Contract change orders. 305.13 Section 305.13 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... all such work will be at the Recipient's risk until EDA completes its review. ...

  11. Download this PDF file

    African Journals Online (AJOL)

    uom

    communication. Since the frequency band width is limited, the optimal assignment problem ... 2 CHANNEL ASSIGNMENT PROBLEM IN CELLULAR RADIO .... Distribution Algorithms” (EDAs) (Larranaga, 2002) helps to make prediction of the ..... chaotic simulated annealing', Lecture Notes in Computer Science, vol. 2084 ...

  12. Removal of Chromium(VI from Aqueous Solutions Using Fe3O4 Magnetic Polymer Microspheres Functionalized with Amino Groups

    Directory of Open Access Journals (Sweden)

    Kai Wang

    2015-12-01

    Full Text Available Magnetic polymer microspheres (MPMs using glycidylmethacrylate (GMA as a functional monomer were synthesized in the presence of Fe3O4 nanoparticles via dispersion polymerization. After polymerization, the magnetic polymer microbeads were modified with ethylenediamine (EDA. The obtained ethylenediamine-functionalized magnetic microspheres (EDA-MPMs were characterized by scanning electron microscope (SEM, X-ray diffraction (XRD, vibrating-sample magnetometer (VSM and Fourier transform infrared (FT-IR spectroscopy. Then the EDA-MPMs were applied as adsorbents for the removal of Cr(VI from aqueous solution. Langmuir equation was appropriate to describe the experimental data. The maximum adsorption capacities obtained from the Langmuir model were 236.9, 242.1 and 253.2 mg/g at 298, 308 and 318 K, respectively. The Cr(VI adsorption equilibrium was established within 120 min and the adsorption kinetics was compatibly described by the pseudo-second order equation. The thermodynamic parameters (ΔG°, ΔH°, ΔS° of the sorption process revealed that the adsorption was spontaneous and was an endothermic process. The regeneration study demonstrated that the EDA-MPMs could be repeatedly utilized with no significant loss of adsorption efficiency.

  13. Incidence of lower thoracic ligamentum flavum midline gaps

    NARCIS (Netherlands)

    Lirk, P.; Colvin, J.; Steger, B.; Colvin, H.-P.; Keller, C.; Rieder, J.; Kolbitsch, C.; Moriggl, B.

    2005-01-01

    Lower thoracic epidural anaesthesia and analgesia (EDA) has gained increasing importance in perioperative pain therapy. The loss-of-resistance technique used to identify the epidural space is thought to rely on the penetration of the ligamentum flavum. Investigations at the cervical and lumbar

  14. ITER council proceedings: 1996

    International Nuclear Information System (INIS)

    1997-01-01

    Records of the 10. ITER Council Meeting (IC-10), held on 26-27 July 1996, in St. Petersburg, Russia, and the 11. ITER Council Meeting (IC-11) held on 17-18 December 1996, in Tokyo, Japan, are presented, giving essential information on the evolution of the ITER Engineering Design Activities (EDA) and the cost review and safety analysis. Figs, tabs

  15. Evidence for the powerful catalytic ability of imidozirconocene ...

    Indian Academy of Sciences (India)

    (3) that has both the β positions blocked by methyl groups undergoes elimination rather than insertion. AIM and. EDA analyses offer further insights on the reaction mechanism and bifunctional reactivity of imidozirconozene complex. Keywords. Imidozirconocene complex; epoxide ring cleavage reaction; density functional ...

  16. Effect-directed analysis supporting monitoring of aquatic ...

    Science.gov (United States)

    Aquatic environments are often contaminated with complex mixtures of chemicals that may pose a risk to ecosystems and human health. This contamination cannot be addressed with target analysis alone but tools are required to reduce this complexity and identify those chemicals that might cause adverse effects. Effect-directed analysis (EDA) is designed to meet this challenge and faces increasing interest in water and sediment quality monitoring. Thus, the present paper summarizes current experience with the EDA approach and the tools required,and provides practical advice on their application. The paper highlights the need for proper problem formulation and gives general advice for study design. As the EDA approach is directed by toxicity, basic principles for the selection of bioassays are given as well as a comprehensive compilation of appropriate assays, includingtheir strengths andweaknesses. A specific focus is given to strategies for sampling, extraction and bioassay dosing since they strongly impact prioritization of toxicants in EDA. Reduction of sample complexity mainly relies onfractionation procedures, which are discussed in this paper, including quality assurance and quality control. Automated combinations of fractionation, biotesting and chemical analysis using so-called hyphenated tools can enhance the throughput and might reduce the risk of artifacts in laboratory work. The key to determiningthe chemical structures causing effects is analytical toxi

  17. 13 CFR 313.8 - Competitive process.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Competitive process. 313.8 Section... § 313.8 Competitive process. (a) Applications for assistance to develop a Strategic Plan or for an implementation grant shall be reviewed by EDA in accord with a competitive process as set forth in the applicable...

  18. 13 CFR 315.16 - Adjustment proposal requirements.

    Science.gov (United States)

    2010-01-01

    .... 315.16 Section 315.16 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT... financial and other supporting documentation as EDA determines is necessary, based upon either: (1) An... generally consists of knowledge-based services such as market penetration studies, customized business...

  19. Fusion Canada issue 18

    International Nuclear Information System (INIS)

    1992-08-01

    A short bulletin from the National Fusion Program. Included in this issue is a report on the ITER agreement signed with the EDA, the robotic maintenance for NET, the CFFTP Fusion Pilot Study, the new IEA joint programs on environment, safety and economic aspects of fusion power, and a review by the CCFM advisory committee. 3 figs

  20. Blood plasma sample preparation method to determine thyroid hormone-disrupting compounds in Effect-Directed Analysis

    NARCIS (Netherlands)

    Simon, E.; Bytingsvik, J.; Jonker, W.; Leonards, P.E.G.; de Boer, J.; Jenssen, B.M.; Lie, E.; Aars, J.; Hamers, T.H.M.; Lamoree, M.H.

    2011-01-01

    A sample preparation method combining solid-phase extraction (SPE) and liquid-liquid extraction (LLE) was developed to be used in Effect-Directed Analysis (EDA) of blood plasma. Until now such a method was not available. It can be used for extraction of a broad range of thyroid hormone

  1. 13 CFR 302.1 - Environment.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Environment. 302.1 Section 302.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.1 Environment. EDA will undertake environmental reviews...

  2. Optimization design for the stepped impedance transformer based on the genetic algorithm

    International Nuclear Information System (INIS)

    Zou Dehui; Lai Wanchang; Qiu Dong

    2007-01-01

    This paper introduces the basic principium and mathematic model of the stepped impedance transformer, then puts the emphasis on comparing two kinds of design methods of the stepped impedance transformer. The design results are simulated by EDA, which indicates that genetic algorithm design is better than Chebyshev integrated design in the term of the most reflect coefficient's module. (authors)

  3. Defence electro-optics: European perspective

    Science.gov (United States)

    Hartikainen, Jari

    2011-11-01

    In 2009 the United States invested in defence R&T 3,6 times and in defence research and development 6,8 times as much as all member states of the European Defence Agency (EDA) combined while the ratio in the total defence expenditure was 2,6 in the US' favour. The European lack of investments in defence research and development has a negative impact on the competitiveness of European defence industry and on the European non-dependence. In addition, the efficiency of investment is reduced due to duplication of work in different member states. The Lisbon Treaty tasks EDA to support defence technology research, and coordinate and plan joint research activities and the study of technical solutions meeting future operational needs. This paper gives an overview how EDA meets the challenge of improving the efficiency of European defence R&T investment with an emphasis on electro-optics and describes shortly the ways that governmental and industrial partners can participate in the EDA cooperation. Examples of joint R&T projects addressing electro-optics are presented.

  4. 13 CFR 301.7 - Investment Assistance proposal.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Investment Assistance proposal... COMMERCE ELIGIBILITY, INVESTMENT RATE AND PROPOSAL AND APPLICATION REQUIREMENTS Proposal and Application Requirements; Evaluation Criteria § 301.7 Investment Assistance proposal. (a) The EDA Investment Assistance...

  5. Deceptive Intentions: Can Cues to Deception Be Measured before a Lie Is Even Stated?

    Directory of Open Access Journals (Sweden)

    Sabine Ströfer

    Full Text Available Can deceitful intentions be discriminated from truthful ones? Previous work consistently demonstrated that deceiving others is accompanied by nervousness/stress and cognitive load. Both are related to increased sympathetic nervous system (SNS activity. We hypothesized that SNS activity already rises during intentions to lie and, consequently, cues to deception can be detected before stating an actual lie. In two experiments, controlling for prospective memory, we monitored SNS activity during lying, truth telling, and truth telling with the aim of lying at a later instance. Electrodermal activity (EDA was used as an indicator of SNS. EDA was highest during lying, and compared to the truth condition, EDA was also raised during the intention to deceive. Moreover, the switch from truth telling toward lying in the intention condition evoked higher EDA than switching toward non-deception related tasks in the lie or truth condition. These results provide first empirical evidence that increased SNS activity related to deception can be monitored before a lie is stated. This implies that cues to deception are already present during the mere intention to lie.

  6. Miks Cannes'is peab käima / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2004-01-01

    57. Cannes'i filmifestivalil nähtud filme - Sembene Ousmane'i "Moolaade" (Senegal), Agnes Jaoui "Vaata mind" (Prantsusmaa), John Nosseiteri dokumentaal "Mondovino" (USA), Pedro Almodovari "Halb haridus" (Hispaania), Emir Kusturica "Elu on ime" (Jugoslaavia/Prantsusmaa), Hirokazu Kore-Eda "Ükski ei tea" (Jaapan). Ka eesti produtsentide tegutsemisest filmiturul

  7. Detection in Urban Scenario Using Combined Airborne Imaging Sensors

    NARCIS (Netherlands)

    Renhorn, I.; Axelsson, M.; Benoist, K.W.; Bourghys, D.; Boucher, Y.; Xavier Briottet, X.; Sergio De CeglieD, S. De; Dekker, R.J.; Dimmeler, A.; Dost, R.; Friman, O.; Kåsen, I.; Maerker, J.; Persie, M. van; Resta, S.; Schwering, P.B.W.; Shimoni, M.; Vegard Haavardsholm, T.

    2012-01-01

    The EDA project “Detection in Urban scenario using Combined Airborne imaging Sensors” (DUCAS) is in progress. The aim of the project is to investigate the potential benefit of combined high spatial and spectral resolution airborne imagery for several defense applications in the urban area. The

  8. Detection in Urban Scenario using Combined Airborne Imaging Sensors

    NARCIS (Netherlands)

    Renhorn, I.; Axelsson, M.; Benoist, K.W.; Bourghys, D.; Boucher, Y.; Xavier Briottet, X.; Sergio De CeglieD, S. De; Dekker, R.J.; Dimmeler, A.; Dost, R.; Friman, O.; Kåsen, I.; Maerker, J.; Persie, M. van; Resta, S.; Schwering, P.B.W.; Shimoni, M.; Vegard Haavardsholm, T.

    2012-01-01

    The EDA project “Detection in Urban scenario using Combined Airborne imaging Sensors” (DUCAS) is in progress. The aim of the project is to investigate the potential benefit of combined high spatial and spectral resolution airborne imagery for several defense applications in the urban area. The

  9. Limbic Irritability, Neuronal Complexity and Smoking

    Czech Academy of Sciences Publication Activity Database

    Svetlak, M.; Bob, P.; Černík, M.; Konečný, P.; Chládek, Jan; Svrček, M.; Kukleta, M.

    2008-01-01

    Roč. 50, č. 3 (2008), s. 85 ISSN 0001-7604. [International CIANS Conference 2008: Higher Brain Functions. 28.09.2008-02.10.2008, Smolenice] Institutional research plan: CEZ:AV0Z20650511 Keywords : smoking * limbic irritability * stress * complexity * EDA Subject RIV: FH - Neurology

  10. Lõhmus pluss Mäetamm pluss Külm / Anneli Porri

    Index Scriptorium Estoniae

    Porri, Anneli, 1980-

    2005-01-01

    Eda Lõhmuse maalinäitus "Reaalne. Ebareaalne" Tallinna Linnagaleriis 7.-16. I. Neeme Külma näitus "Kui" Hobusepea galeriis 22. XII 2004-3. I 2005. Marko Mäetamme "Mälestusnäitus" Tallinna Linnagaleriis 20. XII 2004-10. I 2005

  11. Vanapagan ja Kaval-Ants / Urve Karuks ; fotod: V. Sarapuu

    Index Scriptorium Estoniae

    Karuks, Urve, 1936-2015

    2006-01-01

    lugemisteatri ILUTULI etendusest 8. märtsil 2006 Tartu Collegeì saalis. Lavastaja Killi Mirka, korraldus Aarne H. Vahtra, kunstnik Eva Oja, valgustus Vaado Sarapuu. Osatäitjad: Eda Oja, Leiki Veskimets, Kaljo Anja, Veikko Kalep, Mart Pikkov, Eerik Purje, Siegfried Preem ja Volli Palo

  12. Kumus näeb maailmamuutjaid / Helen Teesalu

    Index Scriptorium Estoniae

    Teesalu, Helen

    2008-01-01

    Maailmamuutjate filmifestival näitab neljal järjestikusel kolmapäeval dokfilme eriliste inimeste erilistest ettevõtmistest. Täna on Kumus Chema Rodrigueze "Raudtee tähed", mida kommenteerivad Eda Mölder ja Artur Taevere

  13. 13 CFR 304.4 - Performance evaluations.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Performance evaluations. 304.4... ECONOMIC DEVELOPMENT DISTRICTS § 304.4 Performance evaluations. (a) EDA shall evaluate the management... of at least one (1) other District Organization in the performance evaluation on a cost-reimbursement...

  14. 17. IAEA fusion energy conference. Extended synopses

    International Nuclear Information System (INIS)

    1998-01-01

    Book of extended synopses of the papers, accepted by a international programme committee for presentation at the 17th IAEA Fusion Energy Conference in Yokohama, Japan. The subjects covered are magnetic confinement experiments, plasma heating and current drive, ITER EDA, inertial fusion energy, innovative concepts, fusion technology and theory

  15. Vanemuislased jagasid oma majja tunnustust

    Index Scriptorium Estoniae

    2010-01-01

    Vanemuise loomenõukogu jagas aastaauhindu. Autospiriti-nimeline draamaauhind läks Maarja Mittile, Torrese-nimelise balletiauhinna sai Colin Thomas Maggs, Kinema-nimelise tehnilise töötaja auhinna sai Jaan Koiduaru, loomenõukogu eripreemia sai trupijuht Eda Hinno ning haldustöötaja müügiassistendi preemia Sanna Pindma. Samuti jagati kolleegipreemiaid

  16. The effect of solvent swelling for the production of ashless coal

    Energy Technology Data Exchange (ETDEWEB)

    Aylin Kurman; Sultan Giray; Ozgur Sonmez [Cukurova University, Adana (Turkey). Chemistry Department, Art& Science Faculty

    2005-07-01

    Two Turkish coal (a bituminous and a brown coal) were extracted with NMP-CS2 (1:1 v/v) and NMP-EDA (1:17, v/v) at room conditions and with NMP and NMP/EDA under reflux. To obtain any effect of solvent swelling on extraction yield coals were also extracted at same conditions after swelling with NMP and EDA. The extraction yield was maximum in the NMP-CS2 mixed solvent for higher ranked coal, suggesting a synergistic effect of the system. It was possible to extract over 35 % of sub-bituminous coal by using NMP- CS2. The extraction of same coal with NMP under reflux gave an extraction yield of 33% suggesting the useful effect of solvent swelling and heat during the reflux period. A positive effect of pre-swelling with NMP and EDA on extraction yield and recovery of solid extracts were observed , especially for brown coal sample. Following the extraction, solid extracts were produced with less than 0.12 % in ash content for almost all extraction conditions.

  17. Synthesis of electric discharge alloyed nickel–tungsten coating on tool steel and its tribological studies

    International Nuclear Information System (INIS)

    Arun, Ilangovan; Duraiselvam, Muthukannan; Senthilkumar, V.; Narayanasamy, R.; Anandakrishnan, V.

    2014-01-01

    Highlights: • Electrical discharge alloying/coating made on AISI D2 tool steel. • The hardness of EDA layer is three to four time higher than the base material. • The dry sliding wear tests performed on EDA layer at different temperatures. • The alloyed layer acts as a self-lubricant at higher temperature. - Abstract: The present study examines the method of depositing nickel and tungsten on die steel surface by means of dispersing these elements in dielectric fluid in an electrical discharge alloying (EDA) process. The modified surface was mechanically and metallurgically characterized using Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray spectroscopy (EDX), microhardness tester and Pin-on-disc tribometer. The phase transformations that occurred during EDA process were evaluated by XRD. The deposition of Ni and W on die steel surfaces yielded minimal cracks with excellent metallurgical bonding. Higher hardness (∼1059 HV 0.3 ) with little brittleness resulted in superior wear resistance properties, a property which was retained even at elevated temperature

  18. Pollution-Induced Community Tolerance To Diagnose Hazardous Chemicals in Multiple Contaminated Aquatic Systems.

    Science.gov (United States)

    Rotter, Stefanie; Gunold, Roman; Mothes, Sibylle; Paschke, Albrecht; Brack, Werner; Altenburger, Rolf; Schmitt-Jansen, Mechthild

    2015-08-18

    Aquatic ecosystems are often contaminated with large numbers of chemicals, which cannot be sufficiently addressed by chemical target analyses. Effect-directed analysis (EDA) enables the identification of toxicants in complex contaminated environmental samples. This study suggests pollution-induced community tolerance (PICT) as a confirmation tool for EDA to identify contaminants which actually impact on local communities. The effects of three phytotoxic compounds local periphyton communities, cultivated at a reference (R-site) and a polluted site (P-site), were assessed to confirm the findings of a former EDA study on sediments. The sensitivities of R- and P-communities to prometryn, tributyltin (TBT) and N-phenyl-2-naphthylamine (PNA) were quantified in short-term toxicity tests and exposure concentrations were determined. Prometryn and PNA concentrations were significantly higher at the P-site, whereas TBT concentrations were in the same range at both sites. Periphyton communities differed in biomass, but algal class composition and diatom diversity were similar. Community tolerance of P-communities was significantly enhanced for prometryn, but not for PNA and TBT, confirming site-specific effects on local periphyton for prometryn only. Thus, PICT enables in situ effect confirmation of phytotoxic compounds at the community level and seems to be suitable to support confirmation and enhance ecological realism of EDA.

  19. Affective Man-Machine Interface: Unveiling human emotions through biosignals

    NARCIS (Netherlands)

    van den Broek, Egon; Lisy, Viliam; Janssen, Joris H.; Westerink, Joyce H.D.M.; Schut, Marleen H.; Tuinenbreijer, Kees; Fred, A.; Filipe, J.; Gamboa, H.

    2010-01-01

    As is known for centuries, humans exhibit an electrical profile. This profile is altered through various psychological and physiological processes, which can be measured through biosignals; e.g., electromyography (EMG) and electrodermal activity (EDA). These biosignals can reveal our emotions and,

  20. Iglesia y poder público. Actas del VII Simposio de Historia de la Iglesia en España y América (Reseña)

    OpenAIRE

    Tineo, P. (Primitivo)

    1998-01-01

    Reseña del libro de Paulino CASTAÑEDA-Manuel J. COCINA Y ABELLA (coords.), Iglesia y poder público. Actas del VII Simposio de Historia de la Iglesia en España y América, Academia de Historia Eclesiástica, Obra social y cultural Cajasur, Córdoba 1997, 308 pp.

  1. Molecular and Therapeutic Characterization of Anti-ectodysplasin A Receptor (EDAR) Agonist Monoclonal Antibodies*

    Science.gov (United States)

    Kowalczyk, Christine; Dunkel, Nathalie; Willen, Laure; Casal, Margret L.; Mauldin, Elizabeth A.; Gaide, Olivier; Tardivel, Aubry; Badic, Giovanna; Etter, Anne-Lise; Favre, Manuel; Jefferson, Douglas M.; Headon, Denis J.; Demotz, Stéphane; Schneider, Pascal

    2011-01-01

    The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. In this study, several agonist anti-EDAR monoclonal antibodies were generated that cross-react with the extracellular domains of human, dog, rat, mouse, and chicken EDAR. Their half-life in adult mice was about 11 days. They induced tail hair and sweat gland formation when administered to newborn EDA-deficient Tabby mice, with an EC50 of 0.1 to 0.7 mg/kg. Divalency was necessary and sufficient for this therapeutic activity. Only some antibodies were also agonists in an in vitro surrogate activity assay based on the activation of the apoptotic Fas pathway. Activity in this assay correlated with small dissociation constants. When administered in utero in mice or at birth in dogs, agonist antibodies reverted several ectodermal dysplasia features, including tooth morphology. These antibodies are therefore predicted to efficiently trigger EDAR signaling in many vertebrate species and will be particularly suited for long term treatments. PMID:21730053

  2. Annual report of Naka Fusion Research Establishment. From April 1, 1995 to March 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Michiya; Asakura, Nobuyuki; Moriyama, Shinichi; Yamanishi, Toshihiko; Seki, Masahiro; Takahashi, Ichiro [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; eds.

    1996-11-01

    This report provides an overview of research and development activities at Naka Fusion Research Establishment, JAERI, during the period from April 1, 1995 to March 31, 1996. The activities in Naka Fusion Research Establishment are highlighted by high-temperature plasma research in JT-60U and JFT-2M, and progress in ITER-EDA, including technology development. (author)

  3. Stress-induced alterations of left-right electrodermal activity coupling indexed by pointwise transinformation.

    Science.gov (United States)

    Světlák, M; Bob, P; Roman, R; Ježek, S; Damborská, A; Chládek, J; Shaw, D J; Kukleta, M

    2013-01-01

    In this study, we tested the hypothesis that experimental stress induces a specific change of left-right electrodermal activity (EDA) coupling pattern, as indexed by pointwise transinformation (PTI). Further, we hypothesized that this change is associated with scores on psychometric measures of the chronic stress-related psychopathology. Ninety-nine university students underwent bilateral measurement of EDA during rest and stress-inducing Stroop test and completed a battery of self-report measures of chronic stress-related psychopathology. A significant decrease in the mean PTI value was the prevalent response to the stress conditions. No association between chronic stress and PTI was found. Raw scores of psychometric measures of stress-related psychopathology had no effect on either the resting levels of PTI or the amount of stress-induced PTI change. In summary, acute stress alters the level of coupling pattern of cortico-autonomic influences on the left and right sympathetic pathways to the palmar sweat glands. Different results obtained using the PTI, EDA laterality coefficient, and skin conductance level also show that the PTI algorithm represents a new analytical approach to EDA asymmetry description.

  4. 13 CFR 313.6 - Strategic Plans.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Strategic Plans. 313.6 Section 313... § 313.6 Strategic Plans. (a) General. An Impacted Community that intends to apply for a grant for implementation assistance under § 313.7 shall develop and submit a Strategic Plan to EDA for evaluation and...

  5. 77 FR 42696 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-07-20

    .... Affected Public: Current recipients of EDA assistance, to include (1) cities or other political... infrastructure development activities, or a consortium of political subdivisions; (2) states; (3) institutions of higher education or a consortium of institutions of higher education; (4) public or private non-profit...

  6. 75 FR 27992 - Solicitation of Applications for the Research and Evaluation Program: FY 2010 Mapping Regional...

    Science.gov (United States)

    2010-05-19

    ... for an economic development research project aimed at developing a replicable method for identifying... innovation: (i) Indiana Business Research Center's Innovation Index (available at http://www.statsamerica.org... will brief EDA senior management on research methods and report results. Cost Sharing Requirement...

  7. Challenges in effect-directed analysis with a focus on biological samples

    NARCIS (Netherlands)

    Simon, E.; Lamoree, M.H.; Hamers, T.; de Boer, J.

    2015-01-01

    Effect-directed analysis (EDA), the combined use of bioassay-guided fractionation and analytical chemical techniques, enables detection of chemicals by their effects, facilitates identification of non-target compounds and transformation products with a certain toxic mode of action and assists in

  8. Future electro-optical sensors and processing in urban operations

    NARCIS (Netherlands)

    Grönwall, C.; Schwering, P.B.; Rantakokko, J.; Benoist, K.W.; Kemp, R.A.W.; Steinvall, O.; Letalick, D.; Björkert, S.

    2013-01-01

    In the electro-optical sensors and processing in urban operations (ESUO) study we pave the way for the European Defence Agency (EDA) group of Electro-Optics experts (IAP03) for a common understanding of the optimal distribution of processing functions between the different platforms. Combinations of

  9. Benchmarking Parameter-free AMaLGaM on Functions With and Without Noise

    NARCIS (Netherlands)

    P.A.N. Bosman (Peter); J. Grahl; D. Thierens (Dirk)

    2013-01-01

    htmlabstractWe describe a parameter-free estimation-of-distribution algorithm (EDA) called the adapted maximum-likelihood Gaussian model iterated density-estimation evolutionary algorithm (AMaLGaM-IDEA, or AMaLGaM for short) for numerical optimization. AMaLGaM is benchmarked within the 2009 black

  10. Neural chaos and schizophrenia

    Czech Academy of Sciences Publication Activity Database

    Bob, P.; Chládek, Jan; Šusta, M.; Glaslová, K.; Jagla, F.; Kukleta, M.

    2007-01-01

    Roč. 26, č. 4 (2007), s. 298-305 ISSN 0231-5882 Institutional research plan: CEZ:AV0Z20650511 Keywords : EDA * Lyapunov exponent * schizophrenia * chaos Subject RIV: FL - Psychiatry, Sexuology Impact factor: 1.286, year: 2007

  11. Structural and optical study of CaF{sub 2} nanoparticles produced by a microwave-assisted hydrothermal method

    Energy Technology Data Exchange (ETDEWEB)

    Bezerra, Claudiane dos S., E-mail: cdsantos20@gmail.com; Valerio, Mário E.G.

    2016-11-15

    CaF{sub 2} nanoparticles were synthesized by the microwave-assisted hydrothermal method. With the addition of the ethylenediamine (EDA) as chelating agent, the size of the particles was reduced. The CaF{sub 2} exhibit single phase identified for X-ray diffraction (XRD) and confirmed by Rietveld refinement. Scanning electron microscopy (SEM) images showed nanoparticles with non-uniform morphology and statistical analysis of collections of particles reviewed that the EDA decreases both the average particle size and average aspect ratio of the particles. The chemical composition of the surface of the particles was investigated by X-ray Photoelectron Spectroscopy (XPS) and the results indicated the presence of reasonable amounts of hydroxyl groups and oxygen ions in the samples produced with EDA. Radioluminescence (RL) measurements showed that both types of nanoparticles presented intrinsic scintillation emission formed by two main bands and that the CaF{sub 2} samples produced without EDA presented higher emission intensity. The broad RL band centered at approximately 293 nm is related to self-trapped exciton (STE) emission of calcium fluoride, while the band at 428 nm can be due to the presence of F centers. The STE excitation and optical band gap were measured through photoluminescent excitation spectra in the VUV range.

  12. Future flare compositions

    NARCIS (Netherlands)

    Lingen, J.L.N. van; Meuken, D.; Hackspik, M.M.; Mäkeläinen, T.; Weiser, V.; Poulson, G.W.

    2014-01-01

    This poster describes the work done within the Category B joint research project under the European Defence Agency (EDA) on Future Flare Compositions [1]. Contributing members were Finland, Germany, United Kingdom and the Netherlands. The program was aimed to identify the technology gaps that apply

  13. Sleep Deprivation in Young and Healthy Subjects Is More Sensitively Identified by Higher Frequencies of Electrodermal Activity than by Skin Conductance Level Evaluated in the Time Domain

    Directory of Open Access Journals (Sweden)

    Hugo F. Posada-Quintero

    2017-06-01

    Full Text Available We analyzed multiple measures of the autonomic nervous system (ANS based on electrodermal activity (EDA and heart rate variability (HRV for young healthy subjects undergoing 24-h sleep deprivation. In this study, we have utilized the error awareness test (EAT every 2 h (13 runs total, to evaluate the deterioration of performance. EAT consists of trials where the subject is presented words representing colors. Subjects are instructed to press a button (“Go” trials or withhold the response if the word presented and the color of the word mismatch (“Stroop No-Go” trial, or the screen is repeated (“Repeat No-Go” trials. We measured subjects' (N = 10 reaction time to the “Go” trials, and accuracy to the “Stroop No-Go” and “Repeat No-Go” trials. Simultaneously, changes in EDA and HRV indices were evaluated. Furthermore, the relationship between reactiveness and vigilance measures and indices of sympathetic control based on HRV were analyzed. We found the performance improved to a stable level from 6 through 16 h of deprivation, with a subsequently sustained impairment after 18 h. Indices of higher frequencies of EDA related more to vigilance measures, whereas lower frequencies index (skin conductance leve, SCL measured the reactiveness of the subject. We conclude that indices of EDA, including those of the higher frequencies, termed TVSymp, EDASymp, and NSSCRs, provide information to better understand the effect of sleep deprivation on subjects' autonomic response and performance.

  14. 2551-IJBCS-Article-Innocent D Y Ahemidé

    African Journals Online (AJOL)

    hp

    l'asthme, la migraine et l'ictère (Akoègninou et al., 2006; Esimone et al., 2007). Sur le plan ..... 20Pdf/2013/October/101013896%20Eda gbo%20et20al.pdf. Ekhaise OF, Agboh MK, Uanseoje S. 2010. Evaluation of the Methanolic Extract of. Mistletoe (Tapinanthus bangwensis). Leaves Grown on Orange Trees for the.

  15. Weather. European Theater Weather Orientation (ETWO)

    Science.gov (United States)

    1992-11-01

    EGUL RAF Lakenheath KBKF Buckdey CO EGUN RAF Mildenhall KSAW Sawyer MI EDAS Sembach GM KGRF Ft Lewis WA EDAB Bitburg GM KFRI Ft Riley KS EDAT...Stability Idez (2) The following list shows the bulletin headers with stations included on each FJ•UEO EDEX EDIC EDIN EDOP EDID EDOT FUE51 EGUA EGUN

  16. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    We carried out extensive simulation studies to assess the proposed method. ... transmission dynamics and life history characteristics in parasite populations .... A novel missense mutation in collagenous domain of EDA gene in a ... Importance of molecular diagnosis in the accurate diagnosis of systemic carnitine deficiency.

  17. Remembering San Diego

    International Nuclear Information System (INIS)

    Chuyanov, V.

    1999-01-01

    After 6 years of existence the ITER EDA project in San Diego, USA, was terminated by desition of the US Congress. This article describes how nice it was for everybody as long as it lasted and how sad it is now

  18. The European computer model for optronic system performance prediction (ECOMOS)

    NARCIS (Netherlands)

    Kessler, S.; Bijl, P.; Labarre, L.; Repasi, E.; Wittenstein, W.; Bürsing, H.

    2017-01-01

    ECOMOS is a multinational effort within the framework of an EDA Project Arrangement. Its aim is to provide a generally accepted and harmonized European computer model for computing nominal Target Acquisition (TA) ranges of optronic imagers operating in the Visible or thermal Infrared (IR). The

  19. Latinamerikas politiske venstredrejning

    DEFF Research Database (Denmark)

    Christensen, Steen Fryba; Andersson, Vibeke

    2006-01-01

    Artiklen diskuterer, hvordan man skal forstå Latinamerikas politiske venstredrejning i starten af det 21 årh. Jorge Castañedas inddeling i to typer venstrefløje er omdrejningspunktet for analysen. Fokus i artiklen er på Bolivia og Brasilien, der typisk ses som tilhørende hver sin type venstrefløj....

  20. Glassy carbon electrode modified with polyanilne/ethylenediamine for detection of copper ions

    Science.gov (United States)

    Patil, Harshada K.; Deshmukh, Megha A.; Bodkhe, Gajanan A.; Shirsat, Mahendra D.

    2018-05-01

    Increasing water pollution is having high concern, since it creates the threats to all leaving organisms of existence. Industrial sewages have not only polluted the main stream lines of water, also the ground level water is having serious contaminations. Heavy metal ions are the pollutants which are not degradable and can be accumulated on living things ultimately the excess accumulation results into the serious concerns. Therefore, it is necessary to develop the sensors which can detect the heavy metal ions up to its maximum contamination limits. Conducting polymers are the materials which possess large application spectra. This investigation reports the electrochemically synthesized polyaniline (PANI) for modification of glassy carbon electrode (GCE). Ethylenediamine (EDA) - chelating ligand used for the modification of polyaniline so as to inculcate the selectivity toward copper ions Cu (II). The electrochemical cyclic voltammetry (CV) was used for the study of redox characteristics of PANI and influence of EDA modification. The result of CV has shown the reduced oxidation and reduction peak currents after modification indicating the domination of EDA. GCE modified with PANI/EDA was then employed for the detection of divalent copper ions and have shown the affinity toward Cu ions. The detection limit achieved was equal to 10mg/lit.

  1. Benchmarking in digital circuit design automation

    NARCIS (Netherlands)

    Jozwiak, L.; Gawlowski, D.M.; Slusarczyk, A.S.

    2008-01-01

    This paper focuses on benchmarking, which is the main experimental approach to the design method and EDA-tool analysis, characterization and evaluation. We discuss the importance and difficulties of benchmarking, as well as the recent research effort related to it. To resolve several serious

  2. Nuclear analysis for ITER

    International Nuclear Information System (INIS)

    Santoro, R.T.; Iida, H.; Khripunov, V.; Petrizzi, L.; Sato, S.; Sawan, M.; Shatalov, G.; Schipakin, O.

    2001-01-01

    This paper summarizes the main results of nuclear analysis calculations performed during the International Thermonuclear Experimental Reactor (ITER) Engineering Design Activity (EDA). Major efforts were devoted to fulfilling the General Design Requirements to minimize the nuclear heating rate in the superconducting magnets and ensuring that radiation conditions at the cryostat are suitable for hands-on-maintenance after reactor shut-down. (author)

  3. Arthur Prior and 'Now'

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Jørgensen, Klaus Frovin

    2016-01-01

    ’s search led him through the work of Castañeda, and back to his own work on hybrid logic: the first made temporal reference philosophically respectable, the second made it technically feasible in a modal framework. With the aid of hybrid logic, Prior built a bridge from a two-dimensional UT calculus...

  4. "Laulukarusselli" võitis Tartu tüdruk

    Index Scriptorium Estoniae

    2008-01-01

    Tänavuse ETV laste lauluvõistluse"Laulukarussell" võitis kaheksa-aastane Pauline Vähi, võitja valis žürii kooseisus Eri Klas, Heidy Tamme, Silvi Vrait, Tõnu Kaljuste, Eda-Ines Etti, Koit Toome ja Kristjan Kasearu

  5. Design for manufacturability and yield for nano-scale CMOS

    CERN Document Server

    Chiang, Charles C

    2007-01-01

    Talks about the various aspects of manufacturability and yield in a nano-CMOS process and how to address each aspect at the proper design step starting with the design and layout of standard cells. This book is suitable for practicing IC designer and for graduate students intent on having a career in IC design or in EDA tool development.

  6. Non-parallel divergence across Danish freshwater and marine three-spined stickleback Gasterosteus aculeatus populations

    DEFF Research Database (Denmark)

    Pujolar, José Martin; Ferchaud, Anne-Laure; Bekkevold, Dorte

    2017-01-01

    at 13 sampling locations were screened for genetic variation using a combination of 70 genes putatively under selection and 26 neutral genes along with a marker linked to the ectodysplasin gene(eda), which is strongly correlated with plate armour morphs in the species. A highly significant genetic...

  7. Multi-objective optimization with estimation of distribution algorithm in a noisy environment.

    Science.gov (United States)

    Shim, Vui Ann; Tan, Kay Chen; Chia, Jun Yong; Al Mamun, Abdullah

    2013-01-01

    Many real-world optimization problems are subjected to uncertainties that may be characterized by the presence of noise in the objective functions. The estimation of distribution algorithm (EDA), which models the global distribution of the population for searching tasks, is one of the evolutionary computation techniques that deals with noisy information. This paper studies the potential of EDAs; particularly an EDA based on restricted Boltzmann machines that handles multi-objective optimization problems in a noisy environment. Noise is introduced to the objective functions in the form of a Gaussian distribution. In order to reduce the detrimental effect of noise, a likelihood correction feature is proposed to tune the marginal probability distribution of each decision variable. The EDA is subsequently hybridized with a particle swarm optimization algorithm in a discrete domain to improve its search ability. The effectiveness of the proposed algorithm is examined via eight benchmark instances with different characteristics and shapes of the Pareto optimal front. The scalability, hybridization, and computational time are rigorously studied. Comparative studies show that the proposed approach outperforms other state of the art algorithms.

  8. Old Wine in New Bottles : Evolutionary Debunking Arguments and the Benacerraf-Field Challenge

    NARCIS (Netherlands)

    Klenk, M.B.O.T.

    2017-01-01

    Evolutionary debunking arguments (EDAs) purport to show that robust moral realism, the metaethical view that there are non-natural and mind-independent moral properties and facts that we can know about, is incompatible with evolutionary explanations of morality. One of the most prominent

  9. Inseguridad, orden y castigo en México : definiciones sobre la fuerza del Estado : una mirada a los discursos públicos. 1994-2006 /

    OpenAIRE

    Oyhandy Cioffi, Angela Graciela sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Ciencias Políticas y Sociales, presenta Angela Graciela Oyhandy Cioffi ; asesor Fernando Castañeda Sabido. 296 páginas. Doctorado en Ciencias Políticas y Sociales UNAM, Facultad de Ciencias Políticas y Sociales, 2009

  10. Food systems brochure - project list Oct 2016 ENGLISH.PUB

    International Development Research Centre (IDRC) Digital Library (Canada)

    fdieudonne

    Examining the link between television and unhealthy eating ... Influence of food packaging on children's energy dense ... Guatemala to encourage healthier beverage choices. (2016–18, Guatemala, Fundación Aldo Castañeda). Reducing dietary-related risks associated with non- ... FOOD MARKETING AND LABELLING.

  11. Adjunct High Frequency Transcutaneous Electric Stimulation (TENS) for Postoperative Pain Management during Weaning from Epidural Analgesia Following Colon Surgery: Results from a Controlled Pilot Study.

    Science.gov (United States)

    Bjerså, Kristofer; Jildenstaal, Pether; Jakobsson, Jan; Egardt, Madelene; Fagevik Olsén, Monika

    2015-12-01

    The potential benefit of nonpharmacological adjunctive therapy is not well-studied following major abdominal surgery. The aim of the present study was to investigate transcutaneous electrical nerve stimulation (TENS) as a complementary nonpharmacological analgesia intervention during weaning from epidural analgesia (EDA) after open lower abdominal surgery. Patients were randomized to TENS and sham TENS during weaning from EDA. The effects on pain at rest, following short walk, and after deep breath were assessed by visual analog scale (VAS) grading. Number of patients assessed was lower than calculated because of change in clinical routine. Pain scores overall were low. A trend of lower pain scores was observed in the active TENS group of patients; a statistical significance between the groups was found for the pain lying prone in bed (p TENS use in postoperative pain management during weaning from EDA after open colon surgery. Further studies are warranted in order to verify the potential beneficial effects from TENS during weaning from EDA after open, lower abdominal surgery. Copyright © 2015 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.

  12. 17. IAEA fusion energy conference. Extended synopses

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-31

    Book of extended synopses of the papers, accepted by a international programme committee for presentation at the 17th IAEA Fusion Energy Conference in Yokohama, Japan. The subjects covered are magnetic confinement experiments, plasma heating and current drive, ITER EDA, inertial fusion energy, innovative concepts, fusion technology and theory Refs, figs, tabs

  13. ITER radio frequency systems

    International Nuclear Information System (INIS)

    Bosia, G.

    1998-01-01

    Neutral Beam Injection and RF heating are two of the methods for heating and current drive in ITER. The three ITER RF systems, which have been developed during the EDA, offer several complementary services and are able to fulfil ITER operational requirements

  14. ¿Dónde vamos con los Entornos Personales de Aprendizaje?

    OpenAIRE

    Attwell, Graham

    2013-01-01

    Para citar: Attwel, G. (2013). ¿Dónde vamos con los Entornos Personales de Aprendizaje? En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 189-192). Alcoy: Marfil.

  15. El PLE de investigación-docencia: el aprendizaje como enseñanza.

    OpenAIRE

    Peña, Ismael

    2013-01-01

    Para citar: Peña, I. (2013). El PLE de investigación-docencia: el aprendizaje como enseñanza. En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 93-110). Alcoy: Marfil.

  16. Enseñanza Flexible y Aprendizaje Abierto, Fundamentos clave de los PLEs

    OpenAIRE

    Salinas Ibáñez, Jesús

    2013-01-01

    Para citar: Salinas, J. (2013). Enseñanza Flexible y Aprendizaje Abierto, Fundamentos clave de los PLEs. En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 53-70). Alcoy: Marfil.

  17. Las pedagogías de los entornos personales de aprendizaje

    OpenAIRE

    Conole, Gráinne

    2013-01-01

    Para citar: Conole, G. (2013). Las pedagogías de los entornos personales de aprendizaje. En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 185-188). Alcoy: Marfil.

  18. Composición y estructura de redes personales en entornos de aprendizaje personales

    OpenAIRE

    Casquero, Oskar

    2013-01-01

    Para citar: Casquero, O. (2013). Composición y estructura de redes personales en entornos de aprendizaje personales. En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 151-160). Alcoy: Marfil.

  19. Genetics Home Reference: anhidrotic ectodermal dysplasia with immune deficiency

    Science.gov (United States)

    ... A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. When EDA-ID is caused by mutations in the NFKBIA gene, the condition is inherited in an autosomal dominant pattern , which means one copy of the altered ...

  20. Entitlement to vote in the Canton of Geneva and entitlement to vote and eligibility for election in the Canton of Vaud

    CERN Multimedia

    DG Unit

    2011-01-01

    You are reminded that, at commune level, certain international civil servants and their family members: are entitled to vote in the Canton of Geneva are entitled to vote and are eligible for election in the Canton of Vaud. For further information, in particular regarding the special procedure to be followed to apply to exercise these entitlements, you are invited to consult the information published, in French only, on the Swiss Mission’s website (topic « Privileges and immunities (Manual) » : http://www.eda.admin.ch/eda/fr/home/topics/intorg/un/unge/gepri/manvot/manvt1.html (for the Canton of Geneva), http://www.eda.admin.ch/eda/fr/home/topics/intorg/un/unge/gepri/manvot/manvt2.html (for the Canton of Vaud). The dates of the forthcoming ballots are available on the official websites of the cantonal administrative authorities : for Geneva: http://www.ge.ch/votations-elections/prochains-scrutins/; for Vaud: http://www.vd.ch/fr/themes/etat-droit-financ...