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Sample records for allergic rhinitis websites

  1. Allergic Rhinitis: Antihistamines

    Science.gov (United States)

    MENU Return to Web version Allergic Rhinitis | Antihistamines What are antihistamines? Antihistamines are medicines that help stop allergy symptoms, such as itchy eyes, sneezing and a runny nose. Sometimes, an antihistamine ...

  2. Allergic rhinitis during pregnancy.

    Science.gov (United States)

    2016-04-01

    During pregnancy, the first-choice drugs for allergic rhinitis are nasal or oral "non-sedating" antihistamines without antimuscarinic activity, in particular cetirizine, or loratadine after the first trimester. PMID:27186624

  3. Sibship Characteristics and Risk of Allergic Rhinitis and Asthma

    DEFF Research Database (Denmark)

    Westergaard, Tine; Rostgaard, Klaus; Wohlfahrt, Jan;

    2005-01-01

    asthma; birth order; hypersensitivity; rhinitis; allergic; perennial; rhinitis; allergic; seasonal; risk factors; siblings......asthma; birth order; hypersensitivity; rhinitis; allergic; perennial; rhinitis; allergic; seasonal; risk factors; siblings...

  4. Rhinitis: Allergic and Non-Allergic

    OpenAIRE

    Ogrady, M.J.

    1987-01-01

    Rhinitis, or the “stuffy nose”, can be allergic or non-allergic in nature. Accurate diagnosis depends on a well-taken history and physical examination. Non-allergic rhinitis is characterized by absent elevation in allergen-specific IgE. Treatment is based, if possible, on the etiology. Surgical procedures on the turbinates are often needed to allow improvement. Allergic rhinitis is characterized by an increase in allergen-specific IgE. Treatment may involve environmental control, pharmocologi...

  5. [Therapy of allergic rhinitis].

    Science.gov (United States)

    Klimek, Ludger; Sperl, Annette

    2016-03-01

    If the avoidance of the provoking allergen is insufficient or not possible, medical treatment can be tried. Therapeutics of the first choice for the treatment of the seasonal and persistent allergic rhinitis are antihistamines and topical glucocorticoids. Chromones are less effective so they should only be used for adults with a special indication, for example during pregnancy. Beside the avoidance of the allergen the immunotherapy is the only causal treatment of allergic diseases. PMID:27120870

  6. Allergic rhinitis: evidence for impact on asthma

    OpenAIRE

    Thomas, Mike

    2006-01-01

    Background This paper reviews the current evidence indicating that comorbid allergic rhinitis may have clinically relevant effects on asthma. Discussion Allergic rhinitis is very common in patients with asthma, with a reported prevalence of up to 100% in those with allergic asthma. While the temporal relation of allergic rhinitis and asthma diagnoses can be variable, the diagnosis of allergic rhinitis often precedes that of asthma. Rhinitis is an independent risk factor for the subsequent dev...

  7. How to Treat Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    孙浩

    2004-01-01

    @@ Characterized by paroxysmal rhinocnesmus and frequent sneezing, allergic rhinitis is often accompanied by itching in the throat and eyes, stuffy nose, anosmia and rhinorrhea, and the condition is aggravated when the patient catches cold.

  8. Pediatric allergic conjunctivitis and allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    Tong Qiao; Yizhen Hu; Zhinan Wang

    2008-01-01

    Objective: To assess the relationship between allergic conjunctivitis(AC) and allergic rhinitis(AR) in pediatric ophthalmology and E.N.T outpatient clinic. Methods:Eight hundred and ninety two patients were enrolled in survey during Mar. 2005~Jan. 2007, 407 allergic conjunctivitis cases were placed in the ophthalmology clinic group and 485 allergic rhinitis cases were from the E.N.T clinic.The comorbid disorders, histories, symptoms, signs of patients were recorded. Type 1 allergy was tested in 479 cases by a specific IgE antibody blood test. Eosinophils were detected in superficial conjunctival scrapings of the superior tarsal conjunctiva and mucosa surface scrapings of middle nasal meatus in 88 cases with both diseases. Results:302(74%), 374(92%), 116(29%) in 407 cases with allergic conjunctivitis had concomitant eczema, rhinitis and asthma, respectively; 334(69%), 430(89%), 145(30%) in 485 cases with allergic rhinitis had concomitant eczema, allergic conjunctivitis and asthma, respectively. The prevalence of allergic conjunctivitis concomitant allergic rhinitis and allergic rhinitis concomitant allergic conjunctivitis had no significant difference(x2=2.6, P>0.05). The prevalence of allergic conjunctivitis and allergic rhinitis concomitant eczema and asthma also had no significant difference (x2=3.08; x2=0.21, P>0.05). The degree of severity of two kinds of disease symptoms is not parallel, in the patients with seasonal allergic conjuctivitis(SAC) and perennial allergic conjunctivitis(PAC), the clinical signs of AR were always severer(x2=258.2, P<0.05)than those of AC. However, the results coincided with the cases with vernal keratoconjuctivitis(VKC)(x2=66.5, P<0.05); Eosinophils were revealed in 50(57%) conjunctival scrapings and nasal mucosa scrapings(x2=1.5, P>0.05), 47(53%) cases had positive results in both scrapings. The main aeroallergens were house dust mites, house dust and fungi, and the main food-allergens were fish, crab and shrimp

  9. Allergic Rhinitis in Childhood - Review

    Directory of Open Access Journals (Sweden)

    Arzu Babayiğit

    2010-12-01

    Full Text Available Allergic rhinitis, an immunoglobulin E mediated disease, is the most common chronic allergic childhood disease. The disease is characterized by nasal sneezing, rhinorrhea, palate and eye itchiness, and congestion and it can significantly impact children’s health. It causes uncomfortable symptoms, impairs quality of life and can predispose to the development of comorbidities such as asthma. Etiological diagnosis is based on cutaneous prick tests, which have a high sensitivity and specificity rate and which can be easily applied to young children. Treatment initially involves avoidance measures and, when necessary, pharmacotherapy or immunotherapy. Pharmacotherapy generally involves antihistamines and/or nasal corticosteroids, but leukotriene antagonists have also demonstrated effectiveness in treating allergic rhinitis symptoms. In this article, the symptoms, diagnosis and treatment of allergic rhinitis in childhood are discussed. (Journal of Current Pediatrics 2010; 8: 105-12

  10. Allergic Rhinitis: Mechanisms and Treatment.

    Science.gov (United States)

    Bernstein, David I; Schwartz, Gene; Bernstein, Jonathan A

    2016-05-01

    The prevalence of allergic rhinitis (AR) has been estimated at 10% to 40%, and its economic burden is substantial. AR patients develop specific immunoglobulin E (IgE) antibody responses to indoor and outdoor environmental allergens with exposure over time. These specific IgE antibodies bind to high-affinity IgE receptors on mast cells and basophils. Key outcome measures of therapeutic interventions include rhinitis symptom control, rescue medication requirements, and quality-of-life measures. A comprehensive multiple modality treatment plan customized to the individual patient can optimize outcomes. PMID:27083101

  11. Remission of allergic rhinitis

    DEFF Research Database (Denmark)

    Bødtger, Uffe; Linneberg, Allan

    2004-01-01

    months and s-IgE levels of class 2 or greater against pollen (birch, grass, or mugwort). This was similar for AR to animals (cat or dog) or house dust mites (HDMs). Remission of AR was defined as AR at baseline but no rhinitis symptoms at follow-up and sensitization (s-IgE level class > or =2 at baseline...

  12. Alternaria in Patients with Allergic Rhinitis

    OpenAIRE

    Monireh Mokhtari Amirmajdi; Nemat Allah Mokhtari Amirmajdi; Iman Eftekharzadeh Mashhadi; Farahzad Jabari Azad; Jalil Tavakol Afshari; Mohammad-Taghi Shakeri

    2011-01-01

    Inhalation of fungal spores is shown to participate in the development of allergic rhinitis symptoms. In this study, relation between presence of Alternaria in the human nasal cavity and allergic rhinitis is assessed.In a case-control study, 58 allergic rhinitis patients were compared with a well-matched control group of fifty healthy volunteers for sensitization to Alternaria (by skin prick test) and detection of Alternaria in their nasal mucous by conventional methods (microscopy with Methy...

  13. Optimal management of allergic rhinitis

    OpenAIRE

    Scadding, G K

    2015-01-01

    Allergic rhinitis (AR), the most common chronic disease in childhood is often ignored, misdiagnosed and/or mistreated. Undertreated AR impairs quality of life, exacerbates asthma and is a major factor in asthma development. It can involve the nose itself, as well as the organs connected with the nose manifesting a variety of symptoms. Evidence-based guidelines for AR therapy improve disease control. Recently, paediatric AR guidelines have been published by the European Academy of Allergy and ...

  14. Current management of allergic rhinitis in children

    NARCIS (Netherlands)

    C. Georgalas; I. Terreehorst; W. Fokkens

    2010-01-01

    Over the last 20 years, there has been significant progress in our understanding of the pathophysiology of allergic rhinitis, including the discovery of new inflammatory mediators, the link between asthma and allergic rhinitis ('one airway-one disease' concept) and the introduction of novel therapeu

  15. Treating allergic rhinitis in pregnancy.

    Science.gov (United States)

    Piette, Vincent; Daures, Jean-Pierre; Demoly, Pascal

    2006-05-01

    Numerous pregnant women suffer from allergic rhinitis, and particular attention is required when prescribing drugs to these patients. In addition, physiologic changes associated with pregnancy could affect the upper airways. Evidence-based guidelines on the management of allergic rhinitis have been published. Medication can be prescribed during pregnancy when the apparent benefit of the drug is greater than the apparent risk. Usually, there is at least one "safe" drug from each major class used to control symptoms. All glucocorticosteroids are teratogenic in animals but, when the indication is clear (for diseases possibly associated, such as severe asthma exacerbation), the benefit of the drug is far greater than the risk. Inhaled glucocorticosteroids (eg, beclomethasone or budesonide) have not been incriminated as teratogens in humans and are used by pregnant women who have asthma. A few H1-antihistamines can safely be used as well. Most oral decongestants (except pseudoephedrine) are teratogenic in animals. There are no such data available for intranasal decongestants. Finally, pregnancy is not considered to be a contraindication for the continuation of immunotherapy.

  16. [Definition and clinic of the allergic rhinitis].

    Science.gov (United States)

    Spielhaupter, Magdalena

    2016-03-01

    The allergic rhinitis is the most common immune disorder with a lifetime prevalence of 24% and one of the most common chronic diseases at all--with tendency to rise. It occurs in childhood and influences the patients' social life, school performance and labour productivity. Furthermore the allergic rhinitis is accompanied by a lot of comorbidities, including conjunctivitis, asthma bronchiale, food allergy, neurodermatitis and sinusitis. For example the risk for asthma is 3.2-fold higher for adults with allergic rhinitis than for healthy people.

  17. Assessment of disease control in allergic rhinitis.

    OpenAIRE

    Demoly, Pascal; Calderon, Moises; Casale, Thomas; Scadding, Glenis; Annesi-Maesano, Isabella; Braun, Jean-Jacques; Delaisi, Bertrand; Haddad, Thierry; Malard, Olivier; Trébuchon, Florence; Serrano, Elie

    2013-01-01

    International audience The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative has had a significant impact, by raising awareness of allergic rhinitis (AR) and improving the diagnosis and treatment of AR sufferers. ARIA classifies the severity of AR as "mild" or "moderate/severe" on the basis of "yes"/"no" answers to four questions. This two-point classification has been criticized as providing little guidance on patient management; patients with "mild" AR are unlikely to consult ...

  18. Heart Rate Variability Analysis in Patients with Allergic Rhinitis

    OpenAIRE

    Ming-Ying Lan; Guo-She Lee; An-Suey Shiao; Jen-Hung Ko; Chih-Hung Shu

    2013-01-01

    Background. Very few studies investigate the role of the autonomic nervous system in allergic rhinitis. In this study, we evaluated the autonomic nervous system in allergic rhinitis patients using heart rate variability (HRV) analysis. Methods. Eleven patients with allergic rhinitis and 13 healthy controls, aged between 19 and 40 years old, were enrolled in the study. Diagnosis of allergic rhinitis was based on clinical history, symptoms, and positive Phadiatop test. Electrocardiographic reco...

  19. Alternaria in Patients with Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Monireh Mokhtari Amirmajdi

    2011-09-01

    Full Text Available Inhalation of fungal spores is shown to participate in the development of allergic rhinitis symptoms. In this study, relation between presence of Alternaria in the human nasal cavity and allergic rhinitis is assessed.In a case-control study, 58 allergic rhinitis patients were compared with a well-matched control group of fifty healthy volunteers for sensitization to Alternaria (by skin prick test and detection of Alternaria in their nasal mucous by conventional methods (microscopy with Methylene Blue stain and culture in Sabourad dextrose agar. Severity of the disease was determined according to  the ARIA classification. Pearson chi-square test was applied to compare the proportional difference between the study groups for detection of Alternaria in the nasal cavity, and sensitization to Alternaria.Relation between detection of Alternaria and allergic rhinitis was significant [OR = 18.18 (4.02-82.50] In addition, sensitization to Alternaria showed a significant relation with the disease [OR  =  2.8 (2.1-3.8]. There  was a significant relation between the  presence  of Alternaria in the nasal cavity and sensitization to Alternaria [OR =  10.4 (3.8-28.3]. Both sensitization to  Alternaria and presence of Alternaria in the nasal cavity did not  have a significant relation with the severity of allergic rhinitis. This study suggests Alternaria as a major  allergen that  its  presence  in  the  nasal  cavity and  subsequent  development  of sensitization have significant role in the induction of allergic rhinitis.

  20. Nasal hyperreactivity and inflammation in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    I. M. Garrelds

    1996-01-01

    Full Text Available The history of allergic disease goes back to 1819, when Bostock described his own ‘periodical affection of the eyes and chest’, which he called ‘summer catarrh’. Since they thought it was produced by the effluvium of new hay, this condition was also called hay fever. Later, in 1873, Blackley established that pollen played an important role in the causation of hay fever. Nowadays, the definition of allergy is ‘An untoward physiologic event mediated by a variety of different immunologic reactions’. In this review, the term allergy will be restricted to the IgE-dependent reactions. The most important clinical manifestations of IgE-dependent reactions are allergic conjunctivitis, allergic rhinitis, allergic asthma and atopic dermatitis. However, this review will be restricted to allergic rhinitis. The histopathological features of allergic inflammation involve an increase in blood flow and vascular permeability, leading to plasma exudation and the formation of oedema. In addition, a cascade of events occurs which involves a variety of inflammatory cells. These inflammatory cells migrate under the influence of chemotactic agents to the site of injury and induce the process of repair. Several types of inflammatory cells have been implicated in the pathogenesis of allergic rhinitis. After specific or nonspecific stimuli, inflammatory mediators are generated from cells normally found in the nose, such as mast cells, antigen-presenting cells and epithelial cells (primary effector cells and from cells recruited into the nose, such as basophils, eosinophils, lymphocytes, platelets and neutrophils (secondary effector cells. This review describes the identification of each of the inflammatory cells and their mediators which play a role in the perennial allergic processes in the nose of rhinitis patients.

  1. Links between allergic rhinitis and asthma

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Allergic diseases of the airway, which include seasonal rhinitis, chronic perennial rhinitis and asthma, are recognized as inflammatory disorders of the airway mucosa,1-3 but differ in the location of the inflammatory reaction and clinical manifestations of the disease. Asthma and allergic rhinitis frequently coexist in the same patient and are thought to share common predisposing genetic factors which interact with the environmental influences. Both diseases have increased in prevalence over recent decades4,5 particularly in westernized countries. This increase has been largely attributed to environmental factors such as exposure to aerial pollutants,4,6 and early life events, including the degree of exposure to infectious agents which might affect IgE production,5,7 since there has been insufficient time for a significant change in the gene pool.

  2. Steroids vs immunotherapy for allergic rhinitis

    DEFF Research Database (Denmark)

    Aasbjerg, Kristian; Backer, Vibeke

    2014-01-01

    Treatment for seasonal allergic rhinitis induced by airborne allergens can be divided into two major groups: symptom-dampening drugs, such as antihistamines and corticosteroids, and disease-modifying drugs in the form of immunotherapy. It has been speculated that depot-injection corticosteroids g...

  3. Treatment of allergic rhinitis during pregnancy.

    Science.gov (United States)

    Demoly, Pascal; Piette, Vincent; Daures, Jean-Pierre

    2003-01-01

    Allergic rhinitis is a frequent problem during pregnancy. In addition, physiological changes associated with pregnancy can affect the upper airways. Evidence-based guidelines on the management of allergic rhinitis have recently been published, the most recent being the Allergic Rhinitis and its Impact on Asthma (ARIA)--World Health Organization consensus. Many pregnant women experience allergic rhinitis and particular attention is required when prescribing drugs to these patients. Medication can be prescribed during pregnancy when the apparent benefit of the drug is greater than the apparent risk. Usually, there is at least one drug from each major class that can be safely utilised to control symptoms. All glucocorticosteroids are teratogenic in animals but, when the indication is clear (for diseases possibly associated, such as severe asthma exacerbation), the benefit of the drug is far greater than the risk. Inhaled glucocorticosteroids (e.g. beclomethasone or budesonide) have not been incriminated as teratogens in humans and are used by pregnant women who have asthma. A few histamine H(1)-receptor antagonists (H(1)-antihistamines) can safely be used as well. Most oral decongestants (except pseudoephedrine) are teratogenic in animals. There are no such data available for intra-nasal decongestants. Finally, pregnancy is not considered as a contraindication for the continuation of allergen specific immunotherapy.

  4. When perennial rhinitis worsens: rhinolith mimicking severe allergic rhinitis

    Science.gov (United States)

    Heffler, Enrico; Machetta, Giacomo; Magnano, Mauro; Rolla, Giovanni

    2014-01-01

    Allergic rhinitis is one of the most common causes of nasal obstruction, but other diseases need to be considered particularly when the clinical course is getting worse. We present a patient with known mild persistent allergic rhinitis due to house dust mites who experienced progressive worsening of nasal obstruction with associated hyposmia and mucopurulent discharge. The lack of improvement of the patient’s symptoms prompted the re-evaluation of the case. Skin prick tests for airborne allergens confirmed sensitisation only to house dust mites. Nasal endoscopy and facial CT scan revealed a huge rhinolith occupying almost completely the right nasal cavity. The rhinolith was surgically removed with resolution of symptoms. Rhinoliths are rare and unusual calcified materials which grow around intranasal foreign body; they are often promoted by trauma, surgical operations and dental work. The patient underwent dental work about 30 months before the diagnosis of rhinolith, suggesting a possible aetiology. PMID:24526202

  5. Moxibustion with Chinese herbal has good effect on allergic rhinitis

    OpenAIRE

    Min, Cunyun; Peng, Congjian; Wei, Guojian; Huang, Xuhui; Fu, Tingting; Du, Yu; Wang, Changjun

    2015-01-01

    Allergic rhinitis (AR) is a chronic inflammatory disease of rhino-ocular mucosa, affecting up to 40% of population worldwide. Chinese herbal medicines and Acupuncture, adopted thousands of years in China, has good effect on allergic rhinitis. This study evaluates the effects of Moxibustion with Chinese herbal in treating patients with allergic rhinitis over a 1-year follow-up. A randomized controlled trial was conducted in a sample of 355 participants recruited from Guangdong general hospital...

  6. Epidemiologic studies of the risk factors of allergic rhinitis

    OpenAIRE

    Saulyte, Jurgita

    2016-01-01

    This work consists of two parts, with the aim to identify modifiable, lifestylerelated risk factors, such as smoking and diet habits, of allergic rhinitis. Part one is a systematic review and meta-analysis on active and passive exposure to tobacco smoking and allergic rhinitis. The objective of this metaanalysis was to examine the evidence for an association between active smoking and passive exposure to secondhand smoke and allergic rhinitis in children and adults. The resu...

  7. Role of Cysteinyl Leukotrienes in Allergic Rhinitis.

    Science.gov (United States)

    Shirasaki, Hideaki; Himi, Tetsuo

    2016-01-01

    Cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. Pharmacological studies using CysLTs indicate that two classes of receptor exist: CysLT1 receptor (CysLT1R) and CysLT2 receptor (CysLT2R). The CysLT1R is a high-affinity leukotriene D4 receptor with lower affinity for leukotriene C4 that is sensitive to the CysLT1R antagonist currently used to treat asthma and allergic rhinitis. Our previous immunohistochemical and autoradiographic studies have demonstrated the presence of anti-CysLT1R antibodies labeled in eosinophils, mast cells, macrophages, neutrophils and vascular endothelial cells in human nasal mucosa. Furthermore, we have revealed that the novel radioactive CysLT1R antagonist [3H]-pranlukast bound specifically to CysLT1R in human inferior turbinates and its binding sites were localized to vascular endothelium and the interstitial cells. These data suggest that the major targets of CysLT1R antagonists in allergic rhinitis are the vascular bed and infiltrated leukocytes such as mast cells, eosinophils and macrophages. Clinical trials have demonstrated that CysLT1R antagonists are as effective as antihistamines for the treatment of allergic rhinitis; however, they are less effective than intranasal steroids. The use of CysLT1R antagonists in combination with antihistamines has generally resulted in greater efficacy than when these agents were used alone. PMID:27115997

  8. Benzaldehyde suppresses murine allergic asthma and rhinitis.

    Science.gov (United States)

    Jang, Tae Young; Park, Chang-Shin; Kim, Kyu-Sung; Heo, Min-Jeong; Kim, Young Hyo

    2014-10-01

    To evaluate the antiallergic effects of oral benzaldehyde in a murine model of allergic asthma and rhinitis, we divided 20 female BALB/c mice aged 8-10 weeks into nonallergic (intraperitoneally sensitized and intranasally challenged to normal saline), allergic (intraperitoneally sensitized and intranasally challenged to ovalbumin), and 200- and 400-mg/kg benzaldehyde (allergic but treated) groups. The number of nose-scratching events in 10 min, levels of total and ovalbumin-specific IgE in serum, differential counts of inflammatory cells in bronchoalveolar lavage (BAL) fluid, titers of Th2 cytokines (IL-4, IL-5, IL-13) in BAL fluid, histopathologic findings of lung and nasal tissues, and expressions of proteins involved in apoptosis (Bcl-2, Bax, caspase-3), inflammation (COX-2), antioxidation (extracellular SOD, HO-1), and hypoxia (HIF-1α, VEGF) in lung tissue were evaluated. The treated mice had significantly fewer nose-scratching events, less inflammatory cell infiltration in lung and nasal tissues, and lower HIF-1α and VEGF expressions in lung tissue than the allergic group. The number of eosinophils and neutrophils and Th2 cytokine titers in BAL fluid significantly decreased after the treatment (Pbenzaldehyde exerts antiallergic effects in murine allergic asthma and rhinitis, possibly through inhibition of HIF-1α and VEGF.

  9. The Quality of Health Information on Allergic Rhinitis, Rhinitis, and Sinusitis Available on the Internet

    OpenAIRE

    Chang, Mun Young; Kim, Jeong-Whun; Rhee, Chae-Seo

    2014-01-01

    Purpose The internet has become one of the most important media outlets used to obtain health information. Therefore, the quality of health information available on the internet is very important. We evaluated the quality of internet-derived health information on allergic rhinitis, rhinitis and sinusitis and compared these results to those of previous studies performed five years ago. Methods The terms "allergic rhinitis (AR)", "rhinitis" and "sinusitis" were searched among the four most comm...

  10. Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history.

    Science.gov (United States)

    Gelardi, M; Iannuzzi, L; Tafuri, S; Passalacqua, G; Quaranta, N

    2014-02-01

    Rhinitis and rhinosinusitis (with/without polyposis), either allergic or non-allergic, represent a major medical problem. Their associated comorbidities and relationship with family history have so far been poorly investigated. We assessed these aspects in a large population of patients suffering from rhinosinusal diseases. Clinical history, nasal cytology, allergy testing and direct nasal examination were performed in all patients referred for rhinitis/rhinosinusitis. Fibre optic nasal endoscopy, CT scan and nasal challenge were used for diagnosis, when indicated. A total of 455 patients (60.7% male, age range 4-84 years) were studied; 108 (23.7%) had allergic rhinitis, 128 (28.1%) rhinosinusitis with polyposis, 107 (23.5%) non-allergic rhinitis (negative skin test); 112 patients had associated allergic and non-allergic rhinitis, the majority with eosinophilia. There was a significant association between non-allergic rhinitis and family history of nasal polyposis (OR = 4.45; 95%CI = 1.70-11.61; p = 0.0019), whereas this association was no longer present when allergic rhinitis was also included. Asthma was equally frequent in non-allergic and allergic rhinitis, but more frequent in patients with polyposis. Aspirin sensitivity was more frequent in nasal polyposis, independent of the allergic (p = 0.03) or non-allergic (p = 0.01) nature of rhinitis. Nasal polyposis is significantly associated with asthma and positive family history of asthma, partially independent of the allergic aetiology of rhinitis.

  11. Expression of Pendrin Periostin in Allergic Rhinitis Chronic Rhinosinusitis

    Directory of Open Access Journals (Sweden)

    Akihiro Ishida

    2012-01-01

    Conclusions: : Production of pendrin and periostin is upregulated in allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin-induced asthma. These findings suggest that pendrin can induce mucus production and that periostin can induce tissue fibrosis and remodeling in the nasal mucosa. Therefore, these mediators may be therapeutic target candidates for allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin- induced asthma.

  12. STUDY OF PREVALENCE OF EOSINOPHILIA IN ALLERGIC RHINITIS

    Directory of Open Access Journals (Sweden)

    Ravi Kumar

    2015-10-01

    Full Text Available BACKGROUND: Allergic rhinitis is a common condition, though not life threatening, causes significant morbidity in terms of quality of life. Confirmation of allergen as etiological agent is cumbersome. Hence need for a simple test is vital and eosinophil parameters were looked at to answer the quest. AIM: To find out the prevalence of e osinophilia in Allergic rhinitis . To assess the value of nasal cytogram as an alternative investigation in diagnosing allergic rhinitis . MATERIALS & METHODS: Prospective study of 200 cases divided into two groups of 100 each was done. One group clinically with allergic rhinitis and other without. All cases had clinical examination after history was taken, Blood Absolute eosinophil count, Nasal smear for eosinophils done and assessed. RESULTS: Of the 200 patients examined in two groups of 100 each, mean age of allergic rhinitis patients was 26.22 years . Allergic rhinitis was more common in males than females. Prevalence of nasal eosinophilia was 61%.and blood eosinophilia was 57% in allergic rhinitis patients. Nasal smear sensitivity was 61% and specificity w as 87% . CONCLUSION: Nasal smear eosinophilia is a valid test, can be quickly and easily performed and read. Being an in - expensive test can be used to screen the patients of allergic rhinitis

  13. Allergic Rhinitis and its Impact on Asthma (ARIA)

    DEFF Research Database (Denmark)

    Bousquet, J; Schünemann, H J; Samolinski, B;

    2012-01-01

    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has rec...... workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children....

  14. Is Allergic Rhinitis a Factor That Affects Success of Tympanoplasty?

    Directory of Open Access Journals (Sweden)

    Elif Ersoy Callioglu

    2016-04-01

    Full Text Available Objective: The aim of the present study was to investigate the effect of allergic rhinitis on the success of the operation in chronic otitis surgery by using score for allergic rhinitis (SFAR. Materials and Methods: In the present study; 121 patients, who underwent type 1 tympanoplasty were examined retrospectively. SFAR of all patients were recorded. The graft success rates of 26 patients with allergic rhinitis (AR and 95 patients with no allergic rhinitis group (NAR were compared. Results: While the graft success rate in NAR group was 89.5%, this rate was 80.8% in the AR group. However, the difference between groups was not statistically significant (p = 0.311. Conclusion: These findings suggest that allergic rhinitis decreases the graft success rate of the pathologies occurring in eustachian tube, middle ear and mastoid although statistically significant difference wasn’t found. Prospective studies with larger patient groups are required in order to evaluate this pathology.

  15. Number of siblings and allergic rhinitis in children

    Directory of Open Access Journals (Sweden)

    Soewira Sastra

    2016-05-01

    Full Text Available Background Allergic rhinitis is one of the most common chronic diseases of childhood. Recent studies have suggested that having fewer siblings was associated with allergic rhinitis and atopic diseases in children. Previous studies also indicated that older siblings was associated with higher incidence of allergic rhinitis.Objectives To assess for a possible association between number of siblings and allergic rhinitis and to assess for an effect of birth order on allergic rhinitis in children.Methods We performed a cross-sectional study among school children aged 7 to 15 years, in the West Medan District from July to August 2011. Children with moderate or high risk of allergy were included. Subjects were divided into two groups, those with <3 siblings or ≥3 siblings. Children with acute respiratory tract infections, septal deviation, choanal atresia, nasal polyps, nasal tumors, or nasal foreign body were excluded. Risk of allergy was determined using the Indonesian Pediatrics Allergy Immunology Working Group trace card scoring system. Identification of allergic rhinitis and evaluation of its severity were done by use of the International Study of Asthma and Allergies in Childhood (ISAAC core questionnaire. Allergic rhinitis was diagnosed based on history, physical examination, and anterior rhinoscopy.Results A total of 78 subjects were enrolled. Allergic rhinitis was significantly higher in children with <3 siblings than those with ≥3 siblings (OR 10.33; 95%CI 3.569 to 29.916. Furthermore, allergic rhinitis was significantly higher in first-born children than in their younger siblings (P=0.0001.Conclusion Larger number of siblings and non-first-born children are associated with lower incidence of allergic rhinitis in children.

  16. Number of siblings and allergic rhinitis in children

    Directory of Open Access Journals (Sweden)

    Soewira Sastra

    2016-01-01

    Full Text Available Background Allergic rhinitis is one of the most common chronic diseases of childhood. Recent studies have suggested that having fewer siblings was associated with allergic rhinitis and atopic diseases in children. Previous studies also indicated that older siblings was associated with higher incidence of allergic rhinitis. Objectives To assess for a possible association between number of siblings and allergic rhinitis and to assess for an effect of birth order on allergic rhinitis in children. Methods We performed a cross-sectional study among school children aged 7 to 15 years, in the West Medan District from July to August 2011. Children with moderate or high risk of allergy were included. Subjects were divided into two groups, those with <3 siblings or ≥3 siblings. Children with acute respiratory tract infections, septal deviation, choanal atresia, nasal polyps, nasal tumors, or nasal foreign body were excluded. Risk of allergy was determined using the Indonesian Pediatrics Allergy Immunology Working Group trace card scoring system. Identification of aller-allergic rhinitis and evaluation of its severity were done by use of the International Study of Asthma and Allergies in Childhood (ISAAC core questionnaire. Allergic rhinitis was diagnosed based on history, physical examination, and anterior rhinoscopy. Results A total of 78 subjects were enrolled. Allergic rhinitis was significantly higher in children with <3 siblings than those with ≥3 siblings (OR 10.33; 95%CI 3.569 to 29.916. Furthermore, allergic rhinitis was significantly higher in first-born children than in their younger siblings (P=0.0001. Conclusion Larger number of siblings and non-first-born children are associated with lower incidence of allergic rhinitis in children.

  17. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis

    DEFF Research Database (Denmark)

    Chawes, Bo Lk

    2011-01-01

    nasal eosinophilia albeit less than children with allergic rhinitis. These findings suggest different pathology in allergic- and non-allergic rhinitis which may have important clinical implications for early pharmacological treatment of rhinitis in young children. In paper II, we utilized the nasal...... with allergic rhinitis without asthma suggesting sub-clinical bronchial inflammation and supporting the allergic disease process to involve both upper and lower airways. In conclusion, these observations objectively show marked differences in nasal pathology in young children with allergic- and non...... resources. Unfortunately, diagnostic specificity is hampered by nonspecific symptom history and lack of reliable diagnostic tests which may explain why the pathology behind such diagnoses is poorly understood. Improved understanding of the pathophysiology of allergic- and non-allergic rhinitis in young...

  18. Neurology of allergic inflammation and rhinitis.

    Science.gov (United States)

    Canning, Brendan J

    2002-05-01

    Afferent nerves, derived from the trigeminal ganglion, and postganglionic autonomic nerves, derived from sympathetic and parasympathetic ganglia expressing many different neurotransmitters, innervate the nose. Reflexes that serve to optimize the air-conditioning function of the nose by altering sinus blood flow, or serve to protect the nasal mucosal surface by mucus secretion, vasodilatation, and sneezing, can be initiated by a variety of stimuli, including allergen, cold air, and chemical irritation. Activation of nasal afferent nerves can also have profound effects on respiration, heart rate, blood pressure, and airway caliber (the diving response). Dysregulation of the nerves in the nose plays an integral role in the pathogenesis of allergic rhinitis. Axon reflexes can precipitate inflammatory responses in the nose, resulting in plasma extravasation and inflammatory cell recruitment, while allergic inflammation can produce neuronal hyper-responsiveness. Targeting the neuronal dysregulation in the nose may be beneficial in treating upper airway disease. PMID:11918862

  19. Treatment of Allergic Rhinitis Is Associated with Improved Attention Performance in Children: The Allergic Rhinitis Cohort Study for Kids (ARCO-Kids)

    OpenAIRE

    Dong-Kyu Kim; Chae Seo Rhee; Doo Hee Han; Tae-Bin Won; Dong-Young Kim; Jeong-Whun Kim

    2014-01-01

    BACKGROUND: It has been well known that pediatric allergic rhinitis was associated with poor performance at school due to attention deficit. However, there were no cohort studies for the effect of treatment of allergic rhinitis on attention performance in pediatric population. Thus, the aim of this study was to investigate whether attention performance was improved after treatment in children with allergic rhinitis. METHODS: In this ARCO-Kids (Allergic Rhinitis Cohort Study for Kids), consecu...

  20. Assessment of disease control in allergic rhinitis.

    Science.gov (United States)

    Demoly, Pascal; Calderon, Moises A; Casale, Thomas; Scadding, Glenis; Annesi-Maesano, Isabella; Braun, Jean-Jacques; Delaisi, Bertrand; Haddad, Thierry; Malard, Olivier; Trébuchon, Florence; Serrano, Elie

    2013-01-01

    The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative has had a significant impact, by raising awareness of allergic rhinitis (AR) and improving the diagnosis and treatment of AR sufferers. ARIA classifies the severity of AR as "mild" or "moderate/severe" on the basis of "yes"/"no" answers to four questions. This two-point classification has been criticized as providing little guidance on patient management; patients with "mild" AR are unlikely to consult a physician, whereas the group of patients with "moderate/severe" seen by specialists is heterogeneous. These perceived shortcomings have prompted attempts to improve the ARIA classification or, by analogy with the Global Initiative for Asthma (GINA), adopt approaches based on "disease control" in AR. Even though "disease severity", "disease control" and "responsiveness to treatment" are different (albeit related) metrics, they are not mutually exclusive. Currently, there is no single, accepted definition, but we propose that "disease control" in AR can combine (i) measurements of the severity and/or frequency of daily or nocturnal symptoms, (ii) impairments in social, physical, professional and educational activities, (iii) respiratory function monitoring and (iv) exacerbations (e.g. unscheduled medical consultations and rescue medication use). Although control-based classifications have a number of limitations (e.g. their dependence on treatment compliance and the patient's psychological status), these instruments could be used as an adjunct to the ARIA severity classification and regional practice parameters. Here, we assess the strengths and weaknesses of the current two-level ARIA classification, analyze published proposals for its modification and review the literature on instruments that measure AR control. We conclude that there is a need for research in which severity is compared with control in terms of their effects on patient management. PMID:23419058

  1. Allergic rhinitis - what to ask your doctor - child

    Science.gov (United States)

    ... How do I find out when smog or pollution is worse in our area? What does my ... More Allergen Allergic rhinitis Allergies - overview Allergy testing - skin Asthma and allergy - resources Common cold Sneezing Patient ...

  2. Allergic rhinitis - what to ask your doctor - adult

    Science.gov (United States)

    ... How do I find out when smog or pollution is worse in my area? Am I taking ... More Allergen Allergic rhinitis Allergies - overview Allergy testing - skin Asthma and allergy - resources Common cold Sneezing Patient ...

  3. Efficacy of montelukast and desloratadine combination in allergic rhinitis

    OpenAIRE

    Cingi, Cemal; Oğhan, Fatih; Ünlü, Halis; Tekat, Atilla; Okuyucu, Şemsettin

    2011-01-01

    Allergic rhinitis represents a global health problem affecting 10 to 25% of the population worldwide. The complications i.e. sinusitis, nasal polyps, middle ear and lower respiratory tract infections increase the importance of allergic rhinitis. Besides treatment costs, due to wage loss and decrease in productive capacity it has a huge negative impact on community. It may also seriously affect quality of life. Despite recent developments in its treatment modalities, several studies have indic...

  4. Heart Rate Variability Analysis in Patients with Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Ming-Ying Lan

    2013-01-01

    Full Text Available Background. Very few studies investigate the role of the autonomic nervous system in allergic rhinitis. In this study, we evaluated the autonomic nervous system in allergic rhinitis patients using heart rate variability (HRV analysis. Methods. Eleven patients with allergic rhinitis and 13 healthy controls, aged between 19 and 40 years old, were enrolled in the study. Diagnosis of allergic rhinitis was based on clinical history, symptoms, and positive Phadiatop test. Electrocardiographic recordings on the sitting and supine positions were obtained for HRV analysis. Results. In the supine position, there were no significant statistical differences in very-low-frequency power (VLF, ≤0.04 Hz, low-frequency power (LF, 0.04–0.15 Hz, high-frequency power (HF, 0.15–0.40 Hz, and the ratio of LF to HF (LF/HF between the patient and control groups. The mean RR intervals significantly increased, while LF% and LF/HF significantly decreased in the patient group in the sitting position. Moreover, mean RR intervals, LF, and LF/HF, which were significantly different between the two positions in the control group, did not show a significant change with the posture change in the patient group. Conclusion. These suggest that patients with allergic rhinitis may have poor sympathetic modulation in the sitting position. Autonomic dysfunction may therefore play a role in the pathophysiology of allergic rhinitis.

  5. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis)

    DEFF Research Database (Denmark)

    Bousquet, J; Schunemann, H J; Fonseca, J;

    2015-01-01

    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patien...

  6. Vitamin D serum levels in allergic rhinitis: any difference from normal population?

    OpenAIRE

    Arshi, Saba; Ghalehbaghi, Babak; Kamrava, Seyyed-Kamran; Aminlou, Mina

    2012-01-01

    Background Recently it has been suggested that, the worldwide increase in allergic diseases such as asthma, allergic rhinitis and food allergy is associated with low vitamin D intake. Objective This study measured the vitamin D levels in patients with allergic rhinitis and compared the results with the general population. Methods Vitamin D levels were assessed in 50 patients with allergic rhinitis diagnosed clinically by Allergic Rhinitis and its Impact on Asthma 2008 criteria and the result ...

  7. 553 Correlation between Severity of Allergic Rhinitis and Impairment of Quality of Life in Allergic Adolescents

    OpenAIRE

    Infante, Eric Martinez

    2012-01-01

    Background Determine severity of the disease and its correlation with the degree of impairment in quality of life in adolescent patients with allergic rhinitis. Methods Were captured 124 adolescents aged 10 to 17 years, attending the outpatient Allergy Service at Social Security Hospital in Mexico, diagnosed with Allergic Rhinitis (AR). Before the clinical evaluation to confirm the diagnosis, severity of Allergic Rhinitis were classified according to criteria of Allergic Rhinitis and its Impa...

  8. Treatment of 67 Cases of Seasonal Allergic Rhinitis by Acupuncture

    Institute of Scientific and Technical Information of China (English)

    王旭; 张利; 王鹰雷; 黄国琪

    2010-01-01

    @@ Seasonal allergic rhinitis refers to a seasonal and regional allergic disease induced mainly by botanical pollen,also termed "Hay Fever" and "Pollinosis",clinically manifested by the main symptoms of itching sensation in the nose,nasal obstruction,sneezing,watery nasal discharge,conjunctival congestion,itching in the eyes,lacrimation,and asthma developed from an incessant cough in some people,or manifested by the gastrointestinal symptoms of nausea,vomiting,abdominal pain,and diarrhea,and skin eczema,urticaria,pruritus vulvae,vaginitis.The author treated 67 cases of seasonal allergic rhinitis by acupuncture from 2002 to 2004.Now,the result is summarized as follows.

  9. Olfaction in allergic rhinitis: A systematic review.

    Science.gov (United States)

    Stuck, Boris A; Hummel, Thomas

    2015-12-01

    Olfactory dysfunction is a key symptom in patients with allergic rhinitis (AR). Despite the implications for quality of life, relatively few articles have tested olfactory function in their investigations. The current systematic review aimed to investigate the following 2 questions: (1) What does AR do to human olfaction? (2) How effective is the treatment of AR in restoring the sense of smell? A comprehensive literature search was performed, and human studies of any design were included. A total of 420 articles were identified, and 36 articles were considered relevant. Data indicate that the frequency of olfactory dysfunction increases with the duration of the disorder, and most studies report a frequency in the range of 20% to 40%. Although olfactory dysfunction does not appear to be very severe in patients with AR, its presence seems to increase with the severity of the disease. There is very limited evidence that antihistamines improve olfactory function. In addition, there is limited evidence that topical steroids improve the sense of smell, especially in patients with seasonal AR. This is also the case for specific immunotherapy. However, many questions remain unanswered because randomized controlled trials are infrequent and only a few studies rely on quantitative measurement of olfactory function.

  10. Local allergic rhinitis: A critical reappraisal from a paediatric perspective.

    Science.gov (United States)

    Arasi, Stefania; Pajno, Giovanni Battista; Lau, Susanne; Matricardi, Paolo Maria

    2016-09-01

    The so-called local allergic rhinitis (LAR) has been proposed as a phenotype of rhinitis with Th2-driven prominent local allergic inflammation, nasal synthesis of specific IgE and a positive response to a nasal allergen provocation test, in the absence of 'systemic' atopy (negative skin prick test and serum allergen-specific IgE antibodies). To date, available data on LAR are mostly focused on adults. The purpose of this 'Rostrum' was to critically discuss data and implications of the 'LAR concept' in paediatrics. In the natural history of rhinitis due to IgE-mediated reactions triggered by exposure to allergens, a 'LAR' can be either the initial, transient stage of classical allergic rhinitis or a stable phenotype never evolving to 'systemic' IgE sensitization. Given the present difficulties in performing routinely nasal allergen provocation test in children, the development of sensitive and specific tests to detect IgE in the child's nasal secretions is a research priority. We suggest also the hypothetical role of allergen immunoprophylaxis or immunotherapy in LAR. Last, the term 'local allergic rhinitis' may be inappropriate, as rhinitis is always 'local', while IgE sensitization can be either 'local' or 'systemic'. PMID:27098888

  11. Treatment of 82 Cases of Allergic Rhinitis with Aconite Cake-partitioned Moxibustion

    Institute of Scientific and Technical Information of China (English)

    胡志平; 李小军; 黄克伟; 洪珏

    2010-01-01

    @@ Allergic rhinitis is mainly characterized by recurrent sneezing and runny nose.The author has treated 82 cases of allergic rhinitis with aconite cake-partitioned moxibustion and now it is reported as follows.

  12. Treatment of allergic rhinitis is associated with improved attention performance in children: the Allergic Rhinitis Cohort Study for Kids (ARCO-Kids.

    Directory of Open Access Journals (Sweden)

    Dong-Kyu Kim

    Full Text Available BACKGROUND: It has been well known that pediatric allergic rhinitis was associated with poor performance at school due to attention deficit. However, there were no cohort studies for the effect of treatment of allergic rhinitis on attention performance in pediatric population. Thus, the aim of this study was to investigate whether attention performance was improved after treatment in children with allergic rhinitis. METHODS: In this ARCO-Kids (Allergic Rhinitis Cohort Study for Kids, consecutive pediatric patients with rhinitis symptoms underwent a skin prick test and computerized comprehensive attention test. According to the skin prick test results, the children were diagnosed as allergic rhinitis or non- allergic rhinitis. All of the patients were regularly followed up and treated with oral medication or intranasal corticosteroid sprays. The comprehensive attention tests consisted of sustained and divided attention tasks. Each of the tasks was assessed by the attention score which was calculated by the number of omission and commission errors. The comprehension attention test was repeated after 1 year. RESULTS: A total of 797 children with allergic rhinitis and 239 children with non-allergic rhinitis were included. Initially, the attention scores of omission and commission errors on divided attention task were significantly lower in children with allergic rhinitis than in children with non-allergic rhinitis. After 1 year of treatment, children with allergic rhinitis showed improvement in attention: commission error of sustained (95.6±17.0 vs 97.0±16.6 and divided attention task (99.1±15.8 vs 91.8±23.5. Meanwhile, there was no significant difference of attention scores in children with non-allergic rhinitis. CONCLUSIONS: Our study showed that management of allergic rhinitis might be associated with improvement of attention.

  13. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis

    DEFF Research Database (Denmark)

    Chawes, Bo Lk

    2011-01-01

    Allergic- and non-allergic rhinitis are very common diseases in childhood in industrialized countries. Although these conditions are widely trivialized by both parents and physicians they induce a major impact on quality of life for the affected children and a substantial drainage of health care...... resources. Unfortunately, diagnostic specificity is hampered by nonspecific symptom history and lack of reliable diagnostic tests which may explain why the pathology behind such diagnoses is poorly understood. Improved understanding of the pathophysiology of allergic- and non-allergic rhinitis in young...... children may contribute to the discovery of new mechanisms involved in pathogenesis and help direct future research to develop correctly timed preventive measures as well as adequate monitoring and treatment of children with rhinitis. Asthma is a common comorbidity in subjects with allergic rhinitis...

  14. Association between allergic rhinitis and asthma in a Northern Alberta cohort

    OpenAIRE

    Jeffery, Caroline C.; Bhutani, Mohit; Vliagoftis, Harissios; Wright, Erin D; Seikaly, Hadi; Côté, David WJ

    2013-01-01

    Background Many published epidemiologic studies confirm a marked increase in the prevalence of asthma and allergic rhinitis. The link between allergic rhinitis and asthma has been extensively studied and approximately 75% of patients with asthma have allergic rhinitis. The proportion of patients with asthma in populations of allergic rhinitis patients has not been well studied. Objective The purpose of this study is to estimate the prevalence of undiagnosed asthma in a specific population of ...

  15. Treatment trends in allergic rhinitis and asthma: a British ENT survey

    OpenAIRE

    Theochari Eva G; Natt Davinia K; Karkos Petros D; Natt Ravinder S; Karkanevatos Apostolos

    2011-01-01

    Abstract Background Allergic Rhinitis is a common Ear, Nose and Throat disorder. Asthma and Allergic Rhinitis are diseases with similar underlying mechanism and pathogenesis. The aim of this survey was to highlight current treatment trends for Allergic Rhinitis and Asthma. Method A questionnaire was emailed to all registered consultant members of the British Association of Otorhinolaryngologists - Head and Neck Surgeons regarding the management of patients with Allergic Rhinitis and related d...

  16. PSYCHO-EMOTIONAL CHARACTERISTICS OF THE ADOLESCENTS WITH ALLERGIC RHINITIS.

    Science.gov (United States)

    Adamia, N; Jorjoliani, L; Manjavidze, N; Ubiria, I; Saginadze, L

    2015-06-01

    Allergic rhinitis is a widespread allergic disease, with 35-40% prevalence in the world population. It is characterized with increasing frequency, particularly in children's population. Goal of the work - study of psycho-emotional profile in adolescents with allergic rhinitis of different severity. Single-stage research was conducted, in compliance with the ethical norms. Study included 86 children (41% girls and 45% boys) of age from 11 to 13 years with allergic rhinitis of different severity and 30 healthy children. For the purpose of study of the patients' psychological profile Esenek Personality Questionnaire (EPQ) intended for assessment of characterological and individual psychological features in children and adolescents (10-15 years) was used. Psycho-emotional sphere of the adolescents with allergic rhinitis was assessed also by Psychopathologic Symptom Checklist (Symptom Checklist-90-Revised-SCL-90-R). Clinical scale of self-assessment of psychical condition is widely applied in ambulatory and hospital practice. At the final stage of research the mathematical-statistical data processing was provided by means of SPSS/v12 software package. According to the research results, susceptibility to significant and mild introversion was identified in severe and average AR cases. Such patients are often locked into their inner world. These children are reserved, communicate with the parents and close friends only. They make decisions with due care, love order, control their emotions, are pessimistic and rarely aggressive. Results of neuroticism study by G. Esenek techniques are provided in Table. Neuroticism is associated with the lability of nervous system, characterizes emotional condition or emotional lability (emotional stability or instability). According to the research results, allergic rhinitis is characterized with emotional instability, anxiety, as manifested by unsatisfactory adaptation, instable nature, depression, low resistance to the stress situations

  17. Efficacy of desloratadine in persistent allergic rhinitis - a GA²LEN study

    DEFF Research Database (Denmark)

    Bousquet, Jean; Bachert, Claus; Canonica, Giorgio W;

    2010-01-01

    The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent or persistent) rather than on the time of allergen exposure (seasonal or perennial). There had been no placebo-controlled, randomized......, clinical trial of desloratadine (DL) in patients with persistent allergic rhinitis to date....

  18. Allergic rhinitis is associated with poor asthma control in children with asthma

    NARCIS (Netherlands)

    de Groot, Eric P.; Nijkamp, Anke; Duiverman, Eric J.; Brand, Paul L. P.

    2012-01-01

    Background Asthma and allergic rhinitis are the two most common chronic disorders in childhood and adolescence. To date, no study has examined the impact of comorbid allergic rhinitis on asthma control in children. Objective To examine the prevalence of allergic rhinitis in children with asthma, and

  19. Clinical Experience in Acupuncture Treatment of Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yan-qiu

    2009-01-01

    Objective:To observe the clinical effects of acupuncture for allergic rhinitis.Methods:The body acupuncture, auricular seed-embedding and microwave irradiation were adopted for treatment of allergic rhinitis due to various causative factors, such as cold and insufficiency of the lung-qi weakening the body resistance, insufficiency of the spleen-qi with lucid yang failing to rise, insufficiency of the kidney-yang failing to warm the body surface, and the heat accumulated in the lung channels giving invading the nose.Results:After treatment, the symptoms and signs disappeared in all illustrative cases, with no recurrence found after a one-year follow-up.Conclusion:Acupuncture may help to improve the blood rheology indexes with an increased volume of blood flow, and regulate the immunological function of the human body, thus giving therapeutic effects for allergic rhinitis.

  20. [Therapy of allergic rhinitis: the preferences of specialists].

    Science.gov (United States)

    Danilova, K V; Razdorskaia, I M

    2014-01-01

    The objective of the present work was to study the stereotypes of addressing such a serious medical problem as the treatment of allergic rhinitis by practicing physicians and the development of criteria for the priority choice of pharmaceutical products to be prescribed to the patients presenting with this pathology. This pharmacoepidemiological investigation was designed to elucidate the preferences shown by specialists dealing with this disease. The special questionnaire was developed to collect and analyse the opinions of otorhinolaryngologists and allergologists. The study has demonstrated that both therapy of allergic rhinitis and preferences of specialists conform with the respective international standards. However, the study revealed the lack of the adequate communicative and informational interactions between two basic components of the healthcare system, viz. doctors and pharmacists. The authors emphasize the necessity to optimize professional approaches to the management of allergic rhinitis.

  1. Frequency of Mold Allergens in Allergic Rhinitis Patients

    Directory of Open Access Journals (Sweden)

    Bonyadi, MR. (PhD

    2014-06-01

    Full Text Available Background and Objective: Allergic rhinitis can be stimulated by several allergens. Molds are among these allergens and it is important to assess their frequency in different geographic area. Hence, we aimed at determining the frequency of mold allergens in allergic rhinitis patients referred to specialized clinics of Tabriz Imam Reza hospital, 2011. Material and Methods: This cross-sectional study was conducted on the serums of 90 rhinitis patients diagnosed by specialized physician. Using Immunoblotting method, the level of specific IgE against four molds including Penicillium, Aspergillus, Alternaria and Cladosporium were investigated. Results: Of 90 Patients, 40 were men (44.4% and 50 were women (55.6%. The participants were between 6 to 53 years and the most were 28-31years. The allergy was related to Penicillium (3.3%, Aspergillus (5.6%, Alternaria (13.3% and Cladosporium (4.4%. There was a significant statistical relation between age and allergic rhinitis to Alternaria (P=0.011. Conclusion: Molds can grow and proliferate in very humid environments. Because of low humidity climate in Tabriz (in the northwest of Iran, allergy to molds is relatively low in this region. Key words: Rhinitis Allergic; Mold; Allergy

  2. [Allergic inflamation of the lower airways in patients with allergic rhinitis].

    Science.gov (United States)

    Stefanović, Lj; Balaban, J; Stosović, R; Mitrović, N; Djurasinović, M; Tanurdzić, S

    1994-01-01

    Reporting two of our cases we wanted to point to a great dilemma related to the final diagnosis. Recently, such cases have been more frewuently seen, since in all patients with allergic rhinitis conditions of the lower airways is examined before the administration of the specific immunotherapy. Therefore, we may see patients who are still free of pulmonary sings, despite of positive specific and/or non specific bronchoprovocative tests. The presented cases with evidenced allergic rhinitis are probably in the phase of development of allergic bronchial asthma, the phase of "allergic inflammation" of the lower airways, not clinically manifested yet. PMID:18173213

  3. Allergic Sensitization, Rhinitis and Tobacco Smoke Exposure in US Adults.

    Directory of Open Access Journals (Sweden)

    Josef Shargorodsky

    Full Text Available Tobacco exposure has been linked with sinonasal pathology and may be associated with allergic sensitization. This study evaluates the association between exposure to active smoking or secondhand smoke (SHS and the prevalence of rhinitis and allergic sensitization in the US adult population.Cross-sectional study in 4,339 adults aged 20-85 in the National Health and Nutrition Examination Survey, 2005-2006. Never smoking was defined as reported lifetime smoking less than 100 cigarettes and serum cotinine levels 10 ng/mL. Self-reported rhinitis was based on symptoms during the past 12 months, and allergen sensitization was defined as a positive response to any of the 19 specific IgE antigens tested.Almost half of the population (43% had detectable levels of IgE specific to at least one inhaled allergen and 32% reported a history of rhinitis. After multivariate adjustment, there was a statistically significant association between the highest serum cotinine tertile and rhinitis in active smokers (OR 1.42; 95%CI 1.00-2.00. The association between active smoking and rhinitis was stronger in individuals without allergic sensitization (OR 2.47; 95%CI 1.44-4.23. There was a statistically significant association between increasing cotinine tertiles and decreased odds of inhaled allergen sensitization (p-trend <.01.Tobacco smoke exposure was associated with increased prevalence of rhinitis symptoms, but not with allergic sensitization. The results indicate that the relationship between tobacco smoke exposure and sinonasal pathology in adults may be independent of allergic sensitization.

  4. Effect of Botulinum Neurotoxin A Injection into the Submucoperichondrium of the Nasal Septum in Reducing Idiopathic Non-Allergic Rhinitis and Persistent Allergic Rhinitis

    OpenAIRE

    Mozafarinia, Keramat; Abna, Mehdi; Narges KHANJANI

    2015-01-01

    Introduction: Submucoperichondrial injection of botulinum neurotoxin A (BTA) in the nasal septum is a promising therapeutic option in the treatment of persistent allergic rhinitis (AR) and non-allergic rhinitis, and is safer and more effective than intraturbinate injection in reducing clinical symptoms. Materials and Methods: Forty patients diagnosed with persistent AR or non-allergic rhinitis referred to Shafa Medical Center affiliated to Kerman University of Medical Sciences were included i...

  5. Allergic Rhinitis and Pharmacological Management in Elite Athletes

    OpenAIRE

    Alaranta, A.; Alaranta, H.; Heliövaara, M.; Alha, P.; Palmu, P.; Helenius, I

    2005-01-01

    Introduction: Only a few studies have examined the occurrence of atopy and clinically apparent allergic disease and their pharmacological management in elite athletes. The aim of the study was to assess the frequency of allergic rhinitis and the use of antiallergic medication within the subgroups of elite athletes as compared with a representative sample of young adults of the same age. Methods: A cross-sectional survey was carried out in 2002. All the athletes (N = 494) financially suppo...

  6. Treatment trends in allergic rhinitis and asthma: a British ENT survey

    Directory of Open Access Journals (Sweden)

    Theochari Eva G

    2011-04-01

    Full Text Available Abstract Background Allergic Rhinitis is a common Ear, Nose and Throat disorder. Asthma and Allergic Rhinitis are diseases with similar underlying mechanism and pathogenesis. The aim of this survey was to highlight current treatment trends for Allergic Rhinitis and Asthma. Method A questionnaire was emailed to all registered consultant members of the British Association of Otorhinolaryngologists - Head and Neck Surgeons regarding the management of patients with Allergic Rhinitis and related disorders. Results Survey response rate was 56%. The results indicate a various approach in the investigation and management of Allergic Rhinitis compatible with recommendations from the Allergic Rhinitis and Its Impact on Asthma guidelines in collaboration with the World Health Organisation. Conclusion A combined management approach for patients with Allergic Rhinitis and concomitant Asthma may reduce medical treatment costs for these conditions and improve symptom control and quality of life.

  7. Non-allergic rhinitis: a case report and review

    Directory of Open Access Journals (Sweden)

    Betty Lew D

    2010-02-01

    Full Text Available Abstract Rhinitis is characterized by rhinorrhea, sneezing, nasal congestion, nasal itch and/or postnasal drip. Often the first step in arriving at a diagnosis is to exclude or diagnose sensitivity to inhalant allergens. Non-allergic rhinitis (NAR comprises multiple distinct conditions that may even co-exist with allergic rhinitis (AR. They may differ in their presentation and treatment. As well, the pathogenesis of NAR is not clearly elucidated and likely varied. There are many conditions that can have similar presentations to NAR or AR, including nasal polyps, anatomical/mechanical factors, autoimmune diseases, metabolic conditions, genetic conditions and immunodeficiency. Here we present a case of a rare condition initially diagnosed and treated as typical allergic rhinitis vs. vasomotor rhinitis, but found to be something much more serious. This case illustrates the importance of maintaining an appropriate differential diagnosis for a complaint routinely seen as mundane. The case presentation is followed by a review of the potential causes and pathogenesis of NAR.

  8. The Prevalence of Allergic Rhinitis in Patients with Chronic Rhinosinusitis

    Directory of Open Access Journals (Sweden)

    Mehdi Bakhshaee

    2014-10-01

    Full Text Available Introduction: Chronic rhinosinusitis (CRS is a multifactorial disease. Allergies are considered a predisposing factor to CRS; however, this remains controversial. The objective of this research was to investigate the prevalence of co-morbidities and allergic reaction, and to specify the most common allergens in patients with confirmed CRS.   Materials and Methods: One hundred patients with signs and symptoms of CRS who met the diagnostic endoscopic and radiologic criteria of chronic rhinosinusitis were selected. They filled out a questionnaire and underwent a skin prick test for the common inhalant allergens. Allergic rhinitis was diagnosed according to the history and positive skin prick tests.   Results: The mean age of patients was 34. Males were slightly more involved (54%. The prevalence of polypoid and none-polypoid rhinosinusitis was 54% and 46% respectively. The patients’ most common symptoms were nasal discharge (95%, blockage (94%, smell disorders (63%, cough (45%, halitosis (41%, lethargy (37%, and aural fullness (36%. Allergy to at least one allergen was noted in 64% of the CRS patients which is higher than general population in Mashhad, Iran with allergic rhinitis (22.4%. Salsola was the most common allergen. There was no significant difference in allergic reactions between polypoid and non-polypoid CRS patients.   Conclusion:  Allergic reactions was found in Iranian CRS patients with or without polyposis to be much higher than general population in Mashhad with allergic rhinitis alone.

  9. Is allergic rhinitis a trivial disease?

    Directory of Open Access Journals (Sweden)

    Dirceu Solé

    2011-01-01

    Full Text Available BACKGROUND: Asthma and rhinitis often coexist, which potentially increases the disease severity and can negatively impact a patients' quality of life. However, there are few reports based on data obtained from the International Study of Asthma and Allergies in Childhood examining asthma severity in combination with rhinitisrelated symptoms. OBJECTIVE: To demonstrate whether current rhinitis and current rhinoconjunctivitis are associated with the development of asthma or its increasing severity in Brazilian adolescents. METHODS: The prevalence of current asthma was correlated with the prevalence of current rhinitis and current rhinoconjunctivitis in adolescents (13 to 14 year olds from 16 Brazilian centers (based on Spearman's rank correlation index. The influence of current rhinitis and current rhinoconjunctivitis on asthma presentation was also evaluated using the chi-squared test and was expressed as odds ratios with 95% confidence intervals (95%CI. RESULTS: A significant positive correlation was observed between the prevalence of current asthma and current rhinitis (rs = 0.82; 95%CI: 0.60-0.93, p< 0.0001 and between the prevalence of current asthma and current rhinoconjunctivitis (rs = 0.75; 95%CI: 0.47-0.89, p < 0.0001. Current rhinitis was associated with a significantly increased risk of current asthma and of more severe asthma. Similar results were observed for current rhinoconjunctivitis. CONCLUSION: In this epidemiologic study of Brazilian adolescents, the presence of current rhinitis and current rhinoconjunctivitis was associated with a high risk of developing asthma and increased asthma severity. The mutual evaluation of rhinitis and asthma is necessary to establish an adequate treatment plan.

  10. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis

    DEFF Research Database (Denmark)

    Chawes, Bo

    2011-01-01

    resources. Unfortunately, diagnostic specificity is hampered by nonspecific symptom history and lack of reliable diagnostic tests which may explain why the pathology behind such diagnoses is poorly understood. Improved understanding of the pathophysiology of allergic- and non-allergic rhinitis in young...... children may contribute to the discovery of new mechanisms involved in pathogenesis and help direct future research to develop correctly timed preventive measures as well as adequate monitoring and treatment of children with rhinitis. Asthma is a common comorbidity in subjects with allergic rhinitis...... airway patencies were strongly associated and independent of body size, rhinitis and asthma. The association was consistent for both baseline values and for decongested nasal airway patency and post-β2 FEV1. Blood and nasal eosinophilia were also associated with nasal airway obstruction. This suggests...

  11. Observation on Therapeutic Effects of Cupping Therapy for Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    许荣正; 朱雪兰; 吴国民; 黄国琪

    2010-01-01

    @@ Allergic rhinitis is mainly characterized by the symptoms of sneezing,tickling sensation in the nose,runny nose,and nasal obstruction,and often occurs after invasion of pathogenic wind and cold.The author has treated 50 cases of this disease by applying cupping therapy on Shenque (CV 8).Now,the report is given as follows.

  12. Relation between air pollution and allergic rhinitis in Taiwanese schoolchildren

    Directory of Open Access Journals (Sweden)

    Lee Yung-Ling

    2006-02-01

    Full Text Available Abstract Background Recent findings suggest that exposure to outdoor air pollutants may increase the risk of allergic rhinitis. The results of these studies are inconsistent, but warrant further attention. The objective of the study was to assess the effect of relation between exposure to urban air pollution and the prevalence allergic rhinitis among school children. Methods We conducted a nationwide cross-sectional study of 32,143 Taiwanese school children. We obtained routine air-pollution monitoring data for sulphur dioxide (SO2, nitrogen oxides (NOx, ozone (O3, carbon monoxide (CO, and particles with an aerodynamic diameter of 10 μm or less (PM10. A parent-administered questionnaire provided information on individual characteristics and indoor environments (response rate 92%. Municipal-level exposure was calculated using the mean of the 2000 monthly averages. The effect estimates were presented as odds ratios (ORs per 10 ppb change for SO2, NOx, and O3, 100 ppb change for CO, and 10 μg/m3 change for PM10. Results In two-stage hierarchical model adjusting for confounding, the prevalence of allergic rhinitis was significantly associated with SO2 (adjusted odds ratio (OR = 1.43, 95% confidence interval (CI: 1.25, 1.64, CO (aOR = 1.05, 95% CI: 1.04, 1.07, and NOx (aOR = 1.11, 95% CI: 1.08, 1.15. Contrary to our hypothesis, the prevalence of allergic rhinitis was weakly or not related to O3 (aOR = 1.05, 95% CI: 0.98, 1.12 and PM10 (aOR = 1.00, 95% CI: 0.99, 1.02. Conclusion Persistent exposure to NOx, CO, and SO2 may increase the prevalence of allergic rhinitis in children.

  13. Attention Deficit Hyperactivity Disorder Like Behavioral Problems and Parenting Stress in Pediatric Allergic Rhinitis

    OpenAIRE

    Lee, Young Sik; Kim, Se Hee; You, Ji Hee; Baek, Hyung Tae; Na, Chul; Kim, Bung Nyun; Han, Doug Hyun

    2014-01-01

    Objective Previous studies have reported comorbidity of attention deficit and hyperactivity disorder (ADHD) and allergic diseases. The current study investigated ADHD like behavioral symptoms and parenting stress in pediatric allergic rhinitis. Methods Eighty-seven children (6-13 years old) with allergic rhinitis and 73 age- and sex-matched children of control group were recruited. Diagnosis and severity assessments of allergic rhinitis were determined by a pediatric allergist. The Parenting ...

  14. Allergic Rhinitis and its Impact on Asthma (ARIA) : Achievements in 10 years and future needs

    NARCIS (Netherlands)

    Bousquet, J.; Schuenemann, H. J.; Samolinski, B.; Demoly, P.; Baena-Cagnani, C. E.; Bachert, C.; Bonini, S.; Boulet, L. P.; Bousquet, P. J.; Brozek, J. L.; Canonica, G. W.; Casale, T. B.; Cruz, A. A.; Fokkens, W. J.; Fonseca, J. A.; van Wijk, R. Gerth; Grouse, L.; Haahtela, T.; Khaltaev, N.; Kuna, P.; Lockey, R. F.; Carlsen, K. C. Lodrup; Mullol, J.; Naclerio, R.; O'Hehir, R. E.; Ohta, K.; Palkonen, S.; Papadopoulos, N. G.; Passalacqua, G.; Pawankar, R.; Price, D.; Ryan, D.; Simons, F. E. R.; Togias, A.; Williams, D.; Yorgancioglu, A.; Yusuf, O. M.; Aberer, W.; Adachi, M.; Agache, I.; Ait-Khaled, N.; Akdis, C. A.; Andrianarisoa, A.; Annesi-Maesano, I.; Ansotegui, I. J.; Baiardini, I.; Bateman, E. D.; Bedbrook, A.; Beghe, B.; Beji, M.; Bel, E. H.; Ben Kheder, A.; Bennoor, K. S.; Bergmann, K. C.; Berrissoul, F.; Bieber, T.; Jensen, C. Bindslev; Blaiss, M. S.; Boner, A. L.; Bouchard, J.; Braido, F.; Brightling, C. E.; Bush, A.; Caballero, F.; Calderon, M. A.; Calvo, M. A.; Camargos, P. A. M.; Caraballo, L. R.; Carlsen, K. H.; Carr, W.; Cepeda, A. M.; Cesario, A.; Chavannes, N. H.; Chen, Y. Z.; Chiriac, A. M.; Chivato Perez, T.; Chkhartishvili, E.; Ciprandi, G.; Costa, D. J.; Cox, L.; Custovic, A.; Dahl, R.; Darsow, U.; De Blay, F.; Deleanu, D.; Denburg, J. A.; Devillier, P.; Didi, T.; Dokic, D.; Dolen, W. K.; Douagui, H.; Dubakiene, R.; Durham, S. R.; Dykewicz, M. S.; El-Gamal, Y.; El-Meziane, A.; Emuzyte, R.; Fiocchi, A.; Fletcher, M.; Fukuda, T.; Gamkrelidze, A.; Gereda, J. E.; Gonzalez Diaz, S.; Gotua, M.; Guzman, M. A.; Hellings, P. W.; Hellquist-Dahl, B.; Horak, F.; Hourihane, J. O'B.; Howarth, P.; Humbert, M.; Ivancevich, J. C.; Jackson, C.; Just, J.; Kalayci, O.; Kaliner, M. A.; Kalyoncu, A. F.; Keil, T.; Keith, P. K.; Khayat, G.; Kim, Y. Y.; N'Goran, B. Koffi; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kvedariene, V.; Larenas-Linnemann, D.; Le, L. T.; Lemiere, C.; Li, J.; Lieberman, P.; Lipworth, B.; Mahboub, B.; Makela, M. J.; Martin, F.; Marshall, G. D.; Martinez, F. D.; Masjedi, M. R.; Maurer, M.; Mavale-Manuel, S.; Mazon, A.; Melen, E.; Meltzer, E. O.; Mendez, N. H.; Merk, H.; Mihaltan, F.; Mohammad, Y.; Morais-Almeida, M.; Muraro, A.; Nafti, S.; Namazova-Baranova, L.; Nekam, K.; Neou, A.; Niggemann, B.; Nizankowska-Mogilnicka, E.; Nyembue, T. D.; Okamoto, Y.; Okubo, K.; Orru, M. P.; Ouedraogo, S.; Ozdemir, C.; Panzner, P.; Pali-Schoell, I.; Park, H. S.; Pigearias, B.; Pohl, W.; Popov, T. A.; Postma, D. S.; Potter, P.; Rabe, K. F.; Ratomaharo, J.; Reitamo, S.; Ring, J.; Roberts, R.; Rogala, B.; Romano, A.; Rodriguez, M. Roman; Rosado-Pinto, J.; Rosenwasser, L.; Rottem, M.; Sanchez-Borges, M.; Scadding, G. K.; Schmid-Grendelmeier, P.; Sheikh, A.; Sisul, J. C.; Sole, D.; Sooronbaev, T.; Spicak, V.; Spranger, O.; Stein, R. T.; Stoloff, S. W.; Sunyer, J.; Szczeklik, A.; Todo-Bom, A.; Toskala, E.; Tremblay, Y.; Valenta, R.; Valero, A. L.; Valeyre, D.; Valiulis, A.; Valovirta, E.; Van Cauwenberge, P.; Vandenplas, O.; van weel, C.; Vichyanond, P.; Viegi, G.; Wang, D. Y.; Wickman, M.; Woehrl, S.; Wright, J.; Yawn, B. P.; Yiallouros, P. K.; Zar, H. J.; Zernotti, M. E.; Zhong, N.; Zidarn, M.; Zuberbier, T.

    2012-01-01

    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclas

  15. Role of Predatory Mites in Persistent Nonoccupational Allergic Rhinitis

    Science.gov (United States)

    Poza Guedes, Paloma; Sánchez Machín, Inmaculada; Matheu, Víctor; Iraola, Víctor

    2016-01-01

    Mites can sensitize and induce atopic disease in predisposed individuals and are an important deteriorating factor in patients with allergic rhinitis, asthma, and atopic dermatitis. Although Pyroglyphidae mites have been extensively studied, very scarce reports are available on Cheyletidae spp. especially regarding human respiratory pathology. The main objective of the present study is to investigate the clinical role of this predator mite (Cheyletus eruditus) as a respiratory antigen in a selected sensitized human population. Fifty-two adult patients were recruited from the outpatient allergy clinic to assess their eligibility for the study. The thirty-seven subjects with persistent allergic rhinitis (PAR) who fulfilled the ARIA criteria had a positive IgE response confirmed by skin prick test (SPT) to C. eruditus. Only those individuals (37/47) with a positive SPT to C. eruditus showed a positive nasal provocation test (NPT), while 10 patients with nonallergic mild-to-moderate persistent rhinitis, control group, had a negative NPT with C. eruditus. The present paper describes a new role for the predator mite Cheyletus eruditus as a respiratory allergen in a selected subset of patients in a subtropical environment afflicted with persistent nonoccupational allergic rhinitis. PMID:27445552

  16. Role of Predatory Mites in Persistent Nonoccupational Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Paloma Poza Guedes

    2016-01-01

    Full Text Available Mites can sensitize and induce atopic disease in predisposed individuals and are an important deteriorating factor in patients with allergic rhinitis, asthma, and atopic dermatitis. Although Pyroglyphidae mites have been extensively studied, very scarce reports are available on Cheyletidae spp. especially regarding human respiratory pathology. The main objective of the present study is to investigate the clinical role of this predator mite (Cheyletus eruditus as a respiratory antigen in a selected sensitized human population. Fifty-two adult patients were recruited from the outpatient allergy clinic to assess their eligibility for the study. The thirty-seven subjects with persistent allergic rhinitis (PAR who fulfilled the ARIA criteria had a positive IgE response confirmed by skin prick test (SPT to C. eruditus. Only those individuals (37/47 with a positive SPT to C. eruditus showed a positive nasal provocation test (NPT, while 10 patients with nonallergic mild-to-moderate persistent rhinitis, control group, had a negative NPT with C. eruditus. The present paper describes a new role for the predator mite Cheyletus eruditus as a respiratory allergen in a selected subset of patients in a subtropical environment afflicted with persistent nonoccupational allergic rhinitis.

  17. Acupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol

    OpenAIRE

    Kang Kyung-Won; Shin Mi-Suk; Kim Ae-Ran; Zhao Jiping; Zhao Hong; Ko Jeong-Min; Lee Sanghoon; Choi Jun-Yong; Jung So-Young; Lee Myeong Soo; Kim Jong-In; Jung Hee-Jung; Kim Tae-Hun; Liu Baoyan; Choi Sun-Mi

    2009-01-01

    Abstract Background Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects of conventional medication. Acupuncture has been widely used to treat patients with allergic rhinitis, but the available evidence of its effectiveness is insufficient. Our objective is to evaluate the effectiveness of acupuncture in patients in Korea and China with pe...

  18. Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments

    OpenAIRE

    Segundo, Gesmar RS; Gomes, Fabíola A; Karla P. Fernandes; Alves, Ronaldo; Silva, Deise AO; Taketomi, Ernesto A.

    2009-01-01

    Background Therapy for allergic rhinitis aims to control symptoms and improve the quality of life. The treatment of allergic rhinitis includes allergen avoidance, environmental controls, pharmacologic treatment, and specific immunotherapy. Objectives The aim of this study is to evaluate the clinical changes and the levels of interferon-γ (IFN-γ) and interleukin-5 (IL-5) in nasal lavage fluid from children with allergic rhinitis after different types of pharmacologic treatment (mometasone, mon...

  19. 173 Relationship Between Allergic Rhinitis and Dental-Facial Abnormalities

    OpenAIRE

    Medina, Miguel Alejandro

    2012-01-01

    Background Allergic rhinitis (AR) affects 10 to 25% of the general population and is of great importance for the impact on quality of life and school performance.1 Rhinitis has been associated with craniofacial abnormalities due to the high frequency of mouth breathing, oral breathing syndrome occurs when the child replaces the correct pattern of breathing caused by nasal obstruction resulting from allergic disease.2 Objective To establish the type of relationship between allergic rhinitis an...

  20. Development process and cognitive testing of CARATkids - Control of Allergic Rhinitis and Asthma Test for children

    OpenAIRE

    Borrego, LM; fonseca, ja; Pereira, AM; Reimão Pinto, V; LINHARES D.; Morais-Almeida, M

    2014-01-01

    Background: Allergic rhinitis and asthma (ARA) are chronic inflammatory diseases of the airways that often coexist in children. The only tool to assess the ARA control, the Control of Allergic Rhinitis and Asthma Test (CARAT) is to be used by adults. We aimed to develop the Pediatric version of Control of Allergic Rhinitis and Asthma Test (CARATkids) and to test its comprehensibility in children with 4 to 12 years of age. Methods: The questionnaire development included a literature revi...

  1. Cetirizine and astemizole in allergic rhinitis a comparative study

    OpenAIRE

    Jain, R K

    1999-01-01

    The efficacy, safety and side effects of Cetirizine and Astemizole were compared with Pheniramine maleate in sixty cases of allergic rhinitis. All medications were stopped one week prior to treatment. Cetirizine, Astemizole or Pheniramine maleate were given as a single daily dose for 15 days. On completion of treatment results were evaluated subjectively as well as objectively, Cetirizine and Astemizole were found to be more effective than Pheniramine maleate. The side effects were minimum wi...

  2. Cystatin SN Upregulation in Patients with Seasonal Allergic Rhinitis

    OpenAIRE

    Yoshimasa Imoto; Takahiro Tokunaga; Yuri Matsumoto; Yuko Hamada; Mizuho Ono; Takechiyo Yamada; Yumi Ito; Tadao Arinami; Mitsuhiro Okano; Emiko Noguchi; Shigeharu Fujieda

    2013-01-01

    Seasonal allergic rhinitis (SAR) to the Japanese cedar, Cryptomeria japonica (JC) pollen is an IgE-mediated type I allergy affecting nasal mucosa. However, the molecular events underlying its development remain unclear. We sought to identify SAR-associated altered gene expression in nasal epithelial cells during natural exposure to JC pollen. We recruited study participants in 2009 and 2010 and collected nasal epithelial cells between February and April, which is the period of natural pollen ...

  3. Role of Predatory Mites in Persistent Nonoccupational Allergic Rhinitis

    OpenAIRE

    Paloma Poza Guedes; Inmaculada Sánchez Machín; Víctor Matheu; Víctor Iraola; Ruperto González Pérez

    2016-01-01

    Mites can sensitize and induce atopic disease in predisposed individuals and are an important deteriorating factor in patients with allergic rhinitis, asthma, and atopic dermatitis. Although Pyroglyphidae mites have been extensively studied, very scarce reports are available on Cheyletidae spp. especially regarding human respiratory pathology. The main objective of the present study is to investigate the clinical role of this predator mite (Cheyletus eruditus) as a respiratory antigen in a se...

  4. Quality of Sexual Life in Males with Allergic Rhinitis

    OpenAIRE

    Gul Soylu Ozler

    2014-01-01

    Aim: The aim of this study is to evaluate the quality of sexual life of males with allergic rhinitis(AR). Material and Method: 40 patients with AR diagnosed with skin prick test and 40 control subjects with no evidence of allergy completed the study. International Index of Erectile Function questionnaire (IIEF) was used to evaluate the quality of sexual life of the subjects. Results: The mean scores of erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall s...

  5. Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study

    DEFF Research Database (Denmark)

    Bousquet, J; Bachert, C; Canonica, G W;

    2009-01-01

    BACKGROUND: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent, persistent) rather than on the time of allergen exposure (seasonal, perennial). There is no placebo-controlled, randomized...... clinical trial on intermittent allergic rhinitis (IAR) to date. Desloratadine (DL) is recommended for the first-line treatment of seasonal and perennial allergic rhinitis. OBJECTIVES: To assess the efficacy and safety of DL in subjects with IAR based on the ARIA classification. METHODS: Patients over 12...

  6. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis) : the new generation guideline implementation

    NARCIS (Netherlands)

    Bousquet, J.; Schunemann, H. J.; Fonseca, J.; Samolinski, B.; Bachert, C.; Canonica, G. W.; Casale, T.; Cruz, A. A.; Demoly, P.; Hellings, P.; Valiulis, A.; Wickman, M.; Zuberbier, T.; Bosnic-Anticevitch, S.; Bedbrook, A.; Bergmann, K. C.; Caimmi, D.; Dahl, R.; Fokkens, W. J.; Grisle, I.; Lodrup Carlsen, K.; Mullol, J.; Muraro, A.; Palkonen, S.; Papadopoulos, N.; Passalacqua, G.; Ryan, D.; Valovirta, E.; Yorgancioglu, A.; Aberer, W.; Agache, I.; Adachi, M.; Akdis, C. A.; Akdis, M.; Annesi-Maesano, I.; Ansotegui, I. J.; Anto, J. M.; Arnavielhe, S.; Arshad, H.; Baiardini, I.; Baigenzhin, A. K.; Barbara, C.; Bateman, E. D.; Beghe, B.; Bel, E. H.; Ben Kheder, A.; Bennoor, K. S.; Benson, M.; Bewick, M.; Bieber, T.; Bindslev-Jensen, C.; Bjermer, L.; Blain, H.; Boner, A. L.; Boulet, L. P.; Bonini, M.; Bonini, S.; Bosse, I.; Bourret, R.; Bousquet, P. J.; Braido, F.; Briggs, A. H.; Brightling, C. E.; Brozek, J.; Buhl, R.; Burney, P. G.; Bush, A.; Caballero-Fonseca, F.; Calderon, M. A.; Camargos, P. A. M.; Camuzat, T.; Carlsen, K. H.; Carr, W.; Sarabia, A. M. Cepeda; Chavannes, N. H.; Chatzi, L.; Chen, Y. Z.; Chiron, R.; Chkhartishvili, E.; Chuchalin, A. G.; Ciprandi, G.; Cirule, I.; Correia de Sousa, J.; Cox, L.; Crooks, G.; Costa, D. J.; Custovic, A.; Dahlen, S. E.; Darsow, U.; De Carlo, G.; De Blay, F.; Dedeu, T.; Deleanu, D.; Denburg, J. A.; Devillier, P.; Didier, A.; Dinh-Xuan, A. T.; Dokic, D.; Douagui, H.; Dray, G.; Dubakiene, R.; Durham, S. R.; Dykewicz, M. S.; El-Gamal, Y.; Emuzyte, R.; Wagner, A. Fink; Fletcher, M.; Fiocchi, A.; Forastiere, F.; Gamkrelidze, A.; Gemicioglu, B.; Gereda, J. E.; Gonzalez Diaz, S.; Gotua, M.; Grouse, L.; Guzman, M. A.; Haahtela, T.; Hellquist-Dahl, B.; Heinrich, J.; Horak, F.; Hourihane, J. O. B.; Howarth, P.; Humbert, M.; Hyland, M. E.; Ivancevich, J. C.; Jares, E. J.; Johnston, S. L.; Joos, G.; Jonquet, O.; Jung, K. S.; Just, J.; Kaidashev, I.; Kalayci, O.; Kalyoncu, A. F.; Keil, T.; Keith, P. K.; Khaltaev, N.; Klimek, L.; N'Goran, B. Koffi; Kolek, V.; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kuna, P.; Kvedariene, V.; Lambrecht, B.; Lau, S.; Larenas-Linnemann, D.; Laune, D.; Le, L. T. T.; Lieberman, P.; Lipworth, B.; Li, J.; Louis, R.; Magard, Y.; Magnan, A.; Mahboub, B.; Majer, I.; Makela, M. J.; Manning, P.; De Manuel Keenoy, E.; Marshall, G. D.; Masjedi, M. R.; Maurer, M.; Mavale-Manuel, S.; Melen, E.; Melo-Gomes, E.; Meltzer, E. O.; Merk, H.; Miculinic, N.; Mihaltan, F.; Milenkovic, B.; Mohammad, Y.; Molimard, M.; Momas, I.; Montilla-Santana, A.; Morais-Almeida, M.; Moesges, R.; Namazova-Baranova, L.; Naclerio, R.; Neou, A.; Neffen, H.; Nekam, K.; Niggemann, B.; Nyembue, T. D.; O'Hehir, R. E.; Ohta, K.; Okamoto, Y.; Okubo, K.; Ouedraogo, S.; Paggiaro, P.; Pali-Schoell, I.; Palmer, S.; Panzner, P.; Papi, A.; Park, H. S.; Pavord, I.; Pawankar, R.; Pfaar, O.; Picard, R.; Pigearias, B.; Pin, I.; Plavec, D.; Pohl, W.; Popov, T. A.; Portejoie, F.; Postma, D.; Potter, P.; Price, D.; Rabe, K. F.; Raciborski, F.; Pontal, F. Radier; Repka-Ramirez, S.; Robalo-Cordeiro, C.; Rolland, C.; Rosado-Pinto, J.; Reitamo, S.; Rodenas, F.; Roman Rodriguez, M.; Romano, A.; Rosario, N.; Rosenwasser, L.; Rottem, M.; Sanchez-Borges, M.; Scadding, G. K.; Serrano, E.; Schmid-Grendelmeier, P.; Sheikh, A.; Simons, F. E. R.; Sisul, J. C.; Skrindo, I.; Smit, H. A.; Sole, D.; Sooronbaev, T.; Spranger, O.; Stelmach, R.; Strandberg, T.; Sunyer, J.; Thijs, C.; Todo-Bom, A.; Triggiani, M.; Valenta, R.; Valero, A. L.; van Hage, M.; Vandenplas, O.; Vezzani, G.; Vichyanond, P.; Viegi, G.; Wagenmann, M.; Walker, S.; Wang, D. Y.; Wahn, U.; Williams, D. M.; Wright, J.; Yawn, B. P.; Yiallouros, P. K.; Yusuf, O. M.; Zar, H. J.; Zernotti, M. E.; Zhang, L.; Zhong, N.; Zidarn, M.; Mercier, J.

    2015-01-01

    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient e

  7. Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study

    OpenAIRE

    Luukkainen Annika; Karjalainen Jussi; Honkanen Teemu; Lehtonen Mikko; Paavonen Timo; Toppila-Salmi Sanna

    2011-01-01

    Abstract Background Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. Objective Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis patients allergic to birch pollen during peak exposure to birch pollen allergen and compare it to non-atopic patients. Methods IDO expression was immunohistochemically e...

  8. The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression.

    Directory of Open Access Journals (Sweden)

    Ariane H Wagener

    Full Text Available BACKGROUND: The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. OBJECTIVE: Defining gene expression profiles of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. METHODS: This cross-sectional study included 18 subjects (6 allergic asthma and allergic rhinitis; 6 allergic rhinitis; 6 healthy controls. The estimated false discovery rate comparing 6 subjects per group was approximately 5%. RNA was extracted from isolated and cultured epithelial cells from bronchial brushings and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array. Data were analysed using R and Bioconductor Limma package. For gene ontology GeneSpring GX12 was used. RESULTS: The study was successfully completed by 17 subjects (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls. Using correction for multiple testing, 1988 genes were differentially expressed between healthy lower and upper airway epithelium, whereas in allergic rhinitis with or without asthma this was only 40 and 301 genes, respectively. Genes influenced by allergic rhinitis with or without asthma were linked to lung development, remodeling, regulation of peptidases and normal epithelial barrier functions. CONCLUSIONS: Differences in epithelial gene expression between the upper and lower airway epithelium, as observed in healthy subjects, largely disappear in patients with allergic rhinitis with or without asthma, whilst new differences emerge. The present data identify several pathways and genes that might be

  9. Allergic sensitization to ornamental plants in patients with allergic rhinitis and asthma.

    Science.gov (United States)

    Aydin, Ömür; Erkekol, Ferda Öner; Misirloigil, Zeynep; Demirel, Yavuz Selim; Mungan, Dilşad

    2014-01-01

    Ornamental plants (OPs) can lead to immediate-type sensitization and even asthma and rhinitis symptoms in some cases. This study aimed to evaluate sensitization to OPs in patients with asthma and/or allergic rhinitis and to determine the factors affecting the rate of sensitization to OPs. A total of 150 patients with asthma and/or allergic rhinitis and 20 healthy controls were enrolled in the study. Demographics and disease characteristics were recorded. Skin-prick tests were performed with a standardized inhalant allergen panel. Skin tests by "prick-to-prick" method with the leaves of 15 Ops, which are known to lead to allergenic sensitization, were performed. Skin tests with OPs were positive in 80 patients (47.1%). There was no significant difference between OP sensitized and nonsensitized patients in terms of gender, age, number of exposed OPs, and duration of exposure. Skin test positivity rate for OPs was significantly high in atopic subjects, patients with allergic rhinitis, food sensitivity, and indoor OP exposure, but not in patients with pollen and latex allergy. Most sensitizing OPs were Yucca elephantipes (52.5%), Dieffenbachia picta (50.8%), and Euphorbia pulcherrima (47.5%). There was significant correlation between having Saintpaulia ionantha, Croton, Pelargonium, Y. elephantipes, and positive skin test to these plants. Sensitivity to OPs was significantly higher in atopic subjects and patients with allergic rhinitis, food allergy, and indoor OP exposure. Furthermore, atopy and food sensitivity were found as risk factors for developing sensitization to indoor plants. Additional trials on the relationship between sensitization to OPs and allergic symptoms are needed. PMID:24717779

  10. The effects of two Chinese herbal medicinal formulae vs. placebo controls for treatment of allergic rhinitis: a randomised controlled trial

    OpenAIRE

    Chan, Rose YP; Chien, Wai Tong

    2014-01-01

    Background Allergic rhinitis is a chronic illness, affecting 10 to 40% of the worldwide population. Chinese herbal medicines, the treatment of allergic rhinitis, adopted thousands of years in ancient China, has recently raised much attention among researchers globally. This study evaluates the effects of two Chinese herbal formulae [Cure-allergic-rhinitis Syrup (CS) and Yu-ping-feng San (YS)] in treating undergraduate nursing students with allergic rhinitis over a 3-month follow-up, when comp...

  11. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation.

    Science.gov (United States)

    Bousquet, J; Schunemann, H J; Fonseca, J; Samolinski, B; Bachert, C; Canonica, G W; Casale, T; Cruz, A A; Demoly, P; Hellings, P; Valiulis, A; Wickman, M; Zuberbier, T; Bosnic-Anticevitch, S; Bedbrook, A; Bergmann, K C; Caimmi, D; Dahl, R; Fokkens, W J; Grisle, I; Lodrup Carlsen, K; Mullol, J; Muraro, A; Palkonen, S; Papadopoulos, N; Passalacqua, G; Ryan, D; Valovirta, E; Yorgancioglu, A; Aberer, W; Agache, I; Adachi, M; Akdis, C A; Akdis, M; Annesi-Maesano, I; Ansotegui, I J; Anto, J M; Arnavielhe, S; Arshad, H; Baiardini, I; Baigenzhin, A K; Barbara, C; Bateman, E D; Beghé, B; Bel, E H; Ben Kheder, A; Bennoor, K S; Benson, M; Bewick, M; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Boner, A L; Boulet, L P; Bonini, M; Bonini, S; Bosse, I; Bourret, R; Bousquet, P J; Braido, F; Briggs, A H; Brightling, C E; Brozek, J; Buhl, R; Burney, P G; Bush, A; Caballero-Fonseca, F; Calderon, M A; Camargos, P A M; Camuzat, T; Carlsen, K H; Carr, W; Cepeda Sarabia, A M; Chavannes, N H; Chatzi, L; Chen, Y Z; Chiron, R; Chkhartishvili, E; Chuchalin, A G; Ciprandi, G; Cirule, I; Correia de Sousa, J; Cox, L; Crooks, G; Costa, D J; Custovic, A; Dahlen, S E; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; Denburg, J A; Devillier, P; Didier, A; Dinh-Xuan, A T; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, S R; Dykewicz, M S; El-Gamal, Y; Emuzyte, R; Fink Wagner, A; Fletcher, M; Fiocchi, A; Forastiere, F; Gamkrelidze, A; Gemicioğlu, B; Gereda, J E; González Diaz, S; Gotua, M; Grouse, L; Guzmán, M A; Haahtela, T; Hellquist-Dahl, B; Heinrich, J; Horak, F; Hourihane, J O 'b; Howarth, P; Humbert, M; Hyland, M E; Ivancevich, J C; Jares, E J; Johnston, S L; Joos, G; Jonquet, O; Jung, K S; Just, J; Kaidashev, I; Kalayci, O; Kalyoncu, A F; Keil, T; Keith, P K; Khaltaev, N; Klimek, L; Koffi N'Goran, B; Kolek, V; Koppelman, G H; Kowalski, M L; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, L T T; Lieberman, P; Lipworth, B; Li, J; Louis, R; Magard, Y; Magnan, A; Mahboub, B; Majer, I; Makela, M J; Manning, P; De Manuel Keenoy, E; Marshall, G D; Masjedi, M R; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, E O; Merk, H; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, Y; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Mösges, R; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Nyembue, T D; O'Hehir, R E; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Palmer, S; Panzner, P; Papi, A; Park, H S; Pavord, I; Pawankar, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, T A; Portejoie, F; Postma, D; Potter, P; Price, D; Rabe, K F; Raciborski, F; Radier Pontal, F; Repka-Ramirez, S; Robalo-Cordeiro, C; Rolland, C; Rosado-Pinto, J; Reitamo, S; Rodenas, F; Roman Rodriguez, M; Romano, A; Rosario, N; Rosenwasser, L; Rottem, M; Sanchez-Borges, M; Scadding, G K; Serrano, E; Schmid-Grendelmeier, P; Sheikh, A; Simons, F E R; Sisul, J C; Skrindo, I; Smit, H A; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Strandberg, T; Sunyer, J; Thijs, C; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, A L; van Hage, M; Vandenplas, O; Vezzani, G; Vichyanond, P; Viegi, G; Wagenmann, M; Walker, S; Wang, D Y; Wahn, U; Williams, D M; Wright, J; Yawn, B P; Yiallouros, P K; Yusuf, O M; Zar, H J; Zernotti, M E; Zhang, L; Zhong, N; Zidarn, M; Mercier, J

    2015-11-01

    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards. PMID:26148220

  12. Allergic rhinitis is often un-diagnosed and un-treated

    DEFF Research Database (Denmark)

    Larsen, Christian Grønhøj; Gyldenløve, Mette; Linneberg, Allan

    2013-01-01

    INTRODUCTION: A few earlier studies have indicated that allergic rhinitis (AR) is under-diagnosed and under-treated. OBJECTIVE: To assess awareness, diagnosis and treatment of allergic rhinitis in a general population of Danish adults. METHODS: Between October 2007 and June 2008, a total of 1277...

  13. Control of Allergic Rhinitis and Asthma Test (CARAT) : dissemination and applications in primary care

    NARCIS (Netherlands)

    Azevedo, Pedro; Correia-de-Sousa, Jaime; Bousquet, Jean; Bugalho-Almeida, Antonio; Del Giacco, Stefano R.; Demoly, Pascal; Haahtela, Tari; Jacinto, Tiago; Garcia-Larsen, Vanessa; van der Molen, Thys; Morais-Almeida, Mario; Nogueira-Silva, Luis; Pereira, Ana M.; Roman-Rodrigues, Miguel; Silva, Barbara G.; Tsiligianni, Ioanna G.; Yaman, Hakan; Yawn, Barbara; Fonseca, Joao A.

    2013-01-01

    Asthma frequently occurs in association with allergic rhinitis and a combined management approach has been suggested. The Control of Allergic Rhinitis and Asthma Test (CARAT) is the first questionnaire to assess control of both diseases concurrently. However, to have an impact on healthcare it needs

  14. The long-term results of the impact of rhinophototherapy on quality of life in cases with allergic rhinitis

    OpenAIRE

    Yaz, Aytekin; Cingi, Cemal; Gürbüz, Melek Kezban; BAL, CENGIZ

    2012-01-01

    Objective: In this study the effects of intranasal rhinophototherapy on symptoms of allergic rhinitis, physical examination findings, and quality of life of our patients with allergic rhinitis have been investigated. Methods: Our study group consisted of the patients followed up for at least 2 years with diagnosis of allergic rhinitis in our outpatient clinic. Among them the first 100 patients who underwent nasal phototherapy ...

  15. Radioactive Merano SPA Treatment for Allergic Rhinitis Therapy

    Directory of Open Access Journals (Sweden)

    Desiderio Passali

    2016-01-01

    Full Text Available Allergic rhinitis is a common nasal disorder with a high impact on quality of life, high social costs in therapies, and a natural development towards asthma. Pharmacological therapy is based on several genres of medications, of which intranasal corticosteroids are currently the most widespread. Thermal water treatment has traditionally been used as adjunctive treatment for chronic rhinitis and sinusitis. The present study was carried out to assess the clinical efficacy of nasal inhalation of radioactive oligomineral water vapours from the Merano hot spring and to compare it with the clinical efficacy of mometasone furoate nasal spray. A comparative prospective study was performed in 90 allergic patients treated at Merano hot springs: a group of 54 subjects treated with radioactive thermal oligomineral water and a control group of 36 subjects treated with mometasone nasal spray. Patients of both groups were assessed before and after treatment by Sino-Nasal Outcome Test questionnaire, active anterior rhinomanometry with flow and resistance monitoring, measurement of mucociliary transport time, and cytological examination of nasal brushing/scraping. The study showed that inhalation treatment with radioactive hydrofluoric thermal water for two weeks produces an objective clinical and cytological improvement in allergic patients, similar to that obtained with mometasone furoate nasal spray.

  16. Radioactive Merano SPA Treatment for Allergic Rhinitis Therapy

    Science.gov (United States)

    Gabelli, Giacomo; Passali, Giulio Cesare; Magnato, Roberto; Platzgummer, Stefan; Salerni, Lorenzo; Lo Cunsolo, Salvatore; Joos, Alexandra; Bellussi, Luisa Maria

    2016-01-01

    Allergic rhinitis is a common nasal disorder with a high impact on quality of life, high social costs in therapies, and a natural development towards asthma. Pharmacological therapy is based on several genres of medications, of which intranasal corticosteroids are currently the most widespread. Thermal water treatment has traditionally been used as adjunctive treatment for chronic rhinitis and sinusitis. The present study was carried out to assess the clinical efficacy of nasal inhalation of radioactive oligomineral water vapours from the Merano hot spring and to compare it with the clinical efficacy of mometasone furoate nasal spray. A comparative prospective study was performed in 90 allergic patients treated at Merano hot springs: a group of 54 subjects treated with radioactive thermal oligomineral water and a control group of 36 subjects treated with mometasone nasal spray. Patients of both groups were assessed before and after treatment by Sino-Nasal Outcome Test questionnaire, active anterior rhinomanometry with flow and resistance monitoring, measurement of mucociliary transport time, and cytological examination of nasal brushing/scraping. The study showed that inhalation treatment with radioactive hydrofluoric thermal water for two weeks produces an objective clinical and cytological improvement in allergic patients, similar to that obtained with mometasone furoate nasal spray.

  17. Exercise induced changes in spirometry and impulse oscillometry measurements in persistent allergic rhinitis.

    OpenAIRE

    2012-01-01

    The Link between allergic rhinitis and asthma is well known. Bronchial hyperreactivity (BHR) may be present in rhinitis. The present study was aimed to compare airway responses in patients  with rhinitis symptoms alone following exercise challenge, and to  determine relationship of two different respiratory function tests.98 subjects with rhinitis were investigated by spirometry and impulse oscillometry before and after exercise challenge.No  significant difference was detected  between spiro...

  18. Treating allergic rhinitis by sublingual immunotherapy: a review

    Directory of Open Access Journals (Sweden)

    Cristoforo Incorvaia

    2012-06-01

    Full Text Available OBJECTIVE: Allergic rhinitis (AR is a disease with high and increasing prevalence. The management of AR includes allergen avoidance, anti-allergic drugs, and allergen specific immunotherapy (AIT, but only the latter works on the causes of allergy and, due to its mechanisms of action, modifies the natural history of the disease. Sublingual immunotherapy (SLIT was proposed in the 1990s as an option to traditional, subcutaneous immunotherapy. MATERIAL AND METHODS: We reviewed all the available controlled trials on the efficacy and safety of SLIT. RESULTS AND CONCLUSION: Thus far, more than 60 trials, globally evaluated in 6 meta-analyses, showed that SLIT is an effective and safe treatment for AR. However, it must be noted that to expect clinical efficacy in the current practice SLIT has to be performed following the indications from controlled trials, that is, sufficiently high doses to be regularly administered for at least 3 consecutive years.

  19. Role of Crosstalk between Epithelial and Immune Cells, the Epimmunome, in Allergic Rhinitis Pathogenesis.

    Science.gov (United States)

    Kamekura, Ryuta; Yamashita, Keiji; Jitsukawa, Sumito; Nagaya, Tomonori; Ito, Fumie; Ichimiya, Shingo; Himi, Tetsuo

    2016-01-01

    Recently, the prevalence of allergic rhinitis has been dramatically increasing worldwide. As conventional therapies for allergic rhinitis, such as antihistamines, leukotriene receptor antagonists, nasal sprays and allergen immunotherapy, have limitations, the development of new drugs is required. Recent studies have revealed that epithelial cell-derived cytokines, including thymic stromal lymphopoietin, interleukin (IL)-25 and IL-33, are able to control immune cells, such as dendritic cells and T cells, thereby acting as 'master switches' in allergic disease. In addition, new roles have been identified for follicular helper T cells and regulatory B cells in allergic disease, and they are considered to be promising targets for new therapies. Thus, crosstalk between epithelial and immune cells, the epimmunome, underlies the pathogenesis of allergic rhinitis. Greater understanding of the epimmunome may lead to breakthroughs in the development of new treatments for allergic rhinitis and will help us cure many patients suffering from its severe symptoms in the future. PMID:27116609

  20. Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

    OpenAIRE

    Nilsson Daniel; Andiappan Anand; Halldén Christer; Yun Wang; Säll Torbjörn; Tim Chew; Cardell Lars-Olaf

    2012-01-01

    Abstract Background The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes. Methods A first association analysis genotyped 73 SNPs in 182 case...

  1. Tian Jiu therapy for allergic rhinitis: study protocol for a randomized controlled trial

    OpenAIRE

    Kun, Wai; Zhong, Linda L.D.; Dai, Liang; Cheng, Chung-Wah; Lu, Ai-Ping; Bian, Zhao-Xiang

    2016-01-01

    Background Allergic rhinitis (AR) is one of the most common allergic diseases. The conventional treatments of allergic rhinitis are oral anti-histamines, the use of intranasal corticosteroids, and immunotherapy. Dissatisfied with the ineffectiveness and side effects of these treatments, substantial numbers of patients are turning to alternative treatments like Chinese herbal medicine, particularly Tian Jiu (TJ). TJ is a form of moxibustion in which herbal patches are applied to specific acupo...

  2. Treatment Evaluation with Mometasone Furoate, Alone or in Combination with Desloratadine/ Montelukast in Moderate Severe Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Florincescu-Gheorghe Nona-Aura

    2014-06-01

    Full Text Available Introduction: Allergic rhinitis is one of the most common allergic diseases, characterized by the inflammation of the nasal mucosa. Eosinophils play a predominant pro-inflammatory role in allergic inflammation. This study assesses the effect of mometasone furoate alone or in combination with desloratadine/montelukast in patients with moderate-severe allergic rhinitis.

  3. Responses of Six-Weeks Aquatic Exercise on the Autonomic Nervous System, Peak Nasal Inspiratory Flow and Lung Functions in Young Adults with Allergic Rhinitis

    OpenAIRE

    Taweesak Janyacharoen; Narupon Kunbootsri; Preeda Arayawichanon; Seksun Chainansamit; Kittisak Sawanyawisuth

    2015-01-01

    Allergic rhinitis is a chronic respiratory disease. Sympathetic hypofunction is identified in all of the allergic rhinitis patients. Moreover, allergic rhinitis is associated with decreased peak nasal inspiratory flow (PNIF) and impaired lung functions. The aim of this study was to investigate effects of six-week of aquatic exercise on the autonomic nervous system function, PNIF and lung functions in allergic rhinitis patients.Twenty-six allergic rhinitis patients, 12 males and 14 females wer...

  4. Clinical features of allergic rhinitis in children of Shanghai, China.

    Science.gov (United States)

    He, S; Li, Y J; Chen, J

    2016-01-01

    The aims of the current study were to assess the clinical features of allergic rhinitis (AR) in children in Shanghai. Serum-specific IgE (sIgE) tests were performed on samples from patients with AR symptoms from January 2011 to December 2014. A disease-related questionnaire was completed after AR diagnosis. The allergen profile and clinical features of AR were analyzed. In total, 2713 AR patients were enrolled in this study. Dermatophagoides pteronyssinus was found to be the most common offending allergen in the study population. With increasing age, the prevalence of sIgE against inhalant allergens was significantly increased; however, the opposite trend was observed for food allergens. Additionally, the proportion of children with high levels of sIgE against D. pteronyssinus increased with age. Of the AR cases, 8.6% were classified as intermittent mild, 4.2% as persistent mild, 40.5% as intermittent moderate-severe, and 46.7% as persistent moderate-severe. A family history of allergies and a patient history of allergies within 6 months of birth were significantly associated with the duration and severity of AR symptoms. The occurrence of co-morbidities, such as allergic conjunctivitis, cough, and asthma, gradually increased from intermittent mild, persistent mild, and intermittent moderate-severe to persistent moderate-severe. The most frequently used drugs were topical corticosteroids and oral antihistamines, which were used by 86.7 and 79.0% of patients, respectively. These results confirm the adequacy of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines for classifying AR patients, and advance the understanding of clinical features of AR in children in Shanghai, China. PMID:27173334

  5. Pathogenesis of allergic rhinitis.%变应性鼻炎的发病机制

    Institute of Scientific and Technical Information of China (English)

    魏欣

    2011-01-01

    Allergic Rhinitis is a common disease ofotolar ngology. Its pathogenesis is not clear and the treatmerit effect is not satisfied. This article has reviewed the pathogenesis of allergic Rhinitis by heredity, environment and Immunology.%变应性鼻炎(Allergic rhinitis,AR)是耳鼻咽喉科的常见病,发病机制尚不完全清楚,临床治疗仍不能完全令人满意,本文从遗传、环境及免疫学角度就变应性鼻炎的发病机制做一综述.

  6. p38 MAPK Regulates Th2 Cytokines Release in PBMCs in Allergic Rhinitis Rats

    Institute of Scientific and Technical Information of China (English)

    刘杰; 刘立思; 崔永华; 张剑; 江红群

    2010-01-01

    Th2 cytokines play a pivotal role in the pathogenesis of allergic rhinitis.To investigate the effect of p38 mitogen-activated protein kinase(MAPK) on the production of Th2 cytokines such as IL-4 and IL-5 in allergic rhinitis,a model of allergic rhinitis was established in SD rats.The expression level of p38 MAPK mRNA in PBMCs was detected by means of real time quantitative RT-PCR.The p38 MAPK activity in PBMCs was detected by Western blotting.PBMCs were cultured with various concentrations of p38 MAPK inhib...

  7. The Evaluation of Thyroid Function Disorders in Patients with Allergic Rhinitis

    OpenAIRE

    Ayse Akkoca

    2014-01-01

    Aim: In this study, we aimed to determine the ratio of thyroid hormone disorders in subjects with allergic rhinitis and investigate the association between these two diseases. Material and Method: 62 patients who presented with symptoms of allergic rhinitis and have positive skin prick test and 62 patients as a control group were included in the study to examine thyroid hormone disorders. Results: Mean age of patients with allergic rhinitis were 43.20 ± 18.55. 54.4% of the patients were femal...

  8. A CROSS SECTIONAL STUDY OF BRONCHIAL ASTHMA IN ALLERGIC RHINITIS PATIENTS: A COMMUNITY BASED ASSESSMENTS AMONG ADULTS IN BANGALORE

    Directory of Open Access Journals (Sweden)

    Giriraja

    2015-12-01

    Full Text Available BACKGROUND Allergic rhinitis is rather erroneously viewed as a trivial disease, it is important to note that it can significantly affect the quality of life. There is significant overlap between bronchial asthma and allergic rhinitis. AIMS This study was done to assess the prevalence of asthmatics in allergic rhinitis patients. MATERIALS AND METHODS A community based cross sectional study was conducted in Bangalore, among 1000 adults aged 30 yrs and above. Allergic rhinitis was diagnosed as per ARIA guidelines. Sperometery was done to diagnose asthma among them. Multivariate logistic regression analysis has been used to find the association of risk factors with disease. RESULTS Among subjects with allergic rhinitis, 40(33% were also diagnosed to be suffering from concomitant asthma showing a considerable overlap between rhinitis and asthma. CONCLUSION Burden of allergic rhinitis is high with a considerable overlap with asthma. This highlights the importance of early and regular treatment

  9. Association between Allergic Rhinitis and Asthma Control in Peruvian School Children: A Cross-Sectional Study

    Directory of Open Access Journals (Sweden)

    Justo Padilla

    2013-01-01

    Full Text Available Background. Asthma and allergic rhinitis are highly prevalent conditions that cause major illness worldwide. This study aimed to assess the association between allergic rhinitis and asthma control in Peruvian school children. Methods. A cross-sectional study was conducted among 256 children with asthma recruited in 5 schools from Lima and Callao cities. The outcome was asthma control assessed by the asthma control test. A score test for trend of odds was used to evaluate the association between allergic rhinitis severity and the prevalence of inadequate asthma control. A generalized linear regression model was used to estimate the adjusted prevalence ratios of inadequate asthma control. Results. Allergic rhinitis was present in 66.4% of the population with asthma. The trend analysis showed a positive association between allergic rhinitis and the probability of inadequate asthma control (. It was associated with an increased prevalence of inadequate asthma control, with adjusted prevalence ratios of 1.53 (95% confidence interval: 1.19−1.98. Conclusion. This study indicates that allergic rhinitis is associated with an inadequate level of asthma control, giving support to the recommendation of evaluating rhinitis to improve asthma control in children.

  10. Does allergic rhinitis affect communication skills in young adults?

    Science.gov (United States)

    Cingi, Can Cemal; Sakallıoğlu, Öner; Muluk, Nuray Bayar; Cingi, Cemal

    2016-01-01

    Allergic rhinitis (AR) is a chronic disorder with a high prevalence in the general population. The symptoms of AR can impair the cognitive capabilities of the affected people. The study of communication skills and AR interaction has not been adequately discussed. We aimed to analyze Social Communication Skills of university students with AR. Fifty patients suffering from AR and 50 healthy subjects were studied. All participants completed two questionnaires [Social Communication Skills Rating Scale (SCSRS) and Communication Questionnaire] for the assessment of social communication skills. Total scores of both SCSRS and Communication Questionnaire were higher in participants with AR than controls. When the questions of SCSRS were compared between the groups one by one, significant difference was observed between the groups for questions numbered 1-9 and 11, 12 (p Communication Questionnaire (p communication skills of the patients with AR. More research is however needed to validate this hypothesis.

  11. Quality of Sexual Life in Males with Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Gul Soylu Ozler

    2014-12-01

    Full Text Available Aim: The aim of this study is to evaluate the quality of sexual life of males with allergic rhinitis(AR. Material and Method: 40 patients with AR diagnosed with skin prick test and 40 control subjects with no evidence of allergy completed the study. International Index of Erectile Function questionnaire (IIEF was used to evaluate the quality of sexual life of the subjects. Results: The mean scores of erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction for AR group were significantly lower than control group(p=0.0001. Discussion: AR has negative effects on quality of life. The effective treatment of AR by the clinician will also avoid these concomitting social, sexual and sleep disturbances.

  12. Determinants of allergic rhinitis in young children with asthma.

    Directory of Open Access Journals (Sweden)

    Lise Moussu

    Full Text Available BACKGROUND: In the preschool period, allergic rhinitis (AR is infrequent and thus under-diagnosed. However, recent works have highlighted the occurrence of AR in toddlers although the causes of AR in this young population remain unknown. The objective of this study was to identify determinants of AR in young children with asthma. METHODS: We carried out a case-control study of 227 children with active asthma and enrolled in the Trousseau Asthma Program. AR and other allergic diseases (asthma, food allergy and eczema were diagnosed by medical doctors using standardized questionnaires. Parental history of AR and asthma, biological markers of atopy (total IgE, blood eosinophilia, allergic sensitization towards food and aeroallergens and environmental parameters were also collected. RESULTS: Forty one of the children (18.1% had AR. By univariate logistic regression analysis, AR was mainly associated with peanut sensitization (OR = 6.75; p = 0.002; food allergy (OR = 4.31; p = 0.026; mold exposure (OR = 3.81 p<0.01 and parental history of AR (OR = 1.42; p = 0.046. Due to the strong link between food allergy and peanut sensitization three models of multivariate logistic regression were performed and confirmed that AR is associated with peanut sensitization but also food allergy and mold exposure. A random forest analysis was also performed to explain AR. The results reinforced the logistic analysis that peanut sensitization and mold exposure were the principal determinants of AR. CONCLUSIONS & CLINICAL RELEVANCE: These results stress the importance of investigating AR in young children with asthma to potentially diagnose a particularly severe allergic asthmatic phenotype. Moreover, these data evoke the hypothesis that peanut could be an aeroallergen.

  13. Comparative study of specific IgE for cockroach between asthma and allergic rhinitis patients

    International Nuclear Information System (INIS)

    To compare the degrees of allergic reaction and the cross-reactive allergens for three strains of cockroach (Periplanceta fuliginosa , Periplaneta americana and Blattella germanica) between patients with asthma and allergic rhinitis, the specific IgE(sIgE) in asthma and allergic rhinitis for these three strains of cockroach were determined with ELISA. The results showed that the sIgE positive rates for Periplaneta americana, Periplaneta fuliginosa and Blattella germanica in patients with asthma were 23.5%, 16.0% and 14.8%, respectively. The reactive coincidence rate between Periplaneta americana and Periplaneta fuliginoas was 74.0%, between Periplaneta americana and Blattella germanica was 73.5%, and between Periplaneta fuliginosa and Blattella germanica was 85.0% in asthma patients. The IgE positive rates for Periplaneta americana, Periplaneta fuliginosa and Blattella gerraanica in allergic rhinitis patients were 24.8%, 17.6% and 15.8%, respectively. The reactive coincidence rate between Periplaneta americana and Periplaneta fuliginosa was 73.9%, between Periplaneta americana and Blattella germanica was 75.2%, and between Periplaneta fuliginosa and Blattella germanica was 86.1% in allergic rhinitis patients. There was no significant difference between asthma and allergic rhinitis patients although the sIgE positive rates of allergic rhinitis patients were higher than those of asthma patients for these three strains of cock- roach. All these results indicated that the degrees of allergic reaction are similar between asthma and allergic rhinitis patients and there are some cross-reactive allergic components among these three strains of cockroach. (authors)

  14. Probiotics and allergic rhinitis%益生菌与变应性疾病

    Institute of Scientific and Technical Information of China (English)

    黄石; 赵宇

    2013-01-01

    The prevalence of allergic diseases has increased in recent years, and primary prevention of allergic disease is considered to be an elusive goal. This paper summarizes the recent publications on probiotics in allergic rhinitis. It focuses on clinical and laboratory observations of treatment or prevention of allergic rhinitis. Probiotics administration represents different outcome, its effects depend on a variety of factors, such as dosing regimen, delivery method and the types of bacterium. Since the data from different research centers are conflicting, the further studies are required.

  15. The Ten Methods Used by Dr.CHEN Guo-feng for Treating Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    FU Xiao-dong; WANG Xin-zhong

    2010-01-01

    @@ According to the TCM theory, allergic rhinitis is usually caused by dysfunction of the lung, spleen and kidney, deficiency of the vital-qi, and invasion of exopathogenic factors of wind and cold.Dr.CHEN Guo-feng, director of the Ear-Nose-Throat Department of Jiangsu Provincial TCM Hospital, has obtained rich experience in the treatment of allergic rhinitis, which is introduced in the following.

  16. Effects of wheezing in early childhood in the development of allergic rhinitis in later years

    OpenAIRE

    Cetinkaya, Feyzullah; Atalay, Ozgur Ozhan

    2014-01-01

    Background Studies on the long-term effects of wheezing in infancy have particularly focused on asthma. There isn't adequate information about the effects of wheezing in the development of allergic rhinitis in later years. Objective In this study, children with wheezing in the first year of life were investigated in terms of allergic rhinitis after five years of age. Methods The study consisted of children with early-transient wheezing or persistent wheezing. The study groups were evaluated i...

  17. Prevalence of allergic rhinitis and its associated morbidity in adults with asthma: A multicentre study

    OpenAIRE

    Ko, FWS; Ip, MSM; Chu, CM; So, LKY; Lam, DCL; Hui, DSC

    2010-01-01

    Objectives To assess the prevalence of allergic rhinitis in adult patients with asthma in Hong Kong, and to compare the morbidity endured by asthma patients with and without allergic rhinitis. Design Cross-sectional study. Setting Respiratory clinics of four major public hospitals in Hong Kong. Patients A total of 600 adults with asthma were recruited from March to May 2007. Main outcome measures Doctors and patients completed separate questionnaires evaluating symptoms, treatment, and health...

  18. Understanding the role of the healthcare professional in patient self-management of allergic rhinitis

    OpenAIRE

    Kuehl, Bonnie L; Abdulnour, Shahad; O’Dell, Michael; Kyle, Theodore K

    2015-01-01

    Objective: Allergic rhinitis is a common, usually long-standing, condition that may be self-diagnosed or have a formal diagnosis. Our aim was to identify how allergic rhinitis sufferers self-manage their condition. Methods: A sample of 276 self-identified adult allergy sufferers pooled from social media completed an online survey comprising 13 questions. The survey was fielded by a professional research organization (Lab42). The main outcome measures included the use of prescription and/or no...

  19. Inhibition of histamine-induced nasal obstruction by cetirizine in allergic rhinitis.

    OpenAIRE

    Braunstein, G; Malaquin, F; Fajac, I; Melac, M; Frossard, N

    1992-01-01

    This double-blind randomized crossover placebo-controlled study was designed to assess objectively the nasal antihistamine effect of cetirizine in patients with allergic rhinitis and control subjects. Nasal challenge was performed by nebulization of increasing doubling doses of histamine (0; 0.04 to 1.28 mg/nostril) in six patients with allergic rhinitis and six control subjects on cetirizine (2 x 10 mg daily for 3 days) or placebo. Sneezings were counted and nasal obstruction was assessed by...

  20. Serum IL-17 & eotaxin levels in asthmatic patients with allergic rhinitis

    OpenAIRE

    Lv, Hong; Lu, Bing; Qian, Xing-jia; Huang, Jian-An; Qiu, Tie-feng

    2016-01-01

    Objective: To investigate the serum levels of Interleukin (IL)-17 and eotaxin levels and the relationship between serum IL-17, eotaxin and pulmonary function in asthmatic patients with allergic rhinitis. Methods: Serum IL-17 and eotaxin levels in asthmatic patients with allergic rhinitis during attacking and remission and in healthy control subjects were measured using enzyme-linked immunosorbent assay (ELISA) kits. Then we studied the correlation between the serum IL-17, eotaxin levels and p...

  1. MACVIA Clinical Decision Algorithm in Allergic Rhinitis in adolescents and adults

    OpenAIRE

    Bousquet, Jean; Schünemann, Holger J.; Hellings, Peter W.; Arnavielhe, Sylvie; Bachert, Claus; Bedbrook, Anna; Bergmann, Karl-Christian; Bosnic-Anticevich, Sinthia; Brozek, Jan; Calderon, Moises; Canonica, G. Walter; Casale, Thomas B.; Chavannes, Niels H; Cox, Linda; Chrystyn, Henry

    2016-01-01

    International audience The selection of pharmacotherapy for patients with allergic rhinitis depends on several factors, including age, prominent symptoms, symptom severity, control of allergic rhinitis, patient preferences and cost. Allergen exposure and resulting symptoms vary and treatment adjustment is required. Clinical decision support systems (CDSS) may be beneficial for the assessment of disease control. Clinical decision support systems should be based on the best evidence and algo...

  2. Association between Allergic Rhinitis and Asthma Control in Peruvian School Children: A Cross-Sectional Study

    OpenAIRE

    Justo Padilla; Mónica Uceda; Otto Ziegler; Felipe Lindo; Eder Herrera-Pérez; Luis Huicho

    2013-01-01

    Background. Asthma and allergic rhinitis are highly prevalent conditions that cause major illness worldwide. This study aimed to assess the association between allergic rhinitis and asthma control in Peruvian school children. Methods. A cross-sectional study was conducted among 256 children with asthma recruited in 5 schools from Lima and Callao cities. The outcome was asthma control assessed by the asthma control test. A score test for trend of odds was used to evaluate the association betwe...

  3. Evidence of an association between the O blood group and allergic rhinitis

    OpenAIRE

    Nelson Falsarella; Ana Iara da Costa Ferreira; Fabiana Nakashima; Cinara de Cássia Brandão de Mattos; Luiz Carlos de Mattos

    2011-01-01

    OBJECTIVE: The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis. METHODS: 168 patients with allergic rhinitis and 168 control individuals from the same geographical region and paired by gender and age were enrolled in the study. ABO phenotypes were identified in red blood cells using the hemagglutination technique. The Fisher exact and chi-squared tests were employed to compare proportions. Statistical significance was set for an alpha error of 5% (p-val...

  4. Control of Allergic Rhinitis and Asthma Test (CARAT): dissemination and applications in primary care

    OpenAIRE

    Azevedo, P.; Correia de Sousa, J; Bousquet, J; Bugalho-Almeida, A; Del Giacco, SR; Demoly, P; Haahtela, T; Jacinto, T; Garcia-Larsen, V; Molen, T. van der; Morais-Almeida, M; Nogueira-Silva, L; Pereira, AM; Rodríguez; Silva, BG

    2013-01-01

    Asthma frequently occurs in association with allergic rhinitis and a combined management approach has been suggested. The Control of Allergic Rhinitis and Asthma Test (CARAT) is the first questionnaire to assess control of both diseases concurrently. However, to have an impact on healthcare it needs to be disseminated and adopted. In this paper we discuss the dissemination of CARAT in different countries and its possible applications in primary care. At present, the adaptation of CARAT for us...

  5. Prevalence and triggers of allergic rhinitis in the United Arab Emirates

    OpenAIRE

    Mahboub, Bassam; Al-Hammadi, Suleiman; Prakash, Vijayshree P; Sulaiman, Nabil; Blaiss, Michael S; Redha, Abdulla Al; Vats, Deepa M

    2014-01-01

    Background and objectives Allergic rhinitis is a morbid condition that is frequently overlooked by patients and physicians. This type of atopy has not been adequately investigated in the United Arab Emirates. Methods This cross-sectional, population-based observational study was conducted in the seven Emirates (Abu Dhabi, Dubai, Sharjah, Ajman, Umm Al-Quwain, Ras Al-Khaimah, and Fujairah). It used the European Community Respiratory Health Survey (ECRHS II) to screen for allergic rhinitis in p...

  6. Allergic rhinitis in northern vietnam: increased risk of urban living according to a large population survey

    Directory of Open Access Journals (Sweden)

    Lâm Hoàng

    2011-08-01

    Full Text Available Abstract Background Little is known about prevalence and risk factors of allergic rhinitis and chronic nasal symptoms among adults in Vietnam. We aimed to estimate the prevalence, risk factor patterns and co-morbidities of allergic rhinitis and chronic nasal symptoms in one urban and one rural area in northern Vietnam. Methods A cross-sectional questionnaire survey was conducted from August 2007 to January 2008 in urban Hoankiem and rural Bavi in Hanoi among adults aged 21-70 years. Of 7008 randomly selected subjects, 91.7% participated in Bavi and 70.3% in Hoankiem. Results Allergic rhinitis ever or chronic nasal symptoms were reported by 50.2%. The prevalence of allergic rhinitis ever was considerably higher in Hoankiem compared to Bavi, 29.6% vs 10.0% (p Conclusions Allergic rhinitis ever was considerably more common in the urban area. Nasal blocking and runny nose was each reported by about one third of the studied sample with no major urban-rural difference. Further, exposure to air pollution at work was significantly associated with allergic rhinitis ever, nasal blocking and runny nose.

  7. Google unveils a glimpse of allergic rhinitis in the real world.

    Science.gov (United States)

    Kang, M-G; Song, W-J; Choi, S; Kim, H; Ha, H; Kim, S-H; Cho, S-H; Min, K-U; Yoon, S; Chang, Y-S

    2015-01-01

    Google Trends (GT) is a Web-based surveillance tool used to explore the searching trends of specific queries on Google. Recent studies have suggested the utility of GT in predicting outbreaks of influenza and other diseases. However, this utility has not been thoroughly evaluated for allergic diseases. Therefore, we investigated the utility of GT for predicting the epidemiology of allergic rhinitis. In the USA, GT for allergic rhinitis showed repetitive seasonality that peaked in late April and early May and then rapidly decreased, and a second small peak occurred in September. These trends are highly correlated with the searching trends for other queries such as 'pollen count', antihistamines such as loratadine and cetirizine (all r > 0.88 and all P Google Trends for allergic rhinitis was similar to the monthly changes in rhinitis symptoms according to the US National Health and Nutrition Examination Survey III, sales for Claritin(®) and all over-the-counter antihistamines, and the number of monthly page views of 'claritin.com'. In conclusion, GT closely reflects the real-world epidemiology of allergic rhinitis in the USA and could potentially be used as a monitoring tool for allergic rhinitis.

  8. THE ROLE OF ALLERGIC RHINITIS IN THE DEVELOPMENT OF OTITIS MEDIA WITH EFFUSION

    Directory of Open Access Journals (Sweden)

    Ranjan Kumar

    2013-03-01

    Full Text Available ABSTRACT: The significant incidence of atopy associated with otitis media with effusion (OME has suggested a role of allergy in the pathogenesis of OME. Past studies implicated allergy in the pathogenesis of otitis media [OM]. Otitis media is a common condition, especially in children. Most episodes of OM were associated with an upper res piratory viral infection and are short- lived and self-limiting with or without medical tre atment. However, chronic OM with effusion (OME has significant sequelae, is refractory to mo st medical treatments, and frequently requires surgical intervention. A large body of epid emiologic and mechanistic evidence supports a role for allergic rhinitis [AR] as a risk for OM. To establish the association of allergic rhinitis with otitis media with effusion 100 childr en of age group 5 to14 were taken, 50 children were suffering from otitis media[test group] & 50 we re healthy[control group]. These children were evaluated clinically & a battery of laboratory tests was performed in all children to establish the prevalence of allergic rhinitis in the m. Out of 50 children with otitis media 12 were suffering from allergic rhinitis & out of 50 health y children 3 were suffering from allergic rhinitis. Chi-square test was performed and the 'P0. 05' value was found to be 0.0127[uncorrected] and was highly significant. The se findings indicate that prevalence of allergic rhinitis is more in persons suffering from OME as compared to healthy individuals

  9. Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study

    Directory of Open Access Journals (Sweden)

    Luukkainen Annika

    2011-12-01

    Full Text Available Abstract Background Indoleamine 2,3-dioxygenase (IDO is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. Objective Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis patients allergic to birch pollen during peak exposure to birch pollen allergen and compare it to non-atopic patients. Methods IDO expression was immunohistochemically evaluated from nasal specimens obtained in- and off-season from otherwise healthy non-smoking volunteers both allergic to birch pollen (having mild or moderate allergic rhinoconjunctivitis and non-allergic controls. Results: The IDO expression levels were low in healthy controls and remained low also in patients allergic to birch pollen. There were no differences in the expression of IDO in- and off-season in either healthy or allergic subjects. Conclusions There is a controversy in the role of IDO in upper and lower airways during allergic airway disease. It seems that IDO is associated to allergic inflammations of the lower airways, but does not have a local role in the nasal cavity at least in mild or moderate forms of allergic rhinitis.

  10. Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients

    Directory of Open Access Journals (Sweden)

    Zhao Changqing

    2011-07-01

    Full Text Available Abstract Background The association between sensitizations and severity of allergic diseases is controversial. Objective This study was to investigate the association between severity of asthma and rhinitis and degree of specific allergic sensitization in allergic patients in China. Method A cross-sectional survey was performed in 6304 patients with asthma and/or rhinitis from 4 regions of China. Patients completed a standardized questionnaire documenting their respiratory and allergic symptoms, their impact on sleep, daily activities, school and work. They also underwent skin prick tests with 13 common aeroallergens. Among the recruited subjects, 2268 provided blood samples for serum measurement of specific IgE (sIgE against 16 common aeroallergens. Results Significantly higher percentage of patients with moderate-severe intermittent rhinitis were sensitized to outdoor allergens while percentage of patients sensitized to indoor allergens was increased with increasing severity of asthma. Moderate-severe intermittent rhinitis was associated with the skin wheal size and the level of sIgE to Artemisia vulgaris and Ambrosia artemisifolia (p Dermatophagoides (D. pteronyssinus and D. farinae (p Conclusions Artemisia vulgaris and Ambrosia artemisifolia sensitizations are associated with the severity of intermittent rhinitis and D. pteronyssinus and D. farinae sensitizations are associated with increasing severity of asthma in China. Increase in number of allergens the patients are sensitized to may also increase the severity of rhinitis and asthma.

  11. EVALUATING THE EFFICACY OF DIFFERENT MODALITIES OF TREATMENT FOR PERSISTENT MODERATE-SEVERE ALLERGIC RHINITIS: A PROSPECTIVE STUDY

    OpenAIRE

    Koteswar; Sharmila

    2015-01-01

    Allergic rhinitis is the commonest allergy encountered in clinical practice. There are various treatment modalities available for this disease control, but till now there is no definitive treatment which will cure allergic rhinitis completely. OBJECTIVE The aim of our study is to prospectively evaluate the efficacy of different modalities of treating persistent moderate-severe allergic rhinitis. MATERIALS AND METHODS A total of 100 patients both male and fema...

  12. Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa

    OpenAIRE

    Braunstahl, Gert-Jan; Overbeek, Shelley; Fokkens, Wytske; KleinJan, Alex; McEuen, A.R.; Walls, A F; Hoogsteden, Henk; Prins, Jan-Bas

    2001-01-01

    textabstractMast cells and basophils are cells that play an important role in the initiation and control of allergic inflammation in asthma and rhinitis. This study was undertaken to determine the presence and dynamics of mast cells and basophils in the nasal and bronchial mucosa of allergic rhinitis patients after segmental bronchial provocation (SBP). Eight nonasthmatic, grass pollen-allergic rhinitis patients and eight healthy controls were included. Bronchial and nasal biopsies, as well a...

  13. Control of Allergic Rhinitis and Asthma Test (CARAT) can be used to assess individual patients over time

    OpenAIRE

    Fonseca Joao A; Nogueira-Silva Luis; Morais-Almeida Mario; Sa-Sousa Ana; Azevedo Luis F; Ferreira Jose; Branco-Ferreira Manuel; Rodrigues-Alves Rodrigo; Bugalho-Almeida Antonio; Bousquet Jean

    2012-01-01

    Abstract Background The Control of Allergic Rhinitis and Asthma Test (CARAT10) has been proposed as the first tool to implement the Allergic Rhinitis and its Impact on Asthma initiative guidelines in clinical practice. To serve this purpose, it must have adequate properties to assess the control of an individual over time. This study aimed to prospectively assess the test-retest reliability, responsiveness and longitudinal validity of CARAT10. Methods Adults with asthma and allergic rhinitis ...

  14. Clinical outcomes and adverse effect monitoring in allergic rhinitis.

    Science.gov (United States)

    Juniper, Elizabeth F; Ståhl, Elisabeth; Doty, Richard L; Simons, F Estelle R; Allen, David B; Howarth, Peter H

    2005-03-01

    The subjective recording in diary cards of symptoms of itch, sneeze, nose running, and blockage, with the use of a rating scale to indicate the level of severity, is usual for clinical trials in allergic rhinitis. The primary outcome measure is usually a composite score that enables a single total symptoms score endpoint. It is appreciated, however, that rhinitis has a greater effect on the individual than is reflected purely by the recording of anterior nasal symptoms. Nasal obstruction is troublesome and may lead to sleep disturbance in addition to impaired daytime concentration and daytime sleepiness. These impairments affect school and work performance. Individuals with rhinitis find it socially embarrassing to be seen sneezing, sniffing, or blowing their nose. To capture these and other aspects of the disease-specific health-related quality of life, questionnaires such as the Rhinoconjunctivitis Quality of Life Questionnaire have been developed and validated for clinical trial use. The adoption of health-related quality of life questionnaires into clinical trials broadens the information obtained regarding the effect of the therapeutic intervention and helps focus on issues relevant to the individual patient. It must be appreciated that it is not only the disease that may adversely affect health-related quality of life; administered therapy, although intended to be beneficial, may also cause health impairment. Adverse-event monitoring is thus essential in clinical trials. The first-generation H 1 -histamines, because of their effect on central H 1 -receptors, are classically associated with central nervous system (CNS) effects such as sedation. Although this is not always perceived by the patient, it is clearly evident with objective performance testing, and positron emission tomography scanning has directly demonstrated the central H 1 -receptor occupancy. The second-generation H 1 -antihistamines have reduced central H 1 -receptor occupancy and considerably

  15. Treatment of 48 Cases of Perennial Allergic Rhinitis with Thunder-fire Moxibustion

    Institute of Scientific and Technical Information of China (English)

    蒋洁明; 张沈煜

    2010-01-01

    @@ Perennial allergic rhinitis is an allergic reaction of the nasal mucosa.It is characterized by paroxysmal and repeated runny nose,sneeze,stuffy nose,rhinocnesmus and nasal mucosa edema.The author used "Doctor ZHAO's thunder-fire moxibustion" in treating 48 cases of this disease.Now it is reported as follows.

  16. Citizen science based symptom scores of allergic rhinitis to validate the grass pollen hay fever forecast

    NARCIS (Netherlands)

    Weger, L.A.; Bas Hofstee, H.; Vliet, van A.J.H.; Hiemstra, P.S.; Sont, Jacob K.

    2015-01-01

    Introduction: On average 23% of the European population suffers from allergic rhinitis of which pollen is a major cause. Hay fever symptom forecasts can help these patients to adapt their behaviour and to take their medication in time. We developed the LUMC hay fever forecast for grass pollen allerg

  17. Atopic Manifestations: Dermatitis, Allergic Rhinitis and Asthma in Patients With Hypogammaglobulinemia

    OpenAIRE

    Minoo Dadkhah; Asghar Aghamohammadi; Masoud Movahedi; Mohammad Gharagozlou

    2015-01-01

    Background: Most of the hypogammaglobulinemic patients have a clinical history in favor of allergic respiratory disease. Nevertheless, in these patients the importance and prevalence of atopic disorders have not been completely explained. Objectives: This study was aimed to evaluate atopic manifestations (dermatitis, allergic rhinitis and asthma) and pulmonary function in patients with hypogammaglobulinemia. ...

  18. Exercise induced changes in spirometry and impulse oscillometry measurements in persistent allergic rhinitis.

    Directory of Open Access Journals (Sweden)

    Saba Arshi

    2012-09-01

    Full Text Available The Link between allergic rhinitis and asthma is well known. Bronchial hyperreactivity (BHR may be present in rhinitis. The present study was aimed to compare airway responses in patients  with rhinitis symptoms alone following exercise challenge, and to  determine relationship of two different respiratory function tests.98 subjects with rhinitis were investigated by spirometry and impulse oscillometry before and after exercise challenge.No  significant difference was detected  between spirometry and  impulse oscillometry measurements  before  and  after  exercise challenge in  subjects  with  rhinitis  alone.  No correlation between spirometry and impulse oscillometry indices was found in pre and post- exercise stages.We therefore conclude that exercise challenge is not an appropriate test to determine airway hyperresponsive in subjects with rhinitis symptoms alone and findings of spirometry and impulse oscillometry are not interrelated.

  19. Objective assessments of allergic and nonallergic rhinitis in young children

    DEFF Research Database (Denmark)

    Chawes, B L K; Kreiner-Møller, E; Bisgaard, H

    2009-01-01

    of age from the Copenhagen Prospective Study on Asthma in Childhood birth cohort assessing rhinitis history, specific immunoglobulin E relevant to rhinitis symptoms, nasal eosinophilia and nasal airway patency by acoustic rhinometry before and after decongestion. Associations were studied...

  20. Modulation of immune tolerance with a Chinese traditional prescription inhibits allergic rhinitis in mice

    OpenAIRE

    Min-Qiang Xie; Jie Liu; Zhen Long; Dao-Fa Tian; Chang-Qing Zhao; Ping-Chang Yang

    2011-01-01

    Background : Allergic diseases substantially affect human health and social economy. The pathogenesis is to be further understood. The effect of current therapeutic remedies on allergic diseases is not satisfactory. Aims : This study aimed to inhibit allergic rhinitis in a mouse model with a Chinese traditional medical prescription, Bu-Zhong-Yi-Qi-Tang. Material and Methods : A mouse AR model was developed with ovalbumin (OVA) plus adjuvant alum. The AR clinical symptoms and immune pathology ...

  1. Effect of Retinoic Acid in a Mouse Model of Allergic Rhinitis

    OpenAIRE

    Son, Hye-Lim; Park, Hyang-Rim; Park, Yong-Jin; Kim, Soo-Whan

    2015-01-01

    Purpose All-trans retinoic acid (ATRA) modulates immune responses by affecting T cells. Several studies have revealed that allergic inflammation of the lower airways is negatively associated with the vitamin A concentration. However, the role of ATRA in allergic inflammation of the upper airways is unclear. We investigated the effects of ATRA in an allergic rhinitis mouse model. Methods BALB/c mice except control groups (CON group) were sensitized with and challenged intra-nasally with Dermat...

  2. Prevalence of asthma and allergic rhinitis among adults in Yaounde, Cameroon.

    Directory of Open Access Journals (Sweden)

    Eric Walter Pefura-Yone

    Full Text Available Population-based estimates of asthma and allergic rhinitis in sub-Saharan African adults are lacking. We assessed the prevalence and determinants of asthma and allergic rhinitis in urban adult Cameroonians.A community-based survey was conducted from December 2013 to April 2014 among adults aged 19 years and above (N = 2,304, 57.3% women, selected through multilevel stratified random sampling across all districts of Yaounde (Capital city. Internationally validated questionnaires were used to investigate the presence of allergic diseases. Logistic regressions were employed to investigate the determinants of allergic conditions.Prevalence rates were 2.7% (95% CI: 2.1-3.4 for asthma-ever, 6.9% (5.9-7.9 for lifetime wheezing, 2.9% (92.2-3.6 for current wheezing and 11.4% (10.1-12.7 for self-reported lifetime allergic rhinitis; while 240 (10.4% participants reported current symptoms of allergic rhinitis, and 125 (5.4% had allergic rhino-conjunctivitis. The prevalence of current asthma medication use and self-reported asthma attack was 0.8 (0.4-1.2 and 1 (0.6-1.4 respectively. Multivariable adjusted determinants of current wheezing were signs of atopic eczema [2.91 (1.09-7.74] and signs of allergic rhinitis [3.24 (1.83-5.71]. Age group 31-40 years [0.27(0.09-0.78, p = 0.016] was an independent protective factor for wheezing. Determinants of current rhinitis symptoms were active smoking [2.20 (1.37-3.54, p<0.001], signs of atopic eczema [2.84 (1.48-5.46] and current wheezing [3.02 (1.70-5.39].Prevalence rates for asthma and allergic rhinitis among adults in this population were at the lower tails of those reported in other regions of the world. Beside the classical interrelation between allergic diseases found in this study, active smoking was an independent determinant of allergic rhinitis symptoms. Nationwide surveys are needed to investigate regional variations.

  3. The research of intensity focused ultrasound on the treatment of allergic rhinitis%聚焦超声治疗变应性鼻炎研究进展

    Institute of Scientific and Technical Information of China (English)

    林欣然; 张龙城

    2012-01-01

    Allergic rhinitis is a common disease in otorhinolaryngology, there are lots of physiotherapies now, the overview of the research of intensily focused ultrasound on the treatment of allergic rhinitis was mainly reviewed.

  4. IQ Score of Children with Persistent or Perennial Allergic Rhinitis: A Comparison with Healthy Children

    Science.gov (United States)

    GHAFFARI, Javad; ABBASKHANIAN, Ali; JALILI, Masumeh; YAZDANI CHARATI, Jamshid

    2014-01-01

    Objective Prevalence of allergies is different around the world. Allergic rhinitis is a common chronic disease in children. Intelligence quotient (IQ) is an indicator of efficacy and many factors including chronic diseases may affect it. This study compares the IQs of children diagnosed with persistent or perennial allergic rhinitis with healthy children. Material & Methods This was a comparative study that was conducted from June 2011–May 2013 in an academic referral clinic. In this study, 90 patients aged 6- to 14-yearsold who were diagnosed with persistent or perennial allergic rhinitis and were compared to 90 age and gender match healthy patients from their respective families. The Wechsler Intelligence Scale for Children was used to divide and calculate overall IQ, verbal IQ, and practical IQ. The t-test and chi square were used to analyze quantitative variables and qualitative variables, respectively. Results In this study, out of total 180 children, 90 (50%) in the case group and 90 children (50%), the control group participated for IQ comparison. One hundred (57%) were male and 80 (43%) were female. The overall IQ for allergic rhinitis patients and healthy patients was 109.2 and 107.5, respectively. This difference was not considered significant. Furthermore, there was no significant difference between the IQ scores of males and females. Conclusion Although allergic rhinitis is a chronic disease and effects quality of life, there were no identifiable negative effects on IQ. PMID:25143773

  5. Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

    Directory of Open Access Journals (Sweden)

    Nilsson Daniel

    2012-08-01

    Full Text Available Abstract Background The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes. Methods A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls. Results The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding risk-associated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations. Conclusions Haplotypes in the TLR7-TLR8 gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.

  6. [T-cells regulate the immune-response in allergic rhinitis].

    Science.gov (United States)

    Klimek, L; Böttcher, I

    2008-10-01

    Allergic diseases show a broad variety of symptoms, depending on the type of allergen and the location where it interacts with the human body. Contact of allergens with the upper respiratory tract result in conjunctivitis or allergic rhinitis. Apart from antigenpresenting cells, T-cells do play an important role in this hypersensibility reaction. Due to the production and secretion of cytokines, T-lymphocytes induce and maintain the corresponding Th-immuneresponse. In addition to regulatory functions, T-cells have potential influence on the chronic progression of allergic inflammatory reactions of the nasal mucosa and are therefore interesting target cells for specific immunotherapy as well as corticosteroid treatment. This article shows the specific function of T-cells during allergic rhinitis and reveals the basics for understanding the mechanism of immunotherapy and chronification of inflammatory allergic diseases of the nasal mucosa. PMID:18839392

  7. The Impact of Allergic Rhinitis and Asthma on Human Nasal and Bronchial Epithelial Gene Expression

    OpenAIRE

    Ariane H. Wagener; Aeilko H Zwinderman; Luiten, Silvia; Fokkens, Wytske J; Bel, Elisabeth H; Sterk, Peter J.; van Drunen, Cornelis M

    2013-01-01

    Background The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. Objective Defining gene expression profiles of primary nasal and bronchial epithelial cells from the same individua...

  8. Evaluation of impermeable covers for bedding in patients with allergic rhinitis

    OpenAIRE

    Terreehorst, I.; Hak, Eelko; Oosting, A.J.; Tempels-Pavlica, Z.; de Monchy, J. G.; Bruijnzeel-Koomen, C.A.; Aalberse, Rob; Gerth Van Wijk, Roy

    2003-01-01

    textabstractBACKGROUND: Encasing bedding in impermeable covers reduces exposure to house-dust mites, but the clinical benefit of this intervention as part of mite-avoidance measures for patients with allergic rhinitis is not known. We performed a multicenter, randomized, placebo-controlled trial of one year of use of impermeable bedding covers in the bedrooms of patients with rhinitis who were sensitized to house-dust mites to determine the effects on the signs and symptoms of disease. METHOD...

  9. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population

    OpenAIRE

    Jin Lianhong; Lü Fuzhen; Sui Hong; Zhang Ximei; Su Dongju; Zhang Jing

    2008-01-01

    Abstract Background Rhinitis and asthma are very common diseases involving genetic and environmental factors. Most patients with asthma also have rhinitis, which suggests the concept of 'one airway, one disease.' A disintegrin and metalloproteinase 33 (ADAM33) is the first asthma-susceptible gene to be discovered by positional cloning. To evaluate the potential influence of ADAM33 gene polymorphisms on allergic rhinitis (AR) and allergic asthma (AS), a case-control study was conducted on the ...

  10. Association between allergic rhinitis and hospital resource use among asthmatic children in Norway

    DEFF Research Database (Denmark)

    Sazonov Kocevar, V; Thomas, J; Jonsson, L;

    2005-01-01

    of concomitant allergic rhinitis on asthma-related hospital resource utilization among children below 15 years of age with asthma in Norway. METHODS: A population-based retrospective cohort study of children (aged 0-14 years) with asthma was conducted using data from a patient-specific public national database......BACKGROUND: Preliminary evidence suggests that inadequately controlled allergic rhinitis in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. The objective of this study was therefore to assess the effect...... of hospital admissions during a 2-year period, 1998-1999. Multivariate linear regression, adjusting for risk factors including age, gender, year of admission, urban/rural residence and severity of asthma episode, estimated the association between allergic rhinitis and total hospital days. A multivariate Cox...

  11. Efficacy of ebastine in the treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    Mei Li

    2016-01-01

    Objective:To observe the clinical efficacy of ebastine in the treatment of allergic rhinitis (AR) and its safety.Methods: A total of 80 patients with AR who were admitted in our hospital from March, 2014 to January, 2015 were included in the study and divided into the study group and the control group with 40 cases in each group according to different treatment protocols. The patients in the two groups were given nasal spray of budesonide (Rhinocort). On this basis, the patients in the study group were orally given ebastine. The improvement of symptoms and the occurrence of adverse reactions before and after treatment in the two groups were compared. The double antibody sandwich ELISA was used to detect the levels of VCAM-1, IL-4, and IL-10.Results: The comparison of serum VCAM-1, IL-4, and IL-10 before treatment between the two groups was not statistically significant. After treatment, the levels of serum VCAM-1, IL-4, and IL-10 were significantly reduced when compared with before treatment. The levels of serum VCAM-1, IL-4, and IL-10 after treatment in the study group were significantly lower than those in the control group. The improvement of clinical symptoms after treatment in the study group was significantly superior to that in the control group. No obvious adverse reactions occurred during the treatment period in the two groups.Conclusions:Ebastine in the treatment of AR can significantly reduce the inflammatory reaction, and alleviate the clinical symptoms with no obvious adverse reactions and accurate efficacy.

  12. Masticatory Changes in Oral Breath Secondary to Allergic Rhinitis: Integrative Review

    Directory of Open Access Journals (Sweden)

    Bezerra, Luciana Ângelo

    2014-04-01

    Full Text Available Introduction The III Brazilian Consensus on Rhinitis (2012 defines allergic rhinitis as a nasal mucosa inflammation, mediated by immunoglobulin E, after exposure to allergens. The classic signs and symptoms of allergic rhinitis are nasal obstruction, watery rhinorrhea, sneezing, and nasal itching, often reversible either spontaneously or with treatment, and mouth breathing (breathing predominantly through the mouth, regardless of the cause, due to a nasal breathing impairment in some cases. Objective To evaluate the literature on masticatory changes in children with mouth breathing due to allergic rhinitis. Methods We conducted a search of the past 10 years, at Bireme and MEDLINE databases, for articles that covered masticatory changes in children with mouth breathing secondary to allergic rhinitis. Results We found 1,986 articles, including 15 repeated in databases, but only two articles met the inclusion criteria fully. Discussion We found few studies to answer the question raised in this review, and those studies have some methodological limitations. Most articles claimed no have statistically significant differences in masticatory changes in this population. Conclusion A better controlled study (isolating diseases, exposure time, with a larger sample (sample calculation appropriate, would be necessary to examine such changes.

  13. IQ Score of Children with Persistent or Perennial Allergic Rhinitis: A Comparison with Healthy Children

    OpenAIRE

    Ghaffari, Javad; Ali ABBASKHANIAN; Masumeh JALILI; Yazdani Charati, Jamshid

    2014-01-01

    How to Cite This Article: Ghaffari J, Abbaskhanian A, Jalili M, Yazdani Charati Y. IQ Score of Children With Persistent or Perennial Allergic Rhinitis: Comparison with Healthy Children. Iran J Child Neurol. 2014 Summer; 8(3): 44-48. AbstractObjectivePrevalence of allergies is different around the world. Allergic rhinitis is a common chronic disease in children.Intelligence quotient (IQ) is an indicator of efficacy and many factors including chronic diseases may affect it. This study compares ...

  14. Hormetic Effect of Chronic Hypergravity in a Mouse Model of Allergic Asthma and Rhinitis

    OpenAIRE

    Tae Young Jang; Ah-Yeoun Jung; Young Hyo Kim

    2016-01-01

    We aimed to evaluate the effect of chronic hypergravity in a mouse model of allergic asthma and rhinitis. Forty BALB/c mice were divided as: group A (n = 10, control) sensitized and challenged with saline, group B (n = 10, asthma) challenged by intraperitoneal and intranasal ovalbumin (OVA) to induce allergic asthma and rhinitis, and groups C (n = 10, asthma/rotatory control) and D (n = 10, asthma/hypergravity) exposed to 4 weeks of rotation with normogravity (1G) or hypergravity (5G) during ...

  15. Clinical Distinctness of Allergic Rhinitis in Patients with Allergy to Molds

    OpenAIRE

    Krzysztof Kołodziejczyk; Andrzej Bozek

    2016-01-01

    Introduction. Molds are a very diverse group of allergens. Exposure and sensitization to fungal allergens can promote the development and worsening of allergic rhinitis (AR). Objective. The natural course of allergic rhinitis was compared between a group of patients with allergy to molds and patients with AR to other allergens as the control groups. Material and Methods. The study group consisted of 229 patients, with a mean age of 27.4 ± 6.5 yrs. The study group was compared to groups of AR ...

  16. The Link between Allergic Rhinitis and Asthma: A Role for Antileukotrienes?

    Directory of Open Access Journals (Sweden)

    H Kim

    2008-01-01

    Full Text Available Allergic rhinitis and asthma are both chronic heterogeneous disorders, with an overlapping epidemiology of prevalence, health care costs and social costs in quality of life. Both are inflammatory disorders with a similar pathophysiology, and both share some treatment approaches. However, each disorder has an array of treatments used separately in controlling these atopic disorders, from inhaled corticosteroids, beta2-agonists and antihistamines to newer monoclonal antibody-based treatments. The present article reviews the shared components of allergic rhinitis and asthma, and examines recent evidence supporting antileukotrienes as effective agents in reducing the symptoms of both diseases.

  17. Acupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol

    Directory of Open Access Journals (Sweden)

    Kang Kyung-Won

    2009-07-01

    Full Text Available Abstract Background Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects of conventional medication. Acupuncture has been widely used to treat patients with allergic rhinitis, but the available evidence of its effectiveness is insufficient. Our objective is to evaluate the effectiveness of acupuncture in patients in Korea and China with persistent allergic rhinitis compared to sham acupuncture treatment or waitlist control. Methods This study consists of a multi-centre (two centres in Korea and two centres in China, randomised, controlled trial with three parallel arms (active acupuncture, sham acupuncture, and waitlist group. The active acupuncture and sham acupuncture groups will receive real or sham acupuncture treatment, respectively, three times per week for a total of 12 sessions over four weeks. Post-treatment follow-up will be performed a month later to complement these 12 acupuncture sessions. Participants in the waitlist group will not receive real or sham acupuncture treatments during this period but will only be required to keep recording their symptoms in a daily diary. After four weeks, the same treatment given to the active acupuncture group will be provided to the waitlist group. Discussion This trial will provide evidence for the effectiveness of acupuncture as a treatment for persistent allergic rhinitis. The primary outcome between groups is a change in the self-reported total nasal symptom score (i.e., nasal obstruction, rhinorrhea, sneezing, and itching from baseline at the fourth week. Secondary outcome measures include the Rhinitis Quality of Life Questionnaire score and total non-nasal symptom score (i.e., headache, itching, pain, eye-dropping. The quantity of conventional relief medication used during the follow-up period is another secondary outcome measure. Trial

  18. T cell transcriptional factors in allergic rhinitis and its association with clinical features

    OpenAIRE

    Mo, Ji-Hun; Chung, Young-Jun; Kim, Ji Hye

    2013-01-01

    Background Th2 cells are crucially important in allergic disease and the possible involvement of Treg and Th17 cells has not been clearly identified. Objective To identify the mRNA expression of T cell transcription factors in nasal mucosa in patients with allergic rhinitis (AR) and to reveal their correlations with clinical features. Methods Eighteen patients with AR and 12 controls with turbinate hypertrophy were included. mRNA expression of the following transcriptional factors in nasal mu...

  19. Antioxidant Status and Immune Activity of Glycyrrhizin in Allergic Rhinitis Mice

    OpenAIRE

    Wei-Jun Chen; Li Zhang; Ai-Guo Zhou; Xiao-Lan Li

    2011-01-01

    Oxidative stress is considered as a major risk factor that contributes to increased lipid peroxidation and declined antioxidants in some degenerative diseases. Glycyrrhizin is widely used to cure allergic diseases due to its medicinal properties. In the present study, we evaluated the role of glycyrrhizin on lipid peroxidation and antioxidant status in the blood and nasal mucosa of allergic rhinitis (AR) mice. Mice were divided into six groups: normal control mice, model control (MC) mice, th...

  20. Apakah terapi pengendalian plak dapat menurunkan keparahan rinitis alergika pada anak? (Does oral plaque control therapy reduce severity of allergic rhinitis in children?)

    OpenAIRE

    Haryono Utomo; Darmawan Setijanto

    2005-01-01

    Allergic rhinitis is one of the most common ailments in children. In clinical practice approximately 50% of patients with symptoms of rhinitis are diagnosed with non-allergic rhinitis. Positive skin prick test or specific IgE in vitro tests that are relevant to aeroallergens are conclusive diagnostic of allergic rhinitis. However, simple diagnostic method such as "sneezing sign" has already proved to be reliable. Hypersensitive children have humoral immune system (Th2) which release inflammat...

  1. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine.

    Science.gov (United States)

    Wang, Xue Yan; Lim-Jurado, Margaret; Prepageran, Narayanan; Tantilipikorn, Pongsakorn; Wang, De Yun

    2016-01-01

    Allergic rhinitis and urticaria are common allergic diseases that may have a major negative impact on patients' quality of life. Bilastine, a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. This agent does not interact with the cytochrome P450 system and does not undergo significant metabolism in humans, suggesting that it has very low potential for drug-drug interactions, and does not require dose adjustment in renal impairment. As bilastine is not metabolized and is excreted largely unchanged, hepatic impairment is not expected to increase systemic exposure above the drug's safety margin. Bilastine has demonstrated similar efficacy to cetirizine and desloratadine in patients with seasonal allergic rhinitis and, in a Vienna Chamber study, a potentially longer duration of action than fexofenadine in patients with asymptomatic seasonal allergic rhinitis. It has also shown significant efficacy (similar to that of cetirizine) and safety in the long-term treatment of perennial allergic rhinitis. Bilastine showed similar efficacy to levocetirizine in patients with chronic spontaneous urticaria and can be safely used at doses of up to fourfold higher than standard dosage (80 mg once daily). The fourfold higher than standard dose is specified as an acceptable second-line treatment option for urticaria in international guidelines. Bilastine is generally well tolerated, both at standard and at supratherapeutic doses, appears to have less sedative potential than other second-generation antihistamines, and has no cardiotoxicity. Based on its pharmacokinetic properties, efficacy, and tolerability profile, bilastine will be valuable in the management of allergic rhinitis and urticaria. PMID:27110120

  2. Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice

    Institute of Scientific and Technical Information of China (English)

    朱瑾; 吴军; 陈希炜; 易绍萱; 罗高兴; 贺伟峰

    2003-01-01

    Objective: To examine the role of recombinant adenovirus vector containing CTLA4Ig gene(Ad-CTLA4Ig) in the treatment of induced allergic rhinitis in mice.Methods: Allergic rhinitis was induced by sensitizing and challenging with ovalbumin(OVA).Ad-CTLA4Ig was intraperitoneally injected 30 min before OVA challenge.Adenovirus vector without inserted CTLA4Ig cDNA served as the control.The symptoms and morphological changes of nasal mucosa of each group were observed, and the serum levels of IgE against OVA were detected with ELISA.Results: There were no obvious symptoms and pathological changes in Ad-CTLA4Ig treated group, in which the serum OVA-specific IgE levels were significantly lower than that in control groups(P< 0.05).Conclusion: Ad-CTLA4Ig prevents and treats allergic rhinitis of mice,implying the possibility of the usage of Ad-CTLA4Ig against allergic rhinitis in clinic in future.

  3. Hormetic Effect of Chronic Hypergravity in a Mouse Model of Allergic Asthma and Rhinitis

    Science.gov (United States)

    Jang, Tae Young; Jung, Ah-Yeoun; Kim, Young Hyo

    2016-06-01

    We aimed to evaluate the effect of chronic hypergravity in a mouse model of allergic asthma and rhinitis. Forty BALB/c mice were divided as: group A (n = 10, control) sensitized and challenged with saline, group B (n = 10, asthma) challenged by intraperitoneal and intranasal ovalbumin (OVA) to induce allergic asthma and rhinitis, and groups C (n = 10, asthma/rotatory control) and D (n = 10, asthma/hypergravity) exposed to 4 weeks of rotation with normogravity (1G) or hypergravity (5G) during induction of asthma/rhinitis. Group D showed significantly decreased eosinophils, neutrophils, and lymphocytes in their BAL fluid compared with groups B and C (p polymerase chain reaction using lung homogenate, the expression of IL-1β was significantly upregulated (p < 0.001) and IL-4 and IL-10 significantly downregulated (p < 0.05) in group D. Infiltration of inflammatory cells into lung parenchyma and turbinate, and the thickness of respiratory epithelium was significantly reduced in group D (p < 0.05). The expression of Bcl-2 and heme oxygenase-1 were significantly downregulated, Bax and extracellular dismutase significantly upregulated in Group D. Therefore, chronic hypergravity could have a hormetic effect for allergic asthma and rhinitis via regulation of genes involved in antioxidative and proapoptotic pathways. It is possible that we could use hypergravity machinery for treating allergic respiratory disorders.

  4. Specific immunotherapy can greatly reduce the need for systemic steroids in allergic rhinitis

    DEFF Research Database (Denmark)

    Aasbjerg, Kristian; Torp-Pedersen, C; Backer, V

    2012-01-01

    Worldwide, more than 400 million individuals have allergic rhinitis, which has a significant impact on the individual's general health. Most patients self-medicate with over-the-counter drugs, but severe cases need treatment with topical corticosteroids and/or immunotherapy (SCIT). Although...

  5. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis

    DEFF Research Database (Denmark)

    Costa, D J; Marteau, P; Amouyal, M;

    2014-01-01

    BACKGROUND/OBJECTIVES: An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out in pat...

  6. THE MAIN CULPRIT IN ALLERGIC RHINITIS - HOUSE DUST OR HOUSE DUST MITE

    OpenAIRE

    Abhey

    2015-01-01

    Allergic rhinitis especially perennial type makes life miserable for the patient. House dust mite is one of the major players causing it. This study is to compare the allergen i n city of house dust mite versus house dust and evaluate any cross - allergenicity between them. STUDY DESIGN: Prospective study in a tertiary referral ...

  7. THE MAIN CULPRIT IN ALLERGIC RHINITIS - HOUSE DUST OR HOUSE DUST MITE

    Directory of Open Access Journals (Sweden)

    Abhey

    2015-10-01

    Full Text Available Allergic rhinitis especially perennial type makes life miserable for the patient. House dust mite is one of the major players causing it. This study is to compare the allergen i n city of house dust mite versus house dust and evaluate any cross - allergenicity between them. STUDY DESIGN: Prospective study in a tertiary referral hospital. MATERIALS & METHODS: Forty patients of allergic rhinitis and well matched controls were subjected to intradermal skin tests to house dust and house dust mite allergen. The skin tests were graded as per standard norms and the responses matched after correlating with different parameters. Statistical analysis was done and the results evaluated. RESULTS: House dust mite was the main allergen, as compared to house dust, responsible for causing allergic rhinitis. The allergen reactivity potential of house dust mite was significantly more as compared to house dust. And, as such there was no statistically significant cross - allergenicity between the two groups. CONCLUSION: House dust mite rather than house dust is the main culprit in causing allergic rhinitis. Hence, precautionary and preventive measures to control the exposure to house dust mite can be undertaken

  8. Allergic Rhinitis: Burden of Illness, Quality of Life, Comorbidities, and Control.

    Science.gov (United States)

    Meltzer, Eli O

    2016-05-01

    Allergic rhinitis is a highly prevalent and costly condition. The disease burden suffered by patients includes the morbidity of the nasal symptoms, the impairment of multiple domains of quality of life, and numerous comorbidities. The goal of therapy is long-term good control. PMID:27083099

  9. Evaluation of impermeable covers for bedding in patients with allergic rhinitis

    NARCIS (Netherlands)

    I. Terreehorst; E. Hak (Eelko); A.J. Oosting; Z. Tempels-Pavlica; J.G. de Monchy; C.A. Bruijnzeel-Koomen; R.C. Aalberse (Rob); R. Gerth van Wijk (Roy)

    2003-01-01

    textabstractBACKGROUND: Encasing bedding in impermeable covers reduces exposure to house-dust mites, but the clinical benefit of this intervention as part of mite-avoidance measures for patients with allergic rhinitis is not known. We performed a multicenter, randomized, placebo-co

  10. Allergic rhinitis is associated with otitis media with effusion

    DEFF Research Database (Denmark)

    Kreiner-Møller, E; Chawes, B L K; Thomasen, Per Caye;

    2012-01-01

    Childhood otitis media with effusion is a common disease and a link to allergic diseases has been suggested.......Childhood otitis media with effusion is a common disease and a link to allergic diseases has been suggested....

  11. ALLERGIC RHINITIS AND ADENOID HYPERTROPHY IN CHILDREN: IS ADENOIDECTOMY ALWAYS REALLY USEFUL?

    Science.gov (United States)

    Colavita, L; Miraglia Del Giudice, M; Stroscio, G; Visalli, C; Alterio, T; Pidone, C; Pizzino, M R; Arrigo, T; Chimenz, R; Salpietro, C; Cuppari, C

    2015-01-01

    Allergic rhinitis (AR) and adenoid hypertrophy (AH) are common in children and are often associated with each other. Recent studies have shown improvement of respiratory symptoms and reduction in the adenoid volume after anti-allergic medical therapy (intranasal corticosteroids, antihistamines). The aim of our retrospective study is to evaluate the effectiveness of adenoidectomy on respiratory symptoms in pediatric patients with AR. We recruited 404 pediatric patients with AR, and we divided them into 4 groups (1. intermittent-mild rhinitis; 2. intermittent-moderate/severe rhinitis; 3. persistent-mild rhinitis; 4. persistent-moderate/severe rhinitis), using ARIA classification. For each patient we evaluated: age at onset of AR; family history of allergy; the presence of other allergic diseases; serum total IgE values; skin prick test (SPT) results; presence of AH evaluated by rhino-laringeal fibroscopy; adenoidectomy and its efficacy on respiratory symptoms. Our data show an association between AR and AH: 90 of 404 (22%) children with AR had AH of a degree greater than 2nd. A significant percentage (80%) of children suffering from AR did not present satisfactory benefits from adenoidectomy. They reported persistence or recurrence of rhinitic symptoms after surgery or only partial benefits, especially of recurrent respiratory tract infections and nasal obstruction. The local allergic persistent inflammation on nasal mucosa and adenoid tissue is probably the cause of the unsatisfactory results of adenoidectomy, therefore surgery cannot be the first therapeutic step for these children. It is important to extinguish the local inflammation by medical anti-allergic therapy to obtain improvements of nasal symptoms and to prevent adenoid regrowth.

  12. Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach.

    Directory of Open Access Journals (Sweden)

    Giusy Daniela Albano

    Full Text Available Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss, nasal wash (NW and plasma (P from Healthy Controls (HC and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORγ(t and FOXP3 in peripheral blood T-lymphocytes from intermittent and mild-moderate asthma. The effect of Budesonide and Formoterol was tested "in vitro" on IL-17A, RORγ(t and FOXP3 expression in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis patients, and on nasal and bronchial epithelial cells stimulated with NW and Ss from mild-moderate asthma/persistent rhinitis. Further, the effect of 12 weeks of treatment with Budesonide and Formoterol was tested "in vivo" in T-lymphocytes from mild-moderate asthma/persistent rhinitis patients. IL-17A was increased in Ss, NW and P from children with mild-moderate asthma compared with intermittent and HC. In cultured T-lymphocytes IL-17A and RORγ(t expression were higher in mild-moderate asthma/persistent rhinitis than in mild-moderate asthma/intermittent rhinitis, while FOXP3 was reduced. Budesonide with Formoterol reduced IL-17A and RORγ(t, while increased FOXP3 in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis, and reduced the IL-8 release mediated by IL-17A present in NW and Ss from mild-moderate asthma/persistent rhinitis in nasal and bronchial epithelial cells. Finally, Budesonide with Formoterol reduced IL-17A levels in P and Ss, CD4(+IL-17A(+T-cells, in naïve children with mild-moderate asthma/persistent rhinitis after 12 weeks of treatment. Th17 mediated immunity may be involved in the airway disease of children with allergic asthma and allergic rhinitis. Budesonide with Formoterol might be a useful tool for its therapeutic control.

  13. Aeroallergens, atopy and allergic rhinitis in the Middle East.

    Science.gov (United States)

    Goronfolah, L

    2016-01-01

    The literature on the nature and prevalence of indoor and/or outdoor aeroallergens, atopy and symptoms of rhinitis and asthma in the Middle East region (defined here as Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Palestine, Qatar, Kingdom of Saudi Arabia - KSA, Syria, United Arab Emirates and Yemen) was reviewed. Although documentation was poor in all countries other than Iran and the KSA, a wide range of "global" and "local" aeroallergens (grass, weed and tree pollens, fungal spores, insect allergens, dander, and house dust mites) has been observed across the region. The prevalence of current self-reported or parent-reported symptoms of rhinitis ranged from 9% to 38%. Researchers have suggested that the high atopy rates and self-reported rhinitis rates are associated with an on-going shift towards a "western" lifestyle.

  14. Specific immunotherapy (SIT in the treatment of allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Gorenoi, Vitali

    2010-03-01

    Full Text Available Scientific background: Allergic rhinitis (AR exhibits a prevalence of approx. 20% in Germany and causes enormous costs in the health care system. Specific immunotherapy (SIT is considered to be the only potentially causal therapy for AR and mainly administered by two routes, subcutaneous (SCIT and sublinguale (SLIT. SIT promises a reduction of symptoms and the need for medication in patients with AR. Research questions: The question arises, to what extent is SIT effective and cost effective in the treatment of AR and which ethical-social and legal aspects have to be considered regarding its application. Methods: The literature search was accomplished in the electronic data bases MEDLINE, EMBASE etc. in February 2008. The medical evaluation was based on systematic reviews of blinded, randomised controlled studies (RCT. The economic evaluation included health-economic studies on the basis of RCT. Additionally, it was also searched for publications explicitly addressing ethical-social and legal aspects of the use of SIT. Results: Medical evaluationTwo reviews on SCIT and three on SLIT were included in the medical evaluation. For the evaluation of SIT with grass pollen results for short and medium-term effects are considered from several studies, for SIT with other seasonal allergens (e. g. tree pollen and with house dust mite allergens from clearly fewer studies and for SIT with other perennial allergens only from a few. The reviews report a significant reduction of the symptom and medication score in favour of SCIT with seasonal allergens and recognise the effectiveness at least for grass pollen allergens. Also for other seasonal allergens SCIT is appraised as effective. The reviews about SLIT determine a significant reduction of the symptom and the medication score in favour of SLIT vs. placebo in short and medium term follow-up in evaluations across all allergens. The subgroup analyses show a significant reduction of the symptom and medication

  15. Cytotoxic T lymphocytes mediate chronic inflammation of the nasal mucosa of patients with atypical allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Shuqi Qiu

    2011-01-01

    Full Text Available Background : The prevalence of chronic rhinitis is increasing rapidly; its pathogenesis is to be further understood; immune inflammation is one of the possible causative factors. Antigen specific CD8+ T cells play a critical role in the induction of chronic inflammation. Aims : This study aimed to investigate the role of antigen specific CD8+ T cells in the pathogenesis of chronic atypical allergic rhinitis. Material and Methods : Nasal mucosal epithelial surface scratching samples were obtained from patients with chronic obstruction atypical allergic rhinitis. Exosomes were purified from the scratching samples and examined by immune gold electron microscopy. The effect of exosomes on modulating dendritic cell′s properties, the effect of exosome-pulsed dendritic cells on naïve T cell differentiation and the antigen specific CD8+ T cell activation were observed by cell culture models. Results : Exosomes purified from patients with chronic atypical allergic rhinitis carried microbial products, Staphylococcal enterotoxin B (SEB, and airborne antigen, Derp1. Dendritic cells pulsed by SEB/Derp1-carrying exosomes showed high levels of CD80, CD86 and the major histocompatibility class I (MHCI. Exosome-pulsed dendritic cells could induce the naïve CD3+ T cells to differentiate into CD8+ T cells. Upon the exposure to a specific antigen, the CD8+ T cells released granzyme B and perforin; more than 30% antigen specific CD8+ T cells proliferated. Conclusions : Antigen specific CD8+ T cells play an important role in the pathogenesis of chronic obstruction atypical allergic rhinitis.

  16. Mouse Model of Cat Allergic Rhinitis and Intranasal Liposome-Adjuvanted Refined Fel d 1 Vaccine

    Science.gov (United States)

    Tasaniyananda, Natt; Chaisri, Urai; Tungtrongchitr, Anchalee; Chaicumpa, Wanpen; Sookrung, Nitat

    2016-01-01

    Cats (Felis domesticus) are rich source of airborne allergens that prevailed in the environment and sensitized a number of people to allergy. In this study, a mouse model of allergic rhinitis caused by the cat allergens was developed for the first time and the model was used for testing therapeutic efficacy of a novel intranasal liposome-entrapped vaccines made of native Fel d 1 (major cat allergen) in comparison with the vaccine made of crude cat hair extract (cCE). BALB/c mice were sensitized with cCE mixed with alum intraperitoneally and intranasally. The allergic mice were treated with eight doses of either liposome (L)-entrapped native Fel d 1 (L-nFD1), L-cCE), or placebo on every alternate day. Vaccine efficacy evaluation was performed one day after provoking the treated mice with aerosolic cCE. All allergenized mice developed histological features of allergic rhinitis with rises of serum specific-IgE and Th2 cytokine gene expression. Serum IgE and intranasal mucus production of allergic mice reduced significantly after vaccination in comparison with the placebo mice. The vaccines also caused a shift of the Th2 response (reduction of Th2 cytokine expressions) towards the non-pathogenic responses: Th1 (down-regulation of the Th1 suppressive cytokine gene, IL-35) and Treg (up-regulation of IL-10 and TGF-β). In conclusions, a mouse model of allergic rhinitis to cat allergens was successfully developed. The intranasal, liposome-adjuvanted vaccines, especially the refined single allergen formulation, assuaged the allergic manifestations in the modeled mice. The prototype vaccine is worthwhile testing further for clinical use in the pet allergic patients. PMID:26954254

  17. Mouse Model of Cat Allergic Rhinitis and Intranasal Liposome-Adjuvanted Refined Fel d 1 Vaccine.

    Directory of Open Access Journals (Sweden)

    Natt Tasaniyananda

    Full Text Available Cats (Felis domesticus are rich source of airborne allergens that prevailed in the environment and sensitized a number of people to allergy. In this study, a mouse model of allergic rhinitis caused by the cat allergens was developed for the first time and the model was used for testing therapeutic efficacy of a novel intranasal liposome-entrapped vaccines made of native Fel d 1 (major cat allergen in comparison with the vaccine made of crude cat hair extract (cCE. BALB/c mice were sensitized with cCE mixed with alum intraperitoneally and intranasally. The allergic mice were treated with eight doses of either liposome (L-entrapped native Fel d 1 (L-nFD1, L-cCE, or placebo on every alternate day. Vaccine efficacy evaluation was performed one day after provoking the treated mice with aerosolic cCE. All allergenized mice developed histological features of allergic rhinitis with rises of serum specific-IgE and Th2 cytokine gene expression. Serum IgE and intranasal mucus production of allergic mice reduced significantly after vaccination in comparison with the placebo mice. The vaccines also caused a shift of the Th2 response (reduction of Th2 cytokine expressions towards the non-pathogenic responses: Th1 (down-regulation of the Th1 suppressive cytokine gene, IL-35 and Treg (up-regulation of IL-10 and TGF-β. In conclusions, a mouse model of allergic rhinitis to cat allergens was successfully developed. The intranasal, liposome-adjuvanted vaccines, especially the refined single allergen formulation, assuaged the allergic manifestations in the modeled mice. The prototype vaccine is worthwhile testing further for clinical use in the pet allergic patients.

  18. Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series

    OpenAIRE

    Taylor, M. A.; Reilly, D.; Llewellyn-Jones, R.H.; McSharry, C; Aitchison, T

    2000-01-01

    OBJECTIVE: To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series. Design: Randomised, double blind, placebo controlled, parallel group, multicentre study. SETTING: Four general practices and a hospital ear, nose, and throat outpatient department. PARTICIPANTS: 51 patients with perennial allergic rhinitis. Intervention: Random assignment to an oral 30c h...

  19. Assessment of asthma control using CARAT in patients with and without Allergic Rhinitis: A pilot study in primary care.

    OpenAIRE

    Domingos, M; R. Amaral; fonseca, ja; Azevedo, P.; Correia-de-Sousa, J

    2016-01-01

    BACKGROUND: Asthma and Allergic Rhinitis (AR) are two chronic inflammatory diseases that are often concomitant. The Control of Allergic Rhinitis and Asthma Test (CARAT) was developed to evaluate the control of these diseases from the patients' perspective. Its performance in asthma patients without AR has not been previously studied. AIM: To test the hypothesis that CARAT can be used to assess asthma control in patients with asthma and without AR. METHODS: A cross-sectional stu...

  20. Validation of control of allergic rhinitis and asthma test for children (CARATKids)--a prospective multicenter study

    OpenAIRE

    Linhares, DV; fonseca, ja; Borrego, LM; Matos, A; Pereira, AM; Sá-Sousa, A; Gaspar, A.; Mendes, C; Moreira, C.; Gomes, E; Rebelo, FF; Cidrais-Rodrigues, JC; Onofre, JM; Azevedo, LF; Alfaro, M

    2014-01-01

    BACKGROUND: Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) is the first questionnaire that assesses simultaneously allergic rhinitis and asthma control in children. It was recently developed, but redundancy of questions and its psychometric properties were not assessed. This study aimed to (i) establish the final version of the CARATKids questionnaire and (ii) evaluate its reliability, responsiveness, cross-sectional validity, and longitudinal validity. METHODS: ...

  1. Control of allergic rhinitis and asthma test – a formal approach to the development of a measuring tool

    OpenAIRE

    Fonseca Joao A; Vaz Marianela; Costa-Pereira Altamiro; Bugalho-Almeida António; Morais-Almeida Mario; Azevedo Luis F; Cruz-Correia Ricardo; Martins Sonia V; Nogueira-Silva Luis

    2009-01-01

    Abstract Background The concurrent management of allergic rhinitis and asthma (ARA) has been recommended by Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. However, a tool capable of assessing simultaneously the control of upper and lower airways diseases is lacking. Aim To describe the studies conducted to design the control of ARA test (CARAT) questionnaire. Methods We performed a literature review to generate a list of potentially important items for the assessment of control...

  2. Evaluation of total IgE, CRP and blood count parameters in children with asthma and allergic rhinitis

    OpenAIRE

    Feti Tülübaş; Ahmet Gürel; Mustafa Metin Donma; Burçin Nalbantoğlu; Birol Topçu; Zeynep Deniz Mut

    2013-01-01

    Objective: This study aimed to research retrospectivelywhether asthma and allergic rhinitis are related to totalIgE, C-reactive protein (CRP) and complete blood countparameters.Materials and methods: Files of 443 children who appliedto pediatric outpatient clinics of our hospital,aged2-18 were retrospectively investigated. Patients weregrouped into three as asthma (n=179), allergic rhinitis (n=171) and control group (n= 93). Patients’ ages, genders,total IgE, CRP and hemogram values were reco...

  3. Evaluation of total IgE, CRP and blood count parameters in children with asthma and allergic rhinitis

    OpenAIRE

    Tülübaş, Feti; Gürel, Ahmet; Donma, Mustafa Metin; NALBANTOĞLU, Burçin; TOPÇU, Birol; Mut, Zeynep Deniz

    2013-01-01

    Objective: This study aimed to research retrospectively whether asthma and allergic rhinitis are related to total IgE, C-reactive protein (CRP) and complete blood count parameters. Materials and methods: Files of 443 children who applied to pediatric outpatient clinics of our hospital,aged 2-18 were retrospectively investigated. Patients were grouped into three as asthma (n=179), allergic rhinitis (n= 171) and control group (n= 93). Patients\\' ages, genders, total IgE, CRP and hemogram va...

  4. Therapeutic Effects of Fermented Red Ginseng in Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study

    OpenAIRE

    Jung, Jae-Woo; Kang, Hye-Ryun; Ji, Geun-Eog; Park, Myeong-Soo; Song, Woo-Jung; Kim, Min-Hye; Kwon, Jae-Woo; Kim, Tae-Whan; Park, Heung-Woo; Cho, Sang-Heon; Min, Kyung-Up

    2011-01-01

    Purpose Allergic rhinitis is clinically defined as a disorder of the nose induced by IgE mediated inflammation after allergen exposure of the nasal mucosa. Many reports have stated that Panax ginseng and fermented red ginseng have anti-inflammatory effects, especially against Th2-type inflammation. This study was conducted to evaluate the therapeutic effects of fermented red ginseng in allergic rhinitis. Methods In this 4-week, double-blind, placebo-controlled study, 59 patients with persiste...

  5. The incidence of Common Allergens in Patients with Allergic Rhinitis Referred to Shahid Mofatteh Clinic, Yasuj, Iran

    OpenAIRE

    SH Nabavizadeh; SH Yazdanpanah; Abidi, H; M Zoladl

    2013-01-01

    Abstract Background & Aim: Allergic diseases are one of the most common diseases which are more prevalent in certain seasons. The aim of this study was to determine the prevalence of respiratory and food allergies to common allergens in patients with allergic rhinitis. Methods: This cross-sectional study was performed on 184 patients including 120 males and 64 females referred to the Shahid Mofatteh Clinic with the respiratory allergy symptoms including rhinitis, sneezing and coughing ...

  6. Effects of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis.

    Directory of Open Access Journals (Sweden)

    Yavuz Selim Yıldırım

    2013-09-01

    Full Text Available The objective of this study was to investigate the effect of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis.This prospective, self-comparised, single blind study was performed on patients with a history of at least two years of moderate-to-severe perennial allergic rhinitis that was not controlled  by  anti-allergic drugs.  Thirty-one  perennial  allergic rhinitis  patients  were enrolled in this study. Before starting the test population on their intranasal phototherapy, the same trained person took a nasal culture from each subject by applying a sterile cotton swab  along  each  side  of  the  nostril  and  middle  meatus.  Each  intranasal  cavity was irradiated three times a week for two weeks with increasing doses of irradiated. At the end  of  the  intranasal phototherapy,  nasal cultures were again obtained  from  the  each nostril The study found that after intranasal phototherapy, the scores for total nasal symptoms decreased significantly but bacterial proliferation was not significantly different before and after phototherapy.We  have  shown  that  intranasal  phototherapy  does  not  change  the  aerobic  nasal microbial flora in patients with perennial allergic rhinitis.

  7. Immunological role of nasal staphylococcus aureus carriage in patients with persistent allergic rhinitis

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    Mohamed Yousif Atia

    2008-10-01

    Full Text Available Nasal carriage of staphylococcus aureus (S.aureus exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done, skin prick test, nasal culture for S.aureus, nasal interleukin 4,nasal total IgE, serum total IgE and serum specific IgE(SSIgE for HDM. Nasal S.aureus was detected in 16/20 patients (80% and 5/20 (25% in healthy subjects with highly significant statistical difference plt0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r = 0.78, plt0.01 and significant positive correlation with SSIgE (HDM (r = 0.53, plt0.05, nasal total IgE (r = 0.39, plt0.05 and nasal IL-4 (r = 0.55, plt0.05. Nasal staph.aureus actively modulated the immune reaction in persistent allergic rhinitis patients by promoting local IgE production, so we recommend early detection and treatment of S.aureus carriage in patients

  8. Association of Allergic Rhinitis in Female University Students with Socio-economic Factors and Markers of Estrogens Levels.

    Science.gov (United States)

    Wronka, I; Kliś, K; Jarzebak, K

    2016-01-01

    The aim of this study is to investigate the association of allergic rhinitis in female university students with socio-economic factors and sex-hormone markers, including age at menarche, menstrual disorders, and selected anthropometrics indexes. The research was conducted among 640 female university students, aged 19-25 years. The measurements of body height, body mass, waist and hip circumference were taken. Each person completed a questionnaire. The occurrence of allergy was determined on the basis of answers to the questions whether the allergy and its allergens were defined on the basis of medical workup. We found that a significantly larger number of cases of allergic rhinitis were recorded in the university students coming from families of high socio-economic level than those from lower level. Allergic rhinitis also was more frequent in the students who spent their childhood in cities than in those who lived in the countryside. The prevalence of allergic rhinitis was inversely correlated to the number of siblings. There were no differences in the prevalence of allergic rhinitis in relation to the birth order. The estrogen level seemed unassociated with rhinitis. However, there were slightly more allergic among females with an earlier age of menarche. PMID:26453067

  9. Critical appraisal of Timothy grass pollen extract GRAZAX in the management of allergic rhinitis.

    Science.gov (United States)

    Scaparrotta, Alessandra; Attanasi, Marina; Petrosino, Marianna I; Di Filippo, Paola; Di Pillo, Sabrina; Chiarelli, Francesco

    2015-01-01

    Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP) allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense) pollen and ~15 μg major allergen P. pratense (rPhl p 5), may be the future of allergen-specific immunotherapy (IT) for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT.

  10. Grass pollen sublingual immunotherapy and paediatric allergic rhinitis: A patient-oriented decision.

    Science.gov (United States)

    Miceli Sopo, Stefano; Battista, Andrea; Greco, Monica; Monaco, Serena

    2016-01-01

    Guidelines and systematic review report that allergen immunotherapy (AIT) is, in general, effective in the treatment of allergic rhinitis. However, experts suggest not generalising the results of different clinical studies: for example, it would not be advisable to translate the results found in an adult population to a paediatric population or the results on the efficacy of AIT against a specific allergen to the AIT against a different allergen. Moreover, according to Evidence Based Medicine (EBM), clinical decisions are individualised and should derive from the "integration of best research evidence with clinical expertise and patient values". Taking into account the high specificity of the AIT and EBM principles, we tried to answer the question on how advisable it is to prescribe the AIT for the management of grass allergic rhinitis in children. To do this, we revised the scientific literature in order to solve a specific case scenario. PMID:26321601

  11. Ancillary therapy of intranasal T-LysYal® for patients with allergic, non-allergic, and mixed rhinitis.

    Science.gov (United States)

    Gelardi, M; Taliente, S; Fiorella, M L; Quaranta, N; Ciancio, G; Russo, C; Mola, P; Ciofalo, A; Zambetti, G; Caruso Armone, A; Cantone, E; Ciprandi, G

    2016-01-01

    Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction. Non-allergic rhinitis (NAR) is characterized by a non-IgE-mediated pathogenesis. Frequently, patients have the two disorders associated: such as mixed rhinitis (MR). Hyaluronic acid (HA) is a fundamental component of the human connective tissue. HA may exert anti-inflammatory and immune-modulating activities. Recently, an intranasal HA formulation was proposed: a supramolecular system containing lysine hyaluronate, thymine and sodium chloride (T-LysYal®). This randomized study investigated whether intranasal T-LysYal® (rinoLysYal®, Farmigea, Italy) was able to reduce symptom severity, endoscopic features, and nasal cytology in 89 patients (48 males and 41 females, mean age 36.3±7.1 years) with AR, NAR, and MR. Patients were treated with intranasal T-LysYal® or isotonic saline solution as adjunctive therapy to nasal corticosteroid and oral antihistamine for 4 weeks. Patients were visited at baseline, after treatment and after 4-week follow-up. Intranasal T-LysYal® treatment significantly reduced the quote of patients with symptoms, endoscopic features, and inflammatory cells. In conclusion, the present study demonstrates that intranasal T-LysYal® is able, as ancillary therapy, to significantly improve patients with AR, NAR, and MR, and its effect is long lasting. PMID:27049100

  12. The impact of co-existing seasonal allergic rhinitis caused by Japanese Cedar Pollinosis (SAR-JCP) upon asthma control status

    OpenAIRE

    Masayuki Hojo; Ken Ohta; Motoyasu Iikura; Junko Hirashima; Haruhito Sugiyama; Kazuhisa Takahashi

    2015-01-01

    Background: Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollinosis (SAR-JCP) is a most common allergic rhinitis, affecting about 40% in Japan, but the influence from SAR-JCP upon asthma is controversial. The purpose of this study is to investigate the effect of coexistence of SAR-JCP upon control status of asthma using SACRA (Self-Assessment of Allergic Rhinitis and Asthma Questionnaire). Methods: The design was prospective, single-center, observational study. Asthmatic patients we...

  13. Correlation between Serum Osteopontin and miR-181a Levels in Allergic Rhinitis Children

    OpenAIRE

    Wenlong Liu; Qingxiang Zeng; Renzhong Luo

    2016-01-01

    Background. Osteopontin (OPN) has been proved to be associated with allergic airway inflammation. However, the roles of OPN and its regulation in childhood allergic rhinitis (AR) are poorly understood. Objective. This study aims to evaluate the expression of OPN and miR-181a in children with AR and their association with Th1/Th2 immune response. Methods. Children who suffered from AR were included along with control subjects. Serum was collected to examine the level of OPN and Th1/Th2 cytokin...

  14. Airway function indicators and blood indicators in children with dust mite allergic rhinitis after sublingual immunotherapy

    Institute of Scientific and Technical Information of China (English)

    Hua Xiang

    2016-01-01

    Objective:To evaluate the airway function indicators and blood indicators in children with dust mite allergic rhinitis after sublingual immunotherapy.Methods:A total of 68 children with dust mite allergic rhinitis treated in our hospital from November, 2012 to October, 2015 were selected as the research subjects and randomly divided into observation group 34 cases and control group 34 cases. The control group received clinical routine therapy for allergic rhinitis, the observation group received sublingual immunotherapy, and then differences in basic lung function indicator values, small airway function indicator values and levels of serum inflammatory factors as well as serum ECP, TARC, Eotaxin-2 and VCAM were compared between two groups after treatment.Results:The FVC, FEV1, PEF and FEV1/FVC values of the observation group after treatment were higher than those of the control group (P<0.05); the MMEF, MEF50% and MEF25% values of the observation group were higher than those of the control group, and the proportion of AHR was lower than that of the control group (P<0.05); the serum IL-4, IL-9, IL-12, IL-13 and IL-16 levels of the observation group after treatment were lower than those of the control group, and the IL-10 and IL-12 levels are higher than those of the control group (P<0.05); the serum ECP, TARC, Eotaxin-2 and VCAM levels of the observation group children after treatment were lower than those of the control group (P<0.05). Conclusions:Sublingual immunotherapy for children with dust mite allergic rhinitis can optimize the airway function, reduce the systemic inflammatory response and eventually improve the children’s overall state, and it’s has positive clinical significance.

  15. Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial

    OpenAIRE

    Seo Yeon Choi; Kyungsook Park

    2016-01-01

    This study aimed to investigate the effects of aromatherapy oil inhalation on symptoms, quality of life, sleep quality, and fatigue level among adults with perennial allergic rhinitis (PAR). Fifty-four men and women aged between 20 and 60 were randomized to inhale aromatherapy oil containing essential oil from sandalwood, geranium, and Ravensara or almond oil (the placebo) for 5 minutes twice daily for 7 days. PAR symptoms determined by Total Nasal Symptom Score (TNSS), the Rhinoconjunctiviti...

  16. Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model

    OpenAIRE

    Avincsal, Mehmet Ozgür; Ozbal, Seda; Ikiz, Ahmet Omer; Pekcetin, Cetin; Güneri, Enis Alpin

    2014-01-01

    Objectives Allergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation area by passing through the interstitium and capillary walls. To pass through these barriers, the inflammatory cells degrade extracellular matrix proteins. Matrix metalloproteinases (MMPs) released by inflammatory cells mediate the degradatio...

  17. The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients

    OpenAIRE

    Keith Paul K; Desrosiers Martin; Laister Tina; Schellenberg R; Waserman Susan

    2012-01-01

    Abstract Background Allergic rhinitis (AR) is a common problem and we sought to examine the burden of disease and its management in Canada from the perspectives of patients and physicians. Methods Two parallel, Canadawide structured telephone interviews surveyed 1,001 AR patients and 160 physicians in July 2006. Results 44% of patients had experienced nasal symptoms unrelated to a cold and 20% had a physician diagnosis of AR. At screening 27% reported asthma, 15% chronic or recurrent sinusiti...

  18. Air pollution from livestock farms, and asthma, allergic rhinitis and COPD among neighbouring residents.

    OpenAIRE

    Smit, L A M; Hooiveld, M; Sman-de Beer, F. van der; Opstal-van Winden, A.W.J.; Beekhuizen, J.; Wouters, I.M.; Yzermans, J.; Heederik, D

    2014-01-01

    Objectives: There is an ongoing debate regarding environmental health risks of exposures to dust and microbial agents from livestock farming in the Netherlands. The aims of the study were (1) to investigate associations between indicators of air pollution from livestock farms and asthma, allergic rhinitis and chronic obstructive pulmonary disease (COPD) among neighbouring residents; and (2) to assess associations between farm exposures and endotoxin levels in participants' homes. Methods: Ele...

  19. Allergic rhinitis and asthma: inflammation in a one-airway condition

    OpenAIRE

    Haahtela Tari; Jeffery Peter K

    2006-01-01

    Abstract Background Allergic rhinitis and asthma are conditions of airway inflammation that often coexist. Discussion In susceptible individuals, exposure of the nose and lungs to allergen elicits early phase and late phase responses. Contact with antigen by mast cells results in their degranulation, the release of selected mediators, and the subsequent recruitment of other inflammatory cell phenotypes. Additional proinflammatory mediators are released, including histamine, prostaglandins, cy...

  20. Trends in Specific Immunotherapy for Allergic Rhinitis: A Survey of Chinese ENT Specialists

    OpenAIRE

    Zhou, Han; Tao, Qi-Lei; Wei, Jun-Min; Xu, Geng; Cheng, Lei

    2014-01-01

    Purpose Specific immunotherapy (SIT) is a suitable but uncommon treatment option for allergic rhinitis (AR) in China. The current understanding and attitude of Chinese ENT (ear, nose, and throat) specialists in regards to SIT is unclear. This study investigates current trends in the awareness and application status of SIT among Chinese ENT specialists. Methods We performed a nationwide, cross-sectional survey with a specially designed questionnaire given to 800 ENT specialists in China. A mem...

  1. Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis

    OpenAIRE

    Binhye Choi; Mun Seog Chang; Ha Young Kim; Jae-Woo Park; Bongha Ryu; Jinsung Kim

    2013-01-01

    Introduction. This study was designed to investigate the effects of low level laser therapy (LLLT) on experimental allergic rhinitis (AR) models induced by ovalbumin. Materials and Methods. AR was induced by 1% ovalbumin in mice. Twenty-four mice were divided into 4 groups: normal, control, low, and high dose irradiation. Low and high dose LLLT were irradiated once a day for 7 days. Total IgE, cytokines concentrations (IL-4 and IFN- γ ), and thymus and activation regulated chemokine (TARC) we...

  2. Prevalence of self-reported smoking experimentation in adolescents with asthma or allergic rhinitis

    OpenAIRE

    Silvia de Sousa Campos Fernandes; Cláudia Ribeiro de Andrade; Alessandra Pinheiro Caminhas; Paulo Augusto Moreira Camargos; Cássio da Cunha Ibiapina

    2016-01-01

    Objective: To determine the prevalence of smoking experimentation among adolescents with asthma or allergic rhinitis. Methods: This was a cross-sectional study involving adolescent students (13-14 years of age) in the city of Belo Horizonte, Brazil. The participants completed the Centers for Disease Control and Prevention and International Study of Asthma and Allergies in Childhood questionnaires, both of which have been validated for use in Brazil. We calculated the prevalence of smoking ...

  3. 167 Allergen Sensitization in Children with Allergic Rhinitis and Asthma in Guatemala

    OpenAIRE

    Rigalt, Ann Michelle; Maselli, Juan Pablo; Alvarado, Ninotchka; Carpio, Paola; Chur, Víctor; Mayén, Patricia; Morán, Edgar; Pinto, Mario; Rodríguez, Juan Manuel

    2012-01-01

    Background There are no previous studies published reporting allergen sensitizations in the population of most Central American countries, including Guatemala. There are many types of climates in different regions, with variable altitude, humidity, etc. The purpose of this study was to determine the most common allergen sensitizations in children with Allergic Rhinitis and Asthma in 4 different regions. Methods The study was performed on 461 children aged 5 to 15 years, from 4 different regio...

  4. Underdiagnosed and Undertreated Allergic Rhinitis in Urban School-Aged Children with Asthma

    OpenAIRE

    Esteban, Cynthia A.; Klein, Robert B.; Kopel, Sheryl J.; McQuaid, Elizabeth L.; Fritz, Gregory K.; Seifer, Ronald; York, Daniel; Golova, Natalie; Jandasek, Barbara; Koinis-Mitchell, Daphne

    2014-01-01

    Allergic rhinitis (AR) is a risk factor for the development of asthma, and if poorly controlled, it may exacerbate asthma. We sought to describe AR symptoms and treatment in a larger study about asthma, sleep, and school performance. We examined the proportion (1) who met criteria for AR in an urban sample of school children with persistent asthma symptoms, (2) whose caregivers stated that they were not told of their child's allergies, (3) who had AR but were not treated or were undertreated ...

  5. The impact of allergic rhinitis on the management of asthma in a working population

    OpenAIRE

    Provost, Dorothée; Iwatsubo, Yuriko; Riviere, Stéphanie; Mevel, Maëlaïg; Didier, Alain; Brochard, Patrick; Imbernon, Ellen; Raherison, Chantal

    2015-01-01

    Background Currently, little data is available about the management of asthma in the working population. The aim of this study was to describe asthma control and severity among workers according to current or previous allergic rhinitis comorbidity. Methods A network of occupational physicians participated in this pilot study on a voluntary basis. They included a random sample of salaried workers during their systematic occupational medical check-up. All subjects completed a self-administered ...

  6. Efficacy comparison of cetirizine and loratadine for allergic rhinitis in children

    Directory of Open Access Journals (Sweden)

    Juliana

    2012-03-01

    Full Text Available Background Allergic rhinitis represents a global health problem affecting 10% to more than 40% of the population worldwide. Several studies in recent years have described the efficacy of second-generation antihistamines in younger children. It is not well established whether cetirizine is more effective than loratadine in reducing symptoms of allergic rhinitis. Objective The objective of this study was to compare the efficacy of loratadine with cetirizine for treatment of allergic rhinitis. Methods We conducted a randomized, double-blind, controlled trial of 100 children, aged 13 to 16 years, from October to November 2009 at two junior high schools in Medan. Group I received 10 mg of cetirizine and group II received 10 mg of loratadine, each once daily in the morning for 14 days. Drug efficacy was assessed by changes from baseline symptom scores and evaluation of therapeutic responses after 3 days, 7 days and 14 days of treatment. Results The efficacy of cetirizine compared to that of loratadine was not statistically significant in diminishing nasal symptoms after 3 days, 7 days and 14 days of treatment (P=0.40, P=0.07, and P=0.057, respectively. Evaluation of side effects, however, revealed significantly fewer headaches in the cetirizine group after 3 days and 7 days of treatment (P=0.01 and P=0.03, respectively than in the loratidine group. In addition, the loratadine group had significantly more instances of palpitations after 7 days of treatment (P=0.04 compared to the cetirizine group. Conclusion There was no significant difference in cetirizine and loratadine treatment effectiveness on allergic rhinitis. However, loratadine was found to cause more headaches and palpitations than cetirizine. [Paediatr Indones. 2012;52:61-6].

  7. EFFECT OF SHADBINDU GHRITA NASYA AND HARIDRAKHANDA IN PRATISHYAYA: ALLERGIC RHINITIS

    OpenAIRE

    Sandhya Rani D; Seetha Devi P.; V. Shreeshananda Sharma

    2013-01-01

    Among Nasagath Rogas, most of the acharyas described pratishyaya with its complications which proves the seriousness of the disease. Acharya susrutha clearly mentioned in Uttar tantra that Pratishyaya is the disease condition in which Vata and Kapha dusti was observed. Allergic Rhinitis is a disease characterized by sudden and frequent attacks of sneezing, profuse watery nasal discharge associated with nasal obstruction which is intermittent, watering of the eyes, heaviness of head, respirato...

  8. Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Scaparrotta A

    2015-11-01

    Full Text Available Alessandra Scaparrotta, Marina Attanasi, Marianna I Petrosino, Paola Di Filippo, Sabrina Di Pillo, Francesco Chiarelli Department of Pediatrics, University of Chieti, Chieti, Italy Abstract: Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense pollen and ~15 µg major allergen P. pratense (rPhl p 5, may be the future of allergen-specific immunotherapy (IT for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT. Keywords: Timothy grass pollen extract, allergic rhinitis, Grazax, efficacy, safety, compliance

  9. EFFECT OF SHADBINDU GHRITA NASYA AND HARIDRAKHANDA IN PRATISHYAYA: ALLERGIC RHINITIS

    Directory of Open Access Journals (Sweden)

    Sandhya Rani. D

    2013-10-01

    Full Text Available Among Nasagath Rogas, most of the acharyas described pratishyaya with its complications which proves the seriousness of the disease. Acharya susrutha clearly mentioned in Uttar tantra that Pratishyaya is the disease condition in which Vata and Kapha dusti was observed. Allergic Rhinitis is a disease characterized by sudden and frequent attacks of sneezing, profuse watery nasal discharge associated with nasal obstruction which is intermittent, watering of the eyes, heaviness of head, respiratory distress and anosmia. The present study aims to comparatively evaluate the clinical efficacy of shadbindu gritha nasya with haridra khanda internally in pratishayaya. The principle objective of the study is to find a most effective, economical and simple treatment for pratishayaya. Here 45 patients of pratishyaya- Allergic Rhinitis were treated in 3 groups. 15 patient of group A treated with Shadbindu gritha Nasya. 15 patient of group B treated with Haridrakhanda orally. 15 patient of group C treated with both Shadbindu gritha nasya and haridrakhanda as a combined therapy. After the enrollment of the patients in the study, vital signs and symptoms of Pratishyaya-Allergic rhinitis such as Nasa srava, Khavatu, Nasa avarodha, gala talu shuskata, were studied before and after the treatment. The results of the study indicated that the group c bestowed with highly significant relief in almost all the signs and symptoms in comparison to group A and group B.

  10. Bronchial hyperreactivity and spirometric impairment in polysensitized patients with allergic rhinitis

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    Tosca Maria A

    2004-03-01

    Full Text Available Abstract Background We previously demonstrated in a group of patients with perennial allergic rhinitis alone impairment of spirometric parameters and high percentage of subjects with bronchial hyperreactivity (BHR. The present study aimed at evaluating a group of polysensitized subjects suffering from allergic rhinitis alone to investigate the presence of spirometric impairment and BHR during the pollen season. Methods One hundred rhinitics sensitized both to pollen and perennial allergens were evaluated during the pollen season. Spirometry and methacholine bronchial challenge were performed. Results Six rhinitics showed impaired values of FEV1 without referred symptoms of asthma. FEF 25–75 values were impaired in 28 rhinitics. Sixty-six patients showed positive methacholine bronchial challenge. FEF 25–75 values were impaired only in BHR positive patients (p Conclusions This study evidences that an impairment of spirometric parameters may be observed in polysensitized patients with allergic rhinitis alone during the pollen season. A high percentage of these patients had BHR. A close relationship between upper and lower airways is confirmed.

  11. Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis

    Science.gov (United States)

    Gupta, Manish; Chauhan, Komal

    2016-01-01

    Background: Antioxidants have a preventive or therapeutic role in oxygen free radical–mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis. Methods: Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks. Nasal and ocular symptoms were evaluated weekly by using a four-point categoric scale. The efficacy of the study drug was assessed based on the mean change from baseline of the total daytime nasal symptom scores, total nighttime nasal symptom scores, and the composite symptom scores. Results: The combined therapy (FF with antioxidants) resulted in marked improvements (p ≤ 0.05) in the mean total daytime nasal symptom scores, total nighttime nasal symptom scores, and composite symptom scores of subjects compared with ones treated with intranasal steroid (FF) alone, which highlighted the therapeutic effect of antioxidants in allergic rhinitis. Conclusion: Significant improvement in clinical outcome was observed in subjects who received antioxidants along with FF. However, because this was an open-label study, the results must be interpreted with caution, and further double-blind, placebo-controlled, dose-ranging trials supplemented with different antioxidants together with intranasal steroids are suggested.

  12. Allergic rhinitis and asthma: inflammation in a one-airway condition

    Directory of Open Access Journals (Sweden)

    Haahtela Tari

    2006-11-01

    Full Text Available Abstract Background Allergic rhinitis and asthma are conditions of airway inflammation that often coexist. Discussion In susceptible individuals, exposure of the nose and lungs to allergen elicits early phase and late phase responses. Contact with antigen by mast cells results in their degranulation, the release of selected mediators, and the subsequent recruitment of other inflammatory cell phenotypes. Additional proinflammatory mediators are released, including histamine, prostaglandins, cysteinyl leukotrienes, proteases, and a variety of cytokines, chemokines, and growth factors. Nasal biopsies in allergic rhinitis demonstrate accumulations of mast cells, eosinophils, and basophils in the epithelium and accumulations of eosinophils in the deeper subepithelium (that is, lamina propria. Examination of bronchial tissue, even in mild asthma, shows lymphocytic inflammation enriched by eosinophils. In severe asthma, the predominant pattern of inflammation changes, with increases in the numbers of neutrophils and, in many, an extension of the changes to involve smaller airways (that is, bronchioli. Structural alterations (that is, remodeling of bronchi in mild asthma include epithelial fragility and thickening of its reticular basement membrane. With increasing severity of asthma there may be increases in airway smooth muscle mass, vascularity, interstitial collagen, and mucus-secreting glands. Remodeling in the nose is less extensive than that of the lower airways, but the epithelial reticular basement membrane may be slightly but significantly thickened. Conclusion Inflammation is a key feature of both allergic rhinitis and asthma. There are therefore potential benefits for application of anti-inflammatory strategies that target both these anatomic sites.

  13. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

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    Greiff Lennart

    2012-06-01

    Full Text Available Abstract Background Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective To evaluate the efficacy and safety of intranasal AZD8848. Methods In a placebo-controlled single ascending dose study, AZD8848 (0.3-600 μg was given intranasally to 48 healthy subjects and 12 patients with allergic rhinitis (NCT00688779. In a placebo-controlled repeat challenge/treatment study, AZD8848 (30 and 60 μg was given once weekly for five weeks to 74 patients with allergic rhinitis out of season: starting 24 hours after the final dose, daily allergen challenges were given for seven days (NCT00770003. Safety, tolerability, pharmacokinetics, and biomarkers were monitored. During the allergen challenge series, nasal symptoms and lavage fluid levels of tryptase and α2-macroglobulin, reflecting mast cell activity and plasma exudation, were monitored. Results AZD8848 produced reversible blood lymphocyte reductions and dose-dependent flu-like symptoms: 30–100 μg produced consistent yet tolerable effects. Plasma interleukin-1 receptor antagonist was elevated after administration of AZD8848, reflecting interferon production secondary to TLR7 stimulation. At repeat challenge/treatment, AZD8848 reduced nasal symptoms recorded ten minutes after allergen challenge up to eight days after the final dose. Tryptase and α2-macroglobulin were also reduced by AZD8848. Conclusions Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis. Trial registration NCT00688779 and NCT00770003 as indicated above.

  14. Current issues on sublingual allergen-specific immunotherapy in children with asthma and allergic rhinitis

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    Živković Zorica

    2016-01-01

    Full Text Available In 1993 the European Academy of Allergy and Clinical Immunology was the first official organization to recognize that sublingual administration could be “promising route” for allergic desensitization. A few years later, the World Health Organization recommended this therapy as “a viable alternative to the injection route in adults.” The first meta-analysis showed sublingual allergen specific immunotherapy (SLIT effectiveness for allergic rhinitis and another study showed SLIT can actually help prevent the development of asthma both in adults and in children. The main goal of this review article is to present insight into the most up-to-date understanding of the clinical efficacy and safety of immunotherapy in the treatment of pediatric patients with allergic rhinitis and asthma. A literature review was performed on PubMed from 1990 to 2015 using the terms “asthma,” “allergic rhinitis,” “children,” “allergen specific immune therapy.” Evaluating data from double-blind placebo-controlled randomized clinical trials (DB-PC-RCTs, the clinical efficacy (assessed as the reduction of symptom score and the need of rescue medicament of SLIT for allergic rhinitis and allergic asthma, has been confirmed in various meta-analysis Outcomes such as rhinoconjunctivitis score and medication scores, combined scores, quality of life, days with severe symptoms, immunological endpoints, and safety parameters were all improved in the SLIT-tablet compared with placebo group. SLIT safety has been already proven in many DB-PC-RCTs and real-life settings. In accordance with all of the above mentioned, the goals for future trials and studies are the development of comprehensive guidelines for clinical practice on immunotherapy, embracing all the different potential participants. The importance of allergen immunotherapy is of special relevance in the pediatric age, when the plasticity and modulability of the immune system are maximal, and when

  15. Rhinitis Overview

    Science.gov (United States)

    ... Training Grants & Awards Program Directors Practice Resources ASTHMA IQ Consultation and Referral Guidelines Practice Financial Survey Practice ... with others. Join us on Facebook and Twitter . Test your knowledge about allergic rhinitis . » Rhinitis Symptoms & Diagnosis ...

  16. The incidence of Common Allergens in Patients with Allergic Rhinitis Referred to Shahid Mofatteh Clinic, Yasuj, Iran

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    SH Nabavizadeh

    2013-12-01

    Background & Aim: Allergic diseases are one of the most common diseases which are more prevalent in certain seasons. The aim of this study was to determine the prevalence of respiratory and food allergies to common allergens in patients with allergic rhinitis. Methods: This cross-sectional study was performed on 184 patients including 120 males and 64 females referred to the Shahid Mofatteh Clinic with the respiratory allergy symptoms including rhinitis, sneezing and coughing during 2012-2013. Data collection, checklist registered, including demographic information and data associated with sensitivity of skin prick test of 21 allergens were selected. Data were analyzed using descriptive and inferential statistical. Results: A number of 153 patients (83.2% were allergic to one or more of the 21 allergens tested, whereas 31 patients (16.8 of them showed no sensitivity. The most common allergic reactions to insect allergens were 73 cases (47.7%, grass and turf 58 cases (37.9% percent, Beetle 55 cases (35.9%, wheat flour, 51 (33.3% walnuts, 37 (24.4% and cat fur 36 (5/23.5% respectively.. Conclusion: Susceptibility to insects, beetles and grass had the highest prevalence in patients with allergic rhinitis referred to Super Specialized clinic in Yasuj. Because susceptibility to allergens depends on the environment, therefore, being aware of them can lead to avoidance and control allergic reactions. Key words: Allergic Disease, Skin Prick Test, Rhinitis

  17. Evaluation of Prevalence of Allergic Rhinitis Symptoms in Kurdistan, a Western Province in Iran

    Directory of Open Access Journals (Sweden)

    Rasoul Nasiri

    2015-11-01

    Full Text Available Introduction Allergic rhinitis, like other allergic diseases, is one of the most common disorders during childhood; this study was conducted to assess and compare the prevalence and severity of allergic rhinitis in children and adolescents living in Kurdistan province. The study was aimed to provide a ground for the identification of likely causes and risk factors of this disorder. Materials and Methods This study was a cross-sectional study. In order to collect data, 4,000 questionnaires were distributed to elementary schools and junior high schools and 3,890 questionnaires were completed; as a result, the survey response rate was 97%. The study was carried out based on International Study of Asthma and Allergies in Childhood (ISAAC: ISAAC questionnaire. After entering the data into SPSS version 13, they were analyzed using logistic regression and Chi- square test. Results Of a total 3,890 people, 29.7% of the subjects in this study reported a history of sneezing or runny nose in the past 12 months; it was reported more in boys in the age group 13-14 years and the difference between the sexes was significant [Odds ratio(OR=1.35, Confidence interval (CI]: 1.09-1.67, P < 0.01. Based on physician diagnosis, 9.37% of the subjects were overtaken by allergic rhinitis and it was more prevalent in boys at both educational levels and the difference was statistically significant in subjects aged 13-14 years old (OR=1.44 CI: 1.07-1.94, P

  18. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

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    Uddman Rolf

    2005-09-01

    Full Text Available Abstract Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been shown in several studies, but their possible function as mediators in allergy and asthma remains to be established. The present study was designed to examine the expression of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with intermittent allergic rhinitis, focusing on changes induced by exposure to pollen. Methods 27 healthy controls and 42 patients with seasonal allergic rhinitis volunteered for the study. Nasal biopsies were obtained before and during pollen season as well as before and after allergen challenge. The seasonal material was used for mRNA quantification of Toll-like receptors 2, 3 and 4 with real-time polymerase chain reaction, whereas specimens achieved in conjunction with allergen challenge were used for immunohistochemical localization and quantification of corresponding proteins. Results mRNA and protein representing Toll-like receptors 2, 3 and 4 could be demonstrated in all specimens. An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season. Conclusion The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation.

  19. Serum IL-10 Level in Allergic Rhinitis Patients and Its Effect on Serum Total IgE

    Institute of Scientific and Technical Information of China (English)

    LIU Guanghui; ZHU Rongfei

    2005-01-01

    To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE (TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed. In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34±2.48 pg/mL and 142. 6±28.2 KUA/L. In the normal control group, they were 12. 86±2.88 pg/mL and 47.2±12.2 KUA.There were significant differences between the two groups (P<0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r= -0.46, P=0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization of IgE. IL-10 plays an important role in the episode of allergic rhinitis.

  20. 5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: a real-life study

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    Pastorello EA

    2013-12-01

    Full Text Available Elide Anna Pastorello,1 Laura Losappio,1 Stefania Milani,2 Giuseppina Manzotti,3 Valentina Fanelli,4 Valerio Pravettoni,5 Fabio Agostinis,6 Alberto Flores D’Arcais,7 Ilaria Dell'Albani,8 Paola Puccinelli,9 Cristoforo Incorvaia,10 Franco Frati81Allergy and Immunology Department, Niguarda Hospital, Milan, 2Allergy Department, San Marco General Hospital, Bergamo, 3Allergy Department, Treviglio Hospital, Bergamo, 4Allergy Department, Italian Institute for Auxology, Milan, 5Clinical Allergy and Immunology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, 6Department of Pediatrics, Riuniti Hospital, Bergamo, 7Department of Pediatrics, Legnano Hospital, Milan, 8Medical and Scientific Department, Stallergenes Italy, Milan, 9Regulatory Department, Stallergenes Italy, Milan, 10Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyBackground: An important subpopulation in allergic rhinitis is represented by patients with severe form of disease that is not responsive to drug treatment. It has been reported that grass pollen subcutaneous immunotherapy is effective in drug-resistant patients. In a real-life study, we evaluated the efficacy of 5-grass pollen tablets in patients with grass pollen-induced allergic rhinitis not responsive to drug therapy.Methods: We carried out this multicenter observational study in adults and adolescents with grass-induced allergic rhinitis not responsive to drug therapy who were treated for a year with 5-grass pollen tablets. Clinical data collected before and after sublingual immunotherapy (SLIT included Allergic Rhinitis and its Impact on Asthma (ARIA classification of allergic rhinitis, response to therapy, and patient satisfaction.Results: Forty-seven patients entered the study. By ARIA classification, three patients had moderate to severe intermittent allergic rhinitis, ten had mild persistent allergic rhinitis, and 34 had moderate to severe persistent allergic rhinitis. There were no cases

  1. IQ Score of Children with Persistent or Perennial Allergic Rhinitis: A Comparison with Healthy Children

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    Javad GHAFFARI

    2014-07-01

    Full Text Available How to Cite This Article: Ghaffari J, Abbaskhanian A, Jalili M, Yazdani Charati Y. IQ Score of Children With Persistent or Perennial Allergic Rhinitis: Comparison with Healthy Children. Iran J Child Neurol. 2014 Summer; 8(3: 44-48. AbstractObjectivePrevalence of allergies is different around the world. Allergic rhinitis is a common chronic disease in children.Intelligence quotient (IQ is an indicator of efficacy and many factors including chronic diseases may affect it. This study compares the IQs of children diagnosed with persistent or perennial allergic rhinitis with healthy children.Material & MethodsThis was a comparative study that was conducted from June 2011–May 2013 in an academic referral clinic. In this study, 90 patients aged 6- to 14-yearsold who were diagnosed with persistent or perennial allergic rhinitis and were compared to 90 age and gender match healthy patients from their respective families. The Wechsler Intelligence Scale for hildren was used to divide and calculate overall IQ, verbal IQ, and practical IQ. The t-test and chi square were used to analyze quantitative variables and qualitative variables, respectively.Results In this study, out of total 180 children, 90 (50% in the case group and 90 children (50%, the control group participated for IQ comparison. One hundred (57% were male and 80 (43% were female. The overall IQ for allergic rhinitis patients and healthy patients was 109.2 and 107.5, respectively. This difference was not considered significant. Furthermore, there was no significant difference between the IQ scores of males and females.ConclusionAlthough allergic rhinitis is a chronic disease and effects quality of life, there were no identifiable negative effects on IQ.  ReferencesGhaffari J, Mohammadzadeh I, Khaliian A, Rafatpanah H, Mohammadjafari H, Davoudi A. Prevalence of asthma, allergic rhinitis and eczema in elementary schools in Sari(Iran. Caspian Journal of Internal Medicine

  2. Evaluation of total IgE, CRP and blood count parameters in children with asthma and allergic rhinitis

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    Feti Tülübaş

    2013-03-01

    Full Text Available Objective: This study aimed to research retrospectivelywhether asthma and allergic rhinitis are related to totalIgE, C-reactive protein (CRP and complete blood countparameters.Materials and methods: Files of 443 children who appliedto pediatric outpatient clinics of our hospital,aged2-18 were retrospectively investigated. Patients weregrouped into three as asthma (n=179, allergic rhinitis (n=171 and control group (n= 93. Patients’ ages, genders,total IgE, CRP and hemogram values were recorded.Results: While eosinophil count, MCHC and total IgElevels were significantly higher in asthma group, MCVlevels were significantly lower. Lymphocyte count, CRPand total IgE levels were significantly higher in allergicrhinitis group compared with control group whereas neutrophilcount were significantly lower and eosinophil countdid not change significantly. Total IgE levels were higherin asthma and allergic rhinitis compared with controls.However, CRP levels were higher only in allergic rhinitisgroup. MCV levels were significantly lower in asthmagroup compared with controls. MCHC levels were significantlyhigher in asthma group compared with allergicrhinitis and control groups. Neutrophil count decreasedwhile lymphocyte count increased significantly. Eosinophilcount significantly increased compared with controlgroup whereas a significant difference was not observedbetween allergic rhinitis and controls.Conclusions: Our findings suggest factors effective inasthma pathogenesis might be effective also in erythrocytemorphology. There are remarkable changes in bloodeosinophil levels in asthma and in neuthrophil and lymphocytelevels in allergic rhinitis. Serum total IgE level increasesin asthma group whereas it decreases in allergicrhinitis group.Key words: Asthma, allergic rhinitis, total IgE, CRP, MCV

  3. Management of allergic and non-allergic rhinitis: a primary care summary of the BSACI guideline.

    Science.gov (United States)

    Angier, Elizabeth; Willington, Jenny; Scadding, Glenis; Holmes, Steve; Walker, Samantha

    2010-09-01

    Rhinitis is a common problem in primary care which is often managed sub-optimally. It causes considerable morbidity and has been shown to have a detrimental impact on people's ability to concentrate at school and at work. Rhinitis and asthma often present together, and symptomatic rhinitis can be associated with poor asthma control and increased risk of exacerbations. There is therefore a clear need to recognise and treat rhinitis according to guideline recommendations. This article is a primary care summary of the British Society for Allergy & Clinical Immunology (BSACI) Standards of Care Committee guideline on the management of rhinitis, written by a multi-disciplinary group of clinicians. It takes into account the time restrictions on assessment and the tests and equipment available in primary care, as well as the need for practical, clear and intuitive strategies for investigation and management. It recommends a stepwise approach to treatment, and highlights the relevance of less frequently prescribed treatments, including nasal douching leukotriene receptor antagonists and anticholinergics. Red flag symptoms are identified, together with indicators for referral. As with many other long term conditions, good communication between primary and secondary care in terms of timely and appropriate referral is a key factor for success.

  4. Rhinitis

    DEFF Research Database (Denmark)

    Hansen, J W; Thomsen, S F; Nolte, H;

    2010-01-01

    BACKGROUND: Asthma and rhinitis often co-occur, and this potentially increases the disease severity and impacts negatively on the quality of life. We studied disease severity, airway responsiveness, atopy, quality of life and treatment in subjects with both asthma and rhinitis compared to patient...... both diseases were undertreated in 85% of the cases. CONCLUSION: We encourage that these observations be used in the evaluation and treatment of patients with asthma and rhinitis and that they contribute to the understanding of asthma and rhinitis as a uniform airways disease....

  5. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet

    DEFF Research Database (Denmark)

    Demoly, Pascal; Emminger, Waltraud; Rehm, Dorte;

    2016-01-01

    BACKGROUND: The SQ HDM SLIT-tablet (ALK) has been developed for treatment of house dust mite (HDM)-induced respiratory allergic disease. OBJECTIVE: This trial investigated the efficacy and safety of the SQ HDM SLIT-tablet in adults with moderate-to-severe HDM-induced allergic rhinitis (AR). METHODS......: The trial was a randomized, double-blind, placebo-controlled phase III trial conducted in 12 European countries including 992 adults with moderate-to-severe HDM-induced AR despite treatment with pharmacotherapy. Subjects were randomized 1:1:1 to 1 year of daily treatment with placebo, 6 SQ-HDM, or 12 SQ......-HDM. The primary end point was the total combined rhinitis score (ie, the sum of rhinitis symptom and medication scores) during the efficacy assessment period (approximately the last 8 weeks of the treatment period). Key secondary end points were rhinitis symptoms, medication scores, quality of life...

  6. Apakah terapi pengendalian plak dapat menurunkan keparahan rinitis alergika pada anak? (Does oral plaque control therapy reduce severity of allergic rhinitis in children?

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    Haryono Utomo

    2005-06-01

    Full Text Available Allergic rhinitis is one of the most common ailments in children. In clinical practice approximately 50% of patients with symptoms of rhinitis are diagnosed with non-allergic rhinitis. Positive skin prick test or specific IgE in vitro tests that are relevant to aeroallergens are conclusive diagnostic of allergic rhinitis. However, simple diagnostic method such as "sneezing sign" has already proved to be reliable. Hypersensitive children have humoral immune system (Th2 which release inflammatory factors in the presence of allergen or infection that contribute to allergic response. Immunological reactions occurred and antibodies concentration arise, especially specific IgE instead of IgG because of the isotype switching. A lot of procedures such as allergen avoidance, medication and immunotherapy were done in allergic rhinitis management. However, oral plaque controls were not the point of interest in this case. The aim of this study is to find out the effectiveness of oral plaque control in the reduction of severity of allergic rhinitis symptoms using symptom scores. Fifty children, male and female aged 8–14 years, subjective diagnosed as allergic rhinitis using "sneezing sign" were included in this study. Oral plaque control procedures were done by polishing and flossing followed by 4 days of gargling with 1% povidone iodine. Clinical result showed that after 3 days, oral plaque control 2.925 times more effective than control group. The conclusion was oral plaque control is effective reducing the severity of allergic rhinitis symptoms.

  7. The minimal clinically important difference of the control of allergic rhinitis and asthma test (CARAT) : cross-cultural validation and relation with pollen counts

    NARCIS (Netherlands)

    van der Leeuw, Sander; van der Molen, Thys; Dekhuijzen, P. N. Richard; Fonseca, Joao A.; van Gemert, Frederik A.; van Wijk, Roy Gerth; Kocks, Janwillem W. H.; Oosterom, Helma; Riemersma, Roland A.; Tsiligianni, Ioanna G.; de Weger, Letty A.; Oude Elberink, Joanne N. G.; Flokstra-de Blok, Bertine M. J.

    2015-01-01

    BACKGROUND: The Control of Allergic Rhinitis and Asthma Test (CARAT) monitors control of asthma and allergic rhinitis. AIMS: To determine the CARAT's minimal clinically important difference (MCID) and to evaluate the psychometric properties of the Dutch CARAT. METHODS: CARAT was applied in three mea

  8. The minimal clinically important difference of the control of allergic rhinitis and asthma test (CARAT): cross-cultural validation and relation with pollen counts

    NARCIS (Netherlands)

    Leeuw, S. van der; Molen, T. van der; Dekhuijzen, P.N.R.; Fonseca, J.A.; Gemert, F.A. van; Wijk, R. Gerth van; Kocks, J.W.; Oosterom, H.; Riemersma, R.A.; Tsiligianni, I.G.; Weger, L.A. de; Oude Elberink, J.N.; Flokstra-de Blok, B.M.

    2015-01-01

    BACKGROUND: The Control of Allergic Rhinitis and Asthma Test (CARAT) monitors control of asthma and allergic rhinitis. AIMS: To determine the CARAT's minimal clinically important difference (MCID) and to evaluate the psychometric properties of the Dutch CARAT. METHODS: CARAT was applied in three mea

  9. The frequency and importance of bronchial hyperreactivity in patients with allergic and non-allergic rhinitis.

    Science.gov (United States)

    Dziedziczko, A; Gniazdowski, R

    1977-01-01

    A trial was undertaken to evaluate the occurrence of bronchial hyperreactivity, typical of bronchial asthma, in 50 patients with hay fever (rhinitis allergica) and 45 patients with rhinitis vasomotorica nonallergica, as opposed to a group of healthy subjects and patients with bronchial asthma. All the patients were subjected to spirographic examinations at rest (VC, FEV1, ETT, SI), after exercise (PWC170), and after histamine inhalation. The authors believe that it is expedient to study bronchial hyperreactivity in patients with hay fever and rhinitis vasomotorica nonallergica in that it affords possibilities for the prevision of the conceivable unfavourable evolution of the disease towards the atopic or non-atopic bronchial asthma, as well as for the taking of adequate preventive and therapeutic measures. PMID:920144

  10. ASSOCIATION BETWEEN SMOKING AND ALLERGIC RHINITIS IN OTOLARYNGOLOGIC PATIENTS OF THE HOSPITAL UNIVERSITARIO DEL CARIBE. CARTAGENA. COLOMBIA. (IN SPANISH)

    OpenAIRE

    Morales-Valdés Lady Johana; Milanés-Pérez Rosa; Paternina-Caicedo Ángel José

    2014-01-01

    Introduction: the allergic rhinitis (AR) is a public health problem and the smoking continues having important prevalence in spite of numerous measures applied worldwide. Objective: to estimate the association between smoking and AR. Methods: analytic study, of cases and controls, in which the cases were patients with AR and the control ones, patients with other diseases of the high respiratory way non-related with the rhinitis. It was carried out in the Hospital Universitar...

  11. The minimal clinically important difference of the control of allergic rhinitis and asthma test (CARAT): cross-cultural validation and relation with pollen counts

    OpenAIRE

    De Leeuw, Sander; van der Molen, Thys; Dekhuijzen, P. N. Richard; Fonseca, Joao A; van Gemert, Frederik A.; Van Wijk, Roy Gerth; Kocks, Janwillem W H; Oosterom, Helma; Riemersma, Roland A; Tsiligianni, Ioanna G.; de Weger, Letty A.; Oude Elberink, Joanne N. G.; Flokstra-de Blok, Bertine M J

    2015-01-01

    BACKGROUND: The Control of Allergic Rhinitis and Asthma Test (CARAT) monitors control of asthma and allergic rhinitis. AIMS: To determine the CARAT's minimal clinically important difference (MCID) and to evaluate the psychometric properties of the Dutch CARAT. METHODS: CARAT was applied in three measurements at 1-month intervals. Patients diagnosed with asthma and/or rhinitis were approached. MCID was evaluated using Global Rating of Change (GRC) and standard error of measurement (s.e.m.). Cr...

  12. Understanding the role of the healthcare professional in patient self-management of allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Bonnie L Kuehl

    2015-08-01

    Full Text Available Objective: Allergic rhinitis is a common, usually long-standing, condition that may be self-diagnosed or have a formal diagnosis. Our aim was to identify how allergic rhinitis sufferers self-manage their condition. Methods: A sample of 276 self-identified adult allergy sufferers pooled from social media completed an online survey comprising 13 questions. The survey was fielded by a professional research organization (Lab42. The main outcome measures included the use of prescription and/or non-prescription allergy medication, and interactions with physician and/or pharmacist with respect to medication use. Results: Of the respondents, 53% (146/276 indicated that they used both prescription and over-the-counter medication to manage their allergy symptoms. Of those who used prescription medication, 53% reported that they discussed their prescription medication in great detail with their physician when it was prescribed, while 42% spoke about it briefly. Following the initial prescription, few discussions about the prescription occur with the physician (45% indicate several discussions, 40% indicate one or two discussions, and 10% indicate no discussions. In most cases (~75% of the time, allergy prescription refills did not require a doctor visit with patients obtaining refills through phone calls to the doctor’s office or through the pharmacy. Two-thirds of patients (69% report that they have discussed their prescription allergy medication with a pharmacist, with greater than half of respondents having discussed the use of the non-prescription medication with their doctor. Conclusion: Patients with diagnosed allergic rhinitis appear to be self-managing their condition with few interactions with their doctor about their allergy prescription. Interactions with a pharmacist about allergy medication (prescription and non-prescription appear to be more common than interactions with a physician.

  13. Foetal Exposure to Maternal Passive Smoking Is Associated with Childhood Asthma, Allergic Rhinitis, and Eczema

    Science.gov (United States)

    Lee, S. L.; Lam, T. H.; Leung, T. H.; Wong, W. H. S.; Schooling, M.; Leung, G. M.; Lau, Y. L.

    2012-01-01

    Objective. We examined the hypothesis that foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. Methods. The study was a population-based cross-sectional survey of Hong Kong Chinese children aged ≤14 years carried out in 2005 to 2006. Results. Foetal exposure to maternal passive smoking was significantly associated with wheeze ever (OR 2.05; 95% CI 1.58–2.67), current wheeze (OR 2.06; 95% CI 1.48–2.86), allergic rhinitis ever (OR 1.22; 95% CI 1.09–1.37), and eczema ever (OR 1.61; 95% CI 1.38–1.87). Foetal exposure to maternal active smoking was significantly associated with asthma ever (OR 2.10; 95% CI 1.14–3.84), wheeze ever (OR 2.46; 95% CI 1.27–4.78), and current wheeze (OR 2.74; 95% CI 1.24–6.01) but not with allergic rhinitis ever (OR 1.01; 95% CI 0.70–1.46) or eczema ever (OR 1.38; 95% CI 0.87–2.18). The dose response relationship between wheeze ever and current wheeze with increasing exposure, from no exposure to maternal passive smoking and then to maternal active smoking, further supports causality. Conclusion. There is significant association between foetal exposure to maternal passive smoking and maternal active smoking with childhood asthma and related atopic illnesses. Further studies are warranted to explore the potential causal relationship. PMID:22927783

  14. Foetal Exposure to Maternal Passive Smoking Is Associated with Childhood Asthma, Allergic Rhinitis, and Eczema

    Directory of Open Access Journals (Sweden)

    S. L. Lee

    2012-01-01

    Full Text Available Objective. We examined the hypothesis that foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. Methods. The study was a population-based cross-sectional survey of Hong Kong Chinese children aged ≤14 years carried out in 2005 to 2006. Results. Foetal exposure to maternal passive smoking was significantly associated with wheeze ever (OR 2.05; 95% CI 1.58–2.67, current wheeze (OR 2.06; 95% CI 1.48–2.86, allergic rhinitis ever (OR 1.22; 95% CI 1.09–1.37, and eczema ever (OR 1.61; 95% CI 1.38–1.87. Foetal exposure to maternal active smoking was significantly associated with asthma ever (OR 2.10; 95% CI 1.14–3.84, wheeze ever (OR 2.46; 95% CI 1.27–4.78, and current wheeze (OR 2.74; 95% CI 1.24–6.01 but not with allergic rhinitis ever (OR 1.01; 95% CI 0.70–1.46 or eczema ever (OR 1.38; 95% CI 0.87–2.18. The dose response relationship between wheeze ever and current wheeze with increasing exposure, from no exposure to maternal passive smoking and then to maternal active smoking, further supports causality. Conclusion. There is significant association between foetal exposure to maternal passive smoking and maternal active smoking with childhood asthma and related atopic illnesses. Further studies are warranted to explore the potential causal relationship.

  15. Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.

    OpenAIRE

    Lacoeuille Yannick; Botturi Karine; Cavaillès Arnaud; Vervloet Daniel; Magnan Antoine

    2011-01-01

    Abstract Background Th2 cell activation and T regulatory cell (Treg) deficiency are key features of allergy. This applies for asthma and rhinitis. However with a same atopic background, some patients will develop rhinitis and asthma, whereas others will display rhinitis only. Co-receptors are pivotal in determining the type of T cell activation, but their role in allergic asthma and rhinitis has not been explored. Our objective was to assess whether allergen-induced T cell activation differs ...

  16. PRIMARY NOCTURNAL ENURESIS IN CHILDREN WITH ALLERGIC RHINITIS AND SEVERE ADENOTONSILLAR HYPERTROPHY: A SINGLE CENTER PILOT STUDY.

    Science.gov (United States)

    Chimenz, R; Manti, S; Fede, C; Stroscio, G; Visalli, C; Nicotera, A; Di Rosa, G; Romeo, A C; Salpietro, V; Cuppari, C

    2015-01-01

    Nocturnal enuresis is defined as intermittent urinary incontinence during sleep that occurs at least twice a week for three consecutive months. There is no unifying etiology for nocturnal enuresis in the pediatric population and the disorder is likely to be multifactorial. We aimed to investigate the relationship between primary nocturnal enuresis, allergic rhinitis, and related complications in a paediatric case series from a single Center. We retrospectively reviewed and prospectively followed-up at our Institution (i) 32 children (14 females, 18 males; mean age 6.31±1.21 yrs) affected by allergic rhinitis with adenoidal hypertrophygrade I-II (group A) and (ii) 27 children (11 females, 16 males; mean age 6.52±1.33 yrs) affected by allergic rhinitis with adenoidal hypertrophy grade III-IV (group B). Allergic rhinitis was diagnosed on the basis of (a) typical nasal symptoms due to atopic sensitization (e.g., rhinorrhea , itching, sneezing fits, and nasal congestion and obstruction) and (b) positive skin prick testing and/or increased level of total serum IgE. We identified discrepancies between group A and group B in terms of risk of primary nocturnal enuresis. In fact, only 1 child of group A (3.12%) reported uncomplicated primary nocturnal enuresis; conversely, 6 children of group B (22.22%) showed a history of uncomplicated primary nocturnal enuresis (p=0.040). There was no statistically significant difference between the two groups in terms of atopic sensitization and serum total IgE levels (p=0.43). Allergic rhinitis may potentially influence the onset and the natural history of nocturnal enuresis in some children. Children with allergic rhinitis and more severe respiratory manifestations, seem to be more prone to developing primary nocturnal enuresis, likely due to potential multi-factorial causes (e.g., sleep disorders, chronic phlogosis, immune deregulation).

  17. Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis.

    Science.gov (United States)

    Desai, Mauli B; Gavrilova, Tatyana; Liu, Jianjun; Patel, Shyam A; Kartan, Saritha; Greco, Steven J; Capitle, Eugenio; Rameshwar, Pranela

    2013-10-01

    Mesenchymal stem cells (MSCs) are promising cellular suppressor of inflammation. This function of MSCs is partly due to their licensing by inflammatory mediators. In cases with reduced inflammation, MSCs could become immune-enhancer cells. MSCs can suppress the inflammatory response of antigen-challenged lymphocytes from allergic asthma. Although allergic rhinitis (AR) is also an inflammatory response, it is unclear if MSCs can exert similar suppression. This study investigated the immune effects (suppressor vs enhancer) of MSCs on allergen-stimulated lymphocytes from AR subjects (grass or weed allergy). In contrast to subjects with allergic asthma, MSCs caused a significant (Pcells (antigen-presenting cells (APCs)). This correlated with increased production of inflammatory cytokines from T cells, and increased expressions of major histocompatibility complex (MHC)-II and CD86 on MSCs. The specificity of APC function was demonstrated in APC assay using MSCs that were knocked down for the master regulator of MHC-II transcription, CIITA. The difference in the effects of MSCs on allergic asthma and AR could not be explained by the sensitivity to the allergen, based on skin tests. Thus, we deduced that the contrasting immune effects of MSCs for antigen-challenged lymphocytes on AR and allergic asthma could be disease specific. It is possible that the enhanced inflammation from asthma might be required to license the MSCs to become suppressor cells. This study underscores the need for robust preclinical studies to effectively translate MSCs for any inflammatory disorder. PMID:25505949

  18. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

    DEFF Research Database (Denmark)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W;

    2016-01-01

    decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les......The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical...

  19. Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis

    Directory of Open Access Journals (Sweden)

    de Weger Letty A

    2011-12-01

    Full Text Available Abstract Background For the development of forecasts for seasonal allergic rhinitis symptoms, it is essential to understand the relationship between grass pollen concentrations and the symptoms of grass pollen allergic patients. Objective The aim of this study was to delineate this relationship between seasonal allergic rhinitis symptoms and grass pollen concentrations in the Netherlands. Methods Grass pollen allergic patients (n = 80 [2007] - 84 [2008] were enrolled into the study. They were asked to enter their seasonal allergic rhinitis symptoms (runny nose, sneezing, blocked nose, post nasal drip, and eye symptoms daily on a scale from 0 to 3 to the study centre either by short message service (SMS or by internet from May-July 2007 and April-July 2008. Daily pollen counts were used to define the early and the late grass pollen season as the period 'before and during' respectively 'after' the first grass pollen peak (more than 150 pollen/m3. Results At similar grass pollen concentrations, the daily mean of the individual maximum symptom scores reported in the early season were higher as compared to that reported in the late season [differences of -0.41 (2007 and -0.30 (2008]. This difference could not be explained by medication use by the patients nor by co-sensitization to birch. Conclusions We conclude that seasonal allergic rhinitis symptoms at similar grass pollen concentrations are more severe in the early flowering season as compared to those in the late flowering season. This finding is not only relevant for development of forecasts for seasonal allergic rhinitis symptoms but also for understanding symptom development and planning and analysis of clinical studies.

  20. AN OPEN LABEL PILOT STUDY TESTING THE ROLE OF CLASSICAL HOMEOPATHY IN CHRONIC ALLERGIC RHINITIS

    Directory of Open Access Journals (Sweden)

    S. Ghosh*, S. Das, M. Mundle Dishari Sengupta, Sk. Intaj Hossain, M. Koley and S. Saha

    2013-04-01

    Full Text Available ABSTRACT: Purpose: The prevalence of allergic rhinitis (AR is increasing at an alarming rate throughout the world. India has an estimated number of 15-20 million patients with allergic bronchial asthma and 30-80% of these suffer from AR. So, AR is considered as a major chronic respiratory disease due to its prevalence, impact on quality of life (QoL, work/school performance and productivity, economic burden and links with asthma. This research aims at testing the role of classical homeopathy in bringing changes in serum immunoglobulin E (IgE level and absolute eosinophil count (primary outcome measures and symptoms score and WHOQOL-BREF score related to AR (secondary outcome measures by comparing the pre-trial and post-trial data.

  1. Sphenopalatine ganglion stimulation with one acupuncture needle for moderate-severe persistent allergic rhinitis: study protocol for a multicenter randomized controlled trial

    OpenAIRE

    Zhang, Lu; Li, Lei(Beijing Institute of Petrochemical Technology, Beijing, 102617, People's Republic of China); Shi, Da-Zhuo; Chen, Lu-Quan; Zheng, Kai-Min; Cheng, Kai; Tao, Ye; Guo, Hai-yan; Li, Shu-Liang; Liu, Jing; Xu, Feng; Shen, Jian-Wu

    2015-01-01

    Background Allergic rhinitis is a symptomatic allergic disease of the nose that affects 10 to 20% of the global population. Chinese otolaryngologists use one acupuncture needle to stimulate the sphenopalatine ganglion because of its potential advantages for treating moderate-severe persistent allergic rhinitis compared with traditional Chinese acupuncture (verum acupuncture); however, little evidence is available to support the wide clinical use thus far. Therefore, we propose a protocol for ...

  2. Atopic Manifestations: Dermatitis, Allergic Rhinitis and Asthma in Patients With Hypogammaglobulinemia

    Directory of Open Access Journals (Sweden)

    Minoo Dadkhah

    2015-10-01

    Full Text Available Background: Most of the hypogammaglobulinemic patients have a clinical history in favor of allergic respiratory disease. Nevertheless, in these patients the importance and prevalence of atopic disorders have not been completely explained. Objectives: This study was aimed to evaluate atopic manifestations (dermatitis, allergic rhinitis and asthma and pulmonary function in patients with hypogammaglobulinemia. Patients and Methods: We used the international study of asthma and allergies in childhood (ISAAC questionnaire in forty-five patients diagnosed with hypogammaglobulinemia and spirometry was done in 41 patients older than 5 years. Results: Spirometry results were normal in 21 (51%, and showed obstructive in 15 (37% and restrictive pattern in 5 (12% of the 41 patients who were evaluated. By the end of the study, asthma was diagnosed in nine (20% patients and other atopies (rhinitis and dermatitis identified in 10 (22%, and four (9%, respectively. Conclusions: Atopic conditions should be investigated in the hypogammaglobulinemic patients and the prevalence in these patients may be higher than in normal population. Also, it is recommended to perform a pulmonary function test as a routine procedure in patients with hypogammaglobulinemia and atopy should be assessed in these patients.

  3. Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis

    OpenAIRE

    Ekaterina Maslova; Marin Strøm; Sjurdur F Olsen; Halldorsson, Thorhallur I

    2013-01-01

    BACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we admi...

  4. Alleviation and prevention of severe allergic rhinitis and conjunctivitis following long-term lemon juice use: a case report

    OpenAIRE

    Vazouras, Konstantinos GI; Partheniou, Jota; Dimoliatis, Ioannis DK

    2009-01-01

    Allergic rhinitis (often coexisting with allergic conjunctivitis) is a highly prevalent, chronic, inflammatory disease. Most cases are not extraordinary; however, they may result in significant impairment in quality of life of patients, as well as in economical damage for both health-care system and patients. This case report describes the experiences of a middle-aged woman with the illness, who managed to completely alleviate and prevent her symptoms, in terms of intensity and chronicity, by...

  5. Intranasal application of Epstein-Barr virus/lipoplex to abrogate eosinophillia in murine model of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    HAN De-min; ZHOU Bing; WANG Tong; WANG Xiang-dong; FAN Er-zhong

    2006-01-01

    Background Currently anti-inflammatory therapy with steroids for allergic rhinitis need long-term repeated administration, although it is effective. Gene therapy is being suggested to substitute it. The aim of this study was to investigate nonviral vector mediated exogenous gene expression in COS-7 cells in vitro and the effect of intranasal mouse interleukin (mIL)-12 transgene expression on allergen induced eosinophil infiltration of nasal mucosa in a murine model of allergic rhinitis.Methods In vitro COS-7 cells were infected with Epstein-Barr virus (EBV)/lipoplex. The expression of IL-12 p70 in cell culture supernatant was examined by enzyme-linked immunosorbent assay (ELISA). In mice with ovalbumin (OVA) induced allergic rhinitis, EBV/lipoplex was administered by nasal drops before OVA challenge once a day from day 1 to day 10. The expression of IL-12 mRNA and protein, the change of eosinophil count in nasal mucosa and serum total IgE were measured 24 hours after the last challenge.Results EBV/lipoplex could effectively transfect COS-7 cells. The expression of IL-12 p70 in cell culture supernatant was significantly more than in blank control. IL-12 via EBV plasmid vector transduction could be overexpressed in vivo. In pGEG.mIL-12 treated models, the nasal mucosa revealed a high level of widespread mIL-12 transduction by immunohistochemistry and in situ hybridization. Histological evaluation revealed marked suppression of eosinophil infiltration in nasal mucosa. The eosinophil count in allergic rhinitis group [(26.5±9.8)/high-power field (HPF)] was significantly increased over control group [(0.40±0.52)/HPF](F=56.94, P<0.01), while the count in IL-12 gene therapy group [(4.60±2.63)/HPF] was significantly less than that of allergic group (F=56.9, P<0.01). Serum total IgE between in gene therapy mice [(88.83±6.71) ng/ml]and allergic rhinitis mice [(103.1 ± 5.7) ng/ml] showed a significant difference (F=1216, P<0.05).Conclusions Nonviral EBV plasmid

  6. How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement

    DEFF Research Database (Denmark)

    Bousquet, J; Schünemann, H J; Bousquet, P J;

    2011-01-01

    Specific immunotherapy (SIT) is one of the treatments for allergic rhinitis. However, for allergists, nonspecialists, regulators, payers, and patients, there remain gaps in understanding the evaluation of randomized controlled trials (RCTs). Although treating the same diseases, RCTs in SIT and ph...

  7. Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa

    NARCIS (Netherlands)

    G.J. Braunstahl (Gert-Jan); S.E. Overbeek (Shelley); W.J. Fokkens (Wytske); A. Kleinjan (Alex); A.R. McEuen; A.F. Walls; H.C. Hoogsteden (Henk); J-B. Prins (Jan-Bas)

    2001-01-01

    textabstractMast cells and basophils are cells that play an important role in the initiation and control of allergic inflammation in asthma and rhinitis. This study was undertaken to determine the presence and dynamics of mast cells and basophils in the nasal and bronchial mucosa o

  8. Paediatric rhinitis

    DEFF Research Database (Denmark)

    Roberts, G; Xatzipsalti, M; Borrego, L M;

    2013-01-01

    conditions such as adenoidal hypertrophy, septal deviation and nasal polyps. Examination by anterior rhinoscopy and allergy tests may help to substantiate a diagnosis of allergic rhinitis. Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). Oral and intranasal antihistamines and nasal...

  9. Clara cell protein in nasal lavage fluid and nasal nitric oxide - biomarkers with anti-inflammatory properties in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Irander Kristina

    2012-02-01

    Full Text Available Abstract Background Clara cell protein (CC16 is ascribed a protective and anti-inflammatory role in airway inflammation. Lower levels have been observed in asthmatic subjects as well as in subjects with intermittent allergic rhinitis than in healthy controls. Nasal nitric oxide (nNO is present in high concentrations in the upper airways, and considered a biomarker with beneficial effects, due to inhibition of bacteria and viruses along with stimulation of ciliary motility. The aim of this study was to evaluate the presumed anti-inflammatory effects of nasal CC16 and nNO in subjects with allergic rhinitis. Methods The levels of CC16 in nasal lavage fluids, achieved from subjects with persistent allergic rhinitis (n = 13, intermittent allergic rhinitis in an allergen free interval (n = 5 and healthy controls (n = 7, were analyzed by Western blot. The levels of nNO were measured by the subtraction method using NIOX®. The occurrences of effector cells in allergic inflammation, i.e. metachromatic cells (MC, mast cells and basophiles and eosinophils (Eos were analyzed by light microscopy in samples achieved by nasal brushing. Results The levels of CC16 correlated with nNO levels (r2 = 0.37; p = 0.02 in allergic subjects. The levels of both biomarkers showed inverse relationships with MC occurrence, as higher levels of CC16 (p = 0.03 and nNO (p = 0.05 were found in allergic subjects with no demonstrable MC compared to the levels in subjects with demonstrable MC. Similar relationships, but not reaching significance, were observed between the CC16 and nNO levels and Eos occurrence. The levels of CC16 and nNO did not differ between the allergic and the control groups. Conclusions The correlation between nasal CC16 and nNO levels in patients with allergic rhinitis, along with an inverse relationship between their levels and the occurrences of MC in allergic inflammation, may indicate that both biomarkers have anti-inflammatory effects by suppression of

  10. Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4

    Directory of Open Access Journals (Sweden)

    Lacoeuille Yannick

    2011-02-01

    Full Text Available Abstract Background Th2 cell activation and T regulatory cell (Treg deficiency are key features of allergy. This applies for asthma and rhinitis. However with a same atopic background, some patients will develop rhinitis and asthma, whereas others will display rhinitis only. Co-receptors are pivotal in determining the type of T cell activation, but their role in allergic asthma and rhinitis has not been explored. Our objective was to assess whether allergen-induced T cell activation differs from allergic rhinitis to allergic rhinitis with asthma, and explore the role of ICOS, CD28 and CTLA-4. Methods T cell co-receptor and cytokine expressions were assessed by flow cytometry in PBMC from 18 house dust mite (HDM allergic rhinitics (R, 18 HDM allergic rhinitics and asthmatics (AR, 13 non allergic asthmatics (A and 20 controls, with or without anti-co-receptors antibodies. Results In asthmatics (A+AR, a constitutive decrease of CTLA-4+ and of CD4+CD25+Foxp3+ cells was found, with an increase of IFN-γ+ cells. In allergic subjects (R + AR, allergen stimulation induced CD28 together with IL-4 and IL-13, and decreased the proportion of CTLA-4+, IL-10+ and CD4+CD25+Foxp3+ cells. Anti-ICOS and anti-CD28 antibodies blocked allergen-induced IL-4 and IL-13. IL-13 production also involved CTLA-4. Conclusions T cell activation differs between allergic rhinitis and asthma. In asthma, a constitutive, co-receptor independent, Th1 activation and Treg deficiency is found. In allergic rhinitis, an allergen-induced Treg cell deficiency is seen, as well as an ICOS-, CD28- and CTLA-4-dependent Th2 activation. Allergic asthmatics display both characteristics.

  11. Vitamin D Deficiency and Allergic Rhinitis in Children: A Narrative Review

    Directory of Open Access Journals (Sweden)

    Javad Ghaffari

    2015-07-01

    Full Text Available Context: Allergic diseases such as allergic rhinitis (AR and immune-mediated inflammatory diseases are the most common chronic diseases among children. Although the cause of AR has yet to be clearly identified, genetic and environmental factors are known to play an important role in the development of the disease. Evidence Acquisition: In a more recent classification, AR is categorized as intermittent and permanent. Vitamin D has a known and important role in the absorption of calcium and preservation of bone density. The prevalence of vitamin D deficiency in children is reported to be between 30% and 50% in the world. Vitamin D confers the growth and development of the immune system including the development of regulatory T cells. Results: Two-thirds of the reviewed articles show a correlation between serum levels of vitamin D and allergic diseases, while the reaming ones demonstrate no correlation between vitamin D and AR and some even report a rise in the incidence of AR following the use of vitamin D supplement. Conclusions: It seems that further clinical trials and meta-analytic studies are necessary to confirm this correlation. The present study aimed at reviewing vitamin D deficiency in children with AR.

  12. Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis.

    Science.gov (United States)

    He, Miao; Inoue, Ken-Ichiro; Yoshida, Seiichi; Tanaka, Michitaka; Takano, Hirohisa; Sun, Guifan; Ichinose, Takamichi

    2013-06-01

    Recent epidemiological studies have suggested a positive link between atopy morbidity and exposure to phthalate esters, which are environmental chemicals mainly involved in house dust. Nevertheless, experimental studies applying several allergic in vivo models (in addition to epidemiological studies) are needed to prove the precise correlation between phthalates and facilitation of the allergic response/pathophysiology. Among the phthalate esters, di-(2-ethylhexyl) phthalate (DEHP) has been widely used in flexible polyvinyl chloride products, including vinyl flooring and wall covering, and has been widely suggested to have immunomodulating potential. In the present study, we examined the effects of airway exposure to DEHP on allergen (ovalbumin: OVA)-induced rhinitis in mice. The repeated administration of OVA via an intranasal route induced nasal inflammation characterized by the infiltration of granulocytes (neutrophils and eosinophils) into the nasal cavity. In this experimental setting, DEHP did not exaggerate OVA-related inflammatory pathology. However, local (nasal) IL-13 levels were significantly higher in mice treated with allergen plus DEHP than with allergen alone. Taken together, phthalate esters including DEHP have the potential to exacerbate the allergic milieu in the nasal system, as well as dermal and respiratory systems. PMID:23672524

  13. Expression of Toll-like receptors in nasal epithelium in allergic rhinitis.

    Science.gov (United States)

    Renkonen, Jutta; Toppila-Salmi, Sanna; Joenväärä, Sakari; Mattila, Pirkko; Parviainen, Ville; Hagström, Jaana; Haglund, Caj; Lehtonen, Mikko; Renkonen, Risto

    2015-08-01

    Toll-like receptors (TLRs) are important in barrier homeostasis, but their role in airborne allergies is not fully understood. The aim was to evaluate baseline and allergen-induced expression of TLR proteins in nasal epithelium during allergic rhinitis. Nineteen otherwise healthy non-smoking volunteers both allergic to birch pollen and non-allergic controls were enrolled. We took nasal biopsies before and after off-seasonal intranasal birch pollen or diluent challenge. The expression of epithelial TLR1-7, TLR9-10, and MyD88 proteins was immunohistochemically evaluated from the nasal biopsies. The TLR1-3 and TLR5-10 mRNAs were observed by RNA-microarray. Baseline epithelial expression of TLR proteins was wide and identical in controls and atopics. After off-seasonal intranasal birch pollen challenge, a negative change in the expression score of TLR1 and TLR6 proteins was detected in the atopic group. TLR mRNA expression was not affected by birch pollen challenge. Nasal epithelium seems to express all known TLRs. The mechanisms by which TLR1, and TLR6 proteins could affect pollen allergen transport need further studies.

  14. Allergic Rhinitis

    Science.gov (United States)

    ... mulches, commercial peat moss, compost piles and leaf litter. This allergy is usually worse during humid and ... use mattress pads. Cover mattress and pillows with plastic covers. Lower the humidity in your home using ...

  15. Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin.

    Science.gov (United States)

    Lacroix, J S; Buvelot, J M; Polla, B S; Lundberg, J M

    1991-09-01

    Sixteen adult patients suffering from severe chronic non-allergic rhinitis with nasal vasoconstrictor abuse for more than a year, received, under local anaesthesia, an intranasal spray of capsaicin (3.3 x 10(-3) mol), the pungent agent in hot pepper, once weekly for 5 weeks. The subjective intensity of their nasal obstruction, rhinorrhoea and sneezing frequency were evaluated throughout the study and the vascular effects of capsaicin on the nasal mucosa were recorded by anterior rhinomanometry and laser Doppler flowmetry. Calcitonin gene-related peptide (CGRP) is a vasodilator agent present in sensory nerves and may play a major role in the vascular component of neurogenic inflammation. Therefore, the nasal mucosa content of CGRP-like immunoreactivity (CGRP-LI) was determined by radioimmunoassay in biopsies obtained before and after the capsaicin treatment. Intra-nasal capsaicin application evoked a larger vascular response in patients with rhinitis than in controls (P less than 0.05). Both nasal vascular responses and subjective discomfort following capsaicin were markedly reduced after the fifth application (P less than 0.01). In parallel, a 50% reduction of the CGRP-LI content in the nasal biopsies was observed. All symptoms were significantly improved throughout a 6 month follow-up period. No significant side-effects occurred and weaning from nasal vasoconstrictor agents was possible. Both the subjective symptom score and objective measurements of vascular reactivity suggest that repeated intra-nasal capsaicin application could be beneficial for patients with chronic rhinitis, possibly by reducing hyperreactive nasal reflexes. PMID:1742652

  16. UK prescribing practices as proxy markers of unmet need in allergic rhinitis: a retrospective observational study

    Science.gov (United States)

    Price, David B; Scadding, Glenis; Bachert, Claus; Saleh, Hesham; Nasser, Shuaib; Carter, Victoria; von Ziegenweidt, Julie; Durieux, Alice M S; Ryan, Dermot

    2016-01-01

    Little data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database. We assessed diagnoses and prescription data for patients with a recorded diagnosis of rhinitis who took rhinitis medication during the study period. We assessed the data from 25,069 patients in 2009 and 22,381 patients in 2010. Monotherapy was the initial prescription of the season for 67% of patients with seasonal AR (SAR) and 77% of patients with nonseasonal upper airways disease (NSUAD), for both years. Initial oral antihistamine (OAH) or intranasal corticosteroid (INS) monotherapy proved insufficient for >20% of SAR and >37% of NSUAD patients. Multiple therapy was the initial prescription for 33% of SAR and 23% of NSUAD in both years, rising to 45% and >50% by season end, respectively. For NSUAD, dual-therapy prescriptions doubled and triple-therapy prescriptions almost tripled during both seasons. Many patients revisited their GP regardless of initial prescription. Initial OAH or INS monotherapy provides insufficient symptom control for many AR patients. GPs often prescribe multiple therapies at the start of the season, with co-prescription becoming more common as the season progresses. However, patients prescribed multiple therapies frequently revisit their GP, presumably to adjust treatment. These data suggest the need for more effective AR treatment and management strategies. PMID:27334893

  17. UK prescribing practices as proxy markers of unmet need in allergic rhinitis: a retrospective observational study.

    Science.gov (United States)

    Price, David B; Scadding, Glenis; Bachert, Claus; Saleh, Hesham; Nasser, Shuaib; Carter, Victoria; von Ziegenweidt, Julie; Durieux, Alice M S; Ryan, Dermot

    2016-01-01

    Little data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database. We assessed diagnoses and prescription data for patients with a recorded diagnosis of rhinitis who took rhinitis medication during the study period. We assessed the data from 25,069 patients in 2009 and 22,381 patients in 2010. Monotherapy was the initial prescription of the season for 67% of patients with seasonal AR (SAR) and 77% of patients with nonseasonal upper airways disease (NSUAD), for both years. Initial oral antihistamine (OAH) or intranasal corticosteroid (INS) monotherapy proved insufficient for >20% of SAR and >37% of NSUAD patients. Multiple therapy was the initial prescription for 33% of SAR and 23% of NSUAD in both years, rising to 45% and >50% by season end, respectively. For NSUAD, dual-therapy prescriptions doubled and triple-therapy prescriptions almost tripled during both seasons. Many patients revisited their GP regardless of initial prescription. Initial OAH or INS monotherapy provides insufficient symptom control for many AR patients. GPs often prescribe multiple therapies at the start of the season, with co-prescription becoming more common as the season progresses. However, patients prescribed multiple therapies frequently revisit their GP, presumably to adjust treatment. These data suggest the need for more effective AR treatment and management strategies. PMID:27334893

  18. Expression of HSP70 in Peripheral Lymphocytes of the Patients with Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    刘立思; 肖成峰; 张明; 程磊; 王鄂芬; 邬堂春

    2003-01-01

    The expression levels of heat shock protein 70 (HSP70) from peripheral lymphocytes ofthe patients with allergic rhinitis (AR) and the clinical implication were investigated. In the morn-ing, 3 ml of fasting venous blood was taken out. The lymphocytes were isolated by using Ficoll-Hypaque and the expression of HSP70 in the lymphocytes was detected by using Western blot. Inthe AR patients the HSP70 level (41.49± 15.77 integrated optical density, IOD) were significantlyhigher than that in the control group (23.89±10. 13 IOD, P<0.05). Western blot demonstratedthat HSP70 bands in AR patients were more intensive than those in the control group. It was con-cluded that the elevated HSP70 level in peripheral lymphocytes of the AR patients might contributeto the development of AR.

  19. Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial.

    Science.gov (United States)

    Choi, Seo Yeon; Park, Kyungsook

    2016-01-01

    This study aimed to investigate the effects of aromatherapy oil inhalation on symptoms, quality of life, sleep quality, and fatigue level among adults with perennial allergic rhinitis (PAR). Fifty-four men and women aged between 20 and 60 were randomized to inhale aromatherapy oil containing essential oil from sandalwood, geranium, and Ravensara or almond oil (the placebo) for 5 minutes twice daily for 7 days. PAR symptoms determined by Total Nasal Symptom Score (TNSS), the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), sleep quality by Verran Synder-Halpern (VSH) scale, and fatigue level by Chalder Fatigue Scale (CFS) were assessed before and after intervention period. Compared with the placebo, the experimental group showed significant improvement in TNSS, especially in nasal obstruction. The aromatherapy group also showed significantly higher improvements in total score of RQLQ and CFS. These findings indicate that inhalation of certain aromatherapy oil helps relieve PAR symptoms, improve rhinitis-specific quality of life, and reduce fatigue in patients with PAR. In conclusion, inhalation of aromatherapy essential oil may have potential as an effective intervention to alleviate PAR. PMID:27034695

  20. Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Seo Yeon Choi

    2016-01-01

    Full Text Available This study aimed to investigate the effects of aromatherapy oil inhalation on symptoms, quality of life, sleep quality, and fatigue level among adults with perennial allergic rhinitis (PAR. Fifty-four men and women aged between 20 and 60 were randomized to inhale aromatherapy oil containing essential oil from sandalwood, geranium, and Ravensara or almond oil (the placebo for 5 minutes twice daily for 7 days. PAR symptoms determined by Total Nasal Symptom Score (TNSS, the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ, sleep quality by Verran Synder-Halpern (VSH scale, and fatigue level by Chalder Fatigue Scale (CFS were assessed before and after intervention period. Compared with the placebo, the experimental group showed significant improvement in TNSS, especially in nasal obstruction. The aromatherapy group also showed significantly higher improvements in total score of RQLQ and CFS. These findings indicate that inhalation of certain aromatherapy oil helps relieve PAR symptoms, improve rhinitis-specific quality of life, and reduce fatigue in patients with PAR. In conclusion, inhalation of aromatherapy essential oil may have potential as an effective intervention to alleviate PAR.

  1. The burden of allergic rhinitis (AR in Canada: perspectives of physicians and patients

    Directory of Open Access Journals (Sweden)

    Keith Paul K

    2012-06-01

    Full Text Available Abstract Background Allergic rhinitis (AR is a common problem and we sought to examine the burden of disease and its management in Canada from the perspectives of patients and physicians. Methods Two parallel, Canadawide structured telephone interviews surveyed 1,001 AR patients and 160 physicians in July 2006. Results 44% of patients had experienced nasal symptoms unrelated to a cold and 20% had a physician diagnosis of AR. At screening 27% reported asthma, 15% chronic or recurrent sinusitis and 5% nasal polyps. With attacks nasal congestion and runny nose were the most bothersome symptoms. Other problems experienced were fatigue (46%, poor concentration (32%, and reduced productivity (23%. Most (77% had not seen a physician in the past year. Physicians estimated they prescribed intranasal cortico steroids (INCS to most AR patients (77% consistent with guidelines but only 19% of patients had used one in the last month. Only 48% of patients were very satisfied with their current INCS. 41% of AR patients reported discontinuing their INCS with the most common reason being a perceived lack of long-lasting symptom relief (44%. 52% of patients felt that their current INCS lost effectiveness over 24 h. The most common INCS side effects included dripping down the throat, bad taste, and dryness. Most AR patients reported lifestyle limitations despite treatment (66%. 61% of patients felt that their symptoms were only somewhat controlled or poorly/not controlled during their worst month in the past year. Conclusions AR symptoms are common and many patients experience inadequate control. Physicians report they commonly prescribe intranasal corticosteroids, but patient’s perceived loss of efficacy and side effects lead to their discontinuation. Persistent relief of allergic rhinitis symptoms remains a major unmet need. Better treatments and education are required.

  2. Risk of Allergic Rhinitis, Allergic Conjunctivitis, and Eczema in Children Born to Mothers with Gum Inflammation during Pregnancy

    Science.gov (United States)

    Hsieh, Vivian Chia-Rong; Liu, Chin-Chen; Hsiao, Yu-Chen; Wu, Trong-Neng

    2016-01-01

    Purpose Despite links between maternal and child health status, evidence on the association between gum infection in pregnant mothers and childhood allergies is scarce. We aim to evaluate the risk of developing allergy in children born to periodontal mothers in a nationwide study. Methods We conducted a 9-year population-based, retrospective cohort study using Taiwan’s National Health Insurance database. A study cohort of 42,217 newborns born to mothers with periodontal disease during pregnancy was identified in 2001 and matched with 42,334 babies born to mothers without any infection (control) by mother’s age at delivery and baby sex. With a follow-up period from 2001 to 2010, we observed the incidence of allergic rhinitis (AR), allergic conjunctivitis (AC), and eczema in these children. Cox proportional hazards regression models were performed with premature deaths as competing risk for the estimation of allergic disease risks. Results Nine-year cumulative incidences were the highest among children born to periodontal mothers; they reached 46.8%, 24.2%, and 40.4% (vs. 39.5%, 18.3% and 34.8% in control) for AR, AC, and eczema, respectively. Our results showed moderately increased risks for the allergies in children born to periodontal mothers relative to their matched non-inflammatory control (adjusted HRs: 1.17, 95% CI: 1.15–1.20; 1.27, 1.24–1.31; 1.14, 1.12–1.17, respectively). Because the impact of food consumption and living environment cannot be considered using insurance data, we attempted to control it by adjusting for parental income and mother’s residential area. Conclusions Overall cumulative incidence and risks of children born to periodontal mothers for AR, AC, and eczema are significantly higher than those born to non-inflammatory mothers. Gum infection in women during pregnancy is an independent risk factor for allergic diseases in children, thus its intergenerational consequences should be considered in gestational care. PMID:27224053

  3. Study on Cytokines IL-2, IL-6, IL-10 in Patients of Chronic Allergic Rhinitis Treated with Acupuncture

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objectives: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. Methods: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). Results: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P<0.05). On the other hand, in those patients treated with sham acupuncture (B2) as well as in non-treated patients (B3), the IL-10 values remained high and unchanged. There was a statistically significant change in IL-2 values at 24 hours (P<0.05) after real acupuncture (Groups A, B1), however the values remained within normal ranges. The IL-6 do not change after therapy. Conclusion: The acupuncture treatment can reduce plasmatic level of IL-10 in chronic allergic rhinitis.

  4. Responses of Six-Weeks Aquatic Exercise on the Autonomic Nervous System, Peak Nasal Inspiratory Flow and Lung Functions in Young Adults with Allergic Rhinitis

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    Taweesak Janyacharoen

    2015-10-01

    Full Text Available Allergic rhinitis is a chronic respiratory disease. Sympathetic hypofunction is identified in all of the allergic rhinitis patients. Moreover, allergic rhinitis is associated with decreased peak nasal inspiratory flow (PNIF and impaired lung functions. The aim of this study was to investigate effects of six-week of aquatic exercise on the autonomic nervous system function, PNIF and lung functions in allergic rhinitis patients.Twenty-six allergic rhinitis patients, 12 males and 14 females were recruited in this study. Subjects were diagnosed by a physician based on history, physical examination, and positive reaction to a skin prick test. Subjects were randomly assigned to two groups. The control allergic rhinitis group received education and maintained normal life. The aquatic group performed aquatic exercise for 30 minutes a day, three days a week for six weeks. Heart rate variability, PNIF and lung functions were measured at the beginning, after three weeks and six weeks.There were statistically significant increased low frequency normal units (LF n.u., PNIF and showed decreased high frequency normal units (HF n.u. at six weeks after aquatic exercise compared with the control group.Six weeks of aquatic exercise could increase sympathetic activity and PNIF in allergicrhinitis patients.

  5. Correlation between Serum Osteopontin and miR-181a Levels in Allergic Rhinitis Children

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    Wenlong Liu

    2016-01-01

    Full Text Available Background. Osteopontin (OPN has been proved to be associated with allergic airway inflammation. However, the roles of OPN and its regulation in childhood allergic rhinitis (AR are poorly understood. Objective. This study aims to evaluate the expression of OPN and miR-181a in children with AR and their association with Th1/Th2 immune response. Methods. Children who suffered from AR were included along with control subjects. Serum was collected to examine the level of OPN and Th1/Th2 cytokines by enzyme-linked immunosorbent assay (ELISA and the level of miR-181a by quantitative polymerase chain reaction (qPCR. Results. Children with AR had significantly higher serum levels of OPN and lower serum levels of miR-181a than healthy controls. Furthermore, serum levels of OPN were positively correlated with Th2 cytokine and negatively correlated with Th1 cytokine. On the contrary, miR-181a level had a negative correlation with IL-4/IL-5 and positive correlation with IFN-γ/IL-12. More importantly, there was also significant negative correlation between OPN and miR-181a. Conclusion. The OPN protein and miR-181a levels may serve as predictors of disease severity in childhood AR and appear to be promising targets for modulating AR.

  6. Antioxidant Status and Immune Activity of Glycyrrhizin in Allergic Rhinitis Mice

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    Wei-Jun Chen

    2011-01-01

    Full Text Available Oxidative stress is considered as a major risk factor that contributes to increased lipid peroxidation and declined antioxidants in some degenerative diseases. Glycyrrhizin is widely used to cure allergic diseases due to its medicinal properties. In the present study, we evaluated the role of glycyrrhizin on lipid peroxidation and antioxidant status in the blood and nasal mucosa of allergic rhinitis (AR mice. Mice were divided into six groups: normal control mice, model control (MC mice, three glycyrrhizin-treated mice groups and lycopene-treated mice. Sensitization-associated increase in lipid peroxidation was observed in the blood and nasal mucosa of MC mice. Activities of antioxidant enzymes like superoxide dismutase (SOD, catalase (CAT, glutathione peroxidase (GSH-Px, total antioxidant capacity (TAOC and levels of glutathione (GSH were found to be significantly decreased in the blood and nasal mucosa in MC mice when compared to normal control mice. However, normalized lipid peroxidation and antioxidant defenses were reported in the glycyrrhizin-treated and lycopene-treated mice. Moreover, glycyrrhizin treatment still enhanced IFN-γ and reduced IL-4 levels in glycyrrhizin-treated mice. These findings demonstrated that glycyrrhizin treatment enhanced the antioxidant status and decreased the incidence of free radical-induced lipid peroxidation and improved immunity activities in the blood and nasal mucosa of AR mice.

  7. The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model

    OpenAIRE

    Kim, Boo-Young; Park, Hyang Rim; Shin, Ji-Hyeon; Kim, Sung Won; Cho, Jin Hee; Park, Yong Jin; Kim, Soo Whan

    2014-01-01

    Purpose Serine protease inhibitors are involved in immune development, anti-inflammatory mechanisms, and tissue repair. In the present study, the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride (AEBSF) was evaluated for its prophylactic and therapeutic applications in a mouse model of allergic rhinitis (AR). Methods BALB/c mice were divided into 5 groups: contol (CON), Dermatophagoides farinae (Derf), AR mice treated with AEBSF before sensitization (S), AR m...

  8. Atopic dermatitis, asthma and allergic rhinitis in general practice and the open population: a systematic review

    Science.gov (United States)

    Pols, D. H. J.; Wartna, J. B.; Moed, H.; van Alphen, E. I.; Bohnen, A. M.; Bindels, P. J. E.

    2016-01-01

    Objective To examine whether significant differences exist between the self-reported prevalence of atopic disorders in the open population compared with physician diagnosed prevalence of atopic disorders in general practice. Methods Medline (OvidSP), PubMed Publisher, EMBASE, Google Scholar and the Cochrane Controlled Clinical Trials Register databases were systematically reviewed for articles providing data on the prevalence of asthma, allergic rhinitis and eczema in a GP setting. Studies were only included when they had a cross-sectional or cohort design and included more than 100 children (aged 0-18 years) in a general practice setting. All ISAAC studies (i.e. the open population) that geographically matched a study selected from the first search, were also included. A quality assessment was conducted. The primary outcome measures were prevalence of eczema, asthma and allergic rhinitis in children aged 0-18 years. Results The overall quality of the included studies was good. The annual and lifetime prevalences of the atopic disorders varied greatly in both general practice and the open population. On average, the prevalence of atopic disorders was higher in the open population. Conclusion There are significant differences between the self-reported prevalence of atopic disorders in the open population compared with physician diagnosed prevalence of atopic disorders in general practice. Data obtained in the open population cannot simply be extrapolated to the general practice setting. This should be taken into account when considering a research topic or requirements for policy development. GPs should be aware of the possible misclassification of allergic disorders in their practice. Key PointsEpidemiological data on atopic disorders in children can be obtained from various sources, each having its own advantages and limitations.On average, the prevalence of atopic disorders is higher in the open population.GPs should take into account the possible

  9. Mechanism of traditional Chinese medicine in the treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    GUO Hong; LIU Ming-ping

    2013-01-01

    Objective To review the major progress in mechanism of traditional Chinese medicine (TCM) in the treatment of allergic rhinitis (AR).Methods Contents about the treatment mechanism of TCM in the therapy of AR in this article were obtained from 22 original articles and reviews published in Chinese-and English-language journals.All of the references were searched by use of Pubmed (1997-2012).Results AR is one of the most common and most serious public health problems in children and young people.Many AR patients were worried about the possible adverse effects of synthetic drugs they were taking.Thus,they seek complementary and alternative therapy,such as TCM.TCM emphasized on the importance of holistic convalescence,not just the disease itself.The favorable safety profile of TCM makes well-acceptance by the general population.In the recent decade,more and more studies of TCM for AR are developed.These studies indicated that the treatment of allergic disorders with TCM therapy including herbal medicines and acupuncture are of safety and efficacy.The mechanism of TCM in the treatment of AR has been discussed.It has been reported that a number of the herbs in the Chinese herbal formulae used in the treatment possess anti-allergic,anti-inflammatory or immune modulation activity.Such function include the inhibition of the release or the activity of mast cell mediators (such as histamine),inhibition the induction of inflammation reaction by chemical agents,and down regulation of serum (immunoglobulin E) IgE levels or the activity of lymphocyte and/or macrophage.Conclusions TCM are frequently used concurrently to improve the clinical efficacy.This review is focuses on the description of the actions mechanism of Chinese medicine's approach relevant to the treatment of AR.

  10. Modulation of immune tolerance with a Chinese traditional prescription inhibits allergic rhinitis in mice

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    Min-Qiang Xie

    2011-01-01

    Full Text Available Background : Allergic diseases substantially affect human health and social economy. The pathogenesis is to be further understood. The effect of current therapeutic remedies on allergic diseases is not satisfactory. Aims : This study aimed to inhibit allergic rhinitis in a mouse model with a Chinese traditional medical prescription, Bu-Zhong-Yi-Qi-Tang. Material and Methods : A mouse AR model was developed with ovalbumin (OVA plus adjuvant alum. The AR clinical symptoms and immune pathology in the nasal mucosa were assessed with the AR mouse model. Some mice were treated with Bu-Zhong-Yi-Qi-Tang via gavage-fed. The immune tolerance status in the nasal mucosa was evaluated by counting the numbers of tolerogenic dendritic cells (DC and regulatory T cells (Treg. Results : After exposure to the specific antigen, OVA, the sensitized mice had AR-like symptoms including nasal itch and sneeze. The frequency of mast cells, levels of IgE/IL-4 in nasal mucosa was markedly higher in sensitized mice than naïve controls; while the levels of integration alphavbeta6 (avb6, the number of tolerogenic DCs and Tregs in nasal mucosa were significantly lower than naïve control mice. The AR-like symptoms and immune pathology and immune tolerance status in the AR nasal mucosa were substantially improved by administration with Bu-Zhong-Yi-Qi-Tang. Conclusions : The immune tolerance status is impaired in the AR nasal mucosa that can be improved by administering with Bu-Zhong-Yi-Qi-Tang.

  11. Reflux, Allergic Rhinitis, and Sleep Disorders with Asthma Control and Quality of Life

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    Esat Hayat

    2013-10-01

    Full Text Available Aim: In this study we aimed to investigate the effect of comorbid diseases such as gastroesophageal reflux, allergic rhinitis, sleep disorders with asthma control test and asthma quality of life in Turkish asthma patients. Material and Method: Total of 50 patients who were followed with a diagnosis of asthma were enrolled in this study. During application, spirometric parameters, Reflux Symptom Index (RSI, Allergic Rhinoconjunctivitis Symptom Index (ARSI, Pittsburgh Sleep Quality Index (PSQI, Asthma Control Test (ACT, and Asthma Quality of Life Questionnaires (AQLQ were filled under the supervision of a physician, also smoking habits, body mass index of cases were recorded. The relation of spirometric parameters, RSI, ARSI and PSQI with AQLQ and ACT tests were investigated by using SPSS 15.0 statistical software. Results: Negative correlation was found between the ACT and RSI (r = - 0.314, p = 0.026, ACT and PSQI (r= -0,620; p<0.001. Positive correlation was found between ACT and AQLQ (r=0.667, p <0.001, there was no relationship between ACT and ARSI (p=0,25. Negative correlation was found between AQLQ and RSI (r= -0,551; p<0.001, AQLQ and ARSI (r= -0,390; p<0.005. There was no relationship between AQLQ and PSQI (p=0.082, also there was no relationship between FEV1 value and ACT, AQLQ, RSI, ARSI, PSQI. Discussion: In conclusion, gastroesophageal reflux and allergic rhinoconjunctivitis negatively effect the quality of life and asthma control in asthmatic patients, also poor sleep quality is associated with poor asthma control.

  12. ASSOCIATION BETWEEN SMOKING AND ALLERGIC RHINITIS IN OTOLARYNGOLOGIC PATIENTS OF THE HOSPITAL UNIVERSITARIO DEL CARIBE. CARTAGENA. COLOMBIA. (IN SPANISH

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    Morales-Valdés Lady Johana

    2014-06-01

    Full Text Available Introduction: the allergic rhinitis (AR is a public health problem and the smoking continues having important prevalence in spite of numerous measures applied worldwide. Objective: to estimate the association between smoking and AR. Methods: analytic study, of cases and controls, in which the cases were patients with AR and the control ones, patients with other diseases of the high respiratory way non-related with the rhinitis. It was carried out in the Hospital Universitario del Caribe, Cartagena, Colombia. Data obtained in the surveys were analyzed. The OR with its respective confidence intervals of 95% were used to calculate the association between smoking and AR. Covariates were adjusted by means of a multivariable logistic regression. A P<0.05 was considered statistically significant. Results: 53 cases and 140 controls were included. There were not found statistically significant differences in the socio-demographic variables between cases and controls. The association between active smokers and AR had OR adjusted by confusion variables of 1.02 (CI 95%, 0.25-4.24. Conclusion: there was not found association between smoking and AR. Rev.cienc. biomed. 2014;5(2:205-210. KEYWORDS Rhinitis, Perennial allergic rhinitis, Smoking.

  13. Rhinitis in Older Adults

    OpenAIRE

    Nyenhuis, Sharmilee; Mathur, Sameer K.

    2013-01-01

    Rhinitis symptoms of rhinorrhea, congestion, sneezing, nasal/ocular pruritis, and postnasal drainage can significantly affect the quality of life for older adults. As the US population ages, it will be increasingly important for healthcare providers to effectively diagnose and manage rhinitis. Rhinitis is categorized broadly into allergic rhinitis and non-allergic rhinitis. Environmental changes and avoidance measures are a primary means of intervention. In addition, there are several topical...

  14. 151 International Survey on the Management of Allergic Rhinitis by Physicians and Patients (ISMAR): The Patients' View

    OpenAIRE

    Teijeiro, Alvaro; Badellino, H. A.; Gomez, R. M.; Zernotti, Mario; Croce, J. S.; Murrieta-Aguttes, M.; Baena-Cagnani, Carlos E.

    2012-01-01

    Background Allergic Rhinitis (AR) is a worldwide spread illness and has an important impact on social life, sleep quality, school and work productivity and huge direct and indirect costs. Patient preference is becoming an important aspect in medical care. ISMAR was designed as the first-over global survey to identify differences in attitudes and preference in patients and physicians about AR. This study shows the patient's view. Methods ISMAR is an international, multicenter, non-intervention...

  15. Allergic rhinitis, feeding and oral habits, toothbrushing and socioeconomic status. Effects on development of dental caries in primary dentition.

    Science.gov (United States)

    Vázquez-Nava, F; Vázquez, R E M; Saldivar, G A H; Beltrán, G F J; Almeida, A V M; Vázquez, R C F

    2008-01-01

    The aim was to determine the effect of feeding and oral habits, toothbrushing, socioeconomic status and allergic rhinitis on the development of dental caries in primary dentition. In a cross-sectional study, data were obtained by means of a structured questionnaire on 1,160 children, 4-5 years old (mean = 4.5 +/- 0.5) and born in 1999, 2000 or 2001. The children also had a physical examination by an allergist and dentists. Dental caries was diagnosed according to WHO criteria. Caries experience was measured as number of deft and defs. Logistic regression analysis assessed the association between dental caries and independent variables. The dental caries prevalence was 17.9%, 28.8% of the children had allergic rhinitis symptoms, digit sucking was reported by 9.8% and pacifier use by 13.6% of the children. The mean number of deft of the sample was 1.02 (SD = 2.37) and that of defs was 1.33 (SD = 3.54). Analysis showed that breast-feeding for >12 months (p < 0.01), toothbrushing frequency (p < 0.01), sugar consumption (p < 0.01) and pacifier use (p < 0.01) each had a significant association with dental caries occurrence in primary dentition. Children with pacifier use and allergic rhinitis had more than double the risk of dental caries development. Allergic rhinitis alone has no effect on dental caries. Healthcare professionals attempting to limit dental caries should consider the effect of prolonged breast-feeding, sugary product consumption between meals and nonnutritive habits on dental caries.

  16. Urban Tree Canopy and Asthma, Wheeze, Rhinitis, and Allergic Sensitization to Tree Pollen in a New York City Birth Cohort

    OpenAIRE

    Lovasi, Gina S.; O’Neil-Dunne, Jarlath P.M.; Lu, Jacqueline W.T.; Sheehan, Daniel; Perzanowski, Matthew S.; MacFaden, Sean W.; King, Kristen L.; Matte, Thomas; Miller, Rachel L.; Hoepner, Lori A.; Perera, Frederica P.; Rundle, Andrew

    2013-01-01

    Background: Urban landscape elements, particularly trees, have the potential to affect airflow, air quality, and production of aeroallergens. Several large-scale urban tree planting projects have sought to promote respiratory health, yet evidence linking tree cover to human health is limited. Objectives: We sought to investigate the association of tree canopy cover with subsequent development of childhood asthma, wheeze, rhinitis, and allergic sensitization. Methods: Birth cohort study data w...

  17. Increased Expression of miR-146a in Children With Allergic Rhinitis After Allergen-Specific Immunotherapy

    OpenAIRE

    LUO, XI; Hong, Haiyu; Tang, Jun; Wu, Xingmei; Lin, Zhibin; Ma, Renqiang; Fan, Yunping; Xu, Geng; Liu, Dabo; Li, Huabin

    2015-01-01

    Purpose MicroRNAs (miRs) were recently recognized to be important for immune cell differentiation and immune regulation. However, whether miRs were involved in allergen-specific immunotherapy (SIT) remains largely unknown. This study sought to examine changes in miR-146a and T regulatory cells in children with persistent allergic rhinitis (AR) after 3 months of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Methods Twenty-four HDM-sensitized children with persistent AR...

  18. Development of a Questionnaire for the Assessment of Quality of Life in Korean Children With Allergic Rhinitis

    OpenAIRE

    Kim, Jeong Hee; Ahn, Young Mee; Kim, Hyung Jin; Lim, Dae Hyun; Son, Byong Kwan; Kang, Hee Suk; Song, Young Eun; Lee, Hee Young

    2014-01-01

    Purpose Korean children have their own unique lifestyle based on their living environment and culture. This study aimed to develop a questionnaire to evaluate the quality of life in Korean children with allergic rhinitis. Methods After a preliminary survey, an initial questionnaire was developed. Questions were modified to be easily understood by young children aged 6 to 7 years. The modified questionnaire was tested on children aged 6 to 12 years old. Item scores, defined as the proportion o...

  19. Clinical Profile, Co-Morbidities and Health Related Quality of Life in Pediatric Patients with Allergic Rhinitis and Asthma

    OpenAIRE

    Keya R. Lahiri, Milind S. Tullu* and Rachna Kalra

    2010-01-01

    Background: Co-existence of allergic rhinitis (AR) and bronchial asthma (BA) is well known. We planned to study the clinical profile of patients with AR & BA, the associated co-morbidities and the effect of AR &/ or BA on health related quality of life (HRQOL) in Pediatric patients. Methods: Patients attending the Pediatric out-patients department and Pediatric Chest Clinic of tertiary care center were enrolled. The sample size included 100 subjects with BA & AR (Group 1) with control groups ...

  20. Control of allergic rhinitis and asthma test – a formal approach to the development of a measuring tool

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    Fonseca Joao A

    2009-06-01

    Full Text Available Abstract Background The concurrent management of allergic rhinitis and asthma (ARA has been recommended by Allergic Rhinitis and its Impact on Asthma (ARIA guidelines. However, a tool capable of assessing simultaneously the control of upper and lower airways diseases is lacking. Aim To describe the studies conducted to design the control of ARA test (CARAT questionnaire. Methods We performed a literature review to generate a list of potentially important items for the assessment of control of ARA. A formal consensus development process, that used an innovative web-based application, was designed – 111 experts in ARA and 60 patients participated. At the final consensus meeting, 25 primary and secondary care physicians formulated the questions and response options. A qualitative feasibility study (n = 31 patients was conducted to evaluate the comprehensibility of the questionnaire while testing two different designs. Results Thirty-four potentially important items were identified. All the steps of the consensus process were completed in 2.5 months. The opinions of experts and patients lead to the formulation of 17 questions. At the feasibility study the instructions and wording problems were corrected and a semi-tabular format was chosen. Conclusion A tool to measure the control of allergic rhinitis and asthma was developed using a comprehensive set of methodological steps ensuring the design quality and the face and content validity. Additional validation studies to assess the psychometric properties of the questionnaire have started.

  1. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis.

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    Jurgita Saulyte

    2014-03-01

    Full Text Available Allergic rhinitis, allergic dermatitis, and food allergy are extremely common diseases, especially among children, and are frequently associated to each other and to asthma. Smoking is a potential risk factor for these conditions, but so far, results from individual studies have been conflicting. The objective of this study was to examine the evidence for an association between active smoking (AS or passive exposure to secondhand smoke and allergic conditions.We retrieved studies published in any language up to June 30th, 2013 by systematically searching Medline, Embase, the five regional bibliographic databases of the World Health Organization, and ISI-Proceedings databases, by manually examining the references of the original articles and reviews retrieved, and by establishing personal contact with clinical researchers. We included cohort, case-control, and cross-sectional studies reporting odds ratio (OR or relative risk (RR estimates and confidence intervals of smoking and allergic conditions, first among the general population and then among children. We retrieved 97 studies on allergic rhinitis, 91 on allergic dermatitis, and eight on food allergy published in 139 different articles. When all studies were analyzed together (showing random effects model results and pooled ORs expressed as RR, allergic rhinitis was not associated with active smoking (pooled RR, 1.02 [95% CI 0.92-1.15], but was associated with passive smoking (pooled RR 1.10 [95% CI 1.06-1.15]. Allergic dermatitis was associated with both active (pooled RR, 1.21 [95% CI 1.14-1.29] and passive smoking (pooled RR, 1.07 [95% CI 1.03-1.12]. In children and adolescent, allergic rhinitis was associated with active (pooled RR, 1.40 (95% CI 1.24-1.59 and passive smoking (pooled RR, 1.09 [95% CI 1.04-1.14]. Allergic dermatitis was associated with active (pooled RR, 1.36 [95% CI 1.17-1.46] and passive smoking (pooled RR, 1.06 [95% CI 1.01-1.11]. Food allergy was associated with SHS (1

  2. The effect of encasings on quality of life in adult house dust mite allergic patients with rhinitis, asthma and/or atopic dermatitis

    NARCIS (Netherlands)

    Terreehorst, [No Value; Duivenvoorden, HJ; Tempels-Pavlica, Z; Oosting, AJ; de Monchy, JGR; Bruijnzeel-Koomen, CAFM; van Wijk, R.

    2005-01-01

    Background: Environmental control has been put forward as an integral part of the management of house dust mite (HDM) allergy in sensitized patients. To validate this statement allergic disorders involved in HDM allergy - allergic asthma, rhinitis and atopic eczema/dermatitis syndrome (AEDS) - shoul

  3. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.

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    Ekaterina Maslova

    Full Text Available BACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. RESULTS: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33 times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66 and medication (1.13, 95% CI: 0.98, 1.29 registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74 during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. CONCLUSION: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially

  4. Number and subtypes of natural killer cells in patients with allergic rhinitis in comparison to healthy subjects

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    Mehrnaz Mesdaghi

    2010-04-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Allergic rhinitis is a common disorder with great morbidity. Its prevalence has increased during recent years, therefore attracting attentions to its mechanisms. Type 2 cytokines play a major role in allergies. It has been proposed that Natural killer (NK cells may be able to produce type 2 cytokines. This study was done to evaluate NK cells number and subtypes in patients with allergic rhinitis, comparing healthy subjects."n"nMethods: In a case control study, patients with allergic rhinitis were compared to healthy non-atopic subjects. Allergic rhinitis was diagnosed according to ARIA guidelines. NK cells quantity was studied by staining of peripheral blood mono nuclear cells with anti-CD16-FITC and anti-CD56-PE and evaluated by two color flowcytometry. Intracellular cytokines were evaluated by tri-color flowcytometry. NK cells were separated by magnetic beads, and cultured for 72 hours. Secretion of IL-4, IL-5, IL-10, IL-13, and IFN-γ was measured by ELISA, in stimulated and unstimulated conditions."n"nResults: Patients had more CD16+ CD56+ NK cells than control group. IL-4+ NK cells were significantly higher in patients (p<0.001, but the number of IFN-γ+ NK cells was not different. Cytokine secretion

  5. Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

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    Said Said A

    2012-11-01

    Full Text Available Abstract Background Allergic rhinitis is one of the commonest atopic diseases which contribute to significant morbidity world wide while its epidemiology in Tanzania remains sparse. There was paucity of information regarding allergic rhinitis in our setting; therefore it was important to conduct this study to describe our experience on allergic rhinitis, associated co-morbidities and treatment outcome in patients attending Bugando Medical Centre. Methods This was descriptive cross-sectional study involving all patients with a clinical diagnosis of allergic rhinitis at Bugando Medical Centre over a three-month period between June 2011 and August 2011. Data was collected using a pre-tested coded questionnaire and analyzed using SPSS statistical computer software version 17.0. Results A total of 190 patients were studied giving the prevalence of allergic rhinitis 14.7%. The median age of the patients was 8.5 years. The male to female ratio was 1:1. Adenoid hypertrophy, tonsillitis, hypertrophy of inferior turbinate, nasal polyps, otitis media and sinusitis were the most common co-morbidities affecting 92.6% of cases and were the major reason for attending hospital services. Sleep disturbance was common in children with adenoids hypertrophy (χ2 = 28.691, P = 0.000. Allergic conjunctivitis was found in 51.9%. The most common identified triggers were dust, strong perfume odors and cold weather (P χ2 = 4.583, P = 0.032. In this study family history of allergic rhinitis was not a significant risk factor (P =0.423. The majority of patients (68.8% were treated surgically for allergic rhinitis co morbidities. Post operative complication and mortality rates were 2.9% and 1.6% respectively. The overall median duration of hospital stay of in-patients was 3 days (2 – 28 days. Most patients (98.4% had satisfactory results at discharge. Conclusion The study shows that allergic rhinitis is common in our settings representing 14.7% of all

  6. Frequency of Allergic Rhinitis in School-age Children (7-18 Years in Tehran

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    Bahram Mirsaid Ghazi

    2003-12-01

    Full Text Available Allergic Rhinitis (AR is one of the most common allergic disorders of child¬hood.In order to determine the frequency of AR among school-age children, a cross-sectional study was performed.One thousand, nine hundred and thirty-two children (931 boys and 1001 girls, aged 7-18 years, from 30 systematic randomly selected schools of Tehran, the capital of Iran, were investigated in this study. Screening was made on the basis of the questionnaire according to International Study of Asthma and Aller¬gies in Childhood protocol. Diagnosis was confirmed by history and physical examination.Four hundred and fifty-five (240 boys and 215 girls out of 1932 screened children had AR (23.5%. Seasonal AR and perennial forms were detected in 329 and 126 cases, respectively. The symptoms of seasonal AR were noted at spring (68.7%, summer (15.8%, and fall and winter (15.5%. The total preva¬lence of asthma was 3.5% according to questionnaire, which was lower than the prevalence (7.2% in the AR subjects. The prevalence of cutaneous allergy also was 35.8% in children with AR. The positive history of atopy (AR, asthma, or cutaneous allergy in the first degree relatives was detected in 47.9% in AR cases. Moreover, the history of contact with animals was positive in 35.4% of cases withAR.AR is common among school-age children in Tehran. Coincidence of AR with asthma or cutaneous allergy is significant. Family history of allergy and his¬tory of contact with animals and cockroaches are important risk factors in the incidence of AR.

  7. Analysis of clinical features in allergic rhinitis and non-allergic rhinitis%非变应性鼻炎与变应性鼻炎患者临床特征分析

    Institute of Scientific and Technical Information of China (English)

    刘天宝

    2014-01-01

    目的:比较非变应性鼻炎与变应性鼻炎的临床特征及并发症。方法278例鼻炎患者分为变应性鼻炎组( AR组)与非变应性鼻炎组( NAR组)。记录2组的临床症状、疾病严重程度与时间、并发症,比较2组的异同。结果 AR组的鼻部症状、眼部症状、咳嗽出现的频率明显高于NAR组,差异有统计学意义( P<0.05)。2组中多为中重度持续性患者,轻度持续性患者的数量最少。 AR组的中重度间歇性患者明显多于NAR组的患者(P<0.05)。2组出现心血管疾病、下呼吸道并发症患者的构成比差异有统计学意义( P<0.05)。 AR组患者的下呼吸道疾病主要为哮喘,人数明显多于NAR组的哮喘患者。2组患者药物过敏史比较差异无统计学意义( P>0.05)。结论变应性与非变应性鼻炎是两类不同疾病,其发病机制、临床特征及并发症均存在一定差异。%Objective To compare the clinical features and complications in allergic rhinitis ( AR) and non-allergic rhinitis ( NAR) .Methods Two hundred and seventy-eight patients with rhinitis were divided into the allergic rhinitis group ( or the AR group) and the non-allergic rhinitis group (or the NAR group).Clinical symptoms, severity/course of the disease and complications were recorded, and then, similarities and differences in the above data were compared between the two groups.Results Nasal symp-toms, ocular symptoms, cough frequency in the patients of the AR group were obviously higher than those of the patients in the NAR group, all with statistical significance (P0.05).However, statistical significance could be noticed in the ratio of patients with cardiovascular disease and lower respiratory tract complications (P>0.05).Conclusion Allergic rhinitis and non-allergic rhinitis are two different diseases, and pathogenesis, clinical features and complications are quite different.At present, there are no clear

  8. Air pollution exposure and daily clinical visits for allergic rhinitis in a subtropical city: Taipei, Taiwan.

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    Chen, Chih-Cheng; Chiu, Hui-Fen; Yang, Chun-Yuh

    2016-01-01

    This study was undertaken to determine whether there was an association between air pollutant level exposure and daily clinic visits for allergic rhinitis (AR) in Taipei, Taiwan. Daily clinic visits for AR and ambient air pollution data for Taipei were obtained for the period of 2006-2011. The relative risk for clinic visits for AR was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant models, on warm days (>23ºC) significant positive associations were found for increased rate of AR occurrence and ambient levels of particulate matter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3). On cool days (air pollutants were significantly associated with elevated number of AR visits except SO2. For the two-pollutant models, PM10, O3, and NO2 were significantly associated with higher rate of AR visits in combination with each of the other four pollutants on cool days. On warm days, CO levels remained significantly related with increased AR visits in all two-pollutant models. This study provides evidence that higher levels of ambient air contaminants enhance the risk of elevated frequency of clinic visits for AR. PMID:27294298

  9. Effects of Low Level Laser Therapy on Ovalbumin-Induced Mouse Model of Allergic Rhinitis

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    Binhye Choi

    2013-01-01

    Full Text Available Introduction. This study was designed to investigate the effects of low level laser therapy (LLLT on experimental allergic rhinitis (AR models induced by ovalbumin. Materials and Methods. AR was induced by 1% ovalbumin in mice. Twenty-four mice were divided into 4 groups: normal, control, low, and high dose irradiation. Low and high dose LLLT were irradiated once a day for 7 days. Total IgE, cytokines concentrations (IL-4 and IFN-γ, and thymus and activation regulated chemokine (TARC were measured. Histological changes in the nasal mucosal tissue by laser irradiation were examined. Results. LLLT significantly inhibited total IgE, IL-4, and TARC expression in ovalbumin-induced mice at low dose irradiation. The protein expression level of IL-4 in spleen was inhibited in low dose irradiation significantly. IL-4 expression in EL-4 cells was inhibited in a dose dependent manner. Histological damages of the epithelium in the nasal septum were improved by laser irradiation with marked improvement at low dose irradiation. Conclusion. These results suggest that LLLT might serve as a new therapeutic tool in the treatment of AR with more effectiveness at low dose irradiation. To determine the optimal dose of laser irradiation and action mechanisms of laser therapy, further studies will be needed.

  10. Sensitization and exposure to pet allergens in asthmatics versus non-asthmatics with allergic rhinitis.

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    Henriksen, A H; Holmen, T L; Bjermer, L

    2001-02-01

    In sensitized subjects with allergic rhinitis (AR) or asthma, allergen exposure provokes symptoms. Among non-asthmatics with AR, an association between allergen sensitization, pollen season and lower airway inflammation has been demonstrated. Our aims were to compare AR and asthma with regard to patterns of allergen sensitization, the degree of airway hyperresponsiveness (AHR) and levels of exhaled nitric oxide (ENO). Finally, we wanted to relate our findings to previous or current exposure to household pets. Four hundred and thirty-one adolescents with different clinical phenotypes were randomly selected from a large-scale epidemiological survey. They were investigated with allergy screening, measurements of ENO and a methacholine bronchoprovocation test. Sensitization to pet allergens (cat, dog and horse) was associated with increased AHR and ENO both in asthmatics and non-asthmatics with AR. The risk of being sensitized to cat allergens was significantly reduced in those who had kept cats vs. those who had never kept them. Keeping dogs or horses did not influence the risk of being sensitized to the respective allergens. Only in steroid-naive, non-smoking asthmatics, a trend towards increased ENO in those sensitized and exposed to cat or dog allergens was seen. Although sensitization towards pet allergens was associated with inflammation in the lower airways irrespective of clinical phenotype, keeping pets did not increase the risk of being sensitized to pet allergens. PMID:11217908

  11. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis.

    Science.gov (United States)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W; Arnavielhe, Sylvie; Bachert, Claus; Bedbrook, Anna; Bergmann, Karl-Christian; Bosnic-Anticevich, Sinthia; Brozek, Jan; Calderon, Moises; Canonica, G Walter; Casale, Thomas B; Chavannes, Niels H; Cox, Linda; Chrystyn, Henry; Cruz, Alvaro A; Dahl, Ronald; De Carlo, Giuseppe; Demoly, Pascal; Devillier, Phillipe; Dray, Gérard; Fletcher, Monica; Fokkens, Wytske J; Fonseca, Joao; Gonzalez-Diaz, Sandra N; Grouse, Lawrence; Keil, Thomas; Kuna, Piotr; Larenas-Linnemann, Désirée; Lodrup Carlsen, Karin C; Meltzer, Eli O; Mullol, Jaoquim; Muraro, Antonella; Naclerio, Robert N; Palkonen, Susanna; Papadopoulos, Nikolaos G; Passalacqua, Giovanni; Price, David; Ryan, Dermot; Samolinski, Boleslaw; Scadding, Glenis K; Sheikh, Aziz; Spertini, François; Valiulis, Arunas; Valovirta, Erkka; Walker, Samantha; Wickman, Magnus; Yorgancioglu, Arzu; Haahtela, Tari; Zuberbier, Torsten

    2016-08-01

    The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials.

  12. Association between the First Occurrence of Allergic Rhinitis in Preschool Children and Air Pollution in Taiwan.

    Science.gov (United States)

    Chung, Hui-Ying; Hsieh, Chia-Jung; Tseng, Chun-Chieh; Yiin, Lih-Ming

    2016-03-01

    The occurrence of allergic rhinitis (AR) may be significantly influenced by air pollution. This study examined the association between the first occurrence of AR in preschool children and the pre-incident levels of air pollutants in Taiwan. We identified 9960 eligible subjects from a systematic sampling cohort database containing 400,000 insureds of the National Health Insurance from 2007 to 2011 and matched them with the environmental monitoring data from 2006 to 2011 according to the locations of their clinics. Pre-incident levels were determined using the average concentrations of air pollutants one or two weeks prior to the AR diagnoses. Logistic regression analyses were performed to determine any significant relationships between AR and specific air pollutants. The first AR incidence for Taiwanese preschool children, which increased with age, was 10.9% on average; boys appeared to have a higher percentage (14.2%) than girls (8.27%). Among the air pollutants, carbon monoxide (CO) and nitrogen oxides (NOX) were significantly related to AR after adjusting for age and gender (p < 0.05). Because both pollutants are considered to be traffic emissions, this study suggests that traffic emissions in Taiwan need to be controlled to lower the prevalence of children's AR. PMID:26927153

  13. Association between the First Occurrence of Allergic Rhinitis in Preschool Children and Air Pollution in Taiwan

    Directory of Open Access Journals (Sweden)

    Hui-Ying Chung

    2016-02-01

    Full Text Available The occurrence of allergic rhinitis (AR may be significantly influenced by air pollution. This study examined the association between the first occurrence of AR in preschool children and the pre-incident levels of air pollutants in Taiwan. We identified 9960 eligible subjects from a systematic sampling cohort database containing 400,000 insureds of the National Health Insurance from 2007 to 2011 and matched them with the environmental monitoring data from 2006 to 2011 according to the locations of their clinics. Pre-incident levels were determined using the average concentrations of air pollutants one or two weeks prior to the AR diagnoses. Logistic regression analyses were performed to determine any significant relationships between AR and specific air pollutants. The first AR incidence for Taiwanese preschool children, which increased with age, was 10.9% on average; boys appeared to have a higher percentage (14.2% than girls (8.27%. Among the air pollutants, carbon monoxide (CO and nitrogen oxides (NOX were significantly related to AR after adjusting for age and gender (p < 0.05. Because both pollutants are considered to be traffic emissions, this study suggests that traffic emissions in Taiwan need to be controlled to lower the prevalence of children’s AR.

  14. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis.

    Science.gov (United States)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W; Arnavielhe, Sylvie; Bachert, Claus; Bedbrook, Anna; Bergmann, Karl-Christian; Bosnic-Anticevich, Sinthia; Brozek, Jan; Calderon, Moises; Canonica, G Walter; Casale, Thomas B; Chavannes, Niels H; Cox, Linda; Chrystyn, Henry; Cruz, Alvaro A; Dahl, Ronald; De Carlo, Giuseppe; Demoly, Pascal; Devillier, Phillipe; Dray, Gérard; Fletcher, Monica; Fokkens, Wytske J; Fonseca, Joao; Gonzalez-Diaz, Sandra N; Grouse, Lawrence; Keil, Thomas; Kuna, Piotr; Larenas-Linnemann, Désirée; Lodrup Carlsen, Karin C; Meltzer, Eli O; Mullol, Jaoquim; Muraro, Antonella; Naclerio, Robert N; Palkonen, Susanna; Papadopoulos, Nikolaos G; Passalacqua, Giovanni; Price, David; Ryan, Dermot; Samolinski, Boleslaw; Scadding, Glenis K; Sheikh, Aziz; Spertini, François; Valiulis, Arunas; Valovirta, Erkka; Walker, Samantha; Wickman, Magnus; Yorgancioglu, Arzu; Haahtela, Tari; Zuberbier, Torsten

    2016-08-01

    The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials. PMID:27260321

  15. Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis

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    Wenlong Liu

    2014-01-01

    Full Text Available Background. Interleukin-37 (IL-37, a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses, especially its isoform IL-37b. Objective. This study was undertaken to evaluate the expression and regulation of IL-37b in children with allergic rhinitis (AR. Methods. Forty children with AR and twenty-five normal controls were included. The relationship between IL-37b and Th1/2 cytokines production in serum and nasal lavage was examined by enzyme-linked immunosorbent assay (ELISA. Peripheral blood mononuclear cells (PBMCs were purified for in vitro regulation experiment of IL-37b. Intranasal mometasone furoate was given in AR children and IL-37b change after one-month treatment was detected using ELISA. Results. We observed significantly decreased IL-37b expression levels in both serum and nasal lavage compared to controls. IL-37b was negatively correlated with Th2 cytokines. Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and this modulation was through mitogen-activated protein kinase (MAPK and phosphatidylinositol 3-kinase (PI3K pathway. We also found that intranasal mometasone furoate therapy can promote nasal IL-37b expression. Conclusion. IL-37b may be involved in Th2 cytokine regulation in AR and its expression was related to the efficacy of intranasal steroid therapy.

  16. [Antigen specific immunoglobulin E to grass and weed pollens in the plasma of patients with seasonal allergic rhinitis].

    Science.gov (United States)

    Silny, W; Kuchta, D; Siatecka, D; Silny, P

    1999-01-01

    The study involved 22 patients with seasonal allergic rhinitis between 13 and 53 years of age. The level of antigen specific IgE (AS IgE) to 5 grass and 3 weed pollens was determined with the use of CAP FEIA (Pharmacia, Uppsala, Sweden). The control group consisted of 20 persons. All above AS IgE were significantly higher in the patients with seasonal allergic rhinithis than in the control group. The most commonly present hypersensitivities were to Meadow fescue (Festuca elatior), Meadow grass (Poa pratensis), Cocksfoot (Dactylis glomerata), Ribwort (Plantago lanceolata) and Mugwort (Artemisia vulgaris) allergens. The authors believe that the pathomechanism of the development of seasonal allergic rhinithis is governed to a large degree by hypersensitivity to grass and weed pollens and suggest that precise determination of AS IgE to these allergens in patients blood sera should form the basis of the construction of the vaccine used in their immunotherapy. PMID:10337158

  17. Experimental animal models of allergic rhinitis and evaluation%变应性鼻炎动物模型的研究进展

    Institute of Scientific and Technical Information of China (English)

    赖其廷; 曾军

    2009-01-01

    Allergic rhinitis is an allergic disease, which is a local reaction of the whole body, It has high incidence and complex pathogenesis. The establishment of animal modesl which is well simulated to the human's allergic rhinitis is helpful for us to study the pathogenesis and the treatment of allergic rhinitis more clearly. Many animal models of allergic rinitis have been found until now. This article reviewes the different animal models with allergic rhinitis.%变应性鼻炎是一种变态反应性疾病,是全身变应性炎症的局部反应,发病率高,发病机制复杂,因此,建立能够较好的模拟人类变应性鼻炎的动物模型有助于对其发病机制和治疗进行深入研究.目前,已经建立了多种变应性鼻炎的动物模型.本文就用各种动物建立的变应性鼻炎模型作如下综述.

  18. Antileucotrienos no tratamento da asma e rinite alérgica Antileukotrienes in the treatment of asthma and allergic rhinitis

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    Jose Dirceu Ribeiro

    2006-11-01

    Full Text Available OBJETIVO: Comparar os antagonistas de leucotrienos (ARLT aos outros grupos de medicamentos utilizados para tratar a asma e a rinite alérgica. FONTES DOS DADOS: MEDLINE, LILACS e Biblioteca Cochrane. Palavras chaves: leucotrienos, antileucotrienos, tratamento da asma, tratamento da rinite alérgica, asma e rinite alérgica. Procurou-se agrupar os principais trabalhos e revisões sobre o assunto. SÍNTESE DOS DADOS: Os ARLT são mais eficazes do que placebo e potencializam os efeitos dos corticosteróides inalados. A associação de corticosteróides inalados com agentes beta2 agonistas de longa duração (LABA é mais eficaz do que a associação de cortiscoteróides inalados + ARLT. Embora pareça racional o uso de ARLT na crise aguda de asma e rinite alérgica, mais estudos são necessários para comprovar esse benefício. Os ARLT promovem redução no tempo de hospitalização e no número de crises de sibilância em lactentes com bronquiolite viral aguda pelo vírus respiratório sincicial e na sibilância recorrente após bronquiolite viral aguda. Os ARLT são menos eficazes que os corticosteróides intranasais no manejo da rinite alérgica. Os ARLT são eficazes na asma induzida por exercício (AIE, embora não constituam a primeira linha de tratamento. CONCLUSÃO: Estudos controlados e randomizados mostram que os corticosteróides inalados são as drogas de escolha para o tratamento da asma persistente e rinite alérgica. :Não existem evidências suficientes para recomendar o uso de ARLT como medicamento de primeira linha (monoterapia em crianças com asma (nível I. Nas crianças que não podem usar corticosteróides inalados, os ARLT podem ser uma alternativa (nível II.OBJECTIVE: To compare leukotriene antagonists (LTA to other groups of drugs used in asthma and allergic rhinitis treatment. SOURCES: MEDLINE, LILACS and Cochrane Library. Keywords: leukotrienes, antileukotrienes, asthma treatment, allergic rhinitis treatment, asthma and

  19. Comparative Study of Apo-Cetirizine Single Therapy and Intermittent Sequential Therapy with Cetirizine, Loratadine and Chlorpheniramine in Allergic Rhinitis.

    Science.gov (United States)

    Safavi Naini, Ali; Ghorbani, Jahangir; Mazloom, Ebrahim

    2016-09-01

    There are limited numbers of articles, studying combined use of antihistamines. In this study, we compare single therapy of Apo-Cetirizine with a new regimen of intermittent sequential therapy with cetirizine, loratadine and chlorpheniramine in treatment of seasonal allergic rhinitis. This randomized clinical trial was performed between April and September at the peak prevalence of seasonal allergic rhinitis. Fifty-four eligible patients diagnosed clinically to have seasonal allergic rhinitis were randomized in two groups: 24 cases in single therapy arm, received Apo-Cetirizine 10 mg tablet daily and in other arm, 30 patients received sequential regimen of cetirizine 10 mg tablet, loratadine 10 mg tablet and chlorpheniramine 4 mg tablet, one tablet each day. Major Symptom Complex Score (MSCS) and Total Symptom Complex Score (TSCS) of patients were recorded before treatment and after 30 days of treatment in two groups. The average post-treatment MSCS and TSCS in combination therapy group showed better improvement than single therapy group but difference was not statistically significant (p value = 0.053 and p value = 0.104 respectively). Combination therapy regimen was better in improvement of nasal congestion (p value = 0.006). There were no significant difference between two groups in efficacy, side effects and patient's satisfaction. Combination therapy would be effective on a wide spectrum of symptoms with lower price and theoretically offers lower chance of tolerance and re-appearance of complaints. PMID:27508135

  20. H1 antihistamines in allergic rhinitis: The molecular pathways of interleukin and toll - like receptor systems

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    Jonny Karunia Fajar

    2016-03-01

    Full Text Available The complex interaction between inflammatory mediators in allergic rhinitis (AR is determined by the role of genetic polymorphisms, including interleukin (IL and toll-like receptor (TLR genes. This study aimed to discuss the effects of H1-antihistamines on IL and TLR systems. Several ILs involved in AR pathogenesis are: IL-4 (rs2243250, rs1800925, rs1801275, rs2227284, rs2070874, IL-6 (rs1800795, rs1800797, IL-10 (rs1800871, rs1800872, IL-12R (rs438421, IL-13 (rs1800925, rs20541, IL-17 (rs3819024, IL-18 (rs360721, rs360718, rs360717, rs187238, IL-23R (rs7517847, and IL-27 (rs153109, rs17855750. In the IL system, histamines stimulate the IL production in Type 2 helper T (Th2 cells through protein kinase A (PKA, janus kinase-signal transducer and activator of transcription (JAK-STAT pathway, and the activation of H1-histamine receptor and histidine decarboxylase (HDC genes. On contrary, antihistamines down-regulate the H1-histamine receptor gene expression through the transcription suppression of HDC and IL genes and suppress histamine basal signaling through the inverse agonistic activity. TLRs involved in AR pathogenesis are TLR2 (rs4696480, rs3804099, rs5743708, TLR4 (rs4986790, TLR6 (rs2381289, TLR7 (rs179008, rs5935438, TRL8 (rs2407992, rs5741883, rs17256081, rs4830805, rs3788935, rs178998, and TLR10 (rs11466651. In the TLR system, histamines trigger the TLR expression by stimulating interferon-γ (IFN-γ to up-regulate mast cells and by stimulating receptor-interacting protein (RIP to activate IκB kinase-β. Contrastingly, antihistamines suppress TIR-domain-containing adaptor protein inducing IFN-β (TRIF and RIP protein and thus inhibit the expression of TLR. In addition, several studies indicated that H1-antihistamines inhibit the IL and TLR systems indirectly.

  1. Identification of novel biomarkers in seasonal allergic rhinitis by combining proteomic, multivariate and pathway analysis.

    Directory of Open Access Journals (Sweden)

    Hui Wang

    Full Text Available BACKGROUND: Glucocorticoids (GCs play a key role in the treatment of seasonal allergic rhinitis (SAR. However, some patients show a low response to GC treatment. We hypothesized that proteins that correlated to discrimination between symptomatic high and low responders (HR and LR to GC treatment might be regulated by GCs and therefore suitable as biomarkers for GC treatment. METHODOLOGY/PRINCIPAL FINDINGS: We identified 953 nasal fluid proteins in symptomatic HR and LR with a LC MS/MS based-quantitative proteomics analysis and performed multivariate analysis to identify a combination of proteins that best separated symptomatic HR and LR. Pathway analysis showed that those proteins were most enriched in the acute phase response pathway. We prioritized candidate biomarkers for GC treatment based on the multivariate and pathway analysis. Next, we tested if those candidate biomarkers differed before and after GC treatment in nasal fluids from 40 patients with SAR using ELISA. Several proteins including ORM (P<0.0001, APOH (P<0.0001, FGA (P<0.01, CTSD (P<0.05 and SERPINB3 (P<0.05 differed significantly before and after GC treatment. Particularly, ORM (P<0.01, FGA (P<0.05 and APOH (P<0.01 that belonged to the acute phase response pathway decreased significantly in HR but not LR before and after GC treatment. CONCLUSIONS/SIGNIFICANCE: We identified several novel biomarkers for GC treatment response in SAR with combined proteomics, multivariate and pathway analysis. The analytical principles may be generally applicable to identify biomarkers in clinical studies of complex diseases.

  2. Prevalence and socioeconomic associations of asthma and allergic rhinitis in northern [corrected] Africa.

    Science.gov (United States)

    Georgy, V; Fahim, H I; El-Gaafary, M; Walters, S

    2006-10-01

    The aims of the current study were to ascertain the prevalence of asthma and allergic rhinoconjunctivitis symptoms in Cairo, Egypt (northern Africa), and to elucidate the socioeconomic factors associated with symptom prevalence and severity. A translated and adapted version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was distributed to a sample of 2,645 11-15-yr-olds in state and fee-paying schools in Cairo. The overall prevalences of wheeze ever, wheeze during the last year and physician-diagnosed asthma were 26.5% (697 out of 2,631), 14.7% (379 out of 2,570) and 9.4% (246 out of 2,609), respectively. The prevalence of rhinoconjunctivitis was 15.3% (399 out of 2,616). Asthma symptoms were independently associated with attendance at a state school, parental asthma, age, history of rhinitis and owning a pet cat. Rhinoconjunctivitis was independently associated with attendance at a state school, father's education, parental history of asthma, asthma symptoms and owning a pet cat. In spite of a higher prevalence of severe asthma symptoms in state schools prevalence of physician diagnosis of asthma was the same in both school types, suggesting inequalities in access to healthcare. In conclusion, the prevalence of physician-diagnosed asthma in Cairo was 9.4%, while the prevalence of rhinoconjunctivitis was 15.3%. There is a higher prevalence and increased severity of asthma symptoms in children of lower socioeconomic groups, as defined by state school attendance in Cairo.

  3. Intranasal steroids: managing allergic rhinitis and tailoring treatment to patient preference.

    Science.gov (United States)

    Meltzer, Eli O

    2005-01-01

    Allergic rhinitis (AR) can have a significant impact on patient quality of life (QoL), affecting learning ability and work productivity. Both the consequences of the impairment and the costs of treatment are associated with a large economic burden. The management of AR includes allergen avoidance, pharmacotherapy, and immunotherapy. Current pharmacotherapy options are oral and intranasal antihistamines, intranasal corticosteroids (INS), intranasal chromones, oral and intranasal decongestants, oral and intranasal anticholinergic agents, and antileukotrienes. A number of guidelines recommend INS as first-line treatment for persistent and moderate-to-severe AR. Although both patient and physician concern over the long-term safety of oral systemic steroids has previously prevented widespread use of INS, it is important to note that they have a superior risk/benefit ratio compared with other monotherapies. Indeed, the limited systemic bioavailability of INS agents, when used at recommended doses, has resulted in very low rates of systemic adverse effects, as shown by a lack of either hypothalamic-pituitary-adrenal axis or growth suppression. Large, controlled clinical studies have shown comparable efficacy and safety among the newer INS; therefore, clinicians may need to consider other factors, such as good patient compliance, when selecting an appropriate INS agent for a patient. In addition, patients often prefer one agent over another, and compliance may be improved by selecting the preferred agent. The development of two new questionnaires, the Clinical Practice Patient Preference Questionnaire and the Clinical Trial Patient Preference Questionnaire, may prove useful in selecting the optimal treatment regimen for patients. PMID:16541967

  4. A survey of the burden of allergic rhinitis in Hungary from a specialist’s perspective

    Directory of Open Access Journals (Sweden)

    Szilasi Mária

    2012-11-01

    Full Text Available Abstract Background The casual and severity distribution of allergic rhinitis (AR in Hungary is unknown. The aim of this survey was to evaluate symptom perception, disease severity, concomitant asthma frequency and the impact of AR on everyday life activities in a cross-sectional, multicenter study in Hungary under the supervision of Hungarian Respiratory Society. Methods Data were recorded by 933 AR patients (65.93% women and their treating specialists. The perceptions of patients regarding the symptoms (nasal, ocular and others of AR and its severity, together with its impact on everyday life were assessed. Physicians recorded data regarding the diagnosis and severity of AR, and comorbidities. Results 52.5% of patients suffered from seasonal AR, 35.1% from perennial AR. A large proportion of patients had moderate to severe disease (MS-AR (57.34%, persistent disease (98.0% and concomitant asthma (53.32% in the mild, 57.52% in the MS-AR group. MS-AR was more frequent among women. Despite the treatment used, in MS-AR the proportions of patients reporting moderate to severe rhinorrhoea, nasal obstruction, ocular itching/redness, watering, itchy throat and sneezing were as high as 52.0%, 54.0%, 33.8%, 26.5%, 44.0% and 31.2%, respectively. Overall, there was a poor agreement between disease severity reported by patients and specialists. The adherence to oral antihistamines and intranasal corticosteroids was found to be between 50 and 65%; mostly depending on the dosage form. Conclusions AR remains a significant health problem in Hungary because of the burden of symptoms, high rate of concomitant asthma and the significant proportion of MS-AR affecting general well being.

  5. Adverse Events during Immunotherapy against Grass Pollen-Induced Allergic Rhinitis - Differences between Subcutaneous and Sublingual Treatment

    DEFF Research Database (Denmark)

    Aasbjerg, Kristian; Dalhoff, Kim Peder; Backer, Vibeke

    2015-01-01

    Allergic rhinitis (AR) triggered by grass pollen is a common disease, affecting millions of people worldwide. Treatment consists of symptom-alleviating drugs, such as topical corticosteroids or antihistamines. Another option is potentially curative immunotherapy, currently available as sublingual...... and subcutaneous treatment. We investigated the potential differences in the prevalence and severity of adverse events related to subcutaneous and sublingual immunotherapy (SLIT) against grass pollen-induced AR. A thorough literature search was performed with PubMed and EMBASE. The findings were compared...

  6. Seasonal variations of nasal resistance in allergic rhinitis and environmental pollen counts. II: Efficacy of preseasonal therapy.

    Science.gov (United States)

    Naito, K; Ishihara, M; Senoh, Y; Takeda, N; Yokoyama, N; Iwata, S

    1993-01-01

    We gave Mao-bushi-saishin-to, a Chinese blended medicine, and azelastine to an adult patient with hay fever due to Japanese cedar pollen and measured nasal resistance and ambient floating pollen counts throughout the time of Japanese cedar pollination in separated years. In the patient Mao-bushi-saishin-to was effective against preseasonal increases in nasal airway resistance but could not control severe episodes of allergic rhinitis caused by high dose exposure to Japanese cedar pollen and also perhaps caused by a priming effect. Azelastine inhibited both pre- and post-seasonal increases in nasal airway resistance but not only on high pollen counts days.

  7. Imbalance of Peripheral Th17 and Regulatory T Cells in Children with Allergic Rhinitis and Bronchial Asthma

    OpenAIRE

    Baohong Tao; Guiying Ruan; Dongguo Wang; Yong Li; Zhuping Wang; Genquan Yin

    2015-01-01

    The purpose of the present study is to investigate the prevalence of Th17 and regulatory T (Treg) cells in children with allergic rhinitis (AR) accompanying with bronchial asthma (BA).24 children with AR, 22 children with BA, 18 children with AR accompanying with BA,and 20 healthy controls were recruited. The prevalence of peripheral blood Th17 and Treg cells were determined by flow cytometry. mRNA expression of retinoid-acid receptor-related orphan  receptor  (ROR)-γt  and  forkhead  box  P3...

  8. Clinical Research into Ke Min Yin for Treatment of Persistent Allergic Rhinitis in Patients with Qi Deficiency and Blood Stasis

    Institute of Scientific and Technical Information of China (English)

    刘巧平; 刘建华; 刘大新

    2003-01-01

    @@ Persistent allergic rhinitis (PAR) is one of the common diseases at ear-nose-throat department. From August 1998 to May 2001, we randomly selected 60 cases of PAR with qi deficiency and blood stasis for a clinical observation. 30 patients in the treatment group were treated with Ke Min Yin (克敏饮), a herbal medicine, to supplement qi, expel wind, nourish blood and promote blood circulation; and the other 30 cases in the control group were treated with cetrine. Through systematic observation and statistical processing, the clinical research is summarized and reported in the following.

  9. Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

    Institute of Scientific and Technical Information of China (English)

    Cheng ZHOU; Xiao-dong KANG; Zhi CHEN

    2008-01-01

    It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Thl/Tn2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoides farinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that' IFN-γ released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.

  10. 变应性鼻炎相关危险因素的Logistic回归分析%Logistic regression analysis of related risk factors in allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    冯婷; 黄世铮; 鲁航

    2015-01-01

    目的:探讨变应性鼻炎致病的相关因素。方法通过系统抽样方法选取200例变应性鼻炎患者与200例健康体检者,详细记录每例试验者的体育锻炼、饮食习惯、有变应性鼻炎家族史、吸烟史、工作环境粉尘情况、营养状态、晾晒被褥、花粉过敏、每日睡眠、尘螨过敏、养宠物史、食物过敏、开窗通风等情况,采用Logistic回归分析变应性鼻炎致病的相关因素。结果体育锻炼、营养状况、每日睡眠、饮食习惯与变应性鼻炎无相关性,晾晒被褥、开窗通风及空调开放为变应性鼻炎的保护因素,有变应性鼻炎家族史、吸烟史、花粉过敏、尘螨过敏、养宠物史、食物过敏为变应性鼻炎的危险因素。结论有变应性鼻炎家族史、吸烟史、花粉过敏、尘螨过敏、养宠物史、食物过敏是变应性鼻炎的危险因素。%Objective To investigate the factors related to allergic rhinitis disease. Method Chose 200 cases of allergic rhinitis and 200 cases of healthy people through systematic sampling method, detail recorded each case with the physical exercise, diet habit, family history, smoking history, work environment of dust, status, airing quilts, pollen allergy, daily sleep, dust mite allergy history, pet history, food allergies, ventilation windows, used Logistic regression analysis of factors related to allergic rhinitis. Result Physical exercise, nutrition, sleep, diet were not associated with allergic rhinitis, airing quilts, window ventilation and air conditioning open indicated that were protective factors, the rest of family history, smoking history of allergic rhinitis, allergic to pollen, dust mites allergic, pet history and food allergies were risk factors for allergic rhinitis. Conclusion Family history, smoking history, pollen allergy, dust mite allergy, pet history, food allergies are the risk factors of allergic rhinitis.

  11. CLINICAL INVESTIGATIONS ON THE AYURVEDIC MANAGEMENT OF ALLERGIC RHINITIS (VATAJA PRATISHYAYA BY PRATIMARSHA NASYAAS NASAL DRUG DELIVERY SYSTEM.

    Directory of Open Access Journals (Sweden)

    Shiva Kumar

    2014-12-01

    Full Text Available Allergic Rhinitis (AR is an immunoglobulin (Ig E mediated inflammatory disease caused by the inflammation of airway mucosa with hypersensitivity resulting from seasonal or perennial responses to specific allergens. Prevalence of AR is increasing and has risen considerably in the past few decades with self reported prevalence up to 41%. According to Ayurvedic texts indication of Anutaila (classical Ayurvedic oil preparation used in the form of Pratimarsha Nasya a traditional nasal drug delivery system has been used for a long period has shown beneficial effects on diseases of head and neck. A pretest and post test design of single group consisting of 37 patientsdiagnosed as allergic rhinitis were administered Pratimarsha Nasya (PNwith Anutaila daily for a period of 60 days. Effect ofPratimarsha Nasya with Anutaila on the chief complaints and totals nasal symptom score showed ameliorative improvement with statistical significance. Laboratory immunological parameters which included Total Leucocyte Count, Absolute Eosinophil Count, Neutrophils and Lymphocytes showed improvement with high statistical significance (< 0.001. At the end after 60 days of medication the patients showed marked relief in symptoms which can open a new direction in Ayurveda inspired novel targeted drug delivery systems.

  12. Isolation of Aspergillus species from Nasal Cavity and Bedroom of Healthy Volunteers and Patients with Allergic Rhinitis in Mashhad, Iran

    Directory of Open Access Journals (Sweden)

    Samaneh Eidi

    2014-12-01

    Full Text Available Background: The purpose of this study was to investigate the presence, frequency and comparison of Aspergillus spp. in nasal cavity and bedroom of healthy volunteers and patients with allergic rhinitis. Materials and Methods: In this cross-sectional study, a group of patients with allergic rhinitis (N=50 were selected based on positive skin prick test. Healthy volunteers were chosen to be in the comparison group by matching in age, gender, and no history of respiratory system disease. Samples from nasal cavity and different parts of bedroom were collected and cultured. Cultured Aspergillus spp. was identified by standard mycological techniques. Results: The most common species isolated from all samples of healthy volunteers was A. flavus (88%, followed by A. niger (76% and A. fumigatus (74%. A. flavus (56% was the predominant species isolated from all samples of patients, followed by A. niger (34% and A. fumigatus (6%. Conclusion: A. flavus was the most prevalent species of Aspergillus both healthy volunteers and patients. The presence of Aspergillus in homes does not necessarily imply a cause and effect relationship with illness, but we speculate that A. flavus may be a major source of aeroallergens along with A. niger and A. fumigatus; and should alert physicians and healthcare professionals to do more vigorous environmental testing.

  13. Thymic stromal lymphopoietin polymorphisms and allergic rhinitis risk: a systematic review and meta-analysis with 6351 cases and 11472 controls

    OpenAIRE

    Sun, Qiuzhen; Liu, Yuehui; Zhang, Shaorong; Liu, Ke; Zhu, Xinhua; Liu, Jianguo; Yang, Chunping

    2015-01-01

    Previous studies suggested a close association between the thymic stromal lymphopoietin (TSLP) genetic variants and allergic diseases. Here, we explored the correlation between the TSLP polymorphisms and allergic rhinitis susceptibility using meta-analysis. We searched PubMed, Ovid, Cochrane libraries, CNKI, Wanfang, and CQVIP databases until Apr 19, 2015. Quality assessment was conducted for each article according to the Strengthening the Reporting of Genetic Association studies (STREGA). Th...

  14. Hypertonic saline is more effective than normal saline in seasonal allergic rhinitis in children.

    Science.gov (United States)

    Marchisio, P; Varricchio, A; Baggi, E; Bianchini, S; Capasso, M E; Torretta, S; Capaccio, P; Gasparini, C; Patria, F; Esposito, S; Principi, N

    2012-01-01

    Allergic rhinitis (AR) is a very common childhood disease that is associated with a significant reduction in the patients' quality of life. Its treatment combines educating the patients and their parents, immunotherapy and drug administration. However, even the best approach does not relieve the symptoms of a number of patients. Alternative therapies are particularly needed for children because the fear of adverse events frequently reduces parental compliance to the prescribed drugs, and immunotherapy is less easy to administer than in adults. In this prospective investigator-blinded study we evaluated whether children, with a documented history of seasonal grass pollen-related AR, benefit from nasal irrigation by assessing the effects on nasal signs and symptoms, on middle ear effusion and on adenoidal hypertrophy. We randomized children aged 5 to 9 years (median age 82 months) to normal saline or hypertonic saline (a 2.7% sodium chloride solution), administered twice-daily using a disposable 20 ml syringe, or no treatment. Nasal symptoms (rhinorrhea, itching, sneezing, nasal obstruction), swelling of turbinates, adenoid hypertrophy or middle ear effusion were assessed at baseline and after 4 weeks of treatment. Two hundred and twenty children (normal saline: 80; hypertonic saline: 80; no treatment: 60) completed the study. After four weeks, all the considered items were significantly reduced in the group receiving hypertonic saline (P < 0.0001), whereas in the group receiving normal saline only rhinorrhea (P = 0.0002) and sneezing (P = 0.002) were significantly reduced. There was no significant change in any of the items in the control group. The duration of oral antihistamines was significantly lower in the children receiving hypertonic saline than in those treated with normal saline or in controls. No adverse events were reported and parental satisfaction and compliance with the procedure were globally very good, regardless of the solution used. Using our

  15. Patients with Asthma and Comorbid Allergic Rhinitis: Is Optimal Quality of Life Achievable in Real Life?

    OpenAIRE

    Fulvio Braido; Ilaria Baiardini; Stefania Menoni; Federica Gani; Gian Enrico Senna; Erminia Ridolo; Veruska Schoepf; Anthi Rogkakou; Giorgio Walter Canonica

    2012-01-01

    OBJECTIVES: Asthma trials suggest that patients reaching total disease control have an optimal Health Related Quality of Life (HRQoL). Moreover, rhinitis is present in almost 80% of asthmatics and impacts asthma control and patient HRQoL. We explored whether optimal HRQoL was reachable in a real-life setting, and evaluated the disease and patient related patterns associated to optimal HRQoL achievement. METHODS AND FINDINGS: Asthma and rhinitis HRQoL, illness perception, mood profiles, rhinit...

  16. Capsaicin for Rhinitis.

    Science.gov (United States)

    Fokkens, Wytske; Hellings, Peter; Segboer, Christine

    2016-08-01

    Rhinitis is a multifactorial disease characterized by symptoms of sneezing, rhinorrhea, postnasal drip, and nasal congestion. Non-allergic rhinitis is characterized by rhinitis symptoms without systemic sensitization of infectious etiology. Based on endotypes, we can categorize non-allergic rhinitis into an inflammatory endotype with usually eosinophilic inflammation encompassing at least NARES and LAR and part of the drug induced rhinitis (e.g., aspirin intolerance) and a neurogenic endotype encompassing idiopathic rhinitis, gustatory rhinitis, and rhinitis of the elderly. Patients with idiopathic rhinitis have a higher baseline TRPV1 expression in the nasal mucosa than healthy controls. Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the active component of chili peppers, plants of the genus Capsicum. Capsaicin is unique among naturally occurring irritant compounds because the initial neuronal excitation evoked by it is followed by a long-lasting refractory period, during which the previously excited neurons are no longer responsive to a broad range of stimuli. Patients with idiopathic rhinitis benefit from intranasal treatment with capsaicin. Expression of TRPV1 is reduced in patients with idiopathic rhinitis after capsaicin treatment. Recently, in a Cochrane review, the effectiveness of capsaicin in the management of idiopathic rhinitis was evaluated and the authors concluded that given that many other options do not work well in non-allergic rhinitis, capsaicin is a reasonable option to try under physician supervision. Capsaicin has not been shown to be effective in allergic rhinitis nor in other forms of non-allergic rhinitis like the inflammatory endotypes or other neurogenic endotypes like rhinitis of the elderly or smoking induced rhinitis. PMID:27485456

  17. Establishment of animal models of allergic rhinitis: An update%过敏性鼻炎动物模型研究进展

    Institute of Scientific and Technical Information of China (English)

    胡艳菲

    2012-01-01

    过敏性鼻炎(allergic rhinitis,AR)发病呈上升趋势,具有反复发作、迁延难愈的特点,严重影响患者的生活质量,增加社会经济负担.AR动物模型的建立是实验研究的前提.近十年来,该模型建立方法日趋成熟,对于相关评价指标的认识也逐渐深入.文中就该模型研究进展作一综述.%Allergic rhinitis has an increasing incidence in the recent years. With its characteristics of recurrence, persistence and refractoriness, it greatly affects the patients quality of life. Establishment of animal models, as a requisite for basic experimental studies of allergic rhinitis, is becoming more and more mature in methodology and evaluation. This article updates the establishment of animal models of allergic rhinitis.

  18. Role of sphingosine 1-phosphate receptor expression in eosinophils of patients with allergic rhinitis, and effect of topical nasal steroid treatment on this receptor expression.

    LENUS (Irish Health Repository)

    Mackle, T

    2008-12-01

    Recent research has indicated that sphingosine 1-phosphate plays a role in allergy. This study examined the effect of allergen challenge on the expression of sphingosine 1-phosphate receptors on the eosinophils of allergic rhinitis patients, and the effect of steroid treatment on this expression.

  19. Effects of antiallergic herbal agents on cystic fibrosis transmembrane conductance regulator in nasal mucosal epithelia of allergic rhinitis rabbits

    Institute of Scientific and Technical Information of China (English)

    LI Qiang; LI Xiao-li; YANG Xue; BAO Jian-min; SHEN Xiao-hong

    2009-01-01

    Background It has been found that the expression of cystic fibrosis transmembrane conductance regulator (CFTR) is closely related to allergic rhinitis (AR). In the previous study, we have demonstrated that antiallergic herbal agents (AHA) can obviously inhibit the allergic reaction of AR. The aim of this study was to explore the expression of CFTR and the effects of AHA on CFTR to improve the allergic reaction of AR.Methods An animal model of an AR rabbit was established using ovalbumin (OVA). The rhinitis rabbits were randomly assigned to three groups: AHA treating group (AHATG), modeling group (MG) and healthy controlling group (HCG). The expressions of CFTR protein were examined by immunohistochemical method. The mucosal epithelial cells of all the rabbits were primarily cultured with tissue culture method in vitro and treated with or without glibenclamide for 24 hours. The levels of monocyte chemotactic factor-1 (MCP-1) and RANTES protein in supernatants of culture were measured by ELISA, and the expressions of CFTR mRNA were detected by real-time PCR.Results The expressions of CFTR mRNA and protein greatly increased in mucosal epithelial cells of MG. The protein concentrations of MCP-1, RANTES in culture supernatants of MG were significantly higher than those in the other two groups (P0.05).Conclusions AHA can inhibit the secretions of CFTR, RANTES and MCP-1 in mucosal epithelia and improve inflammatory reaction of AR. CFTR may play an important role in the secretion of RANTES and mucosal inflammatory response in AR. Glibenclamide can inhibit the CFTR secretion in mucosal epithelial cells, in particular during AR process. These effects of glibenclamide on secretion of RANTES can be effectively strengthened by AHA.

  20. Factors confusing the diagnosis of laryngopharyngeal reflux: the role of allergic rhinitis and inter-rater variability of laryngeal findings.

    Science.gov (United States)

    Eren, Erdem; Arslanoğlu, Seçil; Aktaş, Ayşe; Kopar, Aylin; Ciğer, Ejder; Önal, Kazım; Katılmiş, Hüseyin

    2014-04-01

    The objective of the study was to determine the inter-rater variability in assessment of laryngeal findings and whether diagnosing laryngopharyngeal reflux based on the laryngeal findings and history alone without considering allergic rhinitis leads to the overdiagnosis and overtreatment of laryngopharyngeal reflux. Patients with positive and negative skin prick tests were recruited from an allergy clinic in a tertiary teaching university hospital. All subjects completed the Reflux Symptom Index (RSI) and underwent laryngeal examinations by three physicians blinded to the skin prick test results and the Reflux Finding Score (RFS) was determined. RFS >7 or RSI >13 was considered reflux positive. Fleiss' kappa (κ) was used to measure inter-rater agreement. The inter-rater agreement was low for pseudosulcus vocalis (κ = 0.078), ventricular obliteration (κ = 0.206), diffuse laryngeal edema (κ = 0.204), and posterior laryngeal hypertrophy (κ = 0.27), intermediate for laryngeal erythema/hyperemia (κ = 0.42) and vocal fold edema (κ = 0.42), and high for thick endolaryngeal mucus (κ = 0.61). Although the frequency of allergy was high, there was no significant difference between allergy-positive and laryngopharyngeal reflux-positive patients. On logistic regression analysis, thick endolaryngeal mucus was a significant predictor of allergy (p = 0.012, odds ratio 0.264, 95 % confidence interval 0.093-0.74). The laryngeal examination for reflux is subject to marked inter-rater variability and allergic laryngitis was not misdiagnosed as laryngopharyngeal reflux. The presence of thick endolaryngeal mucus should alert physicians to the possibility of allergic rhinitis/laryngitis.

  1. Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.

    Science.gov (United States)

    Kawamoto, Yoshiyuki; Ueno, Yuki; Nakahashi, Emiko; Obayashi, Momoko; Sugihara, Kento; Qiao, Shanlou; Iida, Machiko; Kumasaka, Mayuko Y; Yajima, Ichiro; Goto, Yuji; Ohgami, Nobutaka; Kato, Masashi; Takeda, Kozue

    2016-01-01

    The incidence of allergies has recently been increasing worldwide. Immunoglobulin E (IgE)-mediated hypersensitivity is central to the pathogenesis of asthma, hay fever and other allergic diseases. Ginger (Zingiber officinale Roscoe) and its extracts have been valued for their medical properties including antinausea, antiinflammation, antipyresis and analgesia properties. In this study, we investigated the antiallergic effects of ginger and 6-gingerol, a major compound of ginger, using a mouse allergy model and primary/cell line culture system. In mice with ovalbumin (OVA)-induced allergic rhinitis, oral administration of 2% ginger diet reduced the severity of sneezing and nasal rubbing by nasal sensitization of OVA and suppressed infiltration of mast cells in nasal mucosa and secretion of OVA-specific IgE in serum. 6-Gingerol inhibited the expression of not only Th2 cytokines but also Th1 cytokines in OVA-sensitized spleen cells. Accordingly, 6-gingerol suppressed in vitro differentiation of both Th1 cells and Th2 cells from naïve T cells. In addition, 6-gingerol suppressed both superantigen staphylococcal enterotoxin B (SEB)- and anti-CD3-induced T cell proliferation. 6-Gingerol also abrogated PMA plus ionomycin- and SEB-induced IL-2 production in T cells, suggesting that 6-gingerol affected T cell receptor-mediated signal transduction rather than the antigen-presentation process. Indeed, 6-gingerol inhibited the phosphorylation of MAP kinases, calcium release and nuclear localization of c-fos and NF-κB by PMA and ionomycin stimulation. Thus, our results demonstrate that 6-gingerol suppresses cytokine production for T cell activation and proliferation, thereby not causing B cell and mast cell activation and resulting in prevention or alleviation of allergic rhinitis symptoms. PMID:26403321

  2. Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population.

    Directory of Open Access Journals (Sweden)

    Hui-Qin Tian

    Full Text Available As recent studies have described an association between vitamin D and allergic rhinitis, we hypothesized that vitamin D pathway-related genes may be candidate genes for susceptibility to allergic rhinitis. Thus, we sought to evaluate whether polymorphisms in the vitamin D receptor (VDR and CYP2R1 genes are associated with mite-sensitized persistent allergic rhinitis (PER in a Han Chinese population. A hospital-based case-control study consisting of 519 patients with mite-sensitized PER and 447 healthy controls was conducted. Five single nucleotide polymorphisms (SNPs in VDR and CYP2R1 were selected for genotyping. The genotype and allele frequencies of rs9729, rs2228570, rs1544410, and rs731236 in VDR as well as rs2060793 in CYP2R1 were not significantly associated with susceptibility to mite-sensitized PER. After stratification analyses, however, both the CT and CT/TT genotypes of rs2228570 in VDR exhibited a significantly decreased risk (CT: adjusted odds ratio (OR=0.58, 95% confidence intervals (CI=0.37-0.91;adjusted OR=0.61, 95% CI=0.40-0.93 of mite-sensitized PER, while the AA genotype of rs2060793 in CYP2R1 exhibited a significantly increased risk (adjusted OR=1.85, 95% CI=1.03-3.34 of PER in the age subgroup of <16 years old. Both the AG and AG/GG genotypes of rs731236 in VDR exhibited a significantly decreased risk (AG: adjusted OR=0.43, 95% CI=0.21-0.89;adjusted OR=0.46, 95% CI=0.23-0.94 of PER in the female subgroup. Analysis of the locus-locus interactions of VDR and CYP2R1 revealed two models that involved combined SNPs of VDR and CYP2R1 were statistically significant (P<0.05. Our data suggest that age and gender may have an impact on the association of three SNPs (rs2228570, rs731236, and rs2060793 in genes of the vitamin D pathway with the risk of mite-sensitized PER in this Chinese population. The VDR and CYP2R1 variants may be involved in genetic interactions in the pathogenesis of PER.

  3. Anti-allergic rhinitis effect of caffeoylxanthiazonoside isolated from fruits of Xanthium strumarium L. in rodent animals.

    Science.gov (United States)

    Peng, Wei; Ming, Qian-Liang; Han, Ping; Zhang, Qiao-Yan; Jiang, Yi-Ping; Zheng, Cheng-Jian; Han, Ting; Qin, Lu-Ping

    2014-05-15

    The fruits of Xanthium strumarium L. (Asteraceae) have been used extensively in China for treatment of various diseases such as allergic rhinitis (AR), tympanitis, urticaria and arthritis or ozena. This study was designed to systemically investigate the effects of the caffeoylxanthiazonoside (CXT) isolated from fruits of X. strumarium on AR in rodent animals. Animals were orally administered with CXT. Anti-allergic activity of CXT was evaluated by passive cutaneous anaphylaxis test (PCA); acetic acid-induced writhing tests were used to evaluate the analgesic effects of CXT; acetic acid-induced vascular permeability tests were performed to evaluate anti-inflammatory effect of CXT. Then, the model AR in rats was established to evaluate the effects of CXT on AR with the following tests: the sneezing and nasal scratching frequencies, IgE level in serum, and histopathological examinations. Our results demonstrated that CXT had favorable anti-allergic, anti-inflammatory and analgesic effects. Additionally, we found that CXT was helpful to ameliorate the nasal symptoms and to down-regulate IgE levels in AR rats. Thus, we suggested that CXT can be treated as a candidate for treating AR. PMID:24613102

  4. Efficacy of intramuscular BCG polysaccharide nucleotide on mild to moderate bronchial asthma accompanied with allergic rhinitis: a randomized, double blind, placebo-controlled study

    Institute of Scientific and Technical Information of China (English)

    LI Jing; LUO Ding-fen; LI Sui-ying; SUN Bao-qing; ZHONG Nan-shan

    2005-01-01

    Background Atopy is a state of allergy to common antigens and is founded on an immune disturbance of exuberant Th2 activity and IgE production. There is also epidemiological and experimental evidence that exposure to mycobacteria has the potential to suppress the development of asthma or atopy. Since Th1 and Th2 immune mechanisms are significantly antagonistic, it is hypothesized that mycobacterial exposure may moderate atopic disease by modification of immune responses. Methods One hundred and twenty mild to moderate persistent asthmatics accompanied with allergic rhinitis were randomly divided into four groups with one injection every other day for 18 times for group A with 1 ml of normal saline, B with 0.5 mg of Bacillus Calmette-Guérin polysaccharide nucleotide (BCG-PSN) and C with 1 mg of BCG-PSN, 36 times for group D with 0.5 mg of BCG-PSN. Markers for the severity of asthma and rhinitis including the amount of inhaled corticosteriod, bronchodilator and oral H1 blocker-loratidine being used to obtain optimal symptomatic control, symptom scores of asthma and allergic rhinitis, peak expiratory flow (PEF), histamine provocative dose that produces at least a 20% change in forced expiratory volume with in 1 second (PD20-FEV1), blood IgE levels as well as dermatophagoides pteronysinus (DP) and dermatophagoides farinae (DF) skin prick test were measured every visit for 6 months. Results There were no differences for symptom scores of asthma, daily use of bronchodilator, PEF, PD20-FEV1, blood IgE as well as DF and DP skin prick test among the four groups. Score for allergic rhinitis decreased significantly in groups B, C and D on day 36 and 72 as compared with group A (P<0.05). Score for allergic rhinitis increased after day 72 in group B and C while it was significantly lower in group D (P<0.05). The patients in group D used less amount of inhaled beclomethosone than other groups (P<0.05) from day 72 after the treatment to day 180. Oral loratadine consumption in

  5. The effect of allergic rhinitis on the degree of stress, fatigue and quality of life in OSA patients.

    Science.gov (United States)

    Park, Cheol Eon; Shin, Seung Youp; Lee, Kun Hee; Cho, Joong Saeng; Kim, Sung Wan

    2012-09-01

    Both allergic rhinitis (AR) and obstructive sleep apnea (OSA) are known to increase stress and fatigue, but the result of their coexistence has not been studied. The objective of this study was to evaluate the amount of stress and fatigue when AR is combined with OSA. One hundred and twelve patients diagnosed with OSA by polysomnography were enrolled. Among them, 37 patients were diagnosed with AR by a skin prick test and symptoms (OSA-AR group) and 75 patients were classified into the OSA group since they tested negative for allergies. We evaluated the Epworth sleepiness scale (ESS), stress score, fatigue score, ability to cope with stress, and rhinosinusitis quality of life questionnaire (RQLQ) with questionnaires and statistically compared the scores of both groups. There were no significant differences in BMI and sleep parameters such as LSAT, AHI, and RERA between the two groups. However, the OSA-AR group showed a significantly higher ESS score compared to the OSA group (13.7 ± 4.7 vs. 9.3 ± 4.8). Fatigue scores were also significantly higher in the OSA-AR group than in the OSA group (39.8 ± 11.0 vs. 30.6 ± 5.4). The OSA-AR group had a significantly higher stress score (60.4 ± 18.6 vs. 51.2 ± 10.4). The ability to cope with stress was higher in the OSA group, although this difference was not statistically significant. RQLQ scores were higher in the OSA-AR group (60.2 ± 16.7 compared to 25.1 ± 13.9). In conclusion, management of allergic rhinitis is very important in treating OSA patients in order to eliminate stress and fatigue and to minimize daytime sleepiness and quality of life. PMID:22207526

  6. Inhibition of release of inflammatory mediators in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis

    Directory of Open Access Journals (Sweden)

    McPhee Sarah

    2007-02-01

    Full Text Available Abstract Background We demonstrated that a Chinese herbal formula, which we refer to as RCM-101, developed from a traditional Chinese medicine formula, reduced nasal and non-nasal symptoms of seasonal allergic rhinitis (SAR. The present study in primary and cultured cells was undertaken to investigate the effects of RCM-101 on the production/release of inflammatory mediators known to be involved in SAR. Methods Compound 48/80-induced histamine release was studied in rat peritoneal mast cells. Production of leukotriene B4 induced by the calcium ionophore A23187 was studied in porcine neutrophils using an HPLC assay and lipopolysaccharide-stimulated prostaglandin E2 production was studied in murine macrophage (Raw 264.7 cells by immune-enzyme assay. Expression of cyclooxygenase-1 (COX-1 and cyclooxygenase-2 (COX-2 was determined in Raw 264.7 cells, using western blotting techniques. Results RCM-101 (1–100 μg/mL produced concentration-dependent inhibition of compound 48/80-induced histamine release from rat peritoneal mast cells and of lipopolysaccharide-stimulated prostaglandin E2 release from Raw 264.7 cells. Over the range 1 – 10 μg/mL, it inhibited A23187-induced leukotriene B4 production in porcine neutrophils. In addition, RCM-101 (100 μg/mL inhibited the expression of COX-2 protein but did not affect that of COX-1. Conclusion The findings indicate that RCM-101 inhibits the release and/or synthesis of histamine, leukotriene B4 and prostaglandin E2 in cultured cells. These interactions of RCM-101 with multiple inflammatory mediators are likely to be related to its ability to reduce symptoms of allergic rhinitis.

  7. Association of allergic rhinitis or asthma with pollen and chemical pollutants in Szeged, Hungary, 1999-2007

    Science.gov (United States)

    Makra, László; Matyasovszky, István; Bálint, Beatrix; Csépe, Zoltán

    2014-07-01

    The effect of biological (pollen) and chemical air pollutants on respiratory hospital admissions for the Szeged region in Southern Hungary is analysed. A 9-year (1999-2007) database includes—besides daily number of respiratory hospital admissions—daily mean concentrations of CO, PM10, NO, NO2, O3 and SO2. Two pollen variables ( Ambrosia and total pollen excluding Ambrosia) are also included. The analysis was performed for patients with chronic respiratory complaints (allergic rhinitis or asthma bronchiale) for two age categories (adults and the elderly) of males and females. Factor analysis was performed to clarify the relative importance of the pollutant variables affecting respiratory complaints. Using selected low and high quantiles corresponding to probability distributions of respiratory hospital admissions, averages of two data sets of each air pollutant variable were evaluated. Elements of these data sets were chosen according to whether actual daily patient numbers were below or above their quantile value. A nonparametric regression technique was applied to discriminate between extreme and non-extreme numbers of respiratory admissions using pollen and chemical pollutants as explanatory variables. The strongest correlations between extreme patient numbers and pollutants can be observed during the pollen season of Ambrosia, while the pollen-free period exhibits the weakest relationships. The elderly group with asthma bronchiale is characterised by lower correlations between extreme patient numbers and pollutants compared to adults and allergic rhinitis, respectively. The ratio of the number of correct decisions on the exceedance of a quantile resulted in similar conclusions as those obtained by using multiple correlations.

  8. Rinite alérgica: aspectos epidemiológicos, diagnósticos e terapêuticos Allergic Rhinitis: epidemiological aspects, diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Cássio da Cunha Ibiapina

    2008-04-01

    Full Text Available Este estudo tem como objetivo revisar a literatura a respeito da rinite alérgica quanto aos aspectos epidemiológicos, clínicos, diagnósticos e terapêuticos. A revisão da bibliografia foi realizada utilizando-se as bases de dados Medline, Literatura Latino-Americana e do Caribe em Ciências da Saúde e HighWire, nos últimos trinta anos, utilizando-se os descritores allergic rhinitis, epidemiology, diagnosis, e treatment. Foram selecionados 60 artigos. Este estudo destaca o aumento na prevalência da rinite alérgica, sua associação com a asma, os critérios diagnósticos e seu tratamento. A classificação da rinite alérgica é apresentada, bem como as estratégias de tratamento. As modalidades terapêuticas apresentadas e discutidas são anti-histamínicos, corticóides, imunoterapia, antileucotrienos, cromoglicato dissódico e anticorpos anti-IgE, bem como a redução da exposição aos alérgenos. Finalmente, ressalta-se a importância da abordagem da rinite alérgica em saúde pública.This study was a review of the literature on the epidemiological, clinical, diagnostic and therapeutic aspects of allergic rhinitis. Bibliographic searches were based on the information contained within the Medline, Latin American and Caribbean Health Sciences Literature and HighWire databases, covering the last thirty years and using the following search terms: 'allergic rhinitis', 'epidemiology', 'diagnosis' and 'treatment'. Sixty articles were selected. This study describes the increase in the prevalence of allergic rhinitis, its relationship with asthma, the diagnostic criteria and the treatment. The classification of allergic rhinitis and strategies for its treatment are presented. Therapeutic modalities presented and discussed include the administration of antihistamines, corticosteroids, immunotherapy, anti-leukotrienes, sodium cromoglycate and anti-IgE antibodies, as well as minimizing exposure to inhaled allergens. Finally, the importance of

  9. Effect of RNA interference therapy on the mice eosinophils CCR3 gene and granule protein in the murine model of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    Xin-Hua Zhu; Bing Liao; Ke Liu; Yue-Hui Liu

    2014-01-01

    Objective:To observe the clinical manifestations of allergic rhinitis mice and the expression changes of the eosinophilsCCR3 and the granule protein mRNA in the bone marrow, peripheral blood and nasal lavage fluid.Methods:Twenty-fourBALB/c mice were randomly divided into the control group,PBS therapy group, siRNA therapy group and theCCR3 siRNA therapy group (n=6).Allergic rhinitis model were sensitized and stimulated by ovalbunfin, andCCR3 siRNA therapy group were administered withCCR3 transnasally before stimulated.The levels of the eosinophilsCCR3,MBP,ECP andEPO in bone marrow, peripheral blood and nasal lavage fluid were detected byRT-PCR.Results:Compared to the control group andCCR3 siRNA therapy group, the nasal mucosa of thePBS therapy group and siRNA therapy group developed epithalaxy, goblet cells hyperplasia, squamous epithelium metaplasia, epithelium necrosis, lamina propria and submucosa gland hyperplasia, vasodilatation, tissue edema, and the characterized eosinophil infiltration.RT-PCR indicated that theCCR3 mRNA,MBP ,ECP andEPO expression in bone marrow, peripheral blood and nasal lavage fluid of theCCR3 siRNA therapy group was lower than thePBS therapy group andsiRNA therapy group(P<0.05).Conclusions:TheRNA interference therapy toCCR3 by local administration pernasal can suppress the process of the development, migration and invasion of the allergic rhinitis eosinophil, thus can reduce the effect of eosinophils and then reduce the inflammation effect of the allergic rhinitis.It may be a new treatment for respiratory tract allergic inflammation.

  10. Imbalance of Peripheral Th17 and Regulatory T Cells in Children with Allergic Rhinitis and Bronchial Asthma.

    Science.gov (United States)

    Tao, Baohong; Ruan, Guiying; Wang, Dongguo; Li, Yong; Wang, Zhuping; Yin, Genquan

    2015-06-01

    The purpose of the present study is to investigate the prevalence of Th17 and regulatory T (Treg) cells in children with allergic rhinitis (AR) accompanying with bronchial asthma (BA). 24 children with AR, 22 children with BA, 18 children with AR accompanying with BA, and 20 healthy controls were recruited. The prevalence of peripheral blood Th17 and Treg cells were determined by flow cytometry. mRNA expression of retinoid-acid receptor-related orphan receptor (ROR)-γt and forkhead box P3 (Foxp3) were determined by realtime polymerase chain reaction. Cytokine expressions in plasma were determined by enzyme linked immunosorbent assay. The frequency of Th17 cells, ROR-γt mRNA expression, and the plasma levels of IL-17 were significantly higher, while Treg cells and Transforming growth factor (TGF)-β1 were significantly lower in children with AR accompanying with BA compared with those in children with AR or BA alone or control subjects. In children with allergic airway disease, total IgE levels were positively correlated to the frequency of Th17 cells (r=0.607, pTreg cells (r=-0.429, pTreg cells r=0.504, pTreg cells plays an important role in the pathogenesis of AR accompanying with BA. PMID:26546895

  11. Obesity is a risk factor for allergic rhinitis in children of Wuhan (China)

    OpenAIRE

    Lei, Yang; Yang, Huang; Zhen, Long

    2016-01-01

    Background The relationship between obesity and allergic diseases in children of China is unclear. Objective To analysis the relationship between obesity and overweight and the prevalence of allergic diseases and the impact of gender. Methods Questionnaire based on those used in National Study of Asthma and Allergies in Childhood in China. The study included 3,327 participants (23.7% aged 2–6 years, 65.8% aged 7–12 years, 10.5% aged 13–14 years) in Wuhan City. Allergic diseases were determine...

  12. New therapeutic strategies in allergic rhinitis%变应性鼻炎治疗新策略

    Institute of Scientific and Technical Information of China (English)

    沙骥超; 孟粹达; 修倩; 朱冬冬

    2016-01-01

    Allergic rhinitis (AR) is a nasal inflammatory,IgE-mediated disease that occurs when some individuals inhales something he or she is allergic to,such as pollen or animal dander.It is also a refractory disease with high prevalence in the field of rhinology.The treatment of AR is really a difficult and challenging task because of the high prevalence,economic burden and the interference to the quality of life.At present,nasal corticosteroid and antihistamines were the mainly therapies,however,there is up to 40% patients not satisfactory to these therapies.So exploring new therapy or target is necessary.This article will review the results of previous studies focused on the new therapies of AR.%变应性鼻炎(allergic rhinitis,AR)是机体吸入变应原后主要由IgE介导的鼻黏膜非感染性炎性疾病,是鼻科领域高患病率的难治性疾病.随着患病率的逐年增高,AR引起了一系列社会问题,包括对患者生活质量的影响、对工作、学习的干扰以及经济负担的逐渐加重.目前,AR的治疗任务及难度都面临着巨大的挑战,临床常用鼻用糖皮质激素和抗组胺药物控制鼻部症状,然而有研究显示,对疗效不满意的患者约高达40%.因而AR的治疗仍迫切需要开拓思路,探索新的有效治疗方法.本文对治疗AR新方法的临床研究进行综述.

  13. Clinical efficacy and tolerability of mometasone furoate nasal spray in perennial allergic rhinitis patients : an open multicentre study

    Directory of Open Access Journals (Sweden)

    Iwan Darmansjah

    2002-06-01

    Full Text Available Mometasone furoate (MF aqueous nasal spray has been shown to be effective and well-tolerated in the treatment of perennial allergic rhinitis (PAR. All of the sudies, however, have been conducted in Canada, UK, and Europe. Therefore, a bridging study is warranted in view of the different climatic conditions in tropical countries. To evaluate the clinical efficacy and tolerability of MF aqueous nasal spray in the treatment of PAR in a tropical country. This study was an open, non comparative, 4-week 3-centre trial in outpatients of 12 to 60 years with moderate to severe PAR of at least 2 years duration. Patients were allergic to at least one major PAR allergen, confirmed by skin prick test. They had total nasal symptom score (TNSS of ≥ 6 and nasal congestion score (NCS of ≥ 2 on ≥ 3 diary time points prior to baseline visit and at both screening and baseline visits. Eligible patients received MF aqueous nasal spray at baseline visit, and administered 200 µg mometasone every morning for 4 weeks. The primary clinical efficacy parameter was the mean percentage reduction of TNSS from baseline. Of 100 eligible patients, all completed this 4-week trial. The patient-evaluated TNSS (sum of the Last 3 mornings decreased signiftcantly from baseline with a mean reduction of 60.9 % (p < 0.0001, at week-2 and 73.6 % (p < 0.0001 at week-4. The mean reductions in physician-rated TNSS (61.7 % at week-2 and 77.8 % at week-4 were higher than those in the previous studies (43 % and 51 % at week-2, 52 % and 54 % at week-4. Similar trends were observed for nasal congestion score (NCS, other individual symptoms, total symptoms, and clinical efficacy rates. Evening symptoms were reduced similarly as morning symptoms There was no withdrawal due to adverse event. MF aqueous nasal spray, at a dose of 200 µg once daily in the morning for the treatment of moderate to severe PAR in a tropical country, was clinically effective with 24-hour control of

  14. Patients with asthma and comorbid allergic rhinitis: is optimal quality of life achievable in real life?

    Directory of Open Access Journals (Sweden)

    Fulvio Braido

    Full Text Available OBJECTIVES: Asthma trials suggest that patients reaching total disease control have an optimal Health Related Quality of Life (HRQoL. Moreover, rhinitis is present in almost 80% of asthmatics and impacts asthma control and patient HRQoL. We explored whether optimal HRQoL was reachable in a real-life setting, and evaluated the disease and patient related patterns associated to optimal HRQoL achievement. METHODS AND FINDINGS: Asthma and rhinitis HRQoL, illness perception, mood profiles, rhinitis symptoms and asthma control were assessed by means of validated tools in patients classified according to GINA and ARIA guidelines. Optimal HRQoL, identified by a Rhinasthma Global Summary (GS score ≤20 (score ranging from 0 to 100, where 100 represents the worst possible HRQoL, was reached by 78/209 (37.32%. With the exception of age, no associations were found between clinical and demographic characteristics and optimal HRQoL achievement. Patients reaching an optimal HRQoL differed in disease perception and mood compared to those not reaching an optimal HRQoL. Asthma control was significantly associated with optimal HRQoL (χ(2 = 49.599; p<0.001 and well-controlled and totally controlled patients significantly differed in achieving optimal HRQoL (χ(2 = 7.617; p<0.006. CONCLUSION: Approximately one third of the patients in our survey were found to have an optimal HRQoL. While unsatisfactory disease control was the primary reason why the remainder failed to attain optimal HRQoL, it is clear that illness perception and mood also played parts. Therefore, therapeutic plans should be directed not only toward achieving the best possible clinical control of asthma and comorbid rhinitis, but also to incorporating individualized elements according to patient-related characteristics.

  15. Efficacy of Sublingual Swallow Immunotherapy in Children with Rye Grass Pollen Allergic Rhinitis: A Double-blind Placebo-Controlled Study

    Directory of Open Access Journals (Sweden)

    Akefeh Ahmadiafshar

    2012-06-01

    Full Text Available Specific local immunotherapy has been recently introduced as an alternative to classic subcutaneous immunotherapy in treatment of allergic rhinitis. In this study, the effects of sublingual immunotherapy (SLIT on symptoms and medication score and skin prick test evaluation of patients with allergic rhinitis were investigated.In this placebo controlled trial, twenty four patients aged 5-18 years old with grass pollen induced rhinitis and sensitive to  rye grass by positive skin prick test received randomly sublingual extract of rye grass or placebo for 6 months. Symptom and medication scores and adverse effects of SLIT were assessed during treatment. Skin prick test induced wheal at the beginning and  the  end  of  therapy were also measured. Data  were analyzed with SPSS software.We found significant reduction of symptoms in intervention group from 21st  week of immunotherapy (p<0.05. Medication scores were also reduced after 16th  week (p<0.05, adverse effects were low and insignificant in both groups. Erythema induced diameter with skin  prick  test  for  grass  and  rye  grass  was  significantly reduced  in  SLI  group  after immunotherapy.This study indicates that SLIT in grass-pollen rhinitis is well tolerated, improves overall clinical symptoms,  and  reduces drug consumes.  We recommend  this  therapy as a safe therapy in patients with allergic rhinitis.

  16. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of Pycnogenol(R) for improving allergic rhinitis symptoms

    OpenAIRE

    Schonlau, Frank

    2010-01-01

    Abstract We explored the potential of Pycnogenol? for relieving allergic rhinitis (birch pollen) symptoms in a double-blind, placebo-controlled trial. In 2008 19 subjects started treatment three weeks prior to the onset of birch pollen season in Ontario Canada. While there was an improvement of eye and nasal symptoms with Pycnogenol, there was no significance versus placebo. It was postulated that Pycnogenol may require a lag-time between start of therapy and the onset of action. T...

  17. 支气管哮喘合并变应性鼻炎的流行病学调查%Epidemiological Studies of Asthma Complicated with Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    黎教武; 黄锦茵; 郭凤美; 方娟

    2014-01-01

    目的:了解佛山市顺德区乐从镇居民哮喘合并变应性鼻炎的流行现状。方法:采用整群随机抽样的方法,在佛山市顺德区乐从镇共抽取调查对象6906人,先由调查员筛查哮喘、可疑哮喘患者,然后由调研人员对可疑哮喘进一步的病史询问及检查。结果:乐从镇居民中,哮喘确诊72例,发病率为1.04%。男性患病率为0.95%,女性患病率为1.15%,两者比较差异无统计学意义(P>0.05)。自报变应性鼻炎患者588例,自报患病率为8.51%;男性患病率为10.19%,女性患病率为8.46%,两者比较差异有统计学意义(P0.05).588 residents reported allergic rhinitis.The self-reported prevalence of allergic rhinitis was 8.51%.The self-reported prevalence of allergic rhinitis in men was 10.19%,in women was 8.46%,there was statistical significance between the men and the women( χ²=4.626,P<0.05),the OR was 4.551.Conclusion:The prevalence of asthma complicated with allergic rhinitis of residents is higher than the asthma prevalence in Lecong town.

  18. Correlation of exhaled nitric oxide, nasal nitric oxide and atopic status: A cross-sectional study in bronchial asthma and allergic rhinitis

    OpenAIRE

    Nitesh Gupta; Nitin Goel; Raj Kumar

    2014-01-01

    Objective: Exhaled nitric oxide (FE NO ) and nasal nitric oxide (n NO) measurement is an area of ongoing research in the study of airway inflammation. The atopic status is known to influence the levels of FE NO and n NO. This study was undertaken to study the relationship between nitric oxide measurements in bronchial asthma and allergic rhinitis along with their correlation with atopic profile of Indian population. Materials and Methods: Ninety subjects were recruited for the study comprisin...

  19. How an online survey on the treatment of allergic rhinitis and its impact on asthma (ARIA) detected specialty-specific knowledge-gaps

    OpenAIRE

    Larenas Linnemann, Désirée ES; Medina Ávalos, Miguel Alejandro; Lozano Sáenz, José

    2015-01-01

    Background To enhance the dissemination of the ARIA document (Allergic rhinitis (AR) and its impact on asthma) in Mexico, a Working Group composed of 35 specialists of 8 professional medical societies developed a transculturized ARIA México 2014 guideline. The ARIA guidelines use the GRADE system, which builds recommendations and suggestions around clinical questions (CQ). Methods As part of the dissemination strategy and to detect the physicians’ view and knowledge-gaps concerning the treatm...

  20. Elevated levels of manna-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associated with a novel intronic polymorphism in MBL

    DEFF Research Database (Denmark)

    Kaur, S.; Gupta, G.K.; Shah, A.;

    2006-01-01

    Mannan-binding lectin (MBL), an important component of innate immunity, binds to a range of foreign antigens and initiates the lectin complement pathway. Earlier studies have reported high plasma MBL levels in allergic patients in comparison to healthy controls. In view of varied plasma MBL levels...... being determined by genetic polymorphisms in its collagen region, we investigated the association of single nucleotide polymorphisms (SNPs) in the collagen region of human MBL with respiratory allergic diseases. The study groups comprised patients of bronchial asthma with allergic rhinitis (n = 49......) and allergic bronchopulmonary aspergillosis (APBA) (n = 11) and unrelated age-matched healthy controls of Indian origin (n = 84). A novel intronic SNP, G1011A of MBL, showed a significant association with both the patient groups in comparison to the controls (P

  1. Air pollution from livestock farms, and asthma, allergic rhinitis and COPD among neighbouring residents.

    NARCIS (Netherlands)

    Smit, L.A.M.; Hooiveld, M.; Sman-de Beer, F. van der; Opstal-van Winden, A.W.J.; Beekhuizen, J.; Wouters, I.M.; Yzermans, J.; Heederik, D.

    2014-01-01

    Objectives: There is an ongoing debate regarding environmental health risks of exposures to dust and microbial agents from livestock farming in the Netherlands. The aims of the study were (1) to investigate associations between indicators of air pollution from livestock farms and asthma, allergic rh

  2. Trichuris suis ova therapy for allergic rhinitis

    DEFF Research Database (Denmark)

    Bager, Peter; Arnved, John; Rønborg, Steen;

    2010-01-01

    Parasitic helminth infections can protect against allergic airway inflammation in experimental models and have been associated with a reduced risk of atopy and a reduced course of asthma in some observational studies. Although no clinical evidence exists to support the use of helminth therapy for...

  3. Air pollution from livestock farms, and asthma, allergic rhinitis and COPD among neighbouring residents

    NARCIS (Netherlands)

    Smit, Lidwien A M; Hooiveld, Mariëtte; van der Sman-de Beer, Femke; Opstal-van Winden, Annemieke W J; Beekhuizen, Johan; Wouters, Inge M; Yzermans, C Joris; Heederik, Dick

    2014-01-01

    OBJECTIVES: There is an ongoing debate regarding environmental health risks of exposures to dust and microbial agents from livestock farming in the Netherlands. The aims of the study were (1) to investigate associations between indicators of air pollution from livestock farms and asthma, allergic rh

  4. IL4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients

    NARCIS (Netherlands)

    Micheal, S.; Minhas, K.; Ishaque, M.; Ahmed, F.; Ahmed, A.

    2013-01-01

    Background and Objective: Interleukin (IL) 4 is a cytokine that mediates allergic responses. Different single nucleotide polymorphisms (SNPs) can influence the immune response mediated by cytokines. The aim of the present study was to investigate the possible association between IL-4 polymorphisms a

  5. Clinical Profile, Co-Morbidities and Health Related Quality of Life in Pediatric Patients with Allergic Rhinitis and Asthma

    Directory of Open Access Journals (Sweden)

    Keya R. Lahiri, Milind S. Tullu* and Rachna Kalra

    2010-10-01

    Full Text Available Background: Co-existence of allergic rhinitis (AR and bronchial asthma (BA is well known. We planned to study the clinical profile of patients with AR & BA, the associated co-morbidities and the effect of AR &/ or BA on health related quality of life (HRQOL in Pediatric patients. Methods: Patients attending the Pediatric out-patients department and Pediatric Chest Clinic of tertiary care center were enrolled. The sample size included 100 subjects with BA & AR (Group 1 with control groups of 60 asthmatic children (Group 2 & 40 children suffering from AR (Group 3. The patients were subjected to a questionnaire & a through physical examination and the details were recorded in a pre-designed proforma. General medical, environmental, occupational, personal & family history was procured along with examination of respiratory system. The standard heath related quality of life (HRQOL parameters were studied. Findings: The study was conducted over a period of 13 months (February 2004 to March 2005. 200 patients between ages of 3 to 15 years (mean 7.95 years were enrolled (100 patients with BA and AR- group 1, 60 patients with asthma alone- group 2 and 40 patients with AR alone- group 3. Dust, smoke, outdoor dust, holi festival, winter season, exercise, and smoking by father were important exacerbating factors in all the three groups. Additionally, diwali festival and family history of asthma were important in Group 2 (BA; while pollen, weeds, diwali festival and family history of allergic rhinitis were important causes of exacerbation in group 3 (AR. Cough was commonly seen in all three groups. Wheezing, sneezing, itching throat, rhinorrhea, watering, altered taste, and nasal block was common in patients in group 1 while wheezing was important symptom in patients in group 2 (BA. Sneezing, itching throat, rhinorrhea, watering, altered taste, and nasal block were common symptoms in patients in group 3 (AR. Conjunctivitis, pharyngitis, and post-nasal drip

  6. Association pattern of interleukin-1 receptor-associated kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese population.

    Directory of Open Access Journals (Sweden)

    Yuan Zhang

    Full Text Available OBJECTIVE: Interleukin-1 receptor-associated kinase-4 (IRAK-4 encodes a kinase that is essential for NF-kB activation in Toll-like receptor and T-cell receptor signaling pathways, indicating a possible crosstalk between innate and acquired immunities. We attempted to determine whether the polymorphisms in the Interleukin-1 receptor-associated kinase-4 (IRAK-4 gene are associated with allergic rhinitis (AR in the Han Chinese population. METHODS: A population of 379 patients with AR and 333 healthy controls was studied. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE. A total of 11 single nucleotide polymorphisms (SNPs in IRAK-4 were selected and individually genotyped. RESULTS: Significant allelic differences between cases and controls were obtained for the SNP of rs3794262 in the IRAK-4 gene. In the stratified analysis for gender, two SNPs (rs4251431 and rs6582484 in males appeared as significant associations. Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262, rs4251481. None of the selected SNPs in IRAK-4 was associated with total IgE level. The haplotype analysis indicated GCCTGCGA was significantly associated with AR. The SNP-SNP interaction information analysis indicated that the selected sets of polymorphisms had no synergistic effect. CONCLUSIONS: Our findings did not support the potential contribution of the IRAK-4 gene to serum IgE levels. However, the results demonstrated a gender- and allergen-dependant association pattern between polymorphisms in IRAK-4 and AR in Chinese population.

  7. Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population.

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    Di Hu

    Full Text Available OBJECTIVE: Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR in the Chinese Han population. METHODS: We included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP. RESULTS: A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (P<0.001. In addition, substantially high frequencies of the GGCA and GGCG haplotypes were observed in the AR patients, unlike that observed in the control individuals (P<0.05. The results suggest that the AGTG haplotype may provide protection against AR (P<0.001. CONCLUSIONS: To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Chinese Han population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified.

  8. Occupational Rhinitis.

    Science.gov (United States)

    Grammer, Leslie C

    2016-05-01

    Occupational rhinitis (OR) involves nasal congestion, rhinorrhea, nasal itching, and/or sneezing resulting from workplace exposures. OR can have a significant negative effect on quality of life and productivity. OR can be divided into allergic or nonallergic subgroups based on the underlying pathogenesis. Certain occupational exposures place employees at greater risk for developing disease. Primary treatment is avoidance of implicated exposures. Antihistamines, saline rinses, and nasal steroids may be useful. OR can coexist with occupational asthma, and rhinitis symptoms have been reported to precede those of the lower respiratory tract. OR is has both medical and socioeconomic implications. PMID:27083106

  9. Occupational allergic rhinitis and contact urticaria caused by bishop's weed (Ammi majus).

    Science.gov (United States)

    Kiistala, R; Mäkinen-Kiljunen, S; Heikkinen, K; Rinne, J; Haahtela, T

    1999-06-01

    Bishop's weed (Ammi majus) has been known to induce toxic phytophotodermatitis. We now describe IgE-mediated rhinitis and contact urticaria caused by exposure to bishop's weed in a 31-year-old atopic female florist. A skin prick-prick test with bishop's weed flowers gave an 8-mm wheal, and the bishop's weed-specific IgE level in the patient's serum was 9.7 PRU/ml (RAST class 3). In an immunoblotting experiment with the patient's serum, nine IgE-binding protein bands with the molecular weights 19, 34, 39-41 (doublet), 52-61 (doublet), and >67 (triplet) kDa were detected in bishop's weed extract. The patient became symptomless after she had ceased to work as a florist.

  10. [Comparative characterization of the microflora of the upper respiratory tract mucous membranes in bronchial asthma and allergic persistent rhinitis].

    Science.gov (United States)

    Romanenko, E E; Baturo, A P; Ulisko, I N

    2005-01-01

    A total of 250 patients with diagnosed bronchial asthma (BA) were examined by microbiological methods. Among them--188 children and 62 adults. In 87 patients the microflora of nasal mucosa was studied, in 40--of pharynx only and in 123 patients--both the nasal and the pharynx. For comparative analysis earlier data obtained in 69 patients with persistent allergic rhinitis (PAR) were used. The cultures isolated from the nasal mucosa of BA patients were shown to number 18 genera and 42 species, while among those isolated from pharynx mucosa 20 genera and 40 species. Monocultures were isolated from the nasal mucosa only in 23% of the examined patients and from the pharynx mucosa--only in 1.42%. Associations with different numbers of components were isolated from nasal and pharynx mucosa (2 to 6, 2 to 8 respectively). Staphylococcus aureus was regarded as the main species of nasal biocenosis in BA and PAR, as well as pharynx biocenosis in BA. Besides, in BA other Staphylococcus species (schleiferi, caprae, capitis, hominis, etc.), reversely related to the main species, could be isolated from both mucous membranes. Similarities and differences in microflora of biocenoses in both nosological forms, confirming links between PAR and BA, are considered. PMID:15881942

  11. Justification of advisability of using physical factors in the treatment of patients with allergic rhinitis and associated bronchial asthma

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    T. N. Zaripova

    2012-01-01

    Full Text Available The efficiency of treatment of patients with allergic rhinitis and associated bronchial asthma by physical factors and advisability of two-stage treatment are justified. Sixty six patients were observed. The conclusion on the efficiency of treatment was based on the data about the dynamics clinical state of the primary and associated diseases, intensity of inflammation activity in respiratory tract (rhinocytograms, biochemical indices of nasal lavages, level of nitrogen oxide in expired air were studied, patency of airways (manometry, spirography. We compared two versions of treatment: two- and one-stage. Patients of the first group (30 patients received elimination therapy for 3 to 5 days with the following peaty mud application, current of supersonic frequency, massage, inhalations, physical therapy. Patients of the second group (36 patients did not receive elimination therapy. We have found a decrease in intensity of clinical implications of the primary and associated diseases, decrease in inflammation activity, better nasal and bronchial носовой patency, improvement of the mucociliary function in patients of the first group. In the second group, the recovery of the surface epithelium and nasal patency was not observed against the background of improvement of the clinical state.

  12. Inhibition of Release of Vasoactive and Inflammatory Mediators in Airway and Vascular Tissues and Macrophages by a Chinese Herbal Medicine Formula for Allergic Rhinitis

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    George Binh Lenon

    2007-01-01

    Full Text Available Herbal therapies are being used increasingly for the treatment of allergic rhinitis. The aim of this study was to investigate the possible pharmacological actions and cellular targets of a Chinese herbal formula (RCM-101, which was previously shown to be effective in reducing seasonal allergic rhinitis symptoms in a randomized, placebo-controlled clinical trial. Rat and guinea pig isolated tissues (trachea and aorta were used to study the effects of RCM-101 on responses to various mediators. Production of leukotriene B4 in porcine neutrophils and of prostaglandin E2 and nitric oxide (NO in Raw 264.7 cells were also measured. In rat and guinea pig tracheal preparations, RCM-101 inhibited contractile responses to compound 48/80 but not those to histamine (guinea pig preparations or serotonin (rat preparations. Contractile responses of guinea pig tracheal preparations to carbachol and leukotriene C4, and relaxant responses to substance P and prostaglandin E2 were not affected by RCM-101. In rat aortic preparations, precontracted with phenylephrine, endothelium-dependent relaxant responses to acetylcholine and endothelium-independent relaxant responses to sodium nitroprusside were not affected by RCM-101. However, RCM-101 inhibited relaxations to l-arginine in endothelium-denuded rat aortic preparations, which had been pre-incubated with lipopolysaccharide. RCM-101 did not affect leukotriene B4 formation in isolated porcine neutrophils, induced by the calcium ionophore A23187; however, it inhibited prostaglandin E2 and NO production in lipopolysaccharide-stimulated murine macrophages (Raw 264.7 cells.The findings indicate that RCM-101 may have multiple inhibitory actions on the release and/or synthesis of inflammatory mediators involved in allergic rhinitis.

  13. Imbalance of Peripheral Th17 and Regulatory T Cells in Children with Allergic Rhinitis and Bronchial Asthma

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    Baohong Tao

    2015-10-01

    Full Text Available The purpose of the present study is to investigate the prevalence of Th17 and regulatory T (Treg cells in children with allergic rhinitis (AR accompanying with bronchial asthma (BA.24 children with AR, 22 children with BA, 18 children with AR accompanying with BA,and 20 healthy controls were recruited. The prevalence of peripheral blood Th17 and Treg cells were determined by flow cytometry. mRNA expression of retinoid-acid receptor-related orphan  receptor  (ROR-γt  and  forkhead  box  P3  (Foxp3 were  determined  by  realtime polymerase chain reaction. Cytokine expressions in plasma were determined by enzyme linked immunosorbent assay.The frequency of Th17 cells, ROR-γt mRNA expression, and the plasma levels of IL-17 were significantly higher, while Treg cells and Transforming growth factor (TGF-β1 were significantly lower in children with AR accompanying with BA compared with those in children with AR or BA alone or control subjects. In children with allergic airway disease, total IgE levels were positively correlated to the frequency of Th17 cells (r=0.607, p<0.01, plasma IL-17 levels, and negatively correlated to the frequency of Treg cells (r=-0.429, p<0.01 and TGF-β1 levels (r=-0.224, p<0.01. While Forced expiratory volume in one second (FEV1 (% predicted was negatively correlated to the frequency of Th17 cells (r=-0.602, p<0.01, plasma IL-17 levels (r=-0.577,  p<0.01, and positively correlated to  the frequency of Treg cells (r=0.504, p<0.01 and TGF-β1 levels (r=0.231, p<0.05.Our  results  demonstrate  that  the  imbalance  of  peripheral Th17/Treg  cells  plays  an important role in the pathogenesis of AR accompanying with BA.

  14. Evaluation of serum specific IgE for the diagnosis of allergic rhinitis with multi-allergens

    Institute of Scientific and Technical Information of China (English)

    LIU Cheng-yao; ZHANG Yuan; HAN De-min; ZHANG Luo

    2010-01-01

    Background Objective evaluation of allergic rhinitis (AR) requires in vivo and in vitro tests. In vitro tests are important to assist or ensure the main allergens in multi-allergen-sensitive patients. The aim of this study was to evaluate the utility of serum specific IgE (slgE) in the diagnosis of AR patients with multi-allergens in the Chinese population.Methods Combining a positive skin prick test (SPT) and clinical history as the diagnostic reference criteria of AR, we estimated concentrations of slgE produced in response to the 7 most frequent allergens among 85 AR patients, using the UniCAP assay system.Results Among 85 individuals with positive SPT results and allergen-specific nasal symptoms, slgE concentration correlated well with SPT classes among all the tested allergens. Based on a clinical diagnosis and SPT results using a positive cut-off value of a class 1 score, the CAP test performed well and the sensitivity for different allergens ranged from 0.5 (giant ragweed) to 0.91 (Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f), while specificity ranged from 0.93 (Der f) to 1.0 (animal hair, Derp and mugwort). When the cut-off score was adjusted to class 2, the sensitivity showed an increase overall while the remaining assessed items, including specificity, positive predictive value, negative predictive value and efficiency, showed an unacceptable decline.Conclusions Well-established serum slgE tests correlated well with SPTs. Setting a class 1 cut-off for positivity of SPT results was better than a class 2 setting for assessing the AR diagnostic value.

  15. Epidemiological characterization and risk factors of allergic rhinitis in the general population in Guangzhou City in china.

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    Chun Wei Li

    Full Text Available The prevalence of allergic rhinitis (AR in China has increased with an apparent geographic variation. The current study aims to investigate the AR prevalence/classification, diagnosis/treatment conditions, trigger factors, and risk factors in the general population of Guangzhou, the third biggest city in China. A cross-sectional survey was performed in the citizens in Guangzhou from December 2009 to March 2010 by using a stratified multistage cluster sampling method. All subjects were asked to complete a comprehensive questionnaire via a face to face interview. A total of 9,899 questionnaires were valid. The prevalence rate of AR in the general population of Guangzhou was 6.24%, with a significant higher prevalence in urban area (8.32% versus rural area (3.43%. Among the AR subjects, most (87% were diagnosed with intermittent AR and 87% suffered from moderate-severe symptoms. High percentages of the AR patients did not have previously physician-based diagnosis (34% or specific medical treatment (55%. Morning time, winter season, and cold air were the most common trigger factors of AR. Family history of AR, current living place, living place during babyhood, smoking, home renovation, and pet ownership were the significant risk factors associated with AR prevalence in the population. The study demonstrated comprehensive epidemiological and clinical information about the AR in Guangzhou population. Change of living environment and lifestyles had strong impacts on the prevalence of AR. Public health policies should help the patients benefit from a proper diagnosis/treatment and specifically target the local risk factors, in order to control the AR incidence.

  16. Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

    Science.gov (United States)

    Zhu, Zheng; Xie, Yanqing; Guan, Weijie; Gao, Yi; Xia, Shu; Shi, Xu

    2016-01-01

    Background The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear. Objective To evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR. Methods Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week. The correlations between nasal challenge tests induced nasal responses and QoL in RQoLQ were analyzed. Results A total of 25 eligible AR patients enrolled and finished both LTD4 and histamine nasal challenge and completed the questionnaire of RQoLQ. Histamine nasal challenge induced sneezing, increased nasal resistant were correlated with most of the dimensions (general, practical, nasal, eye problems, and quality of sleep, p < 0.05), while LTD4 nasal challenge induced sneeze, increased nasal resistant only correlated with nasal and ocular problems. On the contrary, the severity of the sneeze assessed by TSS4, was not correlated with QoL, while the severity of rhinorrhea, congestion, and nasal pruritus were correlated with nasal and practical problems, and nasal congestion was also correlated with ocular problems (r = 0.60, p = 0.01). Conclusion LTD4 and histamine nasal challenge induced nasal responses were correlated with different clinical symptoms severity and QoL, which can be used as a good diagnosis and evaluation methods for the management of AR.

  17. Polymorphic variants of interleukin-13 R130Q, interleukin-4 T589C, interleukin-4RA I50V, and interleukin-4RA Q576R in allergic rhinitis: A pilot study

    OpenAIRE

    Yadav, Aravind; Govindasamy, Gopala Krishnan; Naidu, Rakesh

    2012-01-01

    The development of allergic rhinitis is considered to be caused by the complex interactions between genetic predisposition and environmental factors. Polymorphisms in the interleukin (IL)-13/4/4RA pathway have previously been shown to be associated with atopic diseases. The purpose of this study was to determine the association between IL-13 R130Q, IL-4 T589C, IL4 receptor alpha (IL-4RA) I50V, or IL-4RA Q576R polymorphisms and risk of allergic rhinitis in a hospital-based Malaysian population...

  18. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts : an allergic comorbidity cluster

    NARCIS (Netherlands)

    Garcia-Aymerich, J.; Benet, M.; Saeys, Y.; Pinart, M.; Basagana, X.; Smit, H. A.; Siroux, V.; Just, J.; Momas, I.; Ranciere, F.; Keil, T.; Hohmann, C.; Lau, S.; Wahn, U.; Heinrich, J.; Tischer, C. G.; Fantini, M. P.; Lenzi, J.; Porta, D.; Koppelman, G. H.; Postma, D. S.; Berdel, D.; Koletzko, S.; Kerkhof, M.; Gehring, U.; Wickman, M.; Melen, E.; Hallberg, J.; Bindslev-Jensen, C.; Eller, E.; Kull, I.; Carlsen, K. C. Lodrup; Carlsen, K. -H.; Lambrecht, B. N.; Kogevinas, M.; Sunyer, J.; Kauffmann, F.; Bousquet, J.; Anto, J. M.

    2015-01-01

    BackgroundAsthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques. MethodsWe included 17209 children at 4years

  19. 三联疗法治疗过敏性鼻炎疗效观察%Clinical observation on treating allergic rhinitis with the Sanlian therapy

    Institute of Scientific and Technical Information of China (English)

    张茂亮

    2013-01-01

    Allergic rhinitis is a common disease, sneezing, nasal itching, runny nose and nasal congestion are the four most common symptoms, usually caused by exposure to pollen, dust and cold air, often causing dizziness, headache, suffocation and other symptoms. Seriously affected daily life and work; and the disease easily relapse. The author used the Sanlian therapy to treat allergic rhinitis and achieved a more satisfactory outcome, reported as follows.%过敏性鼻炎是临床常见病之一,喷嚏、鼻痒、流涕和鼻塞是最常见的四大症状。多因接触花粉、尘土及冷空气等诱发,常引起头昏,头痛;憋气窒息等症状,严重影响日常生活和工作;且此病较易复发。笔者采用三联疗法治疗过敏性鼻炎,取得较满意疗效,报道如下。

  20. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US.

    Science.gov (United States)

    Mudarri, David H

    2016-01-01

    Two foundational methods for estimating the total economic burden of disease are cost of illness (COI) and willingness to pay (WTP). WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$) of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3-4.7) billion for allergic rhinitis, $1.9 (1.1-2.3) billion for acute bronchitis, $15.1 (9.4-20.6) billion for asthma morbidity, and $1.7 (0.4-4.5) billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality. PMID:27313630

  1. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Directory of Open Access Journals (Sweden)

    David H. Mudarri

    2016-01-01

    Full Text Available Two foundational methods for estimating the total economic burden of disease are cost of illness (COI and willingness to pay (WTP. WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$ of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7 billion for allergic rhinitis, $1.9 (1.1–2.3 billion for acute bronchitis, $15.1 (9.4–20.6 billion for asthma morbidity, and $1.7 (0.4–4.5 billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality.

  2. Noninterventional Open-Label Trial Investigating the Efficacy and Safety of Ectoine Containing Nasal Spray in Comparison with Beclomethasone Nasal Spray in Patients with Allergic Rhinitis

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    Uwe Sonnemann

    2014-01-01

    Full Text Available Objectives. The current study aimed to compare the efficacy and safety of a classical anti-inflammatory beclomethasone nasal spray in comparison to a physic-chemical stabilizing ectoine containing nasal spray in the treatment of allergic rhinitis. Design and Methods. This was a noninterventional, open-label, observational trial investigating the effects of beclomethasone or ectoine nasal spray on nasal symptoms and quality of life. Over a period of 14 days, patients were asked to daily document their symptoms. Efficacy and tolerability were assessed by both physicians and patients. Results. Both treatments resulted in a significant decrease of TNSS values. An equivalence test could not confirm the noninferiority of ectoine treatment in comparison with beclomethasone treatment. Although clear symptom reduction was achieved with the ectoine products, the efficacy judgment showed possible advantages for the beclomethasone group. Importantly, tolerability results were comparably good in both groups, and a very low number of adverse events supported this observation. Both treatments resulted in a clear improvement in the quality of life as assessed by a questionnaire answered at the beginning and at the end of the trial. Conclusion. Taken together, it was shown that allergic rhinitis can be safely and successfully treated with beclomethasone and also efficacy and safety were shown for ectoine nasal spray.

  3. Measuring outcomes in allergic rhinitis: psychometric characteristics of a Spanish version of the congestion quantifier seven-item test (CQ7

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    Mullol Joaquim

    2011-03-01

    Full Text Available Abstract Background No control tools for nasal congestion (NC are currently available in Spanish. This study aimed to adapt and validate the Congestion Quantifier Seven Item Test (CQ7 for Spain. Methods CQ7 was adapted from English following international guidelines. The instrument was validated in an observational, prospective study in allergic rhinitis patients with NC (N = 166 and a control group without NC (N = 35. Participants completed the CQ7, MOS sleep questionnaire, and a measure of psychological well-being (PGWBI. Clinical data included NC severity rating, acoustic rhinometry, and total symptom score (TSS. Internal consistency was assessed using Cronbach's alpha and test-retest reliability using the intraclass correlation coefficient (ICC. Construct validity was tested by examining correlations with other outcome measures and ability to discriminate between groups classified by NC severity. Sensitivity and specificity were assessed using Area under the Receiver Operating Curve (AUC and responsiveness over time using effect sizes (ES. Results Cronbach's alpha for the CQ7 was 0.92, and the ICC was 0.81, indicating good reliability. CQ7 correlated most strongly with the TSS (r = 0.60, p Conclusions The Spanish version of the CQ7 is appropriate for detecting, measuring, and monitoring NC in allergic rhinitis patients.

  4. Montelukast as Add-On Therapy with Inhaled Corticosteroids or Inhaled Corticosteroids and Long-Acting Beta-2-Agonists in the Management of Patients Diagnosed with Asthma and Concurrent Allergic Rhinitis (The RADAR Trial

    Directory of Open Access Journals (Sweden)

    Paul K Keith

    2009-01-01

    Full Text Available OBJECTIVE: To evaluate the effectiveness of montelukast as add-on therapy for patients diagnosed with asthma and concurrent allergic rhinitis who remain uncontrolled while receiving inhaled corticosteroid (ICS monotherapy or ICS/long-acting beta-2-agonist (LABA therapy in a community practice setting.

  5. 'Help for Hay Fever', a goal-focused intervention for people with intermittent allergic rhinitis, delivered in Scottish community pharmacies: study protocol for a pilot cluster randomized controlled trial

    NARCIS (Netherlands)

    Porteous, T.; Wyke, S.; Smith, S.; Bond, C.; Francis, J.; Lee, A.J.; Lowrie, R.; Scotland, G.; Sheikh, A.; Thomas, M.; Smith, Lorraine

    2013-01-01

    BACKGROUND: Despite the availability of evidence-based guidelines for managing allergic rhinitis in primary care, management of the condition in the United Kingdom (UK) remains sub-optimal. Its high prevalence and negative effects on quality of life, school performance, productivity and co-morbid re

  6. Allergen-specific regulation of allergic rhinitis in mice by intranasal exposure to IgG1 monoclonal antibody Fab fragments against pathogenic allergen.

    Science.gov (United States)

    Matsuoka, Daiko; Mizutani, Nobuaki; Sae-Wong, Chutha; Yoshino, Shin

    2014-09-01

    Fab fragments (Fabs) have the ability to bind to specific antigens but lack the Fc portion for binding to receptors on immune and inflammatory cells that play a critical role in allergic diseases. In the present study, we investigated whether Fabs of an allergen-specific IgG1 monoclonal antibody (mAb) inhibited allergic rhinitis in mice. BALB/c mice sensitized by intraperitoneal injections of ovalbumin (OVA) plus alum on days 0 and 14 were intranasally challenged with OVA on days 28-30, and 35. Fabs prepared by the digestion of an anti-OVA IgG1 mAb (O1-10) with papain were also intranasally administered 15min before each OVA challenge. The results showed that treatment with O1-10 Fabs significantly suppressed the sneezing frequency, associated with decrease of OVA-specific IgE in the serum and infiltration by mast cells in the nasal mucosa seen following the fourth antigenic challenge; additionally, the level of mouse mast cell protease-1, a marker of mast cell activation, in serum was decreased. Furthermore, infiltration of eosinophils and goblet cell hyperplasia in the nasal mucosa at the fourth challenge were inhibited by treatment with O1-10 Fabs. In conclusion, these results suggest that intranasal exposure to Fabs of a pathogenic antigen-specific IgG1 mAb may be effective in regulating allergic rhinitis through allergen capture by Fabs in the nasal mucosa before the interaction of the intact antibody and allergen.

  7. Therapeutic Observation of Mind-concentration Acupuncture for Allergic Rhinitis%意守针法治疗过敏性鼻炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    缪奇祥

    2015-01-01

    目的:观察意守针法治疗过敏性鼻炎的临床疗效。方法将54例过敏性鼻炎患者随机分为治疗组28例和对照组26例。治疗组采用意守针法治疗,对照组采用常规药物治疗。比较两组临床疗效及复发率。结果治疗组总有效率为82.1%,对照组为76.9%,两组比较差异具有统计学意义(P<0.05)。治疗组治疗后1年复发率为28.6%,对照组为75.0%,两组比较差异具有统计学意义(P<0.01)。结论意守针法是一种治疗过敏性鼻炎的有效方法。%Objective To observe the therapeutic efficacy of mind-concentration acupuncture in treating allergic rhinitis. Methods Fifty-four patients with allergic rhinitis were randomized into a treatment group of 28 cases and a control group of 26 cases. The treatment group was intervened by mind-concentration acupuncture, while the control group was by conventional medication. The therapeutic efficacies and relapse rate were compared afterwards. Results The total effective rate was 82.1%in the treatment group versus 76.9%in the control group, and the difference was statistically significant (P<0.05). A year later, the relapse rate was 28.6%in the treatment group versus 75.0%in the control group, and the difference was statistically significant (P<0.01). Conclusion Mind-concentration acupuncture is an effective approach in treating allergic rhinitis.

  8. The influence of lifestyle intervention on patients with allergic rhinitis%生活方式干预对过敏性鼻炎患者的影响

    Institute of Scientific and Technical Information of China (English)

    吴美芝; 揭桂莲; 吴凤玲

    2014-01-01

    目的:探讨生活方式干预对过敏性鼻炎患者的影响。方法将116例过敏性鼻炎患者随机分为实验组和对照组,每组各58例,对照组给予常规对症护理,实验组在对照组的基础上给予生活方式干预,采用生活方式情况评价表、治疗效果评价表对两组患者干预前、干预1年后的生活方式情况、治疗效果进行比较。结果与干预前比较,干预1年后实验组的生活方式情况、治疗效果明显优于对照组,差异有统计学意义( P<0.05)。结论生活方式干预有利于过敏性鼻炎患者建立健康的生活方式,提高治疗效果,从而进一步提高患者的生活质量。%Objective To investigate the influence of lifestyle intervention on patients with allergic rhinitis. Methods 116 cases with allergic rhinitis were randomly divided into the experimental group and the control group, each group had 58 cases, the control group was given general symptomatic care, the experimental group was given lifestyle intervention based on the control group, compared the lifestyle and clinical efficacy of the two groups before intervention and 1 year after intervention by lifestyle evaluation form and treatment evaluation form. Results Compared with before the intervention,the lifestyle and clinical efficacy of the experimental group were significantly better than the control group 1 year after intervention.The difference had statistically significant(P < 0.05). Conclusion It is conducive to lead a healthy lifestyle for patients with allergic rhinitis by lifestyle intervention, improve the therapeutic effect, thereby further improving the patients' life quality.

  9. Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma

    DEFF Research Database (Denmark)

    Maloney, J; Durham, S; Skoner, D;

    2015-01-01

    % and 31%, respectively, had reported asthma. No serious local allergic swellings or serious systemic allergic reactions occurred in subjects with asthma treated with SLIT-tablet. There was no evidence of increased TEAEs, systemic allergic reactions, or severe local allergic swellings in adults or children....../without conjunctivitis (AR/C), AE frequencies were determined in adults and children with and without reported asthma. METHODS: Data from randomized, double-blind, placebo-controlled trials of Timothy grass SLIT-tablet MK-7243 (2800 BAU/75 000 SQ-T, Merck/ALK-Abelló) were pooled for post hoc analyses. Subjects...... with uncontrolled and severe asthma were excluded from the trials. Frequencies for treatment-emergent AEs (TEAEs), local allergic swelling (mouth or throat), systemic allergic reactions, and asthma-related treatment-related AEs (TRAEs) were calculated. RESULTS: Among adults (n = 3314) and children (n = 881), 24...

  10. Professor Yu Jingmao' s experience in treating childhood allergic rhinitis%俞景茂治疗小儿变应性鼻炎经验撷英

    Institute of Scientific and Technical Information of China (English)

    李岚

    2011-01-01

    总结俞景茂教授辨治小儿变应性鼻炎临床经验.俞教授认为本虚标实、寒热夹杂为其病机特点,宜以寒温并用、攻补兼施,结合疏风活血为法治疗.%This article presents Professor Yu Jingmao' s clinical experience in treating childhood allergic rhinitis by Chinese medicine. Professor Yu suggests that the pathogenesis of this disease is root deficiency and tip excess, and cold-heat complex; and the treatment should focus on using warming and heat-clearing simultane-ously, reinforcement and elimination in combination, also dispelling pathogenic wind and activating blood.

  11. Alcohol consumption and the risk of self-reported perennial and seasonal allergic rhinitis in young adult women in a population-based cohort study

    DEFF Research Database (Denmark)

    Bendtsen, P; Grønbæk, M; Kjær, S. K.;

    2008-01-01

    Background Alcohol consumption has been suggested to be associated with the development of allergic rhinitis (AR), but there is limited data on the topic. Objectives The objective of this study was to investigate the association between alcohol consumption and the risk of developing AR among young...... associated with the risk of developing seasonal (OR, 2.01; 95% CI, 1.65-2.45) and perennial AR (OR, 2.28; 95% CI, 1.70-2.74). Smoking was not associated with an increased risk of developing AR. Conclusion In this population of young adult women, alcohol consumption was associated with an increased risk...... women. Methods Five thousand eight hundred and seventy Danish women aged 20-29 years participated in a prospective cohort study, and were free of seasonal and perennial AR at baseline (1991-1993). Alcohol consumption was assessed by a food frequency questionnaire. The main outcome measures were self...

  12. [Rhinitis in adults].

    Science.gov (United States)

    Kalogjera, Livije

    2011-01-01

    Rhinitis is a very common disorder caused by inflammation or irritation of nasal mucosa. Dominant symptoms are nasal obstruction; however, in some patients, runny nose, excessive sneezing or nasal itch may be the most bothersome symptoms. The most common causes of nasal inflammation are viral infections and allergic response to airborne allergens. Response to irritants may cause similar symptoms, although signs of inflammation may not always be present. Viral rhinitis is lasting up to 10 days and it is part of the common cold syndrome. In short-lived rhinitis, lasting for 7 to 10 days, sometimes it is not easy to differentiate between the potential causes of the disorder, if general symptoms of infection like fever and malaise are not present. In long-living rhinitis, it is important to differentiate between infectious, allergic, non-allergic non-infectious rhinitis, and chronic rhinosinusitis. Itch and ocular symptoms are more common in allergic rhinitis, while other symptoms like nasal obstruction, rhinorrhea and sneezing may affect patients with allergic and non-allergic rhinitis. Patients with allergic rhinitis often have symptoms after exposure to irritants, temperature and humidity changes, like patients with non-allergic rhinitis, and such exposure may sometimes cause more severe symptoms than exposure to allergens. Sensitivity to a non-specific trigger is usually called non-specific nasal hyperreactivity. Allergic rhinitis occurs due to immunoglobulin E (IgE) interaction with allergen in contact with nasal mucosa in a sensitized patient. Sensitization to certain airborne allergen, like pollens, dust, molds, animal dander, etc. usually occurs in families with allergy background, which is helpful in making diagnosis in patients who have rhinitis in a certain period of the year, or aggravation of nasal symptoms occurs in the environment typical of certain allergen. The diagnosis is clinically confirmed by proving sensitivity to certain allergen on skin prick

  13. Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children

    DEFF Research Database (Denmark)

    Schoos, A-M M; Chawes, B L; Jelding-Dannemand, E;

    2016-01-01

    Prospective Study on Asthma in Childhood2000 birth cohort. Rhinitis was diagnosed at 7 and 13 years. Allergen exposure was defined as dog or cat in the home during the 3rd trimester of pregnancy or the first year of life and as allergen levels of dog, cat, and house dust mite in bed dust samples at 1 year...

  14. 变应性鼻炎大鼠模型的文献研究%Literature Research on Allergic Rhinitis Rat Model

    Institute of Scientific and Technical Information of China (English)

    陈晴; 刘洋; 张勤修

    2015-01-01

    目的:通过对近20年发表变应性大鼠造模的文献进行总结,对国内目前研究现状及动态进行分析,并为如何建立标准化的造模流程及造模后评价提供部分见解。方法:以“变应性鼻炎”和“变应性鼻炎大鼠模型”或“动物实验”为检索词,对中国知网(CNKI)数据库中于1993年8月-2013年10月发表的相关文献进行检索,对文献中描述的造模方式、药物剂量、造模周期、模型评价等进行资料、数据提取后进行归纳及量化分析。结果:本次研究共纳入208篇有效文献,以SD大鼠为造模动物,卵清蛋白+氢氧化铝为致敏剂和佐剂,以腹腔注射+鼻腔激发造模是最常用的造模方式,动物行为学观察量化评分为主要评价指标。结论:目前国内在变应性鼻炎动物造模方面形式多样,造模后评价方式较为单一,建立标准化的变应性鼻炎造模流程及造模后评价亟待所需。%Through summarization on published literatures on allergic rat model in recent 20 years, domestic current research status and trend were analyzed. Some insights were provided on how to build a standard process for modeling and post-modeling evaluation. “Allergic rhinitis,” “rat model of allergic rhinitis”, or “animal experiment” was used as search terms. Related published articles were searched in the CNKI database from August, 1993 to October, 2013. Documents and data, including modeling method, drug dose, modeling cycle, model assessment described in the articles were extracted, summarized and quantitative analyzed. The results showed that 208 valid articles were included in this study. SD rat was used as animal model. Ovalbumin plus aluminum hydroxide were used as adjuvant sensitizing agents. Intraperitoneal injection plus nasal stimulation were the most commonly used modeling method. Behavioral evaluation scale score was used as the main evaluation index. It was concluded

  15. Spectrum of inhalant allergens in allergic rhinitis in Karamay%新疆克拉玛依地区变应性鼻炎患者吸入性变应原分布特征分析

    Institute of Scientific and Technical Information of China (English)

    刘忠云; 关云峰; 陈璇

    2013-01-01

    目的 研究我国新疆克拉玛依地区鼻炎患者的主要吸入性变应原及其分布特征.方法 对新疆克拉玛依地区1000例1~89岁的鼻炎患者进行8种吸入性变应原的皮肤点刺试验,根据患者年龄、合并疾病情况,将患者进行分组并比较分析各组患者的吸入性变应原分布情况以及对多重变应原同时过敏的情况.结果 在本地区的1000例鼻炎患者中,总阳性率为76.7%(767例),最主要的变应原是树木59.1%、黎属47.1%和蒿属44.0%.其中8~18岁患者中同时对多种变应原过敏的比例显著高于其他年龄段的患者(P<0.05);鼻炎合并哮喘的患者中,同时对多种变应原过敏的患者比例显著高于其它患有鼻炎但不合并哮喘的患者(P<0.05).结论 新疆克拉玛依地区变应性鼻炎患者中主要的吸入性变应原是树木、黎属和蒿属.多重过敏可能是该地区鼻炎患者发展成为鼻炎合并哮喘的危险因素之一.%Objective To investigate the major inhalant allergens and the distribution characteristics of that in allergic rhinitis in Karamay Methods Skin prick tests with 8 popular inhalant allergens had been performed in 1000 rhinitis patients aged 1-89 years old. The patients had been divided into several groups according to age or merging diseases, The positive rate, distribution characteristics of allergens and positive reactions to multiple allergens in allergic rhinitis patients had been analyzed and compared between groups. Results Of the 1000 patients, 767 patients (76.7%) had shown positive reaction to at least one allergen. The most popular inhalant allergens in allergic rhinitis were trees (59.1%), Papilionaceae Mucuna(47.1%) and Artemisia(44.0%). Patients aged 8-18 years had been mostly sensitive to multiple allergens and significantly different from other age groups (P<0.05).Similarly, allergic rhinitis with asthma were more sensitive to multiple allergens when compared with allergic rhinitis withuot

  16. Diagnosis and clinical characteristics of patients with non-allergic rhinitis%非变应性鼻炎的诊断及临床特征分析

    Institute of Scientific and Technical Information of China (English)

    王洪田; 张静; 尤少华; 奥彦云; 白银; 石怀银; 籍灵超; 贾婧杰; 张悦

    2014-01-01

    Objective To explore a step-by-step exclusive diagnosis and analyze the clinical characters of non-allergic rhinitis (NAR).Methods Patients with symptoms (nasal itching,sneezing,rhinorrhea,nasal congestion) were selected to take four-step exclusive diagnosis for NAR.The false NAR was eliminated and the true NAR was retained.First step was to exclude the patients who were not suitable for skin prick test (SPT,such as during pregnancy,breastfeeding,asthma,oral antihistamine medication in 7 day,severe skin diseases).The second step was to exclude the patients with positive SPT and the third step was to exclude the patients with 1 level or above of specific seroimmunoglobulin E (sIgE).The fourth step was to exclude the patients with infection rhinitis,clear abnormal nasal structure,drug-induced rhinitis,nasal neoplasm.The remained patients were finally diagnosed as NAR and who were further differential diagnosed as vasomotor rhinitis (VMR) or non-allergic rhinitis with eosinophilia syndrome (NARES) according to the eosinophilia counts in nasal secretion and venous blood.The common characters of patients with NAR were analyzed and their symptoms and quality of life were evaluated by visual analogue scale (VAS) and rhino-conjunctivitis quality of life questionnaire (RQLQ) separately.Results One thousand four hundred and thirty-seven patients were included after first step exclusion and 735 cases with negative SPT were remained after second step exclusion.Of 735 patients,302 were tested in vitro for sIgE and 93 cases with 0 level of sIgE and total IgE were remained after third step exclusion.Sixty-two patients were finally diagnosed as NAR after fourth step exclusion.The NAR diagnosis rate was 51.15% (735/1 437) with negative SPT alone and the NAR diagnosis rate was 29.06% (93/302) with combination of negative SPT and sIgE.Of 62 patients with NAR,47 patients (75.81%) were diagnosed as VMR and 15 cases (24.19%) as NARES.There were 23 males and 39 females in the 62

  17. A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

    Science.gov (United States)

    Aryan, Zahra; Holgate, Stephen T; Radzioch, Danuta; Rezaei, Nima

    2014-01-01

    Toll-like receptors (TLR) belong to a large family of pattern recognition receptors known as the ancient 'gatekeepers' of the immune system. TLRs are located at the first line of defense against invading pathogens as well as aeroallergens, making them interesting targets to modulate the natural history of respiratory allergy. Agonists of TLRs have been widely employed in therapeutic or prophylactic preparations useful for asthma/allergic rhinitis (AR) patients. MPL® (a TLR4 agonist) and the CpG oligodeoxynucleotide of 1018 ISS, a TLR9 agonist, show strong immunogenicity effects that make them appropriate adjuvants for allergy vaccines. Targeting the TLRs can enhance the efficacy of specific allergen immunotherapy, currently the only available 'curative' treatment for respiratory allergies. In addition, intranasal administration of AZD8848 (a TLR7 agonist) and VTX-1463 (a TLR8 agonist) as stand-alone therapeutics have revealed efficacy in the relief of the symptoms of AR patients. No anaphylaxis has been so far reported with such compounds targeting TLRs, with the most common adverse effects being transient and local irritation (e.g. redness, swelling and pruritus). Many other compounds that target TLRs have been found to suppress airway inflammation, eosinophilia and airway hyper-responsiveness in various animal models of allergic inflammation. Indeed, in the future a wide variability of TLR agonists and even antagonists that exhibit anti-asthma/AR effects are likely to emerge.

  18. Sensitization to Aeroallergens in Children with Allergic Rhinitis%儿童过敏性鼻炎的吸入性过敏原

    Institute of Scientific and Technical Information of China (English)

    张媛; 赵延明; 贺飞; 张罗

    2011-01-01

    目的 调查北京地区过敏性鼻炎儿童的主要吸入性过敏原.方法 采用21种标准化过敏原对北京地区458例3~18岁的过敏性鼻炎儿童进行皮肤点刺试验,描述过敏原的整体分布特征,并依据性别和年龄进行分层分析.比较不同年龄组在过敏原阳性率分布上的差异.结果 过敏原皮肤点刺实验阳性率前10位的过敏原分别为屋尘螨(83.6%)、粉尘螨(83.2%)、动物毛(15.7%)、大豚草(13.3%)、树1(13.3%)、藜(13.1%)、树2(12.0%)、交链孢霉属(9.6%)、刺槐(9.2%)和禾本科(9.2%).尘螨在男性和女性儿童中均为最常见过敏原.在377例尘螨过敏患儿中,强阳性者占87.0%.分别以阳性率最高点14岁以及强阳性率最高点11岁为界进行分组,尘螨过敏的强阳性率在组间差异均无统计学意义(P>0.05).结论 尘螨是北京地区儿童过敏性鼻炎最重要的过敏原.%Objective To investigate which aeroallergens were prevalent in children with allergic rhinitis in Beijing region.Methods A total of 458 cases(aged from 3 to 18 years) who were diagnosed with allergic rhinitis, underwent a skin prick test with 21 standardized aeroallergeus, and the important sensitizing allergens were assessed.The stratified analysis for gender and age were also performed.Differences in SPT responses among the groups according to age were explored.Results The percent of patients with positive skin tests were as follows: Dermatophagoides pteronyssinus ( 83.6% ), Dermatophagoides farinae ( 83.2% ), animal hair ( 15.7% ), giant ragweed( 13.3% ), Tree Ⅰ ( 13.3% ), Chenopodium album( 13.1% ), Tree Ⅱ ( 12.0% ), Alternaria alternate(9.6% ), Locust(9.2% )and Gramineae(9.2% ).The dust mite was the most popular allergen regardless of gender.The individuals who showed strong positive response to dust mite accounted for 87.0% among the 377 dust mite allergic subjects.There was no significantly higher sensitivity to dust mite among groups

  19. Minnesota multiphasic personality inventory of patients with allergic rhinitis%变应性鼻炎患者心理人格特征研究

    Institute of Scientific and Technical Information of China (English)

    锡琳; 张伟; 赵岩; 张罗

    2011-01-01

    Objective To explore the relationship between allergic rhinitis(AR) and personality traits in nonpsychiatric population of allergic status. Methods Subjects were assigned to the allergic (84 cases) or nonallergic health group (37 cases) on the basis of skin prick test (SPT) and allergic symptoms. The psychological aspects of subjects were assessed by using the minnesota muliphasic personality inventory (MMPI). Results The allergic group scored higher than the nonallergic group on five clinical scales, hypochondriasis ( Hs ), depression ( D), hysteria ( Hy ), hypomania ( Ma ), social introversion ( Si ), and one research scale manifest aniety scale (Mas). The differences were significant ( t value was respectively 2. 169, 2.711, 2.010, 2.577, 2.390 and 2. 196, all P <0.05). In addition, the grade of resultant skin wheal was positively correlated with T scores on the Hs, Hy, psychopathic deviance (Pd) and psychasthenia ( Pt ). The r value was 0. 366, 0. 449, 0. 345 and 0. 355 respectively ( all P < 0. 05 ).Conclusion Subjects with AR show poorer psychological functioning, indicating the close relationship between AR and psychological status.%目的 探讨变应性鼻炎(allergic rhinitis,AR)患者的基本心理人格特征.方法 应用明尼苏达多相个性调查表(minnesota muliphasic personality inventory,MMPI)分析84例AR患者和37例健康对照者的心理人格特征.结果 AR患者在疑病量表(hypochondriasis,Hs)、抑郁量表(depression,D)、癔病量表(hysteria,Hy)、轻躁狂量表(hypomania,Ma)、社会内向量表(social introversion,Si)5个临床量表T分和外显焦虑量表(manifest aniety scale,Mas)T分明显高于健康对照(t值分别为2.169、2.711、2.010、2.577、2.390、2.196,P值均<0.05).皮肤点刺风团等级与Hs、Hy、精神病态量表(psychopathic deviance,Pd)、精神衰弱量表(psychasthenia,Pt)的T分呈正相关(r值分别为0.366、0.449、0.345、0.355,P值均<0.05),风团直径越大患者Hs、Hy、Pd

  20. Increase in the prevalence of rhinitis among Danish children from 1986 to 2001

    DEFF Research Database (Denmark)

    Håkansson, K; Thomsen, SF; Ulrik, Charlotte Suppli;

    2007-01-01

    .001). The increase was most pronounced among subjects who suffered from non-allergic rhinitis (p history of asthma and parental atopic disease were...... strong predictors of non-allergic rhinitis, whereas a history of asthma, parental atopic disease, bronchial hyperresponsiveness, eczema, and age at examination were statistically significant predictors of allergic rhinitis. The prevalence of non-allergic rhinitis among Danish children has increased...

  1. 捏脊配合针刺在瑞士治疗过敏性鼻炎58例%Fifty-eight cases of allergic rhinitis treated with chiropractic and acupuncture in Switzerland

    Institute of Scientific and Technical Information of China (English)

    高军; 韩景献; ZHANG Yi

    2010-01-01

    @@ Allergic rhinitis (AR) pertains to anaphylaxis in biomedicine while to the domain of "Bigiu"(鼻鼽)in Chinese medicine with the main symptoms of rhinocnesmus, sneezing, thin nasal discharge and nasal obstruction.The disease is often persistent with high ratio of recurrent attacks.Specific medicine or methods for the radical treatment are still not available.However, great progress on treatment of AR with acupuncture has been made in recent 10 years.

  2. La estria supranuclear de las células ciliadas en la rinitis alérgica Supranuclear stria of ciliated cells in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Ana Zerdiew

    2007-08-01

    Full Text Available Se estudiaron 80 pacientes adultos alérgicos, que cursaron con los siguientes cuadros clínicos: 16 casos de rinitis intermitente y 64 de rinitis persistente. Se realizó el recuento porcentual de la estría supranuclear de las células ciliadas, respecto de los leucocitos presentes en los extendidos obtenidos por toma endonasal. Con los datos obtenidos se clasificaron los extendidos en 4 grupos; Grupo A (N=23: predominio leucocitario eosinófilo con eosinofilia nasal >10%, Grupo B (N=15: abundantes leucocitos neutrófilos y eosinofilia nasal >10%, Grupo C (N=29: con escasos leucocitos, Grupo D (N=13: con abundantes leucocitos de predominio neutrófilo sin eosinofilia. Se observó que el incremento porcentual de estría supranuclear se correlacionó con eosinofilia nasal >10% y con las muestras que presentaron escasos leucocitos. Sin embargo se evidenció una marcada disminución del porcentaje de estría supranuclear en la leucocitosis neutrófila de etiología bacteriana.Nasal secretions were studied in 80 allergic adults patients: 16 with intermittent rhinitis and 64 with persistent rhinitis. The percentage of supranuclear stria of ciliated cells with regard to leucocytes was studied by nasal scraping. Four groups of patients were classified according to nasal leucocytic predominance: patients with eosinophilic predominance with eosinophils > 10% in Group A (N=23, patients with abundant neutrophils and eosinophils >10% in Group B (N=15, patients with scant leucocytes in Group C (N=29, patients with neutrophilic predominance without eosinophils in Group D (N=13. An increase of supranuclear stria percentage was correlated to eosinophils > 10% and also correlated to scant leucocytes. Nevertheless, a significant decrease of supranuclear stria percentage was observed in neutrophilic leukocytosis of bacterial etiology.

  3. OBSERVATION OF REMOTE AND RECENT THERAPEUTIC EFFECTS OF ACUPOINT-THREAD EMBEDDING, WESTERN MEDICINE OR ALLIED THERAPY ON PERENNIAL ALLERGIC RHINITIS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-ping; CHEN Li-yi; LUO Rui-lian; GUO Yuan-qi; WU Wen-yi

    2006-01-01

    Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine + fl ixonase) and allied therapy. Method: Ninety cases were randomized into thread-embedding group, western medicine group and embedding+ western medicine group (allied-therapy group), 30 cases in each one.In thread embedding group, Yingxiang (迎香 LI 20) and Feishu (肺俞 BL 13) were selected for thread embedding, once a week, totally 4 treatments were required. In western medicine group, certirizine tablet 10 mg in combination with fl ixonase sprayer was applied once per day, continuously for 30 days in treatment.In allied-therapy group, both of the above methods were adopted continuously for 30 days in treatment. The therapeutic effects were in statistics at the end of treatment and 1 year later. Results: At the end of treatment, in thread-embedding group, 21 cases were remarkably effective, 3 cases effective and 6 cases no effect. In western medicine group, 20 cases were remarkably effective, 3 cases effective and 7 cases no effect. In allied-therapy group, 23 cases were remarkably effective, 2 cases effective and 5 cases no effect. It was shown in statistics that there was no significant difference in therapeutic effects among three groups (P>0.05). But one year after the end of treatment, it was indicated that in thread-embedding group, 3 cases were remarkably effective, 10 cases effective and 17 cases no effect; in western medicine group, 2 cases were remarkably effective, 9 cases effective and 19 cases no effect; in allied-therapy group, 7 cases were remarkably effective, 11 cases effective and 12 cases no effect. The significant difference in the therapeutic effects had not been presented in the comparison between thread-embedding group and western medicine group (P>0.05), but that had been presented between allied-therapy group with either of the

  4. [Preparation of human soluble FcepsilonR1α and detection of serum FcepsilonR1α antibodies in patients with allergic rhinitis].

    Science.gov (United States)

    Xing, Huihui; Shao, Hui; Cao, Xiuqin; Yang, Zhiwei

    2016-05-01

    Objective To induce the expression of human soluble Fc epsilon receptor I alpha (sFcepsilonR1α) in a prokaryotic expression vector, purify the recombinant human sFcepsilonR1α protein, detect its binding affinity for human serum IgE antibodies and detect the levels of sFcepsilonR1α, sFcepsilonR1α-IgE and FcepsilonR1α antibodies. Methods The FcepsilonR1α extracellular region gene was amplified using nested polymerase chain reaction (PCR) and was expressed in a prokaryotic expression vector pET-sFcepsilonR1α using recombinant DNA technology under optimal conditions. The human sFcepsilonR1α protein was purified using iminodiacetic acid (IDA) His binding resin and identified using Western blotting. The affinity between the recombinant human sFcepsilonR1α and serum IgE antibodies and the levels of total sFcepsilonR1α, sFcepsilonR1α-IgE and FcepsilonR1α antibodies were measured using ELISA. Results The amplified gene corresponding to the extracellular region FcepsilonR1α was approximately 600 bp. PCR, double enzyme digestion and sequencing confirmed the correct sequence of the expression vector pET-sFcepsilonR1α. After human sFcepsilonR1α protein was induced in the expression vector pET-FcepsilonR1α and purified, Western blotting showed that its relative molecular mass (Mr) was approximately 42 000. ELISA revealed that the human sFcepsilonR1α bound with a high affinity to serum IgE, and the lower levels of total sFcepsilonR1α and sFcepsilonR1α-IgE and higher levels of serum anti-FcepsilonR1α antibodies in the patients with allergic rhinitis than in the normal subjects. Conclusion We successfully synthesized human sFcepsilonR1α which had a strong binding affinity for human serum IgE. The higher levels of serum anti-FcepsilonR1α antibodies in the patients with allergic rhinitis than the normal subjects. PMID:27126944

  5. Gellan co-polysaccharide micellar solution of budesonide for allergic anti-rhinitis: an in vitro appraisal.

    Science.gov (United States)

    Maiti, Sabyasachi; Chakravorty, Amrita; Chowdhury, Moumita

    2014-07-01

    The aim of this study was to design a novel amphiphilic co-polysaccharide for the development of anti-rhinitis micellar solution of budesonide. Herein, a long alkyl chain (C18) was successfully grafted onto gellan polysaccharide by etherification reaction. The dispersion of co-polysaccharide in water led to formation of spherical, nanomicellar structures. Depending upon the co-polysaccharide:drug weight ratio (1:1, 1:2 and 1:3), a maximum drug loading (>95%) was noted at the lowest level. The nanomicelles were in the range of 371-750nm and showed negative zeta potential (-48.3 to -67.2mV) values indicating their stability in aqueous system. They exhibited a longer dissolution profile in simulated nasal fluid (pH 5.5). The dissolution efficiency (39.79±0.93%) was maximal at the lowest polymer: drug ratio in 6h. The drug release was found to follow first order kinetic model. Korsmeyer-peppas modeling of in vitro drug release data indicated that besides simple diffusion, no other physical phenomenon was involved in the event of drug release from the nanostructures. Differential scanning calorimetry analysis suggested some degree of physical incompatibility; however Infrared spectroscopy revealed chemical compatibility between drug and co-polysaccharide. Thus, the co-polysaccharide micellar system offers a splendid outlook in controlled intranasal delivery of budesonide for the symptomatic relief of anti-rhinitis. PMID:24820153

  6. Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial

    DEFF Research Database (Denmark)

    Bager, Peter; Arnved, John; Rønborg, Steen;

    2010-01-01

    Parasitic helminth infections can protect against allergic airway inflammation in experimental models and have been associated with a reduced risk of atopy and a reduced course of asthma in some observational studies. Although no clinical evidence exists to support the use of helminth therapy for...

  7. Genetics Home Reference: allergic asthma

    Science.gov (United States)

    ... another allergic disorder, such as hay fever (allergic rhinitis) or food allergies. Asthma is sometimes part of ... the Symptoms of an Allergy? Centers for Disease Control and Prevention Disease InfoSearch: Asthma Johns Hopkins Medicine: ...

  8. Prevalence of sensitivity to cockroach allergens and IgE crossreactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma

    Institute of Scientific and Technical Information of China (English)

    SUN Bao-qing; LAI Xu-xin; Birgitte Gjesing; Michael Dho Spangfort; ZHONG Nan-shan

    2010-01-01

    Background Cockroaches are an important indoor allergen source causing allergic rhinitis and asthma. The aim of this study was to investigate the cockroach prevalence in mainland of China and the cross-reactivity of IgE between cockroach and house dust mite allergen in Chinese patients.Methods The cockroach sensitization pattern was based on a skin prick test (SPT) obtained from a national multicenter prevalence study, in which 6304 patients from 25 allergy centers across China participated. Factors, including different regions of China, age, gender and the correlations between the American and German cockroaches and house dust mite Der p were investigated. Eighteen out of 1236 clinical sera from south China were selected to perform the cross-inhibition assay between house dust mites and cockroaches.Results Totally 25.7% of patients were SPT positive to the American cockroach (Periplaneta Americana, Per a) and 18.7% SPT positive to the German cockroach (Blattella germanica, Bla g). The prevalence of positive cockroach SPT was higher in southern than in northern China, higher in adults than in children, and higher in males than in females.Patients had relatively low levels of cockroach SPT reactions, mainly class 1 or 2. Of the SPT positive cockroach patients,88% were also SPT positive to house dust mite (Dermatophagoides pteronyssinus, Der p). An IgE cross-inhibition study confirmed that Der P sensitization could cause false positive SPT reactions against cockroach.Conclusions A relatively high prevalence of cockroach sensitivity was found in mainland of China. However, a cross-inhibition study showed that only a small number of patients appear to have Bla g and/or Per a as primary sensitizing source. The importance of cockroaches as a risk factor for sensitization and triggers of allergic symptoms in mainland of China needs to be further investigated.

  9. Allergen and risk factors of allergic rhinitis patients in Hainan area%海南地区部分变应性鼻炎患者变应原检测及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    李剑挥; 袁永一; 王新; 雷磊

    2015-01-01

    Objective To analyze the distribution of allergens in patients with allergic rhinitis and related risk factors in Hainan area. Methods IgE and allergen specific IgE antibody in 196 patients with allergic rhinitis and 68 cases of controls admitted to Hainan branch of Chinese PLA General Hospital from October 2013 to October 2014 were collected and tested by Western Blot. Questionnaire survey was conducted in 196 cases and 204 controls, then multi-factor logistic regression analysis was used to investigate 12 possible related factors of allergic rhinitis. Results The total IgE of 196 allergic rhinitis patients were all positive, in which, the allergen specific IgE antibody of dust mites showed the highest positive rate (59.69%), and fish was the main allergens (positive rate 17.35%), while in 68 cases of controls, only 2 cases showed positive allergens (fish). Family history, history of allergies and asthma were main risk factors for allergic rhinitis. Keeping windows open and rooms clean were protective factors for allergic rhinitis. Conclusion In Hainan area, the main allergens of allergic rhinitis is house dust mites with risk factors including family history, history of allergies, etc. Patients show a trend of younger age, while it has nothing to do with the season.%目的:分析海南地区变应性鼻炎患者变应原分布情况及相关危险因素。方法用免疫印迹法对2013年10月-2014年10月于解放军总医院海南分院耳鼻咽喉科门诊就诊的196例变应性鼻炎患者及68例对照者血清总IgE和变应原特异性IgE抗体进行检测,并对196例患者及204例对照者进行问卷调查,用多因素Logistic回归分析问卷调查12项变应性鼻炎的可能影响因素。结果196例变应性鼻炎患者血清总IgE均为阳性,变应原特异性IgE抗体以尘螨的阳性率(59.69%)最高,食入性变应原以海鱼为主(阳性率17.35%),68例对照者仅2例检测出阳性变应原(海鱼)。家族史、过敏史

  10. Análise de citocinas pela RT-PCR em pacientes com rinite alérgica RT-PCR cytokine study in patients with allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Tarcimara Moreira da Silva

    2009-02-01

    Full Text Available Rinite alérgica é uma doença que decorre de um processo inflamatório da mucosa nasal conseqüente à reação de hipersensibilidade a alérgenos inalatórios e, eventualmente, alimentares. É mediada por IgE, envolvendo diferentes células, mediadores e citocinas. OBJETIVO: Avaliar as transcrições para as seguintes citocinas: IL-4, IL-5, IL-8 e IFN-gama, particularmente importantes no processo alérgico nasal, principalmente IL-4 e IL-5. Neste estudo, optou-se por avaliar os pacientes atópicos fora das crises alérgicas, com a finalidade de se conhecer as expressões das citocinas neste período. MATERIAL E MÉTODO: Realizou-se um estudo transversal e prospectivo, selecionando-se 30 pacientes, sendo 13 pacientes portadores de rinite alérgica paucissintomáticos e 17 pacientes não-atópicos. Os grupos foram selecionados através da história, do exame clínico otorrinolaringológico e do teste alérgico cutâneo - Prick Test. O perfil das citocinas foi pesquisado nos fragmentos de mucosa nasal, através da RT-PCR semiquantitativa, escolhida por apresentar boa reprodutibilidade e especificidade, utilizando-se como referência o gene da Beta-actina. RESULTADOS: Os valores de IL-5, IL-8, IFN-gama mantiveram-se homogêneos em relação ao grupo controle. A IL-4 apresentou diferença com significância estatística. CONCLUSÃO: Os pacientes alérgicos paucissintomáticos apresentaram normalização da expressão das citocinas na mucosa nasal à exceção de IL-4.Allergic rhinitis is an inflammatory reaction of the nasal mucosa, in consequence of an IgE mediated hypersensitive reaction to inhaling allergens, involving different mediators and cytokine cells. AIM: The purpose of this study was to evaluate the transcriptions for IL-4, IL-5, IL-8 and IFN-gama, particularly important in the nasal allergy process, especially IL-4 and IL-5. For this study we decided to evaluate atopic patients who were free from allergic crises, with the purpose of

  11. 南阳市慢性过敏性鼻炎患者过敏原检测结果分析%Analysis of Allergen Detection Results in Patients With Chronic Allergic Rhinitis in Nanyang City

    Institute of Scientific and Technical Information of China (English)

    宋彬

    2015-01-01

    Objective To understand the types and distribution of allergens in patients with chronic allergic rhinitis in nanyang, and to provide reliable evidence for the prevention and treatment of this disease.Methods ELISA method was used for the determination of serum total IgE and specific IgE in patients with chronic allergic rhinitis, and the comparative analysis was carried out.Results Patients with chronic allergic rhinitis in total IgE positive rate of 100%, the 2 cases of specific allergen test negative, specific allergen detection results for dermatophagoides pteronyssinus 113 cases of the positive (37.7%), house dust was positive in 90 cases (30.0%), trees (oak, elm, sycamore, willow, cottonwood yang) was positive in 54 cases (18.0%). Conclusion Nanyang city cause chronic allergic rhinitis allergic principle mainly in household dust mites, house dust, trees (oak, elm, sycamore, willow, cottonwood yang).%目的 了解南阳市慢性过敏性鼻炎患者过敏原的种类及分布,为本病预防和治疗提供可靠依据.方法 采用ELISA法对慢性过敏性鼻炎患者的血清总IgE和特异性IgE进行半定量测定,并进行对比分析.结果 慢性过敏性鼻炎患者中总IgE阳性率100%,其中2例特异性过敏原检测阴性,特异性过敏原检测结果 为:户尘螨阳性113例(37.7%),屋尘阳性90例(30.0%),树木(栎树、榆树、梧桐、柳树、三角叶杨)阳性54例(18.0%).结论 南阳市引起慢性过敏性鼻炎的过敏原主要是户尘螨,屋尘,树木(栎树、榆树、梧桐、柳树、三角叶杨).

  12. 咪唑斯汀治疗荨麻疹并发过敏性鼻炎的疗效和安全性观察%Therapeutic effect and safety of mizolastine in the treatment of urticaria and allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    朱宇

    2012-01-01

    目的:观察咪唑斯汀(皿治林)治疗急慢性荨麻疹并发过敏性鼻炎的临床疗效及安全性.方法:选取我院2007年3月-2010年4月收治的120例急、慢性荨麻疹并发过敏性鼻炎患者,随机分为试验组(咪唑斯汀组)和对照组(西替利嗪组)各60例,比较两组患者的治疗效果及不良反应情况.结果:①试验组在用药1h内起效效果明显优于对照组.②试验组总有效率为88.3%,对照组总有效率为76.7%,两组患者总有效率比较差异有统计学意义.急性荨麻疹并发过敏性鼻炎患者中,试验组与对照组差异无统计学意义;慢性荨麻疹并发过敏性鼻炎患者中,试验组与对照组差异有统计学意义.③试验组患者出现轻微口干2例,对照组出现头痛1例,嗜睡3例,口干2例.两组患者不良反应比较差异有统计学意义(P<0.05).④试验组患者的满意度明显高于对照组.结论:咪唑斯汀(皿治林)治疗急慢性荨麻疹并发过敏性鼻炎的效果理想,且不良反应轻微,不嗜睡,临床用药安全性较高.%Objective: To observe the therapeutic effect and safety of mizolastine in the treatment of acute /chronic urticaria with allergic rhinitis. Method: One hundred and twenty cases of acute /chronic urticaria with allergic rhinitis were recruited in our hospital from March 2007 to April 2010, and randomly divided them into observation group (mizolastine treatment group) and control group (cetirizine group), each group consisted of 60 cases. The therapeutic effect and adverse reactions of these two groups were compared. Results: ①The therapeutic effect of the observation group within one hour of treatment was evi dently better than that of the control group. ②The total effective rate of the observation group was 88.3%, and the control group 76.7%. There was a significant difference between the total effective rates of the two groups. There was no a significant difference between the total effective rates of

  13. The efficacy of Rhinos® SR on nasal resistance and nasal symptoms in patients with perennial allergic rhinitis : a randomized, double-blind, placebo-controlled study

    Directory of Open Access Journals (Sweden)

    Arini Setiawati

    2008-06-01

    Full Text Available Rhinos® SR is a fixed combination of 5 mg loratadine and 60 mg pseudoephedrine immediate release and 60 mg pseudoephedrine sustained release. The present study was aimed to assess the efficacy of Rhinos® SR on nasal airway resistance (NAR objectively using rhinomanometer and on nasal symptoms in patients with perennial allergic rhinitis (PAR in a tropical country. This was a randomized, double-blind, parallel group study in 59 PAR patients who visited the ENT clinic at Dr. Soetomo General Hospital, Surabaya. Outpatients of both gender, having moderate to severe PAR for a minimal of 2 years, aged 12 years or older, with a total nasal symptom score (TNSS > 6 and a nasal congestion score > 2, received Rhinos® SR or placebo twice daily for 7 days. The primary efficacy parameter was the decrease in the NAR values (measured by rhinomanometer on Day 1 of Rhinos® SR from those of placebo. The NAR values were calculated as the area under the curve (AUC of NAR versus time. The secondary efficacy parameters were the percentage reduction of the clinical symptoms (nasal and nonnasal evaluated by both the patient and the physician after 1 week use of Rhinos® SR or placebo. From 59 eligible patients, all completed this 1-week trial. For NAR values, after the baseline were considered as 100%, the AUC0-10 h were not significantly different between Rhinos® SR and placebo. However, as the pseudoephedrine reached its peak concentration, i.e. 2 hrs for the immediate release and 6 hrs for the sustained release, then AUC0-2 h and AUC0-6 h of Rhinos® SR were significantly lower compared to those of placebo. Total nasal symptom score (TNSS evaluated by the patient (sum of the last 3 mornings for Rhinos® SR decreased 33.0% from baseline (p < 0.001, for placebo decreased 21.9% from baseline (p = 0.002, but the decrease by Rhinos® SR was not significantly different from the decrease by placebo. TNSS evaluated by the physician, nasal congestion score (NCS and total

  14. Therapeutic Effect of Beehive Extract for Treatment of Allergic Rhinitis%蜂巢提取物治疗变应性鼻炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    张凤姣; 李维榕; 罗岳雄; 赵红霞; 李万瑶

    2015-01-01

    [目的] 观察蜂巢提取物对变应性鼻炎患者的临床疗效. [方法] 将符合纳入标准的60例受试者, 随机分为大剂量组和小剂量组各30例. 大剂量组给予口服蜂巢提取物15 g/次, 3次/ d; 小剂量组给予口服蜂巢提取物5 g/次, 3次/ d; 服用1周为1个疗程, 2组均服用4个疗程后观察疗效, 并于停服1个月时随访. [结果] (1) 大剂量组总有效率为90.00%,小剂量组为93.00%, 2组比较 (秩和检验), 差异无统计学意义 (P>0.05). (2) 治疗后及随访时, 2组患者总症状视觉模拟评分量表 (Uni-VAS)、 鼻结膜炎生活质量量表 (RQLQ) 各维度评分均显著降低 (P0.05). [结论] 口服大剂量和小剂量蜂巢提取物均能显著改善变应性鼻炎患者的症状, 两者总体疗效相当, 但随访时小剂量组在症状量表评分方面有回升 (即复发) 的趋势.%Objective To observe the therapeutic effect of beehive extract for the treatment of allergic rhinitis. Methods Sixty qualified subjects were evenly randomized into large dose group and small dose group, 30 in each group. The large dose group was given oral use of beehive extract 15 g per time, and the small dose group was given 5 g per time, three times per day. One week constituted a treatment period, and the treatment lasted 4 courses. After treatment, the therapeutic effect was evaluated in both groups. Follow-up was carried out one month after suspension of medicine. Results ( 1) The total effective rate was 90.00% in the large dose group, and was 93.00% in the small dose group, and the rank sum test results showed the difference was insignificant between the two groups (P>0.05) . (2) After treatment and during follow-up, the scores of general symptom Visual Analog Scale ( Uni-VAS) and the scores of Rhinoconjunctivitis Quality of Life Questionnaire ( RQLQ) were decreased in both groups ( P0.05) . Conclusion Oral use of large or small dose of beehive extract shows certain therapeutic effect for

  15. Common aeroallergens in patients with asthma and allergic rhinitis living in southwestern part of iran: based on skin prick test reactivity.

    Directory of Open Access Journals (Sweden)

    Shokrollah Farrokhi

    2015-04-01

    Full Text Available Aeroallergens continue to have a key role in the pathogenesis of asthma and allergic diseases and have recently received increased attention in medical research throughout the world. The prevalence of aeroallergens vary in different regions, depending on the type of climate. The aim of the present study was to determine prevalence of the sensitivity to aeroallergens among patients with asthma and allergic rhinitis (AR, based on skin prick test (SPT reactivity in the province of Bushehr, Iran. In this cross-sectional study, 743 patients were enrolled. The participants had asthma and AR and reacted to at least one allergen with SPT. Skin prick test with standard extracts including house dust mites (HDMs, animal dander, molds and pollens were performed on patients according to the herbal geography of the area. The male to female ratio and mean age of the patients were 1.03 and 27.6± 15.4 year, respectively. Out of 567 patients with AR, the common aeroallergens were HDMs (88.5%, molds (82.9%, animal dander (79.5%, weeds (77.6%, trees (75.5% and grass pollen (71.5%. Moreover, among 176 patients with asthma, the prevalence of aeroallergens were HDMs (90.5 %, molds (80.7%, animal dander (77.5%, weeds (73.3%, trees (73.3% and grass pollen (67.9%. The sensitivity to animal dander, Chenopodium album and Russian thistle pollens were significantly associated with the severity of AR. Moreover, sensitivity to animal dander such as cat and feather of birds, cockroach, Bermuda grass and Chenopodium album pollens were significantly associated with the severity of asthma. The results of this study revealed that HDM was the most common sensitizing aeroallergen in patients with asthma and AR. Molds and animal dander as indoor allergens were also common aeroallergens. We suggest that the hot weather and ambient humidity in the region may be the main cause of the change in the pattern of SPT reactivity.

  16. Effect of Treatment with Intranasal Corticosteroid and Oral Antihistamine on Cytokine Profiles of Peripheral Blood Mononuclear Cells of Patients with Allergic Rhinitis Sensitive to Chenopodium album

    Directory of Open Access Journals (Sweden)

    Shokrollah Farrokhi

    2010-12-01

    Full Text Available Patients with allergic rhinitis (AR show increased production of the Th2-related cytokines. Almost always, intranasal corticosteroid (INC and antihistamine are used as routine therapy of AR. This study was performed to determine the in vitro secretion of cytokines profiles of PBMCs in patients with AR sensitive to Chenopodium album (Ch.a pollens before and after treatment with INC (Fluticasone propionate and oral antihistamine (Loratadine. PBMCs of 20 patients with AR, were tested in vitro for cytokine production. These cells were stimulated with natural or recombinant Ch.a. The levels of IL-4, IL-13 and IFN-, were measured in supernatants of cultured cell 96h after stimulation using ELISA. The PBMCs of 20 normal individuals were also similarly treared for comparison of results. The production of IL-4 by the patients' cells stimulated with either Ch.a or rCh.a was significantly higher than normal levels before therapy (p=0.04 and p=0.02, respectively. After therapy, a significant decrease in production of IL-4 and a significant increase in production of IL-10 were found in PBMCs stimulated with natural Ch.a, in comparison to the results before stimulation (p=0.03 for IL-4; p=0.04 for IL-10. Similarly, these results were seen in the production of IL-4 and IL-10 stimulated with rCh.a allergen after therapy in comparison to the results before stimulation (p=0.01 for IL-4; p=0.03 for IL-10. This study suggests INC (Fluticasone propionate and oral antihistamine (Loratadine have the capacity to inhibit the production of IL-4 and shift Th2/Th1 responses, probably due to increase the level of immunoregulatory IL-10. Therefore, it could be concluded that therapy with INC and antihistamine has pharmacologic and immunologic therapeutic effects on AR patients.

  17. An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients.

    Science.gov (United States)

    Wei, Ping; Hu, Guo-Hua; Kang, Hou-Yong; Yao, Hong-Bing; Kou, Wei; Liu, Hong; Zhang, Cheng; Hong, Su-Ling

    2014-05-01

    A predominant Th17 population is a marker of allergic rhinitis (AR). The aryl hydrocarbon receptor (AhR) exhibits strong immunomodulation potential via regulation of the differentiation of T lymphocytes and dendritic cells (DCs) after activation by its ligand, such as 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). The aim of this study was to analyze the effect of AhR on Th17 differentiation by investigating the action of ITE on DCs and CD4(+) T cells from patients with AR. In all, 26 AR patients and 12 healthy controls were included in this study. The expression of interleukin (IL)-1β, IL-6, IL-10, and IL-17 in the culture supernatant and the presence of Th17 cells in CD4(+) T cells and DC-CD4(+) T-cell co-culture system were measured before and after treatment with ITE. We show that ITE significantly induced cell secretion of IL-10 and inhibited IL-1β and IL-6 production in DCs, and promoted IL-10 production and suppressed IL-17 expression in CD4(+) T cells in vitro. It also suppressed the expansion of Th17 cells in vitro. Our work demonstrates that ITE acts on DCs and CD4(+) T cells to inhibit the Th17 response that suppresses AR; the AhR-DC-Th17 axis may be an important pathway in the treatment of AR. ITE, a nontoxic AhR ligand, attenuated the Th17 response; thus, it appears to be a promising therapeutic candidate for suppressing the inflammatory responses associated with AR.

  18. Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

    Science.gov (United States)

    Phan, Hanna; Moeller, Matthew L; Nahata, Milap C

    2009-01-01

    Allergic rhinitis (AR) affects a large percentage of paediatric patients. With the wide array of available agents, it has become a challenge to choose the most appropriate treatment for patients. Second-generation antihistamines have become increasingly popular because of their comparable efficacy and lower incidence of adverse effects relative to their first-generation counterparts, and the safety and efficacy of this drug class are established in the adult population. Data on the use of the second-generation antihistamines oral cetirizine, levocetirizine, loratadine, desloratadine and fexofenadine, and the leukotriene receptor antagonist montelukast as well as azelastine nasal spray in infants and children are evaluated in this review. These agents have been found to be relatively safe and effective in reducing symptoms associated with AR in children. Alternative dosage forms such as liquids or oral disintegrating tablets are available for most agents, allowing ease of administration to most young children and infants; however, limited data are available regarding use in infants for most agents, except desloratadine, cetirizine and montelukast. Unlike their predecessors, such as astemizole and terfenadine, the newer second-generation antihistamines and montelukast appear to be well tolerated, with absence of cardiotoxicities. Comparative studies are limited to cetirizine versus ketotifen, oxatomide and/or montelukast. Although second-generation antihistamines and montelukast are deemed relatively safe for use in paediatric patients, there are some noteworthy drug interactions to consider when selecting an agent. Given the wide variety of available agents for treatment of AR in paediatric patients, the safety and efficacy data available for specific age groups, type of AR, dosage form availability and cost should be considered when selecting treatment for AR in infants and children. PMID:19943707

  19. Does the duration and time of sleep increase the risk of allergic rhinitis? Results of the 6-year nationwide Korea youth risk behavior web-based survey.

    Directory of Open Access Journals (Sweden)

    Jeoung A Kwon

    Full Text Available Allergic rhinitis (AR is the most common chronic disorder in the pediatric population. Although several studies have investigated the correlation between AR and sleep-related issues, the association between the duration and time of sleep and AR has not been analyzed in long-term national data. This study investigated the relationship between sleep time and duration and AR risk in middle- and high-school students (adolescents aged 12-18. We analyzed national data from the Korea Youth Risk Behavior Web-based Survey by the Korea Centers for Disease Control and Prevention from 2007-2012. The sample size was 274,480, with an average response rate of 96.2%. Multivariate logistic regression analyses were conducted to determine the relationship between sleep and AR risk. Furthermore, to determine the best-fitted model among independent variables such as sleep duration, sleep time, and the combination of sleep duration and sleep time, we used Akaike Information Criteria (AIC to compare models. A total of 43,337 boys and 41,665 girls reported a diagnosis of AR at baseline. The odds ratio increased with age and with higher education and economic status of the parents. Further, students in mid-sized and large cities had stronger relationships to AR than those in small cities. In both genders, AR was associated with depression and suicidal ideation. In the analysis of sleep duration and sleep time, the odds ratio increased in both genders when sleep duration was <7 hours, and when the time of sleep was later than 24:00 hours. Our results indicate an association between sleep time and duration and AR. This study is the first to focus on the relationship between sleep duration and time and AR in national survey data collected over 6 years.

  20. Clinical analysis of allergic rhinitis in children between 1 and 3 years of age%幼儿变应性鼻炎临床特征分析

    Institute of Scientific and Technical Information of China (English)

    戴伟利; 张杰; 潘岳松; 陈敏; 张亚梅

    2011-01-01

    目的 分析1~3岁变应性鼻炎(allergic rhinitis,AR)患儿的特应性分布状态及其临床特征.方法 采集2009年8月至2010年11月96例1~3岁具有AR症状患儿病史资料,包括就诊年龄、性别、出现症状年龄、病史月数、个人过敏史、父母过敏史.采用敏筛定量过敏原检测系统( Allergy Screen)筛查共计19类吸入组和食物组变应原特异性lgE( specific IgE,sIgE)及血清总IgE水平.归纳该组患儿吸人性变应原和食物变应原致敏的分布状态,按月龄(A组,≥12月龄;B组,≥24月龄;C组,≥36月龄,但不满48月龄)、变应原类别及湿疹或哮喘任一阳性分组分析各临床特征因子的影响作用,Logistic回归方法分析各临床特征与变应原致敏的相互关系.结果 变应原筛查总阳性率为81.3%;吸入组变应原、食物组变应原阳性率分别为62.5%、53.1%;混合真菌阳性率最高(50.0%),其次为牛奶(34.4%)、羊肉(31.3%)、牛肉(26.0%)、屋尘螨(21.0%)、小麦(18.8%)、艾蒿(12.5%)、鸡蛋白或鸡蛋黄(11.5%).62.5%可确诊为AR,其余可暂视为非变应性鼻炎.按月龄分组进行临床特征的单因素分析提示:吸入组变应原(x2=13.699,P=0.001)、父亲患AR(x2=14.060,P=0.001)和父亲或母亲患AR(x2=7.396,P=0.025)在3个月龄组的差异均有统计学意义.个人湿疹史(P=0.034,OR =3.143)可增加变应原致敏的可能性;个人湿疹史(P=0.015,OR=3.125)和总IgE >200 IU/ml(P=0.030,OR =3.119)则增加吸入组变应原致敏的可能性;未筛选出对食物组变应原致敏有统计学意义的临床特征;食物组和吸人组阳性率差异无统计学意义.吸入组变应原阳性(P=0.046,OR=3.594)、有蚊虫叮咬性皮炎(P=0.002,OR=11.941)为出现湿疹或哮喘任一阳性的危险因素.结论 1~3岁具有AR症状的幼儿中,吸入组和食物组变应原均可致敏,且吸入组阳性率略高;湿疹史是患儿变应原筛查阳性的危险因

  1. 青岛市儿童支气管哮喘合并变应性鼻炎问卷调查分析%CHILDREN WITH BRONCHIAL ASTHMA COMPLICATED WITH ALLERGIC RHINITIS IN QINGDAO: A QUESTIONNAIRE INVESTIGATION AND ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    许美; 林荣军; 刘莹莹; 路玲

    2012-01-01

    目的 了解青岛市儿童支气管哮喘合并变应性鼻炎的情况及二者关系.方法 随机抽取2010年5月-2011年10月在我院儿科门诊确诊的年龄≤14岁哮喘病儿372例,其中单纯哮喘232例(Ⅰ组),哮喘合并变应性鼻炎140例(Ⅱ组),选取非呼吸道疾病儿童372例作为对照组(Ⅲ组).通过家长笔答问卷,调查病儿一般情况、伴发疾病、家族史、个人过敏史、治疗情况等.结果 Ⅰ、Ⅱ组有家族及个人药物过敏史者明显多于Ⅲ组(x2=47.11~149.73,P<0.05),Ⅱ组有皮肤过敏史者明显多于Ⅰ组(x2=8.50,P<0.05).哮喘合并变应性鼻炎病儿中有63例(45.0%)先发生变应性鼻炎,55例(39.3%)先发生支气管哮喘.72.1%的哮喘合并变应性鼻炎病儿接受了鼻炎治疗,以单用或联合使用抗组胺药物和使用鼻用糖皮质激素为主要治疗措施.结论 支气管哮喘和变应性鼻炎是同一种疾病在不同部位的表现,两者有一定关联性,积极联合防治,可以提高治疗效果.%Objective To investigate the condition of children suffering from bronchial asthma complicated with allergic rhinitis in Qingdao and the relationship between the two conditions. Methods A random sampling of 372 asthma patients, aged ≤14 years old, confirmed in out-patient department of our hospital, from May 2010 to October 2011 , were divided into simple asthma group (Group 1,232 cases) , bronchial asthma complicated with allergic rhinitis group (Group 2,140 cases) , and 372 children with non-respiratory tract diseases (Group 3) served as controls. A questionnaire was used to survey their parents on genera! condition, concomitant diseases history of allergy, and treatment. Results The history of allergy of individuals and family members were more recorded in groups 1 and 2 than in group 3 (x2=47. 11 — 149. 73,P<0. 05). In group 2, the history of skin allergy was more than that in group 1 (x2 — 8. 50 , P<0. 05). Of the patients with combined

  2. Research on prevalence and related factors in allergic rhinitis%变应性鼻炎患病率及相关因素调查

    Institute of Scientific and Technical Information of China (English)

    王泽海; 林文森; 李书彦; 赵绍成; 王丽; 杨仲刚; 陈杰; 张振富; 于金珍

    2011-01-01

    Objective To obtain the prevalence and related factors in allergic rhinitis (AR) and other allergic diseases in rural area in China through epidemiological investigation with large sample and multi-faceted survey data. Methods Face to face survey was conducted in different regions( rural areas of Cangzhou, Hebei, coastal fishing village of Bohai Bay, area of Wuling Mountain, Chengde, urban areas of Tianjin) from April 2007 to May 2009. In the same time, serum specific IgE(sIgE) was detected in the digits of every 0, 1or 5 in them. SPSS 13.0 software was used to analyze the data. Results Five thousand and ten cases were investigated. There were 823 cases with the symptoms or signs of AR ( 16. 4% ). Four hundred and two cases were found to have positive serum sIgE antibody in 1576 detected cases(25.5% ).One hundred and fourty-six cases with nasal allergic symptoms or signs were diagnosed as AR. The incidence of AR was 9. 3% ( 146/1576 ). The occurrence of allergic symptoms or signs had a significant statistical difference with factors such as age, occupation, atopic constitution ( x2 value were 7. 96, 9. 73, 16. 53,8.95 respectively, all P < 0. 05 ), and it was closely related to lower respiratory tract allergies ( β = 2. 544,P <0. 01 ). The most common allergens were dog and cat epithelium in rural areas and dust mites in city.Conclusions The incidence of AR is higher whether in urban or rural areas, it should be taken seriously as the impact on human health. The occurrence is closely related to physical characteristics and environmental factors.%目的 通过对变应性鼻炎(alkrgic rhinitis,AR)流行病学之大样本的调查,获得以农村为主的AR的患病率及相关患病因素.方法 2007年4月至2009年5月在河北省沧州市农村、渤海湾黄骅市沿海渔村、承德市雾灵山区、天津市区分别以行政乡、村和街道、居民小区等为单位,按行政乡、村和街道、居民小区名册通过随机多级抽样和整群

  3. Allergic disease as an association of steroid sulphatase deficiency.

    Science.gov (United States)

    Sakura, N; Nishimura, S; Matsumoto, T; Ohsaki, M; Ogata, T

    1997-11-01

    Ten of 31 patients with steroid sulphatase (STS) deficiency were found to have an allergic disease (bronchial asthma, allergic rhinitis, or atopic dermatitis). STS deficiency may predispose patients to allergic disease.

  4. 腹针治疗变应性鼻炎82例临床观察%Clinical observation on treating 82 cases of allergic rhinitis by abdominal acupuncture therapy

    Institute of Scientific and Technical Information of China (English)

    杨小清; 王维明; 黎婵

    2013-01-01

      目的:观察腹针引气归元法治疗变应性鼻炎82例。方法:采用腹针疗法治疗2周。结果:大部分患者经2个疗程治疗都取得了较好的疗效,82例患者中痊愈48例,占58.7%;有效29例,占35.6%;无效5例,占5.7%。总有效率为94.3%。结论:腹针治疗变应性鼻炎效果显著。%Objective:To investigate clinical effects of the abdominal acupuncture entraining return element method on treating 82 cases of allergic rhinitis. Methods:Take the abdominal acupuncture entraining return element therapy for 2 weeks. Results:Most patients after two courses of treatment have achieved better results, 48 cases were cured(58.7%), 29 cases were effective(35.6%), 5 cases have no effect (5.7%). The total efficiency was 94.3%. Conclusion: The abdominal acupuncture therapy was significantly effective in treating allergic rhinitis.

  5. Systematic evaluation of the randomized controlled trials about acupuncture and moxibustion treatment of allergic rhinitis%针灸治疗变应性鼻炎临床随机对照试验系统评价

    Institute of Scientific and Technical Information of China (English)

    肖丽; 黎波; 杜元灏; 熊俊; 高翔

    2009-01-01

    Objective To evaluate the clinical effect and safety of acupuncture and moxibustion treatment for allergic rhinitis and to analyze the present situation of clinical researches. Methods A search in PubMed, Cochrane Library, Chinese Biology Medicine (CBM) disk, and China National Knowledge Infrastructure (CNKI) databases was performed to gather the randomized controlled trials about acupuncture and moxibustion treatment for allergic rhinitis, identify additional clinical trials met the inclusion criteria and measure their qualities by using Cochrane Reviewers' Handbook 5. 0. Statistical analysis was carried out by RevMan 4. 2. 8. Results A meta-analysis was performed on a total of 1 076 patients involved in 12 papers which met the inclusion criteria. There were significant differences in both cure rate (Incorporate RR=1. 86, 95%CI 1. 51, 2. 29, Z=5. 82, P<0.000 01) and marked improvement rate (Incorporate RR=1.58, 95%CI 1.32, 1.89, Z=4.94, P<0. 00001) between acupuncture and moxibustion treatment and the routine medicine treatment for allergic rhinitis. Conclusion Acupuncture and moxibustion to treat allergic rhinitis is effective and safe and may have certain advantage over the routine medicine treatment. However, as for the low quality of partial inclusion literatures, no definite conclusion can be obtained as yet and it still waits for higher quality researches to further prove the dominance of acupuncture and moxibustion treatment for allergic rhinitis.%目的:评价针灸治疗变应性鼻炎的临床疗效及安全性,分析目前临床研究的现状.方法:检索PubMed、Cochrane图书馆、CBM数据库、CNKI数据库等收集针灸治疗变应性鼻炎临床随机对照试验,选择符合纳入标准的临床试验,以Cochrane系统评价手册5.0进行质量评价,统计学分析采用RevMan 4.2.8.结果:12篇文献符合纳入标准,共1 076例患者.Meta分析显示针灸治疗变应性鼻炎与常规药物治疗治愈率比较,差异有统计学意

  6. Qualitative Development of the Rhinitis Control Assessment Test (RCAT), an Instrument for Evaluating Rhinitis Symptom Control

    OpenAIRE

    Nathan, Robert A; Dalal, Anand A; Stanford, Richard H; Meltzer, Eli O.; Michael Schatz; Jennifer Derebery; Matthew Mintz; Michelle A. Thompson; Dana B. DiBenedetti

    2010-01-01

    Background: Effective management of allergic rhinitis requires ongoing monitoring of its control. This article describes the qualitative phase of development of a patient-completed instrument, the Rhinitis Control Assessment Test (RCAT), designed to assist patients and providers in the detection of problems with rhinitis symptom control. Objective: To identify concepts to be measured and to develop initial questionnaire items to be tested further in the next phase of development. Methods: A l...

  7. 孔嗣伯老中医清热化湿通窍法治疗变应性鼻炎经验%Experience of Notable TCM Doctor Kong Sibo in Treating Allergic Rhinitis by Removing Heat Dampness and Relieving Stuffy Nose

    Institute of Scientific and Technical Information of China (English)

    段颖; 支楠

    2014-01-01

    孔嗣伯老中医治疗变应性鼻炎经验丰富,疗效显著。孔老认为变应性鼻炎属中医鼻鼽范畴,湿热内蕴是鼻鼽发生的重要病因病机,称之湿热鼻鼽。清热化湿通窍是治疗湿热鼻鼽的总则,临床治疗应注意整体观念,多因素考虑,辨别湿热所在脏腑经络而遣方用药。%Dr.Kong Si bo,is a veteran practitioner of traditional Chinese medicine,who has rich experience in treating curative effect of allergic rhinitis.Dr.Kong believes that allergic rhinitis belongs to Bi Qiu category of traditional Chinese medicine,and the interior reten-tion of damp heat is the main important pathogenesis of allergic rhinitis.Clearing heat and dampness and relieving stuffy nose is the gen-eral principles of treating damp heat of allergic rhinitis.As for clinical treatment,attention shall be paid to the integrated conception,mul-tiple factors to identify the damp heat position of meridians and collaterals including the viscera system.

  8. [Allergic rhinitis in asthmatic patients].

    Science.gov (United States)

    Reyes, Paola; Larreal, Yraima; Arias, Julia; Rincón, Enrique; Valero, Nereida

    2014-01-01

    Antecedentes: la rinitis alérgica y el asma bronquial son procesos inflamatorios crónicos de las vías respiratorias, con una correlación que varía entre 28 y 78%. Objetivos: determinar la prevalencia de rinitis alérgica en pacientes asmáticos y clasificarla según las guías Rinitis Alérgica y su Impacto en Asma (ARIA), así como detectar las concentraciones séricas de IgE total y la existencia de eosinofilia nasal y en sangre periférica. Material y método: estudio en el que pacientes asmáticos entre 7 y 14 años de edad, consultantes del servicio de Pediatría del Hospital General del Sur Dr. Pedro Iturbe, Maracaibo, Estado Zulia, Venezuela, fueron encuestados acerca de signos y síntomas sugerentes de rinitis alérgica y su efecto en la calidad de vida. Se tomaron muestras sanguíneas e hisopado nasal para hacer las determinaciones objeto de estudio. Resultados: se evaluaron 60 pacientes asmáticos, 73.3% del sexo masculino y 70% escolares. La prevalencia de rinitis alérgica se estableció en 93.3%, el tipo más frecuente según ARIA fue el intermitente leve, con 42.8%. El signo clínico más frecuente fueron las ojeras alérgicas (86.6%) y el síntoma predominante fue el goteo nasal acuoso (83.3%), la afectación en cuanto a calidad de vida estuvo representada por trastornos del sueño (39.2%). El 85.7% de los encuestados tuvo porcentajes de eosinófilos mayores a 3% y 75% tuvo valores mayores de 100 UI de IgE total sérica. El 61.9% de las muestras de moco nasal de pacientes con rinitis mostró porcentajes de eosinófilos mayores a 10%. Conclusión: existe alta prevalencia de rinitis alérgica en asmáticos confirmada mediante pruebas de laboratorio que evidencian una respuesta inflamatoria mediada por IgE.

  9. Allergic rhinitis - self-care

    Science.gov (United States)

    Antihistamines are medicines that work well for treating allergy symptoms. They are often used when symptoms do ... pill, capsule, or liquid without a prescription. Older antihistamines can cause sleepiness. They may affect a child's ...

  10. On the methods of epidemiological survey on allergic rhinitis%变应性鼻炎流行病学调查方法商榷

    Institute of Scientific and Technical Information of China (English)

    王泽海; 林文森; 王丽

    2012-01-01

    Objective To investigate the practically feasible methodology for epidemiological survey on the accurate prevalence and related predisposing factors of allergic rhinitis (AR) in a comparative way among several surveying Methods used in our investigation. Methods The survey was carried out in a population with 5230 of cases, out of the villagers in Qingxian County, Hebei Province, fishermen in coastal lines of Huanghua City, Bohai Bay, mountainous people in Wulingshan area, Chengde City, and urban residents in Tianjin, from Apr. 2007 to May 2010, by face to face survey to investigate the prevalence and related predisposing factors of AR. Then, 1524 of cases was randomly selected from them to detect their specific IgE (sIgE) level in serum. Results In this group of cases surveyed, 9.1% were diagnosed clinically with AR, while 16.7% in this group of cases were determined with clinical manifestation of AR as shown by face to face survey, with very significant statistical difference (x2=52.21, P<0.01) between them. Among those cases received serum detection of sIgE, 11.5% (176/1524) were seen with AR symptoms but with a negative result of sIgE test. Conclusions The survey method of face to face interview will provide a relatively accurate epidemiological conclusion on the prevalence of AR at a higher level as closer as to its actual incidence, when combined with laboratory test on sIgE content in serum.%目的 分别对不同的变应性鼻炎流行病学调查方法及其结果进行比较,准确评价变应性鼻炎患的病率与相关患病因素.方法 2007年4月~2010年5月,通过随机整群和分层抽样,对河北省沧州市农民、渤海湾黄骅市沿海渔民、承德市雾灵山区居民、天津市区市民5230人进行变应性鼻炎患病率及相关患病因素直接面访调查,并随机检测1524例受调查者血清sIgE.结果 临床确诊调查地区变应性鼻炎患病率为9.1%,而直接面访调查获得的有关症状发生率为16.7

  11. 金双歧治疗儿童慢性过敏性鼻炎临床研究%Clinical Study of Jin Shuangqi Therapy in Children with Chronic Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    张丽丽; 刘肇杰; 李海峰; 宋敏

    2013-01-01

    Objective:To observe the clinical effect of golden bifid in the treatment of children with chronic allergic rhinitis. Methods:84 patients were randomly divided into treatment group of 42 cases and control group 42 of cases. The control group oral loratadine and traditional Chinese medicine,the treatment group in the control group on the basis of oral live combined bifidobacterium and Lactobacillus bacteria (Bifidobacterium). To observe the therapeutic effect of the two groups. Results:The effective rate of treatment group 97. 6% , control group was 83.3% ,the two groups,the difference was statistically significant(P <0.01). Conclusion:Golden bifid in treatment of children with chronic allergic rhinitis curative effect.%目的:观察金双歧治疗儿童慢性过敏性鼻炎的临床疗效.方法:将84例患儿随机分为对照组42例和治疗组42例.对照组口服氯雷他定及中药,治疗组在对照组的基础上口服双歧杆菌乳杆菌三联活菌片(金双歧).结果:治疗组有效率为97.6%,对照组有效率为83.3%,两组有效率比较,差异有统计学意义(P<0.01).结论:金双歧治疗儿童慢性过敏性鼻炎疗效显著.

  12. 246 Assessment of the Quality of Methodological Rigour and Reporting of Clinical Practice Guidelines for the Management of Allergic Rhinitis—Qugar Study

    OpenAIRE

    Padjas, Agnieszka; Schünemann, Holger,; Bousquet, Jean; Brozek, Jan

    2012-01-01

    Background To assess the methodological rigour and transparency of reporting in clinical practice guidelines for the management of allergic rhinitis (AR). Methods We systematically searched MEDLINE, TRIP database (including the National Guidelines Clearinghouse) and professional society websites for guidelines about the management of AR published after the year 2000. We assumed that older guidelines would no longer influence current clinical practice. If the guideline was updated after 2000 w...

  13. Lung function analysis and epidemiological survey of patients with bronchial asthma combined with allergic rhinitis in Tianjin area%天津地区支气管哮喘合并过敏性鼻炎的流行病学调查及肺功能分析

    Institute of Scientific and Technical Information of China (English)

    周宁; 曹洁; 陈宝元; 朱宝玉; 邓园

    2012-01-01

    目的 了解天津地区支气管哮喘(简称哮喘)合并过敏性鼻炎(allergic rhinitis,AR)的流行病学情况,分析两者之间的临床相关性及对肺功能的影响.方法 对天津地区142例哮喘患者进行哮喘合并过敏性鼻炎流行病学问卷调查及肺功能测定,了解患者的认知情况、治疗现状和肺功能状况,并建立相应的个人数据库档案,对数据进行统计学分析.结果 142例哮喘患者中,有97例合并过敏性鼻炎(68%),其中60例为鼻炎发病在先,占哮喘合并鼻炎患者的61.9%.哮喘合并鼻炎组和单纯哮喘组两组患者在性别、年龄和哮喘病史方面比较差异无统计学意义(P>0.05),但哮喘合并鼻炎组的组间比较显示鼻炎史显著长于哮喘史,差异有统计学意义(P<0.05).与单纯哮喘组相比,鼻炎合并哮喘组的哮喘控制测试(asthma control test,ACT)评分明显偏低,差异有统计学意义(P<0.05).与单纯哮喘组相比,哮喘合并鼻炎组患者的呼气峰流速(peak expirationg flow,PEF)显著下降,吸入性糖皮质激素量减低,小气道敏感指标肺活量为75%时最大呼气流量(MEF75%)和MEF50%显著降低,而脉冲振荡频率在20 Hz时呼吸阻力(R20)增高.过敏性鼻炎与哮喘严重程度呈明显的正相关(rs=0.604,P<0.01).结论 过敏性鼻炎多在哮喘之前发生,其与哮喘严重程度具有高度的一致性,是引发哮喘的一项重要危险因素.哮喘合并过敏性鼻炎患者的ACT评分显著低于单纯哮喘患者,并且过敏性鼻炎进一步导致了肺通气功能的下降及气道阻力增加,提高了哮喘的控制难度.%Objective To study the epidemiology of allergic rhinitis in bronchial asthma patients from Tianjin and to analyze the correlation of clinical characteristics as well as the lung function between allergic rhinitis and bronchial asthma.Methods A questionnaire survey of 142 bronchial asthma patients from the city of Tianjin was carried out

  14. 儿童分泌性中耳炎与变应性鼻炎相关研究进展%Advances in Clinical Research on Otitis Media with Effusion and Allergic Rhinitis in Children

    Institute of Scientific and Technical Information of China (English)

    李颖; 赵守琴

    2016-01-01

    分泌性中耳炎是儿童的常见病与多发病,是引起儿童听力下降的常见原因之一。为深入了解儿童分泌性中耳炎与变应性鼻炎之间的内在联系,本文收集了相关研究文献。研究表明分泌性中耳炎与变应性鼻炎之间存在流行病学、病理生理学方面的联系,抗过敏治疗对分泌性中耳炎具有短期疗效并可有效防止分泌性中耳炎复发。采用鼻内类固醇激素治疗后,其治愈率明显增加。这些发现为人们深入研究变态反应性疾病与分泌性中耳炎形成机制间的联系、抗过敏治疗对复发性分泌性中耳炎的有效性以及针对该病更广泛的药物治疗研究提供了重要参考。%Otitis media with effusion is a common and frequently occurring disease in children, and one of the most common causes of hearing loss in the pediatric population. To further understand the relationship between otitis media with effusion and allergic rhinitis in children, relevant research literature was reviewed. Research shows that, from epidemiology and pathophysiology evidence, otitis media with effusion and allergic rhinitis are related, and treatments against allergy are beneficial for otitis media with effusion in short-term and can effectively prevent its recurrence. The rate of recovery from otitis media with effusion is significantly increased after treatment with steroids. These findings provide an important refer-ence for further studies of the relationship between allergic diseases and the mechanisms of pathogenesis of otitis media with effusion, the effectiveness of anti-allergy treatments for recurrent otitis media with effusion, and development of addi-tional medical treatments for the disease.

  15. Effects of topical administration of beclomethazone dipropionate on the symptoms of chronic rhinitis

    OpenAIRE

    Ursulović Dejan D.; Janošević Ljiljana B.; Janošević Slobodanka B.; Đukić Vojko

    2003-01-01

    The aim of this study was to evaluate the effect of topical administration of corticosteroid beclomethasone dipropionate on common nasal symptoms in moderate allergic and non-allergic hyperreactive eosinophilic rhinitis, and in allergic and non-allergic hyperreactive eosinophilic rhinitis associated with bilateral moderate nasal polyposis. The study was prospective and controlled. During the study 106 patients were examined, out of whom 66 were treated, while 40 had no therapy. Beclomethasone...

  16. Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response

    DEFF Research Database (Denmark)

    Bourke, C.D.; Mutapi, F.; Nausch, N.;

    2012-01-01

    Parasitic helminths have been shown to reduce inflammation in most experimental models of allergic disease, and this effect is mediated via cytokine responses. However, in humans, the effects of controlled helminth infection on cytokine responses during allergy have not been studied.......Parasitic helminths have been shown to reduce inflammation in most experimental models of allergic disease, and this effect is mediated via cytokine responses. However, in humans, the effects of controlled helminth infection on cytokine responses during allergy have not been studied....

  17. 广东惠州地区成人支气管哮喘合并过敏性鼻炎的流行病学调查分析%Epidemiology analysis of patients with bronchial asthma combined with allergic rhinitis in Huizhou

    Institute of Scientific and Technical Information of China (English)

    吴峰; 林伟明; 陈宫玉; 陈钊成; 陈必达; 周五铁; 吴思仿; 吴海桂

    2012-01-01

    Objective To study the status of bronchial asthma (asthma) in patients with allergic rhinitis in Huizhou,and to analyze the correlation of clinical characteristic between allergic rhinitis and bronchial asthma,to investigate the patients' cognitions and treatment situation about the allergic rhinitis.Methods The questionnaire survey of 280 cases of asthma in Huizhou,their medical history,severity,asthma control test (ACT) were investigated in details.The rhinitis survey included prevalence,cognition,family history and treatment situation.The patients,data were collected and analyzed.Results In 280 cases of bronchial asthma,203 cases(72.5%) combined with allergic rhinitis.There was no statistical significance ( P >0.05) between the group of asthma combined with allergic rhinitis and the group of simple asthma on the age,sex,and the disease course.Compared with the group of simple asthma on case,the group of asthma combined with allergic rhinitis were more cases at the grade 2(mild persistence),grade 3(moderate persistence),and grade 4 (severe persistence),and few cases in complete control,good control through ACT ( P <0.05),while more cases in the uncontrol through ACT ( P <0.05).Allergic rhinitis:in the the group of asthma combined with allergic rhinitis,there were 59.61% of the patients got allergic rhinitis earlier than asthma,about 17.24% got those two disease at the same time.The inducements of allergic rhinitis were cold air (82.10%),irritant gas (61.58%),about 25.62% patients had been allergen tested,56.65 % patients had used drug treatment.27.10 % patients had family history of asthma or allergic rhinitis.Conclusions The morbidity of asthma combining with allergic rhinitis is high in Huizhou city,the cognition is low,and treatment status are not optimistic,which can be the basis of prevention and treatment in future.%目的 了解惠州地区支气管哮喘(简称哮喘)患者合并过敏性鼻炎的情况,分析两者在临床表现

  18. Analysis of allergens among 3 ~ 7 years old children with allergic rhinitis in Urumqi%乌鲁木齐市3~7岁过敏性鼻炎患儿过敏原检测分析

    Institute of Scientific and Technical Information of China (English)

    高越; 廖建军; 徐佩茹

    2013-01-01

    [目的]了解乌鲁木齐市3~7岁过敏性鼻炎患儿过敏原的分布状况,为儿童过敏性鼻炎的防治提供科学依据. [方法]采用体外特异性过敏原检测试剂盒对176例过敏性鼻炎患儿进行吸入过敏原检测,其中90例患儿同时行食物过敏原检测. [结果]176例过敏性鼻炎患儿吸入过敏原测试总阳性率为99.4%,以螨混合(屋尘螨+粉尘螨)最高(61.9%),其后依次为蟑螂(53.4%),霉菌混合(点青霉+烟曲霉+交链孢酶)(46.6%),梧桐(41.5%),榆树(38.1%),狗上皮(31.8%),猫毛和豚草均为(17.0%),艾蒿(1 6.5%),葎草(11.9%)等.90例患儿食物过敏原的总阳性率为84.4%,过敏原主要为小麦和花生均为(54.4%),其次为鸡蛋和大豆分别为(50.0%)、(42.2%),坚果混合和牛奶(分别为31.1%、23.3%),蟹(16.7%),西红柿(11.1%),鳕鱼和虾均为(8.9%)等. [结论]螨为乌鲁木齐市3~7岁过敏性鼻炎患儿最主要的过敏原,食物过敏亦占相当比例.明确过敏原后对托幼机构开展卫生消毒和预防保健工作具有重要的指导意义.%[Objective] To analyse the allergens among 3~7 years old children with allergic rhinitis and provide scientific basis for prevention in Urumqi.[Method] A total of 176 children with allergic rhinitis was recruited for the inhaled reactions and 90 cases of them had the food tests at the same time.[Results] The total positive rate of the inhaled tests was 99.4 % among the 176 cases with allergic rhinitis.The highest positive rate was mites 61.9 %.The positive rate of other allergens were:blackbeetle 31.7%,fungi 46.6%,phoenix tree 41.5%,elm 38.1%,dog coat 31.8%,cat coat and ragweed 31.8%,arlemisia 16.5%,scandent hop 11.9%.The total positive rate of the food tests was 84.4% among the 90 cases with allergic rhinitis.The positive rate of wheat and peanut (54.4 %) was the highest.The positive rate of heneggs,pea,nut,cow,smilk,crab,tomato,cod fish and shrimp

  19. Effects of Xanthium sibiricum nasal drops on allergic rhinitis in guinea pigs%复方苍耳子滴鼻剂对豚鼠变应性鼻炎的影响

    Institute of Scientific and Technical Information of China (English)

    李道佩; 戴卫波; 吴又明

    2012-01-01

    Objective To determine the effects of compound Xanthii sibiricum nasal drops on changes in symptoms and serum histamine level in allergic rhinitis guinea pig models. Methods The guinea pig nasal mucosal allergy model was established by using toluene-2,4-diisocyanate (2, 4-TDI) as a sensitizer. The level of histamine and morphohistological changes of each group were determined, with model group, positive drug group and blank control group regarded as controls. Results For nasal symptoms, both high and low dosage of compound Xanthii sibiricum nasal drops were associated with significant improvement in post-treatment total score when compared with pre- treatment levels (both P<0.05), suggesting marked recovery of overall symptoms in chronic rhinitis animal models. Both high and low dosage of compound Xanthii sibiricum nasal drops have, in terms of the impact on serum histamine lev -el, resulted in considerably lower figures than model group (P<0.05 or 0.01), indicating significant attenuation of serum histamine in chronic rhinitis animal model. Additionally, both high and low dosage of compound Xanthii sibiricum nasal drops have led to morphohistological improvements with regard to epithelial metaplasia, hyperplasia of glands, vascular hyperplasia or dilatation as well as inflammatory cell counts in nasal mucosa. Conclusion Experimental allergic rhinitis in rats may benefit considerably from compound Xanthii sibiricum nasal drops treatment.%目的 观察复方苍耳子滴鼻剂对变应性鼻炎模型豚鼠症状的变化和血清组胺含量的影响.方法 以甲苯-2,4-二异氰酸甲苯酯(TDI)作为致敏因子建立豚鼠鼻黏膜变态反应模型,以模型组、阳性药物组与空白组为对照,测定各组豚鼠鼻黏膜内组胺的含量及形态组织学的改变.结果 ①鼻部症状的改善情况:复方苍耳子滴鼻剂高、低剂量组药前总评分与药后总评分比较差异有统计学意义(P<0.05),能显著性改善慢性鼻炎模型动

  20. Influence of corticosteroids on system of cortisol-growth hormone in children withAllergic rhinitis%糖皮质激素鼻喷雾剂对儿童肾上腺皮质功能的影响

    Institute of Scientific and Technical Information of China (English)

    张文; 韩想莉; 刘晖; 李世东; 高小娥; 丁瑜

    2012-01-01

    目的:探讨应用糖皮质激素对变应性鼻炎儿童皮质醇、生长激素(GH)及身高的影响.方法:变应性鼻炎患儿25例(观察组)给予布地奈德鼻喷雾剂治疗,每鼻孔1掀,2次/d,疗程4周.同时口服氯雷他定糖浆,用药剂量为0.11~0.24mg/kg,1次/d,用药4周.治疗前和治疗后6个月采静脉血5ml,采用放射免疫分析法(RIA)测定其血清皮质醇、生长激素(GH)水平,应用标准法测量并记录观察组及对照组身高.结果:观察组儿童用药前及用药6个月后其血清皮质醇和GH水平均无显著性差异.观察组身高治疗前、治疗后6个月时与对照组儿童身高比较无显著性差异.结论:糖皮质激素对变应性鼻炎儿童血清皮质醇和GH及身高的生长发育无明显影响.%Objective: To explore the changes of cortisol-growth hormone before and after corticosteroids in children with allergic rhinitis and to observe the variation of height between sick children and healthy children. Methods: Twenty-five children with allergic rhinitis were collected as observation group, and the patients were re-ceived budesonide one spray per nostril, two times per day for 4 weeks. Meanwhile these children took orally lorata dine syrup for 4 weeks. The serum blood were collected before treatment and after treatment 6 months; the contents of cortisol and growtn normone (GH) were measured by radio immunoassay(RIA). Tne heignt was measured and recorded by standard method. Results: The levels of serum cortisol and GH in children with allergic rhinitis had no significant differences before and after 6 months therapy. The height of children in observation group and control group which were healthy and had the same age and gender had no significant differences before therapy and after 6 months therapy. Conclusions:The serum consentbations of cortisol and GH in children suffered from allergis rhini tis have no obvious change before and after 6 months budesonide spray. The height changes

  1. 走罐配合姜汁敷擦治疗变应性鼻炎疗效观察%Therapeutic Observation of Moving Cupping with Applying Ginger Juice for Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    范少挺

    2016-01-01

    目的:观察走罐配合姜汁敷擦治疗变应性鼻炎的临床疗效。方法将60例变应性鼻炎患者随机分为治疗组和对照组,每组30例。治疗组先用姜汁敷擦后背部膀胱经区域皮肤,然后采用走罐治疗,以起痧为度。对照组采用口服氯雷他定分散片治疗。观察两组治疗前后症状评分,并比较两组临床疗效。结果治疗组治疗后各项症状(喷嚏、流涕、鼻堵、鼻痒)评分与同组治疗前比较,差异均具有统计学意义(P<0.05,P<0.01)。对照组治疗后喷嚏、流涕及鼻痒评分与同组治疗前比较,差异具有统计学意义(P<0.05)。治疗组治疗后流涕和鼻堵评分与对照组比较,差异均具有统计学意义(P<0.01)。治疗组总有效率和显效率分别为90.0%和70.0%,对照组分别为70.0%和33.3%,两组比较差异均具有统计学意义(P<0.05)。结论走罐配合姜汁敷擦是一种治疗变应性鼻炎的有效方法。%Objective To observe the clinical efficacy of moving cupping with applying ginger juice in treating allergic rhinitis. Method Sixty patients with allergic rhinitis were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by moving cupping applied after the Bladder Meridian on the back was rubbed with ginger juice, till appearance of Sha-spots. The control group was by oral administration of Loratadin tablets. Before and after intervention, the symptoms were scored, and the clinical efficacies were compared between the two groups.Result The symptom scores (sneeze, running nose, stuffy nose, and itchy nose) were significantly changed after intervention in the treatment group (P<0.05,P<0.01). After intervention, the scores of sneeze, running nose, and itchy nose in the control group were significantly different from that in the treatment group (P<0.05). The running nose and stuffy nose scores of the treatment group were significantly different form that of

  2. Clinical efficacy of improved incision septoplasty for patients with allergic rhinitis%改良切口鼻中隔成形术治疗变应性鼻炎

    Institute of Scientific and Technical Information of China (English)

    王爱平; 孙海波

    2016-01-01

    Objective To analyze the clinical efficacy of improved incision septoplasty in treatment of allergic rhinitis and its effect on the life quality of patients.Methods A total of 42 patients with persistent allergic rhinitis and merge nasal septum in our hospital from July 2013 to April 2015 were divided into observation group and control group.The observation group were treated by improved incision septoplas-ty,and the control group received traditional KillIan incision treatment.The clinical efficacy,survival quality and visual analog scale between two groups were compared.Results After treatment,The total efficiency rate of observation group(94.24%)was significantly higher than that of control group(85.71%)(χ2 =7.15,P <0.05).The nasal congestion,nasal itching,sneezing and other symptoms score of observa-tion group were significantly lower than those of control group(P <0.05).The score of nasal problems,eye problems,eye problems and non-nasal sleep disorders in observation group were also significantly lower than those in control group(P <0.05).Intraoperative situation of ob-servation group was significantly better than that of control group(P <0.05).Conclusion Improved incision septoplasty has a good clinical efficacy for patients with persistent allergic rhinitis and merge nasal septum,which can significantly improve the clinical symptoms and life quality of patients.%目的:分析改良切口鼻中隔成形术治疗变应性鼻炎的临床疗效及对患者生存质量的影响。方法选取2013年7月至2015年4月在我院耳鼻喉科手术治疗的42例持续性中重度合并鼻中隔偏曲的变应性鼻炎患者,按手术方式不同分为观察组和对照组,观察组给予改良切口鼻中隔成形术治疗,对照组给予传统 KillIan 切口单纯鼻中隔黏膜切除术治疗,对2组患者的临床疗效,生存质量及视觉模拟评分进行比较。结果治疗后观察组总有效率94.24%,显著高于对照组的85.71

  3. Effect of steroid nasal spray on pediatric allergic rhinitis in children with adenoidal hypertrophy%鼻用类固醇治疗儿童变应性鼻炎伴腺样体肥大疗效分析

    Institute of Scientific and Technical Information of China (English)

    韦一; 王德乐; 王韶鉴; 曾莉

    2015-01-01

    Objective To evaluate the curative effect of steroid nasal spray on pediatric allergic rhinitis with adenoidal hypertrophy.Methods A total of 261 children with adenoids served as the control group,of them,190 children (72.7%)were with adenoid hypertrophy.A total of 162 children with allergic rhinitis and adenoids served as the ex-perimental group,of them,110 children(67.2%)were with adenoid hypertrophy.The two groups were both treated by Fluticasone propionate nasal spray (50 μg per nostril a day)for 3 months.Results Adenoidal hypertrophy incidence was 72.7% in the control group and 67.2% in the experimental group (χ2 =1.16,P >0.05).112 (58.9%)patients in the control group and 89 (80.9%)patients in the experimental group had the adenoidal volume decreased (χ2 =19.04,P <0.01).Conclusion After steroid nasal spray treatment,the adenoidal volume is much more decreased in the experimental group than in the experimental group.Steroid nasal spray is the first choice for children with allergic rhinitis and adenoidal hypertrophy.%目的:探讨儿童变应性鼻炎(AR)与腺样体肥大的关系,评价鼻用类固醇治疗儿童变应性鼻炎伴腺样体肥大的疗效。方法对照组为单纯腺样体生长儿童261例,其中腺样体肥大190例(72.7%)。观察组为变应性鼻炎伴腺样体生长儿童162例,其中腺样体肥大110例(67.2%)。两组均给予鼻用类固醇(丙酸氟替卡松喷剂)持续喷鼻3个月后于鼻内镜下复查。结果对照组并发腺样体肥大构成比为72.7%,观察组并发腺样体肥大构成比为67.2%,差异无统计学意义(χ2=1.16,P >0.05)。对照组采用鼻用类固醇治疗后有效腺样体体积减少112例(58.9%),观察组有效腺样体体积减小89例(80.9%)(χ2=19.04,P <0.01)。结论经鼻用类固醇治疗,变应性鼻炎伴腺样体肥大患儿腺样体体积减小程度较单纯腺样体肥大患儿明显。对

  4. 变应性鼻炎儿童的智力结构与个性特征分析%Analysis of intelligence structure and personality characteristics of children with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    刘萍; 郭杰峰; 吴郁丽; 伍慧卿

    2016-01-01

    Objective To study the intelligence structure and personality characteristics of children with allergic rhinitis.Methods 126 children who were diagnosed as allergic rhinitis were divided into mild group and moderate to severe group according to the severity of the disease. And 45 healthy children were selected as control group. The mild group、moderate to severe group and control group were evaluated with the Chinese Version Wechsler Intelligence Scale for Children(C - WISC)and Eysenck Personality Questionnaire(EPQ). Results Compared with the control group,there was no statistical difference in full scale intelligence quotient (FIQ)、verbal scale intelligence quotient( VIQ)、performance scale intelligence quotient( PIQ),subtests of C - WISC and the unbalance between VIQ and PIQ incidence rate in mild group(P > 0. 05),but there was statistically significant difference in full scale intelligence quotient(FIQ)、verbal scale intelligence quotient(VIQ)、performance scale intelligence quotient(PIQ)between moderate to severe group and control group(P 0. 05),compared with the control group,the score of psychoticism and neuroticism of the moderate to severe group was higher,however,the score of introversion - ex - traversion was lower,and the difference was statistical significant (P 0.05);中重度组与对照组相比,总智商(FIQ)、言语智商(VIQ)、操作智商(PIQ)差异有统计学意义(P 0.05);中重度组与对照组相比,精神质维度评分高,内外向维度评分低,神经质维度评分高,差异有统计学意义(P <0.05)。结论中重度持续性变应性鼻炎儿童智商水平普遍偏低,患儿智力结构损害以知识、领悟、词汇为代表的反映言语理解因子和以算术、数字广度、编码为代表的反映记忆/注意因子方面为主,智力结构发展不平衡;患儿人格特质以情绪不稳、敏感、孤僻等抑郁质倾向为主。

  5. 蒿属花粉过敏变应性鼻炎与HLA-DRB基因多态性的相关性研究%Linkage of allergic rhinitis with HLA-DRB alleles polymorphism

    Institute of Scientific and Technical Information of China (English)

    邢志敏; 于德林

    2001-01-01

    目的:研究HLA-DRB基因型在北京地区蒿属花粉过敏变应性鼻炎患者中的分布。方法:用聚合酶链反应-序列特异性引物技术(PCR-SSP),检测HLA-DRB基因型在41例以蒿属花粉过敏为主的变应性鼻炎患者(变应性鼻炎组)及41例正常健康者(对照组)中的分布,并分析二者间的分布差异。结果:变应性鼻炎组HLA-DRB 10301.2及HLA-DRB 40101基因频率分别为1.22%和29.27%,明显低于对照组(8.54%和51.22%),其差异有显著性意义(P<0.05)。结论:HLA-DRB10301.2及HLA-DRB 40101基因可能是变应性鼻炎发病的抗性基因。%Objective:To investigate whether susceptibility or resistance to allergic rhinitis associated with HLA-DRB alleles.Method:Using PCR-SSP (sequence-specific primer polymerase chain reaction),we tested the frequency distribution of HLA-DRB alleles in 41 patients with allergic rhinitis (AR) and 41 healthy controls from Beijing China.Result:The frequence of HLA-DRB10301.2 and HLA-DRB 40101 was lower in AR than in controls (2.44% vs 17.07%, P<0.05;29.27% vs 51.22%, P<0.05).Conclusion:HLA-DRB10301.2 and HLA-DRB 40101 alleles might confer protection against AR.

  6. Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis

    DEFF Research Database (Denmark)

    Mørtz, Charlotte G; Lauritsen, J M; Bindslev-Jensen, C;

    2001-01-01

    associated. A considerable number of adolescents still suffers from AD, and a considerable sex difference was noted for hand eczema and allergic contact dermatitis. Nickel allergy and perfume allergy were the major contact allergies. In the future this cohort of eighth grade school children will be followed...

  7. Effects of Treatment of Allergic Rhinitis on the Control of Bronchial Asthma%治疗儿童变应性鼻炎对支气管哮喘控制的影响

    Institute of Scientific and Technical Information of China (English)

    王成林; 江剑桥; 文勃; 康照

    2011-01-01

    Objective To observe the effect of treatment of allergic rhinitis (AR) on the control of bronchial asthma(BA). Methods From January 2009 to May 2010, 65 infantile bronchial asthma and allergic rhinitis were randomly divided into observation group (n= 35) and control group(n= 30). There had no significant difference of age, gender, degree of bronchial asthma severity before treatment, lung function [peak expiratory flow (PEF)] between two groups (P>0. 05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Centre for Ya' an People' s Hospital of Sichuan Province. Informed consent was obtained from all participants. Both groups received regular use of inhaled with fluticasone propionate aerosol (100-500) μg/d according to degrees of bronchial asthma severity.Observation group simultaneously with budesonide nasal spray on both sides of the nose, each one gush (64 μg/spray) for the first month, twice a day. In the second month, both sides of the nose, a spray once a day, and in the third month every other day on both sides of the nose. The treatment lasted for 3 months.After treatment for 6 months, clinical curative effects and pulmonary function changing of two groups were observed. Results Total effectiveness was 94. 2% (33/35) for observation group and 73. 3% (22/30) for control group with a significant difference (P<0. 05). Lung function improvement (peak expiratory flow)after the treatment between observation group [(85.73± 5. 42)%] and control group [(81. 95 ± 4. 31)%]had a statistically significant difference (P<0. 05). Conclusion Children with bronchial asthma and allergic rhinitis should receive active treatment to control bronchial asthma.%目的 观察治疗儿童变应性鼻炎(allergic rhinitis,AR)对支气管哮喘(bronchial asthma,BA)控制的影响.方法 2009年1月至2010年5月将65例在本院耳鼻咽喉科确诊为支气管哮喘伴变应性鼻炎患儿,将其随机分为观察组(n=35

  8. Recent progress in pathophysiological study of vasomotor rhinitis%血管运动性鼻炎的研究进展

    Institute of Scientific and Technical Information of China (English)

    程雷; 陶绮蕾; 王云丽

    2010-01-01

    @@ 血管运动性鼻炎(vasomotor rhinitis,VMR)属于非变应性鼻炎(non-allergic rhinitis)中最常见、最重要、最典型的一个临床类型[1-2].但长期以来,对这一病名存有不少争议.有文献称之为内源性鼻炎(intnnsic rhinitis)[3]、非变应性常年性鼻炎(non-allergic perennial rhinitis)[4]、持续性非变应性鼻炎(persistent non-allergic rhinitis)[5]、非感染性非变应性鼻炎(non-infectious non-allergic rhinitis)或非变应性非感染性常年性鼻炎(non-allergic non-infectious perennial rhinitis)[6].

  9. Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis

    Directory of Open Access Journals (Sweden)

    Janina Grzegorczyk

    2002-01-01

    Full Text Available Background: The goal of our study was to examine spontaneous and stimulated apoptosis of peripheral blood MNC from allergic patients, sensitized to Der p I antigen as compared to cells from non-atopic subjects. Furthermore we aimed to investigate which populations of mononuclear cells (lymphocytes, monocytes undergo the apoptosis and to determine relations between apoptosis and serum levels of sFas/APO-1, ICE/caspase-1 or TNF-α.

  10. The effects of subcutaneous allergen immunotherapy by Alutard SQ allergy vaccination in management of perennial allergic rhinitis%标准化屋尘螨疫苗特异性免疫治疗常年性变应性鼻炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    符微; 林霞; 蔡飞; 王刚; 邓慧林; 黎箐; 王小娟

    2012-01-01

    目的:了解标准化屋尘螨疫苗特异性免疫治疗常年性变应性鼻炎的疗效.方法:对38例变应性鼻炎患者用标准化屋尘螨疫苗特异性免疫治疗3年或3年以上,免疫前后进行症状和体征评分.结果:38例中,显效21例,有效7例,无效10例,总有效率达73.68%.结论:标准化屋尘螨疫苗特异性免疫治疗变应性鼻炎疗效明显.%Objective: To study the effects of subcutaneous allergen immunotherapy by Alutard SQ allergy vaccination in management of perennial allergic rhinitis. Method:Thirty-eight cases of the perennial allergic rhinitis received the subcutaneous allergen immunotherapy by Alutard SQ allergy vaccination for 3 years or more than 3 years. The clinical symptoms and signs were compared before and after treatment. Result:Good result were obtained in 21 of 38 cases, 7 cases effective, and 10 cases ineffective. Total effective rate was 73. 68%. Conclusion: The subcutaneous allergen immunotherapy by Alutard SQ allergy vaccination was very effective for the perennial allergen rhinitis.

  11. Study of clinical immunotherapy in children with allergic asthma and rhinitis%过敏性哮喘和鼻炎患儿的临床免疫治疗研究

    Institute of Scientific and Technical Information of China (English)

    杭杲; 刘春霞

    2014-01-01

    目的:探讨过敏性哮喘和鼻炎患儿的特异性免疫治疗的临床应用。方法采用体外特异性过敏原检测系统对儿童医院门诊患儿进行血清过敏原特异性 lgE(SlgE)抗体和总 lgE 进行检测,对尘螨过敏患儿进行分组治疗,免疫治疗组采用粉尘螨滴剂舌下脱敏治疗,对照组按普通药物抗过敏治疗,治疗6个月、12个月给予临床控制指标评分,同时观察患儿血清中 SIgE 的改变。结果218例过敏患儿吸入性过敏114例(52.4%),食入性过敏101例(46.3%)。98例尘螨过敏患儿占总过敏者和吸入性过敏者的44.95%和85.96%。免疫治疗组与对照组比较差异有统计学意义(P <0.05);脱敏治疗患儿 SIgE 阳性率有所下降,但差异无统计学意义(P >0.05)。结论218例过敏患儿的特异性过敏原检测中尘螨过敏者最多;舌下特异性免疫治疗过敏性哮喘和鼻炎效果显著。%Objective To investigate the clinical application of specific allergen immunotherapy (AIT)for the children with al-lergic asthma and rhinitis.Methods The in vitro specific allergen test system was adopted to detect allergen specific IgE and total IgE in children outpatients of the Children's Hospital.The children patients with dust mite allergy were divided into groups for con-ducting therapy.The immunotherapy group adopted the Dermatophagoides farinae drops for hypoglossis desensitization therapy, while the control group was performed the anti-allergic therapy by the common drugs.The clinical control indicator scores were per-formed after 6-months and 12-month therapy and at the same time the change of serum specific LgE was observed.Results Among 218 cases of allergy,114 cases(52.4%)were inhalation allergy and 101 cases (46.3%)were food allergy.98 cases of dust mite al-lergy accounted for 44.95% of the total allergy and 85.96% of the inhalation allergy.The difference in the curative effects

  12. 共刺激分子OX40/OX40L在小鼠变应性鼻炎发病机制中的作用%Effect of the costimulatory pathway OX40/OX40L on pathogenesis of allergic rhinitis in mice

    Institute of Scientific and Technical Information of China (English)

    李伟; 甘敏; 刘尚耀; 朱凤华; 杜明; 赵建东

    2011-01-01

    目的 探讨OX40/OX40L在小鼠变应性鼻炎发病机制中的可能作用.方法 精选30只清洁级小白鼠,随机分成对照组、模型组、干预组.通过免疫组织化学方法 测定对照组和模型组小鼠鼻黏膜中OX40的表达,同时应用ILISA法测定各组中IL-4、IL-10、IFN-γ的水平.结果 OX40在变应性鼻炎小鼠鼻黏膜上皮细胞、腺体细胞、血管内皮细胞、CD4T细胞中均呈现高表达,OX40主要表达于细胞膜、细胞浆,在对照组中极少表达(P<0.05).ILISA法测定IL-4、IL-10、IFN-γ在对照组与模型组间差异有统计学意义(P<0.05),模型组和干预组相比差异有统计学意义(P<0.05).结论 OX40/OX40L在变应性鼻炎小鼠发病机制中起重要作用.%Objective To evaluate the role of another costimulatory pathway OX40/OX40 ligand(L) in pathogenesis of allergic rhinitis in mice. Methods 30 mice were divided into three groups: the control group, the allergic rhinitis group, and the OX40LmAb interfere group. Immunohistochemistry was used to examine expression of OX40 in the first two groups. IL-4, IL-10 and IFN-γ in the peripheral blood were analyzed by ELISA. Results OX40 showed a strong expression in the epithelium, glandular epithelium cells, vascular endotheliocytes and CD4 + T cells. OX40 was mainly expressed in cytomembrance and cytoplasm, while OX40 was a stained a little in the control group. There was a statistically significant deviation between the allergic rhinitis and control groups ( P <0.05). Compared with the control group, the allergic rhinitis group had higher IL-4 and IL-10 levels and lower IFN-γlevel in peripheral blood (P <0.05). Compared with the allergic rhinitis group, the OX40LmAb interfere group had lower IL-4 level and higher IFN-γlevel in peripheral blood(P <0.05). Conclusion OX40/OX40L plays an important role in pathogenesis of allergic rhinitis in mice.

  13. Establishment of Aats Allergic Rhinitis and Asthma Syndrome Model and Evaluation%过敏性鼻炎-哮喘综合征大鼠模型的建立与评价

    Institute of Scientific and Technical Information of China (English)

    史锁芳; 周奎龙

    2014-01-01

    Objective:To establish a rat model of allergic rhinitis and asthma syndrome and evaluate its effect .Methods:Clean level 20 healthy male SD rats , were randomly divided into control group and model group , 14 days after the use of intraperitoneal injection of ovalbumin, continuous nasal drip with ovalbumin 7 days, starting from 15th, the model group rats in the airtight vessel within (home-made 50 cm ×30 cm ×20 cm transparent plastic box ) with cover , give 2%OVA atomized inhalation solution , build model;In the con-trol group with normal saline instead .Results:The model group after antigen stimulate the mouth breathing , abdominal moved , irrita-bility, restlessness, shaking, hair, nose, sneezing, very oral and ear purple , water quantity increased obviously , listlessness, eat less, unresponsive, activity significantly reduced or prone motionless , the colour yellow curly, such as asthma acute attack.Total num-ber of white blood cells in BALF ( bronchoalveolar lavage ) and classification of eosinophil increased obviously .Nose and a small bron-chus and lung tissue pathology slice see accompanying around blood vessels more inflammatory cells , numerous eosinophils cells infil-trating .Conclusion:The model of allergic rhinitis and asthma syndrome is established by the way in this study , which is comparable to the physiopathologic characteristics of human asthma ., the successful molding method has certain popularization value .%目的:建立一种大鼠过敏性鼻炎-哮喘综合征的模型并评价其效果。方法:清洁级健康雄性SD大鼠20只,随机分为对照组和模型组,运用卵白蛋白腹腔注射14天后,用卵白蛋白连续鼻部滴注7天,从第15日开始,将模型组大鼠置于密闭器皿内(自制的50 cm ×30 cm ×20 cm透明带盖塑料盒),给予2%OVA溶液进行雾化吸入,建立模型;对照组以生理盐水代替。结果:模型组经抗原激发后张口喘息,腹部翕动,易激惹,躁动

  14. Clinical surveys on the incidence of asthma and airway hyper responsiveness in allergic rhinitis%变应性鼻炎患者潜在哮喘和下气道高反应的筛查研究

    Institute of Scientific and Technical Information of China (English)

    刘晓芳; 王向东; 王杨; 赵岩; 孙永昌; 张罗

    2012-01-01

    OBJECTIVE Allergic rhinitis and its impact on asthma (ARIA) questionnaire combined with indices in spirometric test may facilitate early diagnosis for asthma complicating in allergic rhinitis (AR) and for airway hyperresponsiveness (AHR) . METHODS A total of 306 AR patients without diagnosis of asthma received ARIA questionnaire, spirometric test and methacholine challenge test (MCT) to determine the incidence of asthma or AHR. The values corresponding to FEVi% and FEF25-75% were compared and ROC curves were plotted. RESULTS There were 127 cases with more than one positive response in the questionnaire, of which 24 cases showed positive response in pulmonary function diastole test, and 32 cases positive response in MCT. The omission diagnose rate of asthma was 18%, and the incidence of asthma in the cases with positive response was 44.1%. There were 179 cases with no positive response in the questionnaire, of which 41 cases were diagnosed as AHR with the incidence of 13%. The values of FEV1% and FEF25-75% in the different groups with MCT positive responses were significantly lower than those in the group with negative responses. Moreover, the ROC curves demonstrated the diagnostic accuracy of FEF25-75% was slightly higher than that of FEVi% for asthma or AHR. CONCLUSION ARIA questionnaire may help screen the combined asthma in AR. Some AR patients affiliated AHR. Damage in small airway function may prompt occurrence of asthma or AHR, and the related cases should receive MCT.%目的 探讨问卷调查结合肺功能发现变应性鼻炎(AR)合并哮喘和气道高反应性(airway hyperresponsiveness,AHR)的意义.方法 306例无哮喘的AR患者行问卷调查、肺功能乙酰甲胆碱激发试验(methacholine challenge test,MCT),诊断哮喘或AHR.比较第一秒用力呼气容积占预计值的百分比(FEV1%)和用力呼气中段流速(FEF25-75%)值,绘制ROC曲线.结果 127例有哮喘症状,24例肺功能舒张试验阳性,32

  15. Three minus septoplasty combined with radiofrequency ablation for perennial allergic rhinitis%三线减张鼻中隔矫正联合射频消融治疗持续性变应性鼻炎

    Institute of Scientific and Technical Information of China (English)

    张萍; 耿江桥; 刘原虎; 韩书婧; 倪鑫; 许尧生; 葛文彤

    2015-01-01

    目的 探讨三线减张鼻中隔矫正联合低温等离子射频消融治疗伴有鼻中隔偏曲的中-重度持续性变应性鼻炎(persistent allergic rhinitis,PAR)的疗效.方法 分别采用三线减张鼻中隔矫正术(对照组32例)和三线减张鼻中隔矫正联合低温等离子射频消融(观察组36例)治疗伴有鼻中隔偏曲的PAR,术后随访1年,根据症状和体征记分评定其疗效:≥66%为显效,65% ~26%为有效,≤25%为无效.结果 对照组总有效率59.4%,观察组总有效率91.7%.观察组总有效率显著高于对照组(P<0.05).结论 对伴有鼻中隔偏曲的PAR,三线减张鼻中隔矫正联合低温等离子射频消融治疗PAR的疗效明显优于单纯三线减张鼻中隔矫正术.

  16. 高强度聚焦超声治疗变应性鼻炎远期疗效的临床研究%Clinical research of long-term efficacy of high intensity focused ultrasound in treating allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    易兴梅; 罗小娟

    2014-01-01

    Objective To observe the long-term efficacy of nasal endoscopy-guided high intensity focused ultrasound (HIFU ) in the treatment of allergic rhinitis .Methods 300 patients with allergic rhinitis who failed in medication were randomly divided into the treatment group(n=162) and the control group(n=138) .The patients in the treatment group were accepted the nasal endosco-py-guided HIFU therapy ,while the patients in the control group were subjected to the hypothermy plasma ablation .The two groups were followed up after operation ,and the visual analogue scale(VAS) was employed to evaluate the therapeutic efficacy at postoper-ative 3 ,6 ,12 ,24 months .The saccharin tests were performed at the beginning and ending of treatment to assess the nasal mucocili-ary function in the patients of the two groups who voluntarily accepted the functional test of nasal cilia .Results After 2-week treat-ment ,nasal congestion ,sneezing ,runny nose ,nasal itching and other symptoms in the two groups were significantly relieved with no obvious complication .2-year follow-up demonstrated that the total effective rate in the treatment group was 61 .4% ,which was markedly higher than 50 .7% in the control group(P=0 .017) .The average saccharin clearance time of the treatment group (n=49) and the control group(n=39) were(464 ± 152)s and(738 ± 149)s ,respectively ,and their difference was statistical significant (P=0 .026) .Conclusion The long-term efficacy of HIFU treatment in allergic rhinitis is superior to that of hypothermy plasma abla-tion ,possesses less impacts on the nasal mucociliary function ,and is worthy of clinical promotion .%目的:观察鼻内窥镜下高强度聚焦超声(HIFU)治疗变应性鼻炎的远期疗效。方法将300例药物治疗无效的变应性鼻炎患者分为治疗组(n=162)及对照组(n=138)。治疗组患者在鼻内窥镜下进行HIFU治疗,对照组患者进行低温等离子消融治疗。两组患者术后随访,采用视

  17. 变应性鼻炎患者3292例变应原谱变化分析%Analysis of allergen variation for 3292 patients with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    彭晓林; 张金梅; 王丽生; 时文杰; 孙沛湧; 张玉庚; 林鹏

    2013-01-01

    Objective To investigate the variation of common allergens in patients with allergic rhinitis in recent 4 years in Tianjin First Center Hospital.Methods The medical records of skin prick test on 3292 patients with allergic rhinitis between 2009 and 2012 were restrospectively analyzed.The changing trend of various allergens in 4 years and distribution differences were compared.The differences of the top 5 allergens in under age group,adult group and different gender group were further analyzed by SPSS 19.0 software.Results The positive rate of dermatophagoides farinae was increasing year by year,from 45.1% in 2009 to 66.3% in 2012,and the positive rate of dermatophagoides pteronyssinus increased from 42.0% in 2009 to 58.6% in 2012,the difference was statistically significant (x2 value was 68.70,41.55,all P <0.01).The positive rate of dermatophagoides farinae and dermatophagoides pteronyssinus in adult group and male group showed significant upward trend year by year (x2 value was 75.85,69.93,274.25,42.62,all P <0.01),but not in adult group and female group.The positive rate of quinoa,mugwort and humulus scandens decreased year by year between 2009 and 2011 (x2 value was 22.08,11.64,203.19,all P <0.01),but increased again in 2012 (x2 value was 21.55,29.38,12.40,all P < 0.01).Conclusions There is a tendency of change of allergens in patients with AR.This phenominon may be helpful for doctors to choose the type of skin prick liquid.%目的 了解天津市第一中心医院近4年来变应性鼻炎(allergic rhinitis,AR)患者变应原谱的变化情况.方法 回顾性分析2009-2012年确诊为AR的3292例患者皮肤点刺试验结果,研究各变应原阳性率4年来的变化趋势,并进一步分析前5位变应原在未成年人组、成年人组以及不同性别组的变化情况,以SPSS 19.0软件对数据进行统计学分析.结果 粉尘螨、屋尘螨变应原阳性率呈逐年增高趋势,分别由2009年的45.1%、42.0%上升至2012

  18. Analysis of efficacy and safety of standardized dust mites allergen vaccine in treatment of allergic rhinitis%标准化尘螨变应原治疗变应性鼻炎的疗效及安全性分析

    Institute of Scientific and Technical Information of China (English)

    桂晓钟; 纪东; 程静; 赵军; 王林; 蒋传亚

    2012-01-01

    目的 观察分析标准化尘螨变应原皮下注射治疗常年性变应性鼻炎的疗效及安全性.方法 对175 例尘螨过敏的变应性鼻炎患者进行标准化尘螨变应原皮下注射治疗,比较接受免疫治疗前与剂量累加阶段、剂量维持阶段的鼻部症状评分、体征评分和不良反应情况,分析评价特异性免疫治疗的疗效及安全性.结果 175例尘螨过敏的变应性鼻炎患者的鼻部症状与治疗前相比有明显减轻,差异有统计学意义(P﹤0.05);剂量累加阶段和剂量维持阶段的总有效率分别为84.57%和95.43%,单一尘螨过敏较以尘螨过敏为主的多种过敏原病例疗效较好,单一尘螨过敏显效的占全部病例的78.38%;多种过敏原过敏显效的占全部病例的40.38%.本组病例均未出现严重不良反应.结论 对尘螨引起的常年性变应性鼻炎进行规范化标准化变应原特异性免疫皮下注射治疗,是一种有效、安全和持久的对因治疗方法,并可有效控制哮喘症状.%Objective To observe and analyse the therapeutic effects and the safety of standard subcutaneous immuno - theraphy on the patients with perennial allergic rhinitis. Methods One hundred and seventy - five patients with allergic rhinitis caused by house - dust mites were selected. Clinical efficacy was evaluated by symptom and sign score after two stages of specific immunotherapy and compared with pre - treatment scores. Results The main symptoms of allergic rhinitis were significantly alleviated in those treated with standardized dust mites compared with those untreated. The difference was statistically significant ( P < 0.05 ). The effective rates were 84. 57% after the first phases of the SIT and 95. 43% after the second phases. Clinical efficacy on the house - dust mite allergic rhinitis patients was better than multi - allergen rhinitis patients. No serious complications or bad reaction were found in the treatment process. The treatment efficacy

  19. Epidemiological investigation and analysis of allergic rhinitis in troops stationed in Xuzhou%驻徐部队变应性鼻炎流行病学调查及分析

    Institute of Scientific and Technical Information of China (English)

    燕志强; 单兵; 许保健; 王少会; 王青; 高盛宏; 洪锦科

    2012-01-01

    Objective To investigate the epidemiology of allergic rhinitis (AR) in troops stationed in Xuzhou, and to analyze its associated risk factors and influence on sleep patterns, life quality, and training of officers and soldiers. Methods A randomly chosen sample of 1030 servicemen stationed in Xuzhou from March to April 2011 served as the subjects of this study. The study was conducted in two phases: first, a questionnaire survey was undertaken. Those suspected to have AR, discovered through the questionnaire results, were finally diagnosed by clinical examination. Results Up to 1052 questionnaires were issued, among which 1030 questionnaires were deemed valid. The overall incidence of AR in troops stationed in Xuzhou was 17.1%. The incidence in male and female was 17.0% and 18.8%, respectively, and there was no significant difference (P=0.73l). Bronchial asthma and other allergic diseases, along with family history, were closely related to the occurrence of AR. Therefore they were identified to be the important risk factors for AR (OR=0.967, P=0.001; OR=2.098, P<0.00l). Approximately 44.9% of the patients felt that AR affected their sleep, whereas 75.6% felt the condition affected their life quality and training. Conclusions There is a higher prevalence of AR in troops stationed in Xuzhou. Family history, other allergic diseases are found to be related to increased risk of affection of AR, and there is a significant impact on quality of life, training and rest of soldiers. Reasonable control of AR has important military implication and significance.%目的 调查驻徐部队变应性鼻炎(AR)的流行病学特征,分析其相关危险因素及对官兵睡眠、生活及训练的影响.方法 2011年3-4月,随机整群抽取驻徐部队官兵1030人为研究对象,设计调查问卷.调查分两阶段,首先进行问卷调查,然后对根据问卷结果筛选出的AR可疑对象进行临床检查予以确诊.结果 共发放问卷1052份,回收有效问卷1030份.

  20. Home environment, lifestyles behaviors, and rhinitis in childhood.

    Science.gov (United States)

    Wang, Xueying; Liu, Wei; Hu, Yu; Zou, Zhijun; Shen, Li; Huang, Chen

    2016-03-01

    The prevalence of children allergic rhinitis has been increasing in China and associated factors still are not clear. In the present paper, we selected 13,335 parent-reported questionnaires of 4-6 years-old children, in a cross-sectional study from April 2011 to April 2012 in Shanghai city, and investigated associations of various factors with parent-reported allergic rhinitis (doctor-diagnosed) and rhinitis symptoms in childhood. After adjusted by age, sex, family history of atopy, and respondent of questionnaire, we find that no siblings, mother in older age during pregnancy, shorter breastfeeding, using antibiotics in the first year, and home dampness-related exposures, had significant associations with increased prevalence of the studied diseases. Location, type, building area, decoration materials and construction period of the residence, also had significant associations with these diseases. Current parental smoking and pet-keeping had no significant associations with the studied diseases. Incense-burning and using mosquito coils had significant associations with reduced risk of allergic rhinitis and with increased risk of rhinitis symptoms. Using air cleaner and cleaning the residence in high frequency had associations with increased risk, but eating fast food and ice cream often had associations with the reduced risk, of the studied diseases. Families with children being diagnosed allergic rhinitis likely change their lifestyle behaviors. In conclusion, childhood rhinitis could be influenced by heredity and many "environmental exposures". Avoidance behaviors and reverse causation in parental smoking, pet-keeping, and dietary habits for childhood rhinitis should be carefully considered. PMID:26712524

  1. The Treatment of Allergic Respiratory Disease During Pregnancy.

    Science.gov (United States)

    Namazy, Jai; Schatz, M

    2016-01-01

    Pregnancy may be complicated by new-onset or preexisting asthma and allergic rhinitis.This article reviews the recognition and management of asthma and allergic rhinitis during pregnancy, paying close attention to the general principles of allergy and use of asthma medication during pregnancy. Both allergic rhinitis and asthma can adversely affect both maternal quality of life and, in the case of maternal asthma, perinatal outcomes. Optimal management is thus important for both mother and baby. This article reviews the safety of asthma and allergy medications commonly used during pregnancy.

  2. 寒、热证豚鼠变应性鼻炎细胞功能及形态学观察%Functional and Morphological Observation on Cells in Allergic Rhinitis Guinea- Pigs with Cold or Heat Syndrome

    Institute of Scientific and Technical Information of China (English)

    周小军; 安辉; 田道法; 唐发清; 曾庆善; 蒙旭光; 文志

    2001-01-01

    目的:研究寒证及热证豚鼠变应性鼻炎(AR)细胞功能和形态学特征。方法:以寒性、热性中药分别给予豚鼠造成寒证、热证模型,然后以甲苯二异氰酸酯和盐酸萘甲唑啉点鼻,分别造成AR和鼻炎模型,观察其细胞功能、数量及电镜下超微形态学特点。结果:AR模型豚鼠血嗜碱性粒细胞(BC)脱颗粒指数高于鼻炎模型豚鼠;其中寒证AR豚鼠又高于热证AR豚鼠(P<0.05)。寒证AR豚鼠鼻粘膜肥大细胞(MC)及嗜酸性粒细胞(EC)数量多,浸润广泛,颗粒包膜不清,密度不均,颗粒内见空泡、融合及管道;而热证AR豚鼠及对照组豚鼠MC及EC数量少,无浸润,颗粒包膜清,密度均一,无颗粒空泡、融合及管道。结论:寒证AR豚鼠BC、MC、EC呈明显活化状态。%Objective: To investigate the functional and morphologicalcharacteristics of cells in allergic rhinitis (AR) guinea-pigs with Cold or Heat Syndrome. Methods: The Cold Syndrome or Heat Syndrome guinea-pig model was made, and then reformed into AR model or rhinitis medicamentosa (RM) model by using nose drops of 10% toluene di-isocyanate (TDI) or 0.1% naphazoline hydrochloride. The cell function, count and ultramicroscopic morphology characteristics in the model animals were observed. Results: The degranulation index (DI) of blood basophils and the count of mast cells (MC) in nasal mucosa were higher in AR guinea-pigs with Cold Syndrome than that in Heat Syndrome guinea-pigs, but the two parameters in AR with both Cold and Heat Syndrome were higher than those in the RM model. Mast cell and eosinophilic granulocyte in AR guinea-pigs with Cold Syndrome were high in count, widely infiltrated, indiscernible cellular capsule, heterogeneous in density, and vacuoles, fusions and tubules in granules while in those with Heat Syndrome, mast cells and eosinophils were scarcely found, without infiltration, granules with discernible membrane and homogeneous in

  3. Effect of allergic rhinitis on adult obstructive sleep apnea hypopnea syndrome%变应性鼻炎对成人阻塞性睡眠呼吸暂停低通气综合征的影响

    Institute of Scientific and Technical Information of China (English)

    张立坤; 邵东风; 谷彬; 梁振; 李海春; 王东海

    2015-01-01

    目的:探讨变应性鼻炎(allergic rhinitis,AR)对成人阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的影响。方法筛选同时患有持续性AR及OSAHS(除外中枢性OSAHS)成人(年龄>18岁)共120例,进行血清IgE、变应原检测,鼻内镜、多导睡眠监测(polysomnography,PSG)检查,比较患者系统抗过敏治疗前后鼻部症状评分、呼吸暂停低通气指数(apnea hypopnea index,AHI)、最低血氧饱和度(lowest oxygen saturation,LSaO2)、鼾声指数和嗜睡程度(epworth sleepiness scale,ESS)。结果持续性AR伴有轻度OSAHS患者经正规抗过敏治后AHI、LSaO2、ESS评分及鼾声指数分别为(7.74±0.62)次/h、(89.00±0.71)%、6.80±0.59、97.47±13.64,与治疗前(10.68±0.94)次/h、(81.10±0.46)%,8.82±0.66、131.48±19.23相比有显著改善(P<0.05)。持续性AR伴有中度OSAHS患者经正规抗过敏治疗后AHI、LSaO2、、ESS评分及鼾声指数分别为(15.53±1.83)次/h、(79.00±1.65)%、9.26±0.39、187.42±28.26,与治疗前(21.73±2.78)次/h、(70.60±1.77)%,13.53±1.78、234.39±33.79相比有显著改善(P<0.05)。持续性AR伴有重度OSAHS患者经抗过敏治疗后ESS评分由20.29±1.57降至14.47±1.04(P=0.037);鼾声指数由治疗前367.96±47.25降至252.54±36.47(P=0.029)。结论持续性AR伴OSAHS患者经过系统抗过敏治疗后鼻部症状明显改善;AR可加重OSAHS低通气及呼吸暂停次数,影响患者血氧饱和度,加重其白天嗜睡症状。%Objective To investigate the effects of allergic rhinitis (AR) on obstructive sleep apnea hypopnea syndrome (OSAHS) in adult. Methods One hundred and twenty adult patients (>18 years) with allergic rhinitis and OSAHS were selected. Serum IgE, allergen detection, nasal endoscope, and multi-guided sleep monitoring (PSG) were performed. The anti-allergy treatment of all patients, sleeping parameters including apnea hypopnea index (AHI), snoring

  4. Halting the allergic march.

    Science.gov (United States)

    Van Bever, Hugo P; Samuel, Sudesh T; Lee, Bee Wah

    2008-04-01

    The prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact environmental causes for the increase of allergic diseases have not yet been identified, but most researchers agree that a decreased bacterial load in young children may be one of the reasons for the increase. However, the causes of allergy are multiple, and the development of an allergic disease is the result of complex interactions between genetic constitution and environmental factors. In this review article, different aspects of allergic sensitization are covered, including prenatal and postnatal sensitization. The phenomenon of the "allergic march" (switching from one clinical expression of allergy to another) and its underlying mechanisms are discussed. The last part of this review article is on prevention and treatment of allergic diseases, including the role of bacterial products (probiotics, prebiotics, and synbiotics) and the role of immunotherapy, including sublingual immunotherapy. PMID:23283392

  5. Analysis of HLA-DRB1,DQB1 polymorphism in Uyghur and Han patients with allergic rhinitis in Xinjiang%新疆维吾尔、汉族变应性鼻炎患者 HLA-DRB1、HLA-DQB1基因多态性分析

    Institute of Scientific and Technical Information of China (English)

    崔忠涛; 范宇琴; 胡斌; 阳玉萍; 张华

    2015-01-01

    Objective To investigate the association between HLA-DRB,DQB1 alleles and artemisia pollen allergic in Han and Uyghur patients of people in Xinjiang.Methods By using PCR-SSP (sequence-specific primer polymerase chain reaction),we tested HLA-DRB,DQB1 alleles in fifty Uyghur and fifty Han peo-ple with artemisia pollen allergic rhinitis in Xinjiang.The control group included fifty Uyghur and fifty Han people in the region.Results The statistical results showed that the frequencies of HLA-DRB1*01 were significantly higher in the Uyghur group with allegic rhinitis(9%)than in the control group(1%)(P<0.05)and the frequencies of HLA-DQB1*05 were significantly higher in the Uyghur group with allegic rhinitis(19.4%)than in the control group(7%)(P < 0.05).The frequencies of HLA-DRB1 * 11 were higher in the Han group with allergic rhinitis(9%)than in the control group (2%)(P <0.05).The other alleles frequencies had no significant difference in the allergic rhinitis group and in the control group.Con-clusion The investigation indicated that HLA-DRB1*01,HLA-DQB1*05 might be the inducing factors.%目的:研究新疆地区维吾尔,汉族蒿属花粉变应性鼻炎(Allergic rhinitis,AR)患者 HLA-DRB1、HLA-DQB1等位基因与蒿属过敏易感性的关系。方法采用聚合酶链反应-序列特异性引物技术(PCR-SSP)对新疆地区50名维吾尔族和50名汉族蒿属花粉变应性鼻炎患者及随机选取的本地区的50名维吾尔族和50名汉族健康人(对照组)的 HLA-DRB1、HLA-DQB1等位基因进行检测。结果维吾尔族变应性鼻炎组患者的 HLA-DRB1*01基因频率(9%)明显高于对照组(1%),差异有统计学意义(P <0.05),HLA-DQB1*05基因频率(19.4%)明显高于对照组(7%);汉族变应性鼻炎组患者的 HLA-DRB1*11基因频率(9%)明显高于对照组(2%),差异有统计学意义。HLA-DQB1等位基因频率与对照组差异无统计学意义。结论 HLA-DRB1*01

  6. Out-of-season recollection of drug use for seasonal IgE-mediated rhinitis

    DEFF Research Database (Denmark)

    Bodtger, Uffe; Malling, Hans-Jørgen; Poulsen, Lars K.

    2005-01-01

    The history of seasonal, IgE-mediated (allergic) rhinitis is often obtained postseasonally as a retrospective assessment. It is not known whether recollected drug use is representative for the in-seasonal medication history....

  7. Co-Administration of Chenopodium Album Allergens and CpG Oligodeoxy-nucleotides Effects on Peripheral Blood Mononuclear Cells of Patients with Allergic Rhinitis Treated with Intranasal Corticosteroids

    Directory of Open Access Journals (Sweden)

    Shokrollah Farrokhi

    2011-06-01

    Full Text Available Allergic Rhinitis (AR is one of the most common chronic diseases in the developed countries. This study was performed to investigate the effect of CpG-ODN in alteration of T-helper (Th1/Th2 balance of patients with AR treated with intranasal corticosteroids (INCs and antihistamines. Peripheral blood mononuclear cells (PBMCs of 20 patients with AR were isolated before and after 45 days therapy.Cytokine production (IL-4, IL-10, IL-13, IFN-γ and specific Ch.a IgE in response to CpG co- administration  of  natural  chenopodium  album  (CpG/Ch.a  or  recombinant  Ch.a  (CpG/rCh.a allergen were investigated in supernatants.of cultured PBMCs using ELISA Intracellular IL-10 was also assessed in CD4+ cells using flow cytometry. Significant increase in production of IFN-γ and IL-10 and decrease in production of IL-4 were found in supernatants of cultured PBMCs activated with CPG/ch.a and CPG/rch.a. of both CpG/Ch.a and CpG/rCh.a compared to allergens alone, before and after therapy.After therapy, IFN-γ production with CpG/Ch.a was significantly increased in comparison with before (237 vs. 44 pg/ml, p=0.001. IFN-γ and IL-10 production with CpG/rCh.a was significantly increased after therapy compared to before (407.6 vs. 109 pg/ml, p=0.01 for IFN-γ; 171.7 vs. 52.6 pg/ml, p=0.008  for  IL-10,  whilst  IL-4  was  significantly decreased (2.1  vs.  5.8  pg/ml,  p=0.02. Intracellular IL-10 expression was also significantly increased in response to either CpG/Ch.a or CpG/rCh.a that showed intracellular assay could be more sensitive than ELISA. Also, treatment with intranasal corticosteroids and antihistamines could enhance this CpG effect, in vitro.

  8. Association between the Interaction of Key Genes Involved in Effector T-Cell Pathways and Susceptibility to Develop allergic Rhinitis: A Population-Based Case-Control Association Study.

    Directory of Open Access Journals (Sweden)

    Yuan Zhang

    Full Text Available Evidence suggests that interaction between key genes mediating signaling and transcriptional networks involving effector T-cell responses may influence an individual's susceptibility to develop allergic rhinitis(AR.The aim of this study was todetermine whether specific interactions between key genes involved in effector T-cell pathways are associated with an individual's susceptibility to develop AR in Han Chinese subjects.A cohort of 489 patients with AR and 421 healthy controls was enrolled from the Han Chinese population in Beijing, China. AR was established by questionnaire and clinical examination, and peripheral blood was drawn from all subjects for DNA extraction. A total of 96 single nucleotide polymorphisms (SNPs in 26 reprehensive candidate genes involved in T helper 1 (Th1, Th2, Th17, Th9 and T regulatory cell pathways were selected from the International Haplotype Mappingdatabase for Han Chinese in Beijing (CHB population, and IlluminaGoldenGate assay was conducted for SNP genotyping. The PLINK software package was used to perform statistical analyses.Simple SNP-phenotype association analysis using logistic regression showed SNP rs8193036 in IL17A gene, rs2569254 in IL-12 and rs1898413 in RORα weresignificantlyassociatedwith AR.Simple SNP-phenotype association analysis with genetic models demonstrated thatrs2569254 in IL-12, rs1031508 in STAT4, and rs3741809 in IL-26 were likely to be recessive, rs8193036 in IL17A allelic, rs897200in STAT4 genotypic, and rs1898413 in RORα dominant. Epistasis analyses exhibited that 83 SNPs in 23 genes were significantly interactive; of which 59 interactions/SNP pairs demonstrated OR values higher than 2 or lower than 0.5, and 12 interactions/SNP pairs OR values higher than 4 or lower than 0.25. STAT3, RORα and IL-26, involved in Th17 pathway,were the mostfrequentlyinteractive genes.This study suggests that interactions between several SNPs in key genes involved in effector T-cell pathways are

  9. 低温等离子消融治疗持续性变应性鼻炎回顾分析%Retrospective analysis of low-temperature plasma ablation therapy on persistent allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    刘智献; 李晓晖

    2012-01-01

    目的 探讨低温等离子消融及YAG激光联合鼻中隔矫正术治疗持续性变应性鼻炎(PAR)的疗效,寻求治疗PAR的辅助手术方法.方法 随访随机分组治疗后3年的患者,其中低温等离子消融组127例,YAG激光组118例.应用视觉模拟量表(VAS)对患者鼻塞、流鼻水、喷嚏、鼻痒、眼痒等症状进行术前和术后3年评分,比较两组治疗前后和两组之间疗效.结果 低温等离子消融组有效率87.4%,YAG激光组有效率为66.1%,差异有统计学意义(x2=15.74,P<0.01).两组术后VAS评分差异均有统计学意义(t=21.24、20.56,均P<0.01).结论 低温等离子消融治疗PAR明显优于YAG激光,可作为治疗PAR辅助方法之一,且安全性高.%Objective To compare the effect of low-temperature plasma ablation and YAG laser treatment on persistent allergic rhinitis(PAR) after septoplasty and to seek adjunct surgical procedures to tackle PAR.Methods Follow-up was performed three years after randomized grouping on PAR patients ( Low-temperature plasma ablation group 127 cases and YAG laser group 1 18 cases).Visual Analog Scale (VAS) was used to evaluate symptoms,such as nasal congestion,running nose,sneezing,nasal itching,eye itching etc preoperatively and postoperatively in order to compare the treatment effectiveness and intergroup difference.Results The efficacy rate of Low-temperature plasma ablation group was 87.4%,and YAG laser group was 66.1%.The difference was statistically significant( x2 =15.74,P < 0.01 ).The VAS scores for postoperative symptom relief in both groups were significantly different ( t =21.24,20.56,all P < 0.0 1 ).Conclusion As an adjunct treatment approach,low-temperature plasma ablation was superior to YAG laser in the treatment of PAR with preferable safety.

  10. Interaction between rhinitis and asthma: state of the art.

    Science.gov (United States)

    Frieri, Marianne

    2003-01-01

    Rhinitis and asthma are very prevalent allergic disorders with comorbid features, similar risk factors, and environmental triggers. Pathophysiological processes are linked via tissue histopathology, immunologic pathway, and inflammatory mediators. Allergen challenge of the upper airway can increase lower-airway responsiveness and allergen challenge of the lower airway can lead to upper-airway inflammation. Both allergic rhinitis and asthma exert a high social and economic burden in significant loss of work and school days as well as impairment for children and adults. PMID:14763239

  11. Lactobacillus on allergic rhinitis rat models of the influence of the immune function *%乳酸杆菌对过敏性鼻炎模型大鼠免疫功能的影响

    Institute of Scientific and Technical Information of China (English)

    胡晓艳; 姜梁

    2013-01-01

      目的探讨乳酸杆菌对过敏性鼻炎(AR)大鼠血清中IL-4、IL-5、IFN-γ水平等免疫指标的影响。方法 SD大鼠60只随机分为正常对照组、模型组、乳酸杆菌组及阳性药对照组共4组,每组10只。乳酸杆菌组每天用乳酸杆菌活菌制剂灌胃3周;建立大鼠卵清蛋白致敏模型;阳性药对照组灌胃氯雷他定;另外20只大鼠用于被动皮肤过敏试验(PCA ),检验大鼠模型制备及治疗情况;测定实验各组大鼠血清IL-4、IL-5、IFN-γ水平,检测鼻分泌物中嗜酸性粒细胞(EOS )水平。结果模型组IL-4、IL-5水平显著高于正常对照组(P<0.05),IFN-γ水平降低,低于正常对照组(P<0.05)。乳酸杆菌组IL-4、IL-5水平均显著低于模型组(P<0.05),IFN-γ水平增加,高于模型组(P<0.05)。乳酸杆菌组各项指标与阳性药对照组比较差异无统计学意义(P>0.05)。结论乳酸杆菌可下调AR大鼠血清中IL-4、IL-5水平,上调IFN-γ水平,调节Th1/Th2淋巴细胞亚群平衡,减轻鼻黏膜变应性炎症。%Objective Explore the effect lactobacillus on allergic rhinitis (AR) rat serum Il-4 ,Il-5 ,IFN-γ concentration and the influence of immune markers .Methods SD rat 60 were randomly divided into 4 groups ,each group of 10 only .Lactic acid bacteria group every day with lactobacillus living bacterium preparations irrigation stomach 3 weeks ,establish rats LuanBai protein sensitiza-tion model ,positive drug control group irrigation stomach loratadine ;Another 20 rats used for passive cutaneous anaphylaxis (PCA) ,inspection in the rat model preparation and treatment .Determination test group rats serum IL-4 ,IL-5 ,IFN-γ,the content of Eos in nasal secretion was detection .Results Model group IL-4 ,IL-5 content was significantly higher than normal control group (P<0 .05) ,IFN-γlevels were low ,lower than the normal control group(P<0 .05) .Lactic acid bacteria

  12. Anthropogenic Climate Change and Allergic Diseases

    Directory of Open Access Journals (Sweden)

    Hueiwang Anna Jeng

    2012-02-01

    Full Text Available Climate change is expected to have an impact on various aspects of health, including mucosal areas involved in allergic inflammatory disorders that include asthma, allergic rhinitis, allergic conjunctivitis and anaphylaxis. The evidence that links climate change to the exacerbation and the development of allergic disease is increasing and appears to be linked to changes in pollen seasons (duration, onset and intensity and changes in allergen content of plants and their pollen as it relates to increased sensitization, allergenicity and exacerbations of allergic airway disease. This has significant implications for air quality and for the global food supply.

  13. Expression of Specific MicroRNA-135a in Nasal Mucosa of Allergic Rhinitis Mice%特异性microRNA-135a在变应性鼻炎小鼠鼻黏膜中的表达

    Institute of Scientific and Technical Information of China (English)

    罗燕云; 邓玉琴; 陶泽璋

    2012-01-01

    目的 研究特异性microRNA-135a(miR-135a)在变应性鼻炎(allergic rhinitis,AR)小鼠鼻黏膜中的表达,探讨其对AR的免疫调控作用.方法 采用卵清蛋白(ovalbumin,OVA)腹腔注射及滴鼻建立AR的小鼠模型,以叠加法进行行为学评分,酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测血清中特异性OVA-sIgE浓度,SYBR Green实时荧光定量逆转录聚合酶链反应(real-time quantitative reverse transcription polymerase chain reaction,qRT-PCR)检测AR小鼠鼻黏膜中转录因子(T-box expressed in T cells,T-bet; GATA binding protein 3,GATA-3)和细胞因子(interferon gamma,IFN-γ; interleukin 4,IL-4)的mRNA表达,以生理盐水组小鼠为对照,确认造模成功.应用Bulge-LoopTM qRT-PCR检测小鼠鼻黏膜中特异性miR-135a表达.结果 叠加法记录AR组小鼠挠鼻(鼻痒)、喷嚏、清涕的行为学评分,总分均超过5分,对照组小鼠均低于5分;AR组小鼠的血清中OVA-sIgE浓度高于对照组,鼻黏膜中T-bet和IFN-γ的mRNA表达低于对照组,而GATA-3和IL-4的mRNA表达高于对照组,其差异均有统计学意义.AR组小鼠鼻黏膜中特异性miR-135a表达低于对照组,差异有统计学意义.结论 AR小鼠鼻黏膜中特异性miR-135a低表达可能通过其靶点GATA-3的mRNA高表达在辅助性T淋巴细胞(T helper cell,Th)亚群Th2细胞的极性分化中发挥重要作用,对导致AR的Th1/Th2失衡机制产生重要的免疫调控作用.%Objective To study the expression of specific microRNA-135a (miR-135a) in nasal mucosa of allergic rhinitis (AR) mice and research the immune regulation of miR-135a on AR. Methods AR mouse model was established by ovalbumin (OVA) peritoneal injection and nasal drop, and the control group by normal saline. The mice were ethologi-cally evaluated by addition method. Specific serum OVA-sIgE concentration was detected by enzyme-linked immunosor-bent assay (ELISA) method, Relative mRNA expressions of transcription factor (T

  14. 鼻用抗组胺药物治疗变应性鼻炎的Meta分析%Efficacy of intranasal antihistamine in the treatment of allergic rhinitis: a meta-analysis

    Institute of Scientific and Technical Information of China (English)

    冯韶燕; 邓春涛; 李磊; 廖伟; 樊韵平; 许庚; 李华斌

    2014-01-01

    Objective To systematically evaluate the efficacy of intranasal antihistamine in the treatment of allergic rhinitis.Methods The randomized controlled trials (RCT) about intranasal antihistamines for the treatment of allergic rhinitis between January 1985 and January 2014 were searched in OVID,PubMed,EMBASE,CNKI,WanFang Data and Cochrane Library.Two reviewers independently screened the literatures,extracted the data,and evaluated the methodological quality,then meta-analysis was performed by using RevMan 5.1 software.Results A total of thirteen RCTs were included.The results of meta-analysis showed that the efficacy of intranasal antihistamine group was superior to the placebo group in total nasal symptom scores (TNSS),the difference was significant [WMD =-1.96,95% CI (-2.06; -1.85),P < 0.01],and individual nasal symptom scores (blocked nose,rhinorrhea,and sneezing)[WMD=-0.18,95%CI (-0.28;-0.08); WMD=-0.45,95%CI (-0.52;-0.38) ;WMD=-0.41,95% CI (-0.58 ;-0.24),all P < 0.01],with significant differences.There was no significant difference between the intranasal antihistamine group and the corticosteroid group in TNSS [WMD =-1.51,95% CI (-3.51; 0.49),P =0.14],but the intranasal antihistamines group was superior to the corticosteroid group in individual nasal symptom scores (blocked nose,rhinorrhea,and sneezing) [WMD =-0.23,95% CI (-0.40;-0.06) ; WMD =-0.35,95% CI (-0.65 ;-0.05) ; WMD =-0.25,95% CI (-0.42;-0.08),all P < 0.05],with significant differences.The intranasal antihistamine group was superior to the oral antihistamines group in TNSS [WMD =-0.88,95% CI (-1.51 ;-0.25),P < 0.01].Conclusion Intranasal antihistamine is effective in the control of nasal symptoms in AR patients.%目的 系统评价鼻用抗组胺药物治疗变应性鼻炎(AR)的临床疗效,为优化AR药物治疗提供循证参考.方法 计算机检索OVID、PubMed、EMBASE和Cochrane Librar、中国学术期刊全文数据库、万方数据库,检索时间为1985年1

  15. Efficacy Observation on Chinese Medicine Atomization Inhalation and Oral Administration Combined with Acupuncture Treating Allergic Rhinitis%中药雾化吸入并内服联合针刺治疗过敏性鼻炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    徐艳

    2016-01-01

    Objective:To investigate the clinical effect of Chinese medicine atomization inhalation and oral administration combined with acupunc-ture treating allergic rhinitis. Methods:162 patients with allergic rhinitis were randomly divided into treatment group (81 cases) and control group (81 cases), both with astemizole (10mg, bid), nitrofurazone and ephedrine nasal drops (2 drops, bid) and routine treatment, treatment group added Chinese medicine atomization inhalation and oral administration combined with acupuncture, to observe the clinical efficacy of the two groups. Re-sults:The total effective rate of treatment group was 95.06%, significantly higher than that of the control group by 75.31%(P<0.05);the improve-ments of clinical symptoms and signs score in treatment group was significantly better than those in control group (P<0.05). Conclusion:Chinese medicine atomization inhalation and oral administration combined with acupuncture treating allergic rhinitis can effectively relieve clinical symp-toms and signs, and improve the life quality, being worthy of clinical application.%目的:探讨中药雾化吸入并内服联合针刺治疗过敏性鼻炎的疗效。方法:将162例过敏性鼻炎患者随机分为治疗组(81例)和对照组(81例),均给予服用息斯敏(10mg/次,bid)、呋麻滴鼻剂滴鼻(2滴/次,bid)等常规治疗治疗,治疗组则在常规治疗基础上给予中药雾化吸入并内服联合针刺治疗,观察两组临床疗效。结果:治疗组总有效率为95.06%,显著高于对照组的75.31%(P<0.05);治疗后,治疗组临床症状体征积分改善程度显著优于对照组(P<0.05)。结论:中药雾化吸入并内服联合针刺治疗过敏性鼻炎可有效缓解临床症状、体征,提高生活质量,值得临床推广应用。

  16. 布地奈德鼻喷雾剂和西替利嗪片联合治疗变应性鼻炎临床观察%Joint clinical observation of the treatment of allergic rhinitis budesonide nasal spray and cetirizine Cinnarizine tablets

    Institute of Scientific and Technical Information of China (English)

    王革; 钟渠; 郑桃晓

    2012-01-01

    目的 探讨布地奈德鼻喷雾剂联合西替利嗪片治疗变应性鼻炎的临床效果.方法 选取71例变应性鼻炎患者随机分为观察组36例与对照组35例,观察组患者采用布地奈德鼻喷雾剂联合西替利嗪片进行治疗,对照组患者采用单纯的布地奈德鼻喷雾剂治疗,对两组患者的治疗过程进行观察,并记录所得数据.结果 观察组36例患者中,显效20例,好转13例,无效3例,治疗有效率为91.7%;对照组35例患者中,显效15例,好转10例,无效10例,治疗有效率为71.4%,观察组疗效明显优于对照组,差异有统计学意义(P<0.05).结论 布地奈德鼻喷雾剂联合西替利嗪片治疗变应性鼻炎的效果显著,对于患者的帮助较大,值得在临床推广应用.%Objective To investigate the clinical effects of budesonide nasal spray plus cetirizine Cinnarizine tablets for the treatment of allergic rhinitis. Methods From June 2007 to August 2011, 71 patients in our hospital with allergic rhinitis, 71 patients were randomly divided into two groups, 36 cases of the observation group, 35 cases of the control group, the observation group were using cloth budesonide nasal spray combined with cetirizine Cinnarizine tablets treatment and control group patients using pure budesonide nasal spray treatment, the course of treatment of the two groups of patients were observed and recorded the data obtained. Results In these 36 patients, 20 cases were cured, 13 cases improved", and 3 cases of inefficiecy, treatment effective rate was 91, 7%,in the control group of 35 patients, 15 cases markedly improved in 10 cases, 10 cases, the treatment efficiency 71. 4%. Conclusion The clinical effect of budesonide nasal spray plus cetirizine Cinnarizine tablets for the treatment of allergic rhinitis, more significantly, for patients with the help of worth in the clinical application.

  17. Allergic Rhinitis (Seasonal Allergies) (Beyond the Basics)

    Science.gov (United States)

    ... reaction could be quickly treated. Because drugs called beta-blockers may interfere with the ability to treat these reactions, people who take beta-blockers are often advised to avoid immunotherapy. If patients ...

  18. Evaluation of the therapeutic efficiency of the comprehensive care combining auricu-lar acupoint magnetic therapy and nasal acupoint massage on the prevention and treatment for the allergic rhinitis%耳穴磁疗联合鼻穴按摩综合护理防治变应性鼻炎疗效评价

    Institute of Scientific and Technical Information of China (English)

    薛海燕

    2016-01-01

    目的:探讨耳穴磁疗联合鼻穴按摩综合护理对变应性鼻炎的防治效果。方法选取2014年6月至2015年2月本院耳鼻咽喉科、针灸科门诊收治的60例患者为研究对象,随机分为对照组(口服抗阻胺药或加用糖皮质激素类鼻喷剂)和治疗组(耳穴磁疗+鼻穴按摩+中医辨证施护)。发作期观察比较两组患者治疗前后鼻炎症状、体征及中医兼症改善情况,缓解期观察比较两组患者鼻炎复发的次数。结果两组患者治疗后鼻炎症状、体征及中医兼证情况均有所改善,治疗组总有效率略高于对照组( P<0.05);治疗后半年内鼻炎复发次数较对照组明显减少,差异具有统计学意义( P<0.01)。结论耳穴磁疗联合鼻穴按摩综合护理防治变应性鼻炎是有效的。%Objective Discussion on the prevention effect of auricular point magnetic therapy combined with nasal point massage on the allergic rhinitis. Methods A total of 60 patients in the department of otorhinolaryngology and the department of acupuncture in our hospital from June 2014 to February 2015 were randomly divided into control group ( oral antihistamines or adding glucocorticoid hormones nasal spray) and treatment group ( ear point magnetic massage combined nasal cavity massage with TCM syndrome differentiation) . Both groups were observed at the stage of attack in terms of the rhinitis symptoms, signs and improvement symptoms of traditional Chinese medicine before and after the treatment, as well as observed and compared two groups of patients in terms of the frequency of remission of rhini-tis. Results After treatment, the rhinitis symptoms and the signs and syndrome of traditional Chinese medicine of the two groups were both improved, with the total effective rate of the treatment group slightly higher than that of the control group (P<0. 05);six months after the treatment, the recurrence rate of rhinitis was significantly reduced in the treat

  19. Effect of treatment of allergic rhinitis and asthma syndrome by inhaling and nasal spray corticosteroids%口鼻吸入丙酸氟替卡松对过敏性鼻炎-哮喘综合症患者的影响

    Institute of Scientific and Technical Information of China (English)

    林士军; 王桂杰; 刘玉春; 徐继庆; 陈兰春; 李观强

    2011-01-01

    Objective To observe the clinical effect of treatment of allergic rhinitis and asthma syndrome(CARAS) by different ways of inhaling corticosteroids. Methods Totally 55 cases of patients suffered from allergic rhinitis and asthma syndrome were randomly divided into two groups. Nasal spray group: 27 cases were treated with fluticasones propionate nasal spray 100μg (2 puffs) a.m. and 150μg (3 puffs) p.m. into each nostril twice daily. Inhaling group: 28 cases were treated with fluticasones propionate inhaling 250μ g (2 puffs) twice daily for 12 weeks, respectively. The symptom scores of rhinitis, asthma, quality of life and pulmonary function were examined before and after treatment. Results The symptom scores of rhinitis , ACT and QOL after treatment in nasal spay groups and inhaling groups were significantly improved (P < 0. 05 ), the scores of rhinitis in nasal spay groups than that in inhaling groups were significantly decreased ( P < 0. 05 ), the scores of ACT, QOL and pulmonary function in inhaling groups than that in nasal spay groups were significantly increased (P < 0. 05). Conclusions The symptoms of rhinitis and asthma, quality of life on CARAS in two groups by two ways of inhaling fluticasones propionate are greatly improved, however, it is not best ways and is no satisfaction that nasal spay or inhaling fluticasones propionate single on CARAS.%目的 探讨口吸及鼻吸激素对过敏性鼻炎-哮喘综合症(CARAS)患者临床症状及生存质量的影响.方法 55例过敏性鼻炎-哮喘综合症患者被随机分为两组,鼻吸组27例,给予丙酸氟替卡松鼻喷雾剂,早上每个鼻孔各2次,晚上每个鼻孔各3次,鼻腔吸入,每喷50μg;口吸组28例,给予丙酸氟替卡松吸入气雾剂,早上吸入2次,晚上吸入2次,经口吸入,每吸125μg.两组每日给药剂量均为500μg,分别于治疗前及治疗12周后统计患者鼻炎症状积分,哮喘控制测试评分,哮喘生存质量评分及肺功能.结果 两组

  20. Measurement of serum IL-21 in patients with allergic rhinitis and its significance%变应性鼻炎患者血清IL-21检测及意义

    Institute of Scientific and Technical Information of China (English)

    黄雪琨; 杨钦泰; 陈玉莲; 张革化

    2011-01-01

    Objective To detect the serum IL-21 in patients with allergic rhinitis (AR) and its correlation with allergen-specific IgE levels. Method Subjects were divided into two groups: the AR group (n=24) and the healthy control group (n=12). The serum levels of IL-21 and specific IgE for common inhalant allergens were determined by using the ELASA method and ImmunoCAP 100 system, respectively. Results Allergen-specific IgE levels in AR patients were categorized as grade 2 (9 cases), grade 3 (4 cases), grade 4 (8 cases), grade 5 (lease) and grade 6 (2 cases), respectively. While in healthy controls they were all categorized as grade 0. The serum levels of IL-21 was 199±97.86 pg/mL in AR patients and 7.58±5.49 pg/mL in healthy controls (P>0.05). Furthermore, no significant correlation was observed between the serum levels of IL-21 and specific IgE for house dust mite (P>0.05). Conclusion Our study suggested that IL-21 might be not involved in the pathogenesis of AR.%目的 探讨IL-21在变应性鼻炎患者血清中的含量及其与变应原特异性IgE水平的相关性.方法 研究对象分为变应性鼻炎组(24例)和正常对照组(12例),分别采用ELISA法和ImmunoCAP 100全自动免疫荧光定量分析系统检测受试者血清中IL-21含量及常见吸入物变应原特异性IgE水平.结果 变应性鼻炎组血清特异性IgE水平分别为2级9例、3级4例、4级8例、5级1例、6级2例;正常对照组血清特异性IgE水平均为0级.变应性鼻炎和正常对照组血清IL-21含量分别为(199±97.86) pg/mL和(7.58±5.49) pg/mL,差异无统计学意义(P>0.05).变应性鼻炎患者血清IL-21含量与屋尘螨变应原特异性IgE水平无显著相关性(P>0.05).结论 IL-21在变应性鼻炎的发病中可能无明显作用.

  1. 上海宝山地区儿童变应性鼻炎患病率调查%Self-reported prevalence of pediatrics allergic rhinitis in Baoshan district

    Institute of Scientific and Technical Information of China (English)

    鲍爱春; 龚齐; 章如新; 朱静静; 支纪治; 刘燕萍

    2011-01-01

    目的 调查上海市宝山区7~12岁儿童变应性鼻炎自报患病率并分析其相关危险因素.方法 2010年3~6月,选择宝山区5所小学-~五年级(7~12岁)学生为研究对象,设计"宝山区儿童变应性鼻炎问卷调查表",进行流行病学调查.对结果进行统计学处理.结果 发放问卷总数为3046份,回收2464份,应答率80.9%,有效问卷2313份.宝山区7~12岁儿童变应性鼻炎自诉现患率为23.9%(553/2313),其中男26.1%(314/1203),女21.5%(239/1110),有统计学意义(X=6.627,P<0.01).自报患病率随年龄增长而上升.在变应性鼻炎的危险因素中,被动吸烟、家养宠物、居住环境、湿疹史,个人过敏史、家族过敏史可能与变应性鼻炎有一定相关性.结论 宝山区7~12岁儿童变应性鼻炎自报现患率为23.9%.初步了解宝山区变应性鼻炎流行病现状,为上海变应性鼻炎防治提供参考.%Objective To investigate the self-reported prevalence of pediatric allergic rhinitis(AR)sufferers and analyze its related risk factors in Baoshan district, Shanghai city. Methods The pupils in Baoshan district of shanghai from 7 to 12 years old from March to June were included in the study. A questionnaire survey on AR was designed for the study. The data were performed statistical analysis.Results Totally 2464 were returned in 3046 questionnaires,the response rate was 80.9 %. 2313 questionnaires were available. The selfreported prevalence of AR was 23.9% (558/2313), male was 26.1%(314/1203),female was 21.5 %(239/1110, there were significant difference in then.The self-reported prevalence of AR was increasing as children age. Passive smoking favor animal, living environment,history of eczema,personal and family allergen history might be related to prevalence of AR. Conclusion The self-reported prevalence of AR in children aged from 7 to 12 in Baoshan is 23.9 %. This survey proveides a first-hand data on epidemic features of children with AR in Baoshan

  2. Investigation on status and risk factors of allergic rhinitis in children%儿童变应性鼻炎的现状调查及危险因素分析

    Institute of Scientific and Technical Information of China (English)

    黄懿娟; 武军驻

    2014-01-01

    Objective To understand the clinical features and risk factors of allergic rhinitis(AR) in children,in order to provide guidance for early diagnosis and treatment. Methods A total of 183 children with AR,who received treatment in the hos-pital from January 2009 to December 2010,were selected as case group by cases-control study;meanwhile another 183 children without disease of respiratory system were selected as control group. The related questionnaires were issued among the patients and patients in the case group for investigation. After returning,the results were entered into the database and analyzed statistically. Relative factors analysis in the two groups was conducted. Results The age of children with AR were mainly distributed in pre-school age(3-7 years old),accounting for 45.4%(83/183);90.7%(166/183) of the children with AR was combined with asthma;among the 183 patients,32.8%(60/183) of which had a history of drug allergy,and 52.5%(96/183) had a family history of aller-gies. Family history of allergy,exposure to pollen and eczema were major risk factors for AR. Conclusion The children,who have family history of allergy,history of eczema and long-term exposure to pollen,are susceptible to AR, and early prevention and treatment of AR can prevent the occurrence of asthma.%目的:了解儿童变应性鼻炎(AR)的发病特点及危险因素,为其早期临床诊断和治疗提供指导。方法采用病例对照研究方法,选取2009年1月至2010年12月确诊的183例AR患儿为病例组,并选取同期非呼吸系统疾病183例儿童为对照组,对病例组AR患儿及家长发放相关问卷进行调查,问卷收回后录入数据库,进行统计分析,对两组进行相关因素分析。结果变应性鼻炎患儿的年龄大多分布在学龄前期(3~7岁),占45.4%(83/183);有90.7%(166/183)的AR患儿合并哮喘;183例患儿中32.8%(60/183)有药物过敏史,52.5%(96/183)有家族过敏史;家族过

  3. 变应性鼻炎患者血清褪黑素、一氧化氮水平的季节测定及临床意义%The clinical study on seasonal rhythm of melatonin and nitric oxide of patients with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    张波; 郭燕冰; 许继宗; 王普艳; 李洁; 司英奎

    2015-01-01

    目的:探讨变应性鼻炎患者血清褪黑素及一氧化氮( nitric oxide,NO)水平的季节变化及临床意义。方法选择符合变应性鼻炎标准的成年患者41例,其中男21例、女20例。采取自身对照的方法,分别在春分、夏至、秋分、冬至4个节气的前后各1个月进行血清褪黑素、NO水平的检测。结果血清褪黑素水平秋冬季节有较高表达,秋春、冬春、秋夏、冬夏对比差异有显著性(P<0.01);血清NO水平在冬季有较高表达,冬春对比差异有显著性(P<0.01),冬夏对比差异有显著性(P<0.01)。血清褪黑素、NO在春、夏、秋三季的水平变化有显著的相关性(春季r分别为0.518、0.518,P<0.01;夏季r分别为0.485、0.485,P<0.01;秋季r分别为0.437、0.437,P<0.01)。结论血清褪黑素、NO水平季节变化的表达,进一步验证了中医“天人相应”的理论,在变应性鼻炎发病过程中起到较重要的作用,对临床的预防及诊治有较大的参考价值。%Objective To assess whether the levels of serum melatonin and nitric oxide ( NO) correlate with reasons in allergic rhinitis patients. Method 41 allergic rhinitis patients were selected which included male 21 cases;female 20 cases. Self-control method was taken and the levels of MT and NO were measured which obtained all serum sam-ples in one month near to Vernal Equinox, Summer Solstice, Autumn Equinox and Winter Solstice. Result The lev-els of melatonin were much higher in winter and autumn than those in spring and summer; the levels of NO were much higher in winter than those in spring and summer. Whether in spring, summer and autumn the levels of me-latonin and NO have significant correlations (in spring the r was 0. 518,0. 518 respectively, P<0. 01; in summer the r was 0. 485,0. 485 respectively, P<0. 01; in autumn the r was 0. 437,0. 437 respectively, P<0. 01). Conclusion The seasonal rhythm expression of melatonin and NO verified the Chinese medicine theory of

  4. The clinical study on seasonal rhythm of melatonin and nitric oxide of patients with allergic rhinitis%变应性鼻炎患者血清褪黑素、一氧化氮水平的季节测定及临床意义

    Institute of Scientific and Technical Information of China (English)

    张波; 郭燕冰; 许继宗; 王普艳; 李洁; 司英奎

    2015-01-01

    目的:探讨变应性鼻炎患者血清褪黑素及一氧化氮( nitric oxide,NO)水平的季节变化及临床意义。方法选择符合变应性鼻炎标准的成年患者41例,其中男21例、女20例。采取自身对照的方法,分别在春分、夏至、秋分、冬至4个节气的前后各1个月进行血清褪黑素、NO水平的检测。结果血清褪黑素水平秋冬季节有较高表达,秋春、冬春、秋夏、冬夏对比差异有显著性(P<0.01);血清NO水平在冬季有较高表达,冬春对比差异有显著性(P<0.01),冬夏对比差异有显著性(P<0.01)。血清褪黑素、NO在春、夏、秋三季的水平变化有显著的相关性(春季r分别为0.518、0.518,P<0.01;夏季r分别为0.485、0.485,P<0.01;秋季r分别为0.437、0.437,P<0.01)。结论血清褪黑素、NO水平季节变化的表达,进一步验证了中医“天人相应”的理论,在变应性鼻炎发病过程中起到较重要的作用,对临床的预防及诊治有较大的参考价值。%Objective To assess whether the levels of serum melatonin and nitric oxide ( NO) correlate with reasons in allergic rhinitis patients. Method 41 allergic rhinitis patients were selected which included male 21 cases;female 20 cases. Self-control method was taken and the levels of MT and NO were measured which obtained all serum sam-ples in one month near to Vernal Equinox, Summer Solstice, Autumn Equinox and Winter Solstice. Result The lev-els of melatonin were much higher in winter and autumn than those in spring and summer; the levels of NO were much higher in winter than those in spring and summer. Whether in spring, summer and autumn the levels of me-latonin and NO have significant correlations (in spring the r was 0. 518,0. 518 respectively, P<0. 01; in summer the r was 0. 485,0. 485 respectively, P<0. 01; in autumn the r was 0. 437,0. 437 respectively, P<0. 01). Conclusion The seasonal rhythm expression of melatonin and NO verified the Chinese medicine theory of

  5. Effect of treatment on combined allergic rhinitis and asthma syndrome by different ways of inhaling corticosteroids%激素不同吸入方法对过敏性鼻炎-哮喘综合症患者临床症状及生存质量的影响

    Institute of Scientific and Technical Information of China (English)

    林士军; 王桂杰; 刘玉春; 徐继庆; 李观强; 陈兰春

    2012-01-01

    Objective To observe the clinical effect of treatment of combined allergic rhinitis and asthma syndrome (CAR AS) by different ways of inhaling corticosteroids. Methods Totally 90 cases of patients suffered from combined allergic rhinitis and asthma syndrome were randomly divided into three groups. Nasal spray group: 30 cases were treated with fluticasones propionate nasal spray 100 |xg (2 puffs) a. m. and 150 μg(3 puffs) p. m. into each nostril twice daily. Inhaling group: 30 cases were treated with fluticasones propionate inhaling 250 μg(2 puffs) twice daily. Combined group: 30 cases were treated with fluticasones propionate nasal spay-inhaling combined administration for 12 weeks, respectively. The symptom scores of rhinitis, asthma, quality of life and pulmonary function were examined before and after treatment. Results The symptom scores of rhinitis after the treatment in the nasal spay groups and the nasal spay-inhaling combined groups were significant decreases (P 0.05). The scores of ACT, QOL and pulmonary function in the three groups were significant improvement (P < 0.05) compared with nasal spay groups. The inhaling groups and nasal spay-inhaling combined groups, had significant increases (P <0. 05). The pulmonary function except ACT and QOL was not significant improvement in the nasal spay-inhaling combined groups compared with inhaling groups. Conclusions It is best of all ways that nasal spay-inhaling combined fluticasones propionate can control symptom of rhinitis, and improve control asthma level and quality of life on CARAS.%目的 探讨激素不同吸入方法对CARAS患者临床症状及生存质量的影响.方法 90例CARAS患者被随机分为鼻吸组、口吸组及联合组,分别于治疗前后统计患者鼻炎症状积分,ACT、QOL评分及肺功能指标.结果 鼻吸组和联合组治疗后鼻炎症状评分明显减少(P<0.05),口吸组也有减少,但无统计学意义(P>0.05).口吸组、联合组比鼻吸组治疗后ACT、QOL

  6. Correlação entre a resistência nasal e diferentes parâmetros da rinometria acústica em crianças e adolescentes com e sem rinite alérgica Correlation between nasal resistance and different acoustic rhinometry parameters in children and adolescents with and without allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Gustavo Falbo Wandalsen

    2012-12-01

    Full Text Available Rinometria acústica e rinomanometria são importantes técnicas de avaliação da função nasal. Ainda não está definido em que extensão suas variáveis se correlacionam. OBJETIVO: Avaliar as relações entre a resistência nasal (RN e parâmetros da rinometria acústica em crianças e adolescentes com rinite alérgica e controles. MÉTODO: Vinte pacientes com rinite alérgica e 20 controles foram avaliados. RN, volumes (V4, V5, V2-5 e menores áreas transversais (MC1, MC2 foram mensurados em três momentos: basal, após indução de obstrução nasal e após descongestionante tópico. RESULTADOS: No grupo rinite, a RN se correlacionou significantemente com todos os volumes (V5: r = -0,60 e com MC2. Nos controles, MC1 foi o parâmetro com melhor correlação com a RN no momento basal (r = -0,53 e após descongestionante. Na análise conjunta dos dados, V5 foi o que apresentou as melhores correlações, no momento basal (r = -0,53, quando obstruído (r = -0,58 e após descongestionante (r = -0,46. CONCLUSÕES: Nossos dados demonstram haver correlação negativa e significante entre os valores de rinometria acústica e RN. Em geral, os volumes apresentaram melhor correlação com a RN do que as menores áreas transversais. V5 foi a variável com melhor correlação no grupo com rinite alérgica e na análise conjunta.Acoustic rhinometry and rhinomanometry are important tests used to assess nasal function. The degree to which the parameters of these tests are correlated is yet to be established. OBJECTIVE: This paper aimed to study the correlations between nasal resistance (NR and acoustic rhinometry parameters in children and adolescents with allergic rhinitis and controls. METHOD: Twenty patients with allergic rhinitis and 20 controls were enrolled. NR, volumes (V4, V5, V2-5, and minimal cross-sectional areas (MC1, MC2 were measured in three moments: baseline, after induction of nasal obstruction and after topical decongestant administration

  7. Clinical Experience of Small Qinglong Decoction in the Treatment of 36 Cases with Allergic Rhinitis%小青龙虚化汤治疗过敏性鼻炎36例

    Institute of Scientific and Technical Information of China (English)

    张爱宁

    2015-01-01

    Objective To observe the curative ef ect of virtual Decoction in the treatment of al ergic rhinitis with smal dragon.Methods Using virtual smal Qinglong Decoction in the treatment of 36 cases of al ergic rhinitis.Results 28 cases were cured,7 cases improved,1 cases inef ective,the total ef iciency of 97.2%.Conclusion The curative ef ect of deficiency cold type of smal Qinglong Decoction in the treatment of al ergic rhinitis virtual exact.%目的观察小青龙虚化汤治疗过敏性鼻炎的疗效。方法采用小青龙虚化汤治疗过敏性鼻炎36例。结果痊愈28例,好转7例,无效1例,总有效率97.2%。结论小青龙虚化汤治疗过敏性鼻炎之虚寒型疗效确切。

  8. 白三烯受体拮抗剂孟鲁司特治疗变应性鼻炎的荟萃分析%Meta-analysis of leukotriene receptor antagonist montelukast in the treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    陆忆; 殷敏; 程雷

    2014-01-01

    鲁司特或氯雷他定.%Objective To evaluate the treatment outcomes of leukotriene receptor antagonists (LTRA) as monotherapy or combined with the second-generation oral H1-histamines in the treatment of allergic rhinitis (AR),and to provide a basis for optimizing clinical therapeutic strategies.Methods PubMed,EMBASE,CBMdisc and CJFD databases,retrieving randomized controlled trials (RCTs) of AR therapy literatures were searched.Based on the literature inclusion and exclusion criteria,the related literatures were selected and the quality was evaluated by using the Jadad scale.Meta-analysis was performed by Stata 12.1 software.For continuous outcomes,the weighted mean difference (WMD) and its 95% confidence intervals (CI) were calculated.The forest plots were drawn.The treatment outcomes included daytime nasal symptom scores (DNSS),nighttime symptom scores (NSS),composite symptom scores (CSS),daytime eye symptom scores (DESS),and the rhinoconjunctivitis quality of life questionnaire (RQLQ) were used to evaluate the therapeutic effects of LTRA on seasonal and perennial AR.Results Eleven of clinical RCTs including 14 809 cases of AR patients,aged 15 to 85 years old,were available for Meta-analysis.Montelukast,a drug of LTRA,was primarily evaluated in the study.The results of Metaanalysis showed:(1) Compared with the placebo,montelukast statistically significantly reduced the DNSS,NSS,CSS,and RQLQ scores in patients with seasonal and perennial AR,as well as the DESS in patients with seasonal AR.(2) There were no statistical differences in the improvement of the CSS,DESS,and RQLQ scores in patients with seasonal AR after the treatment by montelukast compared with loratadine,a secondgeneration oral H1-histamine.(3) Montelukast statistically significantly reduced the NSS,but not DNSS,in patients with seasonal AR compared with loratadine.(4) The combination therapy of montelukast and loratadine statistically significantly improved the CSS compared with either montelukast or loratadine monotherapy

  9. AB042. Allergy Working Group Update: the burden and management of rhinitis and rhinosinusitis in UK primary care

    Science.gov (United States)

    Fokkens, Wytske; Nibber, Anjan; Chisholm, Alison; Hellings, Peter; Skinner, Derek; Price, David

    2016-01-01

    Background Rhinitis and rhinosinusitis are diseases of the upper airways with a high prevalence and when they are chronic with a high quality of life burden on patients and costs for society. To date, data on the primary care burden of rhinitis and rhinosinusitis are limited as is knowledge of how primary care physicians currently manage these patients. This study aims to quantify the burden of CRS and characterize related management approaches in UK primary care. Methods Patients with diagnostic codes for rhinitis and rhinosinusitis were identified within the UK’s Optimum Patient Care Research Database (OPCRD), a respiratory enriched primary care database. Consultations over a 5-year period (latest for each patient) code for rhinitis and rhinosinusitis symptoms resulting in prescriptions for antibiotics, oral steroids and/or antihistamines were identified. Diagnostic codes were used to further categorize patients into acute/chronic rhinitis/rhinosinusitis and allergic/non allergic chronic rhinitis subgroups. Prescribed therapies were categorized as: antibiotics (all); steroids (oral, injectable, nasal) and antihistamines, nasal spray and eye drops and mapped across rhinitis/rhinosinusitis and allergic/non-allergic patient subgroups. Results A total of 685,429 patients were identified with rhinitis and rhinosinusitis diagnostic codes. Of these patients: 80,900 (5%) had a diagnostic code for acute rhinitis (common cold); 176,353 (26%) for acute rhinosinusitis; 65,610 (10%) for chronic rhinosinusitis; 306,030 (45%) for chronic allergic rhinitis; 4,747 (1%) for chronic non-allergic rhinitis and 51,790 (8%) undefined chronic rhinitis. A total of 1,664,068 consultations for rhinitis and rhinosinusitis symptoms were identified, of which 185,730 (27%) resulted in an antibiotic prescription, 5,597 (0.8%) in an oral steroid prescription and 1,898 (0.3%) in an antibiotic and oral steroid prescription. Drug prescribing varied markedly across diagnostic subgroups with

  10. Futura study: evaluation of efficacy and safety of rupatadine fumarate in the treatment of persistent allergic rhinitis Estudo futura: avaliação da eficácia e segurança do fumarato de rupatadina no tratamento da rinite alérgica persistente

    Directory of Open Access Journals (Sweden)

    Olavo de Godoy Mion

    2009-10-01

    Full Text Available Allergic rhinitis affects 10-30% of the population, negatively impacting one's quality of life and productivity. It has been associated with sinusitis, otitis media, sleep disorders, and asthma. Rupatadine is a second generation antihistamine with increased affinity to histamine receptor H1; it is also a potent PAF (platelet-activating factor antagonist. It starts acting quite quickly, offers long lasting effect, and reduces the chronic effects of rhinitis. AIM: this study aims to assess the efficacy and safety of rupatadine in the treatment of persistent allergic rhinitis. MATERIALS AND METHOD: this is a multi-centric open prospective study. This study included 241 patients from 13 centers in Brazil and was held between October of 2004 and August of 2005. Signs and symptoms of rhinitis and tolerance to medication were analyzed after one and two weeks of treatment. RESULTS: reduction on general scores from 8.65 to 3.21 on week 2 (pA rinite alérgica acomete 10 a 30% da população, interferindo na qualidade de vida e na capacidade produtiva. Está associada à sinusite, otite, roncopatias e asma. A Rupatadina é um anti-histamínico de segunda geração, com elevada afinidade ao receptor histamínico H1 e potente inibição do fator ativador plaquetário (PAF. Tem rápido início de ação, longa duração e reduz os efeitos crônicos da rinite. OBJETIVO: Avaliar a eficácia e segurança da rupatadina no tratamento da rinite alérgica persistente. MATERIAL E MÉTODO: Estudo multicêntrico, aberto, prospectivo. Foram selecionados 241 pacientes em 13 centros no Brasil durante o período de outubro de 2004 a agosto de 2005. Foram analisados os sinais e sintomas da rinite e a tolerabilidade após 1 e 2 semanas. RESULTADOS: Redução do escore geral de 8,65 para 3,21 na semana 2 (p<0,001. Todos os sinais e sintomas melhoraram significativamente, e no primeiro dia de tratamento (p<0,001, com exceção da obstrução e secreção nasal, a partir do

  11. 舌下含服粉尘螨滴剂对小儿过敏性鼻炎伴腺样体肥大的疗效%Specific Sublingual Immunotherapy with Dermatophagoides Farinae Drops for Allergic Rhinitis Complicated by Adenoid Hypertrophy in Children

    Institute of Scientific and Technical Information of China (English)

    吕显林; 岳耀光; 张永强; 朱绪亮; 张俊; 郭军; 黄丽芳; 梁仕才

    2015-01-01

    ABSTRACT:Objective To investigate the curative effects of specific sublingual immunotherapy with Dermatophagoides farinae drops on allergic rhinitis complicated by adenoid hypertrophy in children.Methods Ninety children with allergic rhinitis and adenoid hypertrophy randomly re-ceived sublingual immunotherapy with Dermatophagoides farinae drops(group A,n=30),conven-tional treatment with anti-allergic drugs(group B,n=30),or their combination(group C,n=30). Nasal symptoms(nasal congestion,nasal itching,sneezing,runny nose,etc.)and snoring symp-toms(labored breathing,waking up repeatedly,snoring,mouth breathing,etc.)were evaluated u-sing the visual analogue scale(VAS)before and after treatment for 6 months.The maximum thickness of adenoid/anterior-posterior diameter of nasopharyngeal air space (A/N)ratio was measured by X-ray absorptiometry and computed tomography.Results Before treatment,there were no significant differences among the three groups in VAS scores of nasal symptoms and sno-ring symptoms,as well as in A/N ratio(P >0.05).After treatment for 6 months,VAS scores of nasal symptoms and snoring symptoms and A/N ratio obviously reduced in all the three groups (P 0.05).Compared with group B,VAS scores of snoring symp-toms and A/N ratio increased in group A but decreased in group C(P <0.05).Conclusion There is a close relationship between allergic rhinitis and adenoid hypertrophy in children.Specific sub-lingual immunotherapy not only improves nasal allergic symptoms,but also relieves snoring symptoms through reducing adenoid volume.Therefore,specific sublingual immunotherapy pro-vides a new method for non-surgical treatment of allergic rhinitis complicated by adenoid hyper-trophy.%目的:探讨儿童过敏性鼻炎伴腺样体肥大患儿采用舌下含服粉尘螨滴剂治疗的疗效。方法将90例过敏性鼻炎合并腺样体肥大的患儿按随机数字表法分为 A、B、C 3组,每组30例。A 组给予舌下含服粉尘螨滴剂治疗;B 组

  12. Investigation of the effect of Loratadine associated with physiological seawater nasal wash spray in the treat-ment of children with allergic rhinitis%氯雷他定联用生理性海水喷雾洗鼻液治疗儿童变应性鼻炎84例临床研究

    Institute of Scientific and Technical Information of China (English)

    潘彧

    2014-01-01

    Objective To investigate the clinical efficacy and safety of loratadine associated with physiological seawater nasal wash spray in the treatment of children with allergic rhinitis. Method 84 children with allergic rhinitis were randomly divided into observation group and control group,42 cases in each group. All children were given oral loratadine,and children in the observation group was treated with physiological seawater nasal wash spray for four weeks,the clinical efficacy and adverse drug reactions were observed. Results The to-tal symptom score in the two groups decreased significantly after treatment than before treatment(t=5. 863,4. 318,P<0. 01),total symp-tom score in the observation group(4. 21 ±0. 62)was significantly lower than that in the control group(t=4. 117,P<0. 05). The teffi-ciency(45. 2%)and total efficiency(92. 9%)in the observation group were better than that in the control group(χ2 =4. 266,10. 182, P<0. 05). Conclusion Loratadine associated with physiological seawater nasal wash spray in the treatment of children with allergic rhinitis is safe and effective,and suitable for clinical application.%目的:探讨氯雷他定联用生理性海水喷雾洗鼻液治疗儿童变应性鼻炎的临床疗效及安全性。方法:将84例儿童变应性鼻炎患儿随机分成观察组和对照组,每组42例,两组均给予氯雷他定口服治疗,观察组加用生理性海水喷雾洗鼻液喷鼻治疗,两组疗程均为4周,观察两组患儿临床疗效及药物不良反应。结果:两组患儿治疗后症状总评分均较治疗前显著降低(t=5.863,4.318,P<0.01),观察组症状总评分(4.21±0.62)明显低于对照组(t=4.117,P<0.05)。观察组显效率(45.2%)、总有效率(92.9%)明显优于对照组(χ2=4.266,10.182,P<0.05)。结论:氯雷他定联用生理性海水喷雾洗鼻液治疗儿童变应性鼻炎安全、有效,适合临床推广应用。

  13. Efficacy of Fexofenadine in the Indian Population suffering from Alergic Rhinitis & Chronic Urticaria

    Directory of Open Access Journals (Sweden)

    Bikash Medhi

    2006-04-01

    Full Text Available The present study was designed to evaluate the efficacy of fexofenadine in the Indian population sufferingfrom allergic rhinitis and chronic urticaria. A total number of two hundred patients of either sex withsimilar demographic profile were included in the study according to inclusion and exclusion criteria.These patients were treated with fexofenadine 120mg once daily for allergic rhinitis and fexofenadine180mg for chronic urticaria for 7 days. The efficacy was evaluated on the basis of symptoms evaluationscale score and medication effectiveness scale score at baseline, on the 3rd day and on the 7th day ofcompletion of treatment. Results indicate that fexofenadine is highly effective in the Indian population(p<0.001 suffering from allergic rhinitis and chronic urticaria.

  14. O impacto da asma, da rinite alérgica e da respiração oral na qualidade de vida de crianças e adolescentes Impact of asthma, allergic rhinitis and mouth breathing in life quality of children and adolescents

    Directory of Open Access Journals (Sweden)

    Silvia Márcia Andrade Campanha

    2008-12-01

    Full Text Available TEMA: qualidade de vida em pacientes com doenças respiratórias. OBJETIVO: rever a literatura enfocando o impacto da asma, da rinite alérgica e da respiração oral na qualidade de vida do paciente, as relações entre essas morbidades e medidas que possam diminuir esse impacto. CONCLUSÃO: há consenso na literatura de que existe inter-relação dessas co-morbidades. O impacto da asma, rinite alérgica e respiração oral afetam diretamente a qualidade de vida do indivíduo não só pela alteração respiratória, mas, também pelos prejuízos comportamentais, funcionais e físicos que ocasionam. O controle dessas morbidades é um tema usual na literatura. Novas propostas terapêuticas englobam o envolvimento de equipes multiprofissionais. Há programas de saúde estruturados com essa visão e objetivam não só melhorar a condição respiratória, mas, também propõem medidas que analisam a qualidade de vida e possibilitam avaliação global do paciente.BACKGROUND: quality of life for patient with breathing illnesses. PURPOSE: to review specialized literature focusing on the impact of asthma, allergic rhinitis and mouth breathing on patient's life quality, the relationship between these illnesses and measures that can reduce this impact. CONCLUSION: it is a consensus in the specialized literature that there is a relationship between these illnesses. Asthma, allergic rhinitis and mouth breathing affect the person's life quality not only producing breathing disorder but also causing behavioral, functional and physical damage. Controlling these illnesses is a usual subject in the specialized literature. New therapeutic proposals include the involvement of multiprofessional teams. There are health programs whose goals are not only the improvement of respiratory condition. They also propose measures that analyze life quality and make possible patient's global evaluation.

  15. Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation

    OpenAIRE

    Kölbeck, Karl-Gustav

    2003-01-01

    In allergic or asthmatic airways disease, upper and lower airways show a uniform eosinophilic inflammation of the mucosa, and bronchial hyperreactivity is a common finding. To study the co- variation of mucosal reactivity in upper and lower airways, histamine challenges of both sites were performed in a group of patients with allergic rhinitis during non-season. Upper airways were monitored during challenge by the use of rhinostereometry, an optical technique that non-invasi...

  16. Frequency of rhinitis and orofacial disorders in patients with dental malocclusion

    Science.gov (United States)

    Imbaud, Tamara Christine de Souza; Mallozi, Márcia Carvalho; Domingos, Vanda Beatriz Teixeira Coelho; Solé, Dirceu

    2016-01-01

    Abstract Objective: To describe the frequency and etiology of rhinitis, oral breathing, types of malocclusion and orofacial disorders in patients treated for dental malocclusion. Methods: Patients with poor dental occlusion (n=89, 8-15 years) undergoing orthodontic treatment at the Postgraduate Orthodontics Center (São Paulo, Brazil) participated in the study. Rhinitis and oral breathing were diagnosed by anamnesis, clinical assessment and allergic etiology of rhinitis through immediate hypersensitivity skin prick test with airborne allergens. The association between types of breathing (oral or nasal), rhinitis and types of dental malocclusion, bruxism and cephalometric alterations (increased Y axis of facial growth) compared to standard cephalometric tracing (Escola de Odontologia da Universidade de São Paulo) were assessed. Results: The frequency of rhinitis in patients with dental malocclusion was 76.4% (68), and, of these, 81.7% were allergic (49/60 positive skin prick test), whereas the frequency of oral breathing was 62.9%. There was a significant association between an increased Y axis of facial growth and oral breathing (pbruxism. Conclusions: The frequency of rhinitis in children with dental malocclusion is higher than that in the general population, which is approximately 30%. Patients with oral breathing have a tendency to a dolichofacial growth pattern (increased Y axis of facial growth). In patients with rhinitis, regardless of the presence of oral breathing, the dolichofacial growth tendency was not observed. PMID:26631324

  17. 变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的临床对照研究%Controlled Clinical Studies on Fluticasone Propionate Spray for Allergic Rhinitis Children Suffering with Adenoidal Hypertrophy

    Institute of Scientific and Technical Information of China (English)

    吴莉; 姜妍; 沈莹

    2016-01-01

    Objective:To research the efficacy and safety of fluticasone propionate spray for allergic rhinitis children suffering with adenoidal hypertrophy. Methods:Totally 160 allergic rhinitis with adenoids growth children were in the observation group, in which 109 cases were diagnosed as adenoidal hypertrophy. Totally 157 adenoids growth children were in the control group, in which 114 cases were diagnosed as adenoidal hypertrophy. The two groups both received fluticasone propionate spray treatment for 3 months, and then the nasal endoscopic adenoidectomy volume, symptom score and adverse reactions were observed and analyzed. Results:Allergic rhi-nitis children suffering with adenoidal hypertrophy were mainly in the 3-6-year-old children. After the treatment, adenoids was shrinked in 88 patients (80. 73%) in the observation group, which was significantly higher than that in the control group [67(58. 77%), P<0. 01]. Adenoidal hypertrophy was still in 44 patients (35. 03%) of the observation group after the treatment, which was lower than that of the control group [55(68. 13%), P <0. 05]. In addition, the integral differences of nasal congestion, snoring and mouth breathing in the observation group after the treatment were higher than those in the control group, and the differences were statistically significant (P<0. 05). Conclusion:The efficacy of fluticasone propionate spray used in allergic rhinitis children suffering with adenoi-dal hypertrophy is more obvious than that in adenoid hypertrophy children, which can more significantly improve the symptoms of nasal congestion, snoring and mouth breathing.%目的::研究变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的有效性和安全性。方法:选择变应性鼻炎伴腺样体生长的患儿160例做为观察组,其中腺样体肥大者109例;选择同期单纯腺样体生长的患儿157例做为对照组,其中腺样体肥大者114例。两组患儿均接受

  18. Website updates

    Data.gov (United States)

    National Aeronautics and Space Administration — Updates to Website: (Please add new items at the top of this description with the date of the website change) May 9, 2012: Uploaded experimental data in matlab...

  19. 371 Cutaneous Response to Patch Tests with Dermatophagoides Farinae and Dermatophagoides Pteronyssinus in Patients with Chronic Rhinitis

    OpenAIRE

    Garcia-Calderin, Diego; González-Díaz, Sandra; Arias-Cruz, Alfredo; Rojas, Alejandro; Hernandez, Marisela; Gallego, Claudia; Mejia, Karla; Calva, Maricruz; Dominguez, Luis

    2012-01-01

    Background Rhinitis is characterized clinical by chronic runny nose, sneezing, nasal itching, congestion and postnasal discharge, among other symptoms. It´s classified as allergic and non allergic. Skin prick testing is the principal diagnosis method for allergic rhinits. However, there is a group of patients with chronic rhinopathy that have negative skin tests, the objective of this study was to determine the cutaneous response to patch tests with Dermatophagoides farinae and Dermatophagoid...

  20. [Oxidation phenotype as a risk factor for development of allergic diseases].

    Science.gov (United States)

    Niewiński, P; Orzechowska-Juzwenko, K; Patkowski, J; Wolańczyk-Medrala, A; Nittner-Marszalska, M; Rzemisławska, Z

    1999-01-01

    The relationship between genetically determined polymorphic metabolism and susceptibility to allergic diseases has aroused much interest. The aim of our study was to evaluate whether patients with allergic diseases, like atopic asthma and allergic rhinitis differ from healthy persons in their ability to oxidize sparteine as a model drug. The study was completed by 200 persons, 40 patients with allergic diseases--20 with atopic asthma and 20 with allergic rhinitis and 160 healthy volunteers as a control group. The results of our study revealed a predominance of very extensive metabolizers of sparteine among patients with allergic diseases in comparison with healthy volunteers. The difference in the oxidation metabolic ratio (MR) frequency distribution between patients with allergic diseases and healthy persons was statistically significant. Relative risk (odds ratio) of development of atopic asthma was 3.29 times higher, and that of allergic rhinitis 2.94 times higher for persons with very extensive oxidation phenotype. Our results represent some evidence for a possible relationship between extensive, rapid oxidation phenotype and the higher susceptibility to development of atopic asthma and allergic rhinitis. PMID:10592724

  1. Frequency of rhinitis and orofacial disorders in patients with dental malocclusion

    Directory of Open Access Journals (Sweden)

    Tamara Christine de Souza Imbaud

    2016-06-01

    Full Text Available Abstract Objective: To describe the frequency and etiology of rhinitis, oral breathing, types of malocclusion and orofacial disorders in patients treated for dental malocclusion. Methods: Patients with poor dental occlusion (n=89, 8-15 years undergoing orthodontic treatment at the Postgraduate Orthodontics Center (São Paulo, Brazil participated in the study. Rhinitis and oral breathing were diagnosed by anamnesis, clinical assessment and allergic etiology of rhinitis through immediate hypersensitivity skin prick test with airborne allergens. The association between types of breathing (oral or nasal, rhinitis and types of dental malocclusion, bruxism and cephalometric alterations (increased Y axis of facial growth compared to standard cephalometric tracing (Escola de Odontologia da Universidade de São Paulo were assessed. Results: The frequency of rhinitis in patients with dental malocclusion was 76.4% (68, and, of these, 81.7% were allergic (49/60 positive skin prick test, whereas the frequency of oral breathing was 62.9%. There was a significant association between an increased Y axis of facial growth and oral breathing (p<0.001, as well as between oral breathing and rhinitis (p=0.009. There was no association between rhinitis and bruxism. Conclusions: The frequency of rhinitis in children with dental malocclusion is higher than that in the general population, which is approximately 30%. Patients with oral breathing have a tendency to a dolichofacial growth pattern (increased Y axis of facial growth. In patients with rhinitis, regardless of the presence of oral breathing, the dolichofacial growth tendency was not observed.

  2. Frequency of rhinitis and orofacial disorders in patients with dental malocclusion

    Science.gov (United States)

    Imbaud, Tamara Christine de Souza; Mallozi, Márcia Carvalho; Domingos, Vanda Beatriz Teixeira Coelho; Solé, Dirceu

    2016-01-01

    Abstract Objective: To describe the frequency and etiology of rhinitis, oral breathing, types of malocclusion and orofacial disorders in patients treated for dental malocclusion. Methods: Patients with poor dental occlusion (n=89, 8-15 years) undergoing orthodontic treatment at the Postgraduate Orthodontics Center (São Paulo, Brazil) participated in the study. Rhinitis and oral breathing were diagnosed by anamnesis, clinical assessment and allergic etiology of rhinitis through immediate hypersensitivity skin prick test with airborne allergens. The association between types of breathing (oral or nasal), rhinitis and types of dental malocclusion, bruxism and cephalometric alterations (increased Y axis of facial growth) compared to standard cephalometric tracing (Escola de Odontologia da Universidade de São Paulo) were assessed. Results: The frequency of rhinitis in patients with dental malocclusion was 76.4% (68), and, of these, 81.7% were allergic (49/60 positive skin prick test), whereas the frequency of oral breathing was 62.9%. There was a significant association between an increased Y axis of facial growth and oral breathing (p<0.001), as well as between oral breathing and rhinitis (p=0.009). There was no association between rhinitis and bruxism. Conclusions: The frequency of rhinitis in children with dental malocclusion is higher than that in the general population, which is approximately 30%. Patients with oral breathing have a tendency to a dolichofacial growth pattern (increased Y axis of facial growth). In patients with rhinitis, regardless of the presence of oral breathing, the dolichofacial growth tendency was not observed. PMID:26631324

  3. Website Optimization

    CERN Document Server

    King, Andrew

    2008-01-01

    Remember when an optimized website was one that merely didn't take all day to appear? Times have changed. Today, website optimization can spell the difference between enterprise success and failure, and it takes a lot more know-how to achieve success. This book is a comprehensive guide to the tips, techniques, secrets, standards, and methods of website optimization. From increasing site traffic to maximizing leads, from revving up responsiveness to increasing navigability, from prospect retention to closing more sales, the world of 21st century website optimization is explored, exemplified a

  4. Role of Substance P in the Pathogenesis and Treatment of Allergic Rhinitis%P物质在变应性鼻炎发病机制和治疗中的作用

    Institute of Scientific and Technical Information of China (English)

    李斯斯; 阮标; 余咏梅

    2013-01-01

    Substance P involved in the late phase of allergic reaction among AR patients. It is important mediator and common messenger substance which connected neuroendocrine to immune system. It provided a new approach to the treatment of AR, by focusing on substance P as target point.%P物质参与变应性鼻炎晚期过敏反应过程,是重要的神经内分泌-免疫系统相互联系和作用的介导物质和共同的信使物质.以P物质为作用靶点将成为治疗变应性鼻炎的新途径.

  5. 舌下含服粉尘螨滴剂脱敏治疗变应性鼻炎失败原因分析%Sublingual administration of dermatophagoides farinae farinae drops in desensitization treatment of allergic rhinitis: analysis of failure

    Institute of Scientific and Technical Information of China (English)

    石彬; 吴昌竹; 张志明; 赵臻; 林晓昕; 马秀岚

    2015-01-01

    Objective To analyze the failure reason of sublingual dermatophagoides farinae farinae drops in desensitization treatment of allergic rhinitis (AR).Methods Totally 71 patients of AR with failure treatment of sublingual dermatophagoides farinae farinae drops from January 2008 to December 2013 were collected.The age,sex,address,cultural degree,economic status (income per capita),the first time and hospital of diagnosis,initial treatment medication,the first treatment time and treatment condition were analyzed.Results The failure reasons included noncompliance to the cause of treatment [100% (71/71)],wrong administration method [97.2% (69/71)],irregular medication [95.8% (68/71)],non environmental intervention [93.0% (66/71)],poor knowledge and confidence for the treatment [77.5% (55/71)],high cost of the treatment [53.5% (38/71)],adverse drug reactions [26.8% (19/71)],new allergens [1.4% (1/71)],new disease [1.4% (1/71)].Conclusions The failure reasons regarding sublingual dermatophagoides farinae farinae drops in treatment of allergic rhinitis are complicated,the compliance of the patient is the main factor for successful treatment.%目的 分析舌下含服粉尘螨滴剂脱敏治疗变应性鼻炎(AR)失败原因.方法 选取解放军第二○二医院耳鼻喉科门诊2008年1月至2013年12月71例舌下含服粉尘螨滴剂治疗AR失败患者,进行面对面问卷调查,对患者的年龄、性别、住址、文化程度、经济状况(月人均收入)、初次就诊单位、初次确诊时间、初次治疗用药、首次治疗时间、平时治疗情况及对舌下含服粉尘螨滴剂脱敏治疗情况进行登记,统计分析舌下含服粉尘螨滴剂脱敏治疗AR失败的原因.结果 舌下含服粉尘螨滴剂治疗AR失败原因依次为未按照医嘱疗程治疗占100.0% (71/71)、未按照医嘱正确服用药物占97.2%(69/71);未定时服用药物占95.8%(68/71)、未按照医嘱进行环境有效干预占93.0%(66/71)

  6. 苯磺贝他斯汀与氯雷他定治疗过敏性鼻炎:多中心随机双盲临床试验%Bepotastine Besilate versus Loratatine in the Treatment of Allergic Rhinitis: A Multicenter Randomized Double-Blind Comparison Clinical Trial

    Institute of Scientific and Technical Information of China (English)

    李宏; 顾建青; 张罗; 程雷; 刘光辉; 尹佳

    2013-01-01

    Objective To evaluate the efficacy and safety of bepotastine besilate in the treatment of allergic rhinitis- Methods A multi-center, randomized, double-blind, parallel controlled clinical trial was performed- Patients received 10mg bepotastine besilate tablet packaged in capsule twice per day in the study group or 10mg loratatine tablet packaged in capsule after breakfast, placebo of the same weight as 10mg loratatine tablet packaged in capsule after supper in the control group for 14 days- 120 cases were enrolled in each group. Total effective rate was defined as primary outcome of efficacy and SSRI of each nasal as secondary outcome. Results The total effective rate 91. 4% and 91. 2% in bepotastine and loratadine group respectively ( P = 0. 984) . The adverse reaction rate were 16. 1% , 25.4% n bepotastine and loratadine group respectively. The differences were not statistically significant. The incidence of drowsiness was 4. 2% and 14.4% in bepotastine group and loratadine group respectively (P = 0.012). Conclusions Bepotastine besilate was effective in the treatment of allergic rhinitis. The efficacy and safety of bepotastine besilate was similar to loratadine, but incidence of drowsiness was lower than loratadine.%目的 对苯磺贝他斯汀治疗过敏性鼻炎的有效性和安全性进行评价,并与氯雷他定做比较.方法 采用多中心、随机、双盲、平行对照的临床试验,试验组过敏性鼻炎患者120例,每日用苯磺贝他斯汀片10mg,早晚各一次.对照组过敏性鼻炎患者120例,每日用氯雷他定片10mg,每日1次.两组均连续用药14d.疗效评价以治疗的总有效率作为主要指标,症状积分下降指数和鼻腔检查积分下降指数作为次要指标.结果 治疗后,苯磺贝他斯汀受试者总有效率为91.4%,氯雷他定组为91.2%,P=0.984;药物不良反应总发生率分别为16.1%,25.4%.经统计学检验,两组差异均无显著统计学意义.其中苯磺贝他

  7. Clinical Observation on Therapeutic Effect of the Needling Depth of Meridian in Lingshu on Perennial Allergic Rhinitis%《灵枢》经脉针刺深度法治疗常年变应性鼻炎临床观察

    Institute of Scientific and Technical Information of China (English)

    陆永辉

    2012-01-01

    Objective: To observe the clinical efficacy of the needling depth of meridian recorded in Lingshu (Miraculous Pivot) for perennial allergic rhinitis. Methods:62 cases were randomized into treatment group and control group with 31 in each. The points of Dazhui( GV14) , Feishu ( BL13) , Qihai ( CV6) , Guanyuan ( CV4) , Chize ( LU5 ) , Hegu ( LI4) , Zusanli ( ST36 ) , Yin-lingquan(SP9)and Taixi(KI3)with the needling depth of meridian recorded in Lingshu (Miraculous Pivot; Meridian Water) ,2 -6fen(4 ~ 12mm) in depth of the treatment group and with the routine acupuncture depth,8 ~ 15fen( 16 ~ 30mm) in depth of the control group. Even needling technique was applied, and 8 treatments made one session. The therapeutic effect was observed after one and two sessions in the two groups. Results:The total effective rate was 70. 97% in the treatment group which was superior to that of 45. 16% in the control group after one session of treatment,with the significant difference between the two groups(P <0. 05). The total effective rate was 93.55 % in the treatment group which was superior to that of 64. 51 % in the control group after two sessions of treatment, with the significant difference between the two groups ( P < 0. 05 ) . Conclusion: The better clinical efficacy has been achieved for perennial allergic rhinitis treated with needling depth of meridian recorded in Lingshu and its efficacy is superior to that of the routine acupuncture depth. The longer session of treatment is,the more better efficacy is obtained.%目的:观察运用《灵柩》经脉针刺深度法治疗常年变应性鼻炎的临床疗效.方法:将符合诊断标准的62例常年变应性鼻炎患者,随机分为治疗组《灵枢》经脉针刺深度法和对照组常规针刺深度法各31例.穴取大椎、肺俞、气海、关元、尺泽、合谷、足三里、阴陵泉、太溪.治疗组按照《灵柩·经水》篇,经脉针刺深度2~6分(4~12mm),对照组按照常规针刺深度8 ~15

  8. Treatment of allergic rhinitis with asthma by different ways of inhaling corticosteroids%局部应用糖皮质激素不同给药方式治疗季节性变应性鼻炎合并哮喘的临床观察

    Institute of Scientific and Technical Information of China (English)

    张华; 陈璇; 王惠妩; 向阳冰

    2009-01-01

    目的 观察比较局部应用糖皮质激素不同给药方式治疗季节性变应性鼻炎合并轻-中度哮喘患者的临床疗效.方法 分别采用鼻喷、口吸及鼻喷+口吸联合吸入糖皮质激素(布地奈德)治疗90例季节性变应性鼻炎合并轻-中度哮喘患者12周,观察治疗前后血清总IgE、嗜酸性粒细胞阳离子蛋白(eosinophil cationic protein,ECP)、白细胞介素5(interleukin-5,IL-5)水平、肺功能变化及鼻炎、哮喘记分.结果 三组患者治疗后血清总IgE、ECP、IL-5水平和鼻炎、哮喘记分均明显下降,组内治疗前后比较,差异均有统计学意义(P值均0.05).口吸组治疗前后第1秒用力呼气容积(forced expiratory volume in 1 second,FEV1)由(2.04±0.45)L提高到(2.47±0.54)L,FEV1/用力肺活量(forced vital capacity,FVC)比值由(72.73±5.59)%提高到(75.42±5.94)%;FEF25%-75%由1.69±0.52提高到2.06±0.77,差异均有统计学意义(P值均<0.05).联合治疗组治疗前后FEV1由(2.32±0.56)L提高到(2.76±0.58)L;FEV1/FVC由(73.80±4.17)%提高到(76.04±4.49)%;FEF25%-75%由2.09±0.45提高到2.34±0.64,差异均有统计学意义(P<0.05).治疗后三组间肺功能指标比较,FEV1差异有统计学意义(P=0.041),采用SNK-q法进行两两比较.认为鼻喷+口吸联合组治疗后FEV1与鼻喷组、口吸组比较差异有统计学意义(P<0.05).本组共失访9例.结论 局部应用糖皮质激素分别经鼻喷、口吸及鼻喷+口吸联合三种方法 治疗变应性鼻炎合并轻-中度哮喘患者,可以明显缓解鼻炎及哮喘症状,在症状记分和血清学检测方面没有明显差异.%Objective To observe the therapeutical effect on allergic rhinitis with asthma by different ways of inhaling orticosteroids. Methods Ninety patients suffering from allergic rhinitis with asthma were classified into three groups in random and treated with budesonide (BUD) by nasal spay, inhaling and nasal spay-inhaling combined administration for 12 weeks

  9. The high risk factors of allergen sensitization among 518 children with allergic rhinitis symptoms%具有变应性鼻炎症状的518例儿童变应原致敏性高危因素分析

    Institute of Scientific and Technical Information of China (English)

    戴伟利; 葛文彤; 张杰; 张亚梅

    2014-01-01

    Objective To study the high risk factors of allergen sensitization among 1-16 years old children with allergic rhinitis (AR) symptoms.Methods Medical history was collected from 518 children with AR symptoms aged 1 to 16 years old between April 2011 and November 2012,including five aspects:basic information,disease characteristics,associated with other allergic diseases,growth and development history and genetic history and so on.The allergens were determined by UniCAP 100 system.The high risk factors of allergen sensitization(sIgE ≥ grade Ⅲ) among 1-16 years old children with AR symptoms were analyzed.The data processing and statistical analysis were conducted by SPSS 17.0 software.Results Three hundred and thirty of 518 patients (63.7%) could be diagnosed as AR.The primary allergen was mixed fungal(52.4%).The highest percentage of allergen sIgE ≥ grade Ⅲ accounted for the corresponding allergen positive cases was 71.1% (mixed fungal).Single factor analysis of clinical characteristics in the groups of AR and non AR showed that the history of months (x2 =-3.591),concomitant allergic conjunctivitis (x2 =12.325) and cats or dogs at home (x2 =5.615) were statistically significant between the two groups(all P < 0.05).In children with AR,single factor analysis of clinical characteristics in the groups of whether positive allergen level ≥ grade Ⅲ showed that the concomitant asthma (x2 =4.097),breastfeeding(x2 =4.186),the housing situation (x2 =4.360) and the bedroom toward (x2 =4.656) were statistically significant between the two groups (all P < 0.05).In children with AR,single factor analysis of clinical characteristics in different age groups showed that the history of months(x2 =64.999),concomitant eczema (x2 =24.056),concomitant insect bite dermatitis (x2 =9.148),cats or dogs at home (x2 =8.529) and mother suffered from AR (x2 =9.565) were statistically significant in different age groups (all P < 0.05).Conclusion The study revealed that the

  10. Sensitization to Mites and Total IgE in Allergic Children

    Directory of Open Access Journals (Sweden)

    Nivia López Ramírez

    2013-10-01

    Full Text Available Incidence and prevalence of allergic diseases during childhood have significantly increased in developed countries over the last 20 to 30 years. The role of the inhalant allergens in exacerbating respiratory allergies has been demonstrated. House dust mites are the main causative agents. Environmental pollution and climate changes, along with other factors, have contributed to the increase of these diseases. Among such conditions the most frequent in children are respiratory allergies, particularly allergic rhinitis and bronchial asthma. The current article presents a review on allergic rhinitis, bronchial asthma and IgE levels in children, emphasizing on epidemiology and trigger factors.

  11. 江苏南通地区变应性鼻炎与支气管哮喘患病相关性的遗传流行病学研究%A related heredity epidemiological research on allergic rhinitis and asthma in Nantong region

    Institute of Scientific and Technical Information of China (English)

    马莉; 黄永娟; 管沛; 陈大灵; 章如新; 汪晓雷; 施云剑; 季超; 黄志俊; 钱茂华; 高刚

    2010-01-01

    Objective To discuss the related impact of genetic factors in the incidence of bronchial asthma ( BA) and allergic rhinitis ( AR) in Nantong region, China. Methods By random sampling method, investigation and research on the incidence of genetic epidemiology were carried out in the population of 95 300 on AR and BA. Results The rate of patients with allergic rhinitis with asthma was 25.92% (296/1142), the rate of asthma patients with allergic rhinitis was 40.49% (296/731). The prevalences of AR complicated with BA were 8.19% (280/3418), 3.08% (154/5002) and 3.16% (85/2687) in the first-, second-and third-degree relatives of the probands respectively, while the prevalences of BA complicated with AR were 15.81% (466/2947), 4.61% (229/4967) and 2.51% (134/5345) in the first-,second- and third-degree relatives of the probands respectively, higher than those in the controls (P < 0. 05). The weighted mean heritability of AR in BA patients was 94. 2% ±1.9%, while the weighted mean heritability of BA in AR patients was 81. 8% ±2. 1% , more than 60% , suggesting that both AR and BA were relevant with genetics. Conclusions The incidence of BA and AR has obvious relevance, supporting the theory that the two diseases are an united airway disease and relevant with polygene heredity.%目的 探讨江苏省南通地区遗传因素对变应性鼻炎及支气管哮喘患病相关性的影响.方法 按随机抽样法,对本地区95 300人进行了变应性鼻炎和支气管哮喘患病相关性遗传流行病学的调查研究.人群患病情况采用SPSS11.5进行卡方检验,遗传度采用Falconer公式计算.结果 变应性鼻炎患者并发支气管哮喘的比例为25.92%(296/1142),支气管哮喘患者并发变应性鼻炎的比例为40.49%(296/731).变应性鼻炎患者Ⅰ、Ⅱ、Ⅲ三级亲属支气管哮喘的患病率分别为8.19%(280/3418)、3.08%(154/5002)及3.16%(85/2687);支气管哮喘患者Ⅰ、Ⅱ、Ⅲ三级亲属变应性鼻炎的患病率分别为15

  12. 孟鲁司特钠联和氟替卡松鼻喷雾剂治疗变应性鼻炎合并支气管哮喘患者血清C反应蛋白的影响%The influence on serum C reactive protein in patients with allergic rhinitis and bronchial asthma treated by Montelukast sodium and Fluticasone nasal spray

    Institute of Scientific and Technical Information of China (English)

    郭良斌; 江永琴

    2016-01-01

    目的:研究孟鲁司特钠联和氟替卡松鼻喷雾剂治疗变应性鼻炎(AR)合并支气管哮喘患者血清C反应蛋白的影响。方法选取2010年2月~2015年2月我院接诊的100例AR合并支气管哮喘患者作为本次研究对象。按照随机数表法分为观察组和对照组,对照组给予孟鲁司特钠治疗,观察组给予孟鲁司特钠联和氟替卡松鼻喷雾剂治疗,观察两组患者治疗后血清c反应蛋白水平、临床症状和体征消失时间、治疗疗效情况。结果观察组C反应蛋白水平(5.03±1.02)mg/L小于对照组(18.92±3.02)mg/L,差异具有统计学意义(P<0.05);观察组喘憋消失时间、啰音消失时间、咳嗽消失时间、退热时间、住院时间(2.52±0.71、4.56±0.63、6.93±1.31、4.52±1.01、7.53±1.24)d均小于对照组(3.92±1.03、5.80±0.82、10.39±2.04、5.31±1.30、12.49±2.05)d,差异具有统计学意义(P<0.05);观察组总有效率98.00%(49/50)优于对照组80.00%(40/50),差异具有统计学意义(P<0.05)。结论孟鲁司特钠联和氟替卡松鼻喷雾剂治疗AR合并支气管哮喘疗效显著,能够降低c反应蛋白水平。%Objective To investigate the influence on serum C reactive protein in patients with allergic rhinitis and bronchial asthma treated by montelukast sodium and flutica-sone nasal spray. Methods 100 cases of allergic rhinitis with bronchial asthma were enrolled in this study from Febru-ary 2010 to February 2015. According to the random number table,patients were divided into observation group and control group. The control group was treated with montelukast sodi-um,while the observation group was treated with montelukast sodium and fluticasone nasal spray. Serum C reactive protein level,clinical symptoms,signs disappeared time and treat-ment efficacy were observed. Results C reactive protein level in the observation group(5.03±1.02)mg/L was less than that of the control

  13. Predictors for snoring in children with rhinitis at age 5.

    Science.gov (United States)

    Marshall, Nathaniel S; Almqvist, Catarina; Grunstein, Ronald R; Marks, Guy B

    2007-07-01

    Snoring is often found in allergic diseases and may be an early manifestation of more serious sleep-disordered breathing. We aimed to investigate whether the risk factors for snoring among pre-school children with rhinitis are similar to those for allergic diseases in a birth cohort. The study cohort was drawn from participants in the Childhood Asthma Prevention Study (CAPS). This is a randomized controlled trial of dietary intervention and house dust mite avoidance during the first 5 years of life, aimed at reducing the risk of acquiring asthma and other allergic conditions in children at high-risk for allergic diseases. Parents of children with symptoms of rhinitis at age 5 years (n = 219 out of 516 cohort members) were asked if their child snored: 127 (60%) reported some snoring and 56 (26%) snored more than three times per week. Multiple logistic regression analyses indicated that children who were first-born (adjusted odds ratio, 2.50, 95% CI 1.20-5.21), were exposed to maternal tobacco smoke during the first year of life (2.40, 1.1-5.25), or who had asthma (2.51, 1.14-5.55) and/or eczema (2.29, 1.02-5.13) at age 5 years were more likely to snore. Birth-weight, body mass index at age 4.5, spirometry, and breastfeeding were not related to snoring. Risk factors for snoring are similar to risk factors for allergic disorders. Snoring may be part of the allergic spectrum of diseases. Our data may contribute to clinician's ability to effectively screen for snoring in preschool children. PMID:17534968

  14. Actual therapeutic management of allergic and hyperreactive nasal disorders

    Directory of Open Access Journals (Sweden)

    Rudack, Claudia

    2004-12-01

    Full Text Available Allergic rhinitis (AR and hyperractive disorders of the upper airways, depending upon the type of releasing stimuli, are defined as nasal hyperreactivity, for example in the case of AR, or as non-specific nasal hyperreactivity and as idiopathic rhinitis (IR (synonyms frequently used in the past: non-specific nasal hyperreactivity; vasomotor rhinitis in the case of non-characterised stimuli.An early and professional therapy of allergic disorders of the upper airways is of immense importance as allergic rhinitis is detected in comorbidities such as asthma and rhino sinusitis. The therapeutic concept is influenced by new and further developments in pharmacological substance classes such as antihistamines and glucocorticosteroids. Specific immune therapy, the only causal therapy for AR, has been reviewed over the past few years in respect of the type and pattern of application. However, to date no firm recommendations on oral, sublingual and /or nasal immune therapy have yet been drawn up based on investigations of these modifications.Therapeutic management of IR is aimed at a symptom-oriented therapy of nasal hyperactivity as etiological factors relating to this form of rhinitis are not yet sufficiently known. Drug groups such as mast cell stabilizers, systemic and topic antihistamines, topic and systemic glucocorticosteroids, ipatroium bromide and alpha symphatomimetics belong to the spectrum of the therapeutics employed.

  15. 变应性鼻炎患者血清抗交叉反应性糖类决定簇 IgE 水平与血清 IgE 水平和皮肤点刺试验的关联性分析%Correlation of Anti-CCDIgE Level With Serum IgE Level and Skin Prick Test of Patients With Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    闫津津; 冯珍如; 王全桂; 王美玲; 闫存玲; 李志艳; 郑新芝

    2016-01-01

    龄的增加而增大(χ2趋势=4.264,P =0.039)。结论变应性鼻炎患者anti-CCDIgE水平与血清 IgE(sIgE、tIgE)水平、SPT 结果有一定的关联性,anti-CCDIgE表达情况对确诊变应原的 SPT 和 sIgE 试验有一定干扰,在分析试验结果时应予以注意。%Objective To analyze the correlation of anti - cross reactive carbohydrate determinants IgE(anti-CCDIgE level)with serum IgE level and skin prick test(SPT)of patients with allergic rhinitis. Methods From January 2012 to July 2013,we enrolled 161 patients who were definitely diagnosed as allergic rhinitis or non - allergic rhinitis and accorded with inclusion criteria in Peking University First Hospital. According to whether the patients had non - allergic rhinitis,they were divided into allergic rhinitis group(n = 121)and control group(n = 40). General data of patients were collected,including gender,age and history of hymenoptera stings. Dot immunobloting( dot-IBT)was used to detect the expression of sIgE and anti-CCDIgE. Phadiatop and tIgE expression was detected by FEIA,and SPT was conducted. The correlation of anti-CCDIgE expression with gender,age,history of hymenoptera stings,and the expression of sIgE,phadiatop,tIgE and SPT sensitization was analyzed,and the correlation of SPT results with gender,age,and the experession of phadiatop and tIgE was also analyzed. Results Allergic rhinitis group was higher than control group in the positive expression rate of sIgE,anti-CCDIgE,phadiatop and tIgE and SPT positive rate(P ﹤ 0. 05). The expression of anti - CCDIgE had no correlation with gender,age,expression of mixed trees,humulus,mugwort,household dust,mixed dust mites,mixed fungus,cockroaches,dog dander and cat dander of sIgE atopic allergens,expresion of phadiatop,expresion of trees 1,weeds,spruce,humulus,trees 2,gramineae/ grain, mugwort,robinia pseudoacacia, pine, dust mites, household dust mites, aspergillus fumigatus, candida albicans, cockroaches,gramineae,mould 1,mould 2 and animal

  16. Allergic airway disease : studies on diesel exhaust exposures, oxylipins and antioxidants

    OpenAIRE

    Larsson, Nirina

    2013-01-01

    Allergic airway disease, i.e. allergic rhinitis (AR) and asthma, is a common health problem. The prevalence is increasing in most countries of the world. Traffic-related air pollution has been found to induce and enhance allergic airway disease, but the underlying mechanisms are not known. Oxylipins are fatty acid metabolites, of which several have been linked to asthmatic airway inflammation. Oxylipin profiles have previously been investigated in bronchoalveolar lavage (BAL), mainly reflecti...

  17. Rhinitis: a complication to asthma

    DEFF Research Database (Denmark)

    Hansen, J W; Thomsen, S F; Nolte, H;

    2010-01-01

    Asthma and rhinitis often co-occur, and this potentially increases the disease severity and impacts negatively on the quality of life. We studied disease severity, airway responsiveness, atopy, quality of life and treatment in subjects with both asthma and rhinitis compared to patients with asthma...

  18. Rhinitis and pregnancy: literature review

    Directory of Open Access Journals (Sweden)

    Fábio Azevedo Caparroz

    2016-02-01

    Full Text Available ABSTRACT INTRODUCTION: There is a controversy concerning the terminology and definition of rhinitis in pregnancy. Gestational rhinitis is a relatively common condition, which has drawn increasing interest in recent years due to a possible association with maternal obstructive sleep apnea syndrome (OSAS and unfavorable fetal outcomes. OBJECTIVE: To review the current knowledge on gestacional rhinitis, and to assess its evidence. METHODS: Structured literature search. RESULTS: Gestational rhinitis and rhinitis "during pregnancy" are somewhat similar conditions regarding their physiopathology and treatment, but differ regarding definition and prognosis. Hormonal changes have a presumed etiological role, but knowledge about the physiopathology of gestational rhinitis is still lacking. Management of rhinitis during pregnancy focuses on the minimal intervention required for symptom relief. CONCLUSION: As it has a great impact on maternal quality of life, both the otorhinolaryngologist and the obstetrician must be careful concerning the early diagnosis and treatment of gestational rhinitis, considering the safety of treatment measures and drugs and their current level of evidence.

  19. Self-organizing phenomena at membrane level and low-level laser therapy of rhinitis

    Science.gov (United States)

    Ailioaie, Laura; Ailioaie, C.; Topoliceanu, Fl.

    2000-06-01

    Allergic rhinitis is the most common allergic disease affecting many people worldwide. Low level laser therapy (LLLT) was applied as monotherapy to 32 children, under placebo controlled conditions. There have been used two GaAlAs diode lasers. The density of energy and the frequency 2 sessions daily - were applied under a special experimental protocol of treatment, including endonasal regions treated with an optical fiber and the extrameridian acupuncture points for rhinitis, 10 days monthly, three months consecutively. The initial investigations with fiberoptic rhinoscope revealed a swollen, pale and edematous mucosa, with increased nasal sections, which may be watery to mucoid. At the end of LLLT, the symptoms of rhinitis like sneezing, nasal congestion, stuffy nose, mouth breathing, snoring - have disappeared and the aspect of nasal mucosa was normal. The results could be explained in the new scenario of self-organizing phenomena at membrane level. The physiological beneficial effects may be correlated and possibly explained by self-organizing paradigms. Our result warrant that LLL is a very good therapy modality for children suffering from allergic rhinitis.

  20. Research update on the eosinophils and allergic disease%嗜酸粒细胞与变态反应性疾病的研究进展

    Institute of Scientific and Technical Information of China (English)

    刘轲; 刘月辉

    2012-01-01

    The incidence of allergic diseases(asthma. allergic rhinitis, atopic dermatitis and food allergy) increased gradually over recent decades, and an increasing number of patients are suffering from allergic diseases. thus the rise in allergic disease incidence warrants concern. Researchers have already had a deeper understanding of the pathogenesis of allergic diseases. Mounting evidence has shown that the eosinophils play an important role in the pathogenesis of allergic diseases. Many systematic studies have been conducted about eosinophils, therefore, this review will provide a summary on recent progress in eosinophils and allergic diseases.