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Sample records for allergic rhinitis patients

  1. Heart Rate Variability Analysis in Patients with Allergic Rhinitis

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    Ming-Ying Lan

    2013-01-01

    Full Text Available Background. Very few studies investigate the role of the autonomic nervous system in allergic rhinitis. In this study, we evaluated the autonomic nervous system in allergic rhinitis patients using heart rate variability (HRV analysis. Methods. Eleven patients with allergic rhinitis and 13 healthy controls, aged between 19 and 40 years old, were enrolled in the study. Diagnosis of allergic rhinitis was based on clinical history, symptoms, and positive Phadiatop test. Electrocardiographic recordings on the sitting and supine positions were obtained for HRV analysis. Results. In the supine position, there were no significant statistical differences in very-low-frequency power (VLF, ≤0.04 Hz, low-frequency power (LF, 0.04–0.15 Hz, high-frequency power (HF, 0.15–0.40 Hz, and the ratio of LF to HF (LF/HF between the patient and control groups. The mean RR intervals significantly increased, while LF% and LF/HF significantly decreased in the patient group in the sitting position. Moreover, mean RR intervals, LF, and LF/HF, which were significantly different between the two positions in the control group, did not show a significant change with the posture change in the patient group. Conclusion. These suggest that patients with allergic rhinitis may have poor sympathetic modulation in the sitting position. Autonomic dysfunction may therefore play a role in the pathophysiology of allergic rhinitis.

  2. Frequency of Mold Allergens in Allergic Rhinitis Patients

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    Bonyadi, MR. (PhD

    2014-06-01

    Full Text Available Background and Objective: Allergic rhinitis can be stimulated by several allergens. Molds are among these allergens and it is important to assess their frequency in different geographic area. Hence, we aimed at determining the frequency of mold allergens in allergic rhinitis patients referred to specialized clinics of Tabriz Imam Reza hospital, 2011. Material and Methods: This cross-sectional study was conducted on the serums of 90 rhinitis patients diagnosed by specialized physician. Using Immunoblotting method, the level of specific IgE against four molds including Penicillium, Aspergillus, Alternaria and Cladosporium were investigated. Results: Of 90 Patients, 40 were men (44.4% and 50 were women (55.6%. The participants were between 6 to 53 years and the most were 28-31years. The allergy was related to Penicillium (3.3%, Aspergillus (5.6%, Alternaria (13.3% and Cladosporium (4.4%. There was a significant statistical relation between age and allergic rhinitis to Alternaria (P=0.011. Conclusion: Molds can grow and proliferate in very humid environments. Because of low humidity climate in Tabriz (in the northwest of Iran, allergy to molds is relatively low in this region. Key words: Rhinitis Allergic; Mold; Allergy

  3. The Prevalence of Allergic Rhinitis in Patients with Chronic Rhinosinusitis

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    Mehdi Bakhshaee

    2014-10-01

    Full Text Available Introduction: Chronic rhinosinusitis (CRS is a multifactorial disease. Allergies are considered a predisposing factor to CRS; however, this remains controversial. The objective of this research was to investigate the prevalence of co-morbidities and allergic reaction, and to specify the most common allergens in patients with confirmed CRS.   Materials and Methods: One hundred patients with signs and symptoms of CRS who met the diagnostic endoscopic and radiologic criteria of chronic rhinosinusitis were selected. They filled out a questionnaire and underwent a skin prick test for the common inhalant allergens. Allergic rhinitis was diagnosed according to the history and positive skin prick tests.   Results: The mean age of patients was 34. Males were slightly more involved (54%. The prevalence of polypoid and none-polypoid rhinosinusitis was 54% and 46% respectively. The patients’ most common symptoms were nasal discharge (95%, blockage (94%, smell disorders (63%, cough (45%, halitosis (41%, lethargy (37%, and aural fullness (36%. Allergy to at least one allergen was noted in 64% of the CRS patients which is higher than general population in Mashhad, Iran with allergic rhinitis (22.4%. Salsola was the most common allergen. There was no significant difference in allergic reactions between polypoid and non-polypoid CRS patients.   Conclusion:  Allergic reactions was found in Iranian CRS patients with or without polyposis to be much higher than general population in Mashhad with allergic rhinitis alone.

  4. Physician and patient survey of allergic rhinitis: methodology.

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    Higgins, V; Kay, S; Small, M

    2007-01-01

    Methodology for Disease Specific Programme (DSP) surveys designed by Adelphi Group Products is used each year to survey patients and physicians on their perceptions of treatment effectiveness, symptoms and impact of diseases. These point-in-time surveys, conducted in the USA and Europe (France, Germany, Italy, Spain and UK), provide useful information on the real-world management and treatment of diseases. This paper describes the methodology for the DSP survey in allergic rhinitis, detailing the preparation of materials, recruitment of physicians, data collection and data management.

  5. Nasal hemophilic pseudotumor in a patient with mild hemophilia A and allergic rhinitis.

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    Ogata, Yoshiyasu; Monji, Mikio; Kai, Keita; Matsuo, Muneaki

    2017-02-01

    Hemophilic pseudotumor is a rare complication, even in patients with severe hemophilia. Herein we report on a case of hemophilic pseudotumor in a patient with mild hemophilia A and allergic rhinitis, initially suspected to be a nasal tumor. The pseudotumor was cured by supplementation with recombinant factor VIII concentrates, and medication for allergic rhinitis. Pseudotumor should always be considered in hemophiliac patients, even in those with only mild deficiency of coagulation factors.

  6. Pediatric allergic conjunctivitis and allergic rhinitis

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    Tong Qiao; Yizhen Hu; Zhinan Wang

    2008-01-01

    Objective: To assess the relationship between allergic conjunctivitis(AC) and allergic rhinitis(AR) in pediatric ophthalmology and E.N.T outpatient clinic. Methods:Eight hundred and ninety two patients were enrolled in survey during Mar. 2005~Jan. 2007, 407 allergic conjunctivitis cases were placed in the ophthalmology clinic group and 485 allergic rhinitis cases were from the E.N.T clinic.The comorbid disorders, histories, symptoms, signs of patients were recorded. Type 1 allergy was tested in 479 cases by a specific IgE antibody blood test. Eosinophils were detected in superficial conjunctival scrapings of the superior tarsal conjunctiva and mucosa surface scrapings of middle nasal meatus in 88 cases with both diseases. Results:302(74%), 374(92%), 116(29%) in 407 cases with allergic conjunctivitis had concomitant eczema, rhinitis and asthma, respectively; 334(69%), 430(89%), 145(30%) in 485 cases with allergic rhinitis had concomitant eczema, allergic conjunctivitis and asthma, respectively. The prevalence of allergic conjunctivitis concomitant allergic rhinitis and allergic rhinitis concomitant allergic conjunctivitis had no significant difference(x2=2.6, P>0.05). The prevalence of allergic conjunctivitis and allergic rhinitis concomitant eczema and asthma also had no significant difference (x2=3.08; x2=0.21, P>0.05). The degree of severity of two kinds of disease symptoms is not parallel, in the patients with seasonal allergic conjuctivitis(SAC) and perennial allergic conjunctivitis(PAC), the clinical signs of AR were always severer(x2=258.2, P<0.05)than those of AC. However, the results coincided with the cases with vernal keratoconjuctivitis(VKC)(x2=66.5, P<0.05); Eosinophils were revealed in 50(57%) conjunctival scrapings and nasal mucosa scrapings(x2=1.5, P>0.05), 47(53%) cases had positive results in both scrapings. The main aeroallergens were house dust mites, house dust and fungi, and the main food-allergens were fish, crab and shrimp

  7. Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study

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    Luukkainen Annika

    2011-12-01

    Full Text Available Abstract Background Indoleamine 2,3-dioxygenase (IDO is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. Objective Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis patients allergic to birch pollen during peak exposure to birch pollen allergen and compare it to non-atopic patients. Methods IDO expression was immunohistochemically evaluated from nasal specimens obtained in- and off-season from otherwise healthy non-smoking volunteers both allergic to birch pollen (having mild or moderate allergic rhinoconjunctivitis and non-allergic controls. Results: The IDO expression levels were low in healthy controls and remained low also in patients allergic to birch pollen. There were no differences in the expression of IDO in- and off-season in either healthy or allergic subjects. Conclusions There is a controversy in the role of IDO in upper and lower airways during allergic airway disease. It seems that IDO is associated to allergic inflammations of the lower airways, but does not have a local role in the nasal cavity at least in mild or moderate forms of allergic rhinitis.

  8. Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients

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    Zhao Changqing

    2011-07-01

    Full Text Available Abstract Background The association between sensitizations and severity of allergic diseases is controversial. Objective This study was to investigate the association between severity of asthma and rhinitis and degree of specific allergic sensitization in allergic patients in China. Method A cross-sectional survey was performed in 6304 patients with asthma and/or rhinitis from 4 regions of China. Patients completed a standardized questionnaire documenting their respiratory and allergic symptoms, their impact on sleep, daily activities, school and work. They also underwent skin prick tests with 13 common aeroallergens. Among the recruited subjects, 2268 provided blood samples for serum measurement of specific IgE (sIgE against 16 common aeroallergens. Results Significantly higher percentage of patients with moderate-severe intermittent rhinitis were sensitized to outdoor allergens while percentage of patients sensitized to indoor allergens was increased with increasing severity of asthma. Moderate-severe intermittent rhinitis was associated with the skin wheal size and the level of sIgE to Artemisia vulgaris and Ambrosia artemisifolia (p Dermatophagoides (D. pteronyssinus and D. farinae (p Conclusions Artemisia vulgaris and Ambrosia artemisifolia sensitizations are associated with the severity of intermittent rhinitis and D. pteronyssinus and D. farinae sensitizations are associated with increasing severity of asthma in China. Increase in number of allergens the patients are sensitized to may also increase the severity of rhinitis and asthma.

  9. Selecting the optimal oral antihistamine for patients with allergic rhinitis.

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    Lehman, Jeffrey M; Blaiss, Michael S

    2006-01-01

    Allergic rhinitis (AR) is now recognised as a global health problem that affects 10-30% of adults and up to 40% of children. Each year, millions of patients seek treatment from their healthcare provider. However, the prevalence of AR maybe significantly underestimated because of misdiagnosis, under diagnosis and failure of patients to seek medical attention. In addition to the classical symptoms such as sneezing, nasal pruritus, congestion and rhinorrhoea, it is now recognised that AR has a significant impact on quality of life (QOL). This condition can lead to sleep disturbance as a result of nasal congestion, which leads to significant impairment in daily activities such as work and school. Traditionally, AR has been subdivided into seasonal AR (SAR) or perennial AR (PAR). SAR symptoms usually appear during a specific season in which aeroallergens are present in the outdoor air such as tree and grass pollen in the spring and summer and weed pollens in the autumn (fall); and PAR symptoms are present year-round and are triggered by dust mite, animal dander, indoor molds and cockroaches. Oral histamine H(1)-receptor antagonists (H(1) antihistamines) are one of the most commonly prescribed medications for the treatment of AR. There are several oral H(1) antihistamines available and it is important to know the pharmacology, such as administration interval, onset of action, metabolism and conditions that require administration adjustments. When prescribing oral H(1) antihistamines, the healthcare provider must take into account the clinical efficacy and weigh this against the risk of adverse effects from the agent. In addition to the clinical efficacy, potential for improvement in QOL with a particular treatment should also be considered.

  10. Japanese Guideline for Allergic Rhinitis

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    Kimihiro Okubo; Yuichi Kurono; Shigeharu Fujieda; Satoshi Ogino; Eiichi Uchio; Hiroshi Odajima; Hiroshi Takenaka; Kohtaro Baba

    2011-01-01

    Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. In Japan, the first guideline was prepared after a symposium held by the Japanese Society of Allergology in 1993. The current 6th editi...

  11. Comparison of Acoustic and Stroboscopic Findings and Voice Handicap Index between Allergic Rhinitis Patients and Controls

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    Koç, Eltaf Ayça Özbal; Koç, Bülent; Erbek, Selim

    2014-01-01

    Background: In our experience Allergic Rhinitis (AR) patients suffer from voice problems more than health subjects. Aims: To investigate the acoustic analysis of voice, stroscopic findings of larynx and Voice Handicap Index scores in allergic rhinitis patients compared with healthy controls. Study Design: Case-control study. Methods: Thirty adult patients diagnosed with perennial allergic rhinitis were compared with 30 age- and sex-matched healthy controls without allergy. All assessments were performed in the speech physiology laboratory and the testing sequence was as follows: 1. Voice Handicap Index (VHI) questionnaire, 2. Laryngovideostroboscopy, 3. Acoustic analyses. Results: No difference was observed between the allergic rhinitis and control groups regarding mean Maximum Phonation Time (MPT) values, Fo values, and stroboscopic assessment (p>0.05). On the other hand, mean VHI score (p=0.001) and s/z ratio (p=0.011) were significantly higher in the allergic rhinitis group than in controls. Conclusion: Our findings suggest that the presence of allergies could have effects on laryngeal dysfunction and voice-related quality of life. PMID:25667789

  12. Assessment of sensitization to insect aeroallergens among patients with allergic rhinitis in Yazd City, Iran.

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    Mohammad Hassan Bemanian

    2012-09-01

    Full Text Available The  frequency of  allergic diseases such  as allergic rhinitis is considerable in general population. Insect aeroallergens are important allergens which can induce airway inflammation. The aim of this study was to determine the prevalence of sensitization to insect aeroallergens in allergic rhinitis patients in Yazd as a desert city in Iran.A cross-sectional study was undertaken on 95 allergic rhinitis patients who were referred to allergy clinic of Yazd city. Skin prick tests (SPT by standard extracts of three insect aeroallergens including Mosquito,  Corn  moth,  Cockroach  and  two  species of  mites  as common  aeroallergens in allergic rhinitis (Dermatophagoid  Farina, Dermatophagoid Peteronysinus were done.SPT results showed that the most common insect aeroallergens were: mosquito (32.6% followed by corn  moth  (26.3% and cockroach (13.7%.The prevalence of SPT positive response to Dermatophagoid Peteronysinus, Dermatophagoid Farina were 8.4% and 7.4%, respectively. These  results  demonstrated  that  sensitization  to  insect  aeroallergens was significantly more common compared to mites in patients with allergic rhinitis in Yazd city, a city surrounded by deserts.High prevalence of skin reactivity to mosquito and corn moth as insect aeroallergens in Yazd city with hot and dry climate in contrast to humid regions such as north of Iran, where mites are more frequent, indicates differences in the prevalence of aeroallergen reactivity in various areas with different climates. Our  study could highlight the importance of insect aeroallergens for clinicians for better  diagnosis and management of patients with allergic rhinitis.

  13. Allergic Rhinitis: Mechanisms and Treatment.

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    Bernstein, David I; Schwartz, Gene; Bernstein, Jonathan A

    2016-05-01

    The prevalence of allergic rhinitis (AR) has been estimated at 10% to 40%, and its economic burden is substantial. AR patients develop specific immunoglobulin E (IgE) antibody responses to indoor and outdoor environmental allergens with exposure over time. These specific IgE antibodies bind to high-affinity IgE receptors on mast cells and basophils. Key outcome measures of therapeutic interventions include rhinitis symptom control, rescue medication requirements, and quality-of-life measures. A comprehensive multiple modality treatment plan customized to the individual patient can optimize outcomes.

  14. Evaluation of effectiveness of specific subcutaneous immunotherapy for patients with allergic rhinitis and asthma

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    Mohammad Reza Zandkarimi

    2013-06-01

    Full Text Available Background: Allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with IgE-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. This study evaluated the clinical efficacy of immunotherapy with extracts of common aeroallergens North-East of Iran in asthma and allergic rhinitis. Material and Methods: In this prospective study 156 cases were chosen randomley. The mean age of patients was 37 years (range 5-65 years. The patients with mild to moderate asthma and allergic rhinitis and history of atopy were selected for immunotherapy when they showed no effective response to medical treatment.Immunotherapy materials were made from common aeroallergens in north-eastern region of Iran by Dome Hollister US company. Immunotherapy schedule for injection of the extract with vial dilution of 1:10000pg was one injection every week for ten weeks and one injection with dilution of 1:1000pg every other week for the other ten weeks and one injection monthly from dilution of 1:100pg for two years. Results: One hundred twenty (77% of cases had allergic rhinitis 29(18.5% cases had allergic asthma and 7(4.5% cases were mixed. Mean age of patients were 37 years old. 48(30.8% cases were male. Analysis of efficacy of treatment showed that immunotherapy significantlyimproved the signs and symptoms of all the groups. In allergic rhinitis group 84(70% cases completely improved, 22(18.4% patients moderately responded and no response to immunotherapy was observed in 14(11.6% patients. In allergic asthma group, 22(75% cases completely improved 4(13.6% cases moderately responded and no response to immunotherapy was detected in 3(11.4% cases. In mixed group, 3(42.8% cases completely improved, 3(42.8% cases moderately responded and no response was observed in 1(14.4% case. Conclusion: Specific allergen immunotherapy for patients with allergic persistent

  15. [Definition and clinic of the allergic rhinitis].

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    Spielhaupter, Magdalena

    2016-03-01

    The allergic rhinitis is the most common immune disorder with a lifetime prevalence of 24% and one of the most common chronic diseases at all--with tendency to rise. It occurs in childhood and influences the patients' social life, school performance and labour productivity. Furthermore the allergic rhinitis is accompanied by a lot of comorbidities, including conjunctivitis, asthma bronchiale, food allergy, neurodermatitis and sinusitis. For example the risk for asthma is 3.2-fold higher for adults with allergic rhinitis than for healthy people.

  16. COMPARISON OF PARTIAL INFERIOR TURBINECTOMY AND SUBMUCOSAL DIATHERMY FOR HYPERTROPHIED INFERIOR TURBINATE IN ALLERGIC RHINITIS PATIENTS

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    Smitha Chandra

    2015-07-01

    Full Text Available BACKGROUND : The inferior turbinate is the first point of contact of allergen in the nose. In patients with allergic rhinitis the turbinate hypertrophies and its mucosa becomes purplish edematous. This leads to significant obstruction of airway. Hence reduction of this hypertrophied inferior turbinate is essential. AIM: To analyze & evaluate the efficacy of sub mucosal diathermy and partial inferior turbinectomy in the treatment of symptomatic hypertrophied inferior turbinates in allergic rhinitis patients in a rural setup. METHODS AND MATERIAL S: A prospective clinical study of 132 patients between age group of 15 - 55 years of eith er sex were enrolled in the study with bilateral Inferior. Turbinate Hypertrophy who had history of failed medical line of treatment. After informing , the patients were randomized into two groups to eliminate bias byallotting them alternately into the groups. Patients in Group I underwent. Submucosal diathermy and Group II patients underwent Partial Inferior. Turbinectomy. Postoperative follow up was done at regular intervals by objective& subjective assessment. STATISTICAL ANALYSIS USED: Friedman test and Ch i Square test were used for statistical analysis. RESULTS: In group I significant improvement of nasal airflow was seen in 14% patients & 85.9% had moderate improvement. In group II 41.3% of patients had significant improvement & 58.6% had moderate i mprovement. Statistically by analyzing the ranks of subjective nasal obstruction and objective nasal obstruction of Group - I & Group - IIwe conclude that Group - II subjects showed more improvement than Group I. CONCLUSIONS: Various surgical methods have been t ried for enlarged inferior turbinate secondary to allergic rhinitis. Of them the well - known techniques are s ubmucosal Diathermy & Partial Inferior Turbinectomy. In this study Partial Inferior Turbinectomy was found to be more effective in relieving nasal ob structionin allergic rhinitis patients for

  17. Cytotoxic T lymphocytes mediate chronic inflammation of the nasal mucosa of patients with atypical allergic rhinitis

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    Shuqi Qiu

    2011-01-01

    Full Text Available Background : The prevalence of chronic rhinitis is increasing rapidly; its pathogenesis is to be further understood; immune inflammation is one of the possible causative factors. Antigen specific CD8+ T cells play a critical role in the induction of chronic inflammation. Aims : This study aimed to investigate the role of antigen specific CD8+ T cells in the pathogenesis of chronic atypical allergic rhinitis. Material and Methods : Nasal mucosal epithelial surface scratching samples were obtained from patients with chronic obstruction atypical allergic rhinitis. Exosomes were purified from the scratching samples and examined by immune gold electron microscopy. The effect of exosomes on modulating dendritic cell′s properties, the effect of exosome-pulsed dendritic cells on naïve T cell differentiation and the antigen specific CD8+ T cell activation were observed by cell culture models. Results : Exosomes purified from patients with chronic atypical allergic rhinitis carried microbial products, Staphylococcal enterotoxin B (SEB, and airborne antigen, Derp1. Dendritic cells pulsed by SEB/Derp1-carrying exosomes showed high levels of CD80, CD86 and the major histocompatibility class I (MHCI. Exosome-pulsed dendritic cells could induce the naïve CD3+ T cells to differentiate into CD8+ T cells. Upon the exposure to a specific antigen, the CD8+ T cells released granzyme B and perforin; more than 30% antigen specific CD8+ T cells proliferated. Conclusions : Antigen specific CD8+ T cells play an important role in the pathogenesis of chronic obstruction atypical allergic rhinitis.

  18. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients.

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    Mao, T K; Van de Water, J; Gershwin, M E

    2005-01-01

    Spirulina represents a blue-green alga that is widely produced and commercialized as a dietary supplement for modulating immune functions, as well as ameliorating a variety of diseases. We have previously shown that the in vitro culture of Spirulina with human peripheral blood mononuclear cells (PBMCs) modulated the production of cytokines. In the present study, we evaluated the impact of a Spirulina-based dietary supplement (Earthrise Nutritionals, Inc., Irvine, CA) on patients with allergic rhinitis by assessing the production of cytokines [interleukin (IL)-4, interferon (IFN)-gamma, and IL-2] critical in regulating immunoglobulin E-mediated allergy. In a randomized double-blinded crossover study versus placebo, allergic individuals were fed daily with either placebo or Spirulina, at 1,000 mg or 2,000 mg, for 12 weeks. PBMCs isolated before and after the Spirulina feeding were stimulated with phytohemagglutinin (PHA) prior to determining the levels of cytokine from cell culture supernatants. Although Spirulina seemed to be ineffective at modulating the secretion of Th1 cytokines (IFN-gamma and IL-2), we discovered that Spirulina, administered at 2,000 mg/day, significantly reduced IL-4 levels by 32% from PHA-stimulated cells. These results indicate that Spirulina can modulate the Th profile in patients with allergic rhinitis by suppressing the differentiation of Th2 cells mediated, in part, by inhibiting the production of IL-4. To our knowledge, this is the first human feeding study that demonstrates the protective effects of Spirulina towards allergic rhinitis.

  19. Japanese guidelines for allergic rhinitis 2017

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    Kimihiro Okubo

    2017-04-01

    To incorporate evidence based medicine (EBM introduced from abroad, the most recent collection of evidence/literature was supplemented to the Practical Guideline for the Management of Allergic Rhinitis in Japan 2016. The revised guideline includes assessment of diagnosis/treatment and prescriptions for children and pregnant women, for broad clinical applications. An evidence-based step-by-step strategy for treatment is also described. In addition, the QOL concept and cost benefit analyses are also addressed. Along with Allergic Rhinitis and its Impact of Asthma (ARIA, this guideline is widely used for various clinical purposes, such as measures for patients with sinusitis, childhood allergic rhinitis, oral allergy syndrome, and anaphylaxis and for pregnant women. A Q&A section regarding allergic rhinitis in Japan was added to the end of this guideline.

  20. Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history.

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    Gelardi, M; Iannuzzi, L; Tafuri, S; Passalacqua, G; Quaranta, N

    2014-02-01

    Rhinitis and rhinosinusitis (with/without polyposis), either allergic or non-allergic, represent a major medical problem. Their associated comorbidities and relationship with family history have so far been poorly investigated. We assessed these aspects in a large population of patients suffering from rhinosinusal diseases. Clinical history, nasal cytology, allergy testing and direct nasal examination were performed in all patients referred for rhinitis/rhinosinusitis. Fibre optic nasal endoscopy, CT scan and nasal challenge were used for diagnosis, when indicated. A total of 455 patients (60.7% male, age range 4-84 years) were studied; 108 (23.7%) had allergic rhinitis, 128 (28.1%) rhinosinusitis with polyposis, 107 (23.5%) non-allergic rhinitis (negative skin test); 112 patients had associated allergic and non-allergic rhinitis, the majority with eosinophilia. There was a significant association between non-allergic rhinitis and family history of nasal polyposis (OR = 4.45; 95%CI = 1.70-11.61; p = 0.0019), whereas this association was no longer present when allergic rhinitis was also included. Asthma was equally frequent in non-allergic and allergic rhinitis, but more frequent in patients with polyposis. Aspirin sensitivity was more frequent in nasal polyposis, independent of the allergic (p = 0.03) or non-allergic (p = 0.01) nature of rhinitis. Nasal polyposis is significantly associated with asthma and positive family history of asthma, partially independent of the allergic aetiology of rhinitis.

  1. Atopic Manifestations: Dermatitis, Allergic Rhinitis and Asthma in Patients With Hypogammaglobulinemia

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    Minoo Dadkhah

    2015-10-01

    Full Text Available Background: Most of the hypogammaglobulinemic patients have a clinical history in favor of allergic respiratory disease. Nevertheless, in these patients the importance and prevalence of atopic disorders have not been completely explained. Objectives: This study was aimed to evaluate atopic manifestations (dermatitis, allergic rhinitis and asthma and pulmonary function in patients with hypogammaglobulinemia. Patients and Methods: We used the international study of asthma and allergies in childhood (ISAAC questionnaire in forty-five patients diagnosed with hypogammaglobulinemia and spirometry was done in 41 patients older than 5 years. Results: Spirometry results were normal in 21 (51%, and showed obstructive in 15 (37% and restrictive pattern in 5 (12% of the 41 patients who were evaluated. By the end of the study, asthma was diagnosed in nine (20% patients and other atopies (rhinitis and dermatitis identified in 10 (22%, and four (9%, respectively. Conclusions: Atopic conditions should be investigated in the hypogammaglobulinemic patients and the prevalence in these patients may be higher than in normal population. Also, it is recommended to perform a pulmonary function test as a routine procedure in patients with hypogammaglobulinemia and atopy should be assessed in these patients.

  2. SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms

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    Mosbech, Holger; Canonica, G Walter; Backer, Vibeke;

    2015-01-01

    BACKGROUND: House dust mite (HDM) allergy is associated with persistent allergic rhinitis (AR) and allergic asthma. OBJECTIVE: To investigate the efficacy and safety of a SQ HDM sublingually administered immunotherapy tablet (ALK, Hørsholm, Denmark) in adults and adolescents with HDM respiratory ...

  3. Allergic Rhinitis in Childhood - Review

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    Arzu Babayiğit

    2010-12-01

    Full Text Available Allergic rhinitis, an immunoglobulin E mediated disease, is the most common chronic allergic childhood disease. The disease is characterized by nasal sneezing, rhinorrhea, palate and eye itchiness, and congestion and it can significantly impact children’s health. It causes uncomfortable symptoms, impairs quality of life and can predispose to the development of comorbidities such as asthma. Etiological diagnosis is based on cutaneous prick tests, which have a high sensitivity and specificity rate and which can be easily applied to young children. Treatment initially involves avoidance measures and, when necessary, pharmacotherapy or immunotherapy. Pharmacotherapy generally involves antihistamines and/or nasal corticosteroids, but leukotriene antagonists have also demonstrated effectiveness in treating allergic rhinitis symptoms. In this article, the symptoms, diagnosis and treatment of allergic rhinitis in childhood are discussed. (Journal of Current Pediatrics 2010; 8: 105-12

  4. Treating allergic rhinitis in pregnancy.

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    Piette, Vincent; Daures, Jean-Pierre; Demoly, Pascal

    2006-05-01

    Numerous pregnant women suffer from allergic rhinitis, and particular attention is required when prescribing drugs to these patients. In addition, physiologic changes associated with pregnancy could affect the upper airways. Evidence-based guidelines on the management of allergic rhinitis have been published. Medication can be prescribed during pregnancy when the apparent benefit of the drug is greater than the apparent risk. Usually, there is at least one "safe" drug from each major class used to control symptoms. All glucocorticosteroids are teratogenic in animals but, when the indication is clear (for diseases possibly associated, such as severe asthma exacerbation), the benefit of the drug is far greater than the risk. Inhaled glucocorticosteroids (eg, beclomethasone or budesonide) have not been incriminated as teratogens in humans and are used by pregnant women who have asthma. A few H1-antihistamines can safely be used as well. Most oral decongestants (except pseudoephedrine) are teratogenic in animals. There are no such data available for intranasal decongestants. Finally, pregnancy is not considered to be a contraindication for the continuation of immunotherapy.

  5. Understanding the role of the healthcare professional in patient self-management of allergic rhinitis

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    Bonnie L Kuehl

    2015-08-01

    Full Text Available Objective: Allergic rhinitis is a common, usually long-standing, condition that may be self-diagnosed or have a formal diagnosis. Our aim was to identify how allergic rhinitis sufferers self-manage their condition. Methods: A sample of 276 self-identified adult allergy sufferers pooled from social media completed an online survey comprising 13 questions. The survey was fielded by a professional research organization (Lab42. The main outcome measures included the use of prescription and/or non-prescription allergy medication, and interactions with physician and/or pharmacist with respect to medication use. Results: Of the respondents, 53% (146/276 indicated that they used both prescription and over-the-counter medication to manage their allergy symptoms. Of those who used prescription medication, 53% reported that they discussed their prescription medication in great detail with their physician when it was prescribed, while 42% spoke about it briefly. Following the initial prescription, few discussions about the prescription occur with the physician (45% indicate several discussions, 40% indicate one or two discussions, and 10% indicate no discussions. In most cases (~75% of the time, allergy prescription refills did not require a doctor visit with patients obtaining refills through phone calls to the doctor’s office or through the pharmacy. Two-thirds of patients (69% report that they have discussed their prescription allergy medication with a pharmacist, with greater than half of respondents having discussed the use of the non-prescription medication with their doctor. Conclusion: Patients with diagnosed allergic rhinitis appear to be self-managing their condition with few interactions with their doctor about their allergy prescription. Interactions with a pharmacist about allergy medication (prescription and non-prescription appear to be more common than interactions with a physician.

  6. 5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: a real-life study

    Directory of Open Access Journals (Sweden)

    Pastorello EA

    2013-12-01

    Full Text Available Elide Anna Pastorello,1 Laura Losappio,1 Stefania Milani,2 Giuseppina Manzotti,3 Valentina Fanelli,4 Valerio Pravettoni,5 Fabio Agostinis,6 Alberto Flores D’Arcais,7 Ilaria Dell'Albani,8 Paola Puccinelli,9 Cristoforo Incorvaia,10 Franco Frati81Allergy and Immunology Department, Niguarda Hospital, Milan, 2Allergy Department, San Marco General Hospital, Bergamo, 3Allergy Department, Treviglio Hospital, Bergamo, 4Allergy Department, Italian Institute for Auxology, Milan, 5Clinical Allergy and Immunology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, 6Department of Pediatrics, Riuniti Hospital, Bergamo, 7Department of Pediatrics, Legnano Hospital, Milan, 8Medical and Scientific Department, Stallergenes Italy, Milan, 9Regulatory Department, Stallergenes Italy, Milan, 10Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyBackground: An important subpopulation in allergic rhinitis is represented by patients with severe form of disease that is not responsive to drug treatment. It has been reported that grass pollen subcutaneous immunotherapy is effective in drug-resistant patients. In a real-life study, we evaluated the efficacy of 5-grass pollen tablets in patients with grass pollen-induced allergic rhinitis not responsive to drug therapy.Methods: We carried out this multicenter observational study in adults and adolescents with grass-induced allergic rhinitis not responsive to drug therapy who were treated for a year with 5-grass pollen tablets. Clinical data collected before and after sublingual immunotherapy (SLIT included Allergic Rhinitis and its Impact on Asthma (ARIA classification of allergic rhinitis, response to therapy, and patient satisfaction.Results: Forty-seven patients entered the study. By ARIA classification, three patients had moderate to severe intermittent allergic rhinitis, ten had mild persistent allergic rhinitis, and 34 had moderate to severe persistent allergic rhinitis. There were no cases

  7. [Development of an add-on module for the WHOQOL-BREF on patients with allergic rhinitis].

    Science.gov (United States)

    Wang, Chiu-Hua; Maa, Suh-Hwa; Yang, Sien-Hung; Chen, Ying-Lin; Chen, Wei-Chun

    2008-06-01

    The purpose of this study was to develop an add-on module for the Taiwan-version WHOQOL-BREF for assessing the quality of life of people with allergic rhinitis. A cross-sectional survey design was used. In accordance with the seven steps for the development of population-specific modules of the WHOQOL, the instrument added new items on the basis of opinions of expert groups, including patients, families and physicians, to the Taiwan-version WHOQOL-BREF measure. The new questionnaire, comprising 52 items, was tested on 252 patients with allergic rhinitis. For content validity, each item was significantly correlated with the domain to which it belonged (r= .157-.715, pWHOQOL-BREF for patients with allergic rhinitis is reliable, valid and specific.

  8. Acupuncture Treatment of a Patient with Persistent Allergic Rhinitis Complicated by Rhinosinusitis and Asthma

    Directory of Open Access Journals (Sweden)

    Ae-Ran Kim

    2011-01-01

    Full Text Available A pathophysiologic relationship between allergic rhinitis and rhinosinusitis and asthma has long been suggested. However, few clinical studies of acupuncture have been conducted on these comorbid conditions. A 48-year-old male suffering from persistent allergic rhinitis with comorbid chronic rhinosinusitis and asthma since the age of 18 years was studied. He complained of nasal obstruction, sneezing, cough, rhinorrhea and moderate dyspnea. He occasionally visited local ear-nose-throat clinics for his nasal symptoms, but gained only periodic symptom relief. The patient was treated with acupuncture, infrared radiation to the face and electro-acupuncture. Needles were inserted at bilateral LI20, GV23, LI4 and EX-1 sites with De-qi. Electro-acupuncture was performed simultaneously at both LI20 sites and additional traditional Korean acupuncture treatments were performed. Each session lasted for 10 min and the sessions were carried out twice a week for 5 weeks. The patient’s Mini-Rhinoconjunctivitis Quality-of-Life Questionnaire score decreased from 38, at the beginning of treatment, to 23, 3 weeks after the last treatment. The Total Nasal Symptom Score was reduced from six (baseline to five, 3 weeks after the last treatment. There was significant clinical improvement in the forced expiratory volume in 1 s—from 3.01 to 3.50 l—with discontinuation of the inhaled corticosteroid, and no asthma-related complaints were reported. Further clinical studies investigating the effectiveness of acupuncture for the patients suffering from allergic rhinitis and/or rhinosinusitis with comorbid asthma are needed.

  9. The effects of spirulina on allergic rhinitis.

    Science.gov (United States)

    Cingi, Cemal; Conk-Dalay, Meltem; Cakli, Hamdi; Bal, Cengiz

    2008-10-01

    The prevalence of allergic rhinitis is increasing globally due to various causes. It affects the quality life of a large group of people in all around the world. Allergic rhinitis still remains inadequately controlled with present medical means. The need of continuous medical therapy makes individuals anxious about the side effects of the drugs. So there is a need for an alternative strategy. Effects of spirulina, tinospora cordifolia and butterbur were investigated recently on allergic rhinitis in just very few investigations. Spirulina represents a blue-green alga that is produced and commercialized as a dietary supplement for modulating immune functions, as well as ameliorating a variety of diseases. This double blind, placebo controlled study, evaluated the effectiveness and tolerability of spirulina for treating patients with allergic rhinitis. Spirulina consumption significantly improved the symptoms and physical findings compared with placebo (P Spirulina is clinically effective on allergic rhinitis when compared with placebo. Further studies should be performed in order to clarify the mechanism of this effect.

  10. Japanese Guideline for Allergic Rhinitis 2014

    OpenAIRE

    Kimihiro Okubo; Yuichi Kurono; Shigeharu Fujieda; Satoshi Ogino; Eiichi Uchio; Hiroshi Odajima; Hiroshi Takenaka

    2014-01-01

    Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. In Japan, the first guideline was prepared after a symposium held by the Japanese Society of Allergology in 1993. The current 7th editi...

  11. Aetiology of allergic rhinitis in Hong Kong

    Directory of Open Access Journals (Sweden)

    Christopher W.K. Lam

    1998-01-01

    Full Text Available In a 1993 survey, allergic rhinitis was identified as the most common allergic disease in Hong Kong, affecting 29.1% of schoolchildren. Recently (1995, the International Study of Asthma and Allergies in Childhood (ISAAC also reported 44.5% current rhinitis among Hong Kong teenagers. Our objective was to study the aetiology of allergic rhinitis in Hong Kong using serological tests of allergen sensitization. In 57 allergic rhinitis patients and in the same number of age- and sex-matched controls the following were measured: serum total IgE, mixed aeroallergen IgE (Phadiatop™ and specific IgE versus house dust mite (HDM, cockroach, cat and dog dander, mould mixture (Penicillium, Cladosporium, Aspergillus and Alternaria species and four local pollens (Bermuda grass, Timothy, ragweed and mugwort. Compared with controls, allergic rhinitis patients (26 males, 31 females; mean (± SD age 25 ±11 years had a significantly elevated serum total IgE concentration (mean ± SEM: 496 ± 88 vs 179 ± 38 kU/L and an increased proportion of positive Phadiatop (95 vs 33% and specific IgE tests versus HDM (90 vs 44% and cockroach (42 vs 9%; Mann-Whitney U-test and χ2 tests all P < 0.005. There was no significant difference in sensitization to other allergens tested. House dust mite and cockroach are ubiquitous in Hong Kong with a warm, humid climate and crowded living conditions. Their identification as aetiological agents of allergic rhinitis should help in the development of environmental strategies for reducing the inhalant allergen load to prevent and control this prevalent and costly health problem in our community.

  12. The burden of allergic rhinitis (AR in Canada: perspectives of physicians and patients

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    Keith Paul K

    2012-06-01

    Full Text Available Abstract Background Allergic rhinitis (AR is a common problem and we sought to examine the burden of disease and its management in Canada from the perspectives of patients and physicians. Methods Two parallel, Canadawide structured telephone interviews surveyed 1,001 AR patients and 160 physicians in July 2006. Results 44% of patients had experienced nasal symptoms unrelated to a cold and 20% had a physician diagnosis of AR. At screening 27% reported asthma, 15% chronic or recurrent sinusitis and 5% nasal polyps. With attacks nasal congestion and runny nose were the most bothersome symptoms. Other problems experienced were fatigue (46%, poor concentration (32%, and reduced productivity (23%. Most (77% had not seen a physician in the past year. Physicians estimated they prescribed intranasal cortico steroids (INCS to most AR patients (77% consistent with guidelines but only 19% of patients had used one in the last month. Only 48% of patients were very satisfied with their current INCS. 41% of AR patients reported discontinuing their INCS with the most common reason being a perceived lack of long-lasting symptom relief (44%. 52% of patients felt that their current INCS lost effectiveness over 24 h. The most common INCS side effects included dripping down the throat, bad taste, and dryness. Most AR patients reported lifestyle limitations despite treatment (66%. 61% of patients felt that their symptoms were only somewhat controlled or poorly/not controlled during their worst month in the past year. Conclusions AR symptoms are common and many patients experience inadequate control. Physicians report they commonly prescribe intranasal corticosteroids, but patient’s perceived loss of efficacy and side effects lead to their discontinuation. Persistent relief of allergic rhinitis symptoms remains a major unmet need. Better treatments and education are required.

  13. Is Allergic Rhinitis a Factor That Affects Success of Tympanoplasty?

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    Elif Ersoy Callioglu

    2016-04-01

    Full Text Available Objective: The aim of the present study was to investigate the effect of allergic rhinitis on the success of the operation in chronic otitis surgery by using score for allergic rhinitis (SFAR. Materials and Methods: In the present study; 121 patients, who underwent type 1 tympanoplasty were examined retrospectively. SFAR of all patients were recorded. The graft success rates of 26 patients with allergic rhinitis (AR and 95 patients with no allergic rhinitis group (NAR were compared. Results: While the graft success rate in NAR group was 89.5%, this rate was 80.8% in the AR group. However, the difference between groups was not statistically significant (p = 0.311. Conclusion: These findings suggest that allergic rhinitis decreases the graft success rate of the pathologies occurring in eustachian tube, middle ear and mastoid although statistically significant difference wasn’t found. Prospective studies with larger patient groups are required in order to evaluate this pathology.

  14. Expression of HSP70 in Peripheral Lymphocytes of the Patients with Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    刘立思; 肖成峰; 张明; 程磊; 王鄂芬; 邬堂春

    2003-01-01

    The expression levels of heat shock protein 70 (HSP70) from peripheral lymphocytes ofthe patients with allergic rhinitis (AR) and the clinical implication were investigated. In the morn-ing, 3 ml of fasting venous blood was taken out. The lymphocytes were isolated by using Ficoll-Hypaque and the expression of HSP70 in the lymphocytes was detected by using Western blot. Inthe AR patients the HSP70 level (41.49± 15.77 integrated optical density, IOD) were significantlyhigher than that in the control group (23.89±10. 13 IOD, P<0.05). Western blot demonstratedthat HSP70 bands in AR patients were more intensive than those in the control group. It was con-cluded that the elevated HSP70 level in peripheral lymphocytes of the AR patients might contributeto the development of AR.

  15. STUDY OF PREVALENCE OF EOSINOPHILIA IN ALLERGIC RHINITIS

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    Ravi Kumar

    2015-10-01

    Full Text Available BACKGROUND: Allergic rhinitis is a common condition, though not life threatening, causes significant morbidity in terms of quality of life. Confirmation of allergen as etiological agent is cumbersome. Hence need for a simple test is vital and eosinophil parameters were looked at to answer the quest. AIM: To find out the prevalence of e osinophilia in Allergic rhinitis . To assess the value of nasal cytogram as an alternative investigation in diagnosing allergic rhinitis . MATERIALS & METHODS: Prospective study of 200 cases divided into two groups of 100 each was done. One group clinically with allergic rhinitis and other without. All cases had clinical examination after history was taken, Blood Absolute eosinophil count, Nasal smear for eosinophils done and assessed. RESULTS: Of the 200 patients examined in two groups of 100 each, mean age of allergic rhinitis patients was 26.22 years . Allergic rhinitis was more common in males than females. Prevalence of nasal eosinophilia was 61%.and blood eosinophilia was 57% in allergic rhinitis patients. Nasal smear sensitivity was 61% and specificity w as 87% . CONCLUSION: Nasal smear eosinophilia is a valid test, can be quickly and easily performed and read. Being an in - expensive test can be used to screen the patients of allergic rhinitis

  16. Nasal hyperreactivity and inflammation in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    I. M. Garrelds

    1996-01-01

    Full Text Available The history of allergic disease goes back to 1819, when Bostock described his own ‘periodical affection of the eyes and chest’, which he called ‘summer catarrh’. Since they thought it was produced by the effluvium of new hay, this condition was also called hay fever. Later, in 1873, Blackley established that pollen played an important role in the causation of hay fever. Nowadays, the definition of allergy is ‘An untoward physiologic event mediated by a variety of different immunologic reactions’. In this review, the term allergy will be restricted to the IgE-dependent reactions. The most important clinical manifestations of IgE-dependent reactions are allergic conjunctivitis, allergic rhinitis, allergic asthma and atopic dermatitis. However, this review will be restricted to allergic rhinitis. The histopathological features of allergic inflammation involve an increase in blood flow and vascular permeability, leading to plasma exudation and the formation of oedema. In addition, a cascade of events occurs which involves a variety of inflammatory cells. These inflammatory cells migrate under the influence of chemotactic agents to the site of injury and induce the process of repair. Several types of inflammatory cells have been implicated in the pathogenesis of allergic rhinitis. After specific or nonspecific stimuli, inflammatory mediators are generated from cells normally found in the nose, such as mast cells, antigen-presenting cells and epithelial cells (primary effector cells and from cells recruited into the nose, such as basophils, eosinophils, lymphocytes, platelets and neutrophils (secondary effector cells. This review describes the identification of each of the inflammatory cells and their mediators which play a role in the perennial allergic processes in the nose of rhinitis patients.

  17. Links between allergic rhinitis and asthma

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Allergic diseases of the airway, which include seasonal rhinitis, chronic perennial rhinitis and asthma, are recognized as inflammatory disorders of the airway mucosa,1-3 but differ in the location of the inflammatory reaction and clinical manifestations of the disease. Asthma and allergic rhinitis frequently coexist in the same patient and are thought to share common predisposing genetic factors which interact with the environmental influences. Both diseases have increased in prevalence over recent decades4,5 particularly in westernized countries. This increase has been largely attributed to environmental factors such as exposure to aerial pollutants,4,6 and early life events, including the degree of exposure to infectious agents which might affect IgE production,5,7 since there has been insufficient time for a significant change in the gene pool.

  18. Remission of allergic rhinitis

    DEFF Research Database (Denmark)

    Bødtger, Uffe; Linneberg, Allan

    2004-01-01

    months and s-IgE levels of class 2 or greater against pollen (birch, grass, or mugwort). This was similar for AR to animals (cat or dog) or house dust mites (HDMs). Remission of AR was defined as AR at baseline but no rhinitis symptoms at follow-up and sensitization (s-IgE level class > or =2 at baseline...

  19. Treatment of allergic rhinitis during pregnancy.

    Science.gov (United States)

    Demoly, Pascal; Piette, Vincent; Daures, Jean-Pierre

    2003-01-01

    Allergic rhinitis is a frequent problem during pregnancy. In addition, physiological changes associated with pregnancy can affect the upper airways. Evidence-based guidelines on the management of allergic rhinitis have recently been published, the most recent being the Allergic Rhinitis and its Impact on Asthma (ARIA)--World Health Organization consensus. Many pregnant women experience allergic rhinitis and particular attention is required when prescribing drugs to these patients. Medication can be prescribed during pregnancy when the apparent benefit of the drug is greater than the apparent risk. Usually, there is at least one drug from each major class that can be safely utilised to control symptoms. All glucocorticosteroids are teratogenic in animals but, when the indication is clear (for diseases possibly associated, such as severe asthma exacerbation), the benefit of the drug is far greater than the risk. Inhaled glucocorticosteroids (e.g. beclomethasone or budesonide) have not been incriminated as teratogens in humans and are used by pregnant women who have asthma. A few histamine H(1)-receptor antagonists (H(1)-antihistamines) can safely be used as well. Most oral decongestants (except pseudoephedrine) are teratogenic in animals. There are no such data available for intra-nasal decongestants. Finally, pregnancy is not considered as a contraindication for the continuation of allergen specific immunotherapy.

  20. Study on Cytokines IL-2, IL-6, IL-10 in Patients of Chronic Allergic Rhinitis Treated with Acupuncture

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objectives: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. Methods: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). Results: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P<0.05). On the other hand, in those patients treated with sham acupuncture (B2) as well as in non-treated patients (B3), the IL-10 values remained high and unchanged. There was a statistically significant change in IL-2 values at 24 hours (P<0.05) after real acupuncture (Groups A, B1), however the values remained within normal ranges. The IL-6 do not change after therapy. Conclusion: The acupuncture treatment can reduce plasmatic level of IL-10 in chronic allergic rhinitis.

  1. Clinical Profile, Co-Morbidities and Health Related Quality of Life in Pediatric Patients with Allergic Rhinitis and Asthma

    OpenAIRE

    Keya R. Lahiri, Milind S. Tullu* and Rachna Kalra

    2010-01-01

    Background: Co-existence of allergic rhinitis (AR) and bronchial asthma (BA) is well known. We planned to study the clinical profile of patients with AR & BA, the associated co-morbidities and the effect of AR &/ or BA on health related quality of life (HRQOL) in Pediatric patients. Methods: Patients attending the Pediatric out-patients department and Pediatric Chest Clinic of tertiary care center were enrolled. The sample size included 100 subjects with BA & AR (Group 1) with control groups ...

  2. Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Seo Yeon Choi

    2016-01-01

    Full Text Available This study aimed to investigate the effects of aromatherapy oil inhalation on symptoms, quality of life, sleep quality, and fatigue level among adults with perennial allergic rhinitis (PAR. Fifty-four men and women aged between 20 and 60 were randomized to inhale aromatherapy oil containing essential oil from sandalwood, geranium, and Ravensara or almond oil (the placebo for 5 minutes twice daily for 7 days. PAR symptoms determined by Total Nasal Symptom Score (TNSS, the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ, sleep quality by Verran Synder-Halpern (VSH scale, and fatigue level by Chalder Fatigue Scale (CFS were assessed before and after intervention period. Compared with the placebo, the experimental group showed significant improvement in TNSS, especially in nasal obstruction. The aromatherapy group also showed significantly higher improvements in total score of RQLQ and CFS. These findings indicate that inhalation of certain aromatherapy oil helps relieve PAR symptoms, improve rhinitis-specific quality of life, and reduce fatigue in patients with PAR. In conclusion, inhalation of aromatherapy essential oil may have potential as an effective intervention to alleviate PAR.

  3. Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial.

    Science.gov (United States)

    Choi, Seo Yeon; Park, Kyungsook

    2016-01-01

    This study aimed to investigate the effects of aromatherapy oil inhalation on symptoms, quality of life, sleep quality, and fatigue level among adults with perennial allergic rhinitis (PAR). Fifty-four men and women aged between 20 and 60 were randomized to inhale aromatherapy oil containing essential oil from sandalwood, geranium, and Ravensara or almond oil (the placebo) for 5 minutes twice daily for 7 days. PAR symptoms determined by Total Nasal Symptom Score (TNSS), the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), sleep quality by Verran Synder-Halpern (VSH) scale, and fatigue level by Chalder Fatigue Scale (CFS) were assessed before and after intervention period. Compared with the placebo, the experimental group showed significant improvement in TNSS, especially in nasal obstruction. The aromatherapy group also showed significantly higher improvements in total score of RQLQ and CFS. These findings indicate that inhalation of certain aromatherapy oil helps relieve PAR symptoms, improve rhinitis-specific quality of life, and reduce fatigue in patients with PAR. In conclusion, inhalation of aromatherapy essential oil may have potential as an effective intervention to alleviate PAR.

  4. Bilastine: in allergic rhinitis and urticaria.

    Science.gov (United States)

    Carter, Natalie J

    2012-06-18

    Bilastine is an orally administered, second-generation antihistamine used in the symptomatic treatment of seasonal or perennial allergic rhinoconjunctivitis and urticaria. In two well designed phase III trials, 14 days' treatment with bilastine was associated with a significantly lower area under the effect curve (AUEC) for the reflective total symptom score (TSS) than placebo in patients with symptomatic seasonal allergic rhinitis. Additionally, reflective nasal symptom scores were significantly lower in bilastine than placebo recipients in patients with a history of seasonal allergic rhinitis who were challenged with grass pollen allergen in a single-centre, phase II study. Neither bilastine nor cetirizine was effective in the treatment of perennial allergic rhinitis with regard to the mean AUEC for reflective TSS in another well designed phase III trial. However, results may have been altered by differences in some baseline characteristics and placebo responses between study countries. In another well designed phase III trial, compared with placebo, bilastine was associated with a significantly greater change from baseline to day 28 in the mean reflective daily urticaria symptom score in patients with chronic urticaria. There were no significant differences in primary endpoint results between bilastine and any of the active comparators used in these trials (i.e. cetirizine, levocetirizine and desloratadine). Bilastine was generally well tolerated, with a tolerability profile that was generally similar to that of the other second-generation antihistamines included in phase III clinical trials.

  5. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis) : the new generation guideline implementation

    OpenAIRE

    Bousquet, J.; Schunemann, H J; Fonseca, J.; B. Samolinski; Bachert, C; Canonica, G. W.; Casale, T; Cruz, A A; P. Demoly; Hellings, P; Valiulis, A.; Wickman, M.; Zuberbier, T.; Bosnic-Anticevitch, S; Bedbrook, A.

    2015-01-01

    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Commu...

  6. [Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis].

    Science.gov (United States)

    Antépara, I; Jaúregui, I; Basomba, A; Cadahia, A; Feo, F; García, J J; Gonzalo, M A; Luna, I; Rubio, M; Vázquez, M

    1998-01-01

    The efficacy and safety of the nasally administered histamine H1 receptor blocking drug Azelastine was investigated in an open, multicenter, randomized comparative trial with Ebastine in seasonal allergic rhinitis. 110 patients in two parallel groups were treated for 14 days and efficacy was assessed by the physician using a rating scale measuring 10 nasal and ocular symptoms of seasonal rhinitis (0 = absent, 1 = mild, 2 = moderate, 3 = severe). Tolerability was measured on the basis of reported adverse events. Both treatment groups had dramatic reductions in the physician's total symptom score following treatment (p < 0.0005). There was no significant difference between the two groups. Changes in individual rhinitis symptoms showed no differences between the two groups. During treatment, 19 patients had at least one adverse event, 13 in Azelastine group and 6 in Ebastine group; all were mild. The most frequent adverse events reported were somnolence (4 cases in Ebastine group) and a bitter taste (4 patients in the Azelastine group). In conclusion, the results of the study on 110 patients suggest that both Azelastine and Ebastine are effective treatments of the symptoms of seasonal allergic rhinitis. Both drugs were well tolerated.

  7. Control of Allergic Rhinitis and Asthma Test (CARAT can be used to assess individual patients over time

    Directory of Open Access Journals (Sweden)

    Fonseca Joao A

    2012-08-01

    Full Text Available Abstract Background The Control of Allergic Rhinitis and Asthma Test (CARAT10 has been proposed as the first tool to implement the Allergic Rhinitis and its Impact on Asthma initiative guidelines in clinical practice. To serve this purpose, it must have adequate properties to assess the control of an individual over time. This study aimed to prospectively assess the test-retest reliability, responsiveness and longitudinal validity of CARAT10. Methods Adults with asthma and allergic rhinitis were enrolled at 4 outpatient clinics of Portuguese central hospitals. At each of the two visits, 4 to 6 weeks apart, patients filled out CARAT10 and additional questionnaires, followed by a medical evaluation blinded to the questionnaires’ answers. Results From the 62 patients included, 51 patients completely filled out CARAT10 at both visits. The test-retest reliability, computed as an intra-class correlation coefficient, was 0.82. Regarding responsiveness, a significant change (p = 0.002 of CARAT10 score in clinically unstable patients was observed (95%CI -5.08; -1.31 and the Guyatt’s responsiveness index was 1.54. As for the longitudinal validity assessment, the correlation coefficients of the changes of CARAT10 scores with those of ACQ5 and symptoms VAS ranged from 0.49 to 0.65, while with the physician assessment of control they ranged from 0.31 to 0.41. Conclusion CARAT10 has good test-retest reliability, responsiveness and longitudinal validity. It can be used to assess control of allergic rhinitis and asthma, both to compare groups in clinical studies and to evaluate individual patients in clinical practice.

  8. Current management of allergic rhinitis in children

    NARCIS (Netherlands)

    C. Georgalas; I. Terreehorst; W. Fokkens

    2010-01-01

    Over the last 20 years, there has been significant progress in our understanding of the pathophysiology of allergic rhinitis, including the discovery of new inflammatory mediators, the link between asthma and allergic rhinitis ('one airway-one disease' concept) and the introduction of novel therapeu

  9. Pharmacoeconomic study results of the access to drugs and treatment among patients with allergic rhinitis in Uzbekistan

    Directory of Open Access Journals (Sweden)

    Nizom Suyunov

    2011-03-01

    Full Text Available The paper discusses survey results made among 104 leading physicians of specialized offices with indication of forms and dose for drugs widely used for allergic rhinitis. The aim of the inquiry was carrying out VEN- analysis to define groups of drugs which efficacy should provide their more wide use in treatment of allergic rhinitis in near future.

  10. Treatment of allergic rhinitis is associated with improved attention performance in children: the Allergic Rhinitis Cohort Study for Kids (ARCO-Kids.

    Directory of Open Access Journals (Sweden)

    Dong-Kyu Kim

    Full Text Available BACKGROUND: It has been well known that pediatric allergic rhinitis was associated with poor performance at school due to attention deficit. However, there were no cohort studies for the effect of treatment of allergic rhinitis on attention performance in pediatric population. Thus, the aim of this study was to investigate whether attention performance was improved after treatment in children with allergic rhinitis. METHODS: In this ARCO-Kids (Allergic Rhinitis Cohort Study for Kids, consecutive pediatric patients with rhinitis symptoms underwent a skin prick test and computerized comprehensive attention test. According to the skin prick test results, the children were diagnosed as allergic rhinitis or non- allergic rhinitis. All of the patients were regularly followed up and treated with oral medication or intranasal corticosteroid sprays. The comprehensive attention tests consisted of sustained and divided attention tasks. Each of the tasks was assessed by the attention score which was calculated by the number of omission and commission errors. The comprehension attention test was repeated after 1 year. RESULTS: A total of 797 children with allergic rhinitis and 239 children with non-allergic rhinitis were included. Initially, the attention scores of omission and commission errors on divided attention task were significantly lower in children with allergic rhinitis than in children with non-allergic rhinitis. After 1 year of treatment, children with allergic rhinitis showed improvement in attention: commission error of sustained (95.6±17.0 vs 97.0±16.6 and divided attention task (99.1±15.8 vs 91.8±23.5. Meanwhile, there was no significant difference of attention scores in children with non-allergic rhinitis. CONCLUSIONS: Our study showed that management of allergic rhinitis might be associated with improvement of attention.

  11. Prevalence of Aeroallergens in Allergic Rhinitis in Shiraz

    Directory of Open Access Journals (Sweden)

    Sara Kashef

    2003-12-01

    Full Text Available Allergic rhinitis is an extremely common disease worldwide. Aeroallergens are very often involved in allergic rhinitis and their prevalence may vary in differ¬ent regions. The causative allergens of allergic rhinitis in our area are unknown.The purpose of this study was to determine the prevalence of skin reactivity to different aeroallergens in patients with allergic rhinitis in the city of Shiraz, Iran.A total of 212 patients who were referred to Motahari Allergy Clinic with chronic rhinitis were subjected to skin prick test (SPT with a series of common allergenic extracts including grasses, weeds, trees, house dust mites and moulds.One hundred and thirty two subjects (62.2% had positive SPT to at least one aeroallergen. Male to female ratio was 1.2 and mean age was 18.2 years. The prevalence rates for allergen groups were: pollens (92.4%, mites (22.7% and moulds (8.3%. Among 122 patients reactive to pollens, 92 (75.4% showed skin reactivity to weeds, 78 (63.9% to grasses and 68 (55.7% to trees. Polysensitization was common, with 75.7% of all sensitized patients being posi¬tive to more than one aeroallergen.Pollens are the main sensitizing allergens among patients with allergic rhinitis in Shiraz. This pattern of prevalence was expected based on herbal geography, climate and also found to be compatible with the results from studies carried out in places with the same habitat.

  12. Effects of intranasal TNFα on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Andersson Morgan

    2008-01-01

    Full Text Available Abstract Background TNFα may contribute to the pathophysiology of airway inflammation. For example, we have recently shown that nasal administration of TNFα produces late phase co-appearance of granulocyte and plasma exudation markers on the mucosal surface. The objective of the present study was to examine indices of granulocyte presence and activity in response to intranasal TNFα challenge. Methods Healthy subjects and patients with allergic rhinitis (examined out of season were subjected to nasal challenge with TNFα (10 μg in a sham-controlled and crossover design. Nasal lavages were carried out prior to and 24 hours post challenge. Nasal biopsies were obtained post challenge. Nasal lavage fluid levels of myeloperoxidase (MPO and eosinophil cationic protein (ECP were analyzed as indices of neutrophil and eosinophil activity. Moreover, IL-8 and α2-macroglobulin were analyzed as markers of pro-inflammatory cytokine production and plasma exudation. Nasal biopsy numbers of neutrophils and eosinophils were monitored. Results Nasal lavage fluid levels of MPO recorded 24 hours post TNFα challenge were increased in healthy subjects (p = 0.0081 and in patients with allergic rhinitis (p = 0.0081 (c.f. sham challenge. Similarly, α2-macroglobulin was increased in healthy subjects (p = 0.014 and in patients with allergic rhinitis (p = 0.0034. Lavage fluid levels of ECP and IL-8 were not affected by TNFα challenge. TNFα increased the numbers of subepithelial neutrophils (p = 0.0021, but not the numbers of eosinophils. Conclusion TNFα produces a nasal inflammatory response in humans that is characterised by late phase (i.e., 24 hours post challenge neutrophil activity and plasma exudation.

  13. Comparison of nasal responsiveness to histamine, methacholine and phentolamine in allergic rhinitis patients and controls

    NARCIS (Netherlands)

    R. Gerth van Wijk (Roy); P.H. Dieges

    1987-01-01

    textabstractIn a selected group of rhinitis patients with an IgE‐mediated allergy to house dust mites the nasal response to insufflation of histamine chloride, methacholine and phentolamine was demonstrated to be higher than in a control group. With the methods used histamine chloride was better at

  14. Clinical Research into Ke Min Yin for Treatment of Persistent Allergic Rhinitis in Patients with Qi Deficiency and Blood Stasis

    Institute of Scientific and Technical Information of China (English)

    刘巧平; 刘建华; 刘大新

    2003-01-01

    @@ Persistent allergic rhinitis (PAR) is one of the common diseases at ear-nose-throat department. From August 1998 to May 2001, we randomly selected 60 cases of PAR with qi deficiency and blood stasis for a clinical observation. 30 patients in the treatment group were treated with Ke Min Yin (克敏饮), a herbal medicine, to supplement qi, expel wind, nourish blood and promote blood circulation; and the other 30 cases in the control group were treated with cetrine. Through systematic observation and statistical processing, the clinical research is summarized and reported in the following.

  15. Patients with asthma and comorbid allergic rhinitis: is optimal quality of life achievable in real life?

    Directory of Open Access Journals (Sweden)

    Fulvio Braido

    Full Text Available OBJECTIVES: Asthma trials suggest that patients reaching total disease control have an optimal Health Related Quality of Life (HRQoL. Moreover, rhinitis is present in almost 80% of asthmatics and impacts asthma control and patient HRQoL. We explored whether optimal HRQoL was reachable in a real-life setting, and evaluated the disease and patient related patterns associated to optimal HRQoL achievement. METHODS AND FINDINGS: Asthma and rhinitis HRQoL, illness perception, mood profiles, rhinitis symptoms and asthma control were assessed by means of validated tools in patients classified according to GINA and ARIA guidelines. Optimal HRQoL, identified by a Rhinasthma Global Summary (GS score ≤20 (score ranging from 0 to 100, where 100 represents the worst possible HRQoL, was reached by 78/209 (37.32%. With the exception of age, no associations were found between clinical and demographic characteristics and optimal HRQoL achievement. Patients reaching an optimal HRQoL differed in disease perception and mood compared to those not reaching an optimal HRQoL. Asthma control was significantly associated with optimal HRQoL (χ(2 = 49.599; p<0.001 and well-controlled and totally controlled patients significantly differed in achieving optimal HRQoL (χ(2 = 7.617; p<0.006. CONCLUSION: Approximately one third of the patients in our survey were found to have an optimal HRQoL. While unsatisfactory disease control was the primary reason why the remainder failed to attain optimal HRQoL, it is clear that illness perception and mood also played parts. Therefore, therapeutic plans should be directed not only toward achieving the best possible clinical control of asthma and comorbid rhinitis, but also to incorporating individualized elements according to patient-related characteristics.

  16. Sleep disturbances in allergic rhinitis: disease and/or the drug?

    OpenAIRE

    Anant D. Patil

    2013-01-01

    Allergic rhinitis is a common chronic disease in adults as well as children. Allergic rhinitis has negative impact on sleep and quality of life of the patient. Antihistamines are widely used in the management of allergic rhinitis. First generation antihistamines cause sedation and drowsiness. Second generation antihistamines cause minimal or no sedation. There is difference in propensity to cause sedation amongst second generation antihistamines. As sleep is important for physical as well as ...

  17. Sleep disturbances in allergic rhinitis: disease and/or the drug?

    Directory of Open Access Journals (Sweden)

    Anant D. Patil

    2013-12-01

    Full Text Available Allergic rhinitis is a common chronic disease in adults as well as children. Allergic rhinitis has negative impact on sleep and quality of life of the patient. Antihistamines are widely used in the management of allergic rhinitis. First generation antihistamines cause sedation and drowsiness. Second generation antihistamines cause minimal or no sedation. There is difference in propensity to cause sedation amongst second generation antihistamines. As sleep is important for physical as well as mental health, present article reviews impact of allergic rhinitis and antihistamines on sleep. [Int J Basic Clin Pharmacol 2013; 2(6.000: 668-670

  18. Role of sphingosine 1-phosphate receptor expression in eosinophils of patients with allergic rhinitis, and effect of topical nasal steroid treatment on this receptor expression.

    LENUS (Irish Health Repository)

    Mackle, T

    2008-12-01

    Recent research has indicated that sphingosine 1-phosphate plays a role in allergy. This study examined the effect of allergen challenge on the expression of sphingosine 1-phosphate receptors on the eosinophils of allergic rhinitis patients, and the effect of steroid treatment on this expression.

  19. [Therapy of allergic rhinitis: the preferences of specialists].

    Science.gov (United States)

    Danilova, K V; Razdorskaia, I M

    2014-01-01

    The objective of the present work was to study the stereotypes of addressing such a serious medical problem as the treatment of allergic rhinitis by practicing physicians and the development of criteria for the priority choice of pharmaceutical products to be prescribed to the patients presenting with this pathology. This pharmacoepidemiological investigation was designed to elucidate the preferences shown by specialists dealing with this disease. The special questionnaire was developed to collect and analyse the opinions of otorhinolaryngologists and allergologists. The study has demonstrated that both therapy of allergic rhinitis and preferences of specialists conform with the respective international standards. However, the study revealed the lack of the adequate communicative and informational interactions between two basic components of the healthcare system, viz. doctors and pharmacists. The authors emphasize the necessity to optimize professional approaches to the management of allergic rhinitis.

  20. Advances in pharmacotherapy for the treatment of allergic rhinitis

    DEFF Research Database (Denmark)

    Bousquet, Jean; Bachert, Claus; Bernstein, Jonathan;

    2015-01-01

    INTRODUCTION: Effective pharmacologic treatment exists for most patients suffering from allergic rhinitis (AR). However, both in clinical trials and in real-life studies, many patients are dissatisfied with treatment. Physicians often use multiple therapies, in an attempt to improve symptom contr...

  1. Use of intranasal corticosteroids in the management of congestion and sleep disturbance in pediatric patients with allergic rhinitis.

    Science.gov (United States)

    Lanier, Bob Q

    2008-06-01

    Allergic rhinitis affects a large number of children and exerts a considerable socioeconomic impact. It is underdiagnosed and inadequately treated, which predisposes children to potentially serious comorbidities. Allergic rhinitis symptoms may create nighttime breathing problems and sleep disturbances and have a negative effect on a child's ability to learn in the classroom. Although antihistamines have shown efficacy in relieving many symptoms, they have little effect on nasal congestion. This article summarizes the advantages of intranasal corticosteroids, including their effectiveness against congestion and excellent safety profile. Intranasal corticosteroids with minimal systemic bioavailability provide topical drug delivery that minimizes the potential for systemic side-effects.

  2. Treatment Evaluation with Mometasone Furoate, Alone or in Combination with Desloratadine/ Montelukast in Moderate Severe Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Florincescu-Gheorghe Nona-Aura

    2014-06-01

    Full Text Available Introduction: Allergic rhinitis is one of the most common allergic diseases, characterized by the inflammation of the nasal mucosa. Eosinophils play a predominant pro-inflammatory role in allergic inflammation. This study assesses the effect of mometasone furoate alone or in combination with desloratadine/montelukast in patients with moderate-severe allergic rhinitis.

  3. From IgE to clinical trials of allergic rhinitis.

    Science.gov (United States)

    Ciprandi, Giorgio; Marseglia, Gian Luigi; Castagnoli, Riccardo; Valsecchi, Chiara; Tagliacarne, Carlotta; Caimmi, Silvia; Licari, Amelia

    2015-01-01

    The current scientific research is continuously aiming at identifying new therapeutic targets with the purpose of modifying the immune response to allergens. The evolution in immunological methods has led to the identification of immunoglobulin E (IgE) as both a diagnostic biomarker and potential therapeutic target in allergic diseases, such as allergic rhinitis. Allergen immunotherapy has been used for more than 100 years to treat allergic diseases and it is today considered the only disease-modifying treatment capable of inducing a long-lasting immunological and clinical tolerance toward the causal allergen. During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. Moreover, there has been considerable progress in allergen extract modifications and additions to standard extracts. The recognition that IgE plays a pivotal role in basic regulatory mechanisms of allergic inflammation has recently stimulated research into the therapeutic potential of directly targeting this antibody. Omalizumab, the most advanced humanized anti-IgE monoclonal antibody, is currently approved for the treatment of uncontrolled allergic asthma and chronic spontaneous urticaria. Interesting results also arise from studies in which omalizumab was administered in patients with allergic rhinitis. The aim of this review is to provide an update on current findings on immunological and clinical effects of allergen immunotherapy and anti-IgE therapy, which have been shown to have synergistic modes of action for the treatment of allergic rhinitis.

  4. Effect of pre-seasonal seasonal treatment with budesonide topical nasal powder in patients with seasonal allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Maria C Morelli

    1996-01-01

    Full Text Available The efficacy and safety of budesonide nasal powder (Rhinocort Turbuhaler® in seasonal allergic rhinitis when given only at the onset of symptoms during the pollen season or when also given before the pollen season, were compared. The study was carried out in 364 patients from 14 centres in Italy as a randomized, double-blind, parallel-group, placebo- controlled comparison of five alternative treatment regimens given for 4 weeks during the pre-pollen and early pollen season (PPS and for 6 weeks during the pollen season (PS. It was concluded that either 200μg or 400μg of budesonide given once daily PPS provides significant control of symptoms experienced during PPS. The 400μg dose, however, also provides additional prophylactic protection against symptoms during early PS. When the pollen season is established, the dose of budesonide may be reduced to 200μg.

  5. Allergic rhinitis management pocket reference 2008.

    NARCIS (Netherlands)

    Bousquet, J.; Reid, J.; Weel, C. van; Cagnani, C. Baena; Canonica, G.W.; Demoly, P.; Denburg, J.; Fokkens, W.J.; Grouse, L.; Mullol, K.; Ohta, K.; Schermer, T.; Valovirta, E.; Zhong, N.; Zuberbier, T.

    2008-01-01

    Allergic rhinitis is a major chronic respiratory disease because of its prevalence, impacts on quality of life and work/school performance, economic burden, and links with asthma. Family doctors (also known as 'primary care physicians' or 'general practitioners') play a major role in the management

  6. Steroids vs immunotherapy for allergic rhinitis

    DEFF Research Database (Denmark)

    Aasbjerg, Kristian; Backer, Vibeke

    2014-01-01

    Treatment for seasonal allergic rhinitis induced by airborne allergens can be divided into two major groups: symptom-dampening drugs, such as antihistamines and corticosteroids, and disease-modifying drugs in the form of immunotherapy. It has been speculated that depot-injection corticosteroids g...

  7. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis) : the new generation guideline implementation

    NARCIS (Netherlands)

    Bousquet, J.; Schunemann, H. J.; Fonseca, J.; Samolinski, B.; Bachert, C.; Canonica, G. W.; Casale, T.; Cruz, A. A.; Demoly, P.; Hellings, P.; Valiulis, A.; Wickman, M.; Zuberbier, T.; Bosnic-Anticevitch, S.; Bedbrook, A.; Bergmann, K. C.; Caimmi, D.; Dahl, R.; Fokkens, W. J.; Grisle, I.; Lodrup Carlsen, K.; Mullol, J.; Muraro, A.; Palkonen, S.; Papadopoulos, N.; Passalacqua, G.; Ryan, D.; Valovirta, E.; Yorgancioglu, A.; Aberer, W.; Agache, I.; Adachi, M.; Akdis, C. A.; Akdis, M.; Annesi-Maesano, I.; Ansotegui, I. J.; Anto, J. M.; Arnavielhe, S.; Arshad, H.; Baiardini, I.; Baigenzhin, A. K.; Barbara, C.; Bateman, E. D.; Beghe, B.; Bel, E. H.; Ben Kheder, A.; Bennoor, K. S.; Benson, M.; Bewick, M.; Bieber, T.; Bindslev-Jensen, C.; Bjermer, L.; Blain, H.; Boner, A. L.; Boulet, L. P.; Bonini, M.; Bonini, S.; Bosse, I.; Bourret, R.; Bousquet, P. J.; Braido, F.; Briggs, A. H.; Brightling, C. E.; Brozek, J.; Buhl, R.; Burney, P. G.; Bush, A.; Caballero-Fonseca, F.; Calderon, M. A.; Camargos, P. A. M.; Camuzat, T.; Carlsen, K. H.; Carr, W.; Sarabia, A. M. Cepeda; Chavannes, N. H.; Chatzi, L.; Chen, Y. Z.; Chiron, R.; Chkhartishvili, E.; Chuchalin, A. G.; Ciprandi, G.; Cirule, I.; Correia de Sousa, J.; Cox, L.; Crooks, G.; Costa, D. J.; Custovic, A.; Dahlen, S. E.; Darsow, U.; De Carlo, G.; De Blay, F.; Dedeu, T.; Deleanu, D.; Denburg, J. A.; Devillier, P.; Didier, A.; Dinh-Xuan, A. T.; Dokic, D.; Douagui, H.; Dray, G.; Dubakiene, R.; Durham, S. R.; Dykewicz, M. S.; El-Gamal, Y.; Emuzyte, R.; Wagner, A. Fink; Fletcher, M.; Fiocchi, A.; Forastiere, F.; Gamkrelidze, A.; Gemicioglu, B.; Gereda, J. E.; Gonzalez Diaz, S.; Gotua, M.; Grouse, L.; Guzman, M. A.; Haahtela, T.; Hellquist-Dahl, B.; Heinrich, J.; Horak, F.; Hourihane, J. O. B.; Howarth, P.; Humbert, M.; Hyland, M. E.; Ivancevich, J. C.; Jares, E. J.; Johnston, S. L.; Joos, G.; Jonquet, O.; Jung, K. S.; Just, J.; Kaidashev, I.; Kalayci, O.; Kalyoncu, A. F.; Keil, T.; Keith, P. K.; Khaltaev, N.; Klimek, L.; N'Goran, B. Koffi; Kolek, V.; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kuna, P.; Kvedariene, V.; Lambrecht, B.; Lau, S.; Larenas-Linnemann, D.; Laune, D.; Le, L. T. T.; Lieberman, P.; Lipworth, B.; Li, J.; Louis, R.; Magard, Y.; Magnan, A.; Mahboub, B.; Majer, I.; Makela, M. J.; Manning, P.; De Manuel Keenoy, E.; Marshall, G. D.; Masjedi, M. R.; Maurer, M.; Mavale-Manuel, S.; Melen, E.; Melo-Gomes, E.; Meltzer, E. O.; Merk, H.; Miculinic, N.; Mihaltan, F.; Milenkovic, B.; Mohammad, Y.; Molimard, M.; Momas, I.; Montilla-Santana, A.; Morais-Almeida, M.; Moesges, R.; Namazova-Baranova, L.; Naclerio, R.; Neou, A.; Neffen, H.; Nekam, K.; Niggemann, B.; Nyembue, T. D.; O'Hehir, R. E.; Ohta, K.; Okamoto, Y.; Okubo, K.; Ouedraogo, S.; Paggiaro, P.; Pali-Schoell, I.; Palmer, S.; Panzner, P.; Papi, A.; Park, H. S.; Pavord, I.; Pawankar, R.; Pfaar, O.; Picard, R.; Pigearias, B.; Pin, I.; Plavec, D.; Pohl, W.; Popov, T. A.; Portejoie, F.; Postma, D.; Potter, P.; Price, D.; Rabe, K. F.; Raciborski, F.; Pontal, F. Radier; Repka-Ramirez, S.; Robalo-Cordeiro, C.; Rolland, C.; Rosado-Pinto, J.; Reitamo, S.; Rodenas, F.; Roman Rodriguez, M.; Romano, A.; Rosario, N.; Rosenwasser, L.; Rottem, M.; Sanchez-Borges, M.; Scadding, G. K.; Serrano, E.; Schmid-Grendelmeier, P.; Sheikh, A.; Simons, F. E. R.; Sisul, J. C.; Skrindo, I.; Smit, H. A.; Sole, D.; Sooronbaev, T.; Spranger, O.; Stelmach, R.; Strandberg, T.; Sunyer, J.; Thijs, C.; Todo-Bom, A.; Triggiani, M.; Valenta, R.; Valero, A. L.; van Hage, M.; Vandenplas, O.; Vezzani, G.; Vichyanond, P.; Viegi, G.; Wagenmann, M.; Walker, S.; Wang, D. Y.; Wahn, U.; Williams, D. M.; Wright, J.; Yawn, B. P.; Yiallouros, P. K.; Yusuf, O. M.; Zar, H. J.; Zernotti, M. E.; Zhang, L.; Zhong, N.; Zidarn, M.; Mercier, J.

    2015-01-01

    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient e

  8. Allergic Rhinitis and its Impact on Asthma (ARIA)

    DEFF Research Database (Denmark)

    Bousquet, J; Schünemann, H J; Samolinski, B;

    2012-01-01

    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has rec...

  9. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis

    DEFF Research Database (Denmark)

    Chawes, Bo Lk

    2011-01-01

    Allergic- and non-allergic rhinitis are very common diseases in childhood in industrialized countries. Although these conditions are widely trivialized by both parents and physicians they induce a major impact on quality of life for the affected children and a substantial drainage of health care...... symptom in both allergic- and non-allergic rhinitis, and eosinophilic inflammation is a hallmark of the allergic diseases. In paper I, we studied nasal eosinophilia and nasal airway patency assessed by acoustic rhinometry in children with allergic rhinitis, non-allergic rhinitis and healthy controls...... nasal eosinophilia albeit less than children with allergic rhinitis. These findings suggest different pathology in allergic- and non-allergic rhinitis which may have important clinical implications for early pharmacological treatment of rhinitis in young children. In paper II, we utilized the nasal...

  10. The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression.

    Directory of Open Access Journals (Sweden)

    Ariane H Wagener

    Full Text Available BACKGROUND: The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. OBJECTIVE: Defining gene expression profiles of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. METHODS: This cross-sectional study included 18 subjects (6 allergic asthma and allergic rhinitis; 6 allergic rhinitis; 6 healthy controls. The estimated false discovery rate comparing 6 subjects per group was approximately 5%. RNA was extracted from isolated and cultured epithelial cells from bronchial brushings and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array. Data were analysed using R and Bioconductor Limma package. For gene ontology GeneSpring GX12 was used. RESULTS: The study was successfully completed by 17 subjects (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls. Using correction for multiple testing, 1988 genes were differentially expressed between healthy lower and upper airway epithelium, whereas in allergic rhinitis with or without asthma this was only 40 and 301 genes, respectively. Genes influenced by allergic rhinitis with or without asthma were linked to lung development, remodeling, regulation of peptidases and normal epithelial barrier functions. CONCLUSIONS: Differences in epithelial gene expression between the upper and lower airway epithelium, as observed in healthy subjects, largely disappear in patients with allergic rhinitis with or without asthma, whilst new differences emerge. The present data identify several pathways and genes that might be

  11. Role of Predatory Mites in Persistent Nonoccupational Allergic Rhinitis

    Science.gov (United States)

    Poza Guedes, Paloma; Sánchez Machín, Inmaculada; Matheu, Víctor; Iraola, Víctor

    2016-01-01

    Mites can sensitize and induce atopic disease in predisposed individuals and are an important deteriorating factor in patients with allergic rhinitis, asthma, and atopic dermatitis. Although Pyroglyphidae mites have been extensively studied, very scarce reports are available on Cheyletidae spp. especially regarding human respiratory pathology. The main objective of the present study is to investigate the clinical role of this predator mite (Cheyletus eruditus) as a respiratory antigen in a selected sensitized human population. Fifty-two adult patients were recruited from the outpatient allergy clinic to assess their eligibility for the study. The thirty-seven subjects with persistent allergic rhinitis (PAR) who fulfilled the ARIA criteria had a positive IgE response confirmed by skin prick test (SPT) to C. eruditus. Only those individuals (37/47) with a positive SPT to C. eruditus showed a positive nasal provocation test (NPT), while 10 patients with nonallergic mild-to-moderate persistent rhinitis, control group, had a negative NPT with C. eruditus. The present paper describes a new role for the predator mite Cheyletus eruditus as a respiratory allergen in a selected subset of patients in a subtropical environment afflicted with persistent nonoccupational allergic rhinitis. PMID:27445552

  12. Role of Predatory Mites in Persistent Nonoccupational Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Paloma Poza Guedes

    2016-01-01

    Full Text Available Mites can sensitize and induce atopic disease in predisposed individuals and are an important deteriorating factor in patients with allergic rhinitis, asthma, and atopic dermatitis. Although Pyroglyphidae mites have been extensively studied, very scarce reports are available on Cheyletidae spp. especially regarding human respiratory pathology. The main objective of the present study is to investigate the clinical role of this predator mite (Cheyletus eruditus as a respiratory antigen in a selected sensitized human population. Fifty-two adult patients were recruited from the outpatient allergy clinic to assess their eligibility for the study. The thirty-seven subjects with persistent allergic rhinitis (PAR who fulfilled the ARIA criteria had a positive IgE response confirmed by skin prick test (SPT to C. eruditus. Only those individuals (37/47 with a positive SPT to C. eruditus showed a positive nasal provocation test (NPT, while 10 patients with nonallergic mild-to-moderate persistent rhinitis, control group, had a negative NPT with C. eruditus. The present paper describes a new role for the predator mite Cheyletus eruditus as a respiratory allergen in a selected subset of patients in a subtropical environment afflicted with persistent nonoccupational allergic rhinitis.

  13. Justification of advisability of using physical factors in the treatment of patients with allergic rhinitis and associated bronchial asthma

    Directory of Open Access Journals (Sweden)

    T. N. Zaripova

    2012-01-01

    Full Text Available The efficiency of treatment of patients with allergic rhinitis and associated bronchial asthma by physical factors and advisability of two-stage treatment are justified. Sixty six patients were observed. The conclusion on the efficiency of treatment was based on the data about the dynamics clinical state of the primary and associated diseases, intensity of inflammation activity in respiratory tract (rhinocytograms, biochemical indices of nasal lavages, level of nitrogen oxide in expired air were studied, patency of airways (manometry, spirography. We compared two versions of treatment: two- and one-stage. Patients of the first group (30 patients received elimination therapy for 3 to 5 days with the following peaty mud application, current of supersonic frequency, massage, inhalations, physical therapy. Patients of the second group (36 patients did not receive elimination therapy. We have found a decrease in intensity of clinical implications of the primary and associated diseases, decrease in inflammation activity, better nasal and bronchial носовой patency, improvement of the mucociliary function in patients of the first group. In the second group, the recovery of the surface epithelium and nasal patency was not observed against the background of improvement of the clinical state.

  14. Clinical Profile, Co-Morbidities and Health Related Quality of Life in Pediatric Patients with Allergic Rhinitis and Asthma

    Directory of Open Access Journals (Sweden)

    Keya R. Lahiri, Milind S. Tullu* and Rachna Kalra

    2010-10-01

    Full Text Available Background: Co-existence of allergic rhinitis (AR and bronchial asthma (BA is well known. We planned to study the clinical profile of patients with AR & BA, the associated co-morbidities and the effect of AR &/ or BA on health related quality of life (HRQOL in Pediatric patients. Methods: Patients attending the Pediatric out-patients department and Pediatric Chest Clinic of tertiary care center were enrolled. The sample size included 100 subjects with BA & AR (Group 1 with control groups of 60 asthmatic children (Group 2 & 40 children suffering from AR (Group 3. The patients were subjected to a questionnaire & a through physical examination and the details were recorded in a pre-designed proforma. General medical, environmental, occupational, personal & family history was procured along with examination of respiratory system. The standard heath related quality of life (HRQOL parameters were studied. Findings: The study was conducted over a period of 13 months (February 2004 to March 2005. 200 patients between ages of 3 to 15 years (mean 7.95 years were enrolled (100 patients with BA and AR- group 1, 60 patients with asthma alone- group 2 and 40 patients with AR alone- group 3. Dust, smoke, outdoor dust, holi festival, winter season, exercise, and smoking by father were important exacerbating factors in all the three groups. Additionally, diwali festival and family history of asthma were important in Group 2 (BA; while pollen, weeds, diwali festival and family history of allergic rhinitis were important causes of exacerbation in group 3 (AR. Cough was commonly seen in all three groups. Wheezing, sneezing, itching throat, rhinorrhea, watering, altered taste, and nasal block was common in patients in group 1 while wheezing was important symptom in patients in group 2 (BA. Sneezing, itching throat, rhinorrhea, watering, altered taste, and nasal block were common symptoms in patients in group 3 (AR. Conjunctivitis, pharyngitis, and post-nasal drip

  15. Role of leukotriene antagonists and antihistamines in the treatment of allergic rhinitis.

    Science.gov (United States)

    Cobanoğlu, Bengü; Toskala, Elina; Ural, Ahmet; Cingi, Cemal

    2013-04-01

    Allergic rhinitis is the most common atopic disorder seen in ENT clinics. It is diagnosed by history, physical exam and objective testing. Patient education, environmental control measures, pharmacotherapy, and allergen-specific immunotherapy are the cornerstones of allergic rhinitis treatment and can significantly reduce the burden of disease. Current treatment guidelines include antihistamines, intranasal corticosteroids, oral and intranasal decongestants, intranasal anticholinergics, intranasal cromolyn, and leukotriene receptor antagonists. In the mechanism of allergic rhinitis, histamine is responsible for major allergic rhinitis symptoms such as rhinorrhea, nasal itching and sneezing. Its effect on nasal congestion is less evident. In contrast, leukotrienes result in increase in nasal airway resistance and vascular permeability. Antihistamines and leukotriene receptor antagonists are commonly used in the treatment of allergic rhinitis. The published literature about combined antihistamines and leukotriene antagonists in mono- or combination therapy is reviewed and presented.

  16. Association Between Neonatal Urinary Tract Infection and Risk of Childhood Allergic Rhinitis.

    Science.gov (United States)

    Lin, Chien-Heng; Lin, Wei-Ching; Wang, Yu-Chiao; Lin, I-Ching; Lin, I Ching; Kao, Chia-Hung

    2015-09-01

    The current population-based study investigated the onset of neonatal urinary tract infection (UTI) and the associated risks of allergic rhinitis. From 2000 to 2005, 3285 children with neonatal UTI and 13,128 randomly selected controls were enrolled from the National Health Insurance Research Database in Taiwan and frequency matched by gender, urbanization of residential area, parental occupation, and baseline year. We compared the risk of allergic rhinitis between the non-UTI and UTI cohorts by performing multivariable Cox regression analysis. We observed a significant relationship between UTI and allergic rhinitis. This study examined 16,413 patients, among whom 3285 had UTI and 13,128 did not have UTI. The overall incidence rate ratio of allergic rhinitis was 1.41-fold higher in the UTI cohort than in the non-UTI cohort (100.2 vs 70.93 per 1000 person-y). After potential risk factors were adjusted for, the adjusted hazard ratio of allergic rhinitis was 1.32 (95% confidence interval = 1.23-1.41). Regardless of gender, the UTI cohort had a higher risk of allergic rhinitis than that of the non-UTI cohort. The patients with UTI in different follow-up durations were equally susceptible to developing allergic rhinitis compared with those without UTI, especially in follow-up durations shorter than 5 years. Patients with UTI and particular comorbidities such as infections and neonatal jaundice had a significantly increased risk of allergic rhinitis. UTI in newborns is significantly associated with the development of allergic rhinitis in childhood and might be a risk factor for subsequent childhood allergic rhinitis.

  17. Benzaldehyde suppresses murine allergic asthma and rhinitis.

    Science.gov (United States)

    Jang, Tae Young; Park, Chang-Shin; Kim, Kyu-Sung; Heo, Min-Jeong; Kim, Young Hyo

    2014-10-01

    To evaluate the antiallergic effects of oral benzaldehyde in a murine model of allergic asthma and rhinitis, we divided 20 female BALB/c mice aged 8-10 weeks into nonallergic (intraperitoneally sensitized and intranasally challenged to normal saline), allergic (intraperitoneally sensitized and intranasally challenged to ovalbumin), and 200- and 400-mg/kg benzaldehyde (allergic but treated) groups. The number of nose-scratching events in 10 min, levels of total and ovalbumin-specific IgE in serum, differential counts of inflammatory cells in bronchoalveolar lavage (BAL) fluid, titers of Th2 cytokines (IL-4, IL-5, IL-13) in BAL fluid, histopathologic findings of lung and nasal tissues, and expressions of proteins involved in apoptosis (Bcl-2, Bax, caspase-3), inflammation (COX-2), antioxidation (extracellular SOD, HO-1), and hypoxia (HIF-1α, VEGF) in lung tissue were evaluated. The treated mice had significantly fewer nose-scratching events, less inflammatory cell infiltration in lung and nasal tissues, and lower HIF-1α and VEGF expressions in lung tissue than the allergic group. The number of eosinophils and neutrophils and Th2 cytokine titers in BAL fluid significantly decreased after the treatment (Pbenzaldehyde exerts antiallergic effects in murine allergic asthma and rhinitis, possibly through inhibition of HIF-1α and VEGF.

  18. Olfaction in allergic rhinitis: A systematic review.

    Science.gov (United States)

    Stuck, Boris A; Hummel, Thomas

    2015-12-01

    Olfactory dysfunction is a key symptom in patients with allergic rhinitis (AR). Despite the implications for quality of life, relatively few articles have tested olfactory function in their investigations. The current systematic review aimed to investigate the following 2 questions: (1) What does AR do to human olfaction? (2) How effective is the treatment of AR in restoring the sense of smell? A comprehensive literature search was performed, and human studies of any design were included. A total of 420 articles were identified, and 36 articles were considered relevant. Data indicate that the frequency of olfactory dysfunction increases with the duration of the disorder, and most studies report a frequency in the range of 20% to 40%. Although olfactory dysfunction does not appear to be very severe in patients with AR, its presence seems to increase with the severity of the disease. There is very limited evidence that antihistamines improve olfactory function. In addition, there is limited evidence that topical steroids improve the sense of smell, especially in patients with seasonal AR. This is also the case for specific immunotherapy. However, many questions remain unanswered because randomized controlled trials are infrequent and only a few studies rely on quantitative measurement of olfactory function.

  19. Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study

    OpenAIRE

    Kimihiro Okubo; Minoru Gotoh; Mikiya Asako; Yasuyuki Nomura; Michinori Togawa; Akihiro Saito; Takayuki Honda; Yoshihiro Ohashi

    2017-01-01

    Background: Bilastine, a novel non-sedating second-generation H1 antihistamine, has been approved in most European countries since 2010. This study aimed to evaluate the superiority of bilastine over placebo in Japanese patients with perennial allergic rhinitis (PAR). Methods: This randomized, double-blind, placebo-controlled, parallel-group, phase III study (trial registration number JapicCTI-142600) evaluated the effect of a 2-week treatment period with bilastine (20 mg once daily), fexo...

  20. Children with allergic and nonallergic rhinitis have a similar risk of asthma

    DEFF Research Database (Denmark)

    Chawes, Bo Lund Krogsgaard; Bønnelykke, Klaus; Kreiner-Møller, Eskil;

    2010-01-01

    Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma.......Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma....

  1. 非变应性鼻炎与变应性鼻炎患者患病相关因素比较%Comparison of risk factors between patients with non-allergic rhinitis and allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    朱鲁平; 王菲; 孙小青; 陈若希; 陆美萍; 殷敏; 程雷

    2010-01-01

    Objective To investigate and describe the differences in age, sex, seasonality distribution, and related environmental factors between patients with non-allergic rhinitis (NAR) and allergic rhinitis (AR). Methods One hundred and eleven patients with NAR and 112 patients with AR were enrolled in this study. All patients were first diagnosed in outpatient department between January and August 2010. Questionnaires were distributed to all participants to record the general information, medical history, and the factors relevant to symptom onset. Statistical analysis was performed using a SPSS13.0 software. Results The proportion of patients with NAR increased with age, compared to patients with AR.The peak age was 21 -30 years old in patients with NAR, whereas 11 -20 years old in patients with AR. In adults more than 18 years old, the average age (years, -x±s) of patients with NAR (38.6 ± 14. 5) was significantly higher than those with AR (32. 8 ± 13.0; t =2. 58, P =0. 024). NAR was more likely to be males before 30 years old, while after 30 years old, it likely to be female predominance. The same case occurred in AR subjects but in their 20 years old. NAR was symptomatically worse in winter (χ2 = 27. 57,P = 0. 000), whereas AR worse in spring (χ2 = 13. 75, P = 0. 003). The cases of NAR were significantly more than those of AR during the winter season (x2 = 12. 34, P = 0. 000). Among the disease-related environmental factors, living or working place near the traffic artery had 1.94-fold increased risk for development of NAR compared with AR; however, living or working in ground floor or sunshine time less than 2 h per day had 1.77- or 1.91-fold increased risk for development of NAR compared with NAR.Subjects with personal or family history of allergic disease had 2. 14 to 4. 06-fold increased risk for development of AR compared with NAR. The self-reported predisposing factors in NAR patients were mainly including temperature shift (56. 3%), common cold (52. 8

  2. Subcutaneous Immunotherapy Improves the Symptomatology of Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Lourenço, Edmir Américo

    2015-10-01

    Full Text Available Introduction The relevance of allergic rhinitis is unquestionable. This condition affects people's quality of life and its incidence has increased over the last years. Objective Thus, this study aims to analyze the effectiveness of subcutaneous injectable immunotherapy in cases of nasal itching, sneeze, rhinorrhea and nasal congestion in allergic rhinitis patients. Methods In the present study, the same researcher analyzed the records of 281 patients. Furthermore, the researchers identified allergens through puncture cutaneous tests using standardized extracts containing acari, fungi, pet hair, flower pollen, and feathers. Then, the patients underwent treatment with subcutaneous specific immunotherapy, using four vaccine vials for desensitization, associated with environmental hygiene. The authors analyzed conditions of nasal itching, sneeze, rhinorrhea, and nasal congestion throughout the treatment, and assigned them with a score ranging from zero (0, meaning absence of these symptoms to three (3, for severe cases. The symptoms were statistically compared in the beginning, during, and after treatment. Results In this study, authors analyzed the cases distribution according to age and the evolution of symptomatology according to the scores, comparing all phases of treatment. The average score for the entire population studied was 2.08 before treatment and 0.44 at the end. These results represent an overall improvement of ∼79% in symptomatology of allergic rhinitis in the studied population. Conclusion The subcutaneous immunotherapy as treatment of allergic rhinitis led to a reduction in all symptoms studied, improving the quality of life of patients, proving itself as an important therapeutic tool for these pathological conditions.

  3. Elevated levels of manna-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associated with a novel intronic polymorphism in MBL

    DEFF Research Database (Denmark)

    Kaur, S.; Gupta, G.K.; Shah, A.;

    2006-01-01

    Mannan-binding lectin (MBL), an important component of innate immunity, binds to a range of foreign antigens and initiates the lectin complement pathway. Earlier studies have reported high plasma MBL levels in allergic patients in comparison to healthy controls. In view of varied plasma MBL levels...... being determined by genetic polymorphisms in its collagen region, we investigated the association of single nucleotide polymorphisms (SNPs) in the collagen region of human MBL with respiratory allergic diseases. The study groups comprised patients of bronchial asthma with allergic rhinitis (n = 49......) and allergic bronchopulmonary aspergillosis (APBA) (n = 11) and unrelated age-matched healthy controls of Indian origin (n = 84). A novel intronic SNP, G1011A of MBL, showed a significant association with both the patient groups in comparison to the controls (P

  4. Expression of Pendrin Periostin in Allergic Rhinitis Chronic Rhinosinusitis

    Directory of Open Access Journals (Sweden)

    Akihiro Ishida

    2012-01-01

    Conclusions: : Production of pendrin and periostin is upregulated in allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin-induced asthma. These findings suggest that pendrin can induce mucus production and that periostin can induce tissue fibrosis and remodeling in the nasal mucosa. Therefore, these mediators may be therapeutic target candidates for allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin- induced asthma.

  5. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis

    DEFF Research Database (Denmark)

    Chawes, Bo Lk

    2011-01-01

    Allergic- and non-allergic rhinitis are very common diseases in childhood in industrialized countries. Although these conditions are widely trivialized by both parents and physicians they induce a major impact on quality of life for the affected children and a substantial drainage of health care...... symptom in both allergic- and non-allergic rhinitis, and eosinophilic inflammation is a hallmark of the allergic diseases. In paper I, we studied nasal eosinophilia and nasal airway patency assessed by acoustic rhinometry in children with allergic rhinitis, non-allergic rhinitis and healthy controls...... or asthma should be considered inflamed in the entire respiratory tract. In paper III, we aimed to describe asthma and intermediary asthma end-points associated with allergic- and non-allergic rhinitis in preschool-aged children. At age 7 years, we evaluated prevalence of asthma, eczema, food sensitization...

  6. Extranasal symptoms of allergic rhinitis are difficult to treat and affect quality of life

    Directory of Open Access Journals (Sweden)

    Veeravich Jaruvongvanich

    2016-04-01

    Conclusions: Extranasal symptom scores correlated well with physical health and mental health in allergic rhinitis patients. Assessment of extranasal symptoms should be included to evaluate disease severity and assess therapeutic outcomes. Clinical trial NCT02000648, http://www.clinicaltrials.gov.

  7. The Current Management at Diagnosis and Treatment of Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Ozgur Tarkan

    2009-06-01

    Full Text Available Allergic rhinitis is a common disease with a remarkable social impact. The semptoms of allerjic rhinitis include itching, nasal discharge and sneezing. Similar to lethargy, fatigue, somnolence, decreased cognition, difficulty in concentration and decreased sleep and appetite is commonly seen besides physical symptoms. The treatment of allergic rhinitis consists of allergen avoidance, pharmacotherapy and immunotherapy. [Archives Medical Review Journal 2009; 18(3.000: 156-170

  8. Association between allergic rhinitis and migraine

    Directory of Open Access Journals (Sweden)

    Alia Saberi

    2012-01-01

    Full Text Available Background: Migraine and allergic rhinitis (AR are two common causes of headache and facial pain that inflammatory mediators with vasoactive function play important roles in both of them. The aim of this research was to determine the prevalence of migraine in AR patients. Materials and Methods: In a cross-sectional comparative study performed from June to December 2010 in patients with AR sign and symptoms referred to ear, nose, throat (ENT clinic of a university hospital in Iran-Rasht, 46 patients with positive skin prick test were compared with 60 subject without AR signs and symptoms and with negative skin test. In both the groups, history of migraine according to IHS (International Headache Society criteria were investigated. Analysis of data was performed by chi-sqaure and Fisher exact test by using SPSS16. Odds ratio were estimated for determining the chance of migraine in AR. Results: In case group (14 male, 37 female; mean age: 31.17 ± 8.31 years and control group (23 male, 32 female; mean age: 37.58 ± 12.63 years, the prevalence of migraine was 37% and 5%, respectively. The differences in prevalence of migraine and migraine without aura between cases and controls were significant (P = 0.001. The chance of migraine in AR was 8.227 folds (95% CI: 2.38-28.42. In subjects older than 40 years old, the difference of prevalence of migraine was significant, contrary to subjects younger than 30 years old and between 30 and 39 years old. Conclusions: There is a correlation between migraine especially without aura and AR and this correlation is more powerful with increasing age.

  9. Number of siblings and allergic rhinitis in children

    Directory of Open Access Journals (Sweden)

    Soewira Sastra

    2016-05-01

    Full Text Available Background Allergic rhinitis is one of the most common chronic diseases of childhood. Recent studies have suggested that having fewer siblings was associated with allergic rhinitis and atopic diseases in children. Previous studies also indicated that older siblings was associated with higher incidence of allergic rhinitis.Objectives To assess for a possible association between number of siblings and allergic rhinitis and to assess for an effect of birth order on allergic rhinitis in children.Methods We performed a cross-sectional study among school children aged 7 to 15 years, in the West Medan District from July to August 2011. Children with moderate or high risk of allergy were included. Subjects were divided into two groups, those with <3 siblings or ≥3 siblings. Children with acute respiratory tract infections, septal deviation, choanal atresia, nasal polyps, nasal tumors, or nasal foreign body were excluded. Risk of allergy was determined using the Indonesian Pediatrics Allergy Immunology Working Group trace card scoring system. Identification of allergic rhinitis and evaluation of its severity were done by use of the International Study of Asthma and Allergies in Childhood (ISAAC core questionnaire. Allergic rhinitis was diagnosed based on history, physical examination, and anterior rhinoscopy.Results A total of 78 subjects were enrolled. Allergic rhinitis was significantly higher in children with <3 siblings than those with ≥3 siblings (OR 10.33; 95%CI 3.569 to 29.916. Furthermore, allergic rhinitis was significantly higher in first-born children than in their younger siblings (P=0.0001.Conclusion Larger number of siblings and non-first-born children are associated with lower incidence of allergic rhinitis in children.

  10. Number of siblings and allergic rhinitis in children

    Directory of Open Access Journals (Sweden)

    Soewira Sastra

    2016-01-01

    Full Text Available Background Allergic rhinitis is one of the most common chronic diseases of childhood. Recent studies have suggested that having fewer siblings was associated with allergic rhinitis and atopic diseases in children. Previous studies also indicated that older siblings was associated with higher incidence of allergic rhinitis. Objectives To assess for a possible association between number of siblings and allergic rhinitis and to assess for an effect of birth order on allergic rhinitis in children. Methods We performed a cross-sectional study among school children aged 7 to 15 years, in the West Medan District from July to August 2011. Children with moderate or high risk of allergy were included. Subjects were divided into two groups, those with <3 siblings or ≥3 siblings. Children with acute respiratory tract infections, septal deviation, choanal atresia, nasal polyps, nasal tumors, or nasal foreign body were excluded. Risk of allergy was determined using the Indonesian Pediatrics Allergy Immunology Working Group trace card scoring system. Identification of aller-allergic rhinitis and evaluation of its severity were done by use of the International Study of Asthma and Allergies in Childhood (ISAAC core questionnaire. Allergic rhinitis was diagnosed based on history, physical examination, and anterior rhinoscopy. Results A total of 78 subjects were enrolled. Allergic rhinitis was significantly higher in children with <3 siblings than those with ≥3 siblings (OR 10.33; 95%CI 3.569 to 29.916. Furthermore, allergic rhinitis was significantly higher in first-born children than in their younger siblings (P=0.0001. Conclusion Larger number of siblings and non-first-born children are associated with lower incidence of allergic rhinitis in children.

  11. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients

    NARCIS (Netherlands)

    J.G. Vinke; L.W. Severijnen; W.J. Fokkens (Wytske); A. Kleinjan (Alex)

    2000-01-01

    textabstractAllergic diseases are characterized by allergic complaints in the shock organ and specific immunoglobulin (Ig)E in serum. Literature data indicate that the nasal mucosa itself could produce at least a large part of the specific IgE in allergic rhinitis patie

  12. [Summary of the practice guideline 'allergic and non-allergic rhinitis' (first revision) from the Dutch College of General Practitioners

    NARCIS (Netherlands)

    Balen, J.A. van; Verduijn, M.M.; Sachs, A.P.; Berger, M.Y.; Lucassen, P.L.B.J.; Wiersma, T.J.; Goudswaard, A.N.

    2007-01-01

    The practice guideline 'Allergic and non-allergic rhinitis' of the Dutch College ofGeneral Practitioners has been revised based on developments that have occurred in recent years. The most important modifications are: Impermeable covers for beddings are advised only for patients with serious complai

  13. Aeroallergen spectrum of patients with child allergic rhinitis in Changsha area of China%长沙地区562例变应性鼻炎患儿变应原谱分析

    Institute of Scientific and Technical Information of China (English)

    钟竹青; 王芳; 王天生; 李亮明; 谭国林

    2011-01-01

    目的:调查长沙地区变应性鼻炎患儿的变应原分布情况及其阳性率,并分析其相关因素.方法:应用13种标准化吸入变应原对562例变应性鼻炎患儿进行变应原皮肤点刺试验,并详细采集病史资料.结果:457例呈阳性反应(81.3%),其主要变应原均为粉尘螨和屋尘螨,其次为热带螨、美洲大蠊、德国小蠊及狗毛等.花粉变应原在该组十分少见,城市儿童变应性鼻炎的患病率显著高于农村(P<0.01).结论:长沙地区变应性鼻炎患儿的主要变应原为尘螨,与居住环境有关,多数患儿可应用螨变应原进行特异性免疫治疗.变应原皮肤点刺试验应用于儿童变应性鼻炎的诊断是一种安全的方法.%Objective:To investigate aeroallergen spectrum and allergy positive rates of patients with child allergic rhinitis and analyze its related factors. Method:Skin prick test was carried out in 562 cases with child allergic rhinitis using 13 inhaled allergens, and detailed history was collected in all cases. Result: Four hundred and fifty-seven (81. 3%) of 562 cases showed positive reaction to at least one allergen out of 13 allergens. The most common allergens found in patients was dermatophagoides farinae and dermatophagoides pteronyssinus,and positive reaction was 93. 1% in child allergic rhinitis, followed by tropical mite, periplaneta americana, blattella germanica and dog hair. The pollen allergen, most common in American and European, was pretty rare in this study. The prevalence of child allergic rhinitis was significantly higher in urban than in rural(P<0. 01). There was no adverse effect appeared in children with allergic rhinitis underwent skin prick test. Conclusion: The major allergen of allergic rhinitis is mite for child allergic rhinitis, and relates to housing enviroment. Most of patients with child allergic rhinitis can be treated by the mite specific immunotherapy. The skin prick test is a safe technique for diagnosis of

  14. The effect of generalist and specialist care on quality of life in asthma patients with and without allergic rhinitis

    DEFF Research Database (Denmark)

    Harmsen, Lotte; Nolte, Hendrik; Backer, Vibeke

    2010-01-01

    Treatment of asthma and rhinitis patients is often provided by both generalists (GPs) and specialists (SPs). Studies have shown differences in clinical outcomes of treatment between these settings. The aim of this study was to evaluate the effect of GP and SP care on health-related quality of life...... (HRQoL)....

  15. The effect of generalist and specialist care on quality of life in asthma patients with and without allergic rhinitis

    DEFF Research Database (Denmark)

    Harmsen, Lotte; Nolte, Hendrik; Backer, Vibeke

    2010-01-01

    Treatment of asthma and rhinitis patients is often provided by both generalists (GPs) and specialists (SPs). Studies have shown differences in clinical outcomes of treatment between these settings. The aim of this study was to evaluate the effect of GP and SP care on health-related quality of life...

  16. Radioactive Merano SPA Treatment for Allergic Rhinitis Therapy

    Directory of Open Access Journals (Sweden)

    Desiderio Passali

    2016-01-01

    Full Text Available Allergic rhinitis is a common nasal disorder with a high impact on quality of life, high social costs in therapies, and a natural development towards asthma. Pharmacological therapy is based on several genres of medications, of which intranasal corticosteroids are currently the most widespread. Thermal water treatment has traditionally been used as adjunctive treatment for chronic rhinitis and sinusitis. The present study was carried out to assess the clinical efficacy of nasal inhalation of radioactive oligomineral water vapours from the Merano hot spring and to compare it with the clinical efficacy of mometasone furoate nasal spray. A comparative prospective study was performed in 90 allergic patients treated at Merano hot springs: a group of 54 subjects treated with radioactive thermal oligomineral water and a control group of 36 subjects treated with mometasone nasal spray. Patients of both groups were assessed before and after treatment by Sino-Nasal Outcome Test questionnaire, active anterior rhinomanometry with flow and resistance monitoring, measurement of mucociliary transport time, and cytological examination of nasal brushing/scraping. The study showed that inhalation treatment with radioactive hydrofluoric thermal water for two weeks produces an objective clinical and cytological improvement in allergic patients, similar to that obtained with mometasone furoate nasal spray.

  17. Radioactive Merano SPA Treatment for Allergic Rhinitis Therapy

    Science.gov (United States)

    Gabelli, Giacomo; Passali, Giulio Cesare; Magnato, Roberto; Platzgummer, Stefan; Salerni, Lorenzo; Lo Cunsolo, Salvatore; Joos, Alexandra; Bellussi, Luisa Maria

    2016-01-01

    Allergic rhinitis is a common nasal disorder with a high impact on quality of life, high social costs in therapies, and a natural development towards asthma. Pharmacological therapy is based on several genres of medications, of which intranasal corticosteroids are currently the most widespread. Thermal water treatment has traditionally been used as adjunctive treatment for chronic rhinitis and sinusitis. The present study was carried out to assess the clinical efficacy of nasal inhalation of radioactive oligomineral water vapours from the Merano hot spring and to compare it with the clinical efficacy of mometasone furoate nasal spray. A comparative prospective study was performed in 90 allergic patients treated at Merano hot springs: a group of 54 subjects treated with radioactive thermal oligomineral water and a control group of 36 subjects treated with mometasone nasal spray. Patients of both groups were assessed before and after treatment by Sino-Nasal Outcome Test questionnaire, active anterior rhinomanometry with flow and resistance monitoring, measurement of mucociliary transport time, and cytological examination of nasal brushing/scraping. The study showed that inhalation treatment with radioactive hydrofluoric thermal water for two weeks produces an objective clinical and cytological improvement in allergic patients, similar to that obtained with mometasone furoate nasal spray.

  18. Poor reproducibility of allergic rhinitis SNP associations.

    Directory of Open Access Journals (Sweden)

    Daniel Nilsson

    Full Text Available Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR, but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls and one Singapore Chinese population (948 AR-cases, 580 controls were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.

  19. Citizen science based symptom scores of allergic rhinitis to validate the grass pollen hay fever forecast

    NARCIS (Netherlands)

    Weger, L.A.; Bas Hofstee, H.; Vliet, van A.J.H.; Hiemstra, P.S.; Sont, Jacob K.

    2015-01-01

    Introduction: On average 23% of the European population suffers from allergic rhinitis of which pollen is a major cause. Hay fever symptom forecasts can help these patients to adapt their behaviour and to take their medication in time. We developed the LUMC hay fever forecast for grass pollen allerg

  20. Noninterventional open-label trial investigating the efficacy and safety of ectoine containing nasal spray in comparison with beclomethasone nasal spray in patients with allergic rhinitis.

    Science.gov (United States)

    Sonnemann, Uwe; Möller, Marcus; Bilstein, Andreas

    2014-01-01

    Objectives. The current study aimed to compare the efficacy and safety of a classical anti-inflammatory beclomethasone nasal spray in comparison to a physic-chemical stabilizing ectoine containing nasal spray in the treatment of allergic rhinitis. Design and Methods. This was a noninterventional, open-label, observational trial investigating the effects of beclomethasone or ectoine nasal spray on nasal symptoms and quality of life. Over a period of 14 days, patients were asked to daily document their symptoms. Efficacy and tolerability were assessed by both physicians and patients. Results. Both treatments resulted in a significant decrease of TNSS values. An equivalence test could not confirm the noninferiority of ectoine treatment in comparison with beclomethasone treatment. Although clear symptom reduction was achieved with the ectoine products, the efficacy judgment showed possible advantages for the beclomethasone group. Importantly, tolerability results were comparably good in both groups, and a very low number of adverse events supported this observation. Both treatments resulted in a clear improvement in the quality of life as assessed by a questionnaire answered at the beginning and at the end of the trial. Conclusion. Taken together, it was shown that allergic rhinitis can be safely and successfully treated with beclomethasone and also efficacy and safety were shown for ectoine nasal spray.

  1. Noninterventional Open-Label Trial Investigating the Efficacy and Safety of Ectoine Containing Nasal Spray in Comparison with Beclomethasone Nasal Spray in Patients with Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Uwe Sonnemann

    2014-01-01

    Full Text Available Objectives. The current study aimed to compare the efficacy and safety of a classical anti-inflammatory beclomethasone nasal spray in comparison to a physic-chemical stabilizing ectoine containing nasal spray in the treatment of allergic rhinitis. Design and Methods. This was a noninterventional, open-label, observational trial investigating the effects of beclomethasone or ectoine nasal spray on nasal symptoms and quality of life. Over a period of 14 days, patients were asked to daily document their symptoms. Efficacy and tolerability were assessed by both physicians and patients. Results. Both treatments resulted in a significant decrease of TNSS values. An equivalence test could not confirm the noninferiority of ectoine treatment in comparison with beclomethasone treatment. Although clear symptom reduction was achieved with the ectoine products, the efficacy judgment showed possible advantages for the beclomethasone group. Importantly, tolerability results were comparably good in both groups, and a very low number of adverse events supported this observation. Both treatments resulted in a clear improvement in the quality of life as assessed by a questionnaire answered at the beginning and at the end of the trial. Conclusion. Taken together, it was shown that allergic rhinitis can be safely and successfully treated with beclomethasone and also efficacy and safety were shown for ectoine nasal spray.

  2. Local Nasal Specific Immunotherapy for Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Passalacqua Giovanni

    2006-09-01

    Full Text Available Abstract The possibility of producing local hyposensitization by administering allergens via mucosal routes was envisaged at the beginning of 1900, and local nasal immunotherapy has been extensively studied since the 1970s. Presently, there are 21 randomized controlled trials being conducted with the most common allergens, consistently showing the clinical efficacy of local nasal immunotherapy for rhinitis. Other advantages are that it has an optimal safety profile and can be self-administered at home by the patient. Moreover, there are several data from animal models and from humans that confirm the immunomodulatory effect of intranasally administered antigens. On the other hand, local nasal immunotherapy seems to be effective only on rhinitis symptoms and requires a particular technique of administration. For these reasons, its clinical use is progressively declining in favour of the sublingual route although nasal immunotherapy is validated in official documents and remains a viable alternative to injection.

  3. Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs

    OpenAIRE

    Takeshi Nabe; Kayoko Kubota; Nobuaki Mizutani; Masanori Fujii; Tetsuya Terada; Hiroshi Takenaka; Shigekatsu Kohno

    2008-01-01

    Background: As a non-injection route for immunotherapy, local nasal immunotherapy has been examined in allergic rhinitis patients. However, it is unclear how the immunotherapy affects sneezing, biphasic nasal blockage and nasal hyperresponsiveness. Thus, we evaluated the therapeutic effects of nasal immunotherapy on the symptoms of guinea pig allergic rhinitis. Additionally, we also evaluated whether the immunotherapy relieved pollen-induced allergic conjunctivitis. Methods: Sensitized ani...

  4. Treatment of 67 Cases of Seasonal Allergic Rhinitis by Acupuncture

    Institute of Scientific and Technical Information of China (English)

    王旭; 张利; 王鹰雷; 黄国琪

    2010-01-01

    @@ Seasonal allergic rhinitis refers to a seasonal and regional allergic disease induced mainly by botanical pollen,also termed "Hay Fever" and "Pollinosis",clinically manifested by the main symptoms of itching sensation in the nose,nasal obstruction,sneezing,watery nasal discharge,conjunctival congestion,itching in the eyes,lacrimation,and asthma developed from an incessant cough in some people,or manifested by the gastrointestinal symptoms of nausea,vomiting,abdominal pain,and diarrhea,and skin eczema,urticaria,pruritus vulvae,vaginitis.The author treated 67 cases of seasonal allergic rhinitis by acupuncture from 2002 to 2004.Now,the result is summarized as follows.

  5. Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management.

    Science.gov (United States)

    Poddighe, Dimitri; Gelardi, Matteo; Licari, Amelia; Del Giudice, Michele Miraglia; Marseglia, Gian Luigi

    2016-12-26

    Chronic rhinitis is a very common disease, as the prevalence in the general population resulted to be 40%. Allergic rhinitis has been considered to be the most frequent form of chronic rhinitis, as non-allergic rhinitis has been estimated to account for 25%. However, several evidences suggested that non-allergic rhinitis have been underrated, especially in children. In pediatrics, the diagnostic definition of non-allergic rhinitis has been often limited to the exclusion of an allergic sensitization. Actually, local allergic rhinitis has been often misdiagnosed as well as mixed rhinitis has not been recognized in most cases. Nasal cytology is a diagnostic procedure being suitable for routine clinical practice with children and could be a very useful tool to characterize and diagnose non-allergic rhinitis, providing important clues for epidemiological analysis and clinical management.

  6. The influence of lifestyle intervention on patients with allergic rhinitis%生活方式干预对过敏性鼻炎患者的影响

    Institute of Scientific and Technical Information of China (English)

    吴美芝; 揭桂莲; 吴凤玲

    2014-01-01

    目的:探讨生活方式干预对过敏性鼻炎患者的影响。方法将116例过敏性鼻炎患者随机分为实验组和对照组,每组各58例,对照组给予常规对症护理,实验组在对照组的基础上给予生活方式干预,采用生活方式情况评价表、治疗效果评价表对两组患者干预前、干预1年后的生活方式情况、治疗效果进行比较。结果与干预前比较,干预1年后实验组的生活方式情况、治疗效果明显优于对照组,差异有统计学意义( P<0.05)。结论生活方式干预有利于过敏性鼻炎患者建立健康的生活方式,提高治疗效果,从而进一步提高患者的生活质量。%Objective To investigate the influence of lifestyle intervention on patients with allergic rhinitis. Methods 116 cases with allergic rhinitis were randomly divided into the experimental group and the control group, each group had 58 cases, the control group was given general symptomatic care, the experimental group was given lifestyle intervention based on the control group, compared the lifestyle and clinical efficacy of the two groups before intervention and 1 year after intervention by lifestyle evaluation form and treatment evaluation form. Results Compared with before the intervention,the lifestyle and clinical efficacy of the experimental group were significantly better than the control group 1 year after intervention.The difference had statistically significant(P < 0.05). Conclusion It is conducive to lead a healthy lifestyle for patients with allergic rhinitis by lifestyle intervention, improve the therapeutic effect, thereby further improving the patients' life quality.

  7. Treatment of 82 Cases of Allergic Rhinitis with Aconite Cake-partitioned Moxibustion

    Institute of Scientific and Technical Information of China (English)

    胡志平; 李小军; 黄克伟; 洪珏

    2010-01-01

    @@ Allergic rhinitis is mainly characterized by recurrent sneezing and runny nose.The author has treated 82 cases of allergic rhinitis with aconite cake-partitioned moxibustion and now it is reported as follows.

  8. A review of clinical efficacy, safety, new developments and adherence to allergen-specific immunotherapy in patients with allergic rhinitis caused by allergy to ragweed pollen (Ambrosia artemisiifolia)

    Science.gov (United States)

    Turkalj, Mirjana; Banic, Ivana; Anzic, Srdjan Ante

    2017-01-01

    Allergic rhinitis is a common health problem in both children and adults. The number of patients allergic to ragweed (Ambrosia artemisiifolia) is on the rise throughout Europe, having a significant negative impact on the patients’ and their family’s quality of life. Allergen-specific immunotherapy (AIT) has disease-modifying effects and can induce immune tolerance to allergens. Both subcutaneous immunotherapy and sublingual immunotherapy with ragweed extracts/preparations have clear positive clinical efficacy, especially over pharmacological treatment, even years after the treatment has ended. AIT also has very good safety profiles with extremely rare side effects, and the extracts/preparations used in AIT are commonly well tolerated by patients. However, patient adherence to treatment with AIT seems to be quite low, mostly due to the fact that treatment with AIT is relatively time-demanding and, moreover, due to patients not receiving adequate information and education about the treatment before it starts. AIT is undergoing innovations and improvements in clinical efficacy, safety and patient adherence, especially with new approaches using new adjuvants, recombinant or modified allergens, synthetic peptides, novel routes of administration (epidermal or intralymphatic), and new protocols, which might make AIT more acceptable for a wider range of patients and novel indications. Patient education and support (eg, recall systems) is one of the most important goals for AIT in the future, to further enhance treatment success.

  9. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis

    DEFF Research Database (Denmark)

    Chawes, Bo

    2011-01-01

    Allergic- and non-allergic rhinitis are very common diseases in childhood in industrialized countries. Although these conditions are widely trivialized by both parents and physicians they induce a major impact on quality of life for the affected children and a substantial drainage of health care...... understood and there is a paucity of data objectivizing this association in young children. The aim of this thesis was to describe pathology in the upper and lower airways in young children from the COPSAC birth cohort with investigator-diagnosed allergic- and non-allergic rhinitis. Nasal congestion is a key...... children may contribute to the discovery of new mechanisms involved in pathogenesis and help direct future research to develop correctly timed preventive measures as well as adequate monitoring and treatment of children with rhinitis. Asthma is a common comorbidity in subjects with allergic rhinitis...

  10. Diagnosis and clinical characteristics of patients with non-allergic rhinitis%非变应性鼻炎的诊断及临床特征分析

    Institute of Scientific and Technical Information of China (English)

    王洪田; 张静; 尤少华; 奥彦云; 白银; 石怀银; 籍灵超; 贾婧杰; 张悦

    2014-01-01

    Objective To explore a step-by-step exclusive diagnosis and analyze the clinical characters of non-allergic rhinitis (NAR).Methods Patients with symptoms (nasal itching,sneezing,rhinorrhea,nasal congestion) were selected to take four-step exclusive diagnosis for NAR.The false NAR was eliminated and the true NAR was retained.First step was to exclude the patients who were not suitable for skin prick test (SPT,such as during pregnancy,breastfeeding,asthma,oral antihistamine medication in 7 day,severe skin diseases).The second step was to exclude the patients with positive SPT and the third step was to exclude the patients with 1 level or above of specific seroimmunoglobulin E (sIgE).The fourth step was to exclude the patients with infection rhinitis,clear abnormal nasal structure,drug-induced rhinitis,nasal neoplasm.The remained patients were finally diagnosed as NAR and who were further differential diagnosed as vasomotor rhinitis (VMR) or non-allergic rhinitis with eosinophilia syndrome (NARES) according to the eosinophilia counts in nasal secretion and venous blood.The common characters of patients with NAR were analyzed and their symptoms and quality of life were evaluated by visual analogue scale (VAS) and rhino-conjunctivitis quality of life questionnaire (RQLQ) separately.Results One thousand four hundred and thirty-seven patients were included after first step exclusion and 735 cases with negative SPT were remained after second step exclusion.Of 735 patients,302 were tested in vitro for sIgE and 93 cases with 0 level of sIgE and total IgE were remained after third step exclusion.Sixty-two patients were finally diagnosed as NAR after fourth step exclusion.The NAR diagnosis rate was 51.15% (735/1 437) with negative SPT alone and the NAR diagnosis rate was 29.06% (93/302) with combination of negative SPT and sIgE.Of 62 patients with NAR,47 patients (75.81%) were diagnosed as VMR and 15 cases (24.19%) as NARES.There were 23 males and 39 females in the 62

  11. Association between allergic rhinitis and hospital resource use among asthmatic children in Norway

    DEFF Research Database (Denmark)

    Sazonov Kocevar, V; Thomas, J; Jonsson, L;

    2005-01-01

    of concomitant allergic rhinitis on asthma-related hospital resource utilization among children below 15 years of age with asthma in Norway. METHODS: A population-based retrospective cohort study of children (aged 0-14 years) with asthma was conducted using data from a patient-specific public national database......BACKGROUND: Preliminary evidence suggests that inadequately controlled allergic rhinitis in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. The objective of this study was therefore to assess the effect...... of hospital admissions during a 2-year period, 1998-1999. Multivariate linear regression, adjusting for risk factors including age, gender, year of admission, urban/rural residence and severity of asthma episode, estimated the association between allergic rhinitis and total hospital days. A multivariate Cox...

  12. House dust mite induced allergic rhinitis in children in primary care : Epidemiology and Management

    NARCIS (Netherlands)

    C.M.A. de Bot (Cindy)

    2012-01-01

    textabstractAllergic rhinitis (AR) is an allergen-induced, upper-airway inflammatory disease. The characteristic symptoms of allergic rhinitis are a runny nose, sneezing, congestion, redness of the eyes, watering eyes, and itching of the eyes, nose and throat. Previously, allergic rhinitis was subdi

  13. How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement

    DEFF Research Database (Denmark)

    Bousquet, J; Schünemann, H J; Bousquet, P J;

    2011-01-01

    Specific immunotherapy (SIT) is one of the treatments for allergic rhinitis. However, for allergists, nonspecialists, regulators, payers, and patients, there remain gaps in understanding the evaluation of randomized controlled trials (RCTs). Although treating the same diseases, RCTs in SIT...

  14. Clinical Experience in Acupuncture Treatment of Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yan-qiu

    2009-01-01

    Objective:To observe the clinical effects of acupuncture for allergic rhinitis.Methods:The body acupuncture, auricular seed-embedding and microwave irradiation were adopted for treatment of allergic rhinitis due to various causative factors, such as cold and insufficiency of the lung-qi weakening the body resistance, insufficiency of the spleen-qi with lucid yang failing to rise, insufficiency of the kidney-yang failing to warm the body surface, and the heat accumulated in the lung channels giving invading the nose.Results:After treatment, the symptoms and signs disappeared in all illustrative cases, with no recurrence found after a one-year follow-up.Conclusion:Acupuncture may help to improve the blood rheology indexes with an increased volume of blood flow, and regulate the immunological function of the human body, thus giving therapeutic effects for allergic rhinitis.

  15. Does allergic rhinitis affect communication skills in young adults?

    Science.gov (United States)

    Cingi, Can Cemal; Sakallıoğlu, Öner; Muluk, Nuray Bayar; Cingi, Cemal

    2016-01-01

    Allergic rhinitis (AR) is a chronic disorder with a high prevalence in the general population. The symptoms of AR can impair the cognitive capabilities of the affected people. The study of communication skills and AR interaction has not been adequately discussed. We aimed to analyze Social Communication Skills of university students with AR. Fifty patients suffering from AR and 50 healthy subjects were studied. All participants completed two questionnaires [Social Communication Skills Rating Scale (SCSRS) and Communication Questionnaire] for the assessment of social communication skills. Total scores of both SCSRS and Communication Questionnaire were higher in participants with AR than controls. When the questions of SCSRS were compared between the groups one by one, significant difference was observed between the groups for questions numbered 1-9 and 11, 12 (p Communication Questionnaire (p communication skills of the patients with AR. More research is however needed to validate this hypothesis.

  16. 海南省蜉蝣过敏原临床致敏性%Allergenicity of Ephemeroptera Allergen in Allergic Rhinitis Patients of Hainan Province

    Institute of Scientific and Technical Information of China (English)

    孟光; 刘硕; 李春林; 谢伟伟; 张淑芳; 蔡琼香; 邓晓聪

    2011-01-01

    目的 了解海南省临床蜉蝣过敏情况,为过敏性鼻炎的流行病学研究及临床诊断、治疗和预防提供依据.方法 对500例过敏性鼻炎患者用蜉蝣过敏原进行前臂皮肤点刺试验,然后随机选择20例蜉蝣点刺阳性患者进行蜉蝣过敏原鼻黏膜激发试验.结果 500例皮肤点刺试验中,蜉蝣阳性者占58.6%(293/500),20例阴性对照者皮肤点刺均为阴性100%(20/20);20例蜉蝣皮肤点刺阳性患者中过敏原鼻黏膜激发试验阳性者为20例(100%),20例阴性对照未见阳性反应.结论 皮肤点刺和过敏原鼻黏膜激发试验结果相符合,蜉蝣为海南省重要过敏原.%Objective To investigate the allergenicity of Ephemeroptera allergen in allergic rhinitis (AR) patients of Hainan province, as a basis for epidemiological survey, clinical diagnosis, treatment and prevention. Methods 500 patients with allergic rhinitis were detected with Ephemeroptera allergen extract by skin prick test (SPT), and 20 cases of the SPT positive patients were chosen randomly to be prescribed the nasal provocation test. Allergen extract was produced by Beijing MacroUnion Pharmaceutical Co. ,Ltd. Results 293 cases in AR group showed positive SPT results; the positive rate was 58.6% (293/500). All the SPT results were negative in 20 cases in control group; the negative rate was 100% (20/20). All the nasal provocation test results were positive in 20 cases positive SPT patients, while all negative in 20 cases of control group. Conclusion The SPT results were shown to accord with the results of nasal provocation test. Ephemeropterais one kind of important inhalant allergens in Hainan province, which provide evidence as a basis for clinical diagnosis, treatment, prevention and specific immunotherapy in allergic disease patients in Hainan province.

  17. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

    NARCIS (Netherlands)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W; Arnavielhe, Sylvie; Bachert, Claus; Bedbrook, Anna; Bergmann, Karl-Christian; Bosnic-Anticevich, Sinthia; Brozek, Jan; Calderon, Moises; Canonica, G Walter; Casale, Thomas B; Chavannes, Niels H; Cox, Linda; Chrystyn, Henry; Cruz, Alvaro A; Dahl, Ronald; De Carlo, Giuseppe; Demoly, Pascal; Devillier, Phillipe; Dray, Gérard; Fletcher, Monica; Fokkens, Wytske J; Fonseca, Joao; Gonzalez-Diaz, Sandra N; Grouse, Lawrence; Keil, Thomas; Kuna, Piotr; Larenas-Linnemann, Désirée; Lodrup Carlsen, Karin C; Meltzer, Eli O; Mullol, Jaoquim; Muraro, Antonella; Naclerio, Robert N; Palkonen, Susanna; Papadopoulos, Nikolaos G; Passalacqua, Giovanni; Price, David; Ryan, Dermot; Samolinski, Boleslaw; Scadding, Glenis K; Sheikh, Aziz; Spertini, François; Valiulis, Arunas; Valovirta, Erkka; Walker, Samantha; Wickman, Magnus; Yorgancioglu, Arzu; Haahtela, Tari; Zuberbier, Torsten; Smit, HA

    2016-01-01

    The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical d

  18. Allergic Sensitization, Rhinitis and Tobacco Smoke Exposure in US Adults.

    Directory of Open Access Journals (Sweden)

    Josef Shargorodsky

    Full Text Available Tobacco exposure has been linked with sinonasal pathology and may be associated with allergic sensitization. This study evaluates the association between exposure to active smoking or secondhand smoke (SHS and the prevalence of rhinitis and allergic sensitization in the US adult population.Cross-sectional study in 4,339 adults aged 20-85 in the National Health and Nutrition Examination Survey, 2005-2006. Never smoking was defined as reported lifetime smoking less than 100 cigarettes and serum cotinine levels 10 ng/mL. Self-reported rhinitis was based on symptoms during the past 12 months, and allergen sensitization was defined as a positive response to any of the 19 specific IgE antigens tested.Almost half of the population (43% had detectable levels of IgE specific to at least one inhaled allergen and 32% reported a history of rhinitis. After multivariate adjustment, there was a statistically significant association between the highest serum cotinine tertile and rhinitis in active smokers (OR 1.42; 95%CI 1.00-2.00. The association between active smoking and rhinitis was stronger in individuals without allergic sensitization (OR 2.47; 95%CI 1.44-4.23. There was a statistically significant association between increasing cotinine tertiles and decreased odds of inhaled allergen sensitization (p-trend <.01.Tobacco smoke exposure was associated with increased prevalence of rhinitis symptoms, but not with allergic sensitization. The results indicate that the relationship between tobacco smoke exposure and sinonasal pathology in adults may be independent of allergic sensitization.

  19. Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior.

    Science.gov (United States)

    Fang, Beverly J; Tonelli, Leonardo H; Soriano, Joseph J; Postolache, Teodor T

    2010-01-01

    Allergic inflammation is associated with mood disorders, exacerbation of depression, and suicidal behavior. Mediators of inflammation modulate sleep , with Th1 cytokines promoting NREM sleep and increasing sleepiness and Th2 cytokines (produced during allergic inflammation) impairing sleep. As sleep impairment is a rapidly modifiable suicide risk factor strongly associated with mood disorders, we review the literature leading to the hypothesis that allergic rhinitis leads to mood and anxiety disorders and an increased risk of suicide via sleep impairment. Specifically, allergic rhinitis can impair sleep through mechanical (obstructive) and molecular (cytokine production) processes. The high prevalence of mood and anxiety disorders and allergy, the nonabating suicide incidence, the currently available treatment modalities to treat sleep impairment and the need for novel therapeutic targets for mood and anxiety disorders, justify multilevel efforts to explore disturbance of sleep as a pathophysiological link.

  20. Quality of Sexual Life in Males with Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Gul Soylu Ozler

    2014-12-01

    Full Text Available Aim: The aim of this study is to evaluate the quality of sexual life of males with allergic rhinitis(AR. Material and Method: 40 patients with AR diagnosed with skin prick test and 40 control subjects with no evidence of allergy completed the study. International Index of Erectile Function questionnaire (IIEF was used to evaluate the quality of sexual life of the subjects. Results: The mean scores of erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction for AR group were significantly lower than control group(p=0.0001. Discussion: AR has negative effects on quality of life. The effective treatment of AR by the clinician will also avoid these concomitting social, sexual and sleep disturbances.

  1. 活化嗜碱粒细胞在变应性鼻炎患者外周血中的表达%Expression of activated basophile in peripheral blood in patients with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    张淳; 石嘉俪; 徐雅男; 王利民; 王家东

    2011-01-01

    目的 探讨嗜碱粒细胞在变应性鼻炎患者外周血中数量及活化率的变化及其临床意义.方法 以化学诱导趋向性受体单抗作为特异性的荧光标记,采用三色免疫荧光标记流式细胞术对20例急性发作期变应性鼻炎患者(急性组)、20例反复发作变应性鼻炎患者(慢性组)及30例健康者(对照组)的外周血嗜碱粒细胞及其活化率进行定量检测.结果 慢性组外周血化学诱导趋向性受体及嗜碱粒细胞高于急性组(P<0.01)和对照组(P<0.05),对照组高于急性组(P<0.01).慢性组与急性组嗜碱粒细胞活化率均高于对照组(P<0.01).结论 嗜碱粒细胞活化是导致变应性鼻炎症状出现的主要因素之一.慢性期患者嗜碱粒细胞的持续增高和活化可能与变应性鼻炎反复发作有关.%Objective To evaluate the number and the activation rate of basophile in peripheral blood in patients with allergic rhinitis and their clinical significance. Methods The chemoattractant receptor-homologus molecule expressed on T helper cells was used as a specific fluorescent marker. Twenty patients with acute allergic rhinitis, 20 patients with chronic allergic rhinitis and 30 healthy controls were evaluated the number and the activation rate of basophile in peripheral blood with three-color fluorescent flow cytometry analysis. Results The numbers of chemoattractant receptor-homologus molecule expressed on T helper cells and basophile were significantly larger in chronic allergic rhinitis group than those in acute allergic rhinitis group (P<0. 01) and normal group (P< 0. 05). The activation rate of basophile was significantly higher in acute allergic rhinitis and chronic allergic rhinitis group than that in control group(P<0. 01). Conclusion The activation of basophile is one of the main factors inducing the symptoms of allergic rhinitis. The continuous increase of the number and the activation rate of basophile may be involved in

  2. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine.

    Science.gov (United States)

    Wang, Xue Yan; Lim-Jurado, Margaret; Prepageran, Narayanan; Tantilipikorn, Pongsakorn; Wang, De Yun

    2016-01-01

    Allergic rhinitis and urticaria are common allergic diseases that may have a major negative impact on patients' quality of life. Bilastine, a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. This agent does not interact with the cytochrome P450 system and does not undergo significant metabolism in humans, suggesting that it has very low potential for drug-drug interactions, and does not require dose adjustment in renal impairment. As bilastine is not metabolized and is excreted largely unchanged, hepatic impairment is not expected to increase systemic exposure above the drug's safety margin. Bilastine has demonstrated similar efficacy to cetirizine and desloratadine in patients with seasonal allergic rhinitis and, in a Vienna Chamber study, a potentially longer duration of action than fexofenadine in patients with asymptomatic seasonal allergic rhinitis. It has also shown significant efficacy (similar to that of cetirizine) and safety in the long-term treatment of perennial allergic rhinitis. Bilastine showed similar efficacy to levocetirizine in patients with chronic spontaneous urticaria and can be safely used at doses of up to fourfold higher than standard dosage (80 mg once daily). The fourfold higher than standard dose is specified as an acceptable second-line treatment option for urticaria in international guidelines. Bilastine is generally well tolerated, both at standard and at supratherapeutic doses, appears to have less sedative potential than other second-generation antihistamines, and has no cardiotoxicity. Based on its pharmacokinetic properties, efficacy, and tolerability profile, bilastine will be valuable in the management of allergic rhinitis and urticaria.

  3. Observation on Therapeutic Effects of Cupping Therapy for Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    许荣正; 朱雪兰; 吴国民; 黄国琪

    2010-01-01

    @@ Allergic rhinitis is mainly characterized by the symptoms of sneezing,tickling sensation in the nose,runny nose,and nasal obstruction,and often occurs after invasion of pathogenic wind and cold.The author has treated 50 cases of this disease by applying cupping therapy on Shenque (CV 8).Now,the report is given as follows.

  4. Treating allergic rhinitis with depot-steroid injections increase risk of osteoporosis and diabetes

    DEFF Research Database (Denmark)

    Aasbjerg, Kristian; Torp-Pedersen, Christian; Vaag, Allan

    2013-01-01

    In Denmark, 23% of the adult population have allergic rhinitis. We have previously demonstrated that a majority of hay fever patients are treated with depot-steroid injections in violation of the guidelines. It has been hypothesised that 1-2 annual depot-steroid injections are not harmful...

  5. Inconclusive evidence for allergic rhinitis to predict a prolonged or chronic course of acute rhinosinusitis

    NARCIS (Netherlands)

    Frerichs, K.A.; Nigten, G.; Romeijn, K.; Kaper, N.M.; Grolman, W.; van der Heijden, G.J.M.G.

    2014-01-01

    Objective To systematically review the evidence on allergic rhinitis as a predictor for a prolonged or chronic course in adult patients with acute rhinosinusitis. Data Sources Pubmed, EMBASE, and the Cochrane library. Review Methods A systematic literature search was performed on March 15, 2013. Dur

  6. Specific immunotherapy can greatly reduce the need for systemic steroids in allergic rhinitis

    DEFF Research Database (Denmark)

    Aasbjerg, Kristian; Torp-Pedersen, C; Backer, V

    2012-01-01

    Worldwide, more than 400 million individuals have allergic rhinitis, which has a significant impact on the individual's general health. Most patients self-medicate with over-the-counter drugs, but severe cases need treatment with topical corticosteroids and/or immunotherapy (SCIT). Although the A...

  7. Acupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol

    Directory of Open Access Journals (Sweden)

    Kang Kyung-Won

    2009-07-01

    Full Text Available Abstract Background Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects of conventional medication. Acupuncture has been widely used to treat patients with allergic rhinitis, but the available evidence of its effectiveness is insufficient. Our objective is to evaluate the effectiveness of acupuncture in patients in Korea and China with persistent allergic rhinitis compared to sham acupuncture treatment or waitlist control. Methods This study consists of a multi-centre (two centres in Korea and two centres in China, randomised, controlled trial with three parallel arms (active acupuncture, sham acupuncture, and waitlist group. The active acupuncture and sham acupuncture groups will receive real or sham acupuncture treatment, respectively, three times per week for a total of 12 sessions over four weeks. Post-treatment follow-up will be performed a month later to complement these 12 acupuncture sessions. Participants in the waitlist group will not receive real or sham acupuncture treatments during this period but will only be required to keep recording their symptoms in a daily diary. After four weeks, the same treatment given to the active acupuncture group will be provided to the waitlist group. Discussion This trial will provide evidence for the effectiveness of acupuncture as a treatment for persistent allergic rhinitis. The primary outcome between groups is a change in the self-reported total nasal symptom score (i.e., nasal obstruction, rhinorrhea, sneezing, and itching from baseline at the fourth week. Secondary outcome measures include the Rhinitis Quality of Life Questionnaire score and total non-nasal symptom score (i.e., headache, itching, pain, eye-dropping. The quantity of conventional relief medication used during the follow-up period is another secondary outcome measure. Trial

  8. Prevalence of sensitivity to cockroach allergens and IgE crossreactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma

    Institute of Scientific and Technical Information of China (English)

    SUN Bao-qing; LAI Xu-xin; Birgitte Gjesing; Michael Dho Spangfort; ZHONG Nan-shan

    2010-01-01

    Background Cockroaches are an important indoor allergen source causing allergic rhinitis and asthma. The aim of this study was to investigate the cockroach prevalence in mainland of China and the cross-reactivity of IgE between cockroach and house dust mite allergen in Chinese patients.Methods The cockroach sensitization pattern was based on a skin prick test (SPT) obtained from a national multicenter prevalence study, in which 6304 patients from 25 allergy centers across China participated. Factors, including different regions of China, age, gender and the correlations between the American and German cockroaches and house dust mite Der p were investigated. Eighteen out of 1236 clinical sera from south China were selected to perform the cross-inhibition assay between house dust mites and cockroaches.Results Totally 25.7% of patients were SPT positive to the American cockroach (Periplaneta Americana, Per a) and 18.7% SPT positive to the German cockroach (Blattella germanica, Bla g). The prevalence of positive cockroach SPT was higher in southern than in northern China, higher in adults than in children, and higher in males than in females.Patients had relatively low levels of cockroach SPT reactions, mainly class 1 or 2. Of the SPT positive cockroach patients,88% were also SPT positive to house dust mite (Dermatophagoides pteronyssinus, Der p). An IgE cross-inhibition study confirmed that Der P sensitization could cause false positive SPT reactions against cockroach.Conclusions A relatively high prevalence of cockroach sensitivity was found in mainland of China. However, a cross-inhibition study showed that only a small number of patients appear to have Bla g and/or Per a as primary sensitizing source. The importance of cockroaches as a risk factor for sensitization and triggers of allergic symptoms in mainland of China needs to be further investigated.

  9. Relation between air pollution and allergic rhinitis in Taiwanese schoolchildren

    Directory of Open Access Journals (Sweden)

    Lee Yung-Ling

    2006-02-01

    Full Text Available Abstract Background Recent findings suggest that exposure to outdoor air pollutants may increase the risk of allergic rhinitis. The results of these studies are inconsistent, but warrant further attention. The objective of the study was to assess the effect of relation between exposure to urban air pollution and the prevalence allergic rhinitis among school children. Methods We conducted a nationwide cross-sectional study of 32,143 Taiwanese school children. We obtained routine air-pollution monitoring data for sulphur dioxide (SO2, nitrogen oxides (NOx, ozone (O3, carbon monoxide (CO, and particles with an aerodynamic diameter of 10 μm or less (PM10. A parent-administered questionnaire provided information on individual characteristics and indoor environments (response rate 92%. Municipal-level exposure was calculated using the mean of the 2000 monthly averages. The effect estimates were presented as odds ratios (ORs per 10 ppb change for SO2, NOx, and O3, 100 ppb change for CO, and 10 μg/m3 change for PM10. Results In two-stage hierarchical model adjusting for confounding, the prevalence of allergic rhinitis was significantly associated with SO2 (adjusted odds ratio (OR = 1.43, 95% confidence interval (CI: 1.25, 1.64, CO (aOR = 1.05, 95% CI: 1.04, 1.07, and NOx (aOR = 1.11, 95% CI: 1.08, 1.15. Contrary to our hypothesis, the prevalence of allergic rhinitis was weakly or not related to O3 (aOR = 1.05, 95% CI: 0.98, 1.12 and PM10 (aOR = 1.00, 95% CI: 0.99, 1.02. Conclusion Persistent exposure to NOx, CO, and SO2 may increase the prevalence of allergic rhinitis in children.

  10. ANALYSIS OF CONDITION CONTROL IN ASTHMA PATIENTS WITH ALLERGIC RHINITIS%合并变应性鼻炎的支气管哮喘病情控制分析

    Institute of Scientific and Technical Information of China (English)

    陈海珍; 郭百凌; 张建霞; 张金春; 焦方刚

    2012-01-01

    [目的]分析合并变应性鼻炎的支气管哮喘患者病情控制情况和肺通气功能.[方法]对入选的无其他心肺疾病、糖尿病和职业病的住院支气管哮喘患者,分单纯支气管哮喘组(单纯哮喘组)和合并变应性鼻炎组(鼻炎组)两组,进行病例对照研究,以问卷形式调查哮喘控制情况,以肺功能仪测定肺活量(VC)、一秒呼气/用力肺活量(FEV1%)和最大分钟通气量(MVV),建立个人数据库,对数据进行统计分析.[结果]275例支气管哮喘患者中鼻炎组126例,占45.8%,其发作频率、近1年住院次数和每次住院天数均高于单纯哮喘组,且差异有统计学意义(P<0 05);哮喘控制测试分值差于单纯哮喘组,且差异有统计学意义(P<0 05);鼻炎组VC、FEV1%和MVV均低于单纯哮喘组,差异有统计学意义(P<0.05).[结论]变应性鼻炎的控制情况影响支气管哮喘的发作和肺通气功能,临床工作中要高度重视支气管哮喘患者有无合并变应性鼻炎并规范化治疗.%[ObjeCtive] To analyze condition control and lung function in asthma patients with allergic rhinitis. [Meth-ods] A total of 275 aslhma patients admitted to hospital without cardiopulmonaiy disease, diabetes and occupational disease. Cases of asthma were classified as asthma and asthma with allergic rhinitis and their characteristics were compared. The ques-tionnaire survey was carried out, values of vital capacity (VC), forced expiratory volume in 1 second (FEV1%) and maximal ventilatory volume/minute (MVV) were obtained by measurements of lung function, and demographic and clinical data were collected and analyzed. [Results] Allergic rhinitis occurred in 126 (45.8%) of asthma patients. Aslhma patients with allergic rhinitis presented higher frequency of asthma, experienced more hospitalizalions in a year and longer hospital days than asthma patients without allergic rhinitis, with poorer scores in asthma control (P < 0.05). The lung

  11. Allergic Rhinitis and its Impact on Asthma (ARIA) : Achievements in 10 years and future needs

    NARCIS (Netherlands)

    Bousquet, J.; Schuenemann, H. J.; Samolinski, B.; Demoly, P.; Baena-Cagnani, C. E.; Bachert, C.; Bonini, S.; Boulet, L. P.; Bousquet, P. J.; Brozek, J. L.; Canonica, G. W.; Casale, T. B.; Cruz, A. A.; Fokkens, W. J.; Fonseca, J. A.; van Wijk, R. Gerth; Grouse, L.; Haahtela, T.; Khaltaev, N.; Kuna, P.; Lockey, R. F.; Carlsen, K. C. Lodrup; Mullol, J.; Naclerio, R.; O'Hehir, R. E.; Ohta, K.; Palkonen, S.; Papadopoulos, N. G.; Passalacqua, G.; Pawankar, R.; Price, D.; Ryan, D.; Simons, F. E. R.; Togias, A.; Williams, D.; Yorgancioglu, A.; Yusuf, O. M.; Aberer, W.; Adachi, M.; Agache, I.; Ait-Khaled, N.; Akdis, C. A.; Andrianarisoa, A.; Annesi-Maesano, I.; Ansotegui, I. J.; Baiardini, I.; Bateman, E. D.; Bedbrook, A.; Beghe, B.; Beji, M.; Bel, E. H.; Ben Kheder, A.; Bennoor, K. S.; Bergmann, K. C.; Berrissoul, F.; Bieber, T.; Jensen, C. Bindslev; Blaiss, M. S.; Boner, A. L.; Bouchard, J.; Braido, F.; Brightling, C. E.; Bush, A.; Caballero, F.; Calderon, M. A.; Calvo, M. A.; Camargos, P. A. M.; Caraballo, L. R.; Carlsen, K. H.; Carr, W.; Cepeda, A. M.; Cesario, A.; Chavannes, N. H.; Chen, Y. Z.; Chiriac, A. M.; Chivato Perez, T.; Chkhartishvili, E.; Ciprandi, G.; Costa, D. J.; Cox, L.; Custovic, A.; Dahl, R.; Darsow, U.; De Blay, F.; Deleanu, D.; Denburg, J. A.; Devillier, P.; Didi, T.; Dokic, D.; Dolen, W. K.; Douagui, H.; Dubakiene, R.; Durham, S. R.; Dykewicz, M. S.; El-Gamal, Y.; El-Meziane, A.; Emuzyte, R.; Fiocchi, A.; Fletcher, M.; Fukuda, T.; Gamkrelidze, A.; Gereda, J. E.; Gonzalez Diaz, S.; Gotua, M.; Guzman, M. A.; Hellings, P. W.; Hellquist-Dahl, B.; Horak, F.; Hourihane, J. O'B.; Howarth, P.; Humbert, M.; Ivancevich, J. C.; Jackson, C.; Just, J.; Kalayci, O.; Kaliner, M. A.; Kalyoncu, A. F.; Keil, T.; Keith, P. K.; Khayat, G.; Kim, Y. Y.; N'Goran, B. Koffi; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kvedariene, V.; Larenas-Linnemann, D.; Le, L. T.; Lemiere, C.; Li, J.; Lieberman, P.; Lipworth, B.; Mahboub, B.; Makela, M. J.; Martin, F.; Marshall, G. D.; Martinez, F. D.; Masjedi, M. R.; Maurer, M.; Mavale-Manuel, S.; Mazon, A.; Melen, E.; Meltzer, E. O.; Mendez, N. H.; Merk, H.; Mihaltan, F.; Mohammad, Y.; Morais-Almeida, M.; Muraro, A.; Nafti, S.; Namazova-Baranova, L.; Nekam, K.; Neou, A.; Niggemann, B.; Nizankowska-Mogilnicka, E.; Nyembue, T. D.; Okamoto, Y.; Okubo, K.; Orru, M. P.; Ouedraogo, S.; Ozdemir, C.; Panzner, P.; Pali-Schoell, I.; Park, H. S.; Pigearias, B.; Pohl, W.; Popov, T. A.; Postma, D. S.; Potter, P.; Rabe, K. F.; Ratomaharo, J.; Reitamo, S.; Ring, J.; Roberts, R.; Rogala, B.; Romano, A.; Rodriguez, M. Roman; Rosado-Pinto, J.; Rosenwasser, L.; Rottem, M.; Sanchez-Borges, M.; Scadding, G. K.; Schmid-Grendelmeier, P.; Sheikh, A.; Sisul, J. C.; Sole, D.; Sooronbaev, T.; Spicak, V.; Spranger, O.; Stein, R. T.; Stoloff, S. W.; Sunyer, J.; Szczeklik, A.; Todo-Bom, A.; Toskala, E.; Tremblay, Y.; Valenta, R.; Valero, A. L.; Valeyre, D.; Valiulis, A.; Valovirta, E.; Van Cauwenberge, P.; Vandenplas, O.; van weel, C.; Vichyanond, P.; Viegi, G.; Wang, D. Y.; Wickman, M.; Woehrl, S.; Wright, J.; Yawn, B. P.; Yiallouros, P. K.; Zar, H. J.; Zernotti, M. E.; Zhong, N.; Zidarn, M.; Zuberbier, T.

    2012-01-01

    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclas

  12. Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs

    NARCIS (Netherlands)

    Bousquet, J.; Schunemann, H.J.; Samolinski, B.; Demoly, P.; Baena-Cagnani, C.E.; Bachert, C.; Bonini, S.; Boulet, L.P.; Bousquet, P.J.; Brozek, J.L.; Canonica, G.W.; Casale, T.B.; Cruz, A.A.; Fokkens, W.J.; Fonseca, J.A.; Wijk, R.G. van; Grouse, L.; Haahtela, T.; Khaltaev, N.; Kuna, P.; Lockey, R.F.; Lodrup Carlsen, K.C.; Mullol, J.; Naclerio, R.; O'Hehir, R.E.; Ohta, K.; Palkonen, S.; Papadopoulos, N.G.; Passalacqua, G.; Pawankar, R.; Price, D.; Ryan, D.; Simons, F.E.; Togias, A.; Williams, D.; Yorgancioglu, A.; Yusuf, O.M.; Aberer, W.; Adachi, M.; Agache, I.; Ait-Khaled, N.; Akdis, C.A.; Andrianarisoa, A.; Annesi-Maesano, I.; Ansotegui, I.J.; Baiardini, I.; Bateman, E.D.; Bedbrook, A.; Beghe, B.; Beji, M.; Bel, E.H.; Ben Kheder, A.; Bennoor, K.S.; Bergmann, K.C.; Berrissoul, F.; Bieber, T.; Bindslev Jensen, C.; Blaiss, M.S.; Boner, A.L.; Bouchard, J.; Braido, F.; Brightling, C.E.; Bush, A.; Caballero, F.; Calderon, M.A.; Calvo, M.A.; Camargos, P.A.; Caraballo, L.R.; Carlsen, K.H.; Carr, W.; Cepeda, A.M.; Cesario, A.; Chavannes, N.H.; Chen, Y.Z.; Chiriac, A.M.; Chivato Perez, T.; Chkhartishvili, E.; Ciprandi, G.; Costa, D.J.; Cox, L.; Custovic, A.; Dahl, R.; Darsow, U.; Blay, F. de; Deleanu, D.; Denburg, J.A.; Devillier, P.; Didi, T.; Dokic, D.; Dolen, W.K.; Douagui, H.; Dubakiene, R.; Durham, S.R.; Dykewicz, M.S.; El-Gamal, Y.; El-Meziane, A.; Emuzyte, R.; Fiocchi, A.; Fletcher, M.; Fukuda, T.; Weel, C. van

    2012-01-01

    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclas

  13. The history and progression of treatments for allergic rhinitis.

    Science.gov (United States)

    Ostrom, Nancy K

    2014-01-01

    This article intends to place new treatments in the context of allergic rhinitis (AR) treatment history. The medical literature was searched for significant advances and changes in AR treatment. Historical data on AR treatment options and management were selected. Reviews of AR management published throughout the 20th century were included to provide context for treatment advances. Modern AR treatment began in the early 20th century with immunotherapy and was soon followed by the emergence of antihistamine therapy in the 1930s. Numerous treatments for AR have been used over the ensuing decades, including decongestants, mast cell stabilizers, and leukotriene receptor antagonists. Topical corticosteroid options were developed the 1950s, and, added to baseline antihistamine therapy, became the foundation of AR treatment. Treatment options were significantly impacted after the 1987 Montreal Protocol, which phased out the use of chlorofluorocarbon propellant aerosols because of environmental concerns. From the mid-1990s until recently, this left only aqueous solution options for intranasal corticosteroids (INSs). The approval of the first hydrofluoroalkane propellant aerosol INSs for AR in 2012 restored a "dry" aerosol treatment option. The first combination intranasal antihistamine/INSs was also approved in 2012, providing a novel treatment option for AR. Treatment of AR has progressed with new therapeutic options now available. This should continue to move forward with agents to alter the allergic mechanism itself and impact the disease burden that has a significant impact on patient outcomes.

  14. Development and validation of a 5-day-ahead hay fever forecast for patients with grass-pollen-induced allergic rhinitis.

    Science.gov (United States)

    de Weger, Letty A; Beerthuizen, Thijs; Hiemstra, Pieter S; Sont, Jacob K

    2014-08-01

    One-third of the Dutch population suffers from allergic rhinitis, including hay fever. In this study, a 5-day-ahead hay fever forecast was developed and validated for grass pollen allergic patients in the Netherlands. Using multiple regression analysis, a two-step pollen and hay fever symptom prediction model was developed using actual and forecasted weather parameters, grass pollen data and patient symptom diaries. Therefore, 80 patients with a grass pollen allergy rated the severity of their hay fever symptoms during the grass pollen season in 2007 and 2008. First, a grass pollen forecast model was developed using the following predictors: (1) daily means of grass pollen counts of the previous 10 years; (2) grass pollen counts of the previous 2-week period of the current year; and (3) maximum, minimum and mean temperature (R (2)=0.76). The second modeling step concerned the forecasting of hay fever symptom severity and included the following predictors: (1) forecasted grass pollen counts; (2) day number of the year; (3) moving average of the grass pollen counts of the previous 2 week-periods; and (4) maximum and mean temperatures (R (2)=0.81). Since the daily hay fever forecast is reported in three categories (low-, medium- and high symptom risk), we assessed the agreement between the observed and the 1- to 5-day-ahead predicted risk categories by kappa, which ranged from 65 % to 77 %. These results indicate that a model based on forecasted temperature and grass pollen counts performs well in predicting symptoms of hay fever up to 5 days ahead.

  15. ALLERGIC RHINITIS AND ADENOID HYPERTROPHY IN CHILDREN: IS ADENOIDECTOMY ALWAYS REALLY USEFUL?

    Science.gov (United States)

    Colavita, L; Miraglia Del Giudice, M; Stroscio, G; Visalli, C; Alterio, T; Pidone, C; Pizzino, M R; Arrigo, T; Chimenz, R; Salpietro, C; Cuppari, C

    2015-01-01

    Allergic rhinitis (AR) and adenoid hypertrophy (AH) are common in children and are often associated with each other. Recent studies have shown improvement of respiratory symptoms and reduction in the adenoid volume after anti-allergic medical therapy (intranasal corticosteroids, antihistamines). The aim of our retrospective study is to evaluate the effectiveness of adenoidectomy on respiratory symptoms in pediatric patients with AR. We recruited 404 pediatric patients with AR, and we divided them into 4 groups (1. intermittent-mild rhinitis; 2. intermittent-moderate/severe rhinitis; 3. persistent-mild rhinitis; 4. persistent-moderate/severe rhinitis), using ARIA classification. For each patient we evaluated: age at onset of AR; family history of allergy; the presence of other allergic diseases; serum total IgE values; skin prick test (SPT) results; presence of AH evaluated by rhino-laringeal fibroscopy; adenoidectomy and its efficacy on respiratory symptoms. Our data show an association between AR and AH: 90 of 404 (22%) children with AR had AH of a degree greater than 2nd. A significant percentage (80%) of children suffering from AR did not present satisfactory benefits from adenoidectomy. They reported persistence or recurrence of rhinitic symptoms after surgery or only partial benefits, especially of recurrent respiratory tract infections and nasal obstruction. The local allergic persistent inflammation on nasal mucosa and adenoid tissue is probably the cause of the unsatisfactory results of adenoidectomy, therefore surgery cannot be the first therapeutic step for these children. It is important to extinguish the local inflammation by medical anti-allergic therapy to obtain improvements of nasal symptoms and to prevent adenoid regrowth.

  16. New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis.

    Science.gov (United States)

    Wolthers, Ole D

    2013-09-01

    During the last few years, fixed combinations of intranasal antihistamines and corticosteroids have been introduced for treatment of allergic rhinitis. The aim of this systematic review was to assess recent patents and clinical evidence for fixed combinations of intranasal antihistamines and intranasal corticosteroids in allergic rhinitis. Data base searches revealed that intranasal combinations of the antihistamine azelastine with the corticosteroids mometasone furoate, ciclesonide and fluticasone propionate, respectively, have been patented. Four randomized, double-blinded, parallel-group, placebo-controlled, multicenter trials sponsored by the manufacturer evaluated the fixed combination of intranasal azelastine 125 µg and fluticasone propionate 50 µg administered as one dose per nostril b.i.d. in patients with moderate-to-severe symptomatic allergic rhinitis ≥ 12 years of age. Three of the studies were published as a meta-analysis which found the fixed combination of azelastine and fluticasone propionate statistically significantly more efficacious in reducing baseline total nasal symptom score by 5.7 as compared to azelastine (4.4; P antihistamines and corticosteroids are needed, especially, in primary care settings and in children before fixed combination treatment can be considered first line therapy in allergic rhinitis. Fixed combination treatment of azelastine and fluticasone propionate may offer additional benefit to selected populations of adolescents and adults with moderate-to-severe symptoms.

  17. Effect of a thromboxane A2 receptor antagonist ramatroban (BAY u 3405, on inflammatory cells, chemical mediators and non-specific nasal hyperreactivity after allergen challenge in patients with perennial allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Nobuhisa Terada

    1998-01-01

    Full Text Available In some clinical studies performed in patients with perennial allergic rhinitis, ramatroban, a new thromboxane A2 receptor antagonist, significantly improved nasal symptoms. As yet the mechanism of action of this drug has not been fully elucidated. In the present study we investigated the effects of ramatroban on changes in nasal reactivity and levels of inflammatory cells and mediators in nasal lavage fluid after allergen challenge. Ramatroban was administered orally at a daily dose of 150 mg (b.i.d. for 4 weeks to 11 patients with perennial allergic rhinitis exhibiting positive responses to nasal allergen challenge with house dust mite. Analysis of variance revealed that there was a significant decrease in eosinophil counts and eosinophil cationic protein levels in nasal lavage fluid when compared with values immediately before allergen challenge before and after ramatroban treatment. Histamine, tryptase and albumin levels were significantly decreased in analysis of variance before and after ramatroban treatment. The degree of nasal reactivity to histamine was also significantly decreased after the ramatroban treatment. These findings indicate that ramatroban decreases important pathogenic factors in allergic rhinitis, resulting in an improvement in nasal symptoms.

  18. Nasal sodium cromoglycate (Lomusol) modulates the early phase reaction of mild to moderate persistent allergic rhinitis in patients mono-sensitized to house dust mite: a preliminary study.

    Science.gov (United States)

    Lejeune, Margaux; Lefebvre, Philipe P; Delvenne, Philippe; El-Shazly, Amr E

    2015-05-01

    We evaluated the clinical improvement of patients with mild to moderate persistent allergic rhinitis (AR) due to mono-sensitization to house dust mite (HDM) allergen, by sodium cromoglycate nasal spray (Lomusol 4%). Lomusol was used as a single agent treatment, and its anti-inflammatory effects, in the early phase reaction were evaluated. Herein we showed that Lomusol significantly improved the subjective nasal symptom scores especially nasal obstruction. This was associated with significant and specific reduction in neutrophils influx in nasal cytology but had no effect on other cell types. This selective anti-inflammatory effect on nasal cytology was associated with significant reduction in the levels of platelet activating factor (PAF) and histamine in nasal secretions but had no effect on PGD2, LTC4 or CysLt levels. Lomusol was also able to induce significant reduction in eosinophil cationic protein (ECP) levels in nasal secretions without altering the percentage of eosinophil influx in nasal cytology. Taken collectively, we showed the first evidence that nasal sodium cromoglycate possesses a selective inhibition on neutrophil recruitment into nasal cytology in the early phase reaction of AR patients mono-sensitized to HDM. This may be attributed to the ability of Lomusol to significantly reduce the amount of PAF recovered in nasal secretion. These results were associated with significant improvement in subjective symptom scores especially nasal obstruction that may in addition, be due to the ability of Lomusol to down-regulate eosinophil degranulation activity as well.

  19. miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1.

    Science.gov (United States)

    Teng, Yaoshu; Zhang, Ruxin; Liu, Chunhui; Zhou, Lingling; Wang, Hong; Zhuang, Wenjie; Huang, Yu; Hong, Zhicong

    2015-01-30

    Allergic rhinitis (AR) is a common chronic inflammatory condition of the nasal mucosal tissue. The interleukin-13 (IL-13) signaling pathway is of great importance in the pathogenesis of AR. However, how the signaling molecules in this pathway are regulated, particularly through microRNAs (miRNAs), remains unclear. In the present study, we investigated the regulatory role and mechanism of miRNA-143 (miR-143) in IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells (NECs) from AR patients. Our results showed that forced expression of miR-143 significantly decreased the mRNA and protein expression levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), eotaxin and mucin 5AC (MUC5AC) in IL-13-stimulated NECs. Moreover, we confirmed that miR-143 directly targeted and significantly suppressed IL-13 receptor α1 chain (IL13Rα1) gene expression. This study thus suggests that miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in NECs from AR patients probably partly depends on inhibition of IL13Rα1. Therefore, the IL13Rα1 signaling pathway may be a potential target for the prevention and treatment of AR by miR-143.

  20. Apakah terapi pengendalian plak dapat menurunkan keparahan rinitis alergika pada anak? (Does oral plaque control therapy reduce severity of allergic rhinitis in children?

    Directory of Open Access Journals (Sweden)

    Haryono Utomo

    2005-06-01

    Full Text Available Allergic rhinitis is one of the most common ailments in children. In clinical practice approximately 50% of patients with symptoms of rhinitis are diagnosed with non-allergic rhinitis. Positive skin prick test or specific IgE in vitro tests that are relevant to aeroallergens are conclusive diagnostic of allergic rhinitis. However, simple diagnostic method such as "sneezing sign" has already proved to be reliable. Hypersensitive children have humoral immune system (Th2 which release inflammatory factors in the presence of allergen or infection that contribute to allergic response. Immunological reactions occurred and antibodies concentration arise, especially specific IgE instead of IgG because of the isotype switching. A lot of procedures such as allergen avoidance, medication and immunotherapy were done in allergic rhinitis management. However, oral plaque controls were not the point of interest in this case. The aim of this study is to find out the effectiveness of oral plaque control in the reduction of severity of allergic rhinitis symptoms using symptom scores. Fifty children, male and female aged 8–14 years, subjective diagnosed as allergic rhinitis using "sneezing sign" were included in this study. Oral plaque control procedures were done by polishing and flossing followed by 4 days of gargling with 1% povidone iodine. Clinical result showed that after 3 days, oral plaque control 2.925 times more effective than control group. The conclusion was oral plaque control is effective reducing the severity of allergic rhinitis symptoms.

  1. 变应性鼻炎与IRF5的单核苷酸多态性关系%Study on IRF5 polyMorphism in Patients with Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    冯会杰; 李文秀; 白素娟; 王德云

    2013-01-01

    Objective:To investigate the relationship oflRF5 polymorphism and allergic rhinitis.Methods:Three independent single nucleotide polymorphisms (SNP) were analyzed.The genotype and allele frequencies were detected in 110 allergic rhinitis patients and 101 health controls by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results:No statistically significant difference was detected between allergic rhinitis and controls (all P-value > 0.05).Conclusion:No association was observed between 1RF5 and allergic rhinitis in Singapore Chinese population.%目的:探讨变应性鼻炎与干扰素调节因子5(IRFS)的单核苷酸多态性(SNP)的相关性.方法:采用聚合酶链(PCR)和限制性片段长度多态性(RFL P)方法在新加坡华人中检测110例变应性鼻炎患者及101健康对照组IRF5位点上的3个单核苷酸多态性(rs4728142,rs11770589,rs2280714)计算基因型和等位基因频率.结果:IRF5基因的3个位点的基因型和等位基因频率在变应性鼻组和对照组间差异无统计学意义.结论:新加坡华人IRF5 rs4728142,rsl1770589,rs2280714多态性与变应性鼻炎无明显相关性.

  2. Analyzing of the inhaled allergens profiles of 890 allergic rhinitis patients%上海地区890例变应性鼻炎患者吸入变应原谱分析

    Institute of Scientific and Technical Information of China (English)

    丁俊杰; 张建华; 许芳; 徐颖; 朱华斌

    2012-01-01

    目的:了解上海地区变应性鼻炎患者吸入变应原分布情况,为该地区变应性鼻炎的流行病学研究和防治方案提供依据.方法:回顾分析890例门诊变应性鼻炎患者对13种吸入变应原进行皮肤点刺试验的临床资料,并比较不同年龄段及不同性别对吸入变应原阳性率的差异.结果:在上海地区变应性鼻炎患者中,最主要的吸入性变应原是屋尘螨(91.24%)、粉尘螨(86.58%)、热带螨(51.98%);其次是狗毛(15.96%),并且阳性率随年龄的增长有明显下降趋势,男女性别组间阳性率无明显差别.结论:屋尘螨、粉尘螨是上海地区变应性鼻炎最常见的变应原,变应原点刺试验有助于发现变应原,从而为脱敏治疗提供重要依据.%Objective:To investigate the inhaled allergens spectrum of 890 allergic rhinitis patients in Shanghai, and to provide basic epidemiologic information for the prevention and treatment of allergic rhinitis. Method: Thirteen allergens skin prick test results of 890 allergic rhinitis patients recruited were retrospectively analyzed. Result: The main common inhaled allergens in allergic rhinitis patients in Shanghai were house dust mite (91. 24%),dermatophagoides farinae(86. 58%) , tropical mite(51. 98%),dog hair(15. 96%). Moreover, the positive frequency was decreased with age increasing, and gender group had no obvious difference. Conclusioni House dust mite and dermatophagoides farinae were the main allergens of allergic rhinitis patients in Shanghai. Skin prick test is helpful for the discovery of the allergens so as to provide important basis of immunotherapy.

  3. Analyzing of the inhaled allergens profiles of 583 allergic rhinitis patients in district of QingPu%青浦地区变应性鼻炎患者吸入变应原检测分析

    Institute of Scientific and Technical Information of China (English)

    陈国辉; 白广平; 王丽英

    2012-01-01

    Objective To investigate the profiles of inhaled allergic rhinitis patients in district of Qingpu,and to provide basic epidetniologic information for the prevention and treatment of allergic rhinitis in this area.Methods Retrospectively analyze 14 allergens Skin prick test results of 583 allergic rhinitis patients recruited. Results the main common inhaled allergens in allergic rhinitis patients in QingPu were house dust mite(72.6%),dermatophagoides farinae(68.8%),tropical mite(41.3%),dog hair(12.7%),Moreover,the positive frequency was decreased with age increasing. Conclusion House dust mite and dermatophagoides farinae were the most common allergens in allergic rhinitis patients in QingPu area SPT is help&l for the discovery of the allergens so as to provide important basis of immunotherapy.%目的 了解青浦地区变应性鼻炎患者吸入变应原分布情况,为青浦地区变应性鼻炎的流行病学研究和防治提供重要依据.方法 回顾分析583例变应性鼻炎患者对14种吸入变应原进行皮肤点刺试验的临床资料,并比较两组年龄段及吸入变应原阳性率在分布上的差异.结果 在青浦地区变应性鼻炎患者中,最主要的吸入变应原是屋尘螨(72.6%)、粉尘螨(68.8%)、热带螨(41.3%),其次是狗毛(12.7%),并且阳性率随年龄的增长有明显下降趋势.结论屋尘螨、粉尘螨是青浦地区变应性鼻炎最常见的变应原.皮肤点刺试验(Skin Prick Test,SPT)有助于发现变应原,为免疫治疗提供重要依据.

  4. Análise de citocinas pela RT-PCR em pacientes com rinite alérgica RT-PCR cytokine study in patients with allergic rhinitis

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    Tarcimara Moreira da Silva

    2009-02-01

    Full Text Available Rinite alérgica é uma doença que decorre de um processo inflamatório da mucosa nasal conseqüente à reação de hipersensibilidade a alérgenos inalatórios e, eventualmente, alimentares. É mediada por IgE, envolvendo diferentes células, mediadores e citocinas. OBJETIVO: Avaliar as transcrições para as seguintes citocinas: IL-4, IL-5, IL-8 e IFN-gama, particularmente importantes no processo alérgico nasal, principalmente IL-4 e IL-5. Neste estudo, optou-se por avaliar os pacientes atópicos fora das crises alérgicas, com a finalidade de se conhecer as expressões das citocinas neste período. MATERIAL E MÉTODO: Realizou-se um estudo transversal e prospectivo, selecionando-se 30 pacientes, sendo 13 pacientes portadores de rinite alérgica paucissintomáticos e 17 pacientes não-atópicos. Os grupos foram selecionados através da história, do exame clínico otorrinolaringológico e do teste alérgico cutâneo - Prick Test. O perfil das citocinas foi pesquisado nos fragmentos de mucosa nasal, através da RT-PCR semiquantitativa, escolhida por apresentar boa reprodutibilidade e especificidade, utilizando-se como referência o gene da Beta-actina. RESULTADOS: Os valores de IL-5, IL-8, IFN-gama mantiveram-se homogêneos em relação ao grupo controle. A IL-4 apresentou diferença com significância estatística. CONCLUSÃO: Os pacientes alérgicos paucissintomáticos apresentaram normalização da expressão das citocinas na mucosa nasal à exceção de IL-4.Allergic rhinitis is an inflammatory reaction of the nasal mucosa, in consequence of an IgE mediated hypersensitive reaction to inhaling allergens, involving different mediators and cytokine cells. AIM: The purpose of this study was to evaluate the transcriptions for IL-4, IL-5, IL-8 and IFN-gama, particularly important in the nasal allergy process, especially IL-4 and IL-5. For this study we decided to evaluate atopic patients who were free from allergic crises, with the purpose of

  5. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine

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    Wang XY

    2016-04-01

    Full Text Available Xue Yan Wang,1 Margaret Lim-Jurado,2 Narayanan Prepageran,3 Pongsakorn Tantilipikorn,4 De Yun Wang5 1Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2St Luke’s Medical Center, Quezon City, Manila, Philippines; 3Department of Otorhinolaryngology, Head & Neck Surgery, University Malaya Faculty of Medicine, Kuala Lumpur, Malaysia; 4Rhinology and Allergy Division, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 5Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Abstract: Allergic rhinitis and urticaria are common allergic diseases that may have a major negative impact on patients’ quality of life. Bilastine, a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. This agent does not interact with the cytochrome P450 system and does not undergo significant metabolism in humans, suggesting that it has very low potential for drug–drug interactions, and does not require dose adjustment in renal impairment. As bilastine is not metabolized and is excreted largely unchanged, hepatic impairment is not expected to increase systemic exposure above the drug’s safety margin. Bilastine has demonstrated similar efficacy to cetirizine and desloratadine in patients with seasonal allergic rhinitis and, in a Vienna Chamber study, a potentially longer duration of action than fexofenadine in patients with asymptomatic seasonal allergic rhinitis. It has also shown significant efficacy (similar to that of cetirizine and safety in the long-term treatment of perennial allergic rhinitis. Bilastine showed similar efficacy to levocetirizine in patients with chronic spontaneous urticaria and can be safely used at doses of up to fourfold higher than standard dosage (80 mg once daily. The

  6. Common aeroallergens in patients with asthma and allergic rhinitis living in southwestern part of iran: based on skin prick test reactivity.

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    Shokrollah Farrokhi

    2015-04-01

    Full Text Available Aeroallergens continue to have a key role in the pathogenesis of asthma and allergic diseases and have recently received increased attention in medical research throughout the world. The prevalence of aeroallergens vary in different regions, depending on the type of climate. The aim of the present study was to determine prevalence of the sensitivity to aeroallergens among patients with asthma and allergic rhinitis (AR, based on skin prick test (SPT reactivity in the province of Bushehr, Iran. In this cross-sectional study, 743 patients were enrolled. The participants had asthma and AR and reacted to at least one allergen with SPT. Skin prick test with standard extracts including house dust mites (HDMs, animal dander, molds and pollens were performed on patients according to the herbal geography of the area. The male to female ratio and mean age of the patients were 1.03 and 27.6± 15.4 year, respectively. Out of 567 patients with AR, the common aeroallergens were HDMs (88.5%, molds (82.9%, animal dander (79.5%, weeds (77.6%, trees (75.5% and grass pollen (71.5%. Moreover, among 176 patients with asthma, the prevalence of aeroallergens were HDMs (90.5 %, molds (80.7%, animal dander (77.5%, weeds (73.3%, trees (73.3% and grass pollen (67.9%. The sensitivity to animal dander, Chenopodium album and Russian thistle pollens were significantly associated with the severity of AR. Moreover, sensitivity to animal dander such as cat and feather of birds, cockroach, Bermuda grass and Chenopodium album pollens were significantly associated with the severity of asthma. The results of this study revealed that HDM was the most common sensitizing aeroallergen in patients with asthma and AR. Molds and animal dander as indoor allergens were also common aeroallergens. We suggest that the hot weather and ambient humidity in the region may be the main cause of the change in the pattern of SPT reactivity.

  7. Effect of Treatment with Intranasal Corticosteroid and Oral Antihistamine on Cytokine Profiles of Peripheral Blood Mononuclear Cells of Patients with Allergic Rhinitis Sensitive to Chenopodium album

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    Shokrollah Farrokhi

    2010-12-01

    Full Text Available Patients with allergic rhinitis (AR show increased production of the Th2-related cytokines. Almost always, intranasal corticosteroid (INC and antihistamine are used as routine therapy of AR. This study was performed to determine the in vitro secretion of cytokines profiles of PBMCs in patients with AR sensitive to Chenopodium album (Ch.a pollens before and after treatment with INC (Fluticasone propionate and oral antihistamine (Loratadine. PBMCs of 20 patients with AR, were tested in vitro for cytokine production. These cells were stimulated with natural or recombinant Ch.a. The levels of IL-4, IL-13 and IFN-, were measured in supernatants of cultured cell 96h after stimulation using ELISA. The PBMCs of 20 normal individuals were also similarly treared for comparison of results. The production of IL-4 by the patients' cells stimulated with either Ch.a or rCh.a was significantly higher than normal levels before therapy (p=0.04 and p=0.02, respectively. After therapy, a significant decrease in production of IL-4 and a significant increase in production of IL-10 were found in PBMCs stimulated with natural Ch.a, in comparison to the results before stimulation (p=0.03 for IL-4; p=0.04 for IL-10. Similarly, these results were seen in the production of IL-4 and IL-10 stimulated with rCh.a allergen after therapy in comparison to the results before stimulation (p=0.01 for IL-4; p=0.03 for IL-10. This study suggests INC (Fluticasone propionate and oral antihistamine (Loratadine have the capacity to inhibit the production of IL-4 and shift Th2/Th1 responses, probably due to increase the level of immunoregulatory IL-10. Therefore, it could be concluded that therapy with INC and antihistamine has pharmacologic and immunologic therapeutic effects on AR patients.

  8. In vivo and in vitro studies of Th17 response to specific immunotherapy in house dust mite-induced allergic rhinitis patients.

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    Chun Wei Li

    Full Text Available T helper (Th17 cells have been implicated in the development of allergic rhinitis (AR, but their response to specific immunotherapy (SIT remains unclear. We investigated the impact of SIT on Th17 response and Th1/Th2 changes in AR patients. Blood samples from AR patients (n = 20 who were monosensitized to house dust mite (HDM were collected before the initiation of SIT (SIT-untreated and after the end of 2-year SIT (SIT-treated treatment. Twenty healthy volunteers were recruited as controls. In vitro HDM stimulation in peripheral blood mononuclear cells (PBMCs was also performed. Expression levels of Th17 associated genes were determined in both PBMCs and plasma by PCR and ELISA, while Th17/Th1/Th2/IL10 producing cell proportions were evaluated in PBMCs by flow cytometry. The SIT effect was evaluated by assessing clinical symptoms. mRNA levels of Th17 specific genes (IL17 and RORC were increased in SIT-untreated AR versus controls, and decreased following SIT treatment. SIT can change the production of Th17 associated genes (reduction of IL17, IL6, and IL23, but increase of IL27 in plasma from AR patients. Th2/Th1 ratio and proportions of Th17 cells were suppressed while IL10 producing CD4+ T cells were elevated after SIT. In vitro HDM challenge presents concordant patterns with in vivo findings: 1 increase of Th2 and Th17 response in AR patients; 2 suppression of IL10 producing CD4+ T cells in SIT-untreated AR but elevation in SIT-treated AR patients. Most importantly, a positive correlation between IL17 mRNA/protein levels and clinical symptom scores was observed. SIT significantly inhibits Th17 mediated inflammation in AR and IL17 may be a useful biomarker for both AR severity and SIT therapeutic effect.Australian New Zealand Clinical Trials Registry (ANZCTR ACTRN12613000445774.

  9. The efficacy of Rhinos® SR on nasal resistance and nasal symptoms in patients with perennial allergic rhinitis : a randomized, double-blind, placebo-controlled study

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    Arini Setiawati

    2008-06-01

    Full Text Available Rhinos® SR is a fixed combination of 5 mg loratadine and 60 mg pseudoephedrine immediate release and 60 mg pseudoephedrine sustained release. The present study was aimed to assess the efficacy of Rhinos® SR on nasal airway resistance (NAR objectively using rhinomanometer and on nasal symptoms in patients with perennial allergic rhinitis (PAR in a tropical country. This was a randomized, double-blind, parallel group study in 59 PAR patients who visited the ENT clinic at Dr. Soetomo General Hospital, Surabaya. Outpatients of both gender, having moderate to severe PAR for a minimal of 2 years, aged 12 years or older, with a total nasal symptom score (TNSS > 6 and a nasal congestion score > 2, received Rhinos® SR or placebo twice daily for 7 days. The primary efficacy parameter was the decrease in the NAR values (measured by rhinomanometer on Day 1 of Rhinos® SR from those of placebo. The NAR values were calculated as the area under the curve (AUC of NAR versus time. The secondary efficacy parameters were the percentage reduction of the clinical symptoms (nasal and nonnasal evaluated by both the patient and the physician after 1 week use of Rhinos® SR or placebo. From 59 eligible patients, all completed this 1-week trial. For NAR values, after the baseline were considered as 100%, the AUC0-10 h were not significantly different between Rhinos® SR and placebo. However, as the pseudoephedrine reached its peak concentration, i.e. 2 hrs for the immediate release and 6 hrs for the sustained release, then AUC0-2 h and AUC0-6 h of Rhinos® SR were significantly lower compared to those of placebo. Total nasal symptom score (TNSS evaluated by the patient (sum of the last 3 mornings for Rhinos® SR decreased 33.0% from baseline (p < 0.001, for placebo decreased 21.9% from baseline (p = 0.002, but the decrease by Rhinos® SR was not significantly different from the decrease by placebo. TNSS evaluated by the physician, nasal congestion score (NCS and total

  10. Trichuris suis ova therapy for allergic rhinitis

    DEFF Research Database (Denmark)

    Bager, Peter; Arnved, John; Rønborg, Steen;

    2010-01-01

    Parasitic helminth infections can protect against allergic airway inflammation in experimental models and have been associated with a reduced risk of atopy and a reduced course of asthma in some observational studies. Although no clinical evidence exists to support the use of helminth therapy...

  11. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis)

    DEFF Research Database (Denmark)

    Bousquet, J; Schunemann, H J; Fonseca, J;

    2015-01-01

    -based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS......) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards....

  12. Responses of Six-Weeks Aquatic Exercise on the Autonomic Nervous System, Peak Nasal Inspiratory Flow and Lung Functions in Young Adults with Allergic Rhinitis.

    Science.gov (United States)

    Janyacharoen, Taweesak; Kunbootsri, Narupon; Arayawichanon, Preeda; Chainansamit, Seksun; Sawanyawisuth, Kittisak

    2015-06-01

    Allergic rhinitis is a chronic respiratory disease. Sympathetic hypofunction is identified in all of the allergic rhinitis patients. Moreover, allergic rhinitis is associated with decreased peak nasal inspiratory flow (PNIF) and impaired lung functions. The aim of this study was to investigate effects of six-week of aquatic exercise on the autonomic nervous system function, PNIF and lung functions in allergic rhinitis patients. Twenty-six allergic rhinitis patients, 12 males and 14 females were recruited in this study. Subjects were diagnosed by a physician based on history, physical examination, and positive reaction to a skin prick test. Subjects were randomly assigned to two groups. The control allergic rhinitis group received education and maintained normal life. The aquatic group performed aquatic exercise for 30 minutes a day, three days a week for six weeks. Heart rate variability, PNIF and lung functions were measured at the beginning, after three weeks and six weeks. There were statistically significant increased low frequency normal units (LF n.u.), PNIF and showed decreased high frequency normal units (HF n.u.) at six weeks after aquatic exercise compared with the control group. Six weeks of aquatic exercise could increase sympathetic activity and PNIF in allergic rhinitis patients.

  13. A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification

    Science.gov (United States)

    Arebro, Julia; Ekstedt, Sandra; Hjalmarsson, Eric; Winqvist, Ola; Kumlien Georén, Susanna; Cardell, Lars-Olaf

    2017-01-01

    A re-examination of former concepts is required to meet today’s medical challenges in allergic rhinitis. Previously, neutrophils have been treated as a relatively homogenous cell population found in the nose both when the patient is suffering at the height of the allergic season as well as when the patient report no symptoms. However, new data indicates that neutrophils can be divided into different subsets with diverse roles in inflammation. We showed increased levels of neutrophils in peripheral blood, nasal biopsies and nasal lavage fluid (NAL) from allergic patients during the pollen season compared to healthy controls. A closer examination revealed that the activated subset of neutrophils, CD16high CD62Ldim, outweighed the normal form CD16high CD62Lhigh in nasal tissue among these patients. This skewed distribution was not seen in controls. The normal subset prevailed in peripheral blood from patients as well as controls, whereas CD16high CD62Ldim and CD16dim CD62Ldim subsets, the latter considered “end state” neutrophils before apoptosis, were elevated in NAL. Functional in vitro experiments revealed that activated neutrophils exhibit a T cell priming capacity and an ability to enhance eosinophil migration. Activated neutrophils may thus contribute to allergic inflammation seen in allergic rhinitis by priming T cells and attracting eosinophils. PMID:28272395

  14. Efficacy of chlorophyll c2 for seasonal allergic rhinitis: single-center double-blind randomized control trial.

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    Fujiwara, Takashi; Nishida, Naoya; Nota, Jumpei; Kitani, Takashi; Aoishi, Kunihide; Takahashi, Hirotaka; Sugahara, Takuya; Hato, Naohito

    2016-12-01

    Chlorophyll c2 extracted from Sargassum horneri improved allergic symptoms in an animal model of allergic rhinitis. In the present study, we explored the efficacy of chlorophyll c2 in patients with seasonal allergic rhinitis. This was a single-center, randomized, double-blind placebo-controlled trial. Sixty-six patients aged 20-43 years, each with a 2-year history of seasonal allergic rhinitis, were randomly assigned to receive either a single daily dose (0.7 mg) of chlorophyll c2 or placebo for 12 weeks. The use of medications including H1-antihistamines and topical nasal steroids was recorded by rescue medication scores (RMSs) noted after 4, 8, and 12 weeks of treatment. Disease-specific quality of life was measured using the Japan Rhinitis Quality of Life Questionnaire (JRQLQ) both before and after 4, 8, and 12 weeks of treatment. The RMS at 8 weeks was significantly better in the chlorophyll c2 than the placebo group (mean RMS difference = -3.09; 95 % confidence interval = -5.96 to -0.22); the mean RMS at 4 weeks was only slightly better in the chlorophyll c2 group. The JRQLQ scores did not differ significantly between the two groups. Chlorophyll c2 would have a potential to be an alternative treatment for allergic rhinitis.

  15. An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients.

    Science.gov (United States)

    Wei, Ping; Hu, Guo-Hua; Kang, Hou-Yong; Yao, Hong-Bing; Kou, Wei; Liu, Hong; Zhang, Cheng; Hong, Su-Ling

    2014-05-01

    A predominant Th17 population is a marker of allergic rhinitis (AR). The aryl hydrocarbon receptor (AhR) exhibits strong immunomodulation potential via regulation of the differentiation of T lymphocytes and dendritic cells (DCs) after activation by its ligand, such as 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). The aim of this study was to analyze the effect of AhR on Th17 differentiation by investigating the action of ITE on DCs and CD4(+) T cells from patients with AR. In all, 26 AR patients and 12 healthy controls were included in this study. The expression of interleukin (IL)-1β, IL-6, IL-10, and IL-17 in the culture supernatant and the presence of Th17 cells in CD4(+) T cells and DC-CD4(+) T-cell co-culture system were measured before and after treatment with ITE. We show that ITE significantly induced cell secretion of IL-10 and inhibited IL-1β and IL-6 production in DCs, and promoted IL-10 production and suppressed IL-17 expression in CD4(+) T cells in vitro. It also suppressed the expansion of Th17 cells in vitro. Our work demonstrates that ITE acts on DCs and CD4(+) T cells to inhibit the Th17 response that suppresses AR; the AhR-DC-Th17 axis may be an important pathway in the treatment of AR. ITE, a nontoxic AhR ligand, attenuated the Th17 response; thus, it appears to be a promising therapeutic candidate for suppressing the inflammatory responses associated with AR.

  16. EFFECT OF SHADBINDU GHRITA NASYA AND HARIDRAKHANDA IN PRATISHYAYA: ALLERGIC RHINITIS

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    Sandhya Rani. D

    2013-10-01

    Full Text Available Among Nasagath Rogas, most of the acharyas described pratishyaya with its complications which proves the seriousness of the disease. Acharya susrutha clearly mentioned in Uttar tantra that Pratishyaya is the disease condition in which Vata and Kapha dusti was observed. Allergic Rhinitis is a disease characterized by sudden and frequent attacks of sneezing, profuse watery nasal discharge associated with nasal obstruction which is intermittent, watering of the eyes, heaviness of head, respiratory distress and anosmia. The present study aims to comparatively evaluate the clinical efficacy of shadbindu gritha nasya with haridra khanda internally in pratishayaya. The principle objective of the study is to find a most effective, economical and simple treatment for pratishayaya. Here 45 patients of pratishyaya- Allergic Rhinitis were treated in 3 groups. 15 patient of group A treated with Shadbindu gritha Nasya. 15 patient of group B treated with Haridrakhanda orally. 15 patient of group C treated with both Shadbindu gritha nasya and haridrakhanda as a combined therapy. After the enrollment of the patients in the study, vital signs and symptoms of Pratishyaya-Allergic rhinitis such as Nasa srava, Khavatu, Nasa avarodha, gala talu shuskata, were studied before and after the treatment. The results of the study indicated that the group c bestowed with highly significant relief in almost all the signs and symptoms in comparison to group A and group B.

  17. Critical appraisal of Timothy grass pollen extract GRAZAX in the management of allergic rhinitis.

    Science.gov (United States)

    Scaparrotta, Alessandra; Attanasi, Marina; Petrosino, Marianna I; Di Filippo, Paola; Di Pillo, Sabrina; Chiarelli, Francesco

    2015-01-01

    Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP) allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense) pollen and ~15 μg major allergen P. pratense (rPhl p 5), may be the future of allergen-specific immunotherapy (IT) for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT.

  18. Mouse Model of Cat Allergic Rhinitis and Intranasal Liposome-Adjuvanted Refined Fel d 1 Vaccine.

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    Natt Tasaniyananda

    Full Text Available Cats (Felis domesticus are rich source of airborne allergens that prevailed in the environment and sensitized a number of people to allergy. In this study, a mouse model of allergic rhinitis caused by the cat allergens was developed for the first time and the model was used for testing therapeutic efficacy of a novel intranasal liposome-entrapped vaccines made of native Fel d 1 (major cat allergen in comparison with the vaccine made of crude cat hair extract (cCE. BALB/c mice were sensitized with cCE mixed with alum intraperitoneally and intranasally. The allergic mice were treated with eight doses of either liposome (L-entrapped native Fel d 1 (L-nFD1, L-cCE, or placebo on every alternate day. Vaccine efficacy evaluation was performed one day after provoking the treated mice with aerosolic cCE. All allergenized mice developed histological features of allergic rhinitis with rises of serum specific-IgE and Th2 cytokine gene expression. Serum IgE and intranasal mucus production of allergic mice reduced significantly after vaccination in comparison with the placebo mice. The vaccines also caused a shift of the Th2 response (reduction of Th2 cytokine expressions towards the non-pathogenic responses: Th1 (down-regulation of the Th1 suppressive cytokine gene, IL-35 and Treg (up-regulation of IL-10 and TGF-β. In conclusions, a mouse model of allergic rhinitis to cat allergens was successfully developed. The intranasal, liposome-adjuvanted vaccines, especially the refined single allergen formulation, assuaged the allergic manifestations in the modeled mice. The prototype vaccine is worthwhile testing further for clinical use in the pet allergic patients.

  19. Mouse Model of Cat Allergic Rhinitis and Intranasal Liposome-Adjuvanted Refined Fel d 1 Vaccine

    Science.gov (United States)

    Tasaniyananda, Natt; Chaisri, Urai; Tungtrongchitr, Anchalee; Chaicumpa, Wanpen; Sookrung, Nitat

    2016-01-01

    Cats (Felis domesticus) are rich source of airborne allergens that prevailed in the environment and sensitized a number of people to allergy. In this study, a mouse model of allergic rhinitis caused by the cat allergens was developed for the first time and the model was used for testing therapeutic efficacy of a novel intranasal liposome-entrapped vaccines made of native Fel d 1 (major cat allergen) in comparison with the vaccine made of crude cat hair extract (cCE). BALB/c mice were sensitized with cCE mixed with alum intraperitoneally and intranasally. The allergic mice were treated with eight doses of either liposome (L)-entrapped native Fel d 1 (L-nFD1), L-cCE), or placebo on every alternate day. Vaccine efficacy evaluation was performed one day after provoking the treated mice with aerosolic cCE. All allergenized mice developed histological features of allergic rhinitis with rises of serum specific-IgE and Th2 cytokine gene expression. Serum IgE and intranasal mucus production of allergic mice reduced significantly after vaccination in comparison with the placebo mice. The vaccines also caused a shift of the Th2 response (reduction of Th2 cytokine expressions) towards the non-pathogenic responses: Th1 (down-regulation of the Th1 suppressive cytokine gene, IL-35) and Treg (up-regulation of IL-10 and TGF-β). In conclusions, a mouse model of allergic rhinitis to cat allergens was successfully developed. The intranasal, liposome-adjuvanted vaccines, especially the refined single allergen formulation, assuaged the allergic manifestations in the modeled mice. The prototype vaccine is worthwhile testing further for clinical use in the pet allergic patients. PMID:26954254

  20. 南阳市慢性过敏性鼻炎患者过敏原检测结果分析%Analysis of Allergen Detection Results in Patients With Chronic Allergic Rhinitis in Nanyang City

    Institute of Scientific and Technical Information of China (English)

    宋彬

    2015-01-01

    Objective To understand the types and distribution of allergens in patients with chronic allergic rhinitis in nanyang, and to provide reliable evidence for the prevention and treatment of this disease.Methods ELISA method was used for the determination of serum total IgE and specific IgE in patients with chronic allergic rhinitis, and the comparative analysis was carried out.Results Patients with chronic allergic rhinitis in total IgE positive rate of 100%, the 2 cases of specific allergen test negative, specific allergen detection results for dermatophagoides pteronyssinus 113 cases of the positive (37.7%), house dust was positive in 90 cases (30.0%), trees (oak, elm, sycamore, willow, cottonwood yang) was positive in 54 cases (18.0%). Conclusion Nanyang city cause chronic allergic rhinitis allergic principle mainly in household dust mites, house dust, trees (oak, elm, sycamore, willow, cottonwood yang).%目的 了解南阳市慢性过敏性鼻炎患者过敏原的种类及分布,为本病预防和治疗提供可靠依据.方法 采用ELISA法对慢性过敏性鼻炎患者的血清总IgE和特异性IgE进行半定量测定,并进行对比分析.结果 慢性过敏性鼻炎患者中总IgE阳性率100%,其中2例特异性过敏原检测阴性,特异性过敏原检测结果 为:户尘螨阳性113例(37.7%),屋尘阳性90例(30.0%),树木(栎树、榆树、梧桐、柳树、三角叶杨)阳性54例(18.0%).结论 南阳市引起慢性过敏性鼻炎的过敏原主要是户尘螨,屋尘,树木(栎树、榆树、梧桐、柳树、三角叶杨).

  1. Allergic Rhinitis and Associated Comorbidities: Prevalence in Oman with Knowledge Gaps in Literature

    Directory of Open Access Journals (Sweden)

    Rashid Al-Abri

    2014-11-01

    Full Text Available Objectives: Allergic rhinitis (AR is a global health problem and its impact on health related quality of life for patients is substantial, and the economic impact often underestimated. The prevalence of allergic rhinitis in Oman is unknown. This study aimed to estimate the prevalence of AR and associated co-morbidities among adults in Oman. Its secondary objective was to identify knowledge gaps in the literature with the aim of directing future research. Methods: A prospective, cross-sectional study of patients who presented to the outpatient otolaryngology clinic at Sultan Qaboos University Hospital with nasal symptoms between June 2010 and June 2011 was conducted. Results: A total of 887 patients were seen with nasal complaints. Among them 127 patients were diagnosed with non-infective rhinitis, the mean age of presentation was 27 years. AR was noted in 48% of patients, and non-allergic rhinitis in 52%. The prevalence of AR was 7%, with females being more affected than males, and age ranging from 18 to 51 years. Prevalence of perennial AR was 84% compared to seasonal AR which was 16%. The most common perennial antigens were house dust mites (80% followed by cockroaches (67%. All patients diagnosed with seasonal AR were found to be sensitive to Russian thistle. The prevalence of chronic rhinosinusitis in patients with AR was 34%. Conclusion: The prevalence of AR in the adult population presenting with nasal symptoms was found to be 7%, with associated chronic rhinosinusitis present in a third of these patients. However, there appears to be substantial knowledge gaps regarding the association of other comorbidities, like otitis media, bronchitis and bronchial asthma, the long-term outcomes of medical management, and indication of surgical intervention in patients with AR. Future research in AR among Omani patients should aim to address these issues.

  2. 云南保山地区变应性鼻炎花粉变应原调查分析%Investigation on Pollen Allergen in Patients with Allergic Rhinitis in Baoshan, Yunnan

    Institute of Scientific and Technical Information of China (English)

    杨国宁; 李明华; 马亚

    2016-01-01

    Objective:To investigate the distribution of pollen allergens in patients with allergic rhinitis(AR)in Baoshan, Yunnan, and to offer basis for the diagnosis, prevention and treatment. Methods:980 allergic rhinitis were examined by skin prick test(SPT) with 15 kinds of pollen antigen extract of allergic rhinitis. Results: Among 980 cases, 269 cases(27.4%)were detected with one antigen, 460 cases(46.9%)were detected with two or more antigens. The main common pollen allergens in patients with allergic rhinitis in Baoshan were 348 cases of Gramineae (35.5%), 310 cases of aestivo-autumnal (31.6%), 251 cases of Chinese ash (25.6%), 2 cases of sakura(0.2%)which is the least one. Positive rate of pollen allergens were different between youngsters group and middle-aged group. Conclusion:Gramineae, stivo-autumnal and Chinese ash were the main pollen allergens of allergic rhinitis in Baoshan. Most patients with allergic rhinitis were allergic to two or more kinds of pollen allergens. Skin prick test(SPT)is helpful for the discovery of the allergens so as to provide important basis of desensitization therapy.%目的:了解保山地区变应性鼻炎患者花粉变应原分布情况,为变应性鼻炎的诊断、预防和治疗提供依据。方法:采用15种花粉变应原提取液对980例变应性鼻炎的患者进行皮肤皮内试验。结果:980例患者中,检出1种变应原阳性者269例(27.4%),检出2种及2种以上变应原阳性者460例(46.9%),主要的花粉变应原是禾本科348例(35.5%)、夏秋310(31.6%)、白蜡树251(25.6%),最少的是樱花,2例(0.2%)。年龄不同,变应原阳性率也不同。结论:禾本科、夏秋、白蜡树是保山地区变应性鼻炎最常见的花粉变应原。大部分患者对2种及2种以上花粉过敏。变应原点刺试验有助于发现变应原,并为脱敏治疗提供依据。

  3. Control of Allergic Rhinitis and Asthma Test (CARAT) : dissemination and applications in primary care

    NARCIS (Netherlands)

    Azevedo, Pedro; Correia-de-Sousa, Jaime; Bousquet, Jean; Bugalho-Almeida, Antonio; Del Giacco, Stefano R.; Demoly, Pascal; Haahtela, Tari; Jacinto, Tiago; Garcia-Larsen, Vanessa; van der Molen, Thys; Morais-Almeida, Mario; Nogueira-Silva, Luis; Pereira, Ana M.; Roman-Rodrigues, Miguel; Silva, Barbara G.; Tsiligianni, Ioanna G.; Yaman, Hakan; Yawn, Barbara; Fonseca, Joao A.

    2013-01-01

    Asthma frequently occurs in association with allergic rhinitis and a combined management approach has been suggested. The Control of Allergic Rhinitis and Asthma Test (CARAT) is the first questionnaire to assess control of both diseases concurrently. However, to have an impact on healthcare it needs

  4. Efficacy of desloratadine in persistent allergic rhinitis - a GA²LEN study

    DEFF Research Database (Denmark)

    Bousquet, Jean; Bachert, Claus; Canonica, Giorgio W;

    2010-01-01

    The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent or persistent) rather than on the time of allergen exposure (seasonal or perennial). There had been no placebo-controlled, randomized, c...

  5. The pathogenesis of allergic rhinitis : cellular aspects with special emphasis on Langerhans cells

    NARCIS (Netherlands)

    W.J. Fokkens (Wytske)

    1991-01-01

    textabstractPresent ideas concerning the pathogenesis of allergic rhinitis are largely deduced from systemic investigations and extrapolated from studies in the skin and the lung. Studies on allergic rhinitis generally comprise clinical aspects and/or biochemical, humoral and cellular features of th

  6. An overview of the novel H1-antihistamine bilastine in allergic rhinitis and urticaria.

    Science.gov (United States)

    Jáuregui, Ignacio; García-Lirio, Eduardo; Soriano, Ana María; Gamboa, Pedro M; Antépara, Ignacio

    2012-01-01

    Currently available second-generation H1-antihistamines include a wide group of drugs with a better therapeutic index (or risk-benefit ratio) than the classic antihistamines, although their properties and safety profiles may differ. Bilastine is a newly registered H1-antihistamine for the oral treatment of allergic rhinitis and urticaria, with established antihistaminic and antiallergic properties. Clinical studies in allergic rhinitis and chronic urticaria show that once-daily treatment with bilastine 20 mg is effective in managing symptoms and improving patient's quality of life, with at least comparable efficacy to other nonsedative H1-antihistamines. As far as studies in healthy volunteers, clinical assays and clinical experience can establish, bilastine's safety profile is satisfactory, since it lacks anticholinergic effects, does not impair psychomotor performance or actual driving, and appears to be entirely free from cardiovascular effects.

  7. Evaluation of total IgE, CRP and blood count parameters in children with asthma and allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Feti Tülübaş

    2013-03-01

    Full Text Available Objective: This study aimed to research retrospectivelywhether asthma and allergic rhinitis are related to totalIgE, C-reactive protein (CRP and complete blood countparameters.Materials and methods: Files of 443 children who appliedto pediatric outpatient clinics of our hospital,aged2-18 were retrospectively investigated. Patients weregrouped into three as asthma (n=179, allergic rhinitis (n=171 and control group (n= 93. Patients’ ages, genders,total IgE, CRP and hemogram values were recorded.Results: While eosinophil count, MCHC and total IgElevels were significantly higher in asthma group, MCVlevels were significantly lower. Lymphocyte count, CRPand total IgE levels were significantly higher in allergicrhinitis group compared with control group whereas neutrophilcount were significantly lower and eosinophil countdid not change significantly. Total IgE levels were higherin asthma and allergic rhinitis compared with controls.However, CRP levels were higher only in allergic rhinitisgroup. MCV levels were significantly lower in asthmagroup compared with controls. MCHC levels were significantlyhigher in asthma group compared with allergicrhinitis and control groups. Neutrophil count decreasedwhile lymphocyte count increased significantly. Eosinophilcount significantly increased compared with controlgroup whereas a significant difference was not observedbetween allergic rhinitis and controls.Conclusions: Our findings suggest factors effective inasthma pathogenesis might be effective also in erythrocytemorphology. There are remarkable changes in bloodeosinophil levels in asthma and in neuthrophil and lymphocytelevels in allergic rhinitis. Serum total IgE level increasesin asthma group whereas it decreases in allergicrhinitis group.Key words: Asthma, allergic rhinitis, total IgE, CRP, MCV

  8. Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

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    Scaparrotta A

    2015-11-01

    Full Text Available Alessandra Scaparrotta, Marina Attanasi, Marianna I Petrosino, Paola Di Filippo, Sabrina Di Pillo, Francesco Chiarelli Department of Pediatrics, University of Chieti, Chieti, Italy Abstract: Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense pollen and ~15 µg major allergen P. pratense (rPhl p 5, may be the future of allergen-specific immunotherapy (IT for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT. Keywords: Timothy grass pollen extract, allergic rhinitis, Grazax, efficacy, safety, compliance

  9. Impact of self-reported symptoms of allergic rhinitis and asthma on sleep disordered breathing and sleep disturbances in the elderly with polysomnography study

    Science.gov (United States)

    Kim, Sae-Hoon; Won, Ha-Kyeong; Moon, Sung-Do; Kim, Byung-Keun; Chang, Yoon-Seok; Kim, Ki-Woong; Yoon, In-Young

    2017-01-01

    Background Sleep disordered breathing (SDB) and sleep disturbances have been reported to be associated with allergic rhinitis and asthma. However, population-based studies of this issue in the elderly are rare. Objective To investigate the impact of self-reported rhinitis and asthma on sleep apnea and sleep quality using polysomnography in an elderly Korean population. Methods A total of 348 elderly subjects who underwent one-night polysomnography study among a randomly selected sample were enrolled. Study subjects underwent anthropometric and clinical evaluations. Simultaneously, the prevalence and co-morbid status of asthma and allergic rhinitis, and subjective sleep quality were evaluated using a self-reported questionnaire. Results Ever-diagnosis of allergic rhinitis was significantly more prevalent in subjects with SDB compared with those without SDB. Subjects with an ever-diagnosis of allergic rhinitis showed a higher O2 desaturation index and mean apnea duration. Indices regarding sleep efficiency were affected in subjects with a recent treatment of allergic rhinitis or asthma. Waking after sleep onset was longer and sleep efficiency was lower in subjects who had received allergic rhinitis treatment within the past 12 months. Subjects who had received asthma treatment within the past 12 months showed significantly lower sleep efficiency than others. Conclusion Our study indicates that a history of allergic rhinitis is associated with increased risk of SDB in the elderly. Sleep disturbance and impaired sleep efficiency were found in the subjects who had received recent treatment of allergic rhinitis or asthma. Physicians should be aware of the high risk of sleep disorders in older patients with respiratory allergic diseases. PMID:28245272

  10. Treating allergic rhinitis by sublingual immunotherapy: a review

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    Cristoforo Incorvaia

    2012-06-01

    Full Text Available OBJECTIVE: Allergic rhinitis (AR is a disease with high and increasing prevalence. The management of AR includes allergen avoidance, anti-allergic drugs, and allergen specific immunotherapy (AIT, but only the latter works on the causes of allergy and, due to its mechanisms of action, modifies the natural history of the disease. Sublingual immunotherapy (SLIT was proposed in the 1990s as an option to traditional, subcutaneous immunotherapy. MATERIAL AND METHODS: We reviewed all the available controlled trials on the efficacy and safety of SLIT. RESULTS AND CONCLUSION: Thus far, more than 60 trials, globally evaluated in 6 meta-analyses, showed that SLIT is an effective and safe treatment for AR. However, it must be noted that to expect clinical efficacy in the current practice SLIT has to be performed following the indications from controlled trials, that is, sufficiently high doses to be regularly administered for at least 3 consecutive years.

  11. Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4

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    Lacoeuille Yannick

    2011-02-01

    Full Text Available Abstract Background Th2 cell activation and T regulatory cell (Treg deficiency are key features of allergy. This applies for asthma and rhinitis. However with a same atopic background, some patients will develop rhinitis and asthma, whereas others will display rhinitis only. Co-receptors are pivotal in determining the type of T cell activation, but their role in allergic asthma and rhinitis has not been explored. Our objective was to assess whether allergen-induced T cell activation differs from allergic rhinitis to allergic rhinitis with asthma, and explore the role of ICOS, CD28 and CTLA-4. Methods T cell co-receptor and cytokine expressions were assessed by flow cytometry in PBMC from 18 house dust mite (HDM allergic rhinitics (R, 18 HDM allergic rhinitics and asthmatics (AR, 13 non allergic asthmatics (A and 20 controls, with or without anti-co-receptors antibodies. Results In asthmatics (A+AR, a constitutive decrease of CTLA-4+ and of CD4+CD25+Foxp3+ cells was found, with an increase of IFN-γ+ cells. In allergic subjects (R + AR, allergen stimulation induced CD28 together with IL-4 and IL-13, and decreased the proportion of CTLA-4+, IL-10+ and CD4+CD25+Foxp3+ cells. Anti-ICOS and anti-CD28 antibodies blocked allergen-induced IL-4 and IL-13. IL-13 production also involved CTLA-4. Conclusions T cell activation differs between allergic rhinitis and asthma. In asthma, a constitutive, co-receptor independent, Th1 activation and Treg deficiency is found. In allergic rhinitis, an allergen-induced Treg cell deficiency is seen, as well as an ICOS-, CD28- and CTLA-4-dependent Th2 activation. Allergic asthmatics display both characteristics.

  12. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

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    Greiff Lennart

    2012-06-01

    Full Text Available Abstract Background Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective To evaluate the efficacy and safety of intranasal AZD8848. Methods In a placebo-controlled single ascending dose study, AZD8848 (0.3-600 μg was given intranasally to 48 healthy subjects and 12 patients with allergic rhinitis (NCT00688779. In a placebo-controlled repeat challenge/treatment study, AZD8848 (30 and 60 μg was given once weekly for five weeks to 74 patients with allergic rhinitis out of season: starting 24 hours after the final dose, daily allergen challenges were given for seven days (NCT00770003. Safety, tolerability, pharmacokinetics, and biomarkers were monitored. During the allergen challenge series, nasal symptoms and lavage fluid levels of tryptase and α2-macroglobulin, reflecting mast cell activity and plasma exudation, were monitored. Results AZD8848 produced reversible blood lymphocyte reductions and dose-dependent flu-like symptoms: 30–100 μg produced consistent yet tolerable effects. Plasma interleukin-1 receptor antagonist was elevated after administration of AZD8848, reflecting interferon production secondary to TLR7 stimulation. At repeat challenge/treatment, AZD8848 reduced nasal symptoms recorded ten minutes after allergen challenge up to eight days after the final dose. Tryptase and α2-macroglobulin were also reduced by AZD8848. Conclusions Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis. Trial registration NCT00688779 and NCT00770003 as indicated above.

  13. Responses of Six-Weeks Aquatic Exercise on the Autonomic Nervous System, Peak Nasal Inspiratory Flow and Lung Functions in Young Adults with Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Taweesak Janyacharoen

    2015-10-01

    Full Text Available Allergic rhinitis is a chronic respiratory disease. Sympathetic hypofunction is identified in all of the allergic rhinitis patients. Moreover, allergic rhinitis is associated with decreased peak nasal inspiratory flow (PNIF and impaired lung functions. The aim of this study was to investigate effects of six-week of aquatic exercise on the autonomic nervous system function, PNIF and lung functions in allergic rhinitis patients.Twenty-six allergic rhinitis patients, 12 males and 14 females were recruited in this study. Subjects were diagnosed by a physician based on history, physical examination, and positive reaction to a skin prick test. Subjects were randomly assigned to two groups. The control allergic rhinitis group received education and maintained normal life. The aquatic group performed aquatic exercise for 30 minutes a day, three days a week for six weeks. Heart rate variability, PNIF and lung functions were measured at the beginning, after three weeks and six weeks.There were statistically significant increased low frequency normal units (LF n.u., PNIF and showed decreased high frequency normal units (HF n.u. at six weeks after aquatic exercise compared with the control group.Six weeks of aquatic exercise could increase sympathetic activity and PNIF in allergicrhinitis patients.

  14. IQ Score of Children with Persistent or Perennial Allergic Rhinitis: A Comparison with Healthy Children

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    Javad GHAFFARI

    2014-07-01

    Full Text Available How to Cite This Article: Ghaffari J, Abbaskhanian A, Jalili M, Yazdani Charati Y. IQ Score of Children With Persistent or Perennial Allergic Rhinitis: Comparison with Healthy Children. Iran J Child Neurol. 2014 Summer; 8(3: 44-48. AbstractObjectivePrevalence of allergies is different around the world. Allergic rhinitis is a common chronic disease in children.Intelligence quotient (IQ is an indicator of efficacy and many factors including chronic diseases may affect it. This study compares the IQs of children diagnosed with persistent or perennial allergic rhinitis with healthy children.Material & MethodsThis was a comparative study that was conducted from June 2011–May 2013 in an academic referral clinic. In this study, 90 patients aged 6- to 14-yearsold who were diagnosed with persistent or perennial allergic rhinitis and were compared to 90 age and gender match healthy patients from their respective families. The Wechsler Intelligence Scale for hildren was used to divide and calculate overall IQ, verbal IQ, and practical IQ. The t-test and chi square were used to analyze quantitative variables and qualitative variables, respectively.Results In this study, out of total 180 children, 90 (50% in the case group and 90 children (50%, the control group participated for IQ comparison. One hundred (57% were male and 80 (43% were female. The overall IQ for allergic rhinitis patients and healthy patients was 109.2 and 107.5, respectively. This difference was not considered significant. Furthermore, there was no significant difference between the IQ scores of males and females.ConclusionAlthough allergic rhinitis is a chronic disease and effects quality of life, there were no identifiable negative effects on IQ.  ReferencesGhaffari J, Mohammadzadeh I, Khaliian A, Rafatpanah H, Mohammadjafari H, Davoudi A. Prevalence of asthma, allergic rhinitis and eczema in elementary schools in Sari(Iran. Caspian Journal of Internal Medicine

  15. Social class in asthma and allergic rhinitis: a national cohort study over three decades.

    Science.gov (United States)

    Bråbäck, L; Hjern, A; Rasmussen, F

    2005-12-01

    The aim of this study was to assess whether the association with social class differed between allergic rhinitis and asthma and whether these associations have changed over time. The Swedish Military Service Conscription Register was linked to two other national registers for 1,247,038 male conscripts in successive cohorts born between 1952 and 1977. The percentage of asthma cases associated with allergic rhinitis was 15% in the oldest cohort and 44% in the youngest cohort. Low socio-economic status (SES) was associated with an increased risk (assessed as odds ratio) of asthma without allergic rhinitis (1.14, 95% confidence interval (CI) 1.11-1.17) but a slightly reduced risk of asthma with allergic rhinitis (0.96, 95% CI 0.93-1.00). The risk of allergic rhinitis was 0.84, 95% CI 0.82-0.85. A positive interaction between SES and year of birth occurred in all three conditions. Low SES was related to a reduced risk of asthma with allergic rhinitis in the earliest cohort (0.72, 95% CI 0.53-0.82) but a slightly increased risk in the most recent cohort (1.07, 95% CI 1.01-1.14). In conclusion, the role of social class has changed over time. The steepest increase in asthma and allergic rhinitis occurred in conscripts with a low socio-economic status.

  16. Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Adner Mikael

    2008-03-01

    Full Text Available Abstract Background S100A7 is a calcium-binding protein with chemotactic and antimicrobial properties. S100A7 protein levels are decreased in nasal lavage fluid from individuals with ongoing allergic rhinitis, suggesting a role for S100A7 in allergic airway inflammation. The aims of this study were to describe genetic variation in S100A7 and search for associations between this variation and allergic rhinitis. Methods Peripheral blood was collected from 184 atopic patients with a history of pollen-induced allergic rhinitis and 378 non-atopic individuals, all of Swedish origin. DNA was extracted and the S100A7 gene was resequenced in a subset of 47 randomly selected atopic individuals. Nine polymorphisms were genotyped in 184 atopic and 378 non-atopic individuals and subsequently investigated for associations with allergic rhinitis as well as skin prick test results. Haplotypes were estimated and compared in the two groups. Results Thirteen polymorphisms were identified in S100A7, of which 7 were previously undescribed. rs3014837 (G/C, which gives rise to an Asp → Glu amino acid shift, had significantly increased minor allele frequency in atopic individuals. The major haplotype, containing the major allele at all sites, was more common in non-atopic individuals, while the haplotype containing the minor allele at rs3014837 was equally more common among the atopic individuals. Additionally, heterozygotes at this site had significantly higher scores in skin prick tests for 9 out of 11 tested allergens, compared to homozygotes. Conclusion This is the first study describing genetic variation, associated with allergy, in S100A7. The results indicate that rs3014837 is linked to allergic rhinitis in our Swedish population and render S100A7 a strong candidate for further investigations regarding its role in allergic inflammation.

  17. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

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    Uddman Rolf

    2005-09-01

    Full Text Available Abstract Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been shown in several studies, but their possible function as mediators in allergy and asthma remains to be established. The present study was designed to examine the expression of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with intermittent allergic rhinitis, focusing on changes induced by exposure to pollen. Methods 27 healthy controls and 42 patients with seasonal allergic rhinitis volunteered for the study. Nasal biopsies were obtained before and during pollen season as well as before and after allergen challenge. The seasonal material was used for mRNA quantification of Toll-like receptors 2, 3 and 4 with real-time polymerase chain reaction, whereas specimens achieved in conjunction with allergen challenge were used for immunohistochemical localization and quantification of corresponding proteins. Results mRNA and protein representing Toll-like receptors 2, 3 and 4 could be demonstrated in all specimens. An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season. Conclusion The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation.

  18. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

    DEFF Research Database (Denmark)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W;

    2016-01-01

    decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les......The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical...

  19. Reactions of healthy persons and persons suffering from allergic rhinitis when exposed to office dust

    DEFF Research Database (Denmark)

    Hauschildt, Pernille; Mølhave, Lars; Kjærgaard, Søren K.

    1999-01-01

    Objectives Reactions to airborne office dust among healthy subjects and subjects suffering from allergic rhinitis were investigated. Methods Twelve healthy and 11 subjects suffering from allergic rhinitis were exposed to clean air [17 (SD 2) mg/m3] and office dust [439 (SD 68) mg/m3] for 245...... exposure, and some of the indications were in biologically unexplainable directions. No difference in the reactions to dust was observed between the healthy subjects and the subjects suffering from allergic rhinitis. Conclusion Dust does not seem to have objective or subjective effects on humans, as only...

  20. A Model for the Determination of Pollen Count Using Google Search Queries for Patients Suffering from Allergic Rhinitis

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    Volker König

    2014-01-01

    Full Text Available Background. The transregional increase in pollen-associated allergies and their diversity have been scientifically proven. However, patchy pollen count measurement in many regions is a worldwide problem with few exceptions. Methods. This paper used data gathered from pollen count stations in Germany, Google queries using relevant allergological/biological keywords, and patient data from three German study centres collected in a prospective, double-blind, randomised, placebo-controlled, multicentre immunotherapy study to analyse a possible correlation between these data pools. Results. Overall, correlations between the patient-based, combined symptom medication score and Google data were stronger than those with the regionally measured pollen count data. The correlation of the Google data was especially strong in the groups of severe allergy sufferers. The results of the three-centre analyses show moderate to strong correlations with the Google keywords (up to >0.8 cross-correlation coefficient, P < 0.001 in 10 out of 11 groups (three averaged patient cohorts and eight subgroups of severe allergy sufferers: high IgE class, high combined symptom medication score, and asthma. Conclusion. For countries with a good Internet infrastructure but no dense network of pollen traps, this could represent an alternative for determining pollen levels and, forecasting the pollen count for the next day.

  1. Minnesota multiphasic personality inventory of patients with allergic rhinitis%变应性鼻炎患者心理人格特征研究

    Institute of Scientific and Technical Information of China (English)

    锡琳; 张伟; 赵岩; 张罗

    2011-01-01

    Objective To explore the relationship between allergic rhinitis(AR) and personality traits in nonpsychiatric population of allergic status. Methods Subjects were assigned to the allergic (84 cases) or nonallergic health group (37 cases) on the basis of skin prick test (SPT) and allergic symptoms. The psychological aspects of subjects were assessed by using the minnesota muliphasic personality inventory (MMPI). Results The allergic group scored higher than the nonallergic group on five clinical scales, hypochondriasis ( Hs ), depression ( D), hysteria ( Hy ), hypomania ( Ma ), social introversion ( Si ), and one research scale manifest aniety scale (Mas). The differences were significant ( t value was respectively 2. 169, 2.711, 2.010, 2.577, 2.390 and 2. 196, all P <0.05). In addition, the grade of resultant skin wheal was positively correlated with T scores on the Hs, Hy, psychopathic deviance (Pd) and psychasthenia ( Pt ). The r value was 0. 366, 0. 449, 0. 345 and 0. 355 respectively ( all P < 0. 05 ).Conclusion Subjects with AR show poorer psychological functioning, indicating the close relationship between AR and psychological status.%目的 探讨变应性鼻炎(allergic rhinitis,AR)患者的基本心理人格特征.方法 应用明尼苏达多相个性调查表(minnesota muliphasic personality inventory,MMPI)分析84例AR患者和37例健康对照者的心理人格特征.结果 AR患者在疑病量表(hypochondriasis,Hs)、抑郁量表(depression,D)、癔病量表(hysteria,Hy)、轻躁狂量表(hypomania,Ma)、社会内向量表(social introversion,Si)5个临床量表T分和外显焦虑量表(manifest aniety scale,Mas)T分明显高于健康对照(t值分别为2.169、2.711、2.010、2.577、2.390、2.196,P值均<0.05).皮肤点刺风团等级与Hs、Hy、精神病态量表(psychopathic deviance,Pd)、精神衰弱量表(psychasthenia,Pt)的T分呈正相关(r值分别为0.366、0.449、0.345、0.355,P值均<0.05),风团直径越大患者Hs、Hy、Pd

  2. Association between Allergic Rhinitis and Asthma Control in Peruvian School Children: A Cross-Sectional Study

    Directory of Open Access Journals (Sweden)

    Justo Padilla

    2013-01-01

    Full Text Available Background. Asthma and allergic rhinitis are highly prevalent conditions that cause major illness worldwide. This study aimed to assess the association between allergic rhinitis and asthma control in Peruvian school children. Methods. A cross-sectional study was conducted among 256 children with asthma recruited in 5 schools from Lima and Callao cities. The outcome was asthma control assessed by the asthma control test. A score test for trend of odds was used to evaluate the association between allergic rhinitis severity and the prevalence of inadequate asthma control. A generalized linear regression model was used to estimate the adjusted prevalence ratios of inadequate asthma control. Results. Allergic rhinitis was present in 66.4% of the population with asthma. The trend analysis showed a positive association between allergic rhinitis and the probability of inadequate asthma control (. It was associated with an increased prevalence of inadequate asthma control, with adjusted prevalence ratios of 1.53 (95% confidence interval: 1.19−1.98. Conclusion. This study indicates that allergic rhinitis is associated with an inadequate level of asthma control, giving support to the recommendation of evaluating rhinitis to improve asthma control in children.

  3. Plasminogen activator inhibitor-1 gene 4G/5G polymorphism in Turkish children with asthma and allergic rhinitis.

    Science.gov (United States)

    Ozbek, Ozlem Yilmaz; Ataç, F Belgin; Ogus, Ersin; Ozbek, Namik

    2009-01-01

    Plasminogen activator inhibitor (PAI-1) has an essential role in tissue remodeling after inflammation. Recent literature revealed only one study evaluating PAI-1 4G/5G gene polymorphism in children with asthma and none in children with allergic rhinitis. We aimed to investigate distribution of PAI-1 4G/5G polymorphism in a group of Turkish children with asthma and allergic rhinitis and compare these findings with those obtained in normal peers. Patients with physician-diagnosed asthma (n = 106) and allergic rhinitis (n = 99) and 83 healthy peers were included in this study. We evaluated PAI-1 4G/5G polymorphism genotype as well as the possible association between PAI-1 4G/5G polymorphism and pulmonary function tests, serum total immunoglobulin E (IgE), total eosinophil count, and skin-prick test positivity in our study. The prevalence of the 4G allele significantly exceeded the values found in the controls both in patients with asthma (p = 0.001) and in patients with allergic rhinitis (p = 0.002). Interestingly, comparison of asthmatic patients revealed that mean baseline percent forced expiratory volume in 1 second and forced vital capacity were significantly higher in patients who bear 5G/5G genotype than in those who have 4G/4G or 4G/5G genotypes. No statistically significant relationship were found between PAI-1 polymorphism and total serum IgE levels, total eosinophil count, or selected skin test responses to aeroallergens. Our study suggests that Turkish children with asthma or allergic rhinitis have a higher prevalence of PAI-1 4G allele compared with their healthy peers.

  4. Current issues on sublingual allergen-specific immunotherapy in children with asthma and allergic rhinitis

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    Živković Zorica

    2016-01-01

    Full Text Available In 1993 the European Academy of Allergy and Clinical Immunology was the first official organization to recognize that sublingual administration could be “promising route” for allergic desensitization. A few years later, the World Health Organization recommended this therapy as “a viable alternative to the injection route in adults.” The first meta-analysis showed sublingual allergen specific immunotherapy (SLIT effectiveness for allergic rhinitis and another study showed SLIT can actually help prevent the development of asthma both in adults and in children. The main goal of this review article is to present insight into the most up-to-date understanding of the clinical efficacy and safety of immunotherapy in the treatment of pediatric patients with allergic rhinitis and asthma. A literature review was performed on PubMed from 1990 to 2015 using the terms “asthma,” “allergic rhinitis,” “children,” “allergen specific immune therapy.” Evaluating data from double-blind placebo-controlled randomized clinical trials (DB-PC-RCTs, the clinical efficacy (assessed as the reduction of symptom score and the need of rescue medicament of SLIT for allergic rhinitis and allergic asthma, has been confirmed in various meta-analysis Outcomes such as rhinoconjunctivitis score and medication scores, combined scores, quality of life, days with severe symptoms, immunological endpoints, and safety parameters were all improved in the SLIT-tablet compared with placebo group. SLIT safety has been already proven in many DB-PC-RCTs and real-life settings. In accordance with all of the above mentioned, the goals for future trials and studies are the development of comprehensive guidelines for clinical practice on immunotherapy, embracing all the different potential participants. The importance of allergen immunotherapy is of special relevance in the pediatric age, when the plasticity and modulability of the immune system are maximal, and when

  5. Role of bilastine in the management of allergic rhinitis and urticaria: an Asia-Pacific consensus statement.

    Science.gov (United States)

    Mösges, Ralph; Lee, Dennis Lip Yen; Abong, Jovilia; Siasoco, Bella; Chow, Steven Kw; Leong, Jern-Lin; Singh, Harvinder; Kuljit, S; Campomanes, Benjamin

    2016-01-01

    The prevalence of allergic diseases is increasing globally, most particularly in middle- to low-income countries. This article examines the burden of allergic rhinitis and chronic urticaria in the Asia-Pacific region, unmet clinical needs, and the potential role of bilastine in the management of these conditions. An International Advisory Group meeting was convened in association with the Asian Pacific Society of Respirology Annual Congress in November 2014, followed by a literature review, and consensus-based outcomes from the meeting and literature review are described. Regional estimates of the prevalence of allergic rhinitis range from 10% to 50%, while little is known regarding the burden of urticaria in the Asia-Pacific region. A survey of allergy patients in the region identified fast, complete, and long-lasting symptom relief as the medication attributes most important to patients. International treatment guidelines for allergic rhinitis and urticaria advocate the first-line use of second-generation, no-sedating H1-antihistamines, such as bilastine, over their first-generation counterparts and a range of these agents are available to Asia-Pacific patients. The newer agents possess many of the properties of an "ideal" antihistamine (once daily administration, rapid and complete symptom relief, limited potential for drug-drug interactions, minimal side effects). The burgeoning prevalence of allergic diseases in the Asia-Pacific region and the uncontrolled symptoms that these patients experience demand a new antihistamine that offers the highest number of positive features according to the international guidelines.

  6. The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis.

    Science.gov (United States)

    Lee, Chih-Fang; Sun, Hai-Lun; Lu, Ko-Hsiu; Ku, Min-Sho; Lue, Ko-Huang

    2009-08-01

    Cetirizine (Zyrtec) is a potent and long-acting second-generation histamine H1- receptor antagonist for the treatment of allergic disease, such as allergic rhinitis and chronic idiopathic urticaria, in adult and child. It is a racemic mixture of levocetirizine (Xyzal) and dextrocetirizine. The purpose of this present study was to compare the efficacy of cetirizine, levocetirizine and placebo for the treatment of pediatric perennial allergic rhinitis. 74 perennial allergic rhinitis patients, aged 6 to 12 years old, assigned to 1 of 3 treatment groups for 12 weeks randomly. The effects of the three agents were compared with the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) and Total Symptom Score (TSS) by diary. Nasal peak expiratory flow rate (nPEFR) and laboratory examinations including serum immunoglobulin E level, eosinophil cationic protein (ECP), blood eosinophil counts and eosinophil percentage in a nasal smear were evaluated among the three groups. The results revealed that both cetirizine and levocetirizine improved TSS in comparison with the placebo group, and ceterizine appeared to be more efficacious than levocetirizine at week 8 and week 12. The PRQLQ score showed significant decreased both in cetirizine and levocetirizine group, but there was no statistic significant difference between both groups. The eosinophil proportion in a nasal smear significantly decreased among the cetirizine in comparison with the placebo group but there was no statistic significant in levocetirizine groups. Both cetirizine and levocetirizine showed significant improvement in nPEFR in comparison with the placebo group, and ceterizine appeared to be more efficacious than levocetirizine. The 12-week treatment program showed that cetirizine was more effectious than levocetirizine.

  7. [Allergic rhinitis in asthmatic patients].

    Science.gov (United States)

    Reyes, Paola; Larreal, Yraima; Arias, Julia; Rincón, Enrique; Valero, Nereida

    2014-01-01

    Antecedentes: la rinitis alérgica y el asma bronquial son procesos inflamatorios crónicos de las vías respiratorias, con una correlación que varía entre 28 y 78%. Objetivos: determinar la prevalencia de rinitis alérgica en pacientes asmáticos y clasificarla según las guías Rinitis Alérgica y su Impacto en Asma (ARIA), así como detectar las concentraciones séricas de IgE total y la existencia de eosinofilia nasal y en sangre periférica. Material y método: estudio en el que pacientes asmáticos entre 7 y 14 años de edad, consultantes del servicio de Pediatría del Hospital General del Sur Dr. Pedro Iturbe, Maracaibo, Estado Zulia, Venezuela, fueron encuestados acerca de signos y síntomas sugerentes de rinitis alérgica y su efecto en la calidad de vida. Se tomaron muestras sanguíneas e hisopado nasal para hacer las determinaciones objeto de estudio. Resultados: se evaluaron 60 pacientes asmáticos, 73.3% del sexo masculino y 70% escolares. La prevalencia de rinitis alérgica se estableció en 93.3%, el tipo más frecuente según ARIA fue el intermitente leve, con 42.8%. El signo clínico más frecuente fueron las ojeras alérgicas (86.6%) y el síntoma predominante fue el goteo nasal acuoso (83.3%), la afectación en cuanto a calidad de vida estuvo representada por trastornos del sueño (39.2%). El 85.7% de los encuestados tuvo porcentajes de eosinófilos mayores a 3% y 75% tuvo valores mayores de 100 UI de IgE total sérica. El 61.9% de las muestras de moco nasal de pacientes con rinitis mostró porcentajes de eosinófilos mayores a 10%. Conclusión: existe alta prevalencia de rinitis alérgica en asmáticos confirmada mediante pruebas de laboratorio que evidencian una respuesta inflamatoria mediada por IgE.

  8. Determinants of allergic rhinitis in young children with asthma.

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    Lise Moussu

    Full Text Available BACKGROUND: In the preschool period, allergic rhinitis (AR is infrequent and thus under-diagnosed. However, recent works have highlighted the occurrence of AR in toddlers although the causes of AR in this young population remain unknown. The objective of this study was to identify determinants of AR in young children with asthma. METHODS: We carried out a case-control study of 227 children with active asthma and enrolled in the Trousseau Asthma Program. AR and other allergic diseases (asthma, food allergy and eczema were diagnosed by medical doctors using standardized questionnaires. Parental history of AR and asthma, biological markers of atopy (total IgE, blood eosinophilia, allergic sensitization towards food and aeroallergens and environmental parameters were also collected. RESULTS: Forty one of the children (18.1% had AR. By univariate logistic regression analysis, AR was mainly associated with peanut sensitization (OR = 6.75; p = 0.002; food allergy (OR = 4.31; p = 0.026; mold exposure (OR = 3.81 p<0.01 and parental history of AR (OR = 1.42; p = 0.046. Due to the strong link between food allergy and peanut sensitization three models of multivariate logistic regression were performed and confirmed that AR is associated with peanut sensitization but also food allergy and mold exposure. A random forest analysis was also performed to explain AR. The results reinforced the logistic analysis that peanut sensitization and mold exposure were the principal determinants of AR. CONCLUSIONS & CLINICAL RELEVANCE: These results stress the importance of investigating AR in young children with asthma to potentially diagnose a particularly severe allergic asthmatic phenotype. Moreover, these data evoke the hypothesis that peanut could be an aeroallergen.

  9. Comparison of intranasal hypertonic dead sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis.

    Science.gov (United States)

    Cordray, Scott; Harjo, Jim B; Miner, Linda

    2005-07-01

    Intranasal corticosteroids are well known to be efficacious in the treatment of allergic rhinitis. Nasal irrigation with saline, including hypertonic saline, has long been recommended for the treatment of sinonasal disease, and it has been shown to have a positive effect on the physiology of the nasal mucosa. Until now, no study of the clinical efficacy of intranasal hypertonic Dead Sea saline as a monotherapy for seasonal allergic rhinitis has been reported. We conducted a prospective, randomized, single-blind, placebo-controlled comparison of intranasal hypertonic Dead Sea saline spray and intranasal aqueous triamcinolone spray in 15 patients with seasonal allergic rhinitis. Results were based on a 7-day regimen. Based on Rhinoconjunctivitis Quality of Life Questionnaire scores, clinically and statistically significant (p Dead Sea saline solution can be an effective alternative in mild-to-moderate allergic rhinitis, particularly with respect to nasal and eye symptoms. The hypertonicity of the Dead Sea solution may have a positive effect on the physiology of the nasal mucosa by improving mucociliary clearance. In addition, the dominant cation in the Dead Sea solution--magnesium--probably exerts anti-inflammatory effects on the nasal mucosa and on the systemic immune response.

  10. Probiotics and allergic rhinitis%益生菌与变应性疾病

    Institute of Scientific and Technical Information of China (English)

    黄石; 赵宇

    2013-01-01

    The prevalence of allergic diseases has increased in recent years, and primary prevention of allergic disease is considered to be an elusive goal. This paper summarizes the recent publications on probiotics in allergic rhinitis. It focuses on clinical and laboratory observations of treatment or prevention of allergic rhinitis. Probiotics administration represents different outcome, its effects depend on a variety of factors, such as dosing regimen, delivery method and the types of bacterium. Since the data from different research centers are conflicting, the further studies are required.

  11. Survey on the Prevalence of Allergic Rhinitis and its Effect on the Quality of High School Students’ Life

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    Maryam Amizadeh

    2013-03-01

    Full Text Available Introduction: Allergic rhinitis (AR is a common airway disease. In order to study  the  prevalence of  AR in high school students  in  Kerman, the Score for Allergic Rhinitis (SFAR was used and the quality of life  in  the  students  affected  by  rhinitis was  evaluated using the SF-36 questionnaire.   Materials and Methods: This was a cross-sectional, analytical, descriptive study, based on the SFAR scale. Quality of life in students with AR was evaluated using the SF-36 questionnaire.   Results: From 1511 students who completed the SFAR questionnaire, 291 (52.6%, girls; 47.4%, boys  had AR. Domestic dust was the most common cause of the disease. The most common symptoms of AR were rhinorrhea (76.6%, epiphora (76.3%, nasal congestion (64.3%, and itching (54.3%. According to the ARYA scale, (Allergic Rhinitis and its Impact on Asthma, 41.9% of students had moderate-to-severe rhinitis and 58.1% had mild rhinitis. A total of 43.1% of patients with moderate-to-severe rhinitis had a persistent condition and 56.9% had an intermediate condition. Results of the SF-36 questionnaire among students with AR showed a significant difference in physical functioning and bodily pain in comparison with healthy students.   Conclusion:  The results of this study show that the prevalence of AR among Kerman high school students is 19.3%. Because of the effect of this disease on the life quality of high school students in terms of both physical functioning and bodily pain, efforts should be made to reduce allergen levels as far as possible.

  12. Aeroallergen spectrum of patients with allergic rhinitis in Enshi area%恩施州地区变应性鼻炎患者的吸入变应原谱分析

    Institute of Scientific and Technical Information of China (English)

    刘军; 周意; 万静; 刘忠

    2011-01-01

    目的:调查恩施州地区变应性鼻炎患者变应原的分布,并分析其相关因素.方法:应用13种标准化吸入变应原对463例疑似变应性鼻炎患者进行皮肤点刺实验,并详细采集病史资料.结果:387例(83.6%)患者变应原呈阳性反应,阳性率相对较高的变应原依次为粉尘螨、屋尘螨、热带螨、美洲大蠊、德国小蠊及狗毛.对单类变应原呈阳性反应的占51.9%,其中大多数是螨类,占49.6%.变应原阳性强弱与家族史、是否伴哮喘、年龄及居住环境显著相关.结论:恩施州地区变应性鼻炎的主要变应原为尘螨,其阳性强弱与遗传、哮喘、年龄及居住环境有关.%Objective: To investigate aeroallergen spectrum of patients with allergic rhinitis in Enshi area and analyze its related factors. Method:Skin prick test was carried out in 463 patients with allergic rhinitis with 13 inhaled allergens. Detailed history was collected in all cases. Result: Three hundred and eigty-seven cases(83. 6 %)showed positive reaction to at least one allergen of 13 allergens. The most common allergens found in patients were dermatophagoides farinae and dermatophagoides pteronyssinus, followed by tropical mite、periplaneta americana,blattella germanica and dog hair. The positive reaction rate of single specie allergen were 51.9%, and most of them was positive to mites(49. 6 %). The positive reaction degree was significantly related to family history, asthma ,age and housing enviroment. Conclusion:The major allergen of allergic rhinitis was mite. The positive reaction degree related to genetics, asthma, age and housing enviroment.

  13. Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis

    OpenAIRE

    Lina Mattson; Antonio Lentini; Gawel, Danuta R.; Tejaswi V. S. Badam; Mikael Benson; Torbjorn Ledin; Nestor, Colm E; Mika Gustafsson; Jordi Serra-Musach; Janne Bjorkander; Zou Xiang; Huan Zhang

    2016-01-01

    Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4...

  14. Google unveils a glimpse of allergic rhinitis in the real world.

    Science.gov (United States)

    Kang, M-G; Song, W-J; Choi, S; Kim, H; Ha, H; Kim, S-H; Cho, S-H; Min, K-U; Yoon, S; Chang, Y-S

    2015-01-01

    Google Trends (GT) is a Web-based surveillance tool used to explore the searching trends of specific queries on Google. Recent studies have suggested the utility of GT in predicting outbreaks of influenza and other diseases. However, this utility has not been thoroughly evaluated for allergic diseases. Therefore, we investigated the utility of GT for predicting the epidemiology of allergic rhinitis. In the USA, GT for allergic rhinitis showed repetitive seasonality that peaked in late April and early May and then rapidly decreased, and a second small peak occurred in September. These trends are highly correlated with the searching trends for other queries such as 'pollen count', antihistamines such as loratadine and cetirizine (all r > 0.88 and all P Google Trends for allergic rhinitis was similar to the monthly changes in rhinitis symptoms according to the US National Health and Nutrition Examination Survey III, sales for Claritin(®) and all over-the-counter antihistamines, and the number of monthly page views of 'claritin.com'. In conclusion, GT closely reflects the real-world epidemiology of allergic rhinitis in the USA and could potentially be used as a monitoring tool for allergic rhinitis.

  15. Allergic rhinitis in northern vietnam: increased risk of urban living according to a large population survey

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    Lâm Hoàng

    2011-08-01

    Full Text Available Abstract Background Little is known about prevalence and risk factors of allergic rhinitis and chronic nasal symptoms among adults in Vietnam. We aimed to estimate the prevalence, risk factor patterns and co-morbidities of allergic rhinitis and chronic nasal symptoms in one urban and one rural area in northern Vietnam. Methods A cross-sectional questionnaire survey was conducted from August 2007 to January 2008 in urban Hoankiem and rural Bavi in Hanoi among adults aged 21-70 years. Of 7008 randomly selected subjects, 91.7% participated in Bavi and 70.3% in Hoankiem. Results Allergic rhinitis ever or chronic nasal symptoms were reported by 50.2%. The prevalence of allergic rhinitis ever was considerably higher in Hoankiem compared to Bavi, 29.6% vs 10.0% (p Conclusions Allergic rhinitis ever was considerably more common in the urban area. Nasal blocking and runny nose was each reported by about one third of the studied sample with no major urban-rural difference. Further, exposure to air pollution at work was significantly associated with allergic rhinitis ever, nasal blocking and runny nose.

  16. Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

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    Said Said A

    2012-11-01

    Full Text Available Abstract Background Allergic rhinitis is one of the commonest atopic diseases which contribute to significant morbidity world wide while its epidemiology in Tanzania remains sparse. There was paucity of information regarding allergic rhinitis in our setting; therefore it was important to conduct this study to describe our experience on allergic rhinitis, associated co-morbidities and treatment outcome in patients attending Bugando Medical Centre. Methods This was descriptive cross-sectional study involving all patients with a clinical diagnosis of allergic rhinitis at Bugando Medical Centre over a three-month period between June 2011 and August 2011. Data was collected using a pre-tested coded questionnaire and analyzed using SPSS statistical computer software version 17.0. Results A total of 190 patients were studied giving the prevalence of allergic rhinitis 14.7%. The median age of the patients was 8.5 years. The male to female ratio was 1:1. Adenoid hypertrophy, tonsillitis, hypertrophy of inferior turbinate, nasal polyps, otitis media and sinusitis were the most common co-morbidities affecting 92.6% of cases and were the major reason for attending hospital services. Sleep disturbance was common in children with adenoids hypertrophy (χ2 = 28.691, P = 0.000. Allergic conjunctivitis was found in 51.9%. The most common identified triggers were dust, strong perfume odors and cold weather (P χ2 = 4.583, P = 0.032. In this study family history of allergic rhinitis was not a significant risk factor (P =0.423. The majority of patients (68.8% were treated surgically for allergic rhinitis co morbidities. Post operative complication and mortality rates were 2.9% and 1.6% respectively. The overall median duration of hospital stay of in-patients was 3 days (2 – 28 days. Most patients (98.4% had satisfactory results at discharge. Conclusion The study shows that allergic rhinitis is common in our settings representing 14.7% of all

  17. Specific immunotherapy (SIT in the treatment of allergic rhinitis

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    Gorenoi, Vitali

    2010-03-01

    Full Text Available Scientific background: Allergic rhinitis (AR exhibits a prevalence of approx. 20% in Germany and causes enormous costs in the health care system. Specific immunotherapy (SIT is considered to be the only potentially causal therapy for AR and mainly administered by two routes, subcutaneous (SCIT and sublinguale (SLIT. SIT promises a reduction of symptoms and the need for medication in patients with AR. Research questions: The question arises, to what extent is SIT effective and cost effective in the treatment of AR and which ethical-social and legal aspects have to be considered regarding its application. Methods: The literature search was accomplished in the electronic data bases MEDLINE, EMBASE etc. in February 2008. The medical evaluation was based on systematic reviews of blinded, randomised controlled studies (RCT. The economic evaluation included health-economic studies on the basis of RCT. Additionally, it was also searched for publications explicitly addressing ethical-social and legal aspects of the use of SIT. Results: Medical evaluationTwo reviews on SCIT and three on SLIT were included in the medical evaluation. For the evaluation of SIT with grass pollen results for short and medium-term effects are considered from several studies, for SIT with other seasonal allergens (e. g. tree pollen and with house dust mite allergens from clearly fewer studies and for SIT with other perennial allergens only from a few. The reviews report a significant reduction of the symptom and medication score in favour of SCIT with seasonal allergens and recognise the effectiveness at least for grass pollen allergens. Also for other seasonal allergens SCIT is appraised as effective. The reviews about SLIT determine a significant reduction of the symptom and the medication score in favour of SLIT vs. placebo in short and medium term follow-up in evaluations across all allergens. The subgroup analyses show a significant reduction of the symptom and medication

  18. AN OPEN LABEL PILOT STUDY TESTING THE ROLE OF CLASSICAL HOMEOPATHY IN CHRONIC ALLERGIC RHINITIS

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    S. Ghosh*, S. Das, M. Mundle Dishari Sengupta, Sk. Intaj Hossain, M. Koley and S. Saha

    2013-04-01

    Full Text Available ABSTRACT: Purpose: The prevalence of allergic rhinitis (AR is increasing at an alarming rate throughout the world. India has an estimated number of 15-20 million patients with allergic bronchial asthma and 30-80% of these suffer from AR. So, AR is considered as a major chronic respiratory disease due to its prevalence, impact on quality of life (QoL, work/school performance and productivity, economic burden and links with asthma. This research aims at testing the role of classical homeopathy in bringing changes in serum immunoglobulin E (IgE level and absolute eosinophil count (primary outcome measures and symptoms score and WHOQOL-BREF score related to AR (secondary outcome measures by comparing the pre-trial and post-trial data.

  19. The role of atopy in Maltese patients with chronic rhinitis.

    Science.gov (United States)

    Agius, A M; Cordina, M; Calleja, N

    2004-06-01

    The global prevalence of allergic rhinitis has been on the increase and recent clinical experience in Malta has shown a similar trend. The aim of this study was to investigate the role of atopy in 415 patients presenting with rhinitis of at least 3 months duration, and to identify the common allergens responsible. Presenting clinical features, past and family history of seasonal allergic symptoms, exposure to cigarette smoking, pet ownership and occupation were analysed. All patients were skin tested for common allergens. Fifty-five per cent of patients were atopic, the main allergens responsible being house dust mite, cat dander and grass pollen. Rhinorrhoea and sneezing were significantly more common in atopic patients, who were more likely to have a past history and family history of seasonal asthma, eczema or rhinoconjunctivitis. Skin test-negative patients with idiopathic rhinitis were mostly females and tended to present a decade later. Differentiation between atopic and idiopathic chronic rhinitis may be helpful in the clinical setting in order to help predict response to treatment.

  20. Objective assessments of allergic and nonallergic rhinitis in young children

    DEFF Research Database (Denmark)

    Chawes, B L K; Kreiner-Møller, E; Bisgaard, H

    2009-01-01

    of age from the Copenhagen Prospective Study on Asthma in Childhood birth cohort assessing rhinitis history, specific immunoglobulin E relevant to rhinitis symptoms, nasal eosinophilia and nasal airway patency by acoustic rhinometry before and after decongestion. Associations were studied...

  1. Traffic exposure associated with allergic asthma and allergic rhinitis in adults. A cross-sectional study in southern Sweden

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    Montnémery Peter

    2009-05-01

    Full Text Available Abstract Background There is conflicting evidence that traffic-related air pollution is a risk factor for allergic conditions. Few studies have investigated this in adults. In adults, a high proportion of asthma, rhinitis and eczema is triggered by non-allergic factors. We investigated traffic as a risk factor for allergic versus non-allergic asthma and rhinitis, and eczema, in adults. A questionnaire from 2000 (n = 9319, 18–77 years provided individual data about disease outcome and self-reported traffic exposure. Additional exposure assessments were obtained using Geographical Informations Systems (GIS. Residential addresses were linked to the national Swedish Road Database and to a pollutant database with modelled annual means of NOx (Nitrogen Oxids. Results Living within 100 m from a road with a traffic intensity of >10 cars/min (24 hour mean was associated with prevalence of current asthma reported to be triggered by allergic factors (OR = 1.83, 95% CI = 1.23–2.72 and with allergic rhinitis (OR = 1.30, 95%CI = (1.05–1.61. No relation was seen with asthma or rhinitis triggered by other factors. Living within 100 m of a road with >10 cars/min was also associated with hand-eczema during the last 12 months (OR = 1.63, 95% CI = 1.19–2.23, but not with allergic eczema or diagnosed hand-eczema. Consistent results were seen using self-reported traffic, but the associations with NOx were less consistent. Conclusion Exposure to traffic was associated with a higher prevalence of allergic asthma and allergic rhinitis, but not with asthma or rhinitis triggered by non-allergic factors. This difference was suggested by the overall pattern, but only clear using GIS-measured traffic intensity as a proxy for traffic exposure. An association was also found with hand-eczema during the last 12 months. We suggest that asthma and rhinitis should not be treated as homogenous groups when estimating effects from traffic in adults.

  2. UK prescribing practices as proxy markers of unmet need in allergic rhinitis: a retrospective observational study

    Science.gov (United States)

    Price, David B; Scadding, Glenis; Bachert, Claus; Saleh, Hesham; Nasser, Shuaib; Carter, Victoria; von Ziegenweidt, Julie; Durieux, Alice M S; Ryan, Dermot

    2016-01-01

    Little data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database. We assessed diagnoses and prescription data for patients with a recorded diagnosis of rhinitis who took rhinitis medication during the study period. We assessed the data from 25,069 patients in 2009 and 22,381 patients in 2010. Monotherapy was the initial prescription of the season for 67% of patients with seasonal AR (SAR) and 77% of patients with nonseasonal upper airways disease (NSUAD), for both years. Initial oral antihistamine (OAH) or intranasal corticosteroid (INS) monotherapy proved insufficient for >20% of SAR and >37% of NSUAD patients. Multiple therapy was the initial prescription for 33% of SAR and 23% of NSUAD in both years, rising to 45% and >50% by season end, respectively. For NSUAD, dual-therapy prescriptions doubled and triple-therapy prescriptions almost tripled during both seasons. Many patients revisited their GP regardless of initial prescription. Initial OAH or INS monotherapy provides insufficient symptom control for many AR patients. GPs often prescribe multiple therapies at the start of the season, with co-prescription becoming more common as the season progresses. However, patients prescribed multiple therapies frequently revisit their GP, presumably to adjust treatment. These data suggest the need for more effective AR treatment and management strategies. PMID:27334893

  3. Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

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    Nilsson Daniel

    2012-08-01

    Full Text Available Abstract Background The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes. Methods A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls. Results The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding risk-associated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations. Conclusions Haplotypes in the TLR7-TLR8 gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.

  4. Herpes Simplex Type I Infection and Atopy Association in Turkish Children with Asthma and Allergic Rhinitis

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    Mahir Igde

    2009-09-01

    Full Text Available This study investigated the association between HSV-1 infection and atopy by comparing seropositivity to HSV-1 in atopic children with asthma and allergic rhinitis and in non-atopic children.Totally 249 children randomly selected from the university outpatient pediatric clinics were prospectively enrolled in the study between September 1 and November 30, 2007. Serum samples were examined using the virus neutralization test (VNT for HSV-1 Immunoglobulin G(IgG seropositivity. Skin prick tests (SPTs were performed to determine atopic status. The results showed that HSV-1 IgG seropositivity was significantly higher in atopic children (56.8% with asthma and allergic rhinitis than in the age-matched non-atopic children group (30.4% (pThese results support a possible relationship between the atopic status of children with asthma and allergic rhinitis and HSV-1 infection.

  5. The significance of allergen detection for eczema, allergic rhinitis and asthma patients%过敏原检测对湿疹、过敏性鼻炎和哮喘患者的意义

    Institute of Scientific and Technical Information of China (English)

    尧荣凤; 姜培红; 许国祥; 徐龙; 李智; 薛龙; 赵迪

    2015-01-01

    Objective To understand allergen IgE antibody distribution for different allergic diseases, in order to provide the reference for clinical prevention and treatment.Methods A total of 236 patients with allergic rhinitis, 250 patients with asthma and 275 patients with eczema were enrolled.Western blot was performed to detect the serological specific allergen IgE antibody.The allergens for allergic rhinitis, asthma and eczema were analyzed comparatively. Results The inhaled allergen detection rate was 41.66% in the 761 patients, and the ingested allergen detection rate was 8.28%.Dust mite(43.10%) was the most common allergen, and dog hair (12.22%),milk(11.43%) and house dust(10.78%) were the other 3 common allergens.The prevalence rates of dust mite(62.35%), dog hair(21.11%), house dust(18.89%) and milk (26.47%) in 11-30 years old group were higher than those in the other age groups (P 0.05).Conclusions Serum allergen detection might be conducive to identify the allergic status of patients, and provides a reliable reference to assist in the diagnosis of allergic diseases, prevent from environmental factors and make treatment plan.%目的:了解过敏原 IgE 抗体在不同过敏性疾病中的分布情况,为临床防治提供依据。方法采用免疫印迹法检测过敏性鼻炎(236例)、哮喘(250例)和湿疹(275例)患者血清过敏原特异性 IgE 抗体,同时对过敏性鼻炎、哮喘和湿疹患者的过敏原进行比较分析。结果761例患者吸入性过敏原检出率为41.66%,食入性过敏原检出率为8.28%;最常见的过敏原为户尘螨(43.10%)、狗毛皮屑(12.22%)、牛奶(11.43%)和屋尘(10.78%)。11~30岁组的户尘螨(62.35%)、狗毛皮屑(21.11%)、屋尘(18.89%)和牛奶(26.47%)阳性率明显高于其他年龄组(P <0.05)。湿疹患者蟑螂、牛奶和点青霉/分枝孢霉/烟曲霉/黑曲霉/交链孢霉的阳

  6. The impact of allergic rhinitis on sexual activity, sleep, and fatigue.

    Science.gov (United States)

    Benninger, Michael S; Benninger, Ryan M

    2009-01-01

    Allergic rhinitis (AR) has been found to impact the daily activities of allergic patients. This includes the effects on sleep and chronic fatigue. The effect of AR on sexual function has not been well studied. The purpose of this study was to assess the impact of AR on sexual function, sleep, and fatigue. The Rhinosinusitis Disability Index (RSDI) is a quality of life (QOL), validated outcomes tool that assesses how AR affects QOL. Specific questions address the adverse consequence on sexual function, sleep, and fatigue. Four subsets of patient with AR who completed the RSDI were evaluated for the specific questions as well as the physical, emotional, functional, and total scores. The scores were compared with a cohort of normal subjects, patients with a diffuse group of rhinologic disorders, and patients scheduled for septal surgery (non-AR patients). Patients with AR had significantly higher (worse) sexual and sleep RSDI scores than the non-AR patients and normal subjects. Although the AR subjects also had significantly higher fatigue RSDI scores than the normal subjects, there was no significant difference between the AR and non-AR patients' fatigue scores. Non-AR patients had significantly higher sexual, sleep, and fatigue RSDI scores than the normal subjects. AR has a significant negative impact on sexual function and can result in sleep disturbances and fatigue as measured by the RSDI.

  7. Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma.

    Science.gov (United States)

    Smolensky, Michael H; Lemmer, Bjoern; Reinberg, Alain E

    2007-08-31

    Study of the chronobiology of allergic rhinitis (AR) and bronchial asthma (BA) and the chronopharmacology and chronotherapy of the medications used in their treatment began five decades ago. AR is an inflammatory disease of the upper airway tissue with hypersensitivity to specific environmental antigens, resulting in further local inflammation, vasomotor changes, and mucus hypersecretion. Symptoms include sneezing, nasal congestion, and runny and itchy nose. Approximately 25% of children and 40% of adults in USA are affected by AR during one or more seasons of the year. The manifestation and severity of AR symptoms exhibit prominent 24-h variation; in most persons they are worse overnight or early in the morning and often comprise nighttime sleep, resulting in poor daytime quality of life, compromised school and work performance, and irritability and moodiness. BA is also an inflammatory medical condition of the lower airways characterized by hypersensitivity to specific environmental antigens, resulting in greater local inflammation as well as bronchoconstriction, vasomotor change, and mucus hypersecretion. In USA an estimated 6.5 million children and 15.7 million adults have BA. The onset and worsening of BA are signaled by chest wheeze and/or croupy cough and difficult and labored breathing. Like AR, BA is primarily a nighttime medical condition. AR is treated with H1-antagonist, decongestant, and anti-inflammatory (glucocorticoid and leukotriene receptor antagonist and modifier) medications. Only H1-antagonist AR medications have been studied for their chronopharmacology and potential chronotherapy. BA is treated with some of the same medications and also theophylline and beta2-agonists. The chronopharmacology and chronotherapy of many classes of BA medications have been explored. This article reviews the rather extensive knowledge of the chronobiology of AR and BA and the chronopharmacology and chronotherapy of the various medications used in their treatment.

  8. Masticatory Changes in Oral Breath Secondary to Allergic Rhinitis: Integrative Review

    Directory of Open Access Journals (Sweden)

    Bezerra, Luciana Ângelo

    2014-04-01

    Full Text Available Introduction The III Brazilian Consensus on Rhinitis (2012 defines allergic rhinitis as a nasal mucosa inflammation, mediated by immunoglobulin E, after exposure to allergens. The classic signs and symptoms of allergic rhinitis are nasal obstruction, watery rhinorrhea, sneezing, and nasal itching, often reversible either spontaneously or with treatment, and mouth breathing (breathing predominantly through the mouth, regardless of the cause, due to a nasal breathing impairment in some cases. Objective To evaluate the literature on masticatory changes in children with mouth breathing due to allergic rhinitis. Methods We conducted a search of the past 10 years, at Bireme and MEDLINE databases, for articles that covered masticatory changes in children with mouth breathing secondary to allergic rhinitis. Results We found 1,986 articles, including 15 repeated in databases, but only two articles met the inclusion criteria fully. Discussion We found few studies to answer the question raised in this review, and those studies have some methodological limitations. Most articles claimed no have statistically significant differences in masticatory changes in this population. Conclusion A better controlled study (isolating diseases, exposure time, with a larger sample (sample calculation appropriate, would be necessary to examine such changes.

  9. Rinite alérgica: indicadores de qualidade de vida Allergic rhinitis: indicators of quality of life

    Directory of Open Access Journals (Sweden)

    Inês Cristina Camelo-Nunes

    2010-02-01

    1997 and 2008. The following search terms were used: "allergic rhinitis"; "quality of life"; and "sleep disorders". Quality of life is often impaired in patients with allergic rhinitis, due to the classic symptoms of the disease (sneezing, pruritus, rhinorrhea and nasal obstruction. In addition, the pathophysiology of allergic rhinitis often disrupts sleep, leading to fatigue, irritability, memory deficits, daytime sleepiness and depression. The total burden of this disease goes beyond impairment of physical and social functioning. It has also a financial impact, which becomes greater when we consider the evidence that allergic rhinitis is a possible causal factor of comorbidities, such as asthma and sinusitis. Nasal obstruction, the most prominent symptom, is associated with sleep disorders, which can have a profound effect on mental health, learning, behavior and attention. Finally, allergic rhinitis-a chronic condition that affects adults, adolescents and children-is often underdiagnosed or inadequately treated. The deleterious impact that allergic rhinitis-related sleep disorders have on patient capacity to perform activities of daily living is an important component of the morbidity of the disease. With an accurate diagnosis, there are various available treatments that can reduce the burden of allergic rhinitis.

  10. Clinical efficacy of improved incision septoplasty for patients with allergic rhinitis%改良切口鼻中隔成形术治疗变应性鼻炎

    Institute of Scientific and Technical Information of China (English)

    王爱平; 孙海波

    2016-01-01

    Objective To analyze the clinical efficacy of improved incision septoplasty in treatment of allergic rhinitis and its effect on the life quality of patients.Methods A total of 42 patients with persistent allergic rhinitis and merge nasal septum in our hospital from July 2013 to April 2015 were divided into observation group and control group.The observation group were treated by improved incision septoplas-ty,and the control group received traditional KillIan incision treatment.The clinical efficacy,survival quality and visual analog scale between two groups were compared.Results After treatment,The total efficiency rate of observation group(94.24%)was significantly higher than that of control group(85.71%)(χ2 =7.15,P <0.05).The nasal congestion,nasal itching,sneezing and other symptoms score of observa-tion group were significantly lower than those of control group(P <0.05).The score of nasal problems,eye problems,eye problems and non-nasal sleep disorders in observation group were also significantly lower than those in control group(P <0.05).Intraoperative situation of ob-servation group was significantly better than that of control group(P <0.05).Conclusion Improved incision septoplasty has a good clinical efficacy for patients with persistent allergic rhinitis and merge nasal septum,which can significantly improve the clinical symptoms and life quality of patients.%目的:分析改良切口鼻中隔成形术治疗变应性鼻炎的临床疗效及对患者生存质量的影响。方法选取2013年7月至2015年4月在我院耳鼻喉科手术治疗的42例持续性中重度合并鼻中隔偏曲的变应性鼻炎患者,按手术方式不同分为观察组和对照组,观察组给予改良切口鼻中隔成形术治疗,对照组给予传统 KillIan 切口单纯鼻中隔黏膜切除术治疗,对2组患者的临床疗效,生存质量及视觉模拟评分进行比较。结果治疗后观察组总有效率94.24%,显著高于对照组的85.71

  11. The Link between Allergic Rhinitis and Asthma: A Role for Antileukotrienes?

    Directory of Open Access Journals (Sweden)

    H Kim

    2008-01-01

    Full Text Available Allergic rhinitis and asthma are both chronic heterogeneous disorders, with an overlapping epidemiology of prevalence, health care costs and social costs in quality of life. Both are inflammatory disorders with a similar pathophysiology, and both share some treatment approaches. However, each disorder has an array of treatments used separately in controlling these atopic disorders, from inhaled corticosteroids, beta2-agonists and antihistamines to newer monoclonal antibody-based treatments. The present article reviews the shared components of allergic rhinitis and asthma, and examines recent evidence supporting antileukotrienes as effective agents in reducing the symptoms of both diseases.

  12. 广东惠州地区成人支气管哮喘合并过敏性鼻炎的流行病学调查分析%Epidemiology analysis of patients with bronchial asthma combined with allergic rhinitis in Huizhou

    Institute of Scientific and Technical Information of China (English)

    吴峰; 林伟明; 陈宫玉; 陈钊成; 陈必达; 周五铁; 吴思仿; 吴海桂

    2012-01-01

    Objective To study the status of bronchial asthma (asthma) in patients with allergic rhinitis in Huizhou,and to analyze the correlation of clinical characteristic between allergic rhinitis and bronchial asthma,to investigate the patients' cognitions and treatment situation about the allergic rhinitis.Methods The questionnaire survey of 280 cases of asthma in Huizhou,their medical history,severity,asthma control test (ACT) were investigated in details.The rhinitis survey included prevalence,cognition,family history and treatment situation.The patients,data were collected and analyzed.Results In 280 cases of bronchial asthma,203 cases(72.5%) combined with allergic rhinitis.There was no statistical significance ( P >0.05) between the group of asthma combined with allergic rhinitis and the group of simple asthma on the age,sex,and the disease course.Compared with the group of simple asthma on case,the group of asthma combined with allergic rhinitis were more cases at the grade 2(mild persistence),grade 3(moderate persistence),and grade 4 (severe persistence),and few cases in complete control,good control through ACT ( P <0.05),while more cases in the uncontrol through ACT ( P <0.05).Allergic rhinitis:in the the group of asthma combined with allergic rhinitis,there were 59.61% of the patients got allergic rhinitis earlier than asthma,about 17.24% got those two disease at the same time.The inducements of allergic rhinitis were cold air (82.10%),irritant gas (61.58%),about 25.62% patients had been allergen tested,56.65 % patients had used drug treatment.27.10 % patients had family history of asthma or allergic rhinitis.Conclusions The morbidity of asthma combining with allergic rhinitis is high in Huizhou city,the cognition is low,and treatment status are not optimistic,which can be the basis of prevention and treatment in future.%目的 了解惠州地区支气管哮喘(简称哮喘)患者合并过敏性鼻炎的情况,分析两者在临床表现

  13. GATA3 Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population

    Science.gov (United States)

    Shirkani, Afshin; Mansouri, Atena; Abbaszadegan, Mohammad Reza; Faridhosseini, Reza; Jabbari Azad, Farahzad; Gholamin, Mehran

    2017-01-01

    Background: The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified. Methods: This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to evaluate a potential association between two GATA3 SNPs, rs1269486 and rs2229360, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR. Results: A statistically-significant association was found between rs1269486 and AR (Ppopulation. Because of the significance of this gene in AR, studying the association between GATA3 polymorphisms and AR is recommended for other populations. PMID:28367470

  14. Greater risk of incident asthma cases in adults with Allergic Rhinitis and Effect of Allergen Immunotherapy: A Retrospective Cohort Study

    Directory of Open Access Journals (Sweden)

    Piccillo Giovita

    2005-12-01

    Full Text Available Abstract Asthma and rhinitis are often co-morbid conditions. As rhinitis often precedes asthma it is possible that effective treatment of allergic rhinitis may reduce asthma progression. The aim of our study is to investigate history of allergic rhinitis as a risk factor for asthma and the potential effect of allergen immunotherapy in attenuating the incidence of asthma. Hospital-referred non-asthmatic adults, aged 18–40 years between 1990 and 1991, were retrospectively followed up until January and April 2000. At the end of follow up, available subjects were clinically examined for asthma diagnosis and history of allergen specific immunotherapy, second-hand smoking and the presence of pets in the household. A total of 436 non-asthmatic adults (332 subjects with allergic rhinitis and 104 with no allergic rhinitis nor history of atopy were available for final analyses. The highest OR (odds ratio associated with a diagnosis of asthma at the end of follow-up was for the diagnosis of allergic rhinitis at baseline (OR, 7.8; 95%CI, 3.1–20.0 in the model containing the covariates of rhinitis diagnosis, sex, second-hand smoke exposure, presence of pets at home, family history of allergic disorders, sensitization to Parietaria judaica; grass pollen; house dust mites; Olea europea: orchard; perennial rye; and cat allergens. Female sex, sensitization to Parietaria judaica and the presence of pets in the home were also significantly predictive of new onset asthma in the same model. Treatment with allergen immunotherapy was significantly and inversely related to the development of new onset asthma (OR, 0.53; 95%CI, 0.32–0.86. In the present study we found that allergic rhinitis is an important independent risk factor for asthma. Moreover, treatment with allergen immunotherapy lowers the risk of the development of new asthma cases in adults with allergic rhinitis.

  15. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.

    Directory of Open Access Journals (Sweden)

    Ekaterina Maslova

    Full Text Available BACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. RESULTS: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33 times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66 and medication (1.13, 95% CI: 0.98, 1.29 registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74 during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. CONCLUSION: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially

  16. Efficacy of sublingual swallow immunotherapy in children with rye grass pollen allergic rhinitis: a double-blind placebo-controlled study.

    Science.gov (United States)

    Ahmadiafshar, Akefeh; Maarefvand, Mina; Taymourzade, Babak; Mazloomzadeh, Saeedeh; Torabi, Zohreh

    2012-06-01

    Specific local immunotherapy has been recently introduced as an alternative to classic subcutaneous immunotherapy in treatment of allergic rhinitis. In this study, the effects of sublingual immunotherapy (SLIT) on symptoms and medication score and skin prick test evaluation of patients with allergic rhinitis were investigated.In this placebo controlled trial, twenty four patients aged 5-18 years old with grass pollen induced rhinitis and sensitive to rye grass by positive skin prick test received randomly sublingual extract of rye grass or placebo for 6 months. Symptom and medication scores and adverse effects of SLIT were assessed during treatment. Skin prick test induced wheal at the beginning and the end of therapy were also measured. Data were analyzed with SPSS software.We found significant reduction of symptoms in intervention group from 21st week of immunotherapy (pgrass and rye grass was significantly reduced in SLI group after immunotherapy.This study indicates that SLIT in grass-pollen rhinitis is well tolerated, improves overall clinical symptoms, and reduces drug consumes. We recommend this therapy as a safe therapy in patients with allergic rhinitis.

  17. Antigen-Specific Immunotherapy against Allergic Rhinitis: The State of the Art

    Directory of Open Access Journals (Sweden)

    Takashi Fujimura

    2010-01-01

    Full Text Available Allergic rhinitis is the most prevalent type I allergy in industrialized countries. Pollen scattering from trees or grasses often induces seasonal allergic rhinitis, which is known as pollinosis or hay fever. The causative pollen differs across different areas and times of the year. Impaired performance due to pollinosis and/or medication used for treating pollinosis is considered to be an important reason for the loss of concentration and productivity in the workplace. Antigen-specific immunotherapy is an only available curative treatment against allergic rhinitis. Subcutaneous injection of allergens with or without adjuvant has been commonly used as an immunotherapy; however, recently, sublingual administration has come to be considered a safer and convenient alternative administration route of allergens. In this review, we focus on the safety and protocol of subcutaneous and sublingual immunotherapy against seasonal allergic rhinitis. We also describe an approach to selecting allergens for the vaccine so as to avoid secondary sensitization and adverse events. The biomarkers and therapeutic mechanisms for immunotherapy are not fully understood. We discuss the therapeutic biomarkers that are correlated with the improvement of clinical symptoms brought about by immunotherapy as well as the involvement of Tr1 and regulatory T cells in the therapeutic mechanisms. Finally, we focus on the current immunotherapeutic approach to treating Japanese cedar pollinosis, the most prevalent pollinosis in Japan, including sublingual immunotherapy with standardized extract, a transgenic rice-based edible vaccine, and an immunoregulatory liposome encapsulating recombinant fusion protein.

  18. Sublingual immunotherapy in children with allergic rhinitis : quality of systematic reviews

    NARCIS (Netherlands)

    de Bot, Cindy M. A.; Moed, Heleen; Berger, Marjolein Y.; Roeder, Esther; van Wijk, Roy G.; van der Wouden, Johannes C.

    2011-01-01

    Systematic reviews have gained popularity as a way to combine the increasing amount of research information. This study assessed the quality of systematic reviews and meta-analyses of sublingual immunotherapy (SLIT) for allergic rhinitis in children, published since 2000. Eligible reviews were ident

  19. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis

    DEFF Research Database (Denmark)

    Costa, D J; Marteau, P; Amouyal, M;

    2014-01-01

    BACKGROUND/OBJECTIVES: An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out...

  20. Hormetic Effect of Chronic Hypergravity in a Mouse Model of Allergic Asthma and Rhinitis

    Science.gov (United States)

    Jang, Tae Young; Jung, Ah-Yeoun; Kim, Young Hyo

    2016-06-01

    We aimed to evaluate the effect of chronic hypergravity in a mouse model of allergic asthma and rhinitis. Forty BALB/c mice were divided as: group A (n = 10, control) sensitized and challenged with saline, group B (n = 10, asthma) challenged by intraperitoneal and intranasal ovalbumin (OVA) to induce allergic asthma and rhinitis, and groups C (n = 10, asthma/rotatory control) and D (n = 10, asthma/hypergravity) exposed to 4 weeks of rotation with normogravity (1G) or hypergravity (5G) during induction of asthma/rhinitis. Group D showed significantly decreased eosinophils, neutrophils, and lymphocytes in their BAL fluid compared with groups B and C (p lung homogenate, the expression of IL-1β was significantly upregulated (p lung parenchyma and turbinate, and the thickness of respiratory epithelium was significantly reduced in group D (p < 0.05). The expression of Bcl-2 and heme oxygenase-1 were significantly downregulated, Bax and extracellular dismutase significantly upregulated in Group D. Therefore, chronic hypergravity could have a hormetic effect for allergic asthma and rhinitis via regulation of genes involved in antioxidative and proapoptotic pathways. It is possible that we could use hypergravity machinery for treating allergic respiratory disorders.

  1. Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice

    Institute of Scientific and Technical Information of China (English)

    朱瑾; 吴军; 陈希炜; 易绍萱; 罗高兴; 贺伟峰

    2003-01-01

    Objective: To examine the role of recombinant adenovirus vector containing CTLA4Ig gene(Ad-CTLA4Ig) in the treatment of induced allergic rhinitis in mice.Methods: Allergic rhinitis was induced by sensitizing and challenging with ovalbumin(OVA).Ad-CTLA4Ig was intraperitoneally injected 30 min before OVA challenge.Adenovirus vector without inserted CTLA4Ig cDNA served as the control.The symptoms and morphological changes of nasal mucosa of each group were observed, and the serum levels of IgE against OVA were detected with ELISA.Results: There were no obvious symptoms and pathological changes in Ad-CTLA4Ig treated group, in which the serum OVA-specific IgE levels were significantly lower than that in control groups(P< 0.05).Conclusion: Ad-CTLA4Ig prevents and treats allergic rhinitis of mice,implying the possibility of the usage of Ad-CTLA4Ig against allergic rhinitis in clinic in future.

  2. 231 Pattern of Positive Sensitization in Patient with Asthma and Rhinitis to 3600 MSNM (La Paz, Bolivia)

    OpenAIRE

    Moncada Alcon, Abel Marcelo; Rios Mora, Roxana Ivon

    2012-01-01

    Background In the high altitude exists very few studies about allergies, we seek to give to know our sensitization in population with breathing problems (asthma and Allergic Rhinitis). Methods They were carried out allergy tests to 94 patients between 6 and 13 years with breathing symptoms predominantly allergic rhinitis and asthma. They were carried out allergy tests to foods like peanut, wheat, almond, tomato, milk, fish, soya, nuts, corn egg, chocolate, dog epithelia, cat, rabbit, feathers...

  3. Comparison of cetirizine with astemizole in the treatment of perennial allergic rhinitis and study of the concomitant effect on histamine and allergen-induced wheal responses.

    Science.gov (United States)

    Lobaton, P; Moreno, F; Coulie, P

    1990-11-01

    Thirty patients suffering from perennial allergic rhinitis took astemizole and cetirizine, 10 mg/d, under double-blind, crossover randomized conditions for 4 weeks. Four weeks washout separated the two periods. Nasal condition was improved, histamine and allergen-induced wheal responses were inhibited by both treatments with a slight advantage for cetirizine. Both treatments were well tolerated.

  4. 成都地区过敏性鼻炎患者过敏原的检测分析%Detection and analysis of allergens in allergic rhinitis patients in Chengdu

    Institute of Scientific and Technical Information of China (English)

    蒋锐明; 范敏; 谢亚柳; 袁洛花; 许琴

    2013-01-01

    目的 检测成都地区过敏性鼻炎(AR)患者血清中的过敏原情况,为临床诊断和治疗过敏性鼻炎提供实验室依据.方法 过敏性鼻炎患者88例及同期就诊的非过敏性鼻炎患者30例,采用酶免疫斑点法,检测患者血清中的吸入性和食入性过敏原共20项.结果 吸入性过敏原前3位为:屋尘螨/粉尘螨组合(65.9%)、屋尘(43.2%)狗上皮(9.1%);食入性过敏原前3位为:虾和海鱼组合(13.6%)、艾蒿(11.4%)、黄豆(10.2%).30例阴性对照仅有1例检测出阳性过敏原为虾和海鱼.结论 屋尘螨/粉尘螨和虾/海鱼分别是导致成都地区AR最主要的吸入性和食入性过敏原,有意识地避免接触这些过敏原及进行特异性的免疫治疗对防治过敏性鼻炎具有积极意义.%Objective To detect allergen in serum of patients with allergic rhinitis (AR) for diagnosis and treatment.Methods Sera from 88 AR patients and 30 non-allergic rhinitis controls were collected and detected for 20 kinds of allergen by using enzyme-linked immunospot assay.Results In Chengdu city,the positve rates arrangement of top 3 of inhalant allergens are house dust mite/dermatophagoides farinae (65.9%),house dust (43.2%) and dog epithelium (9.1%),respectively and of ingested allergens are shrimp/marine fish (13.6%),artemisia argyi (11.4%) and soybean (10.2%),respectively.Only 1 of 30 controls is allergic to shrimp and marine fish.Conclusion House dust mite/dermatophagoides farinae and shrimp/marine fish are the uppermost inhalant and ingested allergens recpectively which induced AR in Chengdu city.Dection of allergen is meaningful for patients to prevent suffering from AR disease by avoiding touching these allergens consciously,and it is important for clinicians to perform specific immunotherapy on AR patients.

  5. Aeroallergens, atopy and allergic rhinitis in the Middle East.

    Science.gov (United States)

    Goronfolah, L

    2016-01-01

    The literature on the nature and prevalence of indoor and/or outdoor aeroallergens, atopy and symptoms of rhinitis and asthma in the Middle East region (defined here as Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Palestine, Qatar, Kingdom of Saudi Arabia - KSA, Syria, United Arab Emirates and Yemen) was reviewed. Although documentation was poor in all countries other than Iran and the KSA, a wide range of "global" and "local" aeroallergens (grass, weed and tree pollens, fungal spores, insect allergens, dander, and house dust mites) has been observed across the region. The prevalence of current self-reported or parent-reported symptoms of rhinitis ranged from 9% to 38%. Researchers have suggested that the high atopy rates and self-reported rhinitis rates are associated with an on-going shift towards a "western" lifestyle.

  6. Seasonal variations of nasal resistance in allergic rhinitis and environmental pollen counts. II: Efficacy of preseasonal therapy.

    Science.gov (United States)

    Naito, K; Ishihara, M; Senoh, Y; Takeda, N; Yokoyama, N; Iwata, S

    1993-01-01

    We gave Mao-bushi-saishin-to, a Chinese blended medicine, and azelastine to an adult patient with hay fever due to Japanese cedar pollen and measured nasal resistance and ambient floating pollen counts throughout the time of Japanese cedar pollination in separated years. In the patient Mao-bushi-saishin-to was effective against preseasonal increases in nasal airway resistance but could not control severe episodes of allergic rhinitis caused by high dose exposure to Japanese cedar pollen and also perhaps caused by a priming effect. Azelastine inhibited both pre- and post-seasonal increases in nasal airway resistance but not only on high pollen counts days.

  7. Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

    OpenAIRE

    Zhu, Zheng; Xie, Yanqing; Guan, Weijie; Gao, Yi; Xia, Shu; Shi, Xu; Zheng, Jinping

    2016-01-01

    Background The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear. Objective To evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR. Methods Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life quest...

  8. Prevalence and risk factors for allergic rhinitis in two resource-limited settings in Peru with disparate degrees of urbanization

    Science.gov (United States)

    Baumann, L. M.; Romero, K. M.; Robinson, C. L.; Hansel, N. N.; Gilman, R. H.; Hamilton, R. G.; Lima, J. J.; Wise, R. A.; Checkley, W.

    2017-01-01

    Summary Background Allergic rhinitis is a disease with a high global disease burden, but risk factors that contribute to this condition are not well understood. Objective To assess the prevalence and risk factors of allergic rhinitis in two Peruvian populations with disparate degrees of urbanization. Methods We conducted a population-based, cross-sectional study on 1441 children aged 13–15 years at enrollment (mean age 14.9 years, 51% boys) to investigate the prevalence of allergic disease. We used a standardized, Spanish validated questionnaire to determine the prevalence of allergic rhinitis and asked about sociodemographics and family history of allergies. Children also underwent spirometry, exhaled nitric oxide, allergy skin testing to 10 common household allergens and provided a blood sample for measurement of 25OH vitamin D and total serum IgE. Results Overall prevalence of allergic rhinitis was 18% (95% CI 16% to 20%). When stratified by site, the prevalence of allergic rhinitis was 23% Lima vs. 13% in Tumbes (P eczema vs. 17% of those without eczema (P < 0.001). Important risk factors for allergic rhinitis were parental rhinitis (adjusted OR = 3.0, 95% CI 1.9–4.7 for 1 parent and adjusted OR = 4.4, 95% CI 1.5–13.7 for 2 parents); allergic sensitization to common household aeroallergens (1.6, 1.1–2.3); being overweight (1.5, 1.0–2.3); exhaled nitric oxide ≥20 ppb (1.9, 1.3–2.7); and total serum IgE ≥ 95th percentile (2.4, 1.2–4.8). Population attributable risk of important factors for allergic rhinitis were 25% for high exhaled nitric oxide, 22% for allergic sensitization to common household aeroallergens, 22% for paternal rhinitis, 10% for being overweight and 7% for an elevated total serum IgE. Conclusion and Clinical Relevance Allergic rhinitis was prevalent in both settings, and important risk factors include elevated exhaled nitric oxide, allergic sensitization to common household aeroallergens, parental rhinitis, being overweight and

  9. Uso de probióticos na rinite alérgica Probiotics in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Janaina Cândida Rodrigues Nogueira

    2011-02-01

    Full Text Available Probióticos são microrganismos viáveis, usados como suplemento alimentar, normalmente bactérias ácidas lácticas, que podem modificar a composição e/ou a atividade metabólica da microbiota intestinal, modulando o sistema imune de forma que beneficie a saúde do indivíduo. OBJETIVO: Fazer uma revisão sobre o uso de Probióticos (Lactobacillus e Bifidobacterium na rinite alérgica. MATERIAL E MÉTODO: Foram pesquisados artigos originais no Pubmed. RESULTADOS: Os resultados encontrados indicam que os probióticos, Lactobacillus e Bifidobacterium parecem prevenir as recorrências alérgicas, aliviar a severidade dos sintomas e promover melhora da qualidade de vida dos pacientes com rinite alérgica. Estes efeitos ocorrem devido à modulação do sistema imunológico através da indução da produção de citocinas que promovem uma resposta TH1 dominante em alérgicos, através do efeito da modulação no balanço TH1/TH2. CONCLUSÃO: O uso de bactérias probióticas pode ser uma forma efetiva e segura de prevenção e/ou tratamento de rinite alérgica, mas seu mecanismo exato de ação permanece desconhecido. No entanto, estudos clínicos usando probióticos e intervenção dietética deverão ser o foco de futuras investigações, para permitir um uso mais amplo.Probiotics are live microorganisms used as supplementary food, usually lactic acid bacteria that can change either the composition and/or the metabolic activities of the gut microbiota modulating the immune system in a way that benefits the person's health. AIM: To review the use of Probiotics (Lactobacillus and Bifidobacterium in allergic rhinitis patients. MATERIALS AND METHODS: Pubmed original articles were used as data source. RESULTS: Results indicate that probiotics, Lactobacillus and Bifidobacterium appear to prevent allergy recurrences, alleviate the severity of symptoms and improve the quality of life of patients with allergic rhinitis. This happens because of the immune

  10. Frequency of rhinitis and orofacial disorders in patients with dental malocclusion

    Science.gov (United States)

    Imbaud, Tamara Christine de Souza; Mallozi, Márcia Carvalho; Domingos, Vanda Beatriz Teixeira Coelho; Solé, Dirceu

    2016-01-01

    Abstract Objective: To describe the frequency and etiology of rhinitis, oral breathing, types of malocclusion and orofacial disorders in patients treated for dental malocclusion. Methods: Patients with poor dental occlusion (n=89, 8-15 years) undergoing orthodontic treatment at the Postgraduate Orthodontics Center (São Paulo, Brazil) participated in the study. Rhinitis and oral breathing were diagnosed by anamnesis, clinical assessment and allergic etiology of rhinitis through immediate hypersensitivity skin prick test with airborne allergens. The association between types of breathing (oral or nasal), rhinitis and types of dental malocclusion, bruxism and cephalometric alterations (increased Y axis of facial growth) compared to standard cephalometric tracing (Escola de Odontologia da Universidade de São Paulo) were assessed. Results: The frequency of rhinitis in patients with dental malocclusion was 76.4% (68), and, of these, 81.7% were allergic (49/60 positive skin prick test), whereas the frequency of oral breathing was 62.9%. There was a significant association between an increased Y axis of facial growth and oral breathing (p<0.001), as well as between oral breathing and rhinitis (p=0.009). There was no association between rhinitis and bruxism. Conclusions: The frequency of rhinitis in children with dental malocclusion is higher than that in the general population, which is approximately 30%. Patients with oral breathing have a tendency to a dolichofacial growth pattern (increased Y axis of facial growth). In patients with rhinitis, regardless of the presence of oral breathing, the dolichofacial growth tendency was not observed. PMID:26631324

  11. Frequency of rhinitis and orofacial disorders in patients with dental malocclusion

    Directory of Open Access Journals (Sweden)

    Tamara Christine de Souza Imbaud

    2016-06-01

    Full Text Available Abstract Objective: To describe the frequency and etiology of rhinitis, oral breathing, types of malocclusion and orofacial disorders in patients treated for dental malocclusion. Methods: Patients with poor dental occlusion (n=89, 8-15 years undergoing orthodontic treatment at the Postgraduate Orthodontics Center (São Paulo, Brazil participated in the study. Rhinitis and oral breathing were diagnosed by anamnesis, clinical assessment and allergic etiology of rhinitis through immediate hypersensitivity skin prick test with airborne allergens. The association between types of breathing (oral or nasal, rhinitis and types of dental malocclusion, bruxism and cephalometric alterations (increased Y axis of facial growth compared to standard cephalometric tracing (Escola de Odontologia da Universidade de São Paulo were assessed. Results: The frequency of rhinitis in patients with dental malocclusion was 76.4% (68, and, of these, 81.7% were allergic (49/60 positive skin prick test, whereas the frequency of oral breathing was 62.9%. There was a significant association between an increased Y axis of facial growth and oral breathing (p<0.001, as well as between oral breathing and rhinitis (p=0.009. There was no association between rhinitis and bruxism. Conclusions: The frequency of rhinitis in children with dental malocclusion is higher than that in the general population, which is approximately 30%. Patients with oral breathing have a tendency to a dolichofacial growth pattern (increased Y axis of facial growth. In patients with rhinitis, regardless of the presence of oral breathing, the dolichofacial growth tendency was not observed.

  12. Concealing Emotions at Work Is Associated with Allergic Rhinitis in Korea.

    Science.gov (United States)

    Seok, Hongdeok; Yoon, Jin-Ha; Won, Jong-Uk; Lee, Wanhyung; Lee, June-Hee; Jung, Pil Kyun; Roh, Jaehoon

    2016-01-01

    Concealing emotions at work can cause considerable psychological stress. While there is extensive research on the adverse health effects of concealing emotions and the association between allergic diseases and stress, research has not yet investigated whether concealing emotions at work is associated with allergic rhinitis. Allergic rhinitis is a common disease in many industrialized countries, and its prevalence is increasing. Thus, our aim was to determine the strength of this association using data from three years (2007-2009) of the 4th Korean National Health and Nutrition Examination Survey. Participants (aged 20-64) were 8,345 individuals who were economically active and who had completed the questionnaire items on concealing emotions at work. Odds ratio (OR) and 95% confidence intervals (95% CIs) were calculated for allergic rhinitis using logistic regression models. Among all participants, 3,140 subjects (37.6%) reported concealing their emotions at work: 1,661 men and 1,479 women. The OR (95% CIs) for allergic rhinitis among those who concealed emotions at work versus those who did not was 1.318 (1.148-1.512). Stratified by sex, the OR (95% CIs) was 1.307 (1.078-1.585) among men and 1.346 (1.105-1.639) among women. Thus, individuals who concealed their emotions at work were significantly more likely to have a diagnosis of AR in comparison to those who did not. Because concealing emotions at work has adverse health effects, labor policies that aim to reduce this practice are needed.

  13. 青岛地区变应性鼻炎患者合并哮喘的流行病学调查研究%Epidemiological Investigation of Allergic Rhinitis Patients with Asthma in Qingdao Area

    Institute of Scientific and Technical Information of China (English)

    高荣莉; 张念凯; 丁见; 臧延伟; 闫舒; 刘婷婷; 刘赞刚; 宫相贵; 周晓彬; 李娜

    2012-01-01

    目的:调查青岛地区变应性鼻炎患者合并哮喘的患病率及相关因素.方法:设计“青岛地区变应性鼻炎问卷调查表”.采用多阶段抽样及整群抽样的方法,调查青岛地区常住(5年及5年以上)居民,年龄在5-70岁,均无高血压、糖尿病、风湿性疾病及精神障碍性疾病的居民.共调查人数为2052人:调查分三个阶段:问卷调查阶段、根据问卷结果筛选AR可疑对象、对AR可疑对象进行专科检查及变应原皮肤点刺试验以确诊.对结果进行统计学处理.结果:发放问卷总数为2400份,有效问卷为2052份,有效率为85.5%,青岛地区5-70岁居民AR患者248例,其中20例合并支气管哮喘,AR患者合并哮喘的患病率为8.06%,其中男7.14%,女9.26%,男女AR患者合并哮喘的患病率差异无统计学意义(X2=0.36 P>0.05).结论:青岛地区变应性鼻炎患者合并哮喘的患病率为8.06%,初步了解青岛地区人群中变应性鼻炎合并哮喘的现状,为临床医生对其综合治疗并制定合理有效的治疗方案提供理论基础.%Objective:To investigate the morbidity of allergic rhinitis patients with asthma and correlative factors in Qingdao area.Methods:A questionnaire survey on AR in Qingdao area was designed.Two-stage sampling and cluster sampling methods were applied to the mental healthy permanent residence,excluding hypertension,diabetes mellitus and rheumatic disease,aged from 5-70 years old in Qingdao area including seven district and five cities.This investigation had three stages:questionnaire survey,screening of suspected AR patients according to the results of questionnaire,then suspects of AR were identified by the diagnose through specific examination of professional doctors and Allergen skin tests.Results:2052 questionnaires were available.The effective rate was 85.5%.There were 248 cases of AR,including 20 cases with asthma.The prevalence rate of AR patients with asthma in residents aged from 5

  14. Mechanism of traditional Chinese medicine in the treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    GUO Hong; LIU Ming-ping

    2013-01-01

    Objective To review the major progress in mechanism of traditional Chinese medicine (TCM) in the treatment of allergic rhinitis (AR).Methods Contents about the treatment mechanism of TCM in the therapy of AR in this article were obtained from 22 original articles and reviews published in Chinese-and English-language journals.All of the references were searched by use of Pubmed (1997-2012).Results AR is one of the most common and most serious public health problems in children and young people.Many AR patients were worried about the possible adverse effects of synthetic drugs they were taking.Thus,they seek complementary and alternative therapy,such as TCM.TCM emphasized on the importance of holistic convalescence,not just the disease itself.The favorable safety profile of TCM makes well-acceptance by the general population.In the recent decade,more and more studies of TCM for AR are developed.These studies indicated that the treatment of allergic disorders with TCM therapy including herbal medicines and acupuncture are of safety and efficacy.The mechanism of TCM in the treatment of AR has been discussed.It has been reported that a number of the herbs in the Chinese herbal formulae used in the treatment possess anti-allergic,anti-inflammatory or immune modulation activity.Such function include the inhibition of the release or the activity of mast cell mediators (such as histamine),inhibition the induction of inflammation reaction by chemical agents,and down regulation of serum (immunoglobulin E) IgE levels or the activity of lymphocyte and/or macrophage.Conclusions TCM are frequently used concurrently to improve the clinical efficacy.This review is focuses on the description of the actions mechanism of Chinese medicine's approach relevant to the treatment of AR.

  15. Prevalence of allergens for Changsha patients with allergic rhinitis%长沙地区变应性鼻炎患者的变应原分布特点及结果分析

    Institute of Scientific and Technical Information of China (English)

    吕云霞; 谢志海; 赵素萍; 章华; 刘永珍; 陈香; 蒋卫红

    2011-01-01

    目的:通过对长沙地区变应性鼻炎患者进行过敏原检测及分析,筛查本地区常见过敏原,绘制本地区变应性鼻炎患者的变应原分布图,为合理防治变应性鼻炎提供统计学依据.方法:对1437例疑似变应性鼻炎患者进行皮肤点刺试验,测定致敏变应原,并进行统计学分析.结果:1437例疑似变应性鼻炎患者中898例(62.49%)有阳性反应,898例阳性患者中吸入性变应原阳性率依次为粉尘螨883例(98.33%)、屋尘螨849例(94.54%)、真菌Ⅱ 173例(19.27%)和杂草165例(18.37%);食入组变应原以小虾318例(35.41%)为主;儿童期、青少年期和成年期点刺阳性患者中2种以上变应原呈阳性的比例依次为8.57%、18.04%、19.15%.结论:在长沙地区,导致变应性鼻炎的吸入性变应原中,屋尘螨、粉尘螨占据绝对的主导地位,应作为长沙地区的重点变应原开展变应性鼻炎的防治工作,尤其重视儿童变应性鼻炎的治疗.%Objective:To investigate the allergens in patients with allergic rhinitis,to find common allergens of Changsha and to provide statistic basis for a reasonable prevention and treatment. Method: The allergens in 1437 patients with allergic rhinitis in Changsha were detected by skin prick test. Result: Eight hundred and ninty eight (62.49 %)of 1 437 cases presented positive reaction. Among positive cases in inhalation group, the most common allergen was flour mite (98.33%), then were house dust mite (94. 54%), mycetes Ⅱ (19. 27%) and weed (18.37%). Shrimp(35.41%) was thc most common allergens in food group. △nd in childhood, adolescence and a dulthood prick positive cases, the ratio of more than 2 positive allergens were about 8. 57,18.04 %, 19. 15%.Conclusion:The study shows that the f1our mite and house dust mite are the most common allergens in Changsha.

  16. Loratidine buccal films for allergic rhinitis: development and evaluation.

    Science.gov (United States)

    Kumria, Rachna; Nair, Anroop B; Al-Dhubiab, Bandar E

    2014-05-01

    The objective of this study was to develop a novel patient compliant buccoadhesive film capable of providing a prolonged protection against allergic symptoms. Polymeric buccoadhesive films of loratidine were prepared using hydroxypropylmethyl cellulose (HPMC)-E5 and K100 blend and Eudragit® NE 30D as retardant. Films were prepared using solvent-casting method. The developed films were evaluated for physical properties, hydration, mucoadhesion time, drug release, etc. All the prepared films exhibited excellent mechanical strength and uniform drug content. Increase in drug content did not influence the physicomechanical properties of the film. The mucoadhesive strength of films was significantly enhanced with increase in HPMC content. Increase in Eudragit® NE 30 D content in the film decreases the hydration, erosion and drug release, but enhances the mucoadhesion time. Furthermore, the release of loratidine from the prepared films followed Hixson-Crowell kinetics. Studies in healthy human volunteers using placebo films indicate that the prepared films possess prolonged mucoadhesion in-vivo, and this could potentially lead to clinically relevant drug delivery system.

  17. Interleukin-5 and eosinophil cationic protein in nasal lavages of rhinitis patients

    NARCIS (Netherlands)

    I.M. Garrelds (Ingrid); T. De Graaf-In 't Veld (T.); M.A. Nahori (Marie Anne); B.B. Vargaftig (B.); R. Gerth van Wijk (Roy); F.J. Zijlstra (Freek)

    1995-01-01

    textabstractThe production of interleukin-5 and eosinophil cationic protein (ECP) in the nasal cavity was examined in 24 patients with rhinitis who were allergic to the house dust mite. During a double-blind placebo-controlled cross-over study, fluticasone propionate aqueous nasal spray (200 μg) was

  18. Once daily levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria

    Directory of Open Access Journals (Sweden)

    E Nettis

    2008-12-01

    Full Text Available E Nettis1, G F Calogiuri2, E Di Leo1, F Cardinale3, L Macchia1, A Ferrannini1, A Vacca1,41Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases; 24th Pneumology Department, Pneumologic Hospital A Galateo, San Cesario di Lecce, Italy; 3Department of Biomedicina dell’Età Evolutiva, Pediatrics Unit “S Maggiore”; 4Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, ItalyAbstract: Levocetirizine is the pharmacologically active enantiomer of cetirizine. It is a potent histamine H-1 receptor antagonist with anti-inflammatory and antiallergic properties. The review analyses the levocetirizine’s properties in terms of safety and efficacy both in allergic rhinitis and urticarioid syndromes.Keywords: allergic rhinitis, chronic idiopatic urticaria, levocetirizine

  19. 变应性鼻炎患者3292例变应原谱变化分析%Analysis of allergen variation for 3292 patients with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    彭晓林; 张金梅; 王丽生; 时文杰; 孙沛湧; 张玉庚; 林鹏

    2013-01-01

    Objective To investigate the variation of common allergens in patients with allergic rhinitis in recent 4 years in Tianjin First Center Hospital.Methods The medical records of skin prick test on 3292 patients with allergic rhinitis between 2009 and 2012 were restrospectively analyzed.The changing trend of various allergens in 4 years and distribution differences were compared.The differences of the top 5 allergens in under age group,adult group and different gender group were further analyzed by SPSS 19.0 software.Results The positive rate of dermatophagoides farinae was increasing year by year,from 45.1% in 2009 to 66.3% in 2012,and the positive rate of dermatophagoides pteronyssinus increased from 42.0% in 2009 to 58.6% in 2012,the difference was statistically significant (x2 value was 68.70,41.55,all P <0.01).The positive rate of dermatophagoides farinae and dermatophagoides pteronyssinus in adult group and male group showed significant upward trend year by year (x2 value was 75.85,69.93,274.25,42.62,all P <0.01),but not in adult group and female group.The positive rate of quinoa,mugwort and humulus scandens decreased year by year between 2009 and 2011 (x2 value was 22.08,11.64,203.19,all P <0.01),but increased again in 2012 (x2 value was 21.55,29.38,12.40,all P < 0.01).Conclusions There is a tendency of change of allergens in patients with AR.This phenominon may be helpful for doctors to choose the type of skin prick liquid.%目的 了解天津市第一中心医院近4年来变应性鼻炎(allergic rhinitis,AR)患者变应原谱的变化情况.方法 回顾性分析2009-2012年确诊为AR的3292例患者皮肤点刺试验结果,研究各变应原阳性率4年来的变化趋势,并进一步分析前5位变应原在未成年人组、成年人组以及不同性别组的变化情况,以SPSS 19.0软件对数据进行统计学分析.结果 粉尘螨、屋尘螨变应原阳性率呈逐年增高趋势,分别由2009年的45.1%、42.0%上升至2012

  20. Efficacy comparison of cetirizine and loratadine for allergic rhinitis in children

    Directory of Open Access Journals (Sweden)

    Juliana

    2012-03-01

    Full Text Available Background Allergic rhinitis represents a global health problem affecting 10% to more than 40% of the population worldwide. Several studies in recent years have described the efficacy of second-generation antihistamines in younger children. It is not well established whether cetirizine is more effective than loratadine in reducing symptoms of allergic rhinitis. Objective The objective of this study was to compare the efficacy of loratadine with cetirizine for treatment of allergic rhinitis. Methods We conducted a randomized, double-blind, controlled trial of 100 children, aged 13 to 16 years, from October to November 2009 at two junior high schools in Medan. Group I received 10 mg of cetirizine and group II received 10 mg of loratadine, each once daily in the morning for 14 days. Drug efficacy was assessed by changes from baseline symptom scores and evaluation of therapeutic responses after 3 days, 7 days and 14 days of treatment. Results The efficacy of cetirizine compared to that of loratadine was not statistically significant in diminishing nasal symptoms after 3 days, 7 days and 14 days of treatment (P=0.40, P=0.07, and P=0.057, respectively. Evaluation of side effects, however, revealed significantly fewer headaches in the cetirizine group after 3 days and 7 days of treatment (P=0.01 and P=0.03, respectively than in the loratidine group. In addition, the loratadine group had significantly more instances of palpitations after 7 days of treatment (P=0.04 compared to the cetirizine group. Conclusion There was no significant difference in cetirizine and loratadine treatment effectiveness on allergic rhinitis. However, loratadine was found to cause more headaches and palpitations than cetirizine. [Paediatr Indones. 2012;52:61-6].

  1. Prevalence of allergic rhinitis in Filipino adults based on the National Nutrition and Health Survey 2008

    Science.gov (United States)

    Kwong, Shirley L.; Alava, Hilda Diana A.; Castor, Mary Anne R.; De Leon, Julia C.

    2012-01-01

    Background There has been no documented data on the prevalence of allergic rhinitis among Filipino adults. Objective The objective of this study is to determine the prevalence of allergic rhinitis among adults in the Philippines. Methods Using a multi-staged cluster sampling methodology, this study evaluated 7,202 adults from 3,744 households, 79 provinces and 17 regions. A pre-validated written questionnaire for allergic rhinitis based on the International Study of Asthma and Allergies of Childhood was used as the survey instrument. Results The response rate obtained from the interview was 94.1%. The overall prevalence of nose symptoms in the past 12 months was 20% while prevalence of nose symptoms at any time in the past was 23.8%. The proportion among both sexes was similar. The prevalence was highest among the respondents 40-49 years old. The overall prevalence of nose and eye symptoms for the past twelve months was 14.0%. The prevalence of respondents who reported presence of nose problems for the past twelve months was similar across the 12 months of the year with highest rates noted in the months of June and May. Respondents from the rural area (22.1%) reported a higher prevalence of nose symptoms for the past twelve months compared to respondents from urban area (18%). There was no significant difference in prevalence of nose symptoms among residents living in coastal and/or inland areas. Conclusion The overall prevalence of allergic rhinitis in the Philippines based on the 2008 National Nutrition and Health Survey is 20.0%. PMID:22701863

  2. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis.

    Science.gov (United States)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W; Arnavielhe, Sylvie; Bachert, Claus; Bedbrook, Anna; Bergmann, Karl-Christian; Bosnic-Anticevich, Sinthia; Brozek, Jan; Calderon, Moises; Canonica, G Walter; Casale, Thomas B; Chavannes, Niels H; Cox, Linda; Chrystyn, Henry; Cruz, Alvaro A; Dahl, Ronald; De Carlo, Giuseppe; Demoly, Pascal; Devillier, Phillipe; Dray, Gérard; Fletcher, Monica; Fokkens, Wytske J; Fonseca, Joao; Gonzalez-Diaz, Sandra N; Grouse, Lawrence; Keil, Thomas; Kuna, Piotr; Larenas-Linnemann, Désirée; Lodrup Carlsen, Karin C; Meltzer, Eli O; Mullol, Jaoquim; Muraro, Antonella; Naclerio, Robert N; Palkonen, Susanna; Papadopoulos, Nikolaos G; Passalacqua, Giovanni; Price, David; Ryan, Dermot; Samolinski, Boleslaw; Scadding, Glenis K; Sheikh, Aziz; Spertini, François; Valiulis, Arunas; Valovirta, Erkka; Walker, Samantha; Wickman, Magnus; Yorgancioglu, Arzu; Haahtela, Tari; Zuberbier, Torsten

    2016-08-01

    The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials.

  3. Allergic rhinitis and asthma: inflammation in a one-airway condition

    Directory of Open Access Journals (Sweden)

    Haahtela Tari

    2006-11-01

    Full Text Available Abstract Background Allergic rhinitis and asthma are conditions of airway inflammation that often coexist. Discussion In susceptible individuals, exposure of the nose and lungs to allergen elicits early phase and late phase responses. Contact with antigen by mast cells results in their degranulation, the release of selected mediators, and the subsequent recruitment of other inflammatory cell phenotypes. Additional proinflammatory mediators are released, including histamine, prostaglandins, cysteinyl leukotrienes, proteases, and a variety of cytokines, chemokines, and growth factors. Nasal biopsies in allergic rhinitis demonstrate accumulations of mast cells, eosinophils, and basophils in the epithelium and accumulations of eosinophils in the deeper subepithelium (that is, lamina propria. Examination of bronchial tissue, even in mild asthma, shows lymphocytic inflammation enriched by eosinophils. In severe asthma, the predominant pattern of inflammation changes, with increases in the numbers of neutrophils and, in many, an extension of the changes to involve smaller airways (that is, bronchioli. Structural alterations (that is, remodeling of bronchi in mild asthma include epithelial fragility and thickening of its reticular basement membrane. With increasing severity of asthma there may be increases in airway smooth muscle mass, vascularity, interstitial collagen, and mucus-secreting glands. Remodeling in the nose is less extensive than that of the lower airways, but the epithelial reticular basement membrane may be slightly but significantly thickened. Conclusion Inflammation is a key feature of both allergic rhinitis and asthma. There are therefore potential benefits for application of anti-inflammatory strategies that target both these anatomic sites.

  4. 变应原疫苗免疫治疗对过敏性支气管哮喘合并鼻炎的疗效分析%Effect of allergen immunotherapy with standardized vaccine in patients with allergic asthma and rhinitis

    Institute of Scientific and Technical Information of China (English)

    孙立英; 郭胤仕; 王菁兰; 王群; 王怡玮; 许以平

    2011-01-01

    目的 评估标准化变应原疫苗免疫治疗(allergen immunotherapy,AIT)对过敏性哮喘合并鼻炎患者的近期疗效.方法设计调查问卷,对我院门诊接受标准化变应原疫苗-安脱达(Alutard(R)SQ)AIT治疗的39例过敏性哮喘合并鼻炎患者进行问卷调查,应用哮喘控制水平分级和哮喘控制测试(ACT)评分评价哮喘的疾病控制水平,应用鼻炎病情评分(RCT)评价过敏性鼻炎的控制情况.结果39例患者治疗前后的哮喘控制水平分级(Z=-7.235,P<0.05)、ACT评分(t=16.533,P<0.05)、RCT评分(t=16.650,P<0.05),情绪(x2=34.873,P<0.05)等均有较大程度的改善.结论标准化AIT治疗能明显改善过敏性哮喘合并鼻炎患者的临床症状.%Objective We sought to assess the effect of allergen immunotherapy (AIT) with Alutard? SQ in patients with allergic asthma and rhinitis. Methods Designed the questionnaire and surveyed 39 patients with allergic asthma and rhinitis accepting AIT with Alutard? SQ allergen extract so that we can know their situation before and after accepting AIT. We used levels of asthma control and Asthma Control Test(ACT)to evaluate their levels of asthma control, and used Rhinitis condition score (RCT) to evaluated their rhinitis control. Results 39 subjects completed the survey, and the results showed: AIT resulted in a significant improvement in levels of asthma control( Z = - 7. 235, P <0. 05), ACT (t =16.533, P <0. 05), RCT (t =16.650, P <0. 05) and mood(x2= 34. 873, P <0. 05). Conclusions AIT with Alutard? SQ significantly improved symptoms of the patients with allergic asthma and rhinitis.

  5. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet

    DEFF Research Database (Denmark)

    Demoly, Pascal; Emminger, Waltraud; Rehm, Dorte

    2016-01-01

    BACKGROUND: The SQ HDM SLIT-tablet (ALK) has been developed for treatment of house dust mite (HDM)-induced respiratory allergic disease. OBJECTIVE: This trial investigated the efficacy and safety of the SQ HDM SLIT-tablet in adults with moderate-to-severe HDM-induced allergic rhinitis (AR). METHODS...

  6. Rhinitis symptoms and IgE sensitization as risk factors for development of later allergic rhinitis in adults

    DEFF Research Database (Denmark)

    Bodtger, U; Poulsen, Lars K.; Linneberg, A

    2006-01-01

    Rhinitis symptoms and IgE-sensitization often mismatch. Asymptomatic sensitization is an established risk factor for later rhinitis, whereas it is not clear whether rhinitis is a risk factor for later development of IgE-sensitization.......Rhinitis symptoms and IgE-sensitization often mismatch. Asymptomatic sensitization is an established risk factor for later rhinitis, whereas it is not clear whether rhinitis is a risk factor for later development of IgE-sensitization....

  7. Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments

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    Gesmar RS Segundo

    2009-10-01

    Full Text Available Gesmar RS Segundo1, Fabíola A Gomes2, Karla P Fernandes1, Ronaldo Alves3, Deise AO Silva3, Ernesto A Taketomi31Department of Pediatrics, 2Department of Nursery, 3Laboratory of Allergy and Clinical Immunology, Universidade Federal de Uberlandia, Uberlandia, BrazilBackground: Therapy for allergic rhinitis aims to control symptoms and improve the quality of life. The treatment of allergic rhinitis includes allergen avoidance, environmental controls, pharmacologic treatment, and specific immunotherapy.Objectives: The aim of this study is to evaluate the clinical changes and the levels of interferon-γ (IFN-γ and interleukin-5 (IL-5 in nasal lavage fluid from children with allergic rhinitis after different types of pharmacologic treatment (mometasone, montelukast, or desloratadine.Methods: Twenty-four children aged from six to 12 years with moderate persistent allergic rhinitis were randomized into three groups receiving monotherapy treatment over four weeks: nasal corticosteroid (mometasone, leukotriene modifier (montelukast, or antihistamine (desloratadine. The perception of symptom improvement during the medication use was evaluated at the end of the treatment. Samples of nasal lavage fluid were collected before and after treatment for measuring IFN-γ and IL-5 cytokines by ELISA.Results: All parents perceived an improvement in symptoms. Significant enhancement was seen in the mometasone group compared to those with montelukast (P = 0.01 and desloratadine (P = 0.02. No significant differences were found among the three groups in the levels of IL-5 and IFN-γ in nasal fluid at baseline or after treatment. Only the group treated with mometasone showed a slight but significant reduction in IL-5 levels after the treatment period as compared with levels before the treatment (P = 0.0469.Conclusion: The group treated with mometasone showed better improvement of clinical symptoms and a slight reduction in IL-5 levels in the nasal fluid. This may

  8. Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis

    Science.gov (United States)

    Günel, Ceren; Demirci, Buket; Eryılmaz, Aylin; Yılmaz, Mustafa; Meteoğlu, İbrahim; Ömürlü, İmran Kurt; Başal, Yeşim

    2016-01-01

    Background The supplement Pycnogenol® (PYC) has been used for the treatment of several chronic diseases including allergic rhinitis (AR). However, the in vivo effects on allergic inflammation have not been identified to date. Aims To investigate the treatment results of PYC on allergic inflammation in a rat model of allergic rhinitis. Study Design Animal experimentation. Methods Allergic rhinitis was stimulated in 42 rats by intraperitoneal sensitization and intranasal challenge with Ovalbumin. The animals were divided into six subgroups: healthy controls, AR group, AR group treated with corticosteroid (dexamethasone 1 mg/kg; CS+AR), healthy rats group that were given only PYC of 10 mg/kg (PYC10), AR group treated with PYC of 3mg/kg (PYC3+AR), and AR group treated with PYC of 10 mg/kg (PYC10+AR). Interferon-γ (IFN-γ), interleukin-4 (IL-4), interleukin-10 (IL-10), and OVA-specific immunoglobulin E (Ig-E) levels of serum were measured. Histopathological changes in nasal mucosa and expression of tumor necrosis factor-α (TNF-α) and IL-1β were evaluated. Results The levels of the IL-4 were significantly decreased in the PYC3+AR, PYC10+AR and CS+AR groups compared with the AR group (p=0.002, p<0.001, p=0.006). The production of the IFN-γ was significantly decreased in the PYC3+AR and PYC10+AR groups compared with the AR group (p=0.013, p=0.001). The administration of PYC to allergic rats suppressed the elevated IL-10 production, especially in the PYC3+AR group (p=0.006). Mucosal edema was significantly decreased respectively after treatment at dose 3 mg/kg and 10 mg/kg PYC (both, p<0.001). The mucosal expression of TNF-α has significantly decreased in the PYC3+AR and PYC10+AR groups (p=0.005, p<0.001), while the IL-1β expression significantly decreased in the CS+AR, PYC3+AR, and PYC10+AR groups (p<0.001, p=0.003, p=0.001). Conclusion PYC has multiple suppressive effects on allergic response. Thus, PYC may be used as a supplementary agent in allergic response

  9. Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray

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    Nina Werkhäuser

    2014-01-01

    Full Text Available Objectives. Allergic rhinitis is a common disease with increasing prevalence and high impact on economic burden and comorbidities. As treatment with pharmacological drugs is not always satisfactory due to side effects and incomplete efficacy, alternative treatment strategies are needed. Ectoine is an osmolyte with membrane stabilizing and inflammation reducing capacities. Nasal spray and eye drops containing ectoine are promising new treatment regimens for allergic rhinitis sufferers. Design and Methods. The current two noninterventional trials evaluated the efficacy and safety of ectoine containing nasal spray and eye drops for treating allergic rhinitis in comparison with either azelastine or cromoglycic acid containing products. Nasal and ocular symptom developments as well as judgment of tolerability and efficacy were assessed both by investigators and patients over a time period of one to two weeks. Results. Both trials confirmed that ectoine containing products reduced nasal and ocular symptoms in allergic rhinitis patients. Results clearly demonstrated good safety profiles of the ectoine products comparable to those of azelastine and even better to those of cromoglycate products. Conclusion. Ectoine containing nasal spray and eye drops are interesting new treatment strategies for sufferers of allergic rhinitis, combining both good efficacy and absence of side effects.

  10. Treatment of allergic rhinitis with ectoine containing nasal spray and eye drops in comparison with azelastine containing nasal spray and eye drops or with cromoglycic Acid containing nasal spray.

    Science.gov (United States)

    Werkhäuser, Nina; Bilstein, Andreas; Sonnemann, Uwe

    2014-01-01

    Objectives. Allergic rhinitis is a common disease with increasing prevalence and high impact on economic burden and comorbidities. As treatment with pharmacological drugs is not always satisfactory due to side effects and incomplete efficacy, alternative treatment strategies are needed. Ectoine is an osmolyte with membrane stabilizing and inflammation reducing capacities. Nasal spray and eye drops containing ectoine are promising new treatment regimens for allergic rhinitis sufferers. Design and Methods. The current two noninterventional trials evaluated the efficacy and safety of ectoine containing nasal spray and eye drops for treating allergic rhinitis in comparison with either azelastine or cromoglycic acid containing products. Nasal and ocular symptom developments as well as judgment of tolerability and efficacy were assessed both by investigators and patients over a time period of one to two weeks. Results. Both trials confirmed that ectoine containing products reduced nasal and ocular symptoms in allergic rhinitis patients. Results clearly demonstrated good safety profiles of the ectoine products comparable to those of azelastine and even better to those of cromoglycate products. Conclusion. Ectoine containing nasal spray and eye drops are interesting new treatment strategies for sufferers of allergic rhinitis, combining both good efficacy and absence of side effects.

  11. CLINICAL INVESTIGATIONS ON THE AYURVEDIC MANAGEMENT OF ALLERGIC RHINITIS (VATAJA PRATISHYAYA BY PRATIMARSHA NASYAAS NASAL DRUG DELIVERY SYSTEM.

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    Shiva Kumar

    2014-12-01

    Full Text Available Allergic Rhinitis (AR is an immunoglobulin (Ig E mediated inflammatory disease caused by the inflammation of airway mucosa with hypersensitivity resulting from seasonal or perennial responses to specific allergens. Prevalence of AR is increasing and has risen considerably in the past few decades with self reported prevalence up to 41%. According to Ayurvedic texts indication of Anutaila (classical Ayurvedic oil preparation used in the form of Pratimarsha Nasya a traditional nasal drug delivery system has been used for a long period has shown beneficial effects on diseases of head and neck. A pretest and post test design of single group consisting of 37 patientsdiagnosed as allergic rhinitis were administered Pratimarsha Nasya (PNwith Anutaila daily for a period of 60 days. Effect ofPratimarsha Nasya with Anutaila on the chief complaints and totals nasal symptom score showed ameliorative improvement with statistical significance. Laboratory immunological parameters which included Total Leucocyte Count, Absolute Eosinophil Count, Neutrophils and Lymphocytes showed improvement with high statistical significance (< 0.001. At the end after 60 days of medication the patients showed marked relief in symptoms which can open a new direction in Ayurveda inspired novel targeted drug delivery systems.

  12. Evaluation of Prevalence of Allergic Rhinitis Symptoms in Kurdistan, a Western Province in Iran

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    Rasoul Nasiri

    2015-11-01

    Full Text Available Introduction Allergic rhinitis, like other allergic diseases, is one of the most common disorders during childhood; this study was conducted to assess and compare the prevalence and severity of allergic rhinitis in children and adolescents living in Kurdistan province. The study was aimed to provide a ground for the identification of likely causes and risk factors of this disorder. Materials and Methods This study was a cross-sectional study. In order to collect data, 4,000 questionnaires were distributed to elementary schools and junior high schools and 3,890 questionnaires were completed; as a result, the survey response rate was 97%. The study was carried out based on International Study of Asthma and Allergies in Childhood (ISAAC: ISAAC questionnaire. After entering the data into SPSS version 13, they were analyzed using logistic regression and Chi- square test. Results Of a total 3,890 people, 29.7% of the subjects in this study reported a history of sneezing or runny nose in the past 12 months; it was reported more in boys in the age group 13-14 years and the difference between the sexes was significant [Odds ratio(OR=1.35, Confidence interval (CI]: 1.09-1.67, P < 0.01. Based on physician diagnosis, 9.37% of the subjects were overtaken by allergic rhinitis and it was more prevalent in boys at both educational levels and the difference was statistically significant in subjects aged 13-14 years old (OR=1.44 CI: 1.07-1.94, P

  13. Psychological characteristics in patients with allergic rhinitis and its associated factors analysis%变应性鼻炎患者的心理学特点及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    锡琳; 韩德民; 吕晓飞; 张罗

    2009-01-01

    Objective To investigate the psychological characteristics of patients with allergic rhinitis(AR)and its associated factors.Methods Three hundred and seventy-seven patients with AR were evaluated by the Symptom Checklist-90(SCL-90).The results were compared with a standard,obtained from healthy Chinese population,including factors of gender,age,educational level,medical history of AR,presence of complications,type of allergenic sensitizations and nasal symptoms(using logistic regression analysis).Results An abnormal psychological state was found in 10% of AR patients,13% with deutohealthy,and remaining 77% of AR patients were completely healthy.The SCL-90 scores of the 377 patients were significantly higher than those of the normal standard population,including symptoms of somatization,compulsion,anxiety,rivalry and psychosis(t equals 7.128,3.943,2.777,6.423,7.507,respectively,all P<0.01).Male patients had worse psychological state than femals,especially in the aspects of compulsion,depression,anxiety,crankiness and psychosis(t equals respectively 2.680,1.977,2.539,2.107,2.844,all P<0.05).The SCL-90 scores of compulsion and horror were respectively different in different AR case history(F equals respectively 2.379,2.255,all P<0.05).AR complicated with asthma and eczema was the important factors that influenced patient's psychological status including compulsion,interpersonal sensitivity,depression,crankiness and psychosis(t equals respectively 6.835,8.914,7.254,13.358,6.030,all P<0.01).There were no statistical differences in different ages,AR types,educational level,allergen types(all P>0.05).Snuffle,sneeze and snivel had no influence on patient's SCL-90 scores(all P>0.05).Itchy nose was a major symptom that affect on AR patients' SCL-90 scores of depression(standard regression b=0.126,t=2.076,P<0.05).Conclusions AR patients' psychological status was worse than that of the healthy adults.%目的 观察变应性鼻炎(allergic rhinitis,AR)患者的

  14. Allergic disease as an association of steroid sulphatase deficiency.

    Science.gov (United States)

    Sakura, N; Nishimura, S; Matsumoto, T; Ohsaki, M; Ogata, T

    1997-11-01

    Ten of 31 patients with steroid sulphatase (STS) deficiency were found to have an allergic disease (bronchial asthma, allergic rhinitis, or atopic dermatitis). STS deficiency may predispose patients to allergic disease.

  15. Co-Administration of Chenopodium Album Allergens and CpG Oligodeoxy-nucleotides Effects on Peripheral Blood Mononuclear Cells of Patients with Allergic Rhinitis Treated with Intranasal Corticosteroids

    Directory of Open Access Journals (Sweden)

    Shokrollah Farrokhi

    2011-06-01

    Full Text Available Allergic Rhinitis (AR is one of the most common chronic diseases in the developed countries. This study was performed to investigate the effect of CpG-ODN in alteration of T-helper (Th1/Th2 balance of patients with AR treated with intranasal corticosteroids (INCs and antihistamines. Peripheral blood mononuclear cells (PBMCs of 20 patients with AR were isolated before and after 45 days therapy.Cytokine production (IL-4, IL-10, IL-13, IFN-γ and specific Ch.a IgE in response to CpG co- administration  of  natural  chenopodium  album  (CpG/Ch.a  or  recombinant  Ch.a  (CpG/rCh.a allergen were investigated in supernatants.of cultured PBMCs using ELISA Intracellular IL-10 was also assessed in CD4+ cells using flow cytometry. Significant increase in production of IFN-γ and IL-10 and decrease in production of IL-4 were found in supernatants of cultured PBMCs activated with CPG/ch.a and CPG/rch.a. of both CpG/Ch.a and CpG/rCh.a compared to allergens alone, before and after therapy.After therapy, IFN-γ production with CpG/Ch.a was significantly increased in comparison with before (237 vs. 44 pg/ml, p=0.001. IFN-γ and IL-10 production with CpG/rCh.a was significantly increased after therapy compared to before (407.6 vs. 109 pg/ml, p=0.01 for IFN-γ; 171.7 vs. 52.6 pg/ml, p=0.008  for  IL-10,  whilst  IL-4  was  significantly decreased (2.1  vs.  5.8  pg/ml,  p=0.02. Intracellular IL-10 expression was also significantly increased in response to either CpG/Ch.a or CpG/rCh.a that showed intracellular assay could be more sensitive than ELISA. Also, treatment with intranasal corticosteroids and antihistamines could enhance this CpG effect, in vitro.

  16. A survey of the burden of allergic rhinitis in Hungary from a specialist’s perspective

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    Szilasi Mária

    2012-11-01

    Full Text Available Abstract Background The casual and severity distribution of allergic rhinitis (AR in Hungary is unknown. The aim of this survey was to evaluate symptom perception, disease severity, concomitant asthma frequency and the impact of AR on everyday life activities in a cross-sectional, multicenter study in Hungary under the supervision of Hungarian Respiratory Society. Methods Data were recorded by 933 AR patients (65.93% women and their treating specialists. The perceptions of patients regarding the symptoms (nasal, ocular and others of AR and its severity, together with its impact on everyday life were assessed. Physicians recorded data regarding the diagnosis and severity of AR, and comorbidities. Results 52.5% of patients suffered from seasonal AR, 35.1% from perennial AR. A large proportion of patients had moderate to severe disease (MS-AR (57.34%, persistent disease (98.0% and concomitant asthma (53.32% in the mild, 57.52% in the MS-AR group. MS-AR was more frequent among women. Despite the treatment used, in MS-AR the proportions of patients reporting moderate to severe rhinorrhoea, nasal obstruction, ocular itching/redness, watering, itchy throat and sneezing were as high as 52.0%, 54.0%, 33.8%, 26.5%, 44.0% and 31.2%, respectively. Overall, there was a poor agreement between disease severity reported by patients and specialists. The adherence to oral antihistamines and intranasal corticosteroids was found to be between 50 and 65%; mostly depending on the dosage form. Conclusions AR remains a significant health problem in Hungary because of the burden of symptoms, high rate of concomitant asthma and the significant proportion of MS-AR affecting general well being.

  17. Efficacy of Sublingual Swallow Immunotherapy in Children with Rye Grass Pollen Allergic Rhinitis: A Double-blind Placebo-Controlled Study

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    Akefeh Ahmadiafshar

    2012-06-01

    Full Text Available Specific local immunotherapy has been recently introduced as an alternative to classic subcutaneous immunotherapy in treatment of allergic rhinitis. In this study, the effects of sublingual immunotherapy (SLIT on symptoms and medication score and skin prick test evaluation of patients with allergic rhinitis were investigated.In this placebo controlled trial, twenty four patients aged 5-18 years old with grass pollen induced rhinitis and sensitive to  rye grass by positive skin prick test received randomly sublingual extract of rye grass or placebo for 6 months. Symptom and medication scores and adverse effects of SLIT were assessed during treatment. Skin prick test induced wheal at the beginning and  the  end  of  therapy were also measured. Data  were analyzed with SPSS software.We found significant reduction of symptoms in intervention group from 21st  week of immunotherapy (p<0.05. Medication scores were also reduced after 16th  week (p<0.05, adverse effects were low and insignificant in both groups. Erythema induced diameter with skin  prick  test  for  grass  and  rye  grass  was  significantly reduced  in  SLI  group  after immunotherapy.This study indicates that SLIT in grass-pollen rhinitis is well tolerated, improves overall clinical symptoms,  and  reduces drug consumes.  We recommend  this  therapy as a safe therapy in patients with allergic rhinitis.

  18. Management of allergic and non-allergic rhinitis: a primary care summary of the BSACI guideline.

    Science.gov (United States)

    Angier, Elizabeth; Willington, Jenny; Scadding, Glenis; Holmes, Steve; Walker, Samantha

    2010-09-01

    Rhinitis is a common problem in primary care which is often managed sub-optimally. It causes considerable morbidity and has been shown to have a detrimental impact on people's ability to concentrate at school and at work. Rhinitis and asthma often present together, and symptomatic rhinitis can be associated with poor asthma control and increased risk of exacerbations. There is therefore a clear need to recognise and treat rhinitis according to guideline recommendations. This article is a primary care summary of the British Society for Allergy & Clinical Immunology (BSACI) Standards of Care Committee guideline on the management of rhinitis, written by a multi-disciplinary group of clinicians. It takes into account the time restrictions on assessment and the tests and equipment available in primary care, as well as the need for practical, clear and intuitive strategies for investigation and management. It recommends a stepwise approach to treatment, and highlights the relevance of less frequently prescribed treatments, including nasal douching leukotriene receptor antagonists and anticholinergics. Red flag symptoms are identified, together with indicators for referral. As with many other long term conditions, good communication between primary and secondary care in terms of timely and appropriate referral is a key factor for success.

  19. Factors confusing the diagnosis of laryngopharyngeal reflux: the role of allergic rhinitis and inter-rater variability of laryngeal findings.

    Science.gov (United States)

    Eren, Erdem; Arslanoğlu, Seçil; Aktaş, Ayşe; Kopar, Aylin; Ciğer, Ejder; Önal, Kazım; Katılmiş, Hüseyin

    2014-04-01

    The objective of the study was to determine the inter-rater variability in assessment of laryngeal findings and whether diagnosing laryngopharyngeal reflux based on the laryngeal findings and history alone without considering allergic rhinitis leads to the overdiagnosis and overtreatment of laryngopharyngeal reflux. Patients with positive and negative skin prick tests were recruited from an allergy clinic in a tertiary teaching university hospital. All subjects completed the Reflux Symptom Index (RSI) and underwent laryngeal examinations by three physicians blinded to the skin prick test results and the Reflux Finding Score (RFS) was determined. RFS >7 or RSI >13 was considered reflux positive. Fleiss' kappa (κ) was used to measure inter-rater agreement. The inter-rater agreement was low for pseudosulcus vocalis (κ = 0.078), ventricular obliteration (κ = 0.206), diffuse laryngeal edema (κ = 0.204), and posterior laryngeal hypertrophy (κ = 0.27), intermediate for laryngeal erythema/hyperemia (κ = 0.42) and vocal fold edema (κ = 0.42), and high for thick endolaryngeal mucus (κ = 0.61). Although the frequency of allergy was high, there was no significant difference between allergy-positive and laryngopharyngeal reflux-positive patients. On logistic regression analysis, thick endolaryngeal mucus was a significant predictor of allergy (p = 0.012, odds ratio 0.264, 95 % confidence interval 0.093-0.74). The laryngeal examination for reflux is subject to marked inter-rater variability and allergic laryngitis was not misdiagnosed as laryngopharyngeal reflux. The presence of thick endolaryngeal mucus should alert physicians to the possibility of allergic rhinitis/laryngitis.

  20. Suppression of Immunotherapy on Group 2 Innate Lymphoid Cells in Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    Da-Chuan Fan; Xiang-Dong Wang; Cheng-Shuo Wang; Yang Wang; Fei-Fei Cao; Luo Zhang

    2016-01-01

    Background:Group 2 innate lymphoid cells (ILC2s) are regarded as a novel population of lineage-negative cells that induce innate Type 2 responses by producing the critical Th2-type cytokines interleukin (IL)-5 and IL-13.ILC2s as key players in the development of allergic rhinitis (AR) have been proved,however,the effect of subcutaneous immunotherapy (SCIT) with dermatophagoides pteronyssinus extract (Der p-SCIT) on ILC2s in AR patients is not clear.This study aimed to investigate the response of ILC2s of peripheral blood in house dust mites (HDM)-sensitized Chinese patients with AR who received SCIT with Der P extract.Methods:Seven healthy controls without symptoms of AR who had negative reactions to any of the allergens from skin-prick testing,nine patients diagnosed with persistent AR according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines,and 24 AR patients who received Der p-SCIT for 1.0-3.5 years were recruited for the study.ILC2s in the peripheral blood were evaluated using flow cytometry.The severity of their symptoms of all participants was rated based on the Total 5 symptom score.Results:Among 40 participants,9 AR patients were assigned to the untreated group,24 AR patients receiving Der p-SCIT were assigned to the immunotherapy group,and 7 healthy controls without symptoms of AR were assigned to healthy control group.The mean Total 5 symptom score of immunotherapy group was significantly lower than that of untreated group (4.3 ± 1.4 vs.10.1 ± 2.5,P < 0.001).Similarly,the levels of ILC2s in the peripheral blood of immunotherapy group were significantly reduced compared with that in untreated group (P < 0.001),but were not significantly different from healthy controls (P =0.775).Further subgroup analysis based on the duration of SCIT therapy (1.0-2.0 years [SCIT1-2],2.0-3.0 years [SCIT2-3],and 3.0-3.5 years [SCIT3-3.5]) showed that the percentage of ILC2s was not significantly different between SCIT1-2,SCIT2-3,and SCIT3

  1. Variation in Uteroglobin-Related Protein 1 (UGRP1 gene is associated with Allergic Rhinitis in Singapore Chinese

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    Wang De Yun

    2011-03-01

    Full Text Available Abstract Background Uteroglobin-Related Protein 1 (UGRP1 is a secretoglobulin protein which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 has also been shown to be an important pneumoprotein, with diagnostic potential as a biomarker of lung damage. Previous genetic studies evaluating the association between variations on UGRP1 and allergic phenotypes have yielded mixed results. The aim of this present study was to identify genetic polymorphisms in UGRP1 and investigate if they were associated with asthma and allergic rhinitis in the Singapore Chinese population. Methods Resequencing of the UGRP1 gene was conducted on 40 randomly selected individuals from Singapore of ethnic Chinese origin. The polymorphisms identified were then tagged and genotyped in a population of 1893 Singapore Chinese individuals. Genetic associations were evaluated in this population comparing 795 individuals with allergic rhinitis, 718 with asthma (of which 337 had both asthma and allergic rhinitis and 717 healthy controls with no history of allergy or allergic diseases. Results By resequencing the UGRP1 gene within our population, we identified 11 novel and 16 known single nucleotide polymorphisms (SNPs. TagSNPs were then genotyped, revealing a significant association between rs7726552 and allergic rhinitis (Odds Ratio: 0.81, 95% Confidence Interval: 0.66-0.98, P = 0.039. This association remained statistically significant when it was analyzed genotypically or when stratified according to haplotypes. When variations on UGRP1 were evaluated against asthma, no association was observed. Conclusion This study documents the association between polymorphisms in UGRP1 and allergic rhinitis, suggesting a potential role in its pathogenesis.

  2. Association between allergic rhinitis, bottle feeding, non‐nutritive sucking habits, and malocclusion in the primary dentition

    Science.gov (United States)

    Vázquez‐Nava, F; Quezada‐Castillo, J A; Oviedo‐Treviño, S; Saldivar‐González, A H; Sánchez‐Nuncio, H R; Beltrán‐Guzmán, F J; Vázquez‐Rodríguez, E M

    2006-01-01

    Aim To determine the association between allergic rhinitis, bottle feeding, non‐nutritive sucking habits, and malocclusion in the primary dentition. Methods Data were collected on 1160 children aged 4–5 years, who had been longitudinally followed since the age of 4 months, when they were admitted to nurseries in a suburban area of Tampico–Madero, Mexico. Periodically, physical examinations were conducted and a questionnaire was given to their parents or tutors. Results Malocclusion was detected in 640 of the children (51.03% had anterior open bite and 7.5% had posterior cross‐bite). Allergic rhinitis alone (adjusted odds ratio = 2.87; 95% CI 1.57 to 5.25) or together with non‐nutritive sucking habits (adjusted odds ratio = 3.31; 95% CI 1.55 to 7.09) had an effect on anterior open bite. Bottle feeding alone (adjusted odds ratio = 1.95; 95% CI 1.07 to 3.54) or together with allergic rhinitis (adjusted odds ratio = 3.96; 95% CI 1.80 to 8.74) had an effect on posterior cross‐bite. Posterior cross‐bite was more frequent in children with allergic rhinitis and non‐nutritive sucking habits (10.4%). Conclusions Allergic rhinitis alone or together with non‐nutritive sucking habits is related to anterior open bite. Non‐nutritive sucking habits together with allergic rhinitis seem to be the most important factor for development of posterior open bite in children under the age of 5 years. PMID:16769710

  3. PRIMARY NOCTURNAL ENURESIS IN CHILDREN WITH ALLERGIC RHINITIS AND SEVERE ADENOTONSILLAR HYPERTROPHY: A SINGLE CENTER PILOT STUDY.

    Science.gov (United States)

    Chimenz, R; Manti, S; Fede, C; Stroscio, G; Visalli, C; Nicotera, A; Di Rosa, G; Romeo, A C; Salpietro, V; Cuppari, C

    2015-01-01

    Nocturnal enuresis is defined as intermittent urinary incontinence during sleep that occurs at least twice a week for three consecutive months. There is no unifying etiology for nocturnal enuresis in the pediatric population and the disorder is likely to be multifactorial. We aimed to investigate the relationship between primary nocturnal enuresis, allergic rhinitis, and related complications in a paediatric case series from a single Center. We retrospectively reviewed and prospectively followed-up at our Institution (i) 32 children (14 females, 18 males; mean age 6.31±1.21 yrs) affected by allergic rhinitis with adenoidal hypertrophygrade I-II (group A) and (ii) 27 children (11 females, 16 males; mean age 6.52±1.33 yrs) affected by allergic rhinitis with adenoidal hypertrophy grade III-IV (group B). Allergic rhinitis was diagnosed on the basis of (a) typical nasal symptoms due to atopic sensitization (e.g., rhinorrhea , itching, sneezing fits, and nasal congestion and obstruction) and (b) positive skin prick testing and/or increased level of total serum IgE. We identified discrepancies between group A and group B in terms of risk of primary nocturnal enuresis. In fact, only 1 child of group A (3.12%) reported uncomplicated primary nocturnal enuresis; conversely, 6 children of group B (22.22%) showed a history of uncomplicated primary nocturnal enuresis (p=0.040). There was no statistically significant difference between the two groups in terms of atopic sensitization and serum total IgE levels (p=0.43). Allergic rhinitis may potentially influence the onset and the natural history of nocturnal enuresis in some children. Children with allergic rhinitis and more severe respiratory manifestations, seem to be more prone to developing primary nocturnal enuresis, likely due to potential multi-factorial causes (e.g., sleep disorders, chronic phlogosis, immune deregulation).

  4. A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe

    Science.gov (United States)

    Christensen, Stine Holmegaard; Timm, Signe; Janson, Christer; Benediktsdóttir, Bryndis; Forsberg, Bertil; Holm, Mathias; Jogi, Rain; Johannessen, Ane; Omenaas, Ernst; Sigsgaard, Torben; Svanes, Cecilie; Schlünssen, Vivi

    2016-01-01

    Background The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood. Methods The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 1945–1973. This paper analyses 13,376 participants of the third study wave. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models. Results Livestock farm upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.54–0.85] and nasal symptoms (OR 0.82, 0.68–0.99) than city upbringing, and an urban–rural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.88–0.94). Pets in the home at birth (OR 0.78, 0.68–0.88) and during childhood (OR 0.83, 0.74–0.93) were associated with less subsequent allergic rhinitis. Pet keeping did not explain the protective effect of place of upbringing. Conclusion Risk of allergic rhinitis and nasal symptoms in adulthood was inversely associated with the level of urbanisation during upbringing. Pets at birth decreased the risk further, but did not explain the urban–rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findings. PMID:27890047

  5. The Association between Ambient Air Pollution and Allergic Rhinitis: Further Epidemiological Evidence from Changchun, Northeastern China

    Science.gov (United States)

    Teng, Bo; Zhang, Xuelei; Yi, Chunhui; Zhang, Yan; Ye, Shufeng; Wang, Yafang; Tong, Daniel Q.; Lu, Binfeng

    2017-01-01

    With the continuous rapid urbanization process over the last three decades, outdoors air pollution has become a progressively more serious public health hazard in China. To investigate the possible associations, lag effects and seasonal differences of urban air quality on respiratory health (allergic rhinitis) in Changchun, a city in Northeastern China, we carried out a time-series analysis of the incidents of allergic rhinitis (AR) from 2013 to 2015. Environmental monitoring showed that PM2.5 and PM10 were the major air pollutants in Changchun, followed by SO2, NO2 and O3. The results also demonstrated that the daily concentrations of air pollutants had obvious seasonal differences. PM10 had higher daily mean concentrations in spring (May, dust storms), autumn (October, straw burning) and winter (November to April, coal burning). The mean daily number of outpatient AR visits in the warm season was higher than in the cold season. The prevalence of allergic rhinitis was significantly associated with PM2.5, PM10, SO2 and NO2, and the increased mobility was 10.2% (95% CI, 5.5%–15.1%), 4.9% (95% CI, 0.8%–9.2%), 8.5% (95% CI, −1.8%–19.8%) and 11.1% (95% CI, 5.8%–16.5%) for exposure to each 1-Standard Deviation (1-SD) increase of pollutant, respectively. Weakly or no significant associations were observed for CO and O3. As for lag effects, the highest Relative Risks (RRs) of AR from SO2, NO2, PM10 and PM2.5 were on the same day, and the highest RR from CO was on day 4 (L4). The results also indicated that the concentration of air pollutants might contribute to the development of AR. To summarize, this study provides further evidence of the significant association between ambient particulate pollutants (PM2.5 and PM10, which are usually present in high concentrations) and the prevalence of respiratory effects (allergic rhinitis) in the city of Changchun, located in Northeastern China. Environmental control and public health strategies should be enforced to

  6. Curative Effect of Unite Yupingfeng in Allergic Rhinitis Patients%联合玉屏风颗粒治疗变应性鼻炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨立新; 赵伍西; 周宁

    2013-01-01

    目的:研究联合玉屏风颗粒治疗变应性鼻炎(Allergic rhinitis ,AR)的疗效及对AR患者外周血白介素-4(Inter-leukin ,IL-4)和γ-干扰素(Interferon ,IFN-γ)的影响。方法:选择我院耳鼻喉科门诊2010年4月-2013年4月AR患者58例,随机分为治疗组与研究组,研究组在治疗组常规使用抗组胺药、抗白三烯药、鼻用或口服糖皮质激素治疗基础上加用玉屏风颗粒。同时选择健康体检者29例为对照组进行对照研究。治疗前及治疗后1个月、3个月、6个月测定外周血IL-4和IFN-γ的浓度,并观察临床症状及体征。结果:治疗组与研究组在治疗前及治疗期间体征评分比较无明显差异(P>0.05),IL-4和IFN-γ水平比较无明显差异(P>0.05)、治疗期间症状评分及疗效两组比较有差异(P<0.05)。停药后3个月两组在症状及体征评分、疗效、IL-4和IFN-γ的水平均有差异(P<0.05)。结论:联合玉屏风颗粒治疗AR可提高疗效,对AR患者的免疫状态有恢复作用且作用长久。%Objective :To investigate the curative effect of unite Yupingfeng in AR patients and effect on peripheral blood IL-4 and IFN-γin AR patients .Methods :58 AR patients were chosen in outpatients service of Otorhinolaryngolo-gy from April 2010 to April 2013 .58 AR patients were divided into treatment group and research group in random . Treatment group were treated with drug of antihistamine ,antileukotriene ,intranasal or oral corticosteroids ,Research group were treated with Yupingfeng particle in addition .29 Healthy controls were chosen .Peripheral blood concentra-tion of IL-4 and IFN-γwere measured before treatment and one month ,three months ,six months after treatment .Clini-cal symptoms and physical signs were observed .Results:Grade of physical signs weren’t different before treatment pe-riod and in treatment period between treatment group and research group (P>0

  7. Budesonide inhalation by nose in treating 40 patients with combined allergic rhinitis and asthma syndrome%经鼻吸入布地奈德治疗过敏性鼻炎-哮喘综合征40例

    Institute of Scientific and Technical Information of China (English)

    左扬松

    2012-01-01

    AIM To explore the effect and safety of budesonide inhalation by nose on combined allergic rhinitis and asthma syndrome (CARAS) . METHODS Eighty-two patients with CARAS were randomly divided into two groups. All patients were treated by atomization pots. The patients in the nose group (n = 40) received budesonide aerosol by nose-suction nozzle, while the others in the mouth group (n = 42) received budesonide aerosol by mouth-suction nozzle. The doses of the two groups were the same and the courses were both 8 weeks. The symptoms scorings, lung function (FEV1, PEF), levels of serum total IgE and eosinophil absolute values were observed before and after the treatment. RESULTS The symptoms scorings of nasal and thorax, the levels of IgE, and the eosinophil absolute values in both groups decreased obviously after the treatment (P 0.05) . The levels of FEV1 and PEF increased significantly in both groups, and those in the nose group were higher ( P < 0.01) . There was no severe adverse reaction in the two groups. CONCLUSION Budesonide inhalation by nose in treating CARAS can obviously improve symptoms and lung functions, reduce serum total IgE level, with few adverse reaction. Budesonide inhalation by nose is superior to inhalation by mouth.%目的 探讨经鼻吸入布地奈德治疗过敏性鼻炎-哮喘综合征(CARAS)的疗效及安全性.方法 82例CARAS急性发作期患者,随机分为2组,均采用口-鼻两用雾化罐.经鼻组(n=40)和经口组(n=42)分别经鼻和经口吸入布地奈德气雾剂,均每次1吸200 μg,早晚各1次,连续治疗8 wk.观察治疗前后症状评分、第一秒用力呼气容积(FEV1)、呼气峰流量(PEF)、血清总IgE、嗜酸粒细胞(EOS)绝对值的变化.结果 治疗后2组鼻部及胸部症状评分、血清总IgE水平、EOS绝对值均下降(P<0.01),经鼻组症状评分、总IgE水平低于经口组(P< 0.05或P<0.01),2组EOS绝对值无显著差异(P>0.05).2组FEV1、PEF水平均升高(P<0.01),经鼻组FEV1

  8. Analysis of food allergy in atopic dermatitis patients - association with concomitant allergic diseases

    Directory of Open Access Journals (Sweden)

    Jarmila Celakovská

    2014-01-01

    Full Text Available Background: A few reports demonstrate the comorbidity of food allergy and allergic march in adult patients. Aims and Objectives: To evaluate, if there is some relation in atopic dermatitis patients at the age 14 years and older who suffer from food allergy to common food allergens to other allergic diseases and parameters as bronchial asthma, allergic rhinitis, duration of atopic dermatitis, family history and onset of atopic dermatitis. Materials and Methods: Complete dermatological and allergological examination was performed; these parameters were examined: food allergy (to wheat flour, cow milk, egg, peanuts and soy, the occurrence of bronchial asthma, allergic rhinitis, duration of atopic dermatitis, family history and onset of atopic dermatitis. The statistical evaluation of the relations among individual parameters monitored was performed. Results: Food allergy was altogether confirmed in 65 patients (29% and these patients suffer significantly more often from bronchial asthma and allergic rhinitis. Persistent atopic dermatitis lesions and positive data in family history about atopy are recorded significantly more often in patients with confirmed food allergy to examined foods as well. On the other hand, the onset of atopic dermatitis under 5 year of age is not recorded significantly more often in patients suffering from allergy to examined foods. Conclusion: Atopic dermatitis patients suffering from food allergy suffer significantly more often from allergic rhinitis, bronchial asthma, persistent eczematous lesions and have positive data about atopy in their family history.

  9. New product development with the innovative biomolecular sublingual immunotherapy formulations for the management of allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Frati F

    2014-09-01

    Full Text Available Franco Frati,1 Lorenzo Cecchi,2,3 Enrico Scala,4 Erminia Ridolo,5 Ilaria Dell'Albani,1 Eleni Makrì,6 Giovanni Pajno,7 Cristoforo Incorvaia6 1Medical and Scientific Department, Stallergenes, Milan, Italy; 2Interdepartmental Centre of Bioclimatology, University of Florence, Florence, Italy; 3Allergy and Clinical Immunology Section, Azienda Sanitaria di Prato, Prato, Italy; 4Experimental Allergy Unit, IDI-IRCCS, Rome, Italy; 5Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy; 6Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 7Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy Abstract: The molecular allergy technique, currently defined as component-resolved diagnosis, significantly improved the diagnosis of allergy, allowing for differentiation between molecules actually responsible for clinical symptoms (genuine sensitizers and those simply cross-reacting or shared by several sources (panallergens, thus influencing the appropriate management of a patient's allergy. This also concerns allergen immunotherapy (AIT, which may be prescribed more precisely based on the component-resolved diagnosis results. However, the advance in diagnosis needs to be mirrored in AIT. According to consensus documents and to expectations of specialists, therapy should be based on standardized extracts containing measured amounts of the clinically relevant molecules, ie, the major allergens. The new generation of extracts for sublingual immunotherapy fulfills these requirements and are thus defined as biomolecular (BM. BM refers to natural extracts with a defined content of major allergens in micrograms. All Staloral BM products are indicated for the treatment of allergic rhinitis with or without asthma. The effectiveness of AIT is related to its ability to modify the immunological response of allergic subjects. The 5-grass and house dust mite extracts were evaluated addressing the T helper 1, T

  10. [Aeroallergens, skin tests and allergic diseases in 1091 patients].

    Science.gov (United States)

    Enríquez Palomec, O; Hernández Chávez, L; Sarrazola Sanjuan, D M; Segura Méndez, N H; Hernández Colín, D D; Martínez-Cairo, S

    1997-01-01

    To know the frequency of positively of several skin tests, data cards from patients, of the Allergy and Clinic Immunology Service of the Hospital de Especialidades del Centro Medico Nacional Siglo XXI (Mexico City), between January, 1989 and March, 1995, were reviewed. Aqueous extracts manufactures by our laboratory were applied, in a dilution of 1:1000 weight-volume. 1091 from 5,651 skin tests patients were positive. Asthma and rhinitis were diagnosed in 492, allergic rhinitis in 289, allergic asthma in 111, and other diagnosis in 199 cases. The most frequent inhalable aeroallergens were house dust and perennial Dermatophagoides p and f1 with predominance in the rainy season, followed by pollens from Fraxinus a. Quercus a and Capriola, with predominance in the rainy season. The most frequent fungi were Candida and Fusarium, with predominance in the dry season.

  11. A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis

    NARCIS (Netherlands)

    Jin, Peng; Andiappan, Anand Kumar; Quek, Jia Min; Lee, Bernett; Au, Bijin; Sio, Yang Yie; Irwanto, Astrid; Schurmann, Claudia; Grabe, Hans Joergen; Suri, Bani Kaur; Matta, Sri Anusha; Westra, Harm-Jan; Franke, Lude; Esko, Tonu; Sun, Liangdan; Zhang, Xuejun; Liu, Hong; Zhang, Furen; Larbi, Anis; Xu, Xin; Poidinger, Michael; Liu, Jianjun; Chew, Fook Tim; Rotzschke, Olaf; Shi, Li; Wang, De Yun

    2015-01-01

    Background: Brain-derived neurotrophic factor (BDNF) is a secretory protein that has been implicated in the pathogenesis of allergic rhinitis (AR), atopic asthma, and eczema, but it is currently unknown whether BDNF polymorphisms influence susceptibility to moderate-to-severe AR. Objective: We sough

  12. Jackfruit anaphylaxis in a latex allergic patient.

    Science.gov (United States)

    Wongrakpanich, Supakanya; Klaewsongkram, Jettanong; Chantaphakul, Hiroshi; Ruxrungtham, Kiat

    2015-03-01

    Several fruits have been reported to crossreact with latex antigen in latex allergy patients but little is known regarding tropical fruits in particular. Here we report the case of a 34-year old nurse who developed anaphylaxis following the ingestion of dried jackfruit (Artocarpus heterophyllus). The patient had a history of chronic eczema on both hands resulting from a regular wear of latex gloves. She and her family also had a history of atopy (allergic rhinitis and/or atopic dermatitis). The results of skin prick tests were positive for jackfruit, latex glove, kiwi and papaya, but the test was negative for banana. While we are reporting the first case of jackfruit anaphylaxis, further research needs to be conducted to identify the mechanisms underlying it. In particular, in-vitro studies need to be designed to understand if the anaphylaxis we describe is due to a cross reactivity between latex and jackfruit or a coincidence of allergy to these 2 antigens.

  13. [Rhinitis in adults].

    Science.gov (United States)

    Kalogjera, Livije

    2011-01-01

    Rhinitis is a very common disorder caused by inflammation or irritation of nasal mucosa. Dominant symptoms are nasal obstruction; however, in some patients, runny nose, excessive sneezing or nasal itch may be the most bothersome symptoms. The most common causes of nasal inflammation are viral infections and allergic response to airborne allergens. Response to irritants may cause similar symptoms, although signs of inflammation may not always be present. Viral rhinitis is lasting up to 10 days and it is part of the common cold syndrome. In short-lived rhinitis, lasting for 7 to 10 days, sometimes it is not easy to differentiate between the potential causes of the disorder, if general symptoms of infection like fever and malaise are not present. In long-living rhinitis, it is important to differentiate between infectious, allergic, non-allergic non-infectious rhinitis, and chronic rhinosinusitis. Itch and ocular symptoms are more common in allergic rhinitis, while other symptoms like nasal obstruction, rhinorrhea and sneezing may affect patients with allergic and non-allergic rhinitis. Patients with allergic rhinitis often have symptoms after exposure to irritants, temperature and humidity changes, like patients with non-allergic rhinitis, and such exposure may sometimes cause more severe symptoms than exposure to allergens. Sensitivity to a non-specific trigger is usually called non-specific nasal hyperreactivity. Allergic rhinitis occurs due to immunoglobulin E (IgE) interaction with allergen in contact with nasal mucosa in a sensitized patient. Sensitization to certain airborne allergen, like pollens, dust, molds, animal dander, etc. usually occurs in families with allergy background, which is helpful in making diagnosis in patients who have rhinitis in a certain period of the year, or aggravation of nasal symptoms occurs in the environment typical of certain allergen. The diagnosis is clinically confirmed by proving sensitivity to certain allergen on skin prick

  14. Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.

    Directory of Open Access Journals (Sweden)

    Ruo-Xi Chen

    Full Text Available BACKGROUND: The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. OBJECTIVE: To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER due to house dust mites in a Chinese population. METHODS: In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays. RESULTS: In the single-locus analysis, three polymorphisms, rs3918392 (F1, rs528557 (S2 and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2-4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50-2.62 than those with 0-1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49-0.90. CONCLUSIONS: Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population.

  15. Resolution of Allergic Rhinitis and Reactive Bronchospasm With Supplements and Food-specific Immunoglobulin G Elimination: A Case Report.

    Science.gov (United States)

    Kwiatkowski, Laura; Mitchell, Jessica; Langland, Jeffrey

    2016-10-01

    Context • Allergies are a common affliction, whether they are respiratory, food related, or dermatological. People often resort to continuous use of over-the-counter medications, such as antihistamines, to manage their symptoms. Controversy still remains over testing serum immunoglobulin (Ig) G to diagnose food allergies. Objective • This study intended to examine the benefits of treatment of a pediatric patient with natural supplements and an elimination diet for IgG food allergies. Design • The research team reported a case study. Setting • The study was conducted at Southwest Naturopathic Medical Center (Tempe, AZ, USA). Participant • The participant was a 10-y-old Caucasian female who had diagnoses of allergic rhinitis and reactive bronchospasm, the second of which was exacerbated by allergens such as wheat, perfumes, and seasonal flora. Intervention • Following testing for IgE- and IgG-reactive foods, the patient was treated with natural supplements to reduce her allergic responses and was instructed to make dietary changes to eliminate the IgG-reactive foods. Outcome Measures • The patient's symptom severity was tracked starting 1 mo after her initial visit to Southwest Naturopathic Medical Center. The severity was based on the patient's subjective reports about her congestion to her mother and on her mother's observations of the effect of symptoms on her attention and school performance. The bronchospasm severity was based on the frequency of a sensation of wheezing and chest tightness, the frequency of inhaler use, and the occurrence of any exacerbation of symptoms with acute respiratory illness Results • After 1 mo, in which the patient used the natural supplements, she experienced a 90% improvement in coughing; a 70% improvement in nasal congestion; less chest tightness; and no need for use of loratadine, diphenhydramine, or albuterol. At the 8-mo follow-up visit, her nasal congestion was reported to be entirely gone. Conclusions • The

  16. Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs.

    Science.gov (United States)

    Nagira, Yoji; Goto, Kumiko; Tanaka, Hiroyuki; Aoki, Miwa; Furue, Shingo; Inagaki, Naoki; Tomita, Yasuhiko; Shichijo, Michitaka

    2016-05-01

    Prostaglandin D2(PGD2) is involved in the pathogenesis of allergic rhinitis. However, the sensory nervous system-mediated contributions of PGD2to the symptoms of allergic rhinitis remain unclear. We investigated the involvement of PGD2in these symptoms and in neuronal excitation by in vivo and ex vivo experiments. In an ovalbumin-induced model of allergic rhinitis in guinea pigs, the number of sneezing, nasal rubbing, and nasal secretion events were assessed after the nasal cavity instillation of PGD2, histamine, or a combination of PGD2and histamine. In situ hybridization for PGD2receptor 1 (DP1) mRNA transcripts and immunohistochemical analysis of histamine H1receptor protein expression in guinea pig trigeminal ganglion (TRG) were performed. The effects of DP1receptor activation on the excitability of TRG neurons to electrical and histamine stimuli were assessed using whole-cell patch-clamp recordings. Histamine induced more sneezing, nasal rubbing, and nasal secretion events than PGD2 PGD2augmented histamine-induced responses, whereas pretreatment with a DP1receptor-selective antagonist completely suppressed PGD2-induced augmentation. DP1receptor mRNA transcripts and H1receptor protein expression could be detected in TRG neurons. Moreover, a DP1receptor agonist caused significant increases in the number of histamine-induced action potentials and depolarization, and reduced the current threshold in small-diameter neurons. Our findings show that PGD2-DP1receptor signaling augments the symptoms of allergic rhinitis via the sensory nervous system by modulating nasal neuronal activation to various stimuli, such as histamine. These findings suggest that DP1receptor antagonist has therapeutic potential for the treatment of allergic rhinitis.

  17. Hypertonic saline is more effective than normal saline in seasonal allergic rhinitis in children.

    Science.gov (United States)

    Marchisio, P; Varricchio, A; Baggi, E; Bianchini, S; Capasso, M E; Torretta, S; Capaccio, P; Gasparini, C; Patria, F; Esposito, S; Principi, N

    2012-01-01

    Allergic rhinitis (AR) is a very common childhood disease that is associated with a significant reduction in the patients' quality of life. Its treatment combines educating the patients and their parents, immunotherapy and drug administration. However, even the best approach does not relieve the symptoms of a number of patients. Alternative therapies are particularly needed for children because the fear of adverse events frequently reduces parental compliance to the prescribed drugs, and immunotherapy is less easy to administer than in adults. In this prospective investigator-blinded study we evaluated whether children, with a documented history of seasonal grass pollen-related AR, benefit from nasal irrigation by assessing the effects on nasal signs and symptoms, on middle ear effusion and on adenoidal hypertrophy. We randomized children aged 5 to 9 years (median age 82 months) to normal saline or hypertonic saline (a 2.7% sodium chloride solution), administered twice-daily using a disposable 20 ml syringe, or no treatment. Nasal symptoms (rhinorrhea, itching, sneezing, nasal obstruction), swelling of turbinates, adenoid hypertrophy or middle ear effusion were assessed at baseline and after 4 weeks of treatment. Two hundred and twenty children (normal saline: 80; hypertonic saline: 80; no treatment: 60) completed the study. After four weeks, all the considered items were significantly reduced in the group receiving hypertonic saline (P < 0.0001), whereas in the group receiving normal saline only rhinorrhea (P = 0.0002) and sneezing (P = 0.002) were significantly reduced. There was no significant change in any of the items in the control group. The duration of oral antihistamines was significantly lower in the children receiving hypertonic saline than in those treated with normal saline or in controls. No adverse events were reported and parental satisfaction and compliance with the procedure were globally very good, regardless of the solution used. Using our

  18. Antioxidant properties of Aller-7, a novel polyherbal formulation for allergic rhinitis.

    Science.gov (United States)

    D'Souza, P; Amit, A; Saxena, V S; Bagchi, D; Bagchi, M; Stohs, S J

    2004-01-01

    Allergic rhinitis, a frequently occurring immunological disorder affecting men, women and children worldwide, is a state of hypersensitivity that occurs when the body overreacts to a substance such as pollen, mold, mites or dust. Allergic rhinitis exerts inflammatory response and irritation of the nasal mucosal membranes leading to sneezing; stuffy/runny nose; nasal congestion; and itchy, watery and swollen eyes. A novel, safe polyherbal formulation (Aller-7/NR-A2) has been developed for the treatment of allergic rhinitis using a unique combination of extracts from seven medicinal plants including Phyllanthus emblica, Terminalia chebula, Terminalia bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale and Piper longum. In this study, the antioxidant efficacy of Aller-7 was investigated by various assays including hydroxyl radical scavenging assay, superoxide anion scavenging assay, 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2-azinobis-ethyl-benzothiozoline-sulphonic acid diammonium salt (ABTS) radical scavenging assays. The protective effect of Aller-7 on free radical-induced lysis of red blood cells and inhibition of nitric oxide release by Aller-7 in lipopolysaccharide-stimulated murine macrophages were determined. Aller-7 exhibited concentration-dependent scavenging activities toward biochemically generated hydroxyl radicals (IC50 741.73 microg/ml); superoxide anion (IC50 24.65 microg/ml by phenazine methosulfate-nicotinamide adenine dinucleotide [PMS-NADH] assay and IC50 4.27 microg/ml by riboflavin/nitroblue tetrazolium [NBT] light assay), nitric oxide (IC50 16.34 microg/ml); 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical (IC50 5.62 microg/ml); and 2,2-azinobis-ethyl-benzothiozoline-sulphonic acid diammonium salt (ABTS) radical (IC50 7.35 microg/ml). Aller-7 inhibited free radical-induced hemolysis in the concentration range of 20-80 microg/ml. Aller-7 also significantly inhibited nitric oxide release from lipopolysaccharide-stimulated murine

  19. Vitamin D Deficiency and Allergic Rhinitis in Children: A Narrative Review

    Directory of Open Access Journals (Sweden)

    Javad Ghaffari

    2015-07-01

    Full Text Available Context: Allergic diseases such as allergic rhinitis (AR and immune-mediated inflammatory diseases are the most common chronic diseases among children. Although the cause of AR has yet to be clearly identified, genetic and environmental factors are known to play an important role in the development of the disease. Evidence Acquisition: In a more recent classification, AR is categorized as intermittent and permanent. Vitamin D has a known and important role in the absorption of calcium and preservation of bone density. The prevalence of vitamin D deficiency in children is reported to be between 30% and 50% in the world. Vitamin D confers the growth and development of the immune system including the development of regulatory T cells. Results: Two-thirds of the reviewed articles show a correlation between serum levels of vitamin D and allergic diseases, while the reaming ones demonstrate no correlation between vitamin D and AR and some even report a rise in the incidence of AR following the use of vitamin D supplement. Conclusions: It seems that further clinical trials and meta-analytic studies are necessary to confirm this correlation. The present study aimed at reviewing vitamin D deficiency in children with AR.

  20. Expression of Toll-like receptors in nasal epithelium in allergic rhinitis.

    Science.gov (United States)

    Renkonen, Jutta; Toppila-Salmi, Sanna; Joenväärä, Sakari; Mattila, Pirkko; Parviainen, Ville; Hagström, Jaana; Haglund, Caj; Lehtonen, Mikko; Renkonen, Risto

    2015-08-01

    Toll-like receptors (TLRs) are important in barrier homeostasis, but their role in airborne allergies is not fully understood. The aim was to evaluate baseline and allergen-induced expression of TLR proteins in nasal epithelium during allergic rhinitis. Nineteen otherwise healthy non-smoking volunteers both allergic to birch pollen and non-allergic controls were enrolled. We took nasal biopsies before and after off-seasonal intranasal birch pollen or diluent challenge. The expression of epithelial TLR1-7, TLR9-10, and MyD88 proteins was immunohistochemically evaluated from the nasal biopsies. The TLR1-3 and TLR5-10 mRNAs were observed by RNA-microarray. Baseline epithelial expression of TLR proteins was wide and identical in controls and atopics. After off-seasonal intranasal birch pollen challenge, a negative change in the expression score of TLR1 and TLR6 proteins was detected in the atopic group. TLR mRNA expression was not affected by birch pollen challenge. Nasal epithelium seems to express all known TLRs. The mechanisms by which TLR1, and TLR6 proteins could affect pollen allergen transport need further studies.

  1. Allergic rhinitis

    Science.gov (United States)

    ... invader References Baroody FM, Naclerio RM. Allergy and immunology of the upper airway. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap ...

  2. Allergic Rhinitis

    Science.gov (United States)

    ... dust mites, are in dust. Dust mites are tiny living creatures found in bedding, mattresses, carpeting and upholstered furniture. They live on dead skin cells and other things found in house dust. Diagnosis & TestsHow do I know what I' ...

  3. 变应性鼻炎患者伴发食物变应原致敏的特异性抗体检测分析%Detection and analysis of specific antibodies of food allergens in patients with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    王俊阁; 陈钢; 俞琳琳; 李婉英; 盖建青; 闫新宇; 吴慧莉

    2016-01-01

    [ABSTRACT]OBJECTIVETo investigate the relationship between food allergen specific IgE, IgG and allergic rhinitis, and to explore the significance of food allergen in the diagnosis and prevention of allergic rhinitis.METHODSTen kinds of food specific IgE were detected by Western blot and 14 kinds of food specific IgG were detected by ELISA in 2860 allergic rhinitis patients. The positive results of specific IgE and specific IgG were retrospectively analyzed.RESULTSThere was no difference in positive rate of allergen in patients with different gender. Total positive rate of food specific IgE was 68.5%. The specific IgE positive rate of crab was 31.5%, shrimp 27.6%, milk 21.3%, fish assemblages 19.2%, freshwater fish assemblages 18.3% and soybean 17.2%. With the growth of age, the specific IgE positive rate of peanut increased, but eggs decreased. The total positive rate of food allergen specific IgG was 81.5%. The specific IgG positive rate of egg was 59.4%, milk 38.2%, codfish 32.6%, soybean 22.8%, rice 19% and shrimp 12.7%. With the growth of age, the specific IgG positive rate of crab increased. Specific IgE and IgG of soybean, milk, crab, shrimp and fish were correlated well.CONCLUSIONThe detection of specific food allergen antibodies is helpful for the diagnosis of allergic rhinitis.%目的:研究食物变应原特异性IgE(specific IgE,sIgE)、sIgG与变应性鼻炎的关系,探讨食物变应原在变应性鼻炎诊断和预防中的意义。方法对2860例变应性鼻炎患者采用免疫印迹法检测10种食物sIgE和ELISA法检测14种食物sIgG阳性结果进行回顾性分析。结果变应原阳性率在不同性别患者间无差别。食物sIgE总阳性率为68.5%,依次为螃蟹(31.5%)、虾(27.6%)、牛奶(21.3%)、海鱼组合(19.2%)、淡水鱼组合(18.3%)、大豆(17.2%),其中花生随年龄增长,阳性率增加,鸡蛋则降低。食物变应原sIgG总阳性率81.5%,以鸡蛋(59.4%

  4. The clinical study on seasonal rhythm of melatonin and nitric oxide of patients with allergic rhinitis%变应性鼻炎患者血清褪黑素、一氧化氮水平的季节测定及临床意义

    Institute of Scientific and Technical Information of China (English)

    张波; 郭燕冰; 许继宗; 王普艳; 李洁; 司英奎

    2015-01-01

    目的:探讨变应性鼻炎患者血清褪黑素及一氧化氮( nitric oxide,NO)水平的季节变化及临床意义。方法选择符合变应性鼻炎标准的成年患者41例,其中男21例、女20例。采取自身对照的方法,分别在春分、夏至、秋分、冬至4个节气的前后各1个月进行血清褪黑素、NO水平的检测。结果血清褪黑素水平秋冬季节有较高表达,秋春、冬春、秋夏、冬夏对比差异有显著性(P<0.01);血清NO水平在冬季有较高表达,冬春对比差异有显著性(P<0.01),冬夏对比差异有显著性(P<0.01)。血清褪黑素、NO在春、夏、秋三季的水平变化有显著的相关性(春季r分别为0.518、0.518,P<0.01;夏季r分别为0.485、0.485,P<0.01;秋季r分别为0.437、0.437,P<0.01)。结论血清褪黑素、NO水平季节变化的表达,进一步验证了中医“天人相应”的理论,在变应性鼻炎发病过程中起到较重要的作用,对临床的预防及诊治有较大的参考价值。%Objective To assess whether the levels of serum melatonin and nitric oxide ( NO) correlate with reasons in allergic rhinitis patients. Method 41 allergic rhinitis patients were selected which included male 21 cases;female 20 cases. Self-control method was taken and the levels of MT and NO were measured which obtained all serum sam-ples in one month near to Vernal Equinox, Summer Solstice, Autumn Equinox and Winter Solstice. Result The lev-els of melatonin were much higher in winter and autumn than those in spring and summer; the levels of NO were much higher in winter than those in spring and summer. Whether in spring, summer and autumn the levels of me-latonin and NO have significant correlations (in spring the r was 0. 518,0. 518 respectively, P<0. 01; in summer the r was 0. 485,0. 485 respectively, P<0. 01; in autumn the r was 0. 437,0. 437 respectively, P<0. 01). Conclusion The seasonal rhythm expression of melatonin and NO verified the Chinese medicine theory of

  5. New therapeutic strategies in allergic rhinitis%变应性鼻炎治疗新策略

    Institute of Scientific and Technical Information of China (English)

    沙骥超; 孟粹达; 修倩; 朱冬冬

    2016-01-01

    Allergic rhinitis (AR) is a nasal inflammatory,IgE-mediated disease that occurs when some individuals inhales something he or she is allergic to,such as pollen or animal dander.It is also a refractory disease with high prevalence in the field of rhinology.The treatment of AR is really a difficult and challenging task because of the high prevalence,economic burden and the interference to the quality of life.At present,nasal corticosteroid and antihistamines were the mainly therapies,however,there is up to 40% patients not satisfactory to these therapies.So exploring new therapy or target is necessary.This article will review the results of previous studies focused on the new therapies of AR.%变应性鼻炎(allergic rhinitis,AR)是机体吸入变应原后主要由IgE介导的鼻黏膜非感染性炎性疾病,是鼻科领域高患病率的难治性疾病.随着患病率的逐年增高,AR引起了一系列社会问题,包括对患者生活质量的影响、对工作、学习的干扰以及经济负担的逐渐加重.目前,AR的治疗任务及难度都面临着巨大的挑战,临床常用鼻用糖皮质激素和抗组胺药物控制鼻部症状,然而有研究显示,对疗效不满意的患者约高达40%.因而AR的治疗仍迫切需要开拓思路,探索新的有效治疗方法.本文对治疗AR新方法的临床研究进行综述.

  6. Prevalence of food and airborne allergens in allergic patients in Kerman

    OpenAIRE

    2014-01-01

    Background: Detection of various environmental allergens is the major challenge in allergic diseases and the only treatment is avoiding these allergens. The aim of this study was to determine the prevalence of food and airborne allergens in allergic patients using Skin Prick Test (SPT). Methods: A cross-sectional study was done on clinically confirmed patients of atopic-dermatitis (n=54), allergenic-rhinitis (n=64) and chronic-urticaria (n=39) who referred to asthma and allergy clinic at ...

  7. Effects of Bifidobacterium Breve Feeding Strategy and Delivery Modes on Experimental Allergic Rhinitis Mice.

    Directory of Open Access Journals (Sweden)

    Jian-jun Ren

    Full Text Available Different delivery modes may affect the susceptibility to allergic diseases. It is still unknown whether early intervention with probiotics would counteract this effect.The effect of different delivery modes on immune status and nasal symptoms was investigated on established allergic rhinitis (AR mouse model. In addition, the immunoregulatory effects and mechanisms of different feeding manners with Bifidobacterium breve(B. breve were examined.Live lyophilized B. breve was orally administered to BALB/c mice born via vaginal delivery(VD or cesarean delivery (CD for 8 consecutive weeks, after which they were sensitized by ovalbumin(OVA to establish experimental AR. Nasal symptoms, serum immunoglobulins, cytokines, splenic percentages of CD4(+CD25(+Foxp3(+ regulatory T(Treg cells and nasal eosinophil infiltration were evaluated.Compared with VD mice, mice delivered via CD demonstrated more serious nasal symptoms, higher concentrations of OVA-specific immunoglobulin (Ig E, more nasal eosinophils and lower percentages of splenic CD4(+CD25(+Foxp3(+Treg cells after establishing experimental AR. These parameters were reversed by administering B. breves hortly after birth. However, the effect of B. breve did not differ between different delivery modes.CD aggravates the nasal symptoms of AR mice compared to VD. This is the first report that oral administration of B. breve shortly after birth can significantly alleviate the symptoms of AR mice born via both deliveries, probably via activation of the regulatory capacity of CD4(+CD25(+Foxp3(+Treg cells.

  8. The effect of topical sodium cromoglycate on intranasal histamine challenge in allergic rhinitis.

    Science.gov (United States)

    Birchall, M A; Henderson, J C; Studham, J M; Pride, N B; Fuller, R W

    1994-12-01

    Topical sodium cromoglycate is used to treat allergic diseases of the upper and lower airways. To investigate its mechanisms of action, intranasal histamine challenge was used in nine subjects with perennial allergic rhinitis. After a preliminary day where subjects' reactivity thresholds (D100) for histamine were determined, intranasal sodium cromoglycate was administered in a double-blind, placebo-controlled fashion. Graded (D100/3, D100, D100X3), sequential challenges were performed on days 1 and 21 of each course, and responses measured by changes in nasal airway resistance, sneezes, secretion volume and secretion content: total protein, lysozyme and mucin. After a single dose of sodium cromoglycate, there was no change in resistance, but secretion volumes fell significantly (3.12 ml/5 min c.i. 2.83-3.4; placebo 3.61, c.i. 3.32-3.90: P = 0.026). After a 3-week-course, there was a significant fall in resistance (4.29 cm H2O/l/s, c.i. 3.85-4.72; placebo 5.45, c.i. 5.01-5.88: P sodium cromoglycate has both short- and long-term effects on nasal reactivity to histamine challenge. Acutely, there is a reduction in nasal lavage fluid volume which may be the result of reduced irritant receptor activity. After a 3-week course, there is a reduction in nasal resistance responses, a possible anti-inflammatory effect.

  9. Analysis of allergens with allergic rhinitis in Rizhao%山东省日照地区变应性鼻炎患者过敏原分析

    Institute of Scientific and Technical Information of China (English)

    黄咏梅; 乔秀军; 尹华; 牟军伟

    2011-01-01

    Objective To find out common allergens in Rizhao by investigating the allergens in patients with allergic rhinitis.Method The allergens in 686 patients with allergic rhinitis in Rizhao were detected by skin prick test.Results 509 of 686(74.20%)cases presented positive reaction,in which,the positive rate was 70.99%in inhalation group and 30.61%in food group,the most common inhalation allergen was pteronyssinus,then was dermatophagoides farinae,cockroaches;The most common food allergen was the jellyfish,then was peaches,peanuts.Conclusion The inhaled allergens were the main risk factors for allergic rhinitis,in which,mites was the most common allergens.%目的 通过对山东省日照地区变应性鼻炎患者进行过敏原检测及分析,筛查该地区常见过敏原.方法 采用皮肤点刺法对686例变应性鼻炎患者进行过敏原检测.结果 686例患者中过敏原阳性509例(74.20%),其中吸入组阳性率70.99%,较高的为户尘螨、粉尘螨、蟑螂;食物组阳性率30.61%,较高的为海蜇、桃子、花生.结论 吸入性变应原为日照地区过敏性鼻炎主要的致病因素,螨类为最常见的变应原.

  10. Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children

    DEFF Research Database (Denmark)

    Schoos, A-M M; Chawes, B L; Jelding-Dannemand, E

    2016-01-01

    aeroallergen exposure and sensitization and rhinitis to such allergens later in childhood. METHODS: Allergic sensitization to cat, dog, and house dust mites was diagnosed longitudinally using skin prick tests and specific IgE measurements at ½, 1½, 4, 6, and 13 years in 399 children from the Copenhagen...... Prospective Study on Asthma in Childhood2000 birth cohort. Rhinitis was diagnosed at 7 and 13 years. Allergen exposure was defined as dog or cat in the home during the 3rd trimester of pregnancy or the first year of life and as allergen levels of dog, cat, and house dust mite in bed dust samples at 1 year....... Associations between exposure and outcomes were analyzed by logistic regression and stratified for eczema status and test method (skin prick test and specific IgE). RESULTS: We found no association between dog or cat exposure in perinatal life and sensitization or rhinitis during childhood. Similarly...

  11. Modulation of immune tolerance with a Chinese traditional prescription inhibits allergic rhinitis in mice

    Directory of Open Access Journals (Sweden)

    Min-Qiang Xie

    2011-01-01

    Full Text Available Background : Allergic diseases substantially affect human health and social economy. The pathogenesis is to be further understood. The effect of current therapeutic remedies on allergic diseases is not satisfactory. Aims : This study aimed to inhibit allergic rhinitis in a mouse model with a Chinese traditional medical prescription, Bu-Zhong-Yi-Qi-Tang. Material and Methods : A mouse AR model was developed with ovalbumin (OVA plus adjuvant alum. The AR clinical symptoms and immune pathology in the nasal mucosa were assessed with the AR mouse model. Some mice were treated with Bu-Zhong-Yi-Qi-Tang via gavage-fed. The immune tolerance status in the nasal mucosa was evaluated by counting the numbers of tolerogenic dendritic cells (DC and regulatory T cells (Treg. Results : After exposure to the specific antigen, OVA, the sensitized mice had AR-like symptoms including nasal itch and sneeze. The frequency of mast cells, levels of IgE/IL-4 in nasal mucosa was markedly higher in sensitized mice than naïve controls; while the levels of integration alphavbeta6 (avb6, the number of tolerogenic DCs and Tregs in nasal mucosa were significantly lower than naïve control mice. The AR-like symptoms and immune pathology and immune tolerance status in the AR nasal mucosa were substantially improved by administration with Bu-Zhong-Yi-Qi-Tang. Conclusions : The immune tolerance status is impaired in the AR nasal mucosa that can be improved by administering with Bu-Zhong-Yi-Qi-Tang.

  12. 变应性鼻炎患者焦虑状态分析%The impact of allergic rhinitis on state-trait anxiety

    Institute of Scientific and Technical Information of China (English)

    锡琳; 曹飞飞; 熊巍; 贺飞; 张罗

    2014-01-01

    Objective To investigate the relationship between the different types of allergic rhinitis and anxiety.Methods State-trait anxiety (State-Trait Anxiety Inventory,STAI) was adopted to 98 cases,moderate to severe persistent allergic rhinitis (PAR,male 43 cases,female 55 cases) and 165 cases of moderate to severe intermittent allergic rhinitis (IAR,male 89 cases,female 76 cases) and compared with the Chinese standard norm.SPSS 15.0 software was used to analyze the data.Results There was no significant difference in state anxiety (S-AI) and trait anxiety (T-AI) score (PPAR:0.411,0.724 ; PIAR:0.400,0.061) between male patients with allergic rhinitis (PAR and IAR) and the 1998 Chinese male norm.There was no significant difference (PPAR:0.503,P1AR:0.789) between female AR patients and normal in T-AI.The S-AI score was significantly higher in female AR patients than that in Chinese women norm scores (PPAR =0.007,PIAR =0.004).PAR and IAR showed no significant difference on T-AI and S-AI.(P value was 0.748 and 0.967).Conclusions Female patients with allergic rhinitis can cause anxiety and continued,but there is no obvious anxiety potential in T-AI.The male patients do not show significantly different from normal people in terms of state and trait anxiety.And then,different types of allergic rhinitis have no significant correlation with anxiety.%目的 探讨不同性别及不同类型变应性鼻炎患者与焦虑状态的关系.方法 采用状态-特质焦虑问卷(State-Trait Anxiety Inventory,STAI)对98例中-重度持续性变应性鼻炎(persistent allergic rhinitis,PAR)患者(其中男43例,女55例)和165例中-重度间歇性变应性鼻炎(intermittent allergic rhinitis,IAR)患者(其中男89例,女76例)进行焦虑状态分析,并与国人标准常模进行比较.采用SPSS 15.0软件进行统计学分析.结果 男性变应性鼻炎(allergic rhinitis,AR)患者(PAR和IAR)与1998年国人男性常模在状态焦虑和特质焦虑得分上差异无

  13. Allergic rhinitis, feeding and oral habits, toothbrushing and socioeconomic status. Effects on development of dental caries in primary dentition.

    Science.gov (United States)

    Vázquez-Nava, F; Vázquez, R E M; Saldivar, G A H; Beltrán, G F J; Almeida, A V M; Vázquez, R C F

    2008-01-01

    The aim was to determine the effect of feeding and oral habits, toothbrushing, socioeconomic status and allergic rhinitis on the development of dental caries in primary dentition. In a cross-sectional study, data were obtained by means of a structured questionnaire on 1,160 children, 4-5 years old (mean = 4.5 +/- 0.5) and born in 1999, 2000 or 2001. The children also had a physical examination by an allergist and dentists. Dental caries was diagnosed according to WHO criteria. Caries experience was measured as number of deft and defs. Logistic regression analysis assessed the association between dental caries and independent variables. The dental caries prevalence was 17.9%, 28.8% of the children had allergic rhinitis symptoms, digit sucking was reported by 9.8% and pacifier use by 13.6% of the children. The mean number of deft of the sample was 1.02 (SD = 2.37) and that of defs was 1.33 (SD = 3.54). Analysis showed that breast-feeding for >12 months (p < 0.01), toothbrushing frequency (p < 0.01), sugar consumption (p < 0.01) and pacifier use (p < 0.01) each had a significant association with dental caries occurrence in primary dentition. Children with pacifier use and allergic rhinitis had more than double the risk of dental caries development. Allergic rhinitis alone has no effect on dental caries. Healthcare professionals attempting to limit dental caries should consider the effect of prolonged breast-feeding, sugary product consumption between meals and nonnutritive habits on dental caries.

  14. The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: a narrative review and proposed model.

    Science.gov (United States)

    McDonald, John L; Cripps, Allan W; Smith, Peter K; Smith, Caroline A; Xue, Charlie C; Golianu, Brenda

    2013-01-01

    Classical literature indicates that acupuncture has been used for millennia to treat numerous inflammatory conditions, including allergic rhinitis. Recent research has examined some of the mechanisms underpinning acupuncture's anti-inflammatory effects which include mediation by sympathetic and parasympathetic pathways. The hypothalamus-pituitary-adrenal (HPA) axis has been reported to mediate the antioedema effects of acupuncture, but not antihyperalgesic actions during inflammation. Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of proinflammatory cytokines (such as TNF- α , IL-1 β , IL-6, and IL-10), proinflammatory neuropeptides (such as SP, CGRP, and VIP), and neurotrophins (such as NGF and BDNF) which can enhance and prolong inflammatory response. Acupuncture has been reported to suppress the expression of COX-1, COX-2, and iNOS during experimentally induced inflammation. Downregulation of the expression and sensitivity of the transient receptor potential vallinoid 1 (TRPV1) after acupuncture has been reported. In summary, acupuncture may exert anti-inflammatory effects through a complex neuro-endocrino-immunological network of actions. Many of these generic anti-inflammatory effects of acupuncture are of direct relevance to allergic rhinitis; however, more research is needed to elucidate specifically how immune mechanisms might be modulated by acupuncture in allergic rhinitis, and to this end a proposed model is offered to guide further research.

  15. The Anti-Inflammatory Effects of Acupuncture and Their Relevance to Allergic Rhinitis: A Narrative Review and Proposed Model

    Directory of Open Access Journals (Sweden)

    John L. McDonald

    2013-01-01

    Full Text Available Classical literature indicates that acupuncture has been used for millennia to treat numerous inflammatory conditions, including allergic rhinitis. Recent research has examined some of the mechanisms underpinning acupuncture's anti-inflammatory effects which include mediation by sympathetic and parasympathetic pathways. The hypothalamus-pituitary-adrenal (HPA axis has been reported to mediate the antioedema effects of acupuncture, but not antihyperalgesic actions during inflammation. Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of proinflammatory cytokines (such as TNF-α, IL-1β, IL-6, and IL-10, proinflammatory neuropeptides (such as SP, CGRP, and VIP, and neurotrophins (such as NGF and BDNF which can enhance and prolong inflammatory response. Acupuncture has been reported to suppress the expression of COX-1, COX-2, and iNOS during experimentally induced inflammation. Downregulation of the expression and sensitivity of the transient receptor potential vallinoid 1 (TRPV1 after acupuncture has been reported. In summary, acupuncture may exert anti-inflammatory effects through a complex neuro-endocrino-immunological network of actions. Many of these generic anti-inflammatory effects of acupuncture are of direct relevance to allergic rhinitis; however, more research is needed to elucidate specifically how immune mechanisms might be modulated by acupuncture in allergic rhinitis, and to this end a proposed model is offered to guide further research.

  16. Paediatric rhinitis

    DEFF Research Database (Denmark)

    Roberts, G; Xatzipsalti, M; Borrego, L M

    2013-01-01

    Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendat......Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence...... conditions such as adenoidal hypertrophy, septal deviation and nasal polyps. Examination by anterior rhinoscopy and allergy tests may help to substantiate a diagnosis of allergic rhinitis. Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). Oral and intranasal antihistamines and nasal...

  17. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Jurgita Saulyte

    2014-03-01

    Full Text Available Allergic rhinitis, allergic dermatitis, and food allergy are extremely common diseases, especially among children, and are frequently associated to each other and to asthma. Smoking is a potential risk factor for these conditions, but so far, results from individual studies have been conflicting. The objective of this study was to examine the evidence for an association between active smoking (AS or passive exposure to secondhand smoke and allergic conditions.We retrieved studies published in any language up to June 30th, 2013 by systematically searching Medline, Embase, the five regional bibliographic databases of the World Health Organization, and ISI-Proceedings databases, by manually examining the references of the original articles and reviews retrieved, and by establishing personal contact with clinical researchers. We included cohort, case-control, and cross-sectional studies reporting odds ratio (OR or relative risk (RR estimates and confidence intervals of smoking and allergic conditions, first among the general population and then among children. We retrieved 97 studies on allergic rhinitis, 91 on allergic dermatitis, and eight on food allergy published in 139 different articles. When all studies were analyzed together (showing random effects model results and pooled ORs expressed as RR, allergic rhinitis was not associated with active smoking (pooled RR, 1.02 [95% CI 0.92-1.15], but was associated with passive smoking (pooled RR 1.10 [95% CI 1.06-1.15]. Allergic dermatitis was associated with both active (pooled RR, 1.21 [95% CI 1.14-1.29] and passive smoking (pooled RR, 1.07 [95% CI 1.03-1.12]. In children and adolescent, allergic rhinitis was associated with active (pooled RR, 1.40 (95% CI 1.24-1.59 and passive smoking (pooled RR, 1.09 [95% CI 1.04-1.14]. Allergic dermatitis was associated with active (pooled RR, 1.36 [95% CI 1.17-1.46] and passive smoking (pooled RR, 1.06 [95% CI 1.01-1.11]. Food allergy was associated with SHS (1

  18. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy

    Energy Technology Data Exchange (ETDEWEB)

    Pesce, G., E-mail: giancarlo.pesce@univr.it [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy); Bugiani, M. [Unit of Respiratory Medicine and Allergology, CPA-ASL TO-2, Turin (Italy); Marcon, A.; Marchetti, P. [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy); Carosso, A. [Unit of Respiratory Medicine and Allergology, CPA-ASL TO-2, Turin (Italy); Accordini, S. [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy); Antonicelli, L. [Dept of Internal Medicine, Immuno-Allergic and Respiratory Diseases, Ospedali Riuniti di Ancona, Ancona (Italy); Cogliani, E. [Casaccia Research Centre, Italian National Agency for New Technologies, Energy, and Substainable Economic Development (ENEA), Rome (Italy); Pirina, P. [Institute of Respiratory Diseases, University of Sassari, Sassari (Italy); Pocetta, G. [Dept of Experimental Medicine, University of Perugia, Perugia (Italy); Spinelli, F. [Casaccia Research Centre, Italian National Agency for New Technologies, Energy, and Substainable Economic Development (ENEA), Rome (Italy); Villani, S. [Dept of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia (Italy); Marco, R. de [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy)

    2016-02-15

    Background: Several studies highlighted a great variability, both between and within countries, in the prevalence of asthma and chronic airways diseases. Aim: To evaluate if geo-climatic variations can explain the heterogeneity in the prevalence of asthma and respiratory diseases in Italy. Methods: Between 2006 and 2010, a postal screening questionnaire on respiratory health was administered to 18,357 randomly selected subjects, aged 20–44, living in 7 centers in northern, central, and southern Italy. A random-effects meta-analysis was fitted to evaluate the between-centers heterogeneity in the prevalence of asthma, asthma-like symptoms, allergic rhinitis, and chronic bronchitis (CB). A principal component analysis (PCA) was performed to synthetize the geo-climatic information (annual mean temperature, range of temperature, annual rainfalls, global solar radiations, altitude, distance from the sea) of all the 110 Italian province capital towns. The associations between these geo-climatic components obtained with PCA and the prevalence of respiratory diseases were analyzed through meta-regression models. Results: 10,464 (57%) subjects responded to the questionnaire. There was a significant between-centers heterogeneity in the prevalence of asthma (I{sup 2} = 59.5%, p = 0.022) and CB (I{sup 2} = 60.5%, p = 0.019), but not in that of asthma-like symptoms or allergic rhinitis. Two independent geo-climatic components explaining together about 80% of the overall geo-climatic variability were identified: the first principally summarized the climatic variables; the second the topographic ones. Variations in the prevalence of asthma across centers were significantly associated with differences in the climatic component (p = 0.017), but not with differences in the topographic one. Conclusions: Our findings suggest that climate play a role in determining the between-center heterogeneity in the prevalence of asthma in Italy, with higher prevalence in dry-hot Mediterranean

  19. Distribution of allergens in patients with allergic rhinitis in Hebei villagers and Tianjin citizens%河北地区村民与天津市民变应性鼻炎变应原谱比较

    Institute of Scientific and Technical Information of China (English)

    王泽海; 林文森; 王丽; 王小奇; 陈洁; 张振富; 于金珍

    2012-01-01

    目的 通过对变应性鼻炎( allergic rhinitis,AR)流行病学调查分析,获得河北地区生活村民(简称河北村民)与天津市生活市民(简称天津市民)以及其中AR确诊患者的变应原分布情况.方法 自2007年4月至2010年5月,通过随机整群和多级抽样,抽取河北村民与天津市民,进行直接面访调查和血清特异性IgE( specific IgE,sIgE)检测,应用SPSS 13.0软件对变应原分布数据进行统计学分析.结果 调查对象共计1524例.其中,河北村民1024例、天津市民500例,血清sIgE检测阳性率分别为27.2% (279/1024)和21.2% (106/500),差异有统计学意义(x2=7.13,P<0.01);AR患病率分别为9.2% (94/1024)和9.0% (45/500),差异无统计学意义(x2=0.01,P>0.05).狗上皮、猫上皮是河北农村地区AR的首要变应原,其次为粉尘螨、屋尘螨、桦木花粉(桦木)、牧草花粉(牧草);粉尘螨、屋尘螨是天津市区AR的首要变应原,其次为狗上皮、桦木、猫上皮、牧草.河北村民与天津市民AR变应原存在明显差异的变应原种类为:屋尘螨、粉尘螨和狗上皮(x2值分别为11.36、9.14、5.28,P值均<0.05).狗上皮变应原AR致病率河北村民较天津市民高,屋尘螨和粉尘螨变应原AR患病率天津市民较河北村民高.结论 变应原在AR患病中起重要作用,变应原存在地域和城乡差异.%Objective To investigate the epidemiology of allergic rhinitis(AR) and the distribution of allergens in villagers who lived in Hebei Province( Hebei villagers) and the citizens who lived in the city of Tianjin (Tianjin citizens).Methods From April 2007 to May 2010,face to face investigation and serum specific IgE (sIgE) examination were conducted among Hebei villagers and Tianjin citizens by randomly multi-stage and cluster sampling,and the results were analyzed. Results A total of 1524 cases were investigated,among them,1024 cases in Hebei and 500 cases in Tianjin,the prevalence of the sIgE test was

  20. Analysis of total and specific IgE in serum of carvota mitis pollen-induced allergic rhinitis patients%鱼尾葵花粉过敏的变应性鼻炎患者中血清总IgE及特异性IgE结果的分析

    Institute of Scientific and Technical Information of China (English)

    姚敏; 孟光

    2013-01-01

    Objective:Exploring the relationship between total and specific IgE in serum and allergen skin test of carvota mitis pollen-induced allergic rhinitis patients. Method; Four hundred and twenty-nine carvota mitis pollen-induced allergic rhinitis patients and 243 healthy control subjects were recruited. The experimental group carried out skin tests, and pollen-specific IgE were also examined by BSA-ELISA method. Total IgE in serum of all of the subjects were determined by ELISA. Result;The positive rate of the total IgE level of the patients were much higher than those of the controls(66. 2% vs. 15. 6% ,P<0. 01). No statistically significance was found between the positivity of skin test and serum specific IgE of the experimental group(χ2 =0. 7588,P>0. 05). The difference between serum-specific IgE and total IgE was statistically significant(χ2 = 50. 639, P<0. 01). There was no statistical significance of specific IgE and the total IgE in serum between long term residents in Haikou and Hainan Tourisms (P>0. 05). Conclusion; Allergen skin test and carvota mitis pollen-specific IgE are two effective methods for the diagnosis of carvota mitis pollen-induced allergic rhinitis . The detection of total IgE in serum of carvota mitis pollen-induced allergic rhinitis provides a reference value for diagnosis. The relationship between concentration of IgE in serum of the carvota mitis pollen-induced allergic rhinitis and allergen contact duration is waiting for further study.%目的:探讨鱼尾葵花粉过敏的变应性鼻炎(AR)患者中血清总IgE、特异性IgE和变应原皮肤试验之间的关系.方法:选择429例对鱼尾葵花粉过敏的AR患者为实验组,243例健康体检者为对照组.实验组进行皮肤试验和特异性IgE水平检测,鱼尾葵花粉特异性IgE采用BSA-ELISA法;所有个体均检测血清总IgE水平.结果:实验组血清总IgE的阳性率明显高于对照组的阳性率(分别为66.2%和15.6%,P<0.01)

  1. 变应性鼻炎治未病探讨%The discuss about preventive treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    严道南; 陈旭青; 吴继勇

    2016-01-01

    Allergic rhinitis disease is widespread and there is an upward trend in incidence year by year,so early treatment of allergic rhinitis is of great significance.With the support from the state administration of traditional Chinese medicine,our team has carried out the work of traditional Chinese medicine practice guidelines about preventive treatment of allergic rhinitis.The aim is to form advanced, standard, practical evidence-based otolaryngology of traditional Chinese medicine"preventive treatment"standard.At present, the group has finished ancient literature research, modern literature research, the Delphi expert questionnaire survey, expert discussion meeting and has formed first draft.Our team will strive to do a good job in the next step research work.Eventually formed practice guidelines not only guide the preventive treatment of allergic rhinitis and lay the basis of research work about the allergic rhinitis preventive treatment in the future, but also will enrich and perfect the system of traditional Chinese medicine preventive treatment,servicing in the cause of human health.%变应性鼻炎发病广泛且发病率呈逐年上升的趋势,故其治未病研究意义重大。本课题组在国家中医药管理局支持下开展了《治未病中医实践指南·鼻鼽》制订工作,旨在形成先进、规范、实用的循证中医耳鼻喉科“治未病”标准。目前课题组已完成古代文献研究、现代文献研究、德尔菲法专家问卷调查、召开专家论证会的研究工作,形成《中医治未病实践指南·鼻鼽(制订)》初稿,课题组必将努力做好下一步研究工作,最终形成的指南不仅为指导各地鼻鼽“治未病”工作,奠定今后鼻鼽中医治未病研究工作的基础,也将丰富和完善中医学治未病体系,为人类健康事业服务。

  2. Measuring outcomes in allergic rhinitis: psychometric characteristics of a Spanish version of the congestion quantifier seven-item test (CQ7

    Directory of Open Access Journals (Sweden)

    Mullol Joaquim

    2011-03-01

    Full Text Available Abstract Background No control tools for nasal congestion (NC are currently available in Spanish. This study aimed to adapt and validate the Congestion Quantifier Seven Item Test (CQ7 for Spain. Methods CQ7 was adapted from English following international guidelines. The instrument was validated in an observational, prospective study in allergic rhinitis patients with NC (N = 166 and a control group without NC (N = 35. Participants completed the CQ7, MOS sleep questionnaire, and a measure of psychological well-being (PGWBI. Clinical data included NC severity rating, acoustic rhinometry, and total symptom score (TSS. Internal consistency was assessed using Cronbach's alpha and test-retest reliability using the intraclass correlation coefficient (ICC. Construct validity was tested by examining correlations with other outcome measures and ability to discriminate between groups classified by NC severity. Sensitivity and specificity were assessed using Area under the Receiver Operating Curve (AUC and responsiveness over time using effect sizes (ES. Results Cronbach's alpha for the CQ7 was 0.92, and the ICC was 0.81, indicating good reliability. CQ7 correlated most strongly with the TSS (r = 0.60, p Conclusions The Spanish version of the CQ7 is appropriate for detecting, measuring, and monitoring NC in allergic rhinitis patients.

  3. Association pattern of interleukin-1 receptor-associated kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese population.

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    Yuan Zhang

    Full Text Available OBJECTIVE: Interleukin-1 receptor-associated kinase-4 (IRAK-4 encodes a kinase that is essential for NF-kB activation in Toll-like receptor and T-cell receptor signaling pathways, indicating a possible crosstalk between innate and acquired immunities. We attempted to determine whether the polymorphisms in the Interleukin-1 receptor-associated kinase-4 (IRAK-4 gene are associated with allergic rhinitis (AR in the Han Chinese population. METHODS: A population of 379 patients with AR and 333 healthy controls was studied. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE. A total of 11 single nucleotide polymorphisms (SNPs in IRAK-4 were selected and individually genotyped. RESULTS: Significant allelic differences between cases and controls were obtained for the SNP of rs3794262 in the IRAK-4 gene. In the stratified analysis for gender, two SNPs (rs4251431 and rs6582484 in males appeared as significant associations. Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262, rs4251481. None of the selected SNPs in IRAK-4 was associated with total IgE level. The haplotype analysis indicated GCCTGCGA was significantly associated with AR. The SNP-SNP interaction information analysis indicated that the selected sets of polymorphisms had no synergistic effect. CONCLUSIONS: Our findings did not support the potential contribution of the IRAK-4 gene to serum IgE levels. However, the results demonstrated a gender- and allergen-dependant association pattern between polymorphisms in IRAK-4 and AR in Chinese population.

  4. Sensitization Rates for Various Allergens in Children with Allergic Rhinitis in Qingdao, China.

    Science.gov (United States)

    Lin, Hang; Lin, Rongjun; Li, Na

    2015-09-07

    The aim of this study was to determine the prevalence of sensitization to common allergens in children with allergic rhinitis (AR) living in Qingdao, China. We conducted a retrospective analysis for AR cases, who underwent skin prick tests (SPT) in Qingdao. A total of 2841 children with AR qualified for the inclusion criteria (Age 3-5 years: 1500 children; Age 6-12 years: 1341 children). The most common inhaled allergens to which the AR children were sensitive were Dermatophagoides pteronyssinus (69.3%), Dermatophagoides farinae (66.2%) and mould 1 (Penicillium notatum 38.9%); while the corresponding ingested allergens were mussel (39.2%), shrimp (36.3%) and carp (36.5%). The prevalence of sensitization to inhaled allergens and food allergens was higher in children >6 years of age as compared to that in children 3-5 years of age (all p 6 years old were more sensitive to dust mite as compared to children 3-5 years old (p allergens causing AR in children in Qingdao, China. Older children with AR, particularly males, were found to be more sensitive to dust mite.

  5. Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis

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    Wenlong Liu

    2014-01-01

    Full Text Available Background. Interleukin-37 (IL-37, a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses, especially its isoform IL-37b. Objective. This study was undertaken to evaluate the expression and regulation of IL-37b in children with allergic rhinitis (AR. Methods. Forty children with AR and twenty-five normal controls were included. The relationship between IL-37b and Th1/2 cytokines production in serum and nasal lavage was examined by enzyme-linked immunosorbent assay (ELISA. Peripheral blood mononuclear cells (PBMCs were purified for in vitro regulation experiment of IL-37b. Intranasal mometasone furoate was given in AR children and IL-37b change after one-month treatment was detected using ELISA. Results. We observed significantly decreased IL-37b expression levels in both serum and nasal lavage compared to controls. IL-37b was negatively correlated with Th2 cytokines. Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and this modulation was through mitogen-activated protein kinase (MAPK and phosphatidylinositol 3-kinase (PI3K pathway. We also found that intranasal mometasone furoate therapy can promote nasal IL-37b expression. Conclusion. IL-37b may be involved in Th2 cytokine regulation in AR and its expression was related to the efficacy of intranasal steroid therapy.

  6. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms.

    Science.gov (United States)

    Wilson, Dale; Evans, Malkanthi; Guthrie, Najla; Sharma, Prachi; Baisley, Joshua; Schonlau, Frank; Burki, Carolina

    2010-08-01

    The potential of Pycnogenol for relieving allergic rhinitis (birch pollen) symptoms was explored in a double-blind, placebo-controlled trial. In 2008 19 subjects started treatment 3 weeks prior to the onset of birch pollen season in Ontario, Canada. While there was an improvement of eye and nasal symptoms with Pycnogenol, there was no significance versus placebo. It was postulated that Pycnogenol may require a lag-time between the start of therapy and the onset of action. Therefore 39 subjects were treated 5-8 weeks prior to the 2009 birch allergy season. The evaluation of subjects in 2009 showed much lower scores for eye (-35%) and nasal (-20.5%) symptoms with Pycnogenol compared with placebo. In succession of the allergy season birch specific IgE increased by 31.9% in the placebo group compared with only 19.4% in the Pycnogenol group. Detailed analysis suggested that symptom-relief was better the longer subjects were on Pycnogenol prior to the allergen exposure. The best results were found with subjects who took Pycnogenol 7-8 weeks ahead of the allergy season. With the limited number of 39 patients statistical predications were unattainable. In conclusion, Pycnogenol improved allergic rhinitis symptoms when supplementation was started at least 5 weeks before the onset of the allergy season.

  7. Occupational allergic rhinitis and contact urticaria caused by bishop's weed (Ammi majus).

    Science.gov (United States)

    Kiistala, R; Mäkinen-Kiljunen, S; Heikkinen, K; Rinne, J; Haahtela, T

    1999-06-01

    Bishop's weed (Ammi majus) has been known to induce toxic phytophotodermatitis. We now describe IgE-mediated rhinitis and contact urticaria caused by exposure to bishop's weed in a 31-year-old atopic female florist. A skin prick-prick test with bishop's weed flowers gave an 8-mm wheal, and the bishop's weed-specific IgE level in the patient's serum was 9.7 PRU/ml (RAST class 3). In an immunoblotting experiment with the patient's serum, nine IgE-binding protein bands with the molecular weights 19, 34, 39-41 (doublet), 52-61 (doublet), and >67 (triplet) kDa were detected in bishop's weed extract. The patient became symptomless after she had ceased to work as a florist.

  8. Sensitization to Airborne Ascospores, Basidiospores, and Fungal Fragments in Allergic Rhinitis and Asthmatic Subjects in San Juan, Puerto Rico

    Science.gov (United States)

    Rivera-Mariani, Félix E.; Nazario-Jiménez, Sylvette; López-Malpica, Fernando; Bolaños-Rosero, Benjamín

    2011-01-01

    Background Fungal spores are the predominant biological particulate in the atmosphere of Puerto Rico, yet their potential as allergens has not been studied in subjects with respiratory allergies. The purpose of this study was to determine the level of sensitization of subjects with respiratory allergies to these particles. Methods Serum samples were drawn from 33 subjects with asthma, allergic rhinitis, or nonallergic rhinitis and 2 controls with different skin prick test reactivity. An MK-3 sampler was used to collect air samples and the reactivity of the sera to fungal particles was detected with a halogen immunoassay. Results All subjects reacted to at least 1 fungal particle. Thirty-one subjects reacted to ascospores, 29 to basidiospores, 19 to hyphae/fungal fragments, and 12 to mitospores. The median percentage of haloes in allergic rhinitis subjects was 4.82% while asthma or nonallergic rhinitis subjects had values of 1.09 and 0.39%, respectively. Subjects with skin prick tests positive to 3, 2, 1, or no extract had 5.24, 1.09, 1.61, and, 0.57% of haloed particles, respectively. If skin prick tests were positive to basidiomycetes, pollen, animals, or deuteromycetes, the percentages of haloes were 4.72, 4.15, 3.63, and 3.31%, respectively. Of all haloed particles, 46% were unidentified, 25% ascospores, 20% basidiospores, 7% hyphae/fungal fragments, and 2% mitospores. IgE levels and the number of positive skin prick test extracts correlated with the percentage of haloes. Conclusion In tropical environments, sensitization to airborne basidiomycetes, ascomycetes, and fungal fragments seems to be more prevalent than sensitization to mitospores in subjects with active allergies, suggesting a possible role in exacerbations of respiratory allergies. PMID:21346362

  9. Effects of radiofrequency ablation of inferior turbinate on the nasal valve and the subjective nasal ventilation in patients with allergic rhinitis%下鼻甲等离子消融对变应性鼻炎患者鼻瓣区和主观鼻通气感觉的影响

    Institute of Scientific and Technical Information of China (English)

    李佩忠; 邱明玲

    2011-01-01

    Objective To observe the effects of radiofrequency ablation of inferior turbinate on the distribution of nasal airway resistance (NAR) and the subjective nasal ventilation in patients with allergic rhinitis. Method The distribution of NAR was studied in 50 patients with allergic rhinitis before and after radiofrequency ablation of inferior turbinate by using initiative anterior rhinomanometry. The patients' subjective nasal ventilation was also evaluated. Results Before the nasal mucosa of healthy subjects were decongested, NAR in the ostium intemum accounted for 15% of total NAR, while the piriform aperture and inferior turbinate front-end accounted for 37%, the cartilage section occupied 67%, and the osseous nasal cavity occupied 33%. After reducing congestion, NAR in the ostium internum increased to 32%, while the piriform aperture and inferior turbinate front-end decreased to 19%, and the osseous nasal cavity increased to 45%. Before radiofrequency ablation of inferior turbinate in patients with allergic rhinitis, NAR in the piriform aperture and inferior turbinate front-end accounted for 54% of total NAR, while the ostium internum accounted for 15%, the cartilage section occupied 78%, and the osseous nasal cavity occupied 22%. After ablation, NAR in the piriform aperture and inferior turbinate front-end decreased to 32%, while the piriform aperture and inferior turbinate front-end decreased to 21%, the ostium intemum increased to 37%, the cartilage section occupied 52%, and the osseous nasal cavity occupied 48%. Preoperative scores of the subjective nasal nasal ventilation were 7.5±1.5, and 3 months after operation the scores were 3.0±2.5 (P0.01). Conclusion Radiofrequency ablation of inferior turbinate can obviously reduce the NAR and improve the subjective nasal ventilation in patients with allergic rhinitis.%目的 观察下鼻甲等离子消融术对变应性鼻炎患者鼻气道阻力(NAR)在鼻腔中分布和主观鼻通气感觉的影响.方法 采

  10. Antileucotrienos no tratamento da asma e rinite alérgica Antileukotrienes in the treatment of asthma and allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Jose Dirceu Ribeiro

    2006-11-01

    Full Text Available OBJETIVO: Comparar os antagonistas de leucotrienos (ARLT aos outros grupos de medicamentos utilizados para tratar a asma e a rinite alérgica. FONTES DOS DADOS: MEDLINE, LILACS e Biblioteca Cochrane. Palavras chaves: leucotrienos, antileucotrienos, tratamento da asma, tratamento da rinite alérgica, asma e rinite alérgica. Procurou-se agrupar os principais trabalhos e revisões sobre o assunto. SÍNTESE DOS DADOS: Os ARLT são mais eficazes do que placebo e potencializam os efeitos dos corticosteróides inalados. A associação de corticosteróides inalados com agentes beta2 agonistas de longa duração (LABA é mais eficaz do que a associação de cortiscoteróides inalados + ARLT. Embora pareça racional o uso de ARLT na crise aguda de asma e rinite alérgica, mais estudos são necessários para comprovar esse benefício. Os ARLT promovem redução no tempo de hospitalização e no número de crises de sibilância em lactentes com bronquiolite viral aguda pelo vírus respiratório sincicial e na sibilância recorrente após bronquiolite viral aguda. Os ARLT são menos eficazes que os corticosteróides intranasais no manejo da rinite alérgica. Os ARLT são eficazes na asma induzida por exercício (AIE, embora não constituam a primeira linha de tratamento. CONCLUSÃO: Estudos controlados e randomizados mostram que os corticosteróides inalados são as drogas de escolha para o tratamento da asma persistente e rinite alérgica. :Não existem evidências suficientes para recomendar o uso de ARLT como medicamento de primeira linha (monoterapia em crianças com asma (nível I. Nas crianças que não podem usar corticosteróides inalados, os ARLT podem ser uma alternativa (nível II.OBJECTIVE: To compare leukotriene antagonists (LTA to other groups of drugs used in asthma and allergic rhinitis treatment. SOURCES: MEDLINE, LILACS and Cochrane Library. Keywords: leukotrienes, antileukotrienes, asthma treatment, allergic rhinitis treatment, asthma and

  11. Evaluation of serum specific IgE for the diagnosis of allergic rhinitis with multi-allergens

    Institute of Scientific and Technical Information of China (English)

    LIU Cheng-yao; ZHANG Yuan; HAN De-min; ZHANG Luo

    2010-01-01

    Background Objective evaluation of allergic rhinitis (AR) requires in vivo and in vitro tests. In vitro tests are important to assist or ensure the main allergens in multi-allergen-sensitive patients. The aim of this study was to evaluate the utility of serum specific IgE (slgE) in the diagnosis of AR patients with multi-allergens in the Chinese population.Methods Combining a positive skin prick test (SPT) and clinical history as the diagnostic reference criteria of AR, we estimated concentrations of slgE produced in response to the 7 most frequent allergens among 85 AR patients, using the UniCAP assay system.Results Among 85 individuals with positive SPT results and allergen-specific nasal symptoms, slgE concentration correlated well with SPT classes among all the tested allergens. Based on a clinical diagnosis and SPT results using a positive cut-off value of a class 1 score, the CAP test performed well and the sensitivity for different allergens ranged from 0.5 (giant ragweed) to 0.91 (Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f), while specificity ranged from 0.93 (Der f) to 1.0 (animal hair, Derp and mugwort). When the cut-off score was adjusted to class 2, the sensitivity showed an increase overall while the remaining assessed items, including specificity, positive predictive value, negative predictive value and efficiency, showed an unacceptable decline.Conclusions Well-established serum slgE tests correlated well with SPTs. Setting a class 1 cut-off for positivity of SPT results was better than a class 2 setting for assessing the AR diagnostic value.

  12. Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

    Science.gov (United States)

    Zhu, Zheng; Xie, Yanqing; Guan, Weijie; Gao, Yi; Xia, Shu; Shi, Xu

    2016-01-01

    Background The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear. Objective To evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR. Methods Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week. The correlations between nasal challenge tests induced nasal responses and QoL in RQoLQ were analyzed. Results A total of 25 eligible AR patients enrolled and finished both LTD4 and histamine nasal challenge and completed the questionnaire of RQoLQ. Histamine nasal challenge induced sneezing, increased nasal resistant were correlated with most of the dimensions (general, practical, nasal, eye problems, and quality of sleep, p < 0.05), while LTD4 nasal challenge induced sneeze, increased nasal resistant only correlated with nasal and ocular problems. On the contrary, the severity of the sneeze assessed by TSS4, was not correlated with QoL, while the severity of rhinorrhea, congestion, and nasal pruritus were correlated with nasal and practical problems, and nasal congestion was also correlated with ocular problems (r = 0.60, p = 0.01). Conclusion LTD4 and histamine nasal challenge induced nasal responses were correlated with different clinical symptoms severity and QoL, which can be used as a good diagnosis and evaluation methods for the management of AR.

  13. H1 antihistamines in allergic rhinitis: The molecular pathways of interleukin and toll - like receptor systems

    Directory of Open Access Journals (Sweden)

    Jonny Karunia Fajar

    2016-03-01

    Full Text Available The complex interaction between inflammatory mediators in allergic rhinitis (AR is determined by the role of genetic polymorphisms, including interleukin (IL and toll-like receptor (TLR genes. This study aimed to discuss the effects of H1-antihistamines on IL and TLR systems. Several ILs involved in AR pathogenesis are: IL-4 (rs2243250, rs1800925, rs1801275, rs2227284, rs2070874, IL-6 (rs1800795, rs1800797, IL-10 (rs1800871, rs1800872, IL-12R (rs438421, IL-13 (rs1800925, rs20541, IL-17 (rs3819024, IL-18 (rs360721, rs360718, rs360717, rs187238, IL-23R (rs7517847, and IL-27 (rs153109, rs17855750. In the IL system, histamines stimulate the IL production in Type 2 helper T (Th2 cells through protein kinase A (PKA, janus kinase-signal transducer and activator of transcription (JAK-STAT pathway, and the activation of H1-histamine receptor and histidine decarboxylase (HDC genes. On contrary, antihistamines down-regulate the H1-histamine receptor gene expression through the transcription suppression of HDC and IL genes and suppress histamine basal signaling through the inverse agonistic activity. TLRs involved in AR pathogenesis are TLR2 (rs4696480, rs3804099, rs5743708, TLR4 (rs4986790, TLR6 (rs2381289, TLR7 (rs179008, rs5935438, TRL8 (rs2407992, rs5741883, rs17256081, rs4830805, rs3788935, rs178998, and TLR10 (rs11466651. In the TLR system, histamines trigger the TLR expression by stimulating interferon-γ (IFN-γ to up-regulate mast cells and by stimulating receptor-interacting protein (RIP to activate IκB kinase-β. Contrastingly, antihistamines suppress TIR-domain-containing adaptor protein inducing IFN-β (TRIF and RIP protein and thus inhibit the expression of TLR. In addition, several studies indicated that H1-antihistamines inhibit the IL and TLR systems indirectly.

  14. Prevalence and socioeconomic associations of asthma and allergic rhinitis in northern [corrected] Africa.

    Science.gov (United States)

    Georgy, V; Fahim, H I; El-Gaafary, M; Walters, S

    2006-10-01

    The aims of the current study were to ascertain the prevalence of asthma and allergic rhinoconjunctivitis symptoms in Cairo, Egypt (northern Africa), and to elucidate the socioeconomic factors associated with symptom prevalence and severity. A translated and adapted version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was distributed to a sample of 2,645 11-15-yr-olds in state and fee-paying schools in Cairo. The overall prevalences of wheeze ever, wheeze during the last year and physician-diagnosed asthma were 26.5% (697 out of 2,631), 14.7% (379 out of 2,570) and 9.4% (246 out of 2,609), respectively. The prevalence of rhinoconjunctivitis was 15.3% (399 out of 2,616). Asthma symptoms were independently associated with attendance at a state school, parental asthma, age, history of rhinitis and owning a pet cat. Rhinoconjunctivitis was independently associated with attendance at a state school, father's education, parental history of asthma, asthma symptoms and owning a pet cat. In spite of a higher prevalence of severe asthma symptoms in state schools prevalence of physician diagnosis of asthma was the same in both school types, suggesting inequalities in access to healthcare. In conclusion, the prevalence of physician-diagnosed asthma in Cairo was 9.4%, while the prevalence of rhinoconjunctivitis was 15.3%. There is a higher prevalence and increased severity of asthma symptoms in children of lower socioeconomic groups, as defined by state school attendance in Cairo.

  15. [Annual change of the pet in allergic patients home for ten years].

    Science.gov (United States)

    Maeda, Y; Kudoh, M; Tomita, S; Hasegawa, M; Akiyama, K

    1999-01-01

    There are only few paper in Japan which reports the prevalence of pet keepers in the allergic population and also of the type of pets they keep. We made investigation on these points in 1337 allergic patients employing a questionnaire. Among 1337 patients, allergic conjunctivitis patients were found in 67, eczema patients in 118, allergic rhinitis patients in 368 and bronchial asthmatic patients in 1043. These number contained those who overlapped in symptoms. Approximately 43% of allergy patients are currently keeping the pet at present while 11.2% of the patient had kept the pet in the past. There were two peaks in the age when they began to keep a pet, 6 to 12 and 30 to 40 years of age. Trend in the past decade showed that both the dog and cat bred in foreign countries were increasing. About 80% of patients who own the foreign bred dogs keep them indoor. This ratio is increasing gradually. Another conspicuous change is the sharp increase in those who keep hamsters which occupied 20% of all the pet keeper in 1997. Percentages of the patient who recognizes the aggravation of their symptoms in eye, nose, skin and also as asthma often pet keeping is a about 10%. One out of 4 patients who keep the pet has a family member with rhinitis and/or asthma. We concluded that too many of the allergic patients keep the pet against their benefit and they must be informed that the pet could be the cause of allergy symptoms.

  16. Expression and clinical significance of serum IL-27,IL-17,and IL-10 in patients with allergic rhinitis%变应性鼻炎患者血清中IL-27、IL-17、IL-10的表达及意义

    Institute of Scientific and Technical Information of China (English)

    蔡业海

    2015-01-01

    Objective To investigate the expression and significance of interleukin-27(IL-27),interleukin-17(IL-17)and interleukin-10(IL-10)in serum in the patients with allergic rhinitis(AR). Methods From May 2013 to May 2014,40 patients with allergic rhini-tis( AR group) and 40 cases with non-allergic rhinitis( NAR group) and 40 healthy( health control group) were collected by symptoms, signs,skin prick tests(SPT)and specific IgE(sIgE). According to the visual analogue scale(VAS)score,the nasal symptoms of AR and NAR were evaluated. The expression of I-L27,IL-17 and IL-10 in serum were detected by the enzyme linked immunosorbent assay (ELISA). Results There was no statistical difference between AR and NAR group in nasal symptoms(P>0. 05). In serum,IL-27 and IL10 reduced in AR group and NAR group when compared to health control group(P>0. 05),while IL-17 increased in AR group and NAR group(P>0. 05). In serum,IL-27 and IL-10 reduced in AR group when compared to NAR group(P>0. 05),while IL-17 increased in AR group(P>0. 05). In the AR group,there was negative correlation between IL-27 and IL-17 levels(r=-0. 298),and positive correlation between the IL-27 and IL-10 levels(r=0. 378),and no correlation between IL-17 and IL-10 levels(r= -0. 229). Conclusion IL-27 may have the immunomodulatory effects on IL-10 and IL-17 in patients with allergic rhinitis.%目的:探讨变应性鼻炎患者血清中IL-27、IL-17、IL-10的表达及意义。方法选取2013年5月至2014年5月我院收治的变应性鼻炎( AR)患者40例为AR组,非变应性鼻炎( NAR)患者40例为NAR组,健康人40例为对照组,所有研究对象均进行皮肤点刺试验(SPT)和血清特异性IgE(sIgE)检测。对AR组和NAR组患者进行鼻部症状的视觉模拟量表评分( VAS)。采集3组参与者的外周血,用酶联免疫吸附试验法( ELISA)检测血中IL-27、IL-17、IL-10表达水平,并进行比较。结果 AR组和NAR组患者鼻部症状VAS评分比较,差异无统计学意义(P>0.05)

  17. Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

    Institute of Scientific and Technical Information of China (English)

    Cheng ZHOU; Xiao-dong KANG; Zhi CHEN

    2008-01-01

    It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Thl/Tn2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoides farinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that' IFN-γ released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.

  18. 变应性鼻炎相关危险因素的Logistic回归分析%Logistic regression analysis of related risk factors in allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    冯婷; 黄世铮; 鲁航

    2015-01-01

    目的:探讨变应性鼻炎致病的相关因素。方法通过系统抽样方法选取200例变应性鼻炎患者与200例健康体检者,详细记录每例试验者的体育锻炼、饮食习惯、有变应性鼻炎家族史、吸烟史、工作环境粉尘情况、营养状态、晾晒被褥、花粉过敏、每日睡眠、尘螨过敏、养宠物史、食物过敏、开窗通风等情况,采用Logistic回归分析变应性鼻炎致病的相关因素。结果体育锻炼、营养状况、每日睡眠、饮食习惯与变应性鼻炎无相关性,晾晒被褥、开窗通风及空调开放为变应性鼻炎的保护因素,有变应性鼻炎家族史、吸烟史、花粉过敏、尘螨过敏、养宠物史、食物过敏为变应性鼻炎的危险因素。结论有变应性鼻炎家族史、吸烟史、花粉过敏、尘螨过敏、养宠物史、食物过敏是变应性鼻炎的危险因素。%Objective To investigate the factors related to allergic rhinitis disease. Method Chose 200 cases of allergic rhinitis and 200 cases of healthy people through systematic sampling method, detail recorded each case with the physical exercise, diet habit, family history, smoking history, work environment of dust, status, airing quilts, pollen allergy, daily sleep, dust mite allergy history, pet history, food allergies, ventilation windows, used Logistic regression analysis of factors related to allergic rhinitis. Result Physical exercise, nutrition, sleep, diet were not associated with allergic rhinitis, airing quilts, window ventilation and air conditioning open indicated that were protective factors, the rest of family history, smoking history of allergic rhinitis, allergic to pollen, dust mites allergic, pet history and food allergies were risk factors for allergic rhinitis. Conclusion Family history, smoking history, pollen allergy, dust mite allergy, pet history, food allergies are the risk factors of allergic rhinitis.

  19. 四川宜宾、云南昭通及部分长江上游地区变应性鼻炎患者的变应原分布特点及结果分析%Distribution characteristics of allergens in patients with allergic rhinitis in Yibin, Zhaotong and some areas of the Changjiang River

    Institute of Scientific and Technical Information of China (English)

    王建洪; 黄榆岚; 王仁君; 李雪梅; 杨红梅; 万林

    2016-01-01

    目的:通过对四川宜宾、云南昭通及部分长江上游地区变应性鼻炎患者行变应原检测及分析,筛查本地区常见变应原,了解常见吸入性变应原的分布情况,为临床诊断和治疗变应性鼻炎提供参考。方法采集2013年3月~2015年6月于四川省宜宾市第一人民医院就诊的661例经皮肤点刺试验(skin prick test,SPT)诊断明确的常年性变应性鼻炎患者的资料,对所测定的致敏变应原进行统计分析。结果在661例患者的SPT中,阳性率最高前5位为粉尘螨(76.55%)、屋尘螨(72.01%)、蟑螂(35.85%)、猫毛(11.35%)、狗毛(8.62%);不同季节变应原阳性率差异无统计学意义(χ2=4.568,P=0.206);随着年龄的增加,变应性鼻炎患者变应原阳性率呈下降趋势。结论四川宜宾、云南昭通及部分长江上游地区中导致变应性鼻炎的变应原占主导地位的为粉尘螨、屋尘螨、蟑螂,对于儿童的变应性鼻炎防控应尤为重视。%OBJECTIVETo screen the allergens in patients with allergic rhinitis (AR) in Yibin, Zhaotong and some areas of the Changjiang River, and to study the distribution characteristics of inhaled allergens. METHODSThe clinical data of 661 patients with allergic rhinitis who diagnosed by skin prick test from March 2013 to June 2015 in the First people's Hospital of Yibin City were studied.RESULTSIn 661 patients, the top 5 allergens and their positive rates of skin prick test were Dermatophagoides farinae (76.5%), house dust mites (72.01%), Roach (35.85%), cat hair (11.35%) and dog hair (8.62%) respectively. There were no statistical difference of the positive rates of allergens among different seasons (χ2=4.568, 0.206). With the increasing age of the patients, the positive rate of allergens was decreased. CONCLUSION The dominated allergens in patients with AR are dust mites, house dust mites and cockroaches in Yibin, Zhaotong and and some areas of the

  20. Seasonal changes in nasal cytology in mite-allergic patients

    Directory of Open Access Journals (Sweden)

    Gelardi M

    2014-03-01

    Full Text Available Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs are a major cause of allergic rhinitis (AR and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens

  1. Precision medicine in patients with allergic diseases

    DEFF Research Database (Denmark)

    Muraro, Antonella; Lemanske, Robert F; Hellings, Peter W

    2016-01-01

    of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction...... their translation into pathway-specific diagnostic tests. Wide consensus between academia, governmental regulators, and industry for further development and application of precision medicine in management of allergic diseases is of utmost importance. Improved knowledge of disease pathogenesis together with defining...... validated and qualified biomarkers are key approaches to precision medicine....

  2. Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.

    Science.gov (United States)

    Kawamoto, Yoshiyuki; Ueno, Yuki; Nakahashi, Emiko; Obayashi, Momoko; Sugihara, Kento; Qiao, Shanlou; Iida, Machiko; Kumasaka, Mayuko Y; Yajima, Ichiro; Goto, Yuji; Ohgami, Nobutaka; Kato, Masashi; Takeda, Kozue

    2016-01-01

    The incidence of allergies has recently been increasing worldwide. Immunoglobulin E (IgE)-mediated hypersensitivity is central to the pathogenesis of asthma, hay fever and other allergic diseases. Ginger (Zingiber officinale Roscoe) and its extracts have been valued for their medical properties including antinausea, antiinflammation, antipyresis and analgesia properties. In this study, we investigated the antiallergic effects of ginger and 6-gingerol, a major compound of ginger, using a mouse allergy model and primary/cell line culture system. In mice with ovalbumin (OVA)-induced allergic rhinitis, oral administration of 2% ginger diet reduced the severity of sneezing and nasal rubbing by nasal sensitization of OVA and suppressed infiltration of mast cells in nasal mucosa and secretion of OVA-specific IgE in serum. 6-Gingerol inhibited the expression of not only Th2 cytokines but also Th1 cytokines in OVA-sensitized spleen cells. Accordingly, 6-gingerol suppressed in vitro differentiation of both Th1 cells and Th2 cells from naïve T cells. In addition, 6-gingerol suppressed both superantigen staphylococcal enterotoxin B (SEB)- and anti-CD3-induced T cell proliferation. 6-Gingerol also abrogated PMA plus ionomycin- and SEB-induced IL-2 production in T cells, suggesting that 6-gingerol affected T cell receptor-mediated signal transduction rather than the antigen-presentation process. Indeed, 6-gingerol inhibited the phosphorylation of MAP kinases, calcium release and nuclear localization of c-fos and NF-κB by PMA and ionomycin stimulation. Thus, our results demonstrate that 6-gingerol suppresses cytokine production for T cell activation and proliferation, thereby not causing B cell and mast cell activation and resulting in prevention or alleviation of allergic rhinitis symptoms.

  3. Effects of antiallergic herbal agents on cystic fibrosis transmembrane conductance regulator in nasal mucosal epithelia of allergic rhinitis rabbits

    Institute of Scientific and Technical Information of China (English)

    LI Qiang; LI Xiao-li; YANG Xue; BAO Jian-min; SHEN Xiao-hong

    2009-01-01

    Background It has been found that the expression of cystic fibrosis transmembrane conductance regulator (CFTR) is closely related to allergic rhinitis (AR). In the previous study, we have demonstrated that antiallergic herbal agents (AHA) can obviously inhibit the allergic reaction of AR. The aim of this study was to explore the expression of CFTR and the effects of AHA on CFTR to improve the allergic reaction of AR.Methods An animal model of an AR rabbit was established using ovalbumin (OVA). The rhinitis rabbits were randomly assigned to three groups: AHA treating group (AHATG), modeling group (MG) and healthy controlling group (HCG). The expressions of CFTR protein were examined by immunohistochemical method. The mucosal epithelial cells of all the rabbits were primarily cultured with tissue culture method in vitro and treated with or without glibenclamide for 24 hours. The levels of monocyte chemotactic factor-1 (MCP-1) and RANTES protein in supernatants of culture were measured by ELISA, and the expressions of CFTR mRNA were detected by real-time PCR.Results The expressions of CFTR mRNA and protein greatly increased in mucosal epithelial cells of MG. The protein concentrations of MCP-1, RANTES in culture supernatants of MG were significantly higher than those in the other two groups (P0.05).Conclusions AHA can inhibit the secretions of CFTR, RANTES and MCP-1 in mucosal epithelia and improve inflammatory reaction of AR. CFTR may play an important role in the secretion of RANTES and mucosal inflammatory response in AR. Glibenclamide can inhibit the CFTR secretion in mucosal epithelial cells, in particular during AR process. These effects of glibenclamide on secretion of RANTES can be effectively strengthened by AHA.

  4. Anti-Interleukin-1 Beta/Tumor Necrosis Factor-Alpha IgY Antibodies Reduce Pathological Allergic Responses in Guinea Pigs with Allergic Rhinitis.

    Science.gov (United States)

    Wei-Xu, Hu; Wen-Yun, Zhou; Xi-Ling, Zhu; Zhu, Wen; Li-Hua, Wu; Xiao-Mu, Wu; Hui-Ping, Wei; Wen-Ding, Wang; Dan, He; Qin, Xiang; Guo-Zhu, Hu

    2016-01-01

    This study aims to determine whether the combined blockade of IL-1β and TNF-α can alleviate the pathological allergic inflammatory reaction in the nasal mucosa and lung tissues in allergic rhinitis (AR) guinea pigs. Healthy guinea pigs treated with saline were used as the healthy controls. The AR guinea pigs were randomly divided into (1) the AR model group treated with intranasal saline; (2) the 0.1% nonspecific IgY treatment group; (3) the 0.1% anti-TNF-α IgY treatment group; (4) the 0.1% anti-IL-1β IgY treatment group; (5) the 0.1% combined anti-IL-1β and TNF-α IgY treatment group; and (6) the fluticasone propionate treatment group. The inflammatory cells were evaluated using Wright's staining. Histopathology was examined using hematoxylin-eosin staining. The results showed that the number of eosinophils was significantly decreased in the peripheral blood, nasal lavage fluid, and bronchoalveolar lavage fluid (P guinea pigs. The data suggest that topical blockade of IL-1β and TNF-α could reduce pathological allergic inflammation in the nasal mucosa and lung tissues in AR guinea pigs.

  5. Analysis of Detecting Aeroallergen Specific IgE and IgE Level of Patients with Allergic Rhinitis in Nanjing%南京地区变应性鼻炎患者吸入性变应原特异性IgE和总IgE的检测分析

    Institute of Scientific and Technical Information of China (English)

    王艾丽; 严孝岭; 刘国瑞; 李梅; 虞伟

    2012-01-01

    目的 检测和分析不同年龄变应性鼻炎(AR)患者血清总IgE水平和吸入性变应原分布特点.方法 采用速率散射比浊法和免疫印迹法分别检测351例(三组)不同年龄(4~16岁,17~40岁和≥41岁)患者血清中总IgE水平和吸入性变应原特异性IgE抗体.结果 4~16岁AR患者血清总IgE增高率(77.31%)及水平(488.31±341.41 IU/ml)显著高于其他两组患者结果(63.1%,368.42±336.62 IU/ml,P<0.01和40.0%,287.54±315.06 IU/ml,P<0.001).351例AR患者特异性IgE抗体-吸入性变应原分布率依次为:屋尘螨(81.48%)、粉尘螨(81.2%)、动物毛发(猫/狗)(38.46%)、蟑螂(25.36%)、花粉组合(13.11%),艾蒿(11.97%)、矮豚草(11.11%)、悬铃树(7.12%)、霉菌组合(6.27%)和桦树(1.14%).结论 少儿患者组血清中总IgE水平和对粉尘螨、屋尘螨、动物毛发过敏的比例显著升高.40岁以上患者组免疫功能减低可能影响总IgE产生.诱发该地区不同年龄组AR的主要过敏原(阳性率超过20%以上)是粉尘螨、屋尘螨、动物毛发(猫/狗)和蟑螂.%Objective To detect the IgE level and aeroallergen specific IgE in order to analyze the characteristic in allergic rhinitis patients of different age. Methods Serum aeroallergen specific IgE antibody and IgE level of patients were detected by velocity scatter nephelometry and immunoblotting. 351 serum samples velocity scatter nephelometry and immunoblotting. 351 serum samples of patients were stratified three age groups :4~ 16 years> 17~40 years old and greater than 40 years old. Results The total IgE positive rate (77. 31%) and IgE level(488. 31 ± 341. 41 IU/ml) in 4~16 years group were significantly higher than that two groups (368. 42 ± 336. 62 IU/ml and 287. 54 ± 315. 06 IU/ml, P<0. 01 and 0. 001). The positive rate of aeroallergen specific IgE antibody in 351 patients serum with allergic rhinitis in order were dermatophagoides pteron-yssinus (81. 48

  6. 三伏灸与普通穴位贴敷对变应性鼻炎患者临床表现改善情况的比较研究%A Comparative Study on Dog-day Moxibustion and General Acupoint Application in Clinical Presentation of Allergic Rhinitis Patients

    Institute of Scientific and Technical Information of China (English)

    王宁宁; 陈静; 陈俊琦; 邓桂珠; 胡楠; 江晓宇; 王升旭

    2012-01-01

    Objective: Compare and observe the improvement of the clinical signs and symptoms of the allergic rhinitis patients in the treatment of dogday moxibustion and general acupoint application. Methods: Choose sixty cases of allergic rhinitis patients and divide them into 2 groups according to the table of random numbers. 30 of them are in the dogday moxibustion group ( DDM group ) , and 30 of them are in the general acupoint application group (GAA group). The two groups were selected Zhang' s moxibustion prescription, selected DU14,BL12, BL13 and other points. The DDM group from July 9th,2010,in the dog day during treatment;the GAA group from June 1st,2010,during the non - dog day moxibustion treatment. Patients in both groups were stuck for 10 days,5 times for a course of treatment. Before treatment,after treatment and after six months follow -up,by the ENT specialist on the basis of symptoms, signs, grading scoring criteria scale evaluation. Observe the improvement of their clinical presentation. Results:①Compared with the same group before treatment score,in addition to DDM group nasal mucosa color scores after treatment, as well as the symptoms of runny score in the followup six months after the previous differences( P > 0. 05) , the rest of scores were decreased (P 0. 05 ).②Compared with the GAA group, DDM group was clear nasal discharge symptoms after six months follow - up, the lower the score the amplitude was small(P 0. 05) Conclusion: For the improvement of the clinical manifestations of patients with allergic rhinitis, the general acupoint application and the clinical efficacy of the dogday moxibution are almost the same. Available at the time of the non - dogday of moxibution, including the acute phase of the disease, to promote zhang' s moxibustion prescription so as to effectively improve the clinical manifestations.%目的:比较三伏灸和普通穴位贴敷对变应性鼻炎患者的临床症状和体征的改善情况.方法:60例变应性鼻炎

  7. Influence of fluticasone Propionate and desloratadine citrate disodium on the level of EOs,CsF,IL-5 in the serum of allergic rhinitis Patients%丙酸氟替卡松联合枸地氯雷他定治疗对变应性鼻炎患者血清EOS﹑CSF和IL-5水平的影响

    Institute of Scientific and Technical Information of China (English)

    朱立新

    2016-01-01

    Objective To study the influence of fluticasone propionate and desloratadine citrate disodium on the level of EOS,CSF,IL- 5 in the serum of allergic rhinitis patients. Methods One hundred and thirty-six cases of allergic rhinitis were randomly divided into obser-vation group and control group. The observation group was given oral nasal spray and fluticasone propionate nasal spray,desloratadine citrate di-sodium tablets orally. The control group was given desloratadine citrate disodium tablets. The time of treatment was 4 weeks. After the treat-ment,the visual analogue scale(VAS)of nasal symptoms of the patients in two groups were decided. The changes of serum EOS,CSF and IL- 5 levels were compared between the two groups before and after treatment,and the correlation between the three groups was analyzed. Results The total effective rate of the observation group with fluticasone propionate and desloratadine citrate disodium after treatment was 94. 1% ,sig-nificantly higher than that of the control group(77. 9% ). The serum EOS,CSF and IL-5 levels of two groups of patients after treatment were significantly lower than those before treatment. The EOS,CSF and IL-5 levels of observation group were significantly lower than those in the control group( P < 0. 05). The correlation analysis showed that CSF and IL-5 had a positive correlation with EOS( P < 0. 01). Conclusion Fluticasone propionate and desloratadine citrate disodium for the treatment of allergic rhinitis patients can significantly reduce the serum levels of EOS,CSF and IL-5 levels. The CSF,IL-5 and EOS levels are closely related.%目的 探讨丙酸氟替卡松联合枸地氯雷他定治疗对变应性鼻炎患者血清嗜酸粒细胞(EOS)、集落刺激因子(CSF)、白介素(IL)-5水平的影响.方法 选取136例变应性鼻炎患者作为研究对象,随机分为观察组和对照组.观察组给予丙酸氟替卡松鼻喷雾剂喷鼻,枸地氯雷他定片口服,对照组给予枸地氯雷他

  8. A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

    Science.gov (United States)

    Aryan, Zahra; Holgate, Stephen T; Radzioch, Danuta; Rezaei, Nima

    2014-01-01

    Toll-like receptors (TLR) belong to a large family of pattern recognition receptors known as the ancient 'gatekeepers' of the immune system. TLRs are located at the first line of defense against invading pathogens as well as aeroallergens, making them interesting targets to modulate the natural history of respiratory allergy. Agonists of TLRs have been widely employed in therapeutic or prophylactic preparations useful for asthma/allergic rhinitis (AR) patients. MPL® (a TLR4 agonist) and the CpG oligodeoxynucleotide of 1018 ISS, a TLR9 agonist, show strong immunogenicity effects that make them appropriate adjuvants for allergy vaccines. Targeting the TLRs can enhance the efficacy of specific allergen immunotherapy, currently the only available 'curative' treatment for respiratory allergies. In addition, intranasal administration of AZD8848 (a TLR7 agonist) and VTX-1463 (a TLR8 agonist) as stand-alone therapeutics have revealed efficacy in the relief of the symptoms of AR patients. No anaphylaxis has been so far reported with such compounds targeting TLRs, with the most common adverse effects being transient and local irritation (e.g. redness, swelling and pruritus). Many other compounds that target TLRs have been found to suppress airway inflammation, eosinophilia and airway hyper-responsiveness in various animal models of allergic inflammation. Indeed, in the future a wide variability of TLR agonists and even antagonists that exhibit anti-asthma/AR effects are likely to emerge.

  9. Effect of azelastine hydrochloride nasal spray combined with desloratadine to inflammatory factors, cell function and IgE of patients with allergic rhinitis%盐酸氮卓斯汀喷剂联合地氯雷他定对变应性鼻炎患者炎症因子、细胞功能和IgE水平的影响

    Institute of Scientific and Technical Information of China (English)

    饶兴旺; 陈琴娟; 陈晓云; 张悦; 林刃舆; 廖志苏

    2016-01-01

    Objective To explore the effect of azelastine hydrochloride nasal spray combined with desloratadine to inflammatory factors, cell function and IgE of patients with allergic rhinitis.Methods 92 cases of allergic rhinitis patients treated in the first affiliated hospital of wenzhou medical college hospital from June 2014 to December 2015 were divided into experimental group(n=46) and control group(n=46) according to the random number table method.The control group was given oral loratadine tablets, one piece per time, one time per day, while the experimental group was given azelastine hydrochloride nasal spray on the basis of the control group,each nostril one spray, one time in the morning and night.The clinical efficacy of two groups of patients would be observed after 4 weeks,ELISA would be used to detect serum levels of IFN-γ, IL-4, IL-8 and IgE level, and IFN-γ/IL-4 was the value of Thl/Th2,flow cytometry instrument was used to the determination of T cell subgroup CD4 +,CD8 + cells.Results 4 weeks after treatment,stuffy nose, nasal itching, runny nose, sneezing and nasal cavity change points are lower than before the treatment in both the two groups.Experimental group obviously lower than the control group, the difference was statistically significant ( P <0.05 ).The total effective rate of treatment group is higher than the control group,the difference was statistically significant(χ2 =4.389,P=0.036).The serum level of IFN-γis higher than before treatment in both the two groups.IL-4, IL-8 inflammatory factor levels were lower than before treatment,the experimental group was better than control group,the difference was statistically significant(P<0.05).CD4 +,CD8 +of T cells and Thl/Th2 values are higher than before the treatment in both the two groups,the experimental group was higher than control group, the difference was statistically significant ( P<0.05 ).Serum IgE levels were lower than before the treatment in both the two groups,the experimental group

  10. La estria supranuclear de las células ciliadas en la rinitis alérgica Supranuclear stria of ciliated cells in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Ana Zerdiew

    2007-08-01

    Full Text Available Se estudiaron 80 pacientes adultos alérgicos, que cursaron con los siguientes cuadros clínicos: 16 casos de rinitis intermitente y 64 de rinitis persistente. Se realizó el recuento porcentual de la estría supranuclear de las células ciliadas, respecto de los leucocitos presentes en los extendidos obtenidos por toma endonasal. Con los datos obtenidos se clasificaron los extendidos en 4 grupos; Grupo A (N=23: predominio leucocitario eosinófilo con eosinofilia nasal >10%, Grupo B (N=15: abundantes leucocitos neutrófilos y eosinofilia nasal >10%, Grupo C (N=29: con escasos leucocitos, Grupo D (N=13: con abundantes leucocitos de predominio neutrófilo sin eosinofilia. Se observó que el incremento porcentual de estría supranuclear se correlacionó con eosinofilia nasal >10% y con las muestras que presentaron escasos leucocitos. Sin embargo se evidenció una marcada disminución del porcentaje de estría supranuclear en la leucocitosis neutrófila de etiología bacteriana.Nasal secretions were studied in 80 allergic adults patients: 16 with intermittent rhinitis and 64 with persistent rhinitis. The percentage of supranuclear stria of ciliated cells with regard to leucocytes was studied by nasal scraping. Four groups of patients were classified according to nasal leucocytic predominance: patients with eosinophilic predominance with eosinophils > 10% in Group A (N=23, patients with abundant neutrophils and eosinophils >10% in Group B (N=15, patients with scant leucocytes in Group C (N=29, patients with neutrophilic predominance without eosinophils in Group D (N=13. An increase of supranuclear stria percentage was correlated to eosinophils > 10% and also correlated to scant leucocytes. Nevertheless, a significant decrease of supranuclear stria percentage was observed in neutrophilic leukocytosis of bacterial etiology.

  11. 孟鲁司特钠联和氟替卡松鼻喷雾剂治疗变应性鼻炎合并支气管哮喘患者血清C反应蛋白的影响%The influence on serum C reactive protein in patients with allergic rhinitis and bronchial asthma treated by Montelukast sodium and Fluticasone nasal spray

    Institute of Scientific and Technical Information of China (English)

    郭良斌; 江永琴

    2016-01-01

    目的:研究孟鲁司特钠联和氟替卡松鼻喷雾剂治疗变应性鼻炎(AR)合并支气管哮喘患者血清C反应蛋白的影响。方法选取2010年2月~2015年2月我院接诊的100例AR合并支气管哮喘患者作为本次研究对象。按照随机数表法分为观察组和对照组,对照组给予孟鲁司特钠治疗,观察组给予孟鲁司特钠联和氟替卡松鼻喷雾剂治疗,观察两组患者治疗后血清c反应蛋白水平、临床症状和体征消失时间、治疗疗效情况。结果观察组C反应蛋白水平(5.03±1.02)mg/L小于对照组(18.92±3.02)mg/L,差异具有统计学意义(P<0.05);观察组喘憋消失时间、啰音消失时间、咳嗽消失时间、退热时间、住院时间(2.52±0.71、4.56±0.63、6.93±1.31、4.52±1.01、7.53±1.24)d均小于对照组(3.92±1.03、5.80±0.82、10.39±2.04、5.31±1.30、12.49±2.05)d,差异具有统计学意义(P<0.05);观察组总有效率98.00%(49/50)优于对照组80.00%(40/50),差异具有统计学意义(P<0.05)。结论孟鲁司特钠联和氟替卡松鼻喷雾剂治疗AR合并支气管哮喘疗效显著,能够降低c反应蛋白水平。%Objective To investigate the influence on serum C reactive protein in patients with allergic rhinitis and bronchial asthma treated by montelukast sodium and flutica-sone nasal spray. Methods 100 cases of allergic rhinitis with bronchial asthma were enrolled in this study from Febru-ary 2010 to February 2015. According to the random number table,patients were divided into observation group and control group. The control group was treated with montelukast sodi-um,while the observation group was treated with montelukast sodium and fluticasone nasal spray. Serum C reactive protein level,clinical symptoms,signs disappeared time and treat-ment efficacy were observed. Results C reactive protein level in the observation group(5.03±1.02)mg/L was less than that of the control

  12. A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe

    DEFF Research Database (Denmark)

    Christensen, Stine Holmegaard; Timm, Signe; Janson, Christer;

    2016-01-01

    categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models. RESULTS: Livestock farm...... upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.54-0.85] and nasal symptoms (OR 0.82, 0.68-0.99) than city upbringing, and an urban-rural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.88-0.94). Pets in the home at birth (OR 0.78, 0...... upbringing. Pets at birth decreased the risk further, but did not explain the urban-rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findings....

  13. Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition

    Directory of Open Access Journals (Sweden)

    Sallam MA

    2016-05-01

    Full Text Available Marwa Ahmed Sallam, Hala Mahmoud Helal, Sana Mohamed Mortada Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA for the maintenance therapy of allergic rhinitis. The effect of encapsulating TA in different nanocarriers on its mucosal permeation and retention as well as in vivo nasal deposition has been studied. A comparative study was established between polymeric oil core nanocapsules (NCs, lipid nanocarriers such as nanoemulsion (NE, and nanostructured lipid carriers (NLCs. The elaborated nanocarriers were compared with TA suspension and the commercially available suspension “Nasacort®”. The study revealed that NC provided the highest mucosal retention, as 46.14%±0.048% of the TA initial dose was retained after 24 hours, while showing the least permeation through the nasal mucosa. On the other hand, for TA suspension and Nasacort®, the mucosal retention did not exceed 23.5%±0.047% of the initial dose after 24 hours. For NE and NLC, values of mucosal retention were 19.4%±0.041% and 10.97%±0.13%, respectively. NC also showed lower mucosal irritation and superior stability compared with NE. The in vivo nasal deposition study demonstrated that NC maintained drug in its site of action (nasal cavity mucosa for the longest period of time. The elaborated polymeric oil core NCs are efficient carriers for the administration of nasally acting TA as it produced the least permeation results, thus decreasing systemic absorption of TA. Although NCs have been administered via various routes, this is the first study to implement the polymeric oil core NC as an efficient carrier for localized nasal drug delivery. Keywords: allergic rhinitis, nanocapsules, triamcinolone acetonide, nasal mucosa, nasal deposition

  14. Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort.

    Science.gov (United States)

    Maslova, Ekaterina; Strøm, Marin; Oken, Emily; Campos, Hannia; Lange, Christoph; Gold, Diane; Olsen, Sjurdur F

    2013-10-01

    Maternal fish intake during pregnancy may influence the risk of child asthma and allergic rhinitis, yet evidence is conflicting on its association with these outcomes. We examined the associations of maternal fish intake during pregnancy with child asthma and allergic rhinitis. Mothers in the Danish National Birth Cohort (n 28 936) reported their fish intake at 12 and 30 weeks of gestation. Using multivariate logistic regression, we examined the associations of fish intake with child wheeze, asthma and rhinitis assessed at several time points: ever wheeze, recurrent wheeze (>3 episodes), ever asthma and allergic rhinitis, and current asthma, assessed at 18 months (n approximately 22,000) and 7 years (n approximately 17,000) using self-report and registry data on hospitalisations and prescribed medications. Compared with consistently high fish intake during pregnancy (fish as a sandwich or hot meal > or equal to 2-3 times/week), never eating fish was associated with a higher risk of child asthma diagnosis at 18 months (OR 1·30, 95% CI 1·05, 1·63, P=0·02), and ever asthma by hospitalisation (OR 1·46, 95% CI 0·99, 2·13, P=0·05) and medication prescription (OR 1·37, 95% CI 1·10, 1·71, P=0·01). A dose-response was present for asthma at 18 months only (P for trend=0·001). We found no associations with wheeze or recurrent wheeze at 18 months or with allergic rhinitis. The results suggest that high (v. no) maternal fish intake during pregnancy is protective against both early and ever asthma in 7-year-old children.

  15. Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma

    Science.gov (United States)

    Duong-Quy, Sy; Vu-Minh, Thuc; Hua-Huy, Thong; Tang-Thi-Thao, Tram; Le-Quang, Khiet; Tran-Thanh, Dinh; Doan-Thi-Quynh, Nhu; Le-Dong, Nhat-Nam; Craig, Timothy J; Dinh-Xuan, Anh-Tuan

    2017-01-01

    Background The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established. Objective To study the cutoff of nasal FENO in the diagnosis of subjects with AR and AR-asthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics. Methods The study was cross sectional and descriptive. Subjects were grouped into control subjects, AR, and AR-asthma, based on the inclusion criteria. Exhaled NO (nasal FENO, bronchial FENO, and alveolar concentration of NO) was measured by multiple flow electro-luminescence device. Results Six hundred twenty-eight subjects were included: 217 control subjects (children: n=98, 10±4 years; adults: n=119, 50±16 years), 168 subjects with AR (children: n=54, 10±3 years; adults: n=114, 49±15 years), and 243 subjects with AR-asthma (children: n=115, 10±3 years; adults: n=128, 51±14 years). Nasal peak inspiratory flow and peak expiratory flow were lower in subjects with AR and AR-asthma than in control subjects (P<0.01 and P<0.01; and P<0.05 and P<0.01, respectively). Nasal FENO levels were significantly higher in subjects with AR and AR-asthma than in control subjects (1614±629 and 1686±614 ppb vs 582±161 ppb; P<0.001 and P<0.001, respectively). In subjects with AR non-asthma, the cutoffs of nasal FENO for those diagnosed with AR were 775 ppb in children, 799 ppb in adults, and 799 in the general population (sensitivity: 92.68%, 92.63%, and 92.65%, respectively; specificity: 91.67%, 95.00%, and 96.87%, respectively). In subjects with AR-asthma, the cutoffs of nasal FENO were higher, especially in asthma children (1458 ppb; sensitivity: 72.97% and specificity: 95.83%). Conclusion Nasal FENO measurement is a useful technique for the diagnosis of AR

  16. 咪唑斯汀治疗荨麻疹并发过敏性鼻炎的疗效和安全性观察%Therapeutic effect and safety of mizolastine in the treatment of urticaria and allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    朱宇

    2012-01-01

    acute urticaria with allergic rhinitis in the two groups. The total effective rate of chronic urticaria with allergic rhinitis in the control group was lower than that of chronic urticaria with allergic rhinitis in the observation group. ③xerostomia occurred in two patients in the observation group; while in the control group headache in one patient, drowsiness in three patients, xerostomia in two patients. The two groups of patients showed significantly different rates of adverse reactions (P < 0.05). ④The patient's satisfaction of the observation group was significantly higher. Conclusion: Mizolastine shows good therapeutic effect in the treatment of acute /chronic urticaria with allergic rhinitis, with mild adverse reactions (no drowsiness), and high clinical safety.

  17. Pathological conditions associated with rhinitis medicamentosa

    Directory of Open Access Journals (Sweden)

    Milošević Dušanka

    2004-01-01

    Full Text Available Rhinitis medicamentosa (nose-drop-nose" is a term used for pathological condition of the nasal mucous membrane that results from long-term abuse with intranasal vasoconstrictors. The aim of this work was to examine what lead the patients with nosedropnose rhinitis to the initial usage of intranasal vasoactive drugs, in this prospective study, 92 patients with rhinitis medicamentosa were included. The evaluation of all study subjects comprised the history, ORL, microbiological and radiological examination, skin prick tests with a battery of routine respiratory and nutritive allergens and nasal cytology. The results of this study showed that the pathological conditions for initial use of intranasal vasoactive drugs were: acute upper respiratory infections in 293%, vasomotor rhinitis in 21.7%, allergic rhinitis in 16.3%, deviated nasal septum in 13.0%, nasal polyposis in 12%, rhinitis induced by mechanical trauma in 4.4%, and hormonal rhinitis in 3.3% of patients with rhinitis medicamentosa. In conclusion, the most common pathological conditions for developing rhinitis medicamentosa were chronic inflammatory and structural diseases manifested by permanent nasal obstruction as well as acute upper respiratory infections are.

  18. Rinite alérgica: aspectos epidemiológicos, diagnósticos e terapêuticos Allergic Rhinitis: epidemiological aspects, diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Cássio da Cunha Ibiapina

    2008-04-01

    Full Text Available Este estudo tem como objetivo revisar a literatura a respeito da rinite alérgica quanto aos aspectos epidemiológicos, clínicos, diagnósticos e terapêuticos. A revisão da bibliografia foi realizada utilizando-se as bases de dados Medline, Literatura Latino-Americana e do Caribe em Ciências da Saúde e HighWire, nos últimos trinta anos, utilizando-se os descritores allergic rhinitis, epidemiology, diagnosis, e treatment. Foram selecionados 60 artigos. Este estudo destaca o aumento na prevalência da rinite alérgica, sua associação com a asma, os critérios diagnósticos e seu tratamento. A classificação da rinite alérgica é apresentada, bem como as estratégias de tratamento. As modalidades terapêuticas apresentadas e discutidas são anti-histamínicos, corticóides, imunoterapia, antileucotrienos, cromoglicato dissódico e anticorpos anti-IgE, bem como a redução da exposição aos alérgenos. Finalmente, ressalta-se a importância da abordagem da rinite alérgica em saúde pública.This study was a review of the literature on the epidemiological, clinical, diagnostic and therapeutic aspects of allergic rhinitis. Bibliographic searches were based on the information contained within the Medline, Latin American and Caribbean Health Sciences Literature and HighWire databases, covering the last thirty years and using the following search terms: 'allergic rhinitis', 'epidemiology', 'diagnosis' and 'treatment'. Sixty articles were selected. This study describes the increase in the prevalence of allergic rhinitis, its relationship with asthma, the diagnostic criteria and the treatment. The classification of allergic rhinitis and strategies for its treatment are presented. Therapeutic modalities presented and discussed include the administration of antihistamines, corticosteroids, immunotherapy, anti-leukotrienes, sodium cromoglycate and anti-IgE antibodies, as well as minimizing exposure to inhaled allergens. Finally, the importance of

  19. Effect of RNA interference therapy on the mice eosinophils CCR3 gene and granule protein in the murine model of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    Xin-Hua Zhu; Bing Liao; Ke Liu; Yue-Hui Liu

    2014-01-01

    Objective:To observe the clinical manifestations of allergic rhinitis mice and the expression changes of the eosinophilsCCR3 and the granule protein mRNA in the bone marrow, peripheral blood and nasal lavage fluid.Methods:Twenty-fourBALB/c mice were randomly divided into the control group,PBS therapy group, siRNA therapy group and theCCR3 siRNA therapy group (n=6).Allergic rhinitis model were sensitized and stimulated by ovalbunfin, andCCR3 siRNA therapy group were administered withCCR3 transnasally before stimulated.The levels of the eosinophilsCCR3,MBP,ECP andEPO in bone marrow, peripheral blood and nasal lavage fluid were detected byRT-PCR.Results:Compared to the control group andCCR3 siRNA therapy group, the nasal mucosa of thePBS therapy group and siRNA therapy group developed epithalaxy, goblet cells hyperplasia, squamous epithelium metaplasia, epithelium necrosis, lamina propria and submucosa gland hyperplasia, vasodilatation, tissue edema, and the characterized eosinophil infiltration.RT-PCR indicated that theCCR3 mRNA,MBP ,ECP andEPO expression in bone marrow, peripheral blood and nasal lavage fluid of theCCR3 siRNA therapy group was lower than thePBS therapy group andsiRNA therapy group(P<0.05).Conclusions:TheRNA interference therapy toCCR3 by local administration pernasal can suppress the process of the development, migration and invasion of the allergic rhinitis eosinophil, thus can reduce the effect of eosinophils and then reduce the inflammation effect of the allergic rhinitis.It may be a new treatment for respiratory tract allergic inflammation.

  20. Obesity is a risk factor for allergic rhinitis in children of Wuhan (China)

    OpenAIRE

    Lei, Yang; Yang, Huang; Zhen, Long

    2016-01-01

    Background The relationship between obesity and allergic diseases in children of China is unclear. Objective To analysis the relationship between obesity and overweight and the prevalence of allergic diseases and the impact of gender. Methods Questionnaire based on those used in National Study of Asthma and Allergies in Childhood in China. The study included 3,327 participants (23.7% aged 2–6 years, 65.8% aged 7–12 years, 10.5% aged 13–14 years) in Wuhan City. Allergic diseases were determine...

  1. Calidad de vida en pacientes con rinitis alérgica: estudio comparativo con la hipetensión arterial en el ámbito de atención primaria Quality of life in patients with allergic rhinitis: comparative study with hypertension in primary care

    Directory of Open Access Journals (Sweden)

    B. de la Hoz

    2009-08-01

    ón de CVRS es similar en pacientes con RA e HTA, a pesar de que los pacientes con RA muestran, significativamente, una mayor afectación de las actividades cotidianas. La frecuente comorbilidad de los pacientes con RA obliga a evaluar la presencia de otras patologías alérgicas especialmente el asma.Background. This study was conducted to determine the impact of allergic rhinitis (AR on health-related quality of life in patients in primary care. Methods. Observational, cross-sectional, multicentre study that included a national sample of patients consulting general practitioners for AR. Patients consulting for Hypertension were studied as a control sample. A general activities questionnaire, the mini Rhino conjunctivitis Quality of Life Questionnaire (mini-RQLQ and the Medical Outcome Short-Form (SF-12 were employed. Results. A total of 133 general practitioners and 1,309 patients were included, 1,093 (83.56% patients were diagnosed as AR and 215 (16.44 as Hypertensive. Adjustments were made for age and gender. The effect of AR on daily activities was noteworthy; the impairment in activities in relationship with sport, work, driving cars and entertainment was higher in AR than in patients with hypertension, with statistical differences. Both diseases, AR and hypertension, had a moderate impact on SF-36 physical and mental summary scores, without statistical significance. Adjusted sex and age were PCS12: (AR: 54.2± 19.30; hypertension 57.6 ± 22.01, p=0.075 and MCS12:(AR: 56.9±19.70; hypertension 58.8 ±19.82, p=0.330, without statistical significance. Patients with AR showed an impact in all domains of mini-RQLQ and the severity of disease according mini-RQLQ score had a good correlation with the impairment of daily activities. 76.7% of patients with AR had a coexistent atopic disease (asthma, conjunctivitis, atopic dermatitis as well as a disease in relationship with rhinitis (sinusitis, upper and lower airway infections.... Asthma has been the disease more

  2. Effect of antiallergic herbal agents on chloride channel-3 and immune microenvironment in nasal mucosal epithelia of allergic rhinitis rabbits

    Institute of Scientific and Technical Information of China (English)

    WANG Li-feng; XU Li-juan; GUO Feng-hua; WANG Li-na; SHEN Xiao-hong

    2010-01-01

    Background Allergic rhinitis (AR) is a Th2 dominant cytokine response. Chloride channel-3 (CIC-3) plays an important role in nasal mucosal edema and inflammatory pathologic changes in AR. Antiallergic herbal agents (AHA) are antiallergic herbal products. In the previous study, we have demonstrated that AHA clearly inhibited allergic medium and relieved allergic reaction of AR. The aim of this study was to evaluate the function of CIC-3 and discuss the possible therapeutic effects of AHA on immune microenvironment in AR.Methods AHA were produced and used to treat AR. An animal model of an AR rabbit was established by ovalbumin (OVA). The rhinitis rabbits were randomly divided into three groups: AHA treated group (AHATG), model group (MG) and healthy control group (HCG). The expressions of CIC-3 protein were examined by immunohistochemical method. The mucosal epithelial cells of all the rabbit groups were primarily cultured with tissue culture method in vitro with or without rhlL-4 or rhlL-2. Furthermore, the expressions of CIC-3 mRNA were detected by real-time PCR. The levels of monocyte chemotactic factor-1 (MCP-1) and vascular cell adhesion molecule-1 (VCAM-1) protein in culture supernatants were measured by ELISA.Results The expressions of CIC-3 mRNA increased more in mucosal epithelial cells of MG than those in AHATG and HCG (P0.05).Conclusions AHA can inhibit the secretions of CIC-3, MCP-1 and VCAM-1 in mucosal epithelia and improve inflammatory reaction of AR. CIC-3 plays an important role in the secretion of cytokines and mucosal inflammatory response in AR. RhlL-4 can enhance the secretion of CIC-3, MCP-1 and VCAM-1 in mucosal epithelial cells, especially during the AR process. These enhanced effects of rhlL-4 were significantly suppressed by AHA. The secretions of CIC-3, MCP-1 and VCAM-1 can not be induced obviously by rhlL-2 in mucosal epithelial cells in AR.

  3. Non-invasive sampling methods of inflammatory biomarkers in asthma and allergic rhinitis

    NARCIS (Netherlands)

    Boot, Johan Diderik

    2009-01-01

    In this thesis, a series of clinical studies have been described, in which we applied, evaluated or modified novel and existing non- or semi-invasive sampling methods and detection techniques for the assessment of biomarkers in allergic airway inflammation.

  4. Effect of Air Pollutants on Allergic Rhinitis in Beijing%北京市空气污染物对过敏性鼻炎的影响研究

    Institute of Scientific and Technical Information of China (English)

    张凤英; 王五一; 徐进; 梁莺; 黄魏宁

    2011-01-01

    To investigate the effect of the global environment change on urbanization and health, daily numbers of persons consulting general practitioners for allergic rhinitis ( AR) between March 19th 2009 and March 18th 2010 were obtained from Department of Otolaryngology-Head and Neck Surgery, Beijing Hospital, Ministry of Public Health.Data of atmospheric concentrations of PM10, NO2 and sulfur dioxide SO2 were collected.The relationship between concentration of air pollutants and the number of outpatients and emergency for allergic rhinitis in Beijing was studied.The results showed that the number of both male patients and female patient has the same increasing trends with the age.About 74.34% of the patients were 21 to 50 years.Spring and autumn had a higher morbidity of AR than summer and winter.The number of medical consultations for allergic rhinitis was correlated with the three air pollutants during March 19th 2009 to September 18th 2009, showed that the air pollutants had short-term effects on allergic rhinitis, exacerbating symptoms and increasing hospital admissions.%以2009年3月19日至2010年3月18日间北京医院耳鼻喉-头颈外科的过敏性鼻炎(AR)门诊就诊病人观测为基础,结合北京市空气质量,探讨空气质量与AR的关系.结果表明,AR患者的人数均随年龄的增长呈现先增加后减少的趋势,以中青年龄段(21~50岁)人数最多.春、秋季是过敏性鼻炎的易发时期,夏、冬季发病率相对较低.AR日就诊人数的时间变化趋势与空气中PM10,SO2,NO2的浓度变化具有一定的时间对应性,在观测的上半期内尤为明显,表明在短期内空气中PM10,SO2,NO2浓度的增加会直接影响AR的发生与症状加重,并导致就诊人数增加.

  5. Observation of clinical efficacy of low-intensity laser irradiation in treatment of allergic rhinitis%低强度激光照射治疗变应性鼻炎的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    倪伟鹏

    2013-01-01

    Objective To analyze and evaluate the efficacy and safety of low-intensity laser irradiation in the treatment of allergic rhinitis. Methods 128 patients with allergic rhinitis (AR) admitted to our hospital were randomly divided into the treatment group and the control group and received the low-intensity laser irradiation treatment and the intranasal corticosteroid nasal spray treatment respectively.The efficacy of the two groups was compared. Results The differences between the treatment group and the control group were not statistically significant (P >0.05). Conclusion For patients with allergic rhinitis, the low-intensity laser nasal irradiation treatment is a safe and effective method of treatment;The intranasal application of corticosteroid is a recommended therapy for allergic rhinitis and the low-intensity laser nasal irradiation can be used as an adjuvant therapy.%  目的分析并评价低强度激光照射治疗变应性鼻炎的疗效及安全性。方法将我院收治的128例变应性鼻炎(AR)患者随机均分成治疗组和对照组,分别采用低强度激光照射治疗和鼻内应用糖皮质激素喷鼻治疗,比较两组疗效。结果治疗组与对照组对比差异无统计学意义(P>0.05)。结论对变应性鼻炎患者进行低强度激光鼻腔照射治疗是一种安全、有效的治疗方法;鼻内应用糖皮质激素是变应性鼻炎的推荐疗法,低强度激光鼻腔照射治疗可作为辅助治疗。

  6. Multiple grass mixes as opposed to single grasses for allergen immunotherapy in allergic rhinitis.

    Science.gov (United States)

    Gangl, K; Niederberger, V; Valenta, R

    2013-11-01

    Grass pollen allergy affects approximately 40% of allergic patients. Subcutaneous allergen immunotherapy (SCIT) is the only allergen-specific and disease-modifying treatment available. Currently available therapeutic vaccines for the treatment of grass pollen allergy are based on natural grass pollen extracts which are either made from pollen of one cross-reactive grass species or from several related grass species. Clinical studies have shown that SCIT performed with timothy grass pollen extract is effective for the treatment of grass pollen allergy. Moreover, it has been demonstrated that recombinant timothy grass pollen allergens contain the majority of relevant epitopes and can be used for SCIT in clinical trials. However, recent in vitro studies have suggested that mixes consisting of allergen extracts from several related grass species may have advantages for SCIT over single allergen extracts. Here, we review current knowledge regarding the disease-relevant allergens in grass pollen allergy, available clinical studies comparing SCIT with allergen extracts from timothy grass or from mixes of several related grass species of the Pooideae subfamily, in vitro cross-reactivity studies performed with natural allergen extracts and recombinant allergens and SCIT studies performed with recombinant timothy grass pollen allergens. In vitro and clinical studies performed with natural allergen extracts reveal no relevant advantages of using multiple grass mixes as opposed to single grass pollen extracts. Several studies analysing the molecular composition of natural allergen extracts and the molecular profile of patients' immune responses after SCIT with allergen extracts indicate that the major limitation for the production of a high quality grass pollen vaccine resides in intrinsic features of natural allergen extracts which can only be overcome with recombinant allergen-based technologies.

  7. 青岛市儿童支气管哮喘合并变应性鼻炎问卷调查分析%CHILDREN WITH BRONCHIAL ASTHMA COMPLICATED WITH ALLERGIC RHINITIS IN QINGDAO: A QUESTIONNAIRE INVESTIGATION AND ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    许美; 林荣军; 刘莹莹; 路玲

    2012-01-01

    目的 了解青岛市儿童支气管哮喘合并变应性鼻炎的情况及二者关系.方法 随机抽取2010年5月-2011年10月在我院儿科门诊确诊的年龄≤14岁哮喘病儿372例,其中单纯哮喘232例(Ⅰ组),哮喘合并变应性鼻炎140例(Ⅱ组),选取非呼吸道疾病儿童372例作为对照组(Ⅲ组).通过家长笔答问卷,调查病儿一般情况、伴发疾病、家族史、个人过敏史、治疗情况等.结果 Ⅰ、Ⅱ组有家族及个人药物过敏史者明显多于Ⅲ组(x2=47.11~149.73,P<0.05),Ⅱ组有皮肤过敏史者明显多于Ⅰ组(x2=8.50,P<0.05).哮喘合并变应性鼻炎病儿中有63例(45.0%)先发生变应性鼻炎,55例(39.3%)先发生支气管哮喘.72.1%的哮喘合并变应性鼻炎病儿接受了鼻炎治疗,以单用或联合使用抗组胺药物和使用鼻用糖皮质激素为主要治疗措施.结论 支气管哮喘和变应性鼻炎是同一种疾病在不同部位的表现,两者有一定关联性,积极联合防治,可以提高治疗效果.%Objective To investigate the condition of children suffering from bronchial asthma complicated with allergic rhinitis in Qingdao and the relationship between the two conditions. Methods A random sampling of 372 asthma patients, aged ≤14 years old, confirmed in out-patient department of our hospital, from May 2010 to October 2011 , were divided into simple asthma group (Group 1,232 cases) , bronchial asthma complicated with allergic rhinitis group (Group 2,140 cases) , and 372 children with non-respiratory tract diseases (Group 3) served as controls. A questionnaire was used to survey their parents on genera! condition, concomitant diseases history of allergy, and treatment. Results The history of allergy of individuals and family members were more recorded in groups 1 and 2 than in group 3 (x2=47. 11 — 149. 73,P<0. 05). In group 2, the history of skin allergy was more than that in group 1 (x2 — 8. 50 , P<0. 05). Of the patients with combined

  8. 预防性治疗季节性变应性鼻炎临床研究%Clinical study of prophylactic treatment of seasonal allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    罗超; 刘巧平; 刘建华; 闫占峰; 周蕾; 矫璐璐; 巩政; 耿燕

    2016-01-01

    目的:观察预防性治疗季节性变应性鼻炎(AR)的疗效。方法选择变应原为蒿属花粉的中-重度持续性 AR 患者60例,随机分为预防性治疗组(以下简称治疗组)及对照组各30例,治疗组在花粉季开始前2周口服中药进行预防性治疗,对照组不予干预。花粉季开始后,2组患者均口服中药治疗6周。随访观察并记录2组患者流涕、鼻痒、喷嚏、鼻塞、眼痒症状评分及鼻部体征,并定期采用鼻结膜炎相关生活质量问卷评价 AR 对生活质量的影响。结果在花粉季高峰时治疗组流涕、鼻痒、鼻塞症状评分及 RQLQ 评分均轻于对照组,差异具有统计学意义(P <0.01)。整个花粉季期间,治疗组眼痒症状轻于对照组,差异具有统计学意义(P <0.01);治疗组鼻部体征总体程度轻于对照组,差异具有统计学意义(P <0.05)。结论花粉季前2周预防性治疗秋季蒿属花粉过敏的 AR 患者,可有效缓解患者临床症状,提高生活质量。%Objective To investigate the effect of prophylactic treatment on seasonal allergic rhinitis (AR).Methods 60 patients with moderate-severe persistent allergic rhinitis based on mugwort allergen were randomly divided into two groups,with 30 cases each in prophylactic group and control group re-spectively.Patients in prophylactic group were treated with traditional Chinese medicine 2 weeks before pollen season,and control group was given no treatment.At the beginning of pollen season,two groups accepted traditional Chinese medicine for 6 weeks.The symptom score of nose and eye was recorded by using a visual analogue scale.The quality of life was evaluated by rhinoconjunctivitis quality of life ques-tionnaire (RQLQ)periodically.Results In the peak pollen season,the symptom scores of nasal con-gestion,nasal itching,eye itching and nasal signs were significantly lower in the prophylactic group than those in the

  9. [Secretory eosinophilia and obstructive rhinitis].

    Science.gov (United States)

    Rouvier, P; Mondain, M; Elkhoury, J

    1992-01-01

    Detecting eosinophilia in the nasal secretions of patients complaining of nasal obstruction makes it possible to identify a group of high risk patients. Hosty use of surgery in these patients carries a high risk of iatrogenic complications and little potential for improvement. The 2 most frequently used methods of obtaining cytologic specimens (swabbing versus washing) were compared in 37 patients with obstructive rhinitis (early stage polyposis and nonallergic rhinitis with eosinophilia syndrome, NARES). Swabbing gave reliable results. Eosinophilia was negligible in a group of 25 control subjects. The mean eosinophil count was 2.5% and only 1 patient had a positive cystogram. The 220 patients which nasal obstruction were classed in 5 groups according to the severity of clinical signs and symptoms. The mean eosinophil count and the percentage of patients with positive cystogram increased with increased severity of the clinical syndrome. 28 patients had uncomplicated obstructive rhinitis, 10 had NARES, 43 had allergic rhinitis, 52 had chronic obstructive rhinitis, and 87 had nasosinal polyposis. The respective mean eosinophil counts were 6.42%, 10.3%, 13.8% 16.8% and 31.4%. The percentage of patients with positive cytograms was respectively, 10.8%, 20%, 23.3%, 28.8% and 54%.

  10. Clinical comparative study on the influence of acupoint sticking therapy in dog days and in non-dog days to the quality of life of allergic rhinitis patients%三伏天与非三伏天穴位贴敷对变应性鼻炎患者生活质量影响的比较研究

    Institute of Scientific and Technical Information of China (English)

    陈静; 邓桂珠; 陈芳; 张少杰; 郭雅斐; 陈俊琦; 王升旭

    2012-01-01

    目的:观察并比较三伏天与非三伏天穴位贴敷对变应性鼻炎患者生活质量的改善情况.方法:将55例患者随机分为三伏灸组(28例)和穴位贴敷组(27例).两组均采用三伏天灸方(穴取大椎、风门、肺俞等),三伏灸组在2010年三伏天期间进行5次穴位贴敷.穴位贴敷组在三伏天前进行5次穴位贴敷.采用鼻结膜炎生活质量量表(RQLQ)评价患者治疗前、治疗后及半年后随访的评分情况.结果:治疗后两组患者RQLQ评分中行为问题、鼻症状因子和总分分值均降低(均P<0.01);三伏灸组患者随访时情感反应的分值较前降低(P<0.05),穴位贴敷组患者非鼻/眼症状、眼部症状、情感反应在治疗后和随访时的因子分值均较前下降(P<0.01,P<0.05).与穴位贴敷组比较,三伏灸组患者治疗后和随访时的非鼻/眼症状、眼部症状、情感反应和生活质量总分下降幅度大(P<0.01,P<0.05).结论:同一季节段三伏天与非三伏天穴位贴敷均能改善变应性鼻炎患者的症状,但三伏贴对患者生活质量的改善更优.%Objective To observe and compare the influence of acupoint sticking therapy in dog days and in non-dog days to the quality of life of allergic rhinitis patients. Methods Fifty-five cases were divided into group A (the acupoint sticking therapy in dog days group, 28 cases)and group B (the acupoint sticking therapy in non-dog day group, 27 cases)randomly. The acupoint sticking therapy description (Dazhui (GV 14) ,Fertgmen (BL 12) ,Feishu (BL 13) etc. Was used in both groups. Five times of acupoint sticking therapy were given to patients in group A during dog days in 2010, while,another 5 times of acupoint sticking therapy were given to patients in group B before the dog days. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was used to evaluate the effects before, after and half a year after treatment. Results The scores of behavior problems,nasal symptoms

  11. DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4(+) T-Cell Population Structure

    OpenAIRE

    Nestor, Colm E; Fredrik Barrenäs; Hui Wang; Antonio Lentini; Huan Zhang; Sören Bruhn; Rebecka Jörnsten; Langston, Michael A.; Gary Rogers; Mika Gustafsson; Mikael Benson

    2014-01-01

    Altered DNA methylation patterns in CD4(+) T-cells indicate the importance of epigenetic mechanisms in inflammatory diseases. However, the identification of these alterations is complicated by the heterogeneity of most inflammatory diseases. Seasonal allergic rhinitis (SAR) is an optimal disease model for the study of DNA methylation because of its well-defined phenotype and etiology. We generated genome-wide DNA methylation (N(patients) = 8, N(controls) = 8) and gene expression (N(patients) ...

  12. Sublingual Immunotherapy Induces Regulatory Function of IL-10-Expressing CD4+CD25+Foxp3+ T Cells of Cervical Lymph Nodes in Murine Allergic Rhinitis Model

    Directory of Open Access Journals (Sweden)

    Takaya Yamada

    2012-01-01

    Full Text Available Sublingual immunotherapy (SLIT has been considered to be a painless and efficacious therapeutic treatment of allergic rhinitis which is known as type I allergy of nasal mucosa. Nevertheless, its mechanisms need to be further investigated. In this study, we constructed an effective murine model of sublingual immunotherapy in allergic rhinitis, in which mice were sublingually administered with ovalbumin (OVA followed by intraperitoneal sensitization and nasal challenge of OVA. Sublingually treated mice showed significantly decreased specific IgE responses as well as suppressed Th2 immune responses. Sublingual administration of OVA did not alter the frequency of CD4+CD25+ regulatory T cells (Tregs, but led to upregulation of Foxp3- and IL-10-specific mRNAs in the Tregs of cervical lymph nodes (CLN, which strongly suppressed Th2 cytokine production from CD4+CD25− effector T cells in vitro. Furthermore, sublingual administration of plasmids encoding the lymphoid chemokines CCL19 and CCL21-Ser DNA together with OVA suppressed allergic responses. These results suggest that IL-10-expressing CD4+CD25+Foxp3+ Tregs in CLN are involved in the suppression of allergic responses and that CCL19/CCL21 may contribute to it in mice that received SLIT.

  13. 变应性鼻炎和哮喘患者血清IL-5、IL-15及IL-18的水平研究%Expression of IL-5 、IL-15 and IL-18 in sera of patients with allergic rhinitis and/or bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    刘颖慧; 蒋捍东

    2010-01-01

    目的 探讨IL-5、IL-15和IL-18在变应性鼻炎、支气管哮喘、变应性鼻炎合并哮喘疾病中的作用.方法 采用双抗体夹心ELISA测定法对33例支气管哮喘患者、35例变应性鼻炎患者、35例变应性鼻炎合并哮喘的患者及35例正常健康查体者血清中IL-5、IL-15和IL-18的水平进行检测.结果 支气管哮喘、变应性鼻炎、变应性鼻炎合并哮喘的患者血清中IL-5、IL-15和IL-18水平较正常对照组升高(P<0.01),IL-5、IL-15,IL-18水平在变应性鼻炎合并哮喘组均高于鼻炎组与和哮喘组;鼻炎组IL-5水平高于哮喘组(P=0.003),哮喘组IL-18水平高于鼻炎组(P=0.001).结论 IL-5、IL-15和IL-18参与了过敏性鼻炎和哮喘的发病过程;变应性鼻炎合并哮喘的炎症程度较高;哮喘和鼻炎因发病部位不同炎症反应也有不同.%Objective To explore the effect of IL-5, IL-15 and IL-18 in pathogenesis of patient with allergic rhinitis (AR) and bronchial asthma. Methods The serum samples were obtained from 33 patients with asthma,35 patients with AR, 35 patients with AR and BA, and 35 controls. The serum levels of IL-5,IL-15 and IL-18 were measured by ELISA. Results The levels of IL-5,IL-15 and IL-18 were greatly increased in all patient groups than the control group (P<0.01). The levels of IL-5 ,IL-15 and IL-18 were greatly increased in AR and BA group than the group of BA and the group of AR.The level of IL-5 in the group of AR was higher than that in the group of BA.(P=0.003). The level of IL-18 in the group of BA was higher than that in the group of AR( P=0.001 ). Conclusions IL-5 ,IL-15 and IL-18play a prominent role in the pathogenesis of AR and BA. Inflammations in the group of AR accompanying BA group are much higher. there is difference in inflammations between BA and AR.

  14. 心身并治变应性鼻炎_哮喘综合征临床研究%Clinical Research on Psychosomatic Treatment of Combined Allergic Rhinitis and Asthma Syndrome

    Institute of Scientific and Technical Information of China (English)

    席斌; 席冬青; 蒋西玲; 程延安

    2015-01-01

    Objective:To observe the clinical curative effect of psychosomatic treatment of combined allergic rhinitis and asthma syn_drome( CARAS ). Methods:Patients were selected through the Hamilton anxiety scale( HAMA ) and Hamilton depression scale ( HAMD),a total of 62 cases. They were randomly divided into the study group and the control group. The control group was given by o_ral Chinese medicine decoction,and budesonide aerosol nasal spray,and the study group was given psychological treatment on the basis of control group. 4 weeks as a course of treatment. Asthma control test( ACT)score,rhinitis symptoms score,HAMA score and HAMD score of the two groups before and after treatment were compared. Results:After treatment,ACT score,rhinitis symptoms score,HAMA score,HAMD score of the two groups were improved(P0. 05),the other three showed difference (P0.05),其他三项均有显著差异( P<0.05)。结论:心身并治CARAS临床疗效显著。

  15. Adverse Events During Immunotherapy Against Grass Pollen-Induced Allergic Rhinitis - Differences Between Subcutaneous and Sublingual Treatment.

    Science.gov (United States)

    Aasbjerg, Kristian; Dalhoff, Kim Peder; Backer, Vibeke

    2015-08-01

    Allergic rhinitis (AR) triggered by grass pollen is a common disease, affecting millions of people worldwide. Treatment consists of symptom-alleviating drugs, such as topical corticosteroids or antihistamines. Another option is potentially curative immunotherapy, currently available as sublingual and subcutaneous treatment. We investigated the potential differences in the prevalence and severity of adverse events related to subcutaneous and sublingual immunotherapy (SLIT) against grass pollen-induced AR. A thorough literature search was performed with PubMed and EMBASE. The findings were compared with the available summaries of product characteristics (SPC) and with commercial pharmacology databases (Micromedex). The majority of available safety data originate from registered products of standardized allergens. A surprisingly large percentage of drugs, especially those used in the United States, have no systematically collected safety data. No sufficiently powered randomized trials comparing sublingual and subcutaneous immunotherapy (SCIT) were available, but general safety assessments indicate that sublingual tablet treatment is safer than subcutaneous treatment. Not all commonly used immunotherapy drugs are officially registered, and not all have systematically collected safety data. This is especially true for older drugs used in the United States. In contrast, newer drugs that have undergone extensive clinical testing have better documentation, but unified collection of safety data is still lacking. Considering the evidence available, most drugs elicit similar side effects from the same organ systems, and symptoms from the sublingual drug classes are probably less severe. However, a head-to-head comparison of safety and efficacy is lacking.

  16. Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to allergic rhinitis in Chinese populations: a systematic review and meta-analysis.

    Science.gov (United States)

    Huang, Ruo-Fei; Dong, Pin; Zhang, Tian-Zhen; Ying, Xin-Jiang; Hu, Hua

    2016-02-01

    In view of the controversies surrounding the angiotensin-converting enzyme (ACE)-allergic rhinitis (AR) association, a systematic review and meta-analysis of the ACE genetic association studies of AR was performed in Chinese populations. PubMed, Springer Link, OvidSP, Chinese biomedical database, Chinese national knowledge infrastructure, Chinese VIP and Wanfang databases were searched for related studies. A total of 4 studies including 415 AR patients and 309 controls were involved in this meta-analysis. Overall, significant association was found between ACE I/D polymorphism and AR risk when all studies in Chinese populations pooled into the meta-analysis (allele, OR 1.50, 95 % CI 1.19-1.90; homozygous, OR 2.59, 95 % CI 1.52-4.41, recessive, OR 2.05, 95 % CI 1.27-3.32). In the subgroup analysis by ethnicity, ACE I/D polymorphism was associated with significant elevated risks of AR in Chinese Han under homozygous and recessive models (homozygous, OR 4.36, 95 % CI 1.76-10.82, recessive, OR 2.51, 95 % CI 1.18-5.34). In conclusion, this meta-analysis provides the evidence that ACE I/D polymorphism may contribute to the AR development in Chinese populations and studies with large sample size and wider spectrum of population are warranted to verify this finding.

  17. 三伏灸对变应性鼻炎患者生活质量影响的临床研究%Clinical Research on Influence of the Dog-day Moxibustion on Quality of Life in Allergic Rhinitis Patients

    Institute of Scientific and Technical Information of China (English)

    陈俊琦; 王宁宁; 张继苹; 陈伟明; 黄焕琳; 陈静

    2012-01-01

    目的 探讨三伏灸对变应性鼻炎患者生活质量影响的特点.方法 60例患者通过随机数字表分为2组,治疗组接受三伏灸治疗,对照组接受荞麦粉等组成的安慰剂治疗.采用生活质量量表(RQLQ)评定患者治疗前后和半年后随访生活质量的变化.所得数据采用SPSS 13.0软件进行统计分析.结果 (1)与同组治疗前分值比较,治疗组行为问题、鼻症状和生活质量总分在治疗后和随访时分值均降低,差异有统计学意义(P<0.05),情感反应在随访时分值降低,差异有统计学意义(P<0.05);对照组日常生活、行为问题和生活质量总分降低,差异有统计学意义(P<0.05).与同组治疗后分值比较,治疗组患者眼症状在随访后分值升高,差异有统计学意义(P<0.05).(2)与对照组比较,治疗组行为问题、鼻症状、情感反应和生活质量总体情况在治疗后和随访时改善更明显,差异有统计学意义(P<0.05).结论 三伏灸可明显改善患者的生活质量,具体体现在鼻症状、行为问题和情感问题经治疗后得到持久改善.%To observe the influencing characteristic of ring - day moxibustion on quality of life in patients with allergic rhinitis, with a contrast of placebo. Methods Sixty patients were divided into two groups according to the random number table. The patients in the trial group received the dog - day moxibustion while those in the control group received the placebo which consisted of buckwheat, etc. The rhinoconjunctivitis quality of life questionnaire ( RQLQ ) was used to evaluate the change of life quality before and after the treatment, and 6 months later in follow - up. All the data was analyzed by SPSS 13. 0. Results ( 1 ) Compared with the scores before the treatment in the same group, for the trial group the scores of behavior problem, nasal symptoms and life quality were all significantly decreased after the treatment and in the follow - up ( P<0.05 ), and the

  18. Incidentally detected Castleman disease in a patient with allergic rhinosinu sitis

    Directory of Open Access Journals (Sweden)

    Stojšić Jelena

    2008-01-01

    Full Text Available INTRODUCTION Castleman disease was for the first time described in 1956 as a mediastinal tumour mass. Etiology of this disease is still unknown. The disease can be solitary and multicentric or rarely of a mixed type. The former is often of hyaline vascular type, while the latter is of plasma cell type. CASE REPORT Castleman disease was diagnosed in a 26-year old male patient when a well defined shadow was incidentally detected in the middle lobe of the right lung. A year before, he was diagnosed with allergic rhinitis to Ambrosia. Two years after surgery the patient was feeling well, and was without any recurrence, however, allergic rhinitis still persisted. CONCLUSION Castleman disease can occur in any organ containing lymph tissues. Most frequently the disease is described as mediastinal, rarely as an intrapulmonary tumorous mass, and it is most frequently seen in younger persons. The solitary type of Castleman disease is surgical treatable with a prospect of good prognosis, while the multicentric and mixed types recur despite treatment with cortisone, irradiation and cytostatics. As the association between Castleman disease and allergic diseases has not been confirmed up-tonow, it could be concluded that this patient suffered from two separated diseases.

  19. 宁夏地区变应性鼻炎与慢性鼻-鼻窦炎鼻息肉相关性研究%The correlation study of allergic rhinitis and chronic rhinosinusitis with nasal polyps in Ningxia region

    Institute of Scientific and Technical Information of China (English)

    马瑞霞; 底玲玲; 侯丽; 赵迪; 闫小会

    2012-01-01

    To investigate the correlation of allergic rhinitis and chronic rhinosinusitis with nasal polyps in the Ningxia region. Method;One hundred and sixteen patients diagnosed with allergic rhinitis, chronic rhinosinusitis with nasal polyps, allergic rhinitis combined with chronic rhinosinusilis with nasal polyps in the department of Otorhinolaryngology Head and Neck Surgery,Ningxia Medical University Hospital from 2009 January to December was analysed in this study, followed by grouping the experimental group 1 : allergic rhinitis(AR) group(46 cases), the experimental group Ⅱ : chronic rhinosinusitis with nasal polyps group(46 cases) , the experimental group Ⅲ : allergic rhinitis combined with chronic rhinosinusitis with nasal polyps group(24 cases), and the normal control group (31 cases). The skin prick test was used and the serum specific IgE concentration of selected objects was measured by enzyme linked immunosorbent assay. Result:①The positive rate of specific IgE in the experimental group I was 83, 3% ,the concentrated for specific IgE mainly graded in 0 to 3 level, The total positive rate of specific IgE in the experimental group U and Dl were 75. 0% and 87. 5%, ②The specific IgE concentration in the experimental group I , Ⅱ , Ⅲ and control group were 10.33 ± 2. 12(kU/L),8. 43±2. 23(kU/L)>5. 28±2. 16(kU/L), 1, 03 ± 3, 96 (kU/L) , respectively. The data analyzed using ANOVA showed that the specific IgE concentration in the experimental group I ,Ⅱ ,Ⅲ compared with the control group was significantly different;Conclusion :①The specific IgE concentration in the Ningxia region of allergic rhinitis, chronic rhinosinusitis with nasal polyps were graded in 0 to 3 level, mainly graded in 1 level and lower than other regions The positive rates of the skin prick test about Wormwood, German cockroach, house dust mites and pollen Ⅳ allergen were relatively higher in Ningxia region, ② The specific IgE concentration was relatively higher in the

  20. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts : an allergic comorbidity cluster

    NARCIS (Netherlands)

    Garcia-Aymerich, J.; Benet, M.; Saeys, Y.; Pinart, M.; Basagana, X.; Smit, H. A.; Siroux, V.; Just, J.; Momas, I.; Ranciere, F.; Keil, T.; Hohmann, C.; Lau, S.; Wahn, U.; Heinrich, J.; Tischer, C. G.; Fantini, M. P.; Lenzi, J.; Porta, D.; Koppelman, G. H.; Postma, D. S.; Berdel, D.; Koletzko, S.; Kerkhof, M.; Gehring, U.; Wickman, M.; Melen, E.; Hallberg, J.; Bindslev-Jensen, C.; Eller, E.; Kull, I.; Carlsen, K. C. Lodrup; Carlsen, K. -H.; Lambrecht, B. N.; Kogevinas, M.; Sunyer, J.; Kauffmann, F.; Bousquet, J.; Anto, J. M.

    2015-01-01

    BackgroundAsthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques. MethodsWe included 17209 children at 4years

  1. Curative Effect Observation of Montelukast Sodium Joint Budesonide Nasal Spray in the Treatment of Allergic Rhinitis%孟鲁司特钠联合布地奈德鼻喷剂治疗变应性鼻炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    郑艳

    2015-01-01

    Objective To analysis the clinical curative effect of budesonide nasal spray joint meng LuSi sodium of treatment with allergic rhinitis. Methods Choose 80 patients with allergic rhinitis,(35) were randomly divided into control group and observation group (45), compared two groups of clinical curative effect. Results Observation group effective rate was 97.78%,the control group was 45.71%,the observation group is significantly higher than control group (P<0.05). Conclusion For allergic rhinitis take budesonide nasal spray joint meng LuSi sodium treatment,curative effect is obvious.%目的:分析布地奈德鼻喷剂联合孟鲁司特钠治疗变应性鼻炎临床疗效。方法选取80例变应性鼻炎患者,随机分为对照组(35)与观察组(45),对比两组临床疗效。结果观察组有效率为97.78%,对照组为45.71%,观察组明显高于对照组(P<0.05)。结论对变应性鼻炎采取布地奈德鼻喷剂联合孟鲁司特钠治疗,疗效明显。

  2. Role of skin prick test in allergic disorders: A prospective study in Kashmiri population in light of review

    Directory of Open Access Journals (Sweden)

    Roohi Rasool

    2013-01-01

    Full Text Available Background: Skin prick test (SPT is the most effective diagnostic test to detect IgE mediated type I allergic reactions like allergic rhinitis, atopic asthma, acute urticaria, food allergy etc. SPTs are done to know allergic sensitivity and applied for devising immunotherapy as the therapeutic modality. Materials and Methods: This prospective study was conducted in the department of Immunology and Molecular medicine at SKIMS. A total of 400 patients suffering from allergic rhinitis, asthma and urticaria were recruited in this study. SPT was performed with panel of allergens including house dust mite, pollens, fungi, dusts, cockroach, sheep wool and dog epithelia. Allergen immunotherapy was given to allergic rhinitis and asthmatic patients as therapeutic modality. Results: In our study, age of patients ranged from 6 to 65 years. Majority of patients were in the age group of 20-30 years (72% with Male to female ratio of 1:1.5. Of the 400 patients, 248 (62% had urticaria, 108 (27% patients had allergic rhinitis and 44 (11% patients had asthma. SPT reaction was positive in 38 (86.4% with allergic asthma, 74 (68.5% patients with allergic rhinitis and 4 (1.6% patient with urticaria, respectively. Allergen immunotherapy was effective in 58% patients with allergic rhinitis and 42% allergic asthma. Conclusion: Identifiable aeroallergen could be detected in 86.4% allergic asthma and 68.5% allergic rhinitis patients by SPT alone. Pollens were the most prevalent causative allergen. There was significant relief in the severity of symptoms, medication intake with the help of allergen immunotherapy.

  3. Correlation research on nasal administration of vitamin D3 and immunoglobulin E and immunoglobulin G4 in patients with allergic rhinitis%维生素D3鼻腔给药对变应性鼻炎患者血清免疫球蛋白E和免疫球蛋白G4相关性研究

    Institute of Scientific and Technical Information of China (English)

    龚为群; 冯云海; 阎萍; 原永明; 李水军; 周雪颖; 徐峰; 杨世权; 任霞斌

    2015-01-01

    Objective To discuss the correlation between nasal administration of vitamin D3 and immunoglobulin (Ig) G4 and IgE in patients with allergic rhinitis (AR),and study the effect of vitamin D3 on the immune mechanism of AR.Methods Thirty patients with AR whose skin prick test (SPT) were positive were selected as observation group,and 30 patients with simple nasal septum deviation whose SPT were negative were selected as control group.All the patients were treated with vitamin D3 300 000 U nasal administration,once a week and 4 times in total.Seven days after treatment,the serum concentrations of IgE and IgG4 were measured by light-scattering and radio-immunoassay method.The changes were compared between before and after treatment.Results The serum concentrations of IgE and IgG4 in observation group before treatment were (280.91 ± 43.47) and (0.57 ± 0.12) g/L,and after treatment were (204.64 ± 46.32) and (0.88 ± 0.12) g/L,and there were statistical differences (P < 0.05).The serum concentrations of IgE and IgG4 in control group before treatment were (45.47 ± 6.01) and (0.42 ± 0.07) g/L,and after treatment were (43.40 ± 5.74) and (0.50 ± 0.07) g/L,and there were statistical differences (P < 0.05).Conclusions Vitamin D3 could affect the concentration of IgE and IgG4 in patients with AR.Vitamin D3 may become a prevention and treatment method for the AR.%目的 探讨维生素D3鼻腔给药与变应性鼻炎患者血清免疫球蛋白(Ig)G4和IgE的相关性,研究维生素D3对变应性鼻炎免疫机制的影响.方法 选取皮肤点刺试验(SPT)阳性的变应性鼻炎患者30例为观察组,SPT阴性的单纯鼻中隔偏曲患者30例为对照组,经鼻腔滴入注射用维生素D3 30万U,每周1次共4次.治疗后7d,用散射放免法测定血清IgE、IgG4浓度.比较给药前后血清浓度变化.结果 观察组给药前血清IgE和IgG4浓度分别为(280.91±43.47)和(0.57±0.12)g/L,给药后分别为(204.64±46.32)和(0.88 ±0.12) g/L,给药前后

  4. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Directory of Open Access Journals (Sweden)

    David H. Mudarri

    2016-01-01

    Full Text Available Two foundational methods for estimating the total economic burden of disease are cost of illness (COI and willingness to pay (WTP. WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$ of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7 billion for allergic rhinitis, $1.9 (1.1–2.3 billion for acute bronchitis, $15.1 (9.4–20.6 billion for asthma morbidity, and $1.7 (0.4–4.5 billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality.

  5. 三联疗法治疗过敏性鼻炎疗效观察%Clinical observation on treating allergic rhinitis with the Sanlian therapy

    Institute of Scientific and Technical Information of China (English)

    张茂亮

    2013-01-01

    Allergic rhinitis is a common disease, sneezing, nasal itching, runny nose and nasal congestion are the four most common symptoms, usually caused by exposure to pollen, dust and cold air, often causing dizziness, headache, suffocation and other symptoms. Seriously affected daily life and work; and the disease easily relapse. The author used the Sanlian therapy to treat allergic rhinitis and achieved a more satisfactory outcome, reported as follows.%过敏性鼻炎是临床常见病之一,喷嚏、鼻痒、流涕和鼻塞是最常见的四大症状。多因接触花粉、尘土及冷空气等诱发,常引起头昏,头痛;憋气窒息等症状,严重影响日常生活和工作;且此病较易复发。笔者采用三联疗法治疗过敏性鼻炎,取得较满意疗效,报道如下。

  6. AB042. Allergy Working Group Update: the burden and management of rhinitis and rhinosinusitis in UK primary care

    Science.gov (United States)

    Fokkens, Wytske; Nibber, Anjan; Chisholm, Alison; Hellings, Peter; Skinner, Derek; Price, David

    2016-01-01

    Background Rhinitis and rhinosinusitis are diseases of the upper airways with a high prevalence and when they are chronic with a high quality of life burden on patients and costs for society. To date, data on the primary care burden of rhinitis and rhinosinusitis are limited as is knowledge of how primary care physicians currently manage these patients. This study aims to quantify the burden of CRS and characterize related management approaches in UK primary care. Methods Patients with diagnostic codes for rhinitis and rhinosinusitis were identified within the UK’s Optimum Patient Care Research Database (OPCRD), a respiratory enriched primary care database. Consultations over a 5-year period (latest for each patient) code for rhinitis and rhinosinusitis symptoms resulting in prescriptions for antibiotics, oral steroids and/or antihistamines were identified. Diagnostic codes were used to further categorize patients into acute/chronic rhinitis/rhinosinusitis and allergic/non allergic chronic rhinitis subgroups. Prescribed therapies were categorized as: antibiotics (all); steroids (oral, injectable, nasal) and antihistamines, nasal spray and eye drops and mapped across rhinitis/rhinosinusitis and allergic/non-allergic patient subgroups. Results A total of 685,429 patients were identified with rhinitis and rhinosinusitis diagnostic codes. Of these patients: 80,900 (5%) had a diagnostic code for acute rhinitis (common cold); 176,353 (26%) for acute rhinosinusitis; 65,610 (10%) for chronic rhinosinusitis; 306,030 (45%) for chronic allergic rhinitis; 4,747 (1%) for chronic non-allergic rhinitis and 51,790 (8%) undefined chronic rhinitis. A total of 1,664,068 consultations for rhinitis and rhinosinusitis symptoms were identified, of which 185,730 (27%) resulted in an antibiotic prescription, 5,597 (0.8%) in an oral steroid prescription and 1,898 (0.3%) in an antibiotic and oral steroid prescription. Drug prescribing varied markedly across diagnostic subgroups with

  7. 变应性鼻炎患者血清总IgE和特异性IgE分析%Survey on distribution of serum total IgE and specific IgE in patients with allergic rhinitis in Shenzhen district

    Institute of Scientific and Technical Information of China (English)

    杨利桃; 黄秋花; 贾小莉

    2014-01-01

    Objective Toexplorethedistributivecharacteristicsofinhaledallergensresponsibleforallergicrhinitisinpopulationof Shenzhendistrictandtoprovidethescientificbasisforitsprevention,etiologicaldiagnosisandtreatment.Methods TheMediwissAllergen ScreeningSystemhadbeenappliedfordetectionoftotalserumIgEandallergen-specificIgEin569patientswithallergicrhinitis.Results The positive rate for Dermatophagoides farinae was the highest(62. 6%),followed by cockroach,dog dander and house dust,and their positive rates were 14. 4%,14. 1% and 10. 0% respectively. There was no significant statistical difference between males and females( P >0. 05),but there was difference between age groups. The positive rate of children group with allergic rhinitis was 87. 8%,and it was much higher than that of adult group( P 0.05),但儿童组吸入性过敏原阳性率为87.8%,成人组吸入性过敏原阳性率为65.4%,两者差异显著( P <0.0001);血清总IgE阳性率为81.9%,吸入性过敏原特异性IgE阳性率为74.2%,总IgE阳性率明显高于特异性IgE阳性率,差异有统计学意义( P <0.0001)。结论户尘螨是诱发深圳特区变应性鼻炎的主要过敏原;儿童AR患者过敏原阳性率高于成人AR患者,可能与其免疫系统发育尚不完善有关;联合检测血清总IgE和过敏原特异性IgE可提高变应性鼻炎诊断的准确性。

  8. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology.

    Science.gov (United States)

    Dykewicz, M S; Fineman, S; Skoner, D P; Nicklas, R; Lee, R; Blessing-Moore, J; Li, J T; Bernstein, I L; Berger, W; Spector, S; Schuller, D

    1998-11-01

    This document contains complete guidelines for diagnosis and management of rhinitis developed by the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology, representing the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology and the Joint Council on Allergy, Asthma and Immunology. The guidelines are comprehensive and begin with statements on clinical characteristics and diagnosis of different forms of rhinitis (allergic, non-allergic, occupational rhinitis, hormonal rhinitis [pregnancy and hypothyroidism], drug-induced rhinitis, rhinitis from food ingestion), and other conditions that may be confused with rhinitis. Recommendations on patient evaluation discuss appropriate use of history, physical examination, and diagnostic testing, as well as unproven or inappropriate techniques that should not be used. Parameters on management include use of environmental control measures, pharmacologic therapy including recently introduced therapies and allergen immunotherapy. Because of the risks to patients and society from sedation and performance impairment caused by first generation antihistamines, second generation antihistamines that reduce or eliminate these side effects should usually be considered before first generation antihistamines for the treatment of allergic rhinitis. The document emphasizes the importance of rhinitis management for comorbid conditions (asthma, sinusitis, otitis media). Guidelines are also presented on special considerations in patients subsets (children, the elderly, pregnancy, athletes and patients with rhinitis medicamentosa); and when consultation with an allergist-immunologist should be considered.

  9. Role of mucosal immunity in pathogenesis of asthma and allergic rhinitis%黏膜免疫在支气管哮喘及变应性鼻炎发病中的作用

    Institute of Scientific and Technical Information of China (English)

    李风森; 徐丹; 杜丽娟

    2011-01-01

    rhinitis. Methods A total of 82 patients with acute asthma, including 44 with asthma alone and 38 with asthma complicated with rhinitis, were included in this study. Another 30 patients with allergic rhinitis alone and 30 healthy controls were also included. The saliva, sputum, and nasal secretions (all 2 ml) were collected to observe the secretory immunoglobulin-A(slgA) by enzyme-linked immunosorbent assay(ELISA). Flow cytometry was employed to observe CD4+ , CD8+ lymphocytes in blood samples (2 ml) obtained from the elbow vein. The levels of eosinophil cationic protein(ECP) and serum total immunoglobulin E(T-IgE) were assessed by fluorescent enzyme immunoassay. Results Sputum sIgA levels in the asthmatic group, combination group, and rhinitis group were significantly lower than that in the normal control group (P<0. 01) ; saliva sIgA levels in the asthmatic group and combination group had a decreasing tendency but had no significant difference compared with that in the normal control group. sIgA levels in the nasal secretions in the asthma group and combination group were significantly higher than those in the normal control group (P<0.05) and rhinitis group (P<0.01), and there was no significant difference between the rhinitis group and the control group. Blood CD4+ cells in the asthmatic group and combination group were decreased than that in the normal control group (P<0.05). Blood CD8+ cells were similar in all the groups. CD4+/CD8+ cells in the asthma group was significantly more than those in the normal control group and rhinitis group (P< 0. 05). Serum T-IgE-levels in the combination group and rhinitis group were significantly higher than that in the normal control group (P<0.01). Serum ECP was hardly detected in the normal control group; that in the asthma group was significantly higher than that in the rhinitis group (P<0. 05), and that in the combined group was not significantly different with those in the asthma group or the rhinitis group. ECP

  10. 'Help for Hay Fever', a goal-focused intervention for people with intermittent allergic rhinitis, delivered in Scottish community pharmacies: study protocol for a pilot cluster randomized controlled trial

    NARCIS (Netherlands)

    Porteous, T.; Wyke, S.; Smith, S.; Bond, C.; Francis, J.; Lee, A.J.; Lowrie, R.; Scotland, G.; Sheikh, A.; Thomas, M.; Smith, Lorraine

    2013-01-01

    BACKGROUND: Despite the availability of evidence-based guidelines for managing allergic rhinitis in primary care, management of the condition in the United Kingdom (UK) remains sub-optimal. Its high prevalence and negative effects on quality of life, school performance, productivity and co-morbid re

  11. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

    DEFF Research Database (Denmark)

    Bousquet, Jean; Schünemann, Holger J; Hellings, Peter W

    2016-01-01

    decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les...... Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials....

  12. Allergen-specific regulation of allergic rhinitis in mice by intranasal exposure to IgG1 monoclonal antibody Fab fragments against pathogenic allergen.

    Science.gov (United States)

    Matsuoka, Daiko; Mizutani, Nobuaki; Sae-Wong, Chutha; Yoshino, Shin

    2014-09-01

    Fab fragments (Fabs) have the ability to bind to specific antigens but lack the Fc portion for binding to receptors on immune and inflammatory cells that play a critical role in allergic diseases. In the present study, we investigated whether Fabs of an allergen-specific IgG1 monoclonal antibody (mAb) inhibited allergic rhinitis in mice. BALB/c mice sensitized by intraperitoneal injections of ovalbumin (OVA) plus alum on days 0 and 14 were intranasally challenged with OVA on days 28-30, and 35. Fabs prepared by the digestion of an anti-OVA IgG1 mAb (O1-10) with papain were also intranasally administered 15min before each OVA challenge. The results showed that treatment with O1-10 Fabs significantly suppressed the sneezing frequency, associated with decrease of OVA-specific IgE in the serum and infiltration by mast cells in the nasal mucosa seen following the fourth antigenic challenge; additionally, the level of mouse mast cell protease-1, a marker of mast cell activation, in serum was decreased. Furthermore, infiltration of eosinophils and goblet cell hyperplasia in the nasal mucosa at the fourth challenge were inhibited by treatment with O1-10 Fabs. In conclusion, these results suggest that intranasal exposure to Fabs of a pathogenic antigen-specific IgG1 mAb may be effective in regulating allergic rhinitis through allergen capture by Fabs in the nasal mucosa before the interaction of the intact antibody and allergen.

  13. Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis.

    Science.gov (United States)

    Yu, Zhi-Jian; Zeng, Lu; Luo, Xiang-Qian; Geng, Xiao-Rui; Xu, Rui; Chen, Kun; Yang, Gui; Luo, Xi; Liu, Zhi-Qiang; Liu, Zhi-Gang; Liu, Da-Bo; Yang, Ping-Chang; Li, Hua-Bin

    2017-04-03

    It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin D3 (VD3) can regulate multiple bioactivities in the body. This study tests a hypothesis that VD3 facilitates the effect of specific immunotherapy (SIT) on Th2 response. We observed that treatment with either SIT or VD3 alleviated AR symptoms as well as reduced serum levels of specific IgE and T helper (Th) 2 cytokines, suppressed miR-19a (one of the members of the miR-17-92 cluster) and increased IL-10 in peripheral B cells, which was further improved in those AR patients treated with both SIT and VD3. The expression of miR-19a and IL-10 was significantly negatively correlated with each other in peripheral B cells of AR patients. Metabolites of VD3 formed a complex with retinoid acid receptor to repress the expression of miR-19a in B cells. We conclude that administration with VD3 promotes the effect of SIT on suppression of AR via repressing the expression of miR-19a in peripheral B cells.

  14. Allergic Rhinitis Quiz

    Science.gov (United States)

    ... Education Center Fellows-in-Training Grants & Awards Program Directors Practice Resources ASTHMA IQ Consultation and Referral Guidelines Practice Financial Survey Practice Tools Running a Practice Statements and Practice Parameters About AAAAI Advocacy Allergist / Immunologists: ...

  15. Treatment of perennial rhinitis with 2% solution of sodium cromoglycate.

    Science.gov (United States)

    Lobaton, P; Seranno, V; Rubio, N; Gomez, D

    1975-08-01

    This trial has demonstrated that S.C.G. is significantly better than placebo and therefore that a 2% solution of S.C.G. is effective in the treatment of perennial rhinitis. It would appear that better results can be obtained in patients who have a demonstrable allergic aetiology with a nasal eosinophilia.

  16. Alcohol consumption and the risk of self-reported perennial and seasonal allergic rhinitis in young adult women in a population-based cohort study

    DEFF Research Database (Denmark)

    Bendtsen, P; Grønbæk, M; Kjær, S. K.;

    2008-01-01

    Background Alcohol consumption has been suggested to be associated with the development of allergic rhinitis (AR), but there is limited data on the topic. Objectives The objective of this study was to investigate the association between alcohol consumption and the risk of developing AR among young...... associated with the risk of developing seasonal (OR, 2.01; 95% CI, 1.65-2.45) and perennial AR (OR, 2.28; 95% CI, 1.70-2.74). Smoking was not associated with an increased risk of developing AR. Conclusion In this population of young adult women, alcohol consumption was associated with an increased risk...... women. Methods Five thousand eight hundred and seventy Danish women aged 20-29 years participated in a prospective cohort study, and were free of seasonal and perennial AR at baseline (1991-1993). Alcohol consumption was assessed by a food frequency questionnaire. The main outcome measures were self...

  17. Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma

    DEFF Research Database (Denmark)

    Maloney, J; Durham, S; Skoner, D

    2015-01-01

    ). CONCLUSIONS: In the AR/C subjects with reported well-controlled mild asthma included in these studies, grass SLIT-tablet did not increase TEAE frequency, severe local allergic swelling, or systemic allergic reactions versus subjects without asthma. There was no indication that treatment led to acute asthma...

  18. Clinical Analysis of Perennial Allergic Rhinitis Specific Immunotherapy%常年性变应性鼻炎特异性免疫治疗的临床分析

    Institute of Scientific and Technical Information of China (English)

    陈紫晖

    2015-01-01

    Objective To study the clinical efficacy of perennial allergic rhinitis specific immune therapy, hoping to provide reference for the clinical treatment of.Methods For 205 cases of 2011-01~2011-12 in our hospital with specific immune therapy for perennial allergic rhinitis patients were retrospectively analyzed, as the observation group, after three years of treatment, pay a return visit to the 205 patients in 2014;205 cases of perennial allergic rhinitis patients and then take the same period with traditional antihistamines drugs com-bined hormone therapy as the control group, the difference in the overall effect of the two groups, Immunology Examination of the two groups of patients before and after treatment, improvement of immunological function of observation period.Results The total efficiency of two groups of patients were more than 85%, shows obvious curative effect of therapy has two groups of patients, but the difference is not obvi-ous, is not statistically significant (P>0.05);second, immunological function tests showed.The observation group venous blood IL-2, IL4 and IL5 levels were significantly improved in the control group before and after treatment, but the detection of several functional level was greatly improved, with significant difference (P<0.05).Conclusion The specific immune therapy has a good clinical curative effect of perennial allergic rhinitis, and significant improvement for immune function, can be effective in the prevention and treatment of allergic rhinitis, so it is worth popularizing in clinic.%目的:对常年性变应性鼻炎特异性免疫治疗的临床疗效进行研究,希望可以为临床治疗提供借鉴。方法对2011-01~2011-12间在我院用特异性免疫治疗方法治疗常年性变应性鼻炎的205例患者进行回顾分析,并将其作为观察组,经过三年治疗后,在2014年对这205例患者进行回访;然后选取同时期用传统抗组胺类药物联合激素治疗的205例常年

  19. 过敏性鼻炎患儿过敏原特异性IgE检测与临床意义%Detection of Specific IgE in Serum of Children with Allergic Rhinitis and Its Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    王红; 楼金吐

    2012-01-01

    目的 了解过敏性鼻炎儿童主要过敏原分布情况及特点,以指导临床防治.方法 采用免疫印迹法体外定量检测患儿血清中特异性IgE抗体及20种常见过敏原.结果 938例过敏性鼻炎患儿中,100%至少对一种以上的过敏原呈阳性反应,其中487例患儿总IgE>400IU/Ml,230例患儿总IgE在200IU/ml~400IU/ml之间.在检测20种过敏原中以户尘螨和屋尘的阳性率最高(90.0%,80.8%).结论 过敏性鼻炎患儿至少有一种特异性IgE抗体显著增加,户尘螨、屋尘、动物皮屑、羊肉和牛奶是引起儿童过敏性鼻炎的主要过敏原.儿童在春秋温暖季节易发过敏性鼻炎.%Objective To investigate the main allergen distribution and characteristic in the children with allergic rhinitis, as to guide the clinical prevention and treatment. Methods 938 cases with allergic rhinitis used immune print detecting the special IgE antibody and twenty kinds of common allergen in serum. Results In 938 cases with allergic rhinitis there were a positive result for special allergen at least. Among them the total IgE of 487 cases were more than 400IU/ml, the total IgE of 230 cases were between 200 and 400 IU/ml. In 20 common allergen, the leading allergen was house dust and mite, the positive results were 90.0% and 80. 8%. Conclusion The children with allergic rhinitis were more than one kind positive of specific allergen. The main allergens for the children with allergic rhinitis were house dust, dust mite, pet skin scraps, mutton and milk etc. The Bpring and autumn season caused easily allergic rhinitis in children.

  20. Analysis of efficacy and safety of standardized dust mites allergen vaccine in treatment of allergic rhinitis%标准化尘螨变应原治疗变应性鼻炎的疗效及安全性分析

    Institute of Scientific and Technical Information of China (English)

    桂晓钟; 纪东; 程静; 赵军; 王林; 蒋传亚

    2012-01-01

    目的 观察分析标准化尘螨变应原皮下注射治疗常年性变应性鼻炎的疗效及安全性.方法 对175 例尘螨过敏的变应性鼻炎患者进行标准化尘螨变应原皮下注射治疗,比较接受免疫治疗前与剂量累加阶段、剂量维持阶段的鼻部症状评分、体征评分和不良反应情况,分析评价特异性免疫治疗的疗效及安全性.结果 175例尘螨过敏的变应性鼻炎患者的鼻部症状与治疗前相比有明显减轻,差异有统计学意义(P﹤0.05);剂量累加阶段和剂量维持阶段的总有效率分别为84.57%和95.43%,单一尘螨过敏较以尘螨过敏为主的多种过敏原病例疗效较好,单一尘螨过敏显效的占全部病例的78.38%;多种过敏原过敏显效的占全部病例的40.38%.本组病例均未出现严重不良反应.结论 对尘螨引起的常年性变应性鼻炎进行规范化标准化变应原特异性免疫皮下注射治疗,是一种有效、安全和持久的对因治疗方法,并可有效控制哮喘症状.%Objective To observe and analyse the therapeutic effects and the safety of standard subcutaneous immuno - theraphy on the patients with perennial allergic rhinitis. Methods One hundred and seventy - five patients with allergic rhinitis caused by house - dust mites were selected. Clinical efficacy was evaluated by symptom and sign score after two stages of specific immunotherapy and compared with pre - treatment scores. Results The main symptoms of allergic rhinitis were significantly alleviated in those treated with standardized dust mites compared with those untreated. The difference was statistically significant ( P < 0.05 ). The effective rates were 84. 57% after the first phases of the SIT and 95. 43% after the second phases. Clinical efficacy on the house - dust mite allergic rhinitis patients was better than multi - allergen rhinitis patients. No serious complications or bad reaction were found in the treatment process. The treatment efficacy

  1. 玉屏风颗粒治疗过敏性鼻炎的临床疗效观察%Clinical effects of Yu Pingfeng granule in the treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    罗懿明; 易伟民

    2015-01-01

    目的:观察玉屏风颗粒联合西药治疗过敏性鼻炎的临床疗效。方法:将64例过敏性鼻炎患者随机分为对照组和观察组,每组各32例,两组患者均以西药进行抗过敏治疗,观察组在此治疗基础上加用中药复方制剂玉屏风散颗粒进行治疗,并比较两组患者喷嚏、流涕、鼻塞、鼻痒等临床症状改善时间及治疗2个月后的复发率。结果:观察组患者喷嚏、流涕、鼻塞、鼻痒等临床症状改善时间显著短于对照组,且治疗2个月后的复发率显著低于对照组,差异显著,均具有统计学意义( P﹤0.05)。结论:玉屏风颗粒联合西药治疗过敏性鼻炎的临床疗效显著,值得临床上推广应用。%Objective To observe the clinical effect of Yu Pingfeng granule combined with western medicine in the treatment of allergic rhinitis. Method 64 cases of patients with allergic rhinitis were randomly divided into control group and observation group,32 cases in each group,the patients of two groups were treated with western medicine of anti allergy treatment,on the basis of this,the patients of the observa-tion group were treated with Yu Pingfeng granule,and the improvement time of the clinical symptoms such of sneezing,runny nose,nasal con-gestion,nasal itching of patients in the two groups were compared,the recurrence rate were compared after 2 months of treatment. Results In the observation group,sneezing,runny nose,nasal congestion,nasal itching and other symptoms improved time was significantly shorter than that in control group after 2 months of treatment,and the recurrence rate was significantly lower than the control group,the difference was sig-nificant,the differences were statistically significant(P﹤0. 05). Conclusion The curative effect of Yu Pingfeng granule combined with west-ern medicine in the treatment of allergic rhinitis is significant,which was of clinical application.

  2. The Effectiveness of Levocetirizine in Comparison with Loratadine in Treatment of Allergic Rhinitis —A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Ralph Mösges

    2011-01-01

    Conclusions: The results of this meta-analysis illustrate greater effectiveness for treatment with the active substance levocetirizine as monotherapy in reducing allergic symptoms when compared to treatment with loratadine.

  3. Social support for patients with allergic diseases.

    Science.gov (United States)

    Latalski, Maciej; Makara-Studzińska, Marta; Gajewska, Marzena; Rudnicka-Drozak, Ewa

    2002-01-01

    In recent years special attention has been paid to the issue of social support. So far there has been no special, applied, definition that would explicitly describe what social support is indeed. It results from the fact that the issue of social support has been of interest for numerous disciplines of science that have own fields of research and practical application. These are, among others, psychology, sociology, pedagogy, medicine. The objective of the study is an attempt to analyze the level of social support by people with allergic diseases. The research instrument was a self-structured inquiry sheet consisting of 25 questions and socio-demographic details. The strongest support for the patients was offered by the closest family (84%), followed by friends (51%), further members of the family (28.8%), acquaintances (26%) and institutions (14.4%).

  4. Treatment of combined allergic rhinitis and asthma syndrome by nasal inhalation of budesonide%经鼻吸入布地奈德治疗过敏性鼻炎-哮喘综合征

    Institute of Scientific and Technical Information of China (English)

    刘颖慧; 付蔷; 张迎俊; 李明华

    2008-01-01

    Objective In recent years WAO advocated combined allergic rhinitis and asthma syndrome (CARAS),a new diagnostic term. Meanwhile, both upper and lower respiratory tract need united diagnosis and treatment. So CARAS patients were treated through inhalation of glucocorticoid using spacer for nose and mouth, thus to evaluate the value of inhaled glucocorticoid through nose in treatment of CARAS.Methods Eighty-six CARAS patients treated by inhaling budesonide through nose-mouth spacer were randomly assigned to mouth-inhaled group and nose-inhaled group. The score for nosal symptoms, chest symptoms,lung function and airway responsiveness were observed before and after treatment. Results Both nose-inhaled group and mouth-inhaled group improved the chest symptoms and pulmonary ventilation function and reduce airway hyperreactivity, showing significant difference after treatment( P<0.01). There was no significant difference between two groups after treatment ( P>0.05). But the nose-inhaled group was superior to the mouth-inhaled group in nosal symptoms improvement( P<0.01). Conclusions Compared with the oral inhalation, nasal inhalation of budesonide could not only control allergic rhinitis, but also prevent asthma,which should be recommended to apply in the prevention and treatment of CARAS patients.%目的 最近世界变态反应组织(WAO)提出了过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndrome,CARAS)这一新的诊断术语.同时指出上、下呼吸道疾病需要进行联合诊断和联合治疗.采用了鼻-口两用雾化器(spacer),分别经口或经鼻吸入糖皮质激素治疗CARAS患者,以评价经鼻吸入糖皮质激素在防治CARAS的价值.方法 采用鼻-口两用雾化器(商品名:吸保)吸入布地奈德气雾剂治疗86例CARAS患者,随机将患者分为经口吸入组和经鼻吸入组,同时观察了两组治疗前后的鼻部症状记分、胸部症状记分、肺功能和气道反应性.结果 鼻吸组

  5. Increase in the prevalence of rhinitis among Danish children from 1986 to 2001

    DEFF Research Database (Denmark)

    Håkansson, K; Thomsen, SF; Ulrik, Charlotte Suppli;

    2007-01-01

    .001). The increase was most pronounced among subjects who suffered from non-allergic rhinitis (p history of asthma and parental atopic disease were...... strong predictors of non-allergic rhinitis, whereas a history of asthma, parental atopic disease, bronchial hyperresponsiveness, eczema, and age at examination were statistically significant predictors of allergic rhinitis. The prevalence of non-allergic rhinitis among Danish children has increased...

  6. 捏脊配合针刺在瑞士治疗过敏性鼻炎58例%Fifty-eight cases of allergic rhinitis treated with chiropractic and acupuncture in Switzerland

    Institute of Scientific and Technical Information of China (English)

    高军; 韩景献; ZHANG Yi

    2010-01-01

    @@ Allergic rhinitis (AR) pertains to anaphylaxis in biomedicine while to the domain of "Bigiu"(鼻鼽)in Chinese medicine with the main symptoms of rhinocnesmus, sneezing, thin nasal discharge and nasal obstruction.The disease is often persistent with high ratio of recurrent attacks.Specific medicine or methods for the radical treatment are still not available.However, great progress on treatment of AR with acupuncture has been made in recent 10 years.

  7. Efficacy of Fexofenadine in the Indian Population suffering from Alergic Rhinitis & Chronic Urticaria

    Directory of Open Access Journals (Sweden)

    Bikash Medhi

    2006-04-01

    Full Text Available The present study was designed to evaluate the efficacy of fexofenadine in the Indian population sufferingfrom allergic rhinitis and chronic urticaria. A total number of two hundred patients of either sex withsimilar demographic profile were included in the study according to inclusion and exclusion criteria.These patients were treated with fexofenadine 120mg once daily for allergic rhinitis and fexofenadine180mg for chronic urticaria for 7 days. The efficacy was evaluated on the basis of symptoms evaluationscale score and medication effectiveness scale score at baseline, on the 3rd day and on the 7th day ofcompletion of treatment. Results indicate that fexofenadine is highly effective in the Indian population(p<0.001 suffering from allergic rhinitis and chronic urticaria.

  8. Kidney bean: a major sensitizer among legumes in asthma and rhinitis patients from India.

    Directory of Open Access Journals (Sweden)

    Ramkrashan Kasera

    Full Text Available BACKGROUND: The prevalence of IgE mediated food allergies has increased over the last two decades. Food allergy has been reported to be fatal in highly sensitive individuals. Legumes are important food allergens but their prevalence may vary among different populations. The present study identifies sensitization to common legumes among Indian population, characterizes allergens of kidney bean and establishes its cross reactivity with other legumes. METHODOLOGY: Patients (n = 355 with history of legume allergy were skin prick tested (SPT with 10 legumes. Specific IgE (sIgE and total IgE were estimated in sera by enzyme-linked immunosorbent assay. Characterization of kidney bean allergens and their cross reactivity was investigated by immunobiochemical methods. Identification of major allergens of kidney bean was carried out by mass spectrometry. PRINCIPAL FINDINGS: Kidney bean exhibited sensitization in 78 (22.0% patients followed by chickpea 65 (18.0% and peanut 53 (15%. SPT positive patients depicted significantly elevated sIgE levels against different legumes (r = 0.85, p<0.0001. Sera from 30 kidney bean sensitive individuals exhibited basophil histamine release (16-54% which significantly correlated with their SPT (r = 0.83, p<0.0001 and sIgE (r = 0.99, p<0.0001. Kidney bean showed eight major allergens of 58, 50, 45, 42, 40, 37, 34 and 18 kDa on immunoblot and required 67.3±2.51 ng of homologous protein for 50% IgE inhibition. Inhibition assays revealed extensive cross reactivity among kidney bean, peanut, black gram and pigeon pea. nLC-MS/MS analysis identified four allergens of kidney bean showing significant matches with known proteins namely lectin (phytohemagglutinin, phaseolin, alpha-amylase inhibitor precursor and group 3 late embryogenesis abundant protein. CONCLUSION/SIGNIFICANCE: Among legumes, kidney bean followed by chick pea and peanut are the major allergic triggers in asthma and rhinitis patients in India

  9. Effect of steroid nasal spray on pediatric allergic rhinitis in children with adenoidal hypertrophy%鼻用类固醇治疗儿童变应性鼻炎伴腺样体肥大疗效分析

    Institute of Scientific and Technical Information of China (English)

    韦一; 王德乐; 王韶鉴; 曾莉

    2015-01-01

    Objective To evaluate the curative effect of steroid nasal spray on pediatric allergic rhinitis with adenoidal hypertrophy.Methods A total of 261 children with adenoids served as the control group,of them,190 children (72.7%)were with adenoid hypertrophy.A total of 162 children with allergic rhinitis and adenoids served as the ex-perimental group,of them,110 children(67.2%)were with adenoid hypertrophy.The two groups were both treated by Fluticasone propionate nasal spray (50 μg per nostril a day)for 3 months.Results Adenoidal hypertrophy incidence was 72.7% in the control group and 67.2% in the experimental group (χ2 =1.16,P >0.05).112 (58.9%)patients in the control group and 89 (80.9%)patients in the experimental group had the adenoidal volume decreased (χ2 =19.04,P <0.01).Conclusion After steroid nasal spray treatment,the adenoidal volume is much more decreased in the experimental group than in the experimental group.Steroid nasal spray is the first choice for children with allergic rhinitis and adenoidal hypertrophy.%目的:探讨儿童变应性鼻炎(AR)与腺样体肥大的关系,评价鼻用类固醇治疗儿童变应性鼻炎伴腺样体肥大的疗效。方法对照组为单纯腺样体生长儿童261例,其中腺样体肥大190例(72.7%)。观察组为变应性鼻炎伴腺样体生长儿童162例,其中腺样体肥大110例(67.2%)。两组均给予鼻用类固醇(丙酸氟替卡松喷剂)持续喷鼻3个月后于鼻内镜下复查。结果对照组并发腺样体肥大构成比为72.7%,观察组并发腺样体肥大构成比为67.2%,差异无统计学意义(χ2=1.16,P >0.05)。对照组采用鼻用类固醇治疗后有效腺样体体积减少112例(58.9%),观察组有效腺样体体积减小89例(80.9%)(χ2=19.04,P <0.01)。结论经鼻用类固醇治疗,变应性鼻炎伴腺样体肥大患儿腺样体体积减小程度较单纯腺样体肥大患儿明显。对

  10. [Work-related rhinitis - Is it always an occupational disease?

    Science.gov (United States)

    Salski, Witold; Wiszniewska, Marta; Salska, Agata; Tymoszuk, Diana; Walusiak-Skorupa, Jolanta

    2016-12-22

    Rhinitis is a chronic inflammatory disease of the upper respiratory tract, characterized by a high prevalence and a complex pathogenesis. Work-related rhinitis (WRR) can be divided into occupational rhinitis (OR) and work-exacerbated rhinitis (WER). It is not only considered as a disease entity but also in the context of medical certification as the allergic disease associated with occupational exposure. Epidemiology of work-related rhinitis has been found to vary depending on the occupation and specific exposure, on the other hand the prevalence data may be underestimated due to the lack of uniform diagnostic criteria. This paper reviews the issues comprising the pathogenesis, epidemiology, diagnosis and treatment of patients with work-related rhinitis. It also discusses the significance of the disease in occupational medicine, particularly in terms of preventive worker care, general principles of good practice in primary and secondary WRR prevention and the necessary directions of changes in medical certification in the cases of occupational rhinitis. Med Pr 2016;67(6):801-815.

  11. Prevalence of food and airborne allergens in allergic patients in Kerman

    Directory of Open Access Journals (Sweden)

    Hamed Fouladseresht

    2014-07-01

    Full Text Available Background: Detection of various environmental allergens is the major challenge in allergic diseases and the only treatment is avoiding these allergens. The aim of this study was to determine the prevalence of food and airborne allergens in allergic patients using Skin Prick Test (SPT. Methods: A cross-sectional study was done on clinically confirmed patients of atopic-dermatitis (n=54, allergenic-rhinitis (n=64 and chronic-urticaria (n=39 who referred to asthma and allergy clinic at Afzali-Pour hospital in Kerman during 2008-2010. Skin prick test was done using allergen extracts to determine the patients' sensitivity to food and airborne antigens. Results: Fifty-nine percent of patients responded to at least one allergen. Allergy to airborne and food allergens was 55.9 % and 21.7%, respectively. Chenopodiaceae (22.9% and egg white (10.2% were most prevalent airborne and food allergens. Allergy to cockroach, egg white, egg yolk and tomato was significantly higher in males than in females (P<0.05. Conclusion: The results indicated that allergy to food and airborne allergens is different depending on the nutrition and environmental conditions.

  12. Influence of corticosteroids on system of cortisol-growth hormone in children withAllergic rhinitis%糖皮质激素鼻喷雾剂对儿童肾上腺皮质功能的影响

    Institute of Scientific and Technical Information of China (English)

    张文; 韩想莉; 刘晖; 李世东; 高小娥; 丁瑜

    2012-01-01

    目的:探讨应用糖皮质激素对变应性鼻炎儿童皮质醇、生长激素(GH)及身高的影响.方法:变应性鼻炎患儿25例(观察组)给予布地奈德鼻喷雾剂治疗,每鼻孔1掀,2次/d,疗程4周.同时口服氯雷他定糖浆,用药剂量为0.11~0.24mg/kg,1次/d,用药4周.治疗前和治疗后6个月采静脉血5ml,采用放射免疫分析法(RIA)测定其血清皮质醇、生长激素(GH)水平,应用标准法测量并记录观察组及对照组身高.结果:观察组儿童用药前及用药6个月后其血清皮质醇和GH水平均无显著性差异.观察组身高治疗前、治疗后6个月时与对照组儿童身高比较无显著性差异.结论:糖皮质激素对变应性鼻炎儿童血清皮质醇和GH及身高的生长发育无明显影响.%Objective: To explore the changes of cortisol-growth hormone before and after corticosteroids in children with allergic rhinitis and to observe the variation of height between sick children and healthy children. Methods: Twenty-five children with allergic rhinitis were collected as observation group, and the patients were re-ceived budesonide one spray per nostril, two times per day for 4 weeks. Meanwhile these children took orally lorata dine syrup for 4 weeks. The serum blood were collected before treatment and after treatment 6 months; the contents of cortisol and growtn normone (GH) were measured by radio immunoassay(RIA). Tne heignt was measured and recorded by standard method. Results: The levels of serum cortisol and GH in children with allergic rhinitis had no significant differences before and after 6 months therapy. The height of children in observation group and control group which were healthy and had the same age and gender had no significant differences before therapy and after 6 months therapy. Conclusions:The serum consentbations of cortisol and GH in children suffered from allergis rhini tis have no obvious change before and after 6 months budesonide spray. The height changes

  13. Allergic rhinitis is a local disease: the role of local IgE production, basophils and mast cells

    NARCIS (Netherlands)

    A. Kleinjan (Alex)

    2002-01-01

    textabstractThe introduction to this thesis summarizes the literature which indicates that there is a discrepancy between sensitisation and allergic disease. Two aspects which might play a role in this discrepancy are the differences between production and funtion of local versus systemic lgE and th

  14. Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs

    Directory of Open Access Journals (Sweden)

    Takeshi Nabe

    2008-01-01

    Conclusions: Local nasal immunotherapy may be clinically useful for allergic nasal blockage associated with nasal hyperresponsiveness. The mechanisms responsible for this effectiveness might not be related to IgE production. Additionally, the effectiveness for nasal tissue was dissociated from that seen for the ocular tissue.

  15. PREMEDICATION PROTOCOLS IN DENTAL PRACTICE IN NON-ALLERGIC PATIENTS.

    OpenAIRE

    Angelina Kisselova; Adriana Krasteva; Assya Krasteva

    2011-01-01

    The aim is to present some of the most prescribed premedication schemes prior to an upcoming dental analgesia in non-allergic patients. These schemes we would like to be proved as “standard protocols” in dental practice.

  16. Cytokine serum profiles in allergic and non-allergic asthma. Increased production of IL-10 by non-allergic asthmatic patients.

    Science.gov (United States)

    Sánchez-Guerrero, I; Vegara, R P; Herrero, N; García-Alonso, A M; Luna, A; Alvarez, M R

    1997-01-01

    Studies were undertaken to determine whether differences in serum cytokine balances could be involved in the pathogenesis of allergic and in non-allergic asthma. At this propose, interferon-gamma, tumor necrosis factor-alpha, interleukin-2, interleukin-4, interleukin-6, and interleukin-10 were measured by enzimoimmunoassay. The analysis was performed on 24 allergic and 24 non-allergic asthmatic patients and 16 healthy subjects. IFN-gamma and TNF-alpha, included into the type 1 cytokines, appeared significantly increased in the allergic with respect to the non-allergic asthmatic patients (p = 0.01) and (p < 0.001) respectively, while IL-10, which belongs to the type 2 cytokines, was significantly increased in the non-allergic asthmatic (p < 0.001). The IL-6 analysis did not show any significant difference in either of the study group. The most interesting finding was the high serum IL-10 values detected in intrinsic asthmatic patients, which in turn, suggests that this cytokine could participate in the regulation of different immunological features that occurs in non-allergic asthma, and maybe it could indicate a higher stimulated state of cells in this type of asthma. The data presented in this report show a different cytokine profile in serum from allergic and non-allergic asthmatic patients and denote a stronger prevalence of type 2 cytokines in intrinsic asthma.

  17. Characteristics of aeroallergens of children with allergic rhinitis in Foshan%佛山地区儿童变应性鼻炎患者吸入性变应原特点分析

    Institute of Scientific and Technical Information of China (English)

    于青青; 王跃建; 唐隽; 刘悦胜; 刘美华; 马新苗

    2016-01-01

    Objective To investigate the distribution of aeroallergens in children with allergic rhinitis (AR) in Foshan city and to analyze the relevant factors.Methods 562 children with AR treated at our outpatient department from September,2012 to September,2015 underwent skin prick tests (SPT) with allergopharma skin prick kit,which included 11 kinds of standardized common aeroallergens.The positive rate of variety of allergens was calculated.Their gender,age,family history,and histories of asthma and eczema were analyzed.Results The total positive rate of aeroallergens was 82.56% (464/562).The positive rates of dermatophagoides pteronyssinus (80.64%),dermatophagoides farina (78.66%),and tropical mites (59.31%) were the top three and the positive rates of dog hair (15.36%),cat hair (12.63%),and Blattella germanica (12.32%) came next.Among the positive patients,16 cases (3.30%) were allergic to only one aeroallergen,39(8.02%) to two,and 431 (88.68%)to three or more than three.The positive rate of SPT was different in three different age groups and the highest one was that of the 10-14 years old group (90.18%),that of the 7-10 years old group (87.57%) came next,and that of the 3-7 years old group (79.73%) was the lowest,but with no statistical differences between each two groups (x2=2.452,P>0.05).There was statistical difference in the positive rate of SPT between the female group and the male group (x2=7.195,P<0.05).The positive rate correlated with family history and histories of eczema and asthma.Conclusions The main aeroallergens in children with allergic rhinitis in Foshan city tested by SPT are dermatophagoides pteronyssinus,dermatophagoides farina,and tropical mites.The positive rate of aeroallergens correlates with the sex and age of children.The positive rate of children with family history and the histories of asthma and eczema is much higher than that of the control group.Early skin prick test is helpful for the early diagnosis and

  18. Allergic rhinitis and difficult asthma%治疗支气管哮喘必须同时兼顾过敏性鼻炎

    Institute of Scientific and Technical Information of China (English)

    何权瀛

    2004-01-01

    @@ 2001年由世界各国专家制定了过敏性鼻炎及其对哮喘的影响(allergic rhinitis and its impact onasthma,ARIA)指南[1],并成为世界卫生组织(WHO)创议的一部分,其中建议临床医生(包括呼吸科、耳鼻咽喉及变态反应科医生)对于支气管哮喘和过敏性鼻炎进行联合治疗和管理.目前对于上述两种疾病之间的关系已取得共识,即所谓"一个气道,一种疾病".Van Cauwenberge教授等[2]认为,变态反应性疾病其实是一种全身性疾病,如过敏性鼻炎与渗出性中耳炎、鼻息肉、上呼吸道感染、哮喘彼此相互关联(图1),他们估计80%的哮喘患者有过敏性鼻炎症状,而大约30%的过敏性鼻炎患者合并哮喘.

  19. Progress in diagnosis and treatment of children combined allergic rhinitis and asthma syndrome%儿童过敏性鼻炎-哮喘综合征诊治进展

    Institute of Scientific and Technical Information of China (English)

    郭茹茹

    2014-01-01

    过敏性鼻炎和支气管哮喘是儿童常见的呼吸道过敏性疾病,发病率逐年上升.既往认为两者是完全独立的疾病,而近年的研究表明两者从病因学、发病机制、病理学变化以及治疗方面高度相似,故提出“过敏性鼻炎-哮喘综合征”这一新的概念,是指同时发生临床或亚临床的过敏性鼻炎和支气管哮喘症状,二者需整体看待,进行联合诊断和治疗,从而极大程度减少了误诊,并减少药物的重复使用,提高临床疗效.该文就儿童过敏性鼻炎-哮喘综合征诊治进展作一综述.%Allergic rhinitis and bronchial asthma are two common respiratory allergic diseases in children and the incidence of the two diseases is increasing.They are regarded as mutually separate diseases,but recent studies suggest that there is a strong link between the two diseases,which is represented at the etiology,mechanisms,pathologic and therapeutic levels.So combined allergic rhinitis and asthma syndrome (CARAS),a new terminology has formally introduced to illustrate concurrent symptoms of allergic rhinitis and bronchial asthma.The diagnosis and treatment of CARAS need to be considered collectively.Therefore the incidence of misdiagnosis and repeated use of drugs can be significantly reduced,then improving the clinical efficacy.This article reviews progress of the diagnosis and treatment of CARAS in children.

  20. 特异性免疫治疗对慢性鼻窦炎伴变应性鼻炎患者鼻内镜手术效果的影响%Effect of specific immunotherapy on outcomes after endoscopic sinus surgery for chronic rhinosinusitis with allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    陈金湘; 赵青; 周宁霞

    2011-01-01

    目的 探讨特异性免疫治疗对慢性鼻窦炎(CRS)伴变应性鼻炎患者功能性内镜鼻窦手术(FESS)效果的影响.方法 将确诊为CRS伴常年性变应性鼻炎的57例患者按照尘螨过敏与否分成两组,尘螨过敏者为治疗Ⅰ组,FESS术后采用皮下免疫治疗;非尘螨过敏者为治疗Ⅱ组,单纯行FESS.分别对两组患者术前、术后6个月、术后1年的症状及体征进行评分并对比,采用鼻腔鼻窦结局测试-20 (SNOT-20)量表及Lund-Kennedy鼻内镜评分法.结果 两组患者术后6个月和1年的SNOT-20及Lund-Kennedy评分较术前均有明显改善(P<0.01),治疗Ⅰ组患者的疗效优于治疗Ⅱ组且组间差异有统计学意义(P<0.05).结论 特异性免疫治疗可改善CRS伴变应性鼻炎患者的手术效果.%Objective To investigate the effect of specific immunotherapy on outcomes after functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis (CRS) with allergic rhinitis. Method Fifty-seven CRS patients accompanied with perennial allergic rhinitis were divided into two groups according to the results of allergen skin prick test. Those who were allergic to dust mites, the treatment group I, were treated with subcutaneous immunotherapy after FESS, others were treatment group II and treated with FESS merely. Before and 6, 12 months after FESS, the nasal symptoms and signs of all patients were evaluated by sino-nasal outcome test-20 (SNOT-20) and Lund-Kennedy endoscopic scores, and compared with each other. Results Compared to the scores before FESS, the SNOT-20 and Lund-Kennedy scores of two groups are significantly improved in 6 months and one year after FESS (P<0.01). Significantly better curative effects were obtained in the treatment group I when compared with the treatment group Ⅱ (F<0.05). Conclusion Specific immunotherapy may improve the surgical outcomes in CRS patients with allergic rhinitis.

  1. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis

    Directory of Open Access Journals (Sweden)

    Maria Lauriello

    2012-01-01

    Full Text Available Background. Toll-like receptors (TLRs represent a family of evolutionarily conserved proteins, that represent a fundamental link between innate and adaptive immune responses. Aim. The purpose of this study was to investigate the expression of TLR4 and TLR9 in the normal nasal mucosa and in the mucosa of subjects with different phenotypes of rhinitis. Methodology. A confocal analysis of TLR4 and TLR9 (coexpression was carried out on biopsies from the inferior turbinate obtained from 4 patients affected by persistent allergic rhinitis, 8 patients with chronic rhino-sinusitis, and 6 patients with vasomotor rhinitis The results were compared with those of specimens obtained from 4 subjects undergoing nasal surgery, but with signs of nasal inflammation. Results. TLR4 and TLR9 were expressed in the healthy nasal mucosa; TLR4 and TLR9 expression was significantly decreased in allergic rhinitis. TLR4 was over expressed in the epithelium of chronic rhino-sinusitis. Both TLRs were co-expressed in the sub-epithelial infiltrate of chronic and vasomotor rhinitis, even though this expression was higher in the former compared with the latter. Conclusions. This study indicates that TLR4 and TLR9 show a different pattern of expression in different phenotypes of rhinitis, possibly related to the type and severity of the disease.

  2. Study of clinical immunotherapy in children with allergic asthma and rhinitis%过敏性哮喘和鼻炎患儿的临床免疫治疗研究

    Institute of Scientific and Technical Information of China (English)

    杭杲; 刘春霞

    2014-01-01

    目的:探讨过敏性哮喘和鼻炎患儿的特异性免疫治疗的临床应用。方法采用体外特异性过敏原检测系统对儿童医院门诊患儿进行血清过敏原特异性 lgE(SlgE)抗体和总 lgE 进行检测,对尘螨过敏患儿进行分组治疗,免疫治疗组采用粉尘螨滴剂舌下脱敏治疗,对照组按普通药物抗过敏治疗,治疗6个月、12个月给予临床控制指标评分,同时观察患儿血清中 SIgE 的改变。结果218例过敏患儿吸入性过敏114例(52.4%),食入性过敏101例(46.3%)。98例尘螨过敏患儿占总过敏者和吸入性过敏者的44.95%和85.96%。免疫治疗组与对照组比较差异有统计学意义(P <0.05);脱敏治疗患儿 SIgE 阳性率有所下降,但差异无统计学意义(P >0.05)。结论218例过敏患儿的特异性过敏原检测中尘螨过敏者最多;舌下特异性免疫治疗过敏性哮喘和鼻炎效果显著。%Objective To investigate the clinical application of specific allergen immunotherapy (AIT)for the children with al-lergic asthma and rhinitis.Methods The in vitro specific allergen test system was adopted to detect allergen specific IgE and total IgE in children outpatients of the Children's Hospital.The children patients with dust mite allergy were divided into groups for con-ducting therapy.The immunotherapy group adopted the Dermatophagoides farinae drops for hypoglossis desensitization therapy, while the control group was performed the anti-allergic therapy by the common drugs.The clinical control indicator scores were per-formed after 6-months and 12-month therapy and at the same time the change of serum specific LgE was observed.Results Among 218 cases of allergy,114 cases(52.4%)were inhalation allergy and 101 cases (46.3%)were food allergy.98 cases of dust mite al-lergy accounted for 44.95% of the total allergy and 85.96% of the inhalation allergy.The difference in the curative effects

  3. 三伏天穴位敷贴治疗过敏性鼻炎疗效观察%Observation on Therapeutic Effect of Acupoint Application for Treating Allergic Rhinitis on Dog Days

    Institute of Scientific and Technical Information of China (English)

    臧江红; 王丽华; 郭裕

    2012-01-01

    Objective:To observe the clinical efficacy of acupoint application for allergic rhinitis on Dog Days. Methods: Acupoint application was adopted on dog days. 65 cases with allergic rhinitis were treated by acupoint application at the selected point of Chu Fu, Zhongfu and Mofu with three times as a course of treatment,and then a follow-up was conducted in six months after the treatment. The therapeutic effect was analyzed and compared before and after the treatment. Results;The total effective rate was 81. 54% ;the main clinical symptoms and signs were improved significantly after the treatment and there was significant difference before and after the treatment(P <0.05). Conclusion;Acupoint Application on Dog Days has good therapeutic effect for the treatment of allergic rhinitis.%目的:观察三伏天穴位敷贴治疗过敏性鼻炎的临床疗效.方法:在三伏天采用选定腧穴敷贴的方法,治疗过敏性鼻炎患者65例,于初伏、中伏、末伏各敷贴1次,3次为1疗程,治疗结束0.5a后随访,分析比较治疗前后的疗效.结果:有效率为81.54%;治疗后主要临床症状、体征改善明显,治疗前后比较有显著性差异(P<0.05).结论:三伏天穴位敷贴治疗过敏性鼻炎具有较好的疗效.

  4. 上海地区变应性鼻炎患儿主要变应原的临床研究%Variability analysis of allergic rhinitis related allergens in children

    Institute of Scientific and Technical Information of China (English)

    朱华明; 张玉君; 张维天; 苏开明; 时海波

    2011-01-01

    目的 了解近年来上海地区变应性鼻炎患儿的变应原特征,为儿童变应性鼻炎的防治提供临床依据.方法 2005年6月~2010年5月间,对上海地区拟诊变应性鼻炎的儿童行皮肤点刺试验(SPT),分析检测结果,并探讨了阳性病例在性别、年龄、检测的年份及季节等方面的差异性.结果 646例患儿中SPT阳性率81.73%,变应原分布以屋尘螨、粉尘螨为主;阳性病例在性别及检测年、月份分布上的差异无统计学意义(P>0.05);年龄较小组(3~5岁组)的SPT阳性率较低(P<0.05).结论 尘螨为上海地区变应性鼻炎患儿的的主要变应原,致敏阳性率常年维持较高水平,提示了加强尘螨的长期管理在防治儿童变应性鼻炎方面的重要意义.%Objective To determine the features of allergens in children with allergic rhinitis during the recent 5 years of Shanghai, and provide clinical reference for local management strategies. Methods Children with primary diagnosis of allergic rhinitis in shanghai area were given skin prick test (SPT) from June, 2005 to May, 2010. The positive rates were calculated and further analysed in regarding to age, gender, testing months. Results Among 646 children, the total positive rate of SPT was 81.73%. Dermatophagoides farinae (Der. F) and Dermatophagoides pteronyssinus (Der. P) were identified as the mostly responsible allergens. Among the positive subjects, the younger group showed a lower SPT positive rate than the elder (P0.05), but no significant difference was found between the gender, years, or testing months (all, P>0.05). Conclusion Dust mite was the most common allergen in children with allergic rhinitis in Shanghai area, and its sensitization rate sustained constantly a high level around the year, suggesting the importance of long-term mite control during the management of children with allergic rhinitis in Shanghai area.

  5. Allergic rhinitis and its impact on asthma control and pulmonary function%变应性鼻炎对哮喘患者临床控制及肺通气功能的影响

    Institute of Scientific and Technical Information of China (English)

    张丽; 胡红; 陈雷; 曹璐; 刘巧维; 牛晓婷

    2012-01-01

    Objective To determine the impact of allergic rhinitis on asthma clinical control and lung function. Methods Sixty-three patients with asthma alone or patients with asthma combined with allergic rhinitis ( 36 males and 27 females, mean age: 48.6 ±16. 1 years ) were divided into asthma group( n =32) and asthma combined with allergic rhinitis ( AR ) group( n =31 ) at Chinese PLA general hospital. The Asthma Control Test ( ACT ) score, the Asthma Control Questionnaire ( ACQ ) score, rescue use of salbutamol agonist and percent predicted FEV, ( FEV, % ), percent predicted PEF ( PEF% ) were evaluated respectively between asthma alone group and asthma combined with AR group. Results The patients in asthma combined with AR group had a significantly( P < 0.05 ) lower ACT score ( 16.3 ±5.6) than those with asthma alone ( 19. 0 ±4. 7 ); whereas the ACQ score ( 2. 1 ± 1. 3 ) in patients with asthma combined with AR was significantly higher than those ( 1.4 ± 1. 1 ) with asthma alone( P <0.05 ). The need for the salbutamol-agonist as a rescue medication 4 ( 0,12 ) in patients with asthma combined with AR was significantly( P <0.05 ) higher than those 0( 0,5 ) with asthma alone. The FEV,% ( 64.7 ±23. 1 )% in patients with asthma combined with AR was significantly( P < 0. 05 ) lower than those ( 77.7 ±21.7 )% with asthma alone, and the PEF% ( 65. 8 ±22. 0 )% in the patients with asthma combined with AR was significantly( P <0.05 ) lower than those (79.4 ±26. 3 )% with asthma alone. Conclusion The patients with asthma combined with AR experienced more poor clinical control and severe asthmatic symptoms, and more need for salbutamol agonist as a rescue medication, and decreased in pulmonary function.%目的 探讨变应性鼻炎对支气管哮喘(简称哮喘)患者临床控制及肺通气功能的影响.方法 收集2010年5月-2011年7月解放军总医院呼吸科及耳鼻咽喉头颈外科门诊就诊的63例哮喘和哮喘合并变应性鼻炎患者,将其分为2

  6. Research on prevalence and related factors in allergic rhinitis%变应性鼻炎患病率及相关因素调查

    Institute of Scientific and Technical Information of China (English)

    王泽海; 林文森; 李书彦; 赵绍成; 王丽; 杨仲刚; 陈杰; 张振富; 于金珍

    2011-01-01

    Objective To obtain the prevalence and related factors in allergic rhinitis (AR) and other allergic diseases in rural area in China through epidemiological investigation with large sample and multi-faceted survey data. Methods Face to face survey was conducted in different regions( rural areas of Cangzhou, Hebei, coastal fishing village of Bohai Bay, area of Wuling Mountain, Chengde, urban areas of Tianjin) from April 2007 to May 2009. In the same time, serum specific IgE(sIgE) was detected in the digits of every 0, 1or 5 in them. SPSS 13.0 software was used to analyze the data. Results Five thousand and ten cases were investigated. There were 823 cases with the symptoms or signs of AR ( 16. 4% ). Four hundred and two cases were found to have positive serum sIgE antibody in 1576 detected cases(25.5% ).One hundred and fourty-six cases with nasal allergic symptoms or signs were diagnosed as AR. The incidence of AR was 9. 3% ( 146/1576 ). The occurrence of allergic symptoms or signs had a significant statistical difference with factors such as age, occupation, atopic constitution ( x2 value were 7. 96, 9. 73, 16. 53,8.95 respectively, all P < 0. 05 ), and it was closely related to lower respiratory tract allergies ( β = 2. 544,P <0. 01 ). The most common allergens were dog and cat epithelium in rural areas and dust mites in city.Conclusions The incidence of AR is higher whether in urban or rural areas, it should be taken seriously as the impact on human health. The occurrence is closely related to physical characteristics and environmental factors.%目的 通过对变应性鼻炎(alkrgic rhinitis,AR)流行病学之大样本的调查,获得以农村为主的AR的患病率及相关患病因素.方法 2007年4月至2009年5月在河北省沧州市农村、渤海湾黄骅市沿海渔村、承德市雾灵山区、天津市区分别以行政乡、村和街道、居民小区等为单位,按行政乡、村和街道、居民小区名册通过随机多级抽样和整群

  7. 低温等离子射频治疗阻塞性睡眠呼吸暂停低通气综合征合并变应性鼻炎%Clinical Analysis of Low-Temperature Plasma Radio Frequency Treatment For Osahs Complicated With Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    黄红星; 杨立; 唐梓轩; 赵之栋

    2011-01-01

    Objective To observe the clinical effect of treatment by low-temperature plasma radio frequency on obstructive sleep apnea-hypopnea syndrome (OSAHS) complicated with allergic rhinitis. Methods A total of 42 patients with OSAHS complicated with allergic rhinitis between January 2010 and May 2010 were chosen. All of the patients were treated by low-temperature plasma radio frequency nerve block, concha nasalis inferior ablation and other operations such as nasal septal construction. The nerve terminals of sphenopalatine nerve and anterior ethmoid nerve were blocked by ablatioa Epworth sleepiness scale (ESS) and visual analogue scale (VAS) were used to estimate the curative effects. Results The results of ESS and VAS were consistent with gaussian distribution. There were statistical significant difference between the scores of pre-and post-operation (P<0. 05). Conclusion The low-temperature plasma radio frequency treatment for OSAHS complicated with allergic rhinitis is easy,safe and efficient.%目的 观察低温等离子射频治疗阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,USAHS)合并变应性鼻炎的疗效.方法 对2010年1-5月收治的42例OSANS合并变应性鼻炎患者,采用低温等离子射频双下鼻甲减容、鼻腔内蝶腭神经及筛前神经末梢阻滞,并配合鼻中隔成形等手术.使用Epworth嗜睡评分量表(epworth sleepiness scale,ESS)和视觉模拟评分法(visual analogue scale,VAS)对治疗前及治疗3个月后的总体感受评分.结果 ESS评分与VAS评分均符合正态分布,手术前、后ESS评分[(14.22±4.21)分,(6.78±4.12)分]与VAS评分[(8.34±2.72)分,(3.96±1.02)分」差异有统计学意义(P<0.05).结论 低温等离子射频治疗OSAHS合并变应性鼻炎疗效较好.

  8. 枸地氯雷他定治疗过敏性鼻炎疗效观察%Efficacy of Desloratadine Citrate Disodium in the Treatment of Allergic Rhinitis

    Institute of Scientific and Technical Information of China (English)

    俞静

    2015-01-01

    Objective:To observe the clinical effect and safety of desloratadine citrate disodium in the treatment of allergic rhinitis ( AR) . Methods:Totally 80 patients were randomly divided into the control group and the observation group with 40 ones in each. There was no difference in gender, age, duration of allergic rhinitis, classification of serological specificity IgE between the two groups (P>0. 05). The observation group was treated with desloratadine citrate disodium tablets 8. 8mg, po, qd. The control group was given loratadine 10mg, po, qd. The treatment course was 12 days. All the patients were not given corticosteroids and other antihistamines. The clinical symptoms and signs integral, curative effect and adverse drug reactions during the treatment were observed. Results: In the observation group, 23 cases were markedly effective, 13 cases were effective, 3 cases were ineffective, one case didn’ t finish the study, and the total effective rate was 92. 30%. In the control group, the above index was 10 cases, 18 cases, 10 cases, 2 cases and 73. 68%, respectively. There was statistically significant difference in the total effective rate between the two groups (P0.05),观察组予以枸地氯雷他定片8.8 mg,po,qd,连续服用12 d。对照组予以氯雷他定10 mg,po, qd,连续服用12 d。所有观察患者均不使用皮质类固醇及其他抗组胺药物。观察两组患者治疗前后症状及体征积分、临床疗效及药品不良反应。结果:观察组显效23例,有效13例,无效3例,脱失1例,总有效率92.30%;对照组显效10例,有效18例,无效10例,脱失2例,总有效率73.68%;两组总有效率比较,差异有统计学意义(P<0.05)。观察组治疗后各项症状体征积分与对照组相比有明显降低,差异有统计学意义(P<0.05)。观察组药品不良反应发生率明显少于对照组。结论:枸地氯雷他定片治疗AR临床疗效优于氯雷他定,安全性好。

  9. Asma e rinite alérgica como expressão de uma única doença: um paradigma em construção Asthma and allergic rhinitis as symptoms of the same disease: a paradigm under construction

    Directory of Open Access Journals (Sweden)

    Paulo Augusto Moreira Camargos

    2002-12-01

    êuticas integradas para estas afecções.Objective: to describe current ideas about the relation between upper and lower respiratory tract and to review the epidemiological, immunological, and pathological aspects that support the paradigm of united airways disease. Sources: literature review using the Medline, MD Consult, HighWire, Medscape and Lilacs databases. We used allergic rhinitis and asthma as keywords, and searched articles published in the past 20 years. Summary of the findings: epidemiological evidence includes prevalence of allergic rhinitis in asthmatic patients and vice-versa, results of cross-sectional studies, bronchial hyperresponsiveness in patients with allergic rhinitis, importance of genetic and environmental factors, and the age of onset of atopic disease. Morphological and physiological aspects show structural differences between the nasal and bronchial mucosa, and the mechanisms that could explain the effect of rhinitis on asthma. Immunological aspects including the participation of bone marrow in the production of inflammatory cells and allergic reactions after allergen challenge are the same in allergic rhinitis and asthma. Finally, the results of the therapy for allergic rhinitis in bronchial hyperresponsiveness and in clinical and functional control of asthma are also reported. Conclusions: epidemiological evidence and immunological and pathological aspects suggest that there is a relation between allergic rhinitis and asthma. The paradigm of united airways disease suggests the implementation of an integrated therapeutic approach.

  10. 鼻舒适片联合枸地氯雷他定治疗过敏性鼻炎的临床研究%Clinical study on Bishushi Tablets combined with desloratadine citrate disodium in treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    陈阳静; 李宏慧; 赵瑞敏; 赵谦

    2016-01-01

    目的:探讨鼻舒适片联合枸地氯雷他定治疗过敏性鼻炎的临床疗效。方法选取2015年1月—2016年1月西安交通大学第一附属医院接受治疗的过敏性鼻炎患者138例,随机分为对照组和治疗组,每组各69例。对照组口服枸地氯雷他定胶囊,1粒/次,1次/d。治疗组在对照组的治疗基础上口服鼻舒适片,5片/次,3次/d。两组均连续治疗12 d。观察两组的临床疗效,同时比较两组治疗前后症状积分、白三烯 B4(LTB4)、IL-4、IL-10、IL-12、转化生长因子α(TGF-α)、γ-干扰素(IFN-γ)、IgE 的变化情况。结果治疗后,对照组和治疗组的总有效率分别为85.51%、95.65%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者症状(包括鼻塞、鼻痒、喷嚏、流涕)评分、总分、IL-4、IL-10、TGF-α、LTB4、IgE 水平均显著降低,IL-12、IFN-γ水平显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论鼻舒适片联合枸地氯雷他定治疗过敏性鼻炎具有较好的临床疗效,可改善患者的临床症状,改善各检测因子水平,具有一定的临床推广应用价值。%Objective To explore the clinical efficacy of Bishushi Tablets combined with desloratadine citrate disodium in treatment of allergic rhinitis. Methods Patients (138 cases) with allergic rhinitis in the First Affiliated Hospital of Xi’an Jiaotong University from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 69 cases. The patients in the control group were po administered with Desloratadine Citrate Disodium Capsules, 1 grain/time, once daily. The patients in the treatment group were po administered with Bishushi Tablets on the basis of the control group, 5 tablets/time, three times daily. The

  11. PREMEDICATION PROTOCOLS IN DENTAL PRACTICE IN NON-ALLERGIC PATIENTS.

    Directory of Open Access Journals (Sweden)

    Angelina Kisselova

    2011-08-01

    Full Text Available The aim is to present some of the most prescribed premedication schemes prior to an upcoming dental analgesia in non-allergic patients. These schemes we would like to be proved as “standard protocols” in dental practice.

  12. Immunological Characterization of Dutch Sesame Seed-Allergic Patients

    NARCIS (Netherlands)

    Teodorowicz, Malgorzata; Terlouw, Rozine J.; Jansen, Ad; Savelkoul, Huub F.J.; Ruinemans-Koerts, Janneke

    2016-01-01

    Background: Sesame seed is an allergen of growing importance worldwide. However, knowledge of the clinically relevant sesame allergen and its cross-reactivity with homologous allergens is limited. The aim of this study was the immunological characterization of Dutch sesame seed-allergic patients

  13. Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma

    DEFF Research Database (Denmark)

    Pedersen, W; Hjuler, Inga Merete; Bisgaard, H;

    1998-01-01

    compliance with the treatment. In the present study, we evaluated a nasal inhalation system used for the simultaneous treatment of rhinitis and asthma. In principle, it results in an airway deposition of the corticosteroid similar to that of inhaled allergens. Twenty-four children with perennial rhinitis...... and effective treatment for both rhinitis and asthma in children, but it is an open question whether the nasal inhalation system can improve the ratio of antirhinitis/antiasthma effects to side-effects.......The standard treatment of allergic rhinitis and asthma consists of topical corticosteroids administered intranasally and inhaled through the mouth. Although this therapy is highly effective, and side-effects are few and mild, it may be possible further to improve the therapeutic index and patient...

  14. 中西医学方法对变应性鼻炎疗效比较%The Comparison of Curative Effection on Allergic Rhinitis between Traditional Chinese Medicine and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    汪晓凯; 李彩霞; 李竹梅; 张秋红

    2011-01-01

    This text compares the curative effection on Allergic Rhinitis between Traditional Chinese Medicine (TCM) and Western Medicine. The disadvantages of Western Medicine include : axiomatize the pathomechanism and therapeutic schedule,without paying attention to premorbid phase,without holism concept. The features of TCM include: holism concept,harmonization between soma and spirit, the dialectic conception. There are advantages and disadvantages both in TCM and Western Medicine. Combination of TCM and Western Medicine is the developmental direction of Allergic Rhinitis in the future.%本文分别从中医学和西医学体系对变应性鼻炎疗效进行分析比较.西医学主要不足:病理机制和治疗方案的公理化,缺乏关注病前状态,缺乏整体观.中医学主要特点:整体观念、形神合一、辩证理念.中西医学均存在优势和不足.中西医学结合是今后诊治变应性鼻炎的发展方向.

  15. 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

    Directory of Open Access Journals (Sweden)

    Anna Bonanno

    2014-01-01

    Full Text Available Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC, 11 allergic rhinitis (AR patients, and 35 allergic asthma with rhinitis (AAR patients. We found significant lower levels of 25(OH Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH Vit D. In AAR 25(OH Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH Vit D in AR and AAR. In conclusion, low levels of 25(OH Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity.

  16. 盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎40例%Azelastine Hydrochloride Nasal Spray Combined with Desloratadine for Treating Allergic Rhinitis in 40 Cases

    Institute of Scientific and Technical Information of China (English)

    王明婧

    2015-01-01

    Objective To investigate the clinical effect of azelastine hydrochloride nasal sPray combined with desloratadine in the treatment of allergic rhinitis. Methods 80 cases of allergic rhinitis Patients were divided into two grouPs according to the random number table method,the control grouP were treated with azelastine hydrochloride nasal sPray,the observation grouP were given azelastine hydrochloride nasal sPray combined with desloratadine. The clinical effect of the two grouPs were observed and comPared after treatment. Results After treatment,the total effiective rate of the observation grouP (97. 50%) was significantly higher than that of the control grouP (70. 00%),with significant difference ( P < 0. 05); the incidence rate of comPlication,such as bronchial asthma, sinusitis,nasal PolyPs,middle ear inflammation and allergic of conjunctival inflammation of the observation grouP (5. 00% ) was significantly lower than that of the control grouP(32. 50%),with significant difference( P < 0. 05);the recurrence rate of allergic rhinitis in the observation(0)was significantly lower than that of the control grouP(27. 50%),with significant difference( P < 0. 05). Conclusion Azelastine hydrochloride nasal sPray combined with desloratadine in the treatment of allergic rhinitis has raPid effect, high safety,can effectively alleviate the clinical symPtoms with good clinical effect.%目的:观察盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎的临床疗效。方法采用随机数字表法将医院收治的80例过敏性鼻炎患者分为两组,对照组给予盐酸氮卓斯汀鼻喷剂治疗,观察组则采用盐酸氮卓斯汀鼻喷剂联合地氯雷他定口服治疗。结果治疗后,观察组总有效率为97.50%,明显高于对照组的70.00%( P<0.05);观察组治疗期间支气管哮喘、鼻窦炎、鼻息肉、中耳炎及变应性结膜炎等并发症的发生率为5.00%,明显低于对照组的32.50%( P<0.05)

  17. A study of eosinophil count in nasal and blood smear in allergic respiratory diseases in a rural setup

    Directory of Open Access Journals (Sweden)

    Naveen Kumar

    2012-01-01

    Full Text Available Allergic respiratory disorders are fairly common visiting cases in pediatrics outpatient department (OPD. With an appropriate history and detailed examination, diagnosis may not be problematic. Routine investigation may not contribute much to the final diagnosis but may help in ruling out other possibilities. This study was done to evaluate sensitivity and specificity of blood or nasal eosinophilia in subjects suffering from allergic respiratory disorders and also to assess the feasibility of nasal cytogram which is a simple, economical and reliable investigation in allergic respiratory disorders. This is a prospective clinical correlation study of patients attending outpatient department. 100 subjects aged between 2-18 years of either sex were selected for the estimation of eosinophil count in nasal and peripheral smear in allergic respiratory disorders. All allergic respiratory cases based on eosinophillia. The nasal and blood eosinophilia were compared with each other and clinical findings of allergic rhinitis with or without asthma were studied. In this study peak age incidence was seen between 11-18 years and it was more common in males. Rhinorrhoea, pale mucosa and nasal obstruction were common findings in allergic rhinitis with bronchial asthma. Nasal eosinophilia was seen in 52.4% and 64.9% of cases of allergic rhinitis and allergic rhinitis with asthma respectively. Blood eosinophilia was seen in 54% and 56.8% of cases of allergic rhinitis with asthma respectively. Nasal cytogram which is a simple, economical and non- invasive procedure can be used as an alternative to invasive peripheral smear eosinophilia as both are equally efficacious in diagnosing allergic respiratory diseases.

  18. Effect of Desloratadine in Treatment of Allergic Rhinitis%地氯雷他定治疗过敏性鼻炎的疗效分析

    Institute of Scientific and Technical Information of China (English)

    崔佳菲

    2016-01-01

    Objective Desloratadine effect in treatment of al ergic rhinitis is to be studied. Methods Chose 73 patients of al ergic rhinitis who were treated in hospital from October 2014 to October 2015 and separated them into two groups at random,39 patients in study group were given desloratadine medication treatment,while another 34 patients in control group were given placebo medication treatment,and then compared treatment effects and medication safety between two groups. Results Patients’treatment efficacy in study group was 92.31%,while treatment efficacy in control group was 82.35%,thus,treatment efficacy was much higher in study group and such a differential had statistic value(P<0.05). Besides,side-effect incidence in study group was 2.6%and it was up to 11.8%in control group. Thus,side-effect incidence in control group was quite higher than that in study group (P<0.05). Conclusion Desloratadine medication is quite effective in treatment of al ergic rhinitis,it is conducive to relieving patients’symptoms quickly with low side-effect incidence but high medication safety.%目的:探究过敏性鼻炎患者采用地氯雷他定治疗的方法和效果。方法选取2014年10月~2015年10月收支的73例过敏性鼻炎患者进行治疗,随机分组,实验组39例患者采用地氯雷他定治疗,对照组34例患者给予安慰剂的之力啊,比较患者的疗效和安全性。结果实验组患者治疗有效率为92.31%,对照组治疗有效率为82.35%。实验组患者得到更加显著的治疗效果,差异有统计学意义(P<0.05)。且实验组不良反应发生率为2.6%,对照组不良反应发生率为11.8%,对照组患者的不良反应率高于对照组(P<0.05)。结论过敏性鼻炎患者采用地氯雷他定治疗,身体不适的症状在短时间内得到缓解,不良反应较小,安全性高。

  19. 孔嗣伯老中医清热化湿通窍法治疗变应性鼻炎经验%Experience of Notable TCM Doctor Kong Sibo in Treating Allergic Rhinitis by Removing Heat Dampness and Relieving Stuffy Nose

    Institute of Scientific and Technical Information of China (English)

    段颖; 支楠

    2014-01-01

    孔嗣伯老中医治疗变应性鼻炎经验丰富,疗效显著。孔老认为变应性鼻炎属中医鼻鼽范畴,湿热内蕴是鼻鼽发生的重要病因病机,称之湿热鼻鼽。清热化湿通窍是治疗湿热鼻鼽的总则,临床治疗应注意整体观念,多因素考虑,辨别湿热所在脏腑经络而遣方用药。%Dr.Kong Si bo,is a veteran practitioner of traditional Chinese medicine,who has rich experience in treating curative effect of allergic rhinitis.Dr.Kong believes that allergic rhinitis belongs to Bi Qiu category of traditional Chinese medicine,and the interior reten-tion of damp heat is the main important pathogenesis of allergic rhinitis.Clearing heat and dampness and relieving stuffy nose is the gen-eral principles of treating damp heat of allergic rhinitis.As for clinical treatment,attention shall be paid to the integrated conception,mul-tiple factors to identify the damp heat position of meridians and collaterals including the viscera system.

  20. Effect of treatment of allergic rhinitis and asthma syndrome by inhaling and nasal spray corticosteroids%口鼻吸入丙酸氟替卡松对过敏性鼻炎-哮喘综合症患者的影响

    Institute of Scientific and Technical Information of China (English)

    林士军; 王桂杰; 刘玉春; 徐继庆; 陈兰春; 李观强

    2011-01-01

    Objective To observe the clinical effect of treatment of allergic rhinitis and asthma syndrome(CARAS) by different ways of inhaling corticosteroids. Methods Totally 55 cases of patients suffered from allergic rhinitis and asthma syndrome were randomly divided into two groups. Nasal spray group: 27 cases were treated with fluticasones propionate nasal spray 100μg (2 puffs) a.m. and 150μg (3 puffs) p.m. into each nostril twice daily. Inhaling group: 28 cases were treated with fluticasones propionate inhaling 250μ g (2 puffs) twice daily for 12 weeks, respectively. The symptom scores of rhinitis, asthma, quality of life and pulmonary function were examined before and after treatment. Results The symptom scores of rhinitis , ACT and QOL after treatment in nasal spay groups and inhaling groups were significantly improved (P < 0. 05 ), the scores of rhinitis in nasal spay groups than that in inhaling groups were significantly decreased ( P < 0. 05 ), the scores of ACT, QOL and pulmonary function in inhaling groups than that in nasal spay groups were significantly increased (P < 0. 05). Conclusions The symptoms of rhinitis and asthma, quality of life on CARAS in two groups by two ways of inhaling fluticasones propionate are greatly improved, however, it is not best ways and is no satisfaction that nasal spay or inhaling fluticasones propionate single on CARAS.%目的 探讨口吸及鼻吸激素对过敏性鼻炎-哮喘综合症(CARAS)患者临床症状及生存质量的影响.方法 55例过敏性鼻炎-哮喘综合症患者被随机分为两组,鼻吸组27例,给予丙酸氟替卡松鼻喷雾剂,早上每个鼻孔各2次,晚上每个鼻孔各3次,鼻腔吸入,每喷50μg;口吸组28例,给予丙酸氟替卡松吸入气雾剂,早上吸入2次,晚上吸入2次,经口吸入,每吸125μg.两组每日给药剂量均为500μg,分别于治疗前及治疗12周后统计患者鼻炎症状积分,哮喘控制测试评分,哮喘生存质量评分及肺功能.结果 两组

  1. Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis

    Directory of Open Access Journals (Sweden)

    Andrea Eichel

    2014-01-01

    Full Text Available Objectives. The meta-analysis aims to investigate the efficacy of ectoine nasal spray and eye drops in the treatment of allergic rhinitis and rhinoconjunctivitis symptoms. Design and Methods. This meta-analysis is based on yet unpublished data of four studies. Both nasal and eye symptoms were documented in patient diary cards. All scales were transformed into a 4-point scale: 0 = no, 1 = mild, 2 = moderate, and 3 = severe symptoms. Each symptom was analysed individually in a meta-analysis of the area under the curve values as well as in a meta-analysis of pre- and posttreatment comparison. Results. After seven days of treatment with ectoine nasal spray both nasal and ocular symptoms decreased significantly. A strong reduction of symptom severity was shown for the parameters rhinorrhoea (31.76% reduction and nasal obstruction (29.94% reduction. Furthermore, the meta-analyses of individual symptoms to investigate the strength of effect after seven days of medication intake showed significant improvement for nasal obstruction, rhinorrhoea, nasal itching, sneezing, itching of eyes, and redness of eyes. The improvement of the symptom nasal obstruction was associated with a strong effect 0.53 (±0.26. Conclusions. The ectoine nasal spray and eye drops seem to be equally effective as guideline-recommended medication in the treatment of rhinoconjunctivitis symptoms.

  2. Meta-analysis of the efficacy of ectoine nasal spray in patients with allergic rhinoconjunctivitis.

    Science.gov (United States)

    Eichel, Andrea; Bilstein, Andreas; Werkhäuser, Nina; Mösges, Ralph

    2014-01-01

    Objectives. The meta-analysis aims to investigate the efficacy of ectoine nasal spray and eye drops in the treatment of allergic rhinitis and rhinoconjunctivitis symptoms. Design and Methods. This meta-analysis is based on yet unpublished data of four studies. Both nasal and eye symptoms were documented in patient diary cards. All scales were transformed into a 4-point scale: 0 = no, 1 = mild, 2 = moderate, and 3 = severe symptoms. Each symptom was analysed individually in a meta-analysis of the area under the curve values as well as in a meta-analysis of pre- and posttreatment comparison. Results. After seven days of treatment with ectoine nasal spray both nasal and ocular symptoms decreased significantly. A strong reduction of symptom severity was shown for the parameters rhinorrhoea (31.76% reduction) and nasal obstruction (29.94% reduction). Furthermore, the meta-analyses of individual symptoms to investigate the strength of effect after seven days of medication intake showed significant improvement for nasal obstruction, rhinorrhoea, nasal itching, sneezing, itching of eyes, and redness of eyes. The improvement of the symptom nasal obstruction was associated with a strong effect 0.53 (±0.26). Conclusions. The ectoine nasal spray and eye drops seem to be equally effective as guideline-recommended medication in the treatment of rhinoconjunctivitis symptoms.

  3. Effects of dust mite allergen-specific immunotherapy on prevention and cure in children with asthma and allergic rhinitis and the reasons of symptom exacerbation during specific immunotherapy.%粉尘螨特异性免疫治疗变应性哮喘合并鼻炎疗效评价及治疗期间病情反复原因分析

    Institute of Scientific and Technical Information of China (English)

    谭永强; 鲍一笑; 沈瑾; 叶桂云; 陈柳

    2012-01-01

    Objective To evaluate the effects of dust mite allergen-specific immunotherapy combined with standardized management on prevention and cure in children with asthma and allergic rhinitis and analyze the reasons of the asthma and allergic rhinitis symptom exacerbation during specific immunotherapy. Methods One hundred and two children with established diagnosis of allergic asthma and allergic rhinitis to dust mite were enrolled in this study from january 2006 to december 2010, of whom 78 children received the treatment with specific immunotherapy (SIT) combined with standardized management for 2 to 4 year (as the test group) and the other 24 served as the control group with inhaled corticosteroids according to Global Initiative for Asthma (GINA) and Allergic Rhinitis and its Impact on Asthma (ARIA) in the same time. At the beginning, 6 months, 1 year, 2 years of the treament and 1 year after the treament,the clinical symptom and acute episode, pulmonery function (Peak Expiratory Flow, PEF) and Chinese children asthma control test (Ch-CACT) of the asthmatic children, symptem scores and Visual Analogue Scale( VAS) of allergic rhinitis were analyzed, while respiratory tract infection of all the patients were recorded at the second year and after 1 year of the treatment. The reasons of the asthma and allergic rhinitis symptom exacerbation during dust mite allergen-specific immunotherapy were analyzed. The data were analyzed by SPSS15.0. Results Compared with control group, the frequency of acute episode, the frequency of respiratory tract infection in test group were significantly decreased at the 2 years of the treament and 1 year after the treament. The PEFof asthmasic children were obviously improved in the test group at the 2 years of the treament and 1 year after the treament and the Ch-CACT were more higher in the test group than the control group at 1 year after the treament. Compared with control group, the symptem scores and VAS of allergic rhinitis were

  4. 药物和聚焦超声治疗变应性鼻炎的随机对照研究%Comparison of therapeutic effects between focused ultrasound under nasal endoscope and conventional drug therapy in treatment of allergic rhinitis-a prospective randomized trial

    Institute of Scientific and Technical Information of China (English)

    温蓓; 何刚

    2012-01-01

    目的 探讨药物和聚焦超声治疗中-重度持续性变应性鼻炎(allergic rhinitis,AR)的临床疗效及安全性.方法 100例中-重度持续性AR根据随机分配方案(完全随机设计),按1:1比例随机分配到药物组和聚焦超声组,每组各50例.药物组予鼻用皮质类固醇布地奈德鼻喷剂,以及抗组胺药氯雷他定,治疗4周;聚焦超声组使用CZB型超声波鼻炎治疗仪进行治疗.治疗结束后随访6个月进行疗效和安全性评估.结果 药物组显效率24%,有效率36%,无效率40%,总有效率为60%;聚焦超声组显效率38%,有效率50%,无效率12%,总有效率为88%.两组总有效率差异有统计学意义(P<0.05).术后患者均未出现并发症.结论 鼻内镜下采用聚焦超声治疗中-重度持续性AR具有操作简单、创伤小等优点,安全性高,近期效果优于药物组.%Objective To investigate the therapeulic effect and safely of focused ultrasound in treatment of allergic rhinitis under nasal endoscope. Methods One hundred patients with allergic rhinilis were enrolled in the study. They were randomly divided into to the ultrasound therapy and conventional drug therapy groups,50 in each. The Budesonide Nasal Spray and toraladine were used in the conventional drug therapy group for four weeks. The CZB ultrasound therapeulic system was used in the ultrasound therapeulic group under nasal endoscope. The therapeutic efficiency was evaluated by clinical symptoms controlled counting-scores according to the 2004 Chinese Lanzhou principle of treatment and recommendation program for allergic rhinitis. Results All the patients were followed-up al least 6 months. In the conventional drug therapy group,the excellent effective rate,effective rate,ineffective rate,and the total effective rate were 24% ,36% ,40% and 60% ,respectively. However,in the CZB ultrasound therapeulic group there rates were 38% ,50% ,12% and 88% ,respeetively. The excellent effective rate and effective rate were

  5. Allergen Immunotherapy in an HIV+ Patient with Allergic Fungal Rhinosinusitis

    OpenAIRE

    2015-01-01

    Patients with HIV/AIDS can present with multiple types of fungal rhinosinusitis, fungal balls, granulomatous invasive fungal rhinosinusitis, acute or chronic invasive fungal rhinosinusitis, or allergic fungal rhinosinusitis (AFRS). Given the variable spectrum of immune status and susceptibility to severe infection from opportunistic pathogens it is extremely important that clinicians distinguish aggressive fungal invasive fungal disease from the much milder forms such as AFRS. Here we descr...

  6. 血清IgE与免疫球蛋白游离轻链在变应性鼻炎中的表达及意义%The expression and significance of serum IgE and immunoglobulin free light chain in allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    梁红英; 陈玉辉; 谭晓光

    2016-01-01

    目的:探讨血清 IgE 与免疫球蛋白游离轻链在变应性鼻炎中的表达及意义。方法分析2013年1月至2014年12月接受治疗的变应性鼻炎患者的临床资料,设为观察组。同时选取同时期行体检的健康人群作为对照组。观察比较两组对象血清中白介素(IL)-4、IL -9、IL -17、IgE、免疫球蛋白游离轻链、κFLC、λFLC 水平。分析观察组患者IgE 与 IL -4、IL -9、IL -17的相关性和 IgE 与λFLC、κFLC 水平的相关性。结果观察组患者血清中 IL -4、IL -9、IL -17与 IgE 水平显著高于对照组,差异具有统计学意义( P ﹤0.05);采用 Pearson 相关性检验分析观察组患者血清中 IgE与 IL -4、IL -17水平的相关性,观察组患者 IgE 与 IL -4( r =0.576,P ﹤0.001)及 IL -17( r =0.584,P ﹤0.001)呈现显著正相关;观察组患者血清中κFLC、λFLC 水平显著高于对照组,差异具有统计学意义( P ﹤0.05);观察组患者血清IgE 与λFLC( r =0.653,P ﹤0.001)、κFLC( r =0.625,P ﹤0.001)水平呈现显著正相关。结论变应性鼻炎患者 IgE与 IL -4及 IL -17呈现显著正相关,血清中 IgE 与免疫球蛋白游离轻链水平亦呈现正相关关系,血清中 IgE 和免疫球蛋白游离轻链含量水平对变应性鼻炎的诊断具有一定的临床价值。significant positive correlation with IgE in patients with allergic rhinitis,serum level of IgE also has positive correlation with levels of free light chain immunoglobulin,serum levels of IgE and free light chain immunoglobulin have certain clinical significance in the diagnosis of allergic rhinitis.%Objective To explore the expression and significance of serum IgE and immunoglobulin free light chain in allergic rhinitis. Methods The clinical data of patients with allergic rhinitis for treatment in this hospital during January 2013 to December 2014 were selected as observation group. At the same time

  7. 变应性鼻炎与昆明气传花粉及气象条件的关系%Relationship among allergic rhinitis, regional pollens and meteorological conditions in Kunming area

    Institute of Scientific and Technical Information of China (English)

    程晟; 阮标; 余咏梅; 浦吉存

    2015-01-01

    Objective To evaluate the species,quantity and diffusionof allergenic pollens as well as the relationship among allergic rhinitis (AR),pollen species and meteorological conditions in Kunming area.Methods The exposure film was used to investigate the species of airborne pollen,the total number of these pollens during December 2009 to November 2010 by means of gravitational sedimentation,at the same time,AR patients were registered.The species of allergic pollen in Kunming area during the same period,and the statistic analysis was made with the meteorological elements,using the correlation analysis methods of Excel for data analysis.Results From December 2009 to November 2010,a total of 60 exposure films of pollen species was found,including 26 147 pollens.The annual airborne pollen showed two scattering peak,respectively:February to April and September to October;the number of advantage pollen was 17 species.The number of year-round drifting pollen was 13 species while 2 species showed two peaks on spring and autumn.There was another 26 new species added to the results of 2009-2010,compared with1987-1989,while the original 12 species were not seen.The drifting peak was the same.The number of allergen intradermal tests (AIT) positive AR patients was positively correlated with 16 pollen species,respectively,oleaceae,alnus nepalensis,walnut,palm,pigweed,fennel,Amaranthaceae,artemisia,rosa,Albizia julibrissin Durazz,gramineae,castor,Fraxinus L,populus,Morus alba L,hemp humulus,(r value were 0.689 7,0.550 1,0.742 1,0.755 2,0.771 2,0.663 3,0.556 1,0.568 3,0.659 8,0.607 4,0.834 7,0.664 3,0.745 9,0.634 7,0.718 3,0.777 2,all P < 0.05).The population of AIT positive AR patients was positively correlated with average temperature,average wind speed and other meteorological factors (r values were 0.552 0,0.883 5,both P < 0.05),and was negatively correlated with average relative humidity (r =-0.714 7,P <0.05).Conclusions Kunming had a large number of airborne pollen species

  8. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

    NARCIS (Netherlands)

    J. Bousquet (Jean); P.W. Hellings (P.); I. Agache; A. Bedbrook (A.); C. Bachert (Claus); K.-C. Bergmann (Karl-Christian); Bewick, M.; C. Bindslev-Jensen; Bosnic-Anticevitch, S.; Bucca, C.; Caimmi, D.P.; P. Camargos; G. Canonica (Gwalter); T.B. Casale (Thomas); N.H. Chavannes (Nicolas); A.A. Cruz; De Carlo, G.; R. Dahl; P. Demoly; Devillier, P.; J. Fonseca; W.J. Fokkens (Wytske); Guldemond, N.A.; T. Haahtela; Illario, M.; P.M. Just; M. Keil (Mark); L. Klimek (Ludger); P. Kuna; D. Larenas-Linnemann (Désirée); M. Morais-Almeida; Mullol, J.; Murray, R.; R. Naclerio; R.E. O'hehir; N. Papadopoulos; R. Pawankar (Ruby); Potter, P.; D. Ryan (Dermot); Samolinski, B.; H.J. Schünemann (Holger); A. Sheikh (Aziz); F.E.R. Simons; Stellato, C.; A. Todo Bom; Tomazic, P.V.; A. Valiulis (Arunas); E. Valovirta (Erkka); Ventura, M.T.; M. Wickman (Magnus); Young, I.; A. Yorgancioglu; T. Zuberbier (Torsten); W. Aberer (W.); C.A. Akdis; C.A. Akdis; I. Annesi-Maesano; Ankri, J.; I.J. Ansotegui (I.); J.M. Antó (Josep M.); Arnavielhe, S.; Asarnoj, A.; Arshad, H.; Avolio, F.; I. Baiardini (Ilaria); Barbara, C.; Barbagallo, M.; E.D. Bateman (Eric); B. Beghe; E.H. Bel; K.S. Bennoor (K.); Benson, M.; Białoszewski, A.Z.; T. Bieber (Thomas); L. Bjermer (Leif); Blain, H.; F. Blasi (Francesco); A.L. Boner; M. Bonini (Matteo); S. Bonini (Sergio); Bosse, I.; J. Bouchard (Jacques); L.P. Boulet; Bourret, R.; J. Bousquet (Jean); F. Braido (Fulvio); A. Briggs (Andrew); C.E. Brightling (C.); J. Brozek; Buhl, R.; Bunu, C.; Burte, E.; A. Bush (Andrew); Caballero-Fonseca, F.; M. Calderon (Moises); Camuzat, T.; D. Cardona (Doris); Carreiro-Martins, P.; Carriazo, A.M.; K.H. Carlsen (Karin); W.W. Carr (Warner); Cepeda Sarabia, A.M.; Cesari, M.; L. Chatzi (Leda); Chiron, R.; Chivato, T.; Chkhartishvili, E.; A.G. Chuchalin; Chung, K.F.; G. Ciprandi (G.); De Sousa, J.C. (J. Correia); L. Cox (Linda); Crooks, G.; A. Custovic; S.E. Dahlen; U. Darsow (U.); Dedeu, T.; D. Deleanu (D.); J. Denburg; De Vries, G.; Didier, A.; Dinh-Xuan, A.T.; D. Dokic (D.); H. Douagui; Dray, G.; R. Dubakiene (R.); S.R. Durham (Stephen); G. Du Toit (George); Dykewicz, M.S.; Eklund, P.; Y. El-Gamal (Y.); Ellers, E.; R. Emuzyte; Farrell, J.; A. Fink-Wagner (A.); A. Fiocchi (Alessandro); M. Fletcher (M.); Forastiere, F.; M. Gaga (Mina); A. Gamkrelidze (Amiran); Gemicioǧlu, B.; J.E. Gereda (J.); Van Wick, R.G. (R. Gerth); S. González Diaz (S.); Grisle, I.; L. Grouse; Gutter, Z.; M.A. Guzmán (M.); B. Hellquist-Dahl (B.); J. Heinrich (Joachim); Horak, F.; J.O.B. Hourihane; Humbert, M.; Hyland, M.; Iaccarino, G.; Jares, E.J.; Jeandel, C.; S.L. Johnston; G.F. Joos (Guy); Jonquet, O.; Jung, K.S.; M. Jutel (M.); Kaidashev, I.; Khaitov, M.; O. Kalayci; A.F. Kalyoncu (A.); Kardas, P.; P.K. Keith; M. Kerkhof (Marjan); H.A.M. Kerstjens (Huib); N. Khaltaev; M. Kogevinas (Manolis); Kolek, V.; G.H. Koppelman (Gerard); M.L. Kowalski; Kuitunen, M.; C.A. Kull (Christian); V. Kvedariene (V.); B.N.M. Lambrecht (Bart); S. Lau (Susanne); Laune, D.; L.T. Le; A.P. Lieberman (Andrew); B. Lipworth; J. Li (J.); K.C. Lødrup Carlsen (K. C.); R. Louis (Renaud); Lupinek, C.; W. MacNee; Magar, Y.; Magnan, A.; B. Mahboub; Maier, D.; Majer, I.; Malva, J.; Manning, P.; De Manuel Keenoy, E.; G.D. Marshall; M.R. Masjedi (M.); Mathieu-Dupas, E.; Maurer, M.; S. Mavale-Manuel; E. Melén (Erik); Melo-Gomes, E.; E.O. Meltzer; Mercier, J.; J. Merk (Jeroen); Miculinic, N.; F. Mihaltan (F.); B. Milenkovic (Branislava); Millot-Keurinck, J.; Y. Mohammad; I. Momas (I.); R. Mösges; Muraro, A.; L. Namazova-Baranova (L.); R. Nadif (Rachel); Neffen, H.; Nekam, K.; A. Nieto (Antonio); B. Niggemann; Nogueira-Silva, L.; Nogues, M.; T.D. Nyembue (T.); K. Ohta; Y. Okamoto; Okubo, K.; Olive-Elias, M.; S. Ouedraogo; P. Paggiaro (Pierluigi); I. Pali-Schöll (I.); S. Palkonen; P. Panzner (P.); Papi, A.; Park, H.S.; G. Passalacqua (Giovanni); S.E. Pedersen (Soren E.); Pereira, A.M.; O. Pfaar (Oliver); Picard, R.; B. Pigearias (B.); I. Pin (Isabelle); Plavec, D.; Pohl, W.; T.A. Popov; Portejoie, F.; D.S. Postma (Dirkje); L.K. Poulsen; D. Price (David); K.F. Rabe (Klaus F.); Raciborski, F.; G. Roberts; Robalo-Cordeiro, C.; Rodenas, F.; L. Rodríguez-Mañas (Leocadio); Rolland, C.; M. Roman Rodriguez (M.); A. Romano; J. Rosado-Pinto; K. Rosario (Karyna); Rottem, M.; M. Sanchez-Borges; Sastre-Dominguez, J.; G.K. Scadding; Scichilone, N.; P. Schmid-Grendelmeier (Peter); Serrano, E.; M.D. Shields; V. Siroux (V.); J.C. Sisul (J.); Skrindo, I.; H.A. Smit (Henriëtte); D. Solé (D.); Sooronbaev, T.; O. Spranger; Stelmach, R.; P.J. Sterk (Peter); Strandberg, T.; J. Sunyer (Jordi); C. Thijs (Carel); M. Triggiani (M.); R. Valenta; A.L. Valero (A.); Van Eerd, M.; Van Ganse, E.; Van Hague, M.; O. Vandenplas (Olivier); Varona, L.L.; Vellas, B.; Vezzani, G.; Vazankari, T.; G. Viegi; Vontetsianos, T.; Wagenmann, M.; Walker, S.; D.Y. Wang (De Yun); U. Wahn (Ulrich); Werfel, T.; Whalley, B.; D. Williams; Williams, S.; Wilson, N.; J. Wright (Juliet); B.P. Yawn (Barbara); P.K. Yiallouros (P.); O.M. Yusuf (Osman); Zaidi, A.; H.J. Zar; M. Zernotti; Zhang, L.; Zhong, N.; M. Zidarn (M.)

    2016-01-01

    textabstractThe Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to de

  9. ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

    NARCIS (Netherlands)

    Bousquet, J; Hellings, P W; Agache, I; Bedbrook, A; Bachert, C; Bergmann, K C; Bewick, M; Bindslev-Jensen, C; Bosnic-Anticevitch, S; Bucca, C; Caimmi, D P; Camargos, P A M; Canonica, G W; Casale, T; Chavannes, N H; Cruz, A A; De Carlo, G; Dahl, R; Demoly, P; Devillier, P; Fonseca, J; Fokkens, W J; Guldemond, N A; Haahtela, T; Illario, M; Just, J; Keil, T; Klimek, L; Kuna, P; Larenas-Linnemann, D; Morais-Almeida, M; Mullol, J; Murray, R; Naclerio, R; O'Hehir, R E; Papadopoulos, N G; Pawankar, R; Potter, P; Samolinski, B; Schunemann, H J; Sheikh, A; Simons, F E R; Stellato, C; Todo-Bom, A; Tomazic, P V; Valiulis, A; Valovirta, E; Ventura, M T; Wickman, M; Young, I; Yorgancioglu, A; Zuberbier, T; Aberer, W; Akdis, C A; Akdis, M; Annesi-Maesano, I; Ankri, J; Ansotegui, I J; Anto, J M; Arnavielhe, S; Asarnoj, A; Arshad, H; Avolio, F; Baiardini, I; Barbara, C; Barbagallo, M; Bateman, E D; Beghé, B; Bel, E H; Bennoor, K S; Benson, M; Białoszewski, A Z; Bieber, T; Bjermer, L; Blain, H; Blasi, F; Boner, A L; Bonini, M; Bonini, S; Bosse, I; Bouchard, J; Boulet, L P; Bourret, R; Bousquet, P J; Braido, F; Briggs, A H; Brightling, C E; Brozek, J; Buhl, R; Bunu, C; Burte, E; Bush, A; Caballero-Fonseca, F; Calderon, M A; Camuzat, T; Cardona, V; Carreiro-Martins, P; Carriazo, A M; Carlsen, K H; Carr, W; Cepeda Sarabia, A M; Cesari, M; Chatzi, L; Chiron, R; Chivato, T; Chkhartishvili, E; Chuchalin, A G; Chung, K F; Ciprandi, G; de Sousa, J Correia; Crooks, G; Custovic, A; Dahlen, S E; Darsow, U; Dedeu, T; Deleanu, D; Denburg, J A; Didier, A; Dinh-Xuan, A T; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, S R; Du Toit, G; Dykewicz, M S; El-Gamal, Y; Ellers, E; Emuzyte, R; Farrell, J; Fink Wagner, A; Fiocchi, A; Fletcher, M; Forastiere, F; Gaga, M; Gamkrelidze, A; Gemicioğlu, B; Gereda, J E; van Wick, R Gerth; González Diaz, S; Grisle, I; Grouse, L; Gutter, Z; Guzmán, M A; Hellquist-Dahl, B; Horak, F; Hourihane, J O' B; Humbert, M; Hyland, M; Iaccarino, G; Jares, E J; Jeandel, C; Johnston, S L; Joos, G; Jonquet, O; Jung, K S; Jutel, M; Kaidashev, I; Khaitov, M; Kalayci, O; Kalyoncu, A F; Kardas, P; Keith, P K; Kerkhof, M; Kerstjens, H A M; Khaltaev, N; Kogevinas, M; Kolek, V; Koppelman, G H; Kowalski, M L; Kuitunen, M; Kull, I; Kvedariene, V; Lambrecht, B; Lau, S; Laune, D; Le, L T T; Lieberman, P; Lipworth, B; Lodrup Carlsen, K C; Louis, R; Lupinek, C; MacNee, W; Magar, Y; Magnan, A; Mahboub, B; Maier, D; Majer, I; Malva, J; Manning, P; De Manuel Keenoy, E; Marshall, G D; Masjedi, M R; Mathieu-Dupas, E; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, E O; Mercier, J; Miculinic, N; Mihaltan, F; Milenkovic, B; Millot-Keurinck, J; Mohammad, Y; Momas, I; Mösges, R; Muraro, A; Namazova-Baranova, L; Nadif, R; Neffen, H; Nekam, K; Nieto, A; Niggemann, B; Nogueira-Silva, L; Nogues, M; Nyembue, T D; Ohta, K; Okamoto, Y; Okubo, K; Olive-Elias, M; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Palkonen, S; Panzner, P; Papi, A; Park, H S; Passalacqua, G; Pedersen, S; Pereira, A M; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, T A; Portejoie, F; Poulsen, L K; Price, D; Rabe, K F; Raciborski, F; Robalo-Cordeiro, C; Rodenas, F; Rodriguez-Mañas, L; Rolland, C; Romano, A; Rosado-Pinto, J; Rosario, N; Rottem, M; Sanchez-Borges, M; Sastre-Dominguez, J; Scadding, G K; Scichilone, N; Schmid-Grendelmeier, P; Serrano, E; Shields, M; Siroux, V; Sisul, J C; Skrindo, I; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, P J; Strandb