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Sample records for algorithm antigen multiplier

  1. Synthesis algorithm of VLSI multipliers for ASIC

    Science.gov (United States)

    Chua, O. H.; Eldin, A. G.

    1993-01-01

    Multipliers are critical sub-blocks in ASIC design, especially for digital signal processing and communications applications. A flexible multiplier synthesis tool is developed which is capable of generating multiplier blocks for word size in the range of 4 to 256 bits. A comparison of existing multiplier algorithms is made in terms of speed, silicon area, and suitability for automated synthesis and verification of its VLSI implementation. The algorithm divides the range of supported word sizes into sub-ranges and provides each sub-range with a specific multiplier architecture for optimal speed and area. The algorithm of the synthesis tool and the multiplier architectures are presented. Circuit implementation and the automated synthesis methodology are discussed.

  2. An Efficient 16-Bit Multiplier based on Booth Algorithm

    Science.gov (United States)

    Khan, M. Zamin Ali; Saleem, Hussain; Afzal, Shiraz; Naseem, Jawed

    2012-11-01

    Multipliers are key components of many high performance systems such as microprocessors, digital signal processors, etc. Optimizing the speed and area of the multiplier is major design issue which is usually conflicting constraint so that improving speed results mostly in bigger areas. A VHDL designed architecture based on booth multiplication algorithm is proposed which not only optimize speed but also efficient on energy use.

  3. ON LU FACTORIZATION ALGORITHM WITH MULTIPLIERS

    African Journals Online (AJOL)

    Various algorithm such as Doolittle, Crouts and Cholesky's have been proposed to factor a square matrix into a product of L and U matrices, that is, to find L and U such that A = LU; where L and U are lower and upper triangular matrices respectively. These methods are derived by writing the general forms of L and U and the ...

  4. A Lagrange multiplier based divide and conquer finite element algorithm

    Science.gov (United States)

    Farhat, C.

    1991-01-01

    A novel domain decomposition method based on a hybrid variational principle is presented. Prior to any computation, a given finite element mesh is torn into a set of totally disconnected submeshes. First, an incomplete solution is computed in each subdomain. Next, the compatibility of the displacement field at the interface nodes is enforced via discrete, polynomial and/or piecewise polynomial Lagrange multipliers. In the static case, each floating subdomain induces a local singularity that is resolved very efficiently. The interface problem associated with this domain decomposition method is, in general, indefinite and of variable size. A dedicated conjugate projected gradient algorithm is developed for solving the latter problem when it is not feasible to explicitly assemble the interface operator. When implemented on local memory multiprocessors, the proposed methodology requires less interprocessor communication than the classical method of substructuring. It is also suitable for parallel/vector computers with shared memory and compares favorably with factorization based parallel direct methods.

  5. On Lu Factorization Algorithm With Multipliers | Ntekim | Global ...

    African Journals Online (AJOL)

    Various algorithm such as Doolittle, Crouts and Cholesky's have been proposed to factor a square matrix into a product of L and U matrices, that is, to find L and U such that A = LU; where L and U are lower and upper triangular matrices respectively. These methods are derived by writing the general forms of L and U and the ...

  6. Double-Stage Delay Multiply and Sum Beamforming Algorithm: Application to Linear-Array Photoacoustic Imaging

    OpenAIRE

    Mozaffarzadeh, Moein; Mahloojifar, Ali; Orooji, Mahdi; Adabi, Saba; Nasiriavanaki, Mohammadreza

    2018-01-01

    Photoacoustic imaging (PAI) is an emerging medical imaging modality capable of providing high spatial resolution of Ultrasound (US) imaging and high contrast of optical imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm in PAI. However, using DAS beamformer leads to low resolution images and considerable contribution of off-axis signals. A new paradigm namely Delay-Multiply-and-Sum (DMAS), which was originally used as a reconstruction algorithm in confocal microwave imaging...

  7. A Fluid Structure Algorithm with Lagrange Multipliers to Model Free Swimming

    Science.gov (United States)

    Sahin, Mehmet; Dilek, Ezgi

    2017-11-01

    A new monolithic approach is prosed to solve the fluid-structure interaction (FSI) problem with Lagrange multipliers in order to model free swimming/flying. In the present approach, the fluid domain is modeled by the incompressible Navier-Stokes equations and discretized using an Arbitrary Lagrangian-Eulerian (ALE) formulation based on the stable side-centered unstructured finite volume method. The solid domain is modeled by the constitutive laws for the nonlinear Saint Venant-Kirchhoff material and the classical Galerkin finite element method is used to discretize the governing equations in a Lagrangian frame. In order to impose the body motion/deformation, the distance between the constraint pair nodes is imposed using the Lagrange multipliers, which is independent from the frame of reference. The resulting algebraic linear equations are solved in a fully coupled manner using a dual approach (null space method). The present numerical algorithm is initially validated for the classical FSI benchmark problems and then applied to the free swimming of three linked ellipses. The authors are grateful for the use of the computing resources provided by the National Center for High Performance Computing (UYBHM) under Grant Number 10752009 and the computing facilities at TUBITAK-ULAKBIM, High Performance and Grid Computing Center.

  8. Double-Stage Delay Multiply and Sum Beamforming Algorithm Applied to Ultrasound Medical Imaging.

    Science.gov (United States)

    Mozaffarzadeh, Moein; Sadeghi, Masume; Mahloojifar, Ali; Orooji, Mahdi

    2018-03-01

    In ultrasound (US) imaging, delay and sum (DAS) is the most common beamformer, but it leads to low-quality images. Delay multiply and sum (DMAS) was introduced to address this problem. However, the reconstructed images using DMAS still suffer from the level of side lobes and low noise suppression. Here, a novel beamforming algorithm is introduced based on expansion of the DMAS formula. We found that there is a DAS algebra inside the expansion, and we proposed use of the DMAS instead of the DAS algebra. The introduced method, namely double-stage DMAS (DS-DMAS), is evaluated numerically and experimentally. The quantitative results indicate that DS-DMAS results in an approximately 25% lower level of side lobes compared with DMAS. Moreover, the introduced method leads to 23%, 22% and 43% improvement in signal-to-noise ratio, full width at half-maximum and contrast ratio, respectively, compared with the DMAS beamformer. Copyright © 2018. Published by Elsevier Inc.

  9. A composite experimental dynamic substructuring method based on partitioned algorithms and localized Lagrange multipliers

    Science.gov (United States)

    Abbiati, Giuseppe; La Salandra, Vincenzo; Bursi, Oreste S.; Caracoglia, Luca

    2018-02-01

    Successful online hybrid (numerical/physical) dynamic substructuring simulations have shown their potential in enabling realistic dynamic analysis of almost any type of non-linear structural system (e.g., an as-built/isolated viaduct, a petrochemical piping system subjected to non-stationary seismic loading, etc.). Moreover, owing to faster and more accurate testing equipment, a number of different offline experimental substructuring methods, operating both in time (e.g. the impulse-based substructuring) and frequency domains (i.e. the Lagrange multiplier frequency-based substructuring), have been employed in mechanical engineering to examine dynamic substructure coupling. Numerous studies have dealt with the above-mentioned methods and with consequent uncertainty propagation issues, either associated with experimental errors or modelling assumptions. Nonetheless, a limited number of publications have systematically cross-examined the performance of the various Experimental Dynamic Substructuring (EDS) methods and the possibility of their exploitation in a complementary way to expedite a hybrid experiment/numerical simulation. From this perspective, this paper performs a comparative uncertainty propagation analysis of three EDS algorithms for coupling physical and numerical subdomains with a dual assembly approach based on localized Lagrange multipliers. The main results and comparisons are based on a series of Monte Carlo simulations carried out on a five-DoF linear/non-linear chain-like systems that include typical aleatoric uncertainties emerging from measurement errors and excitation loads. In addition, we propose a new Composite-EDS (C-EDS) method to fuse both online and offline algorithms into a unique simulator. Capitalizing from the results of a more complex case study composed of a coupled isolated tank-piping system, we provide a feasible way to employ the C-EDS method when nonlinearities and multi-point constraints are present in the emulated system.

  10. Double-Stage Delay Multiply and Sum Beamforming Algorithm: Application to Linear-Array Photoacoustic Imaging.

    Science.gov (United States)

    Mozaffarzadeh, Moein; Mahloojifar, Ali; Orooji, Mahdi; Adabi, Saba; Nasiriavanaki, Mohammadreza

    2018-01-01

    Photoacoustic imaging (PAI) is an emerging medical imaging modality capable of providing high spatial resolution of Ultrasound (US) imaging and high contrast of optical imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm in PAI. However, using DAS beamformer leads to low resolution images and considerable contribution of off-axis signals. A new paradigm namely delay-multiply-and-sum (DMAS), which was originally used as a reconstruction algorithm in confocal microwave imaging, was introduced to overcome the challenges in DAS. DMAS was used in PAI systems and it was shown that this algorithm results in resolution improvement and sidelobe degrading. However, DMAS is still sensitive to high levels of noise, and resolution improvement is not satisfying. Here, we propose a novel algorithm based on DAS algebra inside DMAS formula expansion, double stage DMAS (DS-DMAS), which improves the image resolution and levels of sidelobe, and is much less sensitive to high level of noise compared to DMAS. The performance of DS-DMAS algorithm is evaluated numerically and experimentally. The resulted images are evaluated qualitatively and quantitatively using established quality metrics including signal-to-noise ratio (SNR), full-width-half-maximum (FWHM) and contrast ratio (CR). It is shown that DS-DMAS outperforms DAS and DMAS at the expense of higher computational load. DS-DMAS reduces the lateral valley for about 15 dB and improves the SNR and FWHM better than 13% and 30%, respectively. Moreover, the levels of sidelobe are reduced for about 10 dB in comparison with those in DMAS.

  11. A New Optimization Approach for Maximizing the Photovoltaic Panel Power Based on Genetic Algorithm and Lagrange Multiplier Algorithm

    Directory of Open Access Journals (Sweden)

    Mahdi M. M. El-Arini

    2013-01-01

    Full Text Available In recent years, the solar energy has become one of the most important alternative sources of electric energy, so it is important to operate photovoltaic (PV panel at the optimal point to obtain the possible maximum efficiency. This paper presents a new optimization approach to maximize the electrical power of a PV panel. The technique which is based on objective function represents the output power of the PV panel and constraints, equality and inequality. First the dummy variables that have effect on the output power are classified into two categories: dependent and independent. The proposed approach is a multistage one as the genetic algorithm, GA, is used to obtain the best initial population at optimal solution and this initial population is fed to Lagrange multiplier algorithm (LM, then a comparison between the two algorithms, GA and LM, is performed. The proposed technique is applied to solar radiation measured at Helwan city at latitude 29.87°, Egypt. The results showed that the proposed technique is applicable.

  12. Linear-Array Photoacoustic Imaging Using Minimum Variance-Based Delay Multiply and Sum Adaptive Beamforming Algorithm

    OpenAIRE

    Mozaffarzadeh, Moein; Mahloojifar, Ali; Orooji, Mahdi; Kratkiewicz, Karl; Adabi, Saba; Nasiriavanaki, Mohammadreza

    2017-01-01

    In Photoacoustic imaging (PA), Delay-and-Sum (DAS) beamformer is a common beamforming algorithm having a simple implementation. However, it results in a poor resolution and high sidelobes. To address these challenges, a new algorithm namely Delay-Multiply-and-Sum (DMAS) was introduced having lower sidelobes compared to DAS. To improve the resolution of DMAS, a novel beamformer is introduced using Minimum Variance (MV) adaptive beamforming combined with DMAS, so-called Minimum Variance-Based D...

  13. Three-Dimensional Photoacoustic Tomography using Delay Multiply and Sum Beamforming Algorithm

    OpenAIRE

    Paridar, Roya; Mozaffarzadeh, Moein; Mahloojifar, Ali; Nasiriavanaki, Mohammadreza; Orooji, Mahdi

    2018-01-01

    Photoacoustic imaging (PAI), is a promising medical imaging technique that provides the high contrast of the optical imaging and the resolution of ultrasound (US) imaging. Among all the methods, Three-dimensional (3D) PAI provides a high resolution and accuracy. One of the most common algorithms for 3D PA image reconstruction is delay-and-sum (DAS). However, the quality of the reconstructed image obtained from this algorithm is not satisfying, having high level of sidelobes and a wide mainlob...

  14. RegExpBlasting (REB), a Regular Expression Blasting algorithm based on multiply aligned sequences

    OpenAIRE

    Rubino, Francesco; Attimonelli, Marcella

    2009-01-01

    Background One of the most frequent uses of bioinformatics tools concerns functional characterization of a newly produced nucleotide sequence (a query sequence) by applying Blast or FASTA against a set of sequences (the subject sequences). However, in some specific contexts, it is useful to compare the query sequence against a cluster such as a MultiAlignment (MA). We present here the RegExpBlasting (REB) algorithm, which compares an unclassified sequence with a dataset of patterns defined by...

  15. Linear-array photoacoustic imaging using minimum variance-based delay multiply and sum adaptive beamforming algorithm.

    Science.gov (United States)

    Mozaffarzadeh, Moein; Mahloojifar, Ali; Orooji, Mahdi; Kratkiewicz, Karl; Adabi, Saba; Nasiriavanaki, Mohammadreza

    2018-02-01

    In photoacoustic imaging, delay-and-sum (DAS) beamformer is a common beamforming algorithm having a simple implementation. However, it results in a poor resolution and high sidelobes. To address these challenges, a new algorithm namely delay-multiply-and-sum (DMAS) was introduced having lower sidelobes compared to DAS. To improve the resolution of DMAS, a beamformer is introduced using minimum variance (MV) adaptive beamforming combined with DMAS, so-called minimum variance-based DMAS (MVB-DMAS). It is shown that expanding the DMAS equation results in multiple terms representing a DAS algebra. It is proposed to use the MV adaptive beamformer instead of the existing DAS. MVB-DMAS is evaluated numerically and experimentally. In particular, at the depth of 45 mm MVB-DMAS results in about 31, 18, and 8 dB sidelobes reduction compared to DAS, MV, and DMAS, respectively. The quantitative results of the simulations show that MVB-DMAS leads to improvement in full-width-half-maximum about 96%, 94%, and 45% and signal-to-noise ratio about 89%, 15%, and 35% compared to DAS, DMAS, MV, respectively. In particular, at the depth of 33 mm of the experimental images, MVB-DMAS results in about 20 dB sidelobes reduction in comparison with other beamformers. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

  16. Linear-array photoacoustic imaging using minimum variance-based delay multiply and sum adaptive beamforming algorithm

    Science.gov (United States)

    Mozaffarzadeh, Moein; Mahloojifar, Ali; Orooji, Mahdi; Kratkiewicz, Karl; Adabi, Saba; Nasiriavanaki, Mohammadreza

    2018-02-01

    In photoacoustic imaging, delay-and-sum (DAS) beamformer is a common beamforming algorithm having a simple implementation. However, it results in a poor resolution and high sidelobes. To address these challenges, a new algorithm namely delay-multiply-and-sum (DMAS) was introduced having lower sidelobes compared to DAS. To improve the resolution of DMAS, a beamformer is introduced using minimum variance (MV) adaptive beamforming combined with DMAS, so-called minimum variance-based DMAS (MVB-DMAS). It is shown that expanding the DMAS equation results in multiple terms representing a DAS algebra. It is proposed to use the MV adaptive beamformer instead of the existing DAS. MVB-DMAS is evaluated numerically and experimentally. In particular, at the depth of 45 mm MVB-DMAS results in about 31, 18, and 8 dB sidelobes reduction compared to DAS, MV, and DMAS, respectively. The quantitative results of the simulations show that MVB-DMAS leads to improvement in full-width-half-maximum about 96%, 94%, and 45% and signal-to-noise ratio about 89%, 15%, and 35% compared to DAS, DMAS, MV, respectively. In particular, at the depth of 33 mm of the experimental images, MVB-DMAS results in about 20 dB sidelobes reduction in comparison with other beamformers.

  17. THE IDENTIFICATION ALGORITHM OF METROLOGICAL CHARACTERISTICS OF WIDE-RANGE PHOTOVOLTAIC SEMICONDUCTOR CONVERTERS WITH MULTIPLY IMPURITIES

    Directory of Open Access Journals (Sweden)

    O. K. Gusev

    2011-01-01

    Full Text Available Metrological features of photovoltaic semiconductor converters (PSC based on semiconductors with the multiple-charge impurities are investigated in a wide range of power densities of optical radiation. The algorithm of the measurement procedure of the metrological characteristics of PSC is introduced not only at low densities of optical power, but at high, taking into account the boundary of nonlinear recombination. The estimation of accuracy of feature finding of the metrological characteristics PSC based on semiconductors with the multiple-charge impurities, is carried out, taking into consideration the area of nonlinear recombination. 

  18. Experimental validation of a novel reconstruction algorithm for electrical impedance tomography based on backprojection of Lagrange multipliers.

    Science.gov (United States)

    Bayford, R; Hanquan, Y; Boone, K; Holder, D S

    1995-08-01

    A novel approach to image reconstruction for electrical impedance tomography (EIT) has been developed. It is based on a constrained optimization technique for the reconstruction of difference resistivity images without finite-element modelling. It solves the inverse problem by optimizing a cost function under constraints, in the form of normalized boundary potentials. Its application to the neighboring data collection method is presented here. Mathematical models are developed according to specified criteria. These express the reconstructed image in terms of one-dimensional Lagrange multiplier functions. The reconstruction problem becomes one of estimating these functions from normalized boundary potentials. This model is based on a cost criterion of the minimization of the variance between the reconstructed and the true resistivity distributions. The algorithm was tested on data collected in a cylindrical saline-filled tank. A polyacrylamide rod was placed in various positions with or without a peripheral plaster of Paris ring in place. This was intended to resemble the conditions during EIT of epileptic seizures recorded with scalp or cortical electrodes in the human head. One advantage of this approach is that compensation for non-uniform initial conditions may be made, as this is a significant problem in imaging cerebral activity through the skull.

  19. Multiplying Money

    Directory of Open Access Journals (Sweden)

    Garry Jacobs

    2013-05-01

    Full Text Available This article is not a comprehensive factual history of money as an economic instrument. It aims rather to present an essential psychological history of the power of money as a social organization or social technology. It explores the catalytic role of money in the development of society and its ever-increasing capacity for accomplishment in both economic and non-economic fields. This perspective focuses attention on the unutilized potential for harnessing the social power of money for promoting full employment, global development and human welfare. The title ‘multiplying money’ is intended to convey the idea that this untapped potential is exponential in nature. In order to recognize it, some fundamental misconceptions about the nature of money, how it is created and on what it is based need to be examined. This is the second article in a series.

  20. Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxin.

    Science.gov (United States)

    Ticehurst, John R; Aird, Deborah Z; Dam, Lisa M; Borek, Anita P; Hargrove, John T; Carroll, Karen C

    2006-03-01

    We evaluated a two-step algorithm for detecting toxigenic Clostridium difficile: an enzyme immunoassay for glutamate dehydrogenase antigen (Ag-EIA) and then, for antigen-positive specimens, a concurrent cell culture cytotoxicity neutralization assay (CCNA). Antigen-negative results were > or = 99% predictive of CCNA negativity. Because the Ag-EIA reduced cell culture workload by approximately 75 to 80% and two-step testing was complete in CCNA alone had been performed on all 5,887 specimens.

  1. Multiplying dimensions

    CERN Multimedia

    2013-01-01

    A few weeks ago, I had a vague notion of what TED was, and how it worked, but now I’m a confirmed fan. It was my privilege to host CERN’s first TEDx event last Friday, and I can honestly say that I can’t remember a time when I was exposed to so much brilliance in such a short time.   TEDxCERN was designed to give a platform to science. That’s why we called it Multiplying Dimensions – a nod towards the work we do here, while pointing to the broader importance of science in society. We had talks ranging from the most subtle pondering on the nature of consciousness to an eighteen year old researcher urging us to be patient, and to learn from our mistakes. We had musical interludes that included encounters between the choirs of local schools and will.i.am, between an Israeli pianist and an Iranian percussionist, and between Grand Opera and high humour. And although I opened the event by announcing it as a day off from physics, we had a quite brill...

  2. Effective Detection of Toxigenic Clostridium difficile by a Two-Step Algorithm Including Tests for Antigen and Cytotoxin

    OpenAIRE

    Ticehurst, John R.; Aird, Deborah Z.; Dam, Lisa M.; Borek, Anita P.; Hargrove, John T.; Carroll, Karen C.

    2006-01-01

    We evaluated a two-step algorithm for detecting toxigenic Clostridium difficile: an enzyme immunoassay for glutamate dehydrogenase antigen (Ag-EIA) and then, for antigen-positive specimens, a concurrent cell culture cytotoxicity neutralization assay (CCNA). Antigen-negative results were ≥99% predictive of CCNA negativity. Because the Ag-EIA reduced cell culture workload by ≈75 to 80% and two-step testing was complete in ≤3 days, we decided that this algorithm would be effective. Over 6 months...

  3. Single electron based binary multipliers with overflow detection ...

    African Journals Online (AJOL)

    electron based device. Multipliers with overflow detection based on serial and parallel prefix computation algorithm are elaborately discussed analytically and designed. The overflow detection circuits works in parallel with a simplified multiplier to ...

  4. Theory of Sobolev multipliers

    CERN Document Server

    Shaposhnikova, Tatyana O

    2008-01-01

    Offers a comprehensive exposition of the theory of pointwise multipliers acting in pairs of spaces of differentiable functions. This book covers topics such as: trace inequalities, analytic characterization of multipliers, relations between spaces of Sobolev multipliers and other function spaces, and maximal subalgebras of multiplier spaces.

  5. Pressure multiplying dispenser

    Science.gov (United States)

    DeFord, Henry S.; Moss, Owen R.

    1986-01-01

    A pressure multiplying dispenser for delivering fluid, preferably as a spray to the atmosphere, from a source of fluid, preferably a spray bottle, is described. The dispenser includes in combination a hollow cylindrical member, a nozzle delivery tube within the cylindrical member and a hollow actuator piston slideable within the cylindrical member which acts to multiply the pressure of a squeeze applied to the spray bottle.

  6. The Multiply Handicapped Child.

    Science.gov (United States)

    Wolf, James M., Ed.; Anderson, Robert M., Ed.

    Articles presented in the area of the medical and educational challenge of the multiply handicapped child are an overview of the problem, the increasing challenge, congenital malformations, children whose mothers had rubella, prematurity and deafness, the epidemiology of reproductive casualty, and new education for old problems. Discussions of…

  7. The Multiplier Effect.

    Science.gov (United States)

    Flowers, William L., Jr.; Harris, John B.

    1981-01-01

    The multiplier effect is discussed as it applies to the field of continuing education. The authors' main point is that one grant or contract can, and should, be used as the basis for building organizational competencies and capabilities that will secure other funds. (Author/CT)

  8. Why Multiply by "g"?

    Science.gov (United States)

    Nelson, Jane Bray

    2012-01-01

    As a new physics teacher, I was explaining how to find the weight of an object sitting on a table near the surface of the Earth. It bothered me when a student asked, "The object is not accelerating so why do you multiply the mass of the object by the acceleration due to gravity?" I answered something like, "That's true, but if the table were not…

  9. A Radix-10 Combinational Multiplier

    DEFF Research Database (Denmark)

    Lang, Tomas; Nannarelli, Alberto

    2006-01-01

    reduces the number of partial product precomputations and uses counters to eliminate the need of the decimal equivalent of a 4:2 adder. The results of the implementation show that the combinational decimal multiplier offers a good compromise between latency and area when compared to other decimal multiply...... units and to binary double-precision multipliers....

  10. Prostate cancer prediction using the random forest algorithm that takes into account transrectal ultrasound findings, age, and serum levels of prostate-specific antigen

    Directory of Open Access Journals (Sweden)

    Li-Hong Xiao

    2017-01-01

    Full Text Available The aim of this study is to evaluate the ability of the random forest algorithm that combines data on transrectal ultrasound findings, age, and serum levels of prostate-specific antigen to predict prostate carcinoma. Clinico-demographic data were analyzed for 941 patients with prostate diseases treated at our hospital, including age, serum prostate-specific antigen levels, transrectal ultrasound findings, and pathology diagnosis based on ultrasound-guided needle biopsy of the prostate. These data were compared between patients with and without prostate cancer using the Chi-square test, and then entered into the random forest model to predict diagnosis. Patients with and without prostate cancer differed significantly in age and serum prostate-specific antigen levels (P < 0.001, as well as in all transrectal ultrasound characteristics (P < 0.05 except uneven echo (P = 0.609. The random forest model based on age, prostate-specific antigen and ultrasound predicted prostate cancer with an accuracy of 83.10%, sensitivity of 65.64%, and specificity of 93.83%. Positive predictive value was 86.72%, and negative predictive value was 81.64%. By integrating age, prostate-specific antigen levels and transrectal ultrasound findings, the random forest algorithm shows better diagnostic performance for prostate cancer than either diagnostic indicator on its own. This algorithm may help improve diagnosis of the disease by identifying patients at high risk for biopsy.

  11. Prostate-specific antigen (PSA) density in the diagnostic algorithm of prostate cancer.

    Science.gov (United States)

    Nordström, Tobias; Akre, Olof; Aly, Markus; Grönberg, Henrik; Eklund, Martin

    2018-04-01

    Screening for prostate cancer using prostate-specific antigen (PSA) alone leads to un-necessary biopsying and overdiagnosis. PSA density is easily accessible, but early evidence on its use for biopsy decisions was conflicting and use of PSA density is not commonly recommended in guidelines. We analyzed biopsy outcomes in 5291 men in the population-based STHLM3 study with PSA ≥ 3 ng/ml and ultrasound-guided prostate volume measurements by using percentages and regression models. PSA density was calculated as total PSA (ng/ml) divided by prostate volume (ml). Main endpoint was clinically significant cancer (csPCa) defined as Gleason Score ≥ 7. The median PSA-density was 0.10 ng/ml 2 (IQR 0.075-0.14). PSA-density was associated with the risk of finding csPCa both with and without adjusting for the additional clinical information age, family history, previous biopsies, total PSA and free/total PSA (OR 1.06; 95% CI:1.05-1.07 and OR 1.07, 95% CI 1.06-1.08). Discrimination for csPCa was better when PSA density was added to a model with additional clinical information (AUC 0.75 vs. 0.73, P PSA-density. Omitting prostate biopsy for men with PSA-density ≤0.07 ng/ml 2 would save 19.7% of biopsy procedures, while missing 6.9% of csPCa. PSA-density cutoffs of 0.10 ng/ml 2 and 0.15 ng/ml 2 resulted in detection of 77% (729/947) and 49% (461/947) of Gleason Score ≥7 tumors. PSA-density might inform biopsy decisions, and spare some men from the morbidity associated with a prostate biopsy and diagnosis of low-grade prostate cancer.

  12. Comparative Study of Approximate Multipliers

    OpenAIRE

    Masadeh, Mahmoud; Hasan, Osman; Tahar, Sofiene

    2018-01-01

    Approximate multipliers are widely being advocated for energy-efficient computing in applications that exhibit an inherent tolerance to inaccuracy. However, the inclusion of accuracy as a key design parameter, besides the performance, area and power, makes the identification of the most suitable approximate multiplier quite challenging. In this paper, we identify three major decision making factors for the selection of an approximate multipliers circuit: (1) the type of approximate full adder...

  13. UWB delay and multiply receiver

    Energy Technology Data Exchange (ETDEWEB)

    Dallum, Gregory E.; Pratt, Garth C.; Haugen, Peter C.; Romero, Carlos E.

    2013-09-10

    An ultra-wideband (UWB) delay and multiply receiver is formed of a receive antenna; a variable gain attenuator connected to the receive antenna; a signal splitter connected to the variable gain attenuator; a multiplier having one input connected to an undelayed signal from the signal splitter and another input connected to a delayed signal from the signal splitter, the delay between the splitter signals being equal to the spacing between pulses from a transmitter whose pulses are being received by the receive antenna; a peak detection circuit connected to the output of the multiplier and connected to the variable gain attenuator to control the variable gain attenuator to maintain a constant amplitude output from the multiplier; and a digital output circuit connected to the output of the multiplier.

  14. Biospheric Changes are Threat Multipliers

    OpenAIRE

    Cairns, John

    2010-01-01

    A threat multiplier is defined as another agent that impacts a current situation, creating an additional set of problems while also making existing problems worse. Sometimes a seemingly innocent change in the biosphere can cause major alterations and become a threat multiplier. Because the biosphere is a highly interactive system, damage to a single component, like the ocean for example, will produce a ripple effect throughout the entire system. In order for humans to eliminate threat multip...

  15. Effective switching frequency multiplier inverter

    Science.gov (United States)

    Su, Gui-Jia; Peng, Fang Z.

    2007-08-07

    A switching frequency multiplier inverter for low inductance machines that uses parallel connection of switches and each switch is independently controlled according to a pulse width modulation scheme. The effective switching frequency is multiplied by the number of switches connected in parallel while each individual switch operates within its limit of switching frequency. This technique can also be used for other power converters such as DC/DC, AC/DC converters.

  16. Algorithms

    Indian Academy of Sciences (India)

    have been found in Vedic Mathematics which are dated much before Euclid's algorithm. A programming language Is used to describe an algorithm for execution on a computer. An algorithm expressed using a programming language Is called a program. From activities 1-3, we can observe that: • Each activity is a command.

  17. Algorithms

    Indian Academy of Sciences (India)

    algorithms such as synthetic (polynomial) division have been found in Vedic Mathematics which are dated much before Euclid's algorithm. A programming language ... ·1 x:=sln(theta) x : = sm(theta) 1. ~. Idl d.t Read A.B,C. ~ lei ~ Print x.y.z. L;;;J. Figure 2 Symbols used In flowchart language to rep- resent Assignment, Read.

  18. Algorithms

    Indian Academy of Sciences (India)

    In the previous articles, we have discussed various common data-structures such as arrays, lists, queues and trees and illustrated the widely used algorithm design paradigm referred to as 'divide-and-conquer'. Although there has been a large effort in realizing efficient algorithms, there are not many universally accepted ...

  19. Time efficient signed Vedic multiplier using redundant binary representation

    Directory of Open Access Journals (Sweden)

    Ranjan Kumar Barik

    2017-03-01

    Full Text Available This study presents a high-speed signed Vedic multiplier (SVM architecture using redundant binary (RB representation in Urdhva Tiryagbhyam (UT sutra. This is the first ever effort towards extension of Vedic algorithms to the signed numbers. The proposed multiplier architecture solves the carry propagation issue in UT sutra, as carry free addition is possible in RB representation. The proposed design is coded in VHDL and synthesised in Xilinx ISE 14.4 of various FPGA devices. The proposed SVM architecture has better speed performances as compared with various state-of-the-art conventional as well as Vedic architectures.

  20. Multiplied Environmental Literacy. Final Report.

    Science.gov (United States)

    Buethe, Chris

    This booklet presents a pupil-oriented program designed to increase the environmental literacy of teachers and students in Indiana schools through a programmed multiplier effect. Junior and senior high school science teachers were prepared to teach students the meanings of 44 selected environmental terms and related concepts. Those teachers then…

  1. Last multipliers on Lie algebroids

    Indian Academy of Sciences (India)

    Abstract. In this paper we extend the theory of last multipliers as solutions of the. Liouville's transport equation to Lie algebroids with their top exterior power as trivial line bundle (previously developed for vector fields and multivectors). We define the notion of exact section and the Liouville equation on Lie algebroids.

  2. Bilinear modeling via augmented Lagrange multipliers (BALM).

    Science.gov (United States)

    Del Bue, Alessio; Xavier, João; Agapito, Lourdes; Paladini, Marco

    2012-08-01

    This paper presents a unified approach to solve different bilinear factorization problems in computer vision in the presence of missing data in the measurements. The problem is formulated as a constrained optimization where one of the factors must lie on a specific manifold. To achieve this, we introduce an equivalent reformulation of the bilinear factorization problem that decouples the core bilinear aspect from the manifold specificity. We then tackle the resulting constrained optimization problem via Augmented Lagrange Multipliers. The strength and the novelty of our approach is that this framework can seamlessly handle different computer vision problems. The algorithm is such that only a projector onto the manifold constraint is needed. We present experiments and results for some popular factorization problems in computer vision such as rigid, non-rigid, and articulated Structure from Motion, photometric stereo, and 2D-3D non-rigid registration.

  3. Algorithms

    Indian Academy of Sciences (India)

    In the program shown in Figure 1, we have repeated the algorithm. M times and we can make the following observations. Each block is essentially a different instance of "code"; that is, the objects differ by the value to which N is initialized before the execution of the. "code" block. Thus, we can now avoid the repetition of the ...

  4. Algorithms

    Indian Academy of Sciences (India)

    algorithms built into the computer corresponding to the logic- circuit rules that are used to .... For the purpose of carrying ou t ari thmetic or logical operations the memory is organized in terms .... In fixed point representation, one essentially uses integer arithmetic operators assuming the binary point to be at some point other ...

  5. Switched-Capacitor Voltage Multiplier

    Science.gov (United States)

    Sridharan, Govind

    1991-01-01

    Dc-to-dc power converter multiplies input supply potential by factor of nearly 40. Design does not make use of transformers or inductors but effects voltage boost-up by capacitive energy transfer. Circuit primarily made up of banks of capacitors, connected by network of integrated-circuit relays. Converter functionally linear voltage amplifier with fixed gain figure. Bipolar in operation. Output fully floating, and excellent dc isolation between input and output terminals.

  6. Multiplier Models in Stochastic DEA

    Directory of Open Access Journals (Sweden)

    Mahnaz Mirbolouki

    2014-05-01

    Full Text Available Data Envelopment Analysis (DEA is a data-oriented performance evaluation method which has treated data as being deterministic. Throughout applications managers may encounter the data which are not recognized deterministically. In this paper a deterministic version of stochastic CCR multiplier model based on chance constrained programming approach is presented. The advantage of this method is that the stochastic essence of input-output variables has been taken into account. Using numerical example, we will demonstrate how this method works.

  7. Karatsuba-Ofman Multiplier with Integrated Modular Reduction for GF(2m

    Directory of Open Access Journals (Sweden)

    CUEVAS-FARFAN, E.

    2013-05-01

    Full Text Available In this paper a novel GF(2m multiplier based on Karatsuba-Ofman Algorithm is presented. A binary field multiplication in polynomial basis is typically viewed as a two steps process, a polynomial multiplication followed by a modular reduction step. This research proposes a modification to the original Karatsuba-Ofman Algorithm in order to integrate the modular reduction inside the polynomial multiplication step. Modular reduction is achieved by using parallel linear feedback registers. The new algorithm is described in detail and results from a hardware implementation on FPGA technology are discussed. The hardware architecture is described in VHDL and synthesized for a Virtex-6 device. Although the proposed field multiplier can be implemented for arbitrary finite fields, the targeted finite fields are recommended for Elliptic Curve Cryptography. Comparing other KOA multipliers, our proposed multiplier uses 36% less area resources and improves the maximum delay in 10%.

  8. 16QAM blind equalization via maximum entropy density approximation technique and nonlinear Lagrange multipliers.

    Science.gov (United States)

    Mauda, R; Pinchas, M

    2014-01-01

    Recently a new blind equalization method was proposed for the 16QAM constellation input inspired by the maximum entropy density approximation technique with improved equalization performance compared to the maximum entropy approach, Godard's algorithm, and others. In addition, an approximated expression for the minimum mean square error (MSE) was obtained. The idea was to find those Lagrange multipliers that bring the approximated MSE to minimum. Since the derivation of the obtained MSE with respect to the Lagrange multipliers leads to a nonlinear equation for the Lagrange multipliers, the part in the MSE expression that caused the nonlinearity in the equation for the Lagrange multipliers was ignored. Thus, the obtained Lagrange multipliers were not those Lagrange multipliers that bring the approximated MSE to minimum. In this paper, we derive a new set of Lagrange multipliers based on the nonlinear expression for the Lagrange multipliers obtained from minimizing the approximated MSE with respect to the Lagrange multipliers. Simulation results indicate that for the high signal to noise ratio (SNR) case, a faster convergence rate is obtained for a channel causing a high initial intersymbol interference (ISI) while the same equalization performance is obtained for an easy channel (initial ISI low).

  9. 16QAM Blind Equalization via Maximum Entropy Density Approximation Technique and Nonlinear Lagrange Multipliers

    Directory of Open Access Journals (Sweden)

    R. Mauda

    2014-01-01

    Full Text Available Recently a new blind equalization method was proposed for the 16QAM constellation input inspired by the maximum entropy density approximation technique with improved equalization performance compared to the maximum entropy approach, Godard’s algorithm, and others. In addition, an approximated expression for the minimum mean square error (MSE was obtained. The idea was to find those Lagrange multipliers that bring the approximated MSE to minimum. Since the derivation of the obtained MSE with respect to the Lagrange multipliers leads to a nonlinear equation for the Lagrange multipliers, the part in the MSE expression that caused the nonlinearity in the equation for the Lagrange multipliers was ignored. Thus, the obtained Lagrange multipliers were not those Lagrange multipliers that bring the approximated MSE to minimum. In this paper, we derive a new set of Lagrange multipliers based on the nonlinear expression for the Lagrange multipliers obtained from minimizing the approximated MSE with respect to the Lagrange multipliers. Simulation results indicate that for the high signal to noise ratio (SNR case, a faster convergence rate is obtained for a channel causing a high initial intersymbol interference (ISI while the same equalization performance is obtained for an easy channel (initial ISI low.

  10. Area efficient radix 4/sup 2/ 64 point pipeline fft architecture using modified csd multiplier

    International Nuclear Information System (INIS)

    Siddiq, F.; Muhammad, T.; Iqbal, M.

    2014-01-01

    A modified Fast Fourier Transform (FFT) based radix 42 algorithm for Orthogonal Frequency Division Multiplexing (OFDM) systems is presented. When compared with similar schemes like Canonic signed digit (CSD) Constant Multiplier, the modified CSD multiplier can provide a improvement of more than 36% in terms of multiplicative complexity. In Comparison of area being occupied the amount of Full adders is reduced by 32% and amount of half adders is reduced by 42%. The modified CSD multiplier scheme is implemented on Xilinx ISE 10.1 using Spartan-III XC3S1000 FPGA as a target device. The synthesis results of modified CSD Multiplier on Xilinx show efficient Twiddle Factor ROM Design and effective area reduction in comparison to CSD constant multiplier. (author)

  11. GEM the gas electron multiplier

    CERN Document Server

    Sauli, Fabio

    1997-01-01

    We describe the basic structure and operation of a new device, the Gas Electron Multiplier. Consisting in a polymer foil, metal-clad on both sides and perforated by a high density of holes, the GEM mesh allows to pre-amplify charges released in the gas with good uniformity and energy. Coupled to a micro-strip plate, the pre-amplification element allows to preserve high rate capability and resolution at considerably lower operating voltages, thus completely eliminating discharges and instabilities. Several GEM grids can be operated in cascade; charge gains are large enough to allow detection of signals in the ionization mode on the last element, permitting the use of a simple printed circuit as read-out electrode. Two-dimensional read-out can then be easily implemented. A new generation of simple, reliable and cheap fast position sensitive detectors seems at hand.

  12. Different I/O Standard and Technology Based Thermal Aware Energy Efficient Vedic Multiplier Design for Green Wireless Communication on FPGA

    DEFF Research Database (Denmark)

    Goswami, Kavita; Pandey, Bishwajeet; Kumar, Tanesh

    2017-01-01

    This paper deals with low power multiplier design that plays a significant role in green wireless communications systems. Over the period of time, researchers have proposed various multiplier designs in order to get high speed. Vedic multiplier is considered as one of the low power multiplier along...... with high speed as compared with traditional array and booth multipliers. Vedic Multiplier contains a total of sixteen algorithms/sutras for predominantly logical operations. This research focuses on thermal aspects and energy efficiency of wireless communications systems with the thermal aware low power...... design of Vedic Multiplier. Temperature plays an important role on the performance of any device. The primary purpose of this research is to enhance the thermal stability of the wireless communications. Energy efficient IO standards are used to decrease the power dissipation of Vedic Multiplier...

  13. Optimizing strassen matrix multiply on GPUs

    KAUST Repository

    ul Hasan Khan, Ayaz

    2015-06-01

    © 2015 IEEE. Many core systems are basically designed for applications having large data parallelism. Strassen Matrix Multiply (MM) can be formulated as a depth first (DFS) traversal of a recursion tree where all cores work in parallel on computing each of the NxN sub-matrices that reduces storage at the detriment of large data motion to gather and aggregate the results. We propose Strassen and Winograd algorithms (S-MM and W-MM) based on three optimizations: a set of basic algebra functions to reduce overhead, invoking efficient library (CUBLAS 5.5), and parameter-tuning of parametric kernel to improve resource occupancy. On GPUs, W-MM and S-MM with one recursion level outperform CUBLAS 5.5 Library with up to twice as faster for large arrays satisfying N>=2048 and N>=3072, respectively. Compared to NVIDIA SDK library, S-MM and W-MM achieved a speedup between 20x to 80x for the above arrays. The proposed approach can be used to enhance the performance of CUBLAS and MKL libraries.

  14. Operator valued integral multiplier functions | Fourie | Quaestiones ...

    African Journals Online (AJOL)

    In recent years, several papers were devoted to the study of (p, q)-summing sequences of operators and their applications in the theory of Banach spaces. In the present paper we initiate a similar study of “integral multiplier functions”, thereby introducing these spaces of operator valued multiplier functions as normed spaces ...

  15. Spin sensitivity of a channel electron multiplier

    International Nuclear Information System (INIS)

    Scholten, R.E.; McClelland, J.J.; Kelley, M.H.; Celotta, R.J.

    1988-01-01

    We report direct measurements of the sensitivity of a channel electron multiplier to electrons with different spin orientations. Four regions of the multiplier cone were examined using polarized electrons at 100-eV incident energy. Pulse counting and analog modes of operation were both investigated and in each case the observed spin effects were less than 0.5%

  16. Otanps synapse linear relation multiplier circuit

    International Nuclear Information System (INIS)

    Chible, H.

    2008-01-01

    In this paper, a four quadrant VLSI analog multiplier will be proposed, in order to be used in the implementation of the neurons and synapses modules of the artificial neural networks. The main characteristics of this multiplier are the small silicon area and the low power consumption and the high value of the weight input voltage. (author)

  17. Novel insights into the multiplier rule

    NARCIS (Netherlands)

    J. Brinkhuis (Jan); V. Protassov (Vladimir)

    2005-01-01

    textabstractWe present the Lagrange multiplier rule, one of the basic optimization methods, in a new way. Novel features include: • Explanation of the true source of the power of the rule: reversal of tasks, but not the use of multipliers. • A natural proof based on a simple picture, but not the

  18. The gas electron multiplier (GEM)

    CERN Document Server

    Bouclier, Roger; Dominik, Wojciech; Hoch, M; Labbé, J C; Million, Gilbert; Ropelewski, Leszek; Sauli, Fabio; Sharma, A

    1996-01-01

    We describe operating priciples and results obtained with a new detector component: the Gas Electrons Multiplier (GEM). Consisting of a thin composite sheet with two metal layers separated by a thin insulator, and pierced by a regular matrix of open channels, the GEM electrode, inserted on the path of electrons in a gas detector, allows to transfer the charge with an amplification factor approaching ten. Uniform response and high rate capability are demonstrated. Coupled to another device, multiwire or micro-strip chamber, the GEM electrode permit to obtain higher gains or less critical operation; separation of the sensitive (conversion) volume and the detection volume has other advantages, as a built-in delay (useful for triggering purposes) and the possibility of applying high fields on the photo-cathode of ring imaging detectors to improve efficiency. Multiple GEM grids in the same gas volume allow to obtain large amplification factors in a succession of steps, leading to the realization of an effective ga...

  19. Special multipliers for treatment of radiometric information

    International Nuclear Information System (INIS)

    Vankov, L.

    1982-01-01

    All the devices of multiplying and dividing the parameters of two or more pulse flows or of a single pulse flow parameters of a constant have been united into a general class of ''special multipliers'' and they have been classified into two major groups: special multipliers with a single two cycles of processing. A general block scheme has been applied to the devices/and/ of each group, due to which a generalized theoretical analysis has been made and general relations for finding the major structural parameters in compliance with the required accuracy of the processing have been found. (authors)

  20. Calculated characteristics of multichannel photoelectron multipliers

    International Nuclear Information System (INIS)

    Vasil'chenko, V.G.; Dajkovskij, A.G.; Milova, N.V.; Rakhmatov, V.E.; Rykalin, V.I.

    1990-01-01

    Structural features and main calculated characteristics of some modifications of position-sensitive two-coordinate multichannel photoelectron multipliers (PEM) with plate-type multiplying systems are described. The presented PEM structures are free from direct optical and ion feedbacks, provide coordinate resolution ≅ 1 mm with efficiency of photoelectron detection ≅ 90%. Capabilities for using silicon field-effect photocathodes, providing electron extraction into vacuum, as well as prospects of using multichannel multiplying systems for readout of the data from solid detectors are considered

  1. Open-loop digital frequency multiplier

    Science.gov (United States)

    Moore, R. C.

    1977-01-01

    Monostable multivibrator is implemented by using digital integrated circuits where multiplier constant is too large for conventional phase-locked-loop integrated circuit. A 400 Hz clock is generated by divide-by-N counter from 1 Hz timing reference.

  2. Multipliers for continuous frames in Hilbert spaces

    International Nuclear Information System (INIS)

    Balazs, P; Bayer, D; Rahimi, A

    2012-01-01

    In this paper, we examine the general theory of continuous frame multipliers in Hilbert space. These operators are a generalization of the widely used notion of (discrete) frame multipliers. Well-known examples include anti-Wick operators, STFT multipliers or Calderón–Toeplitz operators. Due to the possible peculiarities of the underlying measure spaces, continuous frames do not behave quite as their discrete counterparts. Nonetheless, many results similar to the discrete case are proven for continuous frame multipliers as well, for instance compactness and Schatten-class properties. Furthermore, the concepts of controlled and weighted frames are transferred to the continuous setting. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Coherent states: mathematical and physical aspects’. (paper)

  3. Vacuum measuring system for channel electron multipliers

    Science.gov (United States)

    Urban, A.; Ritzinger, W.

    1982-03-01

    A system in which channel electron multipliers can be calibrated to be used as detectors of electrons or protons in space is described. The system consists of an electron gun built in a vacuum chamber and equipped with a control Faraday cup and a high impedance electrometer to measure electron fluxes. It contains an electron flux control with buffer amplifier, a proportional integration differentiation regulation unit, and a heating current power regulation. Detection efficiency dependency on the energy of the incident particles, the saturation that yields decreasing count rates at continuously increasing particle flux, or the statistical pulse height distribution giving information about well or restrictedly usuable multipliers can be measured. The optimum supply voltage of the multipliers at which small fluctuations do not cause any changes of the pulse height distribution, and the function count rates vs. supply voltage for selecting good or poor multipliers can also be determined.

  4. Clostridium difficile testing algorithms using glutamate dehydrogenase antigen and C. difficile toxin enzyme immunoassays with C. difficile nucleic acid amplification testing increase diagnostic yield in a tertiary pediatric population.

    Science.gov (United States)

    Ota, Kaede V; McGowan, Karin L

    2012-04-01

    We evaluated the performance of the rapid C. diff Quik Chek Complete's glutamate dehydrogenase antigen (GDH) and toxin A/B (CDT) tests in two algorithmic approaches for a tertiary pediatric population: algorithm 1 entailed initial testing with GDH/CDT followed by loop-mediated isothermal amplification (LAMP), and algorithm 2 entailed GDH/CDT followed by cytotoxicity neutralization assay (CCNA) for adjudication of discrepant GDH-positive/CDT-negative results. A true positive (TP) was defined as positivity by CCNA or positivity by LAMP plus another test (GDH, CDT, or the Premier C. difficile toxin A and B enzyme immunoassay [P-EIA]). A total of 141 specimens from 141 patients yielded 27 TPs and 19% prevalence. Sensitivity, specificity, positive predictive value, and negative predictive value were 56%, 100%, 100%, and 90% for P-EIA and 81%, 100%, 100%, and 96% for both algorithm 1 and algorithm 2. In summary, GDH-based algorithms detected C. difficile infections with superior sensitivity compared to P-EIA. The algorithms allowed immediate reporting of half of all TPs, but LAMP or CCNA was required to confirm the presence or absence of toxigenic C. difficile in GDH-positive/CDT-negative specimens.

  5. Economic Multipliers and Mega-Event Analysis

    OpenAIRE

    Victor Matheson

    2004-01-01

    Critics of economic impact studies that purport to show that mega-events such as the Olympics bring large benefits to the communities “lucky” enough to host them frequently cite the use of inappropriate multipliers as a primary reason why these impact studies overstate the true economic gains to the hosts of these events. This brief paper shows in a numerical example how mega-events may lead to inflated multipliers and exaggerated claims of economic benefits.

  6. Time-area efficient multiplier-free filter architectures for FPGA implementation

    DEFF Research Database (Denmark)

    Shajaan, Mohammad; Nielsen, Karsten; Sørensen, John Aasted

    1995-01-01

    Simultaneous design of multiplier-free filters and their hardware implementation in Xilinx field programmable gate array (XC4000) is presented. The filter synthesis method is a new approach based on cascade coupling of low order sections. The complexity of the design algorithm is 𝒪 (filter o...

  7. Ad Hoc Microphone Array Beamforming Using the Primal-Dual Method of Multipliers

    DEFF Research Database (Denmark)

    Tavakoli, Vincent Mohammad; Jensen, Jesper Rindom; Heusdens, Richard

    2016-01-01

    In the recent years, there have been increasing amount of researches aiming at optimal beamforming with ad hoc microphone arrays, mostly with fusion-based schemes. However, huge amount of computational complexity and communication overhead impede many of these algorithms from being useful in prac...... the distributed linearly-constrained minimum variance beamformer using the the state of the art primal-dual method of multipliers. We study the proposed algorithm with an experiment....

  8. Optical studies of multiply excited states

    International Nuclear Information System (INIS)

    Mannervik, S.

    1989-01-01

    Optical studies of multiply-excited states are reviewed with emphasis on emission spectroscopy. From optical measurements, properties such as excitation energies, lifetimes and autoionization widths can be determined with high accuracy, which constitutes a challenge for modern computational methods. This article mainly covers work on two-, three- and four-electron systems, but also sodium-like quartet systems. Furthermore, some comments are given on bound multiply-excited states in negative ions. Fine structure effects on transition wavelengths and lifetimes (autoionization) are discussed. In particular, the most recent experimental and theoretical studies of multiply-excited states are covered. Some remaining problems, which require further attention, are discussed in more detail. (orig.) With 228 refs

  9. Semigroups of Herz-Schur multipliers

    DEFF Research Database (Denmark)

    Knudby, Søren

    2014-01-01

    function (see Theorem 1.2). It is then shown that a (not necessarily proper) generator of a semigroup of Herz–Schur multipliers splits into a positive definite kernel and a conditionally negative definite kernel. We also show that the generator has a particularly pleasant form if and only if the group...... is amenable. In the second half of the paper we study semigroups of radial Herz–Schur multipliers on free groups. We prove that a generator of such a semigroup is linearly bounded by the word length function (see Theorem 1.6)....

  10. Composite Field Multiplier based on Look-Up Table for Elliptic Curve Cryptography Implementation

    Directory of Open Access Journals (Sweden)

    Marisa W. Paryasto

    2013-09-01

    Full Text Available Implementing a secure cryptosystem requires operations involving hundreds of bits. One of the most recommended algorithm is Elliptic Curve Cryptography (ECC. The complexity of elliptic curve algorithms and parameters with hundreds of bits requires specific design and implementation strategy. The design architecture must be customized according to security requirement, available resources and parameter choices. In this work we propose the use of composite field to implement finite field multiplication for ECC implementation. We use 299-bit keylength represented in GF((21323 instead of in GF(2299. Composite field multiplier can be implemented using different multiplier for ground-field and for extension field. In this paper, LUT is used for multiplication in the ground-field and classic multiplieris used for the extension field multiplication. A generic architecture for the multiplier is presented. Implementation is done with VHDL with the target device Altera DE2. The work in this paper uses the simplest algorithm to confirm the idea that by dividing field into composite, use different multiplier for base and extension field would give better trade-off for time and area. This work will be the beginning of our more advanced further research that implements composite-field using Mastrovito Hybrid, KOA and LUT.

  11. Composite Field Multiplier based on Look-Up Table for Elliptic Curve Cryptography Implementation

    Directory of Open Access Journals (Sweden)

    Marisa W. Paryasto

    2012-04-01

    Full Text Available Implementing a secure cryptosystem requires operations involving hundreds of bits. One of the most recommended algorithm is Elliptic Curve Cryptography (ECC. The complexity of elliptic curve algorithms and parameters with hundreds of bits requires specific design and implementation strategy. The design architecture must be customized according to security requirement, available resources and parameter choices. In this work we propose the use of composite field to implement finite field multiplication for ECC implementation. We use 299-bit keylength represented in GF((21323 instead of in GF(2299. Composite field multiplier can be implemented using different multiplier for ground-field and for extension field. In this paper, LUT is used for multiplication in the ground-field and classic multiplieris used for the extension field multiplication. A generic architecture for the multiplier is presented. Implementation is done with VHDL with the target device Altera DE2. The work in this paper uses the simplest algorithm to confirm the idea that by dividing field into composite, use different multiplier for base and extension field would give better trade-off for time and area. This work will be the beginning of our more advanced further research that implements composite-field using Mastrovito Hybrid, KOA and LUT.

  12. New Lagrange Multipliers for the Blind Adaptive Deconvolution Problem Applicable for the Noisy Case

    Directory of Open Access Journals (Sweden)

    Monika Pinchas

    2016-02-01

    Full Text Available Recently, a new blind adaptive deconvolution algorithm was proposed based on a new closed-form approximated expression for the conditional expectation (the expectation of the source input given the equalized or deconvolutional output where the output and input probability density function (pdf of the deconvolutional process were approximated with the maximum entropy density approximation technique. The Lagrange multipliers for the output pdf were set to those used for the input pdf. Although this new blind adaptive deconvolution method has been shown to have improved equalization performance compared to the maximum entropy blind adaptive deconvolution algorithm recently proposed by the same author, it is not applicable for the very noisy case. In this paper, we derive new Lagrange multipliers for the output and input pdfs, where the Lagrange multipliers related to the output pdf are a function of the channel noise power. Simulation results indicate that the newly obtained blind adaptive deconvolution algorithm using these new Lagrange multipliers is robust to signal-to-noise ratios (SNR, unlike the previously proposed method, and is applicable for the whole range of SNR down to 7 dB. In addition, we also obtain new closed-form approximated expressions for the conditional expectation and mean square error (MSE.

  13. Fourier Multiplier Theorems Involving Type and Cotype

    NARCIS (Netherlands)

    Rozendaal, J.; Veraar, M.C.

    2017-01-01

    In this paper we develop the theory of Fourier multiplier operators (Formula presented.), for Banach spaces X and Y, (Formula presented.) and (Formula presented.) an operator-valued symbol. The case (Formula presented.) has been studied extensively since the 1980s, but far less is known for

  14. TWOBODY - IMPROVED IMPLEMENTATION OF LAGRANGE MULTIPLIER

    Science.gov (United States)

    Watts, G. L.

    1994-01-01

    The Lagrange multiplier method has been used for many years by engineers to develop equations of motion in multibody problems. Use of the Lagrange multiplier has an advantage over some other formulations in that it preserves the original simple form of the equations of motion for each body. However, in typical time-varying dynamics simulations that use the Lagrange multiplier, computational instability can occur because integration error causes the two (or more) attached bodies to drift apart and violate the constraints. The computational instability usually happens suddenly, and the computed values "blow up" within a few time steps. TWOBODY utilizes a new programming technique which eliminates computational instability in multibody simulations that use the Lagrange multiplier. This new technique uses the constraint equations, instead of integration, to determine the coordinates that are not independent. TWOBODY employs a simple model, consisting of a solid rocket booster and a parachute connected by a frictionless swivel, to illustrate the new technique. TWOBODY is written in FORTRAN 77 for IBM PC series and compatible computers running MS-DOS. It requires 100K of RAM for execution. A sample executable is included with the distribution media. The standard distribution medium for this program is one 5.25 inch 360K MS-DOS format diskette. The program was developed on a 486/D33 workstation with lpi FORTRAN in 1992.

  15. Comparison of two automated instruments for Epstein-Barr virus serology in a large adult hospital and implementation of an Epstein-Barr virus nuclear antigen-based testing algorithm.

    Science.gov (United States)

    Al Sidairi, Hilal; Binkhamis, Khalifa; Jackson, Colleen; Roberts, Catherine; Heinstein, Charles; MacDonald, Jimmy; Needle, Robert; Hatchette, Todd F; LeBlanc, Jason J

    2017-11-01

    Serology remains the mainstay for diagnosis of Epstein-Barr virus (EBV) infection. This study compared two automated platforms (BioPlex 2200 and Architect i2000SR) to test three EBV serological markers: viral capsid antigen (VCA) immunoglobulins of class M (IgM), VCA immunoglobulins of class G (IgG) and EBV nuclear antigen-1 (EBNA-1) IgG. Using sera from 65 patients at various stages of EBV disease, BioPlex demonstrated near-perfect agreement for all EBV markers compared to a consensus reference. The agreement for Architect was near-perfect for VCA IgG and EBNA-1 IgG, and substantial for VCA IgM despite five equivocal results. Since the majority of testing in our hospital was from adults with EBNA-1 IgG positive results, post-implementation analysis of an EBNA-based algorithm showed advantages over parallel testing of the three serologic markers. This small verification demonstrated that both automated systems for EBV serology had good performance for all EBV markers, and an EBNA-based testing algorithm is ideal for an adult hospital.

  16. Input-constrained model predictive control via the alternating direction method of multipliers

    DEFF Research Database (Denmark)

    Sokoler, Leo Emil; Frison, Gianluca; Andersen, Martin S.

    2014-01-01

    is quadratic in the dimensions of the controlled system, and linear in the length of the prediction horizon. Simulations show that the approach proposed in this paper is more than an order of magnitude faster than several state-of-the-art quadratic programming algorithms, and that the difference in computation......This paper presents an algorithm, based on the alternating direction method of multipliers, for the convex optimal control problem arising in input-constrained model predictive control. We develop an efficient implementation of the algorithm for the extended linear quadratic control problem (LQCP...

  17. Tourism multipliers in the Mexican economy

    Directory of Open Access Journals (Sweden)

    Antonio Kido-Cruz

    2016-12-01

    Full Text Available This paper presents an analysis of the multiplier impact generated by the tourism sector in Mexico in the year 2013. The importance of studying this sector, in particular, lies in its contribution to the National GDP of over 8% and in its promising development based on services’ quality and the preferred destination of the developed countries. In addition, it is proposed to simulate the multiplier impact that will generate two current events, as they are, the construction of the new International Airport of Mexico and the increase of the investment in Fibers. The results were very punctual, a better distribution of the investment is generated, it is invested in the tourism sector, mainly in variables such as value added and remuneration.

  18. The power of fiscal multipliers in Croatia

    Directory of Open Access Journals (Sweden)

    Ana Grdović Gnip

    2014-06-01

    Full Text Available This paper investigates fiscal multipliers in Croatia in the period 1996Q1-2011Q4. For this purpose, a Blanchard Perotti three variable baseline SVAR is employed as a no regime-switch model, along with a four variable baseline STVAR as a regime-switch model. Results show that during recessions fiscal multipliers in Croatia tend to be much larger and move in line with Keynesian assumptions, i.e. a positive government spending shock increases output, private consumption and private investment, while oppositely a positive tax shock worsens the same macroeconomic variables. Moreover, during recession times government spending for purchases of goods and services seems to be the most effective fiscal instrument for boosting economic activity.

  19. Yeast peroxisomes multiply by growth and division

    OpenAIRE

    Motley, Alison M.; Hettema, Ewald H.

    2007-01-01

    Peroxisomes can arise de novo from the endoplasmic reticulum (ER) via a maturation process. Peroxisomes can also multiply by fission. We have investigated how these modes of multiplication contribute to peroxisome numbers in Saccharomyces cerevisiae and the role of the dynamin-related proteins (Drps) in these processes. We have developed pulse-chase and mating assays to follow the fate of existing peroxisomes, de novo–formed peroxisomes, and ER-derived preperoxisomal structures. We find that ...

  20. Multiplier-free filters for wideband SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Christensen, Erik Lintz

    2001-01-01

    This paper derives a set of parameters to be optimized when designing filters for digital demodulation and range prefiltering in SAR systems. Aiming at an implementation in field programmable gate arrays (FPGAs), an approach for the design of multiplier-free filters is outlined. Design results ar...... are presented in terms of filter complexity and performance. One filter has been coded in VHDL and preliminary results indicate that the filter can meet a 2 GHz input sample rate....

  1. The Uncertainty Multiplier and Business Cycles

    OpenAIRE

    Saijo, Hikaru

    2013-01-01

    I study a business cycle model where agents learn about the state of the economy by accumulating capital. During recessions, agents invest less, and this generates noisier estimates of macroeconomic conditions and an increase in uncertainty. The endogenous increase in aggregate uncertainty further reduces economic activity, which in turn leads to more uncertainty, and so on. Thus, through changes in uncertainty, learning gives rise to a multiplier effect that amplifies business cycles. I use ...

  2. Lagrange multiplier formalism for spin-2 fields

    International Nuclear Information System (INIS)

    Joseph, K.B.; Sabir, M.

    1980-01-01

    The Lagrange multiplier method is applied to the description of a spin-2 field. The method bypasses the problem of constraint breakdown and inconsistency of quantisation in the presence of interactions and the theory is shown to remain causal when coupled to an external electromagnetic field. Canonical quantisation of the field is carried out and a covariant propagator obtained. The massless limit of the theory is also discussed. (author)

  3. Mining, regional Australia and the economic multiplier

    Directory of Open Access Journals (Sweden)

    Paul Cleary

    2012-12-01

    Full Text Available Mining in Australia has traditionally delivered a strong development multiplier for regional communities where most mines are based. This relationship has weakened in recent decades as a result of the introduction of mobile workforces - typically known as fly in, fly out. Political parties have responded with policies known as ‘royalties for regions’, though in designing them they overlooked long established Indigenous arrangements for sharing benefits with areas affected directly by mining.

  4. Optimization algorithms and applications

    CERN Document Server

    Arora, Rajesh Kumar

    2015-01-01

    Choose the Correct Solution Method for Your Optimization ProblemOptimization: Algorithms and Applications presents a variety of solution techniques for optimization problems, emphasizing concepts rather than rigorous mathematical details and proofs. The book covers both gradient and stochastic methods as solution techniques for unconstrained and constrained optimization problems. It discusses the conjugate gradient method, Broyden-Fletcher-Goldfarb-Shanno algorithm, Powell method, penalty function, augmented Lagrange multiplier method, sequential quadratic programming, method of feasible direc

  5. Analysis of HLA-A24-restricted peptides of carcinoembryonic antigen using a novel structure-based peptide-HLA docking algorithm.

    Science.gov (United States)

    Nakamura, Yoji; Tai, Sachiko; Oshita, Chie; Iizuka, Akira; Ashizawa, Tadashi; Saito, Shuji; Yamaguchi, Shigeki; Kondo, Haruhiko; Yamaguchi, Ken; Akiyama, Yasuto

    2011-04-01

    Carcinoembryonic antigen (CEA) is a very common tumor marker because many types of solid cancer usually produce a variety of CEA and a highly sensitive measuring kit has been developed. However, immunological responses associated with CEA have not been fully characterized, and specifically a weak immunogenicity of CEA protein as a tumor antigen is reported in human leukocyte antigen (HLA)-A24-restricted CEA peptide-based cancer immunotherapy. These observations demonstrated that immunogenic and potent HLA-A24-restricted CTL epitope peptides derived from CEA protein are seemingly difficult to predict using a conventional bioinformatics approach based on primary amino acid sequence. In the present study, we developed an in silico docking simulation assay system of binding affinity between HLA-A24 protein and A24-restricted peptides using two software packages, AutoDock and MODELLER, and a crystal structure of HLA-A24 protein obtained from the Protein Data Bank. We compared the current assay system with HLA-peptide binding predictions of the bioinformatics and molecular analysis section (BIMAS) in terms of the prediction capability using MHC stabilization and peptide-stimulated CTL induction assays for CEA and other HLA-A24 peptides. The MHC stabilization score was inversely correlated with the affinity calculated in the docking simulation alone (r = -0.589, P = 0.015), not with BIMAS score or the IFN-γ production index. On the other hand, BIMAS was not significantly correlated with any other parameters. These results suggested that our in silico assay system has potential advantages in efficiency of epitope prediction over BIMAS and ease of use for bioinformaticians. © 2011 Japanese Cancer Association.

  6. Automobile Industry Retail Price Equivalent and Indirect Cost Multipliers

    Science.gov (United States)

    This report develops a modified multiplier, referred to as an indirect cost (IC) multiplier, which specifically evaluates the components of indirect costs that are likely to be affected by vehicle modifications associated with environmental regulation. A range of IC multipliers a...

  7. Study of heterogeneous multiplying and non-multiplying media by the neutron pulsed source technique

    International Nuclear Information System (INIS)

    Deniz, V.

    1969-01-01

    The pulsed neutron technique consists essentially in sending in the medium to be studied a short neutron pulse and in determining the asymptotic decay constant of the generated population. The variation of the decay constant as a function of the size of the medium allows the medium characteristics to be defined. This technique has been largely developed these last years and has been applied as well to moderator as to multiplying media, in most cases homogeneous ones. We considered of interest of apply this technique to lattices, to see if useful informations could be collected for lattice calculations. We present here a general theoretical study of the problem, and results and interpretation of a series of experiments made on graphite lattices. There is a good agreement for non-multiplying media. In the case of multiplying media, it is shown that the age value used until now in graphite lattices calculations is over-estimated by about 10 per cent [fr

  8. Eigenspace-Based Minimum Variance Adaptive Beamformer Combined with Delay Multiply and Sum: Experimental Study

    OpenAIRE

    Mozaffarzadeh, Moein; Mahloojifar, Ali; Nasiriavanaki, Mohammadreza; Orooji, Mahdi

    2017-01-01

    Delay and sum (DAS) is the most common beamforming algorithm in linear-array photoacoustic imaging (PAI) as a result of its simple implementation. However, it leads to a low resolution and high sidelobes. Delay multiply and sum (DMAS) was used to address the incapabilities of DAS, providing a higher image quality. However, the resolution improvement is not well enough compared to eigenspace-based minimum variance (EIBMV). In this paper, the EIBMV beamformer has been combined with DMAS algebra...

  9. 16QAM Blind Equalization via Maximum Entropy Density Approximation Technique and Nonlinear Lagrange Multipliers

    OpenAIRE

    Mauda, R.; Pinchas, M.

    2014-01-01

    Recently a new blind equalization method was proposed for the 16QAM constellation input inspired by the maximum entropy density approximation technique with improved equalization performance compared to the maximum entropy approach, Godard’s algorithm, and others. In addition, an approximated expression for the minimum mean square error (MSE) was obtained. The idea was to find those Lagrange multipliers that bring the approximated MSE to minimum. Since the derivation of the obtained MSE with ...

  10. Transient phenomena in bounded fast multiplying assemblies

    International Nuclear Information System (INIS)

    Kraft, T.E.

    1976-01-01

    A generalized dispersion formalism is developed in the context of time-, space-, and energy-dependent transport theory. The evolution of the neutron population in a fast multiplying system following an initial burst of neutrons is examined. The generalized dispersion law obtained is an integral equation, in one variable, for the Laplace and Fourier transformed time- and space-dependent sources of fission neutrons. An approximation technique is shown to generate solutions which converge in L 2 norm to the exact solution for exact elastic, exact inelastic, Goertzel-Grueling or Wigner scattering kernels, and any reasonable fission spectrum

  11. Modeling Photo-multiplier Gain and Regenerating Pulse Height Data for Application Development

    Science.gov (United States)

    Aspinall, Michael D.; Jones, Ashley R.

    2018-01-01

    Systems that adopt organic scintillation detector arrays often require a calibration process prior to the intended measurement campaign to correct for significant performance variances between detectors within the array. These differences exist because of low tolerances associated with photo-multiplier tube technology and environmental influences. Differences in detector response can be corrected for by adjusting the supplied photo-multiplier tube voltage to control its gain and the effect that this has on the pulse height spectra from a gamma-only calibration source with a defined photo-peak. Automated methods that analyze these spectra and adjust the photo-multiplier tube bias accordingly are emerging for hardware that integrate acquisition electronics and high voltage control. However, development of such algorithms require access to the hardware, multiple detectors and calibration source for prolonged periods, all with associated constraints and risks. In this work, we report on a software function and related models developed to rescale and regenerate pulse height data acquired from a single scintillation detector. Such a function could be used to generate significant and varied pulse height data that can be used to integration-test algorithms that are capable of automatically response matching multiple detectors using pulse height spectra analysis. Furthermore, a function of this sort removes the dependence on multiple detectors, digital analyzers and calibration source. Results show a good match between the real and regenerated pulse height data. The function has also been used successfully to develop auto-calibration algorithms.

  12. Rhinoplasty for the multiply revised nose.

    Science.gov (United States)

    Foda, Hossam M T

    2005-01-01

    To evaluate the problems encountered on revising a multiply operated nose and the methods used in correcting such problems. The study included 50 cases presenting for revision rhinoplasty after having had 2 or more previous rhinoplasties. An external rhinoplasty approach was used in all cases. Simultaneous septal surgery was done whenever indicated. All cases were followed for a mean period of 32 months (range, 1.5-8 years). Evaluation of the surgical result depended on clinical examination, comparison of pre- and postoperative photographs, and degree of patients' satisfaction with their aesthetic and functional outcome. Functionally, 68% suffered nasal obstruction that was mainly caused by septal deviations and nasal valve problems. Aesthetically, the most common deformities of the upper two thirds of the nose included pollybeak (64%), dorsal irregularities (54%), dorsal saddle (44%), and open roof deformity (42%), whereas the deformities of lower third included depressed tip (68%), tip contour irregularities (60%), and overrotated tip (42%). Nasal grafting was necessary in all cases; usually more than 1 type of graft was used in each case. Postoperatively, 79% of the patients, with preoperative nasal obstruction, reported improved breathing; 84% were satisfied with their aesthetic result; and only 8 cases (16%) requested further revision to correct minor deformities. Revision of a multiply operated nose is a complex and technically demanding task, yet, in a good percentage of cases, aesthetic as well as functional improvement are still possible.

  13. Quantum mechanics in a multiply connected region

    International Nuclear Information System (INIS)

    Miyazawa, H.

    1986-01-01

    It is usually assumed that wave fields or wave functions are single valued functions of space-time. However, the phase of a complex field is an unobservable quantity and there is no obvious reason that it must be single valued. On this point quantum mechanics in a multiply connected regions is not well formulated. This ambiguity appears e.g., in the case of the Bohm-Aharonov effect concerning the observability of the vector potential around a magnetic flux. The author discusses the single or multiple valuedness of wave functions and attempts to see if such an effect really exists or not. The wave function of a charged particle in a multiply connected region is not necessarily single valued. The condition that the ground state energy be a minimum fixes the character of the multiple valuedness. For a charged particle around a magnetic flux a multiple valued wave function is preferable and no Bohm-Aharonov effect is observed. The minimum energy principle is proved if one also considers the interaction of a charged particle with external objects. Then theoretically the Bohm-Aharonov effect should not be observed. Experiments are not yet conclusive on this point

  14. Tritium-caused background currents in electron multipliers

    International Nuclear Information System (INIS)

    Malinowski, M.E.

    1979-05-01

    One channel electron multiplier (Galileo No. 4501) and one 14 stage Be/Cu multiplier (Dumont No. SPM3) were exposed to tritium pressures between approx. 10 -7 Torr to 10 -3 Torr in amounts from approx. 10 -5 Torr-s to 60 Torr-s and the β-decay caused currents in the multipliers measured. The background currents in both multipliers consisted of two components: (1) a high, reversible current which was proportional to the tritium exposure pressure; and (2) a lower, irreversible background current which increased with increasing cumulative tritium exposure. The β-decay caused currents in each multiplier increased the same way with exposure, suggesting the detected electrons arose from decaying tritium adsorbed on surfaced external to the multipliers

  15. Hadamard Multipliers and Abel Dual of Hardy Spaces

    Directory of Open Access Journals (Sweden)

    Paweł Mleczko

    2016-01-01

    Full Text Available The paper is devoted to the study of Hadamard multipliers of functions from the abstract Hardy classes generated by rearrangement invariant spaces. In particular the relation between the existence of such multiplier and the boundedness of the appropriate convolution operator on spaces of measurable functions is presented. As an application, the description of Hadamard multipliers into H∞ is given and the Abel type theorem for mentioned Hardy spaces is proved.

  16. Multipliers on weighted Hardy spaces over certain totally disconnected groups

    Directory of Open Access Journals (Sweden)

    Toshiyuki Kitada

    1988-01-01

    Full Text Available In this note, we consider the multipliers on weighted H1 spaces over totally disconnected locally compact abelian groups with a suitable sequence of open compact subgroups (Vilenkin groups. We first show an (H1,L1 multiplier result from which Onneweer's theorem follows. We also give an (H1,H1 multiplier result under a condition of Baernstein-Sawyer type.

  17. Metrology and Transport of Multiply Charged Ions

    Science.gov (United States)

    Kulkarni, Dhruva

    The transport and interaction of singly- and multiply-charged ions with matter has been studied. The experiments were performed in an ultra-high vacuum environment. The low- and hyperthermal-energy ion beamline was used as a source of singly charged ions, while the CUEBIT facility was used as a source of multiply charged ions. The kinetic energy of the ion beam obtained from the CUEBIT is offset from the nominal value expected from the applied electrostatic potentials. These offsets were studied by measuring the kinetic energy of the beam using a retarding field analyzer (RFA). The offset was attributed to the space charge of the electron beam that is used to create the multiply charged ions. The charge density of the electron beam was varied by changing operational parameters of the electron beam, namely the electron beam current and the energy of the electron beam. Ion beams of Ar4+ and Ar8+ were extracted from the source and the offsets observed in the kinetic energy were related to the variation in the space charge potential of the electron beam. Measurements of these offsets, ranging from 100 eV/Q to 300 eV/Q, are significant and important for experiments that aim to utilize the potential energy of slow multiply charged ions. The transport of ions using capillaries has been studied to investigate the viability of ion-guiding as a means for a novel ion delivery mechanism. Results on transport through large bore capillaries (macrocapillaries) that probe both the geometric and ionguided mechanisms are presented. The angle- and position-dependent transport properties were found to depend on the material of the capillary (specifically, whether metal or insulator) and the geometry of the capillary. Rb+ ions at a kinetic energy of 1 keV were transmitted through metal and glass capillaries that were a few centimeters in length and a few millimeters in diameter. Oscillations were observed in the capillaries made of glass which were absent in the metal capillaries

  18. Four-gate transistor analog multiplier circuit

    Science.gov (United States)

    Mojarradi, Mohammad M. (Inventor); Blalock, Benjamin (Inventor); Cristoloveanu, Sorin (Inventor); Chen, Suheng (Inventor); Akarvardar, Kerem (Inventor)

    2011-01-01

    A differential output analog multiplier circuit utilizing four G.sup.4-FETs, each source connected to a current source. The four G.sup.4-FETs may be grouped into two pairs of two G.sup.4-FETs each, where one pair has its drains connected to a load, and the other par has its drains connected to another load. The differential output voltage is taken at the two loads. In one embodiment, for each G.sup.4-FET, the first and second junction gates are each connected together, where a first input voltage is applied to the front gates of each pair, and a second input voltage is applied to the first junction gates of each pair. Other embodiments are described and claimed.

  19. Electronic de-multipliers; Demultiplicateurs electroniques

    Energy Technology Data Exchange (ETDEWEB)

    Ailloud, J

    1948-07-01

    The counting of a huge number of events, randomly or periodically distributed, requires the use of electronic counters which can work with a flow of up to 500000 events per second, while mechanical systems have a much lower resolution which leads to an important percentage of losses (non-counted events). Thus, hybrid systems are generally used which comprise an electronic part with fast counting capabilities but low recording capacities, and a mechanical part for the recording of the successive resets of the electronic part. This report describes the basic elementary circuits of these electronic counters (de-multipliers): dividers by 2 and 5 and flip-flop circuits using triode and pentode valves for the counting of events in the decimal system. (J.S.)

  20. Fabrication and measurement of gas electron multiplier

    International Nuclear Information System (INIS)

    Zhang Minglong; Xia Yiben; Wang Linjun; Gu Beibei; Wang Lin; Yang Ying

    2005-01-01

    Gas electron multiplier (GEM) with special performance has been widely used in the field of radiation detectors. In this work, GEM film was fabricated using a 50 μm -thick kapton film by the therma evaporation and laser masking drilling technique. GEM film has many uniformly arrayed holes with a diameter of 100 μm and a gap of 223 μm. It was then set up to a gas-flowing detector with an effective area of 3 x 3 cm 2 , 5.9 keV X-ray generated from a 55 Fe source was used to measure the pulse height distribution of GEM operating at various high voltage and gas proportion. The effect of high potential and gas proportion on the count rate and the energy resolution was discussed in detail. The results indicate that GEM has a very high ratio of signal to noise and better energy resolution of 18.2%. (authors)

  1. Efek Multiplier Zakat terhadap Pendapatan di Provinsi DKI Jakarta

    OpenAIRE

    Al Arif, M. Nur Rianto

    2012-01-01

    The aim of this research is to analyse the multiplier effect of zakâh revenue in DKI Jakarta. A study case at Badan Amil Zakat, Infak, and Sadaqah (BAZIS) DKI Jakarta. Least square method is used to analyze the data. The coefficients will be used to calculate the multiplier effect of zakâh-revenue and it will be compared with the economy without zakah revenue. The results showed 2,522 multiplier effects of zakâh-revenue and 3.561 multiplier effect ofeconomic income without zakâh-revenue. Thi...

  2. Dimension of the c-nilpotent multiplier of Lie algebras

    Indian Academy of Sciences (India)

    By a Lie algebra we mean a vector space over a field F with the Lie bracket [ , ]. The finite dimensional Lie algebra analogous to the Schur multiplier was developed in. [4, 5] and has been studied by various authors [7, 8, 14]. Let L be a finite dimensional. Lie algebra, its Schur multiplier, M(L), can be defined as a second ...

  3. Multipliers for the Absolute Euler Summability of Fourier Series

    Indian Academy of Sciences (India)

    In this paper, the author has investigated necessary and sufficient conditions for the absolute Euler summability of the Fourier series with multipliers. These conditions are weaker than those obtained earlier by some workers. It is further shown that the multipliers are best possible in certain sense.

  4. Multiplier convergent series and uniform convergence of mapping ...

    Indian Academy of Sciences (India)

    MS received 14 April 2011; revised 17 November 2012. Abstract. In this paper, we introduce the frame property of complex sequence sets and study the uniform convergence of nonlinear mapping series in β-dual of spaces consisting of multiplier convergent series. Keywords. Multiplier convergent series; mapping series. 1.

  5. Dimension of the c-nilpotent multiplier of Lie algebras

    Indian Academy of Sciences (India)

    Abstract. The purpose of this paper is to derive some inequalities for dimension of the c-nilpotent multiplier of finite dimensional Lie algebras and their factor Lie algebras. We further obtain an inequality between dimensions of c-nilpotent multiplier of Lie algebra L and tensor product of a central ideal by its abelianized factor ...

  6. An algebra of absolutely continuous functions and its multipliers

    Indian Academy of Sciences (India)

    Introduction. Let I = [0, 1] be the compact topological semigroup with max multiplication and usual topology. C(I),Lp(I), 1 ≤ p ≤ ∞ are the associated Banach algebras. Larsen [5] obtained multipliers for the Banach algebra L1(I). Baker, Pym and Vasudeva [1] obtain characterizations of multipliers from Lp(I) to Lr(I), 1 ≤ r, ...

  7. Negative probability of random multiplier in turbulence

    Science.gov (United States)

    Bai, Xuan; Su, Weidong

    2017-11-01

    The random multiplicative process (RMP), which has been proposed for over 50 years, is a convenient phenomenological ansatz of turbulence cascade. In the RMP, the fluctuation in a large scale is statistically mapped to the one in a small scale by the linear action of an independent random multiplier (RM). Simple as it is, the RMP is powerful enough since all of the known scaling laws can be included in this model. So far as we know, however, a direct extraction for the probability density function (PDF) of RM has been absent yet. The reason is the deconvolution during the process is ill-posed. Nevertheless, with the progress in the studies of inverse problems, the situation can be changed. By using some new regularization techniques, for the first time we recover the PDFs of the RMs in some turbulent flows. All the consistent results from various methods point to an amazing observation-the PDFs can attain negative values in some intervals; and this can also be justified by some properties of infinitely divisible distributions. Despite the conceptual unconventionality, the present study illustrates the implications of negative probability in turbulence in several aspects, with emphasis on its role in describing the interaction between fluctuations at different scales. This work is supported by the NSFC (No. 11221062 and No. 11521091).

  8. Content Adaptive Lagrange Multiplier Selection for Rate-Distortion Optimization in 3-D Wavelet-Based Scalable Video Coding

    Directory of Open Access Journals (Sweden)

    Ying Chen

    2018-03-01

    Full Text Available Rate-distortion optimization (RDO plays an essential role in substantially enhancing the coding efficiency. Currently, rate-distortion optimized mode decision is widely used in scalable video coding (SVC. Among all the possible coding modes, it aims to select the one which has the best trade-off between bitrate and compression distortion. Specifically, this tradeoff is tuned through the choice of the Lagrange multiplier. Despite the prevalence of conventional method for Lagrange multiplier selection in hybrid video coding, the underlying formulation is not applicable to 3-D wavelet-based SVC where the explicit values of the quantization step are not available, with on consideration of the content features of input signal. In this paper, an efficient content adaptive Lagrange multiplier selection algorithm is proposed in the context of RDO for 3-D wavelet-based SVC targeting quality scalability. Our contributions are two-fold. First, we introduce a novel weighting method, which takes account of the mutual information, gradient per pixel, and texture homogeneity to measure the temporal subband characteristics after applying the motion-compensated temporal filtering (MCTF technique. Second, based on the proposed subband weighting factor model, we derive the optimal Lagrange multiplier. Experimental results demonstrate that the proposed algorithm enables more satisfactory video quality with negligible additional computational complexity.

  9. A Lagrange multiplier and Hopfield-type barrier function method for the traveling salesman problem.

    Science.gov (United States)

    Dang, Chuangyin; Xu, Lei

    2002-02-01

    A Lagrange multiplier and Hopfield-type barrier function method is proposed for approximating a solution of the traveling salesman problem. The method is derived from applications of Lagrange multipliers and a Hopfield-type barrier function and attempts to produce a solution of high quality by generating a minimum point of a barrier problem for a sequence of descending values of the barrier parameter. For any given value of the barrier parameter, the method searches for a minimum point of the barrier problem in a feasible descent direction, which has a desired property that lower and upper bounds on variables are always satisfied automatically if the step length is a number between zero and one. At each iteration, the feasible descent direction is found by updating Lagrange multipliers with a globally convergent iterative procedure. For any given value of the barrier parameter, the method converges to a stationary point of the barrier problem without any condition on the objective function. Theoretical and numerical results show that the method seems more effective and efficient than the softassign algorithm.

  10. A Lagrange multiplier mixed finite element formulation for three-dimensional contact of biphasic tissues.

    Science.gov (United States)

    Yang, Taiseung; Spilker, Robert L

    2007-06-01

    A three-dimensional (3D) contact finite element formulation has been developed for biological soft tissue-to-tissue contact analysis. The linear biphasic theory of Mow, Holmes, and Lai (1984, J. Biomech., 17(5), pp. 377-394) based on continuum mixture theory, is adopted to describe the hydrated soft tissue as a continuum of solid and fluid phases. Four contact continuity conditions derived for biphasic mixtures by Hou et al. (1989, ASME J. Biomech. Eng., 111(1), pp. 78-87) are introduced on the assumed contact surface, and a weighted residual method has been used to derive a mixed velocity-pressure finite element contact formulation. The Lagrange multiplier method is used to enforce two of the four contact continuity conditions, while the other two conditions are introduced directly into the weighted residual statement. Alternate formulations are possible, which differ in the choice of continuity conditions that are enforced with Lagrange multipliers. Primary attention is focused on a formulation that enforces the normal solid traction and relative fluid flow continuity conditions on the contact surface using Lagrange multipliers. An alternate approach, in which the multipliers enforce normal solid traction and pressure continuity conditions, is also discussed. The contact nonlinearity is treated with an iterative algorithm, where the assumed area is either extended or reduced based on the validity of the solution relative to contact conditions. The resulting first-order system of equations is solved in time using the generalized finite difference scheme. The formulation is validated by a series of increasingly complex canonical problems, including the confined and unconfined compression, the Hertz contact problem, and two biphasic indentation tests. As a clinical demonstration of the capability of the contact analysis, the gleno-humeral joint contact of human shoulders is analyzed using an idealized 3D geometry. In the joint, both glenoid and humeral head

  11. Sociophysics of sexism: normal and anomalous petrie multipliers

    Science.gov (United States)

    Eliazar, Iddo

    2015-07-01

    A recent mathematical model by Karen Petrie explains how sexism towards women can arise in organizations where male and female are equally sexist. Indeed, the Petrie model predicts that such sexism will emerge whenever there is a male majority, and quantifies this majority bias by the ‘Petrie multiplier’: the square of the male/female ratio. In this paper—emulating the shift from ‘normal’ to ‘anomalous’ diffusion—we generalize the Petrie model to a stochastic Poisson model that accommodates heterogeneously sexist men and woman, and that extends the ‘normal’ quadratic Petrie multiplier to ‘anomalous’ non-quadratic multipliers. The Petrie multipliers span a full spectrum of behaviors which we classify into four universal types. A variation of the stochastic Poisson model and its Petrie multipliers is further applied to the context of cyber warfare.

  12. Atomic collisions in fusion plasmas involving multiply charged ions

    International Nuclear Information System (INIS)

    Salzborn, E.

    1980-01-01

    A short survey is given on atomic collisions involving multiply charged ions. The basic features of charge transfer processes in ion-ion and ion-atom collisions relevant to fusion plasmas are discussed. (author)

  13. Isometric multipliers of a vector valued Beurling algebra on a ...

    Indian Academy of Sciences (India)

    s12044-016-0297-0. Isometric multipliers of a vector valued Beurling algebra on a discrete semigroup. PRAKASH A DABHI. ∗ and MANISH KUMAR PANDEY. Department of Mathematics, Sardar Patel University, Vallabh Vidyanagar. 388 120, India.

  14. Instructional Computing Project Uses "Multiplier Effect" to Train Florida Teachers.

    Science.gov (United States)

    Roblyer, M. D.; Castine, W. H.

    1987-01-01

    Reviews the efforts undertaken in the Florida Model Microcomputer Trainer Project (FMMTP) and its statewide impact. Outlines its procedural strategies, trainer curriculum, networking system, and the results of its multiplier effect. (ML)

  15. Evaporator line for special electron tubes, in particular electron multipliers

    International Nuclear Information System (INIS)

    Richter, M.

    1984-01-01

    The invention has been aimed at reducing the effort for preventing short circuits in achieving certain material-dependent effects e.g. secondary emission, by deposition through evaporation in the production of electron tubes, in particular electron multipliers

  16. EFEK MULTIPLIER ZAKAT TERHADAP PENDAPATAN DI PROVINSI DKI JAKARTA

    Directory of Open Access Journals (Sweden)

    M. Nur Rianto Al Arif

    2016-02-01

    Full Text Available The aim of this research is to analyse the multiplier effect of zakâh revenue in DKI Jakarta. A study case at Badan Amil Zakat, Infak, and Sadaqah (BAZIS DKI Jakarta. Least square method is used to analyze the data. The coefficients will be used to calculate the multiplier effect of zakâh-revenue and it will  be compared with the economy without zakah revenue. The results showed 2,522 multiplier effects of zakâh-revenue and 3.561 multiplier effect ofeconomic income without zakâh-revenue. This suggests that the management of zakat in BAZIS Jakarta still can have a significant influence on the economy.DOI: 10.15408/aiq.v4i1.2533

  17. Efek Multiplier Zakat Terhadap Pendapatan di Propinsi DKI Jakarta

    Directory of Open Access Journals (Sweden)

    M. Nur Rianto Al Arif

    2015-10-01

    Full Text Available The aim of this research is to analyze the multiplier effect of zakah revenue in DKI Jakarta, a study case at Badan Amil Zakat, Infak, and Shadaqah (BAZIS DKI Jakarta. Least square methods is used to analyze the data. The coefficient will be used to calculate the multiplier effect of zakah revenue and it will be compared with the economy without zakah revenue. The result showed 2,522 multiplier effects of zakah revenue and 3,561 multiplier effect of economic income without zakah revenue. This suggest that the management of zakah in BAZIS DKI Jakarta still can have a significant influence on the economyDOI: 10.15408/aiq.v4i1.2079

  18. Fallacy of the multiplier effect: Correcting the income analysis

    OpenAIRE

    Ono, Yoshiyasu

    2006-01-01

    Although the Keynesian multiplier effect of public works is criticized for lack of a microeconomic foundation, it is still taught in most undergraduate courses and believed to be useful for policy makers. However, it has a serious fallacy even if we accept the consumption function. This note shows that useless public works is equivalent to unemployment relief expenditure in the presence of unemployment and that the argument on the multiplier effect seriously misleads the present national acco...

  19. Isometric multipliers of a vector valued Beurling algebra on a ...

    Indian Academy of Sciences (India)

    Let ( S , ω ) be a weighted abelian semigroup, let M ω ( S ) be the semigroup of ω -bounded multipliers of S , and let A be a strictly convex commutative Banach algebra with identity. It is shown that T is an onto isometric multiplier of l 1 ( S , ω , A ) if and only if there exists an invertible σ ∈ M ω ( S ) , a unitary point a ∈ A , and ...

  20. The generalization of the Schur multipliers of Bieberbach groups

    Science.gov (United States)

    Masri, Rohaidah; Hassim, Hazzirah Izzati Mat; Sarmin, Nor Haniza; Ali, Nor Muhainiah Mohd; Idrus, Nor'ashiqin Mohd

    2014-12-01

    The Schur multiplier is the second homology group of a group. It has been found to be isomorphic to the kernel of a homomorphism which maps the elements in the exterior square of the group to the elements in its derived subgroup. Meanwhile, a Bieberbach group is a space group which is a discrete cocompact group of isometries of oriented Euclidean space. In this research, the Schur multipliers of Bieberbach groups with cyclic point group of order two of finite dimension are computed.

  1. Physics of subcritical multiplying regions and experimental validation

    International Nuclear Information System (INIS)

    Salvatores, M.

    1996-01-01

    The coupling of a particle accelerator with a spallation target and with a subcritical multiplying region has been proposed in the fifties and is called here a hybrid system. This article gives some ideas about the energetic balance of such a system. The possibilities of experimental validation of some properties of a subcritical multiplying region by using MASURCA facility at CEA-Cadarache are examined. The results of a preliminary experiment called MUSE are presented. (A.C.)

  2. Carcinoma-associated antigens

    International Nuclear Information System (INIS)

    Bartorelli, A.; Accinni, R.

    1981-01-01

    This invention relates to novel antigens associated with breast carcinoma, anti-sera specific to said antigens, 125 I-labeled forms of said antigens and methods of detecting said antigens in serum or plasma. The invention also relates to a diagnostic kit containing standardised antigens or antisera or marked forms thereof for the detection of said antigens in human blood, serum or plasma. (author)

  3. Compressed sensing MRI via fast linearized preconditioned alternating direction method of multipliers.

    Science.gov (United States)

    Chen, Shanshan; Du, Hongwei; Wu, Linna; Jin, Jiaquan; Qiu, Bensheng

    2017-04-27

    The challenge of reconstructing a sparse medical magnetic resonance image based on compressed sensing from undersampled k-space data has been investigated within recent years. As total variation (TV) performs well in preserving edge, one type of approach considers TV-regularization as a sparse structure to solve a convex optimization problem. Nevertheless, this convex optimization problem is both nonlinear and nonsmooth, and thus difficult to handle, especially for a large-scale problem. Therefore, it is essential to develop efficient algorithms to solve a very broad class of TV-regularized problems. In this paper, we propose an efficient algorithm referred to as the fast linearized preconditioned alternating direction method of multipliers (FLPADMM), to solve an augmented TV-regularized model that adds a quadratic term to enforce image smoothness. Because of the separable structure of this model, FLPADMM decomposes the convex problem into two subproblems. Each subproblem can be alternatively minimized by augmented Lagrangian function. Furthermore, a linearized strategy and multistep weighted scheme can be easily combined for more effective image recovery. The method of the present study showed improved accuracy and efficiency, in comparison to other methods. Furthermore, the experiments conducted on in vivo data showed that our algorithm achieved a higher signal-to-noise ratio (SNR), lower relative error (Rel.Err), and better structural similarity (SSIM) index in comparison to other state-of-the-art algorithms. Extensive experiments demonstrate that the proposed algorithm exhibits superior performance in accuracy and efficiency than conventional compressed sensing MRI algorithms.

  4. Real-Time Pricing for Demand Response in Smart Grid Based on Alternating Direction Method of Multipliers

    Directory of Open Access Journals (Sweden)

    Hongbo Zhu

    2018-01-01

    Full Text Available The real-time pricing (RTP scheme is an ideal method to adjust the power balance between supply and demand in smart grid systems. This scheme has a profound impact on users’ behavior, system operation, and overall grid management in the electricity industry. In this research, we conduct an extended discussion of a RTP optimization model and give a theoretical analysis of the existence and uniqueness of the Lagrangian multiplier. A distributed optimization method based on the alternating direction method of multipliers (ADMM algorithm with Gaussian back substitution (GBS is proposed in this study. On the one hand, the proposed algorithm takes abundant advantage of the separability among variables in the model. On the other hand, the proposed algorithm can not only speed up the convergence rate to enhance the efficiency of computing, but also overcome the deficiency of the distributed dual subgradient algorithm, the possibility of nonconvergence in the iteration process. In addition, we give the theoretical proof of the convergence of the proposed algorithm. Furthermore, the interdependent relationship between variables has been discussed in depth during numerical simulations in the study. Compared with the dual subgradient method, the simulation results validate that the proposed algorithm has a higher convergence speed and better implementation effect.

  5. ANTIGENIC PROMOTION

    Science.gov (United States)

    Wu, Chin-Yu; Cinader, Bernard

    1971-01-01

    Rabbits were immunized with p-azobenzene arsonic acid derivatives of human serum albumin (HA-As) or of dissociated keyhole limpet hemocyanin. The IgM response to the hapten was evaluated in terms of the number of hapten-specific plaque-forming cells in the lymph node draining the injection site. In some experiments, antibody was measured by agglutination of tanned and sensitized erythrocytes. The hapten response of animals immunized with HA-As was increased (promoting effect) when the animals were injected with one of several structurally unrelated macromolecules: keyhole limpet hemocyanin (KLH), horse spleen ferritin (HSF), lysozyme (Lys), alum-precipitated human gamma globulin (alum-precipitated HGG). Different macromolecules differed in the magnitude of the promoting effect they induced, e.g., promotion by the associated form of KLH was greater than that by the dissociated form; alum-precipitated HGG was a better promoter than was soluble HGG. The relative magnitude of promotion by different macromolecules (associated vs. dissociated KLH, alum-precipitated vs. soluble HGG) correlated with the relative magnitude of the carrier effect, as judged by the hapten response induced by p-azobenzene arsonic acid conjugated to various proteins. Promotion was detected by agglutination assay of circulating antibody, by plaque assay of cells from the popliteal lymph node draining the site of preinjection, but not by plaque assay of cells from the contralateral lymph node. Promotion was dependent on the dose of the promoting macromolecule and on the dose of the hapten-protein conjugate. It was not observed in animals tolerant to the promoting macromolecule. Inhibition (i.e. antigenic competition), rather than promotion, was observed upon a secondary response to the preinjected macromolecule or when the hapten-protein conjugate was incorporated in Freund's adjuvant. PMID:15776570

  6. Study on neutron irradiation behavior of beryllium as neutron multiplier

    Energy Technology Data Exchange (ETDEWEB)

    Ishitsuka, Etsuo [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    1998-03-01

    More than 300 tons beryllium is expected to be used as a neutron multiplier in ITER, and study on the neutron irradiation behavior of beryllium as the neutron multiplier with Japan Materials Testing Reactor (JMTR) were performed to get the engineering data for fusion blanket design. This study started as the study on the tritium behavior in beryllium neutron reflector in order to make clear the generation mechanism on tritium of JMTR primary coolant since 1985. These experiences were handed over to beryllium studies for fusion study, and overall studies such as production technology of beryllium pebbles, irradiation behavior evaluation and reprocessing technology have been started since 1990. In this presentation, study on the neutron irradiation behavior of beryllium as the neutron multiplier with JMTR was reviewed from the point of tritium release, thermal properties, mechanical properties and reprocessing technology. (author)

  7. Study on neutron irradiation behavior of beryllium as neutron multiplier

    International Nuclear Information System (INIS)

    Ishitsuka, Etsuo

    1998-01-01

    More than 300 tons beryllium is expected to be used as a neutron multiplier in ITER, and study on the neutron irradiation behavior of beryllium as the neutron multiplier with Japan Materials Testing Reactor (JMTR) were performed to get the engineering data for fusion blanket design. This study started as the study on the tritium behavior in beryllium neutron reflector in order to make clear the generation mechanism on tritium of JMTR primary coolant since 1985. These experiences were handed over to beryllium studies for fusion study, and overall studies such as production technology of beryllium pebbles, irradiation behavior evaluation and reprocessing technology have been started since 1990. In this presentation, study on the neutron irradiation behavior of beryllium as the neutron multiplier with JMTR was reviewed from the point of tritium release, thermal properties, mechanical properties and reprocessing technology. (author)

  8. Principal parameters of classical multiply charged ion sources

    International Nuclear Information System (INIS)

    Winter, H.; Wolf, B.H.

    1974-01-01

    A review is given of the operational principles of classical multiply charged ion sources (operating sources for intense beams of multiply charged ions using discharge plasmas; MCIS). The fractional rates of creation of multiply charged ions in MCIS plasmas cannot be deduced from the discharge parameters in a simple manner; they depend essentially on three principal parameters, the density and energy distribution of the ionizing electrons, and the confinement time of ions in the ionization space. Simple discharge models were used to find relations between principal parameters, and results of model calculations are compared to actually measured charge state density distributions of extracted ions. Details of processes which determine the energy distribution of ionizing electrons (heating effects), confinement times of ions (instabilities), and some technical aspects of classical MCIS (cathodes, surface processes, conditioning, life time) are discussed

  9. Scattering and absorption properties of multiply coated magnetic nanoparticles.

    Science.gov (United States)

    Puri, Shruti; Mukhopadhyay, Gautam

    2009-09-01

    The optical properties of a material are characterized by its electric and magnetic susceptibilities. Finding analytical expressions for those quantities for a nanoparticle of arbitrary shape is generally a formidable task. A great deal of insight in to the basic phenomena can be obtained by studying analytically solvable cases, for nanoparticles of ellipsoidal and spherical shapes. We present here our study on the scattering and absorptive properties of multiply coated magnetic spherical and elliptical nanoparticles as functions of frequency of an incident electromagnetic radiation. We will present our results based on the analytical expressions for the dielectric and magnetic susceptibilities derived for such multiply coated nanoparticles. To our knowledge, the latter results are new. We will also present our results based on Maxwell-Garnett theory for a material having uniform distribution of mono dispersed multiply coated nanoparticles.

  10. A Frequency Multiplier Based on Time Recursive Processing

    Directory of Open Access Journals (Sweden)

    D. M. Perisic

    2017-12-01

    Full Text Available This paper describes a digital frequency multiplier for a pulse rate. The multiplier is based on the recursive processing of the input and output periods and their time differences. Special emphasis is devoted to the techniques which provide the development of multipliers based on this principle. The circuit is defined by two system parameters. One is the ratio of two clock frequencies and the other is a division factor of a binary counter. The realization of the circuit is described. The region of the system parameters for the stable circuit is presented. The different aspects of applications and limitations in realization of the circuit are considered. All mathematical analyses are made using a Z transform approach. It is shown that the circuit can be also used in tracking and prediction applications. Computer simulations are performed to prove the correctness of the math and the whole approach.

  11. Multiplier Accounting of Indian Mining Industry: The Application

    Science.gov (United States)

    Hussain, Azhar; Karmakar, Netai Chandra

    2017-10-01

    In the previous paper (Hussain and Karmakar in Inst Eng India Ser, 2014. doi: 10.1007/s40033-014-0058-0), the concepts of input-output transaction matrix and multiplier were explained in detail. Input-output multipliers are indicators used for predicting the total impact on an economy due to changes in its industrial demand and output which is calculated using transaction matrix. The aim of this paper is to present an application of the concepts with respect to the mining industry, showing progress in different sectors of mining with time and explaining different outcomes from the results obtained. The analysis shows that a few mineral industries saw a significant growth in their multiplier values over the years.

  12. Radial multipliers on amalgamated free products of II-factors

    DEFF Research Database (Denmark)

    Möller, Sören

    2014-01-01

    Let ℳi be a family of II1-factors, containing a common II1-subfactor 풩, such that [ℳi : 풩] ∈ ℕ0 for all i. Furthermore, let ϕ: ℕ0 → ℂ. We show that if a Hankel matrix related to ϕ is trace-class, then there exists a unique completely bounded map Mϕ on the amalgamated free product of the ℳi with a...... with amalgamation over 풩, which acts as a radial multiplier. Hereby, we extend a result of Haagerup and the author for radial multipliers on reduced free products of unital C*- and von Neumann algebras....

  13. Morbidity of Early Spine Surgery in the Multiply Injured Patient

    Science.gov (United States)

    2014-07-31

    chest trauma 9 30 % Exploratory laparotomy 8 27 % Lactate [ 2.5 mEq/L 6 20 % Platelet \\110,000/mm3 4 13 % 10 U PRBCs pre-spine surgery 4 13 % ISS...ORTHOPAEDIC SURGERY Morbidity of early spine surgery in the multiply injured patient J. W. Galvin • B. A. Freedman • A. J. Schoenfeld • A. P. Cap • J... surgery for multiply injured patients with operative spinal injuries remains unknown. The purported benefits of early intervention must be weighed

  14. Spot Pricing When Lagrange Multipliers Are Not Unique

    DEFF Research Database (Denmark)

    Feng, Donghan; Xu, Zhao; Zhong, Jin

    2012-01-01

    Classical spot pricing theory is based on multipliers of the primal problem of an optimal market dispatch, i.e., the solution of the dual problem. However, the dual problem of market dispatch may yield multiple solutions. In these circumstances, spot pricing or any standard pricing practice based...... on multipliers cannot generate a unique clearing price. Although such situations are rare, they can cause significant uncertainties and complexities in market dispatch. In practice, this situation is solved through simple empirical methods, which may cause additional operations or biased allocation. Based...... the results of the theoretical analysis, and further demonstrate that the method performs effectively in both uniform-pricing and nodalpricing markets....

  15. Efficient Algorithms for gcd and Cubic Residuosity in the Ring of Eisenstein Integers

    DEFF Research Database (Denmark)

    Damgård, Ivan Bjerre; Frandsen, Gudmund Skovbjerg

    2003-01-01

    and derived Jacobi symbol algorithms. Our algorithms take time O(n 2) for n bit input. This is an improvement from the known results based on the Euclidean algorithm, and taking time O(n M(n)), where M(n) denotes the complexity of multiplying n bit integers. The new algorithms have applications in practical...

  16. Red blood-cell alloantibodies in multiply transfused patients in the occupied Palestinian territory: a pilot study.

    Science.gov (United States)

    Yaseen, Ahmad; Suleiman, Sa'd; Zenah, Omar Abu; Abu Taha, Adham

    2018-02-21

    Red blood-cell transfusion has greatly reduced the mortality and morbidity in multiply transfused patients with thalassaemia and sickle cell disease. However, this can result in red blood-cell isoimmunisation with autoantibodies and alloantibodies, which can lead to serious complications such as delayed haemolytic transfusion reaction. The aim of this study was to assess the frequency and types of alloantibodies in multiply transfused patients living in the north of the West Bank. This pilot study was done at three thalassaemia centres in Nablus, Jenin, and Tulkarm in the occupied Palestinian territory where 300 patients with thalassaemia and sickle cell anaemia regularly receive blood transfusions. Alloantibody screening and identification were done using three-cell and eleven-cell panels (DiaPanel, Bio-rad, Switzerland) respectively. Ethical approval was obtained from Institutional Review Board Centre at Najah University. Written consent was obtained from participants. 131 patients were enrolled. Of the 20 (15%) patients with alloantibodies, 14 (70%) were diagnosed with β-thalassaemia major, three (15%) were diagnosed with sickle cell anaemia, two (10%) were diagnosed with thalassaemia intermedia, and one (5%) was diagnosed with sickle cell thalassaemia. 13 (65%) patients had alloantibodies that belonged to the Rh blood group system (nine [45%] patients had anti-D; two [10%] had anti-E; one [5%] had anti Rh-C; and one [5%] had anti-c). Anti-Kell was found in seven (35%) patients. Our data showed a quite high prevalence of alloimmunisation in multiply transfused patients. Rh and Kell blood group system antibodies were the only alloantibodies identified in this study. To reduce alloimmunisation, it will be essential to introduce a policy for extended red blood-cell phenotyping of these patients and for the issuing of antigen-matched blood (at least for Rh and Kell antigen). Najah National University. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. Robust fluence map optimization via alternating direction method of multipliers with empirical parameter optimization

    International Nuclear Information System (INIS)

    Gao, Hao

    2016-01-01

    For the treatment planning during intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT), beam fluence maps can be first optimized via fluence map optimization (FMO) under the given dose prescriptions and constraints to conformally deliver the radiation dose to the targets while sparing the organs-at-risk, and then segmented into deliverable MLC apertures via leaf or arc sequencing algorithms. This work is to develop an efficient algorithm for FMO based on alternating direction method of multipliers (ADMM). Here we consider FMO with the least-square cost function and non-negative fluence constraints, and its solution algorithm is based on ADMM, which is efficient and simple-to-implement. In addition, an empirical method for optimizing the ADMM parameter is developed to improve the robustness of the ADMM algorithm. The ADMM based FMO solver was benchmarked with the quadratic programming method based on the interior-point (IP) method using the CORT dataset. The comparison results suggested the ADMM solver had a similar plan quality with slightly smaller total objective function value than IP. A simple-to-implement ADMM based FMO solver with empirical parameter optimization is proposed for IMRT or VMAT. (paper)

  18. Detection of differential item functioning using Lagrange multiplier tests

    NARCIS (Netherlands)

    Glas, Cornelis A.W.

    1998-01-01

    Abstract: In the present paper it is shown that differential item functioning can be evaluated using the Lagrange multiplier test or Rao’s efficient score test. The test is presented in the framework of a number of IRT models such as the Rasch model, the OPLM, the 2-parameter logistic model, the

  19. Detection of differential item functioning using Lagrange multiplier tests

    NARCIS (Netherlands)

    Glas, Cornelis A.W.

    1996-01-01

    In this paper it is shown that differential item functioning can be evaluated using the Lagrange multiplier test or C. R. Rao's efficient score test. The test is presented in the framework of a number of item response theory (IRT) models such as the Rasch model, the one-parameter logistic model, the

  20. Multiplying Is More than Math--It's Also Good Management

    Science.gov (United States)

    Foster, Elise; Wiseman, Liz

    2015-01-01

    Studying more than 400 educational leaders, the authors propose a new model for leadership and management rooted in the belief that there is latent intelligence inside schools and educational organizations. Their findings suggest two dramatically different types of leaders, Multipliers and Diminishers. The five disciplines that distinguish…

  1. Garbage-free reversible constant multipliers for arbitrary integers

    DEFF Research Database (Denmark)

    Mogensen, Torben Ægidius

    2013-01-01

    We present a method for constructing reversible circuitry for multiplying integers by arbitrary integer constants. The method is based on Mealy machines and gives circuits whose size are (in the worst case) linear in the size of the constant. This makes the method unsuitable for large constants...

  2. Multipliers for the absolute Euler summability of Fourier series

    Indian Academy of Sciences (India)

    Springer Verlag Heidelberg #4 2048 1996 Dec 15 10:16:45

    (Math. Sci.), Vol. 111, No. 2, May 2001, pp. 203–219. Printed in India. Multipliers for the absolute Euler summability of Fourier series. PREM CHANDRA. School of Studies in Mathematics, Vikram University, Ujjain 456 010, India. MS received 30 December 1999; revised 30 October 2000. Abstract. In this paper, the author ...

  3. The role of the Jacobi last multiplier and isochronous systems

    Indian Academy of Sciences (India)

    pp. 917–927. The role of the Jacobi last multiplier and isochronous systems. PARTHA GUHA1,∗ and ANINDYA GHOSE CHOUDHURY2. 1S.N. Bose National Centre for Basic Sciences, JD Block, Sector III, Salt Lake,. Kolkata 700 098, India. 2Department of Physics, Surendranath College, 24/2 Mahatma Gandhi Road,.

  4. An algebra of absolutely continuous functions and its multipliers

    Indian Academy of Sciences (India)

    An example of a function which satisfies the necessary conditions but does not satisfy the sufficient conditions and fails to be a multiplier is also provided. 2. The Banach algebra ACp. ACp. ACp. Let I = [0, 1] with the usual interval topology be the compact metric space and C(I) be the set of all continuous complex valued ...

  5. A cascaded three-phase symmetrical multistage voltage multiplier

    International Nuclear Information System (INIS)

    Iqbal, Shahid; Singh, G K; Besar, R; Muhammad, G

    2006-01-01

    A cascaded three-phase symmetrical multistage Cockcroft-Walton voltage multiplier (CW-VM) is proposed in this report. It consists of three single-phase symmetrical voltage multipliers, which are connected in series at their smoothing columns like string of batteries and are driven by three-phase ac power source. The smoothing column of each voltage multiplier is charged twice every cycle independently by respective oscillating columns and discharged in series through load. The charging discharging process completes six times a cycle and therefore the output voltage ripple's frequency is of sixth order of the drive signal frequency. Thus the proposed approach eliminates the first five harmonic components of load generated voltage ripples and sixth harmonic is the major ripple component. The proposed cascaded three-phase symmetrical voltage multiplier has less than half the voltage ripple, and three times larger output voltage and output power than the conventional single-phase symmetrical CW-VM. Experimental and simulation results of the laboratory prototype are given to show the feasibility of proposed cascaded three-phase symmetrical CW-VM

  6. Fiscal multipliers over the growth cycle : evidence from Malaysia

    OpenAIRE

    Rafiq, Sohrab; Zeufack, Albert

    2012-01-01

    This paper explores the stabilisation properties of fiscal policy in Malaysia using a model incorporating nonlinearities into the dynamic relationship between fiscal policy and real economic activity over the growth cycle. The paper also investigates how output multipliers for government purchases may alter for different components of government spending. The authors find that fiscal polic...

  7. Smooth bifurcation for variational inequalities based on Lagrange multipliers

    Czech Academy of Sciences Publication Activity Database

    Eisner, Jan; Kučera, Milan; Recke, L.

    2006-01-01

    Roč. 19, č. 9 (2006), s. 981-1000 ISSN 0893-4983 R&D Projects: GA AV ČR(CZ) IAA100190506 Institutional research plan: CEZ:AV0Z10190503 Keywords : abstract variational inequality * bifurcation * Lagrange multipliers Subject RIV: BA - General Mathematics

  8. Multipliers of Ap((0 ,((0 ,((0,∞)) with order convolution

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Introduction. The algebra Ap(G) of elements in L1(G) whose Fourier transforms belong to Lp( ˆG) and the multipliers for these algebras have been studied by various authors [1,7–9]. Let. I = (0, ∞) be the locally compact idempotent commutative topological semigroup with the usual topology and max multiplication and ˆI be ...

  9. A database analysis of information on multiply charged ions

    International Nuclear Information System (INIS)

    Delcroix, J.L.

    1989-01-01

    A statistical analysis of data related to multiply charged ions, is performed in GAPHYOR data base: over-all statistics by ionization degree from q=1 to q=99, 'historical' development from 1975 to 1987, distribution (for q≥ 5) over physical processes (energy levels, charge exchange,...) and chemical elements

  10. Familiar Sports and Activities Adapted for Multiply Impaired Persons.

    Science.gov (United States)

    Schilling, Mary Lou, Ed.

    1984-01-01

    Means of adapting some familiar and popular physical activities for multiply impaired persons are described. Games reviewed are dice baseball, one base baseball, in-house bowling, wheelchair bowling, ramp bowling, swing-ball bowling, table tennis, shuffleboard, beanbag bingo and tic-tac-toe, balloon basketball, circle football, and wheelchair…

  11. Orientation and Mobility Training for the Multiply Handicapped Deaf.

    Science.gov (United States)

    Signorat, Monique; Watson, Arlyce

    1981-01-01

    An orientation and mobility curriculum for multiply handicapped deaf students incorporates instruction in environmental awareness concepts, orientation reference systems, route planning, and auditory training. Instruction frequently includes a solo travel experience. The roles of the classroom teacher and of the mobility instructor are noted. (CL)

  12. A CMOS four-quadrant analog current multiplier

    NARCIS (Netherlands)

    Wiegerink, Remco J.

    1991-01-01

    A CMOS four-quadrant analog current multiplier is described. The circuit is based on the square-law characteristic of an MOS transistor and is insensitive to temperature and process variations. The circuit is insensitive to the body effect so it is not necessary to place transistors in individual

  13. The evolution of unconditional strategies via the 'multiplier effect'.

    Science.gov (United States)

    McNamara, John M; Dall, Sasha R X

    2011-03-01

    Ostensibly, it makes sense in a changeable world to condition behaviour and development on information when it is available. Nevertheless, unconditional behavioural and life history strategies are widespread. Here, we show how intergenerational effects can limit the evolutionary value of responding to reliable environmental cues, and thus favour the evolutionary persistence of otherwise paradoxical unconditional strategies. While cue-ignoring genotypes do poorly in the wrong environments, in the right environment they will leave many copies of themselves, which will themselves leave many copies, and so on, leading genotypes to accumulate in habitats in which they do well. We call this 'The Multiplier Effect'. We explore the consequences of the multiplier effect by focussing on the ecologically important phenomenon of natal philopatry. We model the environment as a large number of temporally varying breeding sites connected by natal dispersal between sites. Our aim is to identify which aspects of an environment promote the multiplier effect. We show, if sites remain connected through some background level of 'accidental' dispersal, unconditional natal philopatry can evolve even when there is density dependence (with its accompanying kin competition effects), and cues that are only mildly erroneous. Thus, the multiplier effect may underpin the evolution and maintenance of unconditional strategies such as natal philopatry in many biological systems. © 2011 Blackwell Publishing Ltd/CNRS.

  14. Development and applications of gas electron multiplier detectors

    CERN Document Server

    Sauli, Fabio

    2003-01-01

    An overview of the recent developments in the field of gas electron multiplier (GEM) detectors was presented. Cascading of several GEM foils permits the sustaining of large gains and thereby allows the detection of minimum ionizing particles. The application of GEM included, fast and position sensitive detection in particle physics, medicine, neutron spectrometry, and astrophysics. (Edited abstract) 19 Refs.

  15. Robust formation control of marine surface craft using Lagrange multipliers

    DEFF Research Database (Denmark)

    Ihle, Ivar-Andre F.; Jouffroy, Jerome; Fossen, Thor I.

    2006-01-01

    This paper presents a formation modelling scheme based on a set of inter-body constraint functions and Lagrangian multipliers. Formation control for a °eet of marine craft is achieved by stabilizing the auxiliary constraints such that the desired formation con¯guration appears. In the proposed...

  16. Power system design optimization using Lagrange multiplier techniques

    Science.gov (United States)

    Yu, Y.; Lee, F. C.

    1981-01-01

    An optimization technique using the Lagrange Multiplier Method is proposed to facilitate design of switching power converter systems. The essence of the optimization is to identify the optimal battery voltage level and switching frequency along with the detailed converter design so that the total system weight including the battery and the packaged converter is minimized, and concurrently all specified power circuit performances are satisfied.

  17. Pictures at an Exhibition–A Lagrange Multiplier Gallery

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 12. Pictures at an Exhibition – A Lagrange Multiplier Gallery. Vivek S Borkar. Classroom Volume 3 ... Author Affiliations. Vivek S Borkar1. Department of Computer Science and Automation, Indian Institute of Science, Bangalore 560 012, India ...

  18. A LOW-PHASE NOISE FREQUENCY MULTIPLIER CHAIN ...

    African Journals Online (AJOL)

    ABSTRACT. In this paper a low phase-noise frequency multiplier chain from lOMHz to 480MHz, built in two stages and intended for use as a base for the synthesis of frequencies upto the far infrared. (FIR) region, is presented. Different methods of frequency multiplication were used and the associated circuit diagrams given.

  19. Doubly Constrained Robust Blind Beamforming Algorithm

    Directory of Open Access Journals (Sweden)

    Xin Song

    2013-01-01

    Full Text Available We propose doubly constrained robust least-squares constant modulus algorithm (LSCMA to solve the problem of signal steering vector mismatches via the Bayesian method and worst-case performance optimization, which is based on the mismatches between the actual and presumed steering vectors. The weight vector is iteratively updated with penalty for the worst-case signal steering vector by the partial Taylor-series expansion and Lagrange multiplier method, in which the Lagrange multipliers can be optimally derived and incorporated at each step. A theoretical analysis for our proposed algorithm in terms of complexity cost, convergence performance, and SINR performance is presented in this paper. In contrast to the linearly constrained LSCMA, the proposed algorithm provides better robustness against the signal steering vector mismatches, yields higher signal captive performance, improves greater array output SINR, and has a lower computational cost. The simulation results confirm the superiority of the proposed algorithm on beampattern control and output SINR enhancement.

  20. Design of multichannel DWDM fiber Bragg grating filters by Lagrange multiplier constrained optimization.

    Science.gov (United States)

    Lee, Cheng-Ling; Lee, Ray-Kuang; Kao, Yee-Mou

    2006-11-13

    We present the synthesis of multi-channel fiber Bragg grating (MCFBG) filters for dense wavelength-division-multiplexing (DWDM) application by using a simple optimization approach based on a Lagrange multiplier optimization (LMO) method. We demonstrate for the first time that the LMO method can be used to constrain various parameters of the designed MCFBG filters for practical application demands and fabrication requirements. The designed filters have a number of merits, i.e., flat-top and low dispersion spectral response as well as single stage. Above all, the maximum amplitude of the index modulation profiles of the designed MCFBGs can be substantially reduced under the applied constrained condition. The simulation results demonstrate that the LMO algorithm can provide a potential alternative for complex fiber grating filter design problems.

  1. Efficient design of multiplier-less digital channelizers using recombination non-uniform filter banks

    Directory of Open Access Journals (Sweden)

    Shaeen Kalathil

    2018-01-01

    Full Text Available A novel approach for the efficient realization of digital channelizers in software defined radios using recombination filter banks is proposed in this paper. Digital channelizer is the core of software defined radio. Computationally efficient design supporting multiple channels with different bandwidths and low complexity are inevitable requirements for the digital channelizers. Recombination filter banks method is used to obtain non-uniform filter banks with rational sampling factors, using a two stage structure. It consists of a uniform filter bank and trans-multiplexer. In this work, the uniform filter bank and trans-multiplexer are designed using cosine modulated filter banks. The prototype filter design is made simple, efficient and fast, using window method. The multiplier-less realization of recombination filter banks in the canonic signed digit space using nature inspired optimization algorithms, results in reduced implementation complexity.

  2. A generic optimization algorithm for the allocation of DP actuators

    NARCIS (Netherlands)

    van Daalen, E.F.G.; Cozijn, J.L.; Loussouarn, C.; Hemker, P.W.

    2011-01-01

    In this paper we present a generic optimization algorithm for the allocation of dynamic positioning actuators, such as azimuthing thrusters and fixed thrusters. The algorithm is based on the well-known Lagrange multipliers method. In the present approach the Lagrangian functional represents not only

  3. Algorithming the Algorithm

    DEFF Research Database (Denmark)

    Mahnke, Martina; Uprichard, Emma

    2014-01-01

    changes: it’s not the ocean, it’s the internet we’re talking about, and it’s not a TV show producer, but algorithms that constitute a sort of invisible wall. Building on this assumption, most research is trying to ‘tame the algorithmic tiger’. While this is a valuable and often inspiring approach, we...

  4. Generation of fast multiply charged ions in conical targets

    International Nuclear Information System (INIS)

    Demchenko, V.V.; Chukbar, K.V.

    1990-01-01

    So-called conical targets, when the thermonuclear fuel is compressed and heated in a conical cavity in a heavy material (lead, gold, etc.) with the help of a spherical segment that is accelerated by a laser pulse or a beam of charged particles, are often employed in experimental studies of inertial-confinement fusion. In spite of the obvious advantages of such a scheme, one of which is a significant reduction of the required energy input compared with the complete spherical target, it also introduces additional effects into the process of cumulation of energy. In this paper the authors call attention to an effect observed in numerical calculations: the hydrodynamic heating of a small group of multiply charged heavy ions of the walls of the conical cavity up to high energies (T i approx-gt 100 keV). This effect ultimately occurs as a result of the high radiation losses of a multiply charged plasma

  5. Study of multi anode photo multiplier tubes at low gains

    CERN Document Server

    Eisenhardt, S; Bibby, J; Libby, J

    2001-01-01

    We describe a preliminary study of the signal shape of the Multianode Photo Multiplier Tubes (MaPMT) at low gain. We investigate the feasibility of running the MaPMT at gains of around 30000 e which would allow to use front-end chips that have been developed for silicon detectors or micro strip gas chambers. In addition we have investigated the focusing properties of an improved design of the MaPMT.

  6. Radial multipliers on reduced free products of operator algebras

    DEFF Research Database (Denmark)

    Haagerup, Uffe; Møller, Søren

    2012-01-01

    Let AiAi be a family of unital C¿C¿-algebras, respectively, of von Neumann algebras and ¿:N0¿C¿:N0¿C. We show that if a Hankel matrix related to ¿ is trace-class, then there exists a unique completely bounded map M¿M¿ on the reduced free product of the AiAi, which acts as a radial multiplier...

  7. Radial multipliers on reduced free products of operator algebras

    DEFF Research Database (Denmark)

    Haagerup, Uffe; Møller, Søren

    2012-01-01

    Let AiAi be a family of unital C¿C¿-algebras, respectively, of von Neumann algebras and ¿:N0¿C¿:N0¿C. We show that if a Hankel matrix related to ¿ is trace-class, then there exists a unique completely bounded map M¿M¿ on the reduced free product of the AiAi, which acts as a radial multiplier. Her...

  8. Representation of the inverse of a frame multiplier

    OpenAIRE

    Balazs, Peter; Stoeva, Diana T.

    2011-01-01

    Certain mathematical objects appear in a lot of scientific disciplines, like physics, signal processing and, naturally, mathematics. In a general setting they can be described as frame multipliers, consisting of analysis, multiplication by a fixed sequence (called the symbol), and synthesis. In this paper we show a surprising result about the inverse of such operators, if any, as well as new results about a core concept of frame theory, dual frames. We show that for semi-normalized symbols, t...

  9. Multiply-negatively charged aluminium clusters and fullerenes

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, Noelle

    2008-07-15

    Multiply negatively charged aluminium clusters and fullerenes were generated in a Penning trap using the 'electron-bath' technique. Aluminium monoanions were generated using a laser vaporisation source. After this, two-, three- and four-times negatively charged aluminium clusters were generated for the first time. This research marks the first observation of tetra-anionic metal clusters in the gas phase. Additionally, doubly-negatively charged fullerenes were generated. The smallest fullerene dianion observed contained 70 atoms. (orig.)

  10. Multiplier convergent series and uniform convergence of mapping ...

    Indian Academy of Sciences (India)

    convergent in the norm topology. We denote the vector-valued sequence set consisting of λ-multiplier convergent series by. MCλ(X) = ⎧. ⎨. ⎩. (xj ) ∈ X. N : ∞. ∑ j=1 tj xj converges for each (tj ) ∈ λ. ⎫. ⎬. ⎭ . As we know, the study of β-dual of sequence spaces is an interesting topic in analysis. [2, 3, 6]. For topological vector ...

  11. Characterization of a prototype matrix of Silicon PhotoMultipliers

    Energy Technology Data Exchange (ETDEWEB)

    Dinu, N. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France)], E-mail: dinu@lal.in2p3.fr; Barrillon, P.; Bazin, C. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Belcari, N.; Bisogni, M.G. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); Bondil-Blin, S. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Boscardin, M. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy); Chaumat, V. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Collazuol, G. [Scuola Normale Superiore (SNS), 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); De La Taille, C. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Del Guerra, A. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); Llosa, G. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); Marcatili, S. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); Melchiorri, M.; Piemonte, C. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy); Puill, V. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Tarolli, A. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy); Vagnucci, J.F. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Zorzi, N. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy)

    2009-10-21

    This work reports on the electrical as well as the optical characterizations of a prototype matrix of Silicon PhotoMultipliers (SiPM). The electrical test consists of the measurement of the static (breakdown voltage, quenching resistance, post-breakdown dark current) as well as the dynamic characteristics (gain, dark count rate). The optical test consists of the estimation of the photon detection efficiency as a function of wavelength as well as operation voltage.

  12. Characterization of a prototype matrix of Silicon PhotoMultipliers

    International Nuclear Information System (INIS)

    Dinu, N.; Barrillon, P.; Bazin, C.; Belcari, N.; Bisogni, M.G.; Bondil-Blin, S.; Boscardin, M.; Chaumat, V.; Collazuol, G.; De La Taille, C.; Del Guerra, A.; Llosa, G.; Marcatili, S.; Melchiorri, M.; Piemonte, C.; Puill, V.; Tarolli, A.; Vagnucci, J.F.; Zorzi, N.

    2009-01-01

    This work reports on the electrical as well as the optical characterizations of a prototype matrix of Silicon PhotoMultipliers (SiPM). The electrical test consists of the measurement of the static (breakdown voltage, quenching resistance, post-breakdown dark current) as well as the dynamic characteristics (gain, dark count rate). The optical test consists of the estimation of the photon detection efficiency as a function of wavelength as well as operation voltage.

  13. Small and orthodox fiscal multipliers at the zero lower bound

    OpenAIRE

    Braun, R. Anton; Korber, Lena Mareen; Waki, Yuichiro

    2013-01-01

    Does fiscal policy have large and qualitatively different effects on the economy when the nominal interest rate is zero? An emerging consensus in the New Keynesian literature is that the answer is yes. New evidence provided here suggests that the answer is often no. For a broad range of empirically relevant parameterizations of the Rotemberg model of costly price adjustment, the government purchase multiplier is about one or less, and the response of hours to a tax cut is either negative or c...

  14. Inverse mass matrix via the method of localized lagrange multipliers

    Czech Academy of Sciences Publication Activity Database

    González, José A.; Kolman, Radek; Cho, S.S.; Felippa, C.A.; Park, K.C.

    2018-01-01

    Roč. 113, č. 2 (2018), s. 277-295 ISSN 0029-5981 R&D Projects: GA MŠk(CZ) EF15_003/0000493; GA ČR GA17-22615S Institutional support: RVO:61388998 Keywords : explicit time integration * inverse mass matrix * localized Lagrange multipliers * partitioned analysis Subject RIV: BI - Acoustics OBOR OECD: Applied mechanics Impact factor: 2.162, year: 2016 https://onlinelibrary.wiley.com/doi/10.1002/nme.5613

  15. On Lagrange Multipliers in Work with Quality and Reliability Assurance

    DEFF Research Database (Denmark)

    Vidal, Rene Victor Valqui; Becker, P.

    1986-01-01

    In optimizing some property of a system, reliability say, a designer usually has to accept certain constraints regarding cost, completion time, volume, weight, etc. The solution of optimization problems with boundary constraints can be helped substantially by the use of Lagrange multipliers...... in the areas of sales promotion and teaching. These maps illuminate the logic structure of solution sequences. One such map is shown, illustrating the application of LMT in one of the examples....

  16. Safety analysis report for the Neutron Multiplier Facility, 329 Building

    International Nuclear Information System (INIS)

    Rieck, H.G.

    1978-09-01

    Neutron multiplication is a process wherein the flux of a neutron source such as 252 Cf is enhanced by fission reactions that occur in a subcritical assemblage of fissile material. The multiplication factor of the device depends upon the consequences of neutron reactions with matter and is independent of the initial number of neutrons present. Safe utilization of such a device demands that the fissile material assemblage be maintained in a subcritical state throughout all normal and credibly abnormal conditions. Examples of things that can alter the multiplication factor (and degree of subcriticality) are temperature fluctuations, changes in moderator material such as voiding or composition, addition of fissile materials, and change in assembly configuration. The Neutron Multiplier Facility (NMF) utilizes a multiplier- 252 Cf assembly to produce neutrons for activation analysis of organic and inorganic environmental samples and for on-line mass spectrometry analysis of fission products which diffuse from a stationary fissile target (less than or equal to 4 g fissile material) located in the Neutron Multiplier. The NMF annex to the 329 Building provides close proximity to related counting equipment, and delay between sample irradiation and counting is minimized

  17. A Novel Synthesizing Genetic Logic Circuit: Frequency Multiplier.

    Science.gov (United States)

    Chuang, Chia-Hua; Lin, Chun-Liang

    2014-01-01

    This paper presents a novel synthesizing genetic logic circuit design based on an existing synthetic genetic oscillator, which provides a function of frequency multiplier to synthesize a clock signal whose frequency is a multiple of that of the genetic oscillator. In the renowned literature, the synthetic genetic oscillator, known as a repressilator, has been successfully built in Escherichia coli to generate a periodic oscillating phenomenon through three repressive genes repress each other in a chain. On the basis of this fact, our proposed genetic frequency multiplier circuit utilizes genetic Buffers in series with a waveform-shaping circuit to reshape the genetic oscillation signal into a crisp logic clock signal. By regulating different threshold levels in the Buffer, the time length of logic high/low levels in a fundamental sinusoidal wave can be engineered to pulse-width-modulated (PWM) signals with various duty cycles. Integrating some of genetic logic XOR gates and PWM signals from the output of the Buffers, a genetic frequency multiplier circuit can be created and the clock signal with the integer-fold of frequency of the genetic oscillator is generated. The synthesized signal can be used in triggering the downstream digital genetic logic circuits. Simulation results show the applicability of the proposed idea.

  18. Charge amplification and transfer processes in the gas electron multiplier

    International Nuclear Information System (INIS)

    Bachmann, S.; Bressan, A.; Ropelewski, L.; Sauli, F.; Sharma, A.; Moermann, D.

    1999-01-01

    We report the results of systematic investigations on the operating properties of detectors based on the gas electron multiplier (GEM). The dependence of gain and charge collection efficiency on the external fields has been studied in a range of values for the hole diameter and pitch. The collection efficiency of ionization electrons into the multiplier, after an initial increase, reaches a plateau extending to higher values of drift field the larger the GEM voltage and its optical transparency. The effective gain, fraction of electrons collected by an electrode following the multiplier, increases almost linearly with the collection field, until entering a steeper parallel plate multiplication regime. The maximum effective gain attainable increases with the reduction in the hole diameter, stabilizing to a constant value at a diameter approximately corresponding to the foil thickness. Charge transfer properties appear to depend only on ratios of fields outside and within the channels, with no interaction between the external fields. With proper design, GEM detectors can be optimized to satisfy a wide range of experimental requirements: tracking of minimum ionizing particles, good electron collection with small distortions in high magnetic fields, improved multi-track resolution and strong ion feedback suppression in large volume and time-projection chambers

  19. Two-Switch Voltage Equalizer Using a Series-Resonant Voltage Multiplier Operating in Frequency-Multiplied Discontinuous Conduction Mode for Series-Connected Supercapacitors

    OpenAIRE

    Uno, Masatoshi; Kukita, Akio

    2015-01-01

    Cell voltage equalizers are necessary to ensure years of operation and maximize the chargeable/dischargeable energy of series-connected supercapacitors (SCs). A two-switch voltage equalizer using a series-resonant voltage multiplier operating in frequency-multiplied discontinuous conduction mode (DCM) is proposed for series-connected SCs in this paper. The frequency-multiplied mode virtually increases the operation frequency and hence mitigates the negative impact of the impedance mismatch of...

  20. Performance Analysis of a 32-Bit Multiplier with a Carry-Look-Ahead Adder and a 32-bit Multiplier with a Ripple Adder using VHDL

    OpenAIRE

    Hasan Krad; Aws Y. Al-Taie

    2008-01-01

    This study presents a performance analysis of two different multipliers for unsigned data, one uses a carry-look-ahead adder and the second one uses a ripple adder. The study's main focus is on the speed of the multiplication operation on these 32-bit multipliers which are modeled using VHDL, A hardware description language. The multiplier with a carry-look-ahead adder has shown a better performance over the multiplier with a ripple adder in terms of gate delays. Under the worst case, the mul...

  1. AntigenMap 3D: an online antigenic cartography resource.

    Science.gov (United States)

    Barnett, J Lamar; Yang, Jialiang; Cai, Zhipeng; Zhang, Tong; Wan, Xiu-Feng

    2012-05-01

    Antigenic cartography is a useful technique to visualize and minimize errors in immunological data by projecting antigens to 2D or 3D cartography. However, a 2D cartography may not be sufficient to capture the antigenic relationship from high-dimensional immunological data. AntigenMap 3D presents an online, interactive, and robust 3D antigenic cartography construction and visualization resource. AntigenMap 3D can be applied to identify antigenic variants and vaccine strain candidates for pathogens with rapid antigenic variations, such as influenza A virus. http://sysbio.cvm.msstate.edu/AntigenMap3D

  2. Antigens of Streptococcus sanguis

    Science.gov (United States)

    Rosan, Burton

    1973-01-01

    An antigenic analysis of the alpha-hemolytic streptococci isolated from dental plaque was performed by use of antisera against a strain of Streptococcus sanguis (M-5) which was isolated from dental plaque. Immunoelectrophoretic and Ouchterlony tests of Rantz and Randall extracts of 45 strains gave positive reactions with the M-5 antisera. These strains represented 60% of the strains tested. The number of antigens which could be identified in these extracts varied from one to five and were designated a to e. The a antigen was found in 36 of the strains tested, including reference strains of S. sanguis and the group H streptococci. The strains reacting with the M-5 antisera were divided into two majors types: type I consisted of 23 strains in which the a antigen was found alone or with one or more of the c, d, and e antigens; type II consisted of 13 strains in which both the a and b antigens were found with or without one or more of the c, d, and e antigens. The remaining strains contained, either singly or in combination, the b, c, d, and e antigens but not the a antigen. Biochemical tests of representatives of each serotype and reference strains indicated that strains reacting with M-5 antisera were S. sanguis. These findings suggest that S. sanguis strains share common physiological and serological properties. Images PMID:4633291

  3. Auditing the multiply-related concepts within the UMLS.

    Science.gov (United States)

    Mougin, Fleur; Grabar, Natalia

    2014-10-01

    This work focuses on multiply-related Unified Medical Language System (UMLS) concepts, that is, concepts associated through multiple relations. The relations involved in such situations are audited to determine whether they are provided by source vocabularies or result from the integration of these vocabularies within the UMLS. We study the compatibility of the multiple relations which associate the concepts under investigation and try to explain the reason why they co-occur. Towards this end, we analyze the relations both at the concept and term levels. In addition, we randomly select 288 concepts associated through contradictory relations and manually analyze them. At the UMLS scale, only 0.7% of combinations of relations are contradictory, while homogeneous combinations are observed in one-third of situations. At the scale of source vocabularies, one-third do not contain more than one relation between the concepts under investigation. Among the remaining source vocabularies, seven of them mainly present multiple non-homogeneous relations between terms. Analysis at the term level also shows that only in a quarter of cases are the source vocabularies responsible for the presence of multiply-related concepts in the UMLS. These results are available at: http://www.isped.u-bordeaux2.fr/ArticleJAMIA/results_multiply_related_concepts.aspx. Manual analysis was useful to explain the conceptualization difference in relations between terms across source vocabularies. The exploitation of source relations was helpful for understanding why some source vocabularies describe multiple relations between a given pair of terms. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  4. Fission multipliers for D-D/D-T neutron generators

    International Nuclear Information System (INIS)

    Lou, T.P.; Vujic, J.L.; Koivunoro, H.; Reijonen, J.; Leung, K.-N.

    2003-01-01

    A compact D-D/D-T fusion based neutron generator is being designed at the Lawrence Berkeley National Laboratory to have a potential yield of 10 12 D-D n/s and 10 14 D-T n/s. Because of its high neutron yield and compact size (∼20 cm in diameter by 4 cm long), this neutron generator design will be suitable for many applications. However, some applications required higher flux available from nuclear reactors and spallation neutron sources operated with GeV proton beams. In this study, a subcritical fission multiplier with k eff of 0.98 is coupled with the compact neutron generators in order to increase the neutron flux output. We have chosen two applications to show the gain in flux due to the use of fission multipliers--in-core irradiation and out-of-core irradiation. For the in-core irradiation, we have shown that a gain of ∼25 can be achieved in a positron production system using D-T generator. For the out-of-core irradiation, a gain of ∼17 times is obtained in Boron Neutron Capture Therapy (BNCT) using a D-D neutron generator. The total number of fission neutrons generated by a source neutron in a fission multiplier with k eff is ∼50. For the out-of-core irradiation, the theoretical maximum net multiplication is ∼30 due to the absorption of neutrons in the fuel. A discussion of the achievable multiplication and the theoretical multiplication will be presented in this paper

  5. Multipliers of weighted semigroups and associated Beurling Banach ...

    Indian Academy of Sciences (India)

    The class of multipliers on S is denoted by M(S). The set M(S) is a unital, abelian semigroup under the operation composition. For s ∈ S, define Ls : S → S as Ls(t) = st, t ∈ S. Then Ls ∈ M(S), and Ls Lt = Lst, s, t ∈ S. A semigroup S is faithful if for s, t ∈ S, su = tu for all u ∈ S implies s = t. Thus S is identified with an ideal of ...

  6. Science with multiply-charged ions at Brookhaven National Laboratory

    International Nuclear Information System (INIS)

    Jones, K.W.; Johnson, B.M.; Meron, M.; Thieberger, P.

    1987-01-01

    The production of multiply-charged heavy ions at Brookhaven National Laboratory and their use in different types of experiments are discussed. The main facilities that are used are the Double MP Tandem Van de Graaff and the National Synchrotron Light Source. The capabilities of a versatile Atomic Physics Facility based on a combination of the two facilities and a possible new heavy-ion storage ring are summarized. It is emphasized that the production of heavy ions and the relevant science necessitates very flexible and diverse apparatus

  7. Statistics of electron multiplication in multiplier phototube: iterative method

    International Nuclear Information System (INIS)

    Grau Malonda, A.; Ortiz Sanchez, J.F.

    1985-01-01

    An iterative method is applied to study the variation of dynode response in the multiplier phototube. Three different situations are considered that correspond to the following ways of electronic incidence on the first dynode: incidence of exactly one electron, incidence of exactly r electrons and incidence of an average anti-r electrons. The responses are given for a number of steps between 1 and 5, and for values of the multiplication factor of 2.1, 2.5, 3 and 5. We study also the variance, the skewness and the excess of jurtosis for different multiplication factors. (author)

  8. Determination of Ultimate Torque for Multiply Connected Cross Section Rod

    Directory of Open Access Journals (Sweden)

    V. L. Danilov

    2015-01-01

    Full Text Available The aim of this work is to determine load-carrying capability of the multiply cross-section rod. This calculation is based on the model of the ideal plasticity of the material, so that the desired ultimate torque is a torque at which the entire cross section goes into a plastic state.The article discusses the cylindrical multiply cross-section rod. To satisfy the equilibrium equation and the condition of plasticity simultaneously, two stress function Ф and φ are introduced. By mathematical transformations it has been proved that Ф is constant along the path, and a formula to find its values on the contours has been obtained. The paper also presents the rationale of the line of stress discontinuity and obtained relationships, which allow us to derive the equations break lines for simple interaction of neighboring circuits, such as two lines, straight lines and circles, circles and a different sign of the curvature.After substitution into the boundary condition at the end of the stress function Ф and mathematical transformations a formula is obtained to determine the ultimate torque for the multiply cross-section rod.Using the doubly connected cross-section and three-connected cross-section rods as an example the application of the formula of ultimate torque is studied.For doubly connected cross-section rod, the paper offers a formula of the torque versus the radius of the rod, the aperture radius and the distance between their centers. It also clearly demonstrates the torque dependence both on the ratio of the radii and on the displacement of hole. It is shown that the value of the torque is more influenced by the displacement of hole, rather than by the ratio of the radii.For the three-connected cross-section rod the paper shows the integration feature that consists in selection of a coordinate system. As an example, the ultimate torque is found by two methods: analytical one and 3D modeling. The method of 3D modeling is based on the Nadai

  9. Radiation imaging with glass gas electron multipliers (G -GEMs)

    Science.gov (United States)

    Fujiwara, Takeshi; Mitsuya, Yuki; Takahashi, Hiroyuki

    2018-01-01

    This review investigates the advantages and disadvantages of gaseous radiation detectors when compared with solid-state detectors, for use in radiation imaging, which are caused by the differing properties of gases and solids. Imaging applications for which micro-pattern gas detectors (MPGDs) are superior, include neutron imaging, high-linear-energy-transfer (LET) radiation imaging, and low-energy-depositing radiation imaging. This paper is focused on these applications where MPGDs, in particular, the glass gas electron multiplier (G-GEM), are superior, and their development is described and relevant experimental results are discussed.

  10. Statistics of electron multiplication in a multiplier phototube; Iterative method

    International Nuclear Information System (INIS)

    Ortiz, J. F.; Grau, A.

    1985-01-01

    In the present paper an iterative method is applied to study the variation of dynode response in the multiplier phototube. Three different situation are considered that correspond to the following ways of electronic incidence on the first dynode: incidence of exactly one electron, incidence of exactly r electrons and incidence of an average r electrons. The responses are given for a number of steps between 1 and 5, and for values of the multiplication factor of 2.1, 2.5, 3 and 5. We study also the variance, the skewness and the excess of jurtosis for different multiplication factors. (Author) 11 refs

  11. Charge-transfer properties in the gas electron multiplier

    International Nuclear Information System (INIS)

    Han, Sanghyo; Kim, Yongkyun; Cho, Hyosung

    2004-01-01

    The charge transfer properties of a gas electron multiplier (GEM) were systematically investigated over a broad range of electric field configurations. The electron collection efficiency and the charge sharing were found to depend on the external fields, as well as on the GEM voltage. The electron collection efficiency increased with the collection field up to 90%, but was essentially independent of the drift field strength. A double conical GEM has a 10% gain increase with time due to surface charging by avalanche ions whereas this effect was eliminated with the cylindrical GEM. The positive-ion feedback is also estimated. (author)

  12. Convergence of a Substructuring Method with LaGrange Multipliers

    Science.gov (United States)

    Mandel, Jan; Tezaur, Radek

    1996-01-01

    We analyze the convergence of a substructuring iterative method with Lagrange multipliers, proposed recently by Farhat and Roux. The method decomposes finite element discretization of an elliptic boundary value problem into Neumann problems on the subdomains and a coarse problem for the subdomain nullspace components. For linear conforming elements and preconditioning by the Dirichlet problems on the subdomains, we prove the asymptotic bound on the condition number C(1 + log(H/h))(sup gamma), gamma = 2 or 3, where h is the characteristic element size and H is the subdomain size.

  13. 233U breeding and neutron multiplying blankets for fusion reactors

    International Nuclear Information System (INIS)

    Cook, A.G.; Maniscalco, J.A.

    1975-01-01

    In this work, along with a previous paper three possible uses of 14-MeV deuterium--tritium fusion neutrons are investigated: energy production, neutron multiplication, and fissile-fuel breeding. The results presented include neutronic studies of fissioning and nonfissioning thorium systems, tritium breeding systems, various fuel options (UO 2 , UC, UC 2 , etc.), and uranium as well as refractory metal first-wall neutron-multiplying regions. A brief energy balance and an estimate of potential revenues for fusion devices are given to help illustrate the potentials of these designs

  14. Group-Based Alternating Direction Method of Multipliers for Distributed Linear Classification.

    Science.gov (United States)

    Wang, Huihui; Gao, Yang; Shi, Yinghuan; Wang, Ruili

    2017-11-01

    The alternating direction method of multipliers (ADMM) algorithm has been widely employed for distributed machine learning tasks. However, it suffers from several limitations, e.g., a relative low convergence speed, and an expensive time cost. To this end, in this paper, a novel method, namely the group-based ADMM (GADMM), is proposed for distributed linear classification. In particular, to accelerate the convergence speed and improve global consensus, a group layer is first utilized in GADMM to divide all the slave nodes into several groups. Then, all the local variables (from the slave nodes) are gathered in the group layer to generate different group variables. Finally, by using a weighted average method, the group variables are coordinated to update the global variable (from the master node) until the solution of the global problem is reached. According to the theoretical analysis, we found that: 1) GADMM can mathematically converge at the rate , where is the number of outer iterations and 2) by using the grouping methods, GADMM can improve the convergence speed compared with the distributed ADMM framework without grouping methods. Moreover, we systematically evaluate GADMM on four publicly available LIBSVM datasets. Compared with disADMM and stochastic dual coordinate ascent with alternating direction method of multipliers-ADMM, for distributed classification, GADMM is able to reduce the number of outer iterations, which leads to faster convergence speed and better global consensus. In particular, the statistical significance test has been experimentally conducted and the results validate that GADMM can significantly save up to 30% of the total time cost (with less than 0.6% accuracy loss) compared with disADMM on large-scale datasets, e.g., webspam and epsilon.

  15. Eosinofil Sel Penyaji Antigen

    Directory of Open Access Journals (Sweden)

    Safari Wahyu Jatmiko

    2015-04-01

    Full Text Available Sel eosinofil merupakan jenis sel lekosit yang terlibat dalam berbagai patogenesis penyakit. Sel eosinofil pada awalnya dikenal sebagai sel efektor  dari sistem imunitas alamiah. Akan tetapi, kemampuan sel eosinofil dalam memfagositosis patogen menimbulkan dugaan bahwa sel eosinofil ikut berperan sebagai sel penyaji antigen. Hal ini dianalogikan dengan sel makrofag dan sel dendritik yang bisa memfagositosis dan menyajikan antigen sebagai hasil dari degradasi patogen yang difagositosis. Untuk menjawab permasalahan ini, penulis melakukan penelusuran artikel tentang eosinofil sebagai sel penyaji antigen melalui US National Library of Medicine National Institute of Healthdengan kata kunci eoshinophil dan antigen presenting cell. Hasil penelusuran adalah ditemukannya 10 artikel yang relevan dengan topik. Hasil dari sintesis kesepuluh jurnal tersebut adalah sel eosinofil mampu berperan sebagai sel penyaji antigen yang profesional (professionalantigenpresentng cell

  16. Human leucocyte antigens in patients with alcoholic liver cirrhosis

    DEFF Research Database (Denmark)

    Gluud, C; Aldershvile, J; Dietrichson, O

    1980-01-01

    No significant differences in the frequencies of HLA-B8, -B40, and other HLA-A, -B, and -C phenotypes were found among patients with histologically verified alcoholic cirrhosis compared with normal controls when the p values were multiplied by the number of comparisons. This was found both...... in the present study of 45 patients and in the combined data of this and three other similar studies. However, these findings do not rule out that alcoholic cirrhosis might be associated with HLA factors (for example. HLA-D/DR antigens) controlling immune responses....

  17. Compliant displacement-multiplying apparatus for microelectromechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Kota, Sridhar (9391 Quail Ridge Run, Brighton, MI 48114); Rodgers, M. Steven (12216 Papaya Ct., NE., Albuquerque, NM 87111); Hetrick, Joel A. (818 S. Gammon, Apartment 4, Madison, WI 53719)

    2001-01-01

    A pivotless compliant structure is disclosed that can be used to increase the geometric advantage or mechanical advantage of a microelectromechanical (MEM) actuator such as an electrostatic comb actuator, a capacitive-plate electrostatic actuator, or a thermal actuator. The compliant structure, based on a combination of interconnected flexible beams and cross-beams formed of one or more layers of polysilicon or silicon nitride, can provide a geometric advantage of from about 5:1 to about 60:1 to multiply a 0.25-3 .mu.m displacement provided by a short-stroke actuator so that such an actuator can be used to generate a displacement stroke of about 10-34 .mu.m to operate a ratchet-driven MEM device or a microengine. The compliant structure has less play than conventional displacement-multiplying devices based on lever arms and pivoting joints, and is expected to be more reliable than such devices. The compliant structure and an associated electrostatic or thermal actuator can be formed on a common substrate (e.g. silicon) using surface micromachining.

  18. Image restorations constrained by a multiply exposed picture

    International Nuclear Information System (INIS)

    Breedlove, J.R. Jr.; Kruger, R.P.; Trussell, H.J.; Hunt, B.R.

    1977-01-01

    There are a number of possible industrial and scientific applications of nanosecond cineradiographs. While the technology exists to produce closely spaced pulses of x rays for this application, the quality of the time-resolved radiographs is severely limited. The limitations arise from the necessity of using a fluorescent screen to convert the transmitted x rays to light and then using electro-optical imaging systems to gate and to record the images with conventional high-speed cameras. It has been proposed that in addition to the time-resolved images, a conventional multiply-exposed radiograph be obtained. Simulations are used to demonstrate that the additional information supplied by the multiply-exposed radiograph can be used to improve the quality of digital image restorations of the time-resolved pictures over what could be achieved with the degraded images alone. Because of the need for image registration and rubber sheet transformations, this problem is one which can best be solved on a digital, as opposed to an optical, computer

  19. Imaging moving objects from multiply scattered waves and multiple sensors

    International Nuclear Information System (INIS)

    Miranda, Analee; Cheney, Margaret

    2013-01-01

    In this paper, we develop a linearized imaging theory that combines the spatial, temporal and spectral components of multiply scattered waves as they scatter from moving objects. In particular, we consider the case of multiple fixed sensors transmitting and receiving information from multiply scattered waves. We use a priori information about the multipath background. We use a simple model for multiple scattering, namely scattering from a fixed, perfectly reflecting (mirror) plane. We base our image reconstruction and velocity estimation technique on a modification of a filtered backprojection method that produces a phase-space image. We plot examples of point-spread functions for different geometries and waveforms, and from these plots, we estimate the resolution in space and velocity. Through this analysis, we are able to identify how the imaging system depends on parameters such as bandwidth and number of sensors. We ultimately show that enhanced phase-space resolution for a distribution of moving and stationary targets in a multipath environment may be achieved using multiple sensors. (paper)

  20. Multiplied effect of heat and radiation in chemical stress relaxation

    International Nuclear Information System (INIS)

    Ito, Masayuki

    1981-01-01

    About the deterioration of rubber due to radiation, useful knowledge can be obtained by the measurement of chemical stress relaxation. As an example, the rubber coating of cables in a reactor containment vessel is estimated to be irradiated by weak radiation at the temperature between 60 and 90 deg C for about 40 years. In such case, it is desirable to establish the method of accelerated test of the deterioration. The author showed previously that the law of time-dose rate conversion holds in the case of radiation. In this study, the chemical stress relaxation to rubber was measured by the simultaneous application of heat and radiation, and it was found that there was the multiplied effect of heat and radiation in the stress relaxation speed. Therefore the factor of multiplication of heat and radiation was proposed to describe quantitatively the degree of the multiplied effect. The chloroprene rubber used was offered by Hitachi Cable Co., Ltd. The experimental method and the results are reported. The multiplication of heat and radiation is not caused by the direct cut of molecular chains by radiation, instead, it is based on the temperature dependence of various reaction rates at which the activated species reached the cut of molecular chains through complex reaction mechanism and the temperature dependence of the diffusion rate of oxygen in rubber. (Kako, I.)

  1. Auger transitions in singly and multiply ionized atoms

    International Nuclear Information System (INIS)

    Mehlhorn, W.

    1978-01-01

    Some recent progress in Auger and autoionizing electron spectrometry of free metal atoms and of multiply ionized atoms is reviewed. The differences which arise between the spectra of atoms in the gaseous and the solid state are due to solid state effects. This will be shown for Cd as an example. The super Coster-Kronig transitions 3p-3d 2 (hole notation) and Coster-Kronig transitions 3p-3d 4s have been measured and compared with free-atom calculations for free Zn atoms. The experimental width GAMMA(3p)=(2.1+-0.2)eV found for the free atom agrees with the value obtained for solid Zn but is considerably smaller than the theoretical value for the free atom. Autoionizing spectra of Na following an L-shell excitation or ionization by different particles are compared and discussed. The nonisotropic angular distribution of electrons from the transition 2p 5 3s 2 2 Psub(3/2)→2p 6 +e - is compared with theoretical calculations. Two examples for Auger spectrometry of multiply ionized atoms are given: (1) excitation of neon target atoms by light and heavy ions, and (2) excitation of projectile ions Be + and B + in single gas collisions with CH 4 . A strong alignment of the excited atoms has also been found here

  2. A Decomposition Algorithm for Mean-Variance Economic Model Predictive Control of Stochastic Linear Systems

    DEFF Research Database (Denmark)

    Sokoler, Leo Emil; Dammann, Bernd; Madsen, Henrik

    2014-01-01

    This paper presents a decomposition algorithm for solving the optimal control problem (OCP) that arises in Mean-Variance Economic Model Predictive Control of stochastic linear systems. The algorithm applies the alternating direction method of multipliers to a reformulation of the OCP that decompo......This paper presents a decomposition algorithm for solving the optimal control problem (OCP) that arises in Mean-Variance Economic Model Predictive Control of stochastic linear systems. The algorithm applies the alternating direction method of multipliers to a reformulation of the OCP...

  3. Automated alarm to detect antigen excess in serum free immunoglobulin light chain kappa and lambda assays.

    Science.gov (United States)

    Urdal, Petter; Amundsen, Erik K; Toska, Karin; Klingenberg, Olav

    2014-10-01

    Antigen excess causing a falsely low concentration result may occur when measuring serum free immunoglobulin light chains (SFLC). Automated antigen excess detection methods are available only with some analyzers. We have now developed and verified such a method. Residuals of sera with known SFLC-κ and -λ concentrations were analyzed using Binding Site reagents and methods adapted to the Roche Cobas® c.501 analyzer. We analyzed 117 sera for SFLC-κ and -λ and examined how the absorbance increased with time during the 7 minutes of reaction (absorbance reading points 12-70). From this an antigen excess alarm factor (ratio of absorbance increases between reading points 68-60 and 20-12, multiplied by 100) was defined. Upon our request, Roche added to our two SFLC assays a program which calculated this antigen excess alarm factor and triggered an alarm when the factor was below a defined value. We verified this antigen excess alarm function by analyzing serum from 325 persons of whom 143 were multiple myeloma patients. All samples with a known concentration above 30 mg/L triggered either an antigen excess alarm, an 'above test' alarm or both. Also, all samples above 200 mg/L (SFLC-λ) and 300 mg/L (SFLC-κ) triggered the antigen excess alarm and all but one triggered the above test alarm. The antigen excess alarm function presented here detected all known antigen excess samples at no increased time of analysis, a reduced workload and reduced reagent cost.

  4. Carcinoembryonic antigen (CEA)

    International Nuclear Information System (INIS)

    Ephraim, K.H.; Cox, P.H.; Hamer, C.J.A. v.d.; Berends, W.; Delhez, H.

    1977-01-01

    The carcinoembryonic antigen (CEA) is a complex of antigen determinants and also the carrier of these determinants. Chemically it is a glycoprotein. Its occurrence in blood serum or urine is correlated with malignant disease. Several radioimmunoassays (RIA) have been developed, one by Hoffmann-Laroche and one by the Rotterdam Radiotherapeutic Institute. Both methods and the Hoffmann assay kit are tested. Specifications are given for isolation of the antigen, preparation of the antiserum, and the execution of the RIA. Biochemical and clinical aspects are discussed

  5. Deflation Expectation Financial System and Decline in Money Multiplier(in Japanese)

    OpenAIRE

    IIDA Yasuyuki

    2005-01-01

    The money multiplier is in a continuous downward trend now since the bubble burst, and, in addition, the trend has accelerated after 2000. It is said that the monetary policy is difficult because the money multiplier has declined. To think about the monetary policy for the future, we should think about the cause of the decline of the money multiplier. I want to verify two typical hypotheses "Deflation Expectation Hypothesis" and "Financial System Hypothesis" for the decision of the money mult...

  6. Extended generalized Lagrangian multipliers for magnetohydrodynamics using adaptive multiresolution methods

    Directory of Open Access Journals (Sweden)

    Domingues M. O.

    2013-12-01

    Full Text Available We present a new adaptive multiresoltion method for the numerical simulation of ideal magnetohydrodynamics. The governing equations, i.e., the compressible Euler equations coupled with the Maxwell equations are discretized using a finite volume scheme on a two-dimensional Cartesian mesh. Adaptivity in space is obtained via Harten’s cell average multiresolution analysis, which allows the reliable introduction of a locally refined mesh while controlling the error. The explicit time discretization uses a compact Runge–Kutta method for local time stepping and an embedded Runge-Kutta scheme for automatic time step control. An extended generalized Lagrangian multiplier approach with the mixed hyperbolic-parabolic correction type is used to control the incompressibility of the magnetic field. Applications to a two-dimensional problem illustrate the properties of the method. Memory savings and numerical divergences of magnetic field are reported and the accuracy of the adaptive computations is assessed by comparing with the available exact solution.

  7. Antiproton beam profile measurements using Gas Electron Multipliers

    CERN Document Server

    Duarte Pinto, Serge; Spanggaard, Jens; Tranquille, Gerard

    2011-01-01

    The new beam profile measurement for the Antiproton Decelerator (AD) at CERN is based on a single Gas Electron Multiplier (GEM) with a 2D readout structure. This detector is very light, ~0.4% X_0, as required by the low energy of the antiprotons, 5.3 MeV. This overcomes the problems previously encountered with multi-wire proportional chambers (MWPC) for the same purpose, where beam interactions with the detector severely affect the obtained profiles. A prototype was installed and successfully tested in late 2010, with another five detectors now installed in the ASACUSA and AEgIS beam lines. We will provide a detailed description of the detector and discuss the results obtained. The success of these detectors in the AD makes GEM-based detectors likely candidates for upgrade of the beam profile monitors in all experimental areas at CERN. The various types of MWPC currently in use are aging and becoming increasingly difficult to maintain.

  8. [A novel voltage multiplier for X-ray power supply].

    Science.gov (United States)

    Tang, Zhide; Yang, Hong; Wang, Guantao; Zhang, Zhengmao

    2011-10-01

    In this paper, a seriesly connected three phase bipolar symmetrical voltage multiplier (VM) is proposed, which is a novel VM for X-ray power supply. It consists of three single phase bipolar symmetrical VM, which are connected in series at their smoothing columns. The charging and discharging process occurs six times in a cycle and the frequency of the output voltage ripple is six times as large as the drive signal frequency. The proposed VM has three times larger output voltage and three times smaller ripple factor as compared to single phase bipolar symmetrical VM, and smaller voltage drop and faster dynamic response than those of the series connected three phase symmetrical VM. The simulation is provided to show the feasibility of proposed VM.

  9. Further developments of the gas electron multiplier (GEM)

    CERN Document Server

    Benlloch, J M; Capéans-Garrido, M; Gruwé, M; Hoch, M; Labbé, J C; Placci, Alfredo; Ropelewski, Leszek; Sauli, Fabio

    1998-01-01

    We describe the development and operation of the Gas Electron Multiplier, a thin insulating foil metal-clad on both sides and perforated by a regular pattern of small holes. The mesh can be incorporat ed in the gas volume of an active detector to provide a first amplification channel for electrons, or used as stand alone. We report on the basic properties of GEMs manufactured with different geometr ies and operated in several gas mixtures as well as on their long-term stability after accumulation of charge equivalent to several years of operation in high luminosity experiments. Optimized GEMs re ach gains close to 10000 at safe operating voltages, permitting the detection of ionizing tracks, without other amplifying elements, on a simple printed circuit board (PCB), opening new possibilities for detector design.

  10. Proximity effects in cold gases of multiply charged atoms (Review)

    Science.gov (United States)

    Chikina, I.; Shikin, V.

    2016-07-01

    Possible proximity effects in gases of cold, multiply charged atoms are discussed. Here we deal with rarefied gases with densities nd of multiply charged (Z ≫ 1) atoms at low temperatures in the well-known Thomas-Fermi (TF) approximation, which can be used to evaluate the statistical properties of single atoms. In order to retain the advantages of the TF formalism, which is successful for symmetric problems, the external boundary conditions accounting for the finiteness of the density of atoms (donors), nd ≠ 0, are also symmetrized (using a spherical Wigner-Seitz cell) and formulated in a standard way that conserves the total charge within the cell. The model shows that at zero temperature in a rarefied gas of multiply charged atoms there is an effective long-range interaction Eproxi(nd), the sign of which depends on the properties of the outer shells of individual atoms. The long-range character of the interaction Eproxi is evaluated by comparing it with the properties of the well-known London dispersive attraction ELond(nd) 0 and for the alkali and alkaline-earth elements Eproxi theory through the temperature dependence of the different versions of Eproxi. The anomaly in the thermal proximity effect shows up in the following way: for T ≠ 0 there is no equilibrium solution of TS statistics for single multiply charged atoms in a vacuum when the effect is present. Instability is suppressed in a Wigner-Seitz model under the assumption that there are no electron fluxes through the outer boundary R3 ∝ n-1d of a Wigner-Seitz cell. Eproxi corresponds to the definition of the correlation energy in a gas of interacting particles. This review is written so as to enable comparison of the results of the TF formalism with the standard assumptions of the correlation theory for classical plasmas. The classic example from work on weak solutions (including charged solutions)—the use of semi-impermeable membranes for studies of osmotic pressure—is highly appropriate for

  11. Development of a micro-array-type electron multiplier

    CERN Document Server

    Fukuda, D; Takahashi, H; Nakazawa, M; Kawarabayashi, J; Hirata, Y; Numazawa, T; Haga, T

    1999-01-01

    This paper describes the development of a micro-array-type electron multiplier (MAEM) and its application to preamplification of a hybrid photo diode (HPD) system. The MAEM consists of several dynode plates fabricated by micromachining techniques. In our simulation of the electron multiplication process in the HPD system, 4500 gain is easily obtained with the total voltage of 6 kV. No spread of electron charges into the neighboring channels is observed in the MAEM device. Consequently, very high position resolution can be achieved if the pixel-type PD is used with the MAEM. The simulation also showed small fluctuation of the electron transit time of 23 ps in the MAEM, thus very high timing resolution can be achieved.

  12. Development of a micro-array-type electron multiplier

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, D. E-mail: fukuda@sophie.q.t.u-tokyo.ac.jp; Inoue, M.; Takahashi, H.; Nakazawa, M.; Kawarabayashi, J.; Hirata, Y.; Numazawa, T.; Haga, T

    1999-10-21

    This paper describes the development of a micro-array-type electron multiplier (MAEM) and its application to preamplification of a hybrid photo diode (HPD) system. The MAEM consists of several dynode plates fabricated by micromachining techniques. In our simulation of the electron multiplication process in the HPD system, 4500 gain is easily obtained with the total voltage of 6 kV. No spread of electron charges into the neighboring channels is observed in the MAEM device. Consequently, very high position resolution can be achieved if the pixel-type PD is used with the MAEM. The simulation also showed small fluctuation of the electron transit time of 23 ps in the MAEM, thus very high timing resolution can be achieved.

  13. Electromagnetic Radiation in Multiply Connected Robertson-Walker Cosmologies

    CERN Document Server

    Tomaschitz, R

    1993-01-01

    Maxwell's equations on a topologically nontrivial cosmological background are studied. The cosmology is locally determined by a Robertson-Walker line element, but the spacelike slices are open hyperbolic manifolds, whose topology and geometry may vary in time. In this context the spectral resolution of Maxwell's equations in terms of horospherical elementary waves generated at infinity of hyperbolic space is given. The wave fronts are orthogonal to bundles of unstable geodesic rays, and the eikonal of geometric optics appears just as the phase of the horospherical waves. This fact is used to attach to the unstable geodesic rays a quantum mechanical momentum. In doing so the quantized energy-momentum tensor of the radiation field is constructed in a geometrically and dynamically transparent way, without appealing to the intricacies of the second quantization. In particular Planck's radiation formula, and the bearing of the multiply connected topology on the fluctuations in the temperature of the background rad...

  14. Research on nonlinearity effect of secondary electron multiplier

    International Nuclear Information System (INIS)

    Wei Xingjian; Liao Junsheng; Deng Dachao; Yu Chunrong; Yuan Li

    2007-01-01

    The nonlinearity of secondary electron multiplier (SEM) of a thermal ionization mass spectrometer has been researched by using UTB-500 uranium isotope reference material and multi-collecting technique. The results show that the nonlinearity effect of SEM exists in the whole ion counting range, and there is an extreme point of the nonlinearity when the ion counting rate is about 20000 cps. The deviation between measured value of the extreme point and the reference value of the reference sample can be up to 3%, and the nonlinearity obeys logarithm linearity law on both sides of extreme point. A kind of mathematics model of nonlinearity calibration has been put forward. Using this model, the nonlinearity of SEM of TIMS can be calibrated. (authors)

  15. Charge-exchange collisions of multiply charged ions with atoms

    International Nuclear Information System (INIS)

    Grozdanov, T.P.; Janev, R.K.

    1978-01-01

    The problem of electron transfer between neutral atoms and multiply charged ions is considered at low and medium energies. It is assumed that a large number of final states are available for the electron transition so that the electron-capture process is treated as a tunnel effect caused by the strong attractive Coulomb field of the multicharged ions. The electron transition probability is obtained in a closed form using the modified-comparison-equation method to solve the Schroedinger equation. An approximately linear dependence of the one-electron transfer cross section on the charge of multicharged ion is found. Cross-section calculations of a number of charge-exchange reactions are performed

  16. Identifying fMRI Model Violations with Lagrange Multiplier Tests

    Science.gov (United States)

    Cassidy, Ben; Long, Christopher J; Rae, Caroline; Solo, Victor

    2013-01-01

    The standard modeling framework in Functional Magnetic Resonance Imaging (fMRI) is predicated on assumptions of linearity, time invariance and stationarity. These assumptions are rarely checked because doing so requires specialised software, although failure to do so can lead to bias and mistaken inference. Identifying model violations is an essential but largely neglected step in standard fMRI data analysis. Using Lagrange Multiplier testing methods we have developed simple and efficient procedures for detecting model violations such as non-linearity, non-stationarity and validity of the common Double Gamma specification for hemodynamic response. These procedures are computationally cheap and can easily be added to a conventional analysis. The test statistic is calculated at each voxel and displayed as a spatial anomaly map which shows regions where a model is violated. The methodology is illustrated with a large number of real data examples. PMID:22542665

  17. Lagrange multiplier for perishable inventory model considering warehouse capacity planning

    Science.gov (United States)

    Amran, Tiena Gustina; Fatima, Zenny

    2017-06-01

    This paper presented Lagrange Muktiplier approach for solving perishable raw material inventory planning considering warehouse capacity. A food company faced an issue of managing perishable raw materials and marinades which have limited shelf life. Another constraint to be considered was the capacity of the warehouse. Therefore, an inventory model considering shelf life and raw material warehouse capacity are needed in order to minimize the company's inventory cost. The inventory model implemented in this study was the adapted economic order quantity (EOQ) model which is optimized using Lagrange multiplier. The model and solution approach were applied to solve a case industry in a food manufacturer. The result showed that the total inventory cost decreased 2.42% after applying the proposed approach.

  18. Multiply charged ions from solid substances with the mVINIS Ion Source

    International Nuclear Information System (INIS)

    Dragani, I; Nedeljkovi, T; Jovovi, J; Siljegovic, M; Dobrosavljevic, A

    2007-01-01

    We have used the well known metal-ions-from-volatile-compounds (MIVOC) method at the mVINIS Ion Source to produce the multiply charged ion beams form solid substances. Based on this method the very intense and stable multiply charged ion beams of several solid substances having the high melting points were extracted. The ion yields and the spectra of multiply charged ion beams obtained from solid materials like Fe and Hf will be presented. We have utilized the multiply charged ion beams from solid substances to irradiate the polymers, fullerenes and glassy carbon at the low energy channel for modification of materials

  19. Fabrication of beryllide pebble as advanced neutron multiplier

    Energy Technology Data Exchange (ETDEWEB)

    Nakamichi, Masaru, E-mail: nakamichi.masaru@jaea.go.jp; Kim, Jae-Hwan

    2014-10-15

    Highlights: • A new beryllide granulation process that combined process with a plasma sintering method for electrode fabrication and a rotating electrode method (REM) for granulation was suggested. • The beryllide electrode fabrication process was investigated for mass production. • As optimized beryllide electrode indicated higher ductility and was sintered at a lower temperature for a shorter time. • It appears to be more able to not only withstand the thermal shock from arc-discharge during granulation but also produce beryllide pebbles on a large scale. • These optimization results can reduce the time for electrode fabrication by 40%, they suggest the possibility of great reductions in time and cost for mass production of beryllide pebbles. - Abstract: Fusion reactors require advanced neutron multipliers with great stability at high temperatures. Beryllium intermetallic compounds, called beryllides such as Be{sub 12}Ti, are the most promising materials for use as advanced neutron multipliers. However, few studies have been conducted on the development of mass production methods for beryllide pebbles. A granulation process for beryllide needs to have both low cost and high efficiency. To fabricate beryllide pebbles, a new granulation process is established in this research by combining a plasma sintering method for beryllide synthesis and a rotating electrode method using a plasma-sintered electrode for granulation. The fabrication process of the beryllide electrode is investigated and optimized for mass production. The optimized beryllide electrode exhibits higher ductility and can be sintered at a lower temperature for a shorter time, indicating that it is more suitable not only for withstanding the thermal shock from arc-discharge during granulation but also for producing the beryllide pebbles on a large scale. Accordingly, because these optimization results can reduce the time required for electrode fabrication by 40%, they suggest the possibility

  20. Design of multiplier-less sharp non-uniform cosine modulated filter banks for efficient channelizers in software defined radio

    Directory of Open Access Journals (Sweden)

    Shaeen Kalathil

    2016-03-01

    Full Text Available Forthcoming software defined radios require filter banks which satisfy stringent specifications efficiently with low implementation complexity. Cosine modulated filter banks (CMFB have simple and efficient design procedure. The different wireless standards have different channel spacing or bandwidths and hence demand non-uniform decomposition of subbands. The non-uniform CMFB can be obtained from a uniform CMFB in a simple and efficient approach by merging the adjacent channels of the uniform CMFB. Very narrow transition width filters with low complexity can be achieved using frequency response masking (FRM filter as prototype filter. The complexity is further reduced by the multiplier-less realization of filter banks in which the least number of signed power of two (SPT terms is achieved by representing the filter coefficients using canonic signed digit (CSD representation and then optimizing using suitable modified meta-heuristic algorithms. Hybrid meta-heuristic algorithms are used in this paper. A hybrid algorithm combines the qualities of two meta-heuristic algorithms and results in improved performances with low implementation complexity. Highly frequency selective filter banks characterized by small passband ripple, narrow transition width and high stopband attenuation with non-uniform decomposition of subbands can be designed with least the implementation complexity, using this approach. A digital channelizer can be designed for SDR implementations, using the proposed approach. In this paper, the non-uniform CMFB is designed for various existing wireless standards.

  1. Lidar returns from multiply scattering media in multiple-field-of-view and CCD lidars with polarization devices: comparison of semi-analytical solution and Monte Carlo data.

    Science.gov (United States)

    Chaikovskaya, Ludmila I; Zege, Eleonora P; Katsev, Iosif L; Hirschberger, Markus; Oppel, Ulrich G

    2009-01-20

    Quite recently, a semi-analytical approach to the sounding of multiply scattering media (clouds, seawaters) using multiple-field-of-view and CCD lidars with polarization devices was developed. The angular distributions of polarized components of the lidar returns from multiply scattering media computed on the basis of this theory using the small-angle approximation are presented and discussed. The semi-analytical nature of the solution makes the computation procedure faster. The obtained data are compared with results provided by the most advanced Monte Carlo algorithms for simulation of modern lidar performance. The good agreement between data provided by the semi-analytical approach and Monte Carlo computations assures one that these approaches can serve as a reliable theoretical base for interpretation and inversion of cloud lidar sounding data obtained with polarized lidars, including polarized multiple-field-of-view and CCD lidars.

  2. A Robust Algorithm to Determine the Topology of Space from the Cosmic Microwave Background Radiation

    OpenAIRE

    Weeks, Jeffrey R.

    2001-01-01

    Satellite measurements of the cosmic microwave back-ground radiation will soon provide an opportunity to test whether the universe is multiply connected. This paper presents a new algorithm for deducing the topology of the universe from the microwave background data. Unlike an older algorithm, the new algorithm gives the curvature of space and the radius of the last scattering surface as outputs, rather than requiring them as inputs. The new algorithm is also more tolerant of erro...

  3. On The Algorithm for Dynamic Restoring Control Problems with ...

    African Journals Online (AJOL)

    An algorithm is hereby developed to solve a class of control problems constrained by dynamic restoring type with matrix coefficients numerically. The penalty-multiplier method is evolved to obtain an unconstrained discretized formulation. With the bilinear form expression, an associated operator is constructed via a theorem ...

  4. Numerical Algorithm For Digital Image Enhancement And Noise ...

    African Journals Online (AJOL)

    We adopt the approach of Vogel and Oman, 1998 and introduce a Lagrange multiplier Ibiejugba, 1985, to obtain an appropriate discrete energy which we minimize, in order to minimize equivalently, the unwanted vibration (noise) associated with a digitally transmitted image. An iterative algorithm is developed for this ...

  5. Co-Occuring Directions Sketching for Approximate Matrix Multiply

    OpenAIRE

    Mroueh, Youssef; Marcheret, Etienne; Goel, Vaibhava

    2016-01-01

    We introduce co-occurring directions sketching, a deterministic algorithm for approximate matrix product (AMM), in the streaming model. We show that co-occuring directions achieves a better error bound for AMM than other randomized and deterministic approaches for AMM. Co-occurring directions gives a $1 + \\epsilon$ -approximation of the optimal low rank approximation of a matrix product. Empirically our algorithm outperforms competing methods for AMM, for a small sketch size. We validate empi...

  6. Algorithmic cryptanalysis

    CERN Document Server

    Joux, Antoine

    2009-01-01

    Illustrating the power of algorithms, Algorithmic Cryptanalysis describes algorithmic methods with cryptographically relevant examples. Focusing on both private- and public-key cryptographic algorithms, it presents each algorithm either as a textual description, in pseudo-code, or in a C code program.Divided into three parts, the book begins with a short introduction to cryptography and a background chapter on elementary number theory and algebra. It then moves on to algorithms, with each chapter in this section dedicated to a single topic and often illustrated with simple cryptographic applic

  7. Jacobi's last multiplier and symmetries for the Kepler problem plus a lineal story

    International Nuclear Information System (INIS)

    Nucci, M C; Leach, P G L

    2004-01-01

    We calculate the first integrals of the Kepler problem by the method of Jacobi's last multiplier using the symmetries for the equations of motion. Also we provide another example which shows that Jacobi's last multiplier together with Lie symmetries unveils many first integrals neither necessarily algebraic nor rational whereas other published methods may yield just one

  8. Exponential decay and exponential recovery of modal gains in high count rate channel electron multipliers

    International Nuclear Information System (INIS)

    Hahn, S.F.; Burch, J.L.

    1980-01-01

    A series of data on high count rate channel electron multipliers revealed an initial drop and subsequent recovery of gains in exponential fashion. The FWHM of the pulse height distribution at the initial stage of testing can be used as a good criterion for the selection of operating bias voltage of the channel electron multiplier

  9. Investigation of the Decelerating Field of an Electron Multiplier under Negative Ion Impact

    DEFF Research Database (Denmark)

    Larsen, Elfinn; Kjeldgaard, K.

    1973-01-01

    The effect of the decelerating field of an electron multiplier towards negative ions was investigated under standard mass spectrometric conditions. Diminishing of this decelerating field by changing of the potential of the electron multiplier increased the overall sensitivity to negative ions...

  10. A Nodes Deployment Algorithm in Wireless Sensor Network Based on Distribution

    Directory of Open Access Journals (Sweden)

    Song Yuli

    2014-07-01

    Full Text Available Wireless sensor network coverage is a basic problem of wireless sensor network. In this paper, we propose a wireless sensor network node deployment algorithm base on distribution in order to form an efficient wireless sensor network. The iteratively greedy algorithm is used in this paper to choose priority nodes into active until the entire network is covered by wireless sensor nodes, the whole network to multiply connected. The simulation results show that the distributed wireless sensor network node deployment algorithm can form a multiply connected wireless sensor network.

  11. On-Chip Power-Combining for High-Power Schottky Diode Based Frequency Multipliers

    Science.gov (United States)

    Siles Perez, Jose Vicente (Inventor); Chattopadhyay, Goutam (Inventor); Lee, Choonsup (Inventor); Schlecht, Erich T. (Inventor); Jung-Kubiak, Cecile D. (Inventor); Mehdi, Imran (Inventor)

    2015-01-01

    A novel MMIC on-chip power-combined frequency multiplier device and a method of fabricating the same, comprising two or more multiplying structures integrated on a single chip, wherein each of the integrated multiplying structures are electrically identical and each of the multiplying structures include one input antenna (E-probe) for receiving an input signal in the millimeter-wave, submillimeter-wave or terahertz frequency range inputted on the chip, a stripline based input matching network electrically connecting the input antennas to two or more Schottky diodes in a balanced configuration, two or more Schottky diodes that are used as nonlinear semiconductor devices to generate harmonics out of the input signal and produce the multiplied output signal, stripline based output matching networks for transmitting the output signal from the Schottky diodes to an output antenna, and an output antenna (E-probe) for transmitting the output signal off the chip into the output waveguide transmission line.

  12. Algorithmic mathematics

    CERN Document Server

    Hougardy, Stefan

    2016-01-01

    Algorithms play an increasingly important role in nearly all fields of mathematics. This book allows readers to develop basic mathematical abilities, in particular those concerning the design and analysis of algorithms as well as their implementation. It presents not only fundamental algorithms like the sieve of Eratosthenes, the Euclidean algorithm, sorting algorithms, algorithms on graphs, and Gaussian elimination, but also discusses elementary data structures, basic graph theory, and numerical questions. In addition, it provides an introduction to programming and demonstrates in detail how to implement algorithms in C++. This textbook is suitable for students who are new to the subject and covers a basic mathematical lecture course, complementing traditional courses on analysis and linear algebra. Both authors have given this "Algorithmic Mathematics" course at the University of Bonn several times in recent years.

  13. Kinetics of HBsub(s) antigen in man

    International Nuclear Information System (INIS)

    Drouet, J.; Courouce-Pauty, A.M.; Thevenoux, A.M.; Soulier, J.P.; Chanard, J.; Vallee, G.; Funck-Brentano, J.L.

    1975-01-01

    The metabolism of HBsub(s) antigen had been studied in three human volunteers. One had chronic hepatitis and two were silent carriers. The HBsub(s) antigen had been isolated and purified from the plasma of each of the three subjects and, after iodination, reinjected to the same donor. The parameters of plasma kinetics of 131 I HBsub(s)Ag have been analyzed according to a two compartmental model on the basis of the radioactivity of TCA precipitate (TP) and immunoprecipitate (IP). The fast initial volume of distribution was approximately equal in the three subjects (46.6ml/kg). The metabolic clearance rate (MCR) of IP was the very same in two subjects but is four times higher in one of the silent carrier. The total renewal time (TRT) was about 3.3 days. Assuming that the HBsub(s) antigen extraction was of the order of 65% the plasma HBsub(s) antigen concentration per liter of plasma would be 12 and 53mg/liter for two silent carriers and 61 mg/liter for the patient with chronic hepatitis. The radioactive efflux from the model (calculated as IP.MCR multiplied by HBsub(s) antigen concentration) was identical for the two silent carriers and 50% higher in the patient with chronic hepatitis. The increase possibly reflects an increased synthesis of HBsub(s) antigen in the patient with chronic hepatitis. The cumulative urinary radioactivity when added to the whole body counting demonstrated that radioactivity was excreted solely in the urine. The ratio of organ counting to precordium counting did not vary significantly with time in all subjects [fr

  14. Specification of the Fast Fourier Transform algorithm as a term rewriting system

    NARCIS (Netherlands)

    Rodenburg, P.H.; Hoekzema, D.J.

    1987-01-01

    We specify an algorithm for multiplying polynomials with complex coefficients incorporating, the Fast Fourier Transform algorithm of Cooley and Tukey [CT]. The specification formalism we use is a variant of the formalism ASF described in. [BHK]. The difference with ASF is essentially a matter of

  15. Time-division-multiplex control scheme for voltage multiplier rectifiers

    Directory of Open Access Journals (Sweden)

    Bin-Han Liu

    2017-03-01

    Full Text Available A voltage multiplier rectifier with a novel time-division-multiplexing (TDM control scheme for high step-up converters is proposed in this study. In the proposed TDM control scheme, two full-wave voltage doubler rectifiers can be combined to realise a voltage quadrupler rectifier. The proposed voltage quadrupler rectifier can reduce transformer turn ratio and transformer size for high step-up converters and also reduce voltage stress for the output capacitors and rectifier diodes. An N-times voltage rectifier can be straightforwardly produced by extending the concepts from the proposed TDM control scheme. A phase-shift full-bridge (PSFB converter is adopted in the primary side of the proposed voltage quadrupler rectifier to construct a PSFB quadrupler converter. Experimental results for the PSFB quadrupler converter demonstrate the performance of the proposed TDM control scheme for voltage quadrupler rectifiers. An 8-times voltage rectifier is simulated to determine the validity of extending the proposed TDM control scheme to realise an N-times voltage rectifier. Experimental and simulation results show that the proposed TDM control scheme has great potential to be used in high step-up converters.

  16. Upgrading PhotoMultiplier Tube bases for FNAL E1039

    Science.gov (United States)

    Salinas, Roy; SeaQuest Collaboration

    2017-09-01

    Experiment 1039 at Fermilab National Laboratory is designed to study the spin structure within the nucleon. To effectively work towards a better understanding of the ``spin crisis'' concerning the quarks and gluons within the nucleon, E1039 will employ a polarized target and a 120 GeV proton beam. The E906/SeaQuest spectrometer will be reused for E1039 since it was designed to measure Drell-Yan events from interactions with quarks in the nucleon sea. The spectrometer consists of several detectors with multiple planes of scintillating hodoscopes, tracking chambers, and two large dipole magnets. An issue arose in the later stages of Experiment 906 regarding the scintillating PhotoMultiplier Tubes(PMTs) high current bases for the first two hodoscope stations. Heat produced in the PMT bases created damage to components on the primary circuit board resulting in failures after years of running. Multiple solutions focused on thermally connecting the daughter cards to the metal shielding pipe while also providing electrical isolation of the high voltages present. Comparisons of thermally conductive adhesive and epoxy were studied with several heat spreaders. This poster will cover the options considered and the chosen solution to the upgrade to the hodoscope PMT bases. Supported by U.S. D.O.E. Medium Energy Nuclear Physics under Grant DE-FG02-03ER41243.

  17. A Novel and Efficient Hardware Implementation of Scalar Point Multiplier

    Directory of Open Access Journals (Sweden)

    M. Masoumi

    2012-12-01

    Full Text Available A new and highly efficient architecture for elliptic curve scalar point multiplication is presented. To achieve the maximum architectural and timing improvements we have reorganized and reordered the critical path of the Lopez-Dahab scalar point multiplication architecture such that logic structures are implemented in parallel and operations in the critical path are diverted to noncritical paths. The results we obtained show that with G = 55 our proposed design is able to compute GF(2163 elliptic curve scalar multiplication in 9.6 μs with the maximum achievable frequency of 250 MHz on Xilinx Virtex-4 (XC4VLX200, where G is the digit size of the underlying digit-serial finite field multiplier. Another implementation variant for less resource consumption is also proposed. With G=33, the design performs the same operation in 11.6 μs at 263 MHz on the same platform. The results of synthesis show that in the first implementation 17929 slices or 20% of the chip area is occupied which makes it suitable for speed critical cryptographic applications while in the second implementation 14203 slices or 16% of the chip area is utilized which makes it suitable for applications that may require speed-area trade-off. The new design shows superior performance compared to the previously reported designs.

  18. Multiply charged metal ions in high current pulsed vacuum arcs

    Science.gov (United States)

    Yushkov, G. Yu.; Nikolaev, A. G.; Frolova, V. P.; Oks, E. M.; Rousskikh, A. G.; Zhigalin, A. S.

    2017-12-01

    We show that vacuum arc plasma discharges with a current of several kiloamperes and duration of a few microseconds can generate multiply charged metal ions with charge states greater than 10+. The physical mechanism behind this is discussed, suggesting an optimum arc current for higher charge states depending on the pulse duration and cathode material. Measurements of ion mass-to-charge ratio and images taken with nanosecond resolution suggest that, higher charge state ions are produced at characteristic distances of ˜10 mm from the cathode as the arc current peaks, and the process responsible for their generation is additional ionization as the discharge is pinched by its self-magnetic field. The maximum and mean ion charge states reveal a considerable increase for the all cathode materials studied: magnesium, aluminum, zirconium, tin, tantalum, gold, lead, and bismuth. For bismuth ions, the maximum charge state reaches a record-breaking value of 17+ and the mean of the charge state distribution is 12.6+. The results obtained are of interest for vacuum arc discharge physics and for ion beam technologies.

  19. Environmental education activities in Rondon Project: a strategy transformation multiplier

    Directory of Open Access Journals (Sweden)

    Milina Oliveira

    2017-11-01

    Full Text Available The proposal of the "Amazon portal" through the Rondon project consisted of expository workshops in the period from 27 January to 09 February 2014. The proposal was implemented at Dom Bosco Catholic University (UCDB, who was served by a teacher and three academic area of Sanitary and Environmental Engineering. This article describes an experience report lived in the municipality of Tocantinópolis - TO / Brazil, through academic extension with context that brings academic and practical application of knowledge, adding new human values and aimed to improve the living conditions and the training of multipliers. The action had as a result the interaction of the community where activities have been implemented, both for young students in the city, and for indigenous, steadying the project commitment in terms of a sustainable youth, promoting this improvement in the formation of academics and favors the exercise of social commitment. Interactions such as occur during the Rondon Project makes every worker reflects on their education, not only as a professional, but certainly as a citizen.

  20. Total algorithms

    NARCIS (Netherlands)

    Tel, G.

    We define the notion of total algorithms for networks of processes. A total algorithm enforces that a "decision" is taken by a subset of the processes, and that participation of all processes is required to reach this decision. Total algorithms are an important building block in the design of

  1. A monkey antigen crossreacting with carcinoembryonic antigen, CEA.

    Science.gov (United States)

    Engvall, E.; Vuento, M.; Ruoslahti, E.

    1976-01-01

    Normal monkey tissues were found to contain an antigen which crossreacts immunologically with the carcinoembryonic antigen (CEA) of the human digestive tract. The monkey antigen reacted with complete or partial identity to the normal crossreacting antigen (NCA) in humans when tested in immunodiffusion against anti-CEA or anti-NCA. Extracts of monkey tissues inhibited in radioimmunoassays measuring human NCA. It is possible that monkey foetuses and colonic tumours contain CEA. Images Fig. 1 PMID:823952

  2. Antigen smuggling in tuberculosis.

    Science.gov (United States)

    Hudrisier, Denis; Neyrolles, Olivier

    2014-06-11

    The importance of CD4 T lymphocytes in immunity to M. tuberculosis is well established; however, how dendritic cells activate T cells in vivo remains obscure. In this issue of Cell Host & Microbe, Srivastava and Ernst (2014) report a mechanism of antigen transfer for efficient activation of antimycobacterial T cells. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 58, č. 6 (2001), s. 425-430 ISSN 0001-2815. [Conference on Human leucocyte differentiation antigens /7./. Harrogate, 20.06.2000-25.06.2000] Institutional research plan: CEZ:AV0Z5052915 Keywords : CD molecules, HLDA Subject RIV: EC - Immunology Impact factor: 2.864, year: 2001

  4. CD antigens 2002

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2002-01-01

    Roč. 99, č. 10 (2002), s. 3877-3880 ISSN 0006-4971. [Conference on Human leucocyte differentiation antigens /7./. Harrogate, 20.06.2000-25.06.2000] Institutional research plan: CEZ:AV0Z5052915 Keywords : CD molecules, HLDA Subject RIV: EC - Immunology Impact factor: 9.631, year: 2002

  5. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2002-01-01

    Roč. 168, č. 5 (2002), s. 2083-2086 ISSN 0022-1767. [Conference on Human leucocyte differentiation antigens /7./. Harrogate, 20.06.2000-25.06.2000] Institutional research plan: CEZ:AV0Z5052915 Keywords : CD molecules, HLDA Subject RIV: EC - Immunology Impact factor: 7.014, year: 2002

  6. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 103, č. 4 (2001), s. 401-406 ISSN 0019-2805 R&D Projects: GA ČR GA310/99/0349 Institutional research plan: CEZ:AV0Z5052915 Keywords : antigen * CD * leukocyte Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.656, year: 2001

  7. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 19, č. 6 (2001), s. 556-562 ISSN 1066-5099 R&D Projects: GA AV ČR IAA7052904 Institutional research plan: CEZ:AV0Z5052915 Keywords : CD * leukocyte antigens Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.689, year: 2001

  8. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 31, č. 10 (2001), s. 2841-2847 ISSN 0014-2980 R&D Projects: GA AV ČR IAA7052904 Keywords : CD * leukocyte antigens Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.990, year: 2001

  9. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 211, č. 2 (2001), s. 81-85 ISSN 0008-8749 R&D Projects: GA ČR GA310/99/0349 Institutional research plan: CEZ:AV0Z5052915 Keywords : antigen * CD * leukocyte Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.604, year: 2001

  10. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2002-01-01

    Roč. 15, č. 1 (2002), s. 71-76 ISSN 0893-3952. [Conference on Human leucocyte differentiation antigens /7./. Harrogate, 20.06.2000-25.06.2000] Institutional research plan: CEZ:AV0Z5052915 Keywords : CD molecules, HLDA Subject RIV: EC - Immunology Impact factor: 3.821, year: 2002

  11. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 70, č. 5 (2001), s. 685-690 ISSN 0741-5400 R&D Projects: GA AV ČR IAA7052904 Institutional research plan: CEZ:AV0Z5052915 Keywords : CD * leukocyte antigens Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.516, year: 2001

  12. CD antigens 2001

    Czech Academy of Sciences Publication Activity Database

    Mason, D.; Andre, P.; Bensussan, A.; Buckley, C.; Civin, C.; Clark, E.; de Haas, M.; Goyert, S.; Hadam, M.; Hart, D.; Hořejší, Václav; Meuer, S.; Morrissey, J.; Schwartz-Albiez, R.; Shaw, S.; Simmons, D.; Uguccioni, M.; van der Schoot, E.; Vivier, E.; Zola, H.

    2001-01-01

    Roč. 13, č. 9 (2001), s. 1095-1098 ISSN 0953-8178 R&D Projects: GA ČR GA310/99/0349 Institutional research plan: CEZ:AV0Z5052915 Keywords : antigen * CD * leukocyte Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.611, year: 2001

  13. β-endorphin antigen

    International Nuclear Information System (INIS)

    1981-01-01

    This invention relates to the production of antigens comprising β-endorphin, βsub(h)-endorphin, or βsub(c)-endorphin, in covalent conjugation with human gammaglobulin as immunogenic carrier material, and an antibody having the property of specifically binding β-endorphin or fragments thereof, containing the (6-15) residue sequence. (U.K.)

  14. Alternating-direction method of multipliers estimation of attenuation and activity distributions in time-of-flight flat-panel positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Yueh; Chou, Cheng-Ying [National Taiwan University, Taipei, Taiwan (China)

    2015-05-18

    A quantitative reconstruction of radiotracer activity distribution in positron emission tomography (PET) requires correction of attenuation, which was typically estimated through transmission measurements. The advancement in hardware development has prompted the use of time-of-flight (TOF) to improve PET imaging. Recently, the application of TOF-PET has been further extended to obtain attenuation map in addition to activity distribution simultaneously by use of iterative algorithms. Two flat-panel detectors are employed thus many transaxial lines of response are not detected. In this work, we applied the alternating-direction method of multipliers (ADMM) to simultaneously reconstruct TOF-PET and attenuation estimation in a dualhead small-animal PET system. The results were compared with those obtained by use of the maximum-likelihood algorithm. The computer simulation results showed that the application of the ADMM algorithm could greatly improve the image quality and reduce noisy appearance.

  15. Analysis of multiplier effects of ICT sectors – a Croatian case

    Directory of Open Access Journals (Sweden)

    Damira Keček

    2016-04-01

    Full Text Available The impact of Information and Communication Technology (ICT on economic growth and development has nowadays proven to be significant for almost all national economies. In this paper, a quantitative analysis of the impact of ICT on Croatian economic growth is performed using the input-output (IO method. The direct and indirect effects of ICT sectors are analysed. Subsequently, simple output multipliers and simple value added multipliers are then calculated. The results indicate that there are no significant differences between the ICT multipliers for the Croatian economy in 2010 and multipliers of other sectors. The largest values of multipliers of all ICT sectors are attributed to the one of ICT service sector. Moreover, significant changes were also not observed when comparing ICT multipliers for the Croatian economy in 2004 and 2010. In addition to Croatia, multiplier analysis of ICT sectors was conducted for the group of new and long-standing European Union member states. The conclusion is that, in new member states, the implementation and usage of ICT has a lower contribution to economic growth and development.

  16. Effect of the equity multiplier indicator in companies according the sectors

    Directory of Open Access Journals (Sweden)

    Lenka Lízalová

    2013-01-01

    Full Text Available Managers carry out the demand of the owners to maximise the rentability of invested capital with regards to the taken risk. The tool that evaluates the suitability to indebt in order to reach a higher rentability is the equity multiplier indicator. An analysis of the multiplier was carried out on 10 years of data from 456 Czech companies. Based on the data from these companies the influence of two components of the multiplier, which characterise the influence of indebtedness on the return on equity, was analysed. These components are “financial leverage” and “interest burden”, these having an antagonistic effect. The low variability of the equity multiplier is apparent in the companies of the administrative and support service sector and it is also relatively low in the companies of the agriculture, forestry and fishing sector; on the contrary, in for example the professional, scientific and technical activities and the sector of water, sewage and waste there are companies with higher variability of the equity multiplier. The paper identifies companies (in view of their sector specialization inclining to a larger utility of debts to increase the return on equity. The largest equity is reached in companies of the construction sector; the lowest effect of the multiplier is to be found in companies of the agriculture sector. The resulting value of the multiplier is to a large extent determined by the financial leverage indicator, to a lower extent and at the same time negatively by the interest burden indicator.

  17. The Origins of the SPAR-H Method's Performance Shaping Factor Multipliers

    Energy Technology Data Exchange (ETDEWEB)

    Ronald L. Boring; Harold S. Blackman

    2007-08-01

    The Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method has proved to be a reliable, easy-to-use method for human reliability analysis. Calculation of human error probability (HEP) rates is especially straightforward, starting with pre-defined nominal error rates for cognitive vs. action oriented tasks, and incorporating performance shaping factor (PSF) multipliers upon those nominal error rates. SPAR-H uses eight PSFs with multipliers typically corresponding to nominal, degraded, and severely degraded human performance for individual PSFs. Additionally, some PSFs feature multipliers to reflect enhanced performance. Although SPAR-H enjoys widespread use among industry and regulators, current source documents on SPAR-H such as NUREG/CR-6883 do not provide a clear account of the origin of these multipliers. The present paper redresses this shortcoming and documents the historic development of the SPAR-H PSF multipliers, from the initial use of nominal error rates, to the selection of the eight PSFs, to the mapping of multipliers to available data sources such as a Technique for Human Error Rate Prediction (THERP). Where error rates were not readily derived from THERP and other sources, expert judgment was used to extrapolate appropriate values. In documenting key background information on the multipliers, this paper provides a much needed cross-reference for human reliability practitioners and researchers of SPAR-H to validate analyses and research findings.

  18. Confinement of multiply charged ions in an ECRH mirror plasma

    International Nuclear Information System (INIS)

    Petty, C.C.

    1989-06-01

    This thesis is an experimental study of multiply charged ions in the Constance B mirror experiment. By measuring the ion densities, end loss fluxes and ion temperatures, the parallel confinement times for the first five charge states of oxygen and neon plasmas are determined. The parallel ion confinement times increase with charge state and peak on axis, both indications of an ion-confining potential dip created by the hot electrons. The radial profile of ion end loss is usually hollow due to large ion radial transport (τ paralleli ∼ τ perpendiculari ), with the peak fluxes occurring at the edge of the electron cyclotron resonance zone. Several attempts are made to increase the end loss of selected ion species. Using minority ICRH, the end loss flux of resonant ions increases by 20% in cases when radial transport induced by ICRH is not too severe. A large antenna voltage can also extinguish the plasma. By adding helium to an oxygen plasma, the end loss of O 6+ increases by 80% due to decreased ion radial transport. An ion model is developed to predict the ion densities, end loss fluxes and confinement times in the plasma center using the ion particle balance equations, the quasineutrality condition and theoretical confinement time formulas. The model generally agrees with the experimental data for oxygen and neon plasmas to within experimental error. Under certain conditions spatial diffusion appears to determine the parallel ion confinement time of the highest charge states. For oxygen plasmas during ICRH, the measured parallel confinement time of the resonant ions is much shorter than their theoretical value, probably due to rf diffusion of the ions into the loss cone. 58 refs., 101 figs., 16 tabs

  19. Permeability criteria for effective function of passive countercurrent multiplier.

    Science.gov (United States)

    Layton, H E; Knepper, M A; Chou, C L

    1996-01-01

    The urine concentrating effect of the mammalian renal inner medulla has been attributed to countercurrent multiplication of a transepithelial osmotic difference arising from passive absorption of NaCl from thin ascending limbs of long loops of Henle. This study assesses, both mathematically and experimentally, whether the permeability criteria for effective function of this passive hypothesis are consistent with transport properties measured in long loops of Henle of chinchilla. Mathematical simulations incorporating loop of Henle transepithelial permeabilities idealized for the passive hypothesis generated a steep inner medullary osmotic gradient, confirming the fundamental feasibility of the passive hypothesis. However, when permeabilities measured in chinchilla were used, no inner medullary gradient was generated. A key parameter in the apparent failure of the passive hypothesis is the long-loop descending limb (LDL) urea permeability, which must be small to prevent significant transepithelial urea flux into inner medullary LDL. Consequently, experiments in isolated perfused thin LDL were conducted to determine whether the urea permeability may be lower under conditions more nearly resembling those in the inner medulla. LDL segments were dissected from 30-70% of the distance along the inner medullary axis of the chinchilla kidney. The factors tested were NaCl concentration (125-400 mM in perfusate and bath), urea concentration (5-500 mM in perfusate and bath), calcium concentration (2-8 mM in perfusate and bath), and protamine concentration (300 micrograms/ml in perfusate). None of these factors significantly altered the measured urea permeability, which exceeded 20 x 10(-5) cm/s for all conditions. Simulation results show that this moderately high urea permeability in LDL is an order of magnitude too high for effective operation of the passive countercurrent multiplier.

  20. Configurable multiplier modules for an adaptive computing system

    Directory of Open Access Journals (Sweden)

    O. A. Pfänder

    2006-01-01

    Full Text Available The importance of reconfigurable hardware is increasing steadily. For example, the primary approach of using adaptive systems based on programmable gate arrays and configurable routing resources has gone mainstream and high-performance programmable logic devices are rivaling traditional application-specific hardwired integrated circuits. Also, the idea of moving from the 2-D domain into a 3-D design which stacks several active layers above each other is gaining momentum in research and industry, to cope with the demand for smaller devices with a higher scale of integration. However, optimized arithmetic blocks in course-grain reconfigurable arrays as well as field-programmable architectures still play an important role. In countless digital systems and signal processing applications, the multiplication is one of the critical challenges, where in many cases a trade-off between area usage and data throughput has to be made. But the a priori choice of word-length and number representation can also be replaced by a dynamic choice at run-time, in order to improve flexibility, area efficiency and the level of parallelism in computation. In this contribution, we look at an adaptive computing system called 3-D-SoftChip to point out what parameters are crucial to implement flexible multiplier blocks into optimized elements for accelerated processing. The 3-D-SoftChip architecture uses a novel approach to 3-dimensional integration based on flip-chip bonding with indium bumps. The modular construction, the introduction of interfaces to realize the exchange of intermediate data, and the reconfigurable sign handling approach will be explained, as well as a beneficial way to handle and distribute the numerous required control signals.

  1. A method for calculating minimum biodiversity offset multipliers accounting for time discounting, additionality and permanence.

    Science.gov (United States)

    Laitila, Jussi; Moilanen, Atte; Pouzols, Federico M

    2014-11-01

    Biodiversity offsetting, which means compensation for ecological and environmental damage caused by development activity, has recently been gaining strong political support around the world. One common criticism levelled at offsets is that they exchange certain and almost immediate losses for uncertain future gains. In the case of restoration offsets, gains may be realized after a time delay of decades, and with considerable uncertainty. Here we focus on offset multipliers, which are ratios between damaged and compensated amounts (areas) of biodiversity. Multipliers have the attraction of being an easily understandable way of deciding the amount of offsetting needed. On the other hand, exact values of multipliers are very difficult to compute in practice if at all possible. We introduce a mathematical method for deriving minimum levels for offset multipliers under the assumption that offsetting gains must compensate for the losses (no net loss offsetting). We calculate absolute minimum multipliers that arise from time discounting and delayed emergence of offsetting gains for a one-dimensional measure of biodiversity. Despite the highly simplified model, we show that even the absolute minimum multipliers may easily be quite large, in the order of dozens, and theoretically arbitrarily large, contradicting the relatively low multipliers found in literature and in practice. While our results inform policy makers about realistic minimal offsetting requirements, they also challenge many current policies and show the importance of rigorous models for computing (minimum) offset multipliers. The strength of the presented method is that it requires minimal underlying information. We include a supplementary spreadsheet tool for calculating multipliers to facilitate application.

  2. Evaluation of HIV antigen /antibody combination ELISAs for ...

    African Journals Online (AJOL)

    Abstract. Introduction: the aim of this study was to evaluate the performance of Enzygnost HIV Integral II antigen/antibody combination ELISAs in order to formulate HIV ELISA testing algorithms for the Ministry of Health and Social Welfare, Tanzania. Methods: this was a laboratory-based evaluation of Enzygnost HIV Integral ...

  3. Effect of the channel electron multiplier connection diagram on its parameters

    International Nuclear Information System (INIS)

    Ajnbund, M.R.

    1976-01-01

    Basic alternatives of connection of a channel electron multiplier are described. A dependence of a gain factor and amplitude resolution of the channel electron multiplier upon its connection diagram is studied. The studies have shown that the maximum gain factor is typical of an open-output circuit where the signal is recorded from the anode of the channel electron multiplier at a potential with respect to the channel outlet. The highest amplitude resolution is inherent in a separate-anode circuit where the loading resistance is connected directly to the channel outlet

  4. CORDIC TECHNIQUES FOR FIXED ANGLE OF ROTATION IN MULTIPLYING OPERATION OF QUATERNIONS

    Directory of Open Access Journals (Sweden)

    N. A. Petrovsky

    2015-01-01

    Full Text Available The article contains a number of solutions for the key element of paraunitary filter banks based on quaternionic algebra (Q-PUBF – the multiplier of quaternions with usage of CORDIC (Coordinate Rotation Digital Computer techniques for the fixed angle of rotation where, unlike known solutions, 4D rotation control parameters are represented by nonlinear function of shifts number of input operands of the microrotation operation. Suggested approach of the multiplier designing on a quaternion-constant allows reaching the maximum performance of the multiplier scheme with low use of resources, for example, of FPGA.

  5. Computational methods of Gaussian Particle Swarm Optimization (GPSO) and Lagrange Multiplier on economic dispatch issues (case study on electrical system of Java-Bali IV area)

    Science.gov (United States)

    Komsiyah, S.

    2014-03-01

    The objective in this paper is about economic dispatch problem of electric power generation where scheduling the committed generating units outputs so as to meet the required load demand at minimum operating cost, while satisfying all units and system equality and inequality constraint. In the operating of electric power system, an economic planning problem is one of variables that its must be considered since economically planning will give more efficiency in operational cost. In this paper the economic dispatch problem which has non linear cost function solved by using swarm intelligent method is Gaussian Particle Swarm Optimization (GPSO) and Lagrange Multiplier. GPSO is a population-based stochastic algorithms which their moving inspired by swarm intelligent and probabilities theories. To analize its accuracy, the economic dispatch solution by GPSO method will be compared with Lagrange multiplier method. From the running test result the GPSO method give economically planning calculation which it better than Lagrange multiplier method and the GPSO method faster to getting error convergence. Therefore the GPSO method have better performance to getting global best solution than the Lagrange method.

  6. Human platelet antigens - 2013.

    Science.gov (United States)

    Curtis, B R; McFarland, J G

    2014-02-01

    To date, 33 human platelet alloantigens (HPAs) have been identified on six functionally important platelet glycoprotein (GP) complexes and have been implicated in alloimmune platelet disorders including foetal and neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura (PTP) and multitransfusion platelet refractoriness (MPR). The greatest number of recognized HPA (20 of 33) resides on the GPIIb/IIIa complex, which serves as the receptor for ligands important in mediating haemostasis and inflammation. These include HPA-1a, the most commonly implicated HPA in FNAIT and PTP in Caucasian populations. Other platelet GP complexes, GPIb/V/IX, GPIa/IIa and CD109, express the remaining 13 HPAs. Of the recognized HPAs, 12 occur as six serologically and genetically defined biallelic 'systems' where the -a form designates the higher frequency allele and the -b form, the lower. Twenty-one other HPAs are low-frequency or rare antigens for which postulated higher frequency -a alleles have not yet been identified as antibody specificities. In addition to the HPA markers, platelets also express ABO and human leucocyte antigen (HLA) antigens; antibodies directed at the former are occasionally important in FNAIT, and to the latter, in MPR. © 2013 International Society of Blood Transfusion.

  7. Multiply Surface-Functionalized Nanoporous Carbon for Vehicular Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Pfeifer, Peter [Univ. of Missouri, Columbia, MO (United States). Dept. of Physics; Gillespie, Andrew [Univ. of Missouri, Columbia, MO (United States). Dept. of Physics; Stalla, David [Univ. of Missouri, Columbia, MO (United States). Dept. of Physics; Dohnke, Elmar [Univ. of Missouri, Columbia, MO (United States). Dept. of Physics

    2017-02-20

    The purpose of the project “Multiply Surface-Functionalized Nanoporous Carbon for Vehicular Hydrogen Storage” is the development of materials that store hydrogen (H2) by adsorption in quantities and at conditions that outperform current compressed-gas H2 storage systems for electric power generation from hydrogen fuel cells (HFCs). Prominent areas of interest for HFCs are light-duty vehicles (“hydrogen cars”) and replacement of batteries with HFC systems in a wide spectrum of applications, ranging from forklifts to unmanned areal vehicles to portable power sources. State-of-the-art compressed H2 tanks operate at pressures between 350 and 700 bar at ambient temperature and store 3-4 percent of H2 by weight (wt%) and less than 25 grams of H2 per liter (g/L) of tank volume. Thus, the purpose of the project is to engineer adsorbents that achieve storage capacities better than compressed H2 at pressures less than 350 bar. Adsorption holds H2 molecules as a high-density film on the surface of a solid at low pressure, by virtue of attractive surface-gas interactions. At a given pressure, the density of the adsorbed film is the higher the stronger the binding of the molecules to the surface is (high binding energies). Thus, critical for high storage capacities are high surface areas, high binding energies, and low void fractions (high void fractions, such as in interstitial space between adsorbent particles, “waste” storage volume by holding hydrogen as non-adsorbed gas). Coexistence of high surface area and low void fraction makes the ideal adsorbent a nanoporous monolith, with pores wide enough to hold high-density hydrogen films, narrow enough to minimize storage as non-adsorbed gas, and thin walls between pores to minimize the volume occupied by solid instead of hydrogen. A monolith can be machined to fit into a rectangular tank (low pressure, conformable tank), cylindrical tank

  8. DNA-Cryptography-Based Obfuscated Systolic Finite Field Multiplier for Secure Cryptosystem in Smart Grid

    Science.gov (United States)

    Chen, Shaobo; Chen, Pingxiuqi; Shao, Qiliang; Basha Shaik, Nazeem; Xie, Jiafeng

    2017-05-01

    The elliptic curve cryptography (ECC) provides much stronger security per bits compared to the traditional cryptosystem, and hence it is an ideal role in secure communication in smart grid. On the other side, secure implementation of finite field multiplication over GF(2 m ) is considered as the bottle neck of ECC. In this paper, we present a novel obfuscation strategy for secure implementation of systolic field multiplier for ECC in smart grid. First, for the first time, we propose a novel obfuscation technique to derive a novel obfuscated systolic finite field multiplier for ECC implementation. Then, we employ the DNA cryptography coding strategy to obfuscate the field multiplier further. Finally, we obtain the area-time-power complexity of the proposed field multiplier to confirm the efficiency of the proposed design. The proposed design is highly obfuscated with low overhead, suitable for secure cryptosystem in smart grid.

  9. Polarization of X rays of multiply charged ions in dense high-temperature plasma

    NARCIS (Netherlands)

    Baronova, EO; Dolgov, AN; Yakubovskii, LK

    2004-01-01

    The development of a method for studying the features of X-ray emission by multiply charged ions in a dense hot plasma is considered. These features are determined by the radiation polarization phenomenon.

  10. Tribochemistry of Multiply-Alkylated Cyclopentane Oils on DLC-Coated Thrust Bearings

    National Research Council Canada - National Science Library

    Lince, Jeffrey R; Bertrand, Patricia A

    2007-01-01

    .... We have conducted a study of H-DLC-coated steel thrust bearings, lubricated with a multiply-alkylated cyclopentane oil, either unformulated, or formulated with lead naphthenate or an aryl phosphate ester mixture...

  11. A discussion on the mechanics of lipid membranes: Lagrange multipliers and a singular substrate

    Science.gov (United States)

    Kim, Chun Il

    2017-08-01

    We present rigorous analysis of Lagrange multipliers arising in the variational computations of a membrane's energy functional. Through the convergence analysis, it is found that the local Lagrange multiplier is sensitive to the properties of membranes. Unlike the local Lagrange multiplier, the bulk liquid incompressibility condition via the global Lagrangian field acts as an additional boundary input rather than a constraint, in the perspective of the surrounding membrane. With the enhanced understanding of Lagrange multiplier fields, a membrane-substrate interaction problem is considered where singularities are present at the cross section of the substrate. A viable analytical solution is obtained under the modified boundary conditions. In addition, a complete analysis of necessary boundary condition in the case of flat surfaces is presented within the prescription of superposed incremental deformations.

  12. Atlantic Richfield Hanford Company californium multiplier/delayed neutron counter safety analysis

    International Nuclear Information System (INIS)

    Zimmer, W.H.

    1976-08-01

    The Californium Multiplier (CFX) is a subcritical assembly of uranium surrounding 252 Cf spontaneously fissioning neutron sources; its function is to multiply the neutron flux to a level useful for activation analysis. This document summarizes the safety analysis aspects of the CFX, DNC, pneumatic transfer system, and instrumentation and to detail all the aspects of the total facility as a starting point for the ARHCO Safety Analysis Review. Recognized hazards and steps already taken to neutralize them are itemized

  13. Productivity cost calculations in health economic evaluations: correcting for compensation mechanisms and multiplier effects.

    Science.gov (United States)

    Krol, Marieke; Brouwer, Werner B F; Severens, Johan L; Kaper, Janneke; Evers, Silvia M A A

    2012-12-01

    Productivity costs related to paid work are commonly calculated in economic evaluations of health technologies by multiplying the relevant number of work days lost with a wage rate estimate. It has been argued that actual productivity costs may either be lower or higher than current estimates due to compensation mechanisms and/or multiplier effects (related to team dependency and problems with finding good substitutes in cases of absenteeism). Empirical evidence on such mechanisms and their impact on productivity costs is scarce, however. This study aims to increase knowledge on how diminished productivity is compensated within firms. Moreover, it aims to explore how compensation and multiplier effects potentially affect productivity cost estimates. Absenteeism and compensation mechanisms were measured in a randomized trial among Dutch citizens examining the cost-effectiveness of reimbursement for smoking cessation treatment. Multiplier effects were extracted from published literature. Productivity costs were calculated applying the Friction Cost Approach. Regular estimates were subsequently adjusted for (i) compensation during regular working hours, (ii) job dependent multipliers and (iii) both compensation and multiplier effects. A total of 187 respondents included in the trial were useful for inclusion in this study, based on being in paid employment, having experienced absenteeism in the preceding six months and completing the questionnaire on absenteeism and compensation mechanisms. Over half of these respondents stated that their absenteeism was compensated during normal working hours by themselves or colleagues. Only counting productivity costs not compensated in regular working hours reduced the traditional estimate by 57%. Correcting for multiplier effects increased regular estimates by a quarter. Combining both impacts decreased traditional estimates by 29%. To conclude, large amounts of lost production are compensated in normal hours. Productivity costs

  14. Utilization of a channel electron multiplier for counting-measurement on condensed molecular jet

    International Nuclear Information System (INIS)

    Le Bihan, A.M.; Bottiglioni, F.; Coutant, J.; Fois, M.; CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92

    1974-01-01

    A channel electron multiplier has been used for counting ionized clusters containing up to a few thousands molecules; clusters are accelerated towards a negative (approximately-220V) copper target; a larger negative bias (approximately-3000V) is applied to the multiplier entrance so as to collect positive secondary ions and/or reflected cluster fragments; in the present application this gives better signal to noise ratio than detecting clusters directly or by secondary electron emission on the target [fr

  15. Analysis of multiplier effects of ICT sectors – a Croatian case

    OpenAIRE

    Damira Keček; Nikolina Žajdela Hrustek; Vesna Dušak

    2016-01-01

    The impact of Information and Communication Technology (ICT) on economic growth and development has nowadays proven to be significant for almost all national economies. In this paper, a quantitative analysis of the impact of ICT on Croatian economic growth is performed using the input-output (IO) method. The direct and indirect effects of ICT sectors are analysed. Subsequently, simple output multipliers and simple value added multipliers are then calculated. The results indicate that there ar...

  16. SIMAC - A phosphoproteomic strategy for the rapid separation of mono-phosphorylated from multiply phosphorylated peptides

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Robinson, Phillip J

    2008-01-01

    spectrometric analysis, such as immobilized metal affinity chromatography or titanium dioxide the coverage of the phosphoproteome of a given sample is limited. Here we report a simple and rapid strategy - SIMAC - for sequential separation of mono-phosphorylated peptides and multiply phosphorylated peptides from...... and an optimized titanium dioxide chromatographic method. More than double the total number of identified phosphorylation sites was obtained with SIMAC, primarily from a three-fold increase in recovery of multiply phosphorylated peptides....

  17. Ghost-free F(R) gravity with Lagrange multiplier constraint

    Science.gov (United States)

    Nojiri, S.; Odintsov, S. D.; Oikonomou, V. K.

    2017-12-01

    We propose two new versions of ghost-free generalized F (R) gravity with Lagrange multiplier constraint. The first version of such theory for a particular degenerate choice of the Lagrange multiplier, corresponds to mimetic F (R) gravity. The second version of such theory is just the Jordan frame description of mimetic gravity with potential. As we demonstrate, it is possible to realize several cosmological scenarios in such theory. In particular, de Sitter solutions may also be found.

  18. Beyond the static money multiplier: in search of a dynamic theory of money

    OpenAIRE

    Berardi, Michele

    2007-01-01

    In this paper, we analyze the process of money creation in a credit economy. We start from the consideration that the traditional money multiplier is a poor description of this process and present an alternative and dynamic approach that takes into account the heterogeneity of agents in the economy and their interactions. We show that this heterogeneity can account for the instability of the multiplier and that it can make the system path-dependent. By using concepts and techniques borrowed f...

  19. Toward an Algorithmic Pedagogy

    Directory of Open Access Journals (Sweden)

    Holly Willis

    2007-01-01

    Full Text Available The demand for an expanded definition of literacy to accommodate visual and aural media is not particularly new, but it gains urgency as college students transform, becoming producers of media in many of their everyday social activities. The response among those who grapple with these issues as instructors has been to advocate for new definitions of literacy and particularly, an understanding of visual literacy. These efforts are exemplary, and promote a much needed rethinking of literacy and models of pedagogy. However, in what is more akin to a manifesto than a polished argument, this essay argues that we need to push farther: What if we moved beyond visual rhetoric, as well as a game-based pedagogy and the adoption of a broad range of media tools on campus, toward a pedagogy grounded fundamentally in a media ecology? Framing this investigation in terms of a media ecology allows us to take account of the multiply determining relationships wrought not just by individual media, but by the interrelationships, dependencies and symbioses that take place within the dynamic system that is today’s high-tech university. An ecological approach allows us to examine what happens when new media practices collide with computational models, providing a glimpse of possible transformations not only ways of being but ways of teaching and learning. How, then, may pedagogical practices be transformed computationally or algorithmically and to what ends?

  20. Human reliability under sleep deprivation: Derivation of performance shaping factor multipliers from empirical data

    International Nuclear Information System (INIS)

    Griffith, Candice D.; Mahadevan, Sankaran

    2015-01-01

    This paper develops a probabilistic approach that could use empirical data to derive values of performance shaping factor (PSF) multipliers for use in quantitative human reliability analysis (HRA). The proposed approach is illustrated with data on sleep deprivation effects on performance. A review of existing HRA methods reveals that sleep deprivation is not explicitly included at present, and expert opinion is frequently used to inform HRA model multipliers. In this paper, quantitative data from empirical studies regarding the effect of continuous hours of wakefulness on performance measures (reaction time, accuracy, and number of lapses) are used to develop a method to derive PSF multiplier values for sleep deprivation, in the context of the SPAR-H model. Data is extracted from the identified studies according to the meta-analysis research synthesis method and used to investigate performance trends and error probabilities. The error probabilities in test and control conditions are compared, and the resulting probability ratios are suggested for use in informing the selection of PSF multipliers in HRA methods. Although illustrated for sleep deprivation, the proposed methodology is general, and can be applied to other performance shaping factors. - Highlights: • Method proposed to derive performance shaping factor multipliers from empirical data. • Studies reporting the effect of sleep deprivation on performance are analyzed. • Test data using psychomotor vigilance tasks are analyzed. • Error probability multipliers computed for reaction time, lapses, and accuracy measures.

  1. Substructuring by Lagrange multipliers for solids and plates

    Energy Technology Data Exchange (ETDEWEB)

    Mandel, J.; Tezaur, R. [Univ. of Colorado, Denver, CO (United States); Farhat, C. [Univ. of Colorado, Boulder, CO (United States)

    1996-12-31

    We present principles and theoreretical foundation of a substructuring method for large structural problems. The algorithm is preconditioned conjugate gradients on a subspace for the dual problem. The preconditioning is proved asymptotically optimal and the method is shown to be parallel scalable, i.e., the condition number is bounded independently of the number of substructures. For plate problems, a special modification is needed that retains continuity of the displacement solution at substructure crosspoints, resulting in an asymptically optimal method. The results are confirmed by numerical experiments.

  2. Exact and efficient calculation of Lagrange multipliers in biological polymers with constrained bond lengths and bond angles: proteins and nucleic acids as example cases.

    Science.gov (United States)

    García-Risueño, Pablo; Echenique, Pablo; Alonso, J L

    2011-11-15

    To accelerate molecular dynamics simulations, it is common to impose holonomic constraints on the hardest degrees of freedom. In this way, the time step used to integrate the equations of motion can be increased, thereby allowing longer total simulation times. The imposition of such constraints results in an aditional set of N(c) equations (the equations of constraint) and unknowns (their associated Lagrange multipliers), whose solution is closely related to any algorithm implementing the constraints in Euclidean coordinates. In this work, it is shown that, due to the essentially linear structure of typical biological polymers the algebraic equations that need to be solved involve a matrix which is not only sparse, but also banded if the constraints are indexed in a skilful way. This allows the Lagrange multipliers to be obtained through a noniterative procedure, which can be considered exact up to machine precision, and which takes O(N(c)) operations, instead of the usual O(N c3) for generic molecular systems. We develop the formalism, and describe the appropriate indexing for a number of model molecules. Finally, we provide a numerical example of the technique in a series of polyalanine peptides of different lengths. Although a use of the Lagrange multipliers without any modification in the solution of the underlying ordinary differential equations yields unstable integration algorithms, the central role of these quantities makes their efficient calculation useful for the improvement of methods that correctly enforce the exact satisfaction of the constraints at each time step. We provide several examples of this. Copyright © 2011 Wiley Periodicals, Inc.

  3. СAPSULAR ANTIGEN OF YERSINIA PESTIS

    Directory of Open Access Journals (Sweden)

    L. A. Kadnikova

    2015-01-01

    Full Text Available Plague is a zoonosis caused by gram-negative bacteria Yersinia pestis, which, as a rule, is transmitted to humans from septicemic rodents by the bites of infected fleas. This microbe killed more people than all of the wars in the human history. Y. pestis circulation in the natural plague foci is ensured by the whole number of pathogenicity factors with differing functional orientation. This review is devoted to one of them, Y. pestis capsular antigen (F1 or Caf1. The history of its discovery and studying of its genetic control, biosynthesis, isolation and purification, and physicochemical properties are reviewed. Its roles in plague pathogenesis and its application as a main component of plague vaccines are also discussed. Y. pestis capsule under light microscopy is visually amorphous, while high-resolution electron microscopy displays the structure formed from separate fimbria-like cords up to 200 nm long, diverging from the bacterial surface in different directions. At 37°C Y. pestis produce 800–1000 times more capsular antigen than at 28°C. Genes coding for 17.6-kD Caf1 protein, which contains 170 amino acids, are located in caf1 operon of pFra plasmid. Analysis of caf1 operon nucleotide sequence testified its close phylogenetic relationship with the gene clusters coding for pilus adhesins that were secreted with the help of chaperone/usher systems in enterobacteria including six additional adhesins in Y. pestis. Y. pestis multiplication within macrophages is the obligatory stage of plague pathogenesis, and the plague pathogen virulence correlates not with resistance to phagocyte ingesting but with bacterial ability to survive and multiply within phagolysosomes of phagocytes due to neutralization of antibacterial functions of eukaryotic cells. The capsule formed out of the Caf1 aggregates protects Y. pestis from ingestion by naïve host’s phagocytes and prevents from initiation of the alternative pathway of the complement system

  4. Cancer testis antigen and immunotherapy

    Directory of Open Access Journals (Sweden)

    Krishnadas DK

    2013-04-01

    Full Text Available Deepa Kolaseri Krishnadas, Fanqi Bai, Kenneth G Lucas Department of Pediatrics, Division of Hematology/Oncology, University of Louisville, KY, USA Abstract: The identification of cancer testis (CT antigens has been an important advance in determining potential targets for cancer immunotherapy. Multiple previous studies have shown that CT antigen vaccines, using both peptides and dendritic cell vaccines, can elicit clinical and immunologic responses in several different tumors. This review details the expression of melanoma antigen family A, 1 (MAGE-A1, melanoma antigen family A, 3 (MAGE-A3, and New York esophageal squamous cell carcinoma-1 (NY-ESO-1 in various malignancies, and presents our current understanding of CT antigen based immunotherapy. Keywords: cancer testis antigens, immunotherapy, vaccine

  5. Determination of stress multipliers for thin perforated plates with square array of holes

    International Nuclear Information System (INIS)

    Bhattacharya, A.; Murli, B.; Kushwaha, H.S.

    1991-01-01

    The peak stress multipliers are required to determine the maximum stresses in perforated plates for the realistic evaluation of their fatigue life. The Section III of ASME Boiler and Pressure Vessels Code does not provide any information about such multipliers to be used in thin perforated plates with square penetration pattern. Although such multipliers for membrane loadings are available in literature, they were obtained either by classical analysis or by photoelastic experiments and there is no significant finite element analysis in this area. Also it has been a common practice among designers to apply the same multipliers for loads producing bending type of stress. The stress multipliers in bending are lower than those in membrane. Therefore a reduction of resultant peak stress occurs if proper stress multipliers are used for bending. The present paper is aimed at developing a finite element technique which can be used for determining the peak stress multipliers in thin plates for membrane as well as bending loads. A quarter symmetric part of a 3 x 3 square array was chosen for the analysis. The results were obtained by computer programs PAFEC and COSMOS/M using 2-D plane stress elements for the membrane and degenerated 3-D shell element for the bending part. The results for the membrane are compared with Bailey, Hicks and Hulbert and with Meijers' finite element results for the bending part. A study was made at the initial stage by analysing a 6 x 6 square array to see the effect of holes beyond one pitch, which were left out by the 3 x 3 array and the effect of additional holes was found to be negligible. Therefore it was decided to carry out further analysis with 3 x 3 square array. Photoelastic experiments were also performed to validate the results obtained by theoretical analysis. (author)

  6. Antigen antibody interactions

    CERN Document Server

    DeLisi, Charles

    1976-01-01

    1. 1 Organization of the Immune System One of the most important survival mechanisms of vertebrates is their ability to recognize and respond to the onslaught of pathogenic microbes to which they are conti- ously exposed. The collection of host cells and molecules involved in this recognition­ 12 response function constitutes its immune system. In man, it comprises about 10 cells 20 (lymphocytes) and 10 molecules (immunoglobulins). Its ontogenic development is c- strained by the requirement that it be capable of responding to an almost limitless variety of molecular configurations on foreign substances, while simultaneously remaining inert to those on self components. It has thus evolved to discriminate, with exquisite precision, between molecular patterns. The foreign substances which induce a response, called antigens, are typically large molecules such as proteins and polysaccharides. The portions of these with which immunoglobulins interact are called epitopes or determinants. A typical protein epitope m...

  7. Cancer antigen 125 and prognosis

    DEFF Research Database (Denmark)

    Høgdall, Estrid Vilma Solyom

    2008-01-01

    cancer antigen 125 determination may be implemented into clinical practice, cut-off levels must be evaluated and internationally defined. Studies examining serum cancer antigen 125 levels after surgery but before, during, or after treatment confirmed that changes in serum levels are of prognostic value...

  8. Design of Low Power Multiplier with Energy Efficient Full Adder Using DPTAAL

    Directory of Open Access Journals (Sweden)

    A. Kishore Kumar

    2013-01-01

    Full Text Available Asynchronous adiabatic logic (AAL is a novel lowpower design technique which combines the energy saving benefits of asynchronous systems with adiabatic benefits. In this paper, energy efficient full adder using double pass transistor with asynchronous adiabatic logic (DPTAAL is used to design a low power multiplier. Asynchronous adiabatic circuits are very low power circuits to preserve energy for reuse, which reduces the amount of energy drawn directly from the power supply. In this work, an 8×8 multiplier using DPTAAL is designed and simulated, which exhibits low power and reliable logical operations. To improve the circuit performance at reduced voltage level, double pass transistor logic (DPL is introduced. The power results of the proposed multiplier design are compared with the conventional CMOS implementation. Simulation results show significant improvement in power for clock rates ranging from 100 MHz to 300 MHz.

  9. Proposal for electro-optic multiplier based on dual transverse electro-optic Kerr effect.

    Science.gov (United States)

    Li, Changsheng

    2008-10-20

    A novel electro-optic multiplier is proposed, which can perform voltage multiplication operation by use of the Kerr medium exhibiting dual transverse electro-optic Kerr effect. In this kind of Kerr medium, electro-optic phase retardation is proportional to the square of its applied electric field, and orientations of the field-induced birefringent axes are only related to the direction of the field. Based on this effect, we can design an electro-optic multiplier by selecting the crystals of 6/mmm, 432, and m3m classes and isotropic Kerr media such as glass. Simple calculation demonstrates that a kind of glass-ceramic material with a large Kerr constant can be used for the design of the proposed electro-optic multiplier.

  10. Economic Multipliers and Sectoral Linkages: Ghana and the New Oil Sector

    Directory of Open Access Journals (Sweden)

    Dennis Nchor

    2016-01-01

    Full Text Available The study seeks to assess the structure of the economy of Ghana in terms of changes in the economic structure before and after the production of oil in commercial quantities. This is viewed with regards to economic multipliers, sectoral interdependence and trade concentration. The results show that changes occurred with regards to multipliers and sectoral interdependence. The output multipliers of most sectors have declined. The results also show that the agricultural sector experienced an initial decline in its growth while industry experienced an increase. The performance of the services sector was relatively stable for the period covered by the study. There is a decline in the level of trade concentration though on a whole the concentration index is still high. The study employed input-output modeling techniques and the data was obtained from the Ghana statistical service and the World Development Indicators.

  11. Combinatorial algorithms

    CERN Document Server

    Hu, T C

    2002-01-01

    Newly enlarged, updated second edition of a valuable text presents algorithms for shortest paths, maximum flows, dynamic programming and backtracking. Also discusses binary trees, heuristic and near optimums, matrix multiplication, and NP-complete problems. 153 black-and-white illus. 23 tables.Newly enlarged, updated second edition of a valuable, widely used text presents algorithms for shortest paths, maximum flows, dynamic programming and backtracking. Also discussed are binary trees, heuristic and near optimums, matrix multiplication, and NP-complete problems. New to this edition: Chapter 9

  12. Radioimmunoassays of hidden viral antigens

    International Nuclear Information System (INIS)

    Neurath, A.R.; Strick, N.; Baker, L.; Krugman, S.

    1982-01-01

    Antigens corresponding to infectious agents may be present in biological specimens only in a cryptic form bound to antibodies and, thus, may elude detection. We describe a solid-phase technique for separation of antigens from antibodies. Immune complexes are precipitated from serum by polyethylene glycol, dissociated with NaSCN, and adsorbed onto nitrocellulose or polystyrene supports. Antigens remain topographically separated from antibodies after removal of NaSCN and can be detected with radiolabeled antibodies. Genomes from viruses immobilized on nitrocellulose can be identified by nucleic acid hybridization. Nanogram quantities of sequestered hepatitis B surface and core antigens and picogram amounts of hepatitis B virus DNA were detected. Antibody-bound adenovirus, herpesvirus, and measles virus antigens were discerned by the procedure

  13. Estimation of multiply digital process control system extractive distillation stability

    Directory of Open Access Journals (Sweden)

    V. S. Kudryashov

    2016-01-01

    Full Text Available An approach to stability analysis of digital control systems associated non-stationary object on the example of the rectification process. Object modeling with cross-connections and the control scheme of the described system, discrete transfer functions in the shift operators. The equations of connection for each output of the closed-loop system. To solve this problem developed an algorithm for estimating the margin of stability of multivariable digital control systems based on the discrete root criterion, comprising the following main stages: obtaining of the characteristic polynomial of the closed-loop system for each output; computation of eigenvalues of the system matrix in the state space to determine roots of the characteristic equation and the stability of the system; determination of the stability and margin of stability by the deviation of maximum module of the root from the boundary of the high variability. To obtain the characteristic polynomial of a as discrete models of controllers and channels of IP object-use the transfer function of the first order with transport delay. The simulation was performed at different parameters of the control object, which is characterized by a stable and an unstable state of the system. VA-den analysis of the numerical values of the roots and character of their location on the complex plane, which to you-water that the system is stable or unstable. To confirm the obtained results were calculated and presented dynamic characteristics of the closed-loop system under different conditions, which confirm the initial assessment, the root criterion. To determine the factor stability of multivariable digital systems is proposed to use the deviation of the maximum root of the characteristic equation from the stability boundary. The obtained results apply to the class of symmetric multivariable control objects. The approach to assessing the sustainability of multivariable system regulation can be effectively

  14. Electronic de-multipliers II (ring-shape systems); Demultiplieurs electroniques II (systeme en anneau)

    Energy Technology Data Exchange (ETDEWEB)

    Raievski, V

    1948-09-01

    This report describes a new type of ring-shape fast electronic counter (de-multiplier) with a resolution capacity equivalent to the one made by Regener (Rev. of Scientific Instruments USA 1946, 17, 180-89) but requiring two-times less electronic valves. This report follows the general description of electronic de-multipliers made by J. Ailloud (CEA--001). The ring comprises 5 flip-flop circuits with two valves each. The different elements of the ring are calculated with enough details to allow the transfer of this calculation to different valve types. (J.S.)

  15. Conformal mapping of unbounded multiply connected regions onto logarithmic spiral slit with infinite straight slit

    Science.gov (United States)

    Yunus, Arif A. M.; Murid, Ali H. M.

    2017-04-01

    This paper presents a boundary integral equation method with the adjoint generalized Neumann kernel for conformal mapping of unbounded multiply connected regions. The canonical region is the entire complex plane bounded by an infinite straight slit on the line Im ω = 0 and finite logarithmic spiral slits. Some linear boundary integral equations are constructed from a boundary relationship satisfied by an analytic function on a multiply connected region. These integral equations are uniquely solvable. The kernel involved in these integral equations is the adjoint generalized Neumann kernel.

  16. Technique to eliminate computational instability in multibody simulations employing the Lagrange multiplier

    Science.gov (United States)

    Watts, G.

    1992-01-01

    A programming technique to eliminate computational instability in multibody simulations that use the Lagrange multiplier is presented. The computational instability occurs when the attached bodies drift apart and violate the constraints. The programming technique uses the constraint equation, instead of integration, to determine the coordinates that are not independent. Although the equations of motion are unchanged, a complete derivation of the incorporation of the Lagrange multiplier into the equation of motion for two bodies is presented. A listing of a digital computer program which uses the programming technique to eliminate computational instability is also presented. The computer program simulates a solid rocket booster and parachute connected by a frictionless swivel.

  17. Lagrange multipliers in elastic-plastic torsion problem for nonlinear monotone operators

    Science.gov (United States)

    Giuffrè, S.; Maugeri, A.; Puglisi, D.

    2015-08-01

    The existence of Lagrange multipliers as a Radon measure is ensured for an elastic-plastic torsion problem associated to a nonlinear strictly monotone operator. A regularization of this result, namely the existence of Lp Lagrange multipliers, is obtained under strong monotonicity assumption on the operator. Moreover, the relationships between elastic-plastic torsion problem and the obstacle problem are investigated. Finally, an example of the so-called "Von Mises functions" is provided, namely of solutions of the elastic-plastic torsion problem, associated to nonlinear monotone operators, which are not obtained by means of the obstacle problem in the case f =constant.

  18. A calculation of a half-integral weight multiplier system on SU(2,1)

    OpenAIRE

    Jalal, Lina

    2011-01-01

    In this thesis, we construct a half-integral weight multiplier system on the group SU(2,1). In order to do so, we first find a formula for a 2-cocycle representing the double cover of SU(2,1)(k), where k is a local field. For each non-archimedean local field k, we describe how the cocycle splits on a compact open subgroup. The multiplier system is then expressed in terms of the product of the local splittings at each prime.

  19. Algorithmic Self

    DEFF Research Database (Denmark)

    Markham, Annette

    layered set of accounts to help build our understanding of how individuals relate to their devices, search systems, and social network sites. This work extends critical analyses of the power of algorithms in implicating the social self by offering narrative accounts from multiple perspectives. It also...

  20. Autodriver algorithm

    Directory of Open Access Journals (Sweden)

    Anna Bourmistrova

    2011-02-01

    Full Text Available The autodriver algorithm is an intelligent method to eliminate the need of steering by a driver on a well-defined road. The proposed method performs best on a four-wheel steering (4WS vehicle, though it is also applicable to two-wheel-steering (TWS vehicles. The algorithm is based on coinciding the actual vehicle center of rotation and road center of curvature, by adjusting the kinematic center of rotation. The road center of curvature is assumed prior information for a given road, while the dynamic center of rotation is the output of dynamic equations of motion of the vehicle using steering angle and velocity measurements as inputs. We use kinematic condition of steering to set the steering angles in such a way that the kinematic center of rotation of the vehicle sits at a desired point. At low speeds the ideal and actual paths of the vehicle are very close. With increase of forward speed the road and tire characteristics, along with the motion dynamics of the vehicle cause the vehicle to turn about time-varying points. By adjusting the steering angles, our algorithm controls the dynamic turning center of the vehicle so that it coincides with the road curvature center, hence keeping the vehicle on a given road autonomously. The position and orientation errors are used as feedback signals in a closed loop control to adjust the steering angles. The application of the presented autodriver algorithm demonstrates reliable performance under different driving conditions.

  1. Genetic algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Grefenstette, J.J.

    1994-12-31

    Genetic algorithms solve problems by using principles inspired by natural population genetics: They maintain a population of knowledge structures that represent candidate solutions, and then let that population evolve over time through competition and controlled variation. GAs are being applied to a wide range of optimization and learning problems in many domains.

  2. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    Directory of Open Access Journals (Sweden)

    Xiaoxi Yan

    2014-01-01

    Full Text Available As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W function. Mixture components, whose weights become negative during iterative procedure, are pruned by setting corresponding mixture weights to zeros. In addition, multiple mixture components with similar parameters describing the same PHD peak can be merged into one mixture component in the algorithm. Simulation results show that the proposed iterative mixture component pruning algorithm is superior to the typical pruning algorithm based on thresholds.

  3. COLONOSCOPY AND CARCINOEMBRYONIC ANTIGEN VARIATIONS

    Directory of Open Access Journals (Sweden)

    Rita G SOUSA

    2014-03-01

    Full Text Available Context Colonoscopy is essential for synchronous and metachronous cancer detection. Carcinoembryonic antigen is a colorectal cancer tumor marker, important as a follow-up tool in patients with previous colorectal cancer. False-positive carcinoembryonic antigen elevation results in multiples exams and in patient anxiety. In literature, there is reference to transient carcinoembryonic antigen increase with colonoscopy. Objective To evaluate the influence of bowel preparation and colonoscopy in carcinoembryonic antigen blood levels. Methods We prospectively studied subjects that underwent routine colonoscopy in our institution. Blood samples were collected (1 before bowel cleaning, (2 before colonoscopy and (3 immediately after colonoscopy. Blood carcinoembryonic antigen levels were determined by “Sandwich” immunoassay. The statistical methods used were the paired t-test and ANOVA. Results Thirty-seven patients (22M/15F were included; age range 28-84 (mean 56 years. Mean carcinoembryonic antigen values were 1.9, 2 and 1.8 for (1, (2 and (3, respectively. An increase in value (2 compared with (1 was observed in 20/37 patients (P = 0.018, mainly in younger patients and in patients requiring more endoluminal interventions. In 29/37 patients, the CEA value decreased from (2 to (3 (P = 1.3x10-7. Conclusions A trend for carcinoembryonic antigen increase after bowel cleaning was observed, especially in younger patients and in patients with more endoluminal interventions, but without clinical meaning.

  4. Colonoscopy and carcinoembryonic antigen variations.

    Science.gov (United States)

    Sousa, Rita G; Nunes, Ana; Meira, Tânia; Carreira, Olga; Pires, Ana M; Freitas, João

    2014-01-01

    Colonoscopy is essential for synchronous and metachronous cancer detection. Carcinoembryonic antigen is a colorectal cancer tumor marker, important as a follow-up tool in patients with previous colorectal cancer. False-positive carcinoembryonic antigen elevation results in multiples exams and in patient anxiety. In literature, there is reference to transient carcinoembryonic antigen increase with colonoscopy. To evaluate the influence of bowel preparation and colonoscopy in carcinoembryonic antigen blood levels. We prospectively studied subjects that underwent routine colonoscopy in our institution. Blood samples were collected (1) before bowel cleaning, (2) before colonoscopy and (3) immediately after colonoscopy. Blood carcinoembryonic antigen levels were determined by "Sandwich" immunoassay. The statistical methods used were the paired t-test and ANOVA. Thirty-seven patients (22M/15F) were included; age range 28-84 (mean 56 years). Mean carcinoembryonic antigen values were 1.9, 2 and 1.8 for (1), (2) and (3), respectively. An increase in value (2) compared with (1) was observed in 20/37 patients (P = 0.018), mainly in younger patients and in patients requiring more endoluminal interventions. In 29/37 patients, the CEA value decreased from (2) to (3) (P = 1.3x10-7). A trend for carcinoembryonic antigen increase after bowel cleaning was observed, especially in younger patients and in patients with more endoluminal interventions, but without clinical meaning.

  5. Comparative characteristic of the methods of protein antigens epitope mapping

    Directory of Open Access Journals (Sweden)

    O. Yu. Galkin

    2014-08-01

    Full Text Available Comparative analysis of experimental methods of epitope mapping of protein antigens has been carried out. The vast majority of known techniques are involved in immunochemical study of the interaction of protein molecules or peptides with antibodies of corresponding specifici­ty. The most effective and widely applicable metho­dological techniques are those that use synthetic and genetically engineered peptides. Over the past 30 years, these groups of methods have travelled a notable evolutionary path up to the maximum automation and the detection of antigenic determinants of various types (linear and conformational epitopes, and mimotopes. Most of epitope searching algorithms were integrated into a computer program, which greatly facilitates the analysis of experimental data and makes it possible to create spatial models. It is possible to use comparative epitope mapping for solving the applied problems; this less time-consuming method is based on the analysis of competition between different antibodies interactions with the same antigen. The physical method of antigenic structure study is X-ray analysis of antigen-antibody complexes, which may be applied only to crystallizing­ proteins, and nuclear magnetic resonance.

  6. [Severe clinical problems lasting several weeks on a multiplier pig farm: what if it had been classical swine fever?].

    Science.gov (United States)

    Backer, Jantien; Spierenburg, Marcel; van der Spek, Arco; Elbers, Armin

    2010-10-15

    In the Spring of 2009, a veterinarian reported suspected classical swine fever (CSF) on a multiplier pig farm in the southern part of The Netherlands (close to the Belgian border). Over a 5-week period there had been a number of sick sows and an excessively high percentage of stillborn and preterm piglets. Sick animals were treated with anti-inflammatory drugs and antibiotics, but did not respond as well as anticipated. A visiting specialist team from the Food Safety Authority could not exclude CSF as the cause of the clinical problems and sent blood samples to the reference laboratory in Lelystad for a PCR test on CSF antigen. Fortunately, test results obtained 6 hours later were negative for CSF, and the disease control measures were lifted. It later appeared that porcine reproductive and respiratory syndrome (PRRSV) might have been responsible for the problems. But what if CSF had caused the clinical problems? A CSF-transmission model was used to simulate CSF outbreaks dependent on the duration of the high-risk period (HRP). As the duration of the HRP increased, there was an exponential growth in the number of pig farms infected during this period. Simulations also showed that with a longer HRP, the virus spread over greater distances from the source herd. It was also investigated whether a possible CSF outbreak could be detected on the basis of an increased mortality and hence increased number of cadavers sent to a rendering plant. However, the calculated mortality incidence was not sensitive enough to serve as an alarm signal. It is recommended that CSF-exclusion diagnostics be used much earlier in similar clinical situations on pig farms.

  7. Strength of the reversible, garbage-free 2 k ±1 multiplier

    DEFF Research Database (Denmark)

    Rotenberg, Eva; Cranch, James; Thomsen, Michael Kirkedal

    2013-01-01

    Recently, a reversible garbage-free 2 k ±1 constant-multiplier circuit was presented by Axelsen and Thomsen. This was the first construction of a garbage-free, reversible circuit for multiplication with non-trivial constants. At the time, the strength, that is, the range of constants obtainable...

  8. Time-area efficient multiplier-free recursive filter architectures for FPGA implementation

    DEFF Research Database (Denmark)

    Shajaan, Mohammad; Sørensen, John Aasted

    1996-01-01

    Simultaneous design of multiplier-free recursive filters (IIR filters) and their hardware implementation in Xilinx field programmable gate array (XC4000) is presented. The hardware design methodology leads to high performance recursive filters with sampling frequencies in the interval 15-21 MHz (...

  9. Bandpass x-ray diodes and x-ray multiplier tubes

    International Nuclear Information System (INIS)

    Wang, C.L.

    1982-01-01

    We present a simple method of obtaining bandpass x-ray detectors. The lower and upper bounds of the bandpass are determined by the absorption edges of the photocathode and of the filter, respectively. Examples are given for windowless and vacuum bandpass x-ray diodes. Extension of the method to electron multiplier tubes is also presented

  10. Structure of High-Speed Modulo Multiplier Suitable for Repeated Operations

    Science.gov (United States)

    Kudou, Tadamichi; Tsunekawa, Yoshitaka; Suzuki, Masayuki

    In this paper, we propose a new modulo multiplier suitable for repeated operations using redundant representations. First, we consider a computation rule for radix-2 modulo multiplications. In radix-2 operation, we show two methods to calculate (2i-1 mod n) from (2i mod n) and decide product digits sequentially from upper side. These methods make it possible to perform (2i-1 mod n) and multiplications simultaneously. Second, we attempt to apply these methods to radix-4 operations which enables us to reduce clock cycles by only shift and sign change. We propose some structures to perform each part efficiently for radix-4 modulo multiplications. The high-speed redundant binary adder/subtractor which we have already proposed is applied to these structures. By using this adder/subtractor, the longest delay path of this modulo multiplier becomes very short. Finally, by using PARTHENON which is a design system for VLSI, this modulo multiplier is designed and evaluated. As a result, we show the speed of this proposed modulo multiplier becomes over 2.5 times as compared with the conventional structures.

  11. A Low-jitter 2.5-to-10 GHz Clock Multiplier Unit in CMOS

    NARCIS (Netherlands)

    van de Beek, R.C.H.; Vaucher, C.S.; Leenaerts, D.M.W.; Klumperink, Eric A.M.; Nauta, Bram

    2003-01-01

    Abstract— This paper demonstrates a low-jitter clock multiplier unit [1] that generates a 10 GHz output clock from a 2.5 GHz reference clock. An integrated 10 GHz LCoscillator is locked to the input clock, using a simple and fast phase detector circuit. This phase detector overcomes the speed

  12. Pointwise Multipliers on Spaces of Homogeneous Type in the Sense of Coifman and Weiss

    Directory of Open Access Journals (Sweden)

    Yanchang Han

    2014-01-01

    homogeneous type in the sense of Coifman and Weiss, pointwise multipliers of inhomogeneous Besov and Triebel-Lizorkin spaces are obtained. We make no additional assumptions on the quasi-metric or the doubling measure. Hence, the results of this paper extend earlier related results to a more general setting.

  13. Limitations in THz Power Generation with Schottky Diode Varactor Frequency Multipliers

    DEFF Research Database (Denmark)

    Krozer, Viktor; Loata, G.; Grajal, J.

    2002-01-01

    We discuss the limitations in power generation with Schottky diode and HBV (heterostructure barrier varactor) diode frequency multipliers. It is shown that at lower frequencies the experimental results achieved so far approach the theoretical limit of operation for the employed devices. However...

  14. Carbon composite based on Multiaxial Multiply Stiched Preforms. Part V: Geometry of Sheared Biaxial Fabrics

    NARCIS (Netherlands)

    Loendersloot, Richard; Lomov, S.V.; Akkerman, Remko; Verpoest, I.

    2006-01-01

    The geometry of multiaxial multiply carbon reinforcement under shear deformation is studied. A description based on the distortions of the fibres bundles, induced by the stitch yarn is proposed. These distortions are recognised to be dominant for the impregnation behaviour and the damage initiation,

  15. Implementation of neutron activation analysis in the neutron multiplier CS-ISCTN (first part)

    International Nuclear Information System (INIS)

    Contreras, R.; Ixquiac, M.; Hernandez, O.; Herrera, E.F.; Diaz, O.; Lopez, R.; Alvarez, I.; Manso, M.V.; Padron, G.; D Alessandro, K.

    1997-01-01

    The detection limit of 32 elements are determined after experimental evaluation of the neutron flux components in the irradiation position of the neutron multiplier CS-ISCTN. The control of the thermal flux was carry up, comparing the experimental results obtained through three convention used determination of the reaction rate, with the theoretical obtained before

  16. Use of a tubular multiplier in counting measurements with a condensed molecular jet

    Energy Technology Data Exchange (ETDEWEB)

    Le Bihan, A.M.; Bottiglioni, F.; Coutant, J.; Fois, M.

    1973-12-31

    From fourth international symposium on molecular jets; Cannes, France (9 Jul 1973). A tubular multiplier was used for counting measurements in studies of the cross sections for granion production encountered in reactions occurring in molecular jets produced by electron bombardment. (auth)

  17. Implementation gap between the theory and practice of biodiversity offset multipliers

    DEFF Research Database (Denmark)

    Bull, Joseph William; Lloyd, Samuel P.; Strange, Niels

    2017-01-01

    Emerging policies worldwide require biodiversity gains as compensation for losses associated with economic development, seeking to achieve “no net loss” (NNL). Multipliers – factors by which gains are larger than associated losses – can be crucial for true NNL. Here, we review the theoretical...

  18. The correspondence between stochastic mechanics and quantum mechanics on multiply connected configuration spaces

    International Nuclear Information System (INIS)

    Carlen, E.A.; Loffredo, M.I.

    1989-01-01

    We show how to obtain a complete correspondence between stochastic and quantum mechanics on multiply connected spaces. We do this by introducing a stochastic mechanical analog of the hydrodynamical circulation, relating it to the topological properties of the configuration space, and using it to constrain the stochastic mechanical variational principles. (orig.)

  19. Isometric multipliers of Lp (G, X) Lp (G, X) Lp (G, X)

    Indian Academy of Sciences (India)

    Let be a locally compact group with a fixed right Haar measure and a separable Banach space. Let L p ( G , X ) be the space of -valued measurable functions whose norm-functions are in the usual L p . A left multiplier of L p ( G , X ) is a bounded linear operator on L p ( G , X ) which commutes with all left translations.

  20. A low-phase noise frequency multiplier chain | Abdo | Zede Journal

    African Journals Online (AJOL)

    'In this paper a low phase-noise frequency multiplier chain from lOMHz to 480MHz, built in two stages and intended for use as a base for the synthesis of frequencies upto the far infrared (FIR) region, is presented. Different methods of frequency multiplication were used and the associated circuit diagrams given.

  1. Energy and intensity distributions of 279 keV multiply scattered ...

    Indian Academy of Sciences (India)

    Abstract. An inverse response matrix converts the observed pulse-height distribution of a NaI(Tl) scintillation detector to a true photon spectrum. This also results in extrac- tion of intensity and energy distributions of multiply scattered events originating from interactions of 279 keV photons with thick targets of bronze.

  2. A SUITABLE CONTROL SCHEME FOR THE BINARY MULTIPLIER DATA BANK OF VLSI CAD

    Directory of Open Access Journals (Sweden)

    O. I. Tymoshkin

    2009-09-01

    Full Text Available Problem of elaborating a databank of testable digital elements, units and modules, which are most typical for digital systems, is considered. For this bank an original testable logical circuit of matrix binary multiplier, demanding small amount of hardware for its realization, is proposed.

  3. Improved 64-bit Radix-16 Booth Multiplier Based on Partial Product Array Height Reduction

    DEFF Research Database (Denmark)

    Antelo, Elisardo; Montuschi, Paolo; Nannarelli, Alberto

    2016-01-01

    , a reduction of one unit in the maximum height is achieved. This reduction may add flexibility during the design of the pipelined multiplier to meet the design goals, it may allow further optimizations of the partial product array reduction stage in terms of area/delay/power and/or may allow additional addends...

  4. A Classical Conditioning Procedure for the Hearing Assessment of Multiply Handicapped Persons.

    Science.gov (United States)

    Lancioni, Giulio E.; And Others

    1989-01-01

    Hearing assessments of multiply handicapped children/adolescents were conducted using classical conditioning (with an air puff as unconditioned stimulus) and operant conditioning (with a modified visual reinforcement audiometry procedure or edible reinforcement). Findings indicate that classical conditioning was successful with 21 of the 23…

  5. Radiation-hardened I2L 8*8 multiplier circuit

    International Nuclear Information System (INIS)

    Doyle, B.R.; Kreps, S.A.; Van Vonno, N.W.; Lake, G.W.

    1979-01-01

    Development of improved Substrate Fed I 2 L (SFL) processing has been combined with geometry and fanout constraints to design a radiation hardened LSI 8.8 Multiplier. This study describes details of the process and circuit design and gives resultant electrical and radiation test performance

  6. Full inelastic cross section, effective stopping and ranges of fast multiply charged ions

    International Nuclear Information System (INIS)

    Alimov, R.A.; Arslanbekov, T.U.; Matveev, B.I.; Rakhmatov, A.S.

    1994-01-01

    Inelastic processes taking place in collision of fast multiply charged ions with atoms are considered on the base of mechanism of sudden momentum transfer. The simple estimations are proposed of full inelastic cross sections, effective stopping and ion ranges in gaseous medium. (author). 10 refs

  7. The impact of founder events on chromosomal variability in multiply mating species

    DEFF Research Database (Denmark)

    Pool, John E; Nielsen, Rasmus

    2008-01-01

    size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect-that of founder events involving multiply mated females-and find that it leads to much stronger reductions in X/A diversity ratios than...

  8. The Multiplier Effect: A Strategy for the Continuing Education of School Psychologists

    Science.gov (United States)

    Lesiak, Walter; And Others

    1975-01-01

    Twenty-two school psychologists participated in a year long institute designed to test the use of a multiplier effect in the continuing professional development of school psychologists in Michigan. Results indicated that 550 school psychologists attended two in-service meetings with generally favorable reactions. (Author)

  9. The net multiplier is a new key sector indicator : Reply to De Mesnard's comment

    NARCIS (Netherlands)

    Oosterhaven, Jan

    Most of the comment of de Mesnard applies to a causal interpretation of the net multiplier that is applied to economically impossible exogenous (changes in) total output. This reply shows that this interpretation is incorrect and that his further argumentation is based on a time inconsistent

  10. Detection of Differential Item Functioning Using Lagrange Multiplier Tests. Research Report 96-02.

    Science.gov (United States)

    Glas, Cees A. W.

    In this paper it is shown that differential item functioning can be evaluated using the Lagrange multiplier test or C. R. Rao's efficient score test. The test is presented in the framework of a number of item response theory (IRT) models such as the Rasch model, the one-parameter logistic model, the two-parameter logistic model, the generalized…

  11. A Lagrange Multiplier Test for Testing the Adequacy of the Constant Conditional Correlation GARCH Model

    DEFF Research Database (Denmark)

    Catani, Paul; Teräsvirta, Timo; Yin, Meiqun

    A Lagrange multiplier test for testing the parametric structure of a constant conditional correlation generalized autoregressive conditional heteroskedasticity (CCC-GARCH) model is proposed. The test is based on decomposing the CCC-GARCH model multiplicatively into two components, one of which...

  12. The Development of a Program in Orientation and Mobility for Multiply Impaired Blind Children. Final Report.

    Science.gov (United States)

    Harley, Randall K.; And Others

    In the final report on the project to develop programed instruction in orientation and mobility for use by teachers of multiply impaired blind children, the development of the evaluation scales and programed instruction in four basic areas of precane training, the results of field testing, and the dissemination activities are described. An…

  13. Model Modification in Covariance Structure Modeling: A Comparison among Likelihood Ratio, Lagrange Multiplier, and Wald Tests.

    Science.gov (United States)

    Chou, Chih-Ping; Bentler, P. M.

    1990-01-01

    The empirical performance under null/alternative hypotheses of the likelihood ratio difference test (LRDT); Lagrange Multiplier test (evaluating the impact of model modification with a specific model); and Wald test (using a general model) were compared. The new tests for covariance structure analysis performed as well as did the LRDT. (RLC)

  14. Modeling of Schottky Barrier Diode Millimeter-Wave Multipliers at Cryogenic Temperatures

    DEFF Research Database (Denmark)

    Johansen, Tom K.; Rybalko, Oleksandr; Zhurbenko, Vitaliy

    2015-01-01

    We report on the evaluation of Schottky barrier diode GaAs multipliers at cryogenic temperatures. A GaAs Schottky barrier diode model is developed for theoretical estimation of doubler performance. The model is used to predict efficiency of doublers from room to cryogenic temperatures. The theore...

  15. Dynamics of chemical reactions of multiply-charged cations: Information from beam scattering experiments

    Czech Academy of Sciences Publication Activity Database

    Herman, Zdeněk

    2015-01-01

    Roč. 378, FEB 2015 (2015), s. 113-126 ISSN 1387-3806 Institutional support: RVO:61388955 Keywords : Multiply-charged ions * Dynamics of chemical reactions * Beam scattering Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.183, year: 2015

  16. Mixed Analog/Digital Matrix-Vector Multiplier for Neural Network Synapses

    DEFF Research Database (Denmark)

    Lehmann, Torsten; Bruun, Erik; Dietrich, Casper

    1996-01-01

    In this work we present a hardware efficient matrix-vector multiplier architecture for artificial neural networks with digitally stored synapse strengths. We present a novel technique for manipulating bipolar inputs based on an analog two's complements method and an accurate current rectifier...

  17. High dynamic range isotope ratio measurements using an analog electron multiplier

    Czech Academy of Sciences Publication Activity Database

    Williams, P.; Lorinčík, Jan; Franzreb, K.; Herwig, R.

    2013-01-01

    Roč. 45, č. 1 (2013), s. 549-552 ISSN 0142-2421 R&D Projects: GA MŠk ME 894 Institutional support: RVO:67985882 Keywords : Isotope ratios * electron multiplier * dynamic range Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.393, year: 2013

  18. Predicting influenza antigenicity from Hemagglutintin sequence data based on a joint random forest method.

    Science.gov (United States)

    Yao, Yuhua; Li, Xianhong; Liao, Bo; Huang, Li; He, Pingan; Wang, Fayou; Yang, Jiasheng; Sun, Hailiang; Zhao, Yulong; Yang, Jialiang

    2017-05-08

    Timely identification of emerging antigenic variants is critical to influenza vaccine design. The accuracy of a sequence-based antigenic prediction method relies on the choice of amino acids substitution matrices. In this study, we first compared a comprehensive 95 substitution matrices reflecting various amino acids properties in predicting the antigenicity of influenza viruses by a random forest model. We then proposed a novel algorithm called joint random forest regression (JRFR) to jointly consider top substitution matrices. We applied JRFR to human H3N2 seasonal influenza data from 1968 to 2003. A 10-fold cross-validation shows that JRFR outperforms other popular methods in predicting antigenic variants. In addition, our results suggest that structure features are most relevant to influenza antigenicity. By restricting the analysis to data involving two adjacent antigenic clusters, we inferred a few key amino acids mutation driving the 11 historical antigenic drift events, pointing to experimentally validated mutations. Finally, we constructed an antigenic cartography of all H3N2 viruses with hemagglutinin (the glycoprotein on the surface of the influenza virus responsible for its binding to host cells) sequence available from NCBI flu database, and showed an overall correspondence and local inconsistency between genetic and antigenic evolution of H3N2 influenza viruses.

  19. KAJIAN EFEK MULTIPLIER PRODUK UNGGULAN BERBASIS KLUSTER UKM PENGOLAHAN IKAN ASAP

    Directory of Open Access Journals (Sweden)

    Yusmar Ardhi Hidayat

    2015-05-01

    Full Text Available The purpose of this research are to analyze scale of production of leading commodities and multiplier effect of cultivation and smoked fish in Wonosari, Bonang Demak. This research applies census method in collecting data from all business unit which identified as leading commodities in Wirosari Village, Bonang, Demak Regency. Regarding survey conducted, there are 18 catfish breeders and 49 smoked fish small business used as respondent. Primary data used in this research are rate of production in basis goods, land area, capital, raw materials, manpower, and income multiplier. To support empirical discussion, tools of analysis used in this research are descriptive statistics and income multiplier. Results of this research are primary commodities in Wonosari Village are smoked fish and fresh cat fish. Total production of smoked fish reaches 6.4 Ton each day for with type of smoked fish such as river cat fish, tongkol, sting-ray, cat fish, and other river fish. Meanwhile total production of catfish breeding reaches 105 Ton in first harvest after 2-3 months. Based on that number, smoked fish business promise higher profit than profits catfish breeding. Tujuan penelitian ini adalah menganalisis tingkat produksi dan efek multiplier produk unggulan budidaya dan pengasapan ikan di Desa Wonosari, Bonang Kabupaten Demak. Penelitian mengunakan metode sensus dengan mencari data dari semua unit usaha yang merupakan produk unggulan di Desa Wirosari, Bonang Kecamatan Demak. Responden yang diperoleh sejumlah 18 pembudidaya ikan dan 49 usaha pengasapan ikan. Data primer yang akan digunakan yaitu data jumlah produksi komoditas unggulan, luas lahan, jumlah modal, bahan baku, tenaga kerja, dan multiplier pendapatan. Alat analisis yang digunakan dalam penelitian ini adalah statistik deskriptif, dan indeks multiplier pendapatan. Hasil penelitian menunjukkan bahwa komoditas unggulan Desa Wonosari Kecamatan Bonang Kabupaten Demak adalah Ikan Asap dan Budidaya Ikan Lele

  20. Modeling Algorithms in SystemC and ACL2

    Directory of Open Access Journals (Sweden)

    John W. O'Leary

    2014-06-01

    Full Text Available We describe the formal language MASC, based on a subset of SystemC and intended for modeling algorithms to be implemented in hardware. By means of a special-purpose parser, an algorithm coded in SystemC is converted to a MASC model for the purpose of documentation, which in turn is translated to ACL2 for formal verification. The parser also generates a SystemC variant that is suitable as input to a high-level synthesis tool. As an illustration of this methodology, we describe a proof of correctness of a simple 32-bit radix-4 multiplier.

  1. Antigenic relationships among four herpesviruses.

    Science.gov (United States)

    Blue, W T; Plummer, G

    1973-06-01

    Common viral antigens were detected, by fluorescent-antibody studies, in cells infected with herpes simplex virus 1, squirrel monkey herpesvirus 1, bovine rhinotracheitis, and equine abortion viruses. The two primate viruses showed slight cross-neutralization.

  2. HLA-B27 antigen

    Science.gov (United States)

    Human leukocyte antigen B27; Ankylosing spondylitis-HLA; Psoriatic arthritis-HLA; Reactive arthritis-HLA ... Erythrocyte sedimentation rate ( ESR ) Rheumatoid factor X-rays HLA testing is also used to match donated tissue ...

  3. DO PUBLIC AND PRIVATE DEBT LEVELS AFFECT THE SIZE OF FISCAL MULTIPLIERS?

    Directory of Open Access Journals (Sweden)

    Chairul Adi

    2017-09-01

    Full Text Available This paper investigates the effectiveness of fiscal policies – as measured by the impact and cumulative multipliers – and how they interact with public and private debt. Harnessing the moderated panel regression approach, based on the yearly data set of several economies during the period from 1996 to 2012, the analysis is focused on the impact of spending-and-revenue-based fiscal policies on economic growth and how these fiscal instruments interact with public and private indebtedness. The result of spending stimuli advocates the basic Keynesian theory. An increase in public expenditures contemporaneously generates a positive multiplier, of around 0.29 – 0.44 and around 0.45 – 0.58 during two years. Decomposing the expenditures into their elements, this paper documents a stronger impact from public investment than that from government purchases. On the other hand, the revenue stimuli seem to follow the Ricardian Equivalence Hypothesis (REH, arguing that current tax cuts are inconsequential. The impact and cumulative multipliers for this fiscal instrument have mixed results, ranging from -0.21 to 0.05 and -0.26 to 0.06, respectively. Moreover, no robust evidence is found to support the argument that government debt moderates the effectiveness of fiscal policies. The size of the multipliers for both spending and revenue policies remain constant with the level of public debt. On the other hand, private debt appears to show a statistically significant moderating effect on spending stimuli. Its impact on spending multipliers, however, is economically insignificant. The moderation effect of private debt on the revenue stimuli does not seem to exist. Finally, this paper documents that both public and private debt exhibit a negative and statistically significant estimation for economic output.

  4. Natural selection promotes antigenic evolvability.

    Science.gov (United States)

    Graves, Christopher J; Ros, Vera I D; Stevenson, Brian; Sniegowski, Paul D; Brisson, Dustin

    2013-01-01

    The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide an experimentally tractable system to test whether natural selection has favored mechanisms that increase evolvability. Many antigenic variation systems consist of paralogous unexpressed 'cassettes' that recombine into an expression site to rapidly alter the expressed protein. Importantly, the magnitude of antigenic change is a function of the genetic diversity among the unexpressed cassettes. Thus, evidence that selection favors among-cassette diversity is direct evidence that natural selection promotes antigenic evolvability. We used the Lyme disease bacterium, Borrelia burgdorferi, as a model to test the prediction that natural selection favors amino acid diversity among unexpressed vls cassettes and thereby promotes evolvability in a primary surface antigen, VlsE. The hypothesis that diversity among vls cassettes is favored by natural selection was supported in each B. burgdorferi strain analyzed using both classical (dN/dS ratios) and Bayesian population genetic analyses of genetic sequence data. This hypothesis was also supported by the conservation of highly mutable tandem-repeat structures across B. burgdorferi strains despite a near complete absence of sequence conservation. Diversification among vls cassettes due to natural selection and mutable repeat structures promotes long-term antigenic evolvability of VlsE. These findings provide a direct demonstration that molecular mechanisms that enhance evolvability of surface antigens are an evolutionary adaptation. The molecular evolutionary processes identified here can serve as a model for the evolution of antigenic evolvability in many pathogens which utilize similar strategies to establish chronic infections.

  5. Epicutaneous sensitization with protein antigen

    Directory of Open Access Journals (Sweden)

    I-Lin Liu

    2012-12-01

    Full Text Available In the past few decades there has been a progressive understanding that epicutaneous sensitization with protein antigen is an important sensitization route in patients with atopic dermatitis. A murine protein-patch model has been established, and an abundance of data has been obtained from experiments using this model. This review discusses the characteristics of epicutaneous sensitization with protein antigen, the induced immune responses, the underlying mechanisms, and the therapeutic potential.

  6. On bifurcations of a system of cubic differential equations with an integrating multiplier singular along a second-order curve

    Directory of Open Access Journals (Sweden)

    Aleksandr Alekseev

    2015-07-01

    Full Text Available We establish necessary and sufficient conditions for existence of an integrating multiplier of a special form for systems of two cubic differential equations of the first order. We further study bifurcations of such systems with the change of parameters of their integrating multipliers.

  7. Analysis and prediction of area- and energy-consumption of optimized polynomial multipliers in hardware for arbitrary GF(2{sup n}) for elliptic curve cryptography; Analyse und Vorhersage des Flaechen- und Energieverbrauches-optimaler Hardware Polynom-Multiplizierer fuer GF(2{sup n}) fuer elliptische Kurven Kryptographie

    Energy Technology Data Exchange (ETDEWEB)

    Dyka, Zoya

    2012-04-13

    During recent years elliptic curve cryptography (ECC) has gained significant attention especially for devices with scarce resources such as wireless sensor nodes. Hardware implementations are considered to be the key enabler for using ECC on this class of devices. Out of the operations needed to execute ECC the polynomial multiplication is the one which is investigated most since it is one of the most complex field operations and executed very often. The majority of research papers focuses on reducing the number of partial- multiplications while neglecting the increased effort for additions of the partial products. This thesis investigates how the latter can be optimized. A reduction of additions can be achieved by using pre-defined processing sequences for summing up partial products. In this work a method to find the optimized processing sequence is presented. It is applied to 10 multiplication methods of polynomials over GF(2{sup n}). For example when applied to the generalized Karatsuba multiplication [18] the optimized processing sequence saves up to 39 per cent of XOR-gates in average for polynomials with a length up to 600 bits. In addition it is known that combining different multiplication methods reduced the total complexity of the multiplier. For example using the classical MM for calculation of small partial products in combination with other MMs can improve chip-parameters of the resulting multipliers. An optimal combination of several multiplication approaches for which the optimized processing sequence of XOR-operations is used reduces the area and energy consumption of the resulting multiplier significantly. This work presents an algorithm to determine the optimal combination of multiplication methods with pre-defined processing sequences for hardware implementation of an highly efficient polynomial multiplier in GF(2{sup n}). The combinations determined by this algorithm save in average 12 % of the chip-area for polynomials with a length up to 600

  8. Leakage Power Reduction with Various IO Standards and Dynamic Voltage Scaling in Vedic Multiplier on Virtex-6 FPGA

    DEFF Research Database (Denmark)

    Pandey, Bishwajeet; Rehman, M. Atiqur; Hussain, Dil muhammed Akbar

    2016-01-01

    , SSTL and LVCMOS family respectively. Device static power and design static power are two types of static power dissipation. Device static power is also known as Leakage power when the device is on but not configured. Design static power is power dissipation when bit file of design is downloaded on FPGA......The 8-bit design is able to process 256 times input combination in compare to 4-bit vedic multiplier, using approximates 6 times basic elements, 2 times IO buffers, approximate 1.5 times total power dissipation. HSTL_I_12, SSTL18_I and LVCMOS12 are the most energy efficient IO standards in HSTL...... but there is no switching activity. Design static power dissipation of 8-bit Vedic multiplier is almost double of design static power dissipation of 4-bit Vedic multiplier. Device static (leakage) power dissipation of 8-bit Vedic multiplier is almost equal to device static power dissipation of 4-bit Vedic multiplier on 40...

  9. EXPERIMENTAL COMPARISON OF HOMODYNE DEMODULATION ALGORITHMS FOR PHASE FIBER-OPTIC SENSOR

    Directory of Open Access Journals (Sweden)

    M. N. Belikin

    2015-11-01

    Full Text Available Subject of Research. The paper presents the results of experimental comparative analysis of homodyne demodulation algorithms based on differential cross multiplying method and on arctangent method under the same conditions. The dependencies of parameters for the output signals on the optical radiation intensity are studied for the considered demodulation algorithms. Method. The prototype of single fiber optic phase interferometric sensor has been used for experimental comparison of signal demodulation algorithms. Main Results. We have found that homodyne demodulation based on arctangent method provides greater (by 7 dB at average signal-to-noise ratio of output signals over the frequency band of acoustic impact from 100 Hz to 500 Hz as compared to differential cross multiplying algorithms. We have demonstrated that no change in the output signal amplitude occurs for the studied range of values of the optical pulses amplitudes. Obtained results indicate that the homodyne demodulation based on arctangent method is most suitable for application in the phase fiber-optic sensors. It provides higher repeatability of their characteristics than the differential cross multiplying algorithm. Practical Significance. Algorithms of interferometric signals demodulation are widely used in phase fiber-optic sensors. Improvement of their characteristics has a positive effect on the performance of such sensors.

  10. Parallel algorithms

    CERN Document Server

    Casanova, Henri; Robert, Yves

    2008-01-01

    ""…The authors of the present book, who have extensive credentials in both research and instruction in the area of parallelism, present a sound, principled treatment of parallel algorithms. … This book is very well written and extremely well designed from an instructional point of view. … The authors have created an instructive and fascinating text. The book will serve researchers as well as instructors who need a solid, readable text for a course on parallelism in computing. Indeed, for anyone who wants an understandable text from which to acquire a current, rigorous, and broad vi

  11. Enhancing shelf life of minimally processed multiplier onion using silicone membrane.

    Science.gov (United States)

    Naik, Ravindra; Ambrose, Dawn C P; Raghavan, G S Vijaya; Annamalai, S J K

    2014-12-01

    The aim of storage of minimal processed product is to increase the shelf life and thereby extend the period of availability of minimally processed produce. The silicone membrane makes use of the ability of polymer to permit selective passage of gases at different rates according to their physical and chemical properties. Here, the product stored maintains its own atmosphere by the combined effects of respiration process of the commodity and the diffusion rate through the membrane. A study was undertaken to enhance the shelf life of minimally processed multiplier onion with silicone membrane. The respiration activity was recorded at a temperature of 30 ± 2 °C (RH = 60 %) and 5 ± 1 °C (RH = 90 %). The respiration was found to be 23.4, 15.6, 10 mg CO2kg(-1)h(-1) at 5 ± 1 °C and 140, 110, 60 mg CO2kg(-1) h(-1) at 30 ± 2° for the peeled, sliced and diced multiplier onion, respectively. The respiration rate for the fresh multiplier onion was recorded to be 5, 10 mg CO2kg(-1) h(-1) at 5 ± 1 °C and 30 ± 1 ° C, respectively. Based on the shelf life studies and on the sensory evaluation, it was found that only the peeled multiplier onion could be stored. The sliced and diced multiplier onion did not have the required shelf life. The shelf life of the multiplier onion in the peel form could be increased from 4-5 days to 14 days by using the combined effect of silicone membrane (6 cm(2)/kg) and low temperature (5 ± 1 °C).

  12. Features of destruction of solids by laser radiation in process of formation of multiply charged ions

    International Nuclear Information System (INIS)

    Bedilov, R.M.; Bedilov, M.R.; Sabitov, M.M.; Matnazarov, A.; Niyozov, B.

    2004-01-01

    Full text: It is known, under interaction of laser radiation with solid surface a power density q > 0.01 W/cm 2 are observed destruction of a solid and issue of electrons, ions, neutrals, neutrons, plasmas, and also radiation in a wide ranges of a spectra. Despite of a plenty of works, devoted to study of processes of interaction, the studies of feature of destruction of solids by laser beam in process of formation multiply charged ions are insufficiently investigated. The results of study feature of destruction of solids by laser radiation in process of formation multiply charged ions are given in this work. In our experiments, we used the mass spectrometer with single-channel laser radiation. The laser installation had the following parameters: a power density of laser radiation q=(0.1-50) GW/cm 2 ; the angle of incidence a=18 deg. to the target surface Al, (W). It was obtained experimentally dynamics of morphology of destruction and also mass - charge and energy spectra of multiply charged ions formed under interaction of laser radiation with Al (W) in the intensity range q=(0.1-50) GW/cm 2 . These studies showed features of destruction Al(W) by laser radiation, i.e. invariable of value evaporation mass from a surface of a solid increase as the laser intensity q. But thus temperature a pair increases in accordance with increase of flow density of a laser radiation. Increase of temperature the pair gives in formation of multiply charged plasma. It is typical that, as q of the laser increases the maximum charge number of ions in laser plasma considerably increase and their energy spectra extend toward higher energies. For example, under q=0.1 GW/cm 2 and 50 GW/cm 2 the maximum charge number of ions Al (W) are equal to Z max = 1 and 7, respectively. From the experimental data obtained, we can conclude that, the formed multiply charged plasma practically completely absorption laser radiation and 'shielding' a target surface for various metals at power densities

  13. A Newton Algorithm for Multivariate Total Least Squares Problems

    Directory of Open Access Journals (Sweden)

    WANG Leyang

    2016-04-01

    Full Text Available In order to improve calculation efficiency of parameter estimation, an algorithm for multivariate weighted total least squares adjustment based on Newton method is derived. The relationship between the solution of this algorithm and that of multivariate weighted total least squares adjustment based on Lagrange multipliers method is analyzed. According to propagation of cofactor, 16 computational formulae of cofactor matrices of multivariate total least squares adjustment are also listed. The new algorithm could solve adjustment problems containing correlation between observation matrix and coefficient matrix. And it can also deal with their stochastic elements and deterministic elements with only one cofactor matrix. The results illustrate that the Newton algorithm for multivariate total least squares problems could be practiced and have higher convergence rate.

  14. Human sensitization to Ganoderma antigen.

    Science.gov (United States)

    Tarlo, S M; Bell, B; Srinivasan, J; Dolovich, J; Hargreave, F E

    1979-07-01

    Continuous air sampling with a Hirst volumetric spore trap over 3 yr has identified basidiospores of Ganoderma applanatum, a bracket fungus, as the most numerous fungal spores in two southern Ontario locations. The particle size is small and the calculated total spore mass approximates that of the spores of Cladosporium and Alternaria. Extracts of Ganoderma applanatum bracket fungus and spores in w/v, 1:10 concentration were prepared after collection of samples of the fungus from local woods. Skin prick tests with the extracts were performed in 294 consecutive children and adults attending two chest/allergy clinics. Of these patients, 182 (61.9%) reacted to 1 or more of the common inhalant allergen extracts and 24 (8.2%) reacted to Ganoderma antigen. There was no consistent relationship between reactivity to Ganoderma antigen and any of the common inhaled allergens. IgE-dependent sensitization to Ganoderma was confirmed by the radioallergosorbent test (RAST). Rabbit antisera to Ganoderma antigen preparations did not appear to cross-react with preparations of the various clinically important allergens. The findings indicate that Ganoderma antigen is commonly encountered, can induce human sensitization, and has unique antigenicity among common allergens of clinical importance.

  15. Registration characteristics of neutral particles with power 0.6 - 2.0 keV channel electron multiplier with funnel

    Science.gov (United States)

    Gruntman, M. A.; Kalinin, A. P.

    1978-01-01

    Operating a channel electron multiplier with a VEU-6 funnel shaped opening is studied. Different procedures were used when recording neutral particles. The results obtained make it possible to optimally use the multiplier in actual physical studies.

  16. Post-2008 Brazilian fiscal policy: an interpretation through the analysis of fiscal multipliers

    Directory of Open Access Journals (Sweden)

    Celso José Costa Junior

    Full Text Available Abstract The global crisis that erupted in 2007 led many countries to embark on countercyclical fiscal policies as a way to cushion the blow of a depressed aggregate demand. Advocates of discretionary measures emphasize that fiscal policy can indeed stimulate the economy. The main goal of this work is to assess whether the fiscal policies pursued by the Brazilian government in the aftermath of the 2008 crisis, succeeded in bringing the economy back on track in a sustainable fashion. To this end, the fiscal multipliers of five different shocks are studied in a small open-economy New Keynesian framework. Our results point to the government spending and public investment as the most effective fiscal tools for combating the crisis. However, the highest fiscal multiplier turned out to be the one associated with excise tax reductions.

  17. Preconditioned alternating direction method of multipliers for inverse problems with constraints

    Science.gov (United States)

    Jiao, Yuling; Jin, Qinian; Lu, Xiliang; Wang, Weijie

    2017-02-01

    We propose a preconditioned alternating direction method of multipliers (ADMM) to solve linear inverse problems in Hilbert spaces with constraints, where the feature of the sought solution under a linear transformation is captured by a possibly non-smooth convex function. During each iteration step, our method avoids solving large linear systems by choosing a suitable preconditioning operator. In case the data is given exactly, we prove the convergence of our preconditioned ADMM without assuming the existence of a Lagrange multiplier. In case the data is corrupted by noise, we propose a stopping rule using information on noise level and show that our preconditioned ADMM is a regularization method; we also propose a heuristic rule when the information on noise level is unavailable or unreliable and give its detailed analysis. Numerical examples are presented to test the performance of the proposed method.

  18. On-Chip Power-Combining for High-Power Schottky Diode-Based Frequency Multipliers

    Science.gov (United States)

    Chattopadhyay, Goutam; Mehdi, Imran; Schlecht, Erich T.; Lee, Choonsup; Siles, Jose V.; Maestrini, Alain E.; Thomas, Bertrand; Jung, Cecile D.

    2013-01-01

    A 1.6-THz power-combined Schottky frequency tripler was designed to handle approximately 30 mW input power. The design of Schottky-based triplers at this frequency range is mainly constrained by the shrinkage of the waveguide dimensions with frequency and the minimum diode mesa sizes, which limits the maximum number of diodes that can be placed on the chip to no more than two. Hence, multiple-chip power-combined schemes become necessary to increase the power-handling capabilities of high-frequency multipliers. The design presented here overcomes difficulties by performing the power-combining directly on-chip. Four E-probes are located at a single input waveguide in order to equally pump four multiplying structures (featuring two diodes each). The produced output power is then recombined at the output using the same concept.

  19. Effects of layer-multiplying and interface on the content of β-transcrystallization in PP

    Science.gov (United States)

    Lei, Fan; Li, Jiang; Guo, Shaoyun

    2015-05-01

    The alternating multilayered polypropylene (PP layer)/β-nucleating agent filled-polypropylene (β-PP layer) were prepared through layer-multiplying extrusion combined with an assembly of layer-multiplying elements (LM Es). The content of β-crystal was firstly evaluated by differential scanning calorimetry (DSC), which indicated that the relative amount of the β-crystal increased from 38.67% to 81.22% with the increase of layer numbers from 2-layer to 128-layer. It was well consistent with the results of X-ray diffraction (XRD). The morphology observation of β-crystal by polarizing microscope (POM) revealed that the closely packed nuclei in the interface could induce numerous β-transcrystallization in pure PP layer due to the confinement effect. The non-isothermal crystallization kinetic analysis via Mozhishen's methods manifested that the crystallization rate was greatly enhanced by the augment of the layered interface.

  20. Time-resolved PHERMEX image restorations constrained with an additional multiply-exposed image

    International Nuclear Information System (INIS)

    Kruger, R.P.; Breedlove, J.R. Jr.; Trussell, H.J.

    1978-06-01

    There are a number of possible industrial and scientific applications of nanosecond cineradiographs. Although the technology exists to produce closely spaced pulses of x rays for this application, the quality of the time-resolved radiographs is severely limited. The limitations arise from the necessity of using a fluorescent screen to convert the transmitted x rays to light and then using electro-optical imaging systems to gate and to record the images with conventional high-speed cameras. It has been proposed that, in addition to the time-resolved images, a conventional multiply exposed radiograph be obtained. This report uses both PHERMEX and conventional photographic simulations to demonstrate that the additional information supplied by the multiply exposed radiograph can be used to improve the quality of digital image restorations of the time-resolved pictures over what could be achieved with the degraded images alone

  1. A new level-shifting structure with multiply metal rings by divided RESURF technique

    International Nuclear Information System (INIS)

    Liu Jizhi; Chen Xmgbi

    2009-01-01

    A new structure of a lateral n-MOST and a new level-shifting structure with multiply metal rings (MMRs) by divided RESURF technique have been proposed. The device and electrical performances of the structure are analyzed and simulated by MEDICI. In comparison to the level-shifting structure with multiply floating field plates (MFFPs) used before, the structure stated here improves the reliability and diminishes the voltage difference between the voltage of the power supply of the high-side gate driver and the voltage of the output terminal of the level-shifting structure, which is also that of the input terminal of the high-side gate driver. The maximal voltage difference of the level-shifting structure in this paper is 30% lower than that used before. Therefore, good voltage isolation and current isolation are obtained. The structure can be used in the level-shifting circuit of various applications.

  2. Enhanced fuel production in thorium/lithium hybrid blankets utilizing uranium multipliers

    International Nuclear Information System (INIS)

    Pitulski, R.H.

    1979-10-01

    A consistent neutronics analysis is performed to determine the effectiveness of uranium bearing neutron multiplier zones on increasing the production of U 233 in thorium/lithium blankets for use in a tokamak fusion-fission hybrid reactor. The nuclear performance of these blankets is evaluated as a function of zone thicknesses and exposure by using the coupled transport burnup code ANISN-CINDER-HIC. Various parameters such as U 233 , Pu 239 , and H 3 production rates, the blanket energy multiplication, isotopic composition of the fuels, and neutron leakages into the various zones are evaluated during a 5 year (6 MW.y.m -2 ) exposure period. Although the results of this study were obtained for a tokomak magnetic fusion device, the qualitative behavior associated with the use of the uranium bearing neutron multiplier should be applicable to all fusion-fission hybrids

  3. Effect of cooling on the efficiency of Schottky varactor frequency multipliers at millimeter waves

    Science.gov (United States)

    Louhi, Jyrki; Raiesanen, Antti; Erickson, Neal

    1992-01-01

    The efficiency of the Schottky diode multiplier can be increased by cooling the diode to 77 K. The main reason for better efficiency is the increased mobility of the free carriers. Because of that the series resistance decreases and a few dB higher efficiency can be expected at low input power levels. At high output frequencies and at high power levels, the current saturation decreases the efficiency of the multiplication. When the diode is cooled the maximum current of the diode increases and much more output power can be expected. There are also slight changes in the I-V characteristic and in the diode junction capacitance, but they have a negligible effect on the efficiency of the multiplier.

  4. Effects of layer-multiplying and interface on the content of β-transcrystallization in PP

    International Nuclear Information System (INIS)

    Lei, Fan; Li, Jiang; Guo, Shaoyun

    2015-01-01

    The alternating multilayered polypropylene (PP layer)/β-nucleating agent filled-polypropylene (β-PP layer) were prepared through layer-multiplying extrusion combined with an assembly of layer-multiplying elements (LM Es). The content of β-crystal was firstly evaluated by differential scanning calorimetry (DSC), which indicated that the relative amount of the β-crystal increased from 38.67% to 81.22% with the increase of layer numbers from 2-layer to 128-layer. It was well consistent with the results of X-ray diffraction (XRD). The morphology observation of β-crystal by polarizing microscope (POM) revealed that the closely packed nuclei in the interface could induce numerous β-transcrystallization in pure PP layer due to the confinement effect. The non-isothermal crystallization kinetic analysis via Mozhishen’s methods manifested that the crystallization rate was greatly enhanced by the augment of the layered interface

  5. Fit Indexes, Lagrange Multipliers, Constraint Changes and Incomplete Data in Structural Models.

    Science.gov (United States)

    Bentler, P M

    1990-04-01

    Certain aspects of model modification and evaluation are discussed, with an emphasis on some points of view that expand upon or may differ from Kaplan (1990). The usefulness of BentlerBonett indexes is reiterated. When degree of misspecification can be measured by the size of the noncentrality parameter of a x[SUP2] distribution, the comparative fit index provides a useful general index of model adequacy that does not require knowledge of sourees of misspecification. The dependence of the Lagrange Multiplier X[SUP2] statistic on both the estimated multiplier parameter and estimated constraint or parameter change is discussed. A sensitivity theorem that shows the effects of unit change in constraints on model fit is developed for model modification in structural models. Recent incomplete data methods, such as those developed by Kaplan and his collaborators, are extended to be applicable in a wider range of situations.

  6. A convolution type characterization for Lp - multipliers for the Heisenberg group

    Directory of Open Access Journals (Sweden)

    R. Radha

    2007-01-01

    Full Text Available It is well known that if m is an Lp - multiplier for the Fourier transform on ℝn(1

  7. The multiplier accelerator theory in the study of municipal-level investment

    OpenAIRE

    Kazakova, Oxana B.; Kuzminykh, Natalia A.

    2018-01-01

    In our research we specially adapted the multiplier accelerator approach for analysis of investment processes on the municipal level. We analyzed the databases of municipalities of the Bashkortostan Republic and found a one-year lag and ratchet effects in the development of investment processes, which manifested themselves through steady rates of growth in the volumes of shipped goods and services in these areas while the amount of investment was declining. Excessively high values of the inve...

  8. Regional multipliers of social accounting matrix and the effective eradication of poverty

    OpenAIRE

    Wannaphong Durongkaveroj and Rossarin Osathanunkul; Rossarin Osathanunkul

    2013-01-01

    Halving poverty became a global responsibility. As decreased poverty was typically related with an increased income, policies relevant to economic growth had been widely implemented throughout all regions. The purpose of this study was to simulate the effects of exogenously macroeconomic shocks on regional poverty through SAM multiplier in various groups of developing country around the world. The study revealed that to eradicate poverty in each region required exogenous shock or income injec...

  9. Proton and hydrogen atom detection efficiency of resistance strip magnetic electron multiplier particle-counting system

    Energy Technology Data Exchange (ETDEWEB)

    Wehrenberg, P.J.; Clark, K.C.

    1976-10-01

    The absolute detection efficiency for protons and for hydrogen atoms in the energy range 5--60 keV is determined for a resistance strip magnetic electron multiplier particle-counting system. Significant history-dependent gain variations are discussed. The detector system is suitable for use in coincidence experiments requiring particle-counting rates to 1.0 MHz and timing accuracies of 3.0 nsec. (AIP)

  10. Ionizing device comprising a microchannel electron multiplier with secondary electron emission

    International Nuclear Information System (INIS)

    Chalmeton, Vincent.

    1974-01-01

    The present invention relates to a ionizing device comprising a microchannel electron multiplier involving secondary electron emission as a means of ionization. A system of electrodes is used to accelerate said electrons, ionize the gas and extract the ions from thus created plasma. Said ionizer is suitable for bombarding the target in neutron sources (target of the type of nickel molybdenum coated with tritiated titanium or with a tritium deuterium mixture) [fr

  11. Relations between bilinear multipliers on Rn,Tn Rn,Tn Rn,Tn and Zn

    Indian Academy of Sciences (India)

    Since then the study of bilinear multiplier operators which commute with simultaneous translations have attracted a great deal of ... Unlike in the linear case, the boundedness of the symbol ψC is not known. In this article we will be dealing with .... For the converse, let ψ ∈ M p3 p1,p2 (Z). For f, g ∈ C∞ c (R), we have.

  12. Isometric multipliers of Lp(G, X) Lp(G, X) Lp(G, X)

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Abstract. Let G be a locally compact group with a fixed right Haar measure and X a separable Banach space. Let Lp(G, X) be the space of X-valued measurable functions whose norm-functions are in the usual Lp . A left multiplier of Lp(G, X) is a bounded linear operator on Lp(G, X) which commutes with all left translations.

  13. High Speed Linear Pipeline Multiplier for Signed-Unsigned Number Operating at 20 GHz

    Directory of Open Access Journals (Sweden)

    Ravindra P Rajput

    2015-12-01

    Full Text Available In this paper we proposed an 8 × 8 synchronous pipeline multiplier for signed-unsigned number operating at 20 GHz. This multiplier is designed using three stage pipelined operation. During first stage of the pipelined operation all the 53 bits of the partial products are generated by the Multiplexer based Modified Booth Encoder (MMBE technique and lathed into the 53 bit register. During second stage of the pipelined operation, the five partial products are reduced to the array of only two rows by using VCA as the PPRT and are latched into the 32 bit register. During third stage of pipeline operation the final product is obtained by using the CLCSA as the CPA and latched into the 16 bit register. The pipe stage fills up in three clock cycles, and once the pipeline is filled up, then every clock cycle the new product of 8-bit signed unsigned number is obtained. The delay measured of MMBE is 0.023 ns, VCA is 0.036 ns and CLCSA is 0.050 ns. Since the maximum delay of the pipeline stage has been used as the clock signal, therefore the delay of CLCSA stage has been used as the pipeline clock signal and hence each pipeline stage is operated with frequency of 20 GHz. Experimental results has been obtained using the 45 nm CMOS technology for 8 × 8 pipelined multiplier. The delay, area and power consumption has been measured. Comparison of results shows that our proposed three stage pipeline multiplier has been improved in delay by 26 %, area reduced by 53 % and power dissipation saved by 54 %.

  14. Trimetallic nanostructures: the case of AgPd/Pt multiply twinned nanoparticles

    OpenAIRE

    Khanal, Subarna; Bhattarai, Nabraj; Velázquez-Salazar, J. Jesús; Bahena, Daniel; Soldano, German; Ponce, Arturo; Mariscal, Marcelo M.; Mejía-Rosales, Sergio; José-Yacamán, Miguel

    2013-01-01

    We report the synthesis, structural characterization, and atomistic simulations of AgPd/Pt trimetallic (TM) nanoparticles. Two types of structure were synthesized using a relatively facile chemical method: multiply twinned core-shell, and hollow particles. The nanoparticles were small in size, with an average diameter of 11 nm and a narrow distribution, and their characterization by aberration corrected scanning transmission electron microscopy allowed us to probe the structure of the particl...

  15. Proposal for multi-anode photo multiplier tubes as photo detectors for the LHCb RICH

    CERN Document Server

    Muheim, F; Katvars, S; Wotton, S; Albrecht, E; Bernet, R; Eisenhardt, S; Muheim, F; Playfer, S; Cuneo, S; Petrolini, A; Sannino, M; Easo, S; Halley, A; Barber, G; Duane, A; Price, D; Simmons, B; Websdale, D; Calvi, M; Matteuzzi, C; Paganoni, M; Bibby, J; Charles, M; Harnew, N; Libby, J; Rademacker, J; Smale, N; Topp-Jorgensen, S; Wilkinson, G; Baker, J; Densham, C; French, M

    2001-01-01

    We propose to use the Multianode Photo Multiplier Tubes (MAPMT) as the photosensitive device for the Ring Imaging Cherenkov (RICH) detector in the LHCb experiment. We demonstrate that MAPMT meet the specifications which are required to perform excellent particle identification of charged tracks over the full acceptance. A baseline design is presented. At the end of 1999 the MAPMT has been selected as backup choice for the photodetectors. We present the implication of this decision on the baseline design.

  16. Understanding the size of the government spending multiplier: It's in the sign

    OpenAIRE

    Barnichon, Régis; Matthes, Christian

    2016-01-01

    Despite intense scrutiny, estimates of the government spending multiplier remain highly uncertain, with values ranging from 0.5 to 2. While an increase in government spending is generally assumed to have the same (mirror-image) effect as a decrease in government spending, we show that relaxing this assumption is important to understand the effects of fiscal policy. Regardless of whether we identify government spending shocks from (i) a narrative approach, or (ii) a timing restr...

  17. The Growth Points of Regional Economy and Regression Estimation for Branch Investment Multipliers

    Directory of Open Access Journals (Sweden)

    Nina Pavlovna Goridko

    2018-03-01

    Full Text Available The article develops the methodology of using investment multipliers to identify growth points for a regional economy. The paper discusses various options for the assessment of multiplicative effects caused by investments in certain sectors of the economy. All calculations are carried out on the example of economy of the Republic of Tatarstan for the period 2005–2015. The instrument of regression modeling using the method of least squares, permits to estimate sectoral and cross-sectoral investment multipliers in the economy of the Republic of Tatarstan. Moreover, this method allows to assess the elasticity of gross output of regional economy and its individual sectors depending on investment in various sectors of the economy. Calculations results allowed to identify three growth points of the economy of the Republic of Tatarstan. They are mining industry, manufacturing industry and construction. The success of a particular industry or sub-industry in a country or a region should be measured not only by its share in macro-system’s gross output or value added, but also by the multiplicative effect that investments in the industry have on the development of other industries, on employment and on general national or regional product. In recent years, the growth of the Russian was close to zero. Thus, it is crucial to understand the structural consequences of the increasing investments in various sectors of the Russian economy. In this regard, the problems solved in the article are relevant for a number of countries and regions with a similar economic situation. The obtained results can be applied for similar estimations of investment multipliers as well as multipliers of government spending, and other components of aggregate demand in various countries and regions to identify growth points. Investments in these growth points will induce the greatest and the most evident increment of the outcome from the macro-system’s economic activities.

  18. Enhanced fuel production in thorium fusion hybrid blankets utilizing uranium multipliers

    International Nuclear Information System (INIS)

    Pitulski, R.H.; Chapin, D.L.; Klevans, E.

    1979-01-01

    The multiplication of 14 MeV D-T fusion neutrons via (n,2n), (n,3n), and fission reactions by 238 U is well known and established. This study consistently evaluates the effectiveness of a depleted (tails) UO 2 multiplier on increasing the production of 233 U and tritium in a thorium/lithium fusion--fission hybrid blanket. Nuclear performance is evaluated as a function of exposure and zone thickness

  19. On the fast response of charnel electron multipliers in coUnting mode operation

    International Nuclear Information System (INIS)

    Belyaevskij, O.A.; Gladyshev, I.L.; Korobochko, Yu.S.; Mineev, V.I.

    1983-01-01

    Dependences of amplitude distribution of pulses at the outlet of channel electron multipliers (CEM) and effectiveness of monitoring on counting rate at different supply voltages are determined. It is shown that the maximUm counting rate of CEM runs into 6x10 5 s -1 at short-term and 10 5 s -1 at long-term operation using monitoring eqUipment with operation threshold of 2.5 mV

  20. Influence of capture to excited states of multiply charged ion beams colliding with small molecules

    International Nuclear Information System (INIS)

    Montenegro, P; Monti, J M; Fojón, O A; Hanssen, J; Rivarola, R D

    2015-01-01

    Electron capture by multiply charged ions impacting on small molecules is theoretically investigated. Particular attention is paid to the case of biological targets. The interest is focused on the importance of the transition to excited final states which can play a dominant role on the total capture cross sections. Projectiles at intermediate and high collision energies are considered. Comparison with existing experimental data is shown. (paper)

  1. Characterisation of Sarcoptes scabiei antigens.

    Science.gov (United States)

    Hejduk, Gloria; Hofstätter, Katja; Löwenstein, Michael; Peschke, Roman; Miller, Ingrid; Joachim, Anja

    2011-02-01

    In pig herds, the status of Sarcoptes scabiei infections is routinely monitored by serodiagnosis. Crude antigen for ELISA is usually prepared from S. scabiei var. canis or other variations and may lead to variations in the outcome of different tests, making assay standardisation difficult. This study was performed to investigate the antigen profiles of S. scabiei, including differences between hydrophilic and more hydrophobic protein fractions, by Western blotting with sera from pigs with defined infection status. Potential cross-reactivity among S. scabiei (var. canis, suis and bovis), Dermatophagoides farinae and Tyrophagus putrescentiae was also analysed. Hydrophobic S. scabiei antigens were detectable in the range of 40-50 kDa, whilst the hydrophilic fraction showed no specific antigenicity. In the hydrophobic fractions of D. farinae and T. putrescentiae, two major protein fractions in a similar size range could be identified, but no cross-reactivity with Sarcoptes-positive sera was detectable. However, examination of the hydrophilic fractions revealed cross-reactivity between Sarcoptes-positive sera and both the house dust mite and the storage mite in the range of 115 and 28/38 kDa. Specific bands in the same range (42 and 48 kDa) could be detected in blots from hydrophobic fractions of all three tested variations of S. scabiei (var. canis, bovis and suis). These results show that there are considerable differences in mange antibody reactivity, including reactions with proteins from free-living mites, which may interfere with tests based on hydrophilic antigens. Further refinement of antigen and the use of specific hydrophobic proteins could improve ELISA performance and standardisation.

  2. Formation of molecules in interstellar clouds from singly and multiply ionized atoms

    International Nuclear Information System (INIS)

    Langer, W.D.; and NASA, Institute for Space Studies, Goddard Space Flight Center, New York)

    1978-01-01

    Soft X-ray and cosmic rays produce multiply ionized atoms which may initiate molecule production in interstellar clouds. This molecule production can occur via ion-molecule reactions with H 2 , either directly from the multiply ionized atom (e.g.,C ++ + H 2 →CH + + H + ), or indirectly from the singly ionized atoms (e.g., N + + H 2 →NH + + H) that are formed from the recombination or charge transfer of the highly ionized atom (e.g., N ++ + e→N + + hv). We investigate the contribution of these reactions to the abundances of carbon-, nitrogen-, and oxygen-bearing molecules in isobaric models of diffuse clouds. In the presence of the average flux estimated for the diffuse soft X-ray background, multiply ionized atoms contribute only minimally (a few percent) to carbon-bearing molecules such as CH. In the neighborhood of diffuse structures or discrete sources, however, where the X-ray flux is enhanced, multiple ionization is considerably more important for molecule production

  3. Design, implementation and performance comparison of multiplier topologies in power-delay space

    Directory of Open Access Journals (Sweden)

    Mansi Jhamb

    2016-03-01

    Full Text Available With the advancements in the semiconductor industry, designing a high performance processor is a prime concern. Multiplier is one of the most crucial parts in almost every digital signal processing applications. This paper addresses the implementation of an 8-bit multiplier design employing CMOS full adder, full adder using Double Pass Transistor (DPL and multioutput carry Lookahead logic (CLA. DPL adder avoids the noise margin problem and speed degradation at low value of supply voltages associated with complementary pass transistor (CPL logic circuits. Multioutput carry lookahead adder leads to significant improvement in the speed of the overall circuitry. The investigation is carried out with simulation runs on HSPICE environment using 90 nm process technology at 25 °C. Finally, the design guidelines are derived to select the most suitable topology for the desired applications. Investigation reveals that multiplier design using multioutput carry lookahead adder proves to be more speed efficient in comparison with the other two considered design strategies.

  4. Inference on the reliability of Weibull distribution with multiply Type-I censored data

    International Nuclear Information System (INIS)

    Jia, Xiang; Wang, Dong; Jiang, Ping; Guo, Bo

    2016-01-01

    In this paper, we focus on the reliability of Weibull distribution under multiply Type-I censoring, which is a general form of Type-I censoring. In multiply Type-I censoring in this study, all units in the life testing experiment are terminated at different times. Reliability estimation with the maximum likelihood estimate of Weibull parameters is conducted. With the delta method and Fisher information, we propose a confidence interval for reliability and compare it with the bias-corrected and accelerated bootstrap confidence interval. Furthermore, a scenario involving a few expert judgments of reliability is considered. A method is developed to generate extended estimations of reliability according to the original judgments and transform them to estimations of Weibull parameters. With Bayes theory and the Monte Carlo Markov Chain method, a posterior sample is obtained to compute the Bayes estimate and credible interval for reliability. Monte Carlo simulation demonstrates that the proposed confidence interval outperforms the bootstrap one. The Bayes estimate and credible interval for reliability are both satisfactory. Finally, a real example is analyzed to illustrate the application of the proposed methods. - Highlights: • We focus on reliability of Weibull distribution under multiply Type-I censoring. • The proposed confidence interval for the reliability is superior after comparison. • The Bayes estimates with a few expert judgements on reliability are satisfactory. • We specify the cases where the MLEs do not exist and present methods to remedy it. • The distribution of estimate of reliability should be used for accurate estimate.

  5. Lower-Order Compensation Chain Threshold-Reduction Technique for Multi-Stage Voltage Multipliers.

    Science.gov (United States)

    Dell' Anna, Francesco; Dong, Tao; Li, Ping; Wen, Yumei; Azadmehr, Mehdi; Casu, Mario; Berg, Yngvar

    2018-04-17

    This paper presents a novel threshold-compensation technique for multi-stage voltage multipliers employed in low power applications such as passive and autonomous wireless sensing nodes (WSNs) powered by energy harvesters. The proposed threshold-reduction technique enables a topological design methodology which, through an optimum control of the trade-off among transistor conductivity and leakage losses, is aimed at maximizing the voltage conversion efficiency (VCE) for a given ac input signal and physical chip area occupation. The conducted simulations positively assert the validity of the proposed design methodology, emphasizing the exploitable design space yielded by the transistor connection scheme in the voltage multiplier chain. An experimental validation and comparison of threshold-compensation techniques was performed, adopting 2N5247 N-channel junction field effect transistors (JFETs) for the realization of the voltage multiplier prototypes. The attained measurements clearly support the effectiveness of the proposed threshold-reduction approach, which can significantly reduce the chip area occupation for a given target output performance and ac input signal.

  6. Lower-Order Compensation Chain Threshold-Reduction Technique for Multi-Stage Voltage Multipliers

    Directory of Open Access Journals (Sweden)

    Francesco Dell’ Anna

    2018-04-01

    Full Text Available This paper presents a novel threshold-compensation technique for multi-stage voltage multipliers employed in low power applications such as passive and autonomous wireless sensing nodes (WSNs powered by energy harvesters. The proposed threshold-reduction technique enables a topological design methodology which, through an optimum control of the trade-off among transistor conductivity and leakage losses, is aimed at maximizing the voltage conversion efficiency (VCE for a given ac input signal and physical chip area occupation. The conducted simulations positively assert the validity of the proposed design methodology, emphasizing the exploitable design space yielded by the transistor connection scheme in the voltage multiplier chain. An experimental validation and comparison of threshold-compensation techniques was performed, adopting 2N5247 N-channel junction field effect transistors (JFETs for the realization of the voltage multiplier prototypes. The attained measurements clearly support the effectiveness of the proposed threshold-reduction approach, which can significantly reduce the chip area occupation for a given target output performance and ac input signal.

  7. Multiplier effects and government assistance to energy megaprojects: An application to Hibernia

    International Nuclear Information System (INIS)

    Feehan, J.P.; Locke, L.W.

    1993-01-01

    Energy megaprojects typically require several years to construct and entail substantial costs. These costs, in the forms of employment, capital equipment and material inputs, are sometimes viewed as benefits. Moreover, the expenditures on these inputs can induce further increases in employment and income. On the basis of these project-specific and induced effects, government assistance is sometimes sought. The very limiting circumstances under which such government aid is justified are described. Multiplier effects only become relevant if private expenditure would not otherwise occur in some form in the economy. There are contractionary multiplier effects associated with the imposition of taxes to finance the project, and so the two opposing forces may be largely offsetting. Government assistance can only be justified in the presence of unemployment, and where the multiplier effects are large. When these criteria are applied to the Hibernia project, it is found that the project does not generate employment and income effects that are large relative to the total expenditure, or even relative to the level of federal government assistance. The job creation argument for the justification of government assistance to the Hibernia project is very weak. 18 refs., 1 tab

  8. Low-order-mode harmonic multiplying gyrotron traveling-wave amplifier in W band

    International Nuclear Information System (INIS)

    Yeh, Y. S.; Chen, C. H.; Yang, S. J.; Lai, C. H.; Lin, T. Y.; Lo, Y. C.; Hong, J. W.; Hung, C. L.; Chang, T. H.

    2012-01-01

    Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) allow for magnetic field reduction and frequency multiplication. To avoid absolute instabilities, this work proposes a W-band harmonic multiplying gyro-TWA operating at low-order modes. By amplifying a fundamental harmonic TE 11 drive wave, the second harmonic component of the beam current initiates a TE 21 wave to be amplified. Absolute instabilities in the gyro-TWA are suppressed by shortening the interaction circuit and increasing wall losses. Simulation results reveal that compared with Ka-band gyro-TWTs, the lower wall losses effectively suppress absolute instabilities in the W-band gyro-TWA. However, a global reflective oscillation occurs as the wall losses decrease. Increasing the length or resistivity of the lossy section can reduce the feedback of the oscillation to stabilize the amplifier. The W-band harmonic multiplying gyro-TWA is predicted to yield a peak output power of 111 kW at 98 GHz with an efficiency of 25%, a saturated gain of 26 dB, and a bandwidth of 1.6 GHz for a 60 kV, 7.5 A electron beam with an axial velocity spread of 8%.

  9. Severity Multipliers as a Methodology to Explore Potential Effects of Climate Change on Stream Bioassessment Programs

    Directory of Open Access Journals (Sweden)

    Sonja C. Jähnig

    2017-04-01

    Full Text Available Given the scientific consensus that climate change is impacting biodiversity, estimates of future climate change effects on stream communities and assessments of potential biases are necessary. Here, we propose a simple technique to approximate changes in invertebrate and fish biomonitoring results. Taxa lists for 60 (invertebrate and 52 (fish sites were each modified by 10 multipliers as stepwise 5% or 10% changes in abundances to simulate potential climate-change severity, reflecting increasing climate change effects. These 10 multipliers were based on the stream zonation preference for invertebrates and the Fish Region Index (FRI values for fish, both reflecting the longitudinal gradient present in river ecosystems. The original and modified taxa lists were analyzed using the standard assessment software for the particular group, followed by analysis of key biomonitoring metrics. For invertebrates, our simulations affected small good quality streams more often negatively while large poor mountain streams showed a tendency to improve. Forty percent of the invertebrate data sites showed a change in the final ecological assessment class when using the multipliers, with the poor quality sites changing more often. For fish, metric changes were variable, but the FRI ratio showed mostly positive responses, i.e., a shift in FRI towards downstream communities. The results are discussed as an example that facilitates the interpretation of potential climate-change effects with varying severity. Further, we discuss the simplified approach and implications for assessment from climate change induced range shifts.

  10. [Farmer's lung antigens in Germany].

    Science.gov (United States)

    Sennekamp, J; Joest, M; Sander, I; Engelhart, S; Raulf-Heimsoth, M

    2012-05-01

    Recent studies suggest that besides the long-known farmer's lung antigen sources Saccharopolyspora rectivirgula (Micropolyspora faeni), Thermoactinomyces vulgaris, and Aspergillus fumigatus, additionally the mold Absidia (Lichtheimia) corymbifera as well as the bacteria Erwinia herbicola (Pantoea agglomerans) and Streptomyces albus may cause farmer's lung in Germany. In this study the sera of 64 farmers with a suspicion of farmer's lung were examined for the following further antigens: Wallemia sebi, Cladosporium herbarum, Aspergillus versicolor, and Eurotium amstelodami. Our results indicate that these molds are not frequent causes of farmer's lung in Germany. © Georg Thieme Verlag KG Stuttgart · New York.

  11. The augmented lagrange multipliers method for matrix completion from corrupted samplings with application to mixed Gaussian-impulse noise removal.

    Science.gov (United States)

    Meng, Fan; Yang, Xiaomei; Zhou, Chenghu

    2014-01-01

    This paper studies the problem of the restoration of images corrupted by mixed Gaussian-impulse noise. In recent years, low-rank matrix reconstruction has become a research hotspot in many scientific and engineering domains such as machine learning, image processing, computer vision and bioinformatics, which mainly involves the problem of matrix completion and robust principal component analysis, namely recovering a low-rank matrix from an incomplete but accurate sampling subset of its entries and from an observed data matrix with an unknown fraction of its entries being arbitrarily corrupted, respectively. Inspired by these ideas, we consider the problem of recovering a low-rank matrix from an incomplete sampling subset of its entries with an unknown fraction of the samplings contaminated by arbitrary errors, which is defined as the problem of matrix completion from corrupted samplings and modeled as a convex optimization problem that minimizes a combination of the nuclear norm and the l(1)-norm in this paper. Meanwhile, we put forward a novel and effective algorithm called augmented Lagrange multipliers to exactly solve the problem. For mixed Gaussian-impulse noise removal, we regard it as the problem of matrix completion from corrupted samplings, and restore the noisy image following an impulse-detecting procedure. Compared with some existing methods for mixed noise removal, the recovery quality performance of our method is dominant if images possess low-rank features such as geometrically regular textures and similar structured contents; especially when the density of impulse noise is relatively high and the variance of Gaussian noise is small, our method can outperform the traditional methods significantly not only in the simultaneous removal of Gaussian noise and impulse noise, and the restoration ability for a low-rank image matrix, but also in the preservation of textures and details in the image.

  12. The augmented lagrange multipliers method for matrix completion from corrupted samplings with application to mixed Gaussian-impulse noise removal.

    Directory of Open Access Journals (Sweden)

    Fan Meng

    Full Text Available This paper studies the problem of the restoration of images corrupted by mixed Gaussian-impulse noise. In recent years, low-rank matrix reconstruction has become a research hotspot in many scientific and engineering domains such as machine learning, image processing, computer vision and bioinformatics, which mainly involves the problem of matrix completion and robust principal component analysis, namely recovering a low-rank matrix from an incomplete but accurate sampling subset of its entries and from an observed data matrix with an unknown fraction of its entries being arbitrarily corrupted, respectively. Inspired by these ideas, we consider the problem of recovering a low-rank matrix from an incomplete sampling subset of its entries with an unknown fraction of the samplings contaminated by arbitrary errors, which is defined as the problem of matrix completion from corrupted samplings and modeled as a convex optimization problem that minimizes a combination of the nuclear norm and the l(1-norm in this paper. Meanwhile, we put forward a novel and effective algorithm called augmented Lagrange multipliers to exactly solve the problem. For mixed Gaussian-impulse noise removal, we regard it as the problem of matrix completion from corrupted samplings, and restore the noisy image following an impulse-detecting procedure. Compared with some existing methods for mixed noise removal, the recovery quality performance of our method is dominant if images possess low-rank features such as geometrically regular textures and similar structured contents; especially when the density of impulse noise is relatively high and the variance of Gaussian noise is small, our method can outperform the traditional methods significantly not only in the simultaneous removal of Gaussian noise and impulse noise, and the restoration ability for a low-rank image matrix, but also in the preservation of textures and details in the image.

  13. Natural selection promotes antigenic evolvability

    NARCIS (Netherlands)

    Graves, C.J.; Ros, V.I.D.; Stevenson, B.; Sniegowski, P.D.; Brisson, D.

    2013-01-01

    The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide

  14. Hybrid Design, Modelling, and Simulation of a 4-Bit Binary Multiplier using Vivado, Simulink, and Kintex-7 FPGA

    Directory of Open Access Journals (Sweden)

    P. Y. Dibal

    2015-08-01

    Full Text Available The design of binary multipliers is a critical aspect of any reliable hardware in computing and computer engineering. In this paper, the design of a 4 bit binary multiplier has been undertaken, starting with a review of the importance of binary multipliers and wide areas of application. The paper then presents the multiplication methodology which involves an accumulator, a full adder, and a control circuit. The accumulator and full adder were designed using VHDL in the Vivado IDE, whereas the control circuit was modelled using the powerful technique of State flow in Simulink. The 4 bit binary multiplier is then modelled and simulated using the combination of Simulink and VHDL. Results obtained from the simulation verified the accuracy of the design methodology.

  15. An Alternative Route to Teaching Fraction Division: Abstraction of Common Denominator Algorithm

    Directory of Open Access Journals (Sweden)

    İsmail Özgür ZEMBAT

    2015-06-01

    Full Text Available From a curricular stand point, the traditional invert and multiply algorithm for division of fractions provides few affordances for linking to a rich understanding of fractions. On the other hand, an alternative algorithm, called common denominator algorithm, has many such affordances. The current study serves as an argument for shifting curriculum for fraction division from use of invert and multiply algorithm as a basis to the use of common denominator algorithm as a basis. This was accomplished with the analysis of learning of two prospective elementary teachers being an illustration of how to realize those conceptual affordances. In doing so, the article proposes an instructional sequence and details it by referring to both the (mathematical and pedagogical advantages and the disadvantages. As a result, this algorithm has a conceptual basis depending on basic operations of partitioning, unitizing, and counting, which make it accessible to learners. Also, when participants are encouraged to construct this algorithm based on their work with diagrams, common denominator algorithm formalizes the work that they do with diagrams.

  16. An alternative route to teaching fraction division: Abstraction of common denominator algorithm

    Directory of Open Access Journals (Sweden)

    İsmail Özgür Zembat

    2015-07-01

    Full Text Available From a curricular stand point, the traditional invert and multiply algorithm for division of fractions provides few affordances for linking to a rich understanding of fractions. On the other hand, an alternative algorithm, called common denominator algorithm, has many such affordances. The current study serves as an argument for shifting curriculum for fraction division from use of invert and multiply algorithm as a basis to the use of common denominator algorithm as a basis. This was accomplished with the analysis of learning of two prospective elementary teachers being an illustration of how to realize those conceptual affordances. In doing so, the article proposes an instructional sequence and details it by referring to both the (mathematical and pedagogical advantages and the disadvantages. As a result, this algorithm has a conceptual basis depending on basic operations of partitioning, unitizing, and counting, which make it accessible to learners. Also, when participants are encouraged to construct this algorithm based on their work with diagrams, common denominator algorithm formalizes the work that they do with diagrams.

  17. A new VLSI complex integer multiplier which uses a quadratic-polynomial residue system with Fermat numbers

    Science.gov (United States)

    Shyu, H. C.; Reed, I. S.; Truong, T. K.; Hsu, I. S.; Chang, J. J.

    1987-01-01

    A quadratic-polynomial Fermat residue number system (QFNS) has been used to compute complex integer multiplications. The advantage of such a QFNS is that a complex integer multiplication requires only two integer multiplications. In this article, a new type Fermat number multiplier is developed which eliminates the initialization condition of the previous method. It is shown that the new complex multiplier can be implemented on a single VLSI chip. Such a chip is designed and fabricated in CMOS-Pw technology.

  18. The effects of multiply ionizing gamma irradiations on the xenobiotic metabolizing system in the liver of rats

    International Nuclear Information System (INIS)

    Zavodnik, L.B.; Buko, V.U.

    2009-01-01

    The aim of the work was the studying the effect of multiply low doses of gamma-irradiation in a total doze 1 and 2 Gy on processes lipid peroxidation and xenobiotics metabolizing in rat liver. It was shown the multiply irradiation causes the expressed activation of lipid peroxidation, by increase of TBARS level and dien conjugates. The system of microsomal oxidations was broken at the same time. (authors)

  19. Concepts and applications for influenza antigenic cartography

    Science.gov (United States)

    Cai, Zhipeng; Zhang, Tong; Wan, Xiu-Feng

    2011-01-01

    Influenza antigenic cartography projects influenza antigens into a two or three dimensional map based on immunological datasets, such as hemagglutination inhibition and microneutralization assays. A robust antigenic cartography can facilitate influenza vaccine strain selection since the antigenic map can simplify data interpretation through intuitive antigenic map. However, antigenic cartography construction is not trivial due to the challenging features embedded in the immunological data, such as data incompleteness, high noises, and low reactors. To overcome these challenges, we developed a computational method, temporal Matrix Completion-Multidimensional Scaling (MC-MDS), by adapting the low rank MC concept from the movie recommendation system in Netflix and the MDS method from geographic cartography construction. The application on H3N2 and 2009 pandemic H1N1 influenza A viruses demonstrates that temporal MC-MDS is effective and efficient in constructing influenza antigenic cartography. The web sever is available at http://sysbio.cvm.msstate.edu/AntigenMap. PMID:21761589

  20. INNOVATIVE STRATEGIES TO IDENTIFY M. TUBERCULOSIS ANTIGENS AND EPITOPES USING GENOME-WIDE ANALYSES

    Directory of Open Access Journals (Sweden)

    Annemieke eGeluk

    2014-06-01

    Full Text Available In view of the fact that only a small part of the Mtb expressome has been explored for identification of antigens capable of activating human T-cell responses, which is critically required for the design of better TB vaccination strategies, more emphasis should be placed on innovative ways to discover new Mtb antigens and explore their function at the several stages of infection. Better protective antigens for TB vaccines are urgently needed, also in view of the disappointing results of the MVA85 vaccine which failed to induce additional protection in BCG vaccinated infants [54]. Moreover, immune responses to relevant antigens may be useful to identify TB-specific biomarker signatures. Here we describe the potency of novel tools and strategies to reveal such Mtb antigens. Using proteins specific for different Mtb infection phases, many new antigens of the latency-associated Mtb DosR regulon as well as Rpf proteins, associated with resuscitating TB, were discovered that were recognized by CD4+ and CD8+ T-cells. Furthermore, by employing MHC binding algorithms and bioinformatics combined with high throughput human T-cell screens and tetramers, HLA-class Ia restricted poly-functional CD8+ T-cells were identified in TB patients. Comparable methods, led to the identification of HLA-E-restricted Mtb epitopes recognized by CD8+ T-cells. A genome-wide unbiased antigen discovery approach was applied to analyse the in vivo Mtb gene expression profiles in the lungs of mice, resulting in the identification of IVE-TB antigens, which are expressed during infection in the lung, the main target organ of Mtb. IVE-TB antigens induce strong T cell responses in long-term latently Mtb infected individuals, and represent an interesting new group of TB antigens for vaccination. In summary, new tools have helped expand our view on the Mtb antigenome involved in human cellular immunity and provided new candidates for TB vaccination.

  1. Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif

    DEFF Research Database (Denmark)

    Céspedes, Nora; Habel, Catherine; Lopez-Perez, Mary

    2014-01-01

    Protein α-helical coiled coil structures that elicit antibody responses, which block critical functions of medically important microorganisms, represent a means for vaccine development. By using bioinformatics algorithms, a total of 50 antigens with α-helical coiled coil motifs orthologous to Pla...

  2. Screening Donors for Rare Antigen Constellations.

    Science.gov (United States)

    Wagner, Franz F

    2009-01-01

    SCREENING BLOOD DONORS FOR RARE ANTIGEN CONSTELLATIONS HAS BEEN IMPLEMENTED USING SIMPLE PCR METHODS: PCR with enzyme digestion has been used to type donor cohorts for Dombrock antigens, and PCR with sequence-specific priming to identify donors negative for antigens of high frequency. The advantages and disadvantages of the methods as well as their current state is discussed.

  3. Electron loss from multiply protonated lysozyme ions in high energy collisions with molecular oxygen

    DEFF Research Database (Denmark)

    Hvelplund, P; Nielsen, SB; Sørensen, M

    2001-01-01

    We report on the electron loss from multiply protonated lysozyme ions Lys-Hn(n)+ (n = 7 - 17) and the concomitant formation of Lys-Hn(n+1)+. in high-energy collisions with molecular oxygen (laboratory kinetic energy = 50 x n keV). The cross section for electron loss increases with the charge state...... of the precursor from n = 7 to n = 11 and then remains constant when n increases further. The absolute size of the cross section ranges from 100 to 200 A2. The electron loss is modeled as an electron transfer process between lysozyme cations and molecular oxygen....

  4. Mutations in NRXN1 in a family multiply affected with brain disorders

    DEFF Research Database (Denmark)

    Duong, Linh; Klitten, Laura L; Møller, Rikke S

    2012-01-01

    Mutation of the neurexin1-gene, NRXN1, interrupting the expression of neurexin1 has been associated with schizophrenia, autism, and intellectual disability. We have identified a family multiply affected with psychiatric, neurological, and somatic disorders along with an intricate co...... to be deleterious to NRXN1. The deletion was passed on from the patient's mother who was clinically characterized by sub-diagnostic autistic traits in addition to type 1 diabetes mellitus. The point mutation was subsequently found in the patient's brother, suffering from a psychotic disorder, which implies...

  5. The Early Exercise Premium Representation for American Options on Multiply Assets

    Energy Technology Data Exchange (ETDEWEB)

    Klimsiak, Tomasz, E-mail: tomas@mat.umk.pl; Rozkosz, Andrzej, E-mail: rozkosz@mat.umk.pl [Nicolaus Copernicus University, Faculty of Mathematics and Computer Science (Poland)

    2016-02-15

    In the paper we consider the problem of valuation of American options written on dividend-paying assets whose price dynamics follow the classical multidimensional Black and Scholes model. We provide a general early exercise premium representation formula for options with payoff functions which are convex or satisfy mild regularity assumptions. Examples include index options, spread options, call on max options, put on min options, multiply strike options and power-product options. In the proof of the formula we exploit close connections between the optimal stopping problems associated with valuation of American options, obstacle problems and reflected backward stochastic differential equations.

  6. Electron multiplier as a detector for soft x rays from synchrotron and laser plasma sources

    Science.gov (United States)

    Buckley, Christopher J.; Dermody, Geraint; Khaleque, Naz I.; Michette, Alan G.; Pfauntsch, Slawka J.; Turcu, I. C. Edmond; Allott, Ric M.

    1998-11-01

    An electron-tubes-LTD 129EM electron multiplier tube has been modified to act as a detector of soft x-rays. the first dynode was coated with 100 nm of CsI and the assembly was mounted in a small vacuum chamber with 100 nm thick silicon nitride entrance window. Initial tests show the detector is linear up to an input flux of approximately 1MHz on a synchrotron source and has proved effective in providing pulse height discrimination when used on a pulsed laser plasma source.

  7. Analytical theory of frequency-multiplying gyro-traveling-wave-tubes

    International Nuclear Information System (INIS)

    Nusinovich, G.S.; Chen, W.; Granatstein, V.L.

    2001-01-01

    The theory is developed which describes analytically the gain and bandwidth in frequency-multiplying gyro-traveling-wave-tubes. In this theory the input waveguide is considered in the small-signal approximation. Then, in the drift region separating the input and output waveguides, the electron ballistic bunching evolves which causes the appearance in the electron current density of the harmonics of the signal frequency. The excitation of the output waveguide by one of these harmonics is considered in a specified current approximation. This makes the analytical study of a large-signal operation possible. The theory is illustrated by using it to analyze the performance of an existing experimental tube

  8. Indirect mechanisms in electron-impact ionization of multiply charged ions

    International Nuclear Information System (INIS)

    Phaneuf, R.A.; Gregory, D.C.

    1986-09-01

    The important role of indirect-ionization mechanisms in electron-impact ionization of multiply charged ions has been emphasized by some recent experiments conducted with the ORNL-ECR multicharged ion source. Illustrative examples of investigations of the Mg-isoelectronic and Fe-isonuclear sequences are presented and compared with the results of detailed theoretical calculations. New experimental data is also presented concerning the role of resonance effects in the ionization of Li-like O 5+ and Na-like Fe 15+ ions

  9. An aging study of a gas electron multiplier with micro-strip gas chamber readout

    CERN Document Server

    Miyamoto, J

    1999-01-01

    We have performed an aging study of a Gas Electron Multiplier (GEM) readout with a Micro-Strip Gas Chamber (MSGC). The GEM is constructed from Kapton and copper, and the MSGC is constructed from semiconductive glass and gold. When the detector (GEM+MSGC) is operated in an argon-dimethyl ether (DME) gas mixture and irradiated with a 5.4 keV photon beam, about 220 mC/cm of charge can be accumulated without degradation of the detector performance. This corresponds to about 20 years of operation at the LHC.

  10. Single photon timing resolution and detection efficiency of the IRST silicon photo-multipliers

    International Nuclear Information System (INIS)

    Collazuol, G.; Ambrosi, G.; Boscardin, M.; Corsi, F.; Dalla Betta, G.F.; Del Guerra, A.; Dinu, N.; Galimberti, M.; Giulietti, D.; Gizzi, L.A.; Labate, L.; Llosa, G.; Marcatili, S.; Morsani, F.; Piemonte, C.; Pozza, A.; Zaccarelli, L.; Zorzi, N.

    2007-01-01

    Silicon photo-multipliers (SiPM) consist in matrices of tiny, passive quenched avalanche photo-diode cells connected in parallel via integrated resistors and operated in Geiger mode. Novel types of SiPM are being developed at FBK-IRST (Trento, Italy). Despite their classical shallow junction n-on-p structure the devices are unique in their enhanced photo-detection efficiency (PDE) for short-wavelengths and in their low level of dark rate and excess noise factor. After a summary of the extensive SiPM characterization we will focus on the study of PDE and the single photon timing resolution

  11. Identification of an Antigen from Normal Human Tissue That Crossreacts with the Carcinoembryonic Antigen

    Science.gov (United States)

    Kleist, S. Von; Chavanel, G.; Burtin, P.

    1972-01-01

    A glycoprotein present in normal human tissue is characterized that is neither organ- nor tumor-specific (nonspecific crossreacting antigen) and that crossreacts (by the Ouchterlony double-diffusion technique) with the carcinoembryonic antigen. This immunological relationship indicates common determinants on the molecules of both antigens. We demonstrate that the nonspecific crossreacting antigen is not a fragment of the carcinoembryonic antigen molecule. Images PMID:4115954

  12. Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART.

    Directory of Open Access Journals (Sweden)

    Jesse D Deere

    Full Text Available Highly active antiretroviral therapy (HAART can reduce levels of human immunodeficiency virus type 1 (HIV-1 to undetectable levels in infected individuals, but the virus is not eradicated. The mechanisms of viral persistence during HAART are poorly defined, but some reservoirs have been identified, such as latently infected resting memory CD4⁺ T cells. During latency, in addition to blocks at the initiation and elongation steps of viral transcription, there is a block in the export of viral RNA (vRNA, leading to the accumulation of multiply-spliced transcripts in the nucleus. Two of the genes encoded by the multiply-spliced transcripts are Tat and Rev, which are essential early in the viral replication cycle and might indicate the state of infection in a given population of cells. Here, the levels of multiply-spliced transcripts were compared to the levels of gag-containing RNA in tissue samples from RT-SHIV-infected rhesus macaques treated with HAART. Splice site sequence variation was identified during development of a TaqMan PCR assay. Multiply-spliced transcripts were detected in gastrointestinal and lymphatic tissues, but not the thymus. Levels of multiply-spliced transcripts were lower than levels of gag RNA, and both correlated with plasma virus loads. The ratio of multiply-spliced to gag RNA was greatest in the gastrointestinal samples from macaques with plasma virus loads <50 vRNA copies per mL at necropsy. Levels of gag RNA and multiply-spliced mRNA in tissues from RT-SHIV-infected macaques correlate with plasma virus load.

  13. Dispersion, Topological Scattering, and Self-Interference in Multiply Connected Robertson-Walker Cosmologies

    CERN Document Server

    Tomaschitz, R

    1994-01-01

    We investigate scattering effects in open Robertson-Walker cosmologies whose spacelike slices are multiply connected hyperbolic manifolds. We work out an example in which the 3-space is infinite and has the topology of a solid torus. The world-lines in these cosmologies are unstable, and classical probability densities evolving under the horospherical geodesic flow show dispersion, as do the densities of scalar wave packets. The rate of dispersion depends crucially on the expansion factor, and we calculate the time evolution of their widths. We find that the cosmic expansion can confine dispersion: The diameter of the domain of chaoticity in the 3-manifold provides the natural, time-dependent length unit in an infinite, multiply connected universe. In a toroidal 3-space manifold this diameter is just the length of the limit cycle. On this scale we find that the densities take a finite limit width in the late stage of the expansion. In the early stage classical densities and conformally coupled fields approach...

  14. Comparing young and older adults' perceptions of conflicting stereotypes and multiply-categorizable individuals.

    Science.gov (United States)

    Kang, Sonia K; Chasteen, Alison L; Cadieux, Jonathan; Cary, Lindsey A; Syeda, Maisha

    2014-09-01

    Individuals can be simultaneously categorized into multiple social groups (e.g., racial, gender, age), and stereotypes about one social group may conflict with another. Two such conflicting stereotype sets are those associated with older adults (e.g., frail, kind) and with Black people (e.g., violent, hostile). Recent research shows that young adult perceivers evaluate elderly Black men more positively than young Black men, suggesting that components of the elderly stereotype moderate the influence of conflicting Black stereotypes (Kang & Chasteen, 2009). The current research begins to examine whether this pattern of perceiving multiply-categorizable individuals is maintained among older adults or altered, perhaps due to aging-related cognitive and motivational changes. In three studies using different targets and evaluative tasks, both young and older participants showed evidence of an interplay between Black and elderly stereotypes, such that they perceived elderly Black targets more positively than young Black targets. A similar pattern was observed when assessing emotion change (Study 1), making ratings of warmth and power in the past, present, and future (Study 2), and when directly comparing young and old Black and White targets on traits related to warmth and power (Study 3). The absence of age differences suggests that evaluation of multiply-categorizable targets follows comparable underlying patterns of stereotype activation and inhibition in younger and older adults. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  15. Coupled-Multiplier Accelerator Produces High-Power Electron Beams for Industrial Applications

    International Nuclear Information System (INIS)

    Hatridge, M.; McIntyre, P.; Roberson, S.; Sattarov, A.; Thomas, E.; Meitzler, Charles

    2003-01-01

    The coupled multiplier is a new approach to efficient generation of MeV d.c. power for accelerator applications. High voltage is produced by a series of modules, each of which consists of a high-power alternator, step-up transformer, and 3-phase multiplier circuit. The alternators are connected mechanically along a rotating shaft, and connected by insulating flexible couplers. This approach differs from all previous d.c. technologies in that power is delivered to the various stages of the system mechanically, rather than through capacitive or inductive electrical coupling. For this reason the capital cost depends linearly on required voltage and power, rather than quadratically as with conventional technologies. The CM technology enables multiple electron beams to be driven within a common supply and insulating housing. MeV electron beam is extremely effective in decomposing organic contaminants in water. A 1 MeV, 100 kW industrial accelerator using the CM technology has been built and is being installed for treatment of wastewater at a petrochemical plant

  16. A compact system for two-dimensional readout of Gas Electron Multiplier detectors

    International Nuclear Information System (INIS)

    Mindur, B; Dąbrowski, W; Fiutowski, T; Wiącek, P; Zielińska, A

    2013-01-01

    There is a growing interest in the use of Gas Electron Multiplier (GEM) and other micro-pattern gas detectors (MPGD) for two-dimensional (2-D) position sensitive measurements of photons or charged particles. A Gas Electron Multiplier Readout Chip (GEMROC) is an Application Specific Integrated Circuit (ASIC) dedicated for 2-D strip readout of GEM detectors. The ASICs deliver the amplitudes and time coordinates of the signals recorded on two sets of orthogonal strips. Timing information is used for finding coincidences of signals on two spatial coordinates while amplitude information is used to find the center of gravity for the cluster of signals belonging to the same detection event. In this paper we present a Field Programmable Gate Array (FPGA) based compact readout system dedicated for these ASICs. The readout system consists of two synchronized FPGA-ADC boards connected to four front-end boards, each one equipped with two GEMROCs. Both FPGAs are connected to a DAQ PC using separate Gigabit Ethernet links. The DAQ PC is equipped with a dedicated C++ based software, which is responsible for configuration of the FPGAs and ASICs settings, storing all the incoming data as well as for on-line/off-line data processing and visualization. The performance of the system is illustrated by test bench measurements.

  17. Allele intersection analysis: a novel tool for multi locus sequence assignment in multiply infected hosts.

    Directory of Open Access Journals (Sweden)

    Wolfgang Arthofer

    Full Text Available Wolbachia are wide-spread, endogenous α-Proteobacteria of arthropods and filarial nematodes. 15-75% of all insect species are infected with these endosymbionts that alter their host's reproduction to facilitate their spread. In recent years, many insect species infected with multiple Wolbachia strains have been identified. As the endosymbionts are not cultivable outside living cells, strain typing relies on molecular methods. A Multi Locus Sequence Typing (MLST system was established for standardizing Wolbachia strain identification. However, MLST requires hosts to harbour individual and not multiple strains of supergroups without recombination. This study revisits the applicability of the current MLST protocols and introduces Allele Intersection Analysis (AIA as a novel approach. AIA utilizes natural variations in infection patterns and allows correct strain assignment of MLST alleles in multiply infected host species without the need of artificial strain segregation. AIA identifies pairs of multiply infected individuals that share Wolbachia and differ in only one strain. In such pairs, the shared MLST sequences can be used to assign alleles to distinct strains. Furthermore, AIA is a powerful tool to detect recombination events. The underlying principle of AIA may easily be adopted for MLST approaches in other uncultivable bacterial genera that occur as multiple strain infections and the concept may find application in metagenomic high-throughput parallel sequencing projects.

  18. Analysis of microwave amplifier and frequency multiplier tube with a multipactor electron gun

    International Nuclear Information System (INIS)

    Yokoo, Kuniyoshi; Ono, Shoichi; Tai, Dong-Zhe.

    1983-01-01

    The performance analysis was made for a multipactor microwave tube with the aim of realizing a microwave amplifier or a frequency multiplier tube with a multipactor cathode with high efficiency and high power. The possibility for producing the multipactor tube with high efficiency and high power was shown by using effectively the characteristics of the multipactor cathode which emits pulsed electron current with narrow band, synchronizing with high frequency period. As the operating conditions for the multipactor cathode, it was shown that the wide spacing of the cathode was needed for the operation in high operating power, and the narrow spacing was needed for the operation in high efficiency and for reducing power consumption. It was also shown that there were the best values of the high-frequency voltage for the cathode operation. The study by the simulation for the multipactor cathode and for the acceleration zone of electron current was also performed to examine the possible performance for a microwave amplifier and a frequency multiplier tube. For the use of the multipactor cathode with a spacing of 1 mm, the conversion efficiency for d. c. input power was 86, 56 and 31 % for the primary, the secondary and the tertiary harmonic wave amplifications, respectively. (Asami, T.)

  19. Closing of Coster-Kronig transitions in multiply ionised gold atoms

    International Nuclear Information System (INIS)

    Banas, D.; Braziewicz, J.; Czarnota, M.; Fijal, I.; Jaskola, M.; Korman, A.; Kretschmer, W.; Pajek, M.; Semaniak, J.

    2003-01-01

    The paper discusses the effect of closing of L- and M-shell Coster-Kronig (CK) transitions in multiply ionised Au atoms, for which the selected CK transitions become energetically forbidden. This effect plays an important role when the Coster-Kronig energy for single-hole configuration is relatively low, being comparable with a change of the electronic binding energies in multiply ionised atom. We show, by using a simplified model, that for gold the effect of closing of CK transitions occurs for strong L 1 -L 3 M 4,5 transition for the L 1 -subshell as well as the M 3 -M 5 N 6,7 and M 4 -M 5 O 3,4 CK transitions for the M 3 - and M 4 -subshell, respectively. We demonstrate that the discussed effect of closing CK transitions substantially changes the X-ray fluorescence and Coster-Kronig yields and thus has to be considered in interpretation of X-rays excited by heavy ion impact

  20. Evaluation of seismic forces due to anchor movement and inertial effects in multiply supported piping systems

    International Nuclear Information System (INIS)

    Burdisso, R.A.; Singh, M.P.

    1987-01-01

    The results indicate that various ad hoc approaches used for calculating the dynamic and pseudo static responses of a multiply supported secondary system do not provide the correct estimates of the response. The approaches can under- or over-estimate the true response. Also, the contribution of the dynamic, pseudo static responses to the total response is likely to vary with the type of response, member in which the response is calculated, characteristics of the two systems and the input. No generalizations can be made about the relative contribution of these components. Furthermore, the contribution of the correlation between the dynamic and pseudo static response component to the total response can be very significant. It can not be correctly included by the currently used approximate rules for the combination of dynamic and pseudo static responses. In summary, to obtain the correct response for a multiply supported secondary system, one must use proper inputs at the support as well as employ analytically rational approach to calculate the response from the inputs. (orig./HP)

  1. Computational Design Scheme for Wind Turbine Drive-Train Based on Lagrange Multipliers

    Directory of Open Access Journals (Sweden)

    Mohammed Saleh

    2017-01-01

    Full Text Available The design optimization of wind turbines and their subsystems will make them competitive as an ideal alternative for energy. This paper proposed a design procedure for one of these subsystems, which is the Wind Turbine Drive-Train (WTDT. The design of the WTDT is based on the load assumptions and considered as the most significant parameter for increasing the efficiency of energy generation. In industry, these loads are supplemented by expert assumptions and manipulated to design the transmission elements. In contrary, in this work, the multibody system approach is used to estimate the static as well as dynamic loads based on the Lagrange multipliers. Lagrange multipliers are numerical parameters associated with the holonomic and nonholonomic constraints assigned in the drive-train model. The proposed scheme includes computational manipulations of kinematic constraints, mapping the generalized forces into Cartesian respective, and enactment of velocity-based constrains. Based on the dynamic model and the obtained forces, the design process of a planetary stage of WTDT is implemented with trade-off’s optimization in terms of gearing parameters. A wind turbine of 1.4 megawatts is introduced as an evaluation study of the proposed procedure, in which the main advantage is the systematic nature of designing complex systems in motion.

  2. Generating true minima in constrained variational formulations via modified Lagrange multipliers.

    Science.gov (United States)

    Solis, Francisco J; Jadhao, Vikram; Olvera de la Cruz, Monica

    2013-11-01

    Variational principles are important in the investigation of large classes of physical systems. They can be used both as analytical methods as well as starting points for the formulation of powerful computational techniques such as dynamical optimization methods. Systems with charged objects in dielectric media and systems with magnetically active particles are important examples. In these examples and other important cases, the variational principles describing the system are required to obey a number of constraints. These constraints are implemented within the variational formulation by means of Lagrange multipliers. Such constrained variational formulations are in general not unique. For the application of efficient simulation methods, one must find specific formulations that satisfy a number of important conditions. An often required condition is that the functional be positive-definite, in other words, its extrema be actual minima. In this article, we present a general approach to attack the problem of finding, among equivalent variational functionals, those that generate true minima. The method is based on the modification of the Lagrange multiplier which allows us to generate large families of effective variational formulations associated with a single original constrained variational principle. We demonstrate its application to different examples and, in particular, to the important cases of Poisson and Poisson-Boltzmann equations. We show how to obtain variational formulations for these systems with extrema that are always minima.

  3. Linearized Alternating Direction Method of Multipliers for Constrained Nonconvex Regularized Optimization

    Science.gov (United States)

    2016-11-22

    expensive per-iteration computational cost. When A or B is non-diagonal, neither the SCP algorithm nor the GIST algorithm is efficient for solving problem...2. We observe that the propossed algorithm solves both problem (11) and problem (13) efficiently . Compared with ℓ1 regularization, we observe that...Chen, M Hawes, L Mihaylova, J Xiao, and W Liu. Vehicle logo recognition by spatial- sift combined with logistic regression. Proceedings of Fusion 2016

  4. The algorithm design manual

    CERN Document Server

    Skiena, Steven S

    2008-01-01

    Explaining designing algorithms, and analyzing their efficacy and efficiency, this book covers combinatorial algorithms technology, stressing design over analysis. It presents instruction on methods for designing and analyzing computer algorithms. It contains the catalog of algorithmic resources, implementations and a bibliography

  5. The Algorithmic Imaginary

    DEFF Research Database (Denmark)

    Bucher, Taina

    2017-01-01

    of algorithms affect people's use of these platforms, if at all? To help answer these questions, this article examines people's personal stories about the Facebook algorithm through tweets and interviews with 25 ordinary users. To understand the spaces where people and algorithms meet, this article develops....... Examining how algorithms make people feel, then, seems crucial if we want to understand their social power....

  6. Antigenicity of Dermatophilus congolensis hemolysin.

    Science.gov (United States)

    Skalka, B; Pospísil, L

    1993-05-01

    The separated cell-free form of hemolytic exosubstance was obtained from five strains of Dermatophilus congolensis. Three strains produced exosubstance with high activity, two strains produced exosubstance with lower intensity of activity. The separated forms exhibited the same hemolytic interactions as the native forms produced by growing strains, namely the antagonism with staphylococcal beta hemolysin and the synergism with staphylococcal delta hemolysin, streptococcal CAMP factor and rhodococcal equi factor. Rabbit sera obtained after intravenous or intraperitoneal application of the separated forms contained precipitation and neutralization antibodies. Cross tests of precipitation and neutralization proved antigen identity of hemolysins of different D. congolensis, strains which makes the serodiagnostics of this species possible.

  7. Algorithmically specialized parallel computers

    CERN Document Server

    Snyder, Lawrence; Gannon, Dennis B

    1985-01-01

    Algorithmically Specialized Parallel Computers focuses on the concept and characteristics of an algorithmically specialized computer.This book discusses the algorithmically specialized computers, algorithmic specialization using VLSI, and innovative architectures. The architectures and algorithms for digital signal, speech, and image processing and specialized architectures for numerical computations are also elaborated. Other topics include the model for analyzing generalized inter-processor, pipelined architecture for search tree maintenance, and specialized computer organization for raster

  8. Enrichment and separation of mono- and multiply phosphorylated peptides using sequential elution from IMAC prior to mass spectrometric analysis

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Larsen, Martin R

    2009-01-01

    Phospho-proteomics relies on methods for efficient purification and sequencing of phosphopeptides from highly complex biological systems using low amounts of starting material. Current methods for phosphopeptide enrichment, e.g., immobilized metal affinity chromatography and titanium dioxide...... multiply phosphorylated peptides using sequential elution from immobilized metal affinity chromatography is described. The two separate phosphopeptide fractions are subsequently analyzed by mass spectrometric methods optimized for mono-phosphorylated and multiply phosphorylated peptides, respectively...... chromatography, provide varying degrees of selectivity and specificity for phosphopeptide enrichment. Furthermore, the number of multiply phosphorylated peptides that are identified in most published studies is rather low. Here the protocol for a new strategy that separates mono-phosphorylated pep-tides from...

  9. In-situ and elementally resolved determination of the thickness uniformity of multi-ply films by confocal micro XRF.

    Science.gov (United States)

    Peng, Song; Liu, Zhiguo; Sun, Tianxi; Wang, Guangfu; Ma, Yongzhong; Ding, Xunliang

    2014-08-01

    Confocal micro X-ray fluorescence (CM-XRF) with quasi-monochromatic excitation based on polycapillary X-ray optics was used to measure the thickness of multi-ply films. The relative errors of measuring an Fe film with a thickness of 16.3 μm and a Cu film with a thickness of 24.5 μm were 7.3% and 0.4%, respectively. The non-destructive and in-situ measurement of the thickness and uniformity of multi-ply films of Cu, Fe and Ni on a silicon surface was performed. CM-XRF was convenient in in-situ and elementally resolved analysis of the thickness of multi-ply films without a cumbersome theoretical correction model. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. DESIGN AND ANALYSIS OF LOW POWER MULTIPLY AND ACCUMULATE UNIT USING PIXEL PROPERTIES REUSABILITY TECHNIQUE FOR IMAGE PROCESSING SYSTEMS

    Directory of Open Access Journals (Sweden)

    M. Madheswaran

    2012-08-01

    Full Text Available The design of low power high performance Multiply and Accumulate (MAC unit is presented in this paper. The power analysis for MAC unit is carried out for image filtering application exploiting insignificant bits in pixel values. The developed technique is found to reduce dynamic power consumption by analyzing the bit patterns in the input data which reduces the switching activities. The power consumption of the developed multiplier is compared with existing multiplier techniques and found that is performs better. It is observed from the simulation using SYNOPSIS EDA tool that the proposed pixel properties reusability technique saves power up to 88% with small area over head when used in MAC unit.

  11. Liquid Hole-Multipliers: A potential concept for large single-phase noble-liquid TPCs of rare events

    Science.gov (United States)

    Breskin, Amos

    2013-10-01

    A novel concept is proposed for large-volume single-phase noble-liquid TPC detectors for rare events. Both radiation-induced scintillation-light and ionization-charge are detected by Liquid Hole-Multipliers (LHM), immersed in the noble liquid. The latter may consist of cascaded Gas Electron Multipliers (GEM), Thick Gas Electron Multiplier (THGEM) electrodes or others, coated with CsI UV-photocathodes. Electrons, photo-induced on CsI by primary scintillation in the noble liquid, and event-correlated drifting ionization electrons are amplified in the cascaded elements primarily through electroluminescence, and possibly through additional moderate avalanche, occurring within the holes. The resulting charge-signals or light-pulses are recorded on anode pads or with photosensors - e.g. gaseous photomultipliers (GPM), respectively. Potential affordable solutions are proposed for multi-ton dark-matter detectors; open questions are formulated for validating this dream.

  12. Liquid Hole-Multipliers: A potential concept for large single-phase noble-liquid TPCs of rare events

    International Nuclear Information System (INIS)

    Breskin, Amos

    2013-01-01

    A novel concept is proposed for large-volume single-phase noble-liquid TPC detectors for rare events. Both radiation-induced scintillation-light and ionization-charge are detected by Liquid Hole-Multipliers (LHM), immersed in the noble liquid. The latter may consist of cascaded Gas Electron Multipliers (GEM), Thick Gas Electron Multiplier (THGEM) electrodes or others, coated with CsI UV-photocathodes. Electrons, photo-induced on CsI by primary scintillation in the noble liquid, and event-correlated drifting ionization electrons are amplified in the cascaded elements primarily through electroluminescence, and possibly through additional moderate avalanche, occurring within the holes. The resulting charge-signals or light-pulses are recorded on anode pads or with photosensors – e.g. gaseous photomultipliers (GPM), respectively. Potential affordable solutions are proposed for multi-ton dark-matter detectors; open questions are formulated for validating this dream

  13. Experiment study on the thick GEM-like multiplier for X-ray photoelectrons energy deposition gaining

    International Nuclear Information System (INIS)

    Zhu Pengfei; Ye Yan; Long Yan; Cao Ningxiang; Jia Xing; Li Jianfeng

    2009-01-01

    The GEM is a novel detector with high gain,high time and location resolution. Imitating the structure of the GEM, a thick GEM-like multiplier which has the similar function with that of the GEM is designed and manufactured. The characteristics of the thick GEM-like multiplier increasing electron energy deposition in absorbing medium has been experimentally studied. The results indicate that the energy deposition gain of x-ray photoelectron in medium is apparent, and the maximum energy deposition can increase by more than 40%. Some suggestions of further increasing the energy deposition are given, and the future application of the way of increasing the x-ray photoelectron energy deposition by the thick GEM-like multiplier in hard x-ray imaging is prospected. (authors)

  14. Multiplier of employment and wages: A comparative study for southern region and the rest of Brazil in 1999 and 2004

    Directory of Open Access Journals (Sweden)

    Angel dos Santos Fachinelli

    2014-06-01

    Full Text Available The objective of this study is to analyze the multiplier effect of jobs and income for the formal and informal categories, in an inter-regional input-output system. Therefore, it was used the array in the Southern Region and the Rest of Brazil, estimated for the years 1999 and 2004 organized in 23 sectors, with microdata from the National Household Sample Survey (PNAD in the same years. Consider one, the individuals’ characterization according to educational level, age, income, gender and employment category (formal and informal. The main results include a decrease of the contribution from the macros sectors of Agricultural and Services in the regions. The State of Paraná, Santa Catarina and the Rest of Brazil decreased multipliers wages in formal and informal categories for most sectors, which was not observed in Rio Grande do Sul. The largest employment multipliers for both formal and informal categories were to sectors linked to Industry.

  15. Isolation and partial characterization of an immunogenic antigen of Giardia lamblia.

    Science.gov (United States)

    Quintero, Jael; Valdez, Alejandra; Samaniego, Brenda; Lopez-Romero, Gloria; Astiazaran-Garcia, Humberto; Rascon, Lucila; Breci, Linda; Garibay-Escobar, Adriana; Robles-Zepeda, Ramón; Velazquez, Carlos

    2017-06-01

    Humoral and cellular immune responses play an important role during Giardia lamblia infection. Several Giardia proteins have been identified as immunogenic antigens based on their elicited humoral immune response. Poorly is known about Giardia antigens that stimulate a cellular immune response. The main purpose of this study was to isolate and partial characterize an immunogenic antigen (5G8) of G. lamblia. The 5G8 protein was isolated from G. lamblia trophozoite lysates by affinity chromatography using moAb 5G8-coupled CNBr-Sepharose. The isolated protein was analysed by electrospray tandem mass spectrometry (ESI-MS/MS), and by diverse bioinformatics tools (GiardiaDB, BLASTn, BLASTp and ExPASy). Additionally, several biochemical and immunological characteristics of the isolated protein were analysed. By ESI-MS/MS the amino acidic 5G8 sequence was deduced. The 5G8 antigen belongs to the VSP family proteins of G. lamblia. This protein is composed by one polypeptide chain (±71kDa). Using the algorithm SYFPHEITI, we identified candidate CD4 + T-cell epitopes from the 5G8 antigen, which can elicit cell-mediated immune responses. In this study, we have identified a G. lamblia protein that induces a strong immune response in infected mice. The biochemical and immunological characterization of the immunogenic 5G8 antigen may contribute to the rational design of a Giardia vaccine. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  16. Isolation of Fasciola hepatica tegument antigens.

    OpenAIRE

    Hillyer, G V

    1980-01-01

    Fasciola hepatica tegument antigens were isolated from intact worms in the cold by using Nonidet P-40. Proof of the tegumental nature of the antigens was shown by the peroxidase-antiperoxidase immunocytochemical technique at the light microscope level. The potential of F. hepatica tegument antigens for the immunodiagnosis of rabbit and human fascioliasis was shown by Ouchterlony immunodiffusion, although cross-reactivity was evident in one of six serum samples from patients infected with Schi...

  17. Correlation transfer and diffusion of ultrasound-modulated multiply scattered light.

    Science.gov (United States)

    Sakadzić, Sava; Wang, Lihong V

    2006-04-28

    We develop a temporal correlation transfer equation (CTE) and a temporal correlation diffusion equation (CDE) for ultrasound-modulated multiply scattered light. These equations can be applied to an optically scattering medium with embedded optically scattering and absorbing objects to calculate the power spectrum of light modulated by a nonuniform ultrasound field. We present an analytical solution based on the CDE and Monte Carlo simulation results for light modulated by a cylinder of ultrasound in an optically scattering slab. We further validate with experimental measurements the numerical calculations for an actual ultrasound field. The CTE and CDE are valid for moderate ultrasound pressures and on a length scale comparable with the optical transport mean-free path. These equations should be applicable to a wide spectrum of conditions for ultrasound-modulated optical tomography of soft biological tissues.

  18. The Strip Silicon Photo-Multiplier: An innovation for enhanced time and position measurement

    Energy Technology Data Exchange (ETDEWEB)

    Doroud, K., E-mail: Katayoun.Doroud@cern.ch [CERN, Geneva (Switzerland); Williams, M.C.S. [CERN, Geneva (Switzerland); INFN, Bologna (Italy); Yamamoto, K. [Solid State Division, Hamamatsu Photonics K.K., Hamamatsu (Japan)

    2017-05-01

    There is considerable R&D concerning precise time measurement from a variety of detectors, and in particular for the Silicon PhotoMultiplier (SiPM). In this paper we discuss a new geometry for the SiPM in the form of a strip. A strip can be read out at both end, with each end coupled to an individual TDC (time to digital converter). The time difference is related to the position of the firing SPAD along the length of the strip, while the average of the two times gives the time of the hit. Results from the testing of the first prototype Strip SiPMs are presented in this paper.

  19. Parallel ionization multiplier: A gaseous detector dedicated to the tracking of minimum ionization particles

    Science.gov (United States)

    Beucher, J.; Girault, S.; Leray, P.; Lupone, S.; Luquin, L.; Metivier, V.; Morteau, E.; Samarati, J.; Servagent, N.; Thers, D.

    2007-04-01

    We report gain and discharge rate measurements with micropattern gaseous detectors using micromeshes. Some geometrical configurations of parallel ionization multiplier (PIM) and MICROMEGAS, operated with Ne+10% CO 2 gas mixture, are considered. Tests have been performed on the T9 proton-pion beam facility at CERN (PS). For MICROMEGAS configurations, the discharge rate, when greater than 3×10 -7, is correlated to the thickness of the amplification gap. On the other side, for lower probabilities, the amplification gap thickness does not seem to be discriminatory, suggesting that some particularly interesting physic interactions are observed. With the PIM structure operated at a gain of 5000, the best configuration allows to achieve a rate of discharges lower than 10 -9. Some elements are now understood to reduce this discharge rate with only two amplification stages, such as using ions with greater velocities or thinner amplification gap. R&D activities are under progress in order to complete this study.

  20. Quantum efficiency measurements of windowless electro multipliers to heavy high energy particles

    International Nuclear Information System (INIS)

    Cho, Z.H.; Singh, M.; Mohabbatizadeh, A.; Sackerlotzky, O.H.; Amore, L.

    1974-01-01

    Measurements of quantum efficiency to heavy charged particles, in particular to the proton, in the range of 5 to 2 MeV were made with windowless electron multipliers on cathodes of beryllium oxide and aluminum oxide. The effects of oxide thickness on quantum efficiency were determined and some qualitative explanations have been made based on the simple ionization process and escape probability of produced electrons. Using a Van de Graaff accelerator at beam currents of .1 nA to .5 nA, precisions of measurement of better than 10 percent were obtainable with six different cathodes: three different thicknesses of BeO and three of Al 2 O 3 respectively

  1. Platinum(IV) prodrugs multiply targeting genomic DNA, histone deacetylases and PARP-1.

    Science.gov (United States)

    Xu, Zichen; Hu, Weiwei; Wang, Zhimei; Gou, Shaohua

    2017-12-01

    Several Pt(IV) prodrugs containing SAA, a histone deacetylases inhibitor, were designed and prepared for multiply targeting genomic DNA, histone deacetylases and PARP-1. The resulting Pt(IV) prodrug had significantly strong antiproliferative activity against the tested cancer cell lines, especially SAA1, derived from the conjugation of cisplatin and SAA, had potent ability to overcome cisplatin resistance. Under the combined action of DNA platination and inhibition of HDACs and PARP-1 activity, the cytotoxic activity of SAA1 was 174-fold higher than cisplatin against cisplatin-resistant SGC7901/CDDP cancer cells. The mechanism of action of SAA1 was preliminarily investigated, in which cellular uptake, cell apoptosis and cell cycle arrest as well as western blot analysis were made by treating SAA1 with SGC7901/CDDP cells. Besides, HDACs inhibition activity and PARP-1 enzyme inhibition of SAA1 were also studied. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  2. The gain in Thick GEM multipliers and its time-evolution

    CERN Document Server

    Alexeev, M; Bradamante, F; Bressan, A; Buechele, M; Chiosso, M; Ciliberti, P; Dalla Torre, S; Dasgupta, S; Denisov, O; Duic, V; Finger, M; Finger Jr, M; Fischer, H; Gobbo, B; Gregori, M; Herrmann, F; Koenigsmann, K; Levorato, S; Maggiora, A; Makke, N; Martin, A; Menon, G; Novakova, K; Novy, J; Panzieri, D; Pereira, F A; Santos, C A; Sbrizzai, G; Schiavon, P; Schopferer, S; Slunecka, M; Sozzi, F; Steiger, L; Sulc, M; Takekawa, S; Tessarotto, F; Veloso, J F C A

    2016-01-01

    In the context of a project to upgrade the gas photon detectors of COMPASS RICH-1, we have performed an R&D programme aimed to develop photon detectors based on multi-layer arrangements of thick GEM electron multipliers coupled to a CsI photoconverter. For this purpose, thick GEMs have been characterised in detail including the gain performance, its dependance on the geometrical parameters and its time-evolution, a feature exhibited by the gas detectors with open insulator surfaces. The variation due to this evolution drammatically depends on the parameters themselves. In the present article we summarise the outcomes of the studies dedicated to the thick GEM gain and its evolution versus time. We also include a qualitative model which accounts for the peculiar details of the observed thick GEM gain time-evolution.

  3. Gaseous flat-panel detector with glass gas electron multiplier coupled with micro-photodiode array

    Science.gov (United States)

    Mitsuya, Yuki; Miyoshi, Hiroaki; Fujiwara, Takeshi; Uesaka, Mitsuru; Takahashi, Hiroyuki

    2017-11-01

    In this study, we propose and demonstrate a novel imaging system, a gaseous flat-panel detector (FPD). The gaseous FPD consists of a glass gas electron multiplier (G-GEM) with a scintillation gas, which is optically coupled with photodiode panel fabricated with liquid crystal display technology. The G-GEM is ideal as a low energy deposition radiation detector because of its single stage high gas-gain and hence, its high photon yield. We obtained a preliminary X-ray image with the system by using a Ne/CF4 90/10 gas mixture. The typical position resolution was 0.93 mm in FWHM, which was obtained from the fitting of edge profiles

  4. Construction and performance of a micro-pattern stereo detector with two gas electron multipliers

    Energy Technology Data Exchange (ETDEWEB)

    Barvich, T.; Bluem, P.; Erdmann, M. E-mail: Martin.Erdmann@cern.ch; Fahrer, M.; Kaercher, K.; Kuehn, F.; Moermann, D.; Mueller, Th.; Neuberger, D.; Roederer, F.; Simonis, H.J.; Skiba, A.; Thuemmel, W.H.; Weiler, Th.; Weseler, S

    2002-06-11

    The construction of a micro-pattern gas detector of dimensions 40x10 cm{sup 2} is described. Two gas electron multiplier foils (GEM) provide the internal amplification stages. A two-layer readout structure was used, manufactured using the same technology as the GEM foils. The strips of each layer cross at an effective crossing angle of 6.7 deg. and have a 406 {mu}m pitch. The performance of the detector has been evaluated in a muon beam at CERN using a silicon telescope as reference system. The position resolutions of two orthogonal coordinates are measured to be 50 {mu}m and 1 mm, respectively. The muon detection efficiency for two-dimensional space points reaches 96%.

  5. Performance test of a micro-pattern stereo detector with two gas electron multipliers

    Energy Technology Data Exchange (ETDEWEB)

    Barvich, T.; Bluem, P.; Erdmann, M. E-mail: martin.erdmann@cern.ch; Fahrer, M.; Kaercher, K.; Kuehn, F.; Moermann, D.; Mueller, Th.; Neuberger, D.; Roederer, F.; Simonis, H.J.; Skiba, A.; Thuemmel, W.H.; Weiler, Th.; Weseler, S

    2002-02-01

    We report on the performance of a large micro-pattern detector with two gas electron multiplier foils and a two-layer readout structure at ground potential. The two readout layers each have a 406 {mu}m pitch and cross at an effective angle of 6.7 deg. . This structure allows for two orthogonal coordinates to be determined. Using a muon beam at CERN together with a silicon tracking system, the position resolutions of the two coordinates are measured to be 50 {mu}m and 1 mm respectively (1 standard deviation). The muon detection efficiency for the two-dimensional space points reaches 96%. The detector was found to be well operational over a wide range in the settings of the different electrical fields.

  6. Development of a New Multiplying Assembly for Research, Validation, Evaluation, and Learning

    Energy Technology Data Exchange (ETDEWEB)

    David L. Chichester

    2012-10-01

    A new multiplying test assembly is under development at Idaho National Laboratory (INL) to support research, validation, evaluation, and learning. The item is comprised of two stacked highly-enriched uranium (HEU) cylinders each 11.4 cm in diameter and having a combined height of 8.4 cm. The combined mass is 14.4 kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >2.5 (keff = 0.62). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising its multiplication level to approximately 8. This paper will describe the MCNP calculations performed to assess the assembly's multiplication level under different conditions and describe the resource available at INL to support visiting researchers in their use of the material. We will also describe some preliminary calculations and test activities using the assembly to study neutron multiplicity.

  7. High- and low-pressure operation of the gas electron multiplier

    International Nuclear Information System (INIS)

    Bondar, A.; Buzulutskov, A.; Shekhtman, L.; Sauli, F.

    1998-01-01

    We have studied the operation of the gas electron multiplier (GEM) in gas mixtures Xe-CO 2 , Ar-CO 2 and CH 4 at different pressures varying from 0.1 to 5 atm. In Ar- and Xe-based mixtures, the maximum GEM gain considerably decreases with pressure, from a few hundreds at 1 atm to below 10 at 5 atm. Combined gain of GEM and the micro-strip gas chamber (MSGC) can exceed values of 10000 at 1 atm and 100 at 5 atm. High GEM gains, of above 1000, were obtained in CH 4 at low pressures. We have observed the effect of the avalanche confinement in GEM micro-holes, resulting in violation of the pressure scaling and in the possibility of GEM operation in pure noble gases. (author)

  8. Performance test of a micro-pattern stereo detector with two gas electron multipliers

    International Nuclear Information System (INIS)

    Barvich, T.; Bluem, P.; Erdmann, M.; Fahrer, M.; Kaercher, K.; Kuehn, F.; Moermann, D.; Mueller, Th.; Neuberger, D.; Roederer, F.; Simonis, H.J.; Skiba, A.; Thuemmel, W.H.; Weiler, Th.; Weseler, S.

    2002-01-01

    We report on the performance of a large micro-pattern detector with two gas electron multiplier foils and a two-layer readout structure at ground potential. The two readout layers each have a 406 μm pitch and cross at an effective angle of 6.7 deg. . This structure allows for two orthogonal coordinates to be determined. Using a muon beam at CERN together with a silicon tracking system, the position resolutions of the two coordinates are measured to be 50 μm and 1 mm respectively (1 standard deviation). The muon detection efficiency for the two-dimensional space points reaches 96%. The detector was found to be well operational over a wide range in the settings of the different electrical fields

  9. Gas electron multiplier (GEM) operation with tissue-equivalent gases at various pressures

    International Nuclear Information System (INIS)

    Farahmand, M.; Bos, A.J.J.; Eijk, C.W.E. van

    2003-01-01

    We have studied the operation of two different Gas Electron Multiplier (GEM) structures in both methane and propane based Tissue-Equivalent (TE) gases at different pressures varying from 0.1 to 1 atm. This work was motivated to explore the possibility of using a GEM for a new type of Tissue Equivalent Proportional Counter. In methane based TE gas, a maximum safe GEM gain of 1.5x10 3 has been reached while in propane based TE gas this is 6x10 3 . These maxima have been reached at different gas pressures depending on GEM structure and TE gas. Furthermore, we observed a decrease of the GEM gain in time before it becomes stable. Charge up/polarisation effects can explain this

  10. Western Australian marsupials are multiply infected with genetically diverse strains of Toxoplasma gondii.

    Directory of Open Access Journals (Sweden)

    Shuting Pan

    Full Text Available Five different organs from 16 asymptomatic free-ranging marsupial macropods (Macropus rufus, M. fuliginosus, and M. robustus from inland Western Australia were tested for infection with Toxoplasma gondii by multi-locus PCR-DNA sequencing. All macropods were infected with T. gondii, and 13 had parasite DNA in at least 2 organs. In total, 45 distinct T. gondii genotypes were detected. Fourteen of the 16 macropods were multiply infected with genetically distinct T. gondii genotypes that often partitioned between different organs. The presence of multiple T. gondii infections in macropods suggests that native mammals have the potential to promote regular cycles of sexual reproduction in the definitive felid host in this environment.

  11. iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova.

    Science.gov (United States)

    Goobar, A; Amanullah, R; Kulkarni, S R; Nugent, P E; Johansson, J; Steidel, C; Law, D; Mörtsell, E; Quimby, R; Blagorodnova, N; Brandeker, A; Cao, Y; Cooray, A; Ferretti, R; Fremling, C; Hangard, L; Kasliwal, M; Kupfer, T; Lunnan, R; Masci, F; Miller, A A; Nayyeri, H; Neill, J D; Ofek, E O; Papadogiannakis, S; Petrushevska, T; Ravi, V; Sollerman, J; Sullivan, M; Taddia, F; Walters, R; Wilson, D; Yan, L; Yaron, O

    2017-04-21

    We report the discovery of a multiply imaged, gravitationally lensed type Ia supernova, iPTF16geu (SN 2016geu), at redshift z = 0.409. This phenomenon was identified because the light from the stellar explosion was magnified more than 50 times by the curvature of space around matter in an intervening galaxy. We used high-spatial-resolution observations to resolve four images of the lensed supernova, approximately 0.3 arc seconds from the center of the foreground galaxy. The observations probe a physical scale of ~1 kiloparsec, smaller than is typical in other studies of extragalactic gravitational lensing. The large magnification and symmetric image configuration imply close alignment between the lines of sight to the supernova and to the lens. The relative magnifications of the four images provide evidence for substructures in the lensing galaxy. Copyright © 2017, American Association for the Advancement of Science.

  12. Characterization of photo-multiplier tube as ex-vessel radiation detector in tokamak

    Science.gov (United States)

    Jo, Jungmin; Cheon, MunSeong; Kim, Junghee; An, YoungHwa; Park, Seungil; Chung, Kyoung-Jae; Hwang, Y. S.

    2017-09-01

    Feasibility of using conventional photo-multiplier tubes (PMTs) without a scintillator as an ex-vessel radiation detector in a tokamak environment is studied. Basic irradiation tests using standard gamma ray sources and a d-d neutron generator showed that the PMT is responding both to gamma photons and neutrons, possibly due to the direct generation of secondary electrons inside the PMT by the impingement of high energy photons. Because of the selective sensitivity of the PMT to hard x-ray and neutrons in ohmic and neutral beam injected plasmas, respectively, it is shown that the PMT with certain configuration can be utilized either to monitor the fluctuation in the fusion neutron generation rate or to study the behavior of runaway electrons in tokamaks.

  13. Kelvin Viscoelasticity and Lagrange Multipliers Applied to the Simulation of Nonlinear Structural Vibration Control

    Directory of Open Access Journals (Sweden)

    Raphael Henrique Madeira

    Full Text Available Abstract This study proposes a new pure numerical way to model mass / spring / damper devices to control the vibration of truss structures developing large displacements. It avoids the solution of local differential equations present in traditional convolution approaches to solve viscoelasticity. The structure is modeled by the geometrically exact Finite Element Method based on positions. The introduction of the device's mass is made by means of Lagrange multipliers that imposes its movement along the straight line of a finite element. A pure numerical Kelvin/Voigt like rheological model capable of nonlinear large deformations is originally proposed here. It is numerically solved along time to accomplish the damping parameters of the device. Examples are solved to validate the formulation and to show the practical possibilities of the proposed technique

  14. Liquid-drop model for fragmentation of multiply charged mercury clusters.

    Science.gov (United States)

    Nakamura, Masato; Tarento, René-Jean

    2018-02-28

    The fragmentation of doubly and triply charged mercury clusters is theoretically studied to analyze an experiment performed by Katakuse's group at Osaka University [T. Satoh et al., J. Mass Spectrom. Soc. Jpn. 51, 391 (2003)]. The fission barrier is calculated using a liquid-drop model proposed by Echt et al. In the decay of doubly charged clusters, the barrier height is found to take the minimum value for nearly symmetric fission. On the other hand, in the decay of triply charged clusters, the barrier is the lowest for strongly asymmetric fission. These results well explain the product size distribution observed in the experiment. The appearance size for multiply charged clusters measured in the experiment is found to be the size where the fission barrier is equal to the monomer evaporation energy. These findings provide evidence that small mercury clusters behave like van der Waals clusters in the process of fragmentation.

  15. Analysis of voltage multiplier circuit simulation for rain energy harvesting using circular piezoelectric

    Science.gov (United States)

    Abidin, Nik Ahmad Kamil Zainal; Nayan, Norkharziana Mohd; Azizan, Muhammad Mokhzaini; Ali, Azuwa

    2018-02-01

    Piezoelectric energy harvester extracts energy based on the magnitude of vibration source and the resonant frequency. In order to get the maximum voltage output, the piezoelectric must receive higher vibration to obtain the frequency near at its resonant frequency. However, it is difficult to obtain the high and stable of vibration from the surrounding to impact on the piezoelectric. Therefore, in order to fix this problem, the voltage multiplier circuit is designed to improve the magnitude of the output gained from the piezoelectric. In order to analyze the potential output produce from rain energy, this paper present three types of circuit for investigation which are voltage doubler, Cockcroft Walton Cascade Voltage Doubler (CWCVD) and Karthaus Fischer Cascade Voltage Doubler (KFCVD). The output voltage and current were investigated to obtain the optimum output based on the result of the simulation. The circuit then can be applied for rain energy harvesting.

  16. Generation of symmetry coordinates for crystals using multiplier representations of the space groups

    DEFF Research Database (Denmark)

    Hansen, Flemming Yssing

    1978-01-01

    Symmetry coordinates play an important role in the normal-mode calculations of crystals. It is therefore of great importance to have a general method, which may be applied for any crystal at any wave vector, to generate these. The multiplier representations of the space groups as given by Kovalev...... and the projection-operator technique provide a basis for such a method. The method is illustrated for the nonsymmorphic D36 space group, and the theoretical background for the representations of space groups in general is reviewed and illustrated on the example above. It is desirable to perform the projection...... of symmetry coordinates in such a way that they may be used for as many wave vectors as possible. We discuss how to achieve this goal. The detailed illustrations should make it simple to apply the theory in any other case....

  17. A Combined Coefficient Segmentation and Block Processing Algorithm for Low Power Implementation of FIR Digital Filters

    Directory of Open Access Journals (Sweden)

    A. T. Erdogan

    2002-01-01

    Full Text Available A combined coefficient segmentation and block processing algorithm for low power implementation of FIR digital filters is described in this paper. The algorithm processes data and coefficients in blocks of fixed sizes. During the manipulation of each block, coefficients are segmented into two primitive components. The accumulative effect of processing a sequence of blocks and segmentation results in up to 80% reduction in power consumption in the multiplier circuit compared to conventional filtering. The paper describes the implementation of the algorithm, its constituent components, and the power evaluation environment developed. Simulations are performed using eight practical digital filter examples with various filter orders and data/coefficient wordlengths. In addition, the algorithm is compared with conventional filtering implementations and those using block processing and coefficient segmentation algorithms alone.

  18. The Financial Unlinkage of the Mexican Economy: A Social Accounting Matrix Multiplier Approach for a One-Sector Economy

    Directory of Open Access Journals (Sweden)

    Andrés Blancas

    2003-11-01

    Full Text Available This paper addresses the financial unlinkage in Mexico through an accounting multiplier analysis derived from a SAM for a one-sector economy. Such an analysis provides a useful tool to quantify processes of structural financial change in terms of "stylized parameters". We identify and measure the financial unlinkage with financial backward and forward linkage indices derived from the accounting multipliers. The results can also help to the quality of policy decisions by identifying key and weak financial institutions and by giving a better understanding of how an impact of an initial financial injection travels within a structure.

  19. An overview of current developments in position-sensitive hybrid photon detectors and photo-multiplier tubes

    CERN Document Server

    Gys, Thierry

    1999-01-01

    Current developments in position-sensitive hybrid photon detectors and photo-multiplier tubes have stimulated increased interest from a variety of fields such as astronomy, biomedical imaging and high- energy physics. These devices are sensitive to single photons over a photon energy spectrum defined by the transmission of the optical entrance window and the photo-cathode type. Their spatial resolution ranges from a few millimeters for pad hybrid photon detectors and multi-anode photo-multiplier tubes down to a few tens of microns for pixel hybrid photon detectors and electron-bombarded charge-coupled devices. Basic technological and design aspects are assessed in this paper. (21 refs).

  20. Investigations of effect of target thickness and detector collimation on 662 keV multiply backscattered gamma photons

    International Nuclear Information System (INIS)

    Sabharwal, Arvind D.; Sandhu, B.S.; Singh, Bhajan

    2009-01-01

    The present studies aimed to investigate the effects of detector collimation and target thickness on multiply backscattered gamma photons. The numbers of multiply backscattered events, having energy the same as in singly scattered distribution, are found to be increasing with target thickness, and saturate for a particular thickness known as saturation thickness. The saturation thickness is not altered by the variation in the collimator opening. The number and energy albedos, characterizing the reflection probability of a material, are also evaluated. Monte Carlo calculations support the present experimental work.

  1. Effect of irradiation angle on the efficiency of formation of multiply charged ions in a laser-produced plasma

    International Nuclear Information System (INIS)

    Bedilov, M R; Beisembaeva, Kh B; Tsoi, T G; Satybaldiev, T B; Sabitov, M S

    2000-01-01

    Mass spectrometry is used to investigate the emission behaviour and the characteristics of multiply charged ions in a plasma produced at small angles of incidence of laser radiation (α∼20 0 ) and also at grazing incidence (α∼85 0 ). It is found that upon grazing incidence of the laser radiation onto a target, the efficiency of production of multiply charged ions is reduced compared to that for α∼20 0 . However, this geometry of laser irradiation of solids can be used for the elemental analysis of surface layers of a sample. (interaction of laser radiation with matter. laser plasma)

  2. Digital predistortion of 75–110 GHz W-band frequency multiplier for fiber wireless short range access systems

    DEFF Research Database (Denmark)

    Zhao, Ying; Deng, Lei; Pang, Xiaodan

    2011-01-01

    We present a W-band fiber-wireless transmission system based on a nonlinear frequency multiplier for high-speed wireless short range access applications. By implementing a baseband digital signal predistortion scheme, intensive nonlinear distortions induced in a sextuple frequency multiplier can...... be effectively pre-compensated. Without using costly W-band components, a transmission system with 26km fiber and 4m wireless transmission operating at 99.6GHz is experimentally validated. Adjacent-channel power ratio (ACPR) improvements for IQ-modulated vector signals are guaranteed and transmission...

  3. Digital Predistortion of 75-110GHzW-Band Frequency Multiplier for Fiber Wireless Short Range Access Systems

    DEFF Research Database (Denmark)

    Zhao, Ying; Pang, Xiaodan; Deng, Lei

    2011-01-01

    We present a digital predistortion technique to effectively compensate high nonlinearity of a sextuple multiplier operating at 99.6GHz. An 18.9dB adjacent-channel power ratio (ACPR) improvement is guaranteed and a W-band fiber-wireless system is experimentally investigated.......We present a digital predistortion technique to effectively compensate high nonlinearity of a sextuple multiplier operating at 99.6GHz. An 18.9dB adjacent-channel power ratio (ACPR) improvement is guaranteed and a W-band fiber-wireless system is experimentally investigated....

  4. The South African wildlife ranching sector: A Social Accounting Matrix Leontief multiplier analysis

    Directory of Open Access Journals (Sweden)

    Philippus C. Cloete

    2014-10-01

    Research purpose: The purpose of this article is to put into context the relative economic contribution of the wildlife ranching sector, as opposed to other land-use options in South Africa. Motivation for the study: Growth in the wildlife ranching sector at the cost of other traditional farming practices resulted in disagreements amongst various role players about the impact thereof on the national economy. The controversy can most probably be explained by different beliefs, coupled with the lack of a proper understanding and quantification of the wildlife ranching sector’s contribution toward the economy. Research methodology: The study employed a Social Accounting Matrix-based Leontief multiplier analysis for South Africa. Main findings: Results from the multiplier analysis revealed that developments within the wildlife ranching sector are likely to make a relatively more superior contribution towards the economy, especially when compared to similar land-use options such as extensive livestock production. Practical/managerial implications: It has been acknowledged by both academia and private sector that a major need exists for more research on the South African wildlife ranching industry, specifically looking at issues such as the industries, economic and social contributions, potentials and constraints. The research, therefore, contributes toward the depth of economic information and research regarding the South African wildlife sector. Contribution/value added: The research provides valuable information in dealing with the ‘popular belief’, especially amongst some of South Africa’s decision makers, namely, that growth in the wildlife ranching sector is not or does not have the ability to contribute significantly toward economic and socioeconomic factors.

  5. Campbelling-type theory of fission chamber signals generated by neutron chains in a multiplying medium

    International Nuclear Information System (INIS)

    Pál, L.; Pázsit, I.

    2015-01-01

    The signals of fission chambers are usually evaluated with the help of the co-called Campbelling techniques. These are based on the Campbell theorem, which states that if the primary incoming events, generating the detector pulses, are independent, then relationships exist between the moments of various orders of the signal in the current mode. This gives the possibility to determine the mean value of the intensity of the detection events, which is proportional to the static flux, from the higher moments of the detector current, which has certain advantages. However, the main application area of fission chambers is measurements in power reactors where, as is well known, the individual detection events are not independent, due to the branching character of the neutron chains (neutron multiplication). Therefore it is of interest to extend the Campbelling-type theory for the case of correlated neutron events. Such a theory could address two questions: partly, to investigate the bias when the traditional Campbell techniques are used for correlated incoming events; and partly, to see whether the correlation properties of the detection events, which carry information on the multiplying medium, could be extracted from the measurements. This paper is devoted to the investigation of these questions. The results show that there is a potential possibility to extract the same information from fission chamber signals in the current mode as with the Rossi- or Feynman-alpha methods, or from coincidence and multiplicity measurements, which so far have required detectors working in the pulse mode. It is also shown that application of the standard Campbelling techniques to neutron detection in multiplying systems does not lead to an error for estimating the stationary flux as long as the detector is calibrated in in situ measurements

  6. Use of maximum entropy principle with Lagrange multipliers extends the feasibility of elementary mode analysis.

    Science.gov (United States)

    Zhao, Quanyu; Kurata, Hiroyuki

    2010-08-01

    Elementary mode (EM) analysis is potentially effective in integrating transcriptome or proteome data into metabolic network analyses and in exploring the mechanism of how phenotypic or metabolic flux distribution is changed with respect to environmental and genetic perturbations. The EM coefficients (EMCs) indicate the quantitative contribution of their associated EMs and can be estimated by maximizing Shannon's entropy as a general objective function in our previous study, but the use of EMCs is still restricted to a relatively small-scale networks. We propose a fast and universal method that optimizes hundreds of thousands of EMCs under the constraint of the Maximum entropy principle (MEP). Lagrange multipliers (LMs) are applied to maximize the Shannon's entropy-based objective function, analytically solving each EMC as the function of LMs. Consequently, the number of such search variables, the EMC number, is dramatically reduced to the reaction number. To demonstrate the feasibility of the MEP with Lagrange multipliers (MEPLM), it is coupled with enzyme control flux (ECF) to predict the flux distributions of Escherichia coli and Saccharomycescerevisiae for different conditions (gene deletion, adaptive evolution, temperature, and dilution rate) and to provide a quantitative understanding of how metabolic or physiological states are changed in response to these genetic or environmental perturbations at the elementary mode level. It is shown that the ECF-based method is a feasible framework for the prediction of metabolic flux distribution by integrating enzyme activity data into EMs to genetic and environmental perturbations. Copyright 2010 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  7. Blastogenic response of human lymphocytes to early antigen(s) of human cytomegalovirus.

    OpenAIRE

    Waner, J L; Kong, N; Biano, S

    1983-01-01

    The lymphocytes of asymptomatic, seropositive donors demonstrated blastogenic responses to early antigens of human cytomegalovirus whether or not antibodies to early antigens were detectable. The lymphocytes of six of nine patients with active cytomegalovirus infections gave stimulation indexes of greater than or equal to 2.00 with antigens of productively infected cells, whereas only two patients demonstrated comparable stimulation indexes with early antigens. Four patients with stimulation ...

  8. Antigenic cartography of H1N1 influenza viruses using sequence-based antigenic distance calculation.

    Science.gov (United States)

    Anderson, Christopher S; McCall, Patrick R; Stern, Harry A; Yang, Hongmei; Topham, David J

    2018-02-12

    The ease at which influenza virus sequence data can be used to estimate antigenic relationships between strains and the existence of databases containing sequence data for hundreds of thousands influenza strains make sequence-based antigenic distance estimates an attractive approach to researchers. Antigenic mismatch between circulating strains and vaccine strains results in significantly decreased vaccine effectiveness. Furthermore, antigenic relatedness between the vaccine strain and the strains an individual was originally primed with can affect the cross-reactivity of the antibody response. Thus, understanding the antigenic relationships between influenza viruses that have circulated is important to both vaccinologists and immunologists. Here we develop a method of mapping antigenic relationships between influenza virus stains using a sequence-based antigenic distance approach (SBM). We used a modified version of the p-all-epitope sequence-based antigenic distance calculation, which determines the antigenic relatedness between strains using influenza hemagglutinin (HA) genetic coding sequence data and provide experimental validation of the p-all-epitope calculation. We calculated the antigenic distance between 4838 H1N1 viruses isolated from infected humans between 1918 and 2016. We demonstrate, for the first time, that sequence-based antigenic distances of H1N1 Influenza viruses can be accurately represented in 2-dimenstional antigenic cartography using classic multidimensional scaling. Additionally, the model correctly predicted decreases in cross-reactive antibody levels with 87% accuracy and was highly reproducible with even when small numbers of sequences were used. This work provides a highly accurate and precise bioinformatics tool that can be used to assess immune risk as well as design optimized vaccination strategies. SBM accurately estimated the antigenic relationship between strains using HA sequence data. Antigenic maps of H1N1 virus strains reveal

  9. Purification of nonlipopolysaccharide antigen from Brucella abortus during preparation of antigen used for indirect hemolysis test.

    OpenAIRE

    Hoffmann, E M; Houle, J J

    1986-01-01

    The indirect hemolysis test (IHLT) for the diagnosis of brucellosis uses a lipopolysaccharide (LPS) antigen obtained by dimethyl sulfoxide extraction of Brucella abortus. We showed that a non-LPS antigen can be obtained as a by-product of the IHLT antigen preparation. The antigen was purified to homogeneity by a combination of gel-filtration chromatography and ion-exchange chromatography. The substance contained 8% protein and about 65% carbohydrate. The molecular weight of the primary unit w...

  10. Combination of cancer antigen 125 and carcinoembryonic antigen can improve ovarian cancer diagnosis

    DEFF Research Database (Denmark)

    Sørensen, Sofie Sølvsten; Mosgaard, Berit Jul

    2011-01-01

    The purpose of the present study was to evaluate the ability of the tumour marker carcinoembryonic antigen (CEA) in combination with cancer antigen 125 (CA-125) to differentiate between malignant ovarian and malignant non-ovarian disease.......The purpose of the present study was to evaluate the ability of the tumour marker carcinoembryonic antigen (CEA) in combination with cancer antigen 125 (CA-125) to differentiate between malignant ovarian and malignant non-ovarian disease....

  11. A computational framework for influenza antigenic cartography.

    Science.gov (United States)

    Cai, Zhipeng; Zhang, Tong; Wan, Xiu-Feng

    2010-10-07

    Influenza viruses have been responsible for large losses of lives around the world and continue to present a great public health challenge. Antigenic characterization based on hemagglutination inhibition (HI) assay is one of the routine procedures for influenza vaccine strain selection. However, HI assay is only a crude experiment reflecting the antigenic correlations among testing antigens (viruses) and reference antisera (antibodies). Moreover, antigenic characterization is usually based on more than one HI dataset. The combination of multiple datasets results in an incomplete HI matrix with many unobserved entries. This paper proposes a new computational framework for constructing an influenza antigenic cartography from this incomplete matrix, which we refer to as Matrix Completion-Multidimensional Scaling (MC-MDS). In this approach, we first reconstruct the HI matrices with viruses and antibodies using low-rank matrix completion, and then generate the two-dimensional antigenic cartography using multidimensional scaling. Moreover, for influenza HI tables with herd immunity effect (such as those from Human influenza viruses), we propose a temporal model to reduce the inherent temporal bias of HI tables caused by herd immunity. By applying our method in HI datasets containing H3N2 influenza A viruses isolated from 1968 to 2003, we identified eleven clusters of antigenic variants, representing all major antigenic drift events in these 36 years. Our results showed that both the completed HI matrix and the antigenic cartography obtained via MC-MDS are useful in identifying influenza antigenic variants and thus can be used to facilitate influenza vaccine strain selection. The webserver is available at http://sysbio.cvm.msstate.edu/AntigenMap.

  12. Image Reconstruction Algorithm For Electrical Capacitance Tomography (ECT)

    International Nuclear Information System (INIS)

    Arko

    2001-01-01

    ). Most image reconstruction algorithms for electrical capacitance tomography (ECT) use sensitivity maps as weighting factors. The computation is fast, involving a simple multiply-and- accumulate (MAC) operation, but the resulting image suffers from blurring due to the soft-field effect of the sensor. This paper presents a low cost iterative method employing proportional thresholding, which improves image quality dramatically. The strategy for implementation, computational cost, and achievable speed is examined when using a personal computer (PC) and Digital Signal Processor (DSP). For PC implementation, Watcom C++ 10.6 and Visual C++ 5.0 compilers were used. The experimental results are compared to the images reconstructed by commercially available software. The new algorithm improves the image quality significantly at a cost of a few iterations. This technique can be readily exploited for online applications

  13. Diagnostic Values of Carcinoembryonic Antigen, Cancer Antigen 15-3 and Cancer Antigen 125 Levels in Nipple Discharge.

    Science.gov (United States)

    Zhao, Song; Gai, Xiaodong; Wang, Yongmei; Liang, Weili; Gao, Haidong; Zhang, Kai; Wang, Huimin; Liu, Yanhong; Wang, Jianli; Ma, Rong

    2015-12-31

    An expedient and cost-effective diagnostic tool is needed to complement galactography and exfoliative cytology for detection of benign or malignant breast diseases with nipple discharge. The aim of this prospective study is to explore the utility of carcinoembryonic antigen, cancer antigen 15-3 and cancer antigen 125 levels in nipple discharge for the diagnosis of various breast diseases. We evaluated the pre-operative tumor marker levels in 153 nipple discharge samples collected from one or both breasts of 142 women undergoing surgery. Patients with nipple discharge underwent auxiliary examination (ultrasonography, exfoliative cytology, ductoscopy and galactography). Statistically higher levels of carcinoembryonic antigen and cancer antigen 15-3 were found in patients in the malignant group as compared to those in the benign group. No statistically significant difference in the level of cancer antigen 125 (P = 0.895). Sensitivities of carcinoembryonic antigen and cancer antigen 15-3 for diagnosing breast cancer were 74.42% and 58.14%, and specificities were 87.27% and 80.00% where as the cutoff values with max-sum of sensitivity and specificity were 224.3 ng/ml and 1368.2 U/ml, respectively. The following sensitivities for telling malignant from benign could be determined: exfoliative cytology 46.67%, ultrasonography 76.74%, galactography 75.00%, and ductoscopy 0%. Exfoliative cytology was found to be a valuable alternative method for differentiating benign from malignancy. Thus, tumor marker analysis of nipple discharge fluid for carcinoembryonic antigen and cancer antigen 15-3 would enhance the accurate assessment and treatment planning for patients with nipple discharge.

  14. A sequential quadratic programming algorithm using an incomplete solution of the subproblem

    Energy Technology Data Exchange (ETDEWEB)

    Murray, W. [Stanford Univ., CA (United States). Systems Optimization Lab.; Prieto, F.J. [Universidad `Carlos III` de Madrid (Spain). Dept. de Estadistica y Econometria

    1993-05-01

    We analyze sequential quadratic programming (SQP) methods to solve nonlinear constrained optimization problems that are more flexible in their definition than standard SQP methods. The type of flexibility introduced is motivated by the necessity to deviate from the standard approach when solving large problems. Specifically we no longer require a minimizer of the QP subproblem to be determined or particular Lagrange multiplier estimates to be used. Our main focus is on an SQP algorithm that uses a particular augmented Lagrangian merit function. New results are derived for this algorithm under weaker conditions than previously assumed; in particular, it is not assumed that the iterates lie on a compact set.

  15. Maximum entropy algorithm and its implementation for the neutral beam profile measurement

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Wook; Cho, Gyu Seong [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Cho, Yong Sub [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    A tomography algorithm to maximize the entropy of image using Lagrangian multiplier technique and conjugate gradient method has been designed for the measurement of 2D spatial distribution of intense neutral beams of KSTAR NBI (Korea Superconducting Tokamak Advanced Research Neutral Beam Injector), which is now being designed. A possible detection system was assumed and a numerical simulation has been implemented to test the reconstruction quality of given beam profiles. This algorithm has the good applicability for sparse projection data and thus, can be used for the neutral beam tomography. 8 refs., 3 figs. (Author)

  16. The generation algorithm of arbitrary polygon animation based on dynamic correction

    Directory of Open Access Journals (Sweden)

    Hou Ya Wei

    2016-01-01

    Full Text Available This paper, based on the key-frame polygon sequence, proposes a method that makes use of dynamic correction to develop continuous animation. Firstly we use quadratic Bezier curve to interpolate the corresponding sides vector of polygon sequence consecutive frame and realize the continuity of animation sequences. And then, according to Bezier curve characteristic, we conduct dynamic regulation to interpolation parameters and implement the changing smoothness. Meanwhile, we take use of Lagrange Multiplier Method to correct the polygon and close it. Finally, we provide the concrete algorithm flow and present numerical experiment results. The experiment results show that the algorithm acquires excellent effect.

  17. Red cell alloimmunization and infectious marker status (human immunodeficiency virus, hepatitis B virus and hepatitis C virus in multiply transfused thalassemia patients of North India

    Directory of Open Access Journals (Sweden)

    Raj Nath Makroo

    2013-01-01

    Full Text Available Background: Patients with thalassemia major are largely transfusion dependent and are thus exposed to a variety of risks such as transmission of infectious diseases, iron overload and alloimmunization. This study was performed to determine the prevalence of human immune deficiency virus (HIV, hepatitis B virus (HBV, hepatitis C virus (HCV and red cell antibodies among multiple-transfused thalassemic patients in and around the national capital region. Materials and Methods: The Department of Transfusion Medicine, Indraprastha Apollo Hospitals, conducted this study in collaboration with the National Thalassemia Welfare Society over a period of 1 year starting February2011. Blood samples from the patients were tested for blood group, red cell alloantibody/ies, anti-HIV, anti-HCV and hepatitis B surface antigen (HBsAg by ELISA and for the respective viral ribonucleic acid (RNA or deoxyribonucleic acid (DNA by nucleic acid testing (NAT. Results: A total of 462 thalassemics which consists of 290 males and 172 females were tested. The overall alloimmunization rate was 4.1% and anti-Kell was the most common antibody identified. Thirteen cases (2.8% were positive for HBsAg by ELISA, 107 (23.1% were reactive for anti HCV and 11 (2.38% for anti HIV antibodies. Further screening and discriminatory assays by NAT confirmed the presence of HBV DNA in 11 cases, HIV RNA in 7 cases and HCV RNA in 48 cases. Conclusion: In spite of advances in Immunohematology and infectious marker testing in recent years, the rates of alloimmunization and infectious marker positivity remains high among multiply transfused patients like thalassemics. Provision of safe and adequate blood supply to these patients is a key to improving their quality-of-life and longevity.

  18. Monoclonal antibodies against rat leukocyte surface antigens

    NARCIS (Netherlands)

    van den Berg, T. K.; Puklavec, M. J.; Barclay, A. N.; Dijkstra, C. D.

    2001-01-01

    Monoclonal antibodies have proven to be powerful tools for studying the properties of leukocyte surface antigens and the cells that express them. In the past decades many monoclonal antibodies (mAb) for identifying the different rat leukocyte surface antigens have been described. A list of mAb is

  19. Prostate-Specific Antigen (PSA) Test

    Science.gov (United States)

    ... antigen level New England Journal of Medicine 2004;350(22):2239-2246. [PubMed Abstract] Barry ... antigen testing for early diagnosis of prostate cancer. New England Journal of Medicine 2001;344(18):1373-1377. [PubMed Abstract] Pinsky ...

  20. Evaluation of an Antigen-Antibody

    African Journals Online (AJOL)

    GB

    1. ABSTRACT. BACKGROUND: Development of “combination” assays detecting in parallel, within a single test,. Hepatitis C Virus (HCV) antigens and antibodies, not ... considered above threshold of detection for antigen proteins suggested a lack of sensitivity by this assay ..... Hepatic veno-occlusive disease (sinusoidal.

  1. Virosomes for antigen and DNA delivery

    NARCIS (Netherlands)

    Daemen, T; de Mare, A; Bungener, L; de Jonge, J; Huckriede, A; Wilschut, J

    2005-01-01

    Specific targeting and delivery as well as the display of antigens on the surface of professional antigen-presenting cells (APCs) are key issues in the design and development of new-generation vaccines aimed at the induction of both humoral and cell-mediated immunity. Prophylactic vaccination

  2. Vaccination and antigenic drift in influenza.

    Science.gov (United States)

    Boni, Maciej F

    2008-07-18

    The relationship between influenza antigenic drift and vaccination lies at the intersection of evolutionary biology and public health, and it must be viewed and analyzed in both contexts simultaneously. In this paper, 1 review what is known about the effects of antigenic drift on vaccination and the effects of vaccination on antigenic drift, and I suggest some simple ways to detect the presence of antigenic drift in seasonal influenza data. If antigenic drift occurs on the time scale of a single influenza season, it may be associated with the presence of herd immunity at the beginning of the season and may indicate a need to monitor for vaccine updates at the end of the season. The relationship between antigenic drift and vaccination must also be viewed in the context of the global circulation of influenza strains and the seeding of local and regional epidemics. In the data sets I consider--from New Zealand, New York, and France--antigenic drift can be statistically detected during some seasons, and seeding of epidemics appears to be endogenous sometimes and exogenous at other times. Improved detection of short-term antigenic drift and epidemic seeding would significantly benefit influenza monitoring efforts and vaccine selection.

  3. Prediction of Individual Muscle Forces Using Lagrange Multipliers Method - A Model of the Upper Human Limb in the Sagittal Plane: I. Theoretical Considerations.

    Science.gov (United States)

    Raikova, ROSITSA

    2000-01-01

    Analytical solutions of indeterminate problems formulated for biomechanical models with more than one degree of freedom (DOF) are rarely found. This paper is an extension of the investigations of a 1 DOF model (Raikova, 1996, J. Biomechanics, 763-772) for a more complex 3 DOF model. The proposed model of the human upper limb is in the sagittal plane and includes ten muscle elements, four of them being two-joint ones. The formulated optimization task is solved analytically using the method of Lagrange multipliers. It is supposed that the optimization function is complex but can be approximated by a weighted sum of the squared muscle forces, where the nature of the weight factors of the muscles are unknown. The proposed computational algorithm for determination of the unknown individual muscle forces and joint reactions is easily implemented and may be extended without difficulties for more DOF and muscles. The aim is to establish a means of investigation of the possible weight coefficients for different modelled situations, which will help in searching for their physiological interpretation and analytical description.

  4. Finite-element methods for the streamfunction-vorticity equations: Boundary-condition treatments and multiply connected domains

    International Nuclear Information System (INIS)

    Gunzburger, M.D.; Peterson, J.S.

    1988-01-01

    Finite-element methods for the approximation of the solution of streamfunction-vorticity equations are considered. Among the issues dealt with are multiply connected domains, the use of low-order elements, the incorporation of a variety of boundary conditions into the methodology, error estimates, and the recovery of the primitive variables. Various numerical examples are also provided

  5. Design and Analysis of Broad-Band Fixed-Tuned Submillimeter-Waveguide Multipliers using MMIC Style Circuit Topology

    Science.gov (United States)

    Bruston, J.; Kim, M.; Martin, S. C.; Mehdi, I.; Smith, R. P.; Siegel, P. H.

    1996-01-01

    The design and analysis of varactor diode doubler, quadrupler and cascaded doubler circuits for 320 and 640 GHz have been completed. A new approach has been employed to produce a tunerless waveguide mount with a very flexible, frequency scaleable, MMIC style multiplier circuit. The concept, design, predicted performance and measurements on some of the constituent mount elements are presented.

  6. A Lagrange multiplier-type test for idiosyncratic unit roots in the exact factor model under misspecification

    NARCIS (Netherlands)

    Zhou, X.; Solberger, M.

    2013-01-01

    We consider an exact factor model and derive a Lagrange multiplier-type test for unit roots in the idiosyncratic components. The asymptotic distribution of the statistic is derived under the misspecification that the differenced factors are white noise. We prove that the asymptotic distribution is

  7. Trainable Mentally Impaired/Severely Multiply Impaired/Autistic Impaired/Severely Mentally Impaired. Product Evaluation Report 1989-1990.

    Science.gov (United States)

    Claus, Richard N.; And Others

    The evaluation report describes special education services provided to trainable mentally impaired (TMI), autistic impaired (AI), severely multiply impaired (SXI), and severely mentally impaired (SMI) students at and through the Melvin G. Millet Learning Center (Bridgeport, Michigan). The eight program components are described individually and…

  8. Approximate iterative algorithms

    CERN Document Server

    Almudevar, Anthony Louis

    2014-01-01

    Iterative algorithms often rely on approximate evaluation techniques, which may include statistical estimation, computer simulation or functional approximation. This volume presents methods for the study of approximate iterative algorithms, providing tools for the derivation of error bounds and convergence rates, and for the optimal design of such algorithms. Techniques of functional analysis are used to derive analytical relationships between approximation methods and convergence properties for general classes of algorithms. This work provides the necessary background in functional analysis a

  9. Autonomous Star Tracker Algorithms

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Kilsgaard, Søren

    1998-01-01

    Proposal, in response to an ESA R.f.P., to design algorithms for autonomous star tracker operations.The proposal also included the development of a star tracker breadboard to test the algorithms performances.......Proposal, in response to an ESA R.f.P., to design algorithms for autonomous star tracker operations.The proposal also included the development of a star tracker breadboard to test the algorithms performances....

  10. Protein antigen delivery by gene gun-mediated epidermal antigen incorporation (EAI).

    Science.gov (United States)

    Scheiblhofer, Sandra; Ritter, Uwe; Thalhamer, Josef; Weiss, Richard

    2013-01-01

    The gene gun technology can not only be employed for efficient transfer of gene vaccines into upper layers of the skin, but also for application of protein antigens. As a tissue rich in professional antigen presenting cells, the skin represents an attractive target for immunizations. In this chapter we present a method for delivery of the model antigen ovalbumin into the skin of mice termed epidermal antigen incorporation and describe in detail how antigen-specific proliferation in draining lymph nodes can be followed by flow cytometry.

  11. Multiply charged ions of the oxygen - produced at interaction of laser radiation with two-element solids

    International Nuclear Information System (INIS)

    Bedilov, M.R.; Bedilov, R.M.; Kamalova, J.O.; Davletov, I.Yu.; Matnazarov, A.R.

    2007-01-01

    Full text: The interest to study of the oxygen multiply charged ions spectra produced at interaction laser radiation with one and two-element solids, is associate with possibility of creating laser and inertial thermonuclear syntheses, effective sources of multiply charged ions and nuclei atoms elements, plasma lasers, lasers on multiply charged transition, design of radiation-resistant materials and others. The present time many works is devoted to multiply charged ions, obtained from one element targets. Experimental results of study charge and energy spectra multiply charged ions of the oxygen, formed at interaction laser radiation with one and two-element solids are given in this work. Our experiments, we used installation, which is described in [1]. Neodymium laser had following parameters: wavelength 1.06 μm; intensity q = (0.1 h 1000) GW/sm 2 ; angle of incidence = 180. Were study one element Al, and two-element Al 2 O 3 , Y 2 O 3 targets by a diameter of 10 mm and thickness of 3 mm. Analysis obtained charge and energy spectra of multiply charged ions one (Al) and two-element (Al 2 O 3 , Y 2 O 3 ) targets depending on intensity of laser radiation and targets components reveal the following: - maximal charge number one element target (Al) at q 500 GW/sm 2 is equal Z max = 6 and all peaks corresponding to charge numbers Z = 1 - 6 well resolved, but two-element targets (Al 2 O 3 ) Z max ions Al decrease before 3. Also it is necessary to note that, Z max ions of the oxygen depend on target components. In case Al 2 O 3 and Y 2 O 3 maximal charge number of oxygen ions are equal Z max = 6 and 3, accordingly; - obtained charge and energy spectra of oxygen ions being included in two-element targets, are indicative of that, general regularities of the change Z max , E max and structures charge and energy spectra depending on q laser are saved. However they hang by target components; - common features and some differences of energy spectra multiply charged oxygen ions

  12. A verified LLL algorithm

    NARCIS (Netherlands)

    Divasón, Jose; Joosten, Sebastiaan; Thiemann, René; Yamada, Akihisa

    2018-01-01

    The Lenstra-Lenstra-Lovász basis reduction algorithm, also known as LLL algorithm, is an algorithm to find a basis with short, nearly orthogonal vectors of an integer lattice. Thereby, it can also be seen as an approximation to solve the shortest vector problem (SVP), which is an NP-hard problem,

  13. THE ANTIGEN-SPECIFIC CELL IN VITRO TESTS FOR POST-VACCINATION ANTIPLAGUE IMMUNITY FORMATION

    Directory of Open Access Journals (Sweden)

    A. N. Kulichenko

    2017-01-01

    Full Text Available The possibility of post-vaccination anti-plague immunity evaluation was researched using antigen-stimulated cells tests in vitro and cytometry analysis. The object of study — the blood samples of 17 people immunised by the live plague vaccine (Yersinia pestis EV epicutaneously. Blood taking was carried out before vaccination and after immunisation on 7 and on 21 days, in 3 and in 6 months. Intensity antigen reactivity of lymphocytes was detected by cell tests in vitro, analysing markers of early (CD45+CD3+CD25+ and late (CD45+CD3+HLA-DR+ lymphocyte activation using flow cytometry. The complex of water-soluble Y. pestis antigens and allergen — pestin PP was tested as antigen. The high stimulating potential was defined of the water-soluble antigens Y. pestis complex. It is shown that coefficient of stimulation of relative level T- lymphocytes which express receptors for IL-2 was positive for all observation times after immunisation. The coefficient of stimulation had maximum values at 21 days (56.37% and at 3 (47.41% months. In identifying HLADR-positive lymphocytes before vaccination, the negative coefficient of stimulation was indicated on 7 and 21 days and the positive coefficient of stimulation was indicated at 3 and at 6 months. Analysis of intensity expression of early and late lymphocyte activation markers dynamics showed the possibility and prospect of application of cellular in vitro tests for the laboratory evaluation of specific reactivity of cellular immunity in both the early (7 days and late (6 months periods after vaccination. The results can be the basis for developing a new algorithm for assessment of immunological effectiveness of vaccination people against plague. It is the algorithm based on the identification of lymphocyte activation markers by antigen stimulation in conditions in vitro.

  14. A deterministic annealing algorithm for approximating a solution of the linearly constrained nonconvex quadratic minimization problem.

    Science.gov (United States)

    Dang, Chuangyin; Liang, Jianqing; Yang, Yang

    2013-03-01

    A deterministic annealing algorithm is proposed for approximating a solution of the linearly constrained nonconvex quadratic minimization problem. The algorithm is derived from applications of a Hopfield-type barrier function in dealing with box constraints and Lagrange multipliers in handling linear equality constraints, and attempts to obtain a solution of good quality by generating a minimum point of a barrier problem for a sequence of descending values of the barrier parameter. For any given value of the barrier parameter, the algorithm searches for a minimum point of the barrier problem in a feasible descent direction, which has a desired property that the box constraints are always satisfied automatically if the step length is a number between zero and one. At each iteration, the feasible descent direction is found by updating Lagrange multipliers with a globally convergent iterative procedure. For any given value of the barrier parameter, the algorithm converges to a stationary point of the barrier problem. Preliminary numerical results show that the algorithm seems effective and efficient. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. A reconstruction algorithms for helical cone-beam SPECT

    International Nuclear Information System (INIS)

    Weng, Y.; Zeng, G.L.; Gullberg, G.T.

    1993-01-01

    Cone-beam SPECT provides improved sensitivity for imaging small organs like the brain and heart. However, current cone-beam tomography with the focal point traversing a planar orbit does not acquire sufficient data to give an accurate reconstruction. In this paper, the authors employ a data-acquisition method which obtains complete data for cone-beam SPECT by simultaneously rotating the gamma camera and translating the patient bed, so that cone-beam projections can be obtained with the focal point traversing a helix surrounding the patient. An implementation of Grangeat's algorithm for helical cone-beam projections is developed. The algorithm requires a rebinning step to convert cone-beam data to parallel-beam data which are then reconstructed using the 3D Radon inversion. A fast new rebinning scheme is developed which uses all of the detected data to reconstruct the image and properly normalizes any multiply scanned data. This algorithm is shown to produce less artifacts than the commonly used Feldkamp algorithm when applied to either a circular planar orbit or a helical orbit acquisition. The algorithm can easily be extended to any arbitrary orbit

  16. Nature-inspired optimization algorithms

    CERN Document Server

    Yang, Xin-She

    2014-01-01

    Nature-Inspired Optimization Algorithms provides a systematic introduction to all major nature-inspired algorithms for optimization. The book's unified approach, balancing algorithm introduction, theoretical background and practical implementation, complements extensive literature with well-chosen case studies to illustrate how these algorithms work. Topics include particle swarm optimization, ant and bee algorithms, simulated annealing, cuckoo search, firefly algorithm, bat algorithm, flower algorithm, harmony search, algorithm analysis, constraint handling, hybrid methods, parameter tuning

  17. Trimetallic nanostructures: the case of AgPd-Pt multiply twinned nanoparticles

    Science.gov (United States)

    Khanal, Subarna; Bhattarai, Nabraj; Velázquez-Salazar, J. Jesús; Bahena, Daniel; Soldano, German; Ponce, Arturo; Mariscal, Marcelo M.; Mejía-Rosales, Sergio; José-Yacamán, Miguel

    2013-11-01

    We report the synthesis, structural characterization, and atomistic simulations of AgPd-Pt trimetallic (TM) nanoparticles. Two types of structure were synthesized using a relatively facile chemical method: multiply twinned core-shell, and hollow particles. The nanoparticles were small in size, with an average diameter of 11 nm and a narrow distribution, and their characterization by aberration corrected scanning transmission electron microscopy allowed us to probe the structure of the particles at an atomistic level. In some nanoparticles, the formation of a hollow structure was also observed, that facilitates the alloying of Ag and Pt in the shell region and the segregation of Ag atoms on the surface, affecting the catalytic activity and stability. We also investigated the growth mechanism of the nanoparticles using grand canonical Monte Carlo simulations, and we have found that Pt regions grow at overpotentials on the AgPd nanoalloys, forming 3D islands at the early stages of the deposition process. We found very good agreement between the simulated structures and those observed experimentally.We report the synthesis, structural characterization, and atomistic simulations of AgPd-Pt trimetallic (TM) nanoparticles. Two types of structure were synthesized using a relatively facile chemical method: multiply twinned core-shell, and hollow particles. The nanoparticles were small in size, with an average diameter of 11 nm and a narrow distribution, and their characterization by aberration corrected scanning transmission electron microscopy allowed us to probe the structure of the particles at an atomistic level. In some nanoparticles, the formation of a hollow structure was also observed, that facilitates the alloying of Ag and Pt in the shell region and the segregation of Ag atoms on the surface, affecting the catalytic activity and stability. We also investigated the growth mechanism of the nanoparticles using grand canonical Monte Carlo simulations, and we have

  18. Parallel sorting algorithms

    CERN Document Server

    Akl, Selim G

    1985-01-01

    Parallel Sorting Algorithms explains how to use parallel algorithms to sort a sequence of items on a variety of parallel computers. The book reviews the sorting problem, the parallel models of computation, parallel algorithms, and the lower bounds on the parallel sorting problems. The text also presents twenty different algorithms, such as linear arrays, mesh-connected computers, cube-connected computers. Another example where algorithm can be applied is on the shared-memory SIMD (single instruction stream multiple data stream) computers in which the whole sequence to be sorted can fit in the

  19. VISUALIZATION OF PAGERANK ALGORITHM

    OpenAIRE

    Perhaj, Ervin

    2013-01-01

    The goal of the thesis is to develop a web application that help users understand the functioning of the PageRank algorithm. The thesis consists of two parts. First we develop an algorithm to calculate PageRank values of web pages. The input of algorithm is a list of web pages and links between them. The user enters the list through the web interface. From the data the algorithm calculates PageRank value for each page. The algorithm repeats the process, until the difference of PageRank va...

  20. Digital Arithmetic: Division Algorithms

    DEFF Research Database (Denmark)

    Montuschi, Paolo; Nannarelli, Alberto

    2017-01-01

    implement it in hardware to not compromise the overall computation performances. This entry explains the basic algorithms, suitable for hardware and software, to implement division in computer systems. Two classes of algorithms implement division or square root: digit-recurrence and multiplicative (e.......g., Newton–Raphson) algorithms. The first class of algorithms, the digit-recurrence type, is particularly suitable for hardware implementation as it requires modest resources and provides good performance on contemporary technology. The second class of algorithms, the multiplicative type, requires...