Diagnosing avian influenza infection in vaccinated populations by systems for differentiating infected from vaccinated animals (DIVA).

Science.gov (United States)

Capua, I; Cattoli, G

2007-01-01

Vaccination against avian influenza is recommended as a tool to support control measures in countries affected by avian influenza. Vaccination is known to increase the resistance of susceptible birds to infection and also to reduce shedding; however, it does not always prevent infection. Vaccinated infected flocks can therefore be a source of infection and thus be responsible for the perpetuation of infection. To avoid the spread of infection in a vaccinated population, immunization strategies must allow differentiation of infected from vaccinated animals (DIVA), combined with an appropriate monitoring system. Vaccinated exposed flocks must be identified and managed by restriction policies that include controlled marketing and stamping-out. Several vaccines and diagnostic tests to detect infection in vaccinated populations are available, the tests having various properties and characteristics. In order to achieve eradication, the most appropriate DIVA vaccination strategy must be identified and an appropriate monitoring programme be designed, taking into account risk factors, the epidemiological situation and the socioeconomic implications of the policy.

The DIVA model: A neural theory of speech acquisition and production.

Science.gov (United States)

Tourville, Jason A; Guenther, Frank H

2011-01-01

The DIVA model of speech production provides a computationally and neuroanatomically explicit account of the network of brain regions involved in speech acquisition and production. An overview of the model is provided along with descriptions of the computations performed in the different brain regions represented in the model. The latest version of the model, which contains a new right-lateralized feedback control map in ventral premotor cortex, will be described, and experimental results that motivated this new model component will be discussed. Application of the model to the study and treatment of communication disorders will also be briefly described.

From Star to Diva-writer: The Dynamics of the objects in a Comsumption Society

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Marcio Markendorf

2010-01-01

Full Text Available This article aims to critically evaluate two objects produced by the cultural industry – the star and the diva – with regard to their centrality in the mass culture and in the mass media. The concepts, drawn from both categories, open discussions about the consumption of culture in art and literature, as well as enable a promising analyis on the dynamics of the objects in a consumption society.

Experimental studies on an axisymmetric divertor in DIVA(JFT-2a)

International Nuclear Information System (INIS)

Yamamoto, Shin

1979-03-01

DIVA(JFT-2a) is the first tokamak with an axisymmetric divertor in the world. Objectives of the experiments were i) Plasma production and confinement in a tokamak with a separatrix magnetic surface, and ii) divertor effects on radiation loss and plasma confinement. The results so far are as follows: i) The equilibrium with a separatrix magnetic surface is stable during the discharge. ii) There is an ergodic region near the separatrix magnetic surface due to non-axisymmetric magnetic perturbations. iii) The divertor reduces radiation loss and increases energy confinement time. iv) The divertor does not affect the transport process in the main plasma. (author)

Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza

DEFF Research Database (Denmark)

Uttenthal, Åse; Parida, Satya; Rasmussen, Thomas Bruun

2010-01-01

for the presence of infection. This literature review describes the current knowledge on the use of DIVA diagnostic strategies for three important transboundary animal diseases: foot-and-mouth disease in cloven-hoofed animals, classical swine fever in pigs and avian influenza in poultry....

AquaDiva: Understanding the Link between the Surface and Subsurface Biogeosphere

Science.gov (United States)

Trumbore, S.; Küsel, K.; Totsche, K. U.; Schwab, V.; Herrmann, M.; Nowak, M. E.; Gleixner, G.

2017-12-01

In the collaborative research project AquaDiva, we combine hydrogeochemical, metagemonic and biogeochemical tools to understand how the complex interactions between geologic setting and surface land use influence the function and biodiversity of the subsurface, especially ground water ecosystems. At the Hainich Critical Zone Exploratory in central Germany, we investigate soil and seepage waters in recharge areas and aquifers in a fractured limestone setting characterized by a dynamic water infiltration regime. Within the Exploratory, we have so far identified three distinct biogeochemical zones in which land use and lithologic differences combine to give rise to surprisingly different biotic communities and hydrogeochemical properties with different degrees of connection to the surface. Here we will focus on how we have combined carbon isotopic, organic biomarkers such as phospholipid fatty acids, and `omics' approaches to determine (i) how deep soil-borne microorganisms can be traced into the subsurface, and (ii) which energy sources sustain microbial life in oligotrophic limestone aquifers. With increasing travel distance to the surface, there is a decline in the abundance of microbes, with less than 5% of the taxa identified overlapping with those identified in the soils. Dissolved organic matter also is altered as it passes through soils, demonstrating an overall increase in molecular weight and a change in molecular makeup as well as radiocarbon content. Using the radiocarbon signature (corrected for the influence of carbonate dissolution), as a way to identify if organic C is being supplied recently by plants, atmosphere sources of energy for communities within the aquifer differ for the identified biogeochemical zones and include (i) dominance of inputs of fresh organic carbon from the surface feeding heterotrophy in oxygenic environments; (ii) CO2 fixation linked to nitrogen and sulfur cycling in anoxic environments and (iii) rock-derived organic matter

The evaluation of a nucleoprotein ELISA for the detection of equine influenza antibodies and the differentiation of infected from vaccinated horses (DIVA).

Science.gov (United States)

Galvin, Pamela; Gildea, Sarah; Arkins, Sean; Walsh, Cathal; Cullinane, Ann

2013-12-01

Antibodies against equine influenza virus (EIV) are traditionally quantified by haemagglutination inhibition (HI) or single radial haemolysis (SRH). To evaluate an ELISA for the detection of antibodies against influenza nucleoprotein in the diagnosis and surveillance of equine influenza (EI). The ELISA was compared with the SRH and HI tests. Serial serum samples from 203 naturally and 14 experimentally infected horses, from 60 weanlings following primary vaccination with five different vaccines (two whole inactivated vaccines, two ISCOM-based subunit vaccines and a recombinant canarypox virus vaccine) and from 44 adult horses following annual booster vaccination with six different vaccines were analysed. Fewer seroconversions were detected in clinical samples by ELISA than by SRH or HI but ELISA was more sensitive than SRH in naïve foals post-experimental infection. The ELISA did not detect the antibody response to vaccination with the recombinant canarypox virus vaccine confirming the usefulness of the combination of this kit and vaccine to differentiate between naturally infected and vaccinated horses, that is, DIVA. No DIVA capacity was evident with the other vaccines. The results suggest that this ELISA is a useful supplementary test for the diagnosis of EI although less sensitive than HI or SRH. It is an appropriate test for EI surveillance in a naïve population and may be combined with the recombinant canarypox virus vaccine but not with other commercially available subunit vaccines, in a DIVA strategy. © 2013 Blackwell Publishing Ltd.

Pop divas and feminist identity: vindication, contradiction and cultural

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Silvia Martinez Cano

2017-12-01

Full Text Available The videoclip is a cultural production that is shared through the Internet and media networks, through all kinds of electronic devices for personal and domestic use. It helps to accelerate the predominance of cultural production as a construct agent both of meaning and of entertainment. A visual sequencing that allows an intense perception of a message in a very short period of time. From the phenomena related to the audiovisual production of women artists I will reflect on the performative force of the musical videos of pop divas and the drifts that can become in the social and political demands that occur in them. First, the role of subjectivation in the production and consumption of them. Second, the processes of socialization and performativity that articulate other social imaginaries for women and men and establish a different order in gender discourses. So how they contribute to changes in the production of culture, being also aware of mixed interests in a cultural mainstream environment.

Archaeometrical analysis of Neolithic pottery from the Divača region, Slovenia

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Andreja Žibrat Gašparič

2004-12-01

Full Text Available The results of the mineralogical and chemical analyses of pottery from the Neolithic period from the Divača region are presented. Pottery samples from two rock shelters, i.e. Mala Triglavca and Trhlovca, were included in the analyses, as well as sediment samples from other rock shelters, caves and rivers around this area. The mineralogical and chemical composition of the ceramic is uniform in most of the samples; the differences between the clay pastes of the vessels are in the use of a tempering material, mostly calcite grains. The sediment samples, especially from the cave deposits, point to a local production of the Neolithic pottery on the Karst plateau.

Inferring the biogeographic origins of inter-continental disjunct endemics using a Bayes-DIVA approach

Institute of Scientific and Technical Information of China (English)

AJ HARRIS; Jun WEN; Qiu-Yun (Jenny) XIANG

2013-01-01

The arcto-Tertiary relictual flora is comprised of many genera that occur non-contiguously in the temperate zones of eastern Asia,Europe,eastern North America,and westem North America.Within each distributional area,species are typically endemic and may thus be widely separated from closely related species within the other areas.It is widely accepted that this common pattern of distribution resulted from of the fragmentation of a once morecontinuous arcto-Tertiary forest.The historical biogeographic events leading to the present-day disjunction have often been investigated using a phylogenetic approach.Limitations to these previous studies have included phylogenetic uncertainty and uncertainty in ancestral range reconstructions.However,the recently described Bayes-DIVA method handles both types of uncertainty.Thus,we used Bayes-DIVA analysis to reconstruct the stem lineage distributions for 185 endemic lineages from 23 disjunct genera representing 17 vascular plant families.In particular,we asked whether endemic lineages within each of the four distributional areas more often evolved from (1) widespread ancestors,(2) ancestors dispersed from other areas,or (3) endemic ancestors.We also considered which of these three biogeographic mechanisms may best explain the origins of arcto-Tertiary disjunct endemics in the neotropics.Our results show that eastern Asian endemics more often evolved from endemic ancestors compared to endemics in Europe and eastern and western North America.Present-day endemic lineages in the latter areas more often arose from widespread ancestors.Our results also provide anecdotal evidence for the importance of dispersal in the biogeographic origins of arcto-Tertiary species endemic in the neotropics.

Trabalho imaterial, produção cultural colaborativa e economia da dádiva.

OpenAIRE

Lima, Clóvis Ricardo Montenegro de; Pizarro, Daniella; Faustino, Elisangela; Dittrich, Maireli

2011-01-01

Neste artigo discutem-se as relações entre trabalho imaterial, produção cultural colaborativa e economia da dádiva na sociedade atual. O intelecto geral é relacionado com a inteligência coletiva das redes digitais. A produção colaborativa emerge como forma privilegiada do fazer artístico e cultural. Esta produção pode contribuir para promoção e preservação da diversidade cultural. A produção cultural colaborativa evidencia pluralismo econômico. A generalização do trabalho imate...

Recombinant adenovirus expressing the haemagglutinin of Peste des petits ruminants virus (PPRV) protects goats against challenge with pathogenic virus; a DIVA vaccine for PPR.

Science.gov (United States)

Herbert, Rebecca; Baron, Jana; Batten, Carrie; Baron, Michael; Taylor, Geraldine

2014-02-26

Peste des petits ruminants virus (PPRV) is a morbillivirus that can cause severe disease in sheep and goats, characterised by pyrexia, pneumo-enteritis, and gastritis. The socio-economic burden of the disease is increasing in underdeveloped countries, with poor livestock keepers being affected the most. Current vaccines consist of cell-culture attenuated strains of PPRV, which induce a similar antibody profile to that induced by natural infection. Generation of a vaccine that enables differentiation of infected from vaccinated animals (DIVA) would benefit PPR control and eradication programmes, particularly in the later stages of an eradication campaign and for countries where the disease is not endemic. In order to create a vaccine that would enable infected animals to be distinguished from vaccinated ones (DIVA vaccine), we have evaluated the immunogenicity of recombinant fowlpox (FP) and replication-defective recombinant human adenovirus 5 (Ad), expressing PPRV F and H proteins, in goats. The Ad constructs induced higher levels of virus-specific and neutralising antibodies, and primed greater numbers of CD8+ T cells than the FP-vectored vaccines. Importantly, a single dose of Ad-H, with or without the addition of Ad expressing ovine granulocyte macrophage colony-stimulating factor and/or ovine interleukin-2, not only induced strong antibody and cell-mediated immunity but also completely protected goats against challenge with virulent PPRV, 4 months after vaccination. Replication-defective Ad-H therefore offers the possibility of an effective DIVA vaccine.

The reliability of DIVA test based on M2e peptide exceed those based on HA2 or NS1 peptides

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Simson Tarigan

2015-06-01

Full Text Available One of the most important disadvantage of vaccination against avian influenza is that it cannot protect vaccinated birds against infection. When vaccinated poultry are heavily exposed to the virus, prolonged, unrecognised, subclinical infection may persist on the farm. The condition can only be serologically monitored by a DIVA (differentiation of infected from vaccinated animals test, whereas conventional diagnostic tests cannot be used. The DIVA tests based on an antibody response following virus replication is the most appropriate approach. For H5N1 influenza such antibodies includes those to the M2e and NS1 proteins and an epitope on the HA2 subunit (HA_488-516. The purpose of this study was to compare the magnitude of the antibody response in chickens vaccinated and infected with an H5N1 virus strain. For that purpose, sera collected from naïve, vaccinated and infected birds, at 1, 2-3, ≥4 weeks post challenge were used. Antibodies were measured by ELISA using biotinylated synthetic peptides as coating antigens. The peptides used include four NS1 peptides corresponding to different regions of the NS1 protein and HA_488-516and M2e peptides. Peptides were coated onto microtitre plates either directly or via a streptavidin bridge. The results showed that vaccination did not cause antibody conversion to any of the peptides, where as challenged birds developed a high antibody response to M2e but, low response to the NS1 and HA2 peptides. Antibodies to the later peptides were detected only by the streptavidin-peptide ELISA. The ELISA based on NS1 or HA_488-516 peptides, therefore, are not reliable for use as DIVA test in H5N1 avian influenza virus infection

Third generation DIVA vaccine towards classical swine fever virus. Efficacy in face of maternal immunity

DEFF Research Database (Denmark)

Rangelova, Desislava Yordanova

General purpose and objectives Classical swine fever (CSF) is a highly contagious disease that causes huge economical losses and animal welfare concerns worldwide. Generally, vaccination is an effective and safe method to control the disease. Following vaccination the pig’s immune system develops...... a new DIVA vaccine candidate. The vaccine candidate “CP7E2alf” is intended for either intramuscular vaccination of domestic pig or for bait vaccination of wild boar. In this thesis as part of the clinical testing of the injection vaccine the efficacy of “CP7E2alf” was evaluated in young piglets...

Trabalho imaterial, produção cultural colaborativa e economia da dádiva | Immaterial labour, collaborative cultural production and the economy of the gift

Directory of Open Access Journals (Sweden)

Clóvis Ricardo Montenegro de Lima

2009-09-01

Full Text Available Resumo Neste artigo discutem-se as relações entre trabalho imaterial, produção cultural colaborativa e  economia da dádiva na sociedade atual. O intelecto geral é relacionado com a inteligência coletiva das redes digitais. A produção colaborativa emerge como forma privilegiada do fazer artístico e cultural. Esta produção pode contribuir para promoção e preservação da diversidade cultural. A produção cultural colaborativa evidencia pluralismo econômico. A generalização do trabalho imaterial produz bens comuns. O comum cria a versão pós-industrial e de alta tecnologia da economia da dádiva Conclui-se que a cultura colaborativa tem grande potencial para promover diversidade cultural e economia da generosidade. Palavras-chave trabalho imaterial; produção colaborativa; cultura; economia da dádiva; produção cultural colaborativa. Abstract This article discusses the relationship between immaterial labor, collaborative cultural production and gift economy in society today. The general intellect is related to the collective intelligence of digital networks. The collaborative production emerges as the preferred way to artistic and cultural. This production may contribute to promotion and preservation of cultural diversity. The collaborative cultural production highlights pluralism economics. The spread of immaterial labor produces common assets. The common creates a post-industrial and high-tech version of the gift economy. It is concluded that the collaborative culture has great potential to promote cultural diversity and economy of generosity. Keywords immaterial labor; collaborative production; culture; gift economy; collaborative cultural production.

Dual function of the hemagglutinin H5 fused to chicken CD154 in a potential strategy of DIVA against avian influenza disease: preliminary study

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A.G. Pose

2015-09-01

Full Text Available In this study we demonstrated that the vaccine candidate against avian influenza virus H5N1 based on the hemagglutinin H5 (HA fused to the chicken CD154 (HACD can also be used for differentiating infected from vaccinated animals (DIVA. As the strategy of DIVA requires at least two proteins, we obtained a variant of the nucleoprotein (NP49-375 in E. coli. After its purification by IMAC, the competence of the proteins NP49-375 and HACD as coating antigens in indirect ELISA assays were tested by using the sera of chickens immunized with the proteins HA and HACD and the reference sera from several avian influenza subtypes. Together with these sera, the sera from different species of birds and the sera of chickens infected with other avian viral diseases were analyzed by competition ELISA assays coated with the proteins NP49-375 and HACD. The results showed that the segment CD154 in the chimeric protein HACD did not interfere with the recognition of the molecule HA by its specific antibodies. Also, we observed variable detection levels when the reference sera were analyzed in the ELISA plates coated with the protein NP49-375. Moreover, only the antibodies of the reference serum subtype H5 were detected in the ELISA plates coated with the protein HACD. The competition ELISA assays showed percentages of inhibition of 88-91% for the positives sera and less than 20% for the negative sera. We fixed the cut-off value of these assays at 25%. No antibody detection was observed in the sera from different species of birds or the sera of chickens infected with other avian viral diseases. This study supported the fact that the ELISA assays using the proteins NP49-375 and HACD could be valuable tools for avian influenza surveillance and as a strategy of DIVA for counteracting the highly pathogenic avian influenza virus H5N1 outbreaks.

Dual function of the hemagglutinin H5 fused to chicken CD154 in a potential strategy of DIVA against avian influenza disease: preliminary study.

Science.gov (United States)

Pose, A G; Rodríguez, E S; Méndez, A C; Gómez, J N; Redondo, A V; Rodríguez, E R; Ramos, E M G; Gutiérrez, A Á; Moltó, M P R; Roche, D G; Ugalde, Y S; López, A M

2015-01-01

In this study we demonstrated that the vaccine candidate against avian influenza virus H5N1 based on the hemagglutinin H5 (HA) fused to the chicken CD154 (HACD) can also be used for differentiating infected from vaccinated animals (DIVA). As the strategy of DIVA requires at least two proteins, we obtained a variant of the nucleoprotein (NP49-375) in E. coli. After its purification by IMAC, the competence of the proteins NP49-375 and HACD as coating antigens in indirect ELISA assays were tested by using the sera of chickens immunized with the proteins HA and HACD and the reference sera from several avian influenza subtypes. Together with these sera, the sera from different species of birds and the sera of chickens infected with other avian viral diseases were analyzed by competition ELISA assays coated with the proteins NP49-375 and HACD. The results showed that the segment CD154 in the chimeric protein HACD did not interfere with the recognition of the molecule HA by its specific antibodies. Also, we observed variable detection levels when the reference sera were analyzed in the ELISA plates coated with the protein NP49-375. Moreover, only the antibodies of the reference serum subtype H5 were detected in the ELISA plates coated with the protein HACD. The competition ELISA assays showed percentages of inhibition of 88-91% for the positives sera and less than 20% for the negative sera. We fixed the cut-off value of these assays at 25%. No antibody detection was observed in the sera from different species of birds or the sera of chickens infected with other avian viral diseases. This study supported the fact that the ELISA assays using the proteins NP49-375 and HACD could be valuable tools for avian influenza surveillance and as a strategy of DIVA for counteracting the highly pathogenic avian influenza virus H5N1 outbreaks.

Gift and care during the time lived with the family A dádiva e o cuidado no tempo do vivido em família

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Ítala Paris de Souza

2017-10-01

Full Text Available Objetivo: Compreender a modelagem do cuidado familiar ao longo do tempo à idosa que vivencia o Alzheimer, inscrevendo-o no circuito da dádiva. Métodos: Estudo de situação, de abordagem compreensiva, empregando história de vida com entrevista em profundidade e observação junto à idosa e família. Resultados: Apreendemos os laços que unem os entes familiares, possibilitando a modelagem do cuidado “na e para” a vida, ao longo do tempo em família, instaurando o circuito da dádiva, que apresentamos pela imagem da lemniscata. Nessa modelagem evidenciamos o intenso esforço despendido pela família na provisão e gerenciamento dos cuidados à idosa, cada vez mais aprimorados, reatualizando, assim, o dar-receber-retribuir, em tecitura afetiva e laboriosa. Conclusão: Tal compreensão se mostra importante aos profissionais de saúde para que reflitam sobre modos de produzir boas práticas que perdurem no tempo, mobilizando recursos para apoiar a família com o substrato necessário ao seu cuidar.

Divertor experiment for impurity control in DIVA

International Nuclear Information System (INIS)

Nagami, Masayuki

1979-04-01

Divertor actions of controlling the impurities and the transport of impurity ions in the plasma have been investigated in the DIVA device. Following are the results: (1) The radial transport of impurity ions is not described only by neoclassical theory, but it is strongly influenced by anomalous process. Radial diffusion of impurity ions across the whole minor radius is well described by a neoclassical diffusion superposed by the anomalous diffusion for protons. Due to this anomalous process, which spreads the radial density profile of impurity ions, 80 to 90% of the impurity flux in the plasma outer edge is shielded even in a nondiverted discharge. (2) The divertor reduces the impurity flux entering the main plasma by a factor of 2 to 4. The impurity ions shielded by the scrape-off plasma are rapidly guided into the burial chamber with a poloidal excursion time roughly equal to that of the scrape-off plasma. (3) The divertor reduces the impurity ion flux onto the main vacuum chamber by guiding the impurity ions diffusing from the main plasma into the burial chamber, thereby reducing the plasma-wall interaction caused by diffusing impurity ions at the main vacuum chamber. The impurity ions produced in the burial chamber may flow back to the main plasma through the scrape-off layer. However, roughly only 0.3% of the impurity flux into the scrape-off plasma in the burial chamber penetrates into the main plasma due to the impurity backflow. (4) A slight cooling of the scrape-off plasma with light-impurity injection effectively reduces the metal impurity production at the first wall by reducing the potential difference between the plasma and the wall, thereby reducing the accumulation of the metal impurity in the discharge. Radiation cooling by low-Z impurities in the plasma outer edge, which may become an important feature in future large tokamaks both with and without divertor, is numerically evaluated for carbon, oxygen and neon. (author)

Intermediate rough Brucella abortus S19Δper mutant is DIVA enable, safe to pregnant guinea pigs and confers protection to mice.

Science.gov (United States)

Lalsiamthara, Jonathan; Gogia, Neha; Goswami, Tapas K; Singh, R K; Chaudhuri, Pallab

2015-05-21

Brucella abortus S19 is a smooth strain used as live vaccine against bovine brucellosis. Smooth lipopolysaccharide (LPS) is responsible for its residual virulence and serological interference. Rough mutants defective of LPS are more attenuated but confers lower level of protection. We describe a modified B. abortus S19 strain, named as S19Δper, which exhibits intermediate rough phenotype with residual O-polysaccharide (OPS). Deletion of perosamine synthetase gene resulted in substantial attenuation of S19Δper mutant without affecting immunogenic properties. It mounted strong immune response in Swiss albino mice and conferred protection similar to S19 vaccine. Immunized mice produced higher levels of IFN-γ, IgG2a and thus has immune response inclined towards Th1 cell mediated immunity. Sera from immunized animals did not show agglutination reaction with RBPT antigen and thus could serve as DIVA (Differentiating Infected from Vaccinated Animals) vaccine. S19Δper mutant displayed more susceptibility to serum complement mediated killing and sensitivity to polymyxin B. Pregnant guinea pigs injected with S19Δper mutant completed full term of pregnancy and did not cause abortion, still birth or birth of weak offspring. S19Δper mutant with intermediate rough phenotype displayed remarkable resemblance to S19 vaccine strain with improved properties of safety, immunogenicity and DIVA capability for control of bovine brucellosis. Copyright © 2015 Elsevier Ltd. All rights reserved.

O MITO DA MATINTA PERERA DE TAPERAÇU CAMPO E O CONCEITO DE DÁDIVA: APROXIMANDO-SE DE UM CONCEITO ANTROPOLÓGICO

OpenAIRE

Silva Júnior, Fernando Alves da

2014-01-01

O plano deste artigo tem por objetivo aproximar as narrativas orais sobre a Matinta Perera da comunidade bragantina de Taperaçu Campo aoconceito de dádiva de Marcel Mauss (2003), considerando a pesquisa desenvolvida nessa localidade no decorrer dos anos de 2012 e 2013.Para tanto, utilizaremos os conceitos de Mauss de que há nas relações sociais a tripla obrigação: a de dar, de receber e de retribuir, além disso, aproximaremos essa observação à oferta que se faz a Matinta que, via de regra, sã...

Modeling of severe accident sequences with the new modules CESAR and DIVA of ASTEC system code

International Nuclear Information System (INIS)

Pignet, Sophie; Guillard, Gaetan; Barre, Francois; Repetto, Georges

2003-01-01

Systems of computer codes, so-called 'integral' codes, are being developed to simulate the scenario of a hypothetical severe accident in a light water reactor, from the initial event until the possible radiological release of fission products out of the containment. They couple the predominant physical phenomena that occur in the different reactor zones and simulate the actuation of safety systems by procedures and by operators. In order to allow to study a great number of scenarios, a compromise must be found between precision of results and calculation time: one day of accident time should take less than one day of real time to simulate on a PC computer. This search of compromise is a real challenge for such integral codes. The development of the ASTEC integral code was initiated jointly by IRSN and GRS as an international reference code. The latest version 1.0 of ASTEC, including the new modules CESAR and DIVA which model the behaviour of the reactor cooling system and the core degradation, is presented here. Validation of the modules and one plant application are described

Um trabalho a troco de nada? A ação de uma comunidade de hackers à luz da teoria da dádiva

Directory of Open Access Journals (Sweden)

GENAUTO CARVALHO DE FRANÇA FILHO

2014-08-01

Full Text Available Mais do que apontar possíveis respostas para um "enigma" contemporâneo, este artigo discute as especificidades da dinâmica de trabalho dos hackers, no processo de produção não-contratual e colaborativo, presente na comunidade on-line de desenvolvimento de softwares do Projeto GNOME (GNU Network Object Model Environment. A partir de uma imersão netnográfica de mais de um ano, analisou-se a organização do trabalho que dá vida ao processo de produção empreendido por mais de 300 hackers e colaboradores de todos os cinco continentes do planeta. Mais especificamente, buscou-se compreender a natureza do trabalho adotado pelos hackers ao longo do desenvolvimento e distribuição de softwares nessa comunidade online de abrangência internacional. Como resultado, constatou-se a presença no Projeto GNOME de um tipo de engajamento não-contratual, associado a uma forma de trabalho e circulação de bens que se difere completamente de organizações ligadas à esfera do mercado ou do Estado, mas que consegue, por meio da internet, viabilizar um processo internacional de desenvolvimento de software de alta complexidade. Em outras palavras, foi possível verificar por meio da dinâmica social empreendida no seio dessa comunidade online, a emergência, nos liames digitais da internet, de uma nova expressão da dádiva moderna: um sistema de dádiva mediada por computador, tanto na essência como no modo de funcionamento e organização do trabalho.

A Review of OIE Country Status Recovery Using Vaccinate-to-Live Versus Vaccinate-to-Die Foot-and-Mouth Disease Response Policies I: Benefits of Higher Potency Vaccines and Associated NSP DIVA Test Systems in Post-Outbreak Surveillance.

Science.gov (United States)

Barnett, P V; Geale, D W; Clarke, G; Davis, J; Kasari, T R

2015-08-01

To rapidly return to trade, countries with OIE status, FMD-free country where vaccination is not practised, have destroyed emergency vaccinated animals, raising ethical concerns with respect to social values, the environment, animal welfare and global food security. This two-part review explores whether science could support eligibility to return to previous OIE status in 3 months irrespective of vaccinate-to-live or vaccinate-to-die policies. Here, we examine the benefits of higher potency (≥ 6 PD50 ), high-purity vaccines formulated from antigen banks for emergency use, their efficacy and performance in differentiating infected from vaccinated animals (DIVA) assays for post-outbreak surveillance. From an intensive programme of research, we conclude that high-quality, higher potency vaccines are proven to reduce FMD virus (FMDV) subclinical circulation and the risk of carriers. Broader coverage than predicted by serology suggests the potential to hold a few 'key' vaccine strains improving logistics and reducing the financial burden of antigen banks. The OIE should adopt formal definitions for emergency vaccination and emergency vaccines. In terms of supportive tools, we consider that the lack of OIE recognition of DIVA tests other than those of PANAFTOSA in cattle is a shortcoming. There is need for research on maternal antibody interference with DIVA tests and on the use of such tests to establish whether greater purification of vaccines improves performance. We consider that alignment of waiting periods for vaccinate-to-live and vaccinate-to-die in OIE Code Article 8.5.9 1 b. and c. is feasible until an acceptable level of statistical certainty for surveillance or target probability of freedom is established to substantiate the absence of FMDV infection or circulation. It is surveillance intensity rather than waiting periods that establishes the risk of residual FMDV. EU Directive 2003/85/EC implicitly recognizes this, permitting derogation of the OIE waiting

Harvesting an experiment: observations of bushy landrace winter rye in a small scale experimental slah-and-burn field in Estonia / Kersti Kihno, Liisi Jääts, Mati Laane

Index Scriptorium Estoniae

Kihno, Kersti, 1963-

2015-01-01

13. sajandi alguseks kujunes talirukis Eesti ala tähtsaimaks toiduteraviljaks ning oli 13. - 18. sajandini ka peamine ekspordiartikkel. Alepõllul kasvatatud puhmasrukis andis suuri saake, kuid oli nõudlik maa viljakuse suhtes. Eksperiment toimus Tartumaal. Eksperimendi tulemused kinnitasid ajalooallikate kirjeldusi - soodsates tingimustes on puhmasrukis väga saagikas. Kuigi väiksemõõtmelise eksperimendi tulemusi ei saa käsitleda kui suure alepõllu täpset mudelit, annab see siiski olulist materjali talirukki maasordi kohta, mis on siiani saanud teenimatult vähe tähelepanu

Supra-complete surgery via dual intraoperative visualization approach (DiVA) prolongs patient survival in glioblastoma.

Science.gov (United States)

Eyüpoglu, Ilker Y; Hore, Nirjhar; Merkel, Andreas; Buslei, Rolf; Buchfelder, Michael; Savaskan, Nicolai

2016-05-03

Safe and complete resection represents the first step in the treatment of glioblastomas and is mandatory in increasing the effectiveness of adjuvant therapy to prolong overall survival. With gross total resection currently limited in extent to MRI contrast enhancing areas, the extent to which supra-complete resection beyond obvious contrast enhancement could have impact on overall survival remains unclear. DiVA (dual intraoperative visualization approach) redefines gross total resection as currently accepted by enabling for the first time supra-complete surgery without compromising patient safety. This approach exploits the advantages of two already accepted surgical techniques combining intraoperative MRI with integrated functional neuronavigation and 5-ALA by integrating them into a single surgical approach. We investigated whether this technique has impact on overall outcome in GBM patients. 105 patients with GBM were included. We achieved complete resection with intraoperative MRI alone according to current best-practice in glioma surgery in 75 patients. 30 patients received surgery with supra-complete resection. The control arm showed a median life expectancy of 14 months, reflecting current standards-of-care and outcome. In contrast, patients receiving supra-complete surgery displayed significant increase in median survival time to 18.5 months with overall survival time correlating directly with extent of supra-complete resection. This extension of overall survival did not come at the cost of neurological deterioration. We show for the first time that supra-complete glioma surgery leads to significant prolongation of overall survival time in GBM patients.

Exchange networks and free shops in Berlin: gifts and commodities in ‘alternative’ consumption experiences Redes de intercâmbio e lojas gratuitas em Berlim: dádiva e mercadoria em experiências “alternativas” de consumo

Directory of Open Access Journals (Sweden)

Irene Sabaté Muriel

2009-05-01

Full Text Available This paper is based on an ethnography of ‘alternative’ consumption practices in the inner city of the former East Berlin. Non-monetary exchange networks (Tauschringe and ‘free shops’ (Umsonstläden have been examined. In Umsonstläden, the contemporary ideology of the ‘pure’ gift (Parry 1986; Carrier 1995 is at play: objects are freely given and totally alienated from their owners. In turn, Tauschringe sometimes induce gift-giving practices entailing mutual obligation, as a result of frequent exchanges which bring participants socially closer. The ethnographic material I present challenges the suitability of a conceptual gift/commodity divide to examine these experiences, provided that different modalities of gift-giving are articulated with commoditisation trends. Considering this complexity, I propose a re-examination of the role of the gift in ‘alternative’ consumption practices promoted by social movements in Berlin.O artigo baseia-se numa etnografia de práticas de consumo “alternativas” nos bairros centrais da antiga Berlim-Leste. São aqui analisadas as redes de intercâmbio não monetário (Tauschringe e as “lojas gratuitas” (Umsonstläden. As Umsonstläden são enquadradas pela ideologia contemporânea da dádiva “pura” (Parry 1986; Carrier 1995: os objectos são dados gratuitamente e totalmente alienados dos seus possuidores. Já as Tauschringe, por seu lado, induzem por vezes práticas de oferta que implicam obrigações mútuas, como consequência de trocas frequentes que aproximam socialmente os participantes. O material etnográfico apresentado põe em causa a adequação do binómio dádiva/mercadoria à análise dessas experiências, na medida em que diferentes modalidades de oferta se conjugam com tendências para a mercadorização. Face a essa complexidade, o artigo propõe uma revisão da análise do papel da dádiva em práticas de consumo “alternativas” promovidas pelos movimentos sociais em

Chapitre 8 – Production et qualification de l’espace urbain : entre informel et corruption

OpenAIRE

David, Jean-Claude

2014-01-01

Les habitants/créateurs de quartiers informels à l’est de la ville, sous-produits de l’urbanisme, la jeunesse dorée des quartiers aisés de l’ouest qui fréquente les fast foods et renforce le profond clivage social entre l’est et l’ouest, les réfugiés palestiniens et leurs descendants habitants de deux « camps » à Alep, qui entretiennent leur propre marginalité, les imams originaires de la région rurale d’Alep qui « entrent » dans la ville et l’investissent par la confrérie Nabhaniyya, n’ont p...

Plasma-assisted atomic layer epitaxial growth of aluminum nitride studied with real time grazing angle small angle x-ray scattering

Energy Technology Data Exchange (ETDEWEB)

Anderson, Virginia R.; Nepal, Neeraj; Johnson, Scooter D.; Robinson, Zachary R.; Nath, Anindya; Kozen, Alexander C.; Qadri, Syed B.; DeMasi, Alexander; Hite, Jennifer K.; Ludwig, Karl F.; Eddy, Charles R.

2017-05-01

Wide bandgap semiconducting nitrides have found wide-spread application as light emitting and laser diodes and are under investigation for further application in optoelectronics, photovoltaics, and efficient power switching technologies. Alloys of the binary semiconductors allow adjustments of the band gap, an important semiconductor material characteristic, which is 6.2 eV for aluminum nitride (AlN), 3.4 eV for gallium nitride, and 0.7 eV for (InN). Currently, the highest quality III-nitride films are deposited by metalorganic chemical vapor deposition and molecular beam epitaxy. Temperatures of 900 °C and higher are required to deposit high quality AlN. Research into depositing III-nitrides with atomic layer epitaxy (ALEp) is ongoing because it is a fabrication friendly technique allowing lower growth temperatures. Because it is a relatively new technique, there is insufficient understanding of the ALEp growth mechanism which will be essential to development of the process. Here, grazing incidence small angle x-ray scattering is employed to observe the evolving behavior of the surface morphology during growth of AlN by ALEp at temperatures from 360 to 480 °C. Increased temperatures of AlN resulted in lower impurities and relatively fewer features with short range correlations.

Aletamine maastikukujunduse- ja kultuuritegurina Põhja- Euroopas ja Eestis / Ülle Tarkiainen

Index Scriptorium Estoniae

Tarkiainen, Ülle, 1957-

2014-01-01

Aletamise vormidest. Alesavolastest ja ale põletamisega seotud müütidest. Alepõletamise algusest Eestis. Aletamise kajastumisest 17. sajandi allikmaterjalides. Metsapõldudest viljatootmise ja uusasustuse ressursina. Aletamise marginaliseerumisest.

Proteomic and immunoproteomic characterization of a DIVA subunit vaccine against Actinobacillus pleuropneumoniae

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Maas Alexander

2011-04-01

Full Text Available Abstract Background Protection of pigs by vaccination against Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is hampered by the presence of 15 different serotypes. A DIVA subunit vaccine comprised of detergent-released proteins from A. pleuropneumoniae serotypes 1, 2 and 5 has been developed and shown to protect pigs from clinical symptoms upon homologous and heterologous challenge. This vaccine has not been characterized in-depth so far. Thus we performed i mass spectrometry in order to identify the exact protein content of the vaccine and ii cross-serotype 2-D immunoblotting in order to discover cross-reactive antigens. By these approaches we expected to gain results enabling us to argue about the reasons for the efficacy of the analyzed vaccine. Results We identified 75 different proteins in the vaccine. Using the PSORTb algorithm these proteins were classified according to their cellular localization. Highly enriched proteins are outer membrane-associated lipoproteins like OmlA and TbpB, integral outer membrane proteins like FrpB, TbpA, OmpA1, OmpA2, HgbA and OmpP2, and secreted Apx toxins. The subunit vaccine also contained large amounts of the ApxIVA toxin so far thought to be expressed only during infection. Applying two-dimensional difference gel electrophoresis (2-D DIGE we showed different isoforms and variations in expression levels of several proteins among the strains used for vaccine production. For detection of cross-reactive antigens we used detergent released proteins of serotype 7. Sera of pigs vaccinated with the detergent-released proteins of serotypes 1, 2, and 5 detected seven different proteins of serotype 7, and convalescent sera of pigs surviving experimental infection with serotype 7 reacted with 13 different proteins of the detergent-released proteins of A. pleuropneumoniae serotypes 1, 2, and 5. Conclusions A detergent extraction-based subunit vaccine of A. pleuropneumoniae was

evaluation of the leave and bud decoctions pinus halepensis mill ...

African Journals Online (AJOL)

31 déc. 2014 ... L'espèce Pinus halepensis Mill (ou pin d'Alep), appartenant à la famille des Pinaceae, a ... au moyen d'un moulin électrique à usage domestique (model Moulinex D5001) au niveau du ..... central ltaly Flavour Frag. J., 2003 ...

Philometrids (Nematoda: Philometridae) in carangid and serranid fishes off New Caledonia, including three new species

Czech Academy of Sciences Publication Activity Database

Moravec, František; Justine, J.-L.

2014-01-01

Roč. 21, MAY 19 2014 (2014), s. 21 ISSN 1252-607X R&D Projects: GA ČR GBP505/12/G112 Institutional support: RVO:60077344 Keywords : Parasitic nematode * Philometra * Marine fish * Alepes * Epinephelus * Selar * New Caledonia Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 1.092, year: 2014

Moralidade, dádiva e sociação: Uma análise a partir dos grupos de ajuda mútua Alcoólicos Anônimos

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Eduardo Tadeu Brunello

2017-12-01

Full Text Available O objetivo deste artigo é analisar a produção de um senso de moralidade a partir dos discursos circulantes nos grupos de Alcoólicos Anônimos (AA, mas, concomitantemente, explorar as possibilidades de agência dos atores por meio das “sociações” (SIMMEL, 2006 emergentes destas plataformas terapêuticas. Para tanto, utilizo como hipótese a ideia de que esse senso de moralidade é construído por meio de atividades externas e coercitivas (acerca dos discursos sobre a doença para, em um segundo momento, desconstruí-lo no plano das interações face a face da dádiva e das sociações. The aim of Morality, Gift and Sociation: An Analysis from the Mutual Alcoholic Assistance Groups Anonymous is to analyze the production of a sense of morality from the current talks in groups of Alcoholics Anonymous (AA, but concurrently explore the possibilities of agency of the actors through the "sociations" (SIMMEL, 2006 emerging from these therapeutic platforms. For this, I use as a hypothesis the idea that this sense of morality is built through external and coercive activities (about speeches on the disease for, second, deconstruct it in terms of face-to-face gift interactions and sociations.Keywords: associations, morality, alcoholism, gift, Alcoholics Anonymous

Genetic Diversity of Some Capparis L. Species Growing in Syria

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Bassam Al- Safadi

2014-12-01

Full Text Available This work investigated the genetic diversity and relationships among Capparis species growing in Syria using IRAP and ISSR techniques. Forty-seven samples of three Capparis species genotypes were collected from 21 different locations in Syria. The genotypes were morphologically identified based on the descriptions available in the literature. When IRAP technique was used, an average of 71.5% of the amplified fragments were polymorphic compared to 82.04% in ISSR. Morphological characterization along with the cluster and PCoA analyses of the data divided the studied genotypes into three groups. The groups included genotypes identified as Capparis spinosa L, C. sicula Duh., and C. aegyptia Lam. Based on the morphological description, molecular studies and statistical analyses of this study, C. aegyptia could be suggested as a separate species and not a varietal rank of C. spinosa(C. spinosa var. aegyptia (Lam.. Two samples (Alep1 and Idl were not placed in any of the three distinctive groups, despite their closeness morphologically to C. spinosa. In PCoA analysis, sample Alep1 came between C. sicula and C. spinosa and Idl was placed between C. sicula and C. aegyptia. Although hybridization between Capparis species could occur, it was not clear from the present study if these two genotypes were hybrids.

Entropy-Based Model for Interpreting Life Systems in Traditional Chinese Medicine

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Guo-lian Kang

2008-01-01

Full Text Available Traditional Chinese medicine (TCM treats qi as the core of the human life systems. Starting with a hypothetical correlation between TCM qi and the entropy theory, we address in this article a holistic model for evaluating and unveiling the rule of TCM life systems. Several new concepts such as acquired life entropy (ALE, acquired life entropy flow (ALEF and acquired life entropy production (ALEP are propounded to interpret TCM life systems. Using the entropy theory, mathematical models are established for ALE, ALEF and ALEP, which reflect the evolution of life systems. Some criteria are given on physiological activities and pathological changes of the body in different stages of life. Moreover, a real data-based simulation shows life entropies of the human body with different ages, Cold and Hot constitutions and in different seasons in North China are coincided with the manifestations of qi as well as the life evolution in TCM descriptions. Especially, based on the comparative and quantitative analysis, the entropy-based model can nicely describe the evolution of life entropies in Cold and Hot individuals thereby fitting the Yin–Yang theory in TCM. Thus, this work establishes a novel approach to interpret the fundamental principles in TCM, and provides an alternative understanding for the complex life systems.

Evaluation of CSFV Antibody ELISAs for the differentiation of infected from vacci-nated animals

DEFF Research Database (Denmark)

Schroeder, Sabine; Blome, Sandra; Koenen, Frank

countries and out-breaks occurred recently e.g. in Germany, France, Hungary, Romania, Bulgaria, and the Slovak Republic. Preventive vaccination is prohibited within the EU, but emergency vaccination can be part of the strategy in case of a contingency. Using conventional vaccines, differentiation...... of vaccinated from infected animals (DIVA) is not possible. Newly developed modified live marker vaccines allow a DIVA strategy based on the use of enzyme linked immunosorbent assay (ELISA) tests. The aim of this study was to evaluate CSF virus (CSFV) Antibody ELISAs, com-mercially available in Europe......, for their diagnostic sensitivity as well as for their potential in differentiating between infected and marker vaccinated animals. Two newly available ELISAs were included into the tests, the Priocheck® CSFV Erns ELISA, a special DIVA test, and the LDL Pigtype® CSFV Antibody ELISA. An inter-laboratory comparison test...

Real-time growth study of plasma assisted atomic layer epitaxy of InN films by synchrotron x-ray methods

Energy Technology Data Exchange (ETDEWEB)

Nepal, Neeraj [U.S. Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375; Anderson, Virginia R. [American Society for Engineering Education, 1818 N Street NW, Washington, DC 20036; Johnson, Scooter D. [U.S. Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375; Downey, Brian P. [U.S. Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375; Meyer, David J. [U.S. Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375; DeMasi, Alexander [Physics Department, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215; Robinson, Zachary R. [Department of Physics, SUNY College at Brockport, 350 New Campus Dr, Brockport, New York 14420; Ludwig, Karl F. [Physics Department, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215; Eddy, Charles R. [U.S. Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375

2017-03-13

The temporal evolution of high quality indium nitride (InN) growth by plasma-assisted atomic layer epitaxy (ALEp) on a-plane sapphire at 200 and 248 °C was probed by synchrotron x-ray methods. The growth was carried out in a thin film growth facility installed at beamline X21 of the National Synchrotron Light Source at Brookhaven National Laboratory and at beamline G3 of the Cornell High Energy Synchrotron Source, Cornell University. Measurements of grazing incidence small angle x-ray scattering (GISAXS) during the initial cycles of growth revealed a broadening and scattering near the diffuse specular rod and the development of scattering intensities due to half unit cell thick nucleation islands in the Yoneda wing with correlation length scale of 7.1 and 8.2 nm, at growth temperatures (Tg) of 200 and 248 °C, respectively. At about 1.1 nm (two unit cells) of growth thickness nucleation islands coarsen, grow, and the intensity of correlated scattering peak increased at the correlation length scale of 8.0 and 8.7 nm for Tg = 200 and 248 °C, respectively. The correlated peaks at both growth temperatures can be fitted with a single peak Lorentzian function, which support single mode growth. Post-growth in situ x-ray reflectivity measurements indicate a growth rate of ~0.36 Å/cycle consistent with the growth rate previously reported for self-limited InN growth in a commercial ALEp reactor. Consistent with the in situ GISAXS study, ex situ atomic force microscopy power spectral density measurements also indicate single mode growth. Electrical characterization of the resulting film revealed an electron mobility of 50 cm2/V s for a 5.6 nm thick InN film on a-plane sapphire, which is higher than the previously reported mobility of much thicker InN films grown at higher temperature by molecular beam epitaxy directly on sapphire. These early results indicated that in situ synchrotron x-ray study of the epitaxial growth kinetics of InN films is a very powerful method to

Systematic study on dynamic atomic layer epitaxy of InN on/in +c-GaN matrix and fabrication of fine-structure InN/GaN quantum wells: Role of high growth temperature

Science.gov (United States)

Yoshikawa, Akihiko; Kusakabe, Kazuhide; Hashimoto, Naoki; Hwang, Eun-Sook; Imai, Daichi; Itoi, Takaomi

2016-12-01

The growth kinetics and properties of nominally 1-ML (monolayer)-thick InN wells on/in +c-GaN matrix fabricated using dynamic atomic layer epitaxy (D-ALEp) by plasma-assisted molecular beam epitaxy were systematically studied, with particular attention given to the effects of growth temperature. Attention was also given to how and where the ˜1-ML-thick InN layers were frozen or embedded on/in the +c-GaN matrix. The D-ALEp of InN on GaN was a two-stage process; in the 1st stage, an "In+N" bilayer/monolayer was formed on the GaN surface, while in the 2nd, this was capped by a GaN barrier layer. Each process was monitored in-situ using spectroscopic ellipsometry. The target growth temperature was above 620 °C and much higher than the upper critical epitaxy temperature of InN (˜500 °C). The "In+N" bilayer/monolayer tended to be an incommensurate phase, and the growth of InN layers was possible only when they were capped with a GaN layer. The InN layers could be coherently inserted into the GaN matrix under self-organizing and self-limiting epitaxy modes. The growth temperature was the most dominant growth parameter on both the growth process and the structure of the InN layers. Reflecting the inherent growth behavior of D-ALEp grown InN on/in +c-GaN at high growth temperature, the embedded InN layers in the GaN matrix were basically not full-ML in coverage, and the thickness of sheet-island-like InN layers was essentially either 1-ML or 2-ML. It was found that these InN layers tended to be frozen at the step edges on the GaN and around screw-type threading dislocations. The InN wells formed type-I band line-up heterostructures with GaN barriers, with exciton localization energies of about 300 and 500 meV at 15 K for the 1-ML and 2-ML InN wells, respectively.

Digital fluorography and computed tomography in a department of neuroradiology - a comparative study

International Nuclear Information System (INIS)

Fawcitt, R.A.; Freer, C.; Jarvis, H.; Occleshaw, J.V.; Isherwood, I.

1984-01-01

Digital Subtraction Angiography (DSA) has the ability to display the intracranial circulation following an intravenous or intra-arterial injection of contrast medium. A study was performed in 57 patients with neurological disorders undergoing DSA, either by Digital Intravenous Injection Angiography (DIVA) or Digital Intra-arterial Injection Angiography (DART) to assess the ability of DIVA to replace DART, the latter being carried out by digital fluorography or by conventional film screen methods, and also to establish the role of DSA in relation to Computed Tomography. (U.K.)

Geologic data management at AVO: building authoritative coverage with radical availability (Invited)

Science.gov (United States)

Cameron, C.; Snedigar, S. F.; Nye, C. J.

2009-12-01

In 2002, the Alaska Volcano Observatory (AVO) began creating the Geologic Database of Information on Volcanoes in Alaska (GeoDIVA) to create a system that contains complete, flexible, timely, and accurate geologic and geographic information on Pleistocene and younger volcanoes in Alaska. This system was primarily intended to be a tool for scientific investigation, crisis response, and public information - delivered in a dynamic, digital format to both internal and external users. It is now the back-end of the AVO public website. GeoDIVA does not interface with our daily monitoring activities, however -- seismic and satellite data are handled by different database efforts. GeoDIVA also doesn’t store volcanic unrest data, although we hope WOVOdat will. GeoDIVA does include modules for the following datasets: bibliography (every subsequent piece of data in GeoDIVA is tied to a reference), basic volcano information (~137 edifices), historical eruption history information (~550 events), images (~17,000), sample information (~4400), geochemistry (~1500; population in progress), petrography (very early stages of data creation), sample storage (~14,000), and Quaternary vent information (~1200 vents). Modules in progress include GIS data, tephra data, and geochronologic data. In recent years, we have been doing maintenance work on older modules (for example, adding new references to the bibliography, and creating new queries and data fields in response to user feedback) as well as developing, designing, and populating new modules. Population can be quite time consuming, as there are no pre-compiled comprehensive existing sources for most information on Alaskan volcanoes, and we carefully reference each item. Newer modules also require more complex data arrangements than older modules. To meet the needs of a diverse group of users on widely varying computer platforms, GeoDIVA data is primarily stored in a MySQL DBMS; PostGIS/PostgreSQL are currently used to store and

Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus.

Science.gov (United States)

Lihoradova, Olga A; Indran, Sabarish V; Kalveram, Birte; Lokugamage, Nandadeva; Head, Jennifer A; Gong, Bin; Tigabu, Bersabeh; Juelich, Terry L; Freiberg, Alexander N; Ikegami, Tetsuro

2013-01-01

Rift Valley fever virus (RVFV; genus Phlebovirus, family Bunyaviridae) is a mosquito-borne zoonotic pathogen which can cause hemorrhagic fever, neurological disorders or blindness in humans, and a high rate of abortion in ruminants. MP-12 strain, a live-attenuated candidate vaccine, is attenuated in the M- and L-segments, but the S-segment retains the virulent phenotype. MP-12 was manufactured as an Investigational New Drug vaccine by using MRC-5 cells and encodes a functional NSs gene, the major virulence factor of RVFV which 1) induces a shutoff of the host transcription, 2) inhibits interferon (IFN)-β promoter activation, and 3) promotes the degradation of dsRNA-dependent protein kinase (PKR). MP-12 lacks a marker for differentiation of infected from vaccinated animals (DIVA). Although MP-12 lacking NSs works for DIVA, it does not replicate efficiently in type-I IFN-competent MRC-5 cells, while the use of type-I IFN-incompetent cells may negatively affect its genetic stability. To generate modified MP-12 vaccine candidates encoding a DIVA marker, while still replicating efficiently in MRC-5 cells, we generated recombinant MP-12 encoding Punta Toro virus Adames strain NSs (rMP12-PTNSs) or Sandfly fever Sicilian virus NSs (rMP12-SFSNSs) in place of MP-12 NSs. We have demonstrated that those recombinant MP-12 viruses inhibit IFN-β mRNA synthesis, yet do not promote the degradation of PKR. The rMP12-PTNSs, but not rMP12-SFSNSs, replicated more efficiently than recombinant MP-12 lacking NSs in MRC-5 cells. Mice vaccinated with rMP12-PTNSs or rMP12-SFSNSs induced neutralizing antibodies at a level equivalent to those vaccinated with MP-12, and were efficiently protected from wild-type RVFV challenge. The rMP12-PTNSs and rMP12-SFSNSs did not induce antibodies cross-reactive to anti-RVFV NSs antibody and are therefore applicable to DIVA. Thus, rMP12-PTNSs is highly efficacious, replicates efficiently in MRC-5 cells, and encodes a DIVA marker, all of which are

Toward a sustainable waste management system: a comprehensive assessment of thermal and electric energy recovery from waste incineration

Energy Technology Data Exchange (ETDEWEB)

Salvia, Monica; Cosmi, Carmelina; Cuomo, Vincenzo; Macchiato, Maria [Istituto Nazionale per la Fisica della Materia, Napoli (Italy); Mangiamele, Lucia [Univ. della Basilicata, Potenza (Italy). Dipt. Ingegneria e Fisica dell Ambiente; Pietrapertosa, Filomena [Univ. di Napoli Federico II, (Italy). Dipt. di Scienze Fisiche

2002-12-01

Energy-environmental planning must join normative, environmental and socio-economic features to obtain effective strategies aimed to a sustainable development. Therefore a comprehensive methodology for the analysis and the optimisation of the anthropogenic activities system configuration, can usefully support decision-makers in the definition of harmonised sector plans, joining waste management issues with resource use problems and exploiting energy and materials feedback among supply and demand sectors. In this paper we present an innovative application of the Advanced Local Energy Environmental Planning methodology (ALEP), aimed to the definition of optimal waste management strategies which comply with comprehensive as well as sectorial issues.

ABOUT POTENTIALLY ACCEPTABLE TRACTION OF THE UNEXPECTED PHENOMENON

Directory of Open Access Journals (Sweden)

BOL’SHAKOV V. I.

2017-05-01

Full Text Available Summary. Raising of problem. The article notes that constructive denial of traditional beliefs is often a powerful source of scientific discoveries. However, the absence of a constructive negation of the diva phenomenon can not be perceived as a lack of an adequate interpretation of it. It is assumed that the interpretation of Diva phenomena can be based on the definition of the area of their existence, which is computationally irreducible within the boundaries of existing methods of identification. The definition of such an area initiates. The formation of hypotheses that interpret the assumptions about its existence. An example of the origin of one of the hypotheses is considered in this essay. Drawing on relativistic physics and cosmology, the authors put forward a hypothesis about the possibility of the existence of a parallel space-time continuum to the existing one. This allows us to assume the existence of fragments of diva-type phenomena shifted in time to the main such continuum. The presence of such a phenomenon allows one to assume a mental connection of the percipient to a parallel space-time continuum and to implement time-shifted predictions. As an example, the existence of a computationally irreducible region of a concrete psychophysical phenomenon (sculptural portraying is given.

The effect of radiation on the conservation of Alep pine and mycotoxins

International Nuclear Information System (INIS)

Chokri, Monjia

2005-01-01

The purpose of this study is to investigate the effect of irradiation on pinus halepensis quality (microbiological quality, physico-chemical and rheological characteristics), on the mycotoxins: ochratoxin A and on its conservation. The pinus halepensis of three origins (Kef, Kasserine and Thibar) are treated with different doses (0, 0.5, 1, 1.5 and 2.5 kGy) and microbiological, physico-chemical and rheological analyses are done in order to show the effect of this treatement and to have the dose of decimal reduction (DDR) of total aeorobics flora mesophyl of pinus halepensis of every origin. When the DDR was determined, the pinus halepensis of every origin are irradieted with 0 Kgy and with 3 Kgy, and the pinus halepensis of Kasserine is irradieted with 2 Kgy and the pinus halepensis of Kef and Thibar are treated with 1 Kgy. We are steady some parameter of caracterisation of pinus halepensis in its storage at 20 0 Cand 37 0 Cduring 4 months. The results obtained show that the irradiation is very performant on reducing the number of bacteria. In fact the dose of 1 Kgy permits the complete elimination of the germs of fecal contamination and yeasts and the moulds. Thus, the increase of the dose of the dose of irradition causes modification in physico-chemical properties of pinus halepensis. For mycotoxins, irradiation has showed good results. In fact 2 Kgy permit the destruction of 90 % d'OTA present in the pinus halepensis of Kef, 30 % d'OTA present in the pinus halepensis of Kasserine and 16 % d'OTA present in the pinus halepensis of Thibar, or the dose of 3 KGy permit the complete elimination of OTAof the samples of pinus halepensis and one dose of 5 Kgy eliminate complitely the OTA produced by the Aspergillus ochraceus. (Author)

Development of a Blocking ELISA Using a Monoclonal Antibody to a Dominant Epitope in Non-Structural Protein 3A of Foot-and-Mouth Disease Virus, as a Matching Test for a Negative-Marker Vaccine.

Directory of Open Access Journals (Sweden)

Yuanfang Fu

Full Text Available Foot-and-mouth disease (FMD is a devastating animal disease. Strategies for differentiation of infected from vaccinated animals (DIVA remain very important for controlling disease. Development of an epitope-deleted marker vaccine and accompanying diagnostic method will improve the efficiency of DIVA. Here, a monoclonal antibody (Mab was found to recognize a conserved "AEKNPLE" epitope spanning amino acids 109-115 of non-structural protein (NSP 3A of foot-and-mouth disease virus (FMDV; O/Tibet/CHA/99 strain, which could be deleted by a reverse-genetic procedure. In addition, a blocking ELISA was developed based on this Mab against NSP 3A, which could serve as a matching test for a negative-marker vaccine. The criterion of this blocking ELISA was determined by detecting panels of sera from different origins. The serum samples with a percentage inhibition (PI equal or greater than 50% were considered to be from infected animals, and those with <50% PI were considered to be from non-infected animals. This test showed similar performance when compared with other 2 blocking ELISAs based on an anti-NSP 3B Mab. This is the first report of the DIVA test for an NSP antibody based on an Mab against the conserved and predominant "AEKNPLE" epitope in NSP 3A of FMDV.

Cultivar e adubação NPK na produção de tomate salada Cultivar and NPK fertilization on yield of fresh market tomato

Directory of Open Access Journals (Sweden)

Paulo Renato Z. Santos

2001-03-01

Full Text Available O objetivo deste trabalho foi estudar o efeito de cultivar, da adubação NPK e da interação desses fatores na produção de tomate salada tutorado. O experimento foi conduzido em Pelotas (RS no ano agrícola 1995/96. Foram utilizadas cinco cultivares (Flora-Dade, Max, Empire, Pacific e Diva e três níveis (2,0, 3,5 e 5,0 t/ha de adubação NPK (3,6-7,2-10. Os tratamentos foram dispostos sob esquema fatorial em delineamento de blocos casualizados, com três repetições. As cultivares Empire e Pacific apresentaram frutos com maior peso médio do que Flora-Dade, Max e Diva. O número de frutos por planta aumentou com a elevação do nível de adubação de 2,0 para 3,5 t/ha, enquanto que o peso médio de frutos diminuiu, sem alterar a produção. As cultivares apresentaram respostas diferenciais aos níveis de adubação, em relação ao peso médio de frutos.The objective of this work was to study the effect of cultivar, NPK fertilization and the interaction on yield components of fresh market tomatoes. The experiment was carried out in Pelotas, Brazil, in 1995/96 season. Five cultivars (Flora-Dade, Max, Empire, Pacific and Diva and three fertilization levels (2.0, 3.5 and 5.0 t/ha of NPK (3.6-7.2-10 were used. The treatments were displayed under a factorial scheme, in a randomized complete block design, with three repetitions. Empire and Pacific cultivars showed higher average fruit weight than Flora-Dade, Max and Diva. The number of fruits per plant increased with the elevation of fertilization levels from 2.0 to 3.5 t/ha, while the average fruit weight diminished, without changing yield. The cultivars showed differential response to fertilization levels, in relation to average fruit weight.

A DÁDIVA DA AGRESSÃO

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MARIA DO SOCORRO LACERDA LIMA

2009-12-01

Full Text Available On the context of Tupinambá war, bodies, trophies, women, children, names, words, identities, aggressions, offenses, and a lot more richness material that from the changing elements moving on permanently among enemy groups. But on the contrary, the potlatch held on the American northwest, where the alliance establishes a mutual relation of favors between not enemy groups. On the context of Tupi war, the changing system is based exactly in a hostilerelation among opposite groups. The aim of the present article is to establish a parallel between anthropophagic complexes of Tupinambá Indians and established potlatch on the American’s northwest societies analyzed by Marcel Mauss.RESUMO: No contexto da guerra tupinambá corpos, troféus, mulheres, crianças, nomes, palavras, identidades, agressões, ofensas e muitas outras riquezas materiais e imateriais se constituem em elementos de troca que circulam perpetuamente entre grupos inimigos. Mas, aocontrário do que ocorre no Potlatch realizado no noroeste americano, em que a aliança estabelece uma relação mútua de prestações entre grupos não inimigos, no contexto da guerra Tupi o sistema de trocas baseia-se exatamente na relação hostil entre grupos contrários. Oobjetivo do presente artigo é tecer um paralelo entre o complexo antropofágico dos índios Tupinambá e o Potlatch estabelecido entre as sociedades do Noroeste Americano analisadas por Marcel Mauss.

Recent results in the DIVA experiment

International Nuclear Information System (INIS)

1978-03-01

Divertor effects have been studied over a wide range of plasma parameters: electron temperature T sub(eo) = 200 - 700 eV, ion temperature T sub(io) = 60 - 300 eV and density n sub(eo) = (1.5 - 8.0) x 10 13 cm -3 in the main plasma, and T sub(es) = 20 - 100 eV, T sub(is) = 20 - 60 eV and n sub(es) = (1.5 - 5.0) x 10 12 cm -3 in the scrape-off layer plasma. The following results are obtained. 1) The divertor reduces plasma-wall interactions near the main plasma by guiding loss plasma into the divertor chamber. A maximum divertor efficiency is 35% for particle flux and 75% for heat flux. 2) The scrape-off layer plasma shields impurity influx, guides ionized impurities into the divertor, and reduces influx of injected impurities into the main plasma by a factor of 2 - 4. Shielding efficiency is higher for aluminum than for carbon. Shielding effect is also observed in a conventional discharge. 3) The divertor reduces radiation loss by a factor of 2 - 4 and hence increases the energy-confinement time by a factor of 2.5. 4) The divertor does not significantly affect particle-confinement time, ion temperature and heat diffusion coefficient. 5) The radiation loss due to pseudo continuum mainly from gold ions is comparable to that due to oxygen lines. Impurity confinement time is comparable to the average particle-confinement time. 6) The particle flow velocity is a few times less than the sound velocity, the heat transmission rate is consistent with a sheath model, and the particle diffusion coefficient in the scrape-off layer is about ten times less than the Bohm diffusion coefficient. Scaling for electron temperature is obtained. 7) Ion sputtering, arcing and evaporation are identified. The ion sputtering by impurity ions is the dominant process of metallic impurity release from a limiter or a neutralizer plate in a stable discharge. (J.P.N.)

The vaccines for Bovine Herpesvirus Type 1: A review

African Journals Online (AJOL)

Administrator

2011-09-05

Sep 5, 2011 ... disease, causing great economic losses in the livestock industry. Vaccine is a ... virus vaccines. Key words: BoHV-1, vaccine, DIVA, recombinant virus. ... may cause latent infection and immune suppression. (Yates, 1982).

Sluglett Peter with Weber Stefan (éd., Syria and Bilad al-Sham under Ottoman Rule. Essays in honour of Abdul-Karim Rafeq, Leyde, Brill, 2010, 633 p.

Directory of Open Access Journals (Sweden)

Catherine Mayeur-Jaouen

2013-10-01

Full Text Available Un an avant le printemps arabe de 2011 qui coïncida avec son quatre-vingtième annniversaire, le grand historien syrien Abdulkarim Rafeq s’était vu offrir en 2010 ce beau volume de Mélanges, fruit d’un colloque tenu en 2004 à Damas et à Beyrouth. La cohérence de l’œuvre de Rafeq (l’histoire du Bilād al-Shām ottoman à travers les archives dont il est un connaisseur hors pair comme le caractère bilingue de sa formation (Collège américain à Alep, Université syrienne à Damas, un doctorat à la SOA...

[Role of vaccination in animal health].

Science.gov (United States)

Pastoret, Paul-Pierre

2012-03-01

According to the IFAH, veterinary vaccines currently account for 26% of the global market in veterinary medicines, reflecting the importance of vaccines in animal health, as well as the number of wild and domesticated target species, and the monospecific nature of most vaccines. Multispecies vaccines include tetanus and rabies. In 2010, the number of food-producing animals was estimated to be roughly 20 billion and is rising gradually. Fowl currently represent the main food species. Veterinary vaccination has allowed the eradication of rinderpest, as officially declared last year (2011), jointly by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation of the United Nations (FAO). Rinderpest was a real scourge, and was only the second viral disease to be totally eradicated (after human smallpox). One characteristic of veterinary vaccination is the DIVA approach, "differentiating infected from vaccinated animals". The DIVA strategy is especially interesting for regulated control of diseases like foot-and-mouth disease, infectious bovine rhinotracheitis, pseudorabies, and classical swine fever. DIVA vaccination requires prior serological testing. Vaccination is also used for wild animals such as foxes (rabies) and wild boars (classical swine fever). "In ovo" vaccination of fowl on day 18 of the incubation period is used to prevent Marek's disease for instance, and double vaccination (vector and insert) to prevent both Marek's disease and Gumboro's disease in fowl. Animal vaccination can also help to protect human health, as illustrated by fowl vaccination against salmonellosis.

Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial

NARCIS (Netherlands)

Beishuizen, Cathrien R. L.; Coley, Nicola; Moll van Charante, Eric P.; van Gool, Willem A.; Richard, Edo; Andrieu, Sandrine

2017-01-01

To explore and compare sociodemographic, clinical, and neuropsychiatric determinants of dropout and nonadherence in older people participating in an open-label cluster-randomized controlled trial-the Prevention of Dementia by Intensive Vascular care (preDIVA) trial-over 6 years. Secondary analysis.

Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial

NARCIS (Netherlands)

Beishuizen, C.R.; Coley, N.; Charante, E.P.M. van; Gool, W.A. van; Richard, E.; Andrieu, S.

2017-01-01

OBJECTIVES: To explore and compare sociodemographic, clinical, and neuropsychiatric determinants of dropout and nonadherence in older people participating in an open-label cluster-randomized controlled trial-the Prevention of Dementia by Intensive Vascular care (preDIVA) trial-over 6 years. DESIGN:

Archaeology of lighthouses along the Indian coast with reference to a lighthouse at Kodinar, Gujarat

Digital Repository Service at National Institute of Oceanography (India)

Gaur, A; Sundaresh

monuments like temples were used as markers of coasts by navigators since early times Recent exploration near Kodinar revealed a structure with a height of abut 4 m and circular in shape It is locally called Diva Dandi, which means lighthouse The shape...

Diagnosis aids with artificial intelligence in the PSAD system

International Nuclear Information System (INIS)

Dourgnon-Hanoune, A.; Porcheron, M.; Ricard, B.

1996-01-01

To improve monitoring and diagnosis capabilities in nuclear power plants, Electricite de France (EDF) has designed an integrated monitoring and diagnosis assistance system: PSAD - Poste de Surveillance et d'Aide au Diagnostic. The development of this sophisticated monitoring and data processing system requires the addition of analysis and diagnosis assistance capabilities. Diagnostic knowledge based systems have thus been added to the functions monitored in PSAD: DIVA for turbine generators, and DIAPO for reactor coolant pumps. These systems rely on a representation of the diagnostic reasoning process of experts and of supporting knowledge. Diagnosis in both systems is performed through an abductive reasoning process applied to component fault models and observations derived from their actual behavior, as provided by the monitoring functions. The basic theoretical elements of this diagnostic model are summarized in a first part of this paper. In a second part, DIVA and DIAPO specific elements are described. (authors)

Plaadid / Valner Valme

Index Scriptorium Estoniae

Valme, Valner, 1970-

2003-01-01

Uutest plaatidest "Nu Divas 2", New Cool Collective "Bring It On", Kait Tamra "Kõigel on kõigega seos", "Gangs Of New York", george Strait "For The Last Time - Live From The Astrodome", Will Smith "greatest Hits", Sulo "Kuumad tunded", The Donnas "Spend The Night"

On the radulae and spines of some Polyplacophora and Archaeogastropoda from Curaçao

NARCIS (Netherlands)

Righi, Gilberto

1968-01-01

During her stay at Curaçao from December 1965 to March 1966 Prof. Dr. DIVA DINIZ CORRÊA collected several groups of marine invertebrates. I should like to thank her for having entrusted me with the Polyplacophora and Archaeogastropoda for further study of radulae and spines.

Evolution of Western Mediterranean Sea Surface Temperature between 1985 and 2005: a complementary study in situ, satellite and modelling approaches

Science.gov (United States)

Troupin, C.; Lenartz, F.; Sirjacobs, D.; Alvera-Azcárate, A.; Barth, A.; Ouberdous, M.; Beckers, J.-M.

2009-04-01

In order to evaluate the variability of the sea surface temperature (SST) in the Western Mediterranean Sea between 1985 and 2005, an integrated approach combining geostatistical tools and modelling techniques has been set up. The objectives are: underline the capability of each tool to capture characteristic phenomena, compare and assess the quality of their outputs, infer an interannual trend from the results. Diva (Data Interpolating Variationnal Analysis, Brasseur et al. (1996) Deep-Sea Res.) was applied on a collection of in situ data gathered from various sources (World Ocean Database 2005, Hydrobase2, Coriolis and MedAtlas2), from which duplicates and suspect values were removed. This provided monthly gridded fields in the region of interest. Heterogeneous time data coverage was taken into account by computing and removing the annual trend, provided by Diva detrending tool. Heterogeneous correlation length was applied through an advection constraint. Statistical technique DINEOF (Data Interpolation with Empirical Orthogonal Functions, Alvera-Azc

Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial.

Science.gov (United States)

Polson, Sally; Taylor, Polly M; Yates, David

2012-08-01

One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group). A secondary aim was to assess the effects in kittens and pregnant animals. Buprenorphine 180 µg/m(2) or butorphanol 6 mg/m(2) were given with either carprofen 4 mg/kg (groups BUPC and BUTC, respectively) or meloxicam 0.3 mg/kg (groups BUPM or BUTM, respectively). Medetomidine was not antagonised. A simple, descriptive scale (SDS; 0-4), a dynamic and interactive visual analogue scale (DIVAS; 0-100 mm) and mechanical nociceptive thresholds (MT; 2.5-mm diameter probe) were used to evaluate postoperative pain. All pain scores were low (DIVAS 10 N) and there were no significant differences between the groups. It was concluded that all protocols provided adequate analgesia and when used with midazolam-medetomidine-ketamine are effective for routine feline ovariohysterectomy.

Postoperative analgesic effects of dexketoprofen, buprenorphine and tramadol in dogs undergoing ovariohysterectomy.

Science.gov (United States)

Morgaz, J; Navarrete, R; Muñoz-Rascón, P; Domínguez, J M; Fernández-Sarmiento, J A; Gómez-Villamandos, R J; Granados, M M

2013-08-01

The objective of this study was to compare the postoperative analgesic effects of dexketoprofen, tramadol, and buprenorphine in dogs undergoing ovariohysterectomy. Seventy-five adult female dogs were randomly assigned to receive an intravenous injection (IV) of 1mg/kg of dexketoprofen (D), 0.02 mg/kg of buprenorphine (B) or 2mg/kg of tramadol (T). Pain assessment was performed during 48 h after ovariohysterectomy using a dynamic interactive visual analogue scale (DIVAS) and Glasgow composite measure pain scale (CMPS-SF). Rescue analgesia was required in 43%, 21%, and 5% of dogs in the B, T, and D groups, respectively, with significant differences between B and D (p=0.010) groups. The DIVAS and CMPS-SF values of the B group were significantly higher than those of the T and D groups. The most common undesirable effect was dysphoria in dexketoprofen group. Tramadol and dexketoprofen provide superior postoperative analgesia compared with buprenorphine in dogs undergoing ovariohysterectomy. Copyright © 2013 Elsevier Ltd. All rights reserved.

Effect of gamma-irradiation on the fatty acid composition of salted, semi-dried Vietnamese scad and Bombay duck

International Nuclear Information System (INIS)

Vinh, P.Q.; Rao, V.S.; Adhikar, H.R.; Nair, P.M.

1994-01-01

Effect of gamma irradiation on the lipid and fatty acid composition of semi-dried Bombay duck (Harpodon nehcreus) and Vietnamese scad (Alepes mate) was studied. In both these dried fishes, c16:0 aand c18:1 were the predominant fatty acids and the fishes contained ignificant quantities of the n-3 polyunsaturated fatty acids (PUFAs), C20:5 and C22:6. Irradiation at a dose of 3 kGy, did not cause any alterations in the total lipid content and he overall lipid class profile in these fishes. However, in the Vietnamese scad, C18:3, C20:4 and C22:6 were significantly decreased in the irradiated samples. In spite of this decrease the irradiated semi-dried scad retained 82% of the initial amount of n-3 PUFAs

Dual function of the hemagglutinin H5 fused to chicken CD154 in a ...

African Journals Online (AJOL)

Dual function of the hemagglutinin H5 fused to chicken CD154 in a potential strategy of DIVA against avian influenza disease: preliminary study. AG Pose, ES Rodriguez, AC Mendez, JN Gomez, AV Redondo, ER Rodriguez, EMG Ramos, AA Gutierrez, MPR Molto, DG Roche, YS Ugalde, AM Lopez ...

Plaadid / Aleks Lange

Index Scriptorium Estoniae

Lange, Aleks

2003-01-01

Uutest plaatidest Ricky Martin "Almas del Silencio", Paul McCartney "Back In Th e World", The Ultimate "Diva Collection", Girls Aloud "Sound Of The Underground", Blacky "Kui me päikeseloojangut ootama peaks", Christoph Poppen, Münchner Kammerorchester, The Hilliard Ensemble, Cerys Matthews "Cockahoop", Radiohead "Hail to the Thief"

Safety and Efficacy Profile of Commercial Veterinary Vaccines against Rift Valley Fever: A Review Study

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Moataz Alhaj

2016-01-01

Full Text Available Rift Valley Fever (RVF is an infectious illness with serious clinical manifestations and health consequences in humans as well as a wide range of domestic ruminants. This review provides significant information about the prevention options of RVF along with the safety-efficacy profile of commercial vaccines and some of RVF vaccination strategies. Information presented in this paper was obtained through a systematic investigation of published data about RVF vaccines. Like other viral diseases, the prevention of RVF relies heavily on immunization of susceptible herds with safe and cost-effective vaccine that is able to confer long-term protective immunity. Several strains of RVF vaccines have been developed and are available in commercial production including Formalin-Inactivated vaccine, live attenuated Smithburn vaccine, and the most recent Clone13. Although Formalin-Inactivated vaccine and live attenuated Smithburn vaccine are immunogenic and widely used in prevention programs, they proved to be accompanied by significant concerns. Despite Clone13 vaccine being suggested as safe in pregnant ewes and as highly immunogenic along with its potential for differentiating infected from vaccinated animals (DIVA, a recent study raised concerns about the safety of the vaccine during the first trimester of gestation. Accordingly, RVF vaccines that are currently available in the market to a significant extent do not fulfill the requirements of safety, potency, and DIVA. These adverse effects stressed the need for developing new vaccines with an excellent safety profile to bridge the gap in safety and immunity. Bringing RVF vaccine candidates to local markets besides the absence of validated serological test for DIVA remain the major challenges of RVF control.

Biogeografía histórica de la familia Curculionidae (Coleoptera en las subregiones Subantártica y Chilena Central Historical biogeography of family Curculionidae (Coleoptera on Subantarctic and Central Chilean subregions

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Paula Posadas

2003-07-01

Full Text Available El análisis de los patrones de distribución y la información filogenética de 71 especies de Curculionidae, distribuidas en las subregiones Subantártica y Chilena Central, aplicando los métodos biogeográficos de los árboles reconciliados y análisis de parsimonia de Brooks (BPA, resulta en un único cladograma general de áreas: ((Chile Central (Maule, Bosque Valdiviano (Islas Malvinas (Páramo Magallánico, Bosque Magallánico. La aplicación del análisis de dispersión-vicarianza (DIVA muestra que el evento vicariante más frecuente es el que separa las Islas Malvinas de las otras dos provincias subantárticas meridionales. Por otra parte, de acuerdo con los resultados del DIVA, se evidencia que las relaciones entre el Maule, Bosque Valdiviano y Chile Central no se deberían a eventos de vicarianza sino a eventos de dispersión, ya que el 61% del total de los eventos de dispersión implica a estas tres áreas. Aún más, los eventos de dispersión más frecuentes implican al Maule, ya sea en relación con Chile Central o con el Bosque Valdiviano, por lo que se deduce que la aparente complejidad de las relaciones biogeográficas del Maule podría estar relacionada con dichos eventos de dispersión.The application of the historical biogeographic techniques of reconciled trees and Brooks parsimony analysis (BPA to the distributional and phylogenetic information of 71 species of Curculionidae ranged in the Subantarctic and Central Chilean subregions results in a single general area cladogram: ((Central Chile (Maule, Valdivian Forest (Malvinas Islands (Magellanic Moorland, Magellanic Forest. The application of dispersal-vicariance analysis (DIVA to the same data set shows as the most frequent vicariant event the split of Islas Malvinas from the two southern Subantarctic provinces. In addition, DIVA results evidenced that the relationship among Maule, Valdivian Forest, and Central Chile did not arise from vicariance events (common history

Speech Motor Programming in Apraxia of Speech: Evidence from a Delayed Picture-Word Interference Task

Science.gov (United States)

Mailend, Marja-Liisa; Maas, Edwin

2013-01-01

Purpose: Apraxia of speech (AOS) is considered a speech motor programming impairment, but the specific nature of the impairment remains a matter of debate. This study investigated 2 hypotheses about the underlying impairment in AOS framed within the Directions Into Velocities of Articulators (DIVA; Guenther, Ghosh, & Tourville, 2006) model: The…

Feedforward and Feedback Control in Apraxia of Speech: Effects of Noise Masking on Vowel Production

Science.gov (United States)

Maas, Edwin; Mailend, Marja-Liisa; Guenther, Frank H.

2015-01-01

Purpose: This study was designed to test two hypotheses about apraxia of speech (AOS) derived from the Directions Into Velocities of Articulators (DIVA) model (Guenther et al., 2006): the feedforward system deficit hypothesis and the feedback system deficit hypothesis. Method: The authors used noise masking to minimize auditory feedback during…

Promoting Resiliency in Adolescent Girls through Adventure Programming

Science.gov (United States)

Whittington, Anja; Aspelmeier, Jeffery E.; Budbill, Nadine W.

2016-01-01

This study examined whether participation in an adventure program increased the resiliency of adolescent girls. Eighty-seven girls who participated in Dirt Divas, a non-profit, adventure program, completed the Resiliency Scale for Children and Adolescents® before and after their experience. Means-comparison tests for within-subjects designs were…

Diagnósticos de enfermagem respiratórios para crianças com infecção respiratória aguda Diagnósticos de enfermería respiratorios para niños con infección respiratoria aguda Respiratory nursing diagnoses for children with acute respiratory infection

Directory of Open Access Journals (Sweden)

Lívia Zulmyra Cintra Andrade

2012-01-01

Full Text Available OBJETIVOS: Identificar a prevalência dos diagnósticos de enfermagem: Padrão respiratório ineficaz (PRI, Desobstrução ineficaz de vias aéreas (DIVA, Troca de gases prejudicada (TGP e Ventilação espontânea prejudicada (VEP suas características definidoras e fatores relacionados, em crianças com infecção respiratória aguda. MÉTODOS: Estudo de abordagem quantitativa, transversal, com 151 crianças. Os dados foram coletados por meio de entrevista e de avaliação pulmonar. Para análise dos dados, foi utilizada a estatística descritiva e inferencial. RESULTADOS: O diagnóstico mais prevalente foi PRI. Ruídos adventícios respiratórios e tosse ineficaz foram às características definidoras mais prevalentes. Ruídos adventícios respiratórios aumentam em 80% a chance para DIVA. Entre os fatores relacionados, destacaram-se: secreções nos brônquios e secreções retidas. Secreções nos brônquios favorecem em 80% a ocorrência de PRI e em 60% de DIVA. Verificou-se associação estatisticamente significante entre as características e fatores relacionados com os diagnósticos estudados. CONCLUSÃO: Os quatro diagnósticos foram identificados em crianças com infecções respiratórias agudas, apresentando prevalências distintas.OBJETIVOS: Identificar la prevalencia de los diagnósticos de enfermería: Patrón respiratorio ineficaz (PRI, Desobstrucción ineficaz de vías aéreas (DIVA, Intercambio de gases perjudicada (IGP y Ventilación espontánea perjudicada (VEP sus características definidoras y factores relacionados, en niños con infección respiratoria aguda. MÉTODOS: Estudio de abordaje cuantitativo, transversal, realizado con 151 niños. Los datos fueron recolectados por medio de entrevista y de evaluación pulmonar. Para el análisis de los datos, fue utilizada la estadística descriptiva e inferencial. RESULTADOS: El diagnóstico más prevalente fue el PRI. Los ruidos adventicios respiratorios y tos ineficaz fueron

Opisthobranchs from the Lesser Antilles

NARCIS (Netherlands)

Bois-Reymond Marcus, Eveline du; Marcus, Ernst

1963-01-01

Thanks to help of the Government of the Netherlands, Dr. DIVA DINIZ CORRÊA, a lecturer in our Department, was able to work at the “Caraïbisch Marien-Biologisch Instituut” (Caribbean Marine Biological Institute; Carmabi) Curaçao, from January to July 1962. Besides actinians and nemerteans for her own

The Secret Talents of Fundraisers

Science.gov (United States)

Pulley, John

2010-01-01

A significant but unknown number of performing artists have redirected their creativity and passion into development. They are ballet and contemporary dancers, jazz and orchestral musicians, actors and comedians, opera divas and gospel belters. None of them set out to become fundraisers. Yet here they are, and they partly credit their success in…

Aprovechamiento metabólico de granos de sorgo entero con diferentes contenidos de taninos en novillos británicos

Directory of Open Access Journals (Sweden)

A. E Fernández

Full Text Available Se evaluó la digestibilidad in vivo del almidón (DIVA del grano de sorgo entero, con altos y bajos contenidos de taninos (GSAT y GSBT, respectivamente, como suplemento, en machos bovinos en crecimiento; así como las pérdidas en heces y el efecto diferencial de estas pérdidas, según el contenido de taninos. Se establecieron dos tratamientos (T1 y T2 y dos repeticiones. Se empleó un diseño totalmente aleatorizado y cada animal constituyó una unidad experimental. Las dietas se suministraron una vez al día y estaban compuestas por diferentes proporciones de GSAT y GSBT, pellet de harina de girasol y heno de pastura mixta. El nivel proteínico fue de 18 y 15 % para el T1 y el T2, respectivamente. Se midió el consumo de MS (CMS, la digestibilidad in vivo de la MS (DIVMS, la DIVA y el consumo de agua por kilogramo de MS consumida. El CMS fue de 8,5 y 12,0 kg para el T1 y el T2, respectivamente, mientras que la DIVMS fue similar (71,64 y 71,66 %. La DIVA fue mayor en T1 (74,25 vs. 66,67 %; mientras que la pérdida de almidón en heces lo fue en T2 (31,56 vs. 27,27 %. El consumo de agua fue similar (1,8 L de agua/ kg de MS. Se concluye que hubo un comportamiento diferenciado en el aprovechamiento del grano de sorgo entero, debido al tamaño del animal y a los diferentes contenidos de taninos. Los terneros aprovecharon el 33 % de la oferta, y los novillos, el 25 %.

Multimeric recombinant M2e protein-based ELISA: a significant improvement in differentiating avian influenza infected chickens from vaccinated ones.

Directory of Open Access Journals (Sweden)

Farshid Hadifar

Full Text Available Killed avian influenza virus (AIV vaccines have been used to control H5N1 infections in countries where the virus is endemic. Distinguishing vaccinated from naturally infected birds (DIVA in such situations however, has become a major challenge. Recently, we introduced the recombinant ectodomain of the M2 protein (M2e of H5N1 subtype as a novel tool for an ELISA based DIVA test. Despite being antigenic in natural infection the monomer form of the M2e used in ELISA had limited antigenicity and consequently poor diagnostic capability. To address this shortcoming, we evaluated the use of four tandem copies of M2e (tM2e for increased efficiency of M2e antibody detection. The tM2e gene of H5N1 strain from Indonesia (A/Indonesia/CDC540/2006 was cloned into a pMAL- p4x expression vector and expressed in E.coli as a recombinant tM2e-MBP or M2e-MBP proteins. Both of these, M2e and tM2e antigens reacted with sera obtained from chickens following live H5N1 infection but not with sera from vaccinated birds. A significantly stronger M2e antibody reaction was observed with the tM2e compared to M2e antigen. Western blotting also supported the superiority of tM2e over M2e in detection of specific M2e antibodies against live H5N1 infection. Results from this study demonstrate that M2e tetramer is a better antigen than single M2e and could be more suitable for an ELISA based DIVA test.

Inferring ancestral distribution area and survival vegetation of Caragana (Fabaceae) in Tertiary

Science.gov (United States)

Mingli Zhang; Juanjuan Xue; Qiang Zhang; Stewart C. Sanderson

2015-01-01

Caragana, a leguminous genus mainly restricted to temperate Central and East Asia, occurs in arid, semiarid, and humid belts, and has forest, grassland, and desert ecotypes. Based on the previous molecular phylogenetic tree and dating, biogeographical analyses of extant species area and ecotype were conducted by means of four ancestral optimization approaches: S-DIVA,...

Author Details

African Journals Online (AJOL)

Ramos, EMG. Vol 5, No 2 (2015) - Articles Dual function of the hemagglutinin H5 fused to chicken CD154 in a potential strategy of DIVA against avian influenza disease: preliminary study. Abstract PDF. ISSN: 2218-6050. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

Polycladida from Curaçao and faunistically related regions

NARCIS (Netherlands)

Bois-Reymond Marcus, du Eveline; Marcus, Ernst

1968-01-01

Professor Dr. DIVA DINIZ CORRÊA, Head of the Department of Zoology of the University of São Paulo, was able to work at the “Caraïbisch Marien-Biologisch Instituut” (Caribbean Marine Biological Institute: Carmabi) at Curaçao from December 1965 to March 1966, thanks to a grant received from the

Storage properties of gamma-irradiated semi-dried fish varieties

International Nuclear Information System (INIS)

Vinh, P.Q.; Alur, M.D.; Nair, P.M.

1993-01-01

Several varieties of semi-dried unirradiated and irradiated (1 and 3 kGy) fish, namely, anchovies (Stolephorus commersonii), Bombay duck (Harpodon nehereus), shrimp (Penaeus indicus) and Vietnam scad (Alepes mate) were stored at ambient temperature (26 degree C). During the course of storage, quality characteristics such as total bacterial count (TBC), mould count and biochemical indices of freshness were studied. These studies indicated that initial TBC of semi-dried fish varied from 700-5400 cfu per g of fish, while mould could ranged from 27-1500 cfu per g. However, upon irradiation at 3 kGy, initial bacterial load was considerably reduced. Vietnam scad was not contaminated with mould after 3-5 months of storage at room temperature. Indices such as TVA and TVBN increased during storage at room temperature for both unirradiated and irradiated samples

Diva Carmen Luisa Letelier Valdés, contralto

Directory of Open Access Journals (Sweden)

Valene Georges

2012-06-01

Full Text Available Carmen Luisa Letelier Valdés y Valene Georges son fundadoras del célebre Ensemble Bartok Chile. En este trabajo Valene Georges presenta un recuerdo tanto de los titánicos logros que ambas han alcanzado con el Ensemble Bartok Chile en el país como en el extranjero, como de la estrecha amistad que las ha unido durante más de treinta años.Both Carmen Luisa Letelier-Valdés and Valene Georgesfounded the renowned Ensemble Bartok Chile. In this article Valene Georges presents a retrospective view ofthe titanic achievements that both have shared with this ensemble in Chile and abroad. Besides, the author presents a personal view ofher close friendship with Carmen Luisa during more than thirty years.

Dual function of the hemagglutinin H5 fused to chicken CD154 in a ...

African Journals Online (AJOL)

Dual function of the hemagglutinin H5 fused to chicken CD154 in a potential strategy of DIVA against avian influenza disease: preliminary study. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like ...

BIOCHEMICAL EFFECTS INDUCED BY UV TREATMENT ON 5 ROMANIAN PHASEOLUS VULGARIS L. CULTIVARS, GROWN IN FIELD

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Iulia Bara

2006-08-01

Full Text Available Our study is focused on the influence of the UV-B irradiation, at the level of hidric balance, methabolic activity, and in the content of minerals, polyphenols, pigments, nucleic acids, proteins, of five romanian cultivars: Diva, Star, Vera, Ami, Avans of Phaseolus vulgaris, sawn after germination in enreached UV-B environment in natural field condition.

Historical biogeographic analysis of the family Fanniidae (Díptera: Calyptratae, with special reference to the austral species of the genus Fannia (Diptera: Fanniidae using dispersal-vicariance analysis Análisis biogeográfico histórico de la familia Fanniidae (Diptera: Calyptratae, con referencia especial a las especies australes del genero Fannia (Diptera: Fanniidae usando análisis de dipersion-vicarianza

Directory of Open Access Journals (Sweden)

M. CECILIA DOMÍNGUEZ

2011-03-01

Full Text Available The purpose of this study was to achieve a hypothesis explaining the biogeographical history of the family Fanniidae, especially that of the species from Patagonia, the Neotropics, Australia, and New Zealand. We used "dispersal-vicariance analysis" (DIVA, an event-based parsimony method, to analyze the most parsimonious phylogenetic hypothesis for the family, obtained by Domínguez & Roig-Juñent (2008. The analysis resulted in 32800 alternative equally optimal reconstructions that indicate that the ancestor of the Fanniidae was widely distributed across different regions of the world, which along with the subsequent separation of two clades that correspond to the Laurasic and Gondwanan Landmasses allow the proposal of an older age than in previous hypothesis (Late Jurassic or early Cretaceous times instead of upper Cretaceous and a Pangeic origin for the Fanniidae. The northern hemisphere species of Fanniidae included in this study highlight the difficulty that arises when analysing with DIVA a tree with a large amount of paralogy or redundant distributions, as illustrated here with several examples. The southern hemisphere species of Fanniidae indicate a clear pattern of vicariance and dispersal consistent with the rupture of Gondwana.El propósito de este estudio fue el de obtener una hipótesis que explique la historia biogeográfica de la familia Fanniidae, especialmente la de las especies de las regiones Patagónica, Neotropical, Australiana y Neozelandesa. Se utilizó el método de "dispersión y vicarianza" (DIVA, el cual es un método de parsimonia basado en eventos para analizar el árbol filogenético más parsimonioso obtenido por Domínguez & Roig-Juñent (2008. El análisis resultó en 32800 reconstrucciones alternativas igualmente óptimas que indican que el ancestro de Fanniidae estaba ampliamente distribuido en distintas regiones del mundo, lo cual junto con la subsiguiente separación de dos clados que corresponderían a los

An economic model for energisation and its integration into the urban energy planning process

International Nuclear Information System (INIS)

Nissing, Christian; Blottnitz, Harro von

2010-01-01

It is widely recognised that access to and supply of modern energy play a key role in poverty alleviation and sustainable development. The emerging concept of energisation seems to capture this idea, and if implemented in its full complexity it should have multiple beneficial effects. To demonstrate this, an economic model is developed for an urban developmental context, drawing on the theory of urban ecosystems and illustrating energy and waste production and consumption issues with current South African data sets. This new understanding of the concept of energisation is then integrated into a local government energy planning process, by means of a checklist for energy planners, covering 18 aspects that between them affect all 7 identifiable tiers of the energy service supply network. A 6-step structured approach is proposed for integrating sustainable energisation into the first four phases of the advanced local energy planning (ALEP) tool.

New Mediterranean Biodiversity Records (July 2015

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K. TSIAMIS

2015-07-01

The new records of alien species include: the red algae Antithamnionella elegans and Palisada maris-rubri, found for the first time in Israel and Greece respectively; the green alga Codium parvulum reported from Turkey (Aegean Sea; the first record of the alien sea urchin Diadema setosum in Greece; the nudibranch Goniobranchus annulatus reported from South-Eastern Aegean Sea (Greece; the opisthobranch Melibe viridis found in Lebanon; the new records of the blue spotted cornetfish Fistularia commersonii in the Alicante coast (Eastern Spain; the alien fish Siganus luridus and Siganus rivulatus in Lipsi Island, Dodecanese (Greece; the first record of Stephanolepis diaspros from the Egadi Islands Marine Protected Area (western Sicily; a northward expansion of the alien pufferfish Torquigener flavimaculosus along the southeastern Aegean coasts of Turkey; and data on the occurrence of the Lessepsian immigrants Alepes djedaba, Lagocephalus sceleratus and Fistularia commersonii in Zakynthos Island (SE Ionian Sea, Greece.

Primeiro os amigos: os aniversários da infância, dar e receber Friends first: childhood birthdays, giving and receiving

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Régine Sirota

2005-08-01

Full Text Available Desde a infância, os aniversários propiciam trabalhos de socialização. Esse ritual, que costuma agrupar crianças da mesma faixa etária, faz surgir uma obrigação de trocar presentes: dádivas e contradádivas regem as seqüências da festa de aniversário. A abordagem etnográfica permite apreender o papel que cada ator social (filhos, pais, amigos desempenha na construção social desse ritual. Os presentes estão no cerne de um verdadeiro trabalho de negociações no qual se confrontam constantemente normas e valores.Ever since childhood birthday parties allow a process of socialization. Such ritual, which usually gathers children of a same age group, is an opportunity to exchange presents: gifts and counter-gifts structure the sequences of birthday parties. An ethnological approach thus enables to seize the contribution of each social actor (children, parents, relatives, and friends in the social constructions of this ritual. Presents are the object of a real negotiation implying a permanent confrontation of norms and values through which a social link is built.

Il Fuoco or the fatal portrait : the XIXth century in the Italian silent cinema

NARCIS (Netherlands)

Blom, I.L.

1992-01-01

Dans les années dix de notre siècle, un genre nouveau de film s'installe en Italie aux côtés des grandes productions historiques : le cinéma des divas dont l'histoire-type tourne autour des drames d'un "ménage à trois". Il Fuoco (Giovanni Pastrone, 1915) serait, selon l'auteur, un film moderne qui,

The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037

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Bruin Sjoerd C

2010-10-01

Full Text Available Abstract Background Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis. Methods/Design In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm. Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm. The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%. Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and power = 90% in favour of the patients with resection with primary anastomosis. Secondary endpoints for both arms are the number of days alive and outside the hospital, health related quality of life, health care utilisation and associated costs. Discussion The Ladies trial is a nationwide multicentre randomised trial on perforated diverticulitis that will provide evidence on the merits of laparoscopic lavage and drainage for purulent generalised peritonitis and on the optimal resectional strategy

Calculation of SAR and temperature rise in a high-resolution vascularized model of the human eye and orbit when exposed to a dipole antenna at 900, 1500 and 1800 MHz.

Science.gov (United States)

Flyckt, V M M; Raaymakers, B W; Kroeze, H; Lagendijk, J J W

2007-05-21

The eye is considered to be a critical organ when determining safety standards for radiofrequency radiation. With a detailed anatomy of the human eye and orbit inserted in a whole-head model, the specific absorption rates (SARs) and thermal effects were determined under exposure to a dipole antenna representing a mobile phone operating at 900, 1500 and 1800 MHz with an output power of 1 W. The temperature rise was calculated by taking the blood flow into account either by the Pennes bioheat model or by including the discrete vasculature (DIVA). In addition, a simple spherical model using constant heat transfer coefficients was used. Peak SARs in the humour are 4.5, 7.7 and 8.4 W kg(-1) for 900, 1500 and 1800 MHz respectively. Averaged over the whole eyeball, the SARs are 1.7, 2.5 and 2.2 W kg(-1). The maximum temperature rises in the eye due to the exposure are 0.22, 0.27 and 0.25 degrees C for exposure of 900, 1500 and 1800 MHz, respectively, calculated with DIVA. For the Pennes bioheat model, the temperature rises are slightly lower: 0.19, 0.24, 0.22 degrees C respectively. For the simple spherical model, the maximum temperature rises are 0.15, 0.22 and 0.20 degrees C. The peak temperature is located in the anterior part of the lens for 900 MHz and deeper in the eye for higher frequencies, and in the posterior part of the lens for 1500 MHz and close to the centre of the eyeball for 1800 MHz. For these RF safety applications, both DIVA and the Pennes bioheat model could be used to relate the SAR distributions to the resulting temperature distributions. Even though, for these artificial exposure conditions, the SAR values are not in compliance with safety guidelines, the maximum temperature rises in the eye are too small to give harmful effects. The temperature in the eye also remains below body core temperature.

Calculation of SAR and temperature rise in a high-resolution vascularized model of the human eye and orbit when exposed to a dipole antenna at 900, 1500 and 1800 MHz

International Nuclear Information System (INIS)

Flyckt, V M M; Raaymakers, B W; Kroeze, H; Lagendijk, J J W

2007-01-01

The eye is considered to be a critical organ when determining safety standards for radiofrequency radiation. With a detailed anatomy of the human eye and orbit inserted in a whole-head model, the specific absorption rates (SARs) and thermal effects were determined under exposure to a dipole antenna representing a mobile phone operating at 900, 1500 and 1800 MHz with an output power of 1 W. The temperature rise was calculated by taking the blood flow into account either by the Pennes bioheat model or by including the discrete vasculature (DIVA). In addition, a simple spherical model using constant heat transfer coefficients was used. Peak SARs in the humour are 4.5, 7.7 and 8.4 W kg -1 for 900, 1500 and 1800 MHz respectively. Averaged over the whole eyeball, the SARs are 1.7, 2.5 and 2.2 W kg -1 . The maximum temperature rises in the eye due to the exposure are 0.22, 0.27 and 0.25 deg. C for exposure of 900, 1500 and 1800 MHz, respectively, calculated with DIVA. For the Pennes bioheat model, the temperature rises are slightly lower: 0.19, 0.24, 0.22 deg. C respectively. For the simple spherical model, the maximum temperature rises are 0.15, 0.22 and 0.20 deg. C. The peak temperature is located in the anterior part of the lens for 900 MHz and deeper in the eye for higher frequencies, and in the posterior part of the lens for 1500 MHz and close to the centre of the eyeball for 1800 MHz. For these RF safety applications, both DIVA and the Pennes bioheat model could be used to relate the SAR distributions to the resulting temperature distributions. Even though, for these artificial exposure conditions, the SAR values are not in compliance with safety guidelines, the maximum temperature rises in the eye are too small to give harmful effects. The temperature in the eye also remains below body core temperature

Calculation of SAR and temperature rise in a high-resolution vascularized model of the human eye and orbit when exposed to a dipole antenna at 900, 1500 and 1800 MHz

Energy Technology Data Exchange (ETDEWEB)

Flyckt, V M M; Raaymakers, B W; Kroeze, H; Lagendijk, J J W [Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)

2007-05-21

The eye is considered to be a critical organ when determining safety standards for radiofrequency radiation. With a detailed anatomy of the human eye and orbit inserted in a whole-head model, the specific absorption rates (SARs) and thermal effects were determined under exposure to a dipole antenna representing a mobile phone operating at 900, 1500 and 1800 MHz with an output power of 1 W. The temperature rise was calculated by taking the blood flow into account either by the Pennes bioheat model or by including the discrete vasculature (DIVA). In addition, a simple spherical model using constant heat transfer coefficients was used. Peak SARs in the humour are 4.5, 7.7 and 8.4 W kg{sup -1} for 900, 1500 and 1800 MHz respectively. Averaged over the whole eyeball, the SARs are 1.7, 2.5 and 2.2 W kg{sup -1}. The maximum temperature rises in the eye due to the exposure are 0.22, 0.27 and 0.25 deg. C for exposure of 900, 1500 and 1800 MHz, respectively, calculated with DIVA. For the Pennes bioheat model, the temperature rises are slightly lower: 0.19, 0.24, 0.22 deg. C respectively. For the simple spherical model, the maximum temperature rises are 0.15, 0.22 and 0.20 deg. C. The peak temperature is located in the anterior part of the lens for 900 MHz and deeper in the eye for higher frequencies, and in the posterior part of the lens for 1500 MHz and close to the centre of the eyeball for 1800 MHz. For these RF safety applications, both DIVA and the Pennes bioheat model could be used to relate the SAR distributions to the resulting temperature distributions. Even though, for these artificial exposure conditions, the SAR values are not in compliance with safety guidelines, the maximum temperature rises in the eye are too small to give harmful effects. The temperature in the eye also remains below body core temperature.

Annual report of the Division of Thermonuclear Fusion Research and the Division of Large Tokamak Development for the period of April 1, 1977 to March 31, 1978

International Nuclear Information System (INIS)

1979-02-01

Research and development works in fiscal year 1977 of the Division of Thermonuclear Fusion Research and the Division of Large Tokamak Development are described. 1) Theoretical studies on tokamak confinement have continued with more emphasis on computations. A task was started of developing a computer code system for mhd behavior of tokamak plasmas. 2) Experimental studies of lower hybrid heating up to 140 kW were made in JFT-2. The ion temperature was increased by 50% -- 60% near the plasma center. Plasma-wall interactions (particle and thermal fluxes to the wall, and titanium gettering) were studied. In JFT-2a (DIVA) ion sputtering, arcing and evaporation were identified, and the impurity ion sputtering was found to be a dominant origin of metal impurities in the present tokamaks. High temperature and high-density plasma divertor actions were demonstrated; i.e. the divertor decreases the radiation power loss by a factor of 3 and increases the energy confinement time by a factor of 2.5. Various diagnostic instruments operated sufficiently to provide useful information for the research with JFT-2 and JFT-2a(DIVA). 3) JFT-2 and JFT-2a(DIVA) operated as scheduled. Technological improvements were made such as titanium coating of the chamber wall, discharge cleaning and pre-ionization. 4) Detailed design of the prototype JT-60 neutral beam injector was made. A 200 kW, 650 MHz radiofrequency heating system for JFT-2 was completed; a lower hybrid heating experiment in JFT-2 was successful 5) In particle-surface interactions, the sputtering and surface erosion were studied. 6) Improvement designs of a superconducting cluster test facility and a test module coil were made in the toroidal coil development. 7) Second preliminary design of the tokamak experimental fusion reactor JXFR started in April 1977. Safety analyses were made of the main components and system of JXFR on the basis of the first preliminary design. (J.P.N.)

Solving Ordinary Differential Equations

Science.gov (United States)

Krogh, F. T.

1987-01-01

Initial-value ordinary differential equation solution via variable order Adams method (SIVA/DIVA) package is collection of subroutines for solution of nonstiff ordinary differential equations. There are versions for single-precision and double-precision arithmetic. Requires fewer evaluations of derivatives than other variable-order Adams predictor/ corrector methods. Option for direct integration of second-order equations makes integration of trajectory problems significantly more efficient. Written in FORTRAN 77.

The Vocal Extent Measure: Development of a Novel Parameter in Voice Diagnostics and Initial Clinical Experience

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Philipp P. Caffier

2018-01-01

Full Text Available Voice range profile (VRP and evaluation using the dysphonia severity index (DSI represent essentials of instrument-based objective voice diagnostics and are implemented in different standardized registration programs. The respective measurement results, however, show differences. The aim of the study was to prove these differences statistically and to develop a new parameter, the Vocal Extent Measure (VEM, which is not influenced by the measurement program. VRPs of 97 subjects were recorded by two examiners using the established registration programs DiVAS (XION medical and LingWAVES (WEVOSYS simultaneously. The VEM was developed on the basis of VRP area and perimeter. All 194 VRP files were analyzed for various parameters and gender independence. The registration programs exhibited significant differences in several vocal parameters. A significant gender influence for DSI was found with DiVAS (p<0.01, but not with LingWAVES. The VEM quantified the dynamic performance and frequency range by a unidimensional, interval-scaled value without unit, mostly between 0 and 120. This novel parameter represents an intelligible and user-friendly positive measure of vocal function, allows simple and stable VRP description, and seems to be suitable for quantification of vocal capacity. In contrast to DSI, the VEM proved to be less susceptible to registration program and gender.

Acupuncture and pharmacopuncture are as effective as morphine or carprofen for postoperative analgesia in bitches undergoing ovariohysterectomy.

Science.gov (United States)

Luna, Stelio Pacca Loureiro; Martino, Irene Di; Lorena, Silvia Elaine Rodolfo de Sá; Capua, Maria Luisa Buffo de; Lima, Alfredo Feio da Maia; Santos, Bianca Paiva Costa Rodrigues dos; Brondani, Juliana Tabarelli; Vesce, Giancarlo

2015-12-01

To investigate the analgesic effect of acupuncture (AP) or micro-dose pharmacopuncture (PA), using carprofen or morphine, in bitches undergoing ovariohysterectomy (OHE). Thirty five dogs were randomly assigned to five groups after sedation with acepromazine IM: AP, 0.5 mg.kg(-1) of morphine subcutaneously (SC), 4 mg.kg(-1) of carprofen SC, and PA with 0.05 mg.kg(-1) of morphine or 0.4 mg.kg(-1) of carprofen. Anaesthesia was induced with propofol and maintained with isoflurane. Pain was assessed after OHE by a blind observer for 24h, by dynamic visual analogue scale (DIVAS), Glasgow (CMPS-SF), Melbourne (UMPS) and Colorado University pain scale (CSU). Animals reaching 33% of the UMPS score received rescue analgesia with morphine IM. Non parametric data were analysed by Kruskal-Wallis or Friedman tests where applicable, followed by Dunn's test. Parametric data were analysed by two way ANOVA, followed by Tukey test. There were no differences among groups in number of rescue analgesia. Except for the DIVAS score where animals treated with morphine had the lowest score compared with AP and carprofen, at 1h after surgery, there were no other differences among groups. Acupuncture or pharmacopuncture were equally effective as morphine or carprofen to control postoperative pain in bitches undergoing ovariohysterectomy.

Auditory-Motor Interactions in Pediatric Motor Speech Disorders: Neurocomputational Modeling of Disordered Development

Science.gov (United States)

Terband, H.; Maassen, B.; Guenther, F.H.; Brumberg, J.

2014-01-01

Background/Purpose Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between neurological deficits in auditory and motor processes using computational modeling with the DIVA model. Method In a series of computer simulations, we investigated the effect of a motor processing deficit alone (MPD), and the effect of a motor processing deficit in combination with an auditory processing deficit (MPD+APD) on the trajectory and endpoint of speech motor development in the DIVA model. Results Simulation results showed that a motor programming deficit predominantly leads to deterioration on the phonological level (phonemic mappings) when auditory self-monitoring is intact, and on the systemic level (systemic mapping) if auditory self-monitoring is impaired. Conclusions These findings suggest a close relation between quality of auditory self-monitoring and the involvement of phonological vs. motor processes in children with pediatric motor speech disorders. It is suggested that MPD+APD might be involved in typically apraxic speech output disorders and MPD in pediatric motor speech disorders that also have a phonological component. Possibilities to verify these hypotheses using empirical data collected from human subjects are discussed. PMID:24491630

Plaadid / Villu Päärt

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2003-01-01

Uutest plaatidest Sarah Connor "Unbelievable", Robbie Williams "Escapology", Stan Getz "The Definitive Stan Getz", Santana "Sunrise", Wallflowers "Red Letter Days", Robert Palmer "At His Very Best", INXS "Definitive", Hilary Hahn "Mendelssohn/Shostakovich", System Of A Down "Steal This Album!", Disturbed "Believe", "Divas Las Vegas", Yann Tiersen " C'Etait Ici", We Will Rock You " Original London Cast Recording", Busta Rhymes " It Ain't Safe No More", David Bowie "Best Of", Terence Trent D'Arby "Greatest Hits"

How deep can surface signals be traced in the critical zone? Merging biodiversity with biogeochemistry research in a central German Muschelkalk landscape

Directory of Open Access Journals (Sweden)

Kirsten eKüsel

2016-04-01

Full Text Available The Earth’s Critical Zone (CZ is a thin living layer connecting atmosphere and geosphere, including aquifers. Humans live in the CZ and benefit from the vital supporting services it provides. However, the CZ is increasingly impacted by human activities including land and resource use, pollution and climate change. Recent interest in uniting the many disciplines studying this complex domain has initiated an international network of research infrastructure platforms that allow access to the CZ in a range of geologic settings. In this paper a new such infrastructure platform associated with the Collaborative Research Center AquaDiva is described, that uniquely seeks to combine CZ research with detailed investigation of the functional biodiversity of the subsurface. Overall, AquaDiva aims to test hypotheses about how water connects surface conditions set by land cover and land management to the biota and biogeochemical functions in the subsurface. With long-term and continuous observations, hypotheses about how seasonal variations and extreme events at the surface impact subsurface processes, community structure and function, are tested. AquaDiva has established the Hainich Critical Zone Exploratory (CZE in central Germany in an alkaline geological setting of German Triassic Muschelkalk formations. The Hainich CZE includes specialized monitoring wells to access the vadose zone and two main groundwater complexes in limestone and marlstone parent materials along a ~6 km transect spanning forest, pasture and agricultural land uses. Initial results demonstrate fundamental differences in the biota and biogeochemistry of the two aquifer complexes that trace back to the land uses in their respective recharge areas. They also show the importance of antecedent conditions on the impact of precipitation events on responses in terms of groundwater dynamics, chemistry and ecology. Thus we find signals of surface land use and events can be detected in the

IAEA INTOR workshop report, group 11

International Nuclear Information System (INIS)

Takeda, Tatsuoki; Kurita, Gen-ichi; Matsuura, Toshihiko; Ninomiya, Hiromasa; Tsunematsu, Toshihide

1980-01-01

Data base assessments of INTOR are presented. Included are the theoretical beta -limits, experimental results of current disruption in DIVA, wide range of parameter study of plasma shaping, effect of conducting shell on positional and ballooning mode, and the method of disruption control. Good shell effect of the SS blanket is examined. Also shown is the possibility of the equilibrium control of minor radius expansion. Design of hybrid poloidal coil system with exterior coils has been carried out. (author)

Eesti Ekspressi singel 3. Eesti Ekspressi singel 4

Index Scriptorium Estoniae

2008-01-01

6. nov. ilmuva Eesti Ekspressi vahel on metal-bändi Metsatöll singel "Merehunt" lisalooga "Alle-aa". Metstöllu kontserdid: 11. nov. USAs Minneapolises festivalil Heathen Crusade Metalfest ja 21. nov. Tartu klubis Rock'n'Roll. 13. nov. ilmuva ajalehe vahel on ansambli HU? singel "Kuum (vulkaan, mis vahel puhkab)" lisalooga "Kosmos (Loop Piratesi remiks)". HU? kontserdid: 14. nov. Pärnus klubis Sugar, 21. nov. Tartus klubis Illusion ja 6. dets. Kuressaares klubis Diva

Nove interpretacije fluvialnih sedimentov na krasu = New interpretations of fluvial sediments from the Kras

Directory of Open Access Journals (Sweden)

Andrej Mihevc

2007-01-01

Full Text Available Important unroofed caves with fluvial sediments from Divaški kras, Matarsko podoljePodgorski kras are presented. Extend of the phenomena and relation to the existingand karst surface and geomorphological meaning of them are described. Sedimentsthem were analysed and dated with different methods. The largest age of the sedimentfound in the unroofed cave excavated in Črnotiče quarry. In the cave wall fossil remainsstygobiont Marifugia cavatica were covered by 3.2-4.1 Ma old fluvial sediments.

Scaling for scrape-off layer plasma in tokamak

International Nuclear Information System (INIS)

Shimomura, Yasuo; Maeda, Hikosuke; Kimura, Haruyuki; Azumi, Masashi; Odajima, Kazuo

1977-12-01

Scaling for a scrape-off layer plasma in a tokamak is obtained by using DIVA (JFT-2a). The scaling gives the average electron temperature, the width and the mean electron density of the scrape-off layer. The temperature at the edge will be high in a future large tokamak with a small energy-loss by charge-exchange and radiation. The scrape-off layer plasma can easily shield the impurity influx from the wall. The fuel, however, can easily penetrate into the main plasma. (auth.)

ASTEC application to in-vessel corium retention

International Nuclear Information System (INIS)

Tarabelli, D.; Ratel, G.; Pelisson, R.; Guillard, G.; Barnak, M.; Matejovic, P.

2009-01-01

This paper summarizes the work done in the SARNET European Network of Excellence on Severe Accidents (6th Framework Programme of the European Commission) on the capability of the ASTEC code to simulate in-vessel corium retention (IVR). This code, jointly developed by the French Institut de Radioprotection et de Surete Nucleaire (IRSN) and the German Gesellschaft fuer Anlagen und Reaktorsicherheit mbH (GRS) for simulation of severe accidents, is now considered as the European reference simulation tool. First, the DIVA module of ASTEC code is briefly introduced. This module treats the core degradation and corium thermal behaviour, when relocated in the reactor lower head. Former ASTEC V1.2 version assumed a predefined stratified molten pool configuration with a metallic layer on the top of the volumetrically heated oxide pool. In order to reflect the results of the MASCA project, improved models that enable modelling of more general corium pool configurations were implemented by the CEA (France) into the DIVA module of the ASTEC V1.3 code. In parallel, the CEA was working on ASTEC modelling of the external reactor vessel cooling (ERVC). The capability of the ASTEC CESAR circuit thermal-hydraulics to simulate the ERVC was tested. The conclusions were that the CESAR module is capable of simulating this system although some numerical and physical instabilities can occur. Developments were then made on the coupling between both DIVA and CESAR modules in close collaboration with IRSN. In specific conditions, code oscillations remain and an analysis was made to reduce the numerical part of these oscillations. A comparison of CESAR results of the SULTAN experiments (CEA) showed an agreement on the pressure differences. The ASTEC V1.2 code version was applied to IVR simulation for VVER-440/V213 reactors assuming defined corium mass, composition and decay heat. The external cooling of reactor wall was simulated by applying imposed coolant temperature and heat transfer

Annual report of the Fusion Research and Development Center for the period of April 1, 1979 to March 31, 1980

International Nuclear Information System (INIS)

1981-03-01

Research and development activities of the Fusion Research and Development Center (Division of Thermonuclear Fusion Research and Division of Large Tokamak Development) from April 1979 to March 1980 are described. In Plasma physics research two experiments both related to radio-frequency power injection into tokamak plasmas are to be noted. One is the demonstration of current drive by lower hybrid waves in JFT-2 and the other high efficiency ICRF heating at two-ion hybrid resonance in JFT-2a/DIVA. A multi-MW neutral beam injection system was installed and tested at JFT-2 with heating experiments expected to start shortly. JFT-2a/DIVA was shutdown to make space for the injector. A new ingredient in this area is the initiation of dee plasma experiments in Doublet III at San Diego, USA by JAERI team under US-Japan cooperation agreement. Progress was rapid achieving all experimental objective planned for this period. Construction of JT-60 is in progress as planned. A Mukoyama site where JT-60 and other new facilities will be located was procured in October 1979, which was followed by the construction starts of JT-60 buildings. The completion of JT-60 is expected in fall 1984. The progressive brief summaries are presented in following topics; development of neutral beam and radiofrequency heating system for JT-60, installation of the cluster testing facility with NbTi field coils, and design of tritium handling facility. (J.P.N.)

Himalayan origin and evolution of Myricaria (Tamaricaeae in the neogene.

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Ming-Li Zhang

Full Text Available BACKGROUND: Myricaria consists of about twelve-thirteen species and occurs in Eurasian North Temperate zone, most species in the Qinghai-Tibet Plateau (QTP and adjacent areas. METHODOLOGY/PRINCIPAL FINDINGS: Twelve species of Myricaria plus two other genera Tamarix and Reaumuria in Tamaricaceae, were sampled, and four markers, ITS, rps16, psbB-psbH, and trnL-trnF were sequenced. The relaxed Bayesian molecular clock BEAST method was used to perform phylogenetic analysis and molecular dating, and Diva, S-Diva, and maximum likelihood Lagrange were used to estimate the ancestral area. The results indicated that Myricaria could be divided into four phylogenetic clades, which correspond to four sections within the genus, of them two are newly described in this paper. The crown age of Myricaria was dated to early Miocene ca. 20 Ma, at the probable early uplifting time of the Himalayas. The Himalayas were also shown as the center of origin for Myricaria from the optimization of ancestral distribution. Migration and dispersal of Myricaria were indicated to have taken place along the Asian Mountains, including the Himalayas, Kunlun, Altun, Hendukosh, Tianshan, Altai, and Caucasus etc., westward to Europe, eastward to Central China, and northward to the Mongolian Plateau. CONCLUSIONS/SIGNIFICANCE: Myricaria spatiotemporal evolution presented here, especially the Himalayan origin at early Miocene ca. 20 Ma, and then migrated westward and eastward along the Asian mountains, offers a significant evolutionary case for QTP and Central Asian biogeography.

High speed cine film studies of plasma behaviour and plasma surface interactions in tokamaks

International Nuclear Information System (INIS)

Goodall, D.H.J.

1982-01-01

High speed cine photography is a useful diagnostic aid for studying plasma behaviour and plasma surface interactions. Several workers have filmed discharges in tokamaks including ASDEX, DITE, DIVA, ISX, JFT2, TFR and PLT. These films are discussed and examples given of the observed phenomena which include plasma limiter interactions, diverted discharges, disruptions, magnetic islands and moving glowing objects often known as 'UFOs'. Examples of plasma structures in ASDEX and DITE not previously published are also given. The paper also reports experiments in DITE to determine the origin of UFOs. (orig.)

RH diversity in Mali: Characterization of a new haplotype RHD*DIVa ...

African Journals Online (AJOL)

Background: Knowledge of RH variants in African populations is critical to improving transfusion safety in countries with populations of African ancestry and to providing valuable information and direction for future development of transfusion in Africa. The purpose of this report is to describe RH diversity in individuals from ...

Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections.

Science.gov (United States)

Yang, Zhenhua; Wu, Rui; Li, Robert W; Li, Ling; Xiong, Zhongliang; Zhao, Haizhong; Guo, Deyin; Pan, Zishu

2012-04-01

A trans-complemented chimeric CSF-JE virus replicon was constructed using an infectious cDNA clone of the CSF virus (CSFV) Alfort/187 strain. The CSFV E2 gene was deleted, and a fragment containing the region encoding a truncated envelope protein (tE, amino acid 292-402, domain III) of JE virus (JEV) was inserted into the resultant plasmid, pA187delE2, to generate the recombinant cDNA clone pA187delE2/JEV-tE. Porcine kidney 15 (PK15) cells that constitutively express the CSFV E2p7 proteins were then transfected with in vitro-transcribed RNA from pA187delE2/JEV-tE. As a result, the chimeric CSF-JE virus replicon particle (VRP), rv187delE2/JEV-tE, was rescued. In a mouse model, immunization with the chimeric CSF-JE VRP induced strong production of JEV-specific antibody and conferred protection against a lethal JEV challenge. Pigs immunized with CSF-JE VRP displayed strong anti-CSFV and anti-JEV antibody responses and protection against CSFV and JEV challenge infections. Our evidence suggests that E2-complemented CSF-JE VRP not only has potential as a live-attenuated non-transmissible vaccine candidate against CSF and JE but also serves as a potential DIVA (Differentiating Infected from Vaccinated Animals) vaccine for CSF in pigs. Together, our data suggest that the non-transmissible chimeric VRP expressing foreign antigenic proteins may represent a promising strategy for bivalent DIVA vaccine design. Copyright © 2012 Elsevier B.V. All rights reserved.

Vaccination with recombinant RNA replicon particles protects chickens from H5N1 highly pathogenic avian influenza virus.

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Stefan J Halbherr

Full Text Available Highly pathogenic avian influenza viruses (HPAIV of subtype H5N1 not only cause a devastating disease in domestic chickens and turkeys but also pose a continuous threat to public health. In some countries, H5N1 viruses continue to circulate and evolve into new clades and subclades. The rapid evolution of these viruses represents a problem for virus diagnosis and control. In this work, recombinant vesicular stomatitis virus (VSV vectors expressing HA of subtype H5 were generated. To comply with biosafety issues the G gene was deleted from the VSV genome. The resulting vaccine vector VSV*ΔG(HA was propagated on helper cells providing the VSV G protein in trans. Vaccination of chickens with a single intramuscular dose of 2×10⁸ infectious replicon particles without adjuvant conferred complete protection from lethal H5N1 infection. Subsequent application of the same vaccine strongly boosted the humoral immune response and completely prevented shedding of challenge virus and transmission to sentinel birds. The vaccine allowed serological differentiation of infected from vaccinated animals (DIVA by employing a commercially available ELISA. Immunized chickens produced antibodies with neutralizing activity against multiple H5 viruses representing clades 1, 2.2, 2.5, and low-pathogenic avian influenza viruses (classical clade. Studies using chimeric H1/H5 hemagglutinins showed that the neutralizing activity was predominantly directed against the globular head domain. In summary, these results suggest that VSV replicon particles are safe and potent DIVA vaccines that may help to control avian influenza viruses in domestic poultry.

Analysis of ASTEC code adaptability to severe accident simulation for CANDU type reactors

International Nuclear Information System (INIS)

Constantin, Marin; Rizoiu, Andrei

2008-01-01

In order to prepare the adaptation of the ASTEC code to CANDU NPP severe accident analysis two kinds of activities were performed: - analyses of the ASTEC modules from the point of view of models and options, followed by CANDU exploratory calculation for the appropriate modules/models; - preparing the specifications for ASTEC adaptation for CANDU NPP. The paper is structured in three parts: - a comparison of PWR and CANDU concepts (from the point of view of severe accident phenomena); - exploratory calculations with some ASTEC modules- SOPHAEROS, CPA, IODE, CESAR, DIVA - for CANDU type reactors specific problems; - development needs analysis - algorithms, methods, modules. (authors)

Uma pedagogia da exemplaridade: a dádiva cristã como gratuidade

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Eduardo Dullo

2011-01-01

Full Text Available Durante pesquisa de campo, observei diversas atitudes de 'ajuda'. O presente artigo é uma descrição dessas relações sob a ótica da interação de dois coletivos de agentes: os católicos que presidem o Centro Social Marista e os jovens atendidos por esse Centro. A partir das 'ajudas' e da decorrente alteração de status advinda da consideração de uma bem sucedida 'inclusão social', analiso a produção de indivíduos exemplares, de cuja pedagogia traço a face ritual. Tais indivíduos estabelecem com outros jovens uma relação de exemplaridade que, por sua vez, e fechando o circuito, é central para a concretização do sistema de trocas baseadas na gratuidade e para a tentativa de consolidação de uma comunidade moral de semelhantes.

Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection

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Pérez de Val Bernat

2012-10-01

Full Text Available Abstract Background Most countries carrying out campaigns of bovine tuberculosis (TB eradication impose a ban on the use of mycobacterial vaccines in cattle. However, vaccination against paratuberculosis (PTB in goats is often allowed even when its effect on TB diagnosis has not been fully evaluated. To address this issue, goat kids previously vaccinated against PTB were experimentally infected with TB. Results Evaluation of interferon-γ (IFN-γ secretion induced by avian and bovine tuberculins (PPD showed a predominant avian PPD-biased response in the vaccinated group from week 4 post-vaccination onward. Although 60% of the animals were bovine reactors at week 14, avian PPD-biased responses returned at week 16. After challenge with M. caprae, the IFN-γ responses radically changed to show predominant bovine PPD-biased responses from week 18 onward. In addition, cross-reactions with bovine PPD that had been observed in the vaccinated group at week 14 were reduced when using the M. tuberculosis complex-specific antigens ESAT-6/CFP-10 and Rv3615c as new DIVA (differentiation of infected and vaccinated animals reagents, which further maintained sensitivity post-challenge. Ninety percent of the animals reacted positively to the tuberculin cervical comparative intradermal test performed at 12 weeks post-infection. Furthermore, post-mortem analysis showed reductions in tuberculous lesions and bacterial burden in some vaccinated animals, particularly expressed in terms of the degree of extrapulmonary dissemination of TB infection. Conclusions Our results suggest a degree of interference of PTB vaccination with current TB diagnostics that can be fully mitigated when using new DIVA reagents. A partial protective effect associated with vaccination was also observed in some vaccinated animals.

Classical swine fever vaccines-State-of-the-art.

Science.gov (United States)

Blome, Sandra; Moß, Claudia; Reimann, Ilona; König, Patricia; Beer, Martin

2017-07-01

Due to its impact on animal health and pig industry, classical swine fever (CSF) is still one of the most important viral diseases of pigs. To control the disease, safe and highly efficacious live attenuated vaccines exist for decades. These vaccines have usually outstanding efficacy and safety but lack differentiability of infected from vaccinated animals (DIVA or marker strategy). In contrast, the first generation of E2 subunit marker vaccines shows constraints in efficacy, application, and production. To overcome these limitations, new generations of marker vaccines are developed. A wide range of approaches have been tried including recombinant vaccines, recombinant inactivated vaccines or subunit vaccines, vector vaccines, and DNA/RNA vaccines. During the last years, especially attenuated deletion vaccines or chimeric constructs have shown potential. At present, especially two new constructs have been intensively tested, the adenovirus-delivered, Semliki Forest virus replicon-vectored marker vaccine candidate "rAdV-SFV-E2" and the pestivirus chimera "CP7_E2alf". The later was recently licensed by the European Medicines Agency. Under field conditions, all marker vaccines have to be accompanied by a potent test system. Particularly this point shows still weaknesses and it is important to embed vaccination in a well-established vaccination strategy and a suitable diagnostic workflow. In summary, conventional vaccines are a standard in terms of efficacy. However, only vaccines with DIVA will allow improved eradication strategies e.g. also under emergency vaccination conditions in free regions. To answer this demand, new generations of marker vaccines have been developed and add now to the tool box of CSF control. Copyright © 2017 Elsevier B.V. All rights reserved.

Preliminary assessment of the potential for mangrove oyster cultivation in Piraquê-açu river estuary (Aracruz, ES

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Luciana Alvarenga

2006-01-01

Full Text Available At Piraquê-açu river estuary, Aracruz, ES, the technical viability of Crassostrea rhizophorae cultivation was determined through monthly measures in shell length and weight. Seeds of C. rhizophorae were put in cages and suspended in rafts. Increase in height and weight (flesh and dry of the oysters was measured. During ten months (July/98 to May/99, oyster shell reached an average of 37.6 mm in shell height and 3.0 g in flesh weight (the whole animal. High mortality rates were registered and could be related to the high salinity water and to high predation observed, especially by flatworms Stylochophana divae and snails Cymatium parthenopeum, as well as fouling organisms such as barnacles, Serpulidae polychaetes and seed of the same species.No estuário do Rio Piraquê-açu, município de Aracruz, ES, foi avaliada a viabilidade técnica da implantação do cultivo de ostras Crassostrea rhizophorae em lanternas suspensas numa balsa de cultivo, através da estimativa de crescimento e ganho de peso fresco e seco das ostras. Verificou-se que, durante os dez meses de cultivo (junho/98 a maio/99, as ostras atingiram, em média, 37,6 mm de altura e 3,0 g no peso total. Foi registrada uma alta taxa de mortalidade, que poderia ser atribuída aos altos valores de salinidade na água e também aos predadores observados como planárias Stylochoplana divae e gastrópodos Cymatium parthenopeum, além de incrustantes como cracas, poliquetos Serpulidae e principalmente sementes da própria ostra.

New challenges for vaccination to prevent chlamydial abortion in sheep.

Science.gov (United States)

Entrican, Gary; Wheelhouse, Nick; Wattegedera, Sean R; Longbottom, David

2012-05-01

Ovine enzootic abortion (OEA) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. OEA remains a common cause of infectious abortion in many sheep-rearing countries despite the existence of commercially available vaccines that protect against the disease. There are a number of confounding factors that influence the uptake and use of these vaccines, which includes an inability to discriminate between infected and vaccinated animals (DIVA) using conventional serological diagnostic techniques. This suggests that the immunity elicited by current vaccines is similar to that observed in convalescent, immune sheep that have experienced OEA. The existence of these vaccines provides an opportunity to understand how protection against OEA is elicited and also to understand why vaccines can occasionally appear to fail, as has been reported recently for OEA. Interferon-gamma (IFN-γ), the cytokine that classically defines Th1-type adaptive immunity, is a strong correlate of protection against OEA in sheep and has been shown to inhibit the growth of C. abortus in vitro. Humoral immunity to C. abortus is observed in both vaccinated and naturally infected sheep, but antibody responses tend to be used more as diagnostic markers than targets for strategic vaccine design. A future successful DIVA vaccine against OEA should aim to elicit the immunological correlate of protection (IFN-γ) concomitantly with an antibody profile that is distinct from that of the natural infection. Such an approach requires careful selection of protective components of C. abortus combined with an effective delivery system that elicits IFN-γ-producing CD4+ve memory T cells. Copyright © 2012 Elsevier Ltd. All rights reserved.

Integrated fossil and molecular data reveal the biogeographic diversification of the eastern Asian-eastern North American disjunct hickory genus (Carya Nutt.).

Science.gov (United States)

Zhang, Jing-Bo; Li, Rui-Qi; Xiang, Xiao-Guo; Manchester, Steven R; Lin, Li; Wang, Wei; Wen, Jun; Chen, Zhi-Duan

2013-01-01

The hickory genus (Carya) contains ca. 17 species distributed in subtropical and tropical regions of eastern Asia and subtropical to temperate regions of eastern North America. Previously, the phylogenetic relationships between eastern Asian and eastern North American species of Carya were not fully confirmed even with an extensive sampling, biogeographic and diversification patterns had thus never been investigated in a phylogenetic context. We sampled 17 species of Carya and 15 species representing all other genera of the Juglandaceae as outgroups, with eight nuclear and plastid loci to reconstruct the phylogeny of Carya. The phylogenetic positions of seven extinct genera of the Juglandaceae were inferred using morphological characters and the molecular phylogeny as a backbone constraint. Divergence times within Carya were estimated with relaxed Bayesian dating. Biogeographic analyses were performed in DIVA and LAGRANGE. Diversification rates were inferred by LASER and APE packages. Our results support two major clades within Carya, corresponding to the lineages of eastern Asia and eastern North America. The split between the two disjunct clades is estimated to be 21.58 (95% HPD 11.07-35.51) Ma. Genus-level DIVA and LAGRANGE analyses incorporating both extant and extinct genera of the Juglandaceae suggested that Carya originated in North America, and migrated to Eurasia during the early Tertiary via the North Atlantic land bridge. Fragmentation of the distribution caused by global cooling in the late Tertiary resulted in the current disjunction. The diversification rate of hickories in eastern North America appeared to be higher than that in eastern Asia, which is ascribed to greater ecological opportunities, key morphological innovations, and polyploidy.

Integrated fossil and molecular data reveal the biogeographic diversification of the eastern Asian-eastern North American disjunct hickory genus (Carya Nutt..

Directory of Open Access Journals (Sweden)

Jing-Bo Zhang

Full Text Available The hickory genus (Carya contains ca. 17 species distributed in subtropical and tropical regions of eastern Asia and subtropical to temperate regions of eastern North America. Previously, the phylogenetic relationships between eastern Asian and eastern North American species of Carya were not fully confirmed even with an extensive sampling, biogeographic and diversification patterns had thus never been investigated in a phylogenetic context. We sampled 17 species of Carya and 15 species representing all other genera of the Juglandaceae as outgroups, with eight nuclear and plastid loci to reconstruct the phylogeny of Carya. The phylogenetic positions of seven extinct genera of the Juglandaceae were inferred using morphological characters and the molecular phylogeny as a backbone constraint. Divergence times within Carya were estimated with relaxed Bayesian dating. Biogeographic analyses were performed in DIVA and LAGRANGE. Diversification rates were inferred by LASER and APE packages. Our results support two major clades within Carya, corresponding to the lineages of eastern Asia and eastern North America. The split between the two disjunct clades is estimated to be 21.58 (95% HPD 11.07-35.51 Ma. Genus-level DIVA and LAGRANGE analyses incorporating both extant and extinct genera of the Juglandaceae suggested that Carya originated in North America, and migrated to Eurasia during the early Tertiary via the North Atlantic land bridge. Fragmentation of the distribution caused by global cooling in the late Tertiary resulted in the current disjunction. The diversification rate of hickories in eastern North America appeared to be higher than that in eastern Asia, which is ascribed to greater ecological opportunities, key morphological innovations, and polyploidy.

Equipment monitoring and diagnosis of their mechanical condition

International Nuclear Information System (INIS)

Morel, J.; Monnier, B.

1994-01-01

The main objectives of reactor monitoring are reviewed and the three monitoring types are described: reception controls and alarms, periodical controls, and specific monitoring. The monitoring process is then presented: information acquisition, dysfunction detection and diagnosis, risk analysis and maintenance action determination. Diagnosis assistance is now automated with expert systems such as DIVA (shaft vibration diagnosis) and DIAPO (primary pump diagnosis). Several application examples at EDF are described: SEXTEN reactor containment tightness monitoring, large and small-size turbo-machine monitoring, reactor inner structure monitoring, loose part detection in the primary circuit. All these informations will be centralized in a general monitoring and diagnosis assistance station. 3 fig

Artificial intelligence methods for diagnostic

International Nuclear Information System (INIS)

Dourgnon-Hanoune, A.; Porcheron, M.; Ricard, B.

1996-01-01

To assist in diagnosis of its nuclear power plants, the Research and Development Division of Electricite de France has been developing skills in Artificial Intelligence for about a decade. Different diagnostic expert systems have been designed. Among them, SILEX for control rods cabinet troubleshooting, DIVA for turbine generator diagnosis, DIAPO for reactor coolant pump diagnosis. This know how in expert knowledge modeling and acquisition is direct result of experience gained during developments and of a more general reflection on knowledge based system development. We have been able to reuse this results for other developments such as a guide for auxiliary rotating machines diagnosis. (authors)

Twitter.com kā korporatīvo sabiedrisko attiecību instruments Latvijā: satura analīze

OpenAIRE

Lulle, Katrīna

2010-01-01

Bakalaura darba tēma ir „Twitter.com kā korporatīvo sabiedrisko attiecību instruments Latvijā: satura analīze”. Darba ietvaros analizēti 10 Latvijas uzľēmumu Twitter.com profilu ieraksti laika periodā no 2009. gada decembra līdz 2010. gada februārim, kopumā 2780 ieraksti. Darba mērķis ir veikt Latvijas uzľēmumu Twitter.com profilu satura analīzi, lai noteiktu, kā Twitter.com tiek izmantots kā korporatīvo sabiedrisko attiecību instruments. Darbā ir divas teorētiskās nodaļas par sabied...

MHD equilibrium identification on ASDEX-Upgrade

International Nuclear Information System (INIS)

McCarthy, P.J.; Schneider, W.; Lakner, K.; Zehrfeld, H.P.; Buechl, K.; Gernhardt, J.; Gruber, O.; Kallenbach, A.; Lieder, G.; Wunderlich, R.

1992-01-01

A central activity accompanying the ASDEX-Upgrade experiment is the analysis of MHD equilibria. There are two different numerical methods available, both using magnetic measurements which reflect equilibrium states of the plasma. The first method proceeds via a function parameterization (FP) technique, which uses in-vessel magnetic measurements to calculate up to 66 equilibrium parameters. The second method applies an interpretative equilibrium code (DIVA) for a best fit to a different set of magnetic measurements. Cross-checks with the measured particle influxes from the inner heat shield and the divertor region and with visible camera images of the scrape-off layer are made. (author) 3 refs., 3 figs

Produtos sanguíneos lábeis

OpenAIRE

Amaral, Soraia Necho

2012-01-01

O Instituto Português do Sangue (IPS) é o único organismo competente e responsável pela gestão da medicina transfusional a nível nacional. As suas funções compreendem: a coordenação de todas as atividades relacionadas com a transfusão de sangue, desde a colheita da dádiva à administração do componente sanguíneo; o planeamento do Sistema Nacional de Hemovigilância, certificando-se da segurança dos componentes sanguíneos disponíveis e distribuídos; e a garantia da continuidade dos seus serviços...

Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR.

Science.gov (United States)

Nishiyama, Shoko; Slack, Olga A L; Lokugamage, Nandadeva; Hill, Terence E; Juelich, Terry L; Zhang, Lihong; Smith, Jennifer K; Perez, David; Gong, Bin; Freiberg, Alexander N; Ikegami, Tetsuro

2016-11-16

Rift Valley fever is a mosquito-borne zoonotic disease affecting ruminants and humans. Rift Valley fever virus (RVFV: family Bunyaviridae, genus Phlebovirus) causes abortions and fetal malformations in ruminants, and hemorrhagic fever, encephalitis, or retinitis in humans. The live-attenuated MP-12 vaccine is conditionally licensed for veterinary use in the US. However, this vaccine lacks a marker for the differentiation of vaccinated from infected animals (DIVA). NSs gene is dispensable for RVFV replication, and thus, rMP-12 strains lacking NSs gene is applicable to monitor vaccinated animals. However, the immunogenicity of MP-12 lacking NSs was not as high as parental MP-12. Thus, chimeric MP-12 strains encoding NSs from either Toscana virus (TOSV), sandfly fever Sicilian virus (SFSV) or Punta Toro virus Adames strain (PTA) were characterized previously. Although chimeric MP-12 strains are highly immunogenic, the attenuation through the S-segment remains unknown. Using pathogenic ZH501 strain, we aimed to demonstrate the attenuation of ZH501 strain through chimeric S-segment encoding either the NSs of TOSV, SFSV, PTA, or Punta Toro virus Balliet strain (PTB). In addition, we characterized rZH501 encoding a human dominant-negative PKR (PKRΔE7), which also enhances the immunogenicity of MP-12. Study done on mice revealed that attenuation of rZH501 occurred through the S-segment encoding either PKRΔE7 or SFSV NSs. However, rZH501 encoding either TOSV, PTA, or PTB NSs in the S-segment uniformly caused lethal encephalitis. Our results indicated that the S-segments encoding PKRΔE7 or SFSV NSs are attenuated and thus applicable toward next generation MP-12 vaccine candidates that encode a DIVA marker.

Auditory-motor interactions in pediatric motor speech disorders: neurocomputational modeling of disordered development.

Science.gov (United States)

Terband, H; Maassen, B; Guenther, F H; Brumberg, J

2014-01-01

Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between neurological deficits in auditory and motor processes using computational modeling with the DIVA model. In a series of computer simulations, we investigated the effect of a motor processing deficit alone (MPD), and the effect of a motor processing deficit in combination with an auditory processing deficit (MPD+APD) on the trajectory and endpoint of speech motor development in the DIVA model. Simulation results showed that a motor programming deficit predominantly leads to deterioration on the phonological level (phonemic mappings) when auditory self-monitoring is intact, and on the systemic level (systemic mapping) if auditory self-monitoring is impaired. These findings suggest a close relation between quality of auditory self-monitoring and the involvement of phonological vs. motor processes in children with pediatric motor speech disorders. It is suggested that MPD+APD might be involved in typically apraxic speech output disorders and MPD in pediatric motor speech disorders that also have a phonological component. Possibilities to verify these hypotheses using empirical data collected from human subjects are discussed. The reader will be able to: (1) identify the difficulties in studying disordered speech motor development; (2) describe the differences in speech motor characteristics between SSD and subtype CAS; (3) describe the different types of learning that occur in the sensory-motor system during babbling and early speech acquisition; (4) identify the neural control subsystems involved in speech production; (5) describe the potential role of auditory self-monitoring in developmental speech disorders. Copyright © 2014 Elsevier Inc. All rights reserved.

Annual report of Division of Thermonuclear Fusion Research and Division of Large Tokamak Development for the period of April 1, 1976 to March 31, 1977

International Nuclear Information System (INIS)

1978-02-01

Research and development activities in the two divisions are closely related. 1) Theoretical and computational studies continued on tokamak confinement and heating related to experimental problems. Studies on NBI heating in JT-60 were completed. 2) Experimental studies on impurities, density control and effects of density fluctuations were made in JFT-2. Neutral beams up to 30 keV and 8 A were injected into JFT-2 plasma perpendicularly. The ion temperature was increased by 10% - 15%, which is in agreement with the prediction by classical Fokker-Planck theory. In JFT-2a(DIVA), plasma-wall interaction (behavior of heavy and light impurities) was studies. The divertor of DIVA reduced the plasma-wall interaction and hence the radiation loss due to heavy impurities by a factor of 3. A grazing-incidence vacuum monochromator was first used in impurity studies in JFT-2 and JFT-2a. 3) Technological improvements were made raising efficiencies of operation, maintenance and plasma research. 4) Neutral beam injector test stand ITS-2 of 100 keV was completed. Construction of a 200 kW, 650 MHz radiofrequency heating system for JFT-2 was started. 5) Sputterings of molybdenum and pyrolytic graphite by low-energy protons and chemical reaction rates of pyrolytic graphite with protons were measured. Honeycomb structure greatly reduced the sputtered particles. 6) The superconducting magnet development group made the design of cluster test apparatus and the development of large current superconductor. 7) Phase-I preliminary design of experimental fusion reactor JXFR was completed and preliminary safety evaluation of JXFR was made. 8) Detailed design of JT-60 was completed in November 1976. Engineering development contracts were all completed by March 1977. 9) Engineering studies and tests on critical components of JT-4 with non-circular plasma cross section and divertors were made, after the preliminary design in fiscal year 1975. (auth.)

Tests of the Daimler D-IVa Engine at a High Altitude Test Bench

Science.gov (United States)

Noack, W G

1920-01-01

Reports of tests of a Daimler IVa engine at the test-bench at Friedrichshafen, show that the decrease of power of that engine, at high altitudes, was established, and that the manner of its working when air is supplied at a certain pressure was explained. These tests were preparatory to the installation of compressors in giant aircraft for the purpose of maintaining constant power at high altitudes.

Distribution and diversity of twelve Curcuma species in China.

Science.gov (United States)

Zhang, Lanyue; Wei, Jingwen; Yang, Zhiwen; Chen, Feng; Xian, Qiqiu; Su, Ping; Pan, Wanyi; Zhang, Kun; Zheng, Xi; Du, Zhiyun

2018-02-01

Genus Curcuma a wild species presents an important source of valuable characters for improving the cultivated Curcuma varieties. Based on the collected germplasms, herbariums, field surveys and other literatures, the ecogeographical diversity of Genus Curcuma and its potential distributions under the present and future climate are analysed by DIVA-GIS. The results indicate Genus Curcuma is distributed over 17 provinces in China, and particularly abundant in Guangxi and Guangdong provinces. The simulated current distributions are close to the actual distribution regions. In the future climate, the suitable areas for four Curcuma species will be extended, while for other three species the regions will be significantly decreased, and thus these valuable resources need protecting.

Molecular phylogenetics and historical biogeography of Rhinolophus bats.

Science.gov (United States)

Stoffberg, Samantha; Jacobs, David S; Mackie, Iain J; Matthee, Conrad A

2010-01-01

The phylogenetic relationships within the horseshoe bats (genus Rhinolophus) are poorly resolved, particularly at deeper levels within the tree. We present a better-resolved phylogenetic hypothesis for 30 rhinolophid species based on parsimony and Bayesian analyses of the mitochondrial cytochrome b gene and three nuclear introns (TG, THY and PRKC1). Strong support was found for the existence of two geographic clades within the monophyletic Rhinolophidae: an African group and an Oriental assemblage. The relaxed Bayesian clock method indicated that the two rhinolophid clades diverged approximately 35 million years ago and results from Dispersal Vicariance (DIVA) analysis suggest that the horseshoe bats arose in Asia and subsequently dispersed into Europe and Africa.

"Divina": consagración cultural y usos de lo sagrado en la actriz mexicana María Félix (1914-2002

Directory of Open Access Journals (Sweden)

Carolina Benavente Morales

2010-01-01

Full Text Available Este estudio gira en torno a la noción de consagración cultural de Pierre Bourdieu enfocado a la actriz mexicana María Félix. Por un lado, se le aborda como una diva consagrada por las clases medias en ascenso en el contexto de la "época dorada" del cine mexicano, y, por el otro, como una mujer que agencia su propia consagración mediante una performance de vedette. Al vincular la persona a dinámicas y sectores sociales concretos, se observa la existencia de múltiples y divergentes libretos sobre la historia del siglo XX mexicano, y se intenta situar en relación con ellos la performance de la actriz.

Bagātīgo interneta lietojumprogrammu izstrādes platformu salīdzinājums

OpenAIRE

Degiļeviča, Karīna

2012-01-01

Maģistra darbā ir aprakstītas populārākas bagātīgo interneta lietojumprogrammu tehnoloģijas, tādas kā Ajax, JavaFX, Silverlight, Adobe Flex un HTML5. Autore detalizētāk apskatīja Adobe Flex un JavaFX tehnoloģijas, to iespējas un izstrādes ietvarus. Balstoties uz iegūto informāciju, autore izveidoja praktisko darbu, kur, izmantojot Adobe Flex un JavaFX platformas, realizētas divas tīmekļa lietojumprogrammatūras. Maģistrā darba ietvaros ir aprakstītas tehnoloģiju priekšrocības un trūkumi, ka ar...

Avec Lipse dans la tourmente : Louis du Gardin traducteur de la Diva Virgo Hallensis

NARCIS (Netherlands)

Meerhoff, K.

2017-01-01

The acts and writings of Louis du Gardin (1572-1633), town physician of Douay and professor of medicine at its Catholic University founded in 1560 by King Philip II of Spain, are considered in the context of what is called nowadays the process of “confessionalisation”. Like Saint-Omer, Lille,

In the Shadows of a Diva: Committing Homosexuality in David Henry Hwang's "M. Butterfly."

Science.gov (United States)

Eng, David L.

1994-01-01

Discusses racism, sexism, and sexual orientation through an analysis of the play "M. Butterfly." Focusing on the French diplomat, Gallimard, the essay discusses sexual orientation, explores Gallimard's racist investments in his orientalized vision of Song, and discusses his attempt to explain his love affair as heterosexual love gone…

MicroRNA expression profiling of PPD-B stimulated PBMC from M. bovis-challenged unvaccinated and BCG vaccinated cattle.

Science.gov (United States)

Golby, P; Villarreal-Ramos, B; Dean, G; Jones, G J; Vordermeier, M

2014-10-07

There is an urgent need to identify additional diagnostic biomarkers for bovine TB to complement existing read-out systems such as interferon-gamma and for predictive markers of vaccine efficacy to accelerate vaccine development. To evaluate the potential of miRNAs as such biomarkers, we have analysed their expression in bovine PPD stimulated PBMC isolated from unvaccinated and BCG vaccinated cattle before and following Mycobacterium bovis (M. bovis) infection. Using a bovine microRNA microarray, miR-155 was found to show a significant up-regulation in expression in early (week 2) and late (week 11) M. bovis post-infection samples from unvaccinated cattle, while in BCG vaccinated cattle up-regulation was observed only in late post-infection samples. No differential expression of miR-155 was observed in pre-infection samples from unvaccinated and vaccinated cattle. These observations suggest that miR-155 could be exploited as a marker distinguishing vaccinated from infected animals (DIVA). Analysis by TaqMan RT-PCR, verified the up-regulation of miR-155 in unvaccinated cattle post-infection. Significant correlation was found between the degree of pathology and miR-155 induction in the experimentally infected cattle, suggesting miR-155 is a biomarker of disease development and/or severity. Induction of miR155 expression in cattle sourced from farms with confirmed bTB that tested positive in the tuberculin skin or interferon-gamma blood test was found to be significantly higher in cattle presenting with more advanced pathology (defined by the presence of visible TB lesions) compared to infected cattle without visible pathology and thus likely to be of lower infectivity than those with more advanced disease. In conclusion, our data indicate that miR-155 has potential both as a diagnostic and prognostic biomarker that could be used to identify animals with advanced pathology and as a DIVA test read-out. Its role in the immune biology of bovine TB will also be discussed

Bluetongue Disabled Infectious Single Animal (DISA) vaccine: Studies on the optimal route and dose in sheep.

Science.gov (United States)

van Rijn, Piet A; Daus, Franz J; Maris-Veldhuis, Mieke A; Feenstra, Femke; van Gennip, René G P

2017-01-05

Bluetongue (BT) is a disease of ruminants caused by bluetongue virus (BTV) transmitted by biting midges of the Culicoides genus. Outbreaks have been controlled successfully by vaccination, however, currently available BT vaccines have several shortcomings. Recently, we have developed BT Disabled Infectious Single Animal (DISA) vaccines based on live-attenuated BTV without expression of dispensable non-structural NS3/NS3a protein. DISA vaccines are non-pathogenic replicating vaccines, do not cause viremia, enable DIVA and are highly protective. NS3/NS3a protein is involved in virus release, cytopathogenic effect and suppression of Interferon-I induction, suggesting that the vaccination route can be of importance. A standardized dose of DISA vaccine for serotype 8 has successfully been tested by subcutaneous vaccination. We show that 10 and 100times dilutions of this previously tested dose did not reduce the VP7 humoral response. Further, the vaccination route of DISA vaccine strongly determined the induction of VP7 directed antibodies (Abs). Intravenous vaccination induced high and prolonged humoral response but is not practical in field situations. VP7 seroconversion was stronger by intramuscular vaccination than by subcutaneous vaccination. For both vaccination routes and for two different DISA vaccine backbones, IgM Abs were rapidly induced but declined after 14days post vaccination (dpv), whereas the IgG response was slower. Interestingly, intramuscular vaccination resulted in an initial peak followed by a decline up to 21dpv and then increased again. This second increase is a steady and continuous increase of IgG Abs. These results indicate that intramuscular vaccination is the optimal route. The protective dose of DISA vaccine has not been determined yet, but it is expected to be significantly lower than of currently used BT vaccines. Therefore, in addition to the advantages of improved safety and DIVA compatibility, the novel DISA vaccines will be cost

Ação coletiva no âmbito da economia solidária e da autogestão Collective action in the realm of solidarity economics and self-management

Directory of Open Access Journals (Sweden)

Maria Eugênia Monteiro Castanheira

2008-06-01

Full Text Available Este ensaio traz reflexões sobre as motivações que conduzem a ação coletiva no âmbito da economia solidária e da autogestão, partindo do pressuposto de que, nestas esferas, a ação coletiva se diferencia daquela que se desenvolve nos domínios do capitalismo e daquela que se desenvolve no contexto social das relações tradicionais. Neste sentido, o objetivo deste ensaio é explorar as especificidades teóricas da ação coletiva orientada pelos princípios da economia solidária e da autogestão, tendo como enfoque analítico a teoria da dádiva. Para tanto, procurou-se, de forma articulada e seqüencial, problematizar a economia solidária, evidenciar os elementos constitutivos da autogestão e o aporte teórico da teoria da dádiva. Acredita-se que tais ponderações indicam um campo a ser explorado empiricamente, podendo contribuir para a elaboração de novos estudos e pesquisas sobre este tema.This essay reflects on the motivations that lead to collective action in the realm of solidarity economics and self-management, based on the presumption that, in these spheres, collective action is different from that which takes places in the domains of capitalism and that which develops in the social context of traditional relations. In this sense, the purpose of this essay is to explore the theoretical specificities of collective action guided by the principles of solidarity economics and self-management, with an analytical focus on the theory of donation. To do so, it sought to analyze solidarity economics in an articulated and sequential manner, to reveal the constituent elements of self management and the theoretical support for the theory of donation. These considerations indicate that there is much empirical research to do in this field, and such research can contribute to the elaboration of new studies and research about this issue.

Annual report of the fusion research and development center for the period of April 1, 1978 to March 31, 1979

International Nuclear Information System (INIS)

1980-03-01

Research and development activities of the Center are described. (1) Theoretical studies continued on tokamak confinement with more emphasis on computations. (2) In JFT-2, efforts were concentrated on the study of LH heating physics. Installation of remodeled JFT-2 was started in December 1978. In JFT-2a/DIVA, confinement scaling, ICRF heating were studied after reducing the impurity content with poloidal divertor or titanium coated surface. (3) JFT-2, JFT-2a/DIVA and motor-generator operated as planned. Improvements were made on Taylor type discharge cleaning and preionization. (4) In the development of a neutral beam system, hydrogen beam of 70 keV, 5.5 A, 0.1 sec duration was extracted from a two-stage ion source of diameter 10 cm. In JFT-2 LH heating, the transmitted RF power density was raised up to 1.2 kw/cm 2 by means of a new waveguide coupler of stainless steel whose inner surface was plated with copper and gettered with titanium. (5) In particle-surface interaction research, a special scanning electron microscope was developed to observe sample surfaces under ion bombardment. (6) In superconducting magnets development, detailed design of Japanese coil for Large Coil Task, and winding test of Japanese LCT conductor. (7) In the process technology of fuel recirculation and tritium production, thermal diffusion experiment using H 2 -He system and permeation test of H 2 and D 2 gas with Pd-Ag alloy membrane were made. (8) A second preliminary design of the experimental tokamak fusion reactor was started in April 1977, and finished in March 1979, with emphasis on realistic and credible solutions of the design problems. (9) On JT-60 construction of the tokamak machine was started in April 1978. The poloidal field power supply was also ordered in early 1979. Design study of the diagnostic equipment continued. Design of experimental and control buildings was completed, and design of the power supply building continued. (J.P.N.)

A goat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lasting neutralization antibody to high levels in goats and sheep.

Science.gov (United States)

Chen, Weiye; Hu, Sen; Qu, Linmao; Hu, Qianqian; Zhang, Qian; Zhi, Haibing; Huang, Kehe; Bu, Zhigao

2010-07-05

Recombinant capripoxvirus (CPV) is a promising candidate differentiating infected from vaccinated animals (DIVA) vaccine against peste-des-petits-ruminants (PPR). In order for recombinant CPV to be successfully used in the field, there should exist dependable indicators for quality control of vaccine products, surveillance and vaccination evaluation. Viral neutralization antibody (VNA) is correlated to protection against PPR and is a technically feasible indicator for this purpose. The immunogenicity of this vectored vaccine in goats and sheep, however, has not been fully evaluated. In this study, we generated two recombinant CPV viruses, rCPV-PPRVH and rCPV-PPRVF, that express PPR virus (PPRV) glycoproteins H and F, respectively. Vaccination studies with different dosages of recombinant viruses showed that rCPV-PPRVH was a more potent inducer of PPRV VNA than rCPV-PPRVF. One dose of rCPV-PPRVH was enough to seroconvert 80% of immunized sheep. A second dose induced significantly higher PPRV VNA titers. There was no significant difference in PPRV VNA responses between goats and sheep. Subcutaneous inoculation also induced a significant PPRV VNA response. PPRV VNA could be detected for over 6 months in more than 80% of vaccinated goats and sheep. Boost vaccination at 6-month intervals induced significant re-boost efficacy of PPRV VNA in goats and sheep. More over, two doses of rCPV-PPRVH could completely overcome the interference caused by pre-existing immunity to the CPV vaccine backbone in animals. Vaccination with rCPV-PPRVH also protected goats from virulent CPV challenge. Our results demonstrate that VNA can serve as a dependent indicator for effective vaccination and immune protection of animals in the field. The recombinant CPV vaccine used in our studies could be a practical and useful candidate DIVA vaccine in countries where PPR newly emerges or where stamp-out plans are yet to be implemented. Copyright 2010 Elsevier Ltd. All rights reserved.

Reliģijas makdonaldizācija

OpenAIRE

Siliņš, Toms

2012-01-01

Bakalaura darbā apskatītas makdonaldizācijas procesa izpausmes Latvijas reliģisko organizāciju darbībā. Pētījuma mērķis ir noskaidrot makdonaldizācijas izpausmes Latvijas reliģiskajās organizācijās, tādēļ izvirzīti pētījuma jautājumi – kādas ir liecības par makdonaldizācijas procesa ietekmi uz reliģiskajām organizācijām Latvijā un kā vērtējama makdonaldizācijas procesa ietekme uz reliģiskajām organizācijām Latvijā. Pētījuma ietvaros veiktas divas ekspertu intervijas, kuru analīzes rezultātā i...

Prokrastinācijas saistība ar mācību motivāciju studentiem

OpenAIRE

Rauska, Rihards

2017-01-01

Bakalaura darba tēma “Prokrastinācijas saistība ar mācību motivāciju studentu vidū”. Darbā analizēta teorētiskā literatūra par motivāciju, mācību motivāciju un prokrastināciju. Bakalaura darba mērķis mācību motivācija un prokrastinācijas savstarpējās saistības izpēte un analīze. Pētījumā piedalījušies 50 respondentu vecumā no 19 – 40 gadu vecumam. Bakalaura darba pētījuma veikšanai izmantotas divas metodes: 1.Prokrastinācijas aptauja, (Procrastination scale Lay,1986), Latvijā aptauju adaptēj...

Žurnālista un viņa tiesību sargāt avotus definīcija Eiropas un starptautiskajās tiesībās

OpenAIRE

Šimkus, Anrijs

2015-01-01

Darba ietvaros autors pēta, kā mūsdienu starptautiskajās cilvēktiesībās ir definēts žurnālists. Autors konkrēti izvērtē divas žurnālista definēšanas teorijas, kuras sastopamas valstu un tiesu praksē. Pirmā ir institucionālā teorija, kas nosaka, ka žurnālistam jābūt saiknei ar profesionālu mediju vai žurnālistu organizāciju. Otrā ir funkcionālā teorija, kas nosaka, ka ikviena persona, kura pilda žurnālista funkcijas, būs žurnālists. Tāpat autors pēta, vai žurnālista galveno privilēģiju - tiesī...

EMODnet Thematic Lot n° 4 - Chemistry

DEFF Research Database (Denmark)

Beckers, Jean-Marie; Buga, Luminita; Debray, Noelie

2015-01-01

Data quality assurance and quality control (QA/QC) is an important issue in oceanographic data management, especially for the creation of multidisciplinary and comprehensive databases which include data from different and/or unknown origin covering long time periods. The data-collection methods i...... inconsistent data quality flags and the need for coordination and harmonization of practices. A dedicated workshop was organized to review the different practices and agree on a common methodology for data QA/QC and Diva products generation for EMODnet Chemistry....... will contribute considerably to the validation of large data collections. This report intends to be a reference manual for EMODnet Chemistry data QA/QC and the subsequent product generation. In fact, during the first data validation loop, each region adopted its own protocol and the results showed many...

Ekonomiskās reformas ietekme uz uzņēmējdarbību: Ķīna un Krievija līdz 1992.gadam

OpenAIRE

Zūle, Anda

2009-01-01

Mūsdienās daudzi ir aizmirsuši, ka pirms 20-30 gadiem pasaules ekonomika piedzīvoja milzu izmaiņas, kad divas komunistiskās valstis – Ķīna un Padomju Savienība – izlēma uzsākt ekonomisko pāreju no komandekonomikas uz tirgus ekonomiku. Diplomdarba pētījuma mērķis ir analizēt divu ekonomiskās reformas stratēģiju atšķirīgo ietekmi uz uzņēmējdarbības procesiem valstij pārejot no komandekonomikas uz tirgus ekonomiku. Lai analizētu un aprakstītu reformu ietekmi uz uzņēmējdarbību, tiek izmantots Ķīn...

Tulkošanas problēmas Antuāna de Sent-Ekziperī pasakā "Mazais princis"

OpenAIRE

Skromule, Ilze

2012-01-01

Tulkošana ir process, kurā darbojas divas valodas un kultūras, turklāt līdzās avota teksta autoram tajā iesaistīts vēl viens cilvēks – tulkotājs - ar savu valodas, kultūras un personisko pieredzi. Līdz ar to rodas šaubas par to, vai ir iespējams sniegt mērķa valodas lasītājiem nemainītu avota teksta informāciju. Lai izprastu iemeslus, kas šo procesu kavē, un meklētu iespējas šķēršļus mazināt, par pētījuma mērķi tiek izvirzīts veikt divu Antuāna de Sent-Ekziperī pasakas „Mazais princis” tulkoj...

Mājdzīvnieku (mājas – istabas dzīvnieku) pozicionēšana vegānismā

OpenAIRE

Dziedātāja, Elīna

2015-01-01

Bakalaura darbā “Mājdzīvnieku pozicionēšana vegānismā” tiek noskaidrots kā sadzīvo divas, savā starpā šķietami pretrunīgas prakses – vegānisms, kas ir kustība, kuras dalībnieki uzskata par morālu pienākumu respektēt dzīvnieku intereses, ar mājdzīvnieku jeb istabas – mājas dzīvnieku turēšanu. Vegānisms tiek skatīts kā viena no veģetārisma apakšgrupām, tomēr netiek saistīts tikai un vienīgi ar uzturu, bet lielākoties balstās uz ētisku izturēšanos pret dzīvniekiem. P...

Agresīvu datorspēļu spēlēšana saistībā ar pusaudžu un jauniešu agresiju

OpenAIRE

Vītols, Krists

2012-01-01

Bakalaura darba mērķis bija noskaidrot, vai pastāv nozīmīgas saistības starp agresīvu datorspēļu spēlēšanu, datorspēļu spēlēšanas biežumu un agresijas izpausmju līmeni pusaudžu un jauniešu vidū. Pētījumā tika aptaujāti 50 Latvijas skolu skolēni, vecumā no 12-16 gadiem. Pētījuma izlases tika viedotas pēc brīvprātības principa, pētījuma aptaujas tika izdalītas skolēnu klasēs. Pētījuma metodē tika izmantotas divas aptaujas: 1. “Datorspēļu aptauja” (Video Game Questionnaire, Anderson & ...

Pašprezentāciju saistība ar individuālismu-kolektīvismu

OpenAIRE

Vardanjana, Ilze

2015-01-01

Šī pētījuma ¬mērķis bija noskaidrot pašprezentāciju saistību ar individuālismu-kolektīvismu. Pētījuma ietvaros tika izvirzītas divas hipotēzes: 1) Jo izteiktāks individuālisms (idiocentrisms), jo izteiktāka būs pārliecinošo pašprezentāciju stratēģiju pielietošana. 2) Jo vairāk izteikts kolektīvisms (allocentrisms), jo raksturīgāka aizsargājošo pašprezentāciju stratēģiju izmantošana. Pētījumā piedalījās 83 respondenti vecumā no 19 līdz 27 gadiem. Izlases vidējais vecums M...

Brand “NIKE”, its signs and arguments: a study of applied semiotic

Directory of Open Access Journals (Sweden)

Vinícius dos Santos Souza

2016-05-01

Full Text Available This study elected as its research object the logo of the call sporting products company Nike; as regards to the Greek goodness Nice: diva of the victory. Based on Peirce's semiotics, our aim to identify and understand the perceptive and historical foundations responsible for sustaining the said logo as a sign capable of representing the company in their business purposes. We aim to demonstrate that the selection of logo for the company's founders follows a line of argument focused on building of semiotic links - perceptive and historical - between the brand, its products and the behavior of their consumers. The logo implies a dedicated language for the possibility of a communicative link between the product and the subjectivity of its consumer; so that the first former becomes logically part of thoughts and behaviors of the second.

Klientu attiecību pārvaldības sistēmas izveide autoservisam

OpenAIRE

Jaunzems, Ģirts

2012-01-01

Diplomdarba tēma ir Klientu attiecību pārvaldības sistēmas izveide autoservisam. Tā mērķis ir izstrādāt un ieviest pielāgotu klientu attiecību pārvaldības sistēmu nelielam autoservisam, tādējādi atvieglojot klientu un viņu darbības vēstures uzskaiti. Lai sasniegtu diplomdarba mērķi, darba autors izpētīja teorētiskos informācijas avotus, salīdzināja divas klientu pārvaldības sistēmas, kā arī izstrādāja sistēmu konkrētam uzņēmumam, veicot arī tās izmaksu analīzi. Diplomdarbā ir secināts, ...

Bērnu iztēles sekmēšana zīmēšanā vidējā pirmsskolas vecumā

OpenAIRE

Pavlovska, Santa

2017-01-01

Darba autors: Santa Pavlovska Darba temats: Bērnu iztēles sekmēšana zīmēšanā vidējā pirmsskolas vecumā. Darba veids: Kvalifikācijas darbs Studiju programma: Pirmā līmeņa profesionālās augstākās izglītības studiju programma Darba zinātniskais vadītājs: Dr. paed. Antra Randoha Darba struktūra: ievads, divas nodaļas, tabulas (3), attēli (8), secinājumi, literatūras un avotu saraksts (26). Darba apjoms 35 lpp. Atslēgas vārdi: iztēle, pirmsskolas vecums, 5-6 gadīgi bērni, zīmēšana. Pētījuma mērķis...

Pusaudžu agresivitātes saistība ar vecāku audzināšanas stilu.

OpenAIRE

Dambe, Agnese

2007-01-01

Šajā darbā tiek apskatīta viena no mūsdienu būtiskākajām problēmām- pusaudžu agresivitāte. Pētījuma mērķis bija noskaidrot, vai pastāv statistiski nozīmīgas saistības starp vecāku audzināšanas stilu un pusaudžu agresivitāti. Pētījuma izlasi veido 60 pusaudži (30 jaunietes un 30 jaunieši) no pilnām ģimenēm, vecumposmā no 15-17 gadiem. Pētījumā tika izmantotas divas pētījuma metodes- A.H. Bassa (A.H. Buss)- A. Darki (A. Durkee) aptaujas anketa agresīvu reakciju noteikšanai un ...

Evaluation of classical swine fever virus antibody detection assays with an emphasis on the differentiation of infected from vaccinated animals

DEFF Research Database (Denmark)

Schroeder, S.; von Rosen, Tanya; Blome, S.

2012-01-01

vaccinated animals (DIVA). The Chekit* CSF-Sero and the HerdChek* CSFV Ab, both of which detect antibodies against the E2 protein of classical swine fever virus (CSFV), had the highest sensitivity. Both tests were practicable and showed good reproducibility. Comparable sensitivity was shown by the Chekit......The aim of this study was to evaluate the general characteristics of commercially available enzyme-linked immunosorbent assays (ELISAs) to detect antibody against classical swine fever (CSF), as well as to assess their potential use as accompanying marker tests able to differentiate infected from......* CSF-Marker, an Erns ELISA. However, this test does not allow differentiation between antibodies directed against ruminant pestiviruses and those against CSFV. Therefore, it is not suitable for use with the chimeric marker vaccines tested. The PrioCHECK® CSFV Erns was the only ELISA suitable for use...

Anna Pavlova, danzatrice eurasiana? (I parte

Directory of Open Access Journals (Sweden)

Silvia Mei

2010-12-01

Full Text Available Abstract – IT Prima diva nella costellazione di nuove star dello spettacolo novecentesco, Anna Pavlova visse unicamente nello spirito e nella missione della danza come forma d’arte e stile di vita. Senza temere i rischi del solipsismo, si lancia nell’avventura di una compagnia tutta sua dopo il clamore parigino dei Ballets Russes. Il suo coraggio, la sua curiosità, il suo genio artistico la portano a viaggiare per i cinque continenti senza sosta, a scoprire danze tradizionali, a praticarle essa stessa, come quelle kabuki, apprese non senza sofferenze in Giappone nel 1922. Presentata nella vulgata come paladina della tradizione classicoaccademica, Pavlova può ostentare una biografia degna delle grandi danzatrici moderne a lei contemporanee, come una Duncan o una Ruth St. Denis (con quest’ultima in rapporto di competizione a distanza intorno al soggetto di Radha. Insieme ad una figura controversa e intrigante come quella del danzatore indiano Uday Shankar, crea un trittico di danze di ispirazione orientale all’insegna del rigore filologico e dell’integrazione linguistica, traccia della sua apertura e del rispetto di tradizioni teatrali altre. Abstract – EN Anna Pavlova, the first diva within the stars firmament of the 20th century, spent her life exclusively in the spirit of dance, intended as an art form and a life style, as if it were a mission. She threw herself into the adventure of leading her own company, after the Ballets Russes' European acclaim. Her courage, curiosity and artistic genius took her through five continents, endlessly searching for traditional dances that she learned with tremendous physical suffering, as in Japan with kabuki in 1922. She’s not simply a paladin of the academic tradition. She can in fact claim a biography and dance practice worthy of the most famous modern dancers who lived in her age, such as Duncan and St. Denis (with whom she was in a special competition, though after years, on the subject

Mutational analysis of foot and mouth disease virus nonstructural polyprotein 3AB-coding region to design a negative marker virus.

Science.gov (United States)

Bhatt, Mukesh; Mohapatra, Jajati K; Pandey, Laxmi K; Mohanty, Nihar N; Das, Biswajit; Prusty, Bikash R; Pattnaik, Bramhadev

2018-01-02

Inactivated purified whole virus vaccines are used for control of foot and mouth disease (FMD). ELISAs detecting antibodies to the nonstructural proteins (NSP), a marker of infection, are primarily used to differentiate FMD virus (FMDV) infected from vaccinated animals (DIVA). However, such DIVA assays have a limitation to their specificity since residual NSPs present in the relatively impure vaccines are suspected to induce an NSP-antibody response in the repeatedly vaccinated animals. Epitope-deleted negative marker vaccine strategy seems to have an advantage over the conventional vaccines in identifying the infected animals with accuracy. NSP 3AB contains an abundance of immunodominant B-cell epitopes of diagnostic importance. This study addresses the feasibility of producing 3AB-truncated FMDV mutant as a potential negative marker vaccine candidate. An infectious cDNA clone of FMDV serotype Asia 1 strain was used to engineer an array of deletion mutations in the established antigenic domain of 3AB. The maximum length of deletion tolerated by the virus was found to be restricted to amino acid residues 87-144 in the C-terminal half of 3A protein along with deletion of the first two copies of 3B peptide. The 3AB-truncated marker virus (Asia 1 IND 491/1997Δ3A 87-144 3B 1,2 +FLAG) demonstrated infectivity titres comparable to that of the parental virus in BHK-21 (log 10 7.42 TCID 50 /ml) and LFBK-α V β 6 (log 10 8.30 TCID 50 /ml) cell monolayer culture. The protein fragment corresponding to the viable deletion in the 3AB region was expressed in a prokaryotic system to standardize a companion assay (3A 87-153 3B 1,2 I-ELISA) for the negative marker virus which showed reasonably high diagnostic sensitivity (96.9%) and specificity (100% for naïve and 97.1% for uninfected vaccinated samples). The marker virus and its companion ELISA designed in this study provide a basis to devise a marker vaccine strategy for FMD control. Copyright © 2017 Elsevier B.V. All rights

InN/GaN short-period superlattices as ordered InGaN ternary alloys

International Nuclear Information System (INIS)

Kusakabe, Kazuhide; Imai, Daichi; Wang, Ke; Yoshikawa, Akihiko

2016-01-01

Coherent (InN) 1 /(GaN) n short-period superlattices (SPSs) were successfully grown through dynamic atomic layer epitaxy (D-ALEp) mode by RF-plasma molecular beam epitaxy (MBE), where GaN layer thicknesses n were thinned down to 4 monolayer (ML). After this achievement, we demonstrated quasi-ternary InGaN behavior in their photoluminescence (PL) spectra for the first time. It was found interestingly that GaN layer thickness of n = 4 ML was the criterion both for structural control and continuum-band formation. Although highly lattice-mismatched InN/GaN interfaces easily introduce relaxation in (InN) 1 /(GaN) 4 SPSs during growth depending on the dynamic surface stoichiometry condition, this problem was overcome by precise control/removal of fluid-like residual In/Ga metals on the growth front with in-situ monitoring method. The (InN) 1 /(GaN) n SPSs with n ≥ 7 ML showed a constant PL peak energy around 3.2 eV at 12 K, reflecting discrete electron/hole wavefunctions. On the other hand, the (InN) 1 /(GaN) 4 SPSs indicated the red-shifted PL peak at 2.93 eV at 12 K, which was attributed to the continuum-band state with increasing in the overlap of electrons/hole wavefunctions. This result is concluded that the (InN) 1 /(GaN) 4 SPSs can be considered as ordered InGaN alloys. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Nem holismo nem individualismo metodológicos: Marcel Mauss e o paradigma da dádiva

Directory of Open Access Journals (Sweden)

Caillé Alain

1998-01-01

Full Text Available O artigo se situa no contexto da crítica ao utilitarismo que vem sendo conduzida, desde o início dos anos 80, por um grupo de intelectuais reunidos em torno do MAUSS - Movimento Antiutilitarista nas Ciências Sociais, cujas idéias são divulgadas pela La Revue du MAUSS, publicada pela Editora La Découverte, em Paris. Alain Caillé procura resgatar a importância de Marcel Mauss no interior da escola sociológica francesa, ressaltando a contribuição deste autor clássico na sistematização inicial do paradigma do dom, que subsiste na modernidade, como o demonstram, em várias oportunidades, os colaboradores deste movimento antiutilitarista. Para Caillé, o paradigma do dom constitui o fundamento necessário de criação de uma teoria paradoxal e pluridimensional da ação, capaz de resolver a dicotomia clássica entre holismo e individualismo. No entanto, ressalta o diretor da Revue du MAUSS, na constituição do novo paradigma, as imbricações entre o dom e o simbolismo ainda permanecem imprecisas e algo misteriosas.

Loss mechanism of the superthermal electrons across the separatrix into the scrape-off layer in DIVA

International Nuclear Information System (INIS)

Yamamoto, Shin; Sengoku, Seio; Kimura, Haruyuki; Shimomura, Yasuo; Maeda, Hikosuke

1977-10-01

Behavior of superthermal electrons is investigated by using X-ray measurement and electrostatic energy analyser. Superthermal electrons are divided into two groups; i.e. high energy electrons (10 keV - 100 keV) and epithermal electrons (150 eV - 500 eV). Loss flux of the epithermal electrons is obtained and their loss is shown to be explained by destruction of magnetic surfaces near the separatrix due to non-axisymmetric perturbations. Two-dimensional path of high energy electrons is obtained and the effects of non-axisymmetric perturbations on the drift surface are described. (auth.)

A global analysis of erosion of sandy beaches and sea-level rise: An application of DIVA

Science.gov (United States)

Hinkel, Jochen; Nicholls, Robert J.; Tol, Richard S. J.; Wang, Zheng B.; Hamilton, Jacqueline M.; Boot, Gerben; Vafeidis, Athanasios T.; McFadden, Loraine; Ganopolski, Andrey; Klein, Richard J. T.

2013-12-01

This paper presents a first assessment of the global effects of climate-induced sea-level rise on the erosion of sandy beaches, and its consequent impacts in the form of land loss and forced migration of people. We consider direct erosion on open sandy coasts and indirect erosion near selected tidal inlets and estuaries, using six global mean sea-level scenarios (in the range of 0.2-0.8 m) and six SRES socio-economic development scenarios for the 21st century. Impacts are assessed both without and with adaptation in the form of shore and beach nourishment, based on cost-benefit analysis that includes the benefits of maintaining sandy beaches for tourism. Without nourishment, global land loss would amount to about 6000-17,000 km2 during the 21st century, leading to 1.6-5.3 million people being forced to migrate and migration costs of US 300-1000 billion (not discounted). Optimal beach and shore nourishment would cost about US 65-220 billion (not discounted) during the 21st century and would reduce land loss by 8-14%, forced migration by 56-68% and the cost of forced migration by 77-84% (not discounted). The global share of erodible coast that is nourished increases from about 4% in 2000 to 18-33% in 2100, with beach nourishment being 3-4 times more frequent than shore nourishment, reflecting the importance of tourism benefits. In absolute terms, with or without nourishment, large countries with long shorelines appear to have the largest costs, but in relative terms, small island states appear most impacted by erosion. Considerable uncertainty remains due to the limited availability of basic coastal geomorphological data and models on a global scale. Future work should also further explore the effects of beach tourism, including considering sub-national distributions of beach tourists.

Comparing cosmic web classifiers using information theory

Energy Technology Data Exchange (ETDEWEB)

Leclercq, Florent [Institute of Cosmology and Gravitation (ICG), University of Portsmouth, Dennis Sciama Building, Burnaby Road, Portsmouth PO1 3FX (United Kingdom); Lavaux, Guilhem; Wandelt, Benjamin [Institut d' Astrophysique de Paris (IAP), UMR 7095, CNRS – UPMC Université Paris 6, Sorbonne Universités, 98bis boulevard Arago, F-75014 Paris (France); Jasche, Jens, E-mail: florent.leclercq@polytechnique.org, E-mail: lavaux@iap.fr, E-mail: j.jasche@tum.de, E-mail: wandelt@iap.fr [Excellence Cluster Universe, Technische Universität München, Boltzmannstrasse 2, D-85748 Garching (Germany)

2016-08-01

We introduce a decision scheme for optimally choosing a classifier, which segments the cosmic web into different structure types (voids, sheets, filaments, and clusters). Our framework, based on information theory, accounts for the design aims of different classes of possible applications: (i) parameter inference, (ii) model selection, and (iii) prediction of new observations. As an illustration, we use cosmographic maps of web-types in the Sloan Digital Sky Survey to assess the relative performance of the classifiers T-WEB, DIVA and ORIGAMI for: (i) analyzing the morphology of the cosmic web, (ii) discriminating dark energy models, and (iii) predicting galaxy colors. Our study substantiates a data-supported connection between cosmic web analysis and information theory, and paves the path towards principled design of analysis procedures for the next generation of galaxy surveys. We have made the cosmic web maps, galaxy catalog, and analysis scripts used in this work publicly available.

Bērnu intelektuālās un emocionālās vajadzības un to apmierināšana Latvijas Televīzijas raidījumā “Kas te? Es te!"

OpenAIRE

Dubra, Elīna

2009-01-01

Bakalaura darba “Bērnu intelektuālās un emocionālās vajadzības un to apmierināšana Latvijas Televīzijas raidījumā “Kas te? Es te!” sākumā ir izvirzītas divas hipotēzes, kas paredz, ka raidījuma “Kas te? Es te!” skatīšanās veicina bērnu intelektuālo un emocionālo attīstību. Darba teorētiskajā daļā aplūkoti cilvēka attīstības vecumposmi pēc Eriksona, intelektuālās un emocionālās attīstības aspekti un īpatnības, lietojuma-apmierinājuma teorija un Alberta Banduras izstrādātā soc...

Comparing cosmic web classifiers using information theory

International Nuclear Information System (INIS)

Leclercq, Florent; Lavaux, Guilhem; Wandelt, Benjamin; Jasche, Jens

2016-01-01

We introduce a decision scheme for optimally choosing a classifier, which segments the cosmic web into different structure types (voids, sheets, filaments, and clusters). Our framework, based on information theory, accounts for the design aims of different classes of possible applications: (i) parameter inference, (ii) model selection, and (iii) prediction of new observations. As an illustration, we use cosmographic maps of web-types in the Sloan Digital Sky Survey to assess the relative performance of the classifiers T-WEB, DIVA and ORIGAMI for: (i) analyzing the morphology of the cosmic web, (ii) discriminating dark energy models, and (iii) predicting galaxy colors. Our study substantiates a data-supported connection between cosmic web analysis and information theory, and paves the path towards principled design of analysis procedures for the next generation of galaxy surveys. We have made the cosmic web maps, galaxy catalog, and analysis scripts used in this work publicly available.

Effect of Ultrasound-Guided Placement of Difficult-to-Place Peripheral Venous Catheters

DEFF Research Database (Denmark)

Partovi-Deilami, Kohyar; Nielsen, Jesper K.; Møller, Ann M.

2016-01-01

operated by nurse anesthetists for these patients. This prospective observational study with a pre/post design focused on inpatients with DIVA referred for PVC placement, a service provided by nurse anesthetists in most Scandinavian hospitals. The rate of success, procedure time, number of skin punctures......) with ultrasound. Procedure time was reduced from 20 to 10 minutes, discomfort was unchanged, and the median number of skin punctures decreased from 3 to 2. The incidence of central venous catheter placement dropped from 34% to 7%. Implementation of a training program and a mobile service in which nurse......, discomfort, catheter size, location, and incidence of central venous catheter placement are reported before and after implementation of a training program and a mobile service using ultrasound to place difficult-to-place PVCs. The success rate increased from 0% (0 of 33 patients) to 83% (58 of 70 patients...

Evolución biogeográfica de los Pachydeminae paleárticos (Coleoptera, Scarabaeoidea mediante análisis de dispersión-vicarianza

Directory of Open Access Journals (Sweden)

Sanmartín, Isabel

2003-12-01

Full Text Available The beetle subfamily Pachydeminae Reitter, 1902 is one of the least-known subfamilies of Melolonthidae or “leaf-chafers” (Coleoptera, Scarabaeoidea. Some species of Pachydeminae have recently been described as agricultural pests of olive trees. The Pachydeminae are distributed in all major zoogeographical regions (except Australia and India but their distribution is very disjunct. In the Palearctic region, they are distributed across southern Eurasia from the Canary Islands to China, including southern Europe (except France and Italy, North Africa, Asia Minor, Middle East, Iran-Afghanistan, Caucasus, and Central Asia. The majority of species occur in the southwestern Palearctic, with only a few species in China. As in the rest of Melolonthidae subfamilies (Browne & Scholtz, 1999, phylogenetic relationships within the Pachydeminae are poorly resolved. Recently, Sanmartín & Martín-Piera, (2003 reviewed the systematics of the Palearctic genera, and proposed the first phylogenetic hypothesis within the subfamily. This study summarizes the conclusions of Sanmartín (1998 and Sanmartín (2003, which reconstructed the biogeographic history of the subfamily Pachydeminae in the Palearctic region using dispersalvicariance analysis (DIVA, Ronquist, 1996, 1997. This method reconstructs the ancestral distribution in a given phylogeny based on a vicariance model, while allowing dispersal and extinction to occur. Unlike other methods, DIVA does not enforce area relationships to conform to a hierarchical “area cladogram” so it can be used to reconstruct “reticulate” biogeographic scenarios. DIVA optimal reconstructions suggest that the ancestor of Pachydeminae was originally present in the south-eastern Mediterranean region, including North Africa, the Middle East, the Iranian Plateau, and the Balkans/Anatolian region. During the Oligocene-Miocene, the collision between the Arabian, African, and Eurasian Plates resulted in the appearance of

SIA „AUTO ATVARS” darbība Latvijas autotirgū.

OpenAIRE

Spila, Andis

2007-01-01

Pēdējo gadu laikā auto tirdzniecība ir viena no progresējošākajām nozarēm Latvijas tautsaimniecībā. Attīstoties jaunu automašīnu tirdzniecībai Latvijā attīstās arī citas vispārējai Latvijas attīstībai svarīgas nozares, tādas kā apdrošināšana, kreditēšana, būvniecība u.c. Pašreiz Latvijā piedāvājumā pārstāvētas praktiski visas pasaulē populārākās automašīnu markas, atsevišķas markas tirgo pat divas un vairāk kompānijas. Iespējams, jau pēc dažiem gadiem būs vēl vairāk jaunu auto ti...

Recent activity of the regional geologic structures in western Slovenia

Directory of Open Access Journals (Sweden)

Miloš Bavec

2007-06-01

Full Text Available Several important geological structures in the western Slovenia were identifiedas active and their activity was quantified. Geologic interpretation is based on the analysis of repeated leveling line campaigns data along the Sečovlje–Bled polygon. Taking intoaccount the limitations of the method – only the vertical component of displacement is measured – the following structures were identified as active:a juvenile syncline between Strunjan and Koper, the Kras Imbricate Structure, the Diva~a fault, the Ra{a fault, the Southalpine Front and the Julian Alps thrust. Vertical movement rate is relative, calculated with respect to the benchmark in Sečovlje. The largest uplift rate difference between Sečovlje and Bled is 7 mm/a.Vertical Geodynamic Activity (VGA is introduced as a link between geologic interpretation of geodetic measurements on one side and possible applications on the other as well as a mean of comparison between tectonically active regions.

Experimental study of the fast wave propagation in TFR

International Nuclear Information System (INIS)

1981-02-01

Several experiments (PLT, DIVA, ERASMUS, TFR) have shown that the heating mechanism of ICRF is dominated in Tokamaks by the presence of the ion-ion hybrid layer. The first experimental evidence of this effect came from propagation studies: a very strong damping was observed on magnetic probes since the hybrid layer was inside the plasma. Comparison with simple models which do not take into account boundary conditions have been undertaken. Recently a new theoretical model has been developped. Based on a plane, inhomogeneous, bounded plasma, it shows that the radial structure of the fast wave and hence the loading impedance of the launching coil depends on the position of the hybrid layer with respect to the plasma boundaries. This result is obtained by solving the wave equation, in the cold plasma approximation. We present here, a serie of experiments, performed in TFR. It confirms the validity of that model underlining thus the importance of radial eigenmodes, when the wave conversion layer is inside the plasma

New developments of the GANIL control system

International Nuclear Information System (INIS)

Lecorche, E.

1985-10-01

Since its first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of programmable Controllers and INTEL 8080 equipped autonomous CAMAC Controllers. After a brief description of the GANIL Control System, this paper will lay emphasis on the major improvements undertaken along four main directions: a) Upgrading the Control Computer. b) Introducing more powerful local intelligence. A microprocessorized autonomous CAMAC Controller called ''DIVA 68C'' using the 68000 microprocessor embedded in a VME card has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. (c) Making human-machine dialog smarter with use of color graphic terminals. d) Meeting the requirements of the coming second injector. In this purpose a fully equipped auxiliary console is being installed near the main console for operation by summer 1985

Composition profiles of several contaminated and cleaned surfaces of gold thick films on copper plates by Auger electron and secondary ion mass spectroscopies

International Nuclear Information System (INIS)

Komiya, S.; Mizuno, M.; Narusawa, T.; Maeda, H.; Yoshikawa, M.

1974-01-01

Preparation and evaluation of a clean Au film are investigated. Development of a preparation method for obtaining clean surface on a copper shell in the JFT-2a (DIVA) TOKAMAK toroidal vacuum chamber is the aim of the present work. Au films prepared by ion plating and vacuum evaporation have been analysed by a cylindrical mirror Auger electron analyser in combination with a quadrupole mass spectrometer during 2 keV Xe ion bombardment from a sputter ion gun over the whole range of thickness of several microns. Contaminants are found to segregate on the top surface and at the interface. To expose a clean Au surface by the ion bombardment, surface layers within 1000 A had to be removed from the surfaces contaminated by touching with either a naked hand or a nylon glove or covered by a small amount of Ti. Mutual diffusions across the interfaces are also analyzed as a function of the substrate temperature. A Nb sandwich layer inhibites effectively the mutual diffusion. (auth.)

Grafiskā stāstījuma uzbūve un trauma Hāleda Hoseinī grafiskajā romānā “Pūķa ķērājs”

OpenAIRE

Vanaga, Alīna

2016-01-01

Hāleda Hoseinī grafiskais romāns “Pūķa ķērājs”demonstrē grafisko romānu spēju vienlaicīgi uzrunāt lielu cilvēku daudzumu un tajā pašā laikā izteikt neaprakstāmo, kas apliecina to, ka grafiskie romāni ļoti labi prot darīt saprotamas tādas neaprakstāmas tēmas, kā trauma. Tādēļ, šī maģistra darba mērķis ir noteikt, kā grafiskā stāstījuma uzbūve attēlo traumu Hāleda Hoseinī grafiskajā romāna “Pūķa ķērājs” un kādu rezultātu tas rada. Iepriekš minētā mērķa sasniegšanai tika izvēlētas divas pētīšana...

Segmentation of turbo generator and reactor coolant pump vibratory patterns: a syntactic pattern recognition approach

International Nuclear Information System (INIS)

Tira, Z.

1993-02-01

This study was undertaken in the context of turbogenerator and reactor coolant pump vibration surveillance. Vibration meters are used to monitor equipment condition. An anomaly will modify the signal mean. At the present time, the expert system DIVA, developed to automate diagnosis, requests the operator to identify the nature of the pattern change thus indicated. In order to minimize operator intervention, we have to automate on the one hand classification and on the other hand, detection and segmentation of the patterns. The purpose of this study is to develop a new automatic system for the segmentation and classification of signals. The segmentation is based on syntactic pattern recognition. For the classification, a decision tree is used. The signals to process are the rms values of the vibrations measured on rotating machines. These signals are randomly sampled. All processing is automatic and no a priori statistical knowledge on the signals is required. The segmentation performances are assessed by tests on vibratory signals. (author). 31 figs

Doctoral e-Theses; experiences in harvesting on a national and European level

CERN Multimedia

CERN. Geneva

2007-01-01

In many countries in Europe doctoral e-theses are an integrated part of institutional repositories, which have been set up in recent years. In some countries they have been harvested on a national level, like in the Netherlands with the ‘Promise of Science’ portal (http://www.darenet.nl/promiseofscience) . In October 2006 SURFfoundation (The Netherlands), JISC (UK) and DIVA (funded through BIBSAM in Sweden) started a common project to harvest repositories with e-theses on an international scale and to set up a freely accessible European portal and test in practice the interoperability. The project, which aims at creating a value added service for doctoral e-Theses, will finish in June 2007. In the presentation we will show some lessons learned and the first results of the Demonstrator, an interoperable portal of European doctoral e-theses in five countries: Denmark, Germany, the Netherlands, Sweden and the UK. Furthermore, we will present the developments regarding the European coordination of doctoral...

Canções, filmes e divas de Pubis Angelical na música de Charly Garcia (1972-1982

Directory of Open Access Journals (Sweden)

Júlio Ogas

2011-06-01

Full Text Available In the first stage of Charly García‟s production, the cinema plays an important role. Several single songs, a thematic record and the music of two films are clear indications in this regard. The meaning space that opens from this subject allows appreciating some ideas that prevail in the author's proposal. Both the literal and the symbolic languages combine to convey a message of change to man extent but deeply involved in the social environment of his time.

Bluetongue virus with mutated genome segment 10 to differentiate infected from vaccinated animals: A genetic DIVA approach

NARCIS (Netherlands)

Rijn, van P.A.; Water, van de S.G.P.; Gennip, van H.G.P.

2013-01-01

Bluetongue virus (BTV) includes 24 serotypes and recently even more serotypes are proposed. Mass vaccination campaigns highlight the need for differential diagnostics in vaccinated populations. Bluetongue disease is routinely diagnosed by serological and virological tests by which differentiation

Entrainment and impingement of aquatic fauna at cooling water system of Madras Atomic Power Station (MAPS)

International Nuclear Information System (INIS)

Barath Kumar, S.; Das, N.P.I.; Satpathy, K.K.

2015-01-01

Marine organisms get impinged to the intake screens of Madras Atomic Power Station (MAPS) due to the suction force of the cooling water system of the power plant. The present work has studied the loss of aquatic organism at MAPS due to impingement at cooling water screens. In total 67 species of marine faunas impinged on the water intake screens of MAPS during the study. The proportion of fish, shrimp, crab, jellyfish and others, with respect to the total biomass of impinged organisms are 1.59 % (33 species), 0.30% (9), 2.77 % (16), 95.10% (3) and 0.24% (4), respectively. Jellyfishes were observed to be the largest entrained group covering around 44.85% of individual and constituting almost 94.82 % of biomass recorded during the study period and sea nettle jelly (Chrysaora quinquecirrha) was impinged with highest frequency. The diel study shows higher impingement occurred during night time, on full moon day and at low tides in contrast to their counterparts. Fishes accounts for 14.84 % of individual count and mere 1.67 % of biomass. Totally 33 number of fish species were observed. The highest impinged species were pony fishes (Secutor ruconius, Secutor insidiator, Photopectoralis bindus, Alepes kleinii and Leiognathus equulus) (21% occurrence). These few entrained fishes are mostly very small in size and have less commercial value. The total loss of marine fauna by impingement during study period was estimated to be 4779 (or 463.46 kg). The present data when compared with the impingement data from other coastal power plants, shows that the impinged fish biomass at MAPS cooling water system is much less than the other temperate and tropical power plants. (author)

Burnsov antifonar: izvješće o projektu

Directory of Open Access Journals (Sweden)

Anna Kijas

2017-01-01

Full Text Available Burnsov antifonar (burnsantiphoner.bc.edu suradnički je projekt između Digital Scholarship Group i osoblja knjižnice Boston College University Libraries, muzikologa Michaela Noonea te nekoliko vanjskih suradnika, uključujući osoblje baze podataka CANTUS. U ljeto 2015. započeto je s kodiranjem franjevačkog antifonara iz četrnaestog stoljeća (http://hdl.handle.net/2345/2231, koristeći Music Encoding Initiative (MEI standard te s razvojem internet stranice otvorenog sadržaja u svrhu prezentacije rukopisa kao interaktivnog objekta za istraživanje i znanstvenu uporabu. Izvorni Antifonar postoji u rukopisnom obliku ukoričen kožom prekrivenim daščicama i sastoji se od 119 pergamentnih folija s tekstualnim i notnim zapisima antifona i responzorijala za cjelokupni godišnji kalendar svetačkih svetkovina (sanktoral. Ovo izvješće raspravlja o razvoju projekta i njegovim glavnim ciljevima, koji uključuju: 1. učiniti Antifonar interaktivnim izradom internetske stranice otvorenog i dostupnog sadržaja pomoću Diva.js, dinamičnog prezentacijskog sloja u kojem se može pretraživati i prikazivati sadržaj (podaci, notacija, XML/MEI i multimedija; 2. korištenje i razvoj tehnologije otvorenoga koda u svrhu poticanja i podupiranja daljnjeg razvoja unutar open source zajednice, kao i dijeljenje dokumentacije i podataka; 3. dijeljenje projektnih podataka sa znanstvenom zajednicom preko suradnje s CANTUS-om , bazom podataka za crkveno pjevanje na latinskom jeziku; te 4. razvoj programa, tijek radova i dokumentacije u svrhu informiranja budućih projekata koji se koriste sličnom tehnologijom. Proučava se tijek rada na transkripciji i kodiranju otprilike 1.500 incipita za ovaj projekt i bazu podataka CANTUS, uključujući neke poteškoće koje su se očitovale kroz rad na projektu. Osim toga, raspravlja se o ključnim rješenjima infrastrukture i aplikacija koje se primjenjuju u ovom projektu, uključujući implementaciju Diva.js kao

Use of M2e ELISAs for longitudinal surveillance of commercial poultry in Indonesia vaccinated against highly pathogenic avian influenza.

Science.gov (United States)

Wibowo, Michael Haryadi; Tarigan, Simson; Sumarningsih; Artanto, Sidna; Indriani, Risa; Anggoro, Dito; Putra, Cahyaditya Pratama; Idris, Syafrison; Untari, Tri; Asmara, Widya; Tabbu, Charles Rangga; Ignjatovic, Jagoda

2017-11-01

In countries where highly pathogenic avian influenza virus (HPAIV) H5N1 is endemic and controlled by vaccination, post-vaccination serological monitoring is essential to differentiate vaccinated poultry from those that are infected. The objectives of this study were to validate two experimental ELISAs that detect antibodies raised against the M2e protein of avian influenza virus that can be used for DIVA purposes. Results from the sM2e and tM2e ELISAs were compared with other conventional tests for the detection of H5N1influenza virus (virus isolation and RT-PCR) using samples collected from 16 commercial flocks in Indonesia. These comprised vaccinated layers aged between 18 and 68 weeks old that were sampled at ten-weekly intervals. A small number of sera were positive in sM2e and tM2e ELISA, 14 (0.6%) and 17 (0.7%) respectively, with low OD 420 (0.1-0.3), but only 4 sera were positive in both tests. At the flock level, the incidence of M2e positive sera was low (4%), well below previously established minimum of 40% for an HPAIV H5N1-infected flock. Conventional M and H5 gene RT-PCRs indicated that none of 16 flocks were infected at any time during the study. No virus was isolated from any of the 480 pooled swab samples, except from one, for which the combined data analysis suggest to be the result of a laboratory cross-contamination. Clinical disease, mortalities or reduction in production performance, indicative of field H5N1 challenge, were not observed either in any of the flocks. Birds from two surveyed flocks, challenged in the laboratory with an Indonesian HPAIV H5N1 developed M2e antibodies in 50% and 55% of surviving birds with OD 420 in the range of 0.35-1.47 in tM2e ELISA, confirming the validity of the criteria established for use of M2e ELISA for DIVA purposes. Overall these results showed that the tM2e ELISA could be a useful monitoring tool to ascertain freedom from H5N1 infections in vaccinated commercial poultry. Copyright © 2017 Elsevier B

General review of diagnostic systems in EDF PWR units

International Nuclear Information System (INIS)

Chevalier, R.; Brasseur, S.; Ricard, B.

1998-01-01

Since the beginning of the French nuclear program, Electricite de France (EDF) has looked for ways to improve the availability and safety of its nuclear units. Therefore, monitoring systems on turbogenerators, reactor coolant pumps, primary circuits and core internal structures were designed by the Research and Development Division and implemented with technologies available during the 1970's. However, mainly because of difficulties for data interpretation by plant personnel, EDF subsequently decided to design and develop different tools to help plant operators to process a diagnosis: - a new generation of the Monitoring and Diagnostic System called PSAD, - expert systems for diagnosis on reactor coolant pumps (RCP) 'DIAPO' and turbogenerator units (TG) 'DIVA', - diagnostic guides written for most equipment pending the installation of new monitoring and diagnosis systems. The first version of PSAD, installed in five units, performs on-line monitoring of the turbogenerator shaft line, steam inlet valves, the reactor coolant pumps and the generator stator. The second version not yet implemented, will include Loose Part Detection (LPD) and Core Internal Structure Monitoring (CISM). The level of diagnosis achieved by PSAD depends on the component monitored. The TG and RCP monitoring functions of PSAD compute high level diagnosis descriptors such as natural frequencies and long term trends but do not elaborate a diagnosis automatically. However, a diagnostic assistance window is available on-line, whenever a warning message is displayed, whether for immediate or later action. The window presents a diagnostic approach whose purpose is to find the causes of the symptoms observed. This diagnosis approach is automated in the DIVA and DIAPO expert systems. Numerous potential faults can be identified for both systems thanks to a hierarchy of abnormal situations. The user interactively answers questions when information is needed to progress in the diagnosis. The resulting

DINHEIRO, TECIDOS, RUM E A ESTÉTICA DO ECLIPSAMENTO EM SAAMAKA

Directory of Open Access Journals (Sweden)

Rogério Brittes W. Pires

Full Text Available Resumo O artigo trata dos businenge (maroons, quilombolas saamaka do Alto Suriname. Parto de um tema clássico da antropologia - a separação nem sempre clara entre dádivas e mercadorias - e um aspecto particular da vida econômica nesta localidade - a rejeição do uso de dinheiro em determinadas esferas de circulação de objetos, serviços e palavras - como problemas. A ideia é compreender os motivos pelos quais, mesmo num contexto econômico crescentemente monetizado e integrado à economia capitalista global, há certos tipos de trocas nas quais o papel-moeda não deve circular de forma explícita, e nas quais fazem o papel de “moeda” objetos cuja fabricação é estrangeira. Busco compreender como é traçada, em Saamaka, a exterioridade e a interioridade, e de que forma o dinheiro é marcado como externa, enquanto certas “dádivas”, como rum e tecido, são feitas internas.

No lower cognitive functioning in older adults with attention-deficit/hyperactivity disorder.

Science.gov (United States)

Semeijn, E J; Korten, N C M; Comijs, H C; Michielsen, M; Deeg, D J H; Beekman, A T F; Kooij, J J S

2015-09-01

Research illustrates cognitive deficits in children and younger adults with attention-deficit/hyperactivity disorder (ADHD). Few studies have focused on the cognitive functioning in older adults. This study investigates the association between ADHD and cognitive functioning in older adults. Data were collected in a cross-sectional side study of the Longitudinal Aging Study Amsterdam (LASA). A diagnostic interview to diagnose ADHD was administered among a subsample (N = 231, age 60-94). ADHD symptoms and diagnosis were assessed with the Diagnostic Interview for ADHD in Adults (DIVA) 2.0. Cognitive functioning was assessed with tests in the domains of executive functioning, information processing speed, memory, and attention/working memory. Regression analyses indicate that ADHD diagnosis and ADHD severity were only negatively associated with cognitive functioning in the attention/working memory domain. When adjusting for depression, these associations were no longer significant. The study shows that ADHD in older adults is associated with lower cognitive functioning in the attention/working memory domain. However, this was partly explained by depressive symptoms.

Ocean currents and acoustic backscatter data from shipboard ADCP measurements at three North Atlantic seamounts between 2004 and 2015

Directory of Open Access Journals (Sweden)

Christian Mohn

2018-04-01

Full Text Available Seamounts are amongst the most common physiographic structures of the deep-ocean landscape, but remoteness and geographic complexity have limited the systematic collection of integrated and multidisciplinary data in the past. Consequently, important aspects of seamount ecology and dynamics remain poorly studied. We present a data collection of ocean currents and raw acoustic backscatter from shipboard Acoustic Doppler Current Profiler (ADCP measurements during six cruises between 2004 and 2015 in the tropical and subtropical Northeast Atlantic to narrow this gap. Measurements were conducted at seamount locations between the island of Madeira and the Portuguese mainland (Ampère, Seine Seamount, as well as east of the Cape Verde archipelago (Senghor Seamount. The dataset includes two-minute ensemble averaged continuous velocity and backscatter profiles, supplemented by spatially gridded maps for each velocity component, error velocity and local bathymetry. The dataset is freely available from the digital data library PANGAEA at https://doi.pangaea.de/10.1594/PANGAEA.883193. Keywords: Seamounts, Northeast Atlantic, Shipboard ADCP, CODAS processing, DIVA gridding

Validation of Code ASTEC with LIVE-L1 Experimental Results

International Nuclear Information System (INIS)

Bachrata, Andrea

2008-01-01

The severe accidents with core melting are considered at the design stage of project at Generation 3+ of Nuclear Power Plants (NPP). Moreover, there is an effort to apply the severe accident management to the operated NPP. The one of main goals of severe accidents mitigation is corium localization and stabilization. The two strategies that fulfil this requirement are: the in-vessel retention (e.g. AP-600, AP- 1000) and the ex-vessel retention (e.g. EPR). To study the scenario of in-vessel retention, a large experimental program and the integrated codes have been developed. The LIVE-L1 experimental facility studied the formation of melt pools and the melt accumulation in the lower head using different cooling conditions. Nowadays, a new European computer code ASTEC is being developed jointly in France and Germany. One of the important steps in ASTEC development in the area of in-vessel retention of corium is its validation with LIVE-L1 experimental results. Details of the experiment are reported. Results of the ASTEC (module DIVA) application to the analysis of the test are presented. (author)

In-Vessel Retention via External Reactor Cooling

Energy Technology Data Exchange (ETDEWEB)

Bachrata, Andrea [CTU in Prague, Faculty of nuclear sciences and physical engineering, V Holesovickach 2 180 00, Prague 8 (Czech republic)

2008-07-01

In-vessel (corium) retention (IVR) via external reactor pressure vessel (RPV) cooling is considered to be an effective severe accident management strategy for corium localisation and stabilisation. The main idea of IVR strategy consists in flooding the reactor cavity and transferring the decay heat through the wall of RPV to the recirculating water and than to the atmosphere of the containment of nuclear power plant. The aim of this strategy is to localise and to stabilise the corium inside the RPV. Not using this procedure could destroy the integrity of RPV and might cause the interaction of the corium with the concrete at the bed of the reactor cavity. Several experimental facilities and computer codes (MVITA, ASTEC module DIVA and CFD codes) were applied to simulate the IVR strategy for concrete reactor designs. The necessary technical modifications concerning the implementation of IVR concept were applied at the Loviisa NPP (VVER-440/V213). This strategy is also an important part of the advanced reactor designs AP600 and AP1000. (authors)

Golden Jubilee Event for Cinema Fans

CERN Multimedia

2004-01-01

As part of the Organisation's Fiftieth Anniversary celebrations the CERN CineClub will be showing a special series of films beginning with works by British, French, German, Norwegian and Spanish directors. The Club hopes to include films from all of the Member States in the programme. CERN's linguistic and cultural diversity will be celebrated from mid-February onwards when the CERN CineClub, whose summer English language film season will be familiar to many of you, plans to show a series of films from CERN's 20 Member States. The programme marks the CineClub's contribution to CERN's fiftieth anniversary festivities. The first film, "Four weddings and a funeral" (Mike Newell, 1994), will be shown in the Main Auditorium on 12 February. Next in the series will be films from Germany (Himmel über Berlin, or "The Wings of Desire", by Wim Wenders, 1987), Spain (Los Lunes al Sol, or "Mondays in the Sun", by Fernando Leon de Aranoa, 2002), France ( Diva , by Jean Jacques Beinex, 1981) and Norway (Elling, b...

Apmierinātības ar dzīvi saistība ar sociālo salīdzināšanu.

OpenAIRE

Tamsone, Liliāna

2011-01-01

Šajā bakalaura darbā tika izvirzīti trīs pētījuma jautājumi: 1)Kāda saistība pastāv starp apmierinātību ar dzīvi un sociālās salīdzināšanas līmeni? 2)Kāda saistība pastāv starp apmierinātību ar dzīvi un augšupejošo salīdzināšanu? 3)Kāda saistība pastāv starp apmierinātību ar dzīvi un lejupejošo salīdzināšanu? Pētījumā piedalījās 58 respondenti – 12 vīrieši un 46 sievietes vecumā no 25 līdz 45 gadiem. Respondentu vidējais vecums ir M = 31,67, SD = 5,11. Pētījuma instrumentārijs iekļauj divas m...

À PARTE: As Ciências Sociais no Brasil - trajetória, história e institucionalização

Directory of Open Access Journals (Sweden)

José Segatto

2012-04-01

Full Text Available <div>A trajetória do pensamento social no Brasil remonta à segunda metade do século XIX e envolve muitas correntes, linhagens e famílias intelectuais que enformam as Ciências Sociais no Brasil. Por isso, há controvérsias quanto à fundação das Ciências Sociais, considerada, de um lado, por meio da trajetória histórica, e, de outro, pela institucionalização do trabalho científico. O debate ganha complexidade quando são considerados os marcos fundadores, as características, o significado e as implicações dessa institucionalização que, longe de esclarecer a questão, cria novos problemas para o entendimento e avaliação do processo. Rediscutir as circunstâncias histórico-sociais e as configurações intelectuais de sua fundação e desenvolvimento, entendemos ser pertinente e necessário, sendo esse o propósito deste artigo.