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Sample records for al mono obeso

  1. Algunas variables bioquímicas en adolescentes obesos con antecedente de bajo peso al nacer

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    María del Carmen Valdés Alonso

    Full Text Available Introducción: la malnutrición intraútero ha sido postulada con vinculación a afecciones del desarrollo embrionario que determinan el desarrollo ulterior de obesidad, diabetes mellitus tipo 2, dislipidemias, disfunción mitocondrial y aterosclerosis. Objetivo: determinar las complicaciones metabólicas en adolescentes obesos con antecedentes de bajo peso al nacer. Métodos: estudio descriptivo y de corte transversal. Se incluyeron 50 pacientes obesos, con antecedentes de bajo peso al nacer y embarazo a término, de ambos sexos, en las edades comprendidas entre 9 y 17 años de edad, que asistieron a la consulta externa del servicio de Endocrinología del Hospital Pediátrico Docente "Juan Manuel Márquez", en el período comprendido de enero de 2011 a enero de 2012. Se realizaron determinaciones de colesterol, triglicéridos, aminotransferasas hepáticas, glucemia, e insulinemia en ayunas y posprandial de dos horas. Resultados: las variables bioquímicas estudiadas no mostraron diferencias entre los puntos de corte utilizados para clasificar el peso al nacer. La transaminasa glutámico pirúvica mostró valores más altos en los adolescentes entre 15 y 17 años de edad. Conclusiones: la hipertrigliceridemia fue más elevada en el sexo femenino, mientras que la hiperglucemia y la hiperinsulinemia lo fueron en el masculino.

  2. Candelario Obeso

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    Julio Añez

    1962-11-01

    Full Text Available Uno de los tipos más distinguidos de nuestra juventud inteligente fue sin duda Candelario Obeso. Nacido en condiciones de fortuna nada aparentes para hacer una carrera brillante en el mundo de las letras, supo vencer todo linaje de obstáculos con una valiente resignación de que hay pocos ejemplos, hasta que llegó a ser estimado generalmente por la excelencia de su carácter y admirado por las ricas facultades de su inteligencia.

  3. Assistência ao paciente obeso mórbido submetido à cirurgia bariátrica: dificuldades do enfermeiro Asistencia al paciente obeso mórbido sometido a la cirugía bariátrica: dificultades del enfermero Perioperative care for morbid obese patient undergoing bariatric surgery: challenges for nurses

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    Denise Spósito Tanaka

    2009-10-01

    Full Text Available OBJETIVO: Identificar as dificuldades de enfermeiros de centro cirúrgico ao assistir pacientes obesos mórbidos submetidos à cirurgia bariátrica no período transoperatório. MÉTODOS: A amostra constou de 70 enfermeiros com experiência em assistência ao paciente obeso mórbido. Os dados foram coletados durante o 7º Congresso Brasileiro de Enfermeiros de Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização por meio de um questionário. RESULTADOS: A análise dos resultados apontou como dificuldades aquelas relacionadas ao espaço físico, materiais e equipamentos e à assistência de enfermagem específica ao paciente obeso mórbido. CONCLUSÃO: O conhecimento específico, a especialização e a experiência em Centro Cirúrgico darão o conforto, a segurança física e emocional necessárias a estes pacientes.OBJETIVO: Identificar las dificultades de enfermeros de centro quirúrgico en el cuidado a pacientes obesos mórbidos sometidos a cirugía bariátrica en el período transoperatorio. MÉTODOS: La muestra constó de 70 enfermeros con experiencia en asistencia al paciente obeso mórbido. Los datos fueron recolectados por medio de un cuestionario durante el 7º Congreso Brasileño de Enfermeros de Centro Quirúrgico, Recuperación Anestésica y Centro de Material y Esterilización. RESULTADOS: El análisis de los resultados identificó como dificultades aquellas relacionadas al espacio físico, materiales y equipos y a la asistencia de enfermería específica al paciente obeso mórbido. CONCLUSIÓN: El conocimiento específico, la especialización y la experiencia en Centro Quirúrgico darán el confort, la seguridad física y emocional que necesitan estos pacientes.OBJECTIVE: To identify the challenges for nurses during the perioperative for patients undergoing bariatric surgery. METHODS: The sample consisted of 70 nurses who had experience in providing care for morbid obese patients. Data were collected

  4. Conjunto de Ejercicios Físico con fines Terapéuticos para los pacientes obesos perteneciente al Consejo Popular Pueblo Nuevo del municipio de Consolación del Sur

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    Rainel Gómez Hernández

    2009-06-01

    Full Text Available En el presente   trabajo investigativo titulado: Conjunto de Ejercicios Físico con fines Terapéuticos para los pacientes obesos perteneciente al Consejo Popular Pueblo Nuevo del municipio de Consolación del Sur. La obesidad  constituye una de las enfermedades con  mayor  prevalecía     en los países occidentales, considerándose en la actualidad la enfermedad metabólica más frecuente. Puede considerarse un problema de salud pública, pues ocasiona una disminución de la esperanza de vida y constituye la segunda causa de mortalidad prevenible,  dado el tema surge la siguiente interrogante ¿Como contribuir al mejoramiento del Estado de Salud de los pacientes obesos perteneciente al Consejo Popular Pueblo Nuevo del municipio de Consolación del Sur? Esta investigación tiene como objetivo: Integrar  un Conjunto de Ejercicios Físicos con fines Terapéuticos para el mejoramiento del  Estado de Salud de los pacientes obesos perteneciente al Consejo Popular Pueblo Nuevo del municipio mencionado. Este trabajo propone un programa de ejercicios físicos para la disminución del peso corporal en los pacientes  que  presenta       obesidad que conviven en  el  Consejo Popular anteriormente mencionado. Para la realización del mismo se tuvo en cuenta fundamentalmente el método dialéctico–materialista de cual se derivan   los métodos teóricos y métodos empíricos, en los primeros podemos encontrar el Análisis-Síntesis, Histórico-Lógico y El Trabajo con Documentos y en los segundos la Encuesta, la Observación, para a través de los mismos recopilar datos que contribuyan  en el desarrollo satisfactorio de la investigación. La investigación es ubicada dentro de las ciencias biológicas vinculadas con el Deporte y la Cultura Física.  En la misma se resume los datos más importantes sobre ejercicios que contemplan  técnicas tradicionales  y  de  técnicas  orientales como

  5. 7th to 9th grade obese adolescents’ perceptions about obesity in tamaulipas, Mexico Percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado residentes en Tamaulipas, México Percepções da obesidade de adolescentes obesos, estudantes do 7º ao 9º grau residentes em Tamaulipas, México

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    Ma. de la Luz Martínez-Aguilar

    2010-02-01

    Full Text Available The objective was to explore obese adolescents’ perceptions about obesity among students in the seventh to ninth grade of a public school in Tamaulipas, Mexico. This is a qualitative study. Participants were 24 adolescents with a body mass index equal to or greater than the 95th percentile. Semistructured interviews were conducted until data saturation was reached and the meaning was understood. The adolescents defined obesity according to standards of measurement. They identified the hereditary factor as the main obesity cause, tended to underestimate obesity and had low self-esteem. They reported problems to do physical exercise and get clothes in order to improve their image, and feel rejected by their peers in school. It was identified that these adolescents have psychological defense mechanisms against obesity and that some of them are making efforts to lose weight. Obesity entails social and psychological health implications for persons suffering from this problem. Interventions should be put in practice.El objetivo de esta investigación fue explorar las percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado de una institución pública en Tamaulipas, México. Se trata de un estudio cualitativo en el cual participaron 24 adolescentes que tenían un índice de masa corporal superior al percentil 95. Se realizaron entrevistas semiestructuradas hasta obtener la saturación de los datos y la comprensión del significado. Los adolescentes definieron la obesidad de acuerdo a los estándares de medición, identificaron como causa principal el factor hereditario, tendieron a subestimar la obesidad y presentaron baja autoestima, relataron problemas cuando realizan actividad física y para conseguir ropa que pudiese mejorar su imagen, y se sienten rechazados por sus pares o iguales en la escuela. Se identificó que cuentan con mecanismos psicológicos de defensa ante la obesidad y algunos de ellos están realizando

  6. Prevalencia y factores asociados al síndrome metabólico en niños y adolescentes obesos del municipio Marianao Prevalence and factors associated with metabolic syndrome in obese children and adolescents from Marianao municipality

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    Johandra Argote Parolis

    2008-12-01

    Full Text Available ANTECEDENTES: la obesidad y el síndrome metabólico constituyen un problema creciente de salud infantil a nivel mundial. OBJETIVO: determinar la prevalencia y factores asociados al síndrome metabólico en niños y adolescentes obesos del municipio Marianao. MÉTODOS: se evaluaron 460 estudiantes entre 8 y 15 años de edad. Se aplicó cuestionario que incluyó variables como: edad, sexo, color de la piel, antecedentes patológicos personales y familiares, peso, talla, tensión arterial (3 tomas e índice cintura-cadera, y se realizó prueba de tolerancia a la glucosa oral (0 y 2 h para medir glucemia e insulinemia, lipidograma y ácido úrico. Se consideró la presencia de síndrome metabólico teniendo en cuenta los criterios según propuesta cubana. Se obtuvieron distribuciones de frecuencia de las variables cualitativas y media, y desviación estándar de las cuantitativas. Se utilizó el paquete estadístico SPSS. RESULTADOS: la frecuencia de obesidad fue de 15 %, de ellos el 66 % presentó obesidad severa. La prevalencia de síndrome metabólico entre los obesos fue de 21,7 %, con elevada frecuencia entre 10 y 12 años, y no se observó en negros. Predominó el índice cintura-cadera >90 percentil sobre los demás criterios. La presencia de síndrome metabólico y la insulinorresistencia aumentaron con la severidad de la obesidad. Los antecedentes patológicos personales y familiares no mostraron relación con la presencia de síndrome metabólico, ni con el bajo peso al nacer, como tampoco con los índices de insulinorresistencia. CONCLUSIONES: la prevalencia de síndrome metabólico es notable, y se asocia a factores como la edad, el color de la piel y la severidad de la obesidad. El índice cintura-cadera presenta gran impacto sobre el síndrome metabólicoBACkgROUNDS: obesity and metabolic syndrome are an increasing problem of infantile health at world level. OBJETIVE: to determine prevalence and factors associated to metabolic

  7. What's Mono?

    Science.gov (United States)

    ... mono? Have you ever heard of the "kissing disease"? If you said that it's mono, you're absolutely correct. But you don't get mono only from kissing. Infectious mononucleosis, called mono for short, is caused by the Epstein-Barr virus (EBV), which is a type of herpes ...

  8. Resistencia a insulina en adolescentes obesos

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    Maria Isabel Rojas-Gabulli

    2010-03-01

    Full Text Available Introducción: La obesidad en niños y adolescentes es un problema de salud pública que se encuentra en incremento a nivel mundial, siendo conocida su relación con el desarrollo de alteraciones metabólicas como la diabetes mellitus tipo 2. Objetivos: Determinar la presencia de resistencia a la insulina en adolescentes obesos y no obesos según sexo, edad, estadio puberal y antecedentes familiares de alteración metabólica o enfermedad cardiovascular (ECV explorando asociación y riesgo. Diseño: Estudio transversal, observacional y analítico. Lugar: Tres centros educativos de la zona urbana de Lima. Participantes: Adolescentes entre 10 y 17 años de edad. Intervenciones: Se estudió 69 adolescentes entre 10 y 17 años de edad, agrupados de acuerdo a la presencia de obesidad. El diagnóstico de obesidad fue definido por un índice de masa corporal (IMC >95 percentil; 55,1% varones y 44,9% mujeres. Se empleó el modelo de evaluación homeostática para determinar la resistencia a insulina (HOMA-IR y la función de la célula beta (HOMA-%B en ambos grupos. También se realizó determinaciones de lípidos mediante método enzimático y se aplicó una encuesta para buscar antecedentes familiares de obesidad, diabetes mellitus y enfermedad cardiovascular (ECV. El análisis estadístico se hizo mediante pruebas de correlación de Spearman y de comparación de medias con la prueba U de Mann- Whitney. Principales medidas de resultados: Insulina basal, colesterol total, triglicéridos, colesterol-VLDL, HOMA IR y HOMA%B en adolescentes obesos y no obesos. Resultados: Se encontró que la insulina basal, el colesterol total, triglicéridos, colesterol-VLDL, HOMA IR y HOMA%B fueron significativamente mayores (p<0,05 en el grupo de obesos. El HOMA-IR presentó una correlación inversa, débil, con el desarrollo puberal, particularmente en el sexo femenino (r=-0,486, p<0,05. Predominaron los antecedentes familiares de obesidad y ECV en el grupo de obesos

  9. Escala de VO2pico em adolescentes obesos e não-Obesos por diferentes métodos Escala de VO2pico en adolescentes obesos y no obesos por diferentes métodos Scale of VO2peak in obese and non-obese adolescents by different methods

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    Gerusa Eisfeld Milano

    2009-12-01

    estrategia atractiva para comparar individuos con grandes diferencias en la masa corporal. OBJETIVO: Investigar el VO2pico en individuos obesos y no obesos usando el método de corrección de masa corporal (convencional y la escala alométrica (método alométrico y cómo esos métodos se aplican cuando individuos de ambos sexos se ejercitan en una cinta ergométrica. MÉTODOS: El VO2pico relativo al peso corporal y por el método alométrico fue comparado en 54 adolescentes obesos y 33 no obesos (10-16 años. Para evaluar el VO2pico durante un test máximo se utilizó calorimetría indirecta. El exponente alométrico fue calculado considerando la masa corporal individual. Así, el VO2pico fue corregido mediante el exponente alométrico. Las comparaciones se realizaron utilizando two-way ANOVA para medidas repetidas (p0,05. Sin embargo, el VO2pico calculado por el método convencional fue mayor (p0.05 entre los grupos. CONCLUSIÓN: Los individuos obesos presentaron VO2pico más bajo que los no obesos, al ser evaluados mediante el método convencional. Sin embargo, las diferencias desaparecieron cuando se aplicó el método de la escala alométrica.BACKGROUND: Peak oxygen uptake (VO2peak can be defined as the highest oxygen rate consumed during exhaustive or maximal exercise. The evaluation of the aerobic fitness can be expressed as relative to body mass, but this procedure may not fully remove differences when heavy subjects are assessed. Thus, the allometric scaling procedure is an attractive strategy to compare individuals with large differences in body mass. OBJECTIVE: Investigate VO2peak in obese and non-obese individuals using body mass correction (conventional and allometric scaling (allometric methods and how these methods apply when subjects of different genders exercise on a treadmill. METHODS: VO2peak relative to body weight and measured by the allometric method were compared in 54 obese and 33 non-obese adolescents (10 a 16 years. Indirect calorimetry was used to

  10. Experimental investigation of heat transfer potential of Al2O3/Water-Mono Ethylene Glycol nanofluids as a car radiator coolant

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    Dattatraya G. Subhedar

    2018-03-01

    Full Text Available In this research, the heat transfer potential of Al2O3/Water-Mono Ethylene Glycol nanofluids is investigated experimentally as a coolant for car radiators. The base fluid was the mixture of water and mono ethylene glycol with 50:50 proportions by volume. The stable nanofluids obtained by ultra-sonication are used in all experiments. In this study nanoparticle volume fraction, coolant flow rate, inlet temperature used in the ranges of 0.2–0.8%, 4–9 l per minute and 65–85 °C. The results show that the heat transfer performance of radiator is enhanced by using nanofluids compared to conventional coolant. Nanofluid with lowest 0.2% volume fraction 30% rise in heat transfer is observed. Also the estimation of reduction in frontal area of radiator if base fluid is replaced by Nanofluid is done which will make lighter cooling system, produce less drag and save the fuel cost.

  11. Aspectos socioeconómicos y familiares asociados en niños y adolescentes obesos

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    William José González Cabriles

    2013-01-01

    Full Text Available El estudio es transversal y correlacional donde se analizaron las variables socioeconómicas y familiares de una muestra no probabilística, constituida por 528 familias de niños con obesidad exógena, de 2 a 18 años, provenientes de diversos sectores del país, atendidos en la consulta de primera del Centro de Atención Nutricional Infantil Antímano. El objetivo fue determinar los aspectos socioeconómicos y familiares asociados en niños y adolescentes con obesidad que asistieron al Centro. Los datos se procesaron con el programa SPSS 9.0. Se analizaron las distribuciones de frecuencias y el estadístico Chi-cuadrado para probar asociación entre las variables. El nivel de significancia fue 95%. En las familias de niños obesos se encontró que la mayoría de los jefes de familia eran obesos; las familias con pobreza extrema y la población infantil mayor de 15 años presentaron mayor sedentarismo; por último, las madres en general no participaron en la toma de decisiones en la compra de alimentos y no poseían nociones de alimentación equilibrada que les permitieran planificar la compra de alimentos. Estos aspectos se erigen como claves para ser abordados y resueltos por el trabajador social durante la intervención con el fin de favorecer la recuperación nutricional del niño obeso y su familia.

  12. How Is Mono Spread?

    Science.gov (United States)

    ... How Is Mono Spread? Print My sister has mononucleosis. I drank out of her drink before we ... that I have mono now? – Kyle* Mono, or mononucleosis, is spread through direct contact with saliva. This ...

  13. Effect of Grain Size on Mechanical Properties of Irradiated Mono- and Polycrystalline MgAl2O4

    International Nuclear Information System (INIS)

    Jagielski, J.; Piatkowska, A.; Wajler, A.; Boniecki, M.; Romaniec, M.; Jozwik, I.; Aubert, P.; Labdi, S.; Maciejak, O.; Thome, L.; Debelle, A.

    2011-01-01

    The influence of the size of crystalline regions on mechanical properties of irradiated oxides has been studied using a magnesium aluminate spinel MgAl 2 O 4 . The samples characterized by different dimensions of crystalline domains, varying from sintered ceramics with grains of few micrometers in size up to single crystals, were used in the experiments. The samples were irradiated at room temperature with 320 keV Ar 2+ ions up to fluences reaching 5x10 16 cm -2 . Nanomechanical properties (nanohardness and Young's modulus) were measured by using a nanoindentation technique and the resistance to crack formation by measurement of the total crack lengths made by the Vickers indenter. The results revealed several effects: correlation of nanohardness evolution with the level of accumulated damage, radiation-induced hardness increase in grain-boundary region and significant improvement of material resistance to crack formation. This last effect is especially surprising as the typical depth of cracks formed by Vickers indenter in unirradiated material exceeds several tens of micrometers, i.e. is more than hundred times larger than the thickness of the modified layer. (author)

  14. Estrés oxidativo, nitrosativo y daño cardiovascular en pacientes pediátricos obesos.

    OpenAIRE

    Tavárez Alonso, Sandra

    2015-01-01

    La obesidad predispone fuertemente al riesgo cardiovascular y se relaciona con alteraciones en diferentes marcadores de funcionalidad del tejido adiposo, inflamación y daño a biomoléculas. Establecer la presencia de alteraciones precoces en la obesidad infantil es el objetivo de este estudio realizado en pacientes pediátricos (7-14 años) obesos (N=60) y controles (N=42). En él hemos evaluado como marcadores de estrés oxidativo y nitrosativo los niveles de malondialdehído, 8-isoprostanos, pro...

  15. Il cavo orale nel paziente obeso

    OpenAIRE

    Faggella, Antonella

    2008-01-01

    Le condizioni di sovrappeso ed obesità anche in età evolutiva sono aumentate negli ultimi decenni al punto che, secondo l'Organizzazione Mondiale della Sanità, sono diventate un problema di salute pubblica in tutti i Paesi occidentali. Questa tesi è nata nell’obiettivo di individuare caratteristiche odontostomatologiche in pazienti affetti da obesità; il gruppo campione(80 pazienti, età media 10,5 anni) è stato suddiviso in due sottogruppi: sottogruppo A comprendente 54 pazienti affetti da...

  16. Adversidade na infância, características psicológicas e problemas de saúde física: comparação entre obesos e não obesos

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    Susana Sofia Pereira da Silva

    2011-01-01

    Full Text Available INTRODUÇÃO: A literatura é unânime sobre a elevada morbilidade e mortalidade associada à obesidade, mas pouco consistente no que se refere às características psicológicas dos obesos. OBJETIVO: O objetivo deste estudo é caracterizar as experiências de vida e os problemas de saúde física e mental de um grupo de obesos e compará-los com sujeitos não obesos. MÉTODO: Oitenta e um obesos e cem não obesos foram avaliados quanto às experiências adversas na infância, psicopatologia geral, dimensões de personalidade, estilos de coping e problemas e queixas de saúde. RESULTADOS: As experiências de abuso emocional e de negligência são frequentemente relatadas, mas algumas experiências de adversidade na infância são pouco relatadas pelos obesos e não obesos. Os obesos relatam mais queixas, problemas de saúde física e menos coping, mas os não obesos apresentam valores médios de psicopatologia superiores. Nas dimensões de personalidade, não se verifica qualquer diferença entre os grupos. A psicopatologia geral, as estratégias de coping, as queixas de saúde e os problemas de saúde distinguem obesos de não obesos. CONCLUSÃO: Contrariamente ao que sugerem alguns estudos, os obesos não relatam mais adversidade e relatam menos psicopatologia geral do que os não obesos. No entanto, apresentam mais queixas e problemas de saúde e usam estratégias de coping de forma diferente.

  17. Ecocardiograma e fatores de risco cardiovascular em obesos graves

    OpenAIRE

    Elaine Gonçalves Moreira Rocha, Isaura

    2003-01-01

    Introducão: Alterações em parâmetros hemodinâmicos e na função cardíaca ocorrem na obesidade grave, em associação a outros fatores de risco cardiovascular, como dislipidemia, hipertensão arterial e diabete melito. Material e métodos: Foi descrito o perfil clínico, metabólico, ecocardiográfico e o risco de doença cardiovascular, avaliado através do escore de Framingham, em 32 obesos graves candidatos à gastroplastia, no Hospital das Clínicas da Universidade Federal de Pernambuco, entre jane...

  18. Diferencias clínicas y polisomnográficas entre obesos y no obesos con síndrome de apneas-hipopneas del sueño Clinical and polysomnographyc differences between obese and non obese patients with obstructive sleep apnea-hypopnea syndrome

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    Jorge Rey de Castro

    2011-12-01

    Full Text Available Objetivos. Describir las diferencias clínicas y polisomnográficas en pacientes obesos y no obesos con diagnóstico del síndrome de apneas-hipopneas del sueño (SAHS. Materiales y métodos. A los pacientes incluidos se les realizó un examen físico, se aplicó la escala de somnolencia de Epworth (ESE y además se les realizó una polisomnografía. Se consideró obeso si el índice de masa corporal (IMC era mayor o igual a 30 kg/m2. Resultados. Se analizaron 408 pacientes con SAHS, de estos, 119 (47 % fueron obesos. El SAHS fue leve en 101 (25 %, moderado en 91 (22 % y severo en 216 (53 %. No hubo diferencias por sexo, edad y puntaje ESE al compararse obesos con no obesos. La diferencias del perímetro cervical y presencia de somnolencia según ESE fue significativamente mayor en obesos. Estos tuvieron mayor comorbilidad en términos de dislipidemia, hipertensión arterial y enfermedad coronaria. De las variables polisomnográficas, los índices de eventos respiratorios fueron mayores en obesos, asimismo fueron peores los valores de saturación de oxígeno. No hubo diferencias en el resto de variables. El análisis de regresión mostró asociación entre la obesidad y la severidad del SAHS. Conclusiones. El SAHS no es una enfermedad limitada a la población obesa, aunque esta última tienen mayor comorbilidad y formas más severas de enfermedad.Objectives. To describe the clinical and polysomnographyc differences between obese and non- obese patients with obstructive sleep apnea-hypopnea (OSAH syndrome. Materials and methods. A physical examination, the Epworth Sleepiness Scale (ESS and a polysomnography were performed to all included patients. Obesity was defined as a body mass index (BMI of ≥ 30 kg/m2. Results. 408 patients with OSAH were analyzed, out of these, 119 (47 % were obese. OSAH was mild in 101 (25 %, moderate in 91 (22 % and severe in 216 (53 %. There were no age, sex and EES score differences between obese and non

  19. Efeitos de diferentes graus de sensibilidade a insulina na função endotelial de pacientes obesos

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    Roberto Galvão

    2012-01-01

    Full Text Available FUNDAMENTO: A obesidade derivada da deposição de gordura intra-abdominal tende a aumentar a produção de hormônios e citoquinas, piorando a sensibilidade a insulina e levando a disfunção endotelial. A hiperinsulinemia é considerada um fator de risco independente para doença isquêmica cardíaca e é uma causa de disfunção endotelial em indivíduos saudáveis. OBJETIVO: Avaliar o impacto de diferentes graus de resistência a insulina, medida pelo HOMA-IR (Homeostasis Model Assessment of Insulin Resistance, sobre a função endotelial de obesos, pacientes não diabéticos, sem história prévia de eventos cardiovasculares e diversos componentes da síndrome metabólica. MÉTODOS: Um total de 40 indivíduos obesos foi submetido a medidas antropométricas, pressão arterial de consultório, MAPA e exames laboratoriais, além de avaliação ultrassonográfica não invasiva da função endotelial. Os pacientes foram divididos em três grupos de acordo com o grau de resistência a insulina: pacientes com valores de HOMA-IR entre 0,590 e 1,082 foram incluídos no Grupo 1 (n = 13; entre 1,083 e 1,410 no Grupo 2 (n = 14; e entre 1,610 e 2,510 no Grupo 3 (n = 13. RESULTADOS: Encontramos uma diferença significativa na vasodilatação mediada por fluxo no Grupo 3 em relação ao Grupo 1 (9,2 ± 7,0 vs 18,0 ± 7,5 %, p = 0,006. Houve uma correlação negativa entre a função endotelial e insulina, HOMA-IR e triglicérides. CONCLUSÃO: Nosso estudo sugere que leves alterações nos níveis de resistência a insulina avaliada pelo HOMA-IR podem causar algum impacto sobre a função vasodilatadora do endotélio em indivíduos obesos não complicados com diferentes fatores de risco cardiovascular.

  20. Problemas clínicos pré-anestésicos de pacientes morbidamente obesos submetidos a cirurgias bariátricas: comparação com pacientes não obesos Problemas clínicos pré-anestésicos de pacientes mórbidamente obesos sometidos a cirugías bariátricas: comparación con pacientes no obesos Preanesthetic clinical problems of morbidly obese patients submitted to bariatric surgery: comparison with non-obese patiens

    Directory of Open Access Journals (Sweden)

    Getúlio Rodrigues de Oliveira Filho

    2002-04-01

    átricas, imponiendo nuevos desafíos al anestesiólogo. Este estudio comparó la prevalencia de problemas clínicos entre pacientes mórbidamente obesos sometidos a cirugías bariátricas y no obesos sometidos a otros procedimientos electivos. MÉTODO: Fueron estudiados, retrospectivamente, los registros electrónicos de 2986 pacientes divididos en grupo 1, obesos mórbidos sometidos a cirugías bariátricas y grupo 2, con índice de masa corporal menor que 30, sometidos a otros procedimientos electivos, relacionados al grupo 1 por la edad, sexo y estado físico (ASA. Los problemas pré-anestésicos del grupo 1 fueron pesquisados en el grupo 2 y las prevalencias comparadas. Las razones de chance (RC y respectivos limites de 95% de confianza (LC 95% fueron calculados. RESULTADOS: Los problemas identificados nos grupos 1 y 2 y sus respectivas prevalencias fueron: reflujo gastroesofágico (16,67% y 0,48%, hipertensión arterial sistémica (50% y 3,06%, diabetes mellitus tipo II (6,25% y 0,31%, hipotiroidismo (6,25% y 0,31%, asma bronquica (10,42% y 1,43% y pneumopatia restrictiva (10,42% y 0,03%. Las prevalencias fueron significativamente mas altas en el grupo 1. Fueron también identificados, en el grupo 1, los siguientes problemas que no fueron encontrados en el grupo 2: epilepsia (2,08%, esteatosis hepática (12,5%, colecistopatia calculosa (6,25%, dislipidemia (20,83% e hipopituitarismo (2,08%. CONCLUSIONES: La prevalencia de problemas clínicos es significativamente mas alta en pacientes portadores de obesidad mórbida de que en no obesos de la misma edad, sexo y estado físico.BACKGROUND AND OBJECTIVES: Morbid obesity is associated to clinical problems responsible for decreased life expectancy. Morbidly obese patients are candidates to gastric bypass and pose new challenges to the anesthesiologist. This study compared the prevalence of clinical problems among morbidly obese patients submitted to bariatric surgery to non-obese patients submitted to other elective surgical

  1. Estudo transversal sobre problemas bucais em pacientes obesos mórbidos

    OpenAIRE

    Joselene Martinelli Yamashita

    2013-01-01

    A prevalência da obesidade tem aumentado em proporções alarmantes, tornando-se um problema de saúde pública. Há relatos de uma possível relação da obesidade com a condição bucal e o objetivo do presente estudo foi identificar os problemas bucais e seu impacto na qualidade de vida de indivíduos obesos mórbidos. A amostra foi composta por 100 pacientes obesos mórbidos (grupo obeso) e 50 indivíduos eutróficos (grupo controle), atendidos no Hospital das Clínicas da Faculdade de Medicina de Ribeir...

  2. How Long Is Mono Contagious?

    Science.gov (United States)

    ... Here's how it works: Mono is short for mononucleosis . It's usually caused by an infection with the ... May 2018 More on this topic for: Teens Mononucleosis How Do Doctors Test for Mono? Can a ...

  3. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2

    Directory of Open Access Journals (Sweden)

    Cabrera-Pivaral Carlos Enrique

    2004-01-01

    Full Text Available La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos de pacientes diabéticos obesos. La intervención educativa-participativa se organizó mediante el proceso de reflexión-acción. Se efectuaron mediciones del IMC basal y mensuales durante los 9 meses de la intervención educativa. Los grupos fueron controlados tomando en cuenta edad y sexo. El análisis estadístico se efectuó con el estadígrafo de t de students con diferencia de media para grupos relacionados. El grupo control logra un valor promedio de IMC basal de 33.89 ± 1.96 y al final de 33.2 ± 2.15 (t: 22.4; p: 0.16, el grupo de experimento con valor inicial de 33.63 ± 2.12 y final de 31.54 ± 1.71 (t: 11.55; p = 0.003. La intervención educativa participativa contribuye a mejorar el nivel de IMC en los diabéticos obesos 2.

  4. Vias aéreas e conteúdo gástrico no paciente obeso

    OpenAIRE

    Reis, Leonardo de Andrade; Reis, Guilherme Frederico Ferreira dos; Oliveira, Milton Roberto Marchi de

    2010-01-01

    JUSTIFICATIVA E OBJETIVOS: O presente artigo teve como objetivo rever as referências bibliográficas e questionar o conceito de que o obeso deve ser considerado de estômago cheio, questionando, consequentemente, a forma como a via aérea deve ser abordada na indução da anestesia geral, considerada de difícil acesso devido à obesidade. CONTEÚDO: Classicamente, o paciente obeso é considerado de estômago cheio, levando a condutas protetoras das vias aéreas durante a indução da anestesia geral. Fre...

  5. Relação de amizade de adolescentes obesos e eutróficos

    Directory of Open Access Journals (Sweden)

    Teresa Helena Schoen-Ferreira

    2010-04-01

    Full Text Available Na adolescência, ampliam-se os horizontes sociais. Muitos obesos têm uma autoimagem crítica e tornam-se mais isolados. Objetivo: verificar o grau de intimidade nos relacionamentos entre pares de adolescentes obesos, comparando-os a eutróficos. Método: participaram 160 adolescentes, sendo 80 obesos (IMC > 95, grupo estudo. Instrumento: foi usado o friendship questionarie, que caracteriza o interesse, intimidade e integração com amigos. Procedimentos: o grupo estudo respondeu ao instrumento em um ambulatório para adolescentes e o grupo controle em uma escola. Resultados: não houve diferença estatística significante (p=0,412 entre o escore médio do GE (80,08 e GC (81,99. Entre os obesos, não houve diferença estatística (p=0,220 entre o sexo masculino (x =82,83 e o feminino (x =78,51; entre os eutróficos, as moças (x=84,88 tiveram uma média significativamente maior (p=0,016 que os rapazes (x =76,90. Conclusão: não houve diferenças em relação ao grau de intimidade com os pares entre adolescentes obesos e eutróficos. Ambos os grupos estudados procuram investir em uma amizade mais íntima e forte. A obesidade parece afetar menos os relacionamentos sociais dos adolescentes masculinos.

  6. Vias aéreas e conteúdo gástrico no paciente obeso Vías aéreas y contenido gástrico en el paciente obeso The airways and gastric contents in obese patients

    Directory of Open Access Journals (Sweden)

    Leonardo de Andrade Reis

    2010-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O presente artigo teve como objetivo rever as referências bibliográficas e questionar o conceito de que o obeso deve ser considerado de estômago cheio, questionando, consequentemente, a forma como a via aérea deve ser abordada na indução da anestesia geral, considerada de difícil acesso devido à obesidade. CONTEÚDO: Classicamente, o paciente obeso é considerado de estômago cheio, levando a condutas protetoras das vias aéreas durante a indução da anestesia geral. Frequentemente, são realizadas intubações com o paciente acordado ou intubação de sequência rápida. Porém tal conceito baseia-se em um único trabalho da literatura, citado por diversos outros autores. O obeso também é considerado difícil de intubar, criando receio a respeito do sucesso da abordagem da via aérea. Os trabalhos da literatura, entretanto, contestam tais conceitos, o que leva ao questionamento das técnicas de acesso às vias aéreas. CONCLUSÕES: Os trabalhos da literatura mostram que o esvaziamento gástrico no obeso não é lentificado como se acreditava, assim como o conteúdo gástrico não é maior que no paciente não obeso; portanto, a intubação em plano anestésico pode ser realizada com segurança. Apesar de a obesidade, isoladamente, não causar falha na intubação, outros sinais podem ser usados para prever intubação difícil.JUSTIFICATIVA Y OBJETIVOS: El presente artículo tuvo el objetivo de analizar nuevamente las referencias bibliográficas y de cuestionar el concepto de que el obeso debe ser considerado como de estómago lleno, cuestionando, por tanto, la forma como la vía aérea debe ser abordada en la inducción de la anestesia general considerada de difícil acceso a causa de la obesidad. CONTENIDO: Clásicamente, al paciente obeso se le considera como de estómago lleno, conllevando a conductas protectoras de las vías aéreas durante la inducción de la anestesia general. A menudo se realizan

  7. Inversor elevador mono - etapa

    OpenAIRE

    Herber Ramírez, Juan José De Jesús

    2006-01-01

    En este trabajo de tesis se estudia una topología Mono - Etapa de un Inversor Elevador. Esta estructura está formada por dos convertidores CD - CD Elevadores bidireccionales en corriente, los cuales son controlados por dos señales senoidales, con cierto nivel de CD, desfasadas 180º. Las principales ventajas que esta topología presenta son: 1) Este Inversor genera de manera natural, mediante el control adecuado, un voltaje CA de salida mayor que el voltaje de CD de entrada ...

  8. Considerações acerca da avaliação psicológica das comorbidades psiquiátricas em obesos Consideraciones sobre la evaluación psicológica de las comorbidades psiquiátricas en obesos Consideration about psychological assessment of psychiatric co morbidity in obese

    Directory of Open Access Journals (Sweden)

    Fabiana Silva Costa

    2009-06-01

    Full Text Available Pretende-se neste artigo apresentar uma revisão teórica sobre avaliação psicológica, obesidade e comorbidades psiquiátricas mais frequentes na população obesa. A obesidade é uma doença clínica de múltiplas causas, e atualmente é considerada uma epidemia; assim seu adequado entendimento deve envolver uma equipe composta por diversos profissionais de saúde, incluindo o psicólogo. Serão abordadas questões pertinentes ao tema de obesidade, como etiologia, incidência e a relação entre obesidade e transtornos psiquiátricos. Serão propostos alguns instrumentos com o objetivo de estruturar informações necessárias ao tratamento e à demanda do paciente obeso, e reflexões referentes à avaliação psicológica em obesos e a prática do profissional de psicologia.Se pretiende en ese artículo presentar una revisión teórica sobre la evaluación psicológica, obesidad y comorbidades psiquiátricas más frecuentes en esa población. La obesidad es una enfermedad clínica con diversas causas y actualmente es considerada una epidemia, así el adecuado entendimiento de la obesidad debe involucrar un equipo compuesto por diversos profesionales de salud, incluso el psicólogo. En ese artículo serán abordadas cuestiones pertinentes a la temática de la obesidad, como etiología, prevalencia y la relación entre obesidad y los trastornos psiquiátricos. Serán propuestos algunos instrumentos* con el objetivo de estructurar informaciones necesarias al tratamiento y a la demanda del paciente obeso, reflexiones referentes a la evaluación psicológica en obesos y la práctica del profesional de PsicologíaWe intend in this article to present a theoretical review about psychological assessment, obesity and psychiatric co morbidity. Obesity is a clinical illness, it has multi factorial causes, and nowadays it is considered an epidemic, so the right knowledge must involve all health professional, include the psychologist. In this article we

  9. Manobra de recrutamento alveolar e suporte ventilatorio perioperatorio em pacientes obesos submetidos a cirurgia abdominal

    Directory of Open Access Journals (Sweden)

    Luiz Alberto Forgiarini Junior

    2013-12-01

    Full Text Available O desenvolvimento da cirurgia abdominal proporcionou uma alternativa terapêutica para obesos mórbidos; entretanto, os pacientes submetidos a esse procedimento frequentemente apresentam complicações pulmonares pós-operatórias. Uma possível alternativa para a redução dessas complicações é a utilização da manobra de recrutamento alveolar e/ou estratégias ventilatórias perioperatórias, com foco na redução das complicações pulmonares pós-operatórias. Nesta revisão, são descritos os benefícios de estratégias ventilatórias perioperatórias, assim como a realização de manobra de recrutamento alveolar em pacientes obesos submetidos a cirurgia abdominal.

  10. Atuação ambulatorial do profissional de educação física no atendimento a crianças e adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Perino Barbosa

    1999-02-01

    Full Text Available A freqüência da obesidade na infância e adolescência aumentou nos últimos anos. Essa situação tem preocupado a área da saúde, não só pelas conseqüências promovidas pela obesidade na população em geral, mas pela imposição de prejuízos biopsicossociais, ainda na infância. O tratamento é bastante complexo, pois sua causa é multifatorial, exigindo atenção interdisciplinar. O presente trabalho teve como objetivo relatar o papel do professor de educação física na equipe de atendimento ambulatorial de crianças e adolescentes obesos. A atividade física, depois da taxa metabólica basal, é considerada o segundo maior componente do gasto energético diário. Diversos estudos demonstraram que a atividade física associada ao controle alimentar leva a melhores resultados do que essas ações isoladas. O aumento da atividade física é muito benéfico no tratamento de crianças e adolescentes obesos, pois permite maior ingestão alimentar e auxilia a preservar a massa magra. Entretanto, o exercício físico deve ser adaptado às condições de excesso de peso e de crescimento ósseo. Além desses cuidados, o profissional depara-se com a dificuldade de manter crianças e adolescentes em programa de exercício regular. Desse modo, a prescrição do aumento de movimento corporal após a anamnese da rotina diária de cada paciente foi a solução encontrada para, inicialmente, colocá-los em contato com o próprio corpo. Paralelamente, o professor de educação física auxilia a criança a encontrar um tipo de esporte que mais lhe agrade, dentro daqueles permitidos pelo seu excesso de peso e fase de crescimento. Geralmente, recomendam-se atividades que tenham baixo impacto, como nadar, caminhar e andar de bicicleta. O professor de educação física, como educador, deve fazer parte do atendimento multidisciplinar de crianças e adolescentes obesos.

  11. Método do limiar de variabilidade da frequência cardíaca aplicado em pré-adolescentes obesos e não obesos

    Directory of Open Access Journals (Sweden)

    Mário Augusto Paschoal

    2011-06-01

    Full Text Available FUNDAMENTO: A detecção do limiar anaeróbico (LA pela análise da variabilidade da frequência cardíaca (LiVFC pode significar uma nova maneira de avaliação da capacidade funcional cardiorrespiratória (CFCR em pré-adolescentes. OBJETIVO: Testar o método de LiVFC para detecção do LA em pré-adolescentes não obesos (NO, obesos (O e obesos mórbidas (OM, a fim de determinar diferenças em sua CFCR. MÉTODOS: Foram estudados 30 pré-adolescentes, com idades entre 9 e 11 anos, divididos em três grupos de 10: a grupo NO - índice de massa corpórea (IMC com percentil do National Center for Chronic Disease Prevention and Health Promotion entre 5 e 85; b grupo O - IMC de percentil entre 95 e 97 e c grupo OM - IMC com percentil acima de 97. Todos foram submetidos a um protocolo incremental realizado em esteira rolante e registraram-se os batimentos cardíacos para detecção do LiVFC, que foi determinado pelo valor de 3,0 ms do índice do desvio-padrão 1 (SD1, extraído dos intervalos RR. RESULTADOS: Os valores médios no momento do LiVFC mostraram maiores valores para o grupo NO, destacando-se: a VO2 (ml/kg/min NO = 27,4 ± 9,2; O = 13,1 ± 7,6 e OM = 11,0 ± 1,7; b FC (bpm: NO = 156,3 ± 18,0; O =141,7 ± 11,4 e OM = 137,7 ± 10,4; e c distância percorrida (metros: NO = 1.194,9 ± 427,7; O = 503,2 ± 437,5 e OM = 399,9 ± 185,1. CONCLUSÃO: O LiVFC se mostrou efetivo para avaliação da CFCR e poderá vir a ser aplicado como método alternativo à ergoespirometria em determinadas situações.

  12. Well-defined mono(η3-allyl)nickel complex MONi(η3-C3H5) (M = Si or Al) grafted onto silica or alumina: A molecularly dispersed nickel precursor for syntheses of supported small size nickel nanoparticles

    KAUST Repository

    Li, Lidong; Abou-Hamad, Edy; Anjum, Dalaver H.; Zhou, Lu; Laveille, Paco; Emsley, Lyndon; Basset, Jean-Marie

    2014-01-01

    Preparing evenly-dispersed small size nickel nanoparticles over inert oxides remains a challenge today. In this context, a versatile method to prepare supported small size nickel nanoparticles (ca. 1-3 nm) with narrow size distribution via a surface organometallic chemistry (SOMC) route is described. The grafted mono(η3-allyl)nickel complexes MONi(η 3-C3H5) (M = Si or Al) as precursors are synthesized and fully characterized by elemental analysis, FTIR spectroscopy and paramagnetic solid-state NMR. © 2014 the Partner Organisations.

  13. Mono pile foundation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lyngesen, S.; Brendstrup, C.

    1997-02-01

    The use of mono piles as foundations for maritime structures has been developed during the last decades. The installation requirements within the offshore sector have resulted in equipment enabling driving of piles up to 3-4 m to large penetration depths. The availability of this equipment has made the use of large mono piles feasible as foundations for structures like wind turbines. The mono pile foundations consists of three parts; the bare pile, a conical transition and a boat landing. All parts are prefitted at the yard in order to minimise the installation work that has to be carried out offshore. The study of a mono pile foundations for a 1.5 MW wind turbine has been conducted for two locations, Horns Rev and Roedsand. Three different water depths: 5, 8 and 11 m have been investigated in the study. The on-site welding between pile and conical transition is performed by an automatic welding machine. Final testing and eventually repair of the weld are conducted at least 16 hours after welding. This is followed by final installation of J-tube, tie-in to subsea cables and installation of the impressed current system for corrosive protection of the mono pile. The total cost for procurement and installation of the mono pile using the welded connection is estimated. The price does not include procurement and installation of access platform and boat landing. These costs are estimated to 250.000 DKK. Depending on water depth the cost of the pile ranges from 2,2 to 2,7 million DKK. Procurement and fabrication of the pile are approx. 75% of the total costs. The remaining 25% are due to installation. The total costs are very sensitive to the unit price of pile steel. During the project it became obvious that ice load has a very large influence on the dimensions of the mono pile. (EG)

  14. Mecanismos de regulación del anabolismo lipídico en el tejido adiposo del paciente obeso

    OpenAIRE

    Ortega Delgado, Francisco José

    2012-01-01

    La obesidad es uno de los problemas de salud pública más importante. Los estudios de expresión aplicados a los depósitos de grasa en sujetos obesos han aportado importantes indicios sobre la fisiopatología del tejido adiposo. Los datos recogidos en esta tesis doctoral demuestran que la síntesis de grasa (lipogénesis) está disminuida en el tejido adiposo del paciente obeso, y describen el comportamiento de un nuevo factor lipogénicos. Se demuestra además que el tejido adiposo subcutáneo (situa...

  15. Síndrome metabólico en niños y adolescentes hipertensos obesos

    Directory of Open Access Journals (Sweden)

    Yudalvis Oquendo de la Cruz

    2010-12-01

    Full Text Available INTRODUCCIÓN. La combinación de hipertensión y obesidad en la infancia y la adolescencia incrementa el riesgo de un síndrome metabólico (SM en edades tempranas de la vida. El objetivo de este estudio fue determinar la presencia de SM en adolescentes hipertensos obesos y su relación con algunas variantes clínicas y bioquímicas. MÉTODOS. Se realizó un estudio descriptivo y prospectivo, con 152 niños y adolescentes hipertensos obesos, con edades entre 5 y 19 años, procedentes de la consulta de nefrología del Hospital Pediátrico Universitario «Juan Manuel Márquez». Se realizaron estudios de microalbuminuria, glucemia, insulina, colesterol total y triglicéridos en ayunas. RESULTADOS. Se encontró síndrome metabólico en el 35,5 % de los hipertensos obesos y fue más frecuente en el sexo masculino. Predominó la obesidad grave y 8 de cada 10 niños presentaron 3 criterios del síndrome. La prevalencia de cada uno de los componentes fue del 33,3 % en la alteración del metabolismo de la glucosa, del 100 % en la obesidad central e hipertensión arterial, del 51,8 % en la hipertrigliceridemia y del 13 % en el colesterol de lipoproteínas de alta densidad (HDL-C bajo. Casi la mitad de los pacientes tenían microalbuminuria. El 31,5 % de los sujetos estudiados presentó insulinorresistencia y en el 29,5 % de los casos se encontró hígado graso no alcohólico. CONCLUSIONES.Uno de cada 3 hipertensos obesos tenía síndrome metabólico, por lo que se recomienda continuar investigando sobre este síndrome en la infancia y la adolescencia.

  16. Programa de intervención mediante ejercicio físico en pacientes obesos

    OpenAIRE

    López Rodríguez, Christian

    2016-01-01

    Se ha demostrado que los problemas de mortalidad y morbilidad asociados a la obesidad se reducen drásticamente cuando se incrementan los niveles de actividad física (AF), y de este modo la obesidad puede que sea un predictor menos importante que la AF. En este sentido, se hace necesario la implementación de un método de entrenamiento que pueda ser tolerado, motivante y seguro, que desencadene notables mejoras en la calidad de vida en pacientes obesos. El entrenamiento interválico de alta inte...

  17. Acupuntura e apetite de trabalhadores obesos de um hospital universitário Acupuntura y apetito de trabajadores obesos de un hospital universitario Acupuncture and appetite in obese employees of a university hospital

    Directory of Open Access Journals (Sweden)

    Mariana Lourenço Haddad

    2011-01-01

    Full Text Available OBJETIVO: Mensurar o comportamento da sensação de apetite dos sujeitos antes, durante e após a intervenção de acupuntura. MÉTODOS: Estudo descritivo exploratório. A coleta de dados ocorreu em um hospital universitário em Maringá - PR, entre julho e outubro de 2009, com 37 trabalhadores obesos, que receberam oito sessões semanais de acupuntura. Para mensuração do apetite, foram utilizadas as Escalas Visuais Analógicas. RESULTADOS: Demonstraram que o comportamento do apetite em relação à saciedade, plenitude, desejo por alimentos doces e palatáveis sofreu modificações durante a intervenção. Não houve redução de peso ou índice de massa corpórea dos sujeitos, contudo observou-se redução significativa na razão cintura-quadril (p=0,02 e controle no hábito de consumir alimento consolo. CONCLUSÃO: Os achados do estudo podem contribuir para a formação do corpo de conhecimento da acupuntura voltada à saúde do trabalhador, sobretudo nos aspectos relacionados à obesidade, suas comorbidades e fatores desencadeantes.OBJETIVO: Mensurar el comportamiento de la sensación de apetito de los sujetos antes, durante y después de la intervención de acupuntura. MÉTODOS: se trata de un estudio descriptivo exploratorio. La recolección de datos se llevó a cabo en un hospital universitario en Maringá PR, entre julio y octubre del 2009, con 37 trabajadores obesos, que recibieron ocho sesiones semanales de acupuntura. Para la mensuración del apetito, fueron utilizadas las Escalas Visuales Analógicas. RESULTADOS: Demostraron que el comportamiento del apetito en relación a la saciedad, plenitud, deseo de alimentos dulces y agradables al paladar sufrió modificaciones durante la intervención. No hubo reducción de peso o índice de masa corporal de los sujetos, con todo se observó reducción significativa en la razón cintura-cadera (p=0,02 y control en el hábito de consumir alimento consuelo. CONCLUSIÓN: Los hallazgos del

  18. A percepção de saúde para adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Maria das Graças Carvalho Ferriani

    2000-12-01

    Full Text Available O presente estudo tem como objetivo conhecer a percepção de saúde para adolescentes obesos que participam do Programa Multidiciplinar de Assistência ao Adolescente Obeso, desenvolvido no Campus de Ribeirão Preto - USP. Foi utilizada a abordagem qualitativa fundamentada em Minayo (1996; os dados foram coletados através de frases e redações de 17 adolescentes integrantes do programa. A análise e interpretação dos dados foi ancorada na técnica de análise temática proposta por Bardin (1977, onde identificou-se os seguintes núcleos de sentido: saúde é beleza, alimentação e higiene e prática de esportes. Assim, o estudo evidenciou que a imagem corporal ideal que o adolescente busca para si, está relacionada com os padrões de beleza ditados pela mídia e com estereótipos de perfeição física. Outro aspecto detectado no estudo, é que os adolescentes têm consciência da importância de praticar esportes e ter uma alimentação balanceada.

  19. Festival nimega Mono / Ivar Sakk

    Index Scriptorium Estoniae

    Sakk, Ivar, 1962-

    2015-01-01

    Haapsalu graafilise disaini festival Haapsalu Linnagaleriis: sisaldab ülevaate- ja teemanäitust ning väikest sümpoosioni. Temaatilise aastanäituse motiiv on "MONO". Plakateid on ka välismaa tegijatelt. Kuraator Marko Kekishev

  20. EXPANSIÓN Y DIVERGENCIA DEL LOCUS GH ENTRE EL MONO ARAÑA Y EL CHIMPANCÉ

    OpenAIRE

    DE MENDOZA, AGNÈS; ESQUIVEL, DOLORES; MARTÍNEZ, IRMA; BARRERA, HUGO

    2005-01-01

    Para precisar la historia muy particular de la hormona del crecimiento (GH) en los primates, se describieron los loci GH del mono araña, un mono del Nuevo Mundo y del chimpancé, una especie cercana al humano. Al menos seis genes integran ambos loci GH: todos del tipo GH en el mono araña, y dos GHs y cuatro lactógenos placentarios (PLs) en el chimpancé. Las regiones intergénicas del locus del chimpancé presentan un tamaño mayor a las del mono araña. Este trabajo conf...

  1. Métodos de análise da composição corporal em adultos obesos

    Directory of Open Access Journals (Sweden)

    Rávila Graziany Machado de Souza

    2014-10-01

    Full Text Available Os métodos de avaliação da composição corporal em obesos têm sido amplamente discutidos, uma vez que nesses indivíduos a avaliação é dificultada devido às limitações dos equipamentos e características dos métodos utilizados. Esta sessão temática tem o objetivo de esclarecer as características, vantagens e limitações dos métodos de avaliação da composição corporal em adultos obesos. A quantificação de gordura corporal e mas-sa livre de gordura, assim como a avaliação da perda de massa muscular e de massa óssea em obesos são temas de grande interesse científico, uma vez que são utilizados para diagnosticar a obesidade osteosarcopênica. A avaliação da composição corporal de obesos pelo modelo de múltiplos compartimentos é padrão-ouro na prática científica. Por outro lado, o método de absorciometria radiológica de feixe duplo é considerado o padrão de referência em pesquisas e na prática clínica. Estudos indicam que a ressonância magnética e a tomografia computadorizada, em alguns casos, são fortemente correlacionadas com a absorciometria radiológica de feixe duplo. Os demais métodos apresentam limitações em avaliar a composição corporal, bem como suas modificações durante a redução ponderal em indivíduos obesos.

  2. Percepção do adolescente obeso sobre as repercussões da obesidade em sua saúde Percepción de los adolescentes obesos respecto de los efectos de la obesidad en su salud Obese adolescents' perceptions about the repercussions of obesity on their health

    Directory of Open Access Journals (Sweden)

    Solange Queiroga Serrano

    2010-03-01

    Full Text Available O objetivo deste estudo é avaliar a percepção do adolescente obeso sobre as repercussões da obesidade em sua saúde. Baseou-se no relato de quinze adolescentes obesos, acompanhados no Ambulatório do Hospital das Clínicas da Universidade Federal de Pernambuco, no período de abril a julho de 2007. Os depoimentos, obtidos através de entrevista semi-estruturada, foram submetidos à análise de conteúdo, modalidade temática transversal. Foram identificadas quatro temáticas relacionadas com os objetivos do estudo: 1. A percepção do conceito de obesidade; 2. A obesidade afetando a auto-imagem; 3. Obesidade versus Saúde e 4. O difícil retorno à saúde. Os adolescentes perceberam a obesidade como doença, repercutindo negativamente sobre sua saúde, apresentando uma baixa auto-estima e a sensação de isolamento. Reconhecem que ser saudável é ter uma alimentação correta e praticar atividade física, sendo imprescindível o apoio formal e informal, sobrepujando as dificuldades para manter uma qualidade de vida satisfatória.El objetivo de este estudio es evaluar la percepción del adolescente obeso respecto de los efectos de la obesidad en su salud. Se basó en el relato de quince adolescentes obesos que recibían seguimiento médico en el Ambulatorio del Hospital das Clínicas da Universidade Federal de Pernambuco, utilizándose el método de entrevista semiestructurada, en el período de abril a julio de 2007. Los testimonios obtenidos de las grabaciones transcriptas fueron sometidos al método de análisis de contenido, modalidad temática transversal. Se identificaron cuatro temáticas relacionadas con los objetivos del estudio: 1. La percepción del concepto de obesidad, 2. La obesidad afectando la autoimagen, 3. Obesidad versus salud, y 4. El difícil retorno a la salud. Los adolescentes reconocieron a la obesidad como una enfermedad que acarrea repercusiones negativas en su salud, generándoles una baja autoestima y sensaci

  3. Percepción de la propia imagen corporal en pacientes obesos o con sobrepeso.

    Directory of Open Access Journals (Sweden)

    Faustino Abad Massanet

    2012-08-01

    Full Text Available La obesidad es un importante problema de salud en la comunidad, y su abordaje es complejo. La valoración de la propia imagen corporal podría ser de ayuda, en pacientes obesos o con sobrepeso, para orientar hacia la obtención de un peso más saludable. Con este objetivo se utilizó una escala de figuras (escala de Stunkard en pacientes de estas características, comparando la figura seleccionada por cada participante con la correspondiente a su Índice de Masa Corporal real. La concordancia entre ambas fue escasa, con marcado predominio de sujetos que infravaloran su IMC. El error en la valoración fue significativamente mayor entre las mujeres, en los participantes con menor nivel de estudios, y entre los que presentaban algún componente del síndrome metabólico.

  4. Educação para a saúde a grupo de obesos

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    Glaci de Oliveira Pinto Vargas

    1983-03-01

    Full Text Available Este trabalho foi realizado por enfermeiras que atuam a nível ambulatorial, num Programa de Adulto, no Serviço de Saúde Pública, de um hospital geral de Porto Alegre, RS. É uma contribuição original de uma pesquisa descritivo analítica, com grupos de clientes obesos, atendidos através de cursos de educação para a saúde. Pretende-se avaliar quatro aspectos sem ordem de prioridade: a interesse da clientela pela educação da saúde, em grupo; b impressão, em relação aso conteúdos desenvolvidos; c redução do peso; d mudança de algum hábito de vida.

  5. Influencia do indice de massa corporal no equilibrio e na configuracao plantar em obesos adultos

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    Liu Chiao Yi

    2014-01-01

    Full Text Available INTRODUÇÃO: A obesidade é uma doença crônica degenerativa multifatorial que pode levar a alterações do sistema musculoesquelético, como mudança do centro de gravidade e sobrecarga mecânica sobre os membros inferiores. OBJETIVOS: Correlacionar o índice de massa corporal (IMC com o equilíbrio corporal e verificar associação entre o IMC e a configuração plantar. MÉTODOS: Foram avaliados 30 obesos, de ambos os gêneros, com IMC maior ou igual a 30 Kg/m². Inicialmente, os voluntários foram submetidos às avaliações de medidas antropométricas a fim de calcular o valor do IMC. Em seguida, foram submetidos ao teste de equilíbrio corporal estático Balance Error Scoring System (BESS e a plantigrafia para a identificação da impressão plantar. Por meio do método de Viladot, os voluntários foram classificados em grupos: pé plano (GPP, pé cavo (GPC e pé neutro (GPN. A correlação entre as variáveis IMC e BESS foi calculada por meio do coeficiente de correlação linear de Pearson e associação entre o IMC e a configuração plantar foi realizada por meio da análise de variância (Anova. Para todas as análises, nível de significância considerado foi p < 0,05. RESULTADOS: Os valores da correlação entre o IMC e o BESS foram r = - 0,1 e p = 0,59. Os valores da associação do IMC entre GPN - GPP; GPN - GPC; GPP - GPC foram respectivamente: p = 0,76; p = 0,001; p = 0,07. CONCLUSÃO: O índice de massa corporal de adultos obesos não influencia o equilíbrio corporal, porém influencia na configuração plantar.

  6. Efeitos de diferentes graus de sensibilidade a insulina na função endotelial de pacientes obesos Efectos de diferentes grados de sensibilidad a la insulina en la función endotelial de pacientes obesos Effects of different degrees of insulin sensitivity on endothelial function in obese patients

    Directory of Open Access Journals (Sweden)

    Roberto Galvão

    2012-01-01

    Full Text Available FUNDAMENTO: A obesidade derivada da deposição de gordura intra-abdominal tende a aumentar a produção de hormônios e citoquinas, piorando a sensibilidade a insulina e levando a disfunção endotelial. A hiperinsulinemia é considerada um fator de risco independente para doença isquêmica cardíaca e é uma causa de disfunção endotelial em indivíduos saudáveis. OBJETIVO: Avaliar o impacto de diferentes graus de resistência a insulina, medida pelo HOMA-IR (Homeostasis Model Assessment of Insulin Resistance, sobre a função endotelial de obesos, pacientes não diabéticos, sem história prévia de eventos cardiovasculares e diversos componentes da síndrome metabólica. MÉTODOS: Um total de 40 indivíduos obesos foi submetido a medidas antropométricas, pressão arterial de consultório, MAPA e exames laboratoriais, além de avaliação ultrassonográfica não invasiva da função endotelial. Os pacientes foram divididos em três grupos de acordo com o grau de resistência a insulina: pacientes com valores de HOMA-IR entre 0,590 e 1,082 foram incluídos no Grupo 1 (n = 13; entre 1,083 e 1,410 no Grupo 2 (n = 14; e entre 1,610 e 2,510 no Grupo 3 (n = 13. RESULTADOS: Encontramos uma diferença significativa na vasodilatação mediada por fluxo no Grupo 3 em relação ao Grupo 1 (9,2 ± 7,0 vs 18,0 ± 7,5 %, p = 0,006. Houve uma correlação negativa entre a função endotelial e insulina, HOMA-IR e triglicérides. CONCLUSÃO: Nosso estudo sugere que leves alterações nos níveis de resistência a insulina avaliada pelo HOMA-IR podem causar algum impacto sobre a função vasodilatadora do endotélio em indivíduos obesos não complicados com diferentes fatores de risco cardiovascular.FUNDAMENTO: La obesidad derivada del depósito de grasa intraabdominal tiende a aumentar la producción de hormonas y citocinas, empeorando la sensibilidad a la insulina y llevando a disfunción endotelial. La hiperinsulinemia es considerada un factor de

  7. Niimina Ahubiya: Western Mono Song Genres

    OpenAIRE

    Loether, Christopher

    1993-01-01

    Although Native American communities may lose their ancestral language or other aspects of their traditional culture, music seems to be more resistant to the continual onslaught of the dominant Euro-American culture. Even today, traditional music remains a vital part of Native American communities throughout the United States. In this article I examine one aspect of the musical traditions of the Western Mono, specifically the different types of songs, and their functions within Western Mono s...

  8. Alterações ortopédicas em crianças e adolescentes obesos

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    Michelle Brandalize

    Full Text Available INTRODUÇÃO: A obesidade infanto-juvenil é um problema muito frequente e implica complicações que podem estar presentes precocemente, como as alterações ortopédicas. OBJETIVO: descrever as alterações que atingem o aparelho locomotor em crianças e adolescentes com sobrepeso e obesidade. METODOLOGIA: Foram consultadas as bases de dados MEDLINE, SciELO, LILACS, ISI e base de dados da Universidade de Standford, com a combinação dos seguintes descritores: "obesidade", "complicações", "criança", "dores músculo-esqueléticas", "postura", "alterações ortopédicas", "marcha" e seus respectivos sinônimos em inglês. RESULTADOS: Pôde-se observar que as crianças e adolescentes obesos são mais predispostos a apresentar essas complicações ortopédicas que os indivíduos eutróficos, e os principais problemas relatados foram as alterações posturais, como hiperlordose lombar e joelhos valgos, e dores músculo-esqueléticas, principalmente na coluna lombar e membros inferiores. Os principais fatores que causam esses problemas não são bem definidos, mas incluem aumento da sobrecarga articular associado à fragilidade óssea em fase de crescimento e à diminuição da estabilidade postural, o que conduz ao aumento das necessidades mecânicas regionais. CONCLUSÃO: A identificação precoce dessas disfunções é fundamental para que essas crianças recebam tratamento multidisciplinar adequado.

  9. Microbial degradation of monocyclic and polycyclic aromatic hydrocarbons in case of limited pollutant availability with nitrate as a potential electron acceptor; Der mikrobielle Abbau mono- und polyzyklischer aromatischer Kohlenwasserstoffe bei einer begrenzten Schadstoffverfuegbarkeit mit Nitrat als potentiellem Elektronenakzeptor

    Energy Technology Data Exchange (ETDEWEB)

    Linke, C.

    2001-07-01

    The possibility of using natural degradation processes for long-term remediation of tar oil contaminated sites was investigated. Field studies have shown that microbial decomposition of pollutants does take place in many sites but that it is limited by limited availability of pollutants and oxygen in soil. The investigations focused on the activation of BTEX and PAH degradation in situ by nitrate in the absence or in the presence of oxygen. Tensides should be used in order to enhance the availability of pollutants in water, especially in the case of hardly water-soluble PAH. A large-scale experiment was carried out on tar oil contaminated terrain; it was found that the availability of oxygen and not of PAH is the limiting factor so that adding of surfactants will not improve pollutant degradation. In contrast, the adding of tensides would mean even higher concentrations of oxygen-depleting substances in soil. [German] In der vorliegenden Arbeit wurden im Hinblick auf langfristige Sanierungsstrategien fuer teeroelkontaminierte Standorte Moeglichkeiten der Nutzung natuerlicher Abbauvorgaenge untersucht. Zahlreiche Feldstudien belegen, dass ein mikrobieller Schadstoffabbau an vielen Standorten stattfindet, dieser jedoch sowohl durch eine begrenzte Schadstoffverfuegbarkeit als auch durch den im Untergrund nur begrenzt zur Verfuegung stehenden Sauerstoff limitiert wird. Ziel dieser Arbeit war es abzuklaeren, inwiefern ein BTEX- und PAK-Abbau in situ auch in Abwesenheit von Sauerstoff durch Nitrat allein oder durch Nitrat in Kombination mit Sauerstoff aktiviert werden kann. Um insbesondere fuer die schlecht wasserloeslichen PAK eine ausreichende Schadstoffverfuegbarkeit zu gewaehrleisten, sollten auch Tenside zur Erhoehung der im Wasser vorliegenden Schadstoffmenge eingesetzt werden. Aufbauend auf die Laboruntersuchungen wurde im Rahmen von VEGAS{sup ix} ein Grossversuch zum mikrobiellen PAK-Abbau im Abstrom einer simulierten Teeroelkontamination durchgefuehrt

  10. Motivação à prática regular de atividades físicas e esportivas: um estudo comparativo entre estudantes com sobrepeso, obesos e eutróficos Motivation of regular physical and sporting activities practice: a comparative study between obeses, overweight, and other students

    Directory of Open Access Journals (Sweden)

    Marcos Alencar Abaide Balbinotti

    2011-09-01

    Full Text Available O principal objetivo do presente estudo é comparar os níveis de motivação à prática regular de atividades físicas de três diferentes grupos de alunos das escolas de ensino fundamental e médio do município de Erechim/RS: Obesos, com sobrepeso, e eutróficos. Para tanto, além das avaliações antropométricas - massa corporal e altura - foi aplicado o Inventário de motivação à prática regular de atividades físicas e esportivas (IMPRAFE-54 ( BALBINOTTI; BARBOSA, 2006 . Os resultados variaram consideravelmente em valores nominais e a principais dimensões motivacionais foram as seguintes: Obesos (saúde; sobrepeso (estética; saúde; prazer; eutróficos (saúde, estética, prazer. Na comparação inter-grupo (obesos; sobrepeso; eutróficos, a dimensão Estética se destacou na diferença entre os grupos de sobrepesos e obesos. Espera-se que esses resultados possam contribuir para a prática pedagógica da educação física escolar.The main intent of the present study is compare the motivation levels of regular physical activities practice of three differents scholars groups from elementary and middle schools of Erechim/RS municipal district: Obeses, overweight, and Eutrophic. Then, besides the anthropometry evaluations - corporal mass and height - was applied the "Inventário de motivação à prática regular de atividades físicas e esportivas" (IMPRAFE-54 ( BALBINOTTI; BARBOSA, 2006 . The results varied considerably in nominal values and the main motivation dimensions were as follows: Obeses (health; overweight (esthetics; health; joy; Eutrophic (health; esthetics; joy. In comparing inter-group (obese, overweight, Eutrophic, the Aesthetic dimension stood out in the difference between the groups of overweight and obese. Hope these results might contribute for the pedagogy practice in scholar physical education.

  11. Biopolítica e confissão: cenas do grupo terapêutico com pacientes obesos

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    Shirley Dias Gonçalves

    2012-01-01

    Full Text Available Este trabalho é baseado numa pesquisa realizada em um hospital público, especializado em cirurgia bariátrica na cidade de Fortaleza- CE e teve como objetivo investigar os discursos que circulam no grupo terapêutico realizado com pacientes diagnosticados obesos e como esses pacientes são subjetivados por esses discursos. A metodologia utilizada foi a observação participante do referido grupo composto por pacientes de ambos os sexos que estavam na fase pré e pós-operatória. Foram analisados dois dispositivos presentes no controle da obesidade: a biopolítica e a confissão. A cirurgia bariátrica funciona como uma estratégia biopolítica que incide sobre o corpo de uma população obesa e a confissão atua como tecnologia de si. Assim, esse trabalho buscou problematizar como o corpo obeso é demarcado por práticas de saber-poder que o constituem. Também se tratou de analisar as resistências ao discurso médico-científico sobre saúde, beleza e boa forma dos corpos.

  12. Vias aéreas e conteúdo gástrico no paciente obeso Vías aéreas y contenido gástrico en el paciente obeso The airways and gastric contents in obese patients

    OpenAIRE

    Leonardo de Andrade Reis; Guilherme Frederico Ferreira dos Reis; Milton Roberto Marchi de Oliveira

    2010-01-01

    JUSTIFICATIVA E OBJETIVOS: O presente artigo teve como objetivo rever as referências bibliográficas e questionar o conceito de que o obeso deve ser considerado de estômago cheio, questionando, consequentemente, a forma como a via aérea deve ser abordada na indução da anestesia geral, considerada de difícil acesso devido à obesidade. CONTEÚDO: Classicamente, o paciente obeso é considerado de estômago cheio, levando a condutas protetoras das vias aéreas durante a indução da anestesia geral. Fre...

  13. O efeito em curto prazo do bypass gástrico sobre pacientes obesos diabéticos

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    Aluisio Stoll

    Full Text Available OBJETIVO: estudar o efeito do bypass gástrico sobre a glicemia e o uso de medicação antidiabética em pacientes obesos portadores de diabetes. MÉTODOS: estudo de coorte retrospectivo com 44 pacientes obesos portadores de DM2, provenientes de 469 pacientes submetidos ao bypass gástrico no período de dezembro de 2001 a março de 2009. Os desfechos primários avaliados foram: glicemia em jejum e a necessidade de medicação antidiabética. RESULTADOS: a população foi composta de dez (22,7% homens e 34 (77,3% mulheres, com média de idade de 45,3 (±8,23 anos e índice de massa corporal de 40,9 (±5,03 kg/m². O tempo médio de evolução do DM2 foi 63,6 (±60,9 meses. Dos 40 pacientes que utilizavam medicação para controle do DM2, 20 (50% tiveram sua medicação suspensa na alta hospitalar e 13 (32,5% até nove meses depois. Em uma paciente não foi possível avaliar o uso de medicação, sendo essa a única exclusão. A insulina foi suspensa nos dez (100% pacientes que a utilizavam, sendo seis (60% na alta hospitalar. Houve redução (P<0,05 da glicemia em jejum, em todo o período estudado, em comparação com o valor pré-operatório, e foram atingidos valores inferiores a 100mg/dl no período de sete a nove meses. CONCLUSÃO: Pacientes obesos portadores de DM2, submetidos ao bypass gástrico, apresentaram melhora do controle glicêmico e redução do uso de hipoglicemiantes em curto prazo.

  14. Aptidão cardiorrespiratória, perfil lipídico e metabólico em adolescentes obesos e não-obesos Cardiorespiratory fitness, lipid and metabolic profile in obese and non-obese adolescents

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    Neiva Leite

    2009-09-01

    Full Text Available O objetivo deste estudo foi investigar a relação entre o consumo máximo de oxigênio, perfil lipídico e metabólico em meninas e meninos obesos e não-obesos. Estudo transversal, descritivo e correlacional. A amostra foi composta por 91 obesos e 30 não-obesos, dos 10 aos 16 anos. Avaliou-se o índice de massa corporal (IMC e a circunferência abdominal (CA. A aptidão cardiorrespiratória foi avaliada de forma direta através da análise do consumo máximo de oxigênio (O2max. Determinaram-se níveis de colesterol total (CT, lipoproteína de alta densidade (HDL-C, lipoproteína de baixa densidade (LDL-C, triglicérides (TG, glicemia e insulinemia após 12 horas de jejum. Analisaram-se os dados pelo teste "t" de student e correlação parcial controlada pela idade, com um nível de significância de pO2max com o IMC (r = -0,540; p O2max com a CT, a fração LDL-C e a glicemia.O menor VO2max correlacionou com maiores adiposidade, TG e insulinemia, bem como redução de HDL. O O2max não correlacionou com o CT, LDL-C e glicemia, sugerindo a importância do controle genético sobre estas variáveis e um menor tempo de influência do sedentarismo na população infanto-juvenil.The aim this study was investigates the relationship between maximum oxygen consumption, lipid and metabolic profile in obese and non-obese girls and boys. Transversal, descriptive and correlational study. 91 obese and 30 non-obese subjects participated, with 10 to 16 years. There were well overall adiposity by body mass index (BMI, and central adiposity by waist circumference (WC. The cardiorespiratory fitness was assessed by a direct analysis of maximum oxygen consumption (O2max. Are determined levels of total cholesterol (TC, high density lipoprotein (HDL-C, low density lipoprotein (LDL-C, triglycerides (TG, glucose and insulin after 12 hours of fasting. We analyzed the data by "t" student`s test and partial correlation controlled for age, with a significance level of p

  15. Resultados de una intervención motivacional con niños obesos o con sobrepeso y sus familias: Estudio Piloto

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    Pedro Juan Tárraga López

    2017-12-01

    Full Text Available Introducción: el objetivo fue analizar los resultados de una intervención motivacional con modificación de los hábitos alimentarios, los estilos de vida y los trastornos emocionales en niños obesos de 6 a 12 años y sus familias. Material y métodos: Estudio de intervención con evaluación pre- y posintervención del programa Familias en Movimiento. Se incluyeron 11 niños (10 niñas y 1 niño de 6 a 12 años tratados con otros programas para la pérdida de peso sin éxito. Se evaluaron al inicio y al final los parámetros: Índice de Masa Corporal (IMC, los resultados de los cuestionarios: de Dieta Mediterránea y ansiedad en niños y el peso y la ansiedad de los adultos tras la intervención. Resultados: El IMC disminuyó de una mediana de 25,2 (Rango intercuartílico de 23,3–28,0 a 23,9 y (22,9–27,6 tras la intervención, cambio no estadísticamente significativo (p<0,086. La mediana de adherencia a la Dieta Mediterránea aumentó significativamente en 2,2 puntos (7,1 a 9,3, debido principalmente a que un mayor número de niños tomaban desayuno (44% y hubo una disminución del consumo de golosinas y bollería industrial en el desayuno (22,2%. La intervención redujo significativamente en 8,7 puntos la ansiedad en los niños. De los adultos, 9 de ellos participaron en la evaluación inicial, la media de disminución de peso fue de 3,6kg y la disminución de la ansiedad pasó de 45,6 a 27,3 (p=0,02. Conclusiones: La aplicación del programa Familias en Movimiento disminuyó el IMC, aumentó la puntuación en la adherencia a Dieta Mediterránea y disminuyó la ansiedad en los niños, además se redujo el peso y la ansiedad en los adultos que acompañaron en el programa a los niños.

  16. Tubes, Mono Jets, Squeeze Out and CME

    Energy Technology Data Exchange (ETDEWEB)

    Longacre, R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-10-23

    Glasma Flux Tubes, Mono Jets with squeeze out flow around them plus the Chiral Magnetic Effect(CME) are physical phenomenon that generate two particle correlation with respect to the reaction plane in mid-central 20% to 30% Au-Au collision √sNN = 200.0 GeV measured at RHIC.

  17. Avaliação do desempenho físico e funcional respiratório em obesos

    Directory of Open Access Journals (Sweden)

    Kadma Karênina Damasceno Soares

    Full Text Available INTRODUÇÃO: O desempenho físico tem se tornado importante objeto de estudo em obesos para a avaliação pré-operatória de cirurgia bariátrica. Contudo, ainda há escassez de estudos, especialmente, no que se refere aos testes de campo ou de capacidade funcional. OBJETIVO: comparar os resultados do Teste de Caminhada de seis Minutos (TC6' com os do Shuttle Walk Test (SWT em mulheres obesas, juntamente com as respostas do questionário HAQ-20. METODOLOGIA: avaliaram-se 13 mulheres, com idade média de 44 ± 11 anos e com Índice de Massa Corpórea (IMC 43 ± 5 kg/m², submetidas, aleatoriamente e de forma consecutiva, a TC6', SWT, espirometria, força muscular respiratória e questionário HAQ-20. RESULTADOS: Constatou-se que as distâncias apresentaram-se significativamente diferentes (TC6' = 489 ± 129 m e SWT = 244 ± 161 m, sendo que o score do HAQ-20 apresentou uma mediana de 1,125. Quando verificada a correlação do HAQ-20 com TC6' e o SWT, esta foi constatada apenas para o domínio vestir-se com os resultados do TC6. CONCLUSÃO: Com base nesses resultados, conclui-se que a distância percorrida no TC6' foi maior que no SWT, o que sugere melhor aplicabilidade do TC6' em obesos, sendo, nesse caso, possivelmente mais sensível na avaliação da capacidade funcional que o SWT. Os resultados do HAQ-20 foram pouco discriminadores, pois um domínio entre oito mostrou-se significativo quando correlacionado com as distâncias percorridas.

  18. Avaliação da composição corporal em adolescentes obesos: o uso de dois diferentes métodos Evaluación de la composición corporal en adolescentes obesos: uso de dos metodos diferentes Body composition evaluation in obese adolescents: the use of two different methods

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    Marco Túlio de Mello

    2005-10-01

    Full Text Available A pletismografia é um método rápido e fácil para determinação da composição corporal que utiliza a relação inversa entre pressão e volume. O objetivo do presente estudo foi o de comparar os valores obtidos com o método pletismografia com os valores observados com o DEXA em uma população de adolescentes obesos. Participaram da amostra 88 adolescentes pós-púberes de ambos os sexos, com idades entre 15 e 19 anos (17,01 ± 1,6 ingressantes de um programa de atividade física multidisciplinar. Os voluntários foram submetidos a uma avaliação da composição corporal em dias distintos dentro da mesma semana, pelo método de pletismografia e outra avaliação pelo método DEXA. Quando os métodos foram comparados, não se observaram diferenças significativas entre eles; além disso, foram observadas correlações significativas entre os parâmetros comuns dos dois métodos (massa magra, massa gorda (kg e massa gorda (%, r = 0,88 p La pletismografía es un método rápido y fácil para la determinación de la composición corporal que utiliza la relación inversa entre la presión y el volumen. El objetivo del presente estudio fué el de comparar los valores obtenidos con el metodo pletismografia con los valores observados con el DEXA en una población de adolescentes obesos. Participaron de la muestra 80 adolescentes post púberes de ambos sexos, con edades entre los 15 y los 19 años (17,01±1,6 iniciantes en un programa de actividad física multidisciplinar. Los voluntarios fueron sometidos a una evaluación de la composición corporal en días distintos dentro de la misma semana, por el método de pletismografia y otra evaluación por el método DEXA. Cuando se compararon los métodos, no fueron observadas diferencias significativas entre ellos, además de ello, fueron observadas correlaciones entre los parámetros comunes a los dos métodos (masa magra, masa grasa (kg y masa gorda (%, r = 0,88 p Plethysmography is an easy and

  19. Características miofuncionais de obesos respiradores orais e nasais Myofunctional characteristics of obese mouth and nose breathers

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    Denise Bolzan Berlese

    2012-06-01

    Full Text Available OBJETIVO: Investigar as características miofuncionais de obesos respiradores orais e nasais. MÉTODOS: Foram selecionados por conveniência 24 obesos, com idades entre 8 e 15 anos, pertencentes ao Grupo de Obesidade do Ambulatório de Pediatria de um Hospital Universitário. As características miofuncionais foram avaliadas por meio do protocolo de Avaliação Miofuncional Orofacial com Escalas (AMIOFE. RESULTADOS: Foi observada respiração oral em 62,5%, e respiração nasal em 37,5% da população estudada. No grupo de respiradores orais, 40% apresentaram oclusão com tensão dos lábios e 80% palato com largura diminuída, enquanto que quase todos os respiradores nasais tinham palato e lábios com postura normal. Interposição da língua nos arcos dentários ocorreu em 47% dos respiradores orais e em nenhum dos respiradores nasais. Os respiradores orais mostraram tendência em não repetir a deglutição de um mesmo bolo alimentar. A aparência da face, condição postural da mandíbula, bochechas e função de mastigação foram semelhantes nos dois grupos. CONCLUSÃO: A respiração oral em crianças e adolescentes obesos foi acompanhada de alterações miofuncionais do sistema estomatognático, representadas por diminuição da largura do palato, interposição da língua aos arcos dentários, oclusão dos lábios com tensão e alteração da deglutição.PURPOSE: To investigate the myofunctional characteristics of nasal and oral breathing in obese individuals. METHODS: Participants were 24 obese individuals with ages between 8 and 15 years, who participated in the Obesity Group of the Ambulatory of Pediatrics of an University Hospital, and were selected by convenience. The myofunctional characteristics were assessed using the Orofacial Myofunctional Assessment with Scales (Avaliação Miofuncional Orofacial com Escalas - AMIOFE protocol. RESULTS: Oral breathing was present in 62.5%, and nasal breathing in 37.5% of the population

  20. Estudo do sono e função pulmonar em pacientes obesos mórbidos

    Directory of Open Access Journals (Sweden)

    Isabella de Carvalho Aguiar

    Full Text Available INTRODUÇÃO: A obesidade acarreta uma série de alterações na fisiologia respiratória e no sono. Seu tratamento tem como objetivo a melhora da saúde e da qualidade de vida. OBJETIVO: Avaliar a função pulmonar e o sono em indivíduos obesos mórbidos pré-cirurgia bariátrica. MATERIAIS E MÉTODOS: Participaram deste estudo 38 pacientes, recrutados em dois serviços de cirurgia bariátrica e encaminhados ao Laboratório de Sono da Universidade Nove de Julho, São Paulo, Brasil. Os critérios de inclusão foram: obesos mórbidos, IMC entre 40 kg/m² e 50 kg/m² e IMC entre 35 kg/m² a 39,9 kg/m² se associados a comorbidades. RESULTADOS: A média de idade foi de 42 ± 10, o índice de massa corpórea médio foi de 50,09 ± 7,64. A média da circunferência abdominal foi de 132,48 ±11,07 e 134,31 ± 16,26 e de pescoço foi 42,34 ± 2,08 e 44,48 ± 3,67, respectivamente para mulheres e homens. As pressões máximas inspiratórias foram 57,57 ± 18,93 e 60,6 ± 3,72 e máximas expiratórias 56,63 ± 16,68 e 60 ± 18,52, para mulheres e homens respectivamente. O sono do movimento rápido dos olhos apresentou-se com média de 16,93 ± 13,61 e a saturação mínima da oxi-hemoglobina foi de 79,33 ± 10,26 durante o sono. Em 44,74% dos casos examinados, foram observadas alterações na Escala de Sonolência de Epworth (ESE; e em 76,3% ficou confirmada a presença de síndrome da apneia obstrutiva do sono (SAOS. CONCLUSÃO: Foram observadas alterações nas pressões máximas ventilatórias, na estrutura do sono associadas a considerável dessaturação noturna da oxi-hemoglobina, o que evidencia alta prevalência de SAOS nos pacientes obesos mórbidos.

  1. Método do limiar de variabilidade da frequência cardíaca aplicado em pré-adolescentes obesos e não obesos Método del umbral de variabilidad de la frecuencia cardíaca aplicado en preadolescentes obesos y no obesos Method of heart rate variability threshold applied in obese and non-obese pre-adolescents

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    Mário Augusto Paschoal

    2011-06-01

    Full Text Available FUNDAMENTO: A detecção do limiar anaeróbico (LA pela análise da variabilidade da frequência cardíaca (LiVFC pode significar uma nova maneira de avaliação da capacidade funcional cardiorrespiratória (CFCR em pré-adolescentes. OBJETIVO: Testar o método de LiVFC para detecção do LA em pré-adolescentes não obesos (NO, obesos (O e obesos mórbidas (OM, a fim de determinar diferenças em sua CFCR. MÉTODOS: Foram estudados 30 pré-adolescentes, com idades entre 9 e 11 anos, divididos em três grupos de 10: a grupo NO - índice de massa corpórea (IMC com percentil do National Center for Chronic Disease Prevention and Health Promotion entre 5 e 85; b grupo O - IMC de percentil entre 95 e 97 e c grupo OM - IMC com percentil acima de 97. Todos foram submetidos a um protocolo incremental realizado em esteira rolante e registraram-se os batimentos cardíacos para detecção do LiVFC, que foi determinado pelo valor de 3,0 ms do índice do desvio-padrão 1 (SD1, extraído dos intervalos RR. RESULTADOS: Os valores médios no momento do LiVFC mostraram maiores valores para o grupo NO, destacando-se: a VO2 (ml/kg/min NO = 27,4 ± 9,2; O = 13,1 ± 7,6 e OM = 11,0 ± 1,7; b FC (bpm: NO = 156,3 ± 18,0; O =141,7 ± 11,4 e OM = 137,7 ± 10,4; e c distância percorrida (metros: NO = 1.194,9 ± 427,7; O = 503,2 ± 437,5 e OM = 399,9 ± 185,1. CONCLUSÃO: O LiVFC se mostrou efetivo para avaliação da CFCR e poderá vir a ser aplicado como método alternativo à ergoespirometria em determinadas situações.BACKGROUND: La detección del umbral anaeróbico (UA por el análisis de la variabilidad de la frecuencia cardíaca (LiVFC puede significar una nueva manera de evaluación de la capacidad funcional cardiorrespiratoria (CFCR en preadolescentes. OBJECTIVE: Testear el método de LiVFC para detección del UA en preadolescentes no obesos (NO, obesos (O y obesos mórbidos (OM, a fin de determinar diferencias en su CFCR. METHODS: Fueron estudiados 30

  2. “... Essa coisa começou a pegar!” – vivências cotidianas de homens obesos

    Directory of Open Access Journals (Sweden)

    Carminda Maria Goersch Fontenele Lamboglia

    2016-03-01

    Full Text Available Objetivo: Conhecer as vivências cotidianas de homens com obesidade mórbida. Métodos: Pesquisa com abordagem qualitativa. Foram entrevistados nove homens com diagnóstico de obesidade mórbida que estavam em seguimento no pré-operatório para cirurgia bariátrica, com idade de 27 a 50 anos, casados, com renda familiar de dois a três salários mínimos, caso de obesidade na família e hipertensão como comorbidade. A investigação ocorreu no período de maio a setembro de 2012 em um hospital de referência no tratamento à obesidade e realização de cirurgia bariátrica em Fortaleza, Ceará, Brasil. Realizaram-se entrevistas semiestruturadas com análise, através da Análise de Conteúdo, do tipo análise temática. Eis as categorias de análise definidas: tornar-se obeso, vivências cotidianas do homem obeso e cirurgia bariátrica – um caminho possível para um cotidiano com saúde. Resultados: Os principais achados relacionaram-se a uma rotina diária fixa, com reduzido espaço para atividade física e de lazer. A obesidade, para 90% dos entrevistados, existe desde a infância e trouxe dificuldade na realização das ocupações no dia a dia. Esses homens optaram pela cirurgia por não perderem peso com dieta, exercício e medicamento, em razão da permanência de problemas de saúde, bem como dificuldades nas relações afetivas e no trabalho. Conclusão: Identificou-se a demanda de uma reorganização das vivências cotidianas dos homens para que haja uma efetiva ação da cirurgia bariátrica, a fim de que os usuários sejam protagonistas dessa modificação, inserindo atividades saudáveis e contínuas no seu cotidiano.

  3. Expresión génica en pacientes obesos con enfermedad hepática por depósito de grasa Gene expression in obese patients with non-alcoholic steatohepatitis

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    A. Cayón

    2008-04-01

    Full Text Available La fisiopatología de la enfermedad hepática por depósito de grasa sólo se conoce de forma parcial. En este trabajo hemos analizado la expresión génica intrahepática de citoquinas, quimioquinas, receptores celulares, factores de crecimiento, transductores de señales intracelulares y proteínas de comunicación extracelular en el tejido hepático de sujetos obesos con y sin esteatohepatitis no alcohólica, en un intento de determinar un perfil de expresión génica asociado a las formas severas de la esteatohepatitis no alcohólica (EHNA. Se analizó un grupo de 38 pacientes obesos con un IMC > 35, que fueron sometidos a cirugía bariátrica. La expresión génica intrahepática se determinó en el tejido hepático dividiendo a los pacientes en tres grupos: a pacientes obesos sin datos histológicos sugestivos de EHNA (n = 12; b pacientes con EHNA sin fibrosis (n = 13; y c pacientes con EHNA y fibrosis (n = 13. Se consideró que existía una sobreexpresión génica cuando la diferencia en la expresión era, al menos, de dos veces con respecto al grupo control. Los resultados se confirmaron mediante PCR en tiempo real. Se detectó una expresión diferencial de 14 genes (10 sobreexpresados y 4 infraexpresados. Los genes sobreexpresados incluyeron prohibitina, TNF, TNF RI (p55, MCSF, R2-TRAIL, TGF-b1, CTGF, FGF, VEGF, BIGH3 y ObRb. La expresión de los genes insulin growth factor-1, insulin growth factor-2, interleuquina-2 y tyrosine-receptor fue menor que en el grupo control. En conclusión: 1. Los pacientes obesos con EHNA sin fibrosis muestran una sobreexpresión de genes proinflamatorios y proapoptóticos. En los pacientes con EHNA y fibrosis, se observa, además, una sobreexpresión de genes profibrogénicos, incluyendo el gen del receptor de la leptina. 2. La expresión de prohibitiva en los pacientes con EHNA, tanto con fibrosis como sin fibrosis, fue superior que en los controles, lo que sugiere una disfunción mitocondrial en los

  4. Qualidade de sono de trabalhadores obesos de um hospital universitário: acupuntura como terapia complementar

    Directory of Open Access Journals (Sweden)

    Mariana Lourenço Haddad

    2012-02-01

    Full Text Available O objetivo do estudo foi verificar o efeito da acupuntura na qualidade de sono de trabalhadores obesos em um hospital universitário. Os dados foram coletados no período de julho a outubro de 2009, junto a 37 funcionários, submetidos a oito aplicações semanais de acupuntura. O Índice de Qualidade de Sono de Pittsburgh foi utilizado para identificar a qualidade de sono dos sujeitos antes e após a intervenção. Os resultados mostram que antes da intervenção cinco (13,5% pessoas apresentaram boa qualidade de sono e, ao final da intervenção, 14 (37,8% relataram este quadro. A diferença obtida na comparação das médias dos escores obtidos antes e após a acupuntura foi significativa (p=0,0001. Concluiu-se que a acupuntura produziu um efeito positivo sobre a qualidade do sono na amostra estudada, apresentando-se como uma técnica adjuvante no tratamento dos distúrbios do sono e consequentemente na melhoria da qualidade de vida desta população.

  5. Tornar-se obeso na adolescência pode trazer consequências à saúde mental?

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    Maria Cecília Formoso Assunção

    2013-09-01

    Full Text Available O estudo avaliou a associação entre trajetória de obesidade e dificuldades emocionais e comportamentais em adolescentes. Foram estudados 4.325 jovens, aos 11 e 15 anos de idade, pertencentes à coorte de nascimentos de 1993 de Pelo-tas, Rio Grande do Sul, Brasil. Informações sobre índice de massa corporal (IMC, avaliação materna da saúde emocional e comportamental do adolescente (Strengths and Difficulties Questionnaire - SDQ e características sociodemográficas e comportamentais foram utilizadas. As análises, estratificadas por sexo, foram conduzidas por meio de regressão linear simples e múltipla. A trajetória de obesidade mostrou associação com o escore total do SDQ, nas análises ajustadas, apenas entre os meninos. Entre esses, tornar-se obeso no período esteve relacionado com maior escore na subescala de problemas de relacionamento com os colegas. Diante do conhecimento atual sobre as implicações futuras da obesidade na saúde mental e em se tratando de adolescentes, sugere-se que estudos que avaliem as diferenças de gênero na adolescência possam contribuir para o entendimento da associação encontrada.

  6. On mono-W signatures in spin-1 simplified models

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    Ulrich Haisch

    2016-09-01

    Full Text Available The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artifact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  7. On mono-W signatures in spin-1 simplified models

    International Nuclear Information System (INIS)

    Haisch, Ulrich; Tait, Tim M.P.

    2016-03-01

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artefact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  8. Niños y adolescentes obesos con síndrome metabólico Obese children and adolescents with metabolic syndrome

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    José Raúl Zaldívar Ochoa

    2012-07-01

    Full Text Available Se realizó un estudio descriptivo y transversal de 200 niños y adolescentes obesos, con edades de 5 a 18 años, que acudieron a la consulta de Endocrinología del Hospital Docente Infantil Norte "Dr. Juan de la Cruz Martínez Maceira" de Santiago de Cuba, desde enero del 2008 hasta igual mes del 2010, a fin de determinar la existencia del síndrome metabólico en estos, para lo cual se consideraron las variables: edad, sexo, presencia de síndrome metabólico (según el National Cholesterol Education Program Adult Treatment Panel III, índice de masa corporal, bajo peso al nacer, antecedentes obstétricos de la madre (crecimiento intrauterino retardado, diabetes e hipertensión gestacionales y patológicos familiares (obesidad, diabetes mellitus e hipertensión arterial, así como parámetros bioquímicos. En la casuística se observó un bajo porcentaje del síndrome metabólico (12,0 %, con predominio en las edades de 15 a 18 años, el cual estuvo estrechamente relacionado con la circunferencia abdominal, que se presentó por encima de 95 percentil en 100,0 % de los pacientes; el bajo peso al nacer, que primó en 70,8 % de los afectados con la entidad clínica; y la severidad de la obesidad, que mostró la importante cifra de 95,8 % en la génesis de dicho síndrome.A descriptive and cross-sectional study was conducted in 200 obese children and adolescents between 5 and 18 years of age that attended the Endocrinology Department of «Dr. Juan de la Cruz Martínez Maceira» Northern Teaching Children Hospital in Santiago de Cuba, from January 2008 to January 2010, in order to determine the occurrence of metabolic syndrome in these patients, for which the variates such as age, sex, presence of metabolic syndrome (according to the National Cholesterol Education Program Adult Treatment Panel III, and body mass index, low birth weight, mother's reproductive history (intrauterine growth retardation, gestational diabetes and hypertension, family

  9. Finite Element Analysis Of Structural And Magmatic Interactions At Mono Basin (California)

    Science.gov (United States)

    La Marra, D.; Manconi, A.; Battaglia, M.

    2010-12-01

    Mono Basin is a northward trending graben situated east of the Sierra Nevada and west of Cowtrack Mountains, extending from the northern edge of Long Valley Caldera towards the Bodie Hills. From a hydrographic perspective, the Mono Basin is defined by all streams that drain into Mono Lake. The Mono-Inyo Craters forms a prominent 25-km-long volcanic complex from the NW corner of Long Valley caldera to the southern edge of Mono Lake. The late Quaternary Hartley Springs fault occurs along the Sierran range front between June Lake and the northern border of Long Valley Caldera. Recently it has been proposed that the manifestation of the volcanic and of the tectonic activity in this area is likely interrelated. According to Bursik et al (2003), stratigraphic data suggest that during the North Mono-Inyo eruption sequence of ~1350 A.D., a series of strong earthquakes occurred across the end of the North Mono explosive phase and the beginning of the Inyo explosive phase. Moreover, geological and geomorphic features of the Hartley Springs fault are consistent with rupture of the fault during the eruption sequence. We use the Finite Element Method (FEM) to simulate a three-dimensional model and investigate the feedback mechanism between dike intrusion and slip along the Hartley Springs fault. We first validate our numerical model against the Okada (1985) analytical solution for a homogeneous and elastic flat half-space. Subsequently, we evaluate the distribution of local stress changes to study the influence of the Inyo Dike intrusion in ~1350 A.D. on Hartley Springs fault, and how the fault slip may encourage the propagation of dikes towards the surface. To this end, we considered the standard Coulomb stress change as failure criterion. Finally, we analyze the effects of the topography and of vertical and lateral heterogeneities of the crust on the distribution of local and regional stress changes. In this presentation, we highlight the preliminary results of our analysis

  10. Prevalência de insuficiência venosa superficial dos membros inferiores em pacientes obesos e não obesos Prevalence of lower limbs superficial venous insufficiency in obese and non-obese patients

    Directory of Open Access Journals (Sweden)

    Amélia Cristina Seidel

    2011-06-01

    Full Text Available CONTEXTO: A insuficiência venosa crônica dos membros inferiores é a mais prevalente das doenças venosas. Muito se discute sobre sua etiologia e fisiopatologia. Vários fatores de risco têm sido associados ao seu desenvolvimento, como idade, sexo, dieta, entre outros. A obesidade é um problema de saúde pública e sua incidência tem aumentado. O ecocolor Doppler é um método útil para avaliar a presença de refluxo e/ou obstrução no sistema venoso. OBJETIVO: Comparar a prevalência de insuficiência venosa superficial e sintomas associados em pacientes obesos e não obesos. MÉTODOS: Após pesagem, medição da estatura e exame físico, os pacientes com índice de massa corpórea (IMC 35 kg/m² e queixas compatíveis com insuficiência venosa foram distribuídos nos grupos I e II, respectivamente. Foram submetidos à realização do ecocolor Doppler dos membros inferiores para avaliação da presença ou não de refluxo. RESULTADOS: Foram examinados 311 membros de 168 pacientes com 25-72 anos. Para análise estatística, foram consideradas queixas de varizes, dor, edema, dermatite, eczema e úlcera, associados ou não. Foi obtido um total de 109 e 104 membros com varizes nos grupos I e II, respectivamente. Queixas de varizes visíveis (pBACKGROUND: Chronic venous insufficiency of the lower limbs is the most prevalent venous disease. There is an ongoing debate about its etiology and pathophysiology. Several risk factors have been associated with its development, such as age, sex and diet. Obesity is a public health problem and its prevalence has been increasing. Color Doppler ultrasonography is a useful method to evaluate the presence of reflux and/or obstruction of the venous system. OBJECTIVE: To compare the prevalence of superficial venous insufficiency and associated symptoms in obese and non-obese patients. METHODS: After weighing, height measurement and physical examination, patients with body mass index (BMI 35 kg/m² and

  11. Calorimetria indireta x Harris Benedict: determinação, validação e comparação para cálculo da taxa metabólica de repouso em obesos grau III.

    OpenAIRE

    Carla Barbosa Nonino

    2002-01-01

    Vários estudos analisando a taxa de metabolismo de repouso (TMR) contribuíram com equações cuja proposta era estabelecer padrões que pudessem ser genericamente utilizadas para se estimar a TMR. A equação de Harris-Benedict (HB), permanece como o método mais comumente utilizado para estimar a TMR. Porém, em indivíduos obesos o uso de equações preditivas da TMR pode levar a resultados conflitantes. Indivíduos obesos submetidos a dietas hipocalóricas podem apresentar uma diminuição da TMR e do ...

  12. Evaluación de un programa integral de cuatro meses de duración sobre las condiciones preoperatorias de pacientes obesos candidatos a cirugía bariátrica

    OpenAIRE

    Delgado Floody, Pedro; Cofré Lizama, Alfonso; Alarcón Hormazábal, Manuel; Osorio Poblete, Aldo; Caamaño Navarrete, Felipe; Jerez Mayorga, Daniel

    2015-01-01

    Introducción: en los obesos morbidos existen antecedentes preoperatorios que deben ser mejorados para disminuir el riesgo de morbimortalidad. Objetivo: evaluar los efectos de un tratamiento multidisciplinar sobre parámetros antropométricos, glucosa basal, condición física y niveles de depresión y ansiedad en pacientes obesos candidatos a cirugía bariatrica. Material y métodos: cuatro hombres y diez mujeres entre 21 y 55 anos candidatos a cirugía bariatrica, con obesidad morbida (n = 5) u obes...

  13. Adiposidade corporal e hipertensão arterial em crianças e adolescentes obesos - doi:10.5020/18061230.2009.p88

    Directory of Open Access Journals (Sweden)

    Joel Saraiva Ferreira

    2012-01-01

    Full Text Available Objetivo: Investigar a relação entre a hipertensão arterial e adiposidade corporal em crianças e adolescentes obesos. Métodos: Estudo transversal no qual 129 crianças e adolescentes obesos de ambos os gêneros com idade variando de 7 a 14 anos foram avaliados. A adiposidade foi caracterizada a partir dos dados obtidos como: índice de massa corporal (IMC, percentual de gordura corporal (%GC e relação cintura-quadril (RCQ. O grupo foi dividido em dois subgrupos (normotensos e hipertensos mediante o nível de pressão arterial (PA. O teste estatístico de Kruskal Wallis foi empregado para determinar a significância na relação entre dados antropométricos e níveis de pressão arterial. Adotou-se um valor de p ? 0,05. Resultados: Verificou-se que 101 (78,29% participantes eram normotensos e 28 (21,71% hipertensos. Em relação à adiposidade, o grupo dos hipertensos apresentou níveis mais elevados de IMC e o %GC quando comparado com o normotenso (p<0,05. A partir dos dados da RCQ, não houve associação estatística entre a relação cintura-quadril e o nível pressórico. Conclusões: As crianças e adolescentes obesos apresentaram relação estatisticamente significativa entre adiposidade corporal e níveis de pressão arterial; no entanto, a localização da gordura não foi um fator determinante desta diferença.

  14. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

    Directory of Open Access Journals (Sweden)

    Thiago Bruder Nascimento

    2011-07-01

    Full Text Available FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C e obeso (OB, ratos sob dieta rica em gordura por 30 semanas. Após 30 semanas, foram registrados o peso corporal, índice de adiposidade, pressão arterial e perfis metabólicos e endócrinos dos animais. Foram obtidas curvas para noradrelanina na ausência e presença de inibidor de óxido nítrico sintase (L-NAME, 3x10-4M em aorta torácica intacta e com desnudamento em ratos C e OB. RESULTADOS: As medidas de peso corporal, índice de adiposidade, leptina e insulina aumentaram nos ratos OB, enquanto a pressão arterial permaneceu inalterada. A obesidade também produziu tolerância à glicose e resistência à insulina. A reatividade à noradrenalina da aorta intacta foi similar em ratos C e OB. A presença de L-NAME produziu um aumento similar nas respostas máximas, mas um desvio maior à esquerda das respostas nas aortas intactas dos ratos C em relação aos ratos OB [EC50 (x10-7M: C = 1,84 (0,83-4,07, O = 2,49 (1,41-4,38; presença de L-NAME C = 0,02 (0,01-0,04*, O = 0,21 (0,11-0,40*†,*p < 0,05 vs controle respectivo,†p < 0,05 vs controle mais L-NAME, n = 6-7]. Nenhum dos protocolos alterou a reatividade à noradrenalina de aortas com desnudamento. CONCLUSÃO: A obesidade induzida por dieta rica em gordura promove alterações metabólicas e vasculares. A alteração vascular envolveu uma melhora da via endotelial L-arginina/NO provavelmente relacionada à hiperinsulinemia e hiperleptinemia induzidas por dieta. A maior resistência aos efeitos do L-NAME na aorta de ratos obesos diz respeito a menor vulnerabilidade de indivíduos obesos na presença de patologias

  15. High pressure behaviour of uranium mono pnictides

    International Nuclear Information System (INIS)

    Pagare, Gitanjali; Ojha, Poonam; Sanyal, S.P.; Aynyas, Mahendra

    2006-01-01

    The pressure induced structural phase transition of three actinide mono pnictides AX (A=U and X=As, Sb, Bi), have been studied theoretically using two body interionic potential with necessary modifications to include the effect of Coulomb screening by the delocalized 5f electrons of the actinide (uranium) ion. The peculiar properties of these compounds have been interpreted in terms of the hybridization of f electrons with the conduction band. The calculated compression curves are compared with the experimental results. These compounds exhibits first order crystallographic phase transition from their NaCl (B 1 ) phase to CsCl (B 2 ) phase at 17GPa, 9.5GPa and 5.3 GPa respectively. The NaCl phase possesses lower energy than CsCl phase and stable at ambient pressure. (author)

  16. Scour properties of mono bucket foundation

    DEFF Research Database (Denmark)

    Stroescu, Ionut Emanuel; Frigaard, Peter Bak

    2016-01-01

    Field experience proved that the Mono Bucket Foundations (MBFs) have good response against scour development. Moreover, the ratio between large diameter (bucket lid) and the small diameter (shaft tower) is the driving parameter for the process of erosion/backfill, like scour protection diameter...... in the case of scour protected monopiles. However, the structural design to reduce the scour development for MBFs is still open to optimization. The influences of parameters that generate backfill and scour, the transfer load webs and the misalignment with seabed, have not been systematically studied until...... analysis compared with real surveys and existing studies showed good agreements. Scour protection based on collar solution shows high efficiency when scour protection should be required. The paper demonstrates good agreement between field measurements and small-scale studies. The unique value of the field...

  17. Uso do ultra-som para punção venosa central em paciente obeso com adenomegalia cervical

    Directory of Open Access Journals (Sweden)

    Jaderson Wollmeister

    2008-08-01

    Full Text Available JUSTIFICATICA E OBJETIVOS: As técnicas clássicas para punção venosa central são realizadas com base em referências anatômicas de superfície e conhecimento da anatomia vascular da região em que se realizará a punção. O uso do ultra-som permite a realização da punção sob visão direta das estruturas vasculares, peri-vasculares e da agulha de punção. O objetivo deste relato foi descrever o uso do ultra-som no auxílio de acesso venoso central em paciente obeso e com adenomegalias. RELATO DO CASO: Paciente do sexo masculino, branco, 28 anos, 1,70 m, 120 kg, com diagnóstico de linfoma de Hodgkin esclerose nodular. Solicitado ao Serviço de Anestesiologia do Hospital Governador Celso Ramos, punção de veia jugular interna direita guiada por ultra-som devido à presença de gânglio supraclavicular que prejudicava a referência anatômica de punção e à obesidade do paciente. Após a obtenção da melhor imagem a veia jugular interna esquerda foi puncionada e colocado um cateter venoso de triplo lúmen. A punção foi única, com progressão fácil do cateter e realizada sem complicações. CONCLUSÕES: O uso da ultra-sonografia para punção venosa central pode evitar complicações tornando o procedimento mais seguro para o paciente.

  18. La poesía ebanita y su precursor Candelario Obeso

    Directory of Open Access Journals (Sweden)

    Ramiro Lagos

    1983-01-01

    Full Text Available Colombia, crisol de un claro mestizaje acriollado, donde la raza se funda, no en el color sino en el bronce de su valor y de su épica, unido a esa patina de cultura que da al colombiano un perfil singular, es quizá una de las naciones que más se han liberado, por su cultura, de las consabidas discriminaciones que separan al blanco del negro, del mulato y del aindiado. No es Colombia un país estrictamente criollo como las naciones rioplatenses que se precian de su ancestro europeo. Sin embargo, tan criollo culturalmente, se enorgullece de serlo el colombiano como aquel que lo es por dictados de la sangre ancestral, considerándose Colombia uno de los países más hispánicos, no sólo por la sangre cultural que colma su espíritu neorenacentista, sino por el purismo de su lenguaje castizo con que se expresan, para hablar con énfasis y claridad, las voces múltiples de sus portavoces raciales.

  19. Professional Android Programming with Mono for Android and NETC#

    CERN Document Server

    McClure, Wallace B; Croft, John J; Dick, Jonathan; Hardy, Chris

    2012-01-01

    A one-of-a-kind book on Android application development with Mono for Android The wait is over! For the millions of .NET/C# developers who have been eagerly awaiting the book that will guide them through the white-hot field of Android application programming, this is the book. As the first guide to focus on Mono for Android, this must-have resource dives into writing applications against Mono with C# and compiling executables that run on the Android family of devices. Putting the proven Wrox Professional format into practice, the authors provide you with the knowledge you need to become a succ

  20. MONO FOR CROSS-PLATFORM CONTROL SYSTEM ENVIRONMENT

    International Nuclear Information System (INIS)

    Nishimura, Hiroshi; Timossi, Chris

    2006-01-01

    Mono is an independent implementation of the .NET Framework by Novell that runs on multiple operating systems (including Windows, Linux and Macintosh) and allows any .NET compatible application to run unmodified. For instance Mono can run programs with graphical user interfaces (GUI) developed with the C(number s ign) language on Windows with Visual Studio (a full port of WinForm for Mono is in progress). We present the results of tests we performed to evaluate the portability of our controls system .NET applications from MS Windows to Linux

  1. As principais alterações dermatológicas em pacientes obesos Major dermatological changes in obese patients

    Directory of Open Access Journals (Sweden)

    Rosimeri da Silva Castanho Mendonça

    2011-03-01

    Full Text Available INTRODUÇÃO: A obesidade é considerada grave doença crônica que vem atingindo proporções mundiais gerando transtornos sérios para a saúde pública. No Brasil, a prevalência desta doença denota aumento progressivo em relação ao número de pessoas com sobrepeso e/ou obesidade. Apesar disso, as manifestações dermatológicas da obesidade têm sido pouco estudadas. OBJETIVO: Abordar as dermatoses que mais acometem pacientes obesos e seu tratamento, principalmente na aplicação adequada da fisioterapia dermatofuncional. MÉTODO: Revisão da literatura, entre 2000 e 2010, de artigos indexados nas bases Medline/Pubmed, Scielo e Lilacs, livros e monografias das bibliotecas da Universidade de Fortaleza e Universidade Federal do Ceará, Fortaleza, CE, Brasil, cruzando os descritores obesidade, dermatose e fisioterapia. Foram reconhecidas como mais importantes as seguintes situações patológicas: estrias, celulite, acanthosis nigricans, acrocórdons, flacidez, úlcera e impetigo. Entre as formas de tratamento deuse destaque à atuação da fisioterapia dermatofuncional. CONCLUSÃO: O tratamento das dermatoses por meio da fisioterapia dermatofuncional é possível podendo trazer consigo resultados que satisfaçam a expectativa dos pacientes e proporcionando-lhes melhor qualidade de vida.INTRODUCTION: Obesity is a serious chronic disease that has reached global proportions causing problems to public health. In Brazil, the prevalence of this disease shows a progressive increase in the number of people with overweight or obesity. Nevertheless, the skin manifestations have not been well studied. OBJECTIVE: To analyse the dermatosis most affecting obese patients and its treatment, particularly in proper application of dermatological therapy. METHOD: Was made a literature review between 2000 and 2010 of articles published in Medline/ PubMed, SciELO and Lilacs, books and monographs of the libraries of the University of Fortaleza and the Federal

  2. Dark matter searches with a mono-Z′ jet

    International Nuclear Information System (INIS)

    Bai, Yang; Bourbeau, James; Lin, Tongyan

    2015-01-01

    We study collider signatures of a class of dark matter models with a GeV-scale dark Z ′ . At hadron colliders, the production of dark matter particles naturally leads to associated production of the Z ′ , which can appear as a narrow jet after it decays hadronically. Contrary to the usual mono-jet signal from initial state radiation, the final state radiation of dark matter can generate the signature of a mono-Z ′ jet plus missing transverse energy. Performing a jet-substructure analysis to tag the Z ′ jet, we show that these Z ′ jets can be distinguished from QCD jets at high significance. Compared to mono-jets, a dedicated search for mono-Z ′ jet events can lead to over an order of magnitude stronger bounds on the interpreted dark matter-nucleon scattering cross sections.

  3. New mono-organotin (IV) dithiocarbamate complexes

    International Nuclear Information System (INIS)

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim

    2014-01-01

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S 2 CNR′R″] 2 (R= Ph, CH 3 , R′ = CH 3 , C 2 H 5 , C 7 H 7 and R″ = C 2 H 5 , C 6 H 11 , iC 3 H 7 , C 7 H 7 ). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, 1 H, 13 C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(C N), ν(C S) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm −1 respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of N C S group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The 13 C NMR spectra showed an important shift for δ(N 13 CS 2 ) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S 2 CN(Et)(i−Pr)] 2 , MeSnCl[S 2 CN(Me)(Cy)] 2 and MeSnCl[S 2 CN(i−Pr)(CH 2 Ph)] 2 . All structures having a distorted octahedral geometry set by CClS 4 donor atom from the two chelating dithiocarbamate ligands

  4. Função pulmonar em doentes obesos submetidos a cirurgia bariátrica

    Directory of Open Access Journals (Sweden)

    C. Guimarães

    2012-05-01

    Full Text Available Resumo: A obesidade é considerada um problema de saúde pública da atualidade. Devido ao facto de alterar a relação entre pulmões, parede torácica e diafragma, a obesidade tem sido relacionada com alterações da função pulmonar. Em Portugal, existem dados muito limitados entre a relação da obesidade com a função pulmonar.O objetivo deste estudo foi avaliar as alterações da função respiratória nos doentes obesos mórbidos e o comportamento dos parâmetros obtidos nas provas funcionais respiratórias (PFR no pré e pós cirurgia bariátrica.Realizamos um estudo retrospectivo pré e pós cirurgia bariátrica em 36 doentes obesos mórbidos, com uma média de idades de 40,6 anos sendo 64% do sexo feminino e com um índice de massa corporal (IMC médio de 49,7 kg/m2. Todos os doentes foram avaliados clínica e funcionalmente antes da cirurgia bariátrica e após estabilização do peso na sequência deste procedimento tendo-se realizado espirometria, volumes pulmonares, difusão do monóxido de carbono (DLCO, pressões máximas respiratórias e gasometria arterial. Previamente à cirurgia a maioria mostrava alterações nas PFR, 34 doentes apresentavam uma diminuição da capacidade residual funcional (CRF dos quais 6 tinham síndrome restritiva. Apenas 2 doentes não expressavam qualquer alteração funcional ou gasométrica. Após a cirurgia bariátrica o IMC médio reduziu para 34 kg/m2 e verificou-se uma melhoria significativa de quase todos os parâmetros funcionais havendo resolução dos padrões restritivos, mantendo, contudo, ainda 13 doentes a CRF diminuída.Foi apenas encontrada correlação com significado estatístico entre a redução do IMC e o aumento da CRF (r = −0,371; p = 0,028.Este estudo sugere uma relação entre obesidade e restrição pulmonar e aponta para um

  5. Searching for Dark Matter in the Mono-Jet and Mono-Photon Channels with the ATLAS Detector

    CERN Document Server

    Ratti, Maria Giulia; Carminati, Leonardo

    This work presents searches for dark matter particles in the mono-jet and mono-photon final states using the data collected by the ATLAS experiment during 2015 and 2016. The thesis starts with an introduction to the basic concepts of the Standard Model, followed by a discussion of the dark matter problem and the WIMP hypothesis. The focus then shifts to the description of the experimental facilities to collect the data and reconstruct the collision events. Particular focus is put on the reconstruction and performance of the missing transverse momentum. After characterizing a few theoretical models predicting dark matter particles in the mono-photon and mono-jet final states, the searches in these two signatures are thoroughly discussed, with particular focus on the background estimation techniques. While no significant deviations from the Standard Model predictions are found, the results obtained by these searches further restrict the phase-space where the dark matter particles can lie.

  6. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    Full Text Available FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo Modelo de Avaliação da Homeostase (HOMA-RI: com resistência insulínica (RI n = 39 e sem resistência insulínica (NRI n = 27, e foram submetidos a uma intervenção interdisciplinar ao longo de um ano. A espessura mediointimal da artéria carótida comum (EMIC, e o tecido adiposo visceral e subcutâneo foram determinados por ultrassonografia. A composição corporal, pressão arterial, índice HOMA-RI, perfil lipídico e as concentrações de adipocinas [leptina, adiponectina, e inibidor do ativador do plasminogênio-1 (PAI-1] foram analisados antes e após a terapia. RESULTADOS: Ambos os grupos apresentaram melhoras significativas na composição corporal, estado inflamatório (redução da concentração de leptina e PAI 1; aumento de adiponectina plasmática e redução da EMIC. Apenas o grupo NRI mostrou correlação positiva entre as alterações na gordura visceral (∆Visceral e mudanças na EMIC (∆ EMIC (r = 0,42, p < 0,05. A análise por regressão linear simples revelou o ∆Visceral ser um preditor independente para a redução da EMIC nesse grupo (R2 ajustado = 0,14, p = 0,04. Os valores finais da EIMC permaneceram significativamente maiores no grupo RI, quando comparado com grupo NRI. CONCLUSÃO: A presença de resistência insulínica pode prejudicar mudanças na EMIC levando ao desenvolvimento precoce da aterosclerose em adolescentes obesos submetidos a uma intervenção interdisciplinar.

  7. Variabilidade da frequência cardíaca, lípides e capacidade física de crianças obesas e não-obesas Variabilidad de la frecuencia cardiaca, lípidos y capacidad física de niños obesos y no obesos Heart rate variability, blood lipids and physical capacity of obese and non-obese children

    Directory of Open Access Journals (Sweden)

    Mário Augusto Paschoal

    2009-09-01

    Full Text Available FUNDAMENTO: A obesidade pode afetar a modulação autonômica cardíaca, os lípides do sangue e a capacidade física. OBJETIVO: Estudar a interferência da obesidade sobre a variabilidade da frequência cardíaca (VFC, os lípides do sangue e a capacidade física de crianças obesas. MÉTODOS: Foram estudadas 30 crianças com idades entre 9 a 11 anos, divididas em dois grupos: a 15 crianças obesas (O com 10,2 ± 0,7 anos de idade e índice de massa corporal (IMC no percentil entre 95 e 97; b 15 crianças não-obesas (NO com 9,8 ± 0,7 anos de idade e IMC no percentil entre 5 e 85. Todas foram submetidas a avaliação antropométrica e clínica, análise da VFC ao repouso e a um protocolo de esforço (PE. Utilizaram-se testes não-paramétricos para comparar as variáveis entre os grupos, e o nível de significância aplicado foi de p FUNDAMENTO: La obesidad puede afectar la modulación autonómica cardiaca, los lípidos de la sangre y la capacidad física. OBJETIVO: Estudiar la interferencia de la obesidad sobre la variabilidad de la frecuencia cardiaca (VFC, los lípidos de la sangre y la capacidad física de niños obesos. MÉTODOS: Se estudiaron a 30 niños con edades entre 9 y 11 años, divididos en dos grupos: a 15 niños obesos (O con 10,2 ± 0,7 años de edad e índice de masa corporal (IMC en el percentil entre 95 y 97; b 15 niños no obesos (NO con 9,8 ± 0,7 años de edad e IMC en el percentil entre 5 y 85. Todos se sometieron a evaluación antropométrica y clínica, análisis de la VFC al reposo y a un protocolo de esfuerzo (PE. Se utilizaron pruebas no paramétricas para comparar las variables entre los grupos, y el nivel de significancia aplicado fue de p BACKGROUND: Obesity can affect the cardiac autonomic modulation, blood lipid levels and the physical capacity. OBJECTIVE: To study the effect of obesity on the heart rate variability (HRV, blood lipid levels and physical capacity of obese children. METHODS: Thirty children aged

  8. New mono-organotin (IV) dithiocarbamate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi (Malaysia)

    2014-09-03

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S{sub 2}CNR′R″]{sub 2} (R= Ph, CH{sub 3}, R′ = CH{sub 3}, C{sub 2}H{sub 5}, C{sub 7}H{sub 7} and R″ = C{sub 2}H{sub 5}, C{sub 6}H{sub 11}, iC{sub 3}H{sub 7}, C{sub 7}H{sub 7}). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, {sup 1}H, {sup 13}C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm{sup −1} respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The {sup 13}C NMR spectra showed an important shift for δ(N{sup 13}CS{sub 2}) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S{sub 2}CN(Et)(i−Pr)]{sub 2}, MeSnCl[S{sub 2}CN(Me)(Cy)]{sub 2} and MeSnCl[S{sub 2}CN(i−Pr)(CH{sub 2}Ph)]{sub 2}. All structures having a distorted octahedral geometry set by CClS{sub 4} donor atom from the two

  9. Síndrome metabólico en niños y adolescentes hipertensos obesos Metabolic syndrome in hypertensive and obese children and adolescents

    Directory of Open Access Journals (Sweden)

    Yudalvis Oquendo de la Cruz

    2010-12-01

    Full Text Available INTRODUCCIÓN. La combinación de hipertensión y obesidad en la infancia y la adolescencia incrementa el riesgo de un síndrome metabólico (SM en edades tempranas de la vida. El objetivo de este estudio fue determinar la presencia de SM en adolescentes hipertensos obesos y su relación con algunas variantes clínicas y bioquímicas. MÉTODOS. Se realizó un estudio descriptivo y prospectivo, con 152 niños y adolescentes hipertensos obesos, con edades entre 5 y 19 años, procedentes de la consulta de nefrología del Hospital Pediátrico Universitario «Juan Manuel Márquez». Se realizaron estudios de microalbuminuria, glucemia, insulina, colesterol total y triglicéridos en ayunas. RESULTADOS. Se encontró síndrome metabólico en el 35,5 % de los hipertensos obesos y fue más frecuente en el sexo masculino. Predominó la obesidad grave y 8 de cada 10 niños presentaron 3 criterios del síndrome. La prevalencia de cada uno de los componentes fue del 33,3 % en la alteración del metabolismo de la glucosa, del 100 % en la obesidad central e hipertensión arterial, del 51,8 % en la hipertrigliceridemia y del 13 % en el colesterol de lipoproteínas de alta densidad (HDL-C bajo. Casi la mitad de los pacientes tenían microalbuminuria. El 31,5 % de los sujetos estudiados presentó insulinorresistencia y en el 29,5 % de los casos se encontró hígado graso no alcohólico. CONCLUSIONES.Uno de cada 3 hipertensos obesos tenía síndrome metabólico, por lo que se recomienda continuar investigando sobre este síndrome en la infancia y la adolescencia.INTRODUCTION. The combination of high blood pressure and obesity in childhood increases the risk of metabolic syndrome (MS in early ages of life. The aim of present study was to determine the presence of MS in obese hypertensive adolescents and its relation to some clinical and biochemical variants. METHODS. A prospective and descriptive study was conducted in 152 obese children and adolescents aged 5 and

  10. Consumo alimentar e gasto energético em adolescentes obesos e eutróficos Food consumption and energy expenditure in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Camila Dayrell

    2009-12-01

    Full Text Available OBJETIVO: Comparar, entre adolescentes obesos e eutróficos, variáveis relacionadas ao consumo alimentar e ao gasto energético. MÉTODOS: Estudo transversal com 23 adolescentes recrutados em escolas e centros de recreação de São Paulo (SP, distribuídos em dois grupos: 11 obesos e 12 eutróficos. Foram avaliados: peso corporal, estatura, índice de massa corporal, circunferência da cintura, massa magra e massa gorda (estimados por bioimpedância elétrica, três recordatórios alimentares de 24 horas, estimativa do gasto energético diário a partir de três métodos (recordatórios de atividade física, fórmulas preditivas e calorimetria indireta, gasto energético de repouso e a potência aeróbia. RESULTADOS: O gasto energético diário dos obesos foi maior, porém a ingestão alimentar se assemelhou à dos eutróficos. Não foram encontradas diferenças no gasto energético de repouso entre os grupos, porém a potência aeróbia foi maior nos eutróficos. A dieta de ambos os grupos não foi considerada saudável, mas os obesos apresentaram menor consumo de vários alimentos considerados saudáveis, como hortaliças. Observou-se discrepância na análise do gasto energético diário, quando se adotaram diferentes métodos. CONCLUSÕES: Os adolescentes apresentaram padrão alimentar associado ao risco de obesidade e doenças crônicas. Mais estudos são necessários para identificar melhores métodos para avaliar seu gasto energético. É urgente a busca de estratégias de educação nutricional específicas para esse grupo etário.OBJECTIVE: To compare food consumption and energy expenditure between obese and non-obese adolescents. METHODS: This cross-sectional study comprised 23 adolescents recruited from schools and recreation centers from São Paulo (SP, Brazil, distributed in two groups: 11 obese and 12 non-obese. The following variables were analyzed: body weight, height, body mass index, waist circumference, fat and lean mass

  11. Validação de equações de predição da taxa metabólica basal em sujeitos eutróficos e obesos

    Directory of Open Access Journals (Sweden)

    Renata Lopes Krüger

    2014-12-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2015v17n1p73   Equações de predição para taxa metabólica basal (TMB são amplamente utilizadas para prescrição dietética, porém podem apresentar valores diferentes daqueles medidos por calorimetria indireta (CI, principalmente, em indivíduos obesos. O objetivo deste estudo foi verificar os valores de TMB por meio da CI em indivíduos obesos de grau I e eutróficos e comparar com os resultados obtidos pelas equações de predição, a fim de identificar se existe discrepância nos valores obtidos entre o medido pela CI e o estimado pelas equações. O estudo avaliou 40 homens entre 18 e 30 anos, sendo 20 eutróficos e 20 obesos grau I. Foi verificado o grau de concordância entre as equações e CI por meio da metodologia sugerida por Bland e Altman (1986. Os resultados mostram a variação entre os métodos de predição de -19,6% a -9,1%, quando comparadas a CI nos sujeitos obesos, e de -4,2% a 4,4% nos eutróficos. Em ambos os grupos, a equação que mais se aproxima da estimativa real é a de Miflin St. Jeor (1990, com -9,1% de diferença da CI nos sujeitos obesos e 0,9% nos eutróficos. Desta forma, o presente estudo indica a utilização da equação de Mifflin St. Jeor (1990 para estimar a TMB. Entretanto, é fundamental que se consiga medir a TMB de sujeitos obesos de maneira mais precisa e segura, para melhor conduzir a intervenção baseada em exercícios físicos e boa alimentação.

  12. Discrepâncias na imagem corporal e na dieta de obesos Self-discrepancy in body image and diet

    Directory of Open Access Journals (Sweden)

    Patrícia Kanno

    2008-08-01

    Full Text Available OBJETIVO: Este estudo avaliou a discrepância entre a imagem real e a imagem ideal de indivíduos obesos e procurou relacionar possíveis alterações no comportamento alimentar na busca desse corpo ideal. MÉTODOS: A amostra foi composta por 25 sujeitos, sendo 76% do sexo feminino e idade média de 39,24 (desviopadrão=5,01 anos. Dois instrumentos foram utilizados: a Escala de Aparência Física, cuja análise fatorial extraiu um único fator "Aparência Física" com precisão de α=0,74 para mulheres e α=0,73 para homens e o Questionário de Prioridade Alimentar elaborado para agrupar itens nas categorias que compõem a Pirâmide Alimentar. Foram realizados testes t pareados para comparar diferenças entre as imagens real e ideal e para comparar os comportamentos alimentares real e ideal. RESULTADOS: Os resultados apresentaram diferenças entre as imagens ideal e real, sendo a primeira representada de forma mais positiva que a última. Com relação ao comportamento alimentar, os resultados demonstraram diminuição no consumo de carnes e café preto e aumento no consumo de frutas e vegetais para atingir o corpo ideal. Porém, a amostra não mudaria os seus hábitos em relação ao consumo de cereais, laticínios, óleos e gorduras, doces e refrigerantes. CONCLUSÃO: Embora os resultados apresentem diferenças na percepção da imagem corporal, a amostra não mudaria os seus hábitos em relação às categorias do topo da pirâmide alimentar.OBJECTIVE: This study evaluated the discrepancy between actual and ideal body images of obese individuals and listed changes in the dietary behaviors used to achieve this ideal body image. METHODS: The sample was composed of 25 obese individuals with a mean age of 39.24 years (standard deviation=5.01 where 76% were females. Two instruments were used for this end: the Physical Appearance Scale whose factorial analysis extracted a single factor "Physical Appearance" with an accuracy of α=0.74 for women and

  13. Metallic Contact Formation for Molecular Electronics : Interactions between Vapor-Deposited Metals and Self-Assembled Monolayers of Conjugated Mono- and Dithiols

    NARCIS (Netherlands)

    Boer, Bert de; Frank, Martin M.; Chabal, Yves J.; Jiang, Weirong; Garfunkel, Eric; Bao, Zhenan

    2004-01-01

    We present grazing-incidence Fourier transform infrared and AFM data of Au, Al, and Ti vapor-deposited onto self-assembled monolayers (SAMs) of conjugated mono- and dithiols. SAMs of 4,4'''-dimercapto-p-quaterphenyl, 4,4''-dimercapto-p-terphenyl, and 4,4'-dimercapto-p-biphenyl have reactive thiols

  14. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2 Impact of participatory education on body mass index and blood glucose in obese type-2 diabetics

    Directory of Open Access Journals (Sweden)

    Carlos Enrique Cabrera-Pivaral

    2004-02-01

    Full Text Available La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos de pacientes diabéticos obesos. La intervención educativa-participativa se organizó mediante el proceso de reflexión-acción. Se efectuaron mediciones del IMC basal y mensuales durante los 9 meses de la intervención educativa. Los grupos fueron controlados tomando en cuenta edad y sexo. El análisis estadístico se efectuó con el estadígrafo de t de students con diferencia de media para grupos relacionados. El grupo control logra un valor promedio de IMC basal de 33.89 ± 1.96 y al final de 33.2 ± 2.15 (t: 22.4; p: 0.16, el grupo de experimento con valor inicial de 33.63 ± 2.12 y final de 31.54 ± 1.71 (t: 11.55; p = 0.003. La intervención educativa participativa contribuye a mejorar el nivel de IMC en los diabéticos obesos 2.Exogenous obesity increases morbidity and mortality risk and has been associated with nutritional habits, which in turn can be affected by health education. Health education aims to promote patient participation in achieving behavior change and healthy lifestyles. The objective of this study is to show the advantages of participatory education in the modification of body mass index (BMI in obese type-2 diabetics. A quasi-experimental study was performed with random allocation of two patient groups. The educational intervention was organized through a reflection-action process. BMI was measured at baseline and then monthly for 9 months during the intervention. The groups were analyzed by age and sex. Statistical

  15. Padrões alimentares de adolescentes obesos e diferentes repercussões metabólicas Dietary patterns of obese adolescents and different metabolic effects

    Directory of Open Access Journals (Sweden)

    Vera Regina Mello Dishchekenian

    2011-02-01

    Full Text Available OBJETIVO: Avaliar a associação de padrões alimentares com alterações metabólicas em adolescentes obesos. MÉTODOS: Estudo transversal envolvendo 76 estudantes (ambos os sexos, 14-19 anos, IMC³P95 e Tanner ³4 de escolas públicas da cidade de São Paulo, Brasil. Foram coletados dados antropométricos e bioquímicos, e aplicados questionários com informações sociodemográficas e registro alimentar de 4 dias, entre 2006 e 2007. Escores fatoriais foram obtidos na análise fatorial e, após ajustes, três padrões alimentares identificados foram associados a fatores de risco biológico por regressão linear múltipla. RESULTADOS: O padrão Tradicional (arroz e massas, feijões, carnes vermelhas, embutidos, óleos e doces foi positivamente associado com insulina, glicemia e triglicérides e negativamente associado com lipoproteína de alta densidade. O padrão Em Transição (peixe, aves, ovos, pães, manteiga, leite e derivados, hortaliças, frutas, sucos de frutas e açúcar refinado apresentou as mesmas associações, além de associação similar com a pressão arterial diastólica. O padrão Fast Food (cafeteria, hambúrguer, maionese, bolacha, bolos e tortas, chocolate e refrigerantes apresentou associação positiva com o colesterol, lipoproteína de baixa densidade e pressão arterial sistólica e diastólica, e associação negativa com insulina e lipoproteína de alta densidade. CONCLUSÃO: Os padrões Tradicional e Em transição apresentaram associações diferentes com o metabolismo lipídico e glicídico quando comparados com o padrão Fast Food. Os três padrões podem ser considerados obesogênicos, porém o padrão Fast Food pareceu ser o mais aterogênico e promotor de hipertensão arterial.OBJECTIVE: This study assessed the association between dietary patterns and metabolic changes in obese adolescents. METHODS: This was a cross-sectional study of 76 students (both genders, 14-19 years old, BMI³P95 and Tanner stage ³4

  16. Assessment of executive functions in obese individuals with binge eating disorder Avaliação de funções executivas em indivíduos obesos com transtorno da compulsão alimentar periódica

    Directory of Open Access Journals (Sweden)

    Duchesne Monica

    2010-12-01

    Full Text Available OBJECTIVE: The aim of this study was to assess executive functions of obese individuals with binge eating disorder. METHOD: Thirty-eight obese individuals with binge eating disorder were compared to thirty-eight obese controls without binge eating disorder in terms of their executive functions. All individuals were assessed using the following instruments: Digit Span, Trail Making Tests A and B, Stroop Test and the Wisconsin Card Sorting Test. In addition, four subtests from the Behavioral Assessment of the Dysexecutive Syndrome Battery were also used, namely the Zoo Map Test, the Modified Six Elements Test, the Action Program Test and the Rule Shift Cards Test. RESULTS: When compared to obese controls, obese individuals with binge eating disorder presented significant impairment in the following tests: Digit Span backward, Zoo Map Test, Modified Six Elements Test, and Action Program Test. Subjects with binge eating disorder also showed significant more set shifting and perseverative errors in the Wisconsin Card Sorting Test. In other measures such as the Digit Span Forward, the Trail Making Test, the Stroop Test and the Rule Shift Cards Test, obese subjects with binge eating disorder did not differ significantly from obese subjects without binge eating disorder. CONCLUSION: These results suggest that, in the present sample, obese individuals with binge eating disorder presented executive deficits, especially impairments relating to problem-solving, cognitive flexibility and working memory.OBJETIVO: O objetivo desse estudo foi avaliar as funções executivas de indivíduos obesos com transtorno da compulsão alimentar periódica. MÉTODO: Trinta e oito indivíduos obesos com transtorno da compulsão alimentar periódica foram comparados com 38 controles obesos sem transtorno da compulsão alimentar periódica em termos de suas funções executivas. Todos os indivíduos foram avaliados utilizando os seguintes instrumentos: Digit Span, Trail

  17. Steatosis Hepática en Niños y Adolecentes obesos: Asociación con adiposidad, lípidos, insulina y enzimas hepática

    OpenAIRE

    Camacho, Nolis; Guillén, Mayela; Gil, Giobely 1; Paoli, Mariela; Molina, Zarela; Cicchetti, Rosanna; Molina, Yudisay; Parra, Isabel

    2010-01-01

    Objetivos: Estudiar la frecuencia de presentación de esteatosis hepática (EH) en un grupo de niños y adolescentes obesos y su asociación con medidas antropométricas, niveles de lípidos sanguíneos, resistencia a la insulina y aminotransferasas. Métodos: Se incluyeron 22 niños y adolescentes obesos (IMC>pc97) entre 6 y 13 años de edad, con promedio de 9,28 ± 1,9 años, 59% de sexo masculino y 41% femenino. Se tomaron tensión arterial y medidas antropométricas, incluyendo cintura, y se calcularon...

  18. Efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I

    OpenAIRE

    Barbato,Kelly Biancardini Gomes; Martins,Rita de Cássia Vieira; Rodrigues,Maria de Lourdes Guimarães; Braga,José Ueleres; Francischetti,Emílio Antonio; Genelhu,Virginia

    2006-01-01

    OBJETIVO: Avaliar os efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I. MÉTODOS: Estudo observacional com 47 obesos grau I, média de idade de 33 anos, submetidos a orientação mensal quanto a dieta, exercício físico e comportamento alimentar, durante quatro meses. A pressão arterial, pelo método auscultatório, e a freqüência cardíaca, pelo método palpatório, foram avaliadas mensalmente, enquanto as seguintes variáveis (e respectivos ...

  19. Comparação entre a prevalência de transtornos mentais em pacientes obesos e com sobrepeso = Comparison between the prevalence of mental disorders in obese and overweight patients

    Directory of Open Access Journals (Sweden)

    Verdolin, Louise Deluiz

    2012-01-01

    Conclusões: Transtornos ansiosos foram mais prevalentes em pacientes obesos quando comparados aos pacientes com sobrepeso, alguns transtornos psíquicos associaram-se a obesidade grave e transtornos depressivos foram mais prevalentes em pacientes com circunferência da cintura muito aumentada. Estes resultados reafirmam a importância de considerar a abordagem psiquiátrica no manejo clínico da obesidade

  20. Resistencia a la insulina y cambios metabólicos en adultos obesos Insulin resistance and metabolic changes in obese adults

    Directory of Open Access Journals (Sweden)

    Raúl Fernández Regalado

    2011-08-01

    Full Text Available Introducción: la relación obesidad-resistencia insulínica-diabetes mellitus-hipertensión arterial adquiere cada día mayor importancia, por el papel cada vez más relevante de la obesidad en el desarrollo de cada una de ellas. Los obesos constituyen alrededor de 20 a 30 % de la población cubana, y esta enfermedad o condición patológica cada día se torna un problema más importante. Objetivo: estudiar la relación entre el grado de obesidad y la resistencia a la insulina en sujetos obesos, así como posibles cambios en el metabolismo lipídico y de compuestos nitrogenados. Métodos: se realizó un estudio observacional con individuos adultos obesos de ambos sexos entre 18 y 60 años de edad, atendidos en el Instituto Nacional de Endocrinología en el período comprendido entre 2006 y 2008. También fueron incluidos sujetos aparentemente sanos, normopesos, seleccionados en instituciones de salud de la atención primaria del municipio Plaza. Todos los sujetos (N=214 fueron clasificados en 4 grupos: normopesos (IMC entre 18,5 y 24,9, preobesos I (IMC entre 25 y 29,9, obeso grado II (IMC de 30 a 34,9, obeso grado III (IMC de 35 a 39,9. Además del examen clínico y mediciones antropométricas se tomó una muestra de sangre en ayunas para determinar en el suero los analitos siguientes: glucemia, insulina, colesterol total, triglicéridos, creatinina y ácido úrico. Se calculó además la resistencia a la insulina a partir de la glucemia y la cifra de insulinemia según el índice HOMA. Resultados: se observó una asociación significativa entre la circunferencia abdominal y el índice de masa corporal con el valor del índice resistencia a la insulina. Además, esta mostró una correlación significativa (pIntroduction: the relation obesity-insulin resistance-diabetes mellitus-high blood pressure is more and more significant due to the more relevant role of obesity in the development of each of them. The obese persons are about the 20 to 30

  1. Production of mono sugar from acid hydrolysis of seaweed | Jang ...

    African Journals Online (AJOL)

    ... the process conditions for the saccharification of macroalgae (seaweed) into mono sugar using the following parameters such as: Amount of biomass, catalyst concentration, temperature and reaction time. The major component of Ulva pertusa (green seaweed), Laminaria japonica (brown seaweed) and Gelidium amansii ...

  2. Mono- and binuclear complexes of low-valent zirconium

    NARCIS (Netherlands)

    Wielstra, IJtsen

    1990-01-01

    This thesis is a study on the synthesis and reactivity of low-valent zirconium. The investigation can be divided in two parts: the first describes the chemistry of mono-cyclopentadienyl Zr (II) complexes (Chapter II, III and IV), and the second describes some synthetic pathways successfully used for

  3. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

    2015-01-01

    for innovative and cost-effective design of Mono Bucket foundations. Established approach merges wind and wave load models, soil/structure interaction topics, structural optimization and installation/fabrication aspects, into software package with ability to perform optimal design of the individual foundations...

  4. Air quality in bedded mono-slope beef barns

    Science.gov (United States)

    Bedded mono-slope barns are becoming more common in the upper Midwest. Because these are new facilities, little research has been published regarding environmental quality, building management and animal performance in these facilities. A team of researchers from South Dakota State University, USDA ...

  5. Mono-fermentation of shea waste in anaerobic digesters - laboratory ...

    African Journals Online (AJOL)

    For the purpose of understanding the characteristics in performance of the shea waste and to provide the necessary input parameters towards the design of biogas plants, mono-fermentation as an option in anaerobic digestion for energy (methane) generation was investigated. Six horizontal reactors with a liquid volume of ...

  6. Doentes obesos: complicações respiratórias na unidade pós-anestésica

    Directory of Open Access Journals (Sweden)

    J. Mendonça

    2014-01-01

    Full Text Available Resumo: Introdução: A obesidade tem sido associada a eventos respiratórios e a maioria destes ocorrem no pós-operatório imediato na unidade pós-anestésica (UPA. O objetivo deste estudo foi avaliar o «outcome» e a incidência de eventos adversos respiratórios (ARE pós-operatórios em doentes com obesidade durante a sua permanência na UPA. Métodos: Estudo prospetivo caso-controlo com emparelhamento de 27 pares de adultos com obesidade e doentes com IMC  0,025. A análise multivariada identificou a obesidade e o bloqueio neuromuscular residual como fatores de risco independentes para a ocorrência de eventos respiratórios. A duração da estadia na UPA foi superior nos doentes obesos (120 min vs 84 min, p > 0,01. Conclusões: A incapacidade de respirar profundamente foi o ARE mais frequente no período pós-operatório imediato nos doentes obesos. A obesidade foi considerada um fator de risco independente para ocorrência de ARE na UPA. Os doentes obesos tiveram maior tempo de estadia na UPA mas não tiveram maior tempo de internamento hospitalar. Abstract: Introduction: Obesity has been associated with respiratory complications, and the majority of these complications occur in the Post-Anesthesia Care Unit (PACU. The aim of this study was to evaluate the outcome and incidence of adverse respiratory events (AREs in obese patients during their stay in the PACU Methods: We conducted a prospective control study that included 27 obese patients matched with an equal number of patients with body mass index (BMI < 30 (non-obese control group; the 2 groups of patients were similar in respect to gender distribution, age, and type of surgery and had been admitted into the PACU after elective surgery (May 2011. The AREs were identified during PACU stay. Descriptive analysis of variables was performed, and the Mann-Whitney U test, Chi-square test, or Fisher's exact test

  7. Mono- and di-n-butyl phosphates of some metals in spent nuclear fuel reprocessing

    Energy Technology Data Exchange (ETDEWEB)

    Solovkin, A.S.

    1982-01-01

    Results of investigations which have been carried out in the Soviet Union for the last 10 years on the determination of the composition, structure, conditions of the formation and solubility of mono- and di-n-butyl phosphates of metals (U/sup 6 +/, Pu/sup 4 +/, Pu/sup 3 +/, Th, Zr, Fe/sup 3 +/, Am, Al, rare-earth elements), which are important for the processes of irradiated nuclear fuel reprocessing, are presented. A conclusion is made that zirconium mono- and di-n-butyl phosphates are the least soluble in aqueous and organic solvents of all investigated compounds. FeA/sub 3/ and AmA/sub 3/ are weakly soluble in aqueous solutions. The other compounds are sufficiently soluble in moderately acidic aqueous solutions or in DBP and TBP with dilutents. The obtained results indicate at the similarity of zirconium and plutonium (4) chemical properties; thorium, in this respect, is not an analogue of plutonium (4). Possible structural formulas of the investigated compounds are considered.

  8. Adaptaciones al ejercicio físico en el perfil lipídico y la salud cardiovascular de obesos mórbidos.

    Science.gov (United States)

    Delgado-Floody, Pedro; Caamaño-Navarrete, Felipe; Jerez-Mayorga, Daniel; Martínez-Salazar, Cristian; García-Pinillos, Felipe; Latorre-Román, Pedro

    2017-01-01

    To assess the effects of a physical exercise program on the lipid profile, weight status and the cardiovascular health of obese candidates for bariatric surgery. 22 morbidly obese patients participated in a 6-month physical exercise program. 16 formed the adherent group (attendance ≥ 80%; age: 37.81 ± 11.90 years) and six the non-adherent group (attendance Salud

  9. Substituent effects on mono-substituted and poly-substituted nitriles; Efeitos dos substituintes em nitrilas mono- e polissubstituidas

    Energy Technology Data Exchange (ETDEWEB)

    Sofia, Raquel C.R.; Carneiro, Paulo I.B.; Rittner, Roberto [Universidade Estadual de Campinas, SP (Brazil). Inst. de Quimica; Fabi, Marino T [Rhodia S.A., Sao Paulo, SP (Brazil)

    1992-12-31

    This work studies various mono substituted aliphatic nitriles, Y C H{sub 2} (Y=H, F, Cl, Br, I, OMe, S Me, SEt{sub 2}, Me and Ph), and some reference nitriles (Y=Et, n-Pr, n-Bu, n-Am, n-Hex and n-Hept) 12 refs., 3 tabs.

  10. Biopolítica e confissão: cenas do grupo terapêutico com pacientes obesos Biopolitics and confession: scenes of group therapy with obese patients

    Directory of Open Access Journals (Sweden)

    Shirley Dias Gonçalves

    2012-01-01

    Full Text Available Este trabalho é baseado numa pesquisa realizada em um hospital público, especializado em cirurgia bariátrica na cidade de Fortaleza- CE e teve como objetivo investigar os discursos que circulam no grupo terapêutico realizado com pacientes diagnosticados obesos e como esses pacientes são subjetivados por esses discursos. A metodologia utilizada foi a observação participante do referido grupo composto por pacientes de ambos os sexos que estavam na fase pré e pós-operatória. Foram analisados dois dispositivos presentes no controle da obesidade: a biopolítica e a confissão. A cirurgia bariátrica funciona como uma estratégia biopolítica que incide sobre o corpo de uma população obesa e a confissão atua como tecnologia de si. Assim, esse trabalho buscou problematizar como o corpo obeso é demarcado por práticas de saber-poder que o constituem. Também se tratou de analisar as resistências ao discurso médico-científico sobre saúde, beleza e boa forma dos corpos.This work focuses on a research conducted in a Brazilian community hospital specialized in bariatric surgery (in Fortaleza, state of Ceará with the aim of analyzing therapy group discussions with obese patients and how the patients are subjected by these discussions. The research used participant observation methodology. The group was composed of both male and female patients in the pre- and post-operative periods. Two obesity control devices were analyzed: biopolitics and confession. Bariatric surgery acts as a biopolitical strategy on the obese population body, and confession works as a technology of the self. Therefore, this work questioned how knowledge-power practices determine an obese body. Additionally, the research analyzed the resistance to medical-scientific discussions regarding body health, beauty and fitness.

  11. Caracterización de niños y adolescentes obesos con síndrome metabólico

    Directory of Open Access Journals (Sweden)

    Yamileisy Santiago Martínez

    2012-03-01

    Full Text Available Introducción: el síndrome metabólico es más frecuente en niños y adolescentes con obesidad. Objetivo: determinar algunas características clínicas, antropométricas y de laboratorio en niños obesos con síndrome metabólico. Métodos: estudio transversal con 59 niños y adolescentes obesos con edades entre 2 y 14 años, seleccionados por muestreo aleatorio simple de 20 consultorios del municipio Urbano Noris, de Holguín, atendidos en abril-mayo de 2010. Las variables fueron: sexo, edad, peso, talla, índice de masa corporal, circunferencia abdominal, presión arterial, colesterol total, triglicéridos, glucemia, HDL-colesterol, LDL-colesterol, microalbuminuria y los índices colesterol total/HDL-colesterol y LDL-colesterol/HDL-colesterol, además, la presencia de hipertensión arterial y diabetes mellitus. Se empleó el análisis de varianza y la prueba c2 en SPSS y nivel de significación del 0,05. La pesquisa se realizó según los criterios cubanos basados en el Programa Nacional de Educación sobre el Colesterol de Estados Unidos. Resultados: la frecuencia del síndrome metabólico fue del 55,9 %. Estos pacientes presentaron valores superiores de la presión arterial, los triglicéridos, la glucemia, LDL-colesterol y de los índices aterogénicos y concentraciones más bajas de lipoproteínas de alta densidad, que el grupo sin síndrome metabólico (n= 26. Se encontró una asociación significativa entre el síndrome metabólico y la hipertensión arterial, no así con la microalbuminuria y la diabetes mellitus. No se encontraron diferencias de género. Conclusiones: es importante el diagnóstico del síndrome metabólico en niños y adolescentes para una mejor caracterización de este estado, y se recomienda una intervención basada en cambios de estilos de vida.

  12. Mono Lake sediments preserve a record of recent environmental change

    Science.gov (United States)

    Meixnerova, J.; Betts, M.; Westacott, S.; Ingalls, M.; Miller, L. G.; Sessions, A. L.; Trower, L.; Geobiology Course, A.

    2017-12-01

    Modern Mono Lake is a geochemically unique closed-basin, hypersaline soda lake. Since 1941, anthropogenic water diversions have decreased the lake's volume and water level, driving changes in water chemistry and ecology. Mono Lake sediments offer an opportunity to investigate the nature and extent of these changes. We analyzed a 70 cm sediment core from the center of Mono Lake recording the past 116 years of deposition. At the time of recovery, the entire core was dark green. 16S rRNA gene analysis indicated a sedimentary bacterial community dominated by Cyanobacteria. SEM imaging revealed abundant, well-preserved diatom frustules below 10 cm core depth, in contrast they are nearly absent above 10 cm depth. Fatty acid (FAME) biomarkers for diatoms and algal sterols were present throughout the core in varying concentrations. Phytol was exceptionally abundant in the core; ratios of phytol/C-18 FAME were commonly >200. The δ13Corg ranged between -17.5 and -20‰ in the lower 52 cm of the core while the upper part shows significant decrease of δ13Corg to -28‰. We interpret the shift in δ13Corg as an ecological transition from mainly diatoms in the lower core towards the green alga Picocystis, which is the main primary producer today and has a δ13Corg value of -32.5‰. The onset of this change dates back 23 years, which roughly coincides with the highest reported salinity, 88 g/L in 1995. We hypothesize that diatoms gradually became marginalized as a result of hypersaline conditions. We also observed a variety of trends that may be characterized as unique fingerprints of Mono Lake. The unusually high abundance of phytol was consistent with the core's pervasive green coloring and could potentially indicate a higher preservation potential of phytol under alkaline conditions. Throughout the core, δ15Norg fluctuated between +10 and +13‰. Such atypical enrichment in δ15Norg could be explained by NH4 dissociation and subsequent NH3 volatilization under high p

  13. Studies of mono-crystalline CVD diamond pixel detectors

    CERN Document Server

    Bartz, E; Atramentov, O; Yang, Z; Hall-Wilton, R; Schnetzer, S; Patel, R; Bugg, W; Hebda, P; Halyo, V; Hunt, A; Marlow, D; Steininger, H; Ryjov, V; Hits, D; Spanier, S; Pernicka, M; Johns, W; Doroshenko, J; Hollingsworth, M; Harrop, B; Farrow, C; Stone, R

    2011-01-01

    The Pixel Luminosity Telescope (PLT) is a dedicated luminosity monitor, presently under construction, for the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). It measures the particle flux in several three layered pixel diamond detectors that are aligned precisely with respect to each other and the beam direction. At a lower rate it also performs particle track position measurements. The PLTs mono-crystalline CVD diamonds are bump-bonded to the same readout chip used in the silicon pixel system in CMS. Mono-crystalline diamond detectors have many attributes that make them desirable for use in charged particle tracking in radiation hostile environments such as the LHC. In order to further characterize the applicability of diamond technology to charged particle tracking we performed several tests with particle beams that included a measurement of the intrinsic spatial resolution with a high resolution beam telescope. Published by Elsevier B.V.

  14. Humanos salvajes y monos altruistas. Reflexiones sobre Darwin

    Directory of Open Access Journals (Sweden)

    Jorge Martinez Contreras

    2009-10-01

    Full Text Available RESUMEN   Darwin propuso en 1871 que preferiría descender de un mono que de los “salvajes”. El mono es un babuino hamadryas que, en un relato de Brehm, salva a un infante de una jauría. Los “salvajes” son los fueguinos a los que visitó en los años 1830. ¿Por qué Darwin fue tan buen observador del comportamiento animal y por qué no dudo discernir en qué consistía la sociedad de cazadores-recolectores de los cuatro grupos de Tierra del Fuego?. Esto es lo que tratamos de dilucidar en este trabajo.   Palabras clave: Darwin, fueguinos, hamadryas, altruismo, egoísmo.

  15. Studies of mono-crystalline CVD diamond pixel detectors

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, W. [University of Tennessee, Knoxville (United States); Hollingsworth, M., E-mail: mhollin3@utk.edu [University of Tennessee, Knoxville (United States); Spanier, S.; Yang, Z. [University of Tennessee, Knoxville (United States); Bartz, E.; Doroshenko, J.; Hits, D.; Schnetzer, S.; Stone, R.; Atramentov, O.; Patel, R.; Barker, A. [Rutgers University, Piscataway (United States); Hall-Wilton, R.; Ryjov, V.; Farrow, C. [CERN, Geneva (Switzerland); Pernicka, M.; Steininger, H. [HEPHY, Vienna (Austria); Johns, W. [Vanderbilt University, Nashville (United States); Halyo, V.; Harrop, B. [Princeton University, Princeton (United States); and others

    2011-09-11

    The Pixel Luminosity Telescope (PLT) is a dedicated luminosity monitor, presently under construction, for the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). It measures the particle flux in several three layered pixel diamond detectors that are aligned precisely with respect to each other and the beam direction. At a lower rate it also performs particle track position measurements. The PLT's mono-crystalline CVD diamonds are bump-bonded to the same readout chip used in the silicon pixel system in CMS. Mono-crystalline diamond detectors have many attributes that make them desirable for use in charged particle tracking in radiation hostile environments such as the LHC. In order to further characterize the applicability of diamond technology to charged particle tracking we performed several tests with particle beams that included a measurement of the intrinsic spatial resolution with a high resolution beam telescope.

  16. Gamma spectra pictures using a digital plotter. Program MONO

    International Nuclear Information System (INIS)

    Los Arcos Merino, J.M.

    1978-01-01

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs

  17. Modification and performance evaluation of a mono-valve engine

    Science.gov (United States)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  18. Fatigue Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed thro...... of the natural period, damping ratio, current, stress Spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower.......In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability as well as systems reliability is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...

  19. Fatigue Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    1991-01-01

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed thro...... of the natural period, damping ratio, current, stress spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower.......In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability, as well as systems reliability, is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...

  20. Seasonality of cavitation and frost fatigue in Acer mono Maxim.

    Science.gov (United States)

    Zhang, Wen; Feng, Feng; Tyree, Melvin T

    2017-12-08

    Although cavitation is common in plants, it is unknown whether the cavitation resistance of xylem is seasonally constant or variable. We tested the changes in cavitation resistance of Acer mono before and after a controlled cavitation-refilling and freeze-thaw cycles for a whole year. Cavitation resistance was determined from 'vulnerability curves' showing the percent loss of conductivity versus xylem tension. Cavitation fatigue was defined as a reduction of cavitation resistance following a cavitation-refilling cycle, whereas frost fatigue was caused by a freeze-thaw cycle. A. mono developed seasonal changes in native embolisms; values were relatively high during winter but relatively low and constant throughout the growing season. Cavitation fatigue occurred and changed seasonally during the 12-month cycle; the greatest fatigue response occurred during summer and the weakest during winter, and the transitions occurred during spring and autumn. A. mono was highly resistant to frost damage during the relatively mild winter months; however, a quite different situation occurred during the growing season, as the seasonal trend of frost fatigue was strikingly similar to that of cavitation fatigue. Seasonality changes in cavitation resistance may be caused by seasonal changes in the mechanical properties of the pit membranes. © 2017 John Wiley & Sons Ltd.

  1. Post-middle Miocene Tuffs of Bodie Hills and Mono Basin, California: Paleomagnetic Reference Directions and Vertical Axis Rotation

    Science.gov (United States)

    Lindeman, J. R.; Pluhar, C. J.; Farner, M. J.

    2013-12-01

    The relative motions of the Pacific and North American plates about the Sierra Nevada-North American Euler pole is accommodated by dextral slip along the San Andreas Fault System (~75%) and the Walker Lane-Eastern California Shear Zone system of faults, east of the Sierra Nevada microplate (~25%). The Bodie Hills and Mono Basin regions lie within the Walker Lane and partially accommodate deformation by vertical axis rotation of up to 60o rotation since ~9.4 Ma. This region experienced recurrent eruptive events from mid to late Miocene, including John et al.'s (2012) ~12.05 Ma Tuff of Jack Springs (TJS) and Gilbert's (1968) 11.1 - 11.9 Ma 'latite ignimbrite' east of Mono Lake. Both tuffs can be identified by phenocrysts of sanidine and biotite in hand specimens, with TJS composed of a light-grey matrix and the latite ignimbrite composed of a grey-black matrix. Our paleomagnetic results show these units to both be normal polarity, with the latite ignimbrite exhibiting a shallow inclination. TJS's normal polarity is consistent with emplacement during subchron C5 An. 1n (12.014 - 12.116 Ma). The X-ray fluorescence analyses of fiamme from TJS in Bodie Hills and the latite ignimbrite located east of Mono Lake reveal them both to be rhyolites with the latite ignimbrite sharing elevated K composition seen in the slightly younger Stanislaus Group (9.0 - 10.2 Ma). We establish a paleomagnetic reference direction of D = 352.8o I = 42.7o α95 = 7.7o n = 5 sites (42 samples) for TJS in the Bodie Hills in a region hypothesized by Carlson (2012) to have experienced low rotation. Our reference for Gilbert's latite ignimbrite (at Cowtrack Mountain) is D = 352.9o I = 32.1o α95 = 4.7o. This reference locality is found on basement highland likely to have experienced less deformation then the nearby Mono Basin since ignimbrite emplacement. Paleomagnetic results from this latite ignimbrite suggests ~98.2o × 5.5o of clockwise vertical axis rotation of parts of eastern Mono Basin since

  2. Reconstruction of mono-vacancies in carbon nanotubes: Atomic relaxation vs. spin polarization

    Energy Technology Data Exchange (ETDEWEB)

    Berber, S. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571 (Japan)]. E-mail: berber@comas.frsc.tsukuba.ac.jp; Oshiyama, A. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571 (Japan)

    2006-04-01

    We have investigated the reconstruction of mono-vacancies in carbon nanotubes using density functional theory (DFT) geometry optimization and electronic structure calculations, employing a numerical basis set. We considered mono-vacancies in achiral nanotubes with diameter range {approx}4-9A. Contrary to previous tight-binding calculations, our results indicate that mono-vacancies could have several metastable geometries, confirming the previous plane-wave DFT results. Formation energy of mono-vacancies is 4.5-5.5eV, increasing with increasing tube diameter. Net magnetic moment decreases from ideal mono-vacancy value after reconstruction, reflecting the reduction of the number of dangling bonds. In spite of the existence of a dangling bond, ground state of mono-vacancies in semiconducting tubes have no spin polarization. Metallic carbon nanotubes show net magnetic moment for most stable structure of mono-vacancy, except for very small diameter tubes.

  3. Reconstruction of mono-vacancies in carbon nanotubes: Atomic relaxation vs. spin polarization

    International Nuclear Information System (INIS)

    Berber, S.; Oshiyama, A.

    2006-01-01

    We have investigated the reconstruction of mono-vacancies in carbon nanotubes using density functional theory (DFT) geometry optimization and electronic structure calculations, employing a numerical basis set. We considered mono-vacancies in achiral nanotubes with diameter range ∼4-9A. Contrary to previous tight-binding calculations, our results indicate that mono-vacancies could have several metastable geometries, confirming the previous plane-wave DFT results. Formation energy of mono-vacancies is 4.5-5.5eV, increasing with increasing tube diameter. Net magnetic moment decreases from ideal mono-vacancy value after reconstruction, reflecting the reduction of the number of dangling bonds. In spite of the existence of a dangling bond, ground state of mono-vacancies in semiconducting tubes have no spin polarization. Metallic carbon nanotubes show net magnetic moment for most stable structure of mono-vacancy, except for very small diameter tubes

  4. Kinetics of aluminum and sulfate release from forest soil by mono- and diprotic aliphatic acids

    Energy Technology Data Exchange (ETDEWEB)

    Evans, A. Jr.; Zelazny, L.W. (Virginia Polytechnic Institute and State Univ., Blacksburg (USA))

    1990-06-01

    A batch equilibration study evaluated the influence of naturally occurring low-molecular-weight mono- and diprotic aliphatic acids on the rate of Al and SO{sub 4}{sup 2{minus}} release in a Cecil soil (Typic Hapludult). The authors adjusted the pH of the organic acids (OAs) and of the soil suspension (3.8% w/w) to pH 4.0 and allowed them to equilibrate thermally before the experiment. After rapid addition of OAs to the soil suspension, they took solution samples at various time intervals and analyzed for Al, SO{sub 4}{sup 2{minus}}, and OA concentration. The initial concentration of OA in suspension was 1 {times} 10{sup {minus}5} mol liter{sup {minus}1}. Both Al and SO{sub 4}{sup 2{minus}} release followed pseudo-first-order kinetics, whereas OA adsorption obeyed simple first-order kinetics. The rate of Al release (k{sub 1}) was more rapid for the diprotic OA treatment (20.4 {times} 10{sup {minus}8} mol s{sup {minus}1}), as was SO{sub 4}{sup 2{minus}} release (1.63 {times} 10{sup {minus}8} mol s{sup {minus}1}), compared to the monoprotic OA treatment. The rate of Al release varied inversely with OA chain length and the distance between -COOH functional groups. The addition of substituent -OH groups between the -COOH groups further reduced K{sub 1}. A similar trend was observed for the rate of SO{sub 4}{sup 2{minus}} release (k{sub 1}) into solution. Monoprotic OAs were more rapidly adsorbed to the particle surfaces than were diprotic OAs. The authors postulate that removal of Al and SO{sub 4}{sup 2{minus}} from solution occurs via selective mineral precipitation.

  5. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Directory of Open Access Journals (Sweden)

    Chunping Liu

    Full Text Available Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE, whereas it has a scattered and patchy distribution in South China (SC. In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM. Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278 among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  6. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Science.gov (United States)

    Liu, Chunping; Tsuda, Yoshiaki; Shen, Hailong; Hu, Lijiang; Saito, Yoko; Ide, Yuji

    2014-01-01

    Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE), whereas it has a scattered and patchy distribution in South China (SC). In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM). Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278) among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  7. Genetic Structure and Hierarchical Population Divergence History of Acer mono var. mono in South and Northeast China

    Science.gov (United States)

    Shen, Hailong; Hu, Lijiang; Saito, Yoko; Ide, Yuji

    2014-01-01

    Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE), whereas it has a scattered and patchy distribution in South China (SC). In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM). Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species’ evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST = 0.073; G′ST = 0.278) among all populations, but significantly higher in the SC group than the NE group, mirroring the species’ more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study. PMID:24498039

  8. Gamma spectra pictures using a digital plotter. Program MONO; Representacion de Espectros directos mediante un trazado digital. Prograa MONO

    Energy Technology Data Exchange (ETDEWEB)

    Los Arcos, J M

    1978-07-01

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs.

  9. Beneficios de la terapia cognitivo-conductual y la presoterapia en pacientes obesos: ensayo clínico aleatorizado Benefits of cognitive behavior therapy and acupressure therapy in obese patients: a randomized clinical trial

    OpenAIRE

    V. Torres; A. Mª Castro Sánchez; G. A. Matarán Peñarocha; I. Lara Palomo; Mª E. Aguilar Ferrándiz; C. Moreno Lorenzo

    2011-01-01

    Objetivo: el objetivo del presente trabajo fue analizar la modificación de los hábitos de vida en pacientes obesos mediante la terapia cognitivo-conductual administrada conjuntamente con la presoterapia. Métodos: Se realizó un estudio experimental con grupo control placebo. Se asignaron de forma aleatoria 40 pacientes a grupo de intervención (terapia cognitivo-conductual + presoterapia) y a grupo control (sesiones informativas). La dimensión de estudio fue la administración de un cuestionario...

  10. Caracterización del cariotipo del mono aullador colorado Alouatta seniculus que habita en Colombia

    Directory of Open Access Journals (Sweden)

    Torres Olga María

    2001-12-01

    Full Text Available Presentamos cariotipos con bandas Q, G, R Y C del mono aullador colorado de Colombia, con base en el análisis de los cariotipos de 12 ejemplares cautivos y la reevaluación de los cariotipos de bandas Q de un macho y de una hembra publicados (Yunis et al. 1976. Reinterpretamos el mecanismo cromosómico de determinación del sexo y la morfología del cromosoma X de Alouatta seniculus seniculus. Los resultados indican que el cromosoma X es un metacéntrico de tamaño medio (4.85 % TCL similar al cromosoma X de otros primates de los géneros Cebus, Aotus y Ateles estudiados hasta la fecha, así como al cromosoma X humano. Además, los machos portan una translocación entre el cromosoma Y y el autosoma 3, demostrando un mecanismo cromosómico de  determinación del sexo XIXI X2X2 IXIX2 YIY2, diferente del convencional XX I XV. Todos los animales estudiados presentaron un número diploide de 44.This paper presents Q- G- R- and C-bands karyotypes ofred howler from Colombia, based on analyses of karyotypes oftwelve caught specimens besides a female and a male Q banding karyotypes (Yunis et al. 1976 reevaluated. We reappraisal X chromosome morphology and sex determination chromosome mechanism of Alouatta seniculus seniculus. This work shows X chromosome is a nearly metacentric médium sized chromosome (4.85 %TCL, similar to other primates X chromosome from Cebus, Aotus and Ateles genus up to now studied, as well as human X chromosome. Further in males, Y chromosome undergone a translocation onto autosome 3, named X1X2Y1Y2• Al! specimens studied shows 44 chromosomes diploid number.

  11. Metabolic syndrome in obese adolescents: what is enough? Síndrome metabólica em adolescentes obesos: o que é suficiente?

    Directory of Open Access Journals (Sweden)

    Leticia Esposito Sewaybricker

    2013-02-01

    Full Text Available OBJECTIVE: To study the agreement among three distinct criteria for metabolic syndrome (MS adapted to adolescents, and to identify associated factors for MS. METHODS: Cross-sectional study with 65 obese subjects aged 10 to 18 years, attended to at the Outpatient Clinic for Obese Children and Adolescents at the Clinical Hospital of the Universidade Estadual de Campinas (Unicamp. MS was defined using the criteria of the World Health Organization (WHO, the International Diabetes Federation (IDF, and the Adult Treatment Panel III (ATP III. Clinical, anthropometrical, and laboratorial data were associated to MS. RESULTS: From the 65 subjects, none had MS according to the WHO criteria, while 18 were diagnosed with MS (27.6% according to the IDF, and 19 (29.2% according to the ATP III. Agreement between IDF and ATP III was excellent (kappa 81%. In this study, puberty and triglycerides levels showed significant statistical difference when comparing subjects with and without MS, the first for ATP III (p = 0.03, and the second for IDF (p = 0.005 and ATP III (p = 0.001 criteria. CONCLUSION: The WHO criteria does not seem to be adequate for adolescents. IDF and ATP III criteria had an excellent agreement. Puberty and triglycerides were associated with MS.OBJETIVO: Avaliar a correlação de três critérios de síndrome metabólica (SM para adolescentes e identificar fatores associados. MÉTODOS: Estudo transversal com 65 pacientes obesos entre 10 e 18 anos do Ambulatório de Crianças e Adolescentes Obesos do HC-Unicamp. SM foi definida de acordo com a Organização Mundial da Saúde (OMS, International Diabetes Federation (IDF e Adult Treatment Panel III (ATP III. Buscaram-se fatores associados a SM em dados clínicos, antropométricos e laboratoriais. RESULTADOS: Dos 65 pacientes, nenhum foi diagnosticado como SM pela OMS, sendo 18 (27.6% pelo IDF e 19 (29.2% pelo ATP III. A correlação entre IDF e ATP III foi excelente (kappa 81%. Neste estudo, a

  12. High pressure structural phase transition of neodymium mono pnictides

    International Nuclear Information System (INIS)

    Pagare, Gitanjali; Ojha, P.; Sanyal, S.P.; Aynyas, Mahendra

    2007-01-01

    We have investigated theoretically the high-pressure structural phase transition of two neodymium mono NdX (X=As, Sb) using an interionic potential theory with necessary modification to include the effect of Coulomb screening by the delocalized f electrons of Nd ion. These compounds exhibits first order crystallographic phase transition from their NaCl (B 1 ) phase to body centered tetragonal (BCT) at 27 GPa and 15.3 GPa respectively. We also calculated the Nd-Nd distance as a function of pressure. (author)

  13. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl ...

    Science.gov (United States)

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of EGBE that will appear on the Integrated Risk Information System (IRIS) database.

  14. Transient Monotonic and Cyclic Load Effects on Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Nielsen, Søren Dam

    Today, 80 % of all European offshore wind turbines are installed on monopiles. A cost-effective alternative to the monopile is the mono bucket foundation. For an offshore wind turbine foundation in open seas, the dominant load is often coming from waves. During storms, large waves are formed...... the foundation is sucked to the seabed, creating extra capacity during the impact. Over the life-time of an offshore wind turbine foundation will be hit by millions of waves. Each wave might lead to a permanent rotation of the foundation. Therefore, it is important to be able to estimate the total deformation...

  15. Crenças e influências sobre dietas de emagrecimento entre obesos de baixa renda Beliefs and influences on weight loss diets among low-income obese individuals

    Directory of Open Access Journals (Sweden)

    Ana Paula Rodrigues Cavalcanti

    2007-12-01

    Full Text Available A obesidade tornou-se uma epidemia carente de controle imediato, principalmente entre pobres, mulheres e pessoas de baixa escolaridade. A OMS solicita e vários estudos corroboram que estudos esclarecedores sobre os comportamentos psicológicos e sociais interferentes na aderência terapêutica aos regimes devem ser encorajados. Este estudo usou a Teoria da Ação Racional - TAR, de M. Fishbein, em Psicologia Social, e comparou duas séries de entrevistas abertas (em 2001 e 2005 que eliciaram as crenças positivas (vantagens e negativas (desvantagens sobre fazer dieta entre obesos de baixa renda de João Pessoa, Paraíba, além dos referentes (pessoas de opinião influente destes pacientes quanto a segui-la. Os resultados de 2001 foram corroborados em 2005, revelando o medo das doenças relacionadas à obesidade e a vontade de sentir mais saúde e leveza de corpo. Mães, filhos e principalmente o cônjuge aparecem como apoiadores do regime. Ressaltou-se que não bastaria força de vontade, mas também reflexão e construção de habilidades de controle, apropriação e modificação das condições de vida. Preocupações estéticas não foram prioritárias. Estas informações podem fomentar melhores resultados na aderência terapêutica.Obesity has become an epidemic that requires immediate control, mainly among the poor, particularly women and the less educated. The WHO requests and several studies confirm that support is needed for research projects examining psychological and social behavior that hampers compliance with weight loss diets. This paper uses the Theory of Reasoned Action (TRA of M. Fishbein (1975 in social psychology, comparing two series of open interviews (conducted in 2001 and 2005 that disclosed positive (advantageous and negative (harmful beliefs about weight loss diets among low-income obese patients in João Pessoa, Paraíba State, as well as their guides (people of influential opinion on following their diets. The 2001

  16. Consumo de productos alimenticios dietéticos en niños diabéticos y obesos.

    OpenAIRE

    Borrello, Carolina

    2009-01-01

    Los seres humanos nacen con la preferencia hacia el sabor dulce y en ciertas ocasiones es necesario limitar el consumo de azúcares como en el control de peso, en prevención de caries o en personas diabéticas, para estos casos la industria ofrece una variedad de edulcorantes y productos dietéticos endulzados con ellos. Las tendencias actuales en la alimentación, llevan al hombre a un mayor consumo de alimentos concentrados en azúcares refinados y grasas, siendo la obesidad, c...

  17. Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: solution and biodistribution studies.

    Science.gov (United States)

    Chaves, Sílvia; Dron, Paul I; Danalache, Florina A; Sacoto, Diana; Gano, Lurdes; Santos, M Amélia

    2009-11-01

    Taking into account the recognized interest of a poly-pharmacological strategy in chelation therapy, a study of aluminium combined chelation based on 3-hydroxy-4-pyridinone (3,4-HP) compounds with complementary properties, associated to different denticity, size and extrafunctionality, is presented herein. In particular, Al-chelation has been explored, using a tetradentate IDA bis-(3,4-HP) ligand, L, and two N-glycosyl mono-(3,4-HP) derivatives (A or B). Combined complexation studies with the tetradentate and the most promising bidentate ligand (A) evidenced the formation of ternary complexes with high thermodynamic stability (Al-L-A) being the predominant species at physiological pH. In vivo studies on the ability for radiotracer ((67)Ga) removal from loaded mice, as a model of aluminium accumulation in body, have shown that the simultaneous administration to (67)Ga-loaded mice of a mono- and a bis-(3,4-HP) chelator (e.g. A and L) leads to a rapid metal elimination from main organs and whole animal model. This may be rationalized by coadjuvation and eventual synergistic effects, due to complementary accessibility of the chelators to different cellular compartments.

  18. MonoSLAM: real-time single camera SLAM.

    Science.gov (United States)

    Davison, Andrew J; Reid, Ian D; Molton, Nicholas D; Stasse, Olivier

    2007-06-01

    We present a real-time algorithm which can recover the 3D trajectory of a monocular camera, moving rapidly through a previously unknown scene. Our system, which we dub MonoSLAM, is the first successful application of the SLAM methodology from mobile robotics to the "pure vision" domain of a single uncontrolled camera, achieving real time but drift-free performance inaccessible to Structure from Motion approaches. The core of the approach is the online creation of a sparse but persistent map of natural landmarks within a probabilistic framework. Our key novel contributions include an active approach to mapping and measurement, the use of a general motion model for smooth camera movement, and solutions for monocular feature initialization and feature orientation estimation. Together, these add up to an extremely efficient and robust algorithm which runs at 30 Hz with standard PC and camera hardware. This work extends the range of robotic systems in which SLAM can be usefully applied, but also opens up new areas. We present applications of MonoSLAM to real-time 3D localization and mapping for a high-performance full-size humanoid robot and live augmented reality with a hand-held camera.

  19. Biosynthesis and Degradation of Mono-, Oligo-, and Polysaccharides: Introduction

    Science.gov (United States)

    Wilson, Iain B. H.

    Glycomolecules, whether they be mono-, oligo-, or polysaccharides or simple glycosides, are—as any biological molecules—the products of biosynthetic processes; on the other hand, at the end of their lifespan, they are also subject to degradation. The beginning point, biochemically, is the fixation of carbon by photosynthesis; subsequent metabolism in plants and other organisms results in the generation of the various monosaccharides. These must be activated—typically as nucleotide sugars or lipid-phosphosugars—before transfer by glycosyltransferases can take place in order to produce the wide variety of oligo- and polysaccharides seen in Nature; complicated remodelling processes may take place—depending on the pathway—which result in partial trimming of a precursor by glycosidases prior to the addition of further monosaccharide units. Upon completion of the 'life' of a glycoconjugate, glycosidases will degrade the macromolecule finally into monosaccharide units which can be metabolized or salvaged for incorporation into new glycan chains. In modern glycoscience, a wide variety of methods—genetic, biochemical, analytical—are being employed in order to understand these various pathways and to place them within their biological and medical context. In this chapter, these processes and relevant concepts and methods are introduced, prior to elaboration in the subsequent more specialized chapters on biosynthesis and degradation of mono-, oligo-, and polysaccharides.

  20. Synthesis, characterization and properties of a glycol-coordinated ε-Keggin-type Al13 chloride

    KAUST Repository

    Gu, Bin; Sun, Chenglin; Fettinger, James C.; Casey, William H.; Dikhtiarenko, Alla; Gascon, Jorge; Koichumanova, Kamila; Babu Sai Sankar Gupta, Karthick; Jan Heeres, Hero; He, Songbo

    2018-01-01

    Herein we present the first example of a glycol-coordinated ε-Keggin Al13 chloride (gl-ε-Al13), which is the first chelated version since discovery of Al13 in 1960. The molecular structure consists of [AlO4Al12(OH)12(OC2H4OH)12]Cl7·H2O units with chelating mono-anionic ethylene glycol units replacing one bridging and one terminal oxygen site.

  1. Synthesis, characterization and properties of a glycol-coordinated ε-Keggin-type Al13 chloride

    KAUST Repository

    Gu, Bin

    2018-03-29

    Herein we present the first example of a glycol-coordinated ε-Keggin Al13 chloride (gl-ε-Al13), which is the first chelated version since discovery of Al13 in 1960. The molecular structure consists of [AlO4Al12(OH)12(OC2H4OH)12]Cl7·H2O units with chelating mono-anionic ethylene glycol units replacing one bridging and one terminal oxygen site.

  2. Rare earth element and uranium-thorium variations in tufa deposits from the Mono Basin, CA

    Science.gov (United States)

    Wilcox, E. S.; Tomascak, P. B.; Hemming, N.; Hemming, S. R.; Rasbury, T.; Stine, S.; Zimmerman, S. R.

    2009-12-01

    Samples of fossil tufa deposits from several localities in the Mono Basin, eastern California, were analyzed for trace element concentrations in order to better understand changes in lake composition in the past. These deposits were formed during the last glacial cycle, mostly during deglaciation (Benson et al., 1990, PPP). Three elevations are represented by the analyses. Samples from near Highway 167 were sampled between 2063 and 2069 m asl. Samples from near Thompson Road were sampled between 2015 and 2021 m. One layered mound was sampled at 1955 m. Concentrations of the lanthanide rare earth elements (REE), in particular the heavy/light (HREE/LREE) distributions, have been shown to be sensitive to alkalinity in modern saline lakes (e.g., Johannesson et al., 1994, GRL, 21, 773-776), and the same has been suggested for U/Th (Anderson et al., 1982, Science, 216, 514-516). Holocene to near-modern tufa towers exist in shallow water and around the current shoreline (1945 m). Tufa towers above 2000 m include a characteristic morphology termed thinolite, interpreted to represent pseudomorphs after the very cold water mineral ikaite. Most lower elevation towers do not have the thinolite morphology, but some layered tufa mounds at low elevations include several layers of thinolite, such as the one sampled for this project. Analyses were made on millimeter-scale bulk samples from tufa towers. Measurements were made on sample solutions with a Varian 820MS quadrupole ICP-MS. Mono Basin tufa samples have total REE concentrations ranging from 0.029 to 0.77 times average shales. Samples have flat to moderately HREE-enriched shale-normalized patterns with limited overall variability ([La/Lu]SN of 1.8 to 9.6) but with some variability in the slope of the HREE portion of the patterns. Tufa towers sampled from three elevations have (Gd/Lu)SN of 0.40 to 1.5. The REE patterns of most samples have small positive Ce anomalies, but a minority of samples, all from the layered tufa mound

  3. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial Alteraciones vasculares en ratones obesos por dieta rica en grasa: papel de la vía L-arginina/NO endotelial Vascular alterations in high-fat diet-obese rats: role of Endothelial L-arginine/NO Pathway

    Directory of Open Access Journals (Sweden)

    Thiago Bruder Nascimento

    2011-07-01

    Full Text Available FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C e obeso (OB, ratos sob dieta rica em gordura por 30 semanas. Após 30 semanas, foram registrados o peso corporal, índice de adiposidade, pressão arterial e perfis metabólicos e endócrinos dos animais. Foram obtidas curvas para noradrelanina na ausência e presença de inibidor de óxido nítrico sintase (L-NAME, 3x10-4M em aorta torácica intacta e com desnudamento em ratos C e OB. RESULTADOS: As medidas de peso corporal, índice de adiposidade, leptina e insulina aumentaram nos ratos OB, enquanto a pressão arterial permaneceu inalterada. A obesidade também produziu tolerância à glicose e resistência à insulina. A reatividade à noradrenalina da aorta intacta foi similar em ratos C e OB. A presença de L-NAME produziu um aumento similar nas respostas máximas, mas um desvio maior à esquerda das respostas nas aortas intactas dos ratos C em relação aos ratos OB [EC50 (x10-7M: C = 1,84 (0,83-4,07, O = 2,49 (1,41-4,38; presença de L-NAME C = 0,02 (0,01-0,04*, O = 0,21 (0,11-0,40*†,*p FUNDAMENTO: Los mecanismos subyacentes a las anormalidades vasculares en la obesidad todavía no están completamente aclarados. OBJETIVO: Se evaluó la vía del óxido nítrico/L-arginina en la respuesta vascular de ratones obesos por dieta rica en grasa, concentrándonos en las células endoteliales y en el músculo liso. MÉTODOS: Ratones con 30 días de vida que fueron divididos en 2 grupos: control (C y obeso (OB, ratones bajo dieta rica en grasa durante 30 semanas. Después de 30 semanas, fueron registrados el peso corporal, el índice de adiposidad, la presión arterial y los

  4. Influência da mono-hidrogenação da fração C5 na síntese do TAME usando Amberlyst 15 como catalisador Influence of mono-hydrogenation of C5 cut on the synthesis of TAME using Amberlyst 15

    Directory of Open Access Journals (Sweden)

    Gilberto da Cunha Gonçalves

    2001-05-01

    Full Text Available No presente trabalho, foi estudada a síntese do TAME, em fase líquida, a partir de uma fração C5 e metanol, utilizando Amberlyst 15 como catalisador. A fração C5 utilizada possui uma diolefina, que tem uma alta tendência à formação de gomas e um alto teor de mono-olefinas. Deste modo, o objetivo deste trabalho foi avaliar o efeito da mono-hidrogenação da fração C5 na síntese do TAME. A hidrogenação foi feita a 80oC e 10 kgf/cm2 de H2, usando um catalisador 0,3% Pt/Al2O3. A diolefina foi totalmente hidrogenada e o teor de mono-olefinas significativamente reduzido sem um decréscimo apreciável no teor de isoamilenos reativos. A eterificação foi feita em um reator tipo batelada de 250 mL, com agitação magnética. A temperatura foi variada na faixa de 50 a 90oC, com uma pressão de 10 kgf/cm2 e razão molar isoamileno/metanol de aproximadamente um. Os produtos de reação foram analisados por cromatografia gasosa. A conversão total observada foi aproximadamente a mesma para o os cortes original e mono-hidrogenado. Entretanto, os produtos obtidos utilizando a fração C5 original apresentaram cheiro forte e coloração, mesmos para os testes a temperaturas mais baixas, que são características da formação de gomas. Por outro lado, quando a fração mono-hidrogenada foi usada na eterificação, o cheiro forte e coloração não foram observados. Portanto, a mono-hidrogenação da fração C5 contendo os isoamilenos reativos é necessária para que o TAME produzido na reação de eterificação possa ser adicionado à gasolinaTAME was synthesized in liquid phase from refinery C5 cut and methanol using Amberlyst 15 as catalyst. The C5 stream contains mainly mono-olefins and, in a less amount, a diolefin, which have a high gum formation tendency. The main purpose of this research was to evaluate the effect of mono-hydrogenation of C5 cut on TAME synthesis. The hydrogenation step was carried out at 80 oC and 10 kgf/cm2 of H2

  5. Dynamics of biogeochemical sulfur cycling in Mono Lake

    Science.gov (United States)

    Phillips, A. A.; Fairbanks, D.; Wells, M.; Fullerton, K. M.; Bao, R.; Johnson, H.; Speth, D. R.; Stamps, B. W.; Miller, L.; Sessions, A. L.

    2017-12-01

    Mono Lake, California is a closed-basin soda lake (pH 9.8) with high sulfate (120mM), and is an ideal natural laboratory for studying microbial sulfur cycling. Mono Lake is typically thermally stratified in summer while mixing completely in winter. However, large snowmelt inputs may induce salinity stratification that persists for up to five years, causing meromixis. During the California drought of 2014-16, the lake has mixed thoroughly each winter, but the abundant 2017 snowmelt may usher in a multi-year stratification. This natural experiment provides an opportunity to investigate the temporal relationship between microbial sulfur cycling and lake biogeochemistry. We analyzed water samples from five depths at two stations in May of 2017, before the onset of meromixis. Water column sulfate isotope values were generally constant with depth, centering at a δ34SVCDT of 17.39 ± 0.06‰. Organic sulfur isotopes were consistently lighter than lake sulfate, with a δ34SVCDT of 15.59 ± 0.56‰. This significant offset between organic and inorganic sulfur contradicts the minimal isotope effect associated with sulfate assimilation. Sediment push core organic values were further depleted, ranging between δ34SVCDT of -8.94‰ and +0.23‰, implying rapid turnover of Mono Lake sulfur pools. Both lipid biomarkers and 16S rRNA gene amplicons identify Picocystis salinarum, a unicellular green alga, as the dominant member of the microbial community. However, bacterial biomarkers and 16S rRNA genes point to microbes capable of sulfur cycling. We found that dsrA increased with depth (R2 = 0.9008, p reducers and sulfide oxidizers after >1 year of stratification. We saw no evidence in May of 2017 of sulfate reducing bacteria across the oxycline. Additionally, no sulfide was detectable in lake bottom waters despite oxygen below 6.25 µM. Preliminary results suggest a dynamic interplay between sulfide oxidation, sulfate reduction, and the onset of lake stratification. Additional

  6. Uso de dexmedetomidina em pacientes obesos mórbidos submetidos a gastroplastia: estabilidade cardiovascular e consumo de anestésicos venosos. Estudo retrospectivo Uso de dexmedetomidina en pacientes obesos mórbidos sometidos a gastroplastia: estabilidad cardiovascular y consumo de anestésicos venosos. Estudio retrospectivo Dexmedetomidine in morbid obese patients undergoing gastroplasty: cardiovascular stability and consumption of intravenous anesthetics. A retrospective study

    Directory of Open Access Journals (Sweden)

    Luiz Piccinini Filho

    2006-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A utilização de agentes anestésicos potentes e de curta duração é fundamental em pacientes submetidos à intervenção cirúrgica bariátrica. A dexmedetomidina, agonista alfa 2-adrenérgico, surgiu como uma opção adjuvante da técnica de anestesia venosa. O objetivo desta pesquisa foi avaliar a eficácia da dexmedetomidina associada à anestesia venosa, em pacientes obesos mórbidos, submetidos a gastroplastia. MÉTODO: Análise retrospectiva, de pacientes portadores de obesidade mórbida, submetidos à intervenção cirúrgica bariátrica aberta, sob anestesia com propofol e alfentanil acrescidos ou não de dexmedetomidina. Os pacientes foram alocados em dois grupos: Controle (propofol e alfentanil e Dexmedetomidina (propofol, alfentanil e dexmedetomidina. A manutenção da anestesia nos dois grupos constou de propofol = 0,075 a 0,1 mg.kg-1.min-1 e alfentanil = 0,75 a 1 µg.kg-1.min-1; no grupo Dexmedetomidina na dose inicial de 1 µg.kg-1 em 10 min e manutenção com 0,4 a 0,7 µg.kg-1.h-1. As variáveis estudadas foram idade, sexo, IMC, tempos cirúrgico e de despertar, freqüência cardíaca (FC, pressão arterial sistólica e diastólica (PAS, PAD, saturação periférica de hemoglobina (SpO2, consumo de propofol e alfentanil e efeitos colaterais. RESULTADOS: Houve redução significativa do consumo de propofol e alfentanil no grupo Dexmedetomidina. A FC apresentou variação significativa apenas no grupo Dexmedetomidina. A PAS e a PAD apresentaram redução estatística significativa nos dois grupos nos primeiros 20 min, estabilizando-se a seguir. Os pacientes dos dois grupos não apresentaram efeitos colaterais. CONCLUSÕES: Este estudo demonstrou a eficácia do uso da dexmedetomidina associada à anestesia venosa com propofol e alfentanil, promovendo redução do consumo dos anestésicos venosos, estabilidade cardiovascular e tempo de despertar similar à técnica sem adição de dexmedetomidina. N

  7. Prática alimentar e de atividade física em adolescentes obesos de escolas públicas e privadas

    Directory of Open Access Journals (Sweden)

    Lívia Freitas Campos

    2014-03-01

    Full Text Available Objetivo: Avaliar a prática alimentar e o nível de atividade física em adolescentes obesos de escolas públicas (EPu e privadas (EPr de Fortaleza-CE. Métodos: Estudo transversal realizado com 272 adolescentes de Epu e EPr, no período de abril de 2007 a maio de 2009. Aplicou-se um questionário contendo dados de identificação (idade, sexo, antropométricos (peso e altura, situação escolar, prática alimentar e nível de atividade física. Resultados: Dos avaliados, observou-se que 160 (58,8% eram do sexo feminino, com idade média de 16,5 anos (±1,31. Houve prevalência da obesidade moderada, com 85,5%, (n=171 na EPu e 76,4%, (n=55 na EPr. Não se constatou diferença entre o grau de obesidade e a rede escolar. Sobre a prática alimentar, 70,2% (n=190 consumiam menos de cinco refeições ao dia e 56,3% (n=153 não faziam o café da manhã, não tendo diferença entre as redes escolares. O consumo de frutas (10%; n=27 e vegetais (14,1%; n=38 foi baixo. Os estudantes das EPr consumiam mais refrigerantes (41,7%; n=30 do que os da EPu (28,5%; n=57; p=0,03. Constatou-se, que 47% (n=93 dos alunos da EPu e que 32,4% (n=27 da EPr não consumiam fast-food (p=0,02. Identificou-se que os adolescentes das EPu eram mais ativos do que os das EPr (77%; n=153 versus 54,2%; n=40; p=0,0002, mas essa diferença não mostrou associação com o grau de obesidade (p=0,88. Conclusão: Os adolescentes das escolas públicas e particulares apresentavam prática alimentar inadequada, havendo poucas diferenças entre eles. Os jovens das EPu apresentaram-se mais ativos que os das EPr, entretanto, este nível de atividade física não influenciou no grau de obesidade. doi:10.5020/18061230.2014.p92

  8. Problemas Psicológicos e Psicodinâmicos de crianças e adolescentes obesos: relato de pesquisa

    Directory of Open Access Journals (Sweden)

    Tarsila de Magalhães Andrade

    Full Text Available objetivo: Descrever e discutir os principais problemas psicológicos e psicodinâmicos de crianças e adolescentes obesos, considerando as variáveis individuais e as condutas psicológicas indicadas de acordo com a necessidade/ gravidade dos problemas apresentados. Método: Estudo transversal, retrospectivo, baseado no banco de dados das avaliações psicológicas de 491 casos selecionados de obesidade exógena de 1991 a 2007. O banco de dados foi organizado a partir de estudo preliminar para a caracterização dos principais problemas, variáveis individuais e condutas, e os dados analisados por distribuição de frequência, apresentados sob a forma de tabelas. Resultados: Resultados indicativos de 32,4% de casos de pais superprotetores ou de mães simbioticamente ligadas ao filho, 24,4% de casos de rejeição materna e consequente carência de afeto, 7,9% com pais alcoólicos ou drogadictos, 12,2% com pais portadores de graves problemas de saúde mental, que sofriam violências e maus tratos, 14,3% que passavam por angústias circunstanciais, mas com bons recursos internos e 8,8% de casos graves, que apresentavam imaturidade emocional. A psicodinâmica familiar perturbada levava as crianças a angústias, voracidade, sedentarismo, dificuldades escolares, isolamento ou agressividade. Queixas de discriminação social e baixa autoestima foram encontradas em grande parte, assim como queixas de incontrolável ansiedade, que levavam aos exageros alimentares. Conclusão: Dos 491 casos avaliados, somente 14,3% eram casos sem comprometimento emocional, tratando-se de angústias circunstanciais, ligadas ao momento existencial. Os demais casos, ou seja, 85,7%, mostravam raízes profundamente intrincadas na psicodinâmica familiar e requeriam cuidados, orientações e psicoterapia dirigidos não só ao paciente como também à sua família.

  9. Prática alimentar e de atividade física em adolescentes obesos de escolas públicas e privadas

    Directory of Open Access Journals (Sweden)

    Lívia Freitas Campos

    2014-03-01

    Full Text Available Objetivo: Avaliar a prática alimentar e o nível de atividade física em adolescentes obesos de escolas públicas (EPu e privadas (EPr de Fortaleza-CE. Métodos: Estudo transversal realizado com 272 adolescentes de Epu e EPr, no período de abril de 2007 a maio de 2009. Aplicou-se um questionário contendo dados de identificação (idade, sexo, antropométricos (peso e altura, situação escolar, prática alimentar e nível de atividade física. Resultados: Dos avaliados, observou-se que 160 (58,8% eram do sexo feminino, com idade média de 16,5 anos (±1,31. Houve prevalência da obesidade moderada, com 85,5%, (n=171 na EPu e 76,4%, (n=55 na EPr. Não se constatou diferença entre o grau de obesidade e a rede escolar. Sobre a prática alimentar, 70,2% (n=190 consumiam menos de cinco refeições ao dia e 56,3% (n=153 não faziam o café da manhã, não tendo diferença entre as redes escolares. O consumo de frutas (10%; n=27 e vegetais (14,1%; n=38 foi baixo. Os estudantes das EPr consumiam mais refrigerantes (41,7%; n=30 do que os da EPu (28,5%; n=57; p=0,03. Constatou-se, que 47% (n=93 dos alunos da EPu e que 32,4% (n=27 da EPr não consumiam fast-food (p=0,02. Identificou-se que os adolescentes das EPu eram mais ativos do que os das EPr (77%; n=153 versus 54,2%; n=40; p=0,0002, mas essa diferença não mostrou associação com o grau de obesidade (p=0,88. Conclusão: Os adolescentes das escolas públicas e particulares apresentavam prática alimentar inadequada, havendo poucas diferenças entre eles. Os jovens das EPu apresentaram-se mais ativos que os das EPr, entretanto, este nível de atividade física não influenciou no grau de obesidade.

  10. Mono-jet signatures of gluphilic scalar dark matter

    Directory of Open Access Journals (Sweden)

    Rohini M. Godbole

    2017-09-01

    Full Text Available A gluphilic scalar dark matter (GSDM model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum (“mono-jet” in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT treatment, and find (as expected that EFT does not accurately describe regions of parameter space where mass of the colored mediator particles are comparable to the experimental cuts on the missing energy. We determine bounds (for several choices of SU(3 representation of the mediator from the s=8 TeV data, and show the expected reach of the s=13 TeV LHC and a future 100 TeV pp collider to constrain or discover GSDM models.

  11. Mechanically flexible optically transparent porous mono-crystalline silicon substrate

    KAUST Repository

    Rojas, Jhonathan Prieto; Syed, Ahad A.; Hussain, Muhammad Mustafa

    2012-01-01

    For the first time, we present a simple process to fabricate a thin (≥5μm), mechanically flexible, optically transparent, porous mono-crystalline silicon substrate. Relying only on reactive ion etching steps, we are able to controllably peel off a thin layer of the original substrate. This scheme is cost favorable as it uses a low-cost silicon <100> wafer and furthermore it has the potential for recycling the remaining part of the wafer that otherwise would be lost and wasted during conventional back-grinding process. Due to its porosity, it shows see-through transparency and potential for flexible membrane applications, neural probing and such. Our process can offer flexible, transparent silicon from post high-thermal budget processed device wafer to retain the high performance electronics on flexible substrates. © 2012 IEEE.

  12. Behavior of the potential-induced degradation of photovoltaic modules fabricated using flat mono-crystalline silicon cells with different surface orientations

    Science.gov (United States)

    Yamaguchi, Seira; Masuda, Atsushi; Ohdaira, Keisuke

    2016-04-01

    This paper deals with the dependence of the potential-induced degradation (PID) of flat, p-type mono-crystalline silicon solar cell modules on the surface orientation of solar cells. The investigated modules were fabricated from p-type mono-crystalline silicon cells with a (100) or (111) surface orientation using a module laminator. PID tests were performed by applying a voltage of -1000 V to shorted module interconnector ribbons with respect to an Al plate placed on the cover glass of the modules at 85 °C. A decrease in the parallel resistance of the (100)-oriented cell modules is more significant than that of the (111)-oriented cell modules. Hence, the performance of the (100)-oriented-cell modules drastically deteriorates, compared with that of the (111)-oriented-cell modules. This implies that (111)-oriented cells offer a higher PID resistance.

  13. Synthesis, purification, and time-dependent disposition studies of 9- or 10-mono-iodostearic acid and 9- and 10-mono-iodostearyl carnitine

    International Nuclear Information System (INIS)

    Reed, K.W.

    1985-01-01

    The purpose of this investigation was to evaluate the potential use of radiolabeled 9- or 10-mono-iodostearyl carnitine as a perfusion and metabolic imaging agent for the heart. Radiochemical purity was achieved and determined by the use of silica gel and/or anion exchange resin chromatography. Radiochemical yields of 45-63 and 4% were obtained for the fatty acid and carnitine ester, respectively. Male albino mice were sacrificed at 2, 5, 7, 10, 15, 20, 30, and 50 minutes post-injection with either 125 I 9- or 10-mono-iodostearic acid or 9- or 10-mono-iodostearyl (-) carnitine. The lungs, liver heart, kidney, spleen, pancreas, small intestine, stomach, thyroid, blood, fat, and skeletal muscle tissue were excised and assayed for levels of radioactivity in a NaI crystal well counter. The very low target-to-nontarget ratios obtained with 125 I 9- or 10-mono-iodostearyl carnitine in mice strongly suggest that radioiodinated 9- or 10-mono-iodostearyl carnitine is not suitable for use as a myocardial imaging agent. However, radioiodinated 9- or 10-mono-iodostearic acid showed promise as a myocardial imaging agent and may warrant further investigation

  14. Behavioral ecology of American Pikas (Ochotona princeps) at Mono Craters, California: living on the edge

    Science.gov (United States)

    Andrew T. Smith; John D. Nagy; Connie Millar

    2016-01-01

    The behavioral ecology of the American pika (Ochotona princeps) was investigated at a relatively hot south-facing, low-elevation site in the Mono Craters, California, a habitat quite different from the upper montane regions more typically inhabited by this species and where most prior investigations have been conducted. Mono Craters pikas exhibited...

  15. Magnetic and gravity studies of Mono Lake, east-central, California

    Science.gov (United States)

    Athens, Noah D.; Ponce, David A.; Jayko, Angela S.; Miller, Matt; McEvoy, Bobby; Marcaida, Mae; Mangan, Margaret T.; Wilkinson, Stuart K.; McClain, James S.; Chuchel, Bruce A.; Denton, Kevin M.

    2014-01-01

    From August 26 to September 5, 2011, the U.S. Geological Survey (USGS) collected more than 600 line-kilometers of shipborne magnetic data on Mono Lake, 20 line-kilometers of ground magnetic data on Paoha Island, 50 gravity stations on Paoha and Negit Islands, and 28 rock samples on Paoha and Negit Islands, in east-central California. Magnetic and gravity investigations were undertaken in Mono Lake to study regional crustal structures and to aid in understanding the geologic framework, in particular regarding potential geothermal resources and volcanic hazards throughout Mono Basin. Furthermore, shipborne magnetic data illuminate local structures in the upper crust beneath Mono Lake where geologic exposure is absent. Magnetic and gravity methods, which sense contrasting physical properties of the subsurface, are ideal for studying Mono Lake. Exposed rock units surrounding Mono Lake consist mainly of Quaternary alluvium, lacustrine sediment, aeolian deposits, basalt, and Paleozoic granitic and metasedimentary rocks (Bailey, 1989). At Black Point, on the northwest shore of Mono Lake, there is a mafic cinder cone that was produced by a subaqueous eruption around 13.3 ka. Within Mono Lake there are several small dacite cinder cones and flows, forming Negit Island and part of Paoha Island, which also host deposits of Quaternary lacustrine sediments. The typical density and magnetic properties of young volcanic rocks contrast with those of the lacustrine sediment, enabling us to map their subsurface extent.

  16. [Cambios en la salud sexual de los pacientes obesos tras cirugía bariátrica].

    Science.gov (United States)

    Pomares-Callejón, María A; Ferrer-Márquez, Manuel; Solvas-Salmerón, María J

    2018-01-01

    Los objetivos del estudio fueron: 1) evaluar la salud sexual en pacientes con obesidad grave/mórbida candidatos a cirugía bariátrica; y 2) valorar la evolución de la salud sexual tras 12 meses de la cirugía. Estudio descriptivo, prospectivo desde febrero de 2011 hasta junio de 2014. Se valoró la actividad sexual en los hombres a través del cuestionario EVAS-H y la función sexual en la mujer a través de la escala FSM (44 pacientes). Durante el estudio basal en los hombres, un 21% de la muestra presentó disfunción sexual en diferentes dimensiones, mientras que un 43% presentó problemas de eyaculación precoz. Tras 12 meses de la intervención, se observó un incremento de la actividad sexual global (p = 0.026). En torno al 70-89% de las mujeres, previamente a la cirugía, no presentaban trastorno. En la evolución no se observaron cambios medios relevantes (p > 0.05). Los pacientes con obesidad grave/mórbida candidatos a cirugía bariátrica presentan alteraciones considerables en diversas dimensiones de la salud sexual. Después de 12 meses de seguimiento, la salud sexual parece mejorar en los hombres. The aims of the study were: 1) to assess sexual health patients severe/morbid obesity patients candidates for bariatric surgery; and 2) to assess sexual health evolution after 12 months of surgery. Descriptive, prospective study from February 2011 to June 2014. Sexual activity in men was valued through EVAS-H questionnaire and through FSM scale on women (44 patients). During the basal study in men, a 21% of the sample showed sexual disfunction in different dimensions, while a 43% showed problems with premature ejaculation. 12 months after surgery, global sexual activity was improved significantly (p = 0,026). Approximately 70-89% of women presented no disturbance before surgery. No average relevant changes were observed within the evolution (p > 0.05). Morbid/severe obesity patients candidates to bariatric surgery, show considerable alterations on diverse

  17. ALS Association

    Science.gov (United States)

    ... toward a world without ALS! Walk to Defeat ALS® Walk to Defeat ALS® draws people of all ... We need your help. I Will Advocate National ALS Registry The National ALS Registry is a congressionally ...

  18. Prevalência dos riscos cardiovasculares em escolares e adolescentes obesos acompanhados no ambulatório de endocrinologia pediátrica do Conjunto Hospitalar de Sorocaba (CHS

    Directory of Open Access Journals (Sweden)

    Karlla Karollynna de Fátima Gaiotto

    2015-10-01

    Full Text Available Crianças e adolescentes obesos têm alto risco de desenvolver doençascardiovasculares na idade adulta. Assim, a detecção de fatores de risco e educaçãodos pacientes na infância é de extrema importância para o prognóstico, já que nesseperíodo a mudança dos hábitos de vida demonstra grande redução na incidência egravidade de doenças cardíacas. Desta forma, o objetivo do projeto foi avaliarrepercussões metabólicas associadas à obesidade nos pacientes atendidos noambulatório de endocrinologia pediátrica do CHS e seu impacto nos riscoscardiovasculares. Para isto foi realizada a análise do perfil bioquímico,antropométrico e níveis pressóricos de escolares e adolescentes obesos com idadeentre 07 e 18 anos no período de agosto de 2014 a maio de 2015 e calculada aprevalência para cada variável analisada. Dos 49 pacientes, 57,1% nasceram compeso adequado, 46,9% praticam atividade física insuficiente, 42,9% apresentamobesidade na família, 59,1% apresentam parentes obesos com algumacomorbidade, 81,3% se encaixam no percentil acima de 99 para o IMC, 90,55%apresentam circunferência de cintura acima de 71 cm, 44,1% foram consideradoshipertensos, 20,4% apresentaram alterações no perfil glicêmico, 34,7% possuemcolesterol total aumentado, 59,2% estão com HDL inferior ao desejável, 40,9%estão com níveis alterados de LDL, 49% apresentaram valores de VLDL elevado e30,6% apresentaram triglicérides aumentados. A análise dos dados deste estudopermite inferir que o IMC, pressão arterial, circunferência abdominal, colesterol total,HDL colesterol e triglicérides são aqueles cujos valores são mais expressivos, demonstrando as consequências diretas da obesidade no aumento do risco deeventos cardiovasculares futuros.

  19. Familial ALS

    Science.gov (United States)

    Boylan, Kevin

    2015-01-01

    Synopsis Genes linked to ALS susceptibility are being identified at an increasing rate owing to advances in molecular genetic technology. Genetic mechanisms in ALS pathogenesis appear to exert major effects in ~10% of patients, but genetic factors at some level may be important components of disease risk in most ALS patients. Identification of gene variants associated with ALS has informed concepts of the pathogenesis of ALS, aided the identification of therapeutic targets, facilitated research to develop new ALS biomarkers, and supported the establishment of clinical diagnostic tests for ALS-linked genes. Translation of this knowledge to ALS therapy development is ongoing. PMID:26515623

  20. Uso de preditores clínicos simples no diagnóstico pré-operatório de dificuldade de intubação endotraqueal em pacientes portadores de obesidade Uso de predictores clínicos sencillos en el diagnóstico preoperatorio de dificultad de intubación endotraqueal en pacientes obesos Use of simple clinical predictors on preoperative diagnosis of difficult endotracheal intubation in obese patients

    Directory of Open Access Journals (Sweden)

    Edno Magalhães

    2013-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar da semelhante incidência de dificuldade à laringoscopia em obesos e não obesos há mais relatos de dificuldade de intubação endotraqueal em portadores de obesidade. Alternativas de diagnóstico e previsão de dificuldade de intubação no pré-operatório podem ajudar diminuir complicações anestésicas em indivíduos obesos. O objetivo do estudo foi identificar preditores para diagnóstico de via aérea difícil em pacientes obesos, pela correlação com métodos clínicos de avaliação pré-anestésica e polissonografia. Comparou-se também a incidência de dificuldade à ventilação sob máscara facial e à laringoscopia entre obesos e não obesos, verificando os preditores mais prevalentes. MÉTODOS: Estudo observacional, prospectivo, comparativo, com 88 pacientes adultos, submetidos à anestesia geral. No período pré-operatório, avaliou-se questionário sobre preditores clínicos de síndrome da apneia obstrutiva do sono (SAOS e parâmetros anatômicos. Durante a anestesia, pesquisou-se dificuldade à ventilação sob máscara facial e laringoscopia. Para análise, estatística descritiva e teste de correlação. RESULTADOS: Os pacientes foram alocados em dois grupos, 43 obesos e 45 não obesos. Estado físico, prevalência de roncos, hipertensão e diabetes mellitus, circunferência cervical e índice de Mallampati foram maiores nos obesos. Pacientes obesos apresentaram maior incidência de dificuldade de ventilação sob máscara e laringoscopia. Nenhuma variável clínica ou anatômica apresentou correlação com dificuldade de ventilação sob máscara nos grupos. Nos obesos, o diagnóstico de SAOS mostrou forte correlação com dificuldade à laringoscopia. CONCLUSÕES: Os diagnósticos clínico e polissonográfico de SAOS se mostraram úteis no diagnóstico pré-operatório de dificuldade à laringoscopia. Pacientes obesos estão mais propensos à dificuldade de ventilação sob máscara e

  1. Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice

    DEFF Research Database (Denmark)

    Hansen, Jitka Stilund; Larsen, Søren Thor; Poulsen, Lars K.

    2007-01-01

    Phthalates, including di(2-ethylhexyl) phthalate (DEHP), are widely used and have been linked with the development of wheezing and asthma. The main metabolite of DEHP, mono-2-ethylhexyl phthalate (MEHP), was investigated for adjuvant effects in a mouse inhalation model. BALB/cJ mice were exposed...... to aerosols of 0.03 or 0.4 mg/m(3) MEHP 5 days/week for 2 weeks and thereafter weekly for 12 weeks together with a low dose of ovalbumin (OVA) as a model allergen. Mice exposed to OVA alone or OVA+Al(OH)(3) served as negative and positive controls, respectively. Finally, all groups were exposed to a nebulized...... as of eosinophils in BAL fluid were observed. OVA-specific IgG1 production in both MEHP groups was significantly increased. OVA-specific IgE and IgG2a were not increased significantly. A dose-dependent increase in inflammatory cells was observed in BAL fluid, leading to significantly higher lymphocyte...

  2. 21 CFR 582.4505 - Mono- and diglycerides of edible fats or oils, or edible fat-forming acids.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Mono- and diglycerides of edible fats or oils, or... GENERALLY RECOGNIZED AS SAFE Emulsifying Agents § 582.4505 Mono- and diglycerides of edible fats or oils, or edible fat-forming acids. (a) Product. Mono- and diglycerides of edible fats or oils, or edible fat...

  3. Ferrous sulphate mono and heptahydrate reduction of hexavalent chromium in cement: effectiveness and storability

    Directory of Open Access Journals (Sweden)

    Valverde, J. L.

    2005-09-01

    Full Text Available In Community legislation, substances containing hexavalent chromium are classified as carcinogenic, mutagenic and sensitizing. In cement, hexavalent chromium intensifies sensitization and may set off severe allergic reactions in workers in routine contact with the product, whether in the factory or on construction sites. The allergic or contact dermatitis causes is a very painful disease that may lead to permanent worker disability. According to Directive 2003/53/EC of the European Parliament and the Council, Governments of all member countries will be required to prohibit the marketing and use, as of 17 January 2005, of any cement or cement preparation containing more than 2 ppm of chromium (VI. Hexavalent chromium can be reduced with ferrous sulphate to trivalent chromium, which is water-insoluble and therefore innocuous to the skin. The present paper reports the effects of adding ferrous sulphate mono- or heptahydrate to a commercial cement and the storage time of the mix on the concentration of hexavalent chromium. The salts studied were found to effectively reduce hexavalent chromium in cement for at least three months.

    Las sustancias que contienen cromo hexavalente están clasificadas en la legislación comunitaria como sustancias carcinogénicas, mutagénicas y sensibilizantes. El cromo hexavalente del cemento potencia la sensibilización y provoca graves reacciones alérgicas que sufren bastante a menudo los trabajadores que lo manipulan habitualmente, ya sea en fábrica o en el sector de la construcción. La dermatitis alérgica o de contacto que produce es muy dolorosa y puede dejar a los trabajadores en estado de discapacidad. La Directiva 2003/53/CE del Parlamento Europeo y del Consejo, exige a los Gobiernos de los países miembros, que a partir del 17 de enero de 2005, prohiban el uso y la comercialización de todos aquellos cementos y preparados que contengan cemento, cuyo contenido en cromo (VI soluble, una vez hidratados

  4. Interrelación dialéctica entre lo biológico y social en relación con factores de riesgo cardiovasculares en pacientes diabéticos obeso Tipo 2

    OpenAIRE

    Socarrás Súarez, María Matilde; Amaro Cano, María del Carmen; Blanco Anesto, Jorge

    2002-01-01

    Se realizó una revisión bibliográfica sobre el fenómeno de la interrelación dialéctica entre lo biológico y lo social en el caso de factores de riesgo cardiovasculares, en pacientes diabéticos tipo 2 obesos. Ha sido considerado el envejecimiento, expresado en el incremento cada vez mayor de personas con edad de más de 60 años, el cual está determinando sobre la prevalencia de la enfermedad. Los factores sociales como hábitos de vida, hábitos alimentarios y estilos de vida, determinan, en últi...

  5. Professional iPhone Programming with MonoTouch and .NET/C#

    CERN Document Server

    McClure, Wallace B; Dunn, Craig

    2010-01-01

    What .NET C# developers need to enter the hot field of iPhone apps. iPhone applications offer a hot opportunity for developers. Until the open source MonoTouch project, this field was limited to those familiar with Apple's programming languages. Now .NET and C# developers can join the party. This Wrox guide is the first book to cover MonoTouch, preparing developers to take advantage of this lucrative opportunity.: MonoTouch opens the field of iPhone app development to .NET and C# developers for the first time; the Wrox reputation among .NET developers assures them that this guide covers everyt

  6. THE RECOGNITION OF SPOKEN MONO-MORPHEMIC COMPOUNDS IN CHINESE

    Directory of Open Access Journals (Sweden)

    Yu-da Lai

    2012-12-01

    Full Text Available This paper explores the auditory lexical access of mono-morphemic compounds in Chinese as a way of understanding the role of orthography in the recognition of spoken words. In traditional Chinese linguistics, a compound is a word written with two or more characters whether or not they are morphemic. A monomorphemic compound may either be a binding word, written with characters that only appear in this one word, or a non-binding word, written with characters that are chosen for their pronunciation but that also appear in other words. Our goal was to determine if this purely orthographic difference affects auditory lexical access by conducting a series of four experiments with materials matched by whole-word frequency, syllable frequency, cross-syllable predictability, cohort size, and acoustic duration, but differing in binding. An auditory lexical decision task (LDT found an orthographic effect: binding words were recognized more quickly than non-binding words. However, this effect disappeared in an auditory repetition and in a visual LDT with the same materials, implying that the orthographic effect during auditory lexical access was localized to the decision component and involved the influence of cross-character predictability without the activation of orthographic representations. This claim was further confirmed by overall faster recognition of spoken binding words in a cross-modal LDT with different types of visual interference. The theoretical and practical consequences of these findings are discussed.

  7. Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

    Science.gov (United States)

    Korstanje, Ron; Deutsch, Konstantin; Bolanos-Palmieri, Patricia; Hanke, Nils; Schroder, Patricia; Staggs, Lynne; Bräsen, Jan H; Roberts, Ian S D; Sheehan, Susan; Savage, Holly; Haller, Hermann; Schiffer, Mario

    2016-11-01

    Changes in metabolite levels of the kynurenine pathway have been observed in patients with CKD, suggesting involvement of this pathway in disease pathogenesis. Our recent genetic analysis in the mouse identified the kynurenine 3-mono-oxygenase (KMO) gene (Kmo) as a candidate gene associated with albuminuria. This study investigated this association in more detail. We compared KMO abundance in the glomeruli of mice and humans under normal and diabetic conditions, observing a decrease in glomerular KMO expression with diabetes. Knockdown of kmo expression in zebrafish and genetic deletion of Kmo in mice each led to a proteinuria phenotype. We observed pronounced podocyte foot process effacement on long stretches of the filtration barrier in the zebrafish knockdown model and mild podocyte foot process effacement in the mouse model, whereas all other structures within the kidney remained unremarkable. These data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes. Copyright © 2016 by the American Society of Nephrology.

  8. Fringing in MonoCam Y4 filter images

    International Nuclear Information System (INIS)

    Brooks, J.; Nomerotski, A.; Fisher-Levine, M.

    2017-01-01

    We study the fringing patterns observed in MonoCam, a camera with a single Large Synoptic Survey Telescope (LSST) CCD sensor. Images were taken at the U.S. Naval Observatory in Flagstaff, Arizona (NOFS) employing its 1.3 m telescope and an LSST y 4 filter. Fringing occurs due to the reflection of infrared light (700 nm or larger) from the bottom surface of the CCD which constructively or destructively interferes with the incident light to produce a net ''fringe'' pattern which is superimposed on all images taken. Emission lines from the atmosphere, dominated by hydroxyl (OH) spectra, can change in their relative intensities as the night goes on, producing different fringe patterns in the images taken. We found through several methods that the general shape of the fringe patterns remained constant, though with slight changes in the amplitude and phase of the fringes. We also found that a superposition of fringes from two monochromatic lines taken in the lab offered a reasonable description of the sky data.

  9. Electron transfer kinetics on mono- and multilayer graphene.

    Science.gov (United States)

    Velický, Matěj; Bradley, Dan F; Cooper, Adam J; Hill, Ernie W; Kinloch, Ian A; Mishchenko, Artem; Novoselov, Konstantin S; Patten, Hollie V; Toth, Peter S; Valota, Anna T; Worrall, Stephen D; Dryfe, Robert A W

    2014-10-28

    Understanding of the electrochemical properties of graphene, especially the electron transfer kinetics of a redox reaction between the graphene surface and a molecule, in comparison to graphite or other carbon-based materials, is essential for its potential in energy conversion and storage to be realized. Here we use voltammetric determination of the electron transfer rate for three redox mediators, ferricyanide, hexaammineruthenium, and hexachloroiridate (Fe(CN)(6)(3-), Ru(NH3)(6)(3+), and IrCl(6)(2-), respectively), to measure the reactivity of graphene samples prepared by mechanical exfoliation of natural graphite. Electron transfer rates are measured for varied number of graphene layers (1 to ca. 1000 layers) using microscopic droplets. The basal planes of mono- and multilayer graphene, supported on an insulating Si/SiO(2) substrate, exhibit significant electron transfer activity and changes in kinetics are observed for all three mediators. No significant trend in kinetics with flake thickness is discernible for each mediator; however, a large variation in kinetics is observed across the basal plane of the same flakes, indicating that local surface conditions affect the electrochemical performance. This is confirmed by in situ graphite exfoliation, which reveals significant deterioration of initially, near-reversible kinetics for Ru(NH3)(6)(3+) when comparing the atmosphere-aged and freshly exfoliated graphite surfaces.

  10. Mono-energy coronary angiography with a compact light source

    Science.gov (United States)

    Eggl, Elena; Mechlem, Korbinian; Braig, Eva; Kulpe, Stephanie; Dierolf, Martin; Günther, Benedikt; Achterhold, Klaus; Herzen, Julia; Gleich, Bernhard; Rummeny, Ernst; Noël, Peter B.; Pfeiffer, Franz; Muenzel, Daniela

    2017-03-01

    While conventional x-ray tube sources reliably provide high-power x-ray beams for everyday clinical practice, the broad spectra that are inherent to these sources compromise the diagnostic image quality. For a monochromatic x-ray source on the other hand, the x-ray energy can be adjusted to optimal conditions with respect to contrast and dose. However, large-scale synchrotron sources impose high spatial and financial demands, making them unsuitable for clinical practice. During the last decades, research has brought up compact synchrotron sources based on inverse Compton scattering, which deliver a highly brilliant, quasi-monochromatic, tunable x-ray beam, yet fitting into a standard laboratory. One application that could benefit from the invention of these sources in clinical practice is coronary angiography. Being an important and frequently applied diagnostic tool, a high number of complications in angiography, such as renal failure, allergic reaction, or hyperthyroidism, are caused by the large amount of iodine-based contrast agent that is required for achieving sufficient image contrast. Here we demonstrate monochromatic angiography of a porcine heart acquired at the MuCLS, the first compact synchrotron source. By means of a simulation, the CNR in a coronary angiography image achieved with the quasi-mono-energetic MuCLS spectrum is analyzed and compared to a conventional x-ray-tube spectrum. The results imply that the improved CNR achieved with a quasi-monochromatic spectrum can allow for a significant reduction of iodine contrast material.

  11. Conventional laparoscopic adrenalectomy versus laparoscopic adrenalectomy through mono port.

    Science.gov (United States)

    Kwak, Ha Na; Kim, Jun Ho; Yun, Ji-Sup; Son, Byung Ho; Chung, Woong Youn; Park, Yong Lai; Park, Chan Heun

    2011-12-01

    A standard procedure for single-port laparoscopic adrenal surgery has not been established. We retrospectively investigated intraoperative and postoperative outcomes after laparoscopic adrenalectomy through mono port (LAMP) and conventional laparoscopic adrenalectomy to assess the feasibility of LAMP. Between March 2008 and December 2009, 22 patients underwent adrenalectomy at the Department of Surgery, Kangbuk Samsung Hospital. Twelve patients underwent conventional laparoscopic adrenalectomy and 10 patients underwent LAMP. The same surgeon performed all the surgeries. The 2 procedures were compared in terms of tumor size, operating time, time to resumption of a soft diet, length of hospital day, and postoperative complications. The 2 groups were similar in terms of tumor size (30.08 vs. 32.50 mm, P=0.796), mean operating time (112.9 vs. 127 min, P=0.316), time to resumption of a soft diet (1.25 vs. 1.30 d, P=0.805), and length of hospital day (4.08 vs. 4.50 d, P=0.447). Despite 1 patient in the LAMP group experiencing ipsilateral pleural effusion as a postoperative complication, this parameter was similar for the 2 groups (P=0.195). Perioperative mortality, blood transfusion, and conversion to open surgery did not occur. Perioperative outcomes for LAMP were similar to those for conventional laparoscopic adrenalectomy. LAMP appears to be a feasible option for adrenalectomy.

  12. Antioxidant and cytotoxic activity of mono- and bissalicylic acid derivatives

    Directory of Open Access Journals (Sweden)

    Đurendić Evgenija A.

    2014-01-01

    Full Text Available A simple synthesis of mono- and bis-salicylic acid derivatives 1-10 by the transesterification of methyl salicylate (methyl 2-hydroxybenzoate with 3-oxapentane-1,5-diol, 3,6- dioxaoctane-1,8-diol, 3,6,9-trioxaundecane-1,11-diol, propane-1,2-diol or 1-aminopropan- 2-ol in alkaline conditions is reported. All compounds were tested in vitro on three malignant cell lines (MCF-7, MDA-MB-231, PC-3 and one non-tumor cell line (MRC- 5. Strong cytotoxicity against prostate PC-3 cancer cells expressed compounds 3, 4, 6, 9 and 10, all with the IC50 less than 10 μmol/L, which were 11-27 times higher than the cytotoxicity of antitumor drug doxorubicin. All tested compounds were not toxic against the non-tumor MRC-5 cell line. Antioxidant activity of the synthesized derivatives was also evaluated. Compounds 2, 5 and 8 were better OH radical scavengers than commercial antioxidants BHT and BHA. The synthesized compounds showed satisfactory scavenger activity, which was studied by QSAR modeling. A good correlation between the experimental variables IC50 DPPH and IC50 OH and MTI (molecular topological indices molecular descriptors and CAA (accessible Connolly solvent surface area for the new compounds 1, 3, and 5 was observed.

  13. White tea (Camellia sinensis extract reduces oxidative stress and triacylglycerols in obese mice Extrato de chá branco reduz extresse oxidativo e triacilglicerois em camundongos obesos

    Directory of Open Access Journals (Sweden)

    Lílian Gonçalves Teixeira

    2012-12-01

    com 0,5% de extrato de chá branco durante 8 semanas. Foram estudadoso tecido adiposo bem como o perfil lipídico e o estresse oxidativo. A suplementação com chá branco não foi capaz de reduzir a ingestão alimentar, peso corporal ou adiposidade visceral. De forma similar, não foram encontradas diferenças no perfil de lipoproteínas ricas em colesterol. Uma redução de triacilgliceróis sanguíneos, associada ao aumento de lipídios cecais, foi observada no grupo suplementado com chá branco. A suplementação também reduziu o estresse oxidativo no fígado e tecido adiposo. Em conclusão, suplementação com extrato de chá branco (0,5% não interfere no peso corporal ou adiposidade em camundongos obesos. Seus benefícios são restritos redução do estresse oxidativo associada obesidade e melhora da hipertrigliceridemia.

  14. Retrofitting of beaters with mono-drive at a beater-wheel mill; Nachruestung von Vorschlaegern mit Mono-Antrieb an einer Schlagradmuehle

    Energy Technology Data Exchange (ETDEWEB)

    Krecher, Johannes J.; Hildebrandt, Rainer [Lignite-Mono-Drive Engineering GmbH, Essen (Germany); Geradts, Paul [RWE Power AG, Grevenbroich (Germany)

    2008-07-01

    Due to a future energy crisis, the use of the domestic brown coal continuously must be strengthened. At the beginning of 2007, the power station Frimmersdorf of RWE Power AG (Essen, Federal Republic of Germany) commissioned Lignite-Mono-Drive Engineering GmbH (Essen, Federal Republic of Germany) with the retrofitting of a N90.60 beater-wheel mill to a mono-drive-system. Thus, the production losses of 20 GWh/a of the 150 MW brown coal block M should be avoided, and the performance of this brown coal block should be increased by nearly 3 MW. Apart from the milling process and drying process, the authors of the contribution under consideration describe the application and operation results of these mono-drive-mills.

  15. Calix[6]arene mono-diazonium salt synthesis and covalent immobilization onto glassy carbon electrodes

    International Nuclear Information System (INIS)

    Cannizzo, Caroline; Jasmin, Jean-Philippe; Vautrin-Ul, Christine; Chausse, Annie; Wagner, Mathieu; Doizi, Denis; Lamouroux, Christine

    2014-01-01

    This Letter describes the fast synthesis of a mono-aminated calix[6]arene. The immobilization of this macrocycle onto glassy carbon electrodes via diazonium salt chemistry and the electrochemical characterization of the grafted organic layer are also reported. (authors)

  16. Developing C# Apps for iPhone and iPad using MonoTouch

    CERN Document Server

    Costanich, Bryan

    2011-01-01

    Developing C# Applications for iPhone and iPad using MonoTouch shows you how to use your existing C# skills to write apps for the iPhone and iPad. Fortunately, there's MonoTouch, Novell's .NET library that allows C# developers to write C# code that executes in iOS. Furthermore, MonoTouch allows you to address all the unique functions of the iPhone, iPod Touch, and iPad. And the big plus: You needn't learn any Objective-C to master MonoTouch!. Former Microsoft engineer and published app-store developer Bryan Costanich shows you how to use the tools you already know to create native apps in iOS

  17. Geothermal systems of the Mono Basin-Long Valley region, eastern California and western Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, C.T.; Flynn, T.; Chapman, R.H.; Trexler, D.T.; Chase, G.R.; Bacon, C.F.; Ghusn, G. Jr.

    1985-01-01

    The region that includes Mono Basin, Long Valley, the Bridgeport-Bodie Hills area, and Aurora, in eastern California and western Nevada was studied to determine the possible causes and interactions of the geothermal anomalies in the Mono Basin-Long Valley region as a whole. A special goal of the study was to locate possible shallow bodies of magma and to determine their influence on the hydrothermal systems in the region. (ACR)

  18. Discovery and industrial applications of lytic polysaccharide mono-oxygenases.

    Science.gov (United States)

    Johansen, Katja S

    2016-02-01

    The recent discovery of copper-dependent lytic polysaccharide mono-oxygenases (LPMOs) has opened up a vast area of research covering several fields of application. The biotech company Novozymes A/S holds patents on the use of these enzymes for the conversion of steam-pre-treated plant residues such as straw to free sugars. These patents predate the correct classification of LPMOs and the striking synergistic effect of fungal LPMOs when combined with canonical cellulases was discovered when fractions of fungal secretomes were evaluated in industrially relevant enzyme performance assays. Today, LPMOs are a central component in the Cellic CTec enzyme products which are used in several large-scale plants for the industrial production of lignocellulosic ethanol. LPMOs are characterized by an N-terminal histidine residue which, together with an internal histidine and a tyrosine residue, co-ordinates a single copper atom in a so-called histidine brace. The mechanism by which oxygen binds to the reduced copper atom has been reported and the general mechanism of copper-oxygen-mediated activation of carbon is being investigated in the light of these discoveries. LPMOs are widespread in both the fungal and the bacterial kingdoms, although the range of action of these enzymes remains to be elucidated. However, based on the high abundance of LPMOs expressed by microbes involved in the decomposition of organic matter, the importance of LPMOs in the natural carbon-cycle is predicted to be significant. In addition, it has been suggested that LPMOs play a role in the pathology of infectious diseases such as cholera and to thus be relevant in the field of medicine. © 2016 Authors; published by Portland Press Limited.

  19. Coaxial Mono-Energetic Gamma Generator for Active Interrogation

    International Nuclear Information System (INIS)

    Ludewigt, Bernhard A.; Antolak, A.J.; Henestroza, E.; Leitner, M.; Leung, K.-N.; Waldron, W.; Wilde, S.; Kwan, J.W.

    2008-01-01

    Compact mono-energetic photon sources are sought for active interrogation systems to detect shielded special nuclear materials in, for example, cargo containers, trucks and other vehicles. A prototype gamma interrogation source has been designed and built that utilizes the 11B(p,gamma)12C reaction to produce 12 MeV gamma-rays which are near the peak of the photofission cross section. In particular, the 11B(p,gamma)12C resonance at 163 kV allows the production of gammas at low proton acceleration voltages, thus keeping the design of a gamma generator comparatively small and simple. A coaxial design has been adopted with a toroidal-shaped plasma chamber surrounding a cylindrical gamma production target. The plasma discharge is driven by a 2 MHz rf-power supply (capable up to 50 kW) using a circular rf-antenna. Permanent magnets embedded in the walls of the plasma chamber generate a multi-cusp field that confines the plasma and allows higher plasma densities and lower gas pressures. About 100 proton beamlets are extracted through a slotted plasma electrode towards the target at the center of the device that is at a negative 180 kV. The target consists of LaB6 tiles that are brazed to a water-cooled cylindrical structure. The generator is designed to operate at 500 Hz with 20 mu s long pulses, and a 1percent duty factor by pulsing the ion source rf-power. A first-generation coaxial gamma source has been built for low duty factor experiments and testing.

  20. Prevalência de artralgia em indivíduos obesos no pré e pós-operatório tardio de cirurgia bariátrica = Prevalence of arthralgia in obese individuals in the pre and postoperative of bariatric surgery

    OpenAIRE

    Soccol, Franciella Baggio

    2009-01-01

    Objetivos: analisar a prevalência de artralgia no pré e no pós-operatório tardio de cirurgia bariátrica, comparar o índice de massa corporal (IMC) dos indivíduos obesos nos períodos pré e pós-operatório, verificar a associação entre teste de caminhada de seis minutos e artralgia e avaliar a correlação entre teste de caminhada de seis minutos e IMC. Métodos: estudo de coorte retrospectivo, composto por 43 indivíduos obesos que realizaram avaliação no período pré e pós-operatório tardio de ciru...

  1. Prevalência de artralgia em indivíduos obesos no pré e pós-operatório tardio de cirurgia bariátrica = Prevalence of arthralgia in obese individuals in the pre and postoperative of bariatric surgery

    OpenAIRE

    Soccol, Franciella Baggio

    2009-01-01

    Objetivos: analisar a prevalência de artralgia no pré e no pós-operatório tardio de cirurgia bariátrica, comparar o índice de massa corporal (IMC) dos indivíduos obesos nos períodos pré e pós-operatório, verificar a associação entre teste de caminhada de seis minutos e artralgia e avaliar a correlação entre teste de caminhada de seis minutos e IMC Métodos: estudo de coorte retrospectivo, composto por 43 indivíduos obesos que realizaram avaliação no período pré e pós-operatório tardio de ci...

  2. Efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I Effects of greater-than-5% weight reduction on hemodynamic, metabolic and neuroendocrine profiles of grade I obese subjects

    OpenAIRE

    Kelly Biancardini Gomes Barbato; Rita de Cássia Vieira Martins; Maria de Lourdes Guimarães Rodrigues; José Ueleres Braga; Emílio Antonio Francischetti; Virginia Genelhu

    2006-01-01

    OBJETIVO: Avaliar os efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I. MÉTODOS: Estudo observacional com 47 obesos grau I, média de idade de 33 anos, submetidos a orientação mensal quanto a dieta, exercício físico e comportamento alimentar, durante quatro meses. A pressão arterial, pelo método auscultatório, e a freqüência cardíaca, pelo método palpatório, foram avaliadas mensalmente, enquanto as seguintes variáveis (e respectivos ...

  3. Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes

    International Nuclear Information System (INIS)

    Wang Bei; Suzuki, Hiroyuki; Kato, Mitsuyasu

    2008-01-01

    TGF-β activates receptor-regulated Smad (R-Smad) through phosphorylation by type I receptors. Activated R-Smad binds to Smad4 and the complex translocates into the nucleus and stimulates the transcription of target genes through association with co-activators including p300. It is not clear, however, how activated Smad complexes are removed from target genes. In this study, we show that TGF-β enhances the mono-ubiquitination of Smad4. Smad4 mono-ubiquitination was promoted by p300 and suppressed by the c-Ski co-repressor. Smad4 mono-ubiquitination disrupted the interaction with Smad2 in the presence of constitutively active TGF-β type I receptor. Furthermore, mono-ubiquitinated Smad4 was not found in DNA-binding Smad complexes. A Smad4-Ubiquitin fusion protein, which mimics mono-ubiquitinated Smad4, enhanced localization to the cytoplasm. These results suggest that mono-ubiquitination of Smad4 occurs in the transcriptional activator complex and facilitates the turnover of Smad complexes at target genes

  4. Generalized dynamic model and control of ambiguous mono axial vehicle robot

    Directory of Open Access Journals (Sweden)

    Frantisek Duchon

    2016-09-01

    Full Text Available This article deals with the novel concept of ambiguous mono axial vehicle robot. Such robot is a combination of Segway and dicycle, which utilizes the advantages of each chassis. The advantage of dicycle is lower energy consumption during the movement and the higher safety of carried payload. The movable platform inside the ambiguous mono axial vehicle allows using the various sensors or devices. This will change the ambiguous mono axial vehicle to the Segway type robot. Both these modes are necessary to control in the stable mode to ensure the safety of the ambiguous mono axial vehicle’s movement. The main contents of the article contain description of generalized dynamic model of ambiguous mono axial vehicle and related control of ambiguous mono axial vehicle. The proposal is unique in that the same controller is used for both modes. Several simulations verify proposed control schemes and identified parameters. Moreover, the dicycle type of platform has never been used in robotics and that is another novelty.

  5. Vitamina C restaura pressão arterial e a resposta vasodilatadora no antebraço em crianças obesas Vitamina C restaura presión arterial y respuesta vasodilatadora en el antebrazo en niños obesos Vitamin C restores blood pressure and vasodilator response during mental stress in obese children

    Directory of Open Access Journals (Sweden)

    Pricilla Regina Oliveira Fernandes Fernandes

    2011-06-01

    ónico de la suplementación de vitamina C (VitC sobre la presión arterial y en la respuesta vasodilatadora al estrés mental. MÉTODOS: En este estudio prospectivo, randomizado y doble ciego fueron evaluados niños obesos, de ambos géneros, con edades entre 8 y 12 años divididos en 2 grupos: 1 grupo de niños suplementados con 500 mg de vitamina C (n = 11 y, 2 substancia placebo (n = 10 durante 45 días. Ocho niños eutróficos, pareados por edad también fueron incluidos en el estudio. Fueron evaluados la presión arterial media (PAM, la frecuencia cardíaca (ECG y el flujo sanguíneo en el antebrazo por plestimografía de oclusión venosa. La conductancia vascular en el antebrazo (CVA fue obtenida por medio de la relación entre el flujo sanguíneo en el antebrazo y la PAM (X100. RESULTADOS: Antes de la intervención, los niños obesos presentaron PAM mayor y CVA menor cuando fueron comparados con el Grupo C. Post intervención, el Grupo VitC presentó reducción de la PAM en reposo (81 ± 2 vs 75 ± 1 mmHg, p = 0,01, mientras en el Grupo Placebo no hubo alteración de la PAM (p = 0,58. Adicionalmente, VitC promovió un aumento de la CVA en reposo (3,40 ± 0,5 vs 5,09 ± 0,6 un, p = 0,04 y durante el estrés mental (3,92 ± 0,5 vs 6,68 ± 0,9 un, p = 0,03. Además de eso, post suplementación con VitC, los niveles de la CVA fueron estadísticamente semejantes a los del Grupo C en reposo (5,09 ± 0,6 vs 5,82 ± 0,4 un, p > 0,05 y durante el estrés mental (6,68 ± 0,9 vs 7,35 ± 0,5 un, p > 0,05. CONCLUSIÓN: Suplementación con VitC redujo la presión arterial y restableció la respuesta vasodilatadora periférica en niños obesos.BACKGROUND: Peripheral vasodilation response plays an important role in the pathophysiology of obesity and heart disease. OBJECTIVE: To evaluate the chronic effect of vitamin C (VitC supplementation on blood pressure and on vasodilation response to mental stress. METHODS: In a double-blind, randomized and prospective study we evaluated obese

  6. Prevalência e gravidade de asma brônquica em adultos obesos com indicação de cirurgia bariátrica Prevalence and severity of asthma in obese adult candidates for bariatric surgery

    Directory of Open Access Journals (Sweden)

    Saulo Maia Davila Melo

    2011-06-01

    Full Text Available OBJETIVO: Determinar a prevalência de asma em um grupo de adultos obesos, candidatos a cirurgia bariátrica e avaliar a gravidade da asma neste grupo de pacientes. MÉTODOS: Estudo transversal, envolvendo 363 pacientes obesos adultos (índice de massa corpórea > 35 kg/m² avaliados por um médico pneumologista, utilizando a avaliação clínica como instrumento diagnóstico de asma. Todos os pacientes foram submetidos à avaliação clínica e espirometria e foram divididos em dois grupos (asma e controle. Os pacientes com asma foram classificados conforme a gravidade da doença. RESULTADOS: A prevalência de asma na população de obesos estudada foi de 18,5% (IC95%: 14,5-22,4. Essa prevalência nas mulheres e nos homens foi de 20,4% (IC95%: 16,2-24,5 e 13,7% (IC95%: 10,1-17,2, respectivamente. Havia sintomas de asma nos últimos doze meses em 8,0% (IC95%: 5,2-10,7, e houve manifestação inicial dos sintomas de asma na infância/adolescência em 17,4% (IC95%: 13,5-21,3. No grupo asma, asma intermitente estava presente em 29 pacientes (43,3%; asma persistente leve, em 7 (10,4%; asma moderada, em 25 (37,3%; e asma persistente grave, em 6 (9,0%. CONCLUSÕES: A prevalência de asma neste grupo de adultos obesos, utilizando-se a avaliação clínica como critério diagnóstico, mostrou-se elevada, com predomínio no sexo feminino e com manifestação inicial dos sintomas de asma na infância/adolescência. A gravidade da asma neste grupo de obesos adultos esteve entre os valores médios estimados para a população geral, com uma maior proporção de asma intermitente, asma persistente leve e asma persistente moderadaOBJECTIVE: To determine the prevalence of asthma in a group of obese adult candidates for bariatric surgery and to evaluate the severity of asthma in this group of patients. METHODS: This was a cross-sectional study involving 363 obese adults (body mass index > 35 kg/m² evaluated by a pulmonologist, using clinical evaluation as a

  7. Moisture sources of the Mono Lake deglacial pluvial events

    Science.gov (United States)

    Wang, X.; Liang, M. C.; Ali, G.; Shen, C. C.; Cai, Y.; Ke, L.; Hemming, S. R.

    2016-12-01

    Enormously expanded lakes existed in the today's dry western US Great Basin during the last glacial period. The ancient shorelines located well above modern lake levels suggest that precipitation in lake basins must have been substantially higher in the past. It is however under debate whether the subtropical North Pacific or the tropical Pacific is the major moisture source that contributed to the pluvial events, particularly during the deglaciation. Here, we collected a suite of tufa carbonate samples deposited at the 2,080 meter terrace ( 135 meters above today's lake level) in the Mono Basin, California, a closed lake basin for the last 130 thousand years (kyr). At Goat Ranch, we discovered white, shiny, laminated botryoidal carbonate coatings on tufa mounds. Most of these coatings present two generations of formation separated by a hiatus, which indicates lake level fluctuations. Using high-precision U-Th dating techniques, we found that the lower layer was formed 14.1-14.4 kyr BP (corresponding to the North Atlantic Bølling warming period). The upper layer of the coating was formed 11.9-12.3 kyr BP (within the Younger Dryas event). We then obtained d18O, d13C, D47 and 17O-excess values for the two carbonate layers. The upper part is characterized by low d18O values, -8 to -12 ‰ VPDB, whereas the lower one has higher d18O values, -5 to -6 ‰ VPDB. Both share similar d13C values ( 1-2‰ VPDB). D47 analysis on the carbonates suggests that both layers were deposited in a water temperature of 9±2 oC (1s, n = 4 and 8, respectively). The two generations of carbonates present 17O-excess of moisture in values of 50±5 (1s, n=4) and 25±5 (1s, n=8) per meg VSMOW-SLAP, respectively. The large difference in 17O-excess of parent meteoric water points to different origins of moisture for the tufa carbonate formations. The high 17O-excess values during YD suggest a moisture source with a low relative humidity, consistent with the conventional view that the moisture

  8. Homoleptic mono- and dinuclear cationic alkoxydiphosphazane derivatives of rhodium

    International Nuclear Information System (INIS)

    Edwards, K.J.; Haines, R.J.; Meintjies, E.; Sigwarth, B.

    1990-01-01

    Treatment of the solvento species [Rh(C 8 H 12 )(solvent) 2 ][SbF 6 ] (solvent = methanol, ethanol, or tetrahydrofuran) with a twice-molar amount of the diphosphazane ligands (RO) 2 PN(R') P(OR) 2 (R' = Me or Et; R = Me, Et, or Pr i ) in the appropriate solvent leads to the ready formation of monocationic [Rh{(RO) 2 PN(R')P(OR) 2 } 2 ] + and/or dicationic [Rh 2 {μ-(RO) 2 PN(R')P(OR) 2 } 2 {(RO) 2 PN(R')P(OR) 2 } 2 ] 2+ hexafluoroantimonate salts, with the tendency to afford dinuclear derivatives decreasing along the series Me>Et>Pr i . Carbon monoxide readily forms addition products with these ionic species, giving rise to five-coordinate derivatives of the type [Rh(CO){(RO) 2 PN(R')P (OR) 2 } 2 ][SbF 6 ] in the case of the mononuclear derivatives, and inserting across the two rhodium atoms to afford [Rh 2 (μ-CO){μ-(MeO) 2 PN(Et)P(OMe) 2 } 2 {(MeO) 2 PN(Et)P(OMe) 2 } 2 ][SbF 6 ] 2 in the case of [Rh 2 {μ-(MeO) 2 PN (Et)P(OMe) 2 } 2 {(MeO) 2 PN(Et)P(OMe) 2 } 2 ][SbF 6 ] 2 . These mono- and dicationic derivatives also react readily with iodine affording [RhI 2 {(RO) 2 PN(R')P(OR) 2 } 2 ][SbF 6 ] and [Rh 2 (μ-I){μ-(MeO) 2 PN(Et)P(OMe) 2 } 2 {(MeO) 2 PN(Et)P(OMe) 2 } 2 ][SbF 6 ] n (n = 2 or 3) respectively. The coordination behaviour of the diphosphorus ligands (MeO) 2 PCH 2 P(OMe) 2 and Me 2 PCH 2 PMe 2 towards [Rh(C 8 H 12 )(solvent) 2 ][SbF 6 ] has also been investigated. 1 fig., 1 tab., 19 refs

  9. 7th to 9th grade obese adolescents’ perceptions about obesity in tamaulipas, Mexico Percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado residentes en Tamaulipas, México Percepções da obesidade de adolescentes obesos, estudantes do 7º ao 9º grau residentes em Tamaulipas, México

    OpenAIRE

    Ma. de la Luz Martínez-Aguilar; Yolanda Flores-Peña; Ma. de las Mercedes Rizo-Baeza; Rosa Ma. Aguilar-Hernández; Laura Vázquez-Galindo; Gustavo Gutiérres-Sánchez

    2010-01-01

    The objective was to explore obese adolescents’ perceptions about obesity among students in the seventh to ninth grade of a public school in Tamaulipas, Mexico. This is a qualitative study. Participants were 24 adolescents with a body mass index equal to or greater than the 95th percentile. Semistructured interviews were conducted until data saturation was reached and the meaning was understood. The adolescents defined obesity according to standards of measurement. They identified the heredit...

  10. Variação do diâmetro da artéria braquial em crianças obesas: presente e futuro Variación del diámetro de la arteria braquial en niños obesos: presente y futuro Variation of the brachial artery diameter in obese children: present and future

    Directory of Open Access Journals (Sweden)

    Karla Cristina M. Costa

    2012-09-01

    Full Text Available OBJETIVO: Revisão da literatura acerca do uso da medida da variação do diâmetro da artéria braquial por ultrassonografia de alta resolução (dilatação mediada por fluxo como preditor de risco para doença cardiovascular em crianças e adolescentes obesos. FONTES DE DADOS: Levantamento de publicações indexadas no Medline/PubMed de trabalhos publicados entre 2002 e 2011, rastreadas com a combinação dos descritores: "endothelium", "child", "ultrasonography" e "obesity", além de estudos e textos clássicos sobre o tema. Foram encontradas 54 publicações e 32 delas foram incluídas na presente revisão do tema. SINTESE DOS DADOS: O estudo da disfunção endotelial tem sido empregado como preditor de risco para doenças cardiovasculares, tais como aterosclerose e doença cardíaca coronariana, visto que a lesão endotelial é um importante evento na fisiopatologia de tais doenças. CONCLUSÕES: A dilatação mediada por fluxo da artéria braquial mostra-se importante como ferramenta diagnóstica e prognóstica na avaliação da função endotelial de crianças e adolescentes com excesso de peso por ser um método não invasivo, com boa aplicabilidade quanto ao custo, à inocuidade e ao benefício.OBJETIVO: Revisión de la literatura sobre el uso de la medida de la variación del diámetro de la arteria braquial, por ultrasonografía de alta resolución (dilatación mediada por flujo, como predictor de riesgo para enfermedad cardiovascular en niños y adolescentes obesos. FUENTES DE DATOS: Inventario de publicaciones indizadas en Medline/Pubmed de trabajos publicados entre 2002 y 2011, buscadas mediante la combinación de los descriptores: «endothelium», «child», «ultrasonography» y «obesity», además de estudios y textos clásicos sobre el tema. Se encontraron 54 publicaciones y 32 de ésas fueron incluidas en la presente revisión del tema. Síntesis de los datos: El estudio de la disfunción endotelial viene siendo empleado

  11. Crianças e adolescentes obesos: dois anos de acompanhamento interdisciplinar Obese children and adolescents: two years of interdisciplinary follow-up

    Directory of Open Access Journals (Sweden)

    Mariana Porto Zambon

    2008-06-01

    Full Text Available OBJETIVO: Avaliar dois anos de seguimento de crianças e adolescentes obesos em ambulatório especializado. MÉTODOS: Trata-se de coorte, com coleta retrospectiva dos dados de 150 pacientes (1 a 19 anos de idade do Ambulatório de Obesidade do Hospital de Clínicas da Universidade Estadual de Campinas. Destes pacientes, 53% eram do sexo masculino e 63% eram de Campinas, São Paulo. A média da idade no início de ganho de peso foi 4,3 anos. Dos 150 pacientes, 128 retornaram uma vez, com avaliação de peso, altura, índice de massa corpórea (IMC e escores Z. Foram realizados hemograma, glicemia de jejum, insulina basal, relação glicemia/insulina, triglicérides, colesterol total e frações. Os pacientes foram divididos em dois grupos, de acordo com o seguimento. Entre os grupos, foi analisada a diferença entre idade, sexo, procedência, idade de início, acantose nigricans e os escores Z de peso, altura e IMC, proporção de exames laboratoriais alterados e a diferença dos escores Z de IMC em relação à primeira consulta. RESULTADOS: Dos 128 pacientes, 57% permaneceram em seguimento, sendo que 114 retornaram pelo menos uma vez. Comparando os grupos, os moradores de Campinas foram os que mais abandonaram o ambulatório, sem diferenças em relação às demais variáveis clínicas, antropométricas e laboratoriais estudadas. Houve queda da média do escore Z do IMC em ambos os grupos, em relação à consulta inicial. CONCLUSÕES: Os pacientes deste estudo apresentaram redução da média do escore Z do IMC semelhante à literatura. Apesar do alto índice de abandono, não foram identificados fatores de risco que o justificassem, com exceção da procedência da criança.OBJECTIVE: To study two years follow-up of obese children and adolescents from a specialized out-patient clinic. METHODS: This cohort study with retrospective collection of data enrolled 150 patients (1 to 19 years old, 53% males, 63% from Campinas, São Paulo, Brazil, and

  12. Comparison between mono-bloc and bi-bloc mandibular advancement devices for obstructive sleep apnea.

    Science.gov (United States)

    Lee, Woo Hyun; Wee, Jee Hye; Lee, Chul Hee; Kim, Min-Su; Rhee, Chae-Seo; Yun, Pil-Young; Yoon, In-Young; Kim, Jeong-Whun

    2013-11-01

    Although mandibular advancement device (MAD) is widely used, there are a few papers comparing the efficacy and compliance at the same time according to the type of MAD. The aim of this study is to compare the efficacy and compliance between mono-bloc and bi-bloc MAD in the treatment of obstructive sleep apnea (OSA). Ninety-three patients who treated with mono-bloc MAD and 60 patients with bi-bloc MAD from January 2007 through September 2011 were retrospectively enrolled. All the patients underwent full-night polysomnography(PSG) before and 3 months after MAD was applied. The response rate was significantly higher in the patients using mono-bloc than those using bi-bloc MAD (77.4 vs. 58.3 %; P = 0.012). In contrast, the compliance rate of MAD use was significantly higher in the patients using bi-bloc than those using mono-bloc MAD (68.8 vs. 83.3 %; P = 0.044) at 1 year. According to the severity of OSA, the response rate was significantly higher in severe OSA than in mild to moderate OSA (P = 0.033 for mono-bloc MAD and P = 0.048 for bi-bloc MAD). However, there was no difference in the compliance between mild to moderate OSA and severe OSA. Our study showed that mono-bloc MAD was superior to bi-bloc MAD in efficacy while bi-bloc MAD is superior to mono-bloc MAD in compliance. We propose that both the efficacy and compliance should be considered in using MAD for treatment of OSA.

  13. Alteraciones metabólicas en pacientes obesos y su asociación con la acantosis nigricans Metabolic alterations in obese patients and its association with the acanthosis nigricans

    Directory of Open Access Journals (Sweden)

    Marlen Rivero González

    2012-03-01

    Full Text Available Introducción: la obesidad se considera actualmente una epidemia en aumento a escala mundial. El fenómeno afecta a niños y adultos, y se asocia con la aparición precoz de enfermedades crónicas no trasmisibles que antes parecían exclusivas de los adultos, pero que se pueden presentar, incluso, en edades tempranas de la vida. Objetivo: identificar alteraciones clínicas y metabólicas en pacientes obesos y su asociación con la acantosis nigricans. Métodos: se realizó un estudio longitudinal prospectivo con 60 pacientes diagnosticados con obesidad exógena, con o sin acantosis nigricans, en el período comprendido de enero de 2009 a enero de 2010 en el servicio de endocrinología del Hospital Docente "William Soler". Se les realizó, además de anamnesis y examen físico, prueba de tolerancia a la glucosa, con determinación de glucemia e insulinemia en ayunas y a las 2 horas, determinación de colesterol, triglicéridos y ultrasonido del hígado. Resultados: el 55 % de los pacientes estudiados presentaban acantosis nigricans. La hipertensión arterial (18,2 %, así como el hiperinsulinismo (21,2 %, predominaron en este grupo de pacientes. La prueba de tolerancia a la glucosa alterada (6 %, las alteraciones de los lípidos (27,2 % y la esteatosis hepática (39 % predominaron en los pacientes obesos con acantosis nigricans. Conclusiones: la obesidad en edad pediátrica puede constituir un riesgo elevado de sufrir complicaciones metabólicas, sobre todo, en el obeso con acantosis nigricans.Introduction: nowadays, obesity is considered a worldwide increasing epidemic. This phenomenon involves children and adults and it is associated with the early appearance of non-communicable chronic diseases that in the past were exclusive of adults, but that may be present in early ages of life. Objective: to identify the clinical and metabolic alterations in obese patients and its association with acanthosis nigricans. Methods: a prospective and

  14. El mono gramático y el sabio alquimista. Algunas reflexiones en torno a la poética de Octavio Paz en El Mono Gramático

    Directory of Open Access Journals (Sweden)

    Óscar Pujol

    2014-04-01

    Full Text Available El presente artículo es una comparación entre la poética de Octavio Paz en El Mono Gramático y un autor indio del siglo XI Abhinavagupta, a quien llamamos el Sabio Alquimista en referencia a la teoría india de la emoción estética: el rasa. Una idea subyacente en ambos autores es que el lenguaje ordinario enmascara la realidad, mientras que el lenguaje poético se resuelve en una abolición de la escritura que nos enfrenta a una realidad indecible. Se comparan un total de seis características distintas y se llega a la conclusión que la mayor discrepancia entre ambos autores es la naturaleza de esa realidad innombrable que revela la poesía. Para el autor indio se trata de una realidad inefable y gozosa: la conciencia pura. Para Paz es una realidad insoportable y enloquecedora, aunque al mismo tiempo fascinante. La diferencia es cultural, pues la tradición india adora a esa realidad innombrable mientras que la modernidad occidental desconfía de un absoluto inmensurable e impositivo. En este sentido Paz ejemplifica el dilema del hombre moderno: angustia ante esa realidad anterior al lenguaje, pero también una fascinación que busca en el arte y la poesía su modo último de expresión.

  15. [Technique of complex mammary irradiation: Mono-isocentric 3D conformational radiotherapy and helical tomotherapy].

    Science.gov (United States)

    Vandendorpe, B; Guilbert, P; Champagne, C; Antoni, T; Nguyen, T D; Gaillot-Petit, N; Servagi Vernat, S

    2017-12-01

    To evaluate the dosimetric contribution of helical tomotherapy for breast cancers compared with conformal radiotherapy in mono-isocentric technique. For 23 patients, the dosimetric results in mono-isocentric 3D conformational radiotherapy did not satisfy the constraints either of target volumes nor organs at risk. A prospective dosimetric comparison between mono-isocentric 3D conformational radiotherapy and helical tomotherapy was therefore carried out. The use of helical tomotherapy showed a benefit in these 23 patients, with either an improvement in the conformity index or homogeneity, but with an increase in low doses. Of the 23 patients, two had pectus excavatum, five had past thoracic irradiation and two required bilateral irradiation. The other 14 patients had a combination of morphology and/or indication of lymph node irradiation. For these patients, helical tomotherapy was therefore preferred to mono-isocentric 3D conformational radiotherapy. Tomotherapy appears to provide better homogeneity and tumour coverage. This technique of irradiation may be justified in the case of morphological situations such as pectus exavatum and in complex clinical situations. In other cases, conformal radiotherapy in mono-isocentric technique remains to be favoured. Copyright © 2017 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  16. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Riou, Laurent; Ghezzi, Catherine [Universite Joseph Fourier, Grenoble (France); INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Poillot, Cathy; Cestele, Sandrine [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Desruet, Marie-Dominique [INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Couvet, Morgane; Bourgoin, Sandrine; Seve, Michel [CRI-INSERM U823, Grenoble (France). Inst. of Albert Bonniot; Universite Joseph Fourier, Grenoble (France); Waard, Michel de [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Smartox Biotechnologies, Grenoble (France)

    2014-07-01

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen {sup registered} or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H{sub 2}O{sub 2} was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  17. PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.

    Science.gov (United States)

    Suzuki, Motoshi; Niimi, Atsuko; Limsirichaikul, Siripan; Tomida, Shuta; Miao Huang, Qin; Izuta, Shunji; Usukura, Jiro; Itoh, Yasutomo; Hishida, Takashi; Akashi, Tomohiro; Nakagawa, Yoshiyuki; Kikuchi, Akihiko; Pavlov, Youri; Murate, Takashi; Takahashi, Takashi

    2009-07-01

    Translesion DNA synthesis (TLS) involves PCNA mono-ubiquitination and TLS DNA polymerases (pols). Recent evidence has shown that the mono-ubiquitination is induced not only by DNA damage but also by other factors that induce stalling of the DNA replication fork. We studied the effect of spontaneous DNA replication errors on PCNA mono-ubiquitination and TLS induction. In the pol1L868F strain, which expressed an error-prone pol alpha, PCNA was spontaneously mono-ubiquitinated. Pol alpha L868F had a rate-limiting step at the extension from mismatched primer termini. Electron microscopic observation showed the accumulation of a single-stranded region at the DNA replication fork in yeast cells. For pol alpha errors, pol zeta participated in a generation of +1 frameshifts. Furthermore, in the pol1L868F strain, UV-induced mutations were lower than in the wild-type and a pol delta mutant strain (pol3-5DV), and deletion of the RAD30 gene (pol eta) suppressed this defect. These data suggest that nucleotide misincorporation by pol alpha induces exposure of single-stranded DNA, PCNA mono-ubiquitination and activates TLS pols.

  18. Esteatose hepática não alcoólica: relação com a síndrome metabólica e os fatores de risco cardiovascular em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Wener Barbosa Resende

    2014-03-01

    Full Text Available Objetivo: Avaliar a associação entre esteatose hepática não alcoólica (EHNA, síndrome metabólica (SM e fatores de risco cardiovascular (FRCs em adolescentes obesos. Métodos: Estudo observacional do tipo transversal com abordagem quantitativa, realizado de junho a agosto de 2011. Os voluntários foram aleatoriamente selecionados e encaminhados para avaliação clínica no setor de endocrinologia e cardiologia do hospital de clínicas da Universidade Federal de Uberlândia. Participaram 34 adolescentes de 14 a 19 anos, acima do percentil 95 da curva de crescimento. A EHNA foi analisada por ultrassonografia. A SM e os FRCs foram identificados pelos critérios da International Diabetes Federation. Resultados: A amostra foi composta de 14 indivíduos do sexo masculino e 20 do sexo feminino, com idade (16,8±1,6 e índice de massa corporal (IMC (35,7±3,9. A ocorrência de EHNA e SM foi de 76,5% (n=26 e 50% (n=17, respectivamente. O sexo masculino apresentou maior ocorrência de EHNA (78,6%, n=11, SM (64,3%, n=09 e associação de EHNA com SM (50%, n=07. Em relação aos FRCs 100% (n=34, 61,8% (n=21 e 52,9% (n=18 dos adolescentes apresentaram valores aumentados da circunferência da cintura (CC, da lowdensity- lipoprotein cholesterol (LDL-C e pressão arterial sistólica (PAS, respectivamente, e 52,9% (n=18 apresentaram baixos valores de high-density lipoprotein cholesterol (HDL-C. Houve correlações entre SM e triglicerídeos, PAS e diastólica e HDL-C, e entre EHNA, IMC e CC. Conclusão: Observou-se uma alta ocorrência de EHNA, SM e FRCs em adolescentes obesos. Uma forte correlação foi observada entre EHNA e SM, e entre FRCs com EHNA e SM.

  19. Imagem corporal, ansiedade e depressão em pacientes obesos submetidos à cirurgia bariátrica Body image, anxiety and depression in obese patients submitted to bariatric surgery

    Directory of Open Access Journals (Sweden)

    Sebastião Sousa Almeida

    2012-04-01

    Full Text Available Pacientes obesos mórbidos têm recorrido à cirurgia bariátrica como um recurso eficaz para perder peso. Entretanto, este procedimento pode causar alterações comportamentais significativas. O objetivo deste trabalho foi investigar os níveis de ansiedade e depressão, assim como as mudanças sofridas na percepção da imagem corporal em pacientes obesos submetidos à cirurgia bariátrica em três momentos: pré-operatório, 6 meses e 12 meses após a cirurgia. Trata-se de um estudo do tipo prospectivo longitudinal, de abordagem quantitativa. No estudo foram aplicados os Inventários de Depressão e Ansiedade de Beck e a Escala Brasileira de Figuras de Silhuetas para Adultos. A cirurgia diminuiu significativamente tanto o índice de massa corporal dos pacientes quanto a insatisfação com a sua imagem corporal. Essa perda de peso e diminuição da insatisfação com a imagem corporal foi acompanhada de redução nos níveis de ansiedade e depressão, o que sugere que estes são fatores importantes no quadro obesidade.Morbidly obese patients often have resorted to bariatric surgery as an effective resource to be used for weight loss. However, this procedure can cause significant behavioral changes. The objective of this study was to investigate levels of anxiety and depression, as well as the changes suffered in the perception of body image in obese patients undergoing bariatric surgery at three different times: preoperatively, 6 months and 12 months after surgery. This is a prospective longitudinal study of a quantitative approach. The study used the Beck Depression Inventory, the Beck Anxiety Inventory and the Brazilian Scale of Figures Silhouettes for Adults. Surgery significantly decreased both the body mass index of patients and dissatisfaction with their body image. This weight loss and decreased body image dissatisfaction was accompanied by reduced levels of anxiety and depression, suggesting that these are important factors in the

  20. Índice glicêmico e carga glicêmica de dietas consumidas por indivíduos obesos Glycemic index and glycemic load of diets consumed by obese individuals

    Directory of Open Access Journals (Sweden)

    Helena Alves de Carvalho Sampaio

    2007-12-01

    Full Text Available OBJETIVO: Avaliar o índice glicêmico e a carga glicêmica de dietas de indivíduos obesos. MÉTODOS: Trata-se de estudo retrospectivo, que analisou as fichas clínicas de 80 adultos obesos, acompanhados em um serviço privado localizado em Fortaleza, Ceará. Determinaram-se o índice glicêmico e a carga glicêmica da dieta. Para verificação da associação entre índice glicêmico e carga glicêmica, e dessas variáveis com a ingestão energética diária e com o índice de massa corporal dos indivíduos, utilizou-se o teste de correlação de Pearson. O teste "t" de Student foi utilizado para verificar diferenças entre os dois índices e o sexo. Em ambos os testes adotou-se pOBJECTIVE: To evaluate the glycemic index and glycemic load of diets of obese individuals. METHODS: This is a retrospective study that analyzed the medical records of 80 obese adults attending a private health care service in Fortaleza, Ceará. The glycemic index and load of their diet was determined. The Pearson correlation test was used to verify if there was an association between glycemic index and glycemic load and of these variables with their daily energy intake and body mass index. The Student's "t" test was used to verify the differences between the two indexes and gender. A significance level of p<0.05 was adopted for both tests. RESULTS: Inadequate (moderate or high glycemic index prevailed at breakfast (82.9%, afternoon snack (60.0% and dinner (64.6%. The daily glycemic index was inadequate for 78.7% of the group and predominantly moderate according to the mean found (59.23, however it was less inadequate than the daily glycemic load which was high (143.8 and worse among males. The body mass index of the group, in general and according to gender, was not associated with any of the indices. Daily energy intake was associated only with glycemic load, both generally and taking gender into account. CONCLUSION: The results point toward a higher glycemic load in

  1. Evaluation of efficacy, reliability, and tolerability of sibutramine in obese patients, with an echocardiographic study Avaliação da eficácia, segurança e tolerabilidade da sibutramina em obesos - estudo randomizado duplo-cego

    Directory of Open Access Journals (Sweden)

    Alfredo Halpern

    2002-06-01

    Full Text Available This is a double-blind, placebo-controlled study of the efficacy, safety, and tolerability of sibutramine in the management of obese patients for a 6-month period. METHOD: Sixty-one obese patients (BMI >30, 10%, we observed a weight loss of >5% in 40% of the patients on sibutramine compared with 12.9% in the placebo group. We also detected weight gain in 45.2% of the placebo group compared to 20% in the sibutramine group. The sibutramine group showed improvement in HDL- cholesterol values (increased by 17% and triglyceride values (decreased by 12.8%. This group also showed an increase in systolic blood pressure (6.7%, 5 mmHg. There were no changes in echocardiograms comparing the beginning and end of follow-up, and side effects did not lead to discontinuation of treatment. DISCUSSION: Sibutramine proved to be effective for weight loss providing an 8% loss of the initial weight. Compliance to prolonged treatment was good, and side effects did not result in discontinuation of treatment. These data confirmed the good efficacy, tolerability, and safety profiles of sibutramine for treatment of obesity.O presente estudo objetivou comparar a eficácia, segurança e tolerabilidade da sibutramina em pacientes obesos. MÉTODO: Selecionamos 61 pacientes obesos (3010% ocorreu perda de peso>5% em 40% dos pacientes em uso da sibutramina vs 12,9% no grupo placebo e ganho de peso em 45,2% dos pacientes em uso de placebo vs 20% no grupo sibutramina. No grupo sibutramina notamos melhora dos níveis de HDL-colesterol (aumento de 17% e triglicerídeos (diminuição de 12,8%, neste grupo ocorreu também um aumento da pressão arterial sistólica (6,7%-5mmHg. Não houve alteração entre os ecocardiogramas do início e final do acompanhamento e os efeitos adversos não levaram à descontinuação do tratamento. DISCUSSÃO: A sibutramina mostrou-se eficaz na redução de peso, proporcionando um perda de 8% em relação ao peso inicial. Houve boa adesão do paciente ao

  2. Função diastólica do ventrículo esquerdo em obesos graves em pré-operatório para cirurgia bariátrica

    Directory of Open Access Journals (Sweden)

    Irlaneide da Silva Tavares

    2012-04-01

    Full Text Available FUNDAMENTO: Obesidade é uma doença crônica, multifatorial, associada a aumento do risco cardiovascular, especialmente a insuficiência cardíaca diastólica. OBJETIVO: Avaliar a função diastólica do ventrículo esquerdo em obesos graves em pré-operatório para cirurgia bariátrica, relacionando com os fatores de risco cardiovascular e a estrutura cardíaca. MÉTODOS: Trata-se de um estudo transversal, com 132 pacientes candidatos a cirurgia bariátrica, submetidos a avaliação ecocardiográfica transtorácica e dos fatores de risco cardiovascular, sendo: 97 mulheres (73,5%, idade média de 38,5 ± 10,5 anos e IMC de 43,7 ± 7,2 Kg/m². Foram divididos em três grupos: 61 com função diastólica normal, 24 com disfunção diastólica leve e 47 com disfunção diastólica moderada/grave, dos quais 41 com disfunção diastólica moderada (padrão pseudonormal e seis com disfunção diastólica grave (padrão restritivo. RESULTADOS: Hipertensão arterial sistêmica, idade e gênero foram diferentes nos grupos com disfunção diastólica. Os grupos com disfunção tiveram maior diâmetro do átrio esquerdo, do ventrículo esquerdo, volume do átrio esquerdo em quatro e duas câmaras, índice de volume atrial esquerdo e índice de massa do ventrículo esquerdo corrigido para a superfície corpórea e para altura. CONCLUSÃO: A elevada frequência de disfunção diastólica do ventrículo esquerdo na fase pré-clínica em obesos graves justifica a necessidade de uma avaliação ecocardiográfica criteriosa, com o objetivo de identificar indivíduos de maior risco, para que medidas de intervenção precoce sejam adotadas.

  3. Ti, Al

    Indian Academy of Sciences (India)

    In the present study, authors report on the effect that substrate bias voltage has on the microstructure and mechanical properties of (Ti, Al)N hard coatings deposited with cathodic arc evaporation (CAE) technique. The coatings were deposited from a Ti0.5Al0.5 powder metallurgical target in a reactive nitrogen atmosphere at ...

  4. Direct Determination of the Absorption of Graphene Mono- and Multi-layers in the Visible and Near-Infrared

    Science.gov (United States)

    Wu, Yang; Mak, Kin Fai; Lui, Chun Hung; Maultzsch, Janina; Heinz, Tony

    2008-03-01

    Single-crystal mono- and multi-layer graphene samples were prepared by mechanical exfoliation on quartz substrates. The absorption spectra of samples of 1 -- 8 monolayer thickness were measured in the optical and near-infrared range. The absorption coefficient was found to be largely independent of photon energy and linear in the number of graphene layers. Such absorption measurements can thus be used to determine the thickness of mesoscopic graphite to monolayer accuracy, as already demonstrated in the context of Rayleigh scattering [Casiraghi et al. Nano Letters 2007]. By analysis of the optical transmission problem for a thin film at the air-quartz interface, we deduced an absorption of 2.3% per layer. The magnitude of the monolayer absorption agrees with the value of πα, where α is the fine-structure constant, and corresponds the result obtained from a tight-binding model of the graphene electronic structure [Gusynin et al. PRL 2006]. The predicted (and measured) optical absorption, we note, is equivalent to a constant optical conductance ofπe^22h=6.09x10-5φ-1.

  5. Efeitos de misturas de napropamide e simazine no controle de mono e dicotiledoneas em cafeeiros novos Effects of napropamide and simazine mixtures on the control of mono and dicotyledon on new coffee trees

    Directory of Open Access Journals (Sweden)

    L.S.P. Cruz

    1980-12-01

    : napropamide at 2.00 and 3.00 kg/ha; simazine at 0.50 and 0.75 kg/ha; and tank mixtures of 2.00 kg/ha of napropamide with 0.50 and 0.75 kg/ha of simazine; and 3.00 kg/ha of napropamide also with 0.50 and 0.75 kg/ha of simazine. A treatment without herbicide was also included in the experiment. A weed count was done 45 days after the aplication of the herbicides, and every 15 days until the 90th day, visual observations were done to detect the percentage of weed infestations. At that time it was also done on the fitotoxicity symptoms caused by herbicides on the coffee trees. The most frequent weeds present in the trial were, Digitaria horizontalis Willd. Eleusine indica (L . Gaertn, Amaranthus viridis L. and Bidens pilosa L. As it was expected, the mixtures were much more effective than those alone. The mixtures were rather effective in the control of mono and dycotyledons which were present in the experiment. Al treatments with 0.75 kg/ha of simazine presented light symptoms of fitotoxicity, limited to some leaves of the coffee trees, till last observation.

  6. Comparison Spatial Pattern of Land Surface Temperature with Mono Window Algorithm and Split Window Algorithm: A Case Study in South Tangerang, Indonesia

    Science.gov (United States)

    Bunai, Tasya; Rokhmatuloh; Wibowo, Adi

    2018-05-01

    In this paper, two methods to retrieve the Land Surface Temperature (LST) from thermal infrared data supplied by band 10 and 11 of the Thermal Infrared Sensor (TIRS) onboard the Landsat 8 is compared. The first is mono window algorithm developed by Qin et al. and the second is split window algorithm by Rozenstein et al. The purpose of this study is to perform the spatial distribution of land surface temperature, as well as to determine more accurate algorithm for retrieving land surface temperature by calculated root mean square error (RMSE). Finally, we present comparison the spatial distribution of land surface temperature by both of algorithm, and more accurate algorithm is split window algorithm refers to the root mean square error (RMSE) is 7.69° C.

  7. Impact of temperature on performance of series and parallel connected mono-crystalline silicon solar cells

    Directory of Open Access Journals (Sweden)

    Subhash Chander

    2015-11-01

    Full Text Available This paper presents a study on impact of temperature on the performance of series and parallel connected mono-crystalline silicon (mono-Si solar cell employing solar simulator. The experiment was carried out at constant light intensity 550 W/m2with cell temperature in the range 25–60 oC for single, series and parallel connected mono-Si solar cells. The performance parameters like open circuit voltage, maximum power, fill factor and efficiency are found to decrease with cell temperature while the short circuit current is observed to increase. The experimental results reveal that silicon solar cells connected in series and parallel combinations follow the Kirchhoff’s laws and the temperature has a significant effect on the performance parameters of solar cell.

  8. Imaging the magmatic system of Mono Basin, California with magnetotellurics in three--dimensions

    Science.gov (United States)

    Peacock, Jared R.; Mangan, Margaret T.; McPhee, Darcy K.; Ponce, David A.

    2015-01-01

    A three–dimensional (3D) electrical resistivity model of Mono Basin in eastern California unveils a complex subsurface filled with zones of partial melt, fluid–filled fracture networks, cold plutons, and regional faults. In 2013, 62 broadband magnetotelluric (MT) stations were collected in an array around southeastern Mono Basin from which a 3D electrical resistivity model was created with a resolvable depth of 35 km. Multiple robust electrical resistivity features were found that correlate with existing geophysical observations. The most robust features are two 300 ± 50 km3 near-vertical conductive bodies (3–10 Ω·m) that underlie the southeast and north-eastern margin of Mono Craters below 10 km depth. These features are interpreted as magmatic crystal–melt mush zones of 15 ± 5% interstitial melt surrounded by hydrothermal fluids and are likely sources for Holocene eruptions. Two conductive east–dipping structures appear to connect each magma source region to the surface. A conductive arc–like structure (resistivity (200 Ω·m) suggestive of a cooled connection. A third, less constrained conductive feature (4–10 Ω·m) 15 km deep extending to 35 km is located west of Mono Craters near the eastern front of the Sierra Nevada escarpment, and is coincident with a zone of sporadic, long–period earthquakes that are characteristic of a fluid-filled (magmatic or metamorphic) fracture network. A resistive feature (103–105 Ω·m) located under Aeolian Buttes contains a deep root down to 25 km. The eastern edge of this resistor appears to structurally control the arcuate shape of Mono Craters. These observations have been combined to form a new conceptual model of the magmatic system beneath Mono Craters to a depth of 30 km.

  9. Influência do treinamento aeróbio e anaeróbio na massa de gordura corporal de adolescentes obesos Influencia del entrenamiento aeróbico y anaeróbico en la masa grasa corporal de adolescentes obesos Influence of the aerobic and anaerobic training on the body fat mass in obese adolescents

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Fernandez

    2004-06-01

    Full Text Available O objetivo deste estudo foi verificar as influências do exercício aeróbio e anaeróbio na composição corporal de adolescentes obesos do sexo masculino. A amostra foi constituída de 28 adolescentes com idades entre 15 e 19 anos, que apresentavam obesidade grave. Os voluntários foram distribuídos aleatoriamente em três grupos: grupo I: exercício anaeróbio; grupo II: exercício aeróbio; e grupo III: controle. O grupo I realizou treinamento intervalado em cicloergômetro que consistiu de 12 "tiros" de 30" com máxima força e velocidade, pedalando com carga alta (0,8% do massa corporal x 25 watts e recuperação ativa de 3'; o grupo II realizou treinamento aeróbio em cicloergômetro pedalando com carga relativa ao limiar ventilatório por 50 minutos. Já o terceiro grupo funcionou como controle, sem atividade física. Todos os grupos tiveram orientação nutricional e o período de intervenção foi de 12 semanas (três meses. Os voluntários realizaram densitometria óssea com análise da composição corporal (DEXA e avaliações médicas e de aptidão física. Quando comparados os períodos inicial e final de intervenção foram observadas reduções nas variáveis massa corporal, IMC, na massa de gordura corporal total e de membros inferiores e na percentagem de gordura corporal de tronco nos grupos de exercício. Diferenças foram observadas entre os grupos I e III para os deltas percentuais de massa de gordura corporal total e de membros inferiores e na percentagem de gordura de membros inferiores. Os dados sugerem que o exercício físico, tanto aeróbio como anaeróbio, aliado à orientação nutricional, promove maior redução ponderal, quando comparado com a orientação nutricional somente, e que, neste estudo, o exercício anaeróbio foi mais eficiente para promover a diminuição da gordura corporal e da percentagem de gordura e o exercício aeróbio foi mais eficaz no sentido de preservar e/ou aumentar a massa magra e a

  10. Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats

    OpenAIRE

    Saito, Ryusuke; Muneta, Takeshi; Ozeki, Nobutake; Nakagawa, Yusuke; Udo, Mio; Yanagisawa, Katsuaki; Tsuji, Kunikazu; Tomita, Makoto; Koga, Hideyuki; Sekiya, Ichiro

    2017-01-01

    Background It is still debated whether strenuous running in the inflammatory phase produces beneficial or harmful effect in rat knees. We examined (1) the dropout rate of rats during a 30-km running protocol, (2) influences of strenuous running and/or low amounts of mono-iodoacetate injection on cartilage, and (3) the effect of strenuous running on synovitis. Methods Rats were forced to run 30?km over 6?weeks and the dropout rate was examined. One week after 0.1?mg mono-iodoacetate was inject...

  11. Method for separating mono- and di-octylphenyl phosphoric acid esters

    International Nuclear Information System (INIS)

    Arnold, W.D. Jr.

    1977-01-01

    A method for separating mono-octylphenyl phosphoric acid ester and di-octylphenyl phosphoric acid ester from a mixture thereof comprises reacting the ester mixture with a source of lithium or sodium ions to form a mixture of the phosphate salts; contacting the salt mixture with an organic solvent which causes the dioctylphenyl phosphate salt to be dissolved in the organic solvent phase and the mono-octylphenyl phosphate salt to exist in a solid phase; separating the phases; recovering the phosphate salts from their respective phases; and acidifying the recovered salts to form the original phosphoric acid esters

  12. Tritium enrichment from aqueous solutions using cryosublimation of mono- and polysaccharides

    International Nuclear Information System (INIS)

    Wierczinski, B.; Muellen, G.; Rosenhauer, S.

    2008-01-01

    Cryosublimation is one technique, which allows the accumulation of tritium from aqueous solutions using certain chemical compounds. After studying several inorganic compounds such as zeolites and metal salts, as well as some humic substances, we have now investigated several mono- and polysaccharides, such as glucose, maltose, galactose, starch, agar, and gelatine. Except for starch all of the above mentioned compounds showed a clear enrichment of tritium. The highest value was reached for Agartine, which gave an enrichment factor of 6.2. Since mono- and polysaccharides form weak hydrogen bonds, these results prove again our theory that tritium is preferably accumulated in exchangeable hydrogen bonds. (author)

  13. 2 keV filters of quasi-mono-energetic neutrons

    International Nuclear Information System (INIS)

    Adib, M.; Habib, N.; El-Mesiry, M.S.; Bashter, I.I.; Saleh, A.; Fathallah, M.

    2013-01-01

    A simulation study for the production of 2 keV filters of quasi-mono-energetic neutrons based on the deep interference minima in the 45 Sc total cross-section was carried out. A computer code QMENF-II was adapted to calculate the optimum amounts of the 45 Sc as a main filter element and additional component ones to obtain sufficient intensity at high resolution and purity of the filtered quasi-mono-energetic neutrons. The emitted neutron spectrum from nuclear reactor and from the reaction of 2.6 MeV protons on a lithium fluoride target at the accelerator beam port, are used for simulation

  14. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  15. Prevenção da síndrome metabólica em crianças obesas: uma proposta de intervenção Prevención del síndrome metabólico en niños obesos: una propuesta de intervención Prevention of metabolic syndrome in obese children: a proposal of intervention

    Directory of Open Access Journals (Sweden)

    Camila Buonani

    2011-06-01

    Full Text Available OBJETIVO: Analisar o efeito de 12 semanas de intervenção envolvendo prática de atividade física, orientações alimentar e psicológica sobre fatores de risco para o desenvolvimento da síndrome metabólica em crianças e adolescentes obesos. MÉTODOS: Estudo longitudinal com 23 crianças e adolescentes obesos, com idade entre seis e 16 anos (12,0±3,2 anos. Foram mensurados: gordura corporal total e de tronco, glicemia, colesterol total e triglicérides, pressão arterial sistólica e diastólica. Os jovens foram submetidos a três sessões semanais de 60 minutos de exercício físico (atividades esportivas recreativas, ginástica, circuitos e caminhadas, durante 12 semanas. O teste do qui-quadrado foi usado para comparar dados categóricos daqueles que apresentaram valores acima das recomendações para cada fator de risco. O teste t para dados pareados foi aplicado para comparar os dois momentos do estudo. RESULTADOS: Em indivíduos com alterações metabólicas no início do estudo, observou-se, após a intervenção, a diminuição de 11,6% na glicemia (105 para 93mg/dL; p=0,046 e de 24,9% no triglicérides (217 para 163mg/dL; p=0,013; porém, não houve diferenças na pressão arterial e no colesterol total. CONCLUSÕES: O programa de exercício físico aplicado nas crianças e adolescentes foi eficiente para melhorar os valores de glicemia e triglicérides.OBJETIVO: Analizar el efecto de 12 semanas de intervención implicando práctica de actividad física, orientación alimentar y psicológica sobre factores de riesgo respecto al desarrollo del síndrome metabólico en niños y adolescentes obesos. MÉTODOS: Estudio longitudinal con 23 niños y adolescentes obsesos, con edad entre seis y 16 años (12,0±3,2 años. Se midió: grasa corporal total y de tronco, glucemia, colesterol total y triglicéridos, presión arterial sistólica y diastólica Los jóvenes fueron sometidos a tres sesiones semanales de 60 minutos de ejercicio f

  16. The Mono Lake geomagnetic excursion recorded in loess: Its application as time marker and implications for its geomagnetic nature

    Science.gov (United States)

    Hambach, U.; Hark, M.; Zeeden, C.; Reddersen, B.; Zöller, L.; Fuchs, M.

    2009-04-01

    One of the youngest and worldwide documented geomagnetic excursions in the Brunhes Chron is the Mono Lake excursion (MLE). It has been detected in marine and terrestrial sedimentary archives as well as in lavas. Recent age determinations and age estimates for the MLE centre around an age interval of approximately 31 - 34 ka. Likewise the Laschamp excursion the MLE goes along with a distinct peak in cosmogenic radionuclides in ice cores and sedimentary archives. It provides therefore an additional geomagnetic time marker for various geoarchives to synchronise different climate archives. Here we report on a detailed record of the MLE from a loess site at Krems, Lower Austria. The site is situated on the southern slope of the Wachtberg hill in the vicinity of the old city centre of Krems. The archive comprises Middle to Upper Würmian (Late Pleistocene) loess in which an Upper Palaeolithic (Early Gravettian) cultural layer is embedded. The most spectacular finds are a double infant burial found in 2005 and a single burial discovered in 2006 (Einwögerer et al., 2006). Generally, archaeological findings show an extraordinarily good preservation due to embedding in rapidly sedimented loess (Händel et al., 2008). The about 10 m thick loess pile consists of calcareous sandy, coarse silt which is rich in mica indicating local sources. It is well stratified with brownish horizons representing embryonic soils pointing to incipient pedogenesis. Some of the pedo-horizons show occasionally indications of minor erosion and bedding-parallel sediment transport, but no linear erosional features. Pale greyish horizons are the result of partial gleying under permafrost conditions. No strong pedogenesis including decalcification and clay formation is present. The cultural layer is still covered by more than 5 m of loess, and dated by radiocarbon to ~27 ka 14C BP (Einwögerer et al., 2006). Below this layer up to 2.5 m of loess resting on Lower Pleistocene fluvial gravels are

  17. Three-Dimensional Analysis of dike/fault interaction at Mono Basin (California) using the Finite Element Method

    Science.gov (United States)

    La Marra, D.; Battaglia, M.

    2013-12-01

    Mono Basin is a north-trending graben that extends from the northern edge of Long Valley caldera towards the Bodie Hills and is bounded by the Cowtrack Mountains on the east and the Sierra Nevada on the west. The Mono-Inyo Craters volcanic chain forms a north-trending zone of volcanic vents extending from the west moat of the Long Valley caldera to Mono Lake. The Hartley Springs fault transects the southern Mono Craters-Inyo Domes area between the western part of the Long Valley caldera and June Lake. Stratigraphic data suggest that a series of strong earthquakes occurred during the North Mono-Inyo eruption sequence of ~1350 A.D. The spatial and temporal proximity between Hartley Springs Fault motion and the North Mono-Inyo eruption sequence suggests a possible relation between seismic events and eruptions. We investigate the interactions between slip along the Hartley Springs fault and dike intrusion beneath the Mono-Inyo craters using a three-dimensional finite element model of the Mono Basin. We employ a realistic representation of the Basin that includes topography, vertical and lateral heterogeneities of the crust, contact relations between fault planes, and a physical model of the pressure required to propagate the dike. We estimate (a) the distribution of Coulomb stress changes to study the influence of dike intrusion on Hartley Springs fault, and (b) the local stress and volumetric dilatation changes to understand how fault slip may influence the propagation of a dike towards the surface.

  18. Mechanisms of Complete Turbulence Suppression in Turbidity Currents Driven by Mono-Disperse and Bi-Disperse Suspensions of Sediment

    Directory of Open Access Journals (Sweden)

    Mrugesh S. Shringarpure

    2014-09-01

    appears to have a logarithmic dependence on Reτ (Cantero et al. 2012. DNS of turbidity currents driven by bi-disperse suspension of sediments is also carried out and compared with the results of mono-disperse suspensions.

  19. Experimental damping assessment of a full scale offshore mono bucket foundation

    DEFF Research Database (Denmark)

    Gres, Szymon; Fejerskov, Morten; Ibsen, Lars Bo

    2016-01-01

    This paper quantifies the system damping of a offshore meteorological mast supported by a Mono Bucket foundation based on a long-term experimental campaign. The structure is located at Dogger Bank west, North Sea, and equipped with a measurement system monitoring acceleration, strain, inclination...

  20. 21 CFR 172.856 - Propylene glycol mono- and diesters of fats and fatty acids.

    Science.gov (United States)

    2010-04-01

    ... fatty acids. 172.856 Section 172.856 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... diesters of fats and fatty acids. Propylene glycol mono- and diesters of fats and fatty acids may be safely... and/or fatty acids in compliance with § 172.860 and/or oleic acid derived from tall oil fatty acids in...

  1. Elimination of Cu (II) and Zn (II) ions in mono-element and the bi ...

    African Journals Online (AJOL)

    Elimination of Cu (II) and Zn (II) ions in mono-element and the bi-element aqueous solutions by adsorption on natural clay of Bikougou (Gabon) ... The modeling of the experimental results is better achieved by application of. Freundlich adsorption isotherm and Langmuir adsorption isotherm concerning the adsorption of Cu ...

  2. Emotions in freely varying and mono-pitched vowels, acoustic and EGG analyses.

    Science.gov (United States)

    Waaramaa, Teija; Palo, Pertti; Kankare, Elina

    2015-12-01

    Vocal emotions are expressed either by speech or singing. The difference is that in singing the pitch is predetermined while in speech it may vary freely. It was of interest to study whether there were voice quality differences between freely varying and mono-pitched vowels expressed by professional actors. Given their profession, actors have to be able to express emotions both by speech and singing. Electroglottogram and acoustic analyses of emotional utterances embedded in expressions of freely varying vowels [a:], [i:], [u:] (96 samples) and mono-pitched protracted vowels (96 samples) were studied. Contact quotient (CQEGG) was calculated using 35%, 55%, and 80% threshold levels. Three different threshold levels were used in order to evaluate their effects on emotions. Genders were studied separately. The results suggested significant gender differences for CQEGG 80% threshold level. SPL, CQEGG, and F4 were used to convey emotions, but to a lesser degree, when F0 was predetermined. Moreover, females showed fewer significant variations than males. Both genders used more hypofunctional phonation type in mono-pitched utterances than in the expressions with freely varying pitch. The present material warrants further study of the interplay between CQEGG threshold levels and formant frequencies, and listening tests to investigate the perceptual value of the mono-pitched vowels in the communication of emotions.

  3. Some transition metal complexes derived from mono- and di-ethynyl perfluorobenzenes

    NARCIS (Netherlands)

    Armitt, D.J.; Bruce, M.I.; Gaudio, M.; Zaitseva, N.N.; Skelton, B.W.; White, A.H.; Le Guennic, B.; Halet, J.-F.; Fox, M.A.; Roberts, R.L.; Hartl, F.; Low, P.J.

    2008-01-01

    Transition metal alkynyl complexes containing perfluoroaryl groups have been prepared directly from trimethylsilyl-protected mono- and di-ethynyl perfluoroarenes by simple desilylation/metallation reaction sequences. Reactions between Me3SiC CC6F5 and RuCl(dppe)Cp'[Cp' = Cp, Cp*] in the presence of

  4. Nuchal translucency measurements are highly correlated in both mono- and dichorionic twin pairs

    DEFF Research Database (Denmark)

    Wøjdemann, Karen R; Larsen, Severin Olesen; Shalmi, Anne-Cathrine

    2006-01-01

    OBJECTIVES: To establish the distribution of serological and ultrasound first-trimester Down syndrome markers in twins and identify correlations of significance for risk calculation. METHODS: Nuchal translucency (NT), PAPP-A and betahCG data were extracted from 181 twin pregnancies (31 mono- and ...

  5. IRIS Toxicological Review of Ethylene Glycol Mono Butyl Ether (Egbe) (Final Report)

    Science.gov (United States)

    EPA has finalized the Toxicological Review of Ethylene Glycol Mono Butyl Ether: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.

  6. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from ot...

  7. Conformational studies on pertrimethylsilyl derivatives of some mono- and disaccharides by 220 MHz PMR spectroscopy

    NARCIS (Netherlands)

    Vliegenthart, J.F.G.; Streefkerk, D.G.; Bie, M.J.A. de

    1973-01-01

    The complete interpretation of 220 MHz PMR spectra and the accurate chemical shifts and coupling constants, obtained after computer simulation of the spectra, of a number of TMS-mono and -disaccharides are given. By means of an adapted Karplus equation the conformation of the derivatives has been

  8. Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells

    NARCIS (Netherlands)

    van Aken, B. E.; Jansen, J.; van Deventer, S. J.; Reitsma, P. H.

    2000-01-01

    Hyperhomocysteinemia is a risk factor for atherosclerosis and thrombosis. The aim of this study was to analyze if exposure of monocytic cells to increased levels of homocysteine (HCY) induces the accumulation of inflammatory mediators. Interleukin (IL)-6 production by monocytic cell line Mono Mac 6

  9. The Effects of Operational Parameters on a Mono-wire Cutting System: Efficiency in Marble Processing

    Science.gov (United States)

    Yilmazkaya, Emre; Ozcelik, Yilmaz

    2016-02-01

    Mono-wire block cutting machines that cut with a diamond wire can be used for squaring natural stone blocks and the slab-cutting process. The efficient use of these machines reduces operating costs by ensuring less diamond wire wear and longer wire life at high speeds. The high investment costs of these machines will lead to their efficient use and reduce production costs by increasing plant efficiency. Therefore, there is a need to investigate the cutting performance parameters of mono-wire cutting machines in terms of rock properties and operating parameters. This study aims to investigate the effects of the wire rotational speed (peripheral speed) and wire descending speed (cutting speed), which are the operating parameters of a mono-wire cutting machine, on unit wear and unit energy, which are the performance parameters in mono-wire cutting. By using the obtained results, cuttability charts for each natural stone were created on the basis of unit wear and unit energy values, cutting optimizations were performed, and the relationships between some physical and mechanical properties of rocks and the optimum cutting parameters obtained as a result of the optimization were investigated.

  10. Production of pulse in mono-cropped rice system in the coastal region of Eastern India

    International Nuclear Information System (INIS)

    Khan, A.R.; Nanda, P.; Chandra, Dinesh; Ghorai, A.K.; Behera, M.S.

    2001-04-01

    This experiment was undertaken with an objective to increase the yield of black-gram leguminous pulse crop through optimal doses of phosphatic fertilizer with supplemental irrigation in mono-cropped rice-fallow regions of India. Irrigation and phosphorus fertilizer application were introduced for enhancing productivity of black-gram to provide better returns to available water resources

  11. Retrograde axoplasmic flow of serotonin in central mono-aminergic neurons

    International Nuclear Information System (INIS)

    Leger, Lucienne; Pujol, J.-F.; Bobillier, Pierre; Jouvet, Michel

    1977-01-01

    Following an injection of 3 H-5 HT in the neostriatum of the Rat, the tracer is transported by axoplasmic retrograde flow to the cell groups containing mono-aminergic neurons which are known or thought to have afferences to this structure: substantia nigra, dopaminergic group A8 and n. raphe dorsalis [fr

  12. Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    Pharmaceutical products containing proteins cause problems in testing for endotoxin and pyrogens. Many proteins interfere with the LAL test and the proteins are immunogenic in rabbits. The monocytic cell line Mono Mac 6 is an alternative assay for detection of endotoxin and other pyrogens....

  13. Tri-block copolymers with mono-disperse crystallizable diamide segments: synthesis, analysis and rheological properties

    NARCIS (Netherlands)

    Araichimani, A.; Gaymans, R.J.

    2008-01-01

    Tri-block copolymers with polyether mid-segments and mono-disperse amide end segments were synthesized, analyzed and some properties studied. The end segment was an aromatic diamide (diaramide, TΦB). The polyether mid-segment was a difunctional poly(tetramethylene oxide) (PTMO, 1000 and 2900 g/mol).

  14. The nest predator assemblage for songbirds in Mono Lake basin riparian habitats

    Science.gov (United States)

    Quresh S. Latif; Sacha K. Heath; Grant Ballard

    2012-01-01

    Because nest predation strongly limits avian fitness, ornithologists identify nest predators to inform ecological research and conservation. During 2002–2008, we used both video-monitoring of natural nests and direct observations of predation to identify nest predators of open-cup nesting riparian songbirds along tributaries of Mono Lake, California. Video cameras at...

  15. Health Disparities and Relational Well-Being between Multi- and Mono-Ethnic Asian Americans

    Science.gov (United States)

    Zhang, Wei

    2013-01-01

    Focusing on Hawaii, a state with 21.3% of the population being multi-racial according to the 2010 U.S. Census, this study aims to examine the existence and nature of health disparities between mono- and multi-ethnic Asian Americans and the importance of Relational Well-Being in affecting the health of Asian Americans. A series of ordinary least…

  16. Ultrasonication of pyrogenic microorganisms improves the detection of pyrogens in the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    The monocytic cell line Mono Mac 6 is sensitive to pyrogens. When exposed to pyrogens secretion of interleukin-6 is induced. However, some eukaryotic pyrogenic microorganisms are not detectable. The aim of this study is to introduce a pretreatment of samples to expand the detection range of the a...

  17. Water miscible mono alcohols' effect on the proteolytic performance of Bacillus clausii serine alkaline protease.

    Science.gov (United States)

    Duman, Yonca Avci; Kazan, Dilek; Denizci, Aziz Akin; Erarslan, Altan

    2014-01-01

    In this study, our investigations showed that the increasing concentrations of all examined mono alcohols caused a decrease in the Vm, kcat and kcat/Km values of Bacillus clausii GMBE 42 serine alkaline protease for casein hydrolysis. However, the Km value of the enzyme remained almost the same, which was an indicator of non-competitive inhibition. Whereas inhibition by methanol was partial non-competitive, inhibition by the rest of the alcohols tested was simple non-competitive. The inhibition constants (KI) were in the range of 1.32-3.10 M, and the order of the inhibitory effect was 1-propanol>2-propanol>methanol>ethanol. The ΔG(≠) and ΔG(≠)E-T values of the enzyme increased at increasing concentrations of all alcohols examined, but the ΔG(≠)ES value of the enzyme remained almost the same. The constant Km and ΔG(≠)ES values in the presence and absence of mono alcohols indicated the existence of different binding sites for mono alcohols and casein on enzyme the molecule. The kcat of the enzyme decreased linearly by increasing log P and decreasing dielectric constant (D) values, but the ΔG(≠) and ΔG(≠)E-T values of the enzyme increased by increasing log P and decreasing D values of the reaction medium containing mono alcohols.

  18. On the positron-trapping states of metal mono-vacancies

    International Nuclear Information System (INIS)

    Sankar, S.; Iyakutti, K.

    1987-07-01

    A model calculation based on the static dielectric screening theory has been performed to estimate the probable number of positron-trapping levels in metal mono-vacancies and it is shown that there cannot be more than one. (author). 8 refs, 1 tab

  19. Maillard reaction products of rice protein hydrolysates with mono-, oligo- and polysaccharides

    Science.gov (United States)

    Rice protein, a byproduct of rice syrup production, is abundant but, its lack of functionality prevents its wide use as a food ingredient. Maillard reaction products of (MRPs) hydrolysates from the limited hydrolysis of rice protein (LHRP) and various mono-, oligo- and polysaccharides were evaluat...

  20. Mitochondrial membranes with mono- and divalent salt: Changes induced by salt ions on structure and dynamics

    NARCIS (Netherlands)

    Pöyry, S.; Róg, T.; Karttunen, M.E.J.; Vattulainen, I.

    2009-01-01

    We employ atomistic simulations to consider how mono- (NaCl) and divalent (CaCl2) salt affects properties of inner and outer membranes of mitochondria. We find that the influence of salt on structural properties is rather minute, only weakly affecting lipid packing, conformational ordering, and

  1. High-resolution aeromagnetic survey of the Mono Basin-Long Valley Caldera region, California

    Science.gov (United States)

    Ponce, D. A.; Mangan, M.; McPhee, D.

    2013-12-01

    A new high-resolution aeromagnetic survey of the Mono Basin-Long Valley Caldera region greatly enhances previous magnetic interpretations that were based on older, low-resolution, and regional aeromagnetic data sets and provides new insights into volcano-tectonic processes. The surveyed area covers a 8,750 km2 NNW-trending swath situated between the Sierra Nevada to the west and the Basin and Range Province to the east. The surveyed area includes the volcanic centers of Mono Lake, Mono-Inyo Craters, Mammoth Mountain, Devils Postpile, and Long Valley Caldera. The NW-trending eastern Sierra frontal fault zone crosses through the study area, including the active Mono Lake, Silver Lake, Hartley Springs, Laurel Creek, and Hilton Creek faults. Over 6,000 line-kilometers of aeromagnetic data were collected at a constant terrain clearance of 150 m, a flight-line spacing of 400 m, and a tie-line spacing of 4 km. Data were collected via helicopter with an attached stinger housing a magnetic sensor using a Scintrex CS-3 cesium magnetometer. In the northern part of the survey area, data improve the magnetic resolution of the individual domes and coulees along Mono Craters and a circular shaped magnetic anomaly that coincides with a poorly defined ring fracture mapped by Kistler (1966). Here, aeromagnetic data combined with other geophysical data suggests that Mono Craters may have preferentially followed a pre-existing plutonic basement feature that may have controlled the sickle shape of the volcanic chain. In the northeastern part of the survey, aeromagnetic data reveal a linear magnetic anomaly that correlates with and extends a mapped fault. In the southern part of the survey, in the Sierra Nevada block just south of Long Valley Caldera, aeromagnetic anomalies correlate with NNW-trending Sierran frontal faults rather than to linear NNE-trends observed in recent seismicity over the last 30 years. These data provide an important framework for the further analysis of the

  2. Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru.

    Directory of Open Access Journals (Sweden)

    Leonela Villegas

    Full Text Available Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes.A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Löwenstein-Jensen (LJ media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment.Of 1292 patients enrolled, 1039 (80% were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8% patients and rifampicin mono-resistance was present in 24 (2% patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR = 2.10; 95% confidence interval (CI: 1.1-4.1, and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95%CI: 1.9-47.8. Isoniazid mono-resistant patients had a higher risk of poor treatment outcomes including treatment failure (2/85, 2%, p-value<0.01 and death (4/85, 5%, p<0.02. Rifampicin mono-resistant patients had a higher risk of death (2/24, 8%, p<0.01.A high prevalence of isoniazid and rifampicin mono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes.

  3. Relación del estrés oxidativo y la pérdida de peso obtenida en pacientes obesos mórbidos mediante cirugía bariátrica con la técnica del cruce duodenal

    OpenAIRE

    Leonardo De Tursi Ríspoli; Antonio Vázquez Tarragón; Antonio Vázquez Prado; Guillermo Sáez Tormo; Ali Ismail Mahmoud; Marcos Bruna Esteban; Claudia Mulas Fernandez; Verónica Gumbau Puchol

    2013-01-01

    Introducción: El estrés oxidativo, presente de forma evidente en los obesos mórbidos, es un indicador del estado inflamatorio crónico que representa la obesidad y posible nexo de unión con sus comorbilidades, algunas de las cuales son un importante factor de riesgo para el desarrollo de enfermedades cardiovasculares, por lo que la atenuación de su intensidad se ha convertido en un objetivo terapéutico. Material y método: Hemos intervenido de forma consecutiva, mediante la técnica quirúrgica d...

  4. O efeito em curto prazo do bypass gástrico sobre pacientes obesos diabéticos Short-term effect of gastric bypass in obese diabetic patients

    Directory of Open Access Journals (Sweden)

    Aluisio Stoll

    2013-02-01

    Full Text Available OBJETIVO: estudar o efeito do bypass gástrico sobre a glicemia e o uso de medicação antidiabética em pacientes obesos portadores de diabetes. MÉTODOS: estudo de coorte retrospectivo com 44 pacientes obesos portadores de DM2, provenientes de 469 pacientes submetidos ao bypass gástrico no período de dezembro de 2001 a março de 2009. Os desfechos primários avaliados foram: glicemia em jejum e a necessidade de medicação antidiabética. RESULTADOS: a população foi composta de dez (22,7% homens e 34 (77,3% mulheres, com média de idade de 45,3 (±8,23 anos e índice de massa corporal de 40,9 (±5,03 kg/m². O tempo médio de evolução do DM2 foi 63,6 (±60,9 meses. Dos 40 pacientes que utilizavam medicação para controle do DM2, 20 (50% tiveram sua medicação suspensa na alta hospitalar e 13 (32,5% até nove meses depois. Em uma paciente não foi possível avaliar o uso de medicação, sendo essa a única exclusão. A insulina foi suspensa nos dez (100% pacientes que a utilizavam, sendo seis (60% na alta hospitalar. Houve redução (POBJECTIVE: To study the effect of gastric bypass on blood glucose levels and the use of antidiabetic medication in obese patients with diabetes. METHODS: We carried out a retrospective cohort study with 44 obese patients with DM2, from 469 patients undergoing gastric bypass from December 2001 to March 2009. The primary endpoints evaluated were fasting glucose and the need for antidiabetic medication. RESULTS: The study population consisted of ten (22.7% men and 34 (77.3% women, with a mean age of 45.3 (±8.23 years and a body mass index of 40.9 (±5.03 kg/m². The average time to progression of DM2 was 63.6 (±60.9 months. Of the 40 patients who used medication to control type 2 diabetes, 20 (50% had their medication discontinued at discharge and 13 (32.5%, until nine months later. In one patient it was not possible to evaluate the use of medication, this being the only exception. Insulin was suspended in

  5. Relação entre intensidade de dor e capacidade funcional em indivíduos obesos com osteoartrite de joelho Relationship between pain intensity and functional capacity of obese individuals with knee osteoarthritis

    Directory of Open Access Journals (Sweden)

    KSS Vasconcelos

    2006-01-01

    Full Text Available CONTEXTUALIZAÇÃO: A osteoartrite (OA de joelho é uma doença crônica que acomete a cartilagem articular, provocando alterações ósseas, dor e rigidez à movimentação. A obesidade é um dos seus principais fatores de risco. As queixas de dificuldades funcionais são freqüentes, especialmente para a locomoção, que se torna mais lenta. Com os crescentes níveis de obesidade no Brasil, torna-se importante compreender como a OA de joelho afeta a capacidade funcional humana, a fim de se elaborar medidas de tratamento e prevenção. OBJETIVO: Analisar a influência da intensidade de dor, gravidade radiográfica, grau de obesidade e duração dos sintomas na capacidade funcional de indivíduos obesos com OA de joelho. MÉTODO: A intensidade de dor foi medida pelo questionário Western Ontario and McMaster Universities Index (WOMAC e durante os testes funcionais. A gravidade radiográfica foi analisada pela classificação Kellgren-Lawrence e o grau de obesidade pelo índice de massa corporal (IMC. Foram realizados quatro testes funcionais de velocidade: marcha usual e rápida, subir e descer escadas. RESULTADOS: A amostra foi constituída de 31 mulheres e 4 homens, com idade média de 51,65 ± 10,72 anos e IMC médio de 41,16 ± 8,37 kg/m². As atividades em escadas estavam associadas a níveis mais intensos de dor. Apenas a intensidade de dor apresentou correlações significativas com os resultados nos testes de velocidade. CONCLUSÃO: A intensidade de dor é um fator que influencia a realização de atividades funcionais em indivíduos obesos com OA de joelho, mas outros estudos são necessários para identificar os fatores determinantes de capacidade funcional nesta população.BACKGROUND: Knee osteoarthritis is a chronic disease that affects joint cartilage, causing bone structure alterations, pain and stiffness during movement. Obesity is one of its principal risk factors. Complaints about functional disability are frequent, especially

  6. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    Full Text Available FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo Modelo de Avaliação da Homeostase (HOMA-RI: com resistência insulínica (RI n = 39 e sem resistência insulínica (NRI n = 27, e foram submetidos a uma intervenção interdisciplinar ao longo de um ano. A espessura mediointimal da artéria carótida comum (EMIC, e o tecido adiposo visceral e subcutâneo foram determinados por ultrassonografia. A composição corporal, pressão arterial, índice HOMA-RI, perfil lipídico e as concentrações de adipocinas [leptina, adiponectina, e inibidor do ativador do plasminogênio-1 (PAI-1] foram analisados antes e após a terapia. RESULTADOS: Ambos os grupos apresentaram melhoras significativas na composição corporal, estado inflamatório (redução da concentração de leptina e PAI 1; aumento de adiponectina plasmática e redução da EMIC. Apenas o grupo NRI mostrou correlação positiva entre as alterações na gordura visceral (∆Visceral e mudanças na EMIC (∆ EMIC (r = 0,42, p BACKGROUND: The atherosclerotic process at the endothelial level begins in early ages and seems to be associated with obesity and its comorbidities as insulin resistance. OBJECTIVE: The aim of this study was to verify the influence of insulin resistance on inflammatory and subclinical markers of atherosclerosis in obese adolescents. METHODS: Sixty-six post-pubescent obese adolescents were divided in two groups according to homeostasis model assessment of insulin resistance (HOMA-IR measurement: with insulin resistance

  7. Resistencia a la insulina e historia familiar de diabetes en niños y adolescentes obesos con acantosis nigricans y sin ella Insulin resistance and family history of diabetes in obese children and with and without acanthosis nigricans

    Directory of Open Access Journals (Sweden)

    Pedro González Fernández

    2011-12-01

    Full Text Available Introducción: las complicaciones metabólicas más importantes para la morbilidad y mortalidad que se derivan de la obesidad tienen como común denominador la resistencia a la insulina. Objetivo: determinar la existencia de resistencia a la insulina e historia familiar de diabetes en un grupo de niños y adolescentes obesos con y sin acantosis nigricans. Métodos: se estudiaron 46 sujetos obesos con y sin acantosis nigricans (21 varones y 25 hembras, con edades entre 4 y 16 años, procedentes de la consulta de endocrinología del Hospital Pediátrico Docente "William Soler", en el período de noviembre de 2006 a febrero de 2007. Se les realizó, además de examen físico y anamnesis, prueba de tolerancia a la glucosa con determinación de glucemia e insulinemia en ayunas y a las 2 h. Se utilizó como criterio de resistencia a la insulina el índice HOMA. Resultados: la mayoría de los pacientes (36 sujetos presentaron resistencia a la insulina, independientemente de la presencia o no de acantosis nigricans, que no estuvo relacionada con el grado de obesidad ni con el pliegue tricipital de grasa, pero sí con la historia familiar de diabetes tipo 2. La presencia de acantosis nigricans estuvo relacionada con el grado de obesidad. Se encontró un 13 % de pacientes con criterios de prediabetes. Conclusiones: la obesidad y la historia familiar de diabetes tipo 2 en los niños y adolescentes se relacionan con la presencia de resistencia a la insulina, independientemente de la presencia de acantosis nigricans.Introduction: the more important metabolic complications for morbidity and mortality derived from obesity have in common the insulin resistance. Objective: to determine the insulin resistance and the family history of diabetes in a group of obese children and adolescents with and without acanthosis nigricans. Methods: forty six obese subjects with and without acanthosis nigricans (21 boys and 25 girls aged between 4 and 16, from the "William

  8. Dust Generation Resulting from Desiccation of Playa Systems: Studies on Mono and Owens Lakes, California

    Science.gov (United States)

    Gill, Thomas Edward

    1995-01-01

    Playas, evaporites, and aeolian sediments frequently are linked components within the Earth system. Anthropogenic water diversions from terminal lakes form playas that release fugitive dust. These actions, documented worldwide, simulate aeolian processes activated during palaeoclimatic pluvial/interpluvial transitions, and have significant environmental impacts. Pluvial lakes Russell and Owens in North America's Great Basin preceded historic Mono and Owens Lakes, now desiccated by water diversions into dust-generating, evaporite -encrusted playas. Geochemical and hydrologic cycles acting on the Owens (Dry) Lake playa form three distinct crust types each year. Although initial dust production results from deflation of surface efflorescences after the playa dries, most aerosols are created by saltation abrasion of salt/silt/clay crusts at crust/ sand sheet contacts. The warm-season, clastic "cemented" crust is slowest to degrade into dust. If the playa surface is stabilized by an unbroken, non-efflorescent crust, dust formation is discouraged. When Mono Lake's surFace elevation does not exceed 1951 meters (6400 feet), similar processes will also generate dust from its saline lower playa. Six factors--related to wind, topography, groundwater, and sediments--control dust formation at both playas. These factors were combined into a statistical model relating suspended dust concentrations to playa/lake morphometry. The model shows the extent and severity of Mono Lake dust storms expands significantly below the surface level 6376 feet (1943.5 meters). X-ray diffraction analysis of Mono Basin soils, playa sediments, and aerosols demonstrates geochemical cycling of materials through land, air and water during Mono Lake's 1982 low stand. Soils and clastic playa sediments contain silicate minerals and tephra. Saline groundwater deposited calcite, halite, thenardite, gaylussite, burkeite and glauberite onto the lower playa. Aerosols contained silicate minerals (especially

  9. Oxygen uptake of overweight and obese children at different stages of a progressive treadmill test. (Consumo de oxígeno de niños y niñas con sobrepeso y obesos en los diferentes estadios de una prueba progresiva en un tapiz rodante.

    Directory of Open Access Journals (Sweden)

    Colleen Ann Boyle

    2010-01-01

    Full Text Available AbstractIntroduction: Maximal oxygen uptake (VO2 max is associated with cardiovascular and metabolic risks but it is difficult to assess in obese children. The objective of this study was to develop an equation to estimate VO2 (mL/kg/min and to check the % of tests that were maximal according to recommended criteria. Methods: Stress tests were analyzed of 222 subjects (94 male and 128 female with a BMI above the 85 percentile for age and sex, and repeated 4 months later. Mean age was 9.4 + 1.1 years and weighed 52.4 + 13.3 kg. Body fat % (40.5 + 6.2 was determined by DXA (Hologic QDR 4500W. The protocol on the treadmill started with a warm up at 2.5 and 3 mph with a slope of 0% and 2%. The speed was kept at 3 mph for all the stages and the slope was increased 2% every 2 minutes. Statistical analysis (descriptive, t-test and ANOVAS 2x2x2 was done with SPSS 15.0. Results: Only 35% of the tests were maximal. The equation calculates was Y = 2.6x + 22.3 (x = protocol stage. Data pre and post treatment were not statistically different. Discussion: Increments in VO2 were consistent despite subject diversity (sex, % body fat, physical fitness, treatment. Conclusion: To be able to estimate VO2 at the different stages of the test without complex equipment or specialized staff, will facilitate the performance of stress tests on a daily basis.ResumenIntroducción: El consumo máximo de oxígeno (VO2 max está asociado con riesgos cardiovasculares y metabólicos pero resulta difícil valorarlo en niños y niñas obesos. El objetivo de este trabajo fue desarrollar una ecuación para estimar su VO2 (mL/kg/min y comprobar el porcentaje de pruebas máximas según los criterios recomendados. Métodos: Se analizaron las pruebas de esfuerzo de 222 sujetos (94 varones y 128 mujeres con un IMC superior al percentil 85 para su edad y sexo, y las repetidas a los 4 meses. Su edad era 9,4 + 1,1 años y pesaban 52,4 + 13,3 kg. El % de grasa corporal (40,5 + 6,2 se

  10. AL Amyloidosis

    Directory of Open Access Journals (Sweden)

    Desport Estelle

    2012-08-01

    Full Text Available Abstract Definition of the disease AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig light chains (LC (most commonly of lambda isotype usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multiple myeloma or other B-cell lymphoproliferative disorders is unusual. The key event in the development of AL amyloidosis is the change in the secondary or tertiary structure of an abnormal monoclonal LC, which results in instable conformation. This conformational change is responsible for abnormal folding of the LC, rich in β leaves, which assemble into monomers that stack together to form amyloid fibrils. Epidemiology AL amyloidosis is the most common type of systemic amyloidois in developed countries with an estimated incidence of 9 cases/million inhabitant/year. The average age of diagnosed patients is 65 years and less than 10% of patients are under 50. Clinical description The clinical presentation is protean, because of the wide number of tissues or organs that may be affected. The most common presenting symptoms are asthenia and dyspnoea, which are poorly specific and may account for delayed diagnosis. Renal manifestations are the most frequent, affecting two thirds of patients at presentation. They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients. Heart involvement, which is present at diagnosis in more than 50% of patients, leading to restrictive cardiopathy, is the most serious complication and engages prognosis. Diagnostic methods The diagnosis relies on pathological examination of an involved site showing Congo red-positive amyloid deposits, with typical apple-green birefringence under polarized light, that stain positive with an anti-LC antibody by immunohistochemistry and

  11. 1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    International Nuclear Information System (INIS)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported

  12. 1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, Thomas Richard [Univ. of California, Berkeley, CA (United States)

    1991-10-01

    A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  13. 1. Mono((8)annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono((8)annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono((8)annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  14. Fabrication and Application of Mono-sized Spherical Micro Particles by Pulsated Orifice Ejection Method

    Directory of Open Access Journals (Sweden)

    DONG Wei

    2018-02-01

    Full Text Available A novel technology called pulsated orifice ejection method(POEM and used for preparing mono-sized and high-precision spherical micro particles was introduced in this article. The working principle of the technique was illustrated and it was in two modes:low-melting point diaphragm mode and high-melting point rod mode, depending on the different melting points of materials. The particles prepared by POEM have the advantages of mono-sized, uniform and controllable particle size, high sphericity, and consistent thermal history. By introducing the application of particles prepared by this method, showing the huge application prospects of this technology in electronic packaging, bioengineering, micro-fabrication, rapid solidification analysis of metal droplets, additive manufacturing and so on.With the development of POEM, this technology is predicted to have wider prospects due to its unique characteristics.

  15. Rotavirus infection in children: mono-and combines forms, especially clinics and course

    Directory of Open Access Journals (Sweden)

    N. B. Denisyuk

    2012-01-01

    Full Text Available Analyzed 74 case histories of children under one year with rotavirus infection. The most commonly detected rotavirus gastroenteritis in the form of mono-and combined forms. Mono-infection in 78.3% of cases occurred in the moderate form with a leading syndrome in the form of gastroenteritis, severe dehydration proceeded with symptoms of varying severity. Mixed variants in 98.7% of cases are in the unfavorable premorbid background, in 42.8% of children were registered in the severe forms, and children younger than 6 months were erased within. The diagnosis of intestinal infection was confirmed by PCR, bacteriological and immunological methods.

  16. Photo-modulation of the spin Hall conductivity of mono-layer transition metal dichalcogenides

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, Parijat; Bellotti, Enrico [Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215 (United States)

    2016-05-23

    We report on a possible optical tuning of the spin Hall conductivity in mono-layer transition metal dichalcogenides. Light beams of frequencies much higher than the energy scale of the system (the off-resonant condition) do not excite electrons but rearrange the band structure. The rearrangement is quantitatively established using the Floquet formalism. For such a system of mono-layer transition metal dichalcogenides, the spin Hall conductivity (calculated with the Kubo expression in presence of disorder) exhibits a drop at higher frequencies and lower intensities. Finally, we compare the spin Hall conductivity of the higher spin-orbit coupled WSe{sub 2} to MoS{sub 2}; the spin Hall conductivity of WSe{sub 2} was found to be larger.

  17. Geochemistry of ikaite formation at Mono Lake, California: Implications for the origin of tufa mounds

    Science.gov (United States)

    Council, Todd C.; Bennett, Philip C.

    1993-11-01

    The mineral ikaite (CaCO3 ṡ 6H2O), not previously observed in lake environments, precipitates seasonally along the shore of Mono Lake, California, where Ca-HCO3 spring water mixes with cold Na-CO3 lake water. During the winter, cold water temperatures and high concentrations of PO43- and organic carbon inhibit calcite precipitation, allowing the metastable ikaite to form. During the spring warming, however, ikaite decomposes to form calcium carbonate and water, occasionally leaving pseudomorphs of the primary precipitate. The identification of modern ikaite suggests that both Pleistocene and Holocene tufas in the Mono basin originally precipitated as ikaite. This mineral may also form in other lake environments, but rapid recrystallization after warming destroys the physical, chemical, and isotopic evidence of formation, and alters the geochemical record.

  18. Radiocarbon constraints on fossil thinolite tufa formation in the Mono Basin, CA, USA

    Science.gov (United States)

    Leroy, S. L.; Zimmerman, S. R.; Hemming, S. R.; Stine, S.; Guilderson, T. P.

    2009-12-01

    Mono Lake is a terminal lake located at the western edge of the Great Basin, and is famous for its tufa towers. Thinolite, which is thought to be a CaCO3 pseudomorph of ikaite, is found around the Mono Basin in many fossil tufa towers, particularly at elevations above 2000 meters. The subaqueous parent mineral ikaite forms at low temperatures (34 kyr) to as young as 15.5 14C kyr BP. In general there is a consistent stratigraphic trend of ages within the mound, but the thinolite ages are anomalously young and one thinolite sample shows a large age reversal. The best estimate of the age of the precipitation of this tufa mound is given by the non-thinolite textures. More work is needed to determine the best sampling and sample preparation strategies in order to get a reliable age model for this mound.

  19. Designing real-time systems based on mono-master Profibus-DP networks

    OpenAIRE

    Monforte, Salvatore; Alves, Mário; Vasques, Francisco; Tovar, Eduardo

    2000-01-01

    Profibus networks are widely used as the communication infrastructure for supporting distributed computer-controlled applications. Most of the times, these applications impose strict real-time requirements. Profibus-DP has gradually become the preferred Profibus application profile. It is usually implemented as a mono-master Profibus network, and is optimised for speed and efficiency. The aim of this paper is to analyse the real-time behaviour of this class of Profibus networks...

  20. Heavy metals behaviour during mono-combustion and co-combustion of sewage sludge

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, M. Helena; Abelha, Pedro; Olieveira, J.F. Santos; Gulyurtlu, Ibrahim; Cabrita, Isabel [INETI-DEECA, Lisboa (Portugal)

    2005-03-01

    This paper presents the study of the combustion of granular dry sewage sludge performed on a pilot fluidized bed system. The results of mono-combustion of sludge and co-combustion with coal were compared with those of coal combustion for ash partitioning, the formation of gaseous pollutants and heavy metals behaviour. It was found that the mineral matter of sludge was essentially retained as bottom ashes. The production of fines ashes was small during the mono-combustion due to the tendency of coal to produce fine ashes which also contained unburned char. The degree of heavy metal volatilization was found to be slightly higher during co-combustion than in mono-combustion; however, most of them were retained in ashes and their emissions were found to be below the regulated levels. Hg was completely volatilized; however, during combustion trials involving coal it was captured by cyclone ashes at temperatures below 300 deg C. During sludge mono-combustion the retention of Hg in cyclone ashes containing low LOI was not enough to decrease emissions below the regulated levels; hence, it is necessary to install dedicated flue gas treatment for Hg removal. The leachability and ecotoxicity of sludge and ashes was compared with the new regulatory limits for landfill disposal in the EU. It was found that the release of organic matter and heavy metals found in the sludge was low from granular bed ashes; hence, except for sulphate release, bed ashes were converted into inert and non-ecotoxic materials. Ashes from test with limestone and cyclone ashes seemed to be more problematic because of pH effects and contamination with steel corrosion products. The recovery and reutilization of sludge bed ashes could, therefore, be possible, as long as the release of sulphate do not interfere with the process.

  1. Mono-implicit Runge Kutta schemes for singularly perturbed delay differential equations

    Science.gov (United States)

    Rihan, Fathalla A.; Al-Salti, Nasser S.

    2017-09-01

    In this paper, we adapt Mono-Implicit Runge-Kutta schemes for numerical approximations of singularly perturbed delay differential equations. The schemes are developed to reduce the computational cost of the fully implicit method which combine the accuracy of implicit method and efficient implementation. Numerical stability properties of the schemes are investigated. Numerical simulations are provided to show the effectiveness of the method for both stiff and non-stiff initial value problems.

  2. Constraining Dark Matter using Mono-X, Dijet, and Dilepton Final States with the ATLAS Detector

    CERN Document Server

    Tolley, Emma; The ATLAS collaboration

    2017-01-01

    Weakly-coupled TeV-scale particles may mediate interactions between dark matter (DM) and Standard Model (SM) particles. DM production at colliders may be evident in “mono-X” topologies, and mediator production in in dijet and dilepton events. The latest results obtained by the ATLAS experiment are presented and interpreted following the LHC DM WG guidelines, with particular focus on the complementarity between different collider searches as well as direct detection experiments.

  3. [Improvement of symptoms in mild hyperthyroidism with an extract of Lycopus europaeus (Thyreogutt® mono)].

    Science.gov (United States)

    Eiling, Rudolf; Wieland, Veronika; Niestroj, Michael

    2013-02-01

    Extracts of Lycopus europaeus are used clinically for the control of vegetative and irritative symptoms in mild hyperthyroidism. This study assessed the effects and safety of an extract of Lycopus europaeus (Thyreogutt® mono tablets or drops) in a general practice setting. The study was conducted as an open post-marketing surveillance study consisting of three cohorts, i.e. a prolective assessment in patients receiving Thyreogutt® mono for 4 weeks, a retrolective documentation of data from patients who had received at least one course (4 weeks) of Thyreogutt® mono therapy during the previous 2 years, and a control cohort receiving no drug treatment. Assessments comprised symptoms of mild hyperthyroidism, laboratory tests of thyroid function and adverse events surveillance. Response was defined as normal thyroid hormone values at the end of therapy or a reduction of at least 20% in the number of symptoms after treatment. Responder rates were calculated. Four hundred and three patients with mild symptomatic hyperthyroidism were observed. The prolective assessment included 146 patients, the retrolective assessment 171 patients, and the control cohort 86 untreated patients. The responder rate was 72.6% in the prolective assessment and 96.5% in the retrolective assessment whereas the responder rate in the untreated control cohort amounted to 41.2%. No adverse events were reported. The extract of Lycopus europaeus was well tolerated and associated with a statistically significant and clinically relevant improvement of the symptoms in mild hyperthyroidism. The improvement was markedly better in both Thyreogutt® mono cohorts than in the control cohort.

  4. Mono-Type TFT Logic Architectures for Low Power Systems on Panel Applications

    OpenAIRE

    Yang, Yifan; Lee, Sungsik; Holburn, David Michael; Nathan, Arokia

    2016-01-01

    This paper introduces novel 7-T pseudo-CMOS for enhancement mode and 6-T pseudo-CMOS for depletion mode inverter circuit architectures. The designs are built around mono-type of TFTs and consume less power consumption than existing 4-T pseudo-CMOS circuits. In addition, they provide steep transfer curves, along with embedded control for compensation of device parameter variations. Analysis of the transient behavior for the various circuit architectures is presented, providing quantitative ins...

  5. Screening for nonalcoholic steatohepatitis by using cytokeratin 18 and transient elastography in HIV mono-infection.

    Directory of Open Access Journals (Sweden)

    Amine Benmassaoud

    Full Text Available HIV-infected individuals are at high risk of developing nonalcoholic steatohepatitis (NASH, a leading cause of end-stage liver disease in Western countries. Nonetheless, due to the invasiveness of liver biopsy, NASH remains poorly understood in HIV mono-infection. We aimed to characterize the prevalence and predictors of NASH in unselected HIV mono-infected patients by means of non-invasive diagnostic tools.HIV-infected adults without significant alcohol intake or co-infection with hepatitis B or C underwent a routine screening program employing transient elastography (TE with controlled attenuation parameter (CAP and the serum biomarker cytokeratin-18 (CK-18. NASH was diagnosed non-invasively as the coexistence of fatty liver (CAP ≥248 dB/m and CK-18 >246 U/L. Identified cases of NASH were offered a diagnostic liver biopsy. Predictors of NASH were determined by multivariate logistic regression analysis.202 consecutive HIV mono-infected patients were included. NASH was non-invasively diagnosed in 23 cases (11.4%. Among them, 17 underwent a liver biopsy, and histology confirmed NASH in all cases. The prevalence of NASH was higher in patients with hypertriglyceridemia (17.1%, insulin resistance defined by homeostasis model for assessment of insulin resistance (HOMA-IR (25%, those with detectable HIV viral load (42.9% and those with elevated ALT (53.6%. After adjustment, higher HOMA-IR (adjusted odds ratio [aOR] = 1.20, 95% CI 1.01-1.43; p = 0.03 and ALT (aOR = 2.39, 95% CI 1.50-3.79; p<0.001 were independent predictors of NASH.NASH, diagnosed by a non-invasive diagnostic approach employing CK-18 and TE with CAP, is common in unselected HIV mono-infected individuals, particularly in the presence of insulin resistance and elevated ALT.

  6. SIMAC - A phosphoproteomic strategy for the rapid separation of mono-phosphorylated from multiply phosphorylated peptides

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Robinson, Phillip J

    2008-01-01

    spectrometric analysis, such as immobilized metal affinity chromatography or titanium dioxide the coverage of the phosphoproteome of a given sample is limited. Here we report a simple and rapid strategy - SIMAC - for sequential separation of mono-phosphorylated peptides and multiply phosphorylated peptides from...... and an optimized titanium dioxide chromatographic method. More than double the total number of identified phosphorylation sites was obtained with SIMAC, primarily from a three-fold increase in recovery of multiply phosphorylated peptides....

  7. Leptonic mono-top from single stop production at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Duan, Guang Hua [CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences,Beijing 100190 (China); Hikasa, Ken-ichi [Department of Physics, Tohoku University,Sendai 980-8578 (Japan); Wu, Lei [Department of Physics and Institute of Theoretical Physics, Nanjing Normal University,Nanjing, Jiangsu 210023 (China); ARC Centre of Excellence for Particle Physics at the Terascale,School of Physics, The University of Sydney,NSW 2006 (Australia); Yang, Jin Min [CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences,Beijing 100190 (China); Department of Physics, Tohoku University,Sendai 980-8578 (Japan); Zhang, Mengchao [Center for Theoretical Physics and Universe, Institute for Basic Science (IBS),Daejeon 34051 (Korea, Republic of)

    2017-03-16

    Top squark (stop) can be produced via QCD interaction but also the electroweak interaction at the LHC. In this paper, we investigate the observability of the associated production of stop and chargino, pp→t̃{sub 1}χ̃{sub 1}{sup −}, in compressed electroweakino scenarios at 14 TeV LHC. Due to small mass splitting between the lightest neutralino (χ̃{sub 1}{sup 0}) and chargino (χ̃{sub 1}{sup −}), the single stop production can give the mono-top signature through the stop decay t̃{sub 1}→tχ̃{sub 1}{sup 0}. We analyze the leptonic mono-top channel of the single stop production and propose a lab-frame observable cos θ{sub bℓ} to reduce the SM backgrounds. We find that such leptonic mono-top events from the single stop production can be probed at 2σ level at the HL-LHC if m{sub t̃{sub 1}}<760 GeV and m{sub χ̃{sub 1{sup 0}}}<150 GeV. Given a discovery of the stop and a measurement of the single stop production cross section, the stop mixing angle can also be determined from the single stop production at the HL-LHC.

  8. Intra-articular osteoid osteoma as a differential diagnosis of diffuse mono-articular joint pain.

    Science.gov (United States)

    Rolvien, Tim; Zustin, Jozef; Mussawy, Haider; Schmidt, Tobias; Pogoda, Pia; Ueblacker, Peter

    2016-11-04

    The aim of this retrospective study was to investigate the frequency of intra-articular osteoid osteoma (iaOO) in a large study cohort and to demonstrate its clinical relevance as an important differential diagnosis of non-specific mono-articular joint pain. We searched the registry for bone tumours of the University Medical Centre Hamburg-Eppendorf for osteoid osteomas in the last 42 years. Herein, we present three selected iaOO which were detected in the three major weight-bearing joints. Computed tomography (CT) or magnetic resonance imaging (MRI) scans were performed for initial diagnosis. Out of a total of 367 osteoid osteomas, 19 (5.2 %) tumours were localized intra-articularly. In all three presented tumours, a history of severe mono-articular pain was reported; however, the mean time to correct diagnosis was delayed to 20.7 months. Clearly, the nidus seen in CT and MRI images in combination with inconsistent salicylate-responsive nocturnal pain led to the diagnosis of iaOO. Rarely, osteoid osteoma can occur in an intra-articular location. In cases of diffuse mono-articular pain, iaOO should be considered both in large and smaller joints to avoid delays in diagnosis and therapy of this benign bone tumour.

  9. New thiol-responsive mono-cleavable block copolymer micelles labeled with single disulfides.

    Science.gov (United States)

    Sourkohi, Behnoush Khorsand; Schmidt, Rolf; Oh, Jung Kwon

    2011-10-18

    Thiol-responsive symmetric triblock copolymers having single disulfide linkages in the middle blocks (called mono-cleavable block copolymers, ss-ABP(2)) were synthesized by atom transfer radical polymerization in the presence of a disulfide-labeled difunctional Br-initiator. These brush-like triblock copolymers consist of a hydrophobic polyacrylate block having pendent oligo(propylene oxide) and a hydrophilic polymethacrylate block having pendent oligo(ethylene oxide). Gel permeation chromatography and (1)H NMR results confirmed the synthesis of well-defined mono-cleavable block copolymers and revealed that polymerizations were well controlled. Because of amphiphilic nature, these copolymers self-assembled to form colloidally stable micelles above critical micellar concentration of 0.032 mg · mL(-1). In response to reductive reactions, disulfides in thiol-responsive micelles were cleaved. Atomic force microscopy and dynamic light scattering analysis suggested that the cleavage of disulfides caused dissociation of micelles to smaller-sized assembled structures in water. Moreover, in a biomedical perspective, the mono-cleavable block copolymer micelles are not cytotoxic and thus biocompatible. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Unique Intramolecular Electronic Communications in Mono-ferrocenylpyrimidine Derivatives: Correlation between Redox Properties and Structural Nature

    International Nuclear Information System (INIS)

    Xiang, Debo; Noel, Jerome; Shao, Huibo; Dupas, Georges; Merbouh, Nabyl; Yu, Hua-Zhong

    2015-01-01

    Highlights: • Unique intramolecular electronic communications (electron withdrawing and π-bond delocalization effects) exist in the mono-ferrocenylpyrimidine derivatives. • The redox potential shift correlates the pyrimidine ring torsion angle with the extent of electron delocalization. • The correlation between redox properties and structural nature in mono-ferrocenylpyrimidine derivatives is evident. - Abstract: The correlation between redox properties and structural nature in a complete set of mono-ferrocenylpyrimidine derivatives (2-ferrocenylpyrimidine, 2-FcPy; 4-ferrocenylpyrimidine, 4-FcPy; 5-ferrocenylpyrimidine, 5-FcPy) was evaluated by investigating the intramolecular electronic communications. Both conventional electrochemical measurements in organic solvents and thin-film voltammetric studies of these compounds were carried out. It was discovered that their formal potentials are significantly different from each other, and shift negatively in the order of 4-FcPy > 5-FcPy > 2-FcPy. This result suggests that the intramolecular electronic communication is dictated by the delocalization effect of the π-bonding systems in 2-FcPy, and that the electron-withdrawing effect of the nitrogen atoms in the pyrimidine ring plays the key role in 4-FcPy and 5-FcPy. The single crystal X-ray structure analyis and Density Functional Theory (DFT) calculation provided additional evidence (e.g., different torsion angles between the cyclopentadienyl and pyrimidine rings) to support the observed correlation between the redox properties and structural nature

  11. Anaerobic mono-digestion of lucerne, grass and forbs – Influence of species and cutting frequency

    DEFF Research Database (Denmark)

    Wahid, Radziah; Feng, Lu; Cong, Wenfeng

    2018-01-01

    but it was not possible to ascertain whether this was due to organic overload alone or if high ammonia levels during Lu-4 digestion were contributing to the reduced performance. It was found that four cuts per year was suitable for a lab-scale mono-digestion system as the substrate was less fibrous and has lower dry......In the present study, biogas potentials of multispecies swards including grass, lucerne, caraway, ribwort plantain and chicory from two- and four-cut regimes (Mix-2 and Mix-4) for mono-digestion applying batch and continuous modes under lab-scale conditions were investigated. The gas yields...... confirmed with continuous experiments, during which the reactor digesting Mix-4 was stable throughout the experiment with low ammonia and volatile fatty acid (VFA) concentration. Meanwhile, mono-digestion of Lu-4 led to elevated VFA levels, even at a comparatively low organic loading rate of 1.76 g L−1 d−1...

  12. Assessment of genetic diversity and variation of acer mono max seedlings after spaceflight

    International Nuclear Information System (INIS)

    Long, C.; Li, Y.; Zhang, Y.; Yang, M.

    2015-01-01

    Genetic diversity and variation of Acer Mono Maxim seedlings sampled from space-mutated (sm) populations were compared to seedlings from parallel control (ck) ones using molecular markers. RAMP analysis showed that the percentage of polymorphic band, Shannon diversity index and Nei gene diversity index of the space-mutated populations were higher than those of the control ones, which indicated that genetic variation increased after spaceflight in populations of Acer Mono Maxim. By using un-weighted pair group method with arithmetic mean (UPGMA) method, three space-mutated repeats (populations) were clustered together, and control groups clustered separately, which further indicated that there was difference between the space-mutated ones and the control ones, which may be caused by space mutation. Further analysis of genomic inconsistency between the root and leaf samples from the same tree showed that a total variation rate of 6.3% and 1.7% were obtained in ten space-mutated individuals by using RAMP and SSR markers, respectively, however, the variation rate was zero in control ones. It provided that space mutation may be caused the individual variation of Acer Mono Maxim. (author)

  13. Simulation of gas hydrogen diffusion through partially water saturated mono-modal materials

    International Nuclear Information System (INIS)

    Boher, C.; Lorente, S.; Frizon, F.; Bart, F.

    2012-01-01

    Concerning the disposal of nuclear wastes, it is important to design concrete envelopes with pore networks that allow the diffusion of hydrogen towards the outside. This work documents the relationship between geo-polymers, which are materials with a quasi mono-modal pore network, and their gaseous diffusivity capacities. Using a mono-modal material allows studying a specific pore size contribution to gaseous diffusion. The pore network is characterized by mercury porosimetry. These experimental results are used as data in a model named MOHYCAN. The modeling work consists of creating a virtual pore network. Then, water layers are deposited in this network to simulate variable water saturation levels. Finally hydrogen is transported through the virtual network using a combination of ordinary diffusion and Knudsen diffusion. MOHYCAN calculates the hydrogen diffusion coefficient for water saturation degree from 0% to 100%. The impacts of the pore network arrangement or the pore network discretization have been studied. The results are, for a quasi mono-modal material: -) the diffusion coefficient is not sensitive to different virtual pore network arrangement; -) the diffusion coefficient values have a sharp drop at specific water saturation (this is due to the water saturation of the main and unique pore family); -) a 2 pores family based model is sufficient to represent the pore network. Theses observations will not be valid if we consider a material with a large pore size distribution, like cementitious materials

  14. Medición histológica micrométrica de capa muscular gástrica de pacientes obesos

    OpenAIRE

    Azabache C,Verónica

    2011-01-01

    Consideramos que la medición de la pared del estómago es importante en el desarrollo de la cirugía gástrica, no encontramos estudios histológicos previos en relación al grosor de ella. Considerando que la capa muscular ofrece la mayor resistencia durante los procedimientos de corte y sutura mecánica se plantea la medición histológica en micrones del músculo gástrico de estómagos sanos resecados por técnica bariátrica resectiva. Se realizó un protocolo para recolección de datos clínicos y de p...

  15. Microbial ecology of soda lakes: investigating sulfur and nitrogen cycling at Mono Lake, CA, USA

    Science.gov (United States)

    Fairbanks, D.; Phillips, A. A.; Wells, M.; Bao, R.; Fullerton, K. M.; Stamps, B. W.; Speth, D. R.; Johnson, H.; Sessions, A. L.

    2017-12-01

    Soda lakes represent unique ecosystems characterized by extremes of pH, salinity and distinct geochemical cycling. Despite these extreme conditions, soda lakes are important repositories of biological adaptation and have a highly functional microbial system. We investigated the biogeochemical cycling of sulfur and nitrogen compounds in Mono Lake, California, located east of the Sierra Nevada mountains. Mono lake is characterized by hyperalkaline, hypersaline and high sulfate concentrations and can enter prolonged periods of meromixis due to freshwater inflow. Typically, the microbial sulfur cycle is highly active in soda lakes with both oxidation and reduction of sulfur compounds. However, the biological sulfur cycle is connected to many other main elemental cycles such as carbon, nitrogen and metals. Here we investigated the interaction between sulfur and nitrogen cycling in Mono lake using a combination of molecular, isotopic, and geochemical observations to explore the links between microbial phylogenetic composition and functionality. Metagenomic and 16S rRNA gene amplicon sequencing were determined at two locations and five depths in May 2017. 16S rRNA gene amplicon sequencing analysis revealed organisms capable of both sulfur and nitrogen cycling. The relative abundance and distribution of functional genes (dsrA, soxAB, nifH, etc) were also determined. These genetic markers indicate the potential in situ relevance of specific carbon, nitrogen, and sulfur pathways in the water column prior to the transition to meromictic stratification. However, genes for sulfide oxidation, denitrification, and ammonification were present. Genome binning guided by the most abundant dsrA sequences, GC content, and abundance with depth identified a Thioalkalivibrio paradoxus bin containing genes capable of sulfur oxidation, denitrification, and nitrate reduction. The presence of a large number of sulfur and nitrogen cycling genes associated with Thioalkalivibrio paradoxus

  16. Single-step brazing process for mono-block joints and mechanical testing

    International Nuclear Information System (INIS)

    Casalegno, V.; Ferraris, M.; Salvo, M.; Rizzo, S.; Merola, M.

    2007-01-01

    Full text of publication follows: Plasma facing components act as actively cooled thermal shields to sustain thermal and particle loads during normal and transient operations in ITER (International Thermonuclear Experimental Reactor). The plasma-facing layer is referred to as 'armour', which is made of either carbon fibre reinforced carbon composite (CFC) or tungsten (W). CFC is the reference design solution for the lower part of the vertical target of the ITER divertor. The armour is joined onto an actively cooled substrate, the heat sink, made of precipitation hardened copper alloy CuCrZr through a thin pure copper interlayer to decrease, by plastic deformation, the joint interface stresses; in fact, the CFC to Cu joint is affected by the CTE mismatch between the ceramic and metallic material. A new method of joining CFC to copper and CFC/Cu to CuCrZr alloy was effectively developed for the flat-type configuration; the feasibility of this process also for mono-block geometry and the development of a procedure for testing mono-block-type mock-ups is described in this work. The mono-block configuration consists of copper alloy pipe shielded by CFC blocks. It is worth noting that in mono-block configuration, the large thermal expansion mismatch between CFC and copper alloy is more significant than for flat-tile configuration, due to curved interfaces. The joining technique foresees a single-step brazing process: the brazing of the three materials (CFC-Cu-CuCrZr) can be performed in a single heat treatment using the same Cu/Ge based braze. The composite surface was modified by solid state reaction with chromium with the purpose of increasing the wettability of CFC by the brazing alloy. The CFC substrate reacts with Cr which, forming a carbide layer, allows a large reduction of the contact angle; then, the brazing of CFC to pure copper and pure copper to CuCrZr by the same treatment is feasible. This process allows to obtain good joints using a non-active brazing

  17. Single-step brazing process for mono-block joints and mechanical testing

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, V.; Ferraris, M.; Salvo, M.; Rizzo, S. [Politecnico di Torino, Materials Science and Chemical Engineering Dept., Torino (Italy); Merola, M. [ITER International Team, llER Joint Work Site, Cadarache, 13 - St Paul Lez Durance (France)

    2007-07-01

    Full text of publication follows: Plasma facing components act as actively cooled thermal shields to sustain thermal and particle loads during normal and transient operations in ITER (International Thermonuclear Experimental Reactor). The plasma-facing layer is referred to as 'armour', which is made of either carbon fibre reinforced carbon composite (CFC) or tungsten (W). CFC is the reference design solution for the lower part of the vertical target of the ITER divertor. The armour is joined onto an actively cooled substrate, the heat sink, made of precipitation hardened copper alloy CuCrZr through a thin pure copper interlayer to decrease, by plastic deformation, the joint interface stresses; in fact, the CFC to Cu joint is affected by the CTE mismatch between the ceramic and metallic material. A new method of joining CFC to copper and CFC/Cu to CuCrZr alloy was effectively developed for the flat-type configuration; the feasibility of this process also for mono-block geometry and the development of a procedure for testing mono-block-type mock-ups is described in this work. The mono-block configuration consists of copper alloy pipe shielded by CFC blocks. It is worth noting that in mono-block configuration, the large thermal expansion mismatch between CFC and copper alloy is more significant than for flat-tile configuration, due to curved interfaces. The joining technique foresees a single-step brazing process: the brazing of the three materials (CFC-Cu-CuCrZr) can be performed in a single heat treatment using the same Cu/Ge based braze. The composite surface was modified by solid state reaction with chromium with the purpose of increasing the wettability of CFC by the brazing alloy. The CFC substrate reacts with Cr which, forming a carbide layer, allows a large reduction of the contact angle; then, the brazing of CFC to pure copper and pure copper to CuCrZr by the same treatment is feasible. This process allows to obtain good joints using a non

  18. Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI

    International Nuclear Information System (INIS)

    Winfield, Jessica M.; Collins, David J.; Morgan, Veronica A.; DeSouza, Nandita M.; Orton, Matthew R.; Ind, Thomas E.J.; Attygalle, Ayoma; Hazell, Steve

    2017-01-01

    Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinomas, 13 well/moderately differentiated, two poorly differentiated; three rare types) were imaged at 3 T using nine b-values (0 to 800 s mm -2 ). Mono-exponential, stretched exponential, kurtosis, statistical, and bi-exponential models were fitted. Model preference was assessed using Bayesian Information Criterion analysis. Differences in fitted parameters between tumour types/grades and correlation between fitted parameters were assessed using two-way analysis of variance and Pearson's linear correlation coefficient, respectively. Non-mono-exponential models were preferred by 83 % of tumours with bi-exponential and stretched exponential models preferred by the largest numbers of tumours. Apparent diffusion coefficient (ADC) and diffusion coefficients from non-mono-exponential models were significantly lower in poorly differentiated tumours than well/moderately differentiated tumours. α (stretched exponential), K (kurtosis), f and D* (bi-exponential) were significantly different between tumour types. Strong correlation was observed between ADC and diffusion coefficients from other models. Non-mono-exponential models were preferred to the mono-exponential model in DW-MRI data from cervical tumours. Parameters of non-mono-exponential models showed significant differences between types and grades of tumours. (orig.)

  19. Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI

    Energy Technology Data Exchange (ETDEWEB)

    Winfield, Jessica M.; Collins, David J.; Morgan, Veronica A.; DeSouza, Nandita M. [The Royal Marsden NHS Foundation Trust, MRI Unit, Sutton, Surrey (United Kingdom); The Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London (United Kingdom); Orton, Matthew R. [The Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London (United Kingdom); Ind, Thomas E.J. [The Royal Marsden NHS Foundation Trust, Gynaecology Unit, London (United Kingdom); Attygalle, Ayoma; Hazell, Steve [The Royal Marsden NHS Foundation Trust, Department of Histopathology, London (United Kingdom)

    2017-02-15

    Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinomas, 13 well/moderately differentiated, two poorly differentiated; three rare types) were imaged at 3 T using nine b-values (0 to 800 s mm{sup -2}). Mono-exponential, stretched exponential, kurtosis, statistical, and bi-exponential models were fitted. Model preference was assessed using Bayesian Information Criterion analysis. Differences in fitted parameters between tumour types/grades and correlation between fitted parameters were assessed using two-way analysis of variance and Pearson's linear correlation coefficient, respectively. Non-mono-exponential models were preferred by 83 % of tumours with bi-exponential and stretched exponential models preferred by the largest numbers of tumours. Apparent diffusion coefficient (ADC) and diffusion coefficients from non-mono-exponential models were significantly lower in poorly differentiated tumours than well/moderately differentiated tumours. α (stretched exponential), K (kurtosis), f and D* (bi-exponential) were significantly different between tumour types. Strong correlation was observed between ADC and diffusion coefficients from other models. Non-mono-exponential models were preferred to the mono-exponential model in DW-MRI data from cervical tumours. Parameters of non-mono-exponential models showed significant differences between types and grades of tumours. (orig.)

  20. Optimization of Controllable Factors in the Aluminum Silicon Eutectic Paste and Rear Silicon Nitride Mono-Passivation Layer of PERC Solar Cells

    Science.gov (United States)

    Park, Sungeun; Park, Hyomin; Kim, Dongseop; Yang, JungYup; Lee, Dongho; Kim, Young-Su; Kim, Hyun-Jong; Suh, Dongchul; Min, Byoung Koun; Kim, Kyung Nam; Park, Se Jin; Kim, Donghwan; Lee, Hae-Seok; Nam, Junggyu; Kang, Yoonmook

    2018-05-01

    Passivated emitter and rear contact (PERC) is a promising technology owing to high efficiency can be achieved with p-type wafer and their easily applicable to existing lines. In case of using p-type mono wafer, 0.5-1% efficiency increase is expected with PERC technologies compared to existing Al BSF solar cells, while for multi-wafer solar cells it is 0.5-0.8%. We addressed the optimization of PERC solar cells using the Al paste. The paste was prepared from the aluminum-silicon alloy with eutectic composition to avoid the formation of voids that degrade the open-circuit voltage. The glass frit of the paste was changed to improve adhesion. Scanning electron microscopy revealed voids and local back surface field between the aluminum electrode and silicon base. We confirmed the conditions on the SiNx passivation layer for achieving higher efficiency and better adhesion for long-term stability. The cell characteristics were compared across cells containing different pastes. PERC solar cells with the Al/Si eutectic paste exhibited the efficiency of 19.6%.

  1. Mono Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  2. Rabdomiólise em paciente obeso mórbido submetido a gastroplastia redutora e durante revascularização de membro superior em paciente pediátrico: relato de casos

    Directory of Open Access Journals (Sweden)

    Abrão Maria Angélica

    2006-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A rabdomiólise é uma síndrome que decorre da lesão ao músculo esquelético. Sua etiologia é ampla, trazendo um interesse particular, quando se manifesta como complicação intra ou pós-anestésica. O objetivo desse relato foi mostrar dois casos de rabdomiólise ocorridos no pós-operatório de intervenções cirúrgicas de longa duração, em pacientes com obesidade mórbida e lesão traumática, enfatizando a sua relação com a anestesia. RELATO DOS CASOS: O primeiro caso é de um paciente com 39 anos, obeso mórbido, IMC 62, submetido a gastroplastia redutora por laparotomia, sob anestesia geral. Apresentou, no pós-operatório, fraqueza muscular nos membros superiores e inferiores e alterações da sensibilidade. Evoluiu com dor muscular e urina avermelhada. O aumento dos níveis plasmáticos da enzima creatinocinase (CK confirmou o diagnóstico de rabdomiólise. Tratado com hidratação forçada e diurético, não evoluiu com insuficiência renal, porém teve alta com seqüela muscular e neurológica. O segundo caso apresenta uma criança de sete anos, vítima de acidente com porta de vidro, operada de urgência para revascularização do membro superior esquerdo. Apresentou mudança da coloração da urina, que se tornou avermelhada, durante a anestesia. Foram administrados bicarbonato de sódio e manitol por via venosa, com os objetivos de alcalinizar a urina e aumentar o débito urinário. Enviado ao CTI, onde foi confirmada a hipótese de rabdomiólise, pelo aumento da enzima CK e pela mioglobinúria. Obteve alta no 10º dia de internação, sem seqüelas. CONCLUSÕES: Os casos apresentados mostraram os fatores de risco da rabdomiólise e sua relação com a anestesia e a cirurgia. O diagnóstico precoce é importante, no sentido de um tratamento rápido e agressivo, a fim de se evitarem complicações mais graves.

  3. MRI gel dosimetry for verification of mono-isocentric junction doses in head and neck radiotherapy

    International Nuclear Information System (INIS)

    Back, S.A.J.; Jayasekera, P.M.; Lepage, M.; Baldock, C.; Menzies, N.; Back, P.

    2000-01-01

    Full text: The use of independent collimators in the abutment of two adjacent treatment volumes, as in head and neck radiation treatments, consists typically of positioning the collimator rotation axis (CRA) at the junction of the volumes, and offsetting each field by its half-field width. This has the effect of positioning one of the collimator jaws at the CRA for each field. However, misalignment of the jaws can lead to variations in dose uniformity in the junction region. We have used gel dosimetry to measure junction doses in three dimensions. PAG gel MRI was used to investigate junction dosimetry for a mono-isocentriic treatment of two orthogonal pairs of opposed (ant/post and lateral) 6 MV x-ray beams. PAG gels in an 11cm diameter cylindrical gel phantom were imaged using a Siemens Vision 1.5 T MRI. The exposures were made using a Philips SL 20 linear accelerator with independent jaws that were known to overlap at the isocentre for sequential abutting offset (within manufacturer's specifications for symmetric fields). X-Omat V films were exposed in mono-directional beams, and optically scanned for comparison. Measurements of off-axis ratios and of relative depth profiles using gel MRI and perpendicular film were in excellent agreement with each other. Measurements through the multi-directional junction at the isocentre are illustrated in the graph, for orthogonal planes centred at the isocentre of the neck phantom. They demonstrate a minimum dose of 75 % of that of the adjacent 'treatment' regions, which agrees closely with the results measured (72%) in the mono-directional case with film. We conclude that this measurement confirms that junction dosimetry at the isocentre measured with perpendicular film for a single direction is a good approximation to the situation in multiple directions. Copyright (2000) Australasian College of Physical Scientists and Engineers in Medicine

  4. Compartmentation of mono- and sesqui-terpene biosynthesis of the essential oil in poncirus trifoliata

    International Nuclear Information System (INIS)

    Heinrich, G.; Wegener, R.; Schultze, W.

    1980-01-01

    The fruit of Poncirus trifoliata shows glandular cells complexes in the exocarp, which produce a volatile oil rich in monoterpenes but poor in sesquiterpenes and oxigenated compounds. The juice vesicles of the endocarp possess similar cell complexes mainly containing sesquiterpenes and oxigenated compounds, whereas monoterpenes only occur in small amounts. By the use of combined gas chromatography-mass spectrometry 19 components of the rind oil and 15 compounds of the endocarp oil could be identified. As demonstrated by electron microscopy the terpenes most probably are synthesized predominantly, if not exclusively in plastids. As shown by gasradiochromatography radioactive precursors ( 14 Co 2 and 14 C-leucine) are incorporated into mono- and sesqui-terpenes to a different extent. This is due to two gland types producing essential oils of different composition with regard to their mono- and sesqui-terpene percentage. In fruit development the exocarp glands differentiate earlier than the endocarp glands do. The activity of exogenously applied 14 Co 2 first reaches the peripheral glands and later on appears in the interior glands. Depending upon the growth season, labelled leucine transported by the conducting tissues from lower plant parts leads to a high specific activity of the sesqui-terpenes and oxigenated compounds. It could be argued that in this instance the glands of the pulp are better provided with precursors than the exocarp glands. The successive maxima of essential oil production in both glandular complexes, and the changes in the concentration of individual oil constituents during the ontogeny of the fruit also contribute to different incorporation ratios of radioactive precursors into mono- and sesqui-terpenes. (author)

  5. Structure of the Mina Deflection in Mono Lake, CA: Inferences from Paleoseismology

    Science.gov (United States)

    Sangani, Radhika Chandrakant

    Walker Lane, a zone of transcurrent faulting along the Sierran range front, is dominated by NNW trending normal faults. Within the Walker Lane, the Mina Deflection is a region of structural anomaly, where a significant component of regional displacement and seismicity is transferred from NNW-trending faults to ENE-trending faults of the Excelsior-Coledale domain. Geographically, the western boundary of the Mina Deflection lies along the western margin of Mono Basin. This is kinematically implied by the distributed tensional and shear stress in the NNW- and ENE- trending faults of the region. Transfer of strain from the NNW-trending, right-lateral oblique slip faults to the ENE-trending, primarily left-lateral faults is poorly understood. The nature of this transfer is complicated by the presence of the young volcanics of Mono Lake at the stepover bend. I undertook detailed study of the sub-km scale geometry and kinematics of the stepover bend, and its relation to nearby recent magmatic fluid flow within the Mono Lake. Fault orientations, slip rates and ages of most recent events allow for understanding strain transfer between faulting and volcanism. The results suggest that strain is transferred from the outer arc to the inner arc of the stepover bend. Within the inner arc, the magmatism on Paoha Island seems to have arisen from a sill-like intrusion. Furthermore, strain transfer is accomplished through sets of faults and fissures that variously act as large-scale Reidel shears and tension gashes allowing the migration of magmatic fluids from depth.

  6. Resolving the age of Wilson Creek Formation tephras and the Mono Lake excursion using high-resolution SIMS dating of allanite and zircon rims

    Science.gov (United States)

    Vazquez, J. A.; Lidzbarski, M. I.

    2012-12-01

    Sediments of the Wilson Creek Formation surrounding Mono Lake preserve a high-resolution archive of glacial and pluvial responses along the eastern Sierra Nevada due to late Pleistocene climate change. An absolute chronology for the Wilson Creek stratigraphy is critical for correlating the paleoclimate record to other archives in the western U.S. and the North Atlantic region. However, multiple attempts to date the Wilson Creek stratigraphy using carbonates and interbedded rhyolitic tephras yield discordant 14C and 40Ar/39Ar results due to open-system effects, carbon reservoir uncertainties, as well as abundant xenocrysts entrained during eruption. Ion microprobe (SIMS) 238U-230Th dating of the final increments of crystallization recorded by allanite and zircon autocrysts from juvenile pyroclasts yields ages that effectively date eruption of key tephra beds and resolve age uncertainties about the Wilson Creek stratigraphy. To date the final several micrometers of crystal growth, individual allanite and zircon crystals were embedded in soft indium to allow sampling of unpolished rims. Isochron ages derived from rims on coexisting allanite and zircon (± glass) from hand-selected pumiceous pyroclasts delimit the timing of Wilson Creek sedimentation between Ashes 7 and 19 (numbering of Lajoie, 1968) to the interval between ca. 27 to ca. 62 ka. The interiors of individual allanite and zircon crystals sectioned in standard SIMS mounts yield model 238U-230Th ages that are mostly hydrologic responses in the Sierra Nevada and Mono Basin to climate change, with intervals of lake filling and glacial-snowpack melting that are in phase with peaks in spring insolation. Moreover, the results demonstrate that high-spatial resolution SIMS dating of accessory mineral rims is an alternative and promising approach for resolving the depositional ages of silicic tephras containing minerals that crystallized over protracted intervals or that are plagued by incorporation of xenocrysts

  7. Polyelectrolyte Properties in Mono and Multi-Valent Ionic Media: Brushes and Complex Coacervates

    Science.gov (United States)

    Farina, Robert M.

    Materials composed of polyelectrolytes have unique and interesting physical properties resulting primarily from their charged monomer segments. Polyelectrolytes, which exist in many different biological and industrial forms, have also been shown to be highly responsive to external environmental changes. Here, two specific polyelectrolyte systems, brushes and complex coacervates, are discussed in regards to how their properties can be tailored by adjusting the surrounding ionic environment with mono and multi-valent ions. End-tethered polyelectrolyte brushes, which constitute an interesting and substantial portion of polyelectrolyte applications, are well known for their ability to provide excellent lubrication and low friction when coated onto surfaces (e.g. articular cartilage and medical devices), as well as for their ability to stabilize colloidal particles in solution (e.g. paint and cosmetic materials). These properties have been extensively studied with brushes in pure mono-valent ionic media. However, polyelectrolyte brush interactions with multi-valent ions in solution are much less understood, although highly relevant considering mono and multi-valent counterions are present in most applications. Even at very low concentrations of multi-valent ions in solution, dramatic polyelectrolyte brush physical property changes can occur, resulting in collapsed chains which also adhere to one another via multi-valent bridging. Here, the strong polyelectrolyte poly(sodium styrene sulfonate) was studied using the Surface Forces Apparatus (SFA) and electrochemistry in order to investigate brush height and intermolecular interactions between two brushes as a function of multi-valent counterion population inside a brush. Complex coacervates are formed when polyanions and polycations are mixed together in proper conditions of an aqueous solution. This mixing results in a phase separation of a polymer-rich, coacervate phase composed of a chain network held together via

  8. Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome in mice

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper

    (NCFM) on the intestinal metabolome (jejunum, caecum, and colon) in mice by comparing NCFM mono-colonized (MC) mice with GF mice using liquid chromatography coupled to mass-spectrometry (LC-MS). The study adds to existing evidence that NCFM in vivo affects the bile acid signature of mice......-tocopherol acetate) in higher levels in the intestine of GF mice compared to MC mice, suggesting that NCFM either metabolizes the compound or indirectly affects the absorption by changing the metabolome in the intestine. The use of NCFM to increase the uptake of vitamin E supplements in humans and animals...

  9. Antagonistic Mono- and Bi-Articular Lower-Limb Muscle Activities’ Model Characterization at Different Speeds

    Directory of Open Access Journals (Sweden)

    Dzahir M.A.M

    2017-01-01

    Full Text Available Nowadays, medical rehabilitation system has become a requirement due to increment in national rehabilitation centres and medical hospitals. An assistive rehabilitation orthosis becomes essential and was used for rehabilitation therapy, condition monitoring, and physical strengthening. This study focused on the lower limb assistive rehabilitation orthosis development using pneumatic artificial muscle. To successfully control this orthosis system which consists of antagonistic mono- and biarticular muscle actuators, it is necessary to construct a reliable control algorithm. The suitable control scheme and strategy to manoeuvre this orthosis system similar to human musculoskeletal system have yet to be fully developed and established. Based on the review study, it is said that the co-contraction controls of anterior-posterior pneumatic muscles was able to improve the joint stiffness and stability of the orthosis as well as good manoeuvrability. Therefore, a characterization model of an antagonistic mono- and bi-articular muscles activities of human's lowerlimb during walking motion will be necessary. A healthy young male subject was used as test subject to obtain the sEMG muscle activities for antagonistic mono- and bi-articular muscles (i.e., Vastus Medialis-VM, Vastus Lateralis-VL, Rectus Femoris-RF, and Bicep Femoris-BF. The tests were carried out at different speeds of 2km/h, 3km/h, and 4km/h for one minute walking motion on a treadmill. Then, the patterns of the sEMG muscle activities were modelled and characterised using fifth order polynomial equation. Based on the results, it is shown that the anterior and posterior muscles were exhibited a muscle synergy in-between multiple anterior or posterior muscles and muscle co-contraction between anteriorposterior muscles in order to control the movements at the joints during walking motion. As conclusion, it is proven that the sEMG muscle activities of the antagonistic mono- and bi

  10. Hydrolysis of Zr(4) with formation of mono- and polynuclear hydroxocomplexes in solutions

    International Nuclear Information System (INIS)

    Davydov, Yu.P.; Zabrodskij, V.N.

    1987-01-01

    The state of Zr(4) has been studied in the wide range of H + -ions concentrations (10 -3 -3.0 mol/l) and in the wide range of Zr(4) concentrations (10 -13 -10 -12 mol/l) in the solution using a set of such physical-chemical methods as spectrophotometry, ion exchange, dialysis, centrifugation. The conditions of formation of hydrated cations, monochange, dialysis, centrifugation. The conditions of formation of hydrated cations, mono- and polynuclear hydrocomplexes, colloidal-size particles have been determined. The thermodynamic stability of ZrOH 3+ and Zr(OH) 2 2+ complexes has been determined by the ion exchange and spectrophotometry methods

  11. Forced vibration and wave propagation in mono-coupled periodic structures

    DEFF Research Database (Denmark)

    Ohlrich, Mogens

    1986-01-01

    This paper describes the wave propagation and vibration characteristics of mono-coupled structures which are of spatially periodic nature. The receptance approach to periodic structure theory is applied to study undamped periodic systems with composite structural elements; particular emphasis...... and a general `closed form' solution is found for the forced harmonic response at element junctions. This `junction-receptance' is used to determine-discrete junction mode shapes of a finite system. Finally, the forced response of a finite structure with an internal obstruction is derived as a natural extension...... of the determination of the junction-receptance. The influence of such a disorder is illustrated by a simple example...

  12. Degradation of a mono sulfonated azo dye by an integrated bio sorption and anaerobic system

    International Nuclear Information System (INIS)

    Goncalves, L. C.; Campos, R.; Pinheiro, H. M.; Lopes, A.; Ferra, M. I.

    2009-01-01

    A simulated textile effluent containing a mono sulphonated azo dye was fed to an anaerobic bioreactor in which a natural adsorbent, spent brewery grains (SBG), was incorporated. SABG is a by-product of the brewing industry and could act as adsorbent as well an electron shuttle (lignin fraction) in the dye degradation mechanism. Furthermore, it can also work as a conditioner for the anaerobic biomass. The influence of the dye (Acid Orange 7, AO7) concentration (60 and 150 mg/L) and the presence of SBG in the performance of upflow anaerobic sludge blanket reactor (UASB) was evaluated. (Author)

  13. A Tephra Database With an Intelligent Correlation System, Mono-Inyo Volcanic Chain, CA

    Science.gov (United States)

    Bursik, M.; Rogova, G.

    2004-12-01

    We are assembling a web-accessible, relational database of information on past eruptions of the Mono-Inyo volcanic chain, eastern California. The PostgreSQL database structure follows the North American Data Model and CordLink. The database allows us to extract the features diagnostic of particular pyroclastic layers, as well as lava domes and flows. The features include depth in the section, layer thickness and internal stratigraphy, mineral assemblage, major and trace element composition, tephra componentry and granulometry, and radiocarbon age. Our working hypotheses are that 1) the database will prove useful for unraveling the complex recent volcanic history of the Mono-Inyo chain 2) aided by the use of an intelligent correlation system integrated into the database system. The Mono-Inyo chain consists of domes, craters and flows that stretch for 50 km north-south, subparallel to the Sierran range front fault system. Almost all eruptions within the chain probably occurred less than 50,000 years ago. Because of the variety of magma and eruption types, and the migration of source regions in time and space, it is nontrivial to discern patterns of behaviour. We have explored the use of multiple artificial neural networks combined within the framework of the Dempster-Shafer theory of evidence to construct a hybrid information processing system as an aid in the correlation of Mono-Inyo pyroclastic layers. It is hoped that such a system could provide information useful to discerning eruptive patterns that would otherwise be difficult to sort and categorize. In a test case on tephra layers at known sites, the intelligent correlation system was able to categorize observations correctly 96% of the time. In a test case with layers at one unknown site, and using a pairwise comparison of the unknown site with the known sites, a one-to-one correlation between the unknown site and the known sites was found to sometimes be poor. Such a result could be used to aid a

  14. Degradation of a mono sulfonated azo dye by an integrated bio sorption and anaerobic system

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, L. C.; Campos, R.; Pinheiro, H. M.; Lopes, A.; Ferra, M. I.

    2009-07-01

    A simulated textile effluent containing a mono sulphonated azo dye was fed to an anaerobic bioreactor in which a natural adsorbent, spent brewery grains (SBG), was incorporated. SABG is a by-product of the brewing industry and could act as adsorbent as well an electron shuttle (lignin fraction) in the dye degradation mechanism. Furthermore, it can also work as a conditioner for the anaerobic biomass. The influence of the dye (Acid Orange 7, AO7) concentration (60 and 150 mg/L) and the presence of SBG in the performance of upflow anaerobic sludge blanket reactor (UASB) was evaluated. (Author)

  15. Literature review on cyclic lateral loading effects of mono-bucket foundations

    DEFF Research Database (Denmark)

    Kapitanov, Lachezar Rosenov; Duroska, Peter; Quirante, Cesar Antonio Garcia

    2016-01-01

    and consequently cost-effectiveness compared to other common solutions. The long-term cyclic loading can cause degradation of soil-bucket system stiffness, which yields into accumulated and permanent deformations. Despite of the advantages, there is no standard procedure to design the foundation especially...... calculation is highly demanded at the different design phases. The intention of the current study is to present, review and summarize the existing techniques to assess the effect of cyclic loading on Mono-Bucket foundations while emphasizing the advantage and disadvantage of each of them. Additionally...

  16. Selfenergy effect on the magnetic ordering transition in the mono- and bilayer honeycomb Hubbard model

    Energy Technology Data Exchange (ETDEWEB)

    Honerkamp, Carsten [Institute for Theoretical Solid State Physics, RWTH Aachen University (Germany); JARA - Fundamentals of Future Information Technology, Aachen (Germany)

    2017-11-15

    We investigate the impact of electron self-energy corrections on potential antiferromagnetic ordering instabilities in mono- and bilayer graphene, modeled by a Hubbard-type lattice model with onsite interactions among the electrons, using a self-consistent random phase approximation (RPA). In qualitative agreement with earlier studies we find that the electronic interactions cause non-Fermi liquid behavior at low energies. In self-consistent RPA, the transition scales for antiferromagnetic ordering are renormalized significantly by these self-energy effects, both for interaction-driven and temperature-driven cases. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. Primary studies of trace quantities of green vegetation in Mono Lake area using 1990 AVIRIS data

    Science.gov (United States)

    Chen, Zhi-Kang; Elvidge, Chris D.; Groeneveld, David P.

    1992-01-01

    Our primary results in Jasper Ridge Biological Preserve indicate that high spectral resolution Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data may provide a substantial advantage in vegetation, based on the chlorophyll red edge feature from 700-780 nm. The chlorophyll red edge was detected for green vegetation cover as low as 4.8 percent. The objective of our studies in Mono Lake area is to continue the experiments performed in Jasper Ridge and to examine the persistence of red edge feature of trace quantities of green vegetation for different plant communities with non-uniform soil backgrounds.

  18. Biological significance of lysine mono-, di- and trimethylation on histone and non-histone proteins

    International Nuclear Information System (INIS)

    Perez-Burgos, L.

    2006-01-01

    Histones are the proteins that compact DNA into the repeating unit of chromatin known as the nucleosome. The N-termini of histones are subject to a series of post-translational modifications, one of which is methylation. This modification is termed 'epigenetic' because it extends the information encoded in the genome. Lysines can be mono-, di- or tri-methylated at different positions on histones H1, H3 and H4. In order to study the biological role of histone lysine methylation, antibodies were generated against mono-, di- and trimethylated H3-K9 and H3-27. Indeed, different chromatin domains in the mouse nucleus are enriched in distinct forms of histone lysine methylation, such as pericentric heterochromatin and the inactive X chromosome. Interestingly, heterochromatin in Arabidopsis thaliana is enriched in the mono- and di-, but not the trimethylated form of H3-K9. Furthermore, there exists a hierarchy of epigenetic modifications in which H3-K9 trimethylation is found to be upstream of DNA methylation on mouse major satellites. Histone lysine methylation is also involved in gene regulation upon development. One example is the chicken 61538;-globin locus, a region of facultative chromatin that undergoes a loss of di- and trimethylated H3-K27 in mature red blood cells, concomitant with expression of the 61538;-globin genes. SET-domain proteins are enzymes that methylate histones, but some of them are also able to methylate non-histone substrates. In particular, p53 is methylated by Set9 on lysine 372, G9a and Glp-1 on lysine 373 and by Smyd2 on lysine 370. Smyd2 transcript levels are greatly increased upon irradiation and dimethylated p53-370 specifically binds to 53BP1, a protein involved in recognizing DNA double-stranded breaks upon ionizing radiation. These results argue for a novel role of p53-K370 methylation in the biology of DNA damage. In summary, lysine methylation is a post-translational modification that can occur both on histone and non-histone proteins

  19. Transplacental transfer of monomethyl phthalate and mono(2-ethylhexyl) phthalate in a human placenta perfusion system

    DEFF Research Database (Denmark)

    Mose, Tina; Knudsen, Lisbeth E; Hedegaard, Morten

    2007-01-01

    The transplacental passage of monomethylphtalate (mMP) and mono (2-ethylhexyl) phthalate (mEHP) was studied using an ex vivo placental perfusion model with simultaneous perfusion of fetal and maternal circulation in a single cotyledon. Umbilical cord blood and placental tissue collected both before...... plasma samples. mMP and possibly other short-chained phthalate monoesters in maternal blood can cross the placenta by slow transfer, whereas the results indicate no placental transfer of mEHP. Further studies are recommended....

  20. Large-angle positronium emission for Al(110)

    International Nuclear Information System (INIS)

    Schultz, P.J.; Lynn, K.G.; Frieze, W.E.

    1984-10-01

    Mono-energetic positrons have been used to study the time-of-flight distribution of ortho-positronium (o-Ps) formed just outside the surface of an Al(110) single crystal. The data are interpreted in terms of two predominant angular distributions for the directly formed o-Ps: one that is peaked towards the surface normal and another that is directed towards large angles. These processes are shown to be very sensitive to both oxygen exposure and Ar + ion sputtering. Ps emitted at large-angles may be evidence of formation with electrons propagating in a two-dimensional surface state

  1. Caracterización de niños y adolescentes obesos con síndrome metabólico Characterization of obese children and adolescents with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Yamileisy Santiago Martínez

    2012-03-01

    Full Text Available Introducción: el síndrome metabólico es más frecuente en niños y adolescentes con obesidad. Objetivo: determinar algunas características clínicas, antropométricas y de laboratorio en niños obesos con síndrome metabólico. Métodos: estudio transversal con 59 niños y adolescentes obesos con edades entre 2 y 14 años, seleccionados por muestreo aleatorio simple de 20 consultorios del municipio Urbano Noris, de Holguín, atendidos en abril-mayo de 2010. Las variables fueron: sexo, edad, peso, talla, índice de masa corporal, circunferencia abdominal, presión arterial, colesterol total, triglicéridos, glucemia, HDL-colesterol, LDL-colesterol, microalbuminuria y los índices colesterol total/HDL-colesterol y LDL-colesterol/HDL-colesterol, además, la presencia de hipertensión arterial y diabetes mellitus. Se empleó el análisis de varianza y la prueba c2 en SPSS y nivel de significación del 0,05. La pesquisa se realizó según los criterios cubanos basados en el Programa Nacional de Educación sobre el Colesterol de Estados Unidos. Resultados: la frecuencia del síndrome metabólico fue del 55,9 %. Estos pacientes presentaron valores superiores de la presión arterial, los triglicéridos, la glucemia, LDL-colesterol y de los índices aterogénicos y concentraciones más bajas de lipoproteínas de alta densidad, que el grupo sin síndrome metabólico (n= 26. Se encontró una asociación significativa entre el síndrome metabólico y la hipertensión arterial, no así con la microalbuminuria y la diabetes mellitus. No se encontraron diferencias de género. Conclusiones: es importante el diagnóstico del síndrome metabólico en niños y adolescentes para una mejor caracterización de este estado, y se recomienda una intervención basada en cambios de estilos de vida.Introduction: the metabolic syndrome is more frequent in children and adolescents with obesity. Objective: to determine some clinical, anthropometry and laboratory features

  2. Efeito da sibutramina na redução do peso e no perfil metabólico em indivíduos obesos de uma população brasileira

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Menezes

    2010-12-01

    Full Text Available O objetivo deste trabalho é avaliar a eficácia e a segurança da dose de 20 mg/dia de sibutramina em voluntários obesos, com IMC superior a 35, e compará-las com a dose de 10 mg/dia e à mudança de estilo de vida de pacientes com IMC inferior a 35 (a avaliação e a comparação foram realizadas em um período de 24 semanas. Foram submetidos a um estudo transversal 54 voluntários, distribuídos em três grupos de observação: grupo sem tratamento farmacológico (GMEV, grupo com IMC inferior a 35 e uma dose de 10 mg/ dia de sibutramina (G1 e grupo com IMC superior a 35 e dose de 20 mg/ dia de sibutramina (G2. Os parâmetros avaliados foram peso, circunferência abdominal e perfil metabólico. Os grupos submetidos ao tratamento farmacológico demonstraram maior redução do peso (G1: redução média de 9,4% ; G2: redução média de 20,6% quando comparados a indivíduos sem tratamento farmacológico (GMEV: redução de 3,9%, assim como da circunferência abdominal (redução de 7,1%, 12,8% e 3,1% em G1, G2 e GMEV, respectivamente. Em relação aos achados laboratoriais, foram observados redução da glicemia de jejum (14,8%, 22,9% e 5% em G1, G2 e GMEV, respectivamente, aumento do HDL colesterol (31,2%, 40% e 14,2% em G1, G2 e GMEV, respectivamente e redução do colesterol total (29,0%, 32,8% e 13,7% em G1, G2 e GMEV, respectivamente. Os resultados deste estudo demonstram que a dose de 20 mg de sibutramina é uma indicação segura e eficaz em pacientes obesos com IMC superior a 35. Palavras-chave: Sibutramina. Obesidade. Circunferência Abdominal. Dislipidemia. Diabetes Mellitus, Tipo 2. Ciclobutanos. ABSTRACT Effects of sibutramine on weight reduction and metabolic profile in obese individuals in a brazilian population The aim of this study is to assess the efficacy and safety of an oral daily dose of 20 mg sibutramine in obese volunteers (BMI > 35, in comparison with a dose of 10 mg/day and changed lifestyle in patients whose BMI is

  3. Doença hepática gordurosa não alcoólica em escolares obesos Nonalcoholic fatty liver disease in obese children

    Directory of Open Access Journals (Sweden)

    Fabíola Isabel S. Souza

    2008-06-01

    Full Text Available OBJETIVO: Avaliar a prevalência de alterações hepáticas ao ultra-som e de elevação da alanina aminotransferase (ALT em crianças com sobrepeso e obesidade, além de relacionar a presença de alterações com peroxidação lipídica, perfil lipídico e resistência insulínica. MÉTODOS: Estudo transversal, prospectivo e controlado de 67 crianças com sobrepeso/obesidade (38 do sexo feminino e média de idade de 8,6 anos, pareadas por sexo e idade com 65 eutróficas. A avaliação bioquímica consistiu de perfil lipídico (LDL-c, HDL-c e triglicerídeos; ALT; substâncias reativas ao ácido tiobarbitúrico (TBARS; glicemia e insulina, utilizadas para o cálculo do Homeostasis Model Assessment Insulin Resistance (HOMA-IR. A esteatose hepática, avaliada por ultra-sonografia por um único examinador, foi classificada em difusa leve, moderada e grave. RESULTADOS: Elevação de ALT (>40U/L foi encontrada em 3% e alterações ultra-sonográficas do fígado em 57,4% das crianças com sobrepeso e obesidade. O Grupo Sobrepeso/Obesidade apresentou maior percentual de ALT >18U/L (OR 4,2; p=0,0006 e de hipertrigliceridemia (OR 4,2; p18U/L. CONCLUSÕES: A freqüência de ALT >40U/L foi baixa e a de esteatose foi alta. As alterações ultra-sonográficas hepáticas não mostraram associação com o estado nutricional nem com os níveis de ALT. Por sua vez, triglicerídeos aumentados associaram-se com níveis mais elevados de ALT.OBJECTIVE: To evaluate the prevalence of altered hepatic ultrasound and elevated serum alanine aminotransferase (ALT in overweight and obese children, as well as to relate them to lipid peroxidation, lipid profile and insulin resistance. METHODS: A prospective, controlled, cross-sectional study was performed with 67 overweight and obese children (38 female, mean age of 8,6 years paired by gender and age with 65 eutrophic controls. The following parameters were evaluated: lipid profile (LDL-c, HDL-c, triglycerides, ALT, lipid

  4. Mono and bimetallic nanoparticles of gold, silver and palladium-catalyzed NADH oxidation-coupled reduction of Eosin-Y

    Science.gov (United States)

    Santhanalakshmi, J.; Venkatesan, P.

    2011-02-01

    Mono metallic (Au, Ag, Pd) and bimetallic (Au-Ag, Ag-Pd, Au-Pd) with 1:1 mol stoichiometry, nanoparticles are synthesized using one-pot, temperature controlled chemical method using cetyltrimethylammonium bromide (CTAB) as the capping agent. The particle sizes (Au = 5.6, Ag = 5.0, Pd = 6.0, Au-Ag = 9.2, Ag-Pd = 9.6, Au-Pd = 9.4 nm) are characterized by UV-Vis, HRTEM, and XRD measurements, respectively. CTAB bindings onto mono and bimetallic nanoparticles are analyzed by FTIR spectra. The catalytic activities of mono and bimetallic nanoparticles are tested on the reaction between NADH oxidation and Eosin-Y reduction. The effects of base, pH, ionic strength, nature of mono and bimetallic catalysts are studied and the reaction conditions are optimized. Bimetallic nanoparticles exhibited better catalysis than the mono metallic nanoparticles, which may be due to the electronic effects of the core to shell metal atoms.

  5. Mono and bimetallic nanoparticles of gold, silver and palladium-catalyzed NADH oxidation-coupled reduction of Eosin-Y

    International Nuclear Information System (INIS)

    Santhanalakshmi, J.; Venkatesan, P.

    2011-01-01

    Mono metallic (Au, Ag, Pd) and bimetallic (Au–Ag, Ag–Pd, Au–Pd) with 1:1 mol stoichiometry, nanoparticles are synthesized using one-pot, temperature controlled chemical method using cetyltrimethylammonium bromide (CTAB) as the capping agent. The particle sizes (Au = 5.6, Ag = 5.0, Pd = 6.0, Au–Ag = 9.2, Ag–Pd = 9.6, Au–Pd = 9.4 nm) are characterized by UV–Vis, HRTEM, and XRD measurements, respectively. CTAB bindings onto mono and bimetallic nanoparticles are analyzed by FTIR spectra. The catalytic activities of mono and bimetallic nanoparticles are tested on the reaction between NADH oxidation and Eosin-Y reduction. The effects of base, pH, ionic strength, nature of mono and bimetallic catalysts are studied and the reaction conditions are optimized. Bimetallic nanoparticles exhibited better catalysis than the mono metallic nanoparticles, which may be due to the electronic effects of the core to shell metal atoms.Graphical Abstract

  6. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    Directory of Open Access Journals (Sweden)

    Dongjuan Yuan

    2014-06-01

    Full Text Available Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1 from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1, Penicillium camembertii lipase U-150 (PCL, and Aspergillus oryzae lipase (AOL. Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  7. Ni3Al intermetallide-based alloy: a promising material for turbine blades

    International Nuclear Information System (INIS)

    Kablov, E.N.; Lomberg, B.S.; Buntushkin, V.P.; Golubovskij, E.R.; Muboyadzhyan, S.A.

    2002-01-01

    A consideration is given to properties and structure of a cast intermetallic alloy grade VKNA-4U-mono- with monocrystalline structure in the temperature range of 20-1250 deg C. The influence of long-term heating at 1200 deg C on the stability of alloy mechanical properties is investigated. The advantages of a cast alloy on the basis of alloyed intermetallic compound Ni 3 Al are demonstrated, the processing and physical properties of the alloy are presented [ru

  8. A mono isocentric radiotherapy technique for craniospinal irradiation using asymmetric jaws

    International Nuclear Information System (INIS)

    Isin, G; Oezyar, E.; Guerdalli, S.; Arslan, G.; Uzal, D.; Atahan, I. L.

    1995-01-01

    Dose distribution across the junction of matching of craniospinal fields (lateral cranial fields and posterior spinal field) is important as severe complications may result if the beams overlap or disease may recurs if the gapping is too conservative. Various techniques have been used to achieve an effective transverse plane match and half-beam block technique is one of these techniques. Here, we describe a mono isocentric technique for the treatment of craniospinal fields using the asymmetric jaws of our linear accelerator (Philips SL-25). Before the clinical application of this non-standard technique, basic dosimetry parameters are evaluated. Asymmetric collimator dose distributions for various asymmetric field sizes were obtained and compared with symmetric dose distributions for 6 MV x-ray. A computerized 3-D water phantom with a pair of ionization chambers (reference and field) was used for dose profiles, isodose distributions and Percentage Depth Dose (PDD) for various asymmetric field sizes and different off axis distances. The measured values of off axis ratios for the interested depths were used in MU calculations. This new mono isocentric technique provides an ideal dose distribution at match-line as there is no need to move the patient during treatment. Use of heavy secondary cerrobend blocks (beam splitters) is eliminated. This technique provides the ease of consequent daily set-up's and fulfills the requirements for a conformal radiotherapy

  9. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    Directory of Open Access Journals (Sweden)

    Mohamed T. Ghoneim

    2015-12-01

    Full Text Available In today’s digital world, complementary metal oxide semiconductor (CMOS technology enabled scaling of bulk mono-crystalline silicon (100 based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm mono-crystalline (100 silicon (detached from bulk substrate by utilizing deterministic pattern of porous network of vertical “through silicon” micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs with high-κ/metal gate stacks.

  10. Mono-carboxylate conversion coatings for AZ31 Mg alloy protection

    Energy Technology Data Exchange (ETDEWEB)

    Frignani, A.; Grassi, V.; Zucchi, F.; Zanotto, F. [Corrosion Study Centre A. Dacco, University of Ferrara (Italy)

    2011-11-15

    Conversion coatings on a magnesium alloy were obtained by dipping AZ31 specimens in aqueous solutions of sodium salts of mono-carboxylic acids (stearic, palmitic, myristic, lauric, mono-carboxylate ion concentration from 1 to 5 mM, depending on the salt solubility) for 24 and 72 h at room temperature, or 24 h at 50 C. The influence exerted by the treatment time, bath temperature and alkyl chain length on the efficiency of these coatings was studied. The performances of the coatings were evaluated by potentiodynamic polarization curve recording after 1 h immersion in 0.05 M Na{sub 2}SO{sub 4} solution, while their temporal evolution was monitored by electrochemical impedance spectroscopy (EIS) spectra during 24 h. Further and long lasting tests were carried out also in 0.1 M NaCl solution. The efficiency of the coatings depended on the aliphatic chain length, and increased as the treatment time and the bath temperature were increased. The coating of lower homologue only hindered the cathodic process, while those of the higher homologues markedly inhibited the anodic process too. The best performances were displayed by 24 h-50 C stearic conversion coating, which maintained a very high efficiency for over 800 h immersion in 0.05 M sulphate solution. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  11. The MONOS memory transistor: application in a radiation-hard nonvolatile RAM

    International Nuclear Information System (INIS)

    Brown, W.D.

    1985-01-01

    The MONOS (metal-oxide-nitride-oxide-silicon) device is a prime candidate for use as the nonvolatile memory element in a radiation-hardened RAM (random-access memory). The endurance, retention and radiation properties of MONOS memory transistors have been studied as a function of post nitride deposition annealing. Following the nitride layer deposition, all devices were subjected to an 800 0 C oxidation step and some were then annealed at 900 0 C in nitrogen. The nitrogen anneal produces an increase in memory window size of approximately 40%. The memory window center of the annealed devices is shifted toward more positive voltages and is more stable with endurance cycling. Endurance cycling to 10 9 cycles produces a 20% increase in memory window size and a 60% increase in decay rate. For a radiation total dose of 10 6 rads (Si), the memory window size is essentially unchanged and the decay rate increases approximately 13%. A combination of 10 9 cycles and 10 6 rads (Si) reduces the decades of retention (in sec) from 6.3 to 4.3 for a +- 23-V 16-μsec write/erase pulse. (author)

  12. [Synthesis and biological activity of 2,3-secotriterpene acid mono- and diamides].

    Science.gov (United States)

    Tolmacheva, I A; Igosheva, E V; Vikharev, Iu B; Grishko, V V; Savinova, O V; Boreko, E I; Eremin, V F

    2013-01-01

    Four types of amide (C3; C28; C3-C28) conjugates based on 2,3-seco-18alphaH-oleanane and 2,3-secolupane mono- and dicarboxylic acids were synthesized. The range of diamide derivatives was supplemented with C3-C3' and C28-C28' dicondensed amides with two A-secotriterpene backbones educed by reacting monocarboxylic A-secoacids with biogenic amino acid lysine. Compounds with inhibitory action against herpes virus reproduction (EC50 8.7 and 4.1 McM) were found among the synthesized mono- and diamide derivatives containing an ethyl-beta-alaninate fragment. It has been ascertained that diamide with ethyl-beta-alaninate fragment combines anti-herpes virus properties and anti-HIV activity (EC50 5.1 McM). For active compounds, the maximum non-toxic concentration (MNTC)/EC50 ratios ranges from 9.7 to 40.8. The synthesized amide conjugates do not exhibit any marked cytotoxic effects against human tumor cell lines rabdomiosarcoma RD TE32, A549 lung carcinoma and melanoma MS.

  13. Radiation degradation and hemolytic toxicity evaluation of mono azo reactive dyes

    International Nuclear Information System (INIS)

    Saeed, Q.U.; Bhatti, I.A.; Ashraf, A.

    2017-01-01

    Monoazo reactive dyes have been synthesized and subjected to degradation before their application. Advanced oxidation process has been recognized as a promising radiation technology for the remediation of hazardous organic compounds. Radiation induced degradation of two mono azo reactive dyes have been tried at different absorbed dose, 5 kGy,10 kGy and 15 kGy. Aqueous solutions of these dyes were treated with gamma radiation using Cs 137 radiation source at Nuclear Institute of Agriculture and Biology (NIAB) Faisalabad. Dyes were evaluated spectrophotometrically by UV-visible and fourier transform infra red (FT-IR) spectroscopic techniques before and after irradiation to analyse their percentage decolorization and degradation. Maximum percentage decolorization of 93% and 63% was achieved for mono azo dyes D1 and D2 at 15 kGy absorbed dose. Toxicity study of these dyes was also tested by haemolytic activity assay. Percentage haemolytic activity of untreated dyes was found within permissible limit showing non toxicity of dye solutions. (author)

  14. Aspirin mono-therapy continuation does not result in more bleeding after knee arthroplasty.

    Science.gov (United States)

    Schwab, Pierre-Emmanuel; Lavand'homme, Patricia; Yombi, JeanCyr; Thienpont, Emmanuel

    2017-08-01

    Current clinical practice guidelines sometimes still recommend stopping aspirin five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose aspirin mono-therapy continuation does not cause more total blood loss than knee arthroplasty performed without aspirin. Blood loss would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for patients who benefit from multimodal bleeding control measures. A database of all patients undergoing knee arthroplasty between 2006 and 2014 was analysed. Demographic, surgical and complete blood workup data were collected. A retrospective comparison study analysed both groups in terms of blood loss, by mean calculated blood loss as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) patients underwent surgery without interrupting their aspirin therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m 2 . The control group consisted of 403 (102 UKA and 301 TKA) patients who were not under aspirin, or any other anti-platelet agent. Mean (SD) age was 65 (10) (p aspirin mono-therapy for cardiovascular prevention. III.

  15. Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

    Directory of Open Access Journals (Sweden)

    Andrea Bistrović

    2017-11-01

    Full Text Available A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolylphenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1 cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma and p38 MAP (mitogen-activated protein kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.

  16. Rapid identification of vibrio-cholerae O1 by coaglutination test using mono-specifis antibody

    Directory of Open Access Journals (Sweden)

    Bazargan SA

    1996-07-01

    Full Text Available In our investigation, rabbit hyper-immune serum to V.cholerae ogawa was absorbed with V.cholerae inaba whole-cells and vice versa. Applying ammonium sulphate precipitation method, mono-specific g globulins were purified and concentrated from the absorbed whole serum. These antibodies were fixed on staphylococcus cowan 1 NCTC-8325 whole-cells, using different chemical fixatives. It was observed that maximum fixation of g globulin to protein-A was achieved by 1-propanol 50% at 3 hours, which revealed through single radial immuno-diffusion techniqe. The rectal swab samples were cultured in an enrichment bile-peptons broth. After 5 hours 37°C while agitations, one drop of each sample was mixed with one drop of vibrio-cholerae bivalent mono-specific coagglutination reagent (VBCR. The results were read after 2 to 3 minutes. Finally though statistical analysis sensitivity and specificity of coagglutination test were calculated to be 95.1% and 99.2% respectively, when compared to positive & negative controls and conventional culture methods. Using VBCR, coagglutination test can be therefore considered as a simple, reliable and rapid method to detect V.cholerae O1 in the stool of patients in endemic area and less equipped laboratories

  17. Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

    Directory of Open Access Journals (Sweden)

    Wen Zhu

    2013-12-01

    Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

  18. N resource of grasses and N2-fixation of alfalfa in mono-culture and mixture

    International Nuclear Information System (INIS)

    Zhu Shuxiu

    1992-01-01

    The N behavior in alfalfa and gramineous forage grasses, tall fescue, siberian wild rye, wheat grass and awnless brome were studied in potting and pasture experiments in 1986-1988 by using 15 N isotope dilution technique. Comparison was made between the mixed culture and mono-culture. The % Ndff and %Ndfs of grasses were decreased by 14.19% and 20.76% respectively, while %Ndfa of alfalfa was increased by 20.22% in mixed culture as compared with mono-culture. The 15 N and soil N uptake data revealed that this enhancement was largely due to a lower competitive ability for soil N by alfalfa than by grass in mixed stands, causing the alfalfa to depend more on atmospheric N 2 fixation. 20.62%of N of grasses in mixed culture was from the N 2 -fixation by alfalfa, causing N level in root-sphere of alfalfa decreasing, which was considered to be one of the reasons that %Ndfa increased in mixed culture. N transfer may be carried out by the decomposition of roots and nodules of alfalfa plants

  19. Production of D- and L-Lactic Acid by Mono- and Mixed Cultures of Lactobacillus sp.

    Directory of Open Access Journals (Sweden)

    Antonija Trontel

    2011-01-01

    Full Text Available Batch cultivation of monoculture of Lactobacillus sp. and two–strain mixed culture of Lactobacillus sp. and Lactobacillus amylovorus DSM 20531T was carried out with the aim of producing L-(+- and D-(–/L-(+-lactic acid to be implemented in poly(lactic acid polymer production. Metabolic capacity of two Lactobacillus strains to ferment different carbon sources (glucose, sucrose or soluble starch during cultivation in MRS medium at 40 °C, in a laboratory-scale stirred tank bioreactor was defined. Lactobacillus sp. showed similar affinity towards mono- and disaccharide substrates, which were homofermentatively converted mostly to L-(+-lactic acid. L. amylovorus DSM 20531T has been characterized as a D/L-lactate producer and it is capable of conducting simultaneous saccharification and fermentation. Due to the interaction of Lactobacillus sp. with L. amylovorus DSM 20531T, starch was hydrolysed and fermented to the mixture of L-(+- and D-(–-lactic acid. Modified Luedeking-Piret kinetics used for the description of substrate utilization, growth of mono- and mixed cultures and production of lactic acid stereoisomers showed good agreement with experimental data.

  20. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    KAUST Repository

    Ghoneim, Mohamed T.; Fahad, Hossain M.; Hussain, Aftab M.; Rojas, Jhonathan Prieto; Sevilla, Galo T.; Alfaraj, Nasir; Lizardo, Ernesto B.; Hussain, Muhammad Mustafa

    2015-01-01

    In today’s digital world, complementary metal oxide semiconductor (CMOS) technology enabled scaling of bulk mono-crystalline silicon (100) based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm) mono-crystalline (100) silicon (detached from bulk substrate) by utilizing deterministic pattern of porous network of vertical “through silicon” micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs) with high-κ/metal gate stacks.

  1. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    KAUST Repository

    Ghoneim, Mohamed T.

    2015-12-11

    In today’s digital world, complementary metal oxide semiconductor (CMOS) technology enabled scaling of bulk mono-crystalline silicon (100) based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm) mono-crystalline (100) silicon (detached from bulk substrate) by utilizing deterministic pattern of porous network of vertical “through silicon” micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs) with high-κ/metal gate stacks.

  2. Searches for Dark Matter via Mono-W Production in Inert Doublet Model at the LHC

    Science.gov (United States)

    Wan, Neng; Li, Niu; Zhang, Bo; Yang, Huan; Zhao, Min-Fu; Song, Mao; Li, Gang; Guo, Jian-You

    2018-05-01

    The Inert Doublet Model (IDM) is one of the many beyond Standard Model scenarios with an extended scalar sector, which provide a suitable dark matter particle candidate. Dark matter associated visible particle production at high energy colliders provides a unique way to determine the microscopic properties of the dark matter particle. In this paper, we investigate that the mono-W + missing transverse energy production at the Large Hadron Collider (LHC), where W boson decay to a lepton and a neutrino. We perform the analysis for the signal of mono-W production in the IDM and the Standard Model (SM) backgrounds, and the optimized criteria employing suitable cuts are chosen in kinematic variables to maximize signal significance. We also investigate the discovery potential in several benchmark scenarios at the 14 TeV LHC. When the light Z2 odd scalar higgs of mass is about 65 GeV, charged Higgs is in the mass range from 120 GeV to 250 GeV, it provides the best possibility with a signal significance of about 3σ at an integrated luminosity of about 3000 fb‑1. Supported by the National Natural Science Foundation of China under Grant Nos. 11205003, 11305001, 11575002, the Key Research Foundation of Education Ministry of Anhui Province of China under Grant Nos. KJ2017A032, KJ2016A749, KJ2013A260, and Natural Science Foundation of West Anhui University under Grant No. WXZR201614

  3. Two coarse pyroclastic flow deposits, northern Mono-Inyo Craters, CA

    Science.gov (United States)

    Dennen, R. L.; Bursik, M. I.; Stokes, P. J.; Lagamba, M.; Fontanella, N.; Hintz, A. R.; Jayko, A. S.

    2010-12-01

    The ~1350 A.D., rhyolitic North Mono eruption, Mono-Inyo Craters, CA, included the extrusion and destruction of Panum Dome and associated clastic deposits. Overlying the tephras of the North Mono sequence, the Panum deposits include a block-and-ash flow (BAF) deposit, covering ~3.5 km2. Blocks within the deposit are typically lithic rhyolite and banded gray micro-vesicular glass, showing white, almost powdery marks ranging from circular to linear in shape. These marks are interpreted as friction marks resulting from collisions between clasts. The deposit also contains bread-crusted obsidians with pressed-in clasts as well as reticulite with a bread-crusted surface texture. Near the centerline of the deposit is a ridge-topping train of jigsaw fractured blocks, often with reddish-orange alteration. One house sized jigsaw block sits upstream of a long, thinning pile of reddish orange debris; this “flow shadow” indicates that the block remained relatively stationary while the block and ash flow continued to propagate around it. The bread-crusted reticulite is most common at proximal localities. It is proposed that the dome destruction included a debris avalanche emplacing the train of jigsaw fractured blocks and creating a topographic high, the block-and-ash flow (the farthest reaching deposit from this event) which flowed around the debris avalanche deposits, and a final “lateral expansion” of a magma foam, creating the reticulite seen concentrated at proximal locations. Another coarse pyroclastic flow (here termed the “lower blast deposit”) underlies the North Mono tephra. It is more obsidian rich and finer grained than the Panum BAF. The lower blast deposit may have originated from Pumice Pit vent, which is now capped with an older dome ~0.5 km southeast of Panum. The lower blast deposit extends farther from the Panum vent than does the Panum BAF deposit, and apparently was mistaken for the Panum BAF deposit by previous workers. Hence the run

  4. Long-term thermophilic mono-digestion of rendering wastes and co-digestion with potato pulp

    International Nuclear Information System (INIS)

    Bayr, S.; Ojanperä, M.; Kaparaju, P.; Rintala, J.

    2014-01-01

    Highlights: • Rendering wastes’ mono-digestion and co-digestion with potato pulp were studied. • CSTR process with OLR of 1.5 kg VS/m 3 d, HRT of 50 d was unstable in mono-digestion. • Free NH 3 inhibited mono-digestion of rendering wastes. • CSTR process with OLR of 1.5 kg VS/m 3 d, HRT of 50 d was stable in co-digestion. • Co-digestion increased methane yield somewhat compared to mono-digestion. - Abstract: In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55 °C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion intermediate products viz., volatile fatty acids (VFAs), long chain fatty acids (LCFAs) and ammonia nitrogen (NH 4 -N and/or free NH 3 ) can cause process imbalance during the digestion. Mono-digestion of rendering wastes at an organic loading rate (OLR) of 1.5 kg volatile solids (VS)/m 3 d and hydraulic retention time (HRT) of 50 d was unstable and resulted in methane yields of 450 dm 3 /kg VS fed . On the other hand, co-digestion of rendering wastes with potato pulp (60% wet weight, WW) at the same OLR and HRT improved the process stability and increased methane yields (500–680 dm 3 /kg VS fed ). Thus, it can be concluded that co-digestion of rendering wastes with potato pulp could improve the process stability and methane yields from these difficult to treat industrial waste materials

  5. Biofilm formation and disinfectant resistance of Salmonella sp. in mono- and dual-species with Pseudomonas aeruginosa.

    Science.gov (United States)

    Pang, X Y; Yang, Y S; Yuk, H G

    2017-09-01

    This study aimed to evaluate the biofilm formation and disinfectant resistance of Salmonella cells in mono- and dual-species biofilms with Pseudomonas aeruginosa, and to investigate the role of extracellular polymeric substances (EPS) in the protection of biofilms against disinfection treatment. The populations of Salmonella in mono- or dual-species biofilms with P. aeruginosa on stainless steel (SS) coupons were determined before and after exposure to commercial disinfectant, 50 μg ml -1 chlorine or 200 μg ml -1 Ecolab ® Whisper™ V (a blend of four effective quaternary ammonium compounds (QAC)). In addition, EPS amount from biofilms was quantified and biofilm structures were observed using scanning electron microscopy (SEM). Antagonistic interactions between Salmonella and P. aeruginosa resulted in lower planktonic population level of Salmonella, and lower density in dual-species biofilms compared to mono-species biofilms. The presence of P. aeruginosa significantly enhanced disinfectant resistance of S. Typhimurium and S. Enteritidis biofilm cells for 2 days, and led to an average of 50% increase in polysaccharides amount in dual-species biofilms than mono-species biofilms of Salmonella. Microscopy observation showed the presence of large microcolonies covered by EPS in dual-species biofilms but not in mono-species ones. The presence of P. aeruginosa in dual-species culture inhibited the growth of Salmonella cells in planktonic phase and in biofilms, but protected Salmonella cells in biofilms from disinfection treatment, by providing more production of EPS in dual-species biofilms than mono-species ones. This study provides insights into inter-species interaction, with regard to biofilm population dynamics and disinfectant resistance. Thus, a sanitation protocol should be designed considering the protective role of secondary species to pathogens in biofilms on SS surface which has been widely used at food surfaces and manufacturers. © 2017 The Society

  6. Long-term thermophilic mono-digestion of rendering wastes and co-digestion with potato pulp

    Energy Technology Data Exchange (ETDEWEB)

    Bayr, S., E-mail: suvi.bayr@jyu.fi; Ojanperä, M.; Kaparaju, P.; Rintala, J.

    2014-10-15

    Highlights: • Rendering wastes’ mono-digestion and co-digestion with potato pulp were studied. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was unstable in mono-digestion. • Free NH{sub 3} inhibited mono-digestion of rendering wastes. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was stable in co-digestion. • Co-digestion increased methane yield somewhat compared to mono-digestion. - Abstract: In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55 °C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion intermediate products viz., volatile fatty acids (VFAs), long chain fatty acids (LCFAs) and ammonia nitrogen (NH{sub 4}-N and/or free NH{sub 3}) can cause process imbalance during the digestion. Mono-digestion of rendering wastes at an organic loading rate (OLR) of 1.5 kg volatile solids (VS)/m{sup 3} d and hydraulic retention time (HRT) of 50 d was unstable and resulted in methane yields of 450 dm{sup 3}/kg VS{sub fed}. On the other hand, co-digestion of rendering wastes with potato pulp (60% wet weight, WW) at the same OLR and HRT improved the process stability and increased methane yields (500–680 dm{sup 3}/kg VS{sub fed}). Thus, it can be concluded that co-digestion of rendering wastes with potato pulp could improve the process stability and methane yields from these difficult to treat industrial waste materials.

  7. PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model

    OpenAIRE

    He, Jin; Li, Qiuyan; Fang, Suyun; Guo, Ying; Liu, Tongxin; Ye, Jianhua; Yu, Zhengquan; Zhang, Ran; Zhao, Yaofeng; Hu, Xiaoxiang; Bai, Xueyuan; Chen, Xiangmei; Li, Ning

    2015-01-01

    PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide. Due to the marked differences in the lifespan, size, anatomy, and physiology from humans, rodent ADPKD models cannot fully mimic the disease. To obtain a large animal model that recapitulates the disease, we constructed a mini-pig model by mono-allelic knockout (KO) of PKD1 using zinc finger nuclease. The mono-allelic KO pigs had lower PKD1 expression than t...

  8. Synergistic extraction of Am(III) using HTTA and bi-functional (DHDECMP) and mono-functional (TBP) donors

    International Nuclear Information System (INIS)

    Pai, S.A.; Lohithakshan, K.V.; Mithapara, P.D.; Aggarwal, S.K.

    1999-01-01

    The equilibrium constant (log Ks) for the organic phase synergistic reaction for Am(III)-HTTA system with bi-functional neutral donor di-hexyl di-ethyl carbamoylmethyl phosphonate (DHDECMP) was found to be about two orders of magnitude higher than that of the mono-functional neutral donor (TBP) with comparable basicity values. This log Ks value along with a large positive entropy change with DHDECMP compared to that with TBP confirms that the neutral donors like DHDECMP behave as bi-functional, in sharp contrast to its mono-functional behaviour in Pu(VI). (author)

  9. Lake Level Changes in the Mono Basin During the Last Deglacial Period

    Science.gov (United States)

    Wang, X.; Ali, G.; Hemming, S. R.; Zimmerman, S. R. H.; Stine, S. W.; Hemming, G.

    2014-12-01

    Mono Basin, located in the southwestern corner of the US Great Basin, has long been known to have experienced large lake level changes, particularly during the last deglaciation. But until recently it was not possible to establish a reliable lake level time series. We discovered many visually clean, white, shiny, dense calcite samples in the basin, associated with tufa deposits from high terraces. Their low thorium, but high uranium contents allow precise and reproducible U/Th age determinations. A highly resolved history of a minimum lake level through the last deglaciation can therefore be inferred based on sample locations and their ages. We found that the lake level reached ~2030 m asl at ~20.4 ka, evidenced by calcite coatings on a tufa mound at the upper Wilson Creek. The lake then rose to ~2075 m by ~19.1 ka, shown by calcite cements on conglomerates from the Hansen Cut terrace. The lake climbed to at least ~2140 m at ~15.9 ka, indicated by beach calcites from the east Sierra slope. Such timing of the highest lake stand, occurring within Heinrich Stadial 1, is reinforced by U/Th dates on calcite coatings from widespread locations in the basin, including the Bodie Hills and Cowtrack Mountains. The lake then dropped rapidly to ~2075 m at ~14.5 ka. It stood near this height over the next ~300 years, evidenced by a few-centimeter thick, laminated calcite rims on the Goat Ranch tufa mounds. It subsequently plunged to ~2007 m at ~13.8 ka, indicated by calcite coatings from cemetery road tufa mounds. The lake level came back to ~2030 m at ~12.9 ka, as seen in upper Wilson Creek tufa mounds. The lake level had a few fluctuations within the Younger Dryas, and even shot up to ~2075 m at ~12.0 ka. It then fell to levels in accord with Holocene climatic conditions. Relative to the present lake level of ~1950 m, Mono Lake broadly stood high during Heinrich Stadial 1 and Younger Dryas, when the climate was extremely cold over the North Atlantic, and the Asian monsoon was

  10. Anaerobic halo- alkaliphilic bacterial community of athalassic, hypersaline Mono lake and Owens Lake in California

    Science.gov (United States)

    Pikuta, Elena V.; Detkova, Ekaterina N.; Bej, Asim K.; Marsic, Damien; Hoover, Richard B.

    2003-02-01

    The bacterial diversity of microbial extremophiles from the meromictic, hypersaline Mono Lake and a small evaporite pool in Owens Lake of California was studied. In spite of these regions had differing mineral background and different concentrations of NaCl in water they contain the same halo- alkaliphiles anaerobic bacterial community. Three new species of bacteria were detected in this community: primary anaerobe, dissipotrophic saccharolytic spirochete Spirochaeta americana strain AspG1T, primary anaerobe which is proteolytic Tindallia californiensis strain APOT, and secondary anaerobe, hydrogen using Desulfonatronum thiodismutans strain MLF1T, which is sulfate- reducer with chemo-litho-autotrophic metabolism. All of these bacteria are obligate alkaliphiles and dependent upon Na+ ions and CO32- ions in growth mediums. It is interesting that closest relationships for two of these species were isolates from samples of equatorial African soda Magadi lake: Spirochaeta americana AspG1T has 99.4% similarity on 16S rDNA- analyses with Spirochaeta alkalica Z- 7491T, and Tindallia californiensis APOT has 99.1% similarity with Tindallia magadiensis Z-7934T. But result of DNA-DNA- hybridization demonstrated less then 50% similarity between Spirochaeta americana AspG1T and Spirochaeta alkalica Z-7491T. Percent of homology between Tindallia californiensis APOT and Tindallia magadiensis Z-7934T is only 55%. The sulfate-reducer from the alkalic anaerobic community of Magadi lake Desulfonatronovibrio hydrogenovorans Z-7935T was phylogenetically distant from this sulfate-reducer in Mono lake, but genetically closer (99.7% similarity) to the sulfate-reducer, isolated from Central Asian alkalic lake Khadyn in Siberia Desulfonatronum lacustre Z-7951T. The study of key enzymes (hydrogenase and CO- hydrogenase) in Tindallia californiensis APOT and Desulfonatronum thiodismutans MLF1T showed the presence of high activity of both the enzymes in first and only hydrogenase in second

  11. Mechanism of manganese (mono and di) telluride thin-film formation and properties

    Science.gov (United States)

    Sharma, Raj Kishore; Singh, Gurmeet; Shul, Yong Gun; Kim, Hansung

    2007-03-01

    Mechanistic studies on the electrocrystallization of manganese telluride (MnTe) thin film are reported using aqueous acidic solution containing MnSO 4 and TeO 2. Tartaric acid was used for the inhibition of hydrated manganese oxide anodic growth at counter electrode. A detailed study on the mechanistic aspect of electrochemical growth of MnTe using cyclic voltametry is carried out. Conditions for electrochemical growth of manganese mono and di telluride thin films have been reported using cyclic voltammetric scans for Mn 2+, Te 4+ and combined Mn 2+ and Te 4+. X-ray diffraction showed the formation of polycrystalline MnTe films with cubic, hexagonal and orthorhombic mixed phases. MnTe film morphology was studied using scanning electron microscope. Susceptibility and electrical characterization supports the anti-ferromagnetic behavior of the as-deposited MnTe thin film.

  12. Study of gamma propagation by using the ZEUS mono-kinetic code

    International Nuclear Information System (INIS)

    Vergnaud, Therese

    1969-10-01

    As studies of radiation protection often require the knowledge of heating due to capture gamma of thermal neutrons, the authors report an attempt of assessment of neutrons and γ propagation by using the same code (Zeus) which computes particle scattering by implementing a mono-kinetic Monte Carlo method. With this method, it is possible to study rather complex geometries and gamma source distributions directly obtained by a previous calculation of thermal neutrons. However, this method is not suitable for the study of energy degradation of gamma rays during their propagation. An approximate shock law is used to take shock-induced energy loss into account. This method is tested for different materials or media (either light like water and aluminium, or heavy like iron). Results are compared with those obtained by Goldstein with the method of moments. Results obtained by using Zeus are discussed: some of them appear to be over-estimated [fr

  13. Mono-domain YBa2Cu3Oy superconductor fabrics prepared by an infiltration process

    International Nuclear Information System (INIS)

    Sudhakar Reddy, E.; Noudem, J.G.; Tarka, M.; Schmitz, G.J.

    2000-01-01

    A novel process for the fabrication of a new form of YBa 2 Cu 3 O y (123) superconducting material, with the dimensions of a thick film and the microstructure of a melt-textured single-domain bulk is described. The process allows the fabrication of 123 as a self-supporting fabric or as a thick film on various substrate materials. The process, which is generic and economical, uses commercially available Y 2 O 3 fabrics as a precursor material. The Y 2 O 3 cloth is infiltrated with barium cuprates and copper oxides from a liquid-phase source, then converted into Y 2 BaCuO 5 (211) phase and eventually to 123. The nucleation and growth of the 123 phase is controlled by seeding the cloth with an oriented heterogeneous MgO or Nd123 seed. Interesting application areas for the new form of the 123 mono-domain fabric are discussed. (author)

  14. Derivation of the low Mach number diphasic system. Numerical simulation in mono-dimensional geometry

    International Nuclear Information System (INIS)

    Dellacherie, St.

    2004-01-01

    This work deals with the derivation of a diphasic low Mach number model obtained through a Mach number asymptotic expansion applied to the compressible diphasic Navier Stokes system, expansion which filters out the acoustic waves. This approach is inspired from the work of Andrew Majda giving the equations of low Mach number combustion for thin flame and for perfect gases. When the equations of state verify some thermodynamic hypothesis, we show that the low Mach number diphasic system predicts in a good way the dilatation or the compression of a bubble and has equilibrium convergence properties. Then, we propose an entropic and convergent Lagrangian scheme in mono-dimensional geometry when the fluids are perfect gases and we propose a first approach in Eulerian variables where the interface between the two fluids is captured with a level set technique. (author)

  15. Monojets and mono-photons from light higgsino pair production at LHC14

    CERN Document Server

    Baer, Howard; Tata, Xerxes

    2014-01-01

    Naturalness arguments imply the existence of higgsinos lighter than 200-300 GeV. However, because these higgsinos are nearly mass degenerate, they release very little visible energy in their decays, and signals from electroweak higgsino pair production typically remain buried under Standard Model backgrounds. Moreover, gluinos, squarks and winos may plausibly lie beyond the reach of the LHC14, so that signals from naturalness-inspired supersymmetric models may well remain hidden via conventional searches. We examine instead prospects for detecting higgsino pair production via monojets or mono-photons from initial state radiation. We find typical signal-to-background rates at best at the 1 % level, leading to rather pessimistic conclusions regarding detectability via these channels.

  16. Static and Ultrafast Transient Photophysics of Mono- and Dual-Branched Triarylamines

    International Nuclear Information System (INIS)

    Feng-Ming, Li; Wen-Ke, Feng; Shu-Feng, Wang; Qi-Huang, Gong; Fan-Shun, Meng; He, Tian

    2010-01-01

    Mono- and dual-branched molecules, {4-[2-(4-benzothiazol-2-yl-phenyl)-vinyl]-phenyl}-(4-methoxy-phenyl) -phenyl-amine (BS1) and bis-{4-[2-(4-benzothiazol-2-yl-phenyl)-vinyl]-phenyl}-(4-methoxy-phenyl) -phenyl-amine (BS2), are investigated with one- and two-photon static spectroscopy, and the femtosecond fluorescence up-conversion technique. The molecules show branch-based fluorescence emission at low quantum yield. Ultrafast non-radiative decay on a picosecond time scale is found and is attributed to intramolecular charge-transfer bridged by the central triphenylamine. The two-photon absorption cross-sections of BS1 and BS2 are 19.1 and 19.4 GM, respectively. (cross-disciplinary physics and related areas of science and technology)

  17. Synthesis of the mono- and di(4-(1,1,3,3-tetramethylbutyl)) phosphoric acids

    International Nuclear Information System (INIS)

    Elias, H.; Zaoui, A.; Attou, M.; Hadj Bachir, D.; Bouzidi, N.; Didi, M.

    1995-09-01

    This work is related to the synthesis of organophosphorus extracting agents used in purification of heavy metals such as uranium. The mono- and di (4-(1,1,3,3- tetramethylbutyl)) phenyl phosphoric acids, respectively MOPPA and DOPPA, are synthesizd by reaction of phosphorus pentoxid with 4(1,1,3,3-tetramethylbuthyl)) phenol. the separation of MOPPA from DOPPA is realised by liquid-liquid extraction. The Characterization, carried out by infrared uv-visible spectrophotometries, ph-metry and mass spectrometry, has confirmed the identity of the synthesized products. This study also showed that the products proportions are comporable to those of the homologous products obtained with 2-ethylbexanol in the same synthesis conditions

  18. Simulation study of accelerator based quasi-mono-energetic epithermal neutron beams for BNCT.

    Science.gov (United States)

    Adib, M; Habib, N; Bashter, I I; El-Mesiry, M S; Mansy, M S

    2016-01-01

    Filtered neutron techniques were applied to produce quasi-mono-energetic neutron beams in the energy range of 1.5-7.5 keV at the accelerator port using the generated neutron spectrum from a Li (p, n) Be reaction. A simulation study was performed to characterize the filter components and transmitted beam lines. The feature of the filtered beams is detailed in terms of optimal thickness of the primary and additive components. A computer code named "QMNB-AS" was developed to carry out the required calculations. The filtered neutron beams had high purity and intensity with low contamination from the accompanying thermal, fast neutrons and γ-rays. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Mono- and Di-Alkylation Processes of DNA Bases by Nitrogen Mustard Mechlorethamine.

    Science.gov (United States)

    Larrañaga, Olatz; de Cózar, Abel; Cossío, Fernando P

    2017-12-06

    The reactivity of nitrogen mustard mechlorethamine (mec) with purine bases towards formation of mono- (G-mec and A-mec) and dialkylated (AA-mec, GG-mec and AG-mec) adducts has been studied using density functional theory (DFT). To gain a complete overview of DNA-alkylation processes, direct chloride substitution and formation through activated aziridinium species were considered as possible reaction paths for adduct formation. Our results confirm that DNA alkylation by mec occurs via aziridine intermediates instead of direct substitution. Consideration of explicit water molecules in conjunction with polarizable continuum model (PCM) was shown as an adequate computational method for a proper representation of the system. Moreover, Runge-Kutta numerical kinetic simulations including the possible bisadducts have been performed. These simulations predicted a product ratio of 83:17 of GG-mec and AG-mec diadducts, respectively. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Transient heating and evaporation of moving mono-component liquid fuel droplets

    DEFF Research Database (Denmark)

    Yin, Chungen

    2016-01-01

    of which the flow and energy transport equations are numerically solved using the finite volume method. The computer code for the model is developed in a generic 3D framework and verified in different ways (e.g., by comparison against analytical solutions for simplified cases, and against experimental......This paper presents a complete description of a model for transient heating and evaporation of moving mono-component liquid fuel droplets. The model mainly consists of gas phase heat and mass transfer analysis, liquid phase analysis, and droplet dynamics analysis, which address the interaction...... between the moving droplets and free-stream flow, the flow and heat and mass transfer within the droplets, and the droplet dynamics and size, respectively. For the liquid phase analysis, the droplets are discretized into a number of control volumes along the radial, polar and azimuthal directions, on each...

  1. Endospores of B subtilis are pyrogenic and activate Mono Mac 6 cells

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, Erik W; Christensen, Jens D

    2003-01-01

    interleukin-6. Lipopolysaccharides (LPS) dose-dependently induce interleukin-6 release, but the curve differs from that of LTA both in shape and offset. The interleukin-6 secretion induced by LPS, LTA and B. subtilis bacteria can be blocked by 73-85% by an antibody directed against CD14, whereas the antibody......The monocytic cell line Mono Mac 6 is sensitive to pyrogens and interleukin-6 secretion is induced after exposure to pyrogens. The aim of this study is to examine the pyrogenic activity and the interleukin-6-inducing capacity of the Gram-positive B. subtilis bacteria, endospores and isolated cell...... in a sandwich immunoassay. B. subtilis bacteria and endospores induce interleukin-6 in a dose-dependent manner. Endospores are less potent than bacteria. Lipoteichoic acid (LTA) isolated from B. subtilis induces interleukin-6 in a dose-dependent manner, whereas muramyl dipeptide (MDP) is unable to induce...

  2. Anomalous I-V curve for mono-atomic carbon chains

    International Nuclear Information System (INIS)

    Song Bo; Fang Haiping; Sanvito, Stefano

    2010-01-01

    The electronic transport properties of mono-atomic carbon chains were studied theoretically using a combination of density functional theory and the non-equilibrium Green's functions method. The I-V curves for the chains composed of an even number of atoms and attached to gold electrodes through sulfur exhibit two plateaus where the current becomes bias independent. In contrast, when the number of carbon atoms in the chain is odd, the electric current simply increases monotonically with bias. This peculiar behavior is attributed to dimerization of the chains, directly resulting from their one-dimensional nature. The finding is expected to be helpful in designing molecular devices, such as carbon-chain-based transistors and sensors, for nanoscale and biological applications.

  3. Crystalline mono- and multilayer self-assemblies of oligothiophenes at the air-water interface

    DEFF Research Database (Denmark)

    Isz, S.; Weissbuch, I.; Kjær, K.

    1997-01-01

    The formation of Langmuir monolayers at the air-water interface has long been believed to be limited to amphiphilic molecules containing a hydrophobic chain and a hydrophilic headgroup. Here we report the formation of crystalline mono- and multilayer self-assemblies of oligothiophenes, a class...... of aromatic nonamphiphilic molecules, self-aggregated at the air-water interface. As model systems we have examined the deposition of quaterthiophene (S-4), quinquethiophene (S-5). and sexithiophene (S-6) from chloroform solutions on the water surface. The structures of the films were determined by surface...... surface. S-5 self-ageregates at the water surface to form mixtures of monolayers and bilayers of the beta polymorph; S-6 forms primarily crystalline monolayers of both alpha and beta forms. The crystalline assemblies preserve their integrity during transfer from the water surface onto solid supports...

  4. Rola nagrań wideo w badaniu ontogenezy mowy w środowisku mono- i bilingwalnym

    Directory of Open Access Journals (Sweden)

    Anna Nallur

    2017-07-01

    Full Text Available The article presents the audio – video techniques that nowadays are the basic tools for the study of the child’s language development. These techniques could be used for mono and bilingual children. The author describes a “language biography” as one of the methods for the acquisition of language competence. According to W. Miodunka (2016, the “language biography” as a research method should include the following characteristics: openness, natural, and excellent communication. These features could be accomplished by using a camera during everyday activities. Additionally, the article presents the principles of recording videos for research purposes that could be valuable information for other studies. Thereafter, the author shows the technique to transcribe recordings based on the language development study of two bilingual and two monolingual children.

  5. Metabolism of UC-labelled urea in conventional, germ-free and mono-associated rats

    Energy Technology Data Exchange (ETDEWEB)

    Juhr, N.C.; Franke, J.

    1987-01-01

    This report deals with the utilization of UC-labelled urea in conventional, defined associated and germ-free rats. With conventional animals 71.44% of the administered UC dose can be demonstrated in the exhaled air, 0.47% in organs and 27.35% in the urine. 1.04% was found in the intestinal and fecal contents. Animals mono-associated with Proteus mirabilis have nearly the same utilization rate (59.15, 0.34, 35.98, 2% resp.). In germ-free animals 1.21% of the activity appeared in the exhaled air and showed a small part of non-enzymatic hydrolysis of urea. The excretion of 97.70% in the urine shows that urea is absorbed from the intestine in germ-free animals.

  6. Mitochondrial membranes with mono- and divalent salt: changes induced by salt ions on structure and dynamics

    DEFF Research Database (Denmark)

    Pöyry, Sanja; Róg, Tomasz; Karttunen, Mikko

    2009-01-01

    We employ atomistic simulations to consider how mono- (NaCl) and divalent (CaCl(2)) salt affects properties of inner and outer membranes of mitochondria. We find that the influence of salt on structural properties is rather minute, only weakly affecting lipid packing, conformational ordering......, and membrane electrostatic potential. The changes induced by salt are more prominent in dynamical properties related to ion binding and formation of ion-lipid complexes and lipid aggregates, as rotational diffusion of lipids is slowed down by ions, especially in the case of CaCl(2). In the same spirit, lateral...... diffusion of lipids is slowed down rather considerably for increasing concentration of CaCl(2). Both findings for dynamic properties can be traced to the binding of ions with lipid head groups and the related changes in interaction patterns in the headgroup region, where the binding of Na(+) and Ca(2+) ions...

  7. Imperfections and phase transformations by mono-N-alkylammonium-uranium glimmers

    International Nuclear Information System (INIS)

    Kammermeier, H.

    1982-01-01

    Uranium glimmers have a layered structure. Bimolecular intermediate layered films of parallel ordered alkyl chains can be produced by exchange of the intermediate layer kations with the mono-n-alkylammonium ions and the succession of soaking with n-alkanols. Phase changes can occur in these films that are accompanied by a change of the layer distance of the solid inorganic basic matrix. N-alkyl ammonium-n-alkanol-intercalcation compounds of uranium glimmers represent systems that can conveniently be examined with X-rays. Thermal phase changes can be performed easily. This paper describes how one can derive conclusions on the reaction mechanism of phase changes in bimolecular alkyl chain films by means of a profile analysis of X-ray reflexes. (orig./HBR) [de

  8. All About ALS

    Science.gov (United States)

    ... Subscribe August 2015 Print this issue All About ALS Understanding a Devastating Disorder En español Send us ... Sports Concussions Wise Choices How Can I Help ALS Research? If you have ALS, join the National ...

  9. E. P. R. spectroscopic study of nitroxide mono- and bi-radicals

    International Nuclear Information System (INIS)

    Lemaire, H.

    1966-09-01

    A nitroxide is a molecule containing the group N-O where the oxygen atom made only one bond instead of the usual two. The main advantage of these radicals is their exceptional stability; this allows the study of well defined chemical structures while varying at will the experimental conditions. Studies by electron paramagnetic resonance of nitroxide mono-radicals have given the principal directions and the principal values of the electron-nitrogen nucleus hyperfine tensor and of the anisotropic g-factor tensor. The results were then related to the electronic structure of radicals. An understanding was obtained of the influence of the solvent on the principal values of the tensors, and the marked differences observed in the broadening of hyperfine lines when the medium become viscous. In the nitroxide biradicals, the hyperfine spectra depends not only on the magnetic interactions relative to each monomer, but also on the magnitude of the exchange interaction between the singlet and the triplet states of the dimer; the biradicals studied here are the first organic compounds which show clearly the influence of this exchange on the hyperfine structure. The two unpaired electrons also interact by a magnetic dipolar interaction: in the intermediate case, this can be used to derive the sign of the exchange interaction if the bi-radical is studied in a liquid crystal. Just as for mono-radicals, the hyperfine spectra of bi-radicals show selective broadening in viscous media, which is caused by an overall motional modulation of the anisotropic tensors. This gives another way to determine the sign of the exchange interaction. (author) [fr

  10. First-principles study on mono-vacancy self diffusion and recovery in tungsten crystal

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Shu long [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Chen, Ji ming; Liu, Xiang [Fusion Science of Southwestern Institute of Physics, Chengdu, Sichuan 610041 (China); Zhu, Hao; Chang, Hong yan [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Huang, Zheng, E-mail: zhhuang@swjtu.edu.cn [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Pan, Min, E-mail: mpan@swjtu.edu.cn [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Western Superconducting Technologies Co., Ltd., Xi’an, Shanxi 710018 (China); Zhao, Yong [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China)

    2016-11-01

    Highlights: • The migration barrier energy E{sub m} of vacancy indicated that the optimum diffusion paths would exist in the diffusion process. • The Frenkel pair’s recovery had a close correlation with the “I–V” distance and within a range of 1.86–2.08 eV. • The self-recovery region has an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. • The probability for the vacancy migration was closely assosiated with the E{sub m} and the working temperature. - Abstract: The point defects behavior becomes one of the most basic issues under the challenge of fusion environment. The recovery mechanisms of Frenkel pair defects and the self-diffusion coefficient of mono-vacancy in bulk bcc tungsten were researched by the first principle calculations. The calculation of migration energy curves for <111> SIAs indicated that the process of the Frenkel pair recovery had a close correlation with the “I–V” distance, and the migration barrier energies E{sub m} was within a limit range of 1.86–2.08 eV. It was found that the self-recovery region had an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. The self-diffusion coefficients of the mono-vacancy were calculated and the results showed that the probability for the vacancy migration was not only associated with the E{sub m} but also the temperature being challenged.

  11. Analysis of Gas Membrane Ultra-High Purification of Small Quantities of Mono-Isotopic Silane

    Energy Technology Data Exchange (ETDEWEB)

    de Almeida, Valmor F [ORNL; Hart, Kevin J [ORNL

    2016-09-01

    A small quantity of high-value, crude, mono-isotopic silane is a prospective gas for a small-scale, high-recovery, ultra-high membrane purification process. This is an unusual application of gas membrane separation for which we provide a comprehensive analysis of a simple purification model. The goal is to develop direct analytic expressions for estimating the feasibility and efficiency of the method, and guide process design; this is only possible for binary mixtures of silane in the dilute limit which is a somewhat realistic case. Among the common impurities in crude silane, methane poses a special membrane separation challenge since it is chemically similar to silane. Other potential problematic surprises are: ethylene, diborane and ethane (in this order). Nevertheless, we demonstrate, theoretically, that a carefully designed membrane system may be able to purify mono-isotopic, crude silane to electronics-grade level in a reasonable amount of time and expenses. We advocate a combination of membrane materials that preferentially reject heavy impurities based on mobility selectivity, and light impurities based on solubility selectivity. We provide estimates for the purification of significant contaminants of interest. To improve the separation selectivity, it is advantageous to use a permeate chamber under vacuum, however this also requires greater control of in-leakage of impurities in the system. In this study, we suggest cellulose acetate and polydimethylsiloxane as examples of membrane materials on the basis of limited permeability data found in the open literature. We provide estimates on the membrane area needed and priming volume of the cell enclosure for fabrication purposes when using the suggested membrane materials. These estimates are largely theoretical in view of the absence of reliable experimental data for the permeability of silane. Last but not least, future extension of this work to the non-dilute limit may apply to the recovery of silane from

  12. Non-cirrhotic portal hypertension in HIV mono-infected patients.

    Science.gov (United States)

    Jackson, Belinda D; Doyle, Joseph S; Hoy, Jennifer F; Roberts, Stuart K; Colman, John; Hellard, Margaret E; Sasadeusz, Joseph J; Iser, David M

    2012-09-01

    Unexplained liver injury including fibrosis and portal hypertension has rarely been reported among patients with HIV in the absence of co-infection with hepatitis B (HBV) or hepatitis C (HCV). We describe a series of HIV mono-infected patients with evidence of non-cirrhotic portal hypertension. HIV-infected patients with evidence of portal hypertension who were anti-HBV and anti-HCV negative and HBV and HCV RNA polymerase chain reaction (PCR) negative were identified from patients managed by the Victorian statewide HIV referral service located at The Alfred Hospital, Melbourne. Portal hypertension was defined as either radiological or endoscopic evidence of varices, portal vein flow obstruction, or elevated hepatic venous pressure gradient (HPVG). Five patients were found to have portal hypertension. These patients were male, aged 41 to 65 years, with known duration of HIV infection between 11 to 25 years. All had been treated with antiretroviral therapy, including didanosine. Tests for metabolic, autoimmune, and hereditary causes of liver disease failed to establish an etiology for the liver injury. All had radiological or endoscopic findings of varices, and four patients had radiological features of portal vein obstruction or flow reversal. Only one patient underwent HPVG measurement, which was elevated. Non-invasive fibrosis assessment revealed increased liver stiffness in three (out of four) patients, and no cirrhotic features were found on those who underwent liver biopsy. To our knowledge, this is the largest published series of non-cirrhotic portal hypertension in HIV mono-infected patients in Australia. Further research is needed to understand what relationship, if any, HIV or its treatments might have on liver injury over time. © 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

  13. Nitrogen fixation dynamics of two diazotrophic communities in Mono Lake, California

    Science.gov (United States)

    Oremland, R.S.

    1990-01-01

    Two types of diazotrophic microbial communities were found in the littoral zone of alkaline hypersaline Mono Lake, California. One consisted of anaerobic bacteria inhabiting the flocculent surface layers of sediments. Nitrogen fixation (acetylene reduction) by flocculent surface layers occurred under anaerobic conditions, was not stimulated by light or by additions of organic substrates, and was inhibited by O2, nitrate, and ammonia. The second community consisted of a ball-shaped association of a filamentous chlorophyte (Ctenocladus circinnatus) with diazotrophic, nonheterocystous cyanobacteria, as well as anaerobic bacteria (Ctenocladus balls). Nitrogen fixation by Ctenocladus balls was usually, but not always, stimulated by light. Rates of anaerobic dark fixation equaled those in the light under air. Fixation in the light was stimulated by 3-(3,4-dichlorophenyl)-1,1-dimethylurea and by propanil [N-(3,4-dichlorophenyl)propanamide]. 3-(3,4-Dichlorophenyl)-1,1-dimethyl urea-elicited nitrogenase activity was inhibited by ammonia (96%) and nitrate (65%). Fixation was greatest when Ctenocladus balls were incubated anaerobically in the light with sulfide. Dark anaerobic fixation was not stimulated by organic substrates in short-term (4-h) incubations, but was in long-term (67-h) ones. Areal estimates of benthic N2 fixation were measured seasonally, using chambers. Highest rates (~29.3 ??mol of C2H4 m-2 h-1) occurred under normal diel regimens of light and dark. These estimates indicate that benthic N2 fixation has the potential to be a significant nitrogen source in Mono Lake.

  14. Prevalence and correlates of cigarette smoking among Chinese schizophrenia inpatients receiving antipsychotic mono-therapy.

    Directory of Open Access Journals (Sweden)

    Yan-Min Xu

    Full Text Available OBJECTIVE: To investigate the prevalence rate of cigarette smoking and its socio-demographic and clinical correlates in Chinese schizophrenia inpatients receiving antipsychotic mono-therapy. METHODS: This study was a cross-sectional, two-site, hospital-based survey. Four hundred and twenty-nine schizophrenia patients (male/female: 66.9% vs. 33.1% were consecutively recruited from psychosis inpatient wards of two large specialty psychiatric hospitals in mainland China. Patients were assessed using a cigarette smoking questionnaire, the Positive and Negative Symptom Scale, the Simpson Angus Scale, the Barnes Akathisia Rating Scale, and the Abnormal Involuntary Movement Scale. Socio-demographic and other clinical data were also collected. We calculated the prevalence of current smoking in our sample as well as its indirectly standardized prevalence ratio (ISPR using data from the 2010 Global Adult Tobacco Survey in China. RESULTS: The prevalence rate of current smoking was 40.6% in our sample, and 57.5% in males and 6.3% in females. The ISPRs of all patients, men and women were 1.11(95%CI: 0.95 ∼ 1.29, 1.07(95%CI = 0.91 ∼ 1.24 and 4.64(95% CI = 2.12 ∼ 8.82, respectively. The overall and male-specific prevalence of current smoking did not differ significantly between patients and the general population. In multiple logistic regression analysis, male sex, older age, poor marital status, alcohol use, use of first-generation antipsychotics, longer duration of illness, more frequent hospitalizations, and more severe negative symptoms were independently associated with current smoking. CONCLUSION: Male Chinese inpatients with schizophrenia who received a mono-therapy of antipsychotics were not more likely to smoke than the general population. Cigarette smoking is more common in schizophrenia patients with more severe illness.

  15. First-principles study on mono-vacancy self diffusion and recovery in tungsten crystal

    International Nuclear Information System (INIS)

    Wen, Shu long; Chen, Ji ming; Liu, Xiang; Zhu, Hao; Chang, Hong yan; Huang, Zheng; Pan, Min; Zhao, Yong

    2016-01-01

    Highlights: • The migration barrier energy E_m of vacancy indicated that the optimum diffusion paths would exist in the diffusion process. • The Frenkel pair’s recovery had a close correlation with the “I–V” distance and within a range of 1.86–2.08 eV. • The self-recovery region has an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. • The probability for the vacancy migration was closely assosiated with the E_m and the working temperature. - Abstract: The point defects behavior becomes one of the most basic issues under the challenge of fusion environment. The recovery mechanisms of Frenkel pair defects and the self-diffusion coefficient of mono-vacancy in bulk bcc tungsten were researched by the first principle calculations. The calculation of migration energy curves for SIAs indicated that the process of the Frenkel pair recovery had a close correlation with the “I–V” distance, and the migration barrier energies E_m was within a limit range of 1.86–2.08 eV. It was found that the self-recovery region had an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. The self-diffusion coefficients of the mono-vacancy were calculated and the results showed that the probability for the vacancy migration was not only associated with the E_m but also the temperature being challenged.

  16. Sedimentary and Volcanic Records of the Laschamp and Mono Lake Excursions from Australia and New Zealand

    Science.gov (United States)

    Ingham, E. M.; Roberts, A. P.; Turner, G. M.; Heslop, D.; Ronge, T.; Conway, C.; Leonard, G.; Townsend, D.; Tiedemann, R.; Lamy, F.; Calvert, A. T.

    2014-12-01

    Geomagnetic excursions are short-lived deviations of the geomagnetic field from the normal range of secular variation. Despite significant advances in geomagnetic excursion research over the past 20 years, fundamental questions remain concerning the typical duration and global morphology of excursional geomagnetic fields. To answer such questions, more high-resolution, chronologically well-constrained excursion records are required, particularly from the Southern Hemisphere. We present preliminary paleomagnetic records of the Laschamp (~41 ka) and Mono Lake (~35 ka) excursions from three marine sediment cores from the Bounty Trough, New Zealand margin, and complementary volcanic records of the Laschamp excursion from lavas of Mt Ruapehu, New Zealand. Relatively high sedimentation rates of 12 - 26 cm/kyr in the Bounty Trough during glacial periods allow identification of excursional field behavior at each of the studied core locations. Each core displays one or two excursional events, with rapid directional swings between stable normal polarity and reversed excursional directions, each associated with coincident relative paleointensity minima. These anomalous paleomagnetic directions are interpreted to represent the Laschamp and Mono Lake excursions, based on a combination of tephrochronology, radiocarbon dating, and cyclostratigraphy (defined from core-scanning X-ray fluorescence and magnetic susceptibility records). Beside these records, we present results from fourteen lava flows, on Mt Ruapehu, for which 40Ar-39Ar dating indicates ages of between 39 and 45 ka. The step heating 40Ar-39Ar experiments produced particularly flat age plateaus, with corresponding 2 s.d. errors mostly approaching 1 kyr. The youngest and oldest flows carry normal polarity magnetization, however six flows, dated between 41 and 43 ka, display transitional field characteristics. Three of these flows display a declination swing of around 180o, which coincides with a previously published

  17. Differences in Classification Between Mono- and Polytrauma and Low- and High-Energy Trauma Patients With an Ankle Fracture : A Retrospective Cohort Study

    NARCIS (Netherlands)

    Briet, Jan Paul; Houwert, Roderick Marijn; Smeeing, Diederik P J; Dijkgraaf, Marcel G. W.; Verleisdonk, Egbert Jan M M; Leenen, Luke P H; Hietbrink, Falco

    2017-01-01

    Although fracture type and treatment options for ankle fractures are well defined, the differences between mono- and polytrauma patients and low- and high-energy trauma have not been addressed. The aim of the present study was to compare the fracture type and trauma mechanism between mono- and

  18. Differences in Classification Between Mono- and Polytrauma and Low- and High-Energy Trauma Patients With an Ankle Fracture: A Retrospective Cohort Study

    NARCIS (Netherlands)

    Briet, Jan Paul; Houwert, Roderick Marijn; Smeeing, Diederik P. J.; Dijkgraaf, Marcel G. W.; Verleisdonk, Egbert Jan; Leenen, Luke P. H.; Hietbrink, Falco

    2017-01-01

    Although fracture type and treatment options for ankle fractures are well defined, the differences between mono- and polytrauma patients and low- and high-energy trauma have not been addressed. The aim of the present study was to compare the fracture type and trauma mechanism between mono- and

  19. 21 CFR 582.4101 - Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4101 Section 582.4101 Food and... Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat-forming fatty acids. (a) Product. Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or...

  20. Sources of SOA gaseous precursors in contrasted urban environments: a focus on mono-aromatic compounds and intermediate volatility compounds

    Science.gov (United States)

    Salameh, Therese; Borbon, Agnès; Ait-Helal, Warda; Afif, Charbel; Sauvage, Stéphane; Locoge, Nadine; Bonneau, Stéphane; Sanchez, Olivier

    2016-04-01

    Among Volatile Organic Compounds (VOC), the mono-aromatic compounds so-called BTEX (Benzene, Toluene, Ethylbenzene, and Xylenes) and the intermediate volatility organic compounds (IVOC) with C>12 are two remarkable chemical families having high impact on health, as well as on the production of secondary pollutants like secondary organic aerosols (SOA) and ozone. However, the nature and relative importance of their sources and, consequently, their impact on SOA formation at urban scale is still under debate. On the one hand, BTEX observations in urban areas of northern mid-latitudes do not reconcile with emission inventories; the latter pointing to solvent use as the dominant source compared to traffic. Moreover, a recent study by Borbon et al. (2013) has shown an enrichment in the C7-C9 aromatic fraction in Paris atmosphere by a factor of 3 compared to other cities. Causes would be: (i) differences in gasoline composition, (ii) differences in vehicle fleet composition, and (iii) differences in solvent use related sources. On the other hand, many smog chamber studies have highlighted IVOCs as important SOA precursors over the last decade but their origin and importance in urban areas relative to other precursors like BTEX is still poorly addressed. Here we combined large VOC datasets to investigate sources of BTEX and IVOC in contrasted urban areas by source-receptor approaches and laboratory experiments. Ambient data include multi-site speciated ambient measurements of C2 to C17 VOCs (traffic, urban background, and tunnel) from air quality networks (ie. AIRPARIF in Paris) and intensive field campaigns (MEGAPOLI-Paris, TRANSEMED in Beirut and Istanbul, PHOTOPAQ in Brussels). Preliminary results for Paris suggest that traffic dominates BTEX concentrations while traffic and domestic heating for IVOC (>70%). In parallel, the detailed composition of the fuel liquid phase was determined at the laboratory for typical fuels distributed in Ile de France region (diesel, SP95

  1. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

    Energy Technology Data Exchange (ETDEWEB)

    Craig, Zelieann R., E-mail: zelieann@illinois.edu; Hannon, Patrick R., E-mail: phannon2@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2013-11-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P{sub 4}) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P{sub 4}, androstenedione (A), testosterone (T), estrone (E{sub 1}), and 17β-estradiol (E{sub 2}) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E{sub 2}. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P{sub 4}, A, T, and E{sub 1} that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis

  2. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

    International Nuclear Information System (INIS)

    Craig, Zelieann R.; Hannon, Patrick R.; Flaws, Jodi A.

    2013-01-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P 4 ) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P 4 , androstenedione (A), testosterone (T), estrone (E 1 ), and 17β-estradiol (E 2 ) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E 2 . Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P 4 , A, T, and E 1 that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis in mono-OH MXC

  3. Self-construing in children with primary mono-symptomatic nocturnal enuresis--an investigation of three measures.

    Science.gov (United States)

    Robinson, Joanne C; Butler, Richard J; Holland, Philip; Doherty-Williams, Dianne

    2003-01-01

    This study aims to measure different aspects of self-construing in children with primary mono-symptomatic nocturnal enuresis. 25 children aged 7-14 years, with nocturnal enuresis were recruited from a paediatric outpatient's unit specialising in enuresis [mean age 10.6 [males], 9.39 [females

  4. On Hydrogen Bonding in the Intramolecularly Chelated Taitomers of Enolic Malondialdehyde and its Mono- and Dithio-Analogues

    DEFF Research Database (Denmark)

    Carlsen, Lars; Duus, Fritz

    1980-01-01

    The intramolecular hydrogen bondings in enolic malondialdehyde and it mono- and dithio-analogues have been evaluated by a semiempricial SCF–MO–CNDO method. The calculations predict that the hydrogen bonds play an important part in the stabilities of malondialdehyde and monothiomalondialdehyde...

  5. [Detection of fps tumor antigen with mono-specific anti-fps serum in tumors induced by acute transforming ALV].

    Science.gov (United States)

    Wang, Yixin; Chen, Hao; Zhao, Peng; Li, Jianliang; Cui, Zhizhong

    2013-03-04

    To prepare anti-fps mono-specific serum, and detect the fps antigen in tumors induced by acute transforming avian leukosis/sarcoma virus containing v-fps oncogene. Two part of v-fps gene was amplified by RT-PCR using the Fu-J viral RNA as the template. Mono-specific serum was prepared by immuning Kunming white mouse with both two recombinant infusion proteins expressed by the prokaryotic expression system. Indirect immunofluorescent assay was used to detect fps antigen in tumor tissue suspension cells and CEF infected by sarcoma supernatant. Immunohistochemical method was used to detect fps antigen in tumor tissue. The mouse mono-specific serum was specific as it had no cross reaction with classical ALV-J strains. The result reveals that the tumor tissue suspension cells, the CEF infected by sarcoma supernatant, and the slice immunohistochemistry of the sarcoma showed positive results. The anti-fps mono-specific serum was prepared, and the detection method was established, which laid the foundation for the study of viral biological characteristics and mechanism of tumourgenesis of acute transforming avian leukosis/sarcoma virus containing v-fps oncogene.

  6. Dynamics of polyelectrolyte adsorption and colloidal flocculation upon mixing studied using mono-dispersed polystyrene latex particles

    NARCIS (Netherlands)

    Feng, Lili; Cohen Stuart, Martien; Adachi, Yasuhisa

    2015-01-01

    The dynamic behavior of polyelectrolytes just after their encounter with the surface of bare colloidal particles is analyzed, using the flocculation properties of mono-dispersed polystyrene latex (PSL) particles. Applying a Standardized Colloid Mixing (SCM) approach, effects of ionic strength and

  7. The use of approximation formulae in calculations of acid-base equilibria-II: salts of mono- and diprotic acids.

    Science.gov (United States)

    Narasaki, H

    1980-02-01

    The pH of solutions of salts of mono- and diprotic acids is calculated by use of approximation formulae and the theoretically exact equations. The regions for useful application of the approximation formulae (error monoprotic acids, areas are symmetrically equal to those of the acids. For salts of diprotic acids the ranges generally depend on K(2)/K(1).

  8. Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides.

    Science.gov (United States)

    Sakamoto, Ryu; Sakurai, Shunya; Maruoka, Keiji

    2017-06-13

    The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.

  9. An unusual mono-substituted Keggin anion-chain based 3D framework with 24-membered macrocycles as linker units

    International Nuclear Information System (INIS)

    Pang Haijun; Ma Huiyuan; Yu Yan; Yang Ming; Xun Ye; Liu Bo

    2012-01-01

    A new compound, [Cu I (H 2 O)(Hbpp) 2 ]⊂{[Cu I (bpp)] 2 [PW 11 Cu II O 39 ]} (1) (bpp=1,3-bis(4-pyridyl)propane), has been hydrothermally synthesized and structurally characterized by single crystal X-ray diffraction. In compound 1, the unusual –A–B–A–B– array mono-substituted Keggin anion-chains and 24-membered (Cubpp) 2 cation-macrocycles are linked together to form a (2, 4) connected 3D framework with channels of ca. 9.784×7.771 Å 2 along two directions, in which the [Cu(H 2 O)(Hbpp) 2 ] coordination fragments as guest components are trapped. The photocatalytic experiments of compound 1 were performed, which show a good catalytic activity of compound 1 for photodegradation of RhB. Furthermore, the IR, TGA and electrochemical properties of compound 1 were investigated. - Graphical abstract: An unusual example of mono-substituted Keggin anion-chain based hybrid compound that possesses a 3D structure has been synthesized, which offers a feasible route for synthesis of such compounds. Highlights: ► The first example of –A–B–A–B– array mono-substituted Keggin chain is observed. ► An unusual three dimensional structure based mono-substituted Keggin anion-chains. ► The photocatalysis and electrochemical properties of the title compound were studied.

  10. 21 CFR 582.4521 - Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4521 Section 582.4521 Food and... Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat-forming... oils, or edible fat-forming fatty acids. (b) Conditions of use. This substance is generally recognized...

  11. 40 CFR 721.3130 - Sulfuric acid, mono-C9-11-alkyl esters, sodium salts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sulfuric acid, mono-C9-11-alkyl esters, sodium salts. 721.3130 Section 721.3130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... significant new uses are: (i) Industrial, commercial, and consumer activities. Requirements as specified in...

  12. A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

    NARCIS (Netherlands)

    Cankar, K.; van Houwelingen, A.; Bosch, H.J.; Sonke, T.; Bouwmeester, H.; Beekwilder, J.P.

    2011-01-01

    Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene

  13. MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate

    Directory of Open Access Journals (Sweden)

    Erich K. Odermatt

    2012-01-01

    Full Text Available A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strength in vivo and is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ has no residual strength in vivo after 12 weeks. In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication.

  14. Organic geochemistry and brine composition in Great Salt, Mono, and Walker Lakes

    Science.gov (United States)

    Domagalski, Joseph L.; Orem, W.H.; Eugster, H.P.

    1989-01-01

    Samples of Recent sediments, representing up to 1000 years of accumulation, were collected from three closed basin lakes (Mono Lake, CA, Walker Lake, NV, and Great Salt Lake, UT) to assess the effects of brine composition on the accumulation of total organic carbon, the concentration of dissolved organic carbon, humic acid structure and diagenesis, and trace metal complexation. The Great Salt Lake water column is a stratified Na-Mg-Cl-SO4 brine with low alkalinity. Algal debris is entrained in the high density (1.132-1.190 g/cc) bottom brines, and in this region maximum organic matter decomposition occurs by anaerobic processes, with sulfate ion as the terminal electron acceptor. Organic matter, below 5 cm of the sediment-water interface, degrades at a very slow rate in spite of very high pore-fluid sulfate levels. The organic carbon concentration stabilizes at 1.1 wt%. Mono Lake is an alkaline (Na-CO3-Cl-SO4) system. The water column is stratified, but the bottom brines are of lower density relative to the Great Salt Lake, and sedimentation of algal debris is rapid. Depletion of pore-fluid sulfate, near l m of core, results in a much higher accumulation of organic carbon, approximately 6 wt%. Walker Lake is also an alkaline system. The water column is not stratified, and decomposition of organic matter occurs by aerobic processes at the sediment-water interface and by anaerobic processes below. Total organic carbon and dissolved organic carbon concentrations in Walker Lake sediments vary with location and depth due to changes in input and pore-fluid sulfate concentrations. Nuclear magnetic resonance studies (13C) of humic substances and dissolved organic carbon provide information on the source of the Recent sedimentary organic carbon (aquatic vs. terrestrial), its relative state of decomposition, and its chemical structure. The spectra suggest an algal origin with little terrestrial signature at all three lakes. This is indicated by the ratio of aliphatic to

  15. Preliminary Paleomagnetic Data From Santa Mariá Volcano, Guatemala and Their Bearing on the Mono Lake and Hilina Pali Excursions

    Science.gov (United States)

    Escobar Wolf, R. P.; Diehl, J. F.; Rose, W. I.; Singer, B. S.

    2005-12-01

    Paleomagnetic directions determined from oriented block samples collected by Rose et al. in 1977 ( Journal of Geology) and from eight paleomagnetic sites drilled in lava flows from Santa Maria volcano, Guatemala in 1990 define a pattern of variation similar to the pattern of geomagnetic field changes recorded by the sediments of the Wilson Creek Formation near Mono Lake, California. This led Conway et al. in 1994 ( Journal of Geology) to suggest that these flows had recorded the Mono Lake Excursion (MLE). The correlation was made on pattern recognition alone and relied almost entirely the well- defined inclination dataset than on the declination data; no radioisotopic ages were available. In March of 2005 we returned to the crater of Santa Mariá and drilled 23 lava flows from the original sections of Rose et al; block samples for 40Ar/39Ar were also collected. Unfortunately aggradation in the crater due to mass wasting made it impossible to sample all the flows of Rose et al. At each site or lava flow, four to seven cores were drilled and oriented with a sun compass. Samples cut from the drilled cores were magnetically cleaned using alternation field demagnetization and analyzed using principle component analysis. Thermal demagnetization is currently underway. The resulting inclination waveform (over 70° of change from +60° to -12°) is very similar to those previously reported in the literature for the MLE, but the declination waveform shows little variation (<25°; mean declination is 13.4°) throughout the stratigraphic sequence that we collected. Consequently, VGP data from the lava flows do not show the classic clockwise and counterclockwise loops as seen at the Wilson Creek section and at other MLE locations. Instead the directions (VGPs) tend to cluster in three distinct groups with the lowermost lava flows (5) and uppermost lava flows (3) clustering near the expected axial dipole inclination for the region (~28 °) while lava flows from the middle of the

  16. Efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I Effects of greater-than-5% weight reduction on hemodynamic, metabolic and neuroendocrine profiles of grade I obese subjects

    Directory of Open Access Journals (Sweden)

    Kelly Biancardini Gomes Barbato

    2006-07-01

    Full Text Available OBJETIVO: Avaliar os efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I. MÉTODOS: Estudo observacional com 47 obesos grau I, média de idade de 33 anos, submetidos a orientação mensal quanto a dieta, exercício físico e comportamento alimentar, durante quatro meses. A pressão arterial, pelo método auscultatório, e a freqüência cardíaca, pelo método palpatório, foram avaliadas mensalmente, enquanto as seguintes variáveis (e respectivos métodos foram medidas no início e final do estudo: colesterol total, triglicerídeos, HDL-colesterol (enzimático, LDL-colesterol (fórmula de Friedwald, glicemia (enzimático hexoquinase, leptina, adiponectina, renina, aldosterona, insulina (radioimunoensaio e índice de resistência à insulina (HOMA. RESULTADOS: Observamos, após ajuste para outras variáveis, reduções significativas de 6 mmHg na pressão arterial diastólica, 7 pg/ml na renina, 13 mg/dl no colesterol total e 12 mg/dl no LDL-colesterol, no grupo com redução de peso superior a 5%. Notamos, também nesse grupo, tendência ao aumento de maior magnitude da adiponectina ao final do estudo, bem como diminuição três vezes maior dos níveis de glicemia, insulina e HOMA, e seis vezes maior da leptina. CONCLUSÃO: Medidas não-farmacológicas capazes de promover redução de peso superior a 5% produzem efeitos hemodinâmicos, metabólicos e neuroendócrinos que melhoram o risco cardiovascular de obesos.OBJECTIVE: To evaluate the effects of a greater-than-5% weight reduction in hemodynamic, metabolic, and neuroendocrine profiles of grade I obese subjects. METHODS: Observational study with 47 grade I obese subjects, with mean age of 33 years who received monthly orientation regarding diet, physical exercises, and eating behavior for four months. Blood pressure using the auscultatory method and pulse rate were assessed monthly, whereas the following variables (and

  17. Oxygen vacancies in oxides studied by annihilation of mono-energetic positrons

    Energy Technology Data Exchange (ETDEWEB)

    Hugenschmidt, Christoph; Pikart, Philip [ZWE FRM II, Technische Universitaet Muenchen, Lichtenbergstrasse 1, 85747 Garching (Germany); Physik-Department E21, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany); Schreckenbach, Klaus [Physik-Department E21, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany)

    2009-07-01

    Oxygen vacancies play a fundamental role for the material properties of various oxides, e.g. charge carrier density in high-Tc superconductors, magnetic properties of diluted magnetic semiconductors or paramagnetic properties of SiO{sub 2}. In this study, open volume defects in (metal) oxides are investigated by Doppler-broadening spectroscopy (DBS) of the positron annihilation. More detailed information about the chemical surrounding at the positron annihilation site is gained by additional coincident DBS experiments, where a signature of positrons annihilating with electrons from oxygen is observed. The mono-energetic positron beam at NEPOMUC was used which allows depth dependent measurements, and hence the investigation of thin oxide layers. Recent results for metallic oxides such as ZnO are presented and compared with various non-metallic oxides such as amorphous and crystalline SiO{sub 2}, oxygen terminated Si-surface, and ice. The role of neutral and charged oxygen vacancies and the application of the positron annihilation technique to study oxygen vacancies will be discussed.

  18. Chemical Composition and Biological Activities of Mono- and Heterofloral Bee Pollen of Different Geographical Origins

    Directory of Open Access Journals (Sweden)

    Jucilene Silva Araújo

    2017-04-01

    Full Text Available Recent research shows variations in pollen chemical constituents and, consequently, in their therapeutic properties. Mono and multifloral bee pollen extracts were investigated for antioxidant and enzyme inhibitory activity properties, phenolic compounds and fatty acid composition. Generally, Eucalyptus spp. and multifloral extracts exhibited potent inhibitory activity against α-amylase, acetylcholinesterase, tyrosinase, lipoxygenase, lipase and hyaluronidase. On the other hand, Miconia spp. demonstrated higher antihemolytic activity. Cocos nucifera and Miconia spp. extracts exhibited important antioxidant properties in the different assays (ABTS, DPPH, β-carotene/linoleic acid and reducing power. Moreover, these extracts had greater amounts of total phenols and flavonoids in comparison to others. The increase in antioxidant activity (decrease in EC50 values was accompanied by an increase in the amount of total phenols in the extracts. The pollen extracts contained linoleic acid and α-linolenic acid as major fatty acids, followed by palmitic acid, and oleic acid. In this study, differences were observed in both chemical constituents and biological activities of the samples related to the geographical and botanical origin of bee pollen.

  19. Purification and crystallization of mono-ubiquitylated ubiquitin receptor Rpn10

    International Nuclear Information System (INIS)

    Keren-Kaplan, Tal; Prag, Gali

    2012-01-01

    A novel reconstitution system for the modification and purification of ubiquitylated proteins yielded the first diffracting crystals of a ubiquitylated substrate, namely Rpn10. Protein ubiquitylation controls nearly all cellular pathways in eukaryotes. A repertoire of proteins named ubiquitin (Ub) receptors harbouring ubiquitin-binding domains (UBDs) recognize ubiquitylated proteins. These Ub receptors decode the Ub signal by tethering a UBD or UBDs to a functional domain or domains, thus linking the ubiquitylated target to a specific function. The rapid dynamics of ubiquitylation/deubiquitylation has impeded the characterization of ubiquitylated proteins. To bypass this obstacle, a recently developed synthetic system that reconstructs the entire eukaryotic ubiquitylation cascade in Escherichia coli was used to purify the mono-ubiquitylated form of the regulatory proteasomal non-ATPase subunit (Ub-Rpn10) from Saccharomyces cerevisiae. Here, the first crystallization and data collection of Ub-Rpn10 is reported. Purified Ub-Rpn10 was crystallized in 12%(w/v) PEG 20 000, 0.1 M MES pH 6.5 and yielded thin rhombus-shaped crystals. X-ray analysis revealed that these crystals belonged to the monoclinic system C2, with unit-cell parameters a = 107.3, b = 49.7, c = 81.3 Å, α = γ = 90.0, β = 130.5°. A full synchrotron data set has been collected, merged and scaled with a diffraction limit of 3.14 Å

  20. Seasonal variation of mono- and sesquiterpenoid components in the essential oil of Dracocephalum kotschyi Boiss.

    Directory of Open Access Journals (Sweden)

    G. Asghari

    2014-10-01

    Full Text Available Background and objectives: Dracocephalum kotschyi is a plant which belongs to the Lamiaceae family and exists mostly in south-west Asian countries, including Iran. This plant is used as antispasmodic, analgesic and anti-inflammatory to treat rheumatoid diseases. Methods: In order to investigate the impact of the harvesting time changes on the quantity and quality of mono- and sesquiterpenoid components of D. kotschyi aerial parts, ten samples were collected from cultivated plants from 19 April to 27 August 2013. Also samples of flower and root were harvested in order to investigate their essential oil components. The essential oils were obtained through hydrodistillation method. The components were studied and identified by GC and GC ⁄ MS systems. Results: The highest yield of the essential oil was obtained on 3 May (1.10% V.W and the lowest on 28 July (0.29% V.W. Totally 55 compounds were identified in the essential oil while the highest percentage belonged to monoterpenes especially the oxygenated ones. Most variations were observed in geraniol (1.40-15.34%, geranyl acetate (trace-14.41% and neryl acetate (0.62-17.51%. The major value in most cases belonged to geranial. Conclusion: the results of this study indicate that the harvesting time of plant is an effective factor in the quality and quantity of theessential oil of Dracocephalum kotschyi.

  1. Mono-, di- and trinuclear dioxo complexes of uranium containing hydrazonato and azomethine ligands

    International Nuclear Information System (INIS)

    Gatto, C.C.; Schulz Lang, E.

    2004-01-01

    Mono-, di or trinuclear dioxouranium complexes with benzoylhydrazonato or azomethine ligands were prepared by reactions of common dioxouranium precursors such as UO 2 (NO 3 ) 2 . 6 H 2 O or [NBu 4 ] 2 [UO 2 Cl 4 ] with vanillin benzoylhydrazone (H 2 L 4 ), salicylaldehyde benzoylhydrazone (H 2 L 5 ), 2-hydroxyacetylbenzene salicylhydrazone (H 3 L 6 ) or N-(2-ethoxycarbonyl-3-oxo-but-1-en(1)yl)-2-aminophenol (H 2 L 7 ). Spectroscopic and X-ray crystallographic studies on the complexes [NBu 4 ] 2 [UO 2 Cl 4 ] . 2 H 2 L 4 , [UO 2 (HL 5 )(H 2 L 5 ) 2 ](NO 3 ), [HNEt 3 ] 2 [{UO 2 (L 6 )} 2 ] and [HNEt 3 ] 2 [{UO 2 (L 7 } 3 O)] confirm that the individual donor atom constellation, the size of the potential chelate rings and the acidity of the OH and NH functionalities of the proligands have a strong influence on the structure of the products. (Abstract Copyright [2004], Wiley Periodicals, Inc.) [de

  2. [The discrimination of mono-syllable words in noise in listeners with normal hearing].

    Science.gov (United States)

    Yoshida, M; Sagara, T; Nagano, M; Korenaga, K; Makishima, K

    1992-02-01

    The discrimination of mono-syllable words (67S word-list) pronounced by a male and a female speaker was investigated in noise in 39 normal hearing subjects. The subjects listened to the test words at a constant level of 62 dB together with white or weighted noise in four S/N conditions. By processing the data with logit transformation, S/N-discrimination curves were presumed for each combination of a speech material and a noise. Regardless of the type of noise, the discrimination scores for the female voice started to decrease gradually at a S/N ratio of +10 dB, and reached 10 to 20% at-10 dB. For the male voice in white noise, the discrimination curve was similar to those for the female voice. On the contrary, the discrimination score for the male voice in weighted noise declined rapidly from a S/N ratio of +5 dB, and went below 10% at -5 dB. The discrimination curves seem to be shaped by the interrelations between the spectrum of the speech material and that of the noise.

  3. Comparison of Mono-, Bi-, and Tripolar Configurations for Stimulation and Recording With an Interfascicular Interface.

    Science.gov (United States)

    Nielsen, Thomas N; Sevcencu, Cristian; Struijk, Johannes J

    2014-01-01

    Previous studies have indicated that electrodes placed between fascicles can provide nerve recruitment with high topological selectivity if the areas of interest in the nerve are separated with passive elements. In this study, we investigated if this separation of fascicles also can provide topologically selective nerve recordings and compared the performance of mono-, bi-, and tripolar configurations for stimulation and recording with an intra-neural interface. The interface was implanted in the sciatic nerve of 10 rabbits and achieved a median selectivity of Ŝ=0.98-0.99 for all stimulation configurations, while recording selectivity configurations was in the range of Ŝ=0.70-0.80 with the monopolar configuration providing the lowest and the average reference configuration the highest recording selectivity. Interfascicular electrodes could provide an interesting addition to the bulk of peripheral nerve interfaces available for neural prosthetic devices. The separation of the nerve into chambers by the passive elements of the electrode could ensure a higher selectivity than comparable cuff electrodes and the intra-neural location could provide an option of targeting mainly central fascicles. Further studies are, however, still required to develop biocompatible electrodes and test their stability and safety in chronic experiments.

  4. A prediction model for the effective thermal conductivity of mono-sized pebble beds

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaoliang; Zheng, Jie; Chen, Hongli, E-mail: hlchen1@ustc.edu.cn

    2016-02-15

    Highlights: • One new method to couple the contact area with bed strain is developed. • The constant coefficient to correlate the effect of gas flow is determined. • This model is valid for various cases, and its advantages are showed obviously. - Abstract: A model is presented here to predict the effective thermal conductivity of porous medium packed with mono-sized spherical pebbles, and it is valid when pebbles’ size is far less than the characteristic length of porous medium just like the fusion pebble beds. In this model, the influences of parameters such as properties of pebble and gas materials, bed porosity, pebble size, gas flow, contact area, thermal radiation, contact resistance, etc. are all taken into account, and one method to couple the contact areas with bed strains is also developed and implemented preliminarily. Compared with available theoretical models, CFD numerical simulations and experimental data, this model is verified to be successful to forecast the bed effective thermal conductivity in various cases and its advantages are also showed obviously. Especially, the convection in pebble beds is focused on and a constant coefficient C to correlate the effect of gas flow is determined for the fully developed region of beds by numerical simulation, which is close to some experimental data.

  5. First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent

    International Nuclear Information System (INIS)

    Ni, Yicheng; Chen, Feng; Marchal, Guy; Huyghe, Dieter; Verbeke, Kristin; Verbruggen, Alfons M.; Bormans, Guy M.; Witte, Peter A. de; Nuyts, Johan; Mortelmans, Luc

    2006-01-01

    We have labelled hypericin, a polyphenolic polycyclic quinone found in St. John's wort (Hypericum perforatum), with 123 I and evaluated mono-[ 123 I]iodohypericin (MIH) as a potential necrosis-avid diagnostic tracer agent. MIH was prepared by an electrophilic radioiodination method. The new tracer agent was evaluated in animal models of liver infarction in the rat and heart infarction in the rabbit using single-photon emission computed tomography (SPECT), triphenyltetrazolium chloride (TTC) histochemical staining, serial sectional autoradiography and microscopy, and radioactivity counting techniques. Using in vivo SPECT imaging, hepatic and cardiac infarctions were persistently visualised as well-defined hot spots over 48 h. Preferential uptake of the tracer agent in necrotic tissue was confirmed by perfect match of images from post-mortem TTC staining, autoradiography (ARX) and histology. Radioactivity concentration in infarcted tissues was over 10 times (liver; 3.51% ID/g in necrotic tissue vs 0.38% ID/g in normal tissue at 60 h p.i.) and over 6 times (myocardium; 0.36% ID/g in necrotic tissue vs 0.054% ID/g in normal tissue; ratios up to 18 for selected parts on ARX images) higher than in normal tissues. The results suggest that hypericin derivatives may serve as powerful necrosis-avid diagnostic agents for assessment of tissue viability. (orig.)

  6. Design and syntheses of mono and multivalent mannosyl-lipoconjugates for targeted liposomal drug delivery.

    Science.gov (United States)

    Štimac, Adela; Cvitaš, Jelena TrmĿiĿ; Frkanec, Leo; Vugrek, Oliver; Frkanec, Ruža

    2016-09-10

    Multivalent mannosyl-lipoconjugates may be of interest for glycosylation of liposomes and targeted drug delivery because the mannose specifically binds to C-type lectin receptors on the particular cells. In this paper syntheses of two types of novel O-mannosides are presented. Conjugates 1 and 2 with a COOH- and NH2-functionalized spacer and the connection to a lysine and FmocNH-PEG-COOH, are described. The coupling reactions of prepared intermediates 6 and 4 with a PEGylated-DSPE or palmitic acid, respectively, are presented. Compounds 5, mono-, 8, di- and 12, tetravalent mannosyl-lipoconjugates, were synthesized. The synthesized compounds were incorporated into liposomes and liposomal preparations featuring exposed mannose units were characterized. Carbohydrate liposomal quartz crystal microbalance based assay has been established for studying carbohydrate-lectin binding. It was demonstrated that liposomes with incorporated mannosyl-lipoconjugates were effectively recognized by Con A and have great potential to be used for targeted liposomal drug delivery systems. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Nigeria’s Mono-Cultural Economy: Impact Assessment and Prospects

    Directory of Open Access Journals (Sweden)

    Victor Nwaoba ITUMO

    2016-12-01

    Full Text Available The article takes an insight into the nature of the oil based mono-cultural economy of Nigeria, providing an in-depth analysis of the situation. It clearly assesses the oil resource based economy, highlights the impacts- positive and negative on Nigeria’s economic development and why Nigeria urgently needs to diversify its economy away from oil resource dependence. If Nigeria will not change the oil dependency economy, there will be grave implications for its economic growth and development as it already negatively affects annual budgetary provisions and other fiscal responsibilities. As it is well known, Nigeria is one of the foremost countries in the global oil export, with disruptions in its supply affecting the international oil market in some ways, huge reliance on oil as a resource has seen one of the foremost economies in Africa challenged in her economic growth and development with oil price volatility and decline on the global market. The research made use of secondary data to assess the situation and also drew the conclusion that Nigeria needs to diversify her economy as reliance on a basic resource discourages growth.

  8. Synthesis of mono and multidomain YIG particles by chemical coprecipitation or ceramic procedure

    International Nuclear Information System (INIS)

    Fernandez-Garcia, L.; Suarez, M.; Menendez, J.L.

    2010-01-01

    Yttrium iron garnet powders have been synthesized by chemical coprecipitation using two different precursors, nitrates and chlorides, and by an oxides mixture route. It is shown that depending on the precursors and synthesis conditions used pure yttrium iron garnet powders can be obtained with a mono or multidomain magnetic behaviour. The yttrium iron garnet crystalline structure, as studied by Raman spectroscopy, was already formed after calcination at temperatures as low as 800 o C when the nitrate precursors were used. However, calcination temperatures of up to 1100 o C were required to obtain yttrium iron garnet powders when the precursors were chlorides or when the oxides mixture route was chosen. The saturation magnetization of the powders correlates well with the structural characterization: when nitrate precursors were used, the saturation magnetization was already close to the bulk value, 26.8 emu/cm 3 , after calcination at 800 o C. However, the saturation magnetization of the powders obtained by the chlorides and oxides mixture routes was close to zero up to calcination temperatures of 1100 o C. Finally, both the chlorides and the oxides mixture routes yield multidomain micron sized yttrium iron garnet powders, whereas the nitrates route led to monodomain submicron sized powders.

  9. Mono- and polyadducts of C60 with anthracenes by Diels-Alder-reactions

    International Nuclear Information System (INIS)

    Duarte-Ruiz, A.

    2000-09-01

    This work describes the synthesis and characterization of seven new mono-adducts of 9-methylanthracene, 9,10-dimethylanthracene, 9-bromoanthracene. 2,3,6,7-tetramethylanthracene, 1-methylanthracene, 2,6-di-tert-butylanthracen, as well as 2-methylanthracene to fullerene C60 in solution at r.t. by means of [4+2] Diels-Alder reactions. It could be shown that the mono-adducts with 9-methylanthracene, 9,10-dimethylanthracene, and 1-methylanthracene form the corresponding antipodal bis-adduct 'trans-1' on heating the solid to 180 o C. Furthermore the functionalization of fullerene C60 anthracene mono-adduct (C60C14H10) with anthracene through [4+2] Diels-Alder reactions was investigated which made it possible to separate and to characterize the five possible bis-adducts ('trans-1', 'trans-2', 'trans-3', 'trans-4', and 'e') that can form when the second anthracene adds either 'trans' to the opposite hemisphere (compared to the first addition of anthracene) or to an equatorial position. An exact identification of the bis-adducts 'trans-2' and 'trans-4' could only be acquired with spectroscopic methods, fortunately the bis-adducts 'trans-4', 'trans-3', and 'e' could also be examined by x-ray, thus all five could be fully characterized. No bis-adducts on the same hemisphere ('cis') were found. UV/VIS-spectra of the bis-adducts opened up the possibility to identify other [4+2] Diels-Alder products in the future. It has been noticed that the eluation sequence of the bis-adducts ('trans-1' before 'trans-2' before 'trans-4' before 'trans-3' before 'e') doesn't strictly correlate with the dipole moments. Furthermore six new tris-adducts ('t4t4t2', 't3t3t3', 't3t3t4', 'et3t2', 'et3t4', and 'eee') and one tetra-adduct ('eeet3') were separated and characterized. The tris-adduct 't3t3t3' was additionally characterized by x-ray which showed that the crystal contains only one enatiomer. All bis- and tris-adducts form the antipodal bis-adduct 'trans-1' on heating to 180 o C for 10 min

  10. Glass-liquid-glass reentrance in mono-component colloidal dispersions

    International Nuclear Information System (INIS)

    Ramirez-Gonzalez, P E; Medina-Noyola, M; Vizcarra-Rendon, A; Guevara-Rodriguez, F de J

    2008-01-01

    The self-consistent generalized Langevin equation (SCGLE) theory of colloid dynamics is employed to describe the ergodic-non-ergodic transition in model mono-disperse colloidal dispersions whose particles interact through hard-sphere plus short-ranged attractive forces. The ergodic-non-ergodic phase diagram in the temperature-concentration state space is determined for the hard-sphere plus attractive Yukawa model within the mean spherical approximation for the static structure factor by solving a remarkably simple equation for the localization length of the colloidal particles. Finite real values of this property signals non-ergodicity and determines the non-ergodic parameters f(k) and f s (k). The resulting phase diagram for this system, which involves the existence of reentrant (repulsive and attractive) glass states, is compared with the corresponding prediction of mode coupling theory. Although both theories coincide in the general features of this phase diagram, there are also clear qualitative differences. One of the most relevant is the SCGLE prediction that the ergodic-attractive glass transition does not preempt the gas-liquid phase transition, but always intersects the corresponding spinodal curve on its high-concentration side. We also calculate the ergodic-non-ergodic phase diagram for the sticky hard-sphere model to illustrate the dependence of the predicted SCGLE dynamic phase diagram on the choice of one important constituent element of the SCGLE theory

  11. Glass-liquid-glass reentrance in mono-component colloidal dispersions

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez-Gonzalez, P E; Medina-Noyola, M [Instituto de Fisica ' Manuel Sandoval Vallarta' , Universidad Autonoma de San Luis Potosi, Alvaro Obregon 64, 78000 San Luis Potosi, SLP (Mexico); Vizcarra-Rendon, A [Unidad Academica de Fisica, Universidad Autonoma de Zacatecas, Paseo la Bufa y Calzada Solidaridad, 98600, Zacatecas, Zac. (Mexico); Guevara-Rodriguez, F de J [Coordinacion de IngenierIa Molecular, Instituto Mexicano del Petroleo, Eje Central Lazaro Cardenas 152, 07730 Mexico, DF (Mexico)

    2008-05-21

    The self-consistent generalized Langevin equation (SCGLE) theory of colloid dynamics is employed to describe the ergodic-non-ergodic transition in model mono-disperse colloidal dispersions whose particles interact through hard-sphere plus short-ranged attractive forces. The ergodic-non-ergodic phase diagram in the temperature-concentration state space is determined for the hard-sphere plus attractive Yukawa model within the mean spherical approximation for the static structure factor by solving a remarkably simple equation for the localization length of the colloidal particles. Finite real values of this property signals non-ergodicity and determines the non-ergodic parameters f(k) and f{sub s}(k). The resulting phase diagram for this system, which involves the existence of reentrant (repulsive and attractive) glass states, is compared with the corresponding prediction of mode coupling theory. Although both theories coincide in the general features of this phase diagram, there are also clear qualitative differences. One of the most relevant is the SCGLE prediction that the ergodic-attractive glass transition does not preempt the gas-liquid phase transition, but always intersects the corresponding spinodal curve on its high-concentration side. We also calculate the ergodic-non-ergodic phase diagram for the sticky hard-sphere model to illustrate the dependence of the predicted SCGLE dynamic phase diagram on the choice of one important constituent element of the SCGLE theory.

  12. Mono or 3D video production for scientific dissemination of nuclear energy applications

    International Nuclear Information System (INIS)

    Freitas, Victor Goncalves G.; Mol, Antonio Carlos A.; Biermann, Bruna; Jorge, Carlos Alexandre F.; Araujo, Tawein

    2011-01-01

    This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

  13. Probing the dark sector through mono-Z boson leptonic decays

    Science.gov (United States)

    Yang, Daneng; Li, Qiang

    2018-02-01

    Collider search for dark matter production has been performed over the years based on high p T standard model signatures balanced by large missing transverse energy. The mono-Z boson production with leptonic decay has a clean signature with the advantage that the decaying electrons and muons can be precisely measured. This signature not only enables reconstruction of the Z boson rest frame, but also makes possible recovery of the underlying production dynamics through the decaying lepton angular distribution. In this work, we exploit full information carried by the leptonic Z boson decays to set limits on coupling strength parameters of the dark sector. We study simplified dark sector models with scalar, vector, and tensor mediators and observe among them different signatures in the distribution of angular coefficients. Specifically, we show that angular coefficients can be used to distinguish different scenarios of the spin-0 and spin-1 models, including the ones with parity-odd and charge conjugation parity-odd operators. To maximize the statistical power, we perform a matrix element method study with a dynamic construction of event likelihood function. We parametrize the test statistic such that sensitivity from the matrix element is quantified through a term measuring the shape difference. Our results show that the shape differences provide significant improvements in the limits, especially for the scalar mediator models. We also present an example application of a matrix-element-kinematic-discriminator, an easier approach that is applicable for experimental data.

  14. Labelling by deuteration and nitroxide radicals of mono-, oligo- and polysaccharides (cellulose and amylose)

    Energy Technology Data Exchange (ETDEWEB)

    Odier, L

    1975-01-01

    The application of NMR and deuteration labelling to the investigation of polysaccharides has led to considerable progress in recent years in the knowledge of these compounds. Although far more recent, the introduction of spin labelling techniques in the investigation of polymers, has given rise to interesting EPR studies of synthetic and natural macromolecules, but nothing appears to have been accomplished in the area of spin labelling of polysaccharides. This work was aimed at applying these two techniques to the study of glucose derivatives and of some of its oligomers (low molecular weight polymers): cellobiose, maltose and cyclodextrins; and its polymers: cellulose and amylose. Irrespective of the technique employed, the complexity of the polymers and problems connected with handling them always require the same procedure: an initial study of a model compound generally prepared from the monomer or an oligomer (dimer), followed by the oligomers, and finally the polymer. Part 1 is devoted to the deuteration labelling of mono- and oligosaccharides. Part 2 concerns spin labelling of cellulose acetate. In part 3, an attempt is made to apply the spin labelling technique to the determination of conformations of two disaccharides of different glycosidic configurations: cellobiose and maltose. Part 4 is devoted to spin and deuteration labelling of ..cap alpha.. and ..beta.. cyclodextrins.

  15. Geology of epithermal silver-gold bulk-mining targets, bodie district, Mono County, California

    Science.gov (United States)

    Hollister, V.F.; Silberman, M.L.

    1995-01-01

    The Bodie mining district in Mono County, California, is zoned with a core polymetallic-quartz vein system and silver- and gold-bearing quartz-adularia veins north and south of the core. The veins formed as a result of repeated normal faulting during doming shortly after extrusion of felsic flows and tuffs, and the magmatic-hydrothermal event seems to span at least 2 Ma. Epithermal mineralization accompanied repeated movement of the normal faults, resulting in vein development in the planes of the faults. The veins occur in a very large area of argillic alteration. Individual mineralized structures commonly formed new fracture planes during separate fault movements, with resulting broad zones of veinlets growing in the walls of the major vein-faults. The veinlet swarms have been found to constitute a target estimated at 75,000,000 tons, averaging 0.037 ounce gold per ton. The target is amenable to bulkmining exploitation. The epithermal mineralogy is simple, with electrum being the most important precious metal mineral. The host veins are typical low-sulfide banded epithermal quartz and adularia structures that filled voids created by the faulting. Historical data show that beneficiation of the simple vein mineralogy is very efficient. ?? 1995 Oxford University Press.

  16. Developing new methods for the mono-end functionalization of living ring opening metathesis polymers.

    Science.gov (United States)

    Kilbinger, Andreas F M

    2012-01-01

    In this article we present a review of our recent results in one area of research we are involved in. All research efforts in our group focus on functional polymers and new ways of gaining higher levels of control with regard to the placement of functional groups within these polymers. Here, the living ring opening metathesis polymerization (ROMP) will be reviewed for which end-functionalization methods had been rare until very recently. Polymers carrying particular functional groups only at the chain-ends are, however, very interesting for a variety of industrial and academic applications. Polymeric surfactants and polymer-protein conjugates are two examples for the former and polymer-β-sheet-peptide conjugates one example for the latter. The functionalization of macroscopic or nanoscopic surfaces often relies on mono-end functional polymers. Complex macromolecular architectures are often constructed from macromolecules carrying exactly one functional group at their chain- end. The ring opening metathesis polymerization is particularly interesting in this context as it is one of the most functional group tolerant polymerization methods known. Additionally, high molecular weight polymers are readily accessible with this technique, a feature that living radical polymerizations often struggle to achieve. Finding new ways of functionalizing the polymer chain-end of ROMP polymers has therefore been a task long overdue. Here, we present our contribution to this area of research.

  17. Influence of nitrogen and phosphorous on the growth and root morphology of Acer mono.

    Science.gov (United States)

    Razaq, Muhammad; Zhang, Peng; Shen, Hai-Long; Salahuddin

    2017-01-01

    Nitrogen and phosphorous are critical determinants of plant growth and productivity, and both plant growth and root morphology are important parameters for evaluating the effects of supplied nutrients. Previous work has shown that the growth of Acer mono seedlings is retarded under nursery conditions; we applied different levels of N (0, 5, 10, and 15 g plant-1) and P (0, 4, 6 and 8 g plant-1) fertilizer to investigate the effects of fertilization on the growth and root morphology of four-year-old seedlings in the field. Our results indicated that both N and P application significantly affected plant height, root collar diameter, chlorophyll content, and root morphology. Among the nutrient levels, 10 g N and 8 g P were found to yield maximum growth, and the maximum values of plant height, root collar diameter, chlorophyll content, and root morphology were obtained when 10 g N and 8 g P were used together. Therefore, the present study demonstrates that optimum levels of N and P can be used to improve seedling health and growth during the nursery period.

  18. Inkjet Printing Based Mono-layered Photonic Crystal Patterning for Anti-counterfeiting Structural Colors

    Science.gov (United States)

    Nam, Hyunmoon; Song, Kyungjun; Ha, Dogyeong; Kim, Taesung

    2016-01-01

    Photonic crystal structures can be created to manipulate electromagnetic waves so that many studies have focused on designing photonic band-gaps for various applications including sensors, LEDs, lasers, and optical fibers. Here, we show that mono-layered, self-assembled photonic crystals (SAPCs) fabricated by using an inkjet printer exhibit extremely weak structural colors and multiple colorful holograms so that they can be utilized in anti-counterfeit measures. We demonstrate that SAPC patterns on a white background are covert under daylight, such that pattern detection can be avoided, but they become overt in a simple manner under strong illumination with smartphone flash light and/or on a black background, showing remarkable potential for anti-counterfeit techniques. Besides, we demonstrate that SAPCs yield different RGB histograms that depend on viewing angles and pattern densities, thus enhancing their cryptographic capabilities. Hence, the structural colorations designed by inkjet printers would not only produce optical holograms for the simple authentication of many items and products but also enable a high-secure anti-counterfeit technique. PMID:27487978

  19. Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents

    Directory of Open Access Journals (Sweden)

    Jing Zhang

    2014-11-01

    Full Text Available The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO, relative to currently available inotropic drugs, has prompted us to intensively research and develop LZDO as a potent positive inotropic agent. In this study, to obtain LZDO alternatives for oral chronic administration, a series of long-chain fatty carboxylic mono- and dual-esters of LZDO were synthesized, and preliminarily evaluated for physicochemical properties and bioconversion. Enhanced lipophilic properties and decreased solubility of the prodrugs were observed as the side chain length increased. All esters showed conspicuous chemical stability in phosphate buffer (pH 7.4. Moreover, the enzymatic hydrolysis of esters in human plasma and human liver microsomes confirmed that the majority of esters were converted to LZDO, with release profiles that varied due to the size and structure of the side chain. In vivo pharmacokinetic studies following oral administration of monopivaloyl (M5, monodecyl (M10 and monododecyl (M12 esters demonstrated the evidently extended half-lives relative to LZDO dosed alone. In particular the monopivaloyl ester M5 exhibited an optimal pharmacokinetic profile with appropriate physiochemical characteristics.

  20. Effect of space flight on physiological indexes and antioxidant enzymes of Acer mono

    International Nuclear Information System (INIS)

    Li Yunfei; Yang Fan; Ren Yunhui

    2012-01-01

    To investigate the effects of space flight on physiological indexes and antioxidant enzymes of Acer mono, seeds were divided into two groups, one was treated by carrying on Shijian No.8 breeding satellite for 15 d, and the other was kept on the ground as controls. 5 years old seedlings that derived from the seeds of space flight and the seeds of ground control were chosen as materials, then the growth characteristics, photosynthetic characteristics, soluble protein content and antioxidant enzymes activities were analyzed. The results showed that the plant growth, net photosynthetic rate (Pn), chlorophyll content, superoxide dismutase (SOD) activity and soluble protein content of seedlings after space flight were much higher than those of ground control. However, the changes of malondialdehyde (MDA) content, peroxidase (POD), transpiration rate (Tr), intercellular carbon dioxide concentration (Ci) and stomatal conductance (Gs) were not significantly changed. The net photosynthetic rate (Pn), as well as the plant growth of seedlings after space flight were higher than those of the control. The improved ability of photosynthesis may be one of the reasons that seedlings from seeds of space flight have higher speed of growth. (authors)

  1. Intracellular thiol levels and radioresistance: Studies with glutathione and glutathione mono ethyl ester

    International Nuclear Information System (INIS)

    Astor, M.B.; Meister, A.; Anderson, M.E.

    1987-01-01

    Intracellular thiols such as glutathione (GSH) protect cells against free radicals formed during oxidative metabolism or from exposure to drugs or ionizing radiation. The role of intracellular GSH in the repair of radiation induced free radical damage was studied using GSH or its analog glutathione mono ethyl ester (GEE), which readily penetrates into the cell. Chinese hamster V79 cells with normal GSH levels were afforded equal protection under aerated and hypoxic conditions (DMF = 1.2 OER = 3.7) by both 10 mM GSH and GEE although GEE had raised interacellular GSH levels three-fold. Growth of V79 cells in cysteine free media resulted in undetectable levels of GSH and OER of 2.2 with no change in aerated survival. Restoration of intracellular GSH by 10 mM GEE resulted in an increase of the OER from 2.2. to 3.8 (DMF = 1.7). Only 14% of the intracellular GSH needs to be repleted to give an OER of 3.0. These experiments provide evidence that thiols do play a role in the oxygen effect and are present at levels in excess of what is necessary for maximal radioprotection

  2. Nickel Electroless Plating: Adhesion Analysis for Mono-Type Crystalline Silicon Solar Cells.

    Science.gov (United States)

    Shin, Eun Gu; Rehman, Atteq ur; Lee, Sang Hee; Lee, Soo Hong

    2015-10-01

    The adhesion of the front electrodes to silicon substrate is the most important parameters to be optimized. Nickel silicide which is formed by sintering process using a silicon substrate improves the mechanical and electrical properties as well as act as diffusion barrier for copper. In this experiment p-type mono-crystalline czochralski (CZ) silicon wafers having resistivity of 1.5 Ω·cm were used to study one step and two step nickel electroless plating process. POCl3 diffusion process was performed to form the emitter with the sheet resistance of 70 ohm/sq. The Six, layer was set down as an antireflection coating (ARC) layer at emitter surface by plasma enhanced chemical vapor deposition (PECVD) process. Laser ablation process was used to open SiNx passivation layer locally for the formation of the front electrodes. Nickel was deposited by electroless plating process by one step and two step nickel electroless deposition process. The two step nickel plating was performed by applying a second nickel deposition step subsequent to the first sintering process. Furthermore, the adhesion analysis for both one step and two steps process was conducted using peel force tester (universal testing machine, H5KT) after depositing Cu contact by light induced plating (LIP).

  3. Mono or 3D video production for scientific dissemination of nuclear energy applications

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Victor Goncalves G.; Mol, Antonio Carlos A.; Biermann, Bruna; Jorge, Carlos Alexandre F., E-mail: mol@ien.gov.b, E-mail: vgoncalves@ien.gov.b, E-mail: calexandre@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Araujo, Tawein [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola de Belas Artes; Legey, Ana Paula [Universidade Gama Filho (UGF), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

  4. Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.

    Science.gov (United States)

    Vavříková, Eva; Langschwager, Fanny; Jezova-Kalachova, Lubica; Křenková, Alena; Mikulová, Barbora; Kuzma, Marek; Křen, Vladimír; Valentová, Kateřina

    2016-06-07

    A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside) esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C₅- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C₂), malonic (C₃), succinic (C₄) and maleic (C₄) acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin-Ciocalteau reagent (FCR) and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) than isoquercitrin; ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging activity was comparable. Dodecanoate and palmitate were the least active in FCR and ABTS scavenging; dodecanoate and hemiglutarate were the strongest DPPH scavengers. In contrast, most derivatives were much better inhibitors of microsomal lipoperoxidation than isoquercitrin; butyrate and hexanoate were the most efficient. Anti-lipoperoxidant activity of monocarboxylic derivatives, except acetates, decreased with increasing aliphatic chain. The opposite trend was noted for dicarboxylic acid hemiesters, isoquercitrin hemidodecanedioate being the most active. Overall, IQ butyrate, hexanoate and hemidodecanedioate are the most promising candidates for further studies.

  5. The k0-based neutron activation analysis: a mono standard to standardless approach of NAA

    International Nuclear Information System (INIS)

    Acharya, R.; Nair, A.G.C.; Sudarshan, K.; Goswami, A.; Reddy, A.V.R.

    2006-01-01

    The k 0 -based neutron activation analysis (k 0 -NAA) uses neutron flux parameters, detection efficiency and nuclear constants namely k 0 and Q 0 for the determination of concentration of elements. Gold ( 197 Au) or any other element having suitable nuclear properties is used as external or internal single comparator. This article describes the principle of k 0 -NAA and standardization of method by characterization of reactor irradiation sites and calibration of efficiency of the detector and applications. The method was validated using CRMs obtained from USGS, IAEA and NIST. The applications of method includes samples like gemstones (ruby, beryl and emerald), sediments, manganese nodules and encrustations, cereals, and medicinal and edible leaves. Recently, a k-o-based internal mono standard INAA (IM-NAA) method using in-situ relative efficiency has been standardized by us for the analysis of small and large samples of different shapes and sizes. The method was applied to a new meteorite sample and large size wheat samples. Non-standard size and shape samples of nuclear cladding materials namely zircaloy 2 and 4, stainless steels (SS 316M and D9) and 1S aluminium were analysed. Standard-less analysis of these cladding materials was possible by mass balance approach since all the major and minor elements were amenable to NAA. (author)

  6. Synthesis, chemical and biological properties of the new mono- and bis-derivatives of imidazoles

    Directory of Open Access Journals (Sweden)

    E. V. Welchinska

    2014-12-01

    Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine. The lectin’s preparations were obtained by treatment of culture Liquid of saprophytic strain Bacillus from Ukrainian Collection of Microorganisms of Institute of Microbiology and Virology (IMV: B. polymyxa 102 KGU; in future: lectine 102 was clarified by treatment with ammonium sulfate (70% concentration of a saturated solution. Results. For the first time the interaction of a series of imidazole substituted with halothane compounds have been investigated, the conditions of the reaction have been defined, the methods have been developed and the composition of the reaction products has been studied. The studies revealed that the initial heterocycle, namely imidazole reacts with the intermediate product of halothane conversion in an alkaline medium, under conditions of phase transfer catalysis DB-18-crown-6 in a solvent system (dimethyl formamide - benzene - diethyl ether or in another variant: in DMSO with the presence of anhydrous potassium carbonate with the formation of mono-and bis-derivatives of imidazole. This reaction made possible a new strategy of synthesis of selectively poly-functionalized molecules, the chemical structure of which is available for incorporation of new pharmacophore fragments into molecule. It has been discovered that mono-, bis-derivatives of imidazole, molecular complex of bis-derivative of imidazole and antitumour bacterial lectin are low toxic preparations (LD50: from 278 mg/kg to 102 mg/kg. Conclusion. New mono- and bis-adducts of imidazole, molecular complex of Bacillus polymyxa 102 KGU and imidazole bis-derivative have been prepared and its toxicity has been tested. New convenient methods for the preparation of heterocyclic mono- and bis-adducts of imidazole with 1,1,1-trifluoro-2-bromo-2-chloroethane (halothane have been described. The reactions were catalyzed by DB-18-crown-6-complex (at the alkali medium. Investigation of the critical toxicity

  7. Mono-(2-Ethylhexyl Phthalate Promotes Pro-Labor Gene Expression in the Human Placenta.

    Directory of Open Access Journals (Sweden)

    Ximi K Wang

    Full Text Available Women exposed to phthalates during pregnancy are at increased risk for delivering preterm, but the mechanism behind this relationship is unknown. Placental corticotropin-releasing hormone (CRH and cyclooxygenase-2 (COX-2 are key mediators of parturition and are regulated by the non-canonical NF-kB (RelB/p52 signaling pathway. In this study, we demonstrate that one of the major phthalate metabolites, mono-(2-ethylhexyl-phthalate (MEHP, increased CRH and COX-2 mRNA and protein abundance in a dose-dependent manner in primary cultures of cytotrophoblast. This was coupled with an increase in nuclear import of RelB/p52 and its association with the CRH and COX-2 promoters. Silencing of NF-kB inducing kinase, a central signaling component of the non-canonical NF-kB pathway, blocked MEHP-induced upregulation of CRH and COX-2. These results suggest a potential mechanism mediated by RelB/p52 by which phthalates could prematurely induce pro-labor gene activity and lead to preterm birth.

  8. Ikaite precipitation by mixing of shoreline springs and lake water, Mono Lake, California, USA

    Science.gov (United States)

    Bischoff, James L.; Stine, Scott; Rosenbauer, Robert J.; Fitzpatrick, John A.; Stafford, Thomas W., Jr.

    1993-08-01

    Metastable ikaite (CaCO 3·6H 2O) forms abundantly during winter months along the south shoreline of Mono Lake where shoreline springs mix with lake water. Ikaite precipitates because of its decreased solubility at low temperature and because of orthophosphate-ion inhibition of calcite and aragonite. During the spring some of the ikaite is transformed to anhydrous CaCO 3 and is incorporated into tufa, but most is dispersed by wave action into the lake where it reacts to form gaylussite (Na 2Ca(CO 3) 2· 5H 2O). Spring waters have low pH values, are dominantly Ca-Na-HCO 3, have low radiocarbon activities, and are mixtures of deep-seated geothermal and cold groundwaters. Chemical modeling reveals that precipitation of CaCO 3 can occur over a broad range of mixtures of spring and lake water with a maximum production occurring at 96% spring water and 4% lake water. Under these conditions all the Ca and a significant fraction of the CO 3 of the precipitate is spring supplied. A radiocarbon age of 19,580 years obtained on a natural ikaite sample supports this conclusion. With the springs supplying a large and probably variable portion of the carbonate, and with apparent 14C age of the carbonate varying from spring to spring, tufa of similar actual antiquity may yield significantly different 14C dates, making tufa at this location unsuitable for absolute age dating by the radiocarbon method.

  9. /Cu-Al System

    Science.gov (United States)

    Kish, Orel; Froumin, Natalya; Aizenshtein, Michael; Frage, Nachum

    2014-05-01

    Wettability and interfacial interaction of the Ta2O5/Cu-Al system were studied. Pure Cu does not wet the Ta2O5 substrate, and improved spreading is achieved when relatively a high fraction of the active element (~40 at.% Al) was added. The Al2O3 and AlTaO4 phases were observed at the Ta2O5/Cu-Al interface. A thermodynamic evaluation allowed us to suggest that the lack of wetting bellow 40 at.% Al is due to the presence of a native oxide, which covers the drop. The conditions of the native oxide decomposition and the formation of the volatile Al2O suboxide strongly depend on the vacuum level during sessile drop experiments and the composition of the Cu-Al alloy. In our case, Al contents greater than 40% provides thermodynamic conditions for the formation of Al2O (as a result of Al reaction with Al2O3) and the drop spreading. It was suggested that the final contact angle in the Ta2O5/Cu-Al system (50°) is determined by Ta adsorption on the newly formed alumina interlayer.

  10. Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

    Energy Technology Data Exchange (ETDEWEB)

    King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T. [Nottingham Univ. (United Kingdom). School of Chemistry; Tuna, Floriana; McInnes, Eric J.L. [Manchester Univ. (United Kingdom). School of Chemistry

    2013-04-26

    Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). [German] Die direkte Oxidation eines Triamidoamin-Uran(III)-Komplexes mit Trimethyl-N-oxid liefert einen terminalen Uran(V)-Mono(oxo)komplex, der das erste gesicherte Beispiel eines Uran(V)-Einzelmolekuelmagnets ist. Dieser monometallische Komplex zeigt eindeutig, dass ein starkes axiales und somit anisotropes Ligandenfeld die begrenzte magnetische Anisotropie von Uran(V) beseitigen kann.

  11. Elastic source model of the North Mono eruption (1325-1368 A.D.) based on shoreline deformation

    Science.gov (United States)

    Shaffer, Wil; Bursik, Marcus; Renshaw, Carl

    2010-12-01

    Topographic data from the Shuttle Radar Topography Mission (SRTM) captures the permanent deformation of a prominent highstand of Mono Lake, California USA. Deformation of the Dechambeau Ranch highstand shoreline was measured using the elevation of the beach berm—shoreline bluff break-in-slope. Point source models and a boundary element dike model were used to approximate the source of deformation underneath the northern end of the Mono Craters. The point source model could not adequately explain the observed deformation. The dike model yielded the best results for a NW trending dike dipping 60° NE and inflated to widths greater than 60 m. The results suggest that the geometry of the source is more complex than a simple vertical dike and that the deformation is better explained with a dipping dike following a normal fault, or an elongated cryptodome.

  12. A load-displacement based approach to assess the bearing capacity and deformations of mono-bucket foundations

    DEFF Research Database (Denmark)

    Vahdatirad, Mohammadjavad; Diaz, Alberto Troya; Nielsen, Søren

    2016-01-01

    It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load–displacemen......It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load...... and run the calculations is proposed. The model is validated, and its accuracy is analyzed, by comparison with field test results for a bucket foundation installed in silty, sandy soil....

  13. Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture.

    Science.gov (United States)

    Kaszuba-Zwoinska, J; Chorobik, P; Juszczak, K; Zaraska, W; Thor, P J

    2012-10-01

    Current studies were aimed to elucidate influence of pulsed electromagnetic field stimulation on cell viability and apoptosis induction pathways. For the experimental model we have chosen monocytic cell line MonoMac6 and several apoptosis inducers with different mechanism of death induction like puromycin, colchicine, cyclophosphamide, minocycline and hydrogen peroxide. MonoMac6 cell line was grown at density 1x10(5) cells/well in 96-well culture plates. To induce cell death cell cultures were treated with different apoptosis inducers like puromycin, colchicine, cyclophosphamide, minocycline, hydrogen peroxide and at the same time with pulsed electromagnetic field 50 Hz, 45±5 mT (PEMF) for 4 hour per each stimulation, three times, in 24 hours intervals. Afterwards, cells were harvested for flow cytometry analysis of cell viability measured by annexin V-APC labeled and propidium iodide staining. Expression of apoptosis related genes was evaluated by semi quantitative reverse transcription (RT)-PCR assay. NuPAGE Novex Western blot analysis was carried out for apoptosis inducing factor (AIF) abundance in cytosolic and nuclear extracts of MonoMac6 cells. Puromycin, colchicine and minocycline activated cells and simultaneously treated with PEMF have shown out diminished percentage of annexinV positive (AnV+) cells comparing to controls without PEMF stimulation. MonaMac6 cells puromycin/colchicyne and PEMF treated were to a higher extent double stained (AnV+,PI+), which means increased late apoptotic as well as necrotic (PI+) cells, than non-stimulated controls. On the other hand, minocycline activated cells prior to PEMF treatment showed diminished amount of apoptotic and necrotic (annexin V, annexin V and propidium iodide, propidium iodide positive staining) cells. The opposite effect of PEMF on the percentage of annexin V positively stained cells has been achieved after treatment of MonoMac6 culture with cyclophoshamide and hydrogen peroxide. PEMF enhanced early

  14. The use of a manual-driven group cognitive behavior therapy in a Brazilian sample of obese individuals with binge-eating disorder Utilização de terapia cognitivo-comportamental em grupo baseada em manual em uma amostra brasileira de indivíduos obesos com transtorno da compulsão alimentar periódica

    Directory of Open Access Journals (Sweden)

    Mônica Duchesne

    2007-03-01

    Full Text Available OBJECTIVE: To assess the effectiveness of a manual-based cognitive behavior therapy adapted to a group format in a sample of Brazilian obese subjects with binge-eating disorder. METHOD: In an open trial, 21 obese subjects with binge-eating disorder received a group cognitive-behavioral therapy program. Changes in binge-eating frequency, weight, body shape concerns, and depressive symptoms were compared between baseline and the end of the study. RESULTS: The mean frequency of binge-eating episodes significantly decreased from baseline to post-treatment (p OBJETIVO: Avaliar a efetividade da terapia cognitivo-comportamental baseada em um manual adaptado para o formato de grupo em uma amostra brasileira de obesos com transtorno da compulsão alimentar periódica. MÉTODO: Em um estudo aberto, 21 pacientes obesos com transtorno da compulsão alimentar periódica participaram de um programa da terapia cognitivo-comportamental em grupo. A freqüência da compulsão alimentar, o peso corporal, o grau de satisfação com a forma corporal e os sintomas depressivos foram avaliados no início do tratamento e no final do estudo. RESULTADOS: Houve uma redução estatisticamente significativa da freqüência média de episódios de compulsão alimentar entre a linha de base e o final do tratamento (p < 0,001, com uma taxa de remissão de episódios no final do estudo de 76,1%. Foi observada, também, uma redução significativa dos sintomas depressivos e da insatisfação com a forma corporal (p < 0,001. Adicionalmente, a perda de peso foi clínica e estatisticamente significativa. CONCLUSÃO: A utilização de terapia cognitivo-comportamental baseada em um manual adaptado para o transtorno da compulsão alimentar periódica resultou em melhora significativa da compulsão alimentar, do peso corporal, da preocupação com a forma corporal e dos sintomas depressivos associados ao transtorno da compulsão alimentar periódica nessa amostra.

  15. Psicologia e nutrição: predizendo a intenção comportamental de aderir a dietas de redução de peso entre obesos de baixa renda Psychology and nutrition: predicting behavioral intention to follow weight reduction diets among low-income obese patients

    Directory of Open Access Journals (Sweden)

    Ana Paula Rodrigues Cavalcanti

    2005-04-01

    Full Text Available O presente estudo foi realizado entre 189 obesos de baixa renda atendidos por nutricionistas na rede pública de saúde de João Pessoa, Paraíba. Levantou as crenças positivas e negativas e os referentes mais expressivos sobre estes pacientes quanto ao comportamento de seguir uma dieta médica para redução de peso. Um instrumento de medida da intenção comportamental de efetivamente seguir tais dietas foi construído, o que permitiu verificar a ênfase do aspecto normativo geral e atitudinal nos obesos com renda de até um salário-mínimo sobre sua intenção comportamental. Isto pode indicar dois pontos eficazes a serem explorados em comunicações dirigidas a esta classe social em campanhas de saúde para redução de peso. Esta medição torna-se útil para ações preventivas de saúde; a obesidade é considerada uma epidemia mundial carente de controle imediato, aumentando em incidência principalmente nas classes mais baixas dos países em desenvolvimento.The present study was accomplished with 189 low income obese attended by public health nutritionists of João Pessoa, Paraíba. We found out positive and negative beliefs plus the most expressive referees on these patients about the behavior of following a medical diet to reduce weight. This permitted to build a behavioral intention measurement instrument to check those who might really follow these diets. It was verified the emphasis on general normative and attitudinal aspects over obese who had up to one minimum-wage income. This may indicate two efficacious points to be explored on targeted communications to this social class during weight loss public health campaigns. This measurement can be turned into preventive health actions; obesity is considered worldwide as epidemics, in need of immediate control, growing in incidence mainly among lower ranks of the population of developing countries.

  16. Bankole et al (2)

    African Journals Online (AJOL)

    DELL

    Relationships of Clay-filled Channels on the Delta Flanks (Modified after Doust and Omatsola, 1990 and Lawrence et al., 2002). ... and in the Indo-Malaysian area (Germeraad et al.,. 1968). The genus ..... Upper Cretaceous of British Guiana.

  17. Lou Gehrig's Disease (ALS)

    Science.gov (United States)

    ... disease. Who Gets ALS? Although this disease can strike anyone, ALS is extremely rare in kids. According ... home to provide care that the family cannot handle alone. Living With Lou Gehrig's Disease Living with ...

  18. Aussprache als motorische Fertigkeit

    DEFF Research Database (Denmark)

    Bonner, Maria

    2013-01-01

    Authentische Aussprache gilt im Fremdsprachenunterricht als schwer erreichbares Ziel, fremdsprachlicher Akzent wird als nahezu unvermeidbar gesehen. Weder die Hypothese einer kritischen Periode für den Erwerb einer authentischen Aussprache noch das Konzept der Fossilierung im Sprachlernprozess...

  19. Bayesian risk maps for Schistosoma mansoni and hookworm mono-infections in a setting where both parasites co-exist

    Directory of Open Access Journals (Sweden)

    Giovanna Raso

    2007-11-01

    Full Text Available There is growing interest in the use of Bayesian geostatistical models for predicting the spatial distribution of parasitic infections, including hookworm, Schistosoma mansoni and co-infections with both parasites. The aim of this study was to predict the spatial distribution of mono-infections with either hookworm or S. mansoni in a setting where both parasites co-exist. School-based cross-sectional parasitological and questionnaire surveys were carried out in 57 rural schools in the Man region, western Côte d’Ivoire. A single stool specimen was obtained from each schoolchild attending grades 3-5. Stool specimens were processed by the Kato-Katz technique and an ether concentration method and examined for the presence of hookworm and S. mansoni eggs. The combined results from the two diagnostic approaches were considered for the infection status of each child. Demographic data (i.e. age and sex were obtained from readily available school registries. Each child’s socio-economic status was estimated, using the questionnaire data following a household-based asset approach. Environmental data were extracted from satellite imagery. The different data sources were incorporated into a geographical information system. Finally, a Bayesian spatial multinomial regression model was constructed and the spatial patterns of S. mansoni and hookworm mono-infections were investigated using Bayesian kriging. Our approach facilitated the production of smooth risk maps for hookworm and S. mansoni mono-infections that can be utilized for targeting control interventions. We argue that in settings where S. mansoni and hookworm co-exist and control efforts are under way, there is a need for both mono- and co-infection risk maps to enhance the cost-effectiveness of control programmes.

  20. Preparation of diesel emulsion using auxiliary emulsifier mono ethylene glycol and utilization in a turbocharged diesel engine

    International Nuclear Information System (INIS)

    Yilmaz, Emre; Solmaz, Hamit; Polat, Seyfi; Uyumaz, Ahmet; Şahin, Fatih; Salman, M. Sahir

    2014-01-01

    Highlights: • Mono-ethylene glycol was used as an auxiliary emulsifier. • Using mono ethylene glycol prolonged precipitation duration of emulsions. • With using E5 and E10 fuels engine torque averagely increased by 0.35% and 1.73% respectively. • It was found that specific fuel consumption of emulsions is lower than diesel. • Using E10 fuel reduced CO, NO x and soot emissions 44%, 47% and 5% respectively. - Abstract: Diesel engines are used widely as they have lower fuel consumption and higher thermal efficiency in transportation sector. However, the emitted high NO x , CO and soot emissions have led researchers to search different alternative fuels. At this point, diesel fuels emulsions help to reduce exhaust emissions. In this study, the effects of diesel fuel emulsions containing 5% (E5) and 10% (E10) water on engine performance an exhaust emissions has been investigated. Mono ethylene glycol was used as an auxiliary emulsifier in the preparation of the emulsion. Use of the mono ethylene glycol reduced the subsidence rate of the E5 and E10 about 34.5% and 47.1% respectively. The experiments were conducted at full load condition and at 2500, 3250 and 4000 rpm engine speeds. Engine torque and power increased according to diesel fuel between 2400 and 3600 engine speed range when emulsified fuels were used. But significant reductions were observed after that engine speed range. It was observed that the nitrogenoxide (NO x ) emission reduced 5.42% and 11.01% with using E5 and E10 fuel respectively according to diesel fuel at 2500 rpm. Also the soot emissions reduced 12.39% and 22.97% with using E5 and E10

  1. Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

    International Nuclear Information System (INIS)

    King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T.; Tuna, Floriana; McInnes, Eric J.L.

    2013-01-01

    Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). [de

  2. Microwave Photocatalysis of Mono-Chloroacetic Acid over Nanoporous Titanium(IV) Oxide Thin Films Using Mercury Electrodeless Discharge Lamps

    Czech Academy of Sciences Publication Activity Database

    Církva, Vladimír; Žabová, Hana; Hájek, Milan

    2008-01-01

    Roč. 198, č. 1 (2008), s. 13-17 ISSN 1010-6030 R&D Projects: GA ČR GA104/06/0992; GA ČR GA104/07/1212 Institutional research plan: CEZ:AV0Z40720504 Keywords : microwave-assisted photocatalysis * electrodeless discharge lamp * mono-chloroacetic acid Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 2.362, year: 2008

  3. Effects of neutron irradiation on microstructure and deformation behaviour of mono- and polycrystalline molybdenum and its alloys

    DEFF Research Database (Denmark)

    Singh, B.N.; Evans, J.H.; Horsewell, A.

    1998-01-01

    The influence of neutron irradiation on microstructural evolution and mechanical properties of mono- and polycrystalline molybdenum and its alloys has been investigated. Tensile specimens and 3 mm diameter discs of monocrystals of pure molybdenum and Mo-5%Re were irradiated with fission neutrons...... microscopy are presented and discussed in terms of intracascade clustering of self-interstitial atoms and the role of one-dimensional glide of these clusters in controlling microstructural evolution and the resulting mechanical properties....

  4. Stochastic resonance in a time-delayed mono-stable system with correlated multiplicative and additive white noise

    International Nuclear Information System (INIS)

    Zhou Yu-Rong

    2011-01-01

    This paper considers the stochastic resonance for a time-delayed mono-stable system, driven by correlated multiplicative and additive white noise. It finds that the output signal-to-noise ratio (SNR) varies non-monotonically with the delayed times. The SNR varies non-monotonically with the increase of the intensities of the multiplicative and additive noise, with the increase of the correlation strength between the two noises, as well as with the system parameter. (general)

  5. Metal–Organic Frameworks Stabilize Mono(phosphine)–Metal Complexes for Broad-Scope Catalytic Reactions

    Energy Technology Data Exchange (ETDEWEB)

    Sawano, Takahiro; Lin, Zekai; Boures, Dean; An, Bing; Wang, Cheng; Lin, Wenbin (UC); (Xiamen)

    2016-08-10

    Mono(phosphine)–M (M–PR3; M = Rh and Ir) complexes selectively prepared by postsynthetic metalation of a porous triarylphosphine-based metal–organic framework (MOF) exhibited excellent activity in the hydrosilylation of ketones and alkenes, the hydrogenation of alkenes, and the C–H borylation of arenes. The recyclable and reusable MOF catalysts significantly outperformed their homogeneous counterparts, presumably via stabilizing M–PR3 intermediates by preventing deleterious disproportionation reactions/ligand exchanges in the catalytic cycles.

  6. Comparison study of exhaust plume impingement effects of small mono- and bipropellant thrusters using parallelized DSMC method.

    Directory of Open Access Journals (Sweden)

    Kyun Ho Lee

    Full Text Available A space propulsion system is important for the normal mission operations of a spacecraft by adjusting its attitude and maneuver. Generally, a mono- and a bipropellant thruster have been mainly used for low thrust liquid rocket engines. But as the plume gas expelled from these small thrusters diffuses freely in a vacuum space along all directions, unwanted effects due to the plume collision onto the spacecraft surfaces can dramatically cause a deterioration of the function and performance of a spacecraft. Thus, aim of the present study is to investigate and compare the major differences of the plume gas impingement effects quantitatively between the small mono- and bipropellant thrusters using the computational fluid dynamics (CFD. For an efficiency of the numerical calculations, the whole calculation domain is divided into two different flow regimes depending on the flow characteristics, and then Navier-Stokes equations and parallelized Direct Simulation Monte Carlo (DSMC method are adopted for each flow regime. From the present analysis, thermal and mass influences of the plume gas impingements on the spacecraft were analyzed for the mono- and the bipropellant thrusters. As a result, it is concluded that a careful understanding on the plume impingement effects depending on the chemical characteristics of different propellants are necessary for the efficient design of the spacecraft.

  7. Measurement and prediction of dabigatran etexilate mesylate Form II solubility in mono-solvents and mixed solvents

    International Nuclear Information System (INIS)

    Xiao, Yan; Wang, Jingkang; Wang, Ting; Ouyang, Jinbo; Huang, Xin; Hao, Hongxun; Bao, Ying; Fang, Wen; Yin, Qiuxiang

    2016-01-01

    Highlights: • Solubility of DEM Form II in mono-solvents and binary solvent mixtures was measured. • Regressed UNIFAC model was used to predict the solubility in solvent mixtures. • The experimental solubility data were correlated by different models. - Abstract: UV spectrometer method was used to measure the solubility data of dabigatran etexilate mesylate (DEM) Form II in five mono-solvents (methanol, ethanol, ethane-1,2-diol, DMF, DMAC) and binary solvent mixtures of methanol and ethanol in the temperature range from 287.37 K to 323.39 K. The experimental solubility data in mono-solvents were correlated with modified Apelblat equation, van’t Hoff equation and λh equation. GSM model and Modified Jouyban-Acree model were employed to correlate the solubility data in mixed solvent systems. And Regressed UNIFAC model was used to predict the solubility of DEM Form II in the binary solvent mixtures. Results showed that the predicted data were consistent with the experimental data.

  8. PCDFs, PCDDs, non-ortho PCBs, and mono-ortho PCBs in northern fulmars from the Faroe Islands

    Energy Technology Data Exchange (ETDEWEB)

    Ericson, I.M.; Hagberg, J.; Bavel van, B.; Lindstrom, G. [Orebro Univ., Orebro (Sweden). MTM Research Centre; Dam, M. [Food and Environment Agency, Torshavn, Faroe Islands (Denmark); Jensen, J.K.; Danielsen, J. [Faroese Museum of Natural History, Faroe Islands (Denmark)

    2005-07-01

    Eggs and tissues of Northern Fulmars have been used to monitor the contamination of the Canadian Arctic marine environment since 1975. Dioxin levels for northern fulmars in the Arctic are among the highest reported for birds. This study reported the results of analyses of dioxins (PCDDs) and non- and mono-ortho polychlorinated biphenyls (PCBs) in liver tissue from juvenile northern fulmars from the Faeroe Islands in 2003. The samples were collected during a traditional hunt and ground with anhydrous sodium sulfate. Sample extraction was performed using supercritical fluid extraction coupled to a solid phase liquid chromatography trap (SFE-LC). Target compounds were collected on a solid phase trap containing AX-21 carbon on ODS silica and eluted with 6 ml n-hexane/dichloromethane for non-planar compounds and xylene for planar compounds. PCDD and planar PCB analysis was performed on an a high resolution gas chromatography (GC) mass spectrometer (MS) operating at 10,000 resolution using EI ionization at 35 eV. Concentrations of PCDFs, PCDDs, non, and mono-ortho PCBs were detected in all samples. High levels of mono-ortho PCBs were detected, as well as non-ortho PCBs, PCDFs, and PCDDs. It was concluded that levels and congener patterns in fulmars from the Faroe Islands and the Canadian Arctic were comparable. However, slightly higher levels were detected in the Faeroe Islands samples. 9 refs., 1 tab., 2 figs.

  9. Amyotrophic lateral sclerosis (ALS)

    Science.gov (United States)

    Lou Gehrig disease; ALS; Upper and lower motor neuron disease; Motor neuron disease ... One out of 10 cases of ALS is due to a genetic defect. The cause is unknown in most other cases. In ALS, motor nerve cells (neurons) waste away ...

  10. Radiometric titration of diethanolamine with 65ZnSO4 and determination of mono and diethanolamines in a mixture by a radiometric method

    International Nuclear Information System (INIS)

    Varadan, R.; Sriman Narayanan, S.; Rao, V.R.S.

    1984-01-01

    Radiometric titration of diethanolamine with 65 ZnSO 4 is reported. Determination of individual amounts of mono- and diethanolamines in a mixture is described. The procedure is simple, rapid and accurate. (author)

  11. Radiometric titration of diethanolamine with /sup 65/ZnSO/sub 4/ and determination of mono and diethanolamines in a mixture by a radiometric method

    Energy Technology Data Exchange (ETDEWEB)

    Varadan, R.; Sriman Narayanan, S.; Rao, V.R.S. (Indian Inst. of Tech., Madras. Dept. of Chemistry)

    1984-08-16

    Radiometric titration of diethanolamine with /sup 65/ZnSO/sub 4/ is reported. Determination of individual amounts of mono- and diethanolamines in a mixture is described. The procedure is simple, rapid and accurate.

  12. Ketone deprotonation mediated by mono- and heterobimetallic alkali and alkaline earth metal amide bases: structural characterization of potassium, calcium, and mixed potassium-calcium enolates.

    Science.gov (United States)

    He, Xuyang; Noll, Bruce C; Beatty, Alicia; Mulvey, Robert E; Henderson, Kenneth W

    2004-06-23

    Potassium, calcium, and mixed potassium-calcium amide combinations have been shown to be efficient reagents in enolization reactions, and a set of representative intermediate mono- and heterobimetallic enolates have been successfully isolated and crystallographically characterized.

  13. Parásitos intestinales en monos congo Alouatta palliata (Primates: Cebidae de Costa Rica

    Directory of Open Access Journals (Sweden)

    Misael Chinchilla Carmona

    2005-09-01

    Full Text Available Se estudiaron las heces de 102 monos de la especie Alouatta palliata (monos aulladores o congos de las siguientes regiones de Costa Rica. Valle Central: San Ramón (Alajuela; Pacífico Central: Isla Chira y Parque Manuel Antonio (Puntarenas; Pacífico Norte: Palo Verde, Playa Potrero, Nicoya (Guanacaste y Caribe: Cahuita (Limón. Los animales capturados fueron anestesiados con dardos conteniendo Telazol®. La mayoría defecaron espontáneamente o se les estimulaba a defecar. Las muestras se estudiaron en el laboratorio en forma directa en solución salina (0.85% y una solución de yodo o teñidas con hematoxilina para identificar los parásitos correspondientes. El material fue cultivado en el medio de Dobell para determinar la presencia de amebas y flagelados. Se encontraron helmintos de los géneros Trypanoxyuris, Strongyloides y Controrchis y protozoarios de los géneros Endolimax, Entamoeba, Trichomonas y Giardia. Los porcentajes de infección por protozoarios oscilaron entre 16.7% y 80% y se encontraron helmintos en un 3.4% a un 80% de los animales de acuerdo con la zona estudiada. No se encontraron diferencias importantes de parasitosis relacionadas con el sexo pero si existió mayor infección en los animales más jóvenes. Se establece la relación entre los índices de infección y algunos parámetros tales como las áreas estudiadas, el peso de los animales y el contacto con el ser humano.Intestinal parasites in howler monkeys Alouatta palliata (Primates: Cebidae of Costa Rica. Fecal samples of 102 howler monkeys (Alouatta palliata from several sites of Costa Rica were studied for intestinal parasites. The zones studied were: Central Valley (San Ramón, Alajuela, Central Pacific (Chomes and Manuel Antonio National Park, Puntarenas, North Pacific (Palo Verde Park and Playa Potrero, Guanacaste, Chira Island in the Nicoya Gulf and Caribean area (Cahuita, Limón. Animals were anesthetized with dards containing Telazol in order to collect

  14. A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits

    OpenAIRE

    Marum, Ana Paula; Moreira, Cátia; Tomas-Carus, Pablo; Saraiva, Fernando; Guerreiro, Catarina Sousa

    2017-01-01

    Introduction: Fibromyalgia is a chronic rheumatic disease producing widespread pain, associated to a major comorbidity -irritable bowel syndrome. Low FODMAPS diet (low fermentable oligo-di-mono-saccharides and polyols diet) has been effective in controlling irritable bowel syndrome symptoms. Overweight is an aggravating factor for fibromyalgia. We studied effects of low fermentable oligo-di-mono-saccharides and polyols diets on fibromyalgia symptoms and weight status. Methods: A longitudinal ...

  15. Relationship between mono-hydroxy-carbazepine serum concentrations and adverse effects in patients on oxcarbazepine monotherapy.

    Science.gov (United States)

    Sattler, Annika; Schaefer, Marion; May, Theodor W

    2015-09-01

    To evaluate the relationship between serum concentrations of mono-hydroxy-carbazepine (MHD), the main metabolite of oxcarbazepine (OXC), and the occurrence of adverse effects (AE) in a large group of patients on OXC monotherapy. An antiepileptic drug (AED) therapeutic drug monitoring (TDM) database was analyzed especially with regard to OXC dosage, MHD serum concentration, and the occurrence of AE. In total, 893 blood samples of 442 patients were included in this retrospective study. The statistical evaluation was performed by means of Kaplan-Meier estimates, log-rank tests and generalized estimating equations (GEE). At least one AE was reported in 78 (17.6%) of the 442 patients. At MHD serum concentrations of 30.0 μg/ml and 43.7 μg/ml and OXC dosages of 33.1 mg/kg and 62.3 mg/kg, 25% and 75% of patients, respectively, experienced at least one AE. Log-rank tests indicated that younger patients (<18 years) may be able to tolerate higher MHD serum levels (p = 0.006) and higher OXC dosages per body weight (p < 0.001) compared to adult patients (≥ 18 years). Furthermore, AEs occurred at higher body-weight adjusted OXC dosages of extended release formulations compared to immediate-release formulations (p = 0.010), whereas MHD serum levels at which AEs occurred did not differ significantly between formulations (p = 0.125). Multivariate GEE confirmed the results. The occurrence of AEs is significantly (and non-linearly) dependent on MHD serum level, whereas the dependence of OXC dosage is less distinctive. But, tolerability of OXC seems to depend on age of the patients as well as on pharmaceutical formulation of OXC. Copyright © 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  16. Electro-spray of high viscous liquids for producing mono-sized spherical alginate beads

    Institute of Scientific and Technical Information of China (English)

    Hamid Moghadam; Mohsen Samimi; Abdolreza Samimi; Mohamad Khorram

    2008-01-01

    Alginate beads, often used for controlled release of enzymes and drugs, are usually produced by spraying sodium alginate liquid into a gelling agent using mechanical vibration nozzle or air jet. In this work an alternative method of electro-spray was employed to form droplets with desired size from a highly viscous sodium alginate solution using constant DC voltage. The droplets were then cured in a calcium chloride solution. The main objective was to produce mono-sized beads from such a highly viscous and non-Newtonian liquid (1000-5000 mPa s). The effects of nozzle diameter, flow rate and concentration of liquid on the size of the beads were investigated. Among the parameters studied, voltage had a pronounced effect on the size of beads as compared to flow rate zzle diameter and concentration of alginate liquid. The size of beads was reduced to a minimum value with increasing the voltage in the range of 0-10 kV. At the early stages of voltage increase (I.e. Up to about 4 kV), the rate of size reduction was relatively low, while the dripping mode dominated. However, in the middle part of the range of applied voltage, where the rate of size reduction was high (I.e. About 4-7 kV), an unstable transition occurred between dripping and jetting. At the end part of the range (I.e. 7-10 kV) jet mode of spray was observed. Increasing the height of fall of the droplets was found to improve the sphericity of the beads, because of the increased time of flight for the droplets. This was especially identifiable at higher concentrations of the alginate liquid (I.e. 3 w/v%)

  17. Carotid Angioplasty In Octogenarians: A Mono-Arm Trial With Clinical And Angiographic Follow Up

    Directory of Open Access Journals (Sweden)

    Ehsan Sharifipour

    2017-02-01

    Full Text Available Background: Octogenarians account for a third of ischemic stroke (IS patients and they have higher morbidity and mortality rate among IS patients. The aim of this study was to evaluate the pri-procedural and long term clinical and angiographic statement of carotid artery angioplasty (CAA in octogenarians. Methods: In a mono-arm trial 102 patients>80 years old with symptomatic internal carotid artery (ICA stenosis presented by non-disabling IS or TIA underwent the CAA and were evaluated prospectively from January 2010 to July 2014. All patients had standard stroke care during the study follow up. The peri-procedural complications, cerebrovascular accidents, restenosis in target vessel and mortality rate were recorded to evaluate safety and durability of this secondary stroke prevention method in octogenarians. Results: 48 (47.06% males and 54 (52.9% females in a mean period of 24.5±14.1 (6-50 months were followed. For all patients mean age was 83.39 ±2.53 (range, 80-88 years. The success rate of CAA was 100%, whereas the peri-procedural complication rate was 5.8% (access-site local hematoma and bradycardia during CAA both in 2.94%.There was only one patient who had acute ischemic stroke during the procedure. Restenosis occurred in 3.9% after a mean of 21.5 months. The proportion of recurrent cerebrovascular accident was 9.8% while TIAs occurred in 3.9% and stroke in 1% of patients. Also 4.9% of patients experienced coronary artery disease and the proportion of fatal recurrent cerebrovascular accident was 2.9%.  The median patient event-free survival was 20 months. Conclusion: CAA seems to be a safe and durable IS secondary prevention method in octogenarians with symptomatic carotid artery stenosis.

  18. Antioxidant effect of mono- and dihydroxyphenols in sunflower oil with different levels of naturally present tocopherols

    Science.gov (United States)

    Hrádková, Iveta; Merkl, Roman; Šmidrkal, Jan; Kyselka, Jan; Filip, Vladimír

    2013-01-01

    Antioxidant properties of mono- and dihydroxyphenolic acids and their alkyl esters were examined, with emphasis on the relationship between their molecular structure and antioxidant activity. Test media with different tocopherol level were used for determining the oxidative stability: original refined sunflower oil (total tocopherols 149.0 mg/kg), partially tocopherol-stripped sunflower oil (total tocopherols 8.7 mg/kg) and distilled fatty acid methyl esters (FAME) as a tocopherol-free medium. The chemical reaction of tocopherols with diazomethane tested for the purpose to eliminate their antioxidant activity failed due to the negligible degree of methylation of hydroxyl group in the tocopherol molecule. Caffeic acid and protocatechuic acid (3,4-dihydroxyphenolic acids) and their alkyl esters were found to be more active antioxidants than monohydroxyphenolic acid (p-hydroxybenzoic acid), 2,5-dihydroxyphenolic acid (gentisic acid), 3-methoxy-4-hydroxyphenolic acids (vanillic and ferulic acids) and their corresponding alkyl esters. Naturally present tocopherols in refined sunflower oil proved to have a synergistic effect on gentisic acid but not on its alkyl esters. In contrast, tocopherols showed an antagonistic effect on alkyl esters of caffeic acid, because their protection factors decreased with increasing level of tocopherols in the test medium. Moreover, the antioxidant activity of these alkyl esters decreased with increasing length of their alkyl chain in conformity with the polar paradox hypothesis. Practical applications: Tocopherols as naturally present antioxidants influence considerably the antioxidant activity of other antioxidants added to plant oils used as a test medium. Distilled fatty acid methyl esters prepared from refined sunflower oil may serve as an optimal tocopherol-free test medium. Some alkyl esters of phenolic acids were evaluated to be applicable as natural more lipophilic antioxidants in comparison with phenolic acids. PMID:23997655

  19. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

    International Nuclear Information System (INIS)

    Tetz, Lauren M.; Cheng, Adrienne A.; Korte, Cassandra S.; Giese, Roger W.; Wang, Poguang; Harris, Craig; Meeker, John D.; Loch-Caruso, Rita

    2013-01-01

    Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is linked to the pathology of adverse pregnancy outcomes, effects of DEHP metabolites, including the active metabolite, mono-2-ethylhexyl phthalate (MEHP), on oxidative stress responses in placental cells have not been previously evaluated. The objective of the current study is to identify MEHP-stimulated oxidative stress responses in human placental cells. We treated a human placental cell line, HTR-8/SVneo, with MEHP and then measured reactive oxygen species (ROS) generation using the dichlorofluorescein assay, oxidized thymine with mass-spectrometry, redox-sensitive gene expression with qRT-PCR, and apoptosis using a luminescence assay for caspase 3/7 activity. Treatment of HTR-8 cells with 180 μM MEHP increased ROS generation, oxidative DNA damage, and caspase 3/7 activity, and resulted in differential expression of redox-sensitive genes. Notably, 90 and 180 μM MEHP significantly induced mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2), an enzyme important for synthesis of prostaglandins implicated in initiation of labor. The results from the present study are the first to demonstrate that MEHP stimulates oxidative stress responses in placental cells. Furthermore, the MEHP concentrations used were within an order of magnitude of the highest concentrations measured previously in human umbilical cord or maternal serum. The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes. - Highlights: ► MEHP increased reactive oxygen species, oxidative DNA damage, and caspase activity. ► MEHP induced expression of PTGS2, a gene

  20. Biodegradation of mono-chlorobenzene by using a trickle bed air biofilter (TBAB).

    Science.gov (United States)

    Mathur, Anil K; Majumder, C B; Singh, Dhananjay; Bala, Shashi

    2010-07-01

    In the present study, performance of the trickle bed airbiofilter (TBAB) for treating mono-chlorobenzene (MCB) was evaluated for various influent volatile organic compound (VOC) loadings using coal and mixed consortium of activated sludge as the packing material. Microbial acclimation to MCB was achieved by exposing the system continuously for 31 d to an average inlet MCB concentration of 0.688 g m(-3) at an empty bed residence time (EBRT) of 188 s. The TBAB achieved maximum removal efficiency of 87% at an EBRT of 188 s for an inlet concentration of 0.681 g m(-3), which is quite significance than the values reported in the literature. Elimination capacities of MCB increased with an increase of the influent VOC loading, but an opposite trend was observed for the removal efficiency The maximum elimination capacity of the biofilter was 110.75 g m(-3) hr(-1) at an inlet MCB concentration of 1.47 g m(-3). The effect of starvation on the TBAB was also studied. After starvation, the TBAB lost its ability to degrade MCB initially However the biofilter recovered very quickly Evaluation of the concentration profile along the bed height indicated that the bottom section of TBAB has the best performance for all concentrations. By using Wani's method of macrokinetic determination based on simple Monod kinetics, the maximum removal rate of MCB, r(max) and saturation constant K(m) was to be found as 1.304 g m(-3)s(-1) and 113.446 g m(-3), respectively.

  1. Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population.

    Science.gov (United States)

    Chen, Szu-Ying; Hwang, Jing-Shiang; Sung, Fung-Chang; Lin, Chien-Yu; Hsieh, Chia-Jung; Chen, Pau-Chung; Su, Ta-Chen

    2017-06-01

    Phthalates are commonly used as plasticizers and are reported to associate with testicular dysfunction or insulin resistance in different studies, but the concurrent relationship between phthalate exposure, testosterone levels, and insulin resistance in the young population is not well understood. We recruited 786 subjects aged 12-30 years from a population-based sample of Taiwanese adolescents and young adults from 2006 to 2008. Generalized additive models were used to evaluate glucose homeostasis and testicular function in relation to seven urinary phthalate metabolites among adolescents (aged 12-20) and young adults (aged 20-30) in Taiwan. We observed a trend toward a decrease in male testosterone and an increase in urinary mono-2-ethylhexyl phthalate (MEHP) levels across four quartiles of homeostasis model assessment of insulin resistance (HOMA-IR). After adjusting for potential covariates, generalized additive models further showed that log-transformed insulin and HOMA-IR were raised by 0.055 [95% confidence interval (CI), 0.027-0.082] and 0.056 (95% CI, 0.027-0.084), respectively, with a one-unit increase in log-transformed MEHP in young adults. In male adults (aged 22-30), the log-testosterone levels were reduced by 0.018 (95% CI, 0.001-0.036), with a one-unit of increase in log-transformed MEHP. Such relationships were not observed in adolescents. In conclusion, this study demonstrated age-related associations of urinary MEHP metabolites with impaired metabolic homeostasis of glucose that were only observed in young adults. In addition, MEHP exposure was concurrently associated with lower testosterone levels in young, male adults. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Laboratory investigations on continuous bio-methanization of energy crops as mono-substrate without supplementation

    International Nuclear Information System (INIS)

    Demirel, Burak

    2009-01-01

    Continuous bio-methanization of an energy crop, namely the beet silage, was investigated in this laboratory-scale work as mono-substrate, using a mesophilic biogas digester controlled by a fuzzy logic control (FLC) technique and without using any supplementing or buffering agent, despite the low pH of the substrate around 3.80. The temperature, pH, redox potential (ORP), daily biogas production and composition of digester biogas were continuously measured online. During the operation, the hydraulic retention time (HRT) varied between 24.8 and 9 days, as the organic loading rate (OLR) ranged from 2.6 to 4.7 g L -1 d -1 . The average pH, specific gas production rate (spec. GPR) and volumetric gas production rate (vol. GPR) were determined to be 7.12, 0.31 L g VS -1 d -1 and 1.084 L L -1 d -1 , respectively. The average methane (CH 4 ) content of digester biogas was about 56%. The FLC technique, which was developed at HAW Hamburg for anaerobic conversion of acidic energy crops to methane, determined the daily feeding volume (∼ OLR/HRT) for the biogas digester, depending on the feedback from online pH and methane measurements, and on the calculation of the spec. GPR. The spec. GPR was calculated by the corrected daily biogas production. Through online monitoring of pH, biogas production rate and composition, and by use of the FLC technique, the acidic beet silage could continuously be converted to biogas, without using manure or any other kind of buffering or supplementing agent(s). The lab-scale anaerobic biogas digester performed stable and safe, without encountering any problems of instability, as indicated by an adequate amount of buffering capacity, a VFA content below 0.5 g L -1 and a neutral pH range throughout the study.

  3. Spatial analyses of mono, di and trinucleotide trends in plant genes.

    Directory of Open Access Journals (Sweden)

    Andrea Porceddu

    Full Text Available Genomic DNA sequences display compositional heterogeneity on many scales. In this paper we analyzed tendencies and anomalies in the occurence of mono, di and trinucleotides in structural regions of plant genes. Representation of these trends as a function of position along genic sequences highlighted compositional features peculiar of either monocots or eudicots that were remarkably uniform within these two evolutionary clades. The most evident of these features appeared in the form of gradient of base content along the direction of transcription. The robustness of such a representation was validated in sequences sub-datasets generated considering structural and compositional features such as total length of cds, overall GC content and genic orientation in the genome. Piecewise regression analyses indicated that the gradients could be conveniently approximated to a two segmented model where a first region featuring a steep slope is followed by a second segment fitting a milder variation. In general, monocots species showed steeper segments than eudicots. The guanine gradient was the most distinctive feature between the two evolutionary clades, being moderately increasing in eudicots and firmly decreasing in monocots. Single gene investigation revealed that a high proportion of genes show compositional trends compatible with a segmented model suggesting that these features are essential attributes of gene organization. Dinucleotide and trinucleotide biases were referred to expectation based on a random union of the component elements. The average bias at dinucleotide level identified a significant undererpresentation of some dinucleotide and the overrepresention of others. The bias at trinucleotide level was on average low. Finally, the analysis of bryophyte coding sequences showed mononucleotide, dinucleotide and trinucleotide compositional trends resembling those of higher plants. This finding suggested that the emergenge of compositional bias

  4. Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells

    International Nuclear Information System (INIS)

    Reinsberg, Jochen; Wegener-Toper, Petra; Ven, Katrin van der; Ven, Hans van der; Klingmueller, Dietrich

    2009-01-01

    The phthalate ester mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of di-(2-ethylhexyl) phthalate, a high-production-volume chemical used as a plasticizer and solvent in numerous consumer products. MEHP has been demonstrated to be a reproductive toxicant in rodents decreasing estradiol and progesterone production in preovulatory granulosa cells. In the present study, we examined the effect of MEHP on steroid production of human granulosa-lutein (GL) cells. Human GL cells collected from women undergoing in vitro fertilization were cultured in medium containing FSH, hCG and 8-Br-cAMP, respectively, together with various concentrations of MEHP (0-500 μmol L -1 ). After incubation for 48 h estradiol and progesterone were assayed in the spent culture medium. Furthermore, aromatase activity and mRNA levels of GL cells were determined. Basal as well as FSH-, hCG- and 8-Br-cAMP-stimulated estradiol production of GL cells was suppressed by MEHP in a dose-dependent manner (IC 50 = 105 μmol L -1 , 138 μmol L -1 , 49 μmol L -1 and 78 μmol L -1 ). Furthermore aromatase activity and mRNA levels were reduced in GL cells cultured with MEHP. In contrast, MEHP did not alter the production of progesterone up to a concentration of 167 μmol L -1 . The present data indicate that MEHP is a specific inhibitor of estradiol production in human GL cells with a post-cAMP site of action. The inhibition of estradiol production obviously results from a reduction of aromatase activity on the transcript level. As the in vitro effective doses of MEHP are within the range of real environmental exposure levels an inhibitory effect on estrogen production in vivo seems to be possible.

  5. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Tetz, Lauren M., E-mail: ltetz@umich.edu [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Cheng, Adrienne A.; Korte, Cassandra S. [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Giese, Roger W.; Wang, Poguang [Department of Pharmaceutical Sciences, Northeastern University, 360 Huntingon Ave, Boston, MA 02115 (United States); Harris, Craig; Meeker, John D.; Loch-Caruso, Rita [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States)

    2013-04-01

    Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is linked to the pathology of adverse pregnancy outcomes, effects of DEHP metabolites, including the active metabolite, mono-2-ethylhexyl phthalate (MEHP), on oxidative stress responses in placental cells have not been previously evaluated. The objective of the current study is to identify MEHP-stimulated oxidative stress responses in human placental cells. We treated a human placental cell line, HTR-8/SVneo, with MEHP and then measured reactive oxygen species (ROS) generation using the dichlorofluorescein assay, oxidized thymine with mass-spectrometry, redox-sensitive gene expression with qRT-PCR, and apoptosis using a luminescence assay for caspase 3/7 activity. Treatment of HTR-8 cells with 180 μM MEHP increased ROS generation, oxidative DNA damage, and caspase 3/7 activity, and resulted in differential expression of redox-sensitive genes. Notably, 90 and 180 μM MEHP significantly induced mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2), an enzyme important for synthesis of prostaglandins implicated in initiation of labor. The results from the present study are the first to demonstrate that MEHP stimulates oxidative stress responses in placental cells. Furthermore, the MEHP concentrations used were within an order of magnitude of the highest concentrations measured previously in human umbilical cord or maternal serum. The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes. - Highlights: ► MEHP increased reactive oxygen species, oxidative DNA damage, and caspase activity. ► MEHP induced expression of PTGS2, a gene

  6. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl phthalate (MEHP.

    Directory of Open Access Journals (Sweden)

    Wenhui Zhai

    Full Text Available Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting in widespread distribution in aquatic environments. However, limited information is available on the endocrine disrupting effects of phthalates in aquatic organisms. The aim of the present study was to examine whether exposure to mono-(2-ethylhexyl phthalate (MEHP, the hydrolytic metabolite of di-(2-ethylhexyl phthalate (DEHP disrupts thyroid endocrine system in fish. In this study, zebrafish (Danio rerio embryos were exposed to different concentrations of MEHP (1.6, 8, 40, and 200 μg/L from 2 h post-fertilization (hpf to 168 hpf. The whole-body content of thyroid hormone and transcription of genes involved in the hypothalamic-pituitary-thyroid (HPT axis were examined. Treatment with MEHP significantly decreased whole-body T4 contents and increased whole-body T3 contents, indicating thyroid endocrine disruption. The upregulation of genes related to thyroid hormone metabolism (Dio2 and UGT1ab might be responsible for decreased T4 contents. Elevated gene transcription of Dio1 was also observed in this study, which might assist to degrade increased T3 contents. Exposure to MEHP also significantly induced transcription of genes involved in thyroid development (Nkx2.1 and Pax8 and thyroid hormone synthesis (TSHβ, NIS and TG. However, the genes encoding proteins involved in TH transport (transthyretin, TTR was transcriptionally significantly down-regulated after exposure to MEHP. Overall, these results demonstrate that acute exposure to MEHP alters whole-body contents of thyroid hormones in zebrafish embryos/larvae and changes the transcription of genes involved in the HPT axis, thus exerting thyroid endocrine toxicity.

  7. Strong ligand field effects of blue phosphorescent mono-cyclometalated iridium(III) complexes

    International Nuclear Information System (INIS)

    Ham, Ho Wan; Jung, Kyung Yoon; Kim, Young Sik

    2010-01-01

    A series of mono-cyclometalated blue phosphorescent iridium(III) complexes with two phosphines trans to each other and two cis-ancillary ligands, such as Ir(F 2 Meppy)(PPhMe 2 ) 2 (H)(Cl), [Ir(F 2 Meppy)(PPhMe 2 ) 2 (H)(NCMe)] + and Ir(F 2 Meppy)(PPhMe 2 ) 2 -(H)(CN), [F 2 Meppy = 2-(2',4'-difluorophenyl)-4-methyl-pyridine] were synthesized and studied to tune the phosphorescence wavelength to the deep blue region and to enhance the luminescence efficiencies. We investigate the electron-withdrawing capabilities of ancillary ligands using the DFT and TD-DFT calculations on the ground and excited states of the three complexes to gain insight into the factors responsible for the emission color change and the different luminescence efficiency. Reducing the molecular weight of phosphine ligand with PPhMe 2 leads to a strategy of the efficient deep blue organic light-emitting devices (OLED) by thermal processing instead of the solution processing. The electron-withdrawing difluoro group substituted on the phenyl ring and the cyano strong field ancillary ligand in the trans position to the carbon atom of phenyl ring increased HOMO-LUMO gap and achieved the hypsochromic shift in emission color. As a result, the maximum emission spectra of Ir(F 2 Meppy)(PPhMe 2 ) 2 (H)(Cl), [Ir(F 2 Meppy)(PPhMe 2 ) 2 (H)-(NCMe)] + and Ir(F 2 Meppy)(PPh-Me 2 ) 2 (H)(CN) were in the ranges of 446, 440, 439 nm, respectively.

  8. Strong ligand field effects of blue phosphorescent mono-cyclometalated iridium(III) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Ham, Ho Wan [Department of Information Display, Hongik University, Seoul, 121-791 (Korea, Republic of); Jung, Kyung Yoon [International Design School for Advanced Studies, Hongik University, Seoul 121-791 (Korea, Republic of); Kim, Young Sik, E-mail: youngkim@hongik.ac.k [Department of Information Display, Hongik University, Seoul, 121-791 (Korea, Republic of)

    2010-09-01

    A series of mono-cyclometalated blue phosphorescent iridium(III) complexes with two phosphines trans to each other and two cis-ancillary ligands, such as Ir(F{sub 2}Meppy)(PPhMe{sub 2}){sub 2}(H)(Cl), [Ir(F{sub 2}Meppy)(PPhMe{sub 2}){sub 2}(H)(NCMe)]{sup +} and Ir(F{sub 2}Meppy)(PPhMe{sub 2}){sub 2}-(H)(CN), [F{sub 2}Meppy = 2-(2',4'-difluorophenyl)-4-methyl-pyridine] were synthesized and studied to tune the phosphorescence wavelength to the deep blue region and to enhance the luminescence efficiencies. We investigate the electron-withdrawing capabilities of ancillary ligands using the DFT and TD-DFT calculations on the ground and excited states of the three complexes to gain insight into the factors responsible for the emission color change and the different luminescence efficiency. Reducing the molecular weight of phosphine ligand with PPhMe{sub 2} leads to a strategy of the efficient deep blue organic light-emitting devices (OLED) by thermal processing instead of the solution processing. The electron-withdrawing difluoro group substituted on the phenyl ring and the cyano strong field ancillary ligand in the trans position to the carbon atom of phenyl ring increased HOMO-LUMO gap and achieved the hypsochromic shift in emission color. As a result, the maximum emission spectra of Ir(F{sub 2}Meppy)(PPhMe{sub 2}){sub 2}(H)(Cl), [Ir(F{sub 2}Meppy)(PPhMe{sub 2}){sub 2}(H)-(NCMe)]{sup +} and Ir(F{sub 2}Meppy)(PPh-Me{sub 2}){sub 2} (H)(CN) were in the ranges of 446, 440, 439 nm, respectively.

  9. Shock-induced microstructural response of mono- and nanocrystalline SiC ceramics

    Science.gov (United States)

    Branicio, Paulo S.; Zhang, Jingyun; Rino, José P.; Nakano, Aiichiro; Kalia, Rajiv K.; Vashishta, Priya

    2018-04-01

    The dynamic behavior of mono- and nanocrystalline SiC ceramics under plane shock loading is revealed using molecular-dynamics simulations. The generation of shock-induced elastic compression, plastic deformation, and structural phase transformation is characterized at different crystallographic directions as well as on a 5-nm grain size nanostructure at 10 K and 300 K. Shock profiles are calculated in a wide range of particle velocities 0.1-6.0 km/s. The predicted Hugoniot agree well with experimental data. Results indicate the generation of elastic waves for particle velocities below 0.8-1.9 km/s, depending on the crystallographic direction. In the intermediate range of particle velocities between 2 and 5 km/s, the shock wave splits into an elastic precursor and a zinc blende-to-rock salt structural transformation wave, which is triggered by shock pressure over the ˜90 GPa threshold value. A plastic wave, with a strong deformation twinning component, is generated ahead of the transformation wave for shocks in the velocity range between 1.5 and 3 km/s. For particle velocities greater than 5-6 km/s, a single overdriven transformation wave is generated. Surprisingly, shocks on the nanocrystalline sample reveal the absence of wave splitting, and elastic, plastic, and transformation wave components are seamlessly connected as the shock strength is continuously increased. The calculated strengths 15.2, 31.4, and 30.9 GPa for ⟨001⟩, ⟨111⟩, and ⟨110⟩ directions and 12.3 GPa for the nanocrystalline sample at the Hugoniot elastic limit are in excellent agreement with experimental data.

  10. Gps monitoring of the la valette landslide (french alps) with two mono-frequency receivers

    Science.gov (United States)

    Squarzoni, C.; Delacourt, C.; Allemand, P.

    2003-04-01

    In the last years, the Global Positioning System techniques have been more and more employed in landslide monitoring. Here we present an application of the GPS techniques on the La Valette landslide, located in the Ubaye Valley in the southern French Alps. This complex landslide is composed by an upper part affected essentially by rotational mechanism, a central part with a generally translational movement and a lower part, occasionally transforming in mud flow in coincidence with strong rainfall events. Displacement rates are in average of a few centimetres per month and can reach one centimetre per day during spring. GPS data presented in this study have been acquired with a couple of mono-frequency GPS receivers Magellan ProMARK X-CM associated with multipath-resistant antennas and processed with the Magellan post-processing software MSTAR. Nine points have been set in the whole zone, seven of them in the moving area, one in a stable area near the landslide and one on the facing slope, used as reference point. For each measure, one GPS receiver is placed on the base point and the second one is placed on each monitored point for one-hour sessions. The baseline between base and monitored point ranges from 480 and 1660 m. Nine campaigns of measure have been made between October 2000 and October 2002, to follow the evolution of the surface displacements. The GPS results have been compared with the distance-meter measurements achieved on the same site by RTM Service (Restauration des Terrains de Montagne). The velocities obtained by the two methods are similar. The advantage of the GPS technique is the obtention of the real 3D displacement vector. These measurements have been combined with SAR interferometric data in order to derive a 3D map of the deformation.

  11. Biofilm Structures in a Mono-Associated Mouse Model of Clostridium difficile Infection

    Directory of Open Access Journals (Sweden)

    Anna P. Soavelomandroso

    2017-10-01

    Full Text Available Clostridium difficile infection (CDI is a major healthcare-associated disease with high recurrence rates. Host colonization is critical for the infectious process, both in first episodes and in recurrent disease, with biofilm formation playing a key role. The ability of C. difficile to form a biofilm on abiotic surfaces is established, but has not yet been confirmed in the intestinal tract. Here, four different isolates of C. difficile, which are in vitro biofilm producers, were studied for their ability to colonize germ-free mice. The level of colonization achieved was similar for all isolates in the different parts of the murine gastrointestinal tract, but pathogen burden was higher in the cecum and colon. Confocal laser scanning microscopy revealed that C. difficile bacteria were distributed heterogeneously over the intestinal tissue, without contact with epithelial cells. The R20291 strain, which belongs to the Ribotype 027 lineage, displayed a unique behavior compared to the other strains by forming numerous aggregates. By immunochemistry analyses, we showed that bacteria were localized inside and outside the mucus layer, irrespective of the strains tested. Most bacteria were entrapped in 3-D structures overlaying the mucus layer. For the R20291 strain, the cell-wall associated polysaccharide PS-II was detected in large amounts in the 3-D structure. As this component has been detected in the extrapolymeric matrix of in vitro C. difficile biofilms, our data suggest strongly that at least the R20291 strain is organized in the mono-associated mouse model in glycan-rich biofilm architecture, which sustainably maintains bacteria outside the mucus layer.

  12. Novel design concepts for generating intense accelerator based beams of mono-energetic fast neutrons

    International Nuclear Information System (INIS)

    Franklyn, C.B.; Govender, K.; Guzek, J.; Beer, A. de; Tapper, U.A.S.

    2001-01-01

    Full text: Successful application of neutron techniques in research, medicine and industry depends on the availability of suitable neutron sources. This is particularly important for techniques that require mono-energetic fast neutrons with well defined energy spread. There are a limited number of nuclear reactions available for neutron production and often the reaction yield is low, particularly for thin targets required for the production of mono-energetic neutron beams. Moreover, desired target materials are often in a gaseous form, such as the reactions D(d,n) 3 He and T(d,n) 3 He, requiring innovative design of targets, with sufficient target pressure and particle beam handling capability. Additional requirements, particularly important in industrial applications, and for research institutions with limited funds, are the cost effectiveness as well as small size, coupled with reliable and continuous operation of the system. Neutron sources based on high-power, compact radio-frequency quadrupole (RFQ) linacs can satisfy these criteria, if used with a suitable target system. This paper discusses the characteristics of a deuteron RFQ linear accelerator system coupled to a high pressure differentially pumped deuterium target. Such a source, provides in excess of 10 10 mono- energetic neutrons per second with minimal slow neutron and gamma-ray contamination, and is utilised for a variety of applications in the field of mineral identification and materials diagnostics. There is also the possibility of utilising a proposed enhanced system for isotope production. The RFQ linear accelerator consists of: 1) Deuterium 25 keV ion source injector; 2) Two close-coupled RFQ resonators, each powered by an rf amplifier supplying up to 300 kW of peak power at 425 MHz; 3) High energy beam transport system consisting of a beam line, a toroid for beam current monitoring, two steering magnets and a quadrupole triplet for beam focusing. Basic technical specifications of the RFQ linac

  13. 143 - 148_Makeri et al.

    African Journals Online (AJOL)

    USER

    2015-06-01

    Jun 1, 2015 ... Yuan et al., 2003), antimicrobial activity (Sundarrao et al., 1993; Betancur-Galvis et al., 1999; Takashi et al., 2006), anti-parasitic, anti-malarial activities (Alali et al., 1998; Jaramillo et al., 2000; Luna et al.,. 2005). This study evaluates the antibacterial activity of extract of stem –bark and leaf extracts of Annona.

  14. Abu al-Layth al-Libi

    Science.gov (United States)

    2015-02-01

    success. As an Arab participant acknowledged very early on, “the situation was really harsh. All the brothers were tired,” as they lacked food and... glorious battles that occurred during the early Islamic period.133 He stressed the importance of the battlefield as the path to achieve honor and dignity...diaspora in Waziristan. In the words of Walid Othmani, a French jihadi trained by al-Qa`ida in Waziristan in 2008, “[Al-Libi] was someone well-known and

  15. Pornographie als Metapher

    Directory of Open Access Journals (Sweden)

    Caroline Schubarth

    2010-02-01

    Full Text Available In diesem Artikel werden unterschiedliche metaphorische Verwendungen des Pornografiebegriffs und deren Implikationen untersucht. Während die Existenz von Pornografie der feministischen Anti-Porno-Bewegung als Erklärung für die anhaltende Diskriminierung von Frauen in westlichen Gesellschaften dient, nutzen rechtskonservative Kräfte den Pornografievorwurf als Rechtfertigung für die Zensur von als deviant empfundenen Identitäten und sexuellen Praktiken.

  16. Method development for the determination of fluorine in toothpaste via molecular absorption of aluminum mono fluoride using a high-resolution continuum source nitrous oxide/acetylene flame atomic absorption spectrophotometer.

    Science.gov (United States)

    Ozbek, Nil; Akman, Suleyman

    2012-05-30

    Fluorine was determined via the rotational molecular absorption line of aluminum mono fluoride (AlF) generated in C(2)H(2)/N(2)O flame at 227.4613 nm using a high-resolution continuum source flame atomic absorption spectrophotometer (HR-CS-FAAS). The effects of AlF wavelength, burner height, fuel rate (C(2)H(2)/N(2)O) and amount of Al on the accuracy, precision and sensitivity were investigated and optimized. The Al-F absorption band at 227.4613 nm was found to be the most suitable analytical line with respect to sensitivity and spectral interferences. Maximum sensitivity and a good linearity were obtained in acetylene-nitrous oxide flame at a flow rate of 210 L h(-1) and a burner height of 8mm using 3000 mg L(-1) of Al for 10-1000 mg L(-1)of F. The accuracy and precision of the method were tested by analyzing spiked samples and waste water certified reference material. The results were in good agreement with the certified and spiked amounts as well as the precision of several days during this study was satisfactory (RSD<10%). The limit of detection and characteristic concentration of the method were 5.5 mg L(-1) and 72.8 mg L(-1), respectively. Finally, the fluorine concentrations in several toothpaste samples were determined. The results found and given by the producers were not significantly different. The method was simple, fast, accurate and sensitive. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Obtention of Samarium and Gadolinium concentrates by solvent extraction using mono-2-ethylhexyl ester of 2-ethylhexyl phosphonic acid; Obtencao de concentrados de samario e gadolinio via extracao por solventes com o ester mono-2-etilhexil do acido 2-etilhexilfosfonico

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, Junior, Pedro

    1996-07-01

    The rare earth chlorides solution employed in this study, which is constituted by medium and heavy fractions, is derived from monazite processing accomplished by NUCLEMON-Mineroquimica (SP). This solution shows an acidity about 1.18 M and 189 g/L of rare earth oxides, containing as main constituents: Sm(34.55%), Gd(23.85%), Dy (6.82%), and Y (24.45%). It was used, as organic phase, 2-ethylhexyl phosphonic acid, mono-2-ethylhexylester diluted to 1 M in isododecane. (author)

  18. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Directory of Open Access Journals (Sweden)

    Musso CG

    2006-03-01

    Full Text Available RESUMEN:La insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia.En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal. SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one.In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  19. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Directory of Open Access Journals (Sweden)

    Musso CG

    2007-04-01

    Full Text Available RESUMENLa insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia. En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal.SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one. In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  20. Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype.

    Science.gov (United States)

    Bhardwaj, Suvercha; Ahmad, Fareed; Wedemeyer, Heiner; Cornberg, Marcus; Schulze Zur Wiesch, Julian; van Lunzen, Jan; Sarin, Shiv K; Schmidt, Reinhold E; Meyer-Olson, Dirk

    2016-04-18

    HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infection has been a relatively under-investigated area. Natural killer (NK) cells are pivotal sentinels of innate immunity against viruses and tumour cells. In this study we evaluated the effect of HIV-HCV co-infection on peripheral blood NK cell subsets with emphasis on the phenotype of CD56(bright) NK cells. Sixty patients were included in the study; HIV mono-infected (n = 12), HCV mono-infected (n = 15), HCV-HIV co-infected (n = 21) and healthy controls (n = 16). PBMCs were isolated and immunophenotyping of NK cells was performed by flowcytometry. We observed an expansion of CD56(bright) NK cell subset in HIV-HCV co-infection as compared to healthy controls and HIV mono-infected group. All the infected groups had an upregulated expression of the activating receptor NKG2D on CD56(bright) NK cells in comparison to healthy controls while not differing amongst themselves. The expression of NKp46 in HIV-HCV co-infected group was significantly upregulated as compared to both HIV as well as HCV mono-infections while NKp30 expression in the HIV-HCV co-infected group significantly differed as compared to HIV mono-infection. The CD56(bright) NK cell subset was activated in HIV-HCV co-infection as assessed by the expression of CD69 as compared to healthy controls but was significantly downregulated in comparison to HIV mono-infection. CD95 expression on CD56(bright) NK cells followed the same pattern where there was an increased expression of CD95 in HIV mono-infection and HIV-HCV co-infection as compared to healthy controls. In contrast to CD69 expression, CD95 expression in HCV mono-infection was decreased when compared to HIV mono-infection and HIV-HCV co-infection. Finally, expression of CXCR3 on CD56(bright) NK cells was increased in HIV-HCV co-infection in comparison

  1. Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells

    International Nuclear Information System (INIS)

    Gao, Zhen; Xu, Michael S.; Barnett, Tamara L.; Xu, C. Wilson

    2011-01-01

    Research highlights: → Resveratrol induces cellular senescence in glioma cell. → Resveratrol inhibits mono-ubiquitination of histone H2B at K120. → Depletion of RNF20, phenocopies the inhibitory effects of resveratrol. → Mono-ubiquitination of histone H2B at K120 is a novel target of resveratrol. → RNF20 inhibits cellular senescence in proliferating glioma cells. -- Abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene), a polyphenol naturally occurring in grapes and other plants, has cancer chemo-preventive effects and therapeutic potential. Although resveratrol modulates multiple pathways in tumor cells, how resveratrol or its affected pathways converge on chromatin to mediate its effects is not known. Using glioma cells as a model, we showed here that resveratrol inhibited cell proliferation and induced cellular hypertrophy by transforming spindle-shaped cells to enlarged, irregular and flatten-shaped ones. We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-β-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells. Consistent with these observations, we demonstrated that resveratrol inhibited clonogenic efficiencies in vitro and tumor growth in a xenograft model. Furthermore, we found that acute treatment of resveratrol inhibited mono-ubiquitination of histone H2B at K120 (uH2B) in breast, prostate, pancreatic, lung, brain tumor cells as well as primary human cells. Chronic treatment with low doses of resveratrol also inhibited uH2B in the resveratrol-induced senescent glioma cells. Moreover, we showed that depletion of RNF20, a ubiquitin ligase of histone H2B, inhibited uH2B and induced cellular senescence in glioma cells in vitro, thereby recapitulated the effects of resveratrol. Taken together, our results suggest that uH2B is a novel direct or indirect chromatin target of resveratrol and RNF20 plays an important role in inhibiting cellular senescence programs that are

  2. Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Zhen; Xu, Michael S.; Barnett, Tamara L. [Nevada Cancer Institute, Las Vegas, NV 89135 (United States); Xu, C. Wilson, E-mail: wxu@nvcancer.org [Nevada Cancer Institute, Las Vegas, NV 89135 (United States)

    2011-04-08

    Research highlights: {yields} Resveratrol induces cellular senescence in glioma cell. {yields} Resveratrol inhibits mono-ubiquitination of histone H2B at K120. {yields} Depletion of RNF20, phenocopies the inhibitory effects of resveratrol. {yields} Mono-ubiquitination of histone H2B at K120 is a novel target of resveratrol. {yields} RNF20 inhibits cellular senescence in proliferating glioma cells. -- Abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene), a polyphenol naturally occurring in grapes and other plants, has cancer chemo-preventive effects and therapeutic potential. Although resveratrol modulates multiple pathways in tumor cells, how resveratrol or its affected pathways converge on chromatin to mediate its effects is not known. Using glioma cells as a model, we showed here that resveratrol inhibited cell proliferation and induced cellular hypertrophy by transforming spindle-shaped cells to enlarged, irregular and flatten-shaped ones. We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-{beta}-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells. Consistent with these observations, we demonstrated that resveratrol inhibited clonogenic efficiencies in vitro and tumor growth in a xenograft model. Furthermore, we found that acute treatment of resveratrol inhibited mono-ubiquitination of histone H2B at K120 (uH2B) in breast, prostate, pancreatic, lung, brain tumor cells as well as primary human cells. Chronic treatment with low doses of resveratrol also inhibited uH2B in the resveratrol-induced senescent glioma cells. Moreover, we showed that depletion of RNF20, a ubiquitin ligase of histone H2B, inhibited uH2B and induced cellular senescence in glioma cells in vitro, thereby recapitulated the effects of resveratrol. Taken together, our results suggest that uH2B is a novel direct or indirect chromatin target of resveratrol and RNF20 plays an important role in inhibiting cellular

  3. A Study on Mono-energetic Beam Source Using Characteristic X-ray for Substance Identification System

    International Nuclear Information System (INIS)

    Lee, Hwan Soo

    2009-02-01

    A new mono-energetic beam source was developed by using characteristic X-ray for improving performance of the substance identification system. Most of inspection systems use X-ray tubes for their source modules. However, the broad energy spectrum of X-ray tube causes an increase of uncertainty. In this study, it was found that mono-energetic beam sources can be generated by using X-ray tube and the designed target filter assembly. In order to investigate the monoenergetic beam source, the sensitivity study was conducted with a series of different X-ray tube potentials, radiator and filter materials using Monte Carlo simulation. The developed beam sources have a mono-energy peak at 69 keV, 78 keV and 99 keV, and they are named as characteristic X-ray beam BEAM69, BEAM78 and BEAM99, respectively. The characteristic X-ray beam intensity was over thirty three times more than that of hardening beam used previous work at Hanyang University. And BEAM69 and BEAM99 were applied to the substance identification system as a source. The relative error between results of characteristic X-ray beams and 69 keV and 99 keV photons was about 2% on the average for five unknown materials. In comparison with experiment results by using hardening beam, characteristic X-ray beam achieves better accuracy which is about 6.46 % on the average. Hence, it is expected that the developed characteristic X-ray beam source helps lower uncertainty of the inspection system, and the inspection time will be reduced considerably due to its high beam intensity

  4. Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments.

    Science.gov (United States)

    Regier, Mary C; Maccoux, Lindsey J; Weinberger, Emma M; Regehr, Keil J; Berry, Scott M; Beebe, David J; Alarid, Elaine T

    2016-08-01

    Heterotypic interactions in cancer microenvironments play important roles in disease initiation, progression, and spread. Co-culture is the predominant approach used in dissecting paracrine interactions between tumor and stromal cells, but functional results from simple co-cultures frequently fail to correlate to in vivo conditions. Though complex heterotypic in vitro models have improved functional relevance, there is little systematic knowledge of how multi-culture parameters influence this recapitulation. We therefore have employed a more iterative approach to investigate the influence of increasing model complexity; increased heterotypic complexity specifically. Here we describe how the compartmentalized and microscale elements of our multi-culture device allowed us to obtain gene expression data from one cell type at a time in a heterotypic culture where cells communicated through paracrine interactions. With our device we generated a large dataset comprised of cell type specific gene-expression patterns for cultures of increasing complexity (three cell types in mono-, co-, or tri-culture) not readily accessible in other systems. Principal component analysis indicated that gene expression was changed in co-culture but was often more strongly altered in tri-culture as compared to mono-culture. Our analysis revealed that cell type identity and the complexity around it (mono-, co-, or tri-culture) influence gene regulation. We also observed evidence of complementary regulation between cell types in the same heterotypic culture. Here we demonstrate the utility of our platform in providing insight into how tumor and stromal cells respond to microenvironments of varying complexities highlighting the expanding importance of heterotypic cultures that go beyond conventional co-culture.

  5. Industrial Application of Thin Films (TiAl)N Deposited on Thermo-Wells

    International Nuclear Information System (INIS)

    Velez, G.; Jaramillo, S.; Arango, Y. C.; Devia, D.; Quintero, J.; Devia, A.

    2006-01-01

    The thermo-well is formed by two layers, one layer is a ceramic and the other layer is anviloy (comprised tungsten). They are used to coat the thermocouple in the control temperature system during the Aluminum-Silicon alloy melting process. After two weeks of continuous work at 750 deg. C of temperature (the alloy temperature), a high wear in this material is observed, affecting the ceramic. (TiAl)N thin films are deposited directly on the anviloy substrates by the PAPVD (Plasma Assisted Physics Vapor Deposition) in arc pulsed technique, using a TiAl target in a mono-vaporizer system, composed by a reactor and a power controlled system. Two opposite electrodes are placed into the reactor and discharge is produced by a controlled power system. The XRD (X-ray diffraction) patterns show the presence of the (TiAl)N thin film peaks. The morphological characteristics are studied by the scanning probe microscopy (SPM)

  6. Versatile sputtering technology for Al2O3 gate insulators on graphene

    Directory of Open Access Journals (Sweden)

    Miriam Friedemann, Mirosław Woszczyna, André Müller, Stefan Wundrack, Thorsten Dziomba, Thomas Weimann and Franz J Ahlers

    2012-01-01

    Full Text Available We report a novel, sputtering-based fabrication method of Al2O3 gate insulators on graphene. Electrical performance of dual-gated mono- and bilayer exfoliated graphene devices is presented. Sputtered Al2O3 layers possess comparable quality to oxides obtained by atomic layer deposition with respect to a high relative dielectric constant of about 8, as well as low-hysteresis performance and high breakdown voltage. We observe a moderate carrier mobility of about 1000 cm2 V− 1 s−1 in monolayer graphene and 350 cm2 V− 1 s−1 in bilayer graphene, respectively. The mobility decrease can be attributed to the resonant scattering on atomic-scale defects, likely originating from the Al precursor layer evaporated prior to sputtering.

  7. Alles is al uitgevonden

    NARCIS (Netherlands)

    J.G.M. van Marrewijk (Charles)

    1996-01-01

    textabstractDe voordelen van vrijhandel zijn zeer beperkt, al-thans als we de empirische schattingen van vooraanstaande economen en internationale organisaties mogen geloven. Zo worden de voordelen van liberalisatie voor de Europese Unie geraamd op ongeveer 0,5% van het bnp 1. De door het IMF

  8. Lukman et al. (5)

    African Journals Online (AJOL)

    DELL

    1 Civil Engineering Department, Obafemi Awolowo University, Ile-Ife- Nigeria and Corresponding author. 2Department of Water Resources and Environmental Engineering, Ahmadu Bello University, Samaru, Zaria- Nigeria s Department of Civil Engineering, University of Hafr Al-Batin, Hafr Al-Batin, Saudi Arabia.

  9. Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines.

    Science.gov (United States)

    Sakamoto, Ryu; Sakurai, Shunya; Maruoka, Keiji

    2017-07-06

    The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the alkylsilyl peroxides, as well as to the primary amides and arylamines. Mechanistic studies suggest that the present reaction should proceed through a free-radical process that includes alkyl radicals generated from the alkylsilyl peroxides. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

    Energy Technology Data Exchange (ETDEWEB)

    King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T. [School of Chemistry, University of Nottingham (United Kingdom); Tuna, Floriana; McInnes, Eric J.L. [School of Chemistry and Photon Science Institute, University of Manchester (United Kingdom)

    2013-04-26

    Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). (Copyright copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  11. Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome as compared to germ-free mice

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper

    Every single species of the gut microbiota produce low-molecular-weight compounds that are absorbed constantly from the intestinal lumen and carried to systemic circulation where they play a direct role in health and disease. However, very few studies address the host metabolome as a function...... of colonizing bacteria. In this study the effect of the Lactobacillus acidophilus NCFM strain was investigated by comparing the metabolome of mono-colonized and germ-free mice in several compartments. By liquid-chromatography coupled to mass spectrometry, we were able to show that the metabolome differed...

  12. The family Rhabdoviridae: Mono- and bipartite negative-sense RNA viruses with diverse genome organization and common evolutionary origins

    Science.gov (United States)

    Dietzgen, Ralf G.; Kondo, Hideki; Goodin, Michael M.; Kurath, Gael; Vasilakis, Nikos

    2017-01-01

    The family Rhabdoviridae consists of mostly enveloped, bullet-shaped or bacilliform viruses with a negative-sense, single-stranded RNA genome that infect vertebrates, invertebrates or plants. This ecological diversity is reflected by the diversity and complexity of their genomes. Five canonical structural protein genes are conserved in all rhabdoviruses, but may be overprinted, overlapped or interspersed with several novel and diverse accessory genes. This review gives an overview of the characteristics and diversity of rhabdoviruses, their taxonomic classification, replication mechanism, properties of classical rhabdoviruses such as rabies virus and rhabdoviruses with complex genomes, rhabdoviruses infecting aquatic species, and plant rhabdoviruses with both mono- and bipartite genomes.

  13. Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis

    Energy Technology Data Exchange (ETDEWEB)

    Hirata, Fusao, E-mail: fhirata@wayne.edu; Harada, Takasuke; Corcoran, George B.; Hirata, Aiko

    2014-01-15

    Highlight: • Nuclear mono-ubiquitinated annexin A1 is involved in DNA damage induced mutagenesis. • Dietary flavonoids bind to and inhibit purified mono-ubiquitinated annexin A1 helicase. • Dietary flavonoids show anti-mutagenic action. • Annexin A1 may serve as a putative target of cancer chemoprevention by flavonoids. - Abstract: In order to investigate the mechanisms of anti-mutagenic action by dietary flavonoids, we investigated if they inhibit mutation of the thymidine kinase (tk) gene in L5178Ytk(±) lymphoma cells. Silibinin, quercetin and genistein suppressed mutation of the tk gene induced in L5178Ytk(±) lymphoma cells by methyl methanesulfonate (MMS) and As{sup 3+}. Flavone and flavonol were less effective. To establish that mutation of the tk gene in L5178Ytk(±) lymphoma cells by MMS and As{sup 3+} is mediated through mono-ubiquitinated annexin A1, L5178Ytk(±) lymphoma cells were treated with annexin A1 anti-sense oligonucleotide. The treatment reduced mRNA as well as protein levels of annexin A1, and suppressed mutation of the tk gene. Nuclear extracts from L5178Ytk(±) lymphoma cells catalyzed translesion DNA synthesis with an oligonucleotide template containing 8-oxo-guanosine in an annexin A1 dependent manner. This translesion DNA synthesis was inhibited by the anti-mutagenic flavonoids, silibinin, quercetin and genistein, in a concentration dependent manner, but only slightly by flavone and flavonol. Because these observations implicate involvement of annexin A1 in mutagenesis, we examined if flavonoids suppress nuclear annexin A1 helicase activity. Silibinin, quercetin and genistein inhibited ssDNA binding, DNA chain annealing and DNA unwinding activities of purified nuclear mono-ubiquitinated annexin A1. Flavone and flavonol were ineffective. The apparent direct binding of anti-mutagenic flavonoids to the annexin A1 molecule was supported by fluorescence quenching. Taken together, these findings illustrate that nuclear annexin A1 may be

  14. Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis

    International Nuclear Information System (INIS)

    Hirata, Fusao; Harada, Takasuke; Corcoran, George B.; Hirata, Aiko

    2014-01-01

    Highlight: • Nuclear mono-ubiquitinated annexin A1 is involved in DNA damage induced mutagenesis. • Dietary flavonoids bind to and inhibit purified mono-ubiquitinated annexin A1 helicase. • Dietary flavonoids show anti-mutagenic action. • Annexin A1 may serve as a putative target of cancer chemoprevention by flavonoids. - Abstract: In order to investigate the mechanisms of anti-mutagenic action by dietary flavonoids, we investigated if they inhibit mutation of the thymidine kinase (tk) gene in L5178Ytk(±) lymphoma cells. Silibinin, quercetin and genistein suppressed mutation of the tk gene induced in L5178Ytk(±) lymphoma cells by methyl methanesulfonate (MMS) and As 3+ . Flavone and flavonol were less effective. To establish that mutation of the tk gene in L5178Ytk(±) lymphoma cells by MMS and As 3+ is mediated through mono-ubiquitinated annexin A1, L5178Ytk(±) lymphoma cells were treated with annexin A1 anti-sense oligonucleotide. The treatment reduced mRNA as well as protein levels of annexin A1, and suppressed mutation of the tk gene. Nuclear extracts from L5178Ytk(±) lymphoma cells catalyzed translesion DNA synthesis with an oligonucleotide template containing 8-oxo-guanosine in an annexin A1 dependent manner. This translesion DNA synthesis was inhibited by the anti-mutagenic flavonoids, silibinin, quercetin and genistein, in a concentration dependent manner, but only slightly by flavone and flavonol. Because these observations implicate involvement of annexin A1 in mutagenesis, we examined if flavonoids suppress nuclear annexin A1 helicase activity. Silibinin, quercetin and genistein inhibited ssDNA binding, DNA chain annealing and DNA unwinding activities of purified nuclear mono-ubiquitinated annexin A1. Flavone and flavonol were ineffective. The apparent direct binding of anti-mutagenic flavonoids to the annexin A1 molecule was supported by fluorescence quenching. Taken together, these findings illustrate that nuclear annexin A1 may be a novel

  15. Synthesis of substituted mono- and diindole C-nucleoside analogues from sugar terminal alkynes by sequential sonogashira/heteroannulation reaction.

    Science.gov (United States)

    Zhang, Fuyi; Mu, Delong; Wang, Liming; Du, Pengfei; Han, Fen; Zhao, Yufen

    2014-10-17

    The synthesis of substituted mono- and diindole C-nucleoside analogues has been achieved in good to excellent yields by sequential Sonogashira coupling/NaAuCl4-catalyzed heteroannulation reactions of substituted 2-iodoanilines with various sugar terminal alkynes in one pot. The method is general, mild, and efficient and suitable for a wide range of sugar substrates, and 42 examples are given. The amino group of the substituted 2-iodoanilines is unprotected. The sugar terminal alkynes include furanosides, pyranosides, and acyclic glycosides with free hydroxyl groups, sensitive functional subtituents, and various protecting groups having different steric hindrance.

  16. A systematic study of the isothermal crystallization of the mono-alcohol n-butanol monitored by dielectric spectroscopy

    DEFF Research Database (Denmark)

    Jensen, Mikkel Hartmann; Hecksher, Tina; Niss, Kristine

    2015-01-01

    Isothermal crystallization of the mono-hydroxyl alcohol n-butanol was studied with dielectric spectroscopy in real time. The crystallization was carried out using two different sample cells at 15 temperatures between 120 K and 134 K. Crystallization is characterized by a decrease of the dielectric...... intensity. In addition, a shift in relaxation times to shorter times was observed during the crystallization process for all studied temperatures. The two different sample environments induced quite different crystallization behaviors, consistent and reproducible over all studied temperatures...... that a microscopic interpretation of crystallization measurements requires multiple probes, sample cells, and protocols....

  17. VELOCIRAPTOR: An X-band photoinjector and linear accelerator for the production of Mono-Energetic {gamma}-rays

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.G., E-mail: anderson131@llnl.gov [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94551 (United States); Albert, F.; Bayramian, A.J.; Beer, G.; Bonanno, R.E.; Cross, R.R.; Deis, G.; Ebbers, C.A.; Gibson, D.J.; Hartemann, F.V.; Houck, T.L.; Marsh, R.A.; McNabb, D.P.; Messerly, M.J.; Scarpetti, R.D.; Shverdin, M.Y.; Siders, C.W.; Wu, S.S.; Barty, C.P.J. [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94551 (United States); Adolphsen, C.E. [SLAC National Accelerator Laboratory, 2575 Sand Hill Rd., Menlo Park, CA 94025 (United States); and others

    2011-11-21

    The rf photoinjector and linear accelerator in the Mono-Energetic Gamma-ray (MEGa-ray) facility at LLNL is presented. This machine uses 11.4 GHz rf technology to accelerate a high-brightness electron beam up to 250 MeV to produce MeV {gamma}-rays through Compton scattering with a Joule-class laser pulse. Compton scattering-based generation of high flux, narrow bandwidth {gamma}-rays places stringent requirements on the performance of the accelerator. The component parts of the accelerator are presented and their requirements described. Simulations of expected electron beam parameters and the resulting light source properties are presented.

  18. Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

    International Nuclear Information System (INIS)

    King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T.; Tuna, Floriana; McInnes, Eric J.L.

    2013-01-01

    Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). (Copyright copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  19. Obtention of Samarium and Gadolinium concentrates by solvent extraction using mono-2-ethylhexyl ester of 2-ethylhexyl phosphonic acid

    International Nuclear Information System (INIS)

    Miranda Junior, Pedro

    1996-01-01

    The rare earth chlorides solution employed in this study, which is constituted by medium and heavy fractions, is derived from monazite processing accomplished by NUCLEMON-Mineroquimica (SP). This solution shows an acidity about 1.18 M and 189 g/L of rare earth oxides, containing as main constituents: Sm(34.55%), Gd(23.85%), Dy (6.82%), and Y (24.45%). It was used, as organic phase, 2-ethylhexyl phosphonic acid, mono-2-ethylhexylester diluted to 1 M in isododecane. (author)

  20. Dynamic Covalent Self-Assembly of Mono-, Bi- and Trimacro-cycles from Hydrogen Bonded Preorganized Templates

    Institute of Scientific and Technical Information of China (English)

    LIN Jianbin; WU Jing; JIANG Xikui; LI Zhanting

    2009-01-01

    This paper describes the dynamic covalent assembly of three mono-, bi- and trimacrocycles by utilizing hydro-gen bonding-driven zigzag anthranilamides as "leading" components. The monomacrocycle, a tetraamino molecule, was prepared from the [24+2] coupling reaction of a "'U"-shaped dialdehyde and a porphyrin diamine, followed by the reduction of the macrocyclic tetraimine by NaBH3CN, while the bi-and trimacrocycles were obtained through two six-component coupling reactions with rigid tri- and tetraamino-appended oligomers as templates.

  1. STABILITY OF EMULSIFIER-FREE EMULSION COPOLYMERIZATION OF METHYL METHACRYLATE/ BUTYL ACRYLATE/SODIUM MONO(ETHYL POLYOXYETHYLENE) MALEATE

    Institute of Scientific and Technical Information of China (English)

    Mao-gen Zhang; Zhi-xue Weng; Zhi-ming Huang; Zu-ren Pan

    1999-01-01

    A series of new water-soluble bifunctional comonomers having both carboxyl and alkyl polyoxyethylene groups, such as sodium mono(ethyl polyoxyethylene) maleate (ZE series) with various molecular weights of polyoxyethylene ethyl ether, were synthesized and characterized. The effects of the structural factor, the amount and feeding mode of the comonomers, the initiator concentration and polymerization temperature on the stability of emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and butyl acrylate (BA) in the presence of a small amount of ZE with potassium persulfate as initiator were investigated. Stable, almost monodispersed MMA/BA/ZE emulsifier-free latex particles were prepared.

  2. Search for Dark Matter in the mono-X final states (X = jets, Z, W, H) with ATLAS

    CERN Document Server

    Lo Sterzo, Francesco; The ATLAS collaboration

    2018-01-01

    Dark Matter searches in the ATLAS Experiment are perfomed analysing a wide number of experimental signatures. Among these, mono-X searches are a powerful tool since many models can be probed depending on the nature (jet, photon, vector boson, Higgs boson) of the Standard Model object which is used to identify and select the events. In this report a short introduction of the theoretical framweork is given, followed by three examples of different signatures that probe different theoretical models that describe an interaction between the Standard Model and Dark Matter.

  3. Synthesis, fluorescence properties of Tb(Ⅲ) complexes with novel mono-substituted β-diketone ligands

    Institute of Scientific and Technical Information of China (English)

    罗一鸣; 李石凤; 李军; 陈学娟; 唐瑞仁

    2010-01-01

    Two novel pyridine-2,6-dicarboxylic acid derivatives of mono-β-diketone named methyl 6-biphenylacetyl-2-pyridinecarboxylate (MBP) and 6-biphenylacetyl-2-pyridinecarboxylic acid (BAA) and their corresponding binary complexes Tb(MBP)3.6H2O and Tb(BAA)3·6H2O were synthesized. The ligands were characterized by elemental analysis, FT-IR and 1H-NMR, and the complexes were characterized with elemental analysis, FT-IR, 1H-NMR and thermogravimetric and differential thermal analysis(TG-DTA). The investigation of fluo...

  4. A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

    OpenAIRE

    Cankar, K.; Houwelingen, van, A.M.M.L.; Bosch, H.J.; Sonke, Th.; Bouwmeester, H.J.; Beekwilder, M.J.

    2011-01-01

    Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene synthase in yeast, led to formation of trans-nootkatol, cis-nootkatol and (+)-nootkatone. The novel enzyme was also found to catalyse a three step conversion of germacrene A to germacra-1(10),4,11(13)-tr...

  5. Pd(II)-Catalyzed Hydroxyl-Directed C–H Olefination Enabled by Mono-Protected Amino Acid Ligands

    Science.gov (United States)

    Lu, Yi; Wang, Dong-Hui; Engle, Keary M.

    2010-01-01

    A novel Pd(II)-catalyzed ortho-C–H olefination protocol has been developed using spatially remote, unprotected tertiary, secondary, and primary alcohols as the directing groups. Mono-N-protected amino acid ligands were found to promote the reaction, and an array of olefin coupling partners could be used. When electron-deficient alkenes were used, the resulting olefinated intermediates underwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyran products, which could be converted into ortho-alkylated alcohols under hydrogenolysis conditions. The mechanistic details of the oxidative cyclization step are discussed and situated in the context of the overall catalytic cycle. PMID:20359184

  6. Interview als Text vs. Interview als Interaktion

    Directory of Open Access Journals (Sweden)

    Arnulf Deppermann

    2013-09-01

    Full Text Available Das Interview ist nach wie vor das beliebteste sozialwissenschaftliche Verfahren des Datengewinns. Ökonomie der Erhebung, Vergleichbarkeit und die Möglichkeit, Einsicht in Praxisbereiche und historisch-biografische Dimensionen zu erhalten, die der direkten Beobachtung kaum zugänglich sind, machen seine Attraktivität aus. Zugleich mehren sich Kritiken, die seine Leistungsfähigkeit problematisieren, indem sie auf die begrenzte Reichweite der Explikationsfähigkeiten der Befragten, die Reaktivität der Erhebung oder die Differenz zwischen Handeln und dem Bericht über Handeln verweisen. Im Beitrag wird zwischen Ansätzen, die das Interview als Text, und solchen, die es als Interaktion verstehen, unterschieden. Nach dem Text-Verständnis werden Interviews unter inhaltlichen Gesichtspunkten analysiert und als Zugang zu einer vorgängigen sozialen oder psychischen Wirklichkeit angesehen. Das Interaktions-Verständnis versteht Interviews dagegen als situierte Praxis, in welcher im Hier und Jetzt von InterviewerInnen und Befragten gemeinsam soziale Sinnstrukturen hergestellt werden. Anhand ubiquitärer Phänomene der Interviewinteraktion – Fragen, Antworten und die Selbstpositionierung von InterviewerInnen und Befragten – werden Praktiken des interaktiv-performativen Handelns im Interview dargestellt. Ihre Relevanz für die Interviewkonstitution und ihre Erkenntnispotenziale für die Interviewauswertung werden aufgezeigt. Es wird dafür plädiert, die interaktive Konstitutionsweise von Interviews empirisch zu erforschen und methodisch konsequent zu berücksichtigen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1303131

  7. Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.

    Science.gov (United States)

    Taha, Hesham; Dove, Stefan; Geduhn, Jens; König, Burkhard; Shen, Yuequan; Tang, Wei-Jen; Seifert, Roland

    2012-01-01

    Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor (EF), a highly active calmodulin-dependent adenylyl cyclase (AC). Conventional antibiotic treatment is ineffective against either toxaemia or antibiotic-resistant strains. Thus, more effective drugs for anthrax treatment are needed. Our previous studies showed that EF is differentially inhibited by various purine and pyrimidine nucleotides modified with N-methylanthraniloyl (MANT)- or anthraniloyl (ANT) groups at the 2'(3')-O-ribosyl position, with the unique preference for the base cytosine (Taha et al., Mol Pharmacol 75:693 (2009)). MANT-CTP was the most potent EF inhibitor (K (i), 100 nM) among 16 compounds studied. Here, we examined the interaction of EF with a series of 18 2',3'-O-mono- and bis-(M)ANT-substituted nucleotides, recently shown to be very potent inhibitors of the AC toxin from Bordetella pertussis, CyaA (Geduhn et al., J Pharmacol Exp Ther 336:104 (2011)). We analysed purified EF and EF mutants in radiometric AC assays and in fluorescence spectroscopy studies and conducted molecular modelling studies. Bis-MANT nucleotides inhibited EF competitively. Propyl-ANT-ATP was the most potent EF inhibitor (K (i), 80 nM). In contrast to the observations made for CyaA, introduction of a second (M)ANT-group decreased rather than increased inhibitor potency at EF. Activation of EF by calmodulin resulted in effective fluorescence resonance energy transfer (FRET) from tryptophan and tyrosine residues located in the vicinity of the catalytic site to bis-MANT-ATP, but FRET to bis-MANT-CTP was only small. Mutations N583Q, K353A and K353R differentially altered the inhibitory potencies of bis-MANT-ATP and bis-MANT-CTP. The nucleotide binding site of EF accommodates bulky bis-(M)ANT-substituted purine and pyrimidine nucleotides, but the fit is suboptimal compared to CyaA. These data provide a basis

  8. The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

    Directory of Open Access Journals (Sweden)

    Paolo Swuec

    2017-01-01

    Full Text Available Activation of the main DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex. FANCI and FANCD2 form a stable complex; however, the molecular basis of their ubiquitination is ill defined. FANCD2 mono-ubiquitination by FANCL is stimulated by the presence of the FANCB and FAAP100 core complex components, through an unknown mechanism. How FANCI mono-ubiquitination is achieved remains unclear. Here, we use structural electron microscopy, combined with crosslink-coupled mass spectrometry, to find that FANCB, FANCL, and FAAP100 form a dimer of trimers, containing two FANCL molecules that are ideally poised to target both FANCI and FANCD2 for mono-ubiquitination. The FANCC-FANCE-FANCF subunits bridge between FANCB-FANCL-FAAP100 and the FANCI-FANCD2 substrate. A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. Our data provide a model to explain how equivalent mono-ubiquitination of FANCI and FANCD2 occurs.

  9. In vitro quantification of the performance of model-based mono-planar and bi-planar fluoroscopy for 3D joint kinematics estimation.

    Science.gov (United States)

    Tersi, Luca; Barré, Arnaud; Fantozzi, Silvia; Stagni, Rita

    2013-03-01

    Model-based mono-planar and bi-planar 3D fluoroscopy methods can quantify intact joints kinematics with performance/cost trade-off. The aim of this study was to compare the performances of mono- and bi-planar setups to a marker-based gold-standard, during dynamic phantom knee acquisitions. Absolute pose errors for in-plane parameters were lower than 0.6 mm or 0.6° for both mono- and bi-planar setups. Mono-planar setups resulted critical in quantifying the out-of-plane translation (error bi-planar in quantifying the rotation along bone longitudinal axis (error bi-planar (error comparable to bi-planar, but with halved computational costs, halved segmentation time and halved ionizing radiation dose. Bi-planar analysis better compensated for the out-of-plane uncertainty that is differently propagated to relative kinematics depending on the setup. To take its full benefits, the motion task to be investigated should be designed to maintain the joint inside the visible volume introducing constraints with respect to mono-planar analysis.

  10. Universitat popular al Cabanyal

    OpenAIRE

    Ribés Granell, Juan Miguel

    2012-01-01

    La intención es dotar al barrio de un gran espacio verde y de un edificio de interés para los vecinos que enriquezca al Cabanyal, ya que actualmente se encuentra en proceso de degradación. Se pretende desarrollar un proyecto que signifique una mejora en la predisposición del visitante, cubriendo sus necesidades. Al mismo tiempo, se busca crear un espacio arquitectónico que mejore la relación entre las actividades que incluye y su entorno. El proyecto está condicionado por cuatro aspectos fund...

  11. Some transition metal complexes derived from mono- and di-ethynyl perfluorobenzenes.

    Science.gov (United States)

    Armitt, David J; Bruce, Michael I; Gaudio, Maryka; Zaitseva, Natasha N; Skelton, Brian W; White, Allan H; Le Guennic, Boris; Halet, Jean-François; Fox, Mark A; Roberts, Rachel L; Hartl, Frantisek; Low, Paul J

    2008-12-21

    Transition metal alkynyl complexes containing perfluoroaryl groups have been prepared directly from trimethylsilyl-protected mono- and di-ethynyl perfluoroarenes by simple desilylation/metallation reaction sequences. Reactions between Me(3)SiC[triple bond, length as m-dash]CC(6)F(5) and RuCl(dppe)Cp' [Cp' = Cp, Cp*] in the presence of KF in MeOH give the monoruthenium complexes Ru(C[triple bond, length as m-dash]CC(6)F(5))(dppe)Cp' [Cp' = Cp (); Cp* ()], which are related to the known compound Ru(C[triple bond, length as m-dash]CC(6)F(5))(PPh(3))(2)Cp (). Treatment of Me(3)SiC[triple bond, length as m-dash]CC(6)F(5) with Pt(2)(mu-dppm)(2)Cl(2) in the presence of NaOMe in MeOH gave the bis(alkynyl) complex Pt(2)(mu-dppm)(2)(C[triple bond, length as m-dash]CC(6)F(5))(2) (). The Pd(0)/Cu(i)-catalysed reactions between Au(C[triple bond, length as m-dash]CC(6)F(5))(PPh(3)) and Mo( identical withCBr)(CO)(2)Tp* [Tp* = hydridotris(3.5-dimethylpyrazoyl)borate], Co(3)(mu(3)-CBr)(mu-dppm)(CO)(7) or IC[triple bond, length as m-dash]CFc [Fc = (eta(5)-C(5)H(4))FeCp] afford Mo( identical withCC[triple bond, length as m-dash]CC(6)F(5))(CO)(2)Tp* (), Co(3)(mu(3)-CC[triple bond, length as m-dash]CC(6)F(5))(mu-dppm)(CO)(7) () and FcC[triple bond, length as m-dash]CC[triple bond, length as m-dash]CC(6)F(5) (), respectively. The diruthenium complexes 1,4-{Cp'(PP)RuC[triple bond, length as m-dash]C}(2)C(6)F(4) [(PP)Cp' = (PPh(3))(2)Cp (); (dppe)Cp (); (dppe)Cp* ()] are prepared from 1,4-(Me(3)SiC[triple bond, length as m-dash]C)(2)C(6)F(4) in a manner similar to that described for the monoruthenium complexes -. The non-fluorinated complexes 1,4-{Cp'(PP)RuC[triple bond, length as m-dash]C}(2)C(6)H(4) [(PP)Cp' = (PPh(3))(2)Cp (); (dppe)Cp (); (dppe)Cp* ()], prepared for comparison, are obtained from 1,4-(Me(3)SiC[triple bond, length as m-dash]C)(2)C(6)H(4). Spectro-electrochemical studies of the ruthenium aryl and arylene alkynyl complexes - and -, together with DFT-based computational

  12. ESTRUCTURA PRIMARIA DE LA CADENA Z EN EL MONO DEL NUEVO MUNDO AOTUS NANCYMAAE

    Directory of Open Access Journals (Sweden)

    HERNANDO DEL CASTILLO

    2008-12-01

    Full Text Available La cadena z es una proteína transmembranal que se encuentra en los linfocitos T, uno de los tipos de células más importantes en el sistema inmune adaptativo, haciendo parte de un complejo multimérico que se ubica en la superficie de la célula y que se encarga, por un lado, del reconocimiento antigénico y por otro, de la transmisión de señales durante la activación de la misma. Esta proteína es una de las que primero se fosforila luego de la estimulación a través del receptor y se sabe que es esencial en los primeros eventos de señalización. Dobles mutantes de esta molécula muestran una respuesta adaptativa inadecuada; así mismo, se ha visto que su expresión está alterada en cáncer y en algunas enfermedades auto-inmunes. La fosforilación en residuos de tirosina que se encuentran en los motivos de activación de residuos de tirosina de los receptores inmunes (ITAMs, de los cuales hay tres en la región citoplasmática, ha demostrado ser uno de los eventos principales durante la activación. En este reporte se presenta la caracterización de la estructura primaria de la cadena z en los monos del nuevo mundo Aotus nancymaae; la secuencia de aminoácidos se dedujo a partir de la secuencia nucleotídica de su cADN. Las moléculas de Aotus presentaron una identidad del 95.5 y del 95.7% con la molécula de humano en las secuencias de nucleótidos y de aminoácidos, respectivamente. Una comparación de la proteína por regiones, mostró una identidad del 100% en la región extracelular y la conservación de residuos y regiones importantes en el resto de la molécula; esto incluye aminoácidos polares en la región transmembranal y los ITAMs en la región citoplasmática. Los resultados sugieren que la proteína de Aotus es plenamente funcional y que los procesos de activación de los linfocitos T se suceden de manera similar a lo descrito en humanos. El resultado mostrado aquí soporta las evidencias previas en el sentido de que las

  13. Effect of Mono and Di-rhamnolipids on Biofilms Pre-formed by Bacillus subtilis BBK006.

    Science.gov (United States)

    De Rienzo, Mayri A Díaz; Martin, Peter J

    2016-08-01

    Different microbial inhibition strategies based on the planktonic bacterial physiology have been known to have limited efficacy on the growth of biofilms communities. This problem can be exacerbated by the emergence of increasingly resistant clinical strains. Biosurfactants have merited renewed interest in both clinical and hygienic sectors due to their potential to disperse microbial biofilms. In this work, we explore the aspects of Bacillus subtilis BBK006 biofilms and examine the contribution of biologically derived surface-active agents (rhamnolipids) to the disruption or inhibition of microbial biofilms produced by Bacillus subtilis BBK006. The ability of mono-rhamnolipids (Rha-C10-C10) produced by Pseudomonas aeruginosa ATCC 9027 and the di-rhamnolipids (Rha-Rha-C14-C14) produced by Burkholderia thailandensis E264, and phosphate-buffered saline to disrupt biofilm of Bacillus subtilis BBK006 was evaluated. The biofilm produced by Bacillus subtilis BBK006 was more sensitive to the di-rhamnolipids (0.4 g/L) produced by Burkholderia thailandensis than the mono-rhamnolipids (0.4 g/L) produced by Pseudomonas aeruginosa ATCC 9027. Rhamnolipids are biologically produced compounds safe for human use. This makes them ideal candidates for use in new generations of bacterial dispersal agents and useful for use as adjuvants for existing microbial suppression or eradication strategies.

  14. Effect of Xanthan, Mono-di-Glyceride and Cultivar on Physical and Sensory Properties of Canned Rice During Storage

    Directory of Open Access Journals (Sweden)

    A. Nasirpour

    2014-08-01

    Full Text Available Ready-to-eat or canned products have an important place in urban life style. Rice is consumed by half of world population. Problems related to production of canned rice are the coherences of rice kernel, retrogradation of rice starch and physico-chemical changes of rice during storage. Main factors affecting physico-chemical properties of canned rice are rice cultivar, amylose and amylopectin content of kernels, precooking conditions, kernel composition and added stabilizers. In this study, effect of three cultivars, Basmati and two local cultivars, Tarom Mazandaran and Tarom Hashemi, also two types of stabilizers, Xanthan, Mono-di-glyceride, on sensory and physical properties of canned rice were studied. Type and level of stabilizers, cultivars and time had significant effect on texture of cooked rice. Initially during storage, Basmati had the highest firmness and Tarom Mazandaran and Tarom Hashemi had lower firmness. The results of texture analysis indicated that both stabilizers reduced firmness of cooked rice during storage. Adding xhanthan as stabilizer had higher effect on reducing of cooked rice firmness comparing to mono-di-glyceride. Result of color analysis showed that Basmati cultivar was most yellowish and Tarom Mazandaran indicated maximum lightness. Sensory analysis of samples indicated that Basmati had the best score on texture, appearance and acceptability and Tarom Hashemi had the best score on taste and flavor. Type of stabilizer had significant effect on taste and flavor of cooked rice.

  15. Substituting poly- and mono-unsaturated fat for dietary carbohydrate reduces hyperinsulinemia in women with polycystic ovary syndrome.

    Science.gov (United States)

    Perelman, Dalia; Coghlan, Nicole; Lamendola, Cindy; Carter, Susan; Abbasi, Fahim; McLaughlin, Tracey

    2017-04-01

    Hyperinsulinemia is a prevalent feature of polycystic ovary syndrome (PCOS), contributing to metabolic and reproductive manifestations of the syndrome. Weight loss reduces hyperinsulinemia but weight regain is the norm, thus preventing long-term benefits. In the absence of weight loss, replacement of dietary carbohydrate (CHO) with mono/polyunsaturated fat reduces ambient insulin concentrations in non-PCOS subjects. The current study evaluated whether this dietary intervention could ameliorate hyperinsulinemia in women with PCOS. Obese women with PCOS (BMI 39 ± 7 kg/m 2 ) and insulin resistance completed a crossover study (Stanford University Clinical Research Center) comparing two isocaloric diets, prepared by research dietitians, containing 60% CHO/25% fat versus 40% CHO/45% fat (both 15% protein and ≤7% saturated fat). After 3 weeks on each diet, daylong glucose, insulin, and fasting lipid/lipoproteins were measured. Daylong glucose did not differ according to diet. Daylong insulin concentrations were substantially (30%) and significantly lower on the low CHO/higher fat diet. Beneficial changes in lipid profile were also observed. Replacement of dietary CHO with mono/polyunsaturated fat yields clinically important reductions in daylong insulin concentrations, without adversely affecting lipid profile in obese, insulin-resistant women with PCOS. This simple and safe dietary intervention may constitute an important treatment for PCOS. ClinicalTrials.gov Identifier: NCT00186459.

  16. Comparison of dimensionality reduction techniques for the fault diagnosis of mono block centrifugal pump using vibration signals

    Directory of Open Access Journals (Sweden)

    N.R. Sakthivel

    2014-03-01

    Full Text Available Bearing fault, Impeller fault, seal fault and cavitation are the main causes of breakdown in a mono block centrifugal pump and hence, the detection and diagnosis of these mechanical faults in a mono block centrifugal pump is very crucial for its reliable operation. Based on a continuous acquisition of signals with a data acquisition system, it is possible to classify the faults. This is achieved by the extraction of features from the measured data and employing data mining approaches to explore the structural information hidden in the signals acquired. In the present study, statistical features derived from the vibration data are used as the features. In order to increase the robustness of the classifier and to reduce the data processing load, dimensionality reduction is necessary. In this paper dimensionality reduction is performed using traditional dimensionality reduction techniques and nonlinear dimensionality reduction techniques. The effectiveness of each dimensionality reduction technique is also verified using visual analysis. The reduced feature set is then classified using a decision tree. The results obtained are compared with those generated by classifiers such as Naïve Bayes, Bayes Net and kNN. The effort is to bring out the better dimensionality reduction technique–classifier combination.

  17. Electrical and spectroscopic analysis of mono- and multi-tip pulsed corona discharges in air at atmospheric pressure

    Science.gov (United States)

    Mraihi, A.; Merbahi, N.; Yousfi, M.; Abahazem, A.; Eichwald, O.

    2011-12-01

    This work is devoted to the analysis of experimental results obtained in dry air at atmospheric pressure in a positive point-to-plane corona discharge under a pulsed applied voltage in the cases of anodic mono- and multi-tips. In the mono-tip case, the peak corona current is analysed as a function of several experimental parameters such as magnitude, frequency and duration of pulsed voltage and gap distance. The variation of the corona discharge current is correlated with the ozone production. Then in the multi-tip case, the electrical behaviour is analysed as a function of the distance between two contiguous tips and the tip number in order to highlight the region of creation active species for the lowest dissipated power. Intensified charge-coupled device pictures and electric field calculations as a function of inter-tip distance are performed to analyse the mutual effect between two contiguous tips. The optical emission spectra are measured in the UV-visible-NIR wavelength range between 200 nm and 800 nm, in order to identify the main excited species formed in an air corona discharge such as the usual first and second positive systems with first negative systems of molecular nitrogen. The identification of atomic species (O triplet and N) and the quenching of NOγ emission bands are also emphasized.

  18. Computational fluid dynamics study on mixing mode and power consumption in anaerobic mono- and co-digestion.

    Science.gov (United States)

    Zhang, Yuan; Yu, Guangren; Yu, Liang; Siddhu, Muhammad Abdul Hanan; Gao, Mengjiao; Abdeltawab, Ahmed A; Al-Deyab, Salem S; Chen, Xiaochun

    2016-03-01

    Computational fluid dynamics (CFD) was applied to investigate mixing mode and power consumption in anaerobic mono- and co-digestion. Cattle manure (CM) and corn stover (CS) were used as feedstock and stirred tank reactor (STR) was used as digester. Power numbers obtained by the CFD simulation were compared with those from the experimental correlation. Results showed that the standard k-ε model was more appropriate than other turbulence models. A new index, net power production instead of gas production, was proposed to optimize feedstock ratio for anaerobic co-digestion. Results showed that flow field and power consumption were significantly changed in co-digestion of CM and CS compared with those in mono-digestion of either CM or CS. For different mixing modes, the optimum feedstock ratio for co-digestion changed with net power production. The best option of CM/CS ratio for continuous mixing, intermittent mixing I, and intermittent mixing II were 1:1, 1:1 and 1:3, respectively. Copyright © 2016. Published by Elsevier Ltd.

  19. Characterization of the crystal orientation in mono-oriented films of HDPE/LLDPE blends by IR dichroism

    Energy Technology Data Exchange (ETDEWEB)

    Canevarolo, Sebastião V., E-mail: caneva@ufscar.br; Ravazzi, Camila; Silva, Jorge, E-mail: jorge.silva@ufscar.br [Departamento de Engenharia de Materiais, Universidade Federal de São Carlos Rod. Washington Luiz Km 235, 13565-905, SãoCarlos, SP - Brazil (Brazil); Elias, Marcelo [Motechfilm Produtos Plásticos, Estrada Municipal do Bonfim, 100, Pinhal, Cabreúva, SP - Brazil (Brazil)

    2016-03-09

    Polyethylene films are a common packaging material. The level and type of chain orientation in these films are a very important property which is of great care and concern of the converter personnel during the conformation process. Usually bi-orientation is the conventional procedure but when easy tear in one direction is needed mono-orientation is sought. This paper deal with the characterization of the crystalline orientation in films of polyethylene blends (HDPE/LLDPE) which have being oriented in two steps: initially the polymer was bi-oriented via extrusion-blown, cooled, and then in a second process hot stretched along the machine direction in order to produce mono-oriented films. In order to evaluate the orientation of the film, the polarization of the FT-IR beam was rotated 360° in steps of 5° by rotating the polarizer. In each step the absorbance spectrum was recorded and the corresponding dichroic ratio (DR) calculated after subtracting the baseline. With differential scanning calorimetry (DSC) was possible to infer about the changes in the morphology caused by the stretching.

  20. Electrical and spectroscopic analysis of mono- and multi-tip pulsed corona discharges in air at atmospheric pressure

    International Nuclear Information System (INIS)

    Mraihi, A; Merbahi, N; Yousfi, M; Abahazem, A; Eichwald, O

    2011-01-01

    This work is devoted to the analysis of experimental results obtained in dry air at atmospheric pressure in a positive point-to-plane corona discharge under a pulsed applied voltage in the cases of anodic mono- and multi-tips. In the mono-tip case, the peak corona current is analysed as a function of several experimental parameters such as magnitude, frequency and duration of pulsed voltage and gap distance. The variation of the corona discharge current is correlated with the ozone production. Then in the multi-tip case, the electrical behaviour is analysed as a function of the distance between two contiguous tips and the tip number in order to highlight the region of creation active species for the lowest dissipated power. Intensified charge-coupled device pictures and electric field calculations as a function of inter-tip distance are performed to analyse the mutual effect between two contiguous tips. The optical emission spectra are measured in the UV–visible–NIR wavelength range between 200 nm and 800 nm, in order to identify the main excited species formed in an air corona discharge such as the usual first and second positive systems with first negative systems of molecular nitrogen. The identification of atomic species (O triplet and N) and the quenching of NOγ emission bands are also emphasized.