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Sample records for al mono obeso

  1. Assistência ao paciente obeso mórbido submetido à cirurgia bariátrica: dificuldades do enfermeiro Asistencia al paciente obeso mórbido sometido a la cirugía bariátrica: dificultades del enfermero Perioperative care for morbid obese patient undergoing bariatric surgery: challenges for nurses

    Directory of Open Access Journals (Sweden)

    Denise Spósito Tanaka

    2009-10-01

    Full Text Available OBJETIVO: Identificar as dificuldades de enfermeiros de centro cirúrgico ao assistir pacientes obesos mórbidos submetidos à cirurgia bariátrica no período transoperatório. MÉTODOS: A amostra constou de 70 enfermeiros com experiência em assistência ao paciente obeso mórbido. Os dados foram coletados durante o 7º Congresso Brasileiro de Enfermeiros de Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização por meio de um questionário. RESULTADOS: A análise dos resultados apontou como dificuldades aquelas relacionadas ao espaço físico, materiais e equipamentos e à assistência de enfermagem específica ao paciente obeso mórbido. CONCLUSÃO: O conhecimento específico, a especialização e a experiência em Centro Cirúrgico darão o conforto, a segurança física e emocional necessárias a estes pacientes.OBJETIVO: Identificar las dificultades de enfermeros de centro quirúrgico en el cuidado a pacientes obesos mórbidos sometidos a cirugía bariátrica en el período transoperatorio. MÉTODOS: La muestra constó de 70 enfermeros con experiencia en asistencia al paciente obeso mórbido. Los datos fueron recolectados por medio de un cuestionario durante el 7º Congreso Brasileño de Enfermeros de Centro Quirúrgico, Recuperación Anestésica y Centro de Material y Esterilización. RESULTADOS: El análisis de los resultados identificó como dificultades aquellas relacionadas al espacio físico, materiales y equipos y a la asistencia de enfermería específica al paciente obeso mórbido. CONCLUSIÓN: El conocimiento específico, la especialización y la experiencia en Centro Quirúrgico darán el confort, la seguridad física y emocional que necesitan estos pacientes.OBJECTIVE: To identify the challenges for nurses during the perioperative for patients undergoing bariatric surgery. METHODS: The sample consisted of 70 nurses who had experience in providing care for morbid obese patients. Data were collected

  2. Peroxidación de lípidos y la respuesta del sistema de defensa antioxidante en el diabético tipo 2 obeso en comparación al diabético tipo 2 sin obesidad

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    Ramón Gaxiola-Robles

    2013-12-01

    Full Text Available Introducción: La diabetes se asocia a un incremento en la peroxidación de lípidos, cuantificada a partir del nivel de sustancias reactivas al ácido tiobarbitúrico (TBARS. En paralelo, se activa el sistema de defensa antioxidante (SDA para delimitar el daño. Objetivo: Determinar el grado de peroxidación de lípidos en individuos obesos diabéticos tipo 2 (DM2 y la respuesta del SDA en comparación con individuos con DM2 sin obesidad. Método: Se evaluó el daño a lípidos a través de la medición de las TBARS en dos grupos de 30 individuos. Se evaluó la respuesta del SDA por medio de la medición de la actividad de las enzimas catalasa (CAT, superóxido dismutasa (SOD y glutatión peroxidasa (GPx. Resultados: El grupo de DM2 obesos presentó un índice de masa corporal (IMC promedio de 38,6 ± 3,5 kg m² en comparación con el grupo control 24,7 ± 3,6 kg m² (p < 0,01. Los niveles de TBARS en el grupo en estudio fueron más altos en comparación al grupo control (p < 0.01. En un análisis de regresión lineal múltiple la actividad de SOD y CAT explicó los niveles de TBARS en el obeso con DM2. Conclusión: Los niveles de TBARS sugieren mayor daño por estrés oxidativo en DM2 obesos por un exceso en la producción de radicales libres (RL, así como incapacidad del SDA para delimitar el daño.

  3. 7th to 9th grade obese adolescents’ perceptions about obesity in tamaulipas, Mexico Percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado residentes en Tamaulipas, México Percepções da obesidade de adolescentes obesos, estudantes do 7º ao 9º grau residentes em Tamaulipas, México

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    Ma. de la Luz Martínez-Aguilar

    2010-02-01

    Full Text Available The objective was to explore obese adolescents’ perceptions about obesity among students in the seventh to ninth grade of a public school in Tamaulipas, Mexico. This is a qualitative study. Participants were 24 adolescents with a body mass index equal to or greater than the 95th percentile. Semistructured interviews were conducted until data saturation was reached and the meaning was understood. The adolescents defined obesity according to standards of measurement. They identified the hereditary factor as the main obesity cause, tended to underestimate obesity and had low self-esteem. They reported problems to do physical exercise and get clothes in order to improve their image, and feel rejected by their peers in school. It was identified that these adolescents have psychological defense mechanisms against obesity and that some of them are making efforts to lose weight. Obesity entails social and psychological health implications for persons suffering from this problem. Interventions should be put in practice.El objetivo de esta investigación fue explorar las percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado de una institución pública en Tamaulipas, México. Se trata de un estudio cualitativo en el cual participaron 24 adolescentes que tenían un índice de masa corporal superior al percentil 95. Se realizaron entrevistas semiestructuradas hasta obtener la saturación de los datos y la comprensión del significado. Los adolescentes definieron la obesidad de acuerdo a los estándares de medición, identificaron como causa principal el factor hereditario, tendieron a subestimar la obesidad y presentaron baja autoestima, relataron problemas cuando realizan actividad física y para conseguir ropa que pudiese mejorar su imagen, y se sienten rechazados por sus pares o iguales en la escuela. Se identificó que cuentan con mecanismos psicológicos de defensa ante la obesidad y algunos de ellos están realizando

  4. Broncoespasmo induzido pelo exercício em adolescentes asmáticos obesos e não-obesos Exercise-induced bronchospasm in obese and non-obese asthmatic adolescents

    OpenAIRE

    Wendell Arthur Lopes; Nelson Rosário; Neiva Leite

    2010-01-01

    OBJETIVO: Avaliar e comparar a frequência e intensidade do broncoespasmo induzido pelo exercício (BIE) em adolescentes asmáticos obesos e não-obesos. MÉTODOS: Estudo transversal e descritivo realizado com 39 adolescentes de ambos os sexos, com idade entre dez e 16 anos, divididos em dois grupos conforme o histórico clínico de asma e/ou rinite alérgica e o índice de massa corporal: asmáticos obesos (n=18); asmáticos não-obesos (n=21). Utilizou-se o teste de broncoprovocação com exercício para ...

  5. Mono Lake Excursion Reviewed

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.

    2007-05-01

    The Mono Lake Excursion as recorded in the Mono Basin, CA, has an older part that is about negative 30 degrees inclination and about 300 degrees declination during low relative field intensity. Those paleomagnetic directions are closely followed by greater than 80 degrees positive inclination and east declination of about 100 degrees during higher relative field intensity. A path of the Virtual Geomagnetic Poles (VGPs) for the older part followed from old to young forms a large clockwise loop that reaches 35 degrees N latitude and is centered at about 35 degrees E longitude. That loop is followed by a smaller one that is counterclockwise and centered at about 70 degrees N latitude and 270 degrees E longitude (Denham & Cox, 1971; Denham, 1974; Liddicoat & Coe, 1979). The Mono Lake Excursion outside the Mono Basin in western North America is recorded as nearly the full excursion at Summer Lake, OR (Negrini et al., 1984), and as the younger portion of steep positive inclination/east declination in the Lahontan Basin, NV. The overall relative field intensity during the Mono Lake Excursion in the Lahontan Basin mirrors very closely the relative field intensity in the Mono Basin (Liddicoat, 1992, 1996; Coe & Liddicoat, 1994). Using 14C and 40Ar/39Ar dates (Kent et al., 2002) and paleoclimate and relative paleointensity records (Zimmerman et al., 2006) for the Mono Lake Excursion in the Mono Basin, it has been proposed that the Mono Lake Excursion might be older than originally believed and instead be the Laschamp Excursion at about 40,000 yrs B.P. (Guillou et al., 2004). On the contrary, we favor a younger age for the Mono Lake Excursion, about 32,000 yrs B.P., using the relative paleointensity in the Mono Basin and Lahontan Basin and 14C dates from the Lahontan Basin (Benson et al., 2002). The age of about 32,000 yrs B.P. is also in accord with the age (32,000- 34,000 yrs B.P.) reported by Channell (2006) for the Mono Lake Excursion at ODP Site 919 in the Irminger Basin

  6. What's Mono?

    Science.gov (United States)

    ... Quizzes Kids' Dictionary of Medical Words En Español What Other Kids Are Reading Back-to-School Butterflies? ... Got Homework? Here's Help White House Lunch Recipes What's Mono? KidsHealth > For Kids > What's Mono? Print A ...

  7. Mono Test

    Science.gov (United States)

    ... white blood cells and reactive lymphocytes on a blood smear in the presence of symptoms associated with mono indicates a likely diagnosis of infectious mononucleosis. A negative mono test requires ...

  8. Escala de VO2pico em adolescentes obesos e não-Obesos por diferentes métodos Escala de VO2pico en adolescentes obesos y no obesos por diferentes métodos Scale of VO2peak in obese and non-obese adolescents by different methods

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    Gerusa Eisfeld Milano

    2009-12-01

    estrategia atractiva para comparar individuos con grandes diferencias en la masa corporal. OBJETIVO: Investigar el VO2pico en individuos obesos y no obesos usando el método de corrección de masa corporal (convencional y la escala alométrica (método alométrico y cómo esos métodos se aplican cuando individuos de ambos sexos se ejercitan en una cinta ergométrica. MÉTODOS: El VO2pico relativo al peso corporal y por el método alométrico fue comparado en 54 adolescentes obesos y 33 no obesos (10-16 años. Para evaluar el VO2pico durante un test máximo se utilizó calorimetría indirecta. El exponente alométrico fue calculado considerando la masa corporal individual. Así, el VO2pico fue corregido mediante el exponente alométrico. Las comparaciones se realizaron utilizando two-way ANOVA para medidas repetidas (p0,05. Sin embargo, el VO2pico calculado por el método convencional fue mayor (p0.05 entre los grupos. CONCLUSIÓN: Los individuos obesos presentaron VO2pico más bajo que los no obesos, al ser evaluados mediante el método convencional. Sin embargo, las diferencias desaparecieron cuando se aplicó el método de la escala alométrica.BACKGROUND: Peak oxygen uptake (VO2peak can be defined as the highest oxygen rate consumed during exhaustive or maximal exercise. The evaluation of the aerobic fitness can be expressed as relative to body mass, but this procedure may not fully remove differences when heavy subjects are assessed. Thus, the allometric scaling procedure is an attractive strategy to compare individuals with large differences in body mass. OBJECTIVE: Investigate VO2peak in obese and non-obese individuals using body mass correction (conventional and allometric scaling (allometric methods and how these methods apply when subjects of different genders exercise on a treadmill. METHODS: VO2peak relative to body weight and measured by the allometric method were compared in 54 obese and 33 non-obese adolescents (10 a 16 years. Indirect calorimetry was used to

  9. Respuesta al tratamiento periodontal de diabéticos tipo 2 con mal control metabólico y obesos intolerantes a la glucosa, con periodontitis severa Impact of the periodontal therapy in both clinical and metabolic parameters in type 2 diabetic and prediabetic obese patients with severe periodontitis

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    V Pavez Correa

    2011-08-01

    Full Text Available Diabetes Mellitus (DM es un factor de riesgo para periodontitis, a su vez, el control metabólico de los diabéticos se dificulta por la presencia de la infección periodontal, aumentando el riesgo de complicaciones crónicas y eventualmente, la mortalidad por diabetes. Ambas enfermedades se relacionan porque los mediadores de inflamación generados en la infección periodontal y la translocación de bacterias de la cavidad oral a la circulación sistémica, podrían actuar como agravantes de la insulino resistencia y deteriorar el control glicémico. Es evidente que el tratamiento oportuno de la periodontitis mejoraría la calidad de vida de los diabéticos; ayudándolos a alcanzar y mantener un adecuado control metabólico. El presente estudio evaluó el impacto de un protocolo de terapia periodontal en parámetros clínicos y metabólicos de pacientes DM2 y obesos prediabéticos, con el fin de contribuir a la inclusión de los diabéticos descompensados y prediabéticos en tratamientos periodontales exitosos, sin aumentar su riesgo médico. Se seleccionó a 9 individuos con DM2 descompensados y 7 obesos intolerantes a la glucosa, todos con Periodontitis Crónica Generalizada Severa. Los pacientes fueron sometidos a tratamiento periodontal, sin modificar las indicaciones médicas, de acuerdo a un protocolo diseñado por nosotros. Los diabéticos mostraron una leve disminución en la HbA1c a los 6 meses de realizado el tratamiento periodontal, no se registraron complicaciones, ni perdieron su condición de pacientes ambulatorios. La respuesta al tratamiento periodontal, fue similar en ambos grupos, con mejoría en todos los parámetros clínicos. Aunque los resultados obtenidos no son estadísticamente significativos, son muy promisorios.Diabetes Mellitus (DM is a risk factor for periodontitis, at the same time, the metabolic control of diabetic patients gets more difficult due to the presence of periodontal infection, increasing the risk of

  10. Aspectos socioeconómicos y familiares asociados en niños y adolescentes obesos

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    William José González Cabriles

    2013-01-01

    Full Text Available El estudio es transversal y correlacional donde se analizaron las variables socioeconómicas y familiares de una muestra no probabilística, constituida por 528 familias de niños con obesidad exógena, de 2 a 18 años, provenientes de diversos sectores del país, atendidos en la consulta de primera del Centro de Atención Nutricional Infantil Antímano. El objetivo fue determinar los aspectos socioeconómicos y familiares asociados en niños y adolescentes con obesidad que asistieron al Centro. Los datos se procesaron con el programa SPSS 9.0. Se analizaron las distribuciones de frecuencias y el estadístico Chi-cuadrado para probar asociación entre las variables. El nivel de significancia fue 95%. En las familias de niños obesos se encontró que la mayoría de los jefes de familia eran obesos; las familias con pobreza extrema y la población infantil mayor de 15 años presentaron mayor sedentarismo; por último, las madres en general no participaron en la toma de decisiones en la compra de alimentos y no poseían nociones de alimentación equilibrada que les permitieran planificar la compra de alimentos. Estos aspectos se erigen como claves para ser abordados y resueltos por el trabajador social durante la intervención con el fin de favorecer la recuperación nutricional del niño obeso y su familia.

  11. Installation of a mono pile as a foundation structure of a tidal turbine; Installation eines Monopfahls als Gruendungsstruktur fuer eine Gezeitenturbine

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Stefan [BAUER Spezialtiefbau GmbH, Schrobenhausen (Germany). Bautechnik; Bauer, Thomas [BAUER AG, Schrobenhausen (Germany)

    2012-11-01

    Tidal turbines enable a power generation from the flow energy of the sea. Usually heavy weight structures are used for the foundation of tidal turbines. However, these heavy weight structures are not fixed to the bottom of the sea. A mono pile being embedded in the bottom of the sea is an alternative which is a significant benefit for operators of tidal turbine operator.

  12. Estrés oxidativo, nitrosativo y daño cardiovascular en pacientes pediátricos obesos.

    OpenAIRE

    Tavárez Alonso, Sandra

    2015-01-01

    La obesidad predispone fuertemente al riesgo cardiovascular y se relaciona con alteraciones en diferentes marcadores de funcionalidad del tejido adiposo, inflamación y daño a biomoléculas. Establecer la presencia de alteraciones precoces en la obesidad infantil es el objetivo de este estudio realizado en pacientes pediátricos (7-14 años) obesos (N=60) y controles (N=42). En él hemos evaluado como marcadores de estrés oxidativo y nitrosativo los niveles de malondialdehído, 8-isoprostanos, pro...

  13. Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon

    DEFF Research Database (Denmark)

    Davidsen, Rasmus Schmidt; Schmidt, Michael Stenbæk; Boisen, Anja;

    2013-01-01

    of 200 μm. Reflectance measurements of the RIE-textured mono-, multi and quasi-mono Si surfaces were performed using a broadband lightsource (Mikropack DH-2000), an integrating sphere (Mikropack ISP-30-6-R), and a spectrometer (Ocean Optics QE65000, 280-1000 nm). The reference solar spectral irradiance......We use plasma etched Black Si (BS)[1][2] nanostructures to achieve low reflectance due to the resulting graded refractive index at the Si-air interface. The goal of this investigation is to develop a suitable texturing method for Si solar cells. Branz et al. [3]report below 3% average reflectance...... using maskless RIE in a O2 and SF6 plasma, and the surface topology was optimized for solar cell applications by varying gas flows, pressure, power and process time. The starting substrates were 156x156 mm p-type, CZ mono-, multi- and quasi-mono crystalline Si wafers, respectively, with a thickness...

  14. Diferencias clínicas y polisomnográficas entre obesos y no obesos con síndrome de apneas-hipopneas del sueño Clinical and polysomnographyc differences between obese and non obese patients with obstructive sleep apnea-hypopnea syndrome

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    Jorge Rey de Castro

    2011-12-01

    Full Text Available Objetivos. Describir las diferencias clínicas y polisomnográficas en pacientes obesos y no obesos con diagnóstico del síndrome de apneas-hipopneas del sueño (SAHS. Materiales y métodos. A los pacientes incluidos se les realizó un examen físico, se aplicó la escala de somnolencia de Epworth (ESE y además se les realizó una polisomnografía. Se consideró obeso si el índice de masa corporal (IMC era mayor o igual a 30 kg/m2. Resultados. Se analizaron 408 pacientes con SAHS, de estos, 119 (47 % fueron obesos. El SAHS fue leve en 101 (25 %, moderado en 91 (22 % y severo en 216 (53 %. No hubo diferencias por sexo, edad y puntaje ESE al compararse obesos con no obesos. La diferencias del perímetro cervical y presencia de somnolencia según ESE fue significativamente mayor en obesos. Estos tuvieron mayor comorbilidad en términos de dislipidemia, hipertensión arterial y enfermedad coronaria. De las variables polisomnográficas, los índices de eventos respiratorios fueron mayores en obesos, asimismo fueron peores los valores de saturación de oxígeno. No hubo diferencias en el resto de variables. El análisis de regresión mostró asociación entre la obesidad y la severidad del SAHS. Conclusiones. El SAHS no es una enfermedad limitada a la población obesa, aunque esta última tienen mayor comorbilidad y formas más severas de enfermedad.Objectives. To describe the clinical and polysomnographyc differences between obese and non- obese patients with obstructive sleep apnea-hypopnea (OSAH syndrome. Materials and methods. A physical examination, the Epworth Sleepiness Scale (ESS and a polysomnography were performed to all included patients. Obesity was defined as a body mass index (BMI of ≥ 30 kg/m2. Results. 408 patients with OSAH were analyzed, out of these, 119 (47 % were obese. OSAH was mild in 101 (25 %, moderate in 91 (22 % and severe in 216 (53 %. There were no age, sex and EES score differences between obese and non

  15. Efeitos de diferentes graus de sensibilidade a insulina na função endotelial de pacientes obesos

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    Roberto Galvão

    2012-01-01

    Full Text Available FUNDAMENTO: A obesidade derivada da deposição de gordura intra-abdominal tende a aumentar a produção de hormônios e citoquinas, piorando a sensibilidade a insulina e levando a disfunção endotelial. A hiperinsulinemia é considerada um fator de risco independente para doença isquêmica cardíaca e é uma causa de disfunção endotelial em indivíduos saudáveis. OBJETIVO: Avaliar o impacto de diferentes graus de resistência a insulina, medida pelo HOMA-IR (Homeostasis Model Assessment of Insulin Resistance, sobre a função endotelial de obesos, pacientes não diabéticos, sem história prévia de eventos cardiovasculares e diversos componentes da síndrome metabólica. MÉTODOS: Um total de 40 indivíduos obesos foi submetido a medidas antropométricas, pressão arterial de consultório, MAPA e exames laboratoriais, além de avaliação ultrassonográfica não invasiva da função endotelial. Os pacientes foram divididos em três grupos de acordo com o grau de resistência a insulina: pacientes com valores de HOMA-IR entre 0,590 e 1,082 foram incluídos no Grupo 1 (n = 13; entre 1,083 e 1,410 no Grupo 2 (n = 14; e entre 1,610 e 2,510 no Grupo 3 (n = 13. RESULTADOS: Encontramos uma diferença significativa na vasodilatação mediada por fluxo no Grupo 3 em relação ao Grupo 1 (9,2 ± 7,0 vs 18,0 ± 7,5 %, p = 0,006. Houve uma correlação negativa entre a função endotelial e insulina, HOMA-IR e triglicérides. CONCLUSÃO: Nosso estudo sugere que leves alterações nos níveis de resistência a insulina avaliada pelo HOMA-IR podem causar algum impacto sobre a função vasodilatadora do endotélio em indivíduos obesos não complicados com diferentes fatores de risco cardiovascular.

  16. Problemas clínicos pré-anestésicos de pacientes morbidamente obesos submetidos a cirurgias bariátricas: comparação com pacientes não obesos Problemas clínicos pré-anestésicos de pacientes mórbidamente obesos sometidos a cirugías bariátricas: comparación con pacientes no obesos Preanesthetic clinical problems of morbidly obese patients submitted to bariatric surgery: comparison with non-obese patiens

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    Getúlio Rodrigues de Oliveira Filho

    2002-04-01

    átricas, imponiendo nuevos desafíos al anestesiólogo. Este estudio comparó la prevalencia de problemas clínicos entre pacientes mórbidamente obesos sometidos a cirugías bariátricas y no obesos sometidos a otros procedimientos electivos. MÉTODO: Fueron estudiados, retrospectivamente, los registros electrónicos de 2986 pacientes divididos en grupo 1, obesos mórbidos sometidos a cirugías bariátricas y grupo 2, con índice de masa corporal menor que 30, sometidos a otros procedimientos electivos, relacionados al grupo 1 por la edad, sexo y estado físico (ASA. Los problemas pré-anestésicos del grupo 1 fueron pesquisados en el grupo 2 y las prevalencias comparadas. Las razones de chance (RC y respectivos limites de 95% de confianza (LC 95% fueron calculados. RESULTADOS: Los problemas identificados nos grupos 1 y 2 y sus respectivas prevalencias fueron: reflujo gastroesofágico (16,67% y 0,48%, hipertensión arterial sistémica (50% y 3,06%, diabetes mellitus tipo II (6,25% y 0,31%, hipotiroidismo (6,25% y 0,31%, asma bronquica (10,42% y 1,43% y pneumopatia restrictiva (10,42% y 0,03%. Las prevalencias fueron significativamente mas altas en el grupo 1. Fueron también identificados, en el grupo 1, los siguientes problemas que no fueron encontrados en el grupo 2: epilepsia (2,08%, esteatosis hepática (12,5%, colecistopatia calculosa (6,25%, dislipidemia (20,83% e hipopituitarismo (2,08%. CONCLUSIONES: La prevalencia de problemas clínicos es significativamente mas alta en pacientes portadores de obesidad mórbida de que en no obesos de la misma edad, sexo y estado físico.BACKGROUND AND OBJECTIVES: Morbid obesity is associated to clinical problems responsible for decreased life expectancy. Morbidly obese patients are candidates to gastric bypass and pose new challenges to the anesthesiologist. This study compared the prevalence of clinical problems among morbidly obese patients submitted to bariatric surgery to non-obese patients submitted to other elective surgical

  17. Broncoespasmo induzido pelo exercício em adolescentes asmáticos obesos e não-obesos Exercise-induced bronchospasm in obese and non-obese asthmatic adolescents

    Directory of Open Access Journals (Sweden)

    Wendell Arthur Lopes

    2010-03-01

    Full Text Available OBJETIVO: Avaliar e comparar a frequência e intensidade do broncoespasmo induzido pelo exercício (BIE em adolescentes asmáticos obesos e não-obesos. MÉTODOS: Estudo transversal e descritivo realizado com 39 adolescentes de ambos os sexos, com idade entre dez e 16 anos, divididos em dois grupos conforme o histórico clínico de asma e/ou rinite alérgica e o índice de massa corporal: asmáticos obesos (n=18; asmáticos não-obesos (n=21. Utilizou-se o teste de broncoprovocação com exercício para a avaliação do BIE, considerando-se positiva uma diminuição do volume expiratório forçado no primeiro segundo (VEF1 >15% do valor pré-exercício. Para avaliar a intensidade e a recuperação do BIE, foram calculadas a queda percentual máxima do VEF1 (QM%VEF1 e a área acima da curva (AAC0-30. A análise estatística utilizou o teste exato de Fischer para comparar a frequência de BIE e o teste de Mann-Whitney para a intensidade e recuperação. Rejeitou-se a hipótese de nulidade se pOBJECTIVE: To assess and compare the frequency and severity of exercise-induced bronchospasm (EIB in obese and non-obese asthmatic adolescents. METHODS: Cross-sectional and descriptive study with 39 subjects aged ten to 16 years of both genders divided into two groups according to clinical history of asthma and/or allergic rhinitis and body mass index, as follows: asthmatic obese (n=18 and asthmatic non-obese (n=21. An exercise bronchoprovocation test was applied to diagnose EIB and was considered positive if the forced expiratory volume in one second (FEV1 decreased >15% in relation to pre-exercise FEV1. Maximum percent of fall in FEV1 (MF%FEV1 and the area above the curve (AAC0-30 were calculated to evaluate the intensity and recovery of EIB. Fisher exact test was used to compare the frequency of EIB and Mann-Whitney test to compare the severity and recovery of EIB. Null hypothesis was rejected when p<0.05. RESULTS: No significant difference was found in

  18. Aleitamento materno exclusivo atenua riscos cardiovasculares e estado inflamatório em adolescentes obesos

    OpenAIRE

    Masquio, Deborah Cristina Landi; de Piano, Aline; Claudia Cristina Alves PEREIRA; Sanches, Priscila de Lima; Campos, Raquel Munhoz da Silveira; Carnier, June; Oyama, Lila Missae; Tufik, Sergio; de Mello, Marco Túlio; Dâmaso, Ana

    2014-01-01

    Objetivo: Verificar o perfil inflamatório e o risco de doenças das artérias carótidas em adolescentes obesos de acordo com tempo de aleitamento materno exclusivo na infância, Métodos: Trata-se de estudo transversal realizado com 118 adolescentes obesos, A duração do aleitamento materno exclusivo foi obtida por meio de entrevista com os pais, A espessura da íntima-média da artéria carótida (EIMc) foi estimada por ultrassonografia, Massa corporal, Índice de Massa Corporal (IMC), Circunferência ...

  19. Estudio de las funciones ejecutivas en sujetos obesos con trastorno de la conducta alimentaria

    OpenAIRE

    Ribeiro, Fátima Cristina da Silva

    2013-01-01

    [ES] El objetivo de este estudio fue estudiar las funciones ejecutivas y sus diferentes componentes en sujetos obesos con y sin Trastorno por Atracón (TA), comparándolos con sujetos normoponderales sin Trastornos de la Conducta Alimentaria (TCA), de características sociodemográficas similares; analizar las actividades de la vida diaria y calidad de vida en los sujetos obesos con y sin TA y, evaluar el impacto que tiene el funcionamiento ejecutivo sobre las actividades de la vida diaria y cali...

  20. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2

    Directory of Open Access Journals (Sweden)

    Cabrera-Pivaral Carlos Enrique

    2004-01-01

    Full Text Available La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos de pacientes diabéticos obesos. La intervención educativa-participativa se organizó mediante el proceso de reflexión-acción. Se efectuaron mediciones del IMC basal y mensuales durante los 9 meses de la intervención educativa. Los grupos fueron controlados tomando en cuenta edad y sexo. El análisis estadístico se efectuó con el estadígrafo de t de students con diferencia de media para grupos relacionados. El grupo control logra un valor promedio de IMC basal de 33.89 ± 1.96 y al final de 33.2 ± 2.15 (t: 22.4; p: 0.16, el grupo de experimento con valor inicial de 33.63 ± 2.12 y final de 31.54 ± 1.71 (t: 11.55; p = 0.003. La intervención educativa participativa contribuye a mejorar el nivel de IMC en los diabéticos obesos 2.

  1. Perfiles psicopatológicos de niños obesos y desnutridos medidos con el CBCL/6-18

    Directory of Open Access Journals (Sweden)

    Verónica Portillo-Reyes

    2016-01-01

    Full Text Available Los objetivos de este trabajo fueron definir los trastornos psicopatológicos más comunes asociados a la obesidad y a la desnutrición, así como establecer el grupo de referencia normativo al cual pertenece México en la escala Child Behavior Checklist 6-18 (CBCL/6-18. Este fue un estudio transversal de dise˜no cuasiexperiemental. Se utilizó la información de 125 ni˜nos de escuelas públicas de Ciudad Juárez, Chihuahua, México, en estados de desnutrición, obesidad y normopeso, obtenida mediante las 113 preguntas relacionadas con el comportamiento de ni˜nos, que contiene el CBCL 6-18. Por medio de análisis de varianzas se estudiaron las posibles diferencias entre los grupos. Encontramos que nuestra muestra mexicana, pertenece al grupo normativo de referencia tres; las diferencias más significativas se encuentran en el grupo de obesos en las escala de problemas internalizados específicamente en ansiedad/depresión, y en el total de problemas.

  2. Considerações acerca da avaliação psicológica das comorbidades psiquiátricas em obesos Consideraciones sobre la evaluación psicológica de las comorbidades psiquiátricas en obesos Consideration about psychological assessment of psychiatric co morbidity in obese

    Directory of Open Access Journals (Sweden)

    Fabiana Silva Costa

    2009-06-01

    Full Text Available Pretende-se neste artigo apresentar uma revisão teórica sobre avaliação psicológica, obesidade e comorbidades psiquiátricas mais frequentes na população obesa. A obesidade é uma doença clínica de múltiplas causas, e atualmente é considerada uma epidemia; assim seu adequado entendimento deve envolver uma equipe composta por diversos profissionais de saúde, incluindo o psicólogo. Serão abordadas questões pertinentes ao tema de obesidade, como etiologia, incidência e a relação entre obesidade e transtornos psiquiátricos. Serão propostos alguns instrumentos com o objetivo de estruturar informações necessárias ao tratamento e à demanda do paciente obeso, e reflexões referentes à avaliação psicológica em obesos e a prática do profissional de psicologia.Se pretiende en ese artículo presentar una revisión teórica sobre la evaluación psicológica, obesidad y comorbidades psiquiátricas más frecuentes en esa población. La obesidad es una enfermedad clínica con diversas causas y actualmente es considerada una epidemia, así el adecuado entendimiento de la obesidad debe involucrar un equipo compuesto por diversos profesionales de salud, incluso el psicólogo. En ese artículo serán abordadas cuestiones pertinentes a la temática de la obesidad, como etiología, prevalencia y la relación entre obesidad y los trastornos psiquiátricos. Serán propuestos algunos instrumentos* con el objetivo de estructurar informaciones necesarias al tratamiento y a la demanda del paciente obeso, reflexiones referentes a la evaluación psicológica en obesos y la práctica del profesional de PsicologíaWe intend in this article to present a theoretical review about psychological assessment, obesity and psychiatric co morbidity. Obesity is a clinical illness, it has multi factorial causes, and nowadays it is considered an epidemic, so the right knowledge must involve all health professional, include the psychologist. In this article we

  3. Efectividad del tratamiento con acupuntura de pacientes obesos en rehabilitación cardiovascular

    OpenAIRE

    Vanegas Santana, Domingo Eliécer

    2009-01-01

    La obesidad es un factor independiente de riesgo cardiovascular, la pérdida de peso mejora los factores de riesgo cardiovascular asociados. Se propone evaluar la inclusión de la Acupuntura en el abordaje interdisciplinario de pacientes obesos con riesgo cardiovascular, realizando el discernimiento de los diagnósticos de acuerdo a la medicina china, describiendo las determinaciones de laboratorio (colesterol, triglicéridos, glicemia), el comportamiento de constantes vitales (presión arterial, ...

  4. Well-defined mono(η3-allyl)nickel complex MONi(η3-C3H5) (M = Si or Al) grafted onto silica or alumina: A molecularly dispersed nickel precursor for syntheses of supported small size nickel nanoparticles

    KAUST Repository

    Li, Lidong

    2014-01-01

    Preparing evenly-dispersed small size nickel nanoparticles over inert oxides remains a challenge today. In this context, a versatile method to prepare supported small size nickel nanoparticles (ca. 1-3 nm) with narrow size distribution via a surface organometallic chemistry (SOMC) route is described. The grafted mono(η3-allyl)nickel complexes MONi(η 3-C3H5) (M = Si or Al) as precursors are synthesized and fully characterized by elemental analysis, FTIR spectroscopy and paramagnetic solid-state NMR. © 2014 the Partner Organisations.

  5. Método do limiar de variabilidade da frequência cardíaca aplicado em pré-adolescentes obesos e não obesos

    Directory of Open Access Journals (Sweden)

    Mário Augusto Paschoal

    2011-06-01

    Full Text Available FUNDAMENTO: A detecção do limiar anaeróbico (LA pela análise da variabilidade da frequência cardíaca (LiVFC pode significar uma nova maneira de avaliação da capacidade funcional cardiorrespiratória (CFCR em pré-adolescentes. OBJETIVO: Testar o método de LiVFC para detecção do LA em pré-adolescentes não obesos (NO, obesos (O e obesos mórbidas (OM, a fim de determinar diferenças em sua CFCR. MÉTODOS: Foram estudados 30 pré-adolescentes, com idades entre 9 e 11 anos, divididos em três grupos de 10: a grupo NO - índice de massa corpórea (IMC com percentil do National Center for Chronic Disease Prevention and Health Promotion entre 5 e 85; b grupo O - IMC de percentil entre 95 e 97 e c grupo OM - IMC com percentil acima de 97. Todos foram submetidos a um protocolo incremental realizado em esteira rolante e registraram-se os batimentos cardíacos para detecção do LiVFC, que foi determinado pelo valor de 3,0 ms do índice do desvio-padrão 1 (SD1, extraído dos intervalos RR. RESULTADOS: Os valores médios no momento do LiVFC mostraram maiores valores para o grupo NO, destacando-se: a VO2 (ml/kg/min NO = 27,4 ± 9,2; O = 13,1 ± 7,6 e OM = 11,0 ± 1,7; b FC (bpm: NO = 156,3 ± 18,0; O =141,7 ± 11,4 e OM = 137,7 ± 10,4; e c distância percorrida (metros: NO = 1.194,9 ± 427,7; O = 503,2 ± 437,5 e OM = 399,9 ± 185,1. CONCLUSÃO: O LiVFC se mostrou efetivo para avaliação da CFCR e poderá vir a ser aplicado como método alternativo à ergoespirometria em determinadas situações.

  6. Discriminação contra os estudantes obesos e os muito magros nas escolas Brasileiras

    OpenAIRE

    Kubota, Luis Claudio

    2014-01-01

    A Pesquisa Nacional de Saúde do Escolar (PeNSE) 2012, realizada pelo Instituto Brasileiro de Geografia e Estatística (IBGE), em parceria com o Ministério da Saúde (MS), abrange um amplo leque de assuntos, com destaque para comportamentos de risco. Este artigo tem o objetivo de analisar a discriminação contra estudantes obesos e muito magros, utilizando microdados da PeNSE. Os dados indicam que alunos que se autoclassificam “muito gordos” ou “muito magros” são muito mais propensos a comportame...

  7. Festival nimega Mono / Ivar Sakk

    Index Scriptorium Estoniae

    Sakk, Ivar, 1962-

    2015-01-01

    Haapsalu graafilise disaini festival Haapsalu Linnagaleriis: sisaldab ülevaate- ja teemanäitust ning väikest sümpoosioni. Temaatilise aastanäituse motiiv on "MONO". Plakateid on ka välismaa tegijatelt. Kuraator Marko Kekishev

  8. Acupuntura e apetite de trabalhadores obesos de um hospital universitário Acupuntura y apetito de trabajadores obesos de un hospital universitario Acupuncture and appetite in obese employees of a university hospital

    Directory of Open Access Journals (Sweden)

    Mariana Lourenço Haddad

    2011-01-01

    Full Text Available OBJETIVO: Mensurar o comportamento da sensação de apetite dos sujeitos antes, durante e após a intervenção de acupuntura. MÉTODOS: Estudo descritivo exploratório. A coleta de dados ocorreu em um hospital universitário em Maringá - PR, entre julho e outubro de 2009, com 37 trabalhadores obesos, que receberam oito sessões semanais de acupuntura. Para mensuração do apetite, foram utilizadas as Escalas Visuais Analógicas. RESULTADOS: Demonstraram que o comportamento do apetite em relação à saciedade, plenitude, desejo por alimentos doces e palatáveis sofreu modificações durante a intervenção. Não houve redução de peso ou índice de massa corpórea dos sujeitos, contudo observou-se redução significativa na razão cintura-quadril (p=0,02 e controle no hábito de consumir alimento consolo. CONCLUSÃO: Os achados do estudo podem contribuir para a formação do corpo de conhecimento da acupuntura voltada à saúde do trabalhador, sobretudo nos aspectos relacionados à obesidade, suas comorbidades e fatores desencadeantes.OBJETIVO: Mensurar el comportamiento de la sensación de apetito de los sujetos antes, durante y después de la intervención de acupuntura. MÉTODOS: se trata de un estudio descriptivo exploratorio. La recolección de datos se llevó a cabo en un hospital universitario en Maringá PR, entre julio y octubre del 2009, con 37 trabajadores obesos, que recibieron ocho sesiones semanales de acupuntura. Para la mensuración del apetito, fueron utilizadas las Escalas Visuales Analógicas. RESULTADOS: Demostraron que el comportamiento del apetito en relación a la saciedad, plenitud, deseo de alimentos dulces y agradables al paladar sufrió modificaciones durante la intervención. No hubo reducción de peso o índice de masa corporal de los sujetos, con todo se observó reducción significativa en la razón cintura-cadera (p=0,02 y control en el hábito de consumir alimento consuelo. CONCLUSIÓN: Los hallazgos del

  9. A percepção de saúde para adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Maria das Graças Carvalho Ferriani

    2000-12-01

    Full Text Available O presente estudo tem como objetivo conhecer a percepção de saúde para adolescentes obesos que participam do Programa Multidiciplinar de Assistência ao Adolescente Obeso, desenvolvido no Campus de Ribeirão Preto - USP. Foi utilizada a abordagem qualitativa fundamentada em Minayo (1996; os dados foram coletados através de frases e redações de 17 adolescentes integrantes do programa. A análise e interpretação dos dados foi ancorada na técnica de análise temática proposta por Bardin (1977, onde identificou-se os seguintes núcleos de sentido: saúde é beleza, alimentação e higiene e prática de esportes. Assim, o estudo evidenciou que a imagem corporal ideal que o adolescente busca para si, está relacionada com os padrões de beleza ditados pela mídia e com estereótipos de perfeição física. Outro aspecto detectado no estudo, é que os adolescentes têm consciência da importância de praticar esportes e ter uma alimentação balanceada.

  10. Aterosclerose subclínica e marcadores inflamatórios em crianças e adolescentes obesos e não obesos Atherosclerosis subclinical and inflammatory markers in obese and nonobese children and adolescents

    Directory of Open Access Journals (Sweden)

    Larissa R. Silva

    2012-12-01

    Full Text Available OBJETIVO: Realizou-se revisão sistemática sobre espessamento médio-intimal (EMI e marcadores inflamatórios, comparou-se EMI por metanálise e analisou-se a correlação entre EMI e variáveis inflamatórias em crianças e adolescentes obesos e não obesos. FONTES DOS DADOS: Buscaram-se artigos nas bases de dados Pubmed, Bireme e Science Direct, nos anos de 2000 a 2010, com as seguintes palavras-chave em inglês: "obesity", "adolescents", "atherosclerosis" e "child", sendo utilizados em duas combinações: obesity+adolescents+atherosclerosis e obesity+child+atherosclerosis. Utilizou-se meta-análise para comparar EMI entre obesos e não obesos. SINTESE DOS DADOS: Selecionou-se criteriosamente 16 artigos para análise final. Houve diferença da espessura de EMI entre obesos e não obesos em 12 estudos, confirmada pela meta-análise. Os obesos apresentaram concentrações de proteína C-reativa mais elevada em 13 artigos analisados (p We conducted a systematic review of intima-media thickness(IMT and inflammatory markers, compared IMT and identified by meta-analysis related to EMI and inflammatory variables in obese and non-obese children and adolescents. We searched for articles in databases Pubmed, Bireme and Science Direct, during years 2000 to 2010, with the following key words in English: "obesity", "adolescents", "atherosclerosis" and "child ", They were used in two combinations: obesity + adolescents + atherosclerosis + child + obesity and atherosclerosis. We used meta-analysis to compare IMT between obese and non-obese patients. We carefully selected 16 articles for final analysis. There were differences in the thickness of IMT between obese and non-obese patients in 12 studies, confirmed by meta-analysis. Obese patients had concentrations of C-reactive protein higher in 13 articles analyzed (p < 0.05 and lower adiponectin levels in 4 (p < 0.05. In general, obese men had lower concentrations of adiponectin and higher values of IMT and C

  11. Viscoelasticity of mono- and polydisperse inverse ferrofluids.

    Science.gov (United States)

    Saldivar-Guerrero, Ruben; Richter, Reinhard; Rehberg, Ingo; Aksel, Nuri; Heymann, Lutz; Rodriguez-Fernández, Oliverio S

    2006-08-28

    We report on measurements of a magnetorheological model fluid created by dispersing nonmagnetic microparticles of polystyrene in a commercial ferrofluid. The linear viscoelastic properties as a function of magnetic field strength, particle size, and particle size distribution are studied by oscillatory measurements. We compare the results with a magnetostatic theory proposed by De Gans et al. [Phys. Rev. E 60, 4518 (1999)] for the case of gap spanning chains of particles. We observe these chain structures via a long distance microscope. For monodisperse particles we find good agreement of the measured storage modulus with theory, even for an extended range, where the linear magnetization law is no longer strictly valid. Moreover we compare for the first time results for mono- and polydisperse particles. For the latter, we observe an enhanced storage modulus in the linear regime of the magnetization. PMID:16965057

  12. Prevalencia de hiperlipidemia e hiperglicemia en niños obesos: ¿riesgo aumentado de enfermedad cardiovascular?

    Directory of Open Access Journals (Sweden)

    M. Marcano

    2006-08-01

    Full Text Available Las enfermedades cardiovasculares representan la primera causa de muerte en Venezuela desde el año 1967. Existen evidencias que demuestran que la lesión temprana de la aterosclerosis coronaria se inicia en la infancia con marcada asociación a la obesidad y diabetes, por lo que su prevención debe iniciarse en esa época. Objetivo: Estudiar la presencia de hiperlipidemia e hiperglicemia en niños obesos como indicadores de riesgo. Metodología: Se seleccionaron 121 niños (edad 8,7±3,43 años, con índice de masa corporal mayor al P90 para su edad (Fundacredesa. Se determinó colesterol sérico total y fracciones (HDL-C y LDL-C, triglicéridos y glicemia en ayunas por métodos enzimáticos-colorimétricos.Se utilizaron puntos de corte para colesterol y triglicéridos según referencia nacional (Fundacredesa, para las LDL-C y HDL-C, los criterios del National Cholesterol Education Program y para glicemia según la American Diabetes Association. La muestra se agrupó por edad en: 2-5,11 años (19%: Grupo 1; 6-8,11 años (28,1%: Grupo 2 y mayores de 9 años (52,9%: Grupo 3. Análisis estadístico por genero y grupo etario. Resultados: El colesterol se ubicó en "riesgo" en los varones Grupo 1. Las HDL-C en riesgo en las niñas de Grupo 1 y Grupo 3 y en los varones Grupo 3. Los triglicéridos, se ubicaron en niveles de "riesgo" para las niñas Grupo 1 y Grupo 3 y varones Grupo 2 y en rango "elevado" en los varones Grupo 1 y Grupo 3. Las LDL-C, se ubicaron en todos los grupos en rango "aceptable" y no se encontró hiperglicemia en los niños evaluados. Conclusión: El perfil bajo de HDL y elevado de triglicéridos, sugiere un mayor riesgo de estos niños obesos a enfermedad cardiovascular, con mayor afectación en el género masculino. Una elevada proporción de ellos cumple con tres criterios definitorios de Síndrome metabólico por lo que se recomienda control dietario y modificaciones en el patrón de alimentación y de actividad física.

  13. Métodos de análise da composição corporal em adultos obesos

    Directory of Open Access Journals (Sweden)

    Rávila Graziany Machado de Souza

    2014-10-01

    Full Text Available Os métodos de avaliação da composição corporal em obesos têm sido amplamente discutidos, uma vez que nesses indivíduos a avaliação é dificultada devido às limitações dos equipamentos e características dos métodos utilizados. Esta sessão temática tem o objetivo de esclarecer as características, vantagens e limitações dos métodos de avaliação da composição corporal em adultos obesos. A quantificação de gordura corporal e mas-sa livre de gordura, assim como a avaliação da perda de massa muscular e de massa óssea em obesos são temas de grande interesse científico, uma vez que são utilizados para diagnosticar a obesidade osteosarcopênica. A avaliação da composição corporal de obesos pelo modelo de múltiplos compartimentos é padrão-ouro na prática científica. Por outro lado, o método de absorciometria radiológica de feixe duplo é considerado o padrão de referência em pesquisas e na prática clínica. Estudos indicam que a ressonância magnética e a tomografia computadorizada, em alguns casos, são fortemente correlacionadas com a absorciometria radiológica de feixe duplo. Os demais métodos apresentam limitações em avaliar a composição corporal, bem como suas modificações durante a redução ponderal em indivíduos obesos.

  14. Aleitamento materno exclusivo atenua riscos cardiovasculares e estado inflamatório em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Deborah Cristina Landi MASQUIO

    2014-01-01

    Full Text Available Objetivo: Verificar o perfil inflamatório e o risco de doenças das artérias carótidas em adolescentes obesos de acordo com tempo de aleitamento materno exclusivo na infância, Métodos: Trata-se de estudo transversal realizado com 118 adolescentes obesos, A duração do aleitamento materno exclusivo foi obtida por meio de entrevista com os pais, A espessura da íntima-média da artéria carótida (EIMc foi estimada por ultrassonografia, Massa corporal, Índice de Massa Corporal (IMC, Circunferência da Cintura (CC e pressão arterial foram mensurados, Dosagens séricas de glicose, insulina, colesterol total, LDL, adiponectina e leptina foram realizadas, A resistência insulínica foi determinada por meio do Homeostasis Model Assessment Insulin Resistance (HOMA-IR, Resultados: Adiponectina apresentou-se significativamente superior em adolescentes amamentados exclusivamente até os 6 meses, Por outro lado, a EIMc mostrou-se significativamente inferior nesses adolescentes, Massa corporal, IMC, gordura corporal, CC, insulina e HOMA-IR apresentaram-se significativamente inferiores em adolescentes que receberam aleitamento materno exclusivo até os seis meses comparados aos que não receberam, Insulina e HOMA-IR associaram-se com a massa corporal, IMC, CC e gordura corporal, As concentrações de leptina associaram-se negativamente com adiponectina e positivamente com gordura corporal e IMC, Pressão arterial sistólica e diastólica foram preditas positivamente pela massa corporal, IMC e CC, Conclusão: Adolescentes obesos amamentados exclusivamente por 6 meses apresentam um perfil antropométrico e metabólico e estado inflamatório mais atenuado, bem como menores riscos cardiovasculares, o que pode contribuir para redução de riscos de desenvolvimento de aterosclerose em longo prazo.

  15. Percepção do adolescente obeso sobre as repercussões da obesidade em sua saúde Percepción de los adolescentes obesos respecto de los efectos de la obesidad en su salud Obese adolescents' perceptions about the repercussions of obesity on their health

    Directory of Open Access Journals (Sweden)

    Solange Queiroga Serrano

    2010-03-01

    Full Text Available O objetivo deste estudo é avaliar a percepção do adolescente obeso sobre as repercussões da obesidade em sua saúde. Baseou-se no relato de quinze adolescentes obesos, acompanhados no Ambulatório do Hospital das Clínicas da Universidade Federal de Pernambuco, no período de abril a julho de 2007. Os depoimentos, obtidos através de entrevista semi-estruturada, foram submetidos à análise de conteúdo, modalidade temática transversal. Foram identificadas quatro temáticas relacionadas com os objetivos do estudo: 1. A percepção do conceito de obesidade; 2. A obesidade afetando a auto-imagem; 3. Obesidade versus Saúde e 4. O difícil retorno à saúde. Os adolescentes perceberam a obesidade como doença, repercutindo negativamente sobre sua saúde, apresentando uma baixa auto-estima e a sensação de isolamento. Reconhecem que ser saudável é ter uma alimentação correta e praticar atividade física, sendo imprescindível o apoio formal e informal, sobrepujando as dificuldades para manter uma qualidade de vida satisfatória.El objetivo de este estudio es evaluar la percepción del adolescente obeso respecto de los efectos de la obesidad en su salud. Se basó en el relato de quince adolescentes obesos que recibían seguimiento médico en el Ambulatorio del Hospital das Clínicas da Universidade Federal de Pernambuco, utilizándose el método de entrevista semiestructurada, en el período de abril a julio de 2007. Los testimonios obtenidos de las grabaciones transcriptas fueron sometidos al método de análisis de contenido, modalidad temática transversal. Se identificaron cuatro temáticas relacionadas con los objetivos del estudio: 1. La percepción del concepto de obesidad, 2. La obesidad afectando la autoimagen, 3. Obesidad versus salud, y 4. El difícil retorno a la salud. Los adolescentes reconocieron a la obesidad como una enfermedad que acarrea repercusiones negativas en su salud, generándoles una baja autoestima y sensaci

  16. Modelo educativo nutricional para la reducción de factores de riesgo cardiovascular en niños escolares obesos

    Directory of Open Access Journals (Sweden)

    María del Pilar Suárez de Ronderos

    2003-07-01

    Full Text Available El objetivo de esta investigación fue evaluar la efectividad de un modelo de educación nutricional para la reducción de factores de riesgo de enfermedad cardiovascular en niños escolares obesos. Se realizó un diagnóstico previo para identificar las características generales de este grupo de niños y determinar el estado nutricional, los conocimientos, las actitudes y las prácticas alimentarlas relacionadas con factores de riesgo cardiovascular. El estudio de tipo casi experimental incluyó 31 niños obesos divididos en dos grupos: 15 casos y 16 controles. Todos los niños tenían entre 7 y 12 años, con obesidad, y remitidos por médicos de la consulta externa del Hospital Nacional de Niños. En los casos se implementó el modelo educativo, el cual contempló la participación de padres y niños con metodología participativa diseñada para niños en edad escolar. El modelo incluye 5 sesiones educativas en las que se utiliza un libro de actividades, cuentos y juegos. Los resultados de la intervención fueron evaluados tres meses después de la intervención educativa. Los resultados muestran que la mayoría de los niños presentaron antecedentes de Diabetes Mellitus, bajos niveles socioeconómicos, sedentarismo, así como dislipidemia el 97%. El 97% de los niños evaluados presenta al menos 2 factores de riesgo de enfermedad cardiovascular. El análisis de la dieta reportó disgusto por el consumo de frutas y vegetales e inadecuado consumo de macronutrientes y micronutrientes. También se identificaron inadecuados conocimientos relacionados con la alimentación adecuada para la prevención de enfermedad cardiovascular, así como trastornos de baja autoestima. El modelo educativo elaborado fue efectivo en el grupo intervenido, al mostrar cambios significativos las variables analizadas.

  17. Manobra de recrutamento alveolar e suporte ventilatorio perioperatorio em pacientes obesos submetidos a cirurgia abdominal

    OpenAIRE

    Luiz Alberto Forgiarini Junior; Juliana Castilhos Rezende; Soraia Genebra Ibrahim Forgiarini

    2013-01-01

    O desenvolvimento da cirurgia abdominal proporcionou uma alternativa terapêutica para obesos mórbidos; entretanto, os pacientes submetidos a esse procedimento frequentemente apresentam complicações pulmonares pós-operatórias. Uma possível alternativa para a redução dessas complicações é a utilização da manobra de recrutamento alveolar e/ou estratégias ventilatórias perioperatórias, com foco na redução das complicações pulmonares pós-operatórias. Nesta revisão, são descritos os benefícios de e...

  18. Percepción de la propia imagen corporal en pacientes obesos o con sobrepeso.

    Directory of Open Access Journals (Sweden)

    Faustino Abad Massanet

    2012-08-01

    Full Text Available La obesidad es un importante problema de salud en la comunidad, y su abordaje es complejo. La valoración de la propia imagen corporal podría ser de ayuda, en pacientes obesos o con sobrepeso, para orientar hacia la obtención de un peso más saludable. Con este objetivo se utilizó una escala de figuras (escala de Stunkard en pacientes de estas características, comparando la figura seleccionada por cada participante con la correspondiente a su Índice de Masa Corporal real. La concordancia entre ambas fue escasa, con marcado predominio de sujetos que infravaloran su IMC. El error en la valoración fue significativamente mayor entre las mujeres, en los participantes con menor nivel de estudios, y entre los que presentaban algún componente del síndrome metabólico.

  19. Aterosclerose subclínica e marcadores inflamatórios em crianças e adolescentes obesos e não obesos Atherosclerosis subclinical and inflammatory markers in obese and nonobese children and adolescents

    OpenAIRE

    Larissa R. Silva; Joice M.F. Stefanello; Juliana Pizzi; Luciana S. Timossi; Neiva Leite

    2012-01-01

    OBJETIVO: Realizou-se revisão sistemática sobre espessamento médio-intimal (EMI) e marcadores inflamatórios, comparou-se EMI por metanálise e analisou-se a correlação entre EMI e variáveis inflamatórias em crianças e adolescentes obesos e não obesos. FONTES DOS DADOS: Buscaram-se artigos nas bases de dados Pubmed, Bireme e Science Direct, nos anos de 2000 a 2010, com as seguintes palavras-chave em inglês: "obesity", "adolescents", "atherosclerosis" e "child", sendo utilizados em duas combinaç...

  20. Synthesis of mono-, di-, tri-, and tetraethyl-o-carboranes by electrophilic alkylation of o-carborane with ethyl bromide in the presence of AlCl3 and their transformations

    International Nuclear Information System (INIS)

    Optimal conditions for preparation of 9-ethyl-, 9,12-diethyl, 8,9,12-triethyl- and 8,9,10,12-tetraethyl-o-carboranes under the action of EtBr on o-carborane in the presence of AlCl3 were determined. The behavior of these o-carborane derivatives with respect to electrophilic and nucleophilic reagents was studied. 17 refs.; 3 tabs

  1. Mono Digital Wordlist: Presentation Form

    Directory of Open Access Journals (Sweden)

    Kenneth S. Olson

    2009-01-01

    Full Text Available This paper presents a 204-item digital wordlist of Mono, an Ubangian language spoken in the Democratic Republic of the Congo. The wordlist includes orthographic and broad phonetic transcriptions of each word, French and English glosses, an individual WAV recording of each item, GIF images of the original field transcriptions, and metadata for resource discovery. An archival form of the wordlist was deposited into an institutional archive (the SIL Language and Culture Archives and includes the original WAV digital recording, descriptive markup encoding of the wordlist in XML employing Unicode 5.1 transcription, TIFF images of the original field transcriptions, and the metadata record. The presentation form was then generated directly from the archival form.

  2. Influencia do indice de massa corporal no equilibrio e na configuracao plantar em obesos adultos

    Directory of Open Access Journals (Sweden)

    Liu Chiao Yi

    2014-01-01

    Full Text Available INTRODUÇÃO: A obesidade é uma doença crônica degenerativa multifatorial que pode levar a alterações do sistema musculoesquelético, como mudança do centro de gravidade e sobrecarga mecânica sobre os membros inferiores. OBJETIVOS: Correlacionar o índice de massa corporal (IMC com o equilíbrio corporal e verificar associação entre o IMC e a configuração plantar. MÉTODOS: Foram avaliados 30 obesos, de ambos os gêneros, com IMC maior ou igual a 30 Kg/m². Inicialmente, os voluntários foram submetidos às avaliações de medidas antropométricas a fim de calcular o valor do IMC. Em seguida, foram submetidos ao teste de equilíbrio corporal estático Balance Error Scoring System (BESS e a plantigrafia para a identificação da impressão plantar. Por meio do método de Viladot, os voluntários foram classificados em grupos: pé plano (GPP, pé cavo (GPC e pé neutro (GPN. A correlação entre as variáveis IMC e BESS foi calculada por meio do coeficiente de correlação linear de Pearson e associação entre o IMC e a configuração plantar foi realizada por meio da análise de variância (Anova. Para todas as análises, nível de significância considerado foi p < 0,05. RESULTADOS: Os valores da correlação entre o IMC e o BESS foram r = - 0,1 e p = 0,59. Os valores da associação do IMC entre GPN - GPP; GPN - GPC; GPP - GPC foram respectivamente: p = 0,76; p = 0,001; p = 0,07. CONCLUSÃO: O índice de massa corporal de adultos obesos não influencia o equilíbrio corporal, porém influencia na configuração plantar.

  3. Características miofuncionais e eletromiográficas de crianças e adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Denise Bolzan Berlese

    2013-08-01

    Full Text Available OBJETIVO: investigar as características miofuncionais e eletromiográficas de obesos em relação ao sexo e faixa de idade. MÉTODO: amostra de conveniência de 28 crianças e adolescentes obesos, de ambos os sexos, participantes do grupo de Obesidade do Ambulatório de Pediatria do Hospital Universitário do Hospital Universitário de Santa Maria, no período de janeiro a julho de 2011. As características Miofuncionais foram realizadas por fonoaudióloga experiente por meio do Protocolo de Avaliação Miofuncional com Escores (AMIOFE. A avaliação eletromiografica dos músculos masseter e temporal foi obtida utilizando o Eletromiógrafo Lynx e realizada três coletas para cada uma das situações (repouso, mastigação, deglutição e máxima intercuspidação. Os dados eletromiográficos foram normalizados, expressos em percentual, utilizando-se a média da máxima intercuspidação de cada músculo estudado nas avaliações realizadas. RESULTADOS: a maioria dos obesos desta pesquisa apresentaram características miofuncionais dentro da normalidade, não sendo observada diferença estatística significante quando comparados por sexo e idade. Embora a média normalizada da atividade elétrica dos músculos masseter e temporais durante o repouso, mastigação e deglutição dos obesos de acordo com sexo e idade não apresentaram diferença estatística significante, observa-se uma maior ativação dos músculos masseter do que os músculos temporais. CONCLUSÕES: pode-se concluir que crianças e adolescentes obesos, de ambos os sexo têm características miofuncionais dentro da normalidade e que há uma maior ativação dos músculos masseteres para a função da mastigação e deglutição do que os músculos temporais.

  4. Microbial degradation of monocyclic and polycyclic aromatic hydrocarbons in case of limited pollutant availability with nitrate as a potential electron acceptor; Der mikrobielle Abbau mono- und polyzyklischer aromatischer Kohlenwasserstoffe bei einer begrenzten Schadstoffverfuegbarkeit mit Nitrat als potentiellem Elektronenakzeptor

    Energy Technology Data Exchange (ETDEWEB)

    Linke, C.

    2001-07-01

    The possibility of using natural degradation processes for long-term remediation of tar oil contaminated sites was investigated. Field studies have shown that microbial decomposition of pollutants does take place in many sites but that it is limited by limited availability of pollutants and oxygen in soil. The investigations focused on the activation of BTEX and PAH degradation in situ by nitrate in the absence or in the presence of oxygen. Tensides should be used in order to enhance the availability of pollutants in water, especially in the case of hardly water-soluble PAH. A large-scale experiment was carried out on tar oil contaminated terrain; it was found that the availability of oxygen and not of PAH is the limiting factor so that adding of surfactants will not improve pollutant degradation. In contrast, the adding of tensides would mean even higher concentrations of oxygen-depleting substances in soil. [German] In der vorliegenden Arbeit wurden im Hinblick auf langfristige Sanierungsstrategien fuer teeroelkontaminierte Standorte Moeglichkeiten der Nutzung natuerlicher Abbauvorgaenge untersucht. Zahlreiche Feldstudien belegen, dass ein mikrobieller Schadstoffabbau an vielen Standorten stattfindet, dieser jedoch sowohl durch eine begrenzte Schadstoffverfuegbarkeit als auch durch den im Untergrund nur begrenzt zur Verfuegung stehenden Sauerstoff limitiert wird. Ziel dieser Arbeit war es abzuklaeren, inwiefern ein BTEX- und PAK-Abbau in situ auch in Abwesenheit von Sauerstoff durch Nitrat allein oder durch Nitrat in Kombination mit Sauerstoff aktiviert werden kann. Um insbesondere fuer die schlecht wasserloeslichen PAK eine ausreichende Schadstoffverfuegbarkeit zu gewaehrleisten, sollten auch Tenside zur Erhoehung der im Wasser vorliegenden Schadstoffmenge eingesetzt werden. Aufbauend auf die Laboruntersuchungen wurde im Rahmen von VEGAS{sup ix} ein Grossversuch zum mikrobiellen PAK-Abbau im Abstrom einer simulierten Teeroelkontamination durchgefuehrt

  5. Efeitos de diferentes graus de sensibilidade a insulina na função endotelial de pacientes obesos Efectos de diferentes grados de sensibilidad a la insulina en la función endotelial de pacientes obesos Effects of different degrees of insulin sensitivity on endothelial function in obese patients

    Directory of Open Access Journals (Sweden)

    Roberto Galvão

    2012-01-01

    Full Text Available FUNDAMENTO: A obesidade derivada da deposição de gordura intra-abdominal tende a aumentar a produção de hormônios e citoquinas, piorando a sensibilidade a insulina e levando a disfunção endotelial. A hiperinsulinemia é considerada um fator de risco independente para doença isquêmica cardíaca e é uma causa de disfunção endotelial em indivíduos saudáveis. OBJETIVO: Avaliar o impacto de diferentes graus de resistência a insulina, medida pelo HOMA-IR (Homeostasis Model Assessment of Insulin Resistance, sobre a função endotelial de obesos, pacientes não diabéticos, sem história prévia de eventos cardiovasculares e diversos componentes da síndrome metabólica. MÉTODOS: Um total de 40 indivíduos obesos foi submetido a medidas antropométricas, pressão arterial de consultório, MAPA e exames laboratoriais, além de avaliação ultrassonográfica não invasiva da função endotelial. Os pacientes foram divididos em três grupos de acordo com o grau de resistência a insulina: pacientes com valores de HOMA-IR entre 0,590 e 1,082 foram incluídos no Grupo 1 (n = 13; entre 1,083 e 1,410 no Grupo 2 (n = 14; e entre 1,610 e 2,510 no Grupo 3 (n = 13. RESULTADOS: Encontramos uma diferença significativa na vasodilatação mediada por fluxo no Grupo 3 em relação ao Grupo 1 (9,2 ± 7,0 vs 18,0 ± 7,5 %, p = 0,006. Houve uma correlação negativa entre a função endotelial e insulina, HOMA-IR e triglicérides. CONCLUSÃO: Nosso estudo sugere que leves alterações nos níveis de resistência a insulina avaliada pelo HOMA-IR podem causar algum impacto sobre a função vasodilatadora do endotélio em indivíduos obesos não complicados com diferentes fatores de risco cardiovascular.FUNDAMENTO: La obesidad derivada del depósito de grasa intraabdominal tiende a aumentar la producción de hormonas y citocinas, empeorando la sensibilidad a la insulina y llevando a disfunción endotelial. La hiperinsulinemia es considerada un factor de

  6. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

    OpenAIRE

    Thiago Bruder Nascimento; Rafaela de Fátima Ferreira Baptista; Priscila Cristina Pereira; Dijon Henrique Salomé de Campos; André Soares Leopoldo; Ana Paula Lima Leopoldo; Silvio A. de Oliveira Júnior; Carlos Roberto Padovani; Antônio Carlos Cicogna; Sandra Cordellini

    2011-01-01

    FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C) e obeso (OB, ratos sob dieta rica em gordura por 30 semanas). Após 30 semanas, foram registrados o peso corporal, índice de adip...

  7. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos

    OpenAIRE

    Priscila de Lima Sanches; Marco Túlio de Mello; Francisco Antonio Helfestein Fonseca; Natália Elias; Aline de Piano; June Carnier; Lian Tock; Lila Missae Oyama; Sergio Tufik; Ana Dâmaso

    2012-01-01

    FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo M...

  8. Associação entre ingestão alimentar compulsiva e índice de massa corporal em adolescentes obesos seguidos numa consulta de obesidade

    OpenAIRE

    Pereira, Carla Maria Ribeiro dos Santos, 1971-

    2012-01-01

    Pouco se sabe acerca da ingestão alimentar compulsiva (IAC) nos adolescentes, entidade que parece ter prevalência especialmente elevada em crianças e adolescentes obesos que procuram tratamento com o objectivo de perder peso, e nos quais, parece estar associada a piores resultados, nomeadamente a maior dificuldade em perder peso. O objectivo deste estudo foi estimar a prevalência de IAC e sua associação com o índice de massa corporal (IMC), nos adolescentes obesos (IMC ≥ P95) no momento d...

  9. Função pulmonar e perda de peso em indivíduos obesos mórbidos submetidos à gastroplastia

    OpenAIRE

    Scipioni, Gabriela

    2011-01-01

    Resumo: O objetivo do estudo foi avaliar a função pulmonar de indivíduos obesos mórbidos submetidos à gastroplastia, relacionando as modificações espirométricas com a perda de peso. A pesquisa caracterizou-se como estudo de caso controle observacional. Foram selecionados por conveniência 25 indivíduos adultos obesos mórbidos, de ambos os sexos, divididos em dois grupos: Cirúrgico (n=15) e Controle (n=10), recrutados na Clínica de Obesidade na cidade de Maringá-PR, provenientes do Sistema Únic...

  10. Limiar de variabilidade da freqüência cardíaca em adolecentes obesos e não-obesos Heart rate variability threshold in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Antônio Fernando Brunetto

    2008-04-01

    Full Text Available A obesidade na adolescência está associada à disfunção simpato-vagal cardíaca em repouso, embora existam poucas informações sobre a resposta autonômica durante o exercício nestes adolescentes. OBJETIVO: Comparar a modulação autonômica durante teste de esforço físico dinâmico incremental em amostras de adolescentes obesos e não-obesos, e analisar a relação entre o limiar de variabilidade da freqüência cardíaca (LiVFC e o limar ventilatório (LV. MÉTODOS: Dez adolescentes obesos e 19 adolescentes não-obesos do sexo masculino com idades entre 13 e 18 anos foram submetidos à teste de esforço físico progressivo máximo em esteira rolante para estudo da variabilidade da freqüência cardíaca (VFC e para identificação do LV. A VFC foi estudada mediante análise do desvio-padrão da variabilidade instantânea batimento-a-batimento (SD1 da Plotagem de Poincaré. O LiVFC foi identificado na intensidade de esforço físico em que o SD1 atingiu valor menor que 3 ms. RESULTADOS: O índice SD1 diminuiu progressivamente em ambos os grupos até aproximadamente 50-60% do VO2pico, sendo que os adolescentes obesos apresentaram valores significativamente menores (pObesity in adolescence is associated with a cardiac sympathetic-parasympathetic dysfunction at rest. However, there is little information about the autonomic response during exercise in these adolescents. OBJECTIVE: To compare the cardiac autonomic modulation during a maximal exercise test in obese and non-obese adolescents and analyze the association between the Heart Rate Variability threshold (HRVT and the Ventilatory threshold (VT. METHODS: Ten obese and 19 non-obese male adolescents with age between 13-18 years were submitted to a maximal progressive treadmill physical exercise test for Heart Rate Variability (HRV study and VT determination. HRV was assessed through the study of Poincaré Plot, by the analysis of the standard deviation of instantaneous beat

  11. Motivação à prática regular de atividades físicas e esportivas: um estudo comparativo entre estudantes com sobrepeso, obesos e eutróficos Motivation of regular physical and sporting activities practice: a comparative study between obeses, overweight, and other students

    Directory of Open Access Journals (Sweden)

    Marcos Alencar Abaide Balbinotti

    2011-09-01

    Full Text Available O principal objetivo do presente estudo é comparar os níveis de motivação à prática regular de atividades físicas de três diferentes grupos de alunos das escolas de ensino fundamental e médio do município de Erechim/RS: Obesos, com sobrepeso, e eutróficos. Para tanto, além das avaliações antropométricas - massa corporal e altura - foi aplicado o Inventário de motivação à prática regular de atividades físicas e esportivas (IMPRAFE-54 ( BALBINOTTI; BARBOSA, 2006 . Os resultados variaram consideravelmente em valores nominais e a principais dimensões motivacionais foram as seguintes: Obesos (saúde; sobrepeso (estética; saúde; prazer; eutróficos (saúde, estética, prazer. Na comparação inter-grupo (obesos; sobrepeso; eutróficos, a dimensão Estética se destacou na diferença entre os grupos de sobrepesos e obesos. Espera-se que esses resultados possam contribuir para a prática pedagógica da educação física escolar.The main intent of the present study is compare the motivation levels of regular physical activities practice of three differents scholars groups from elementary and middle schools of Erechim/RS municipal district: Obeses, overweight, and Eutrophic. Then, besides the anthropometry evaluations - corporal mass and height - was applied the "Inventário de motivação à prática regular de atividades físicas e esportivas" (IMPRAFE-54 ( BALBINOTTI; BARBOSA, 2006 . The results varied considerably in nominal values and the main motivation dimensions were as follows: Obeses (health; overweight (esthetics; health; joy; Eutrophic (health; esthetics; joy. In comparing inter-group (obese, overweight, Eutrophic, the Aesthetic dimension stood out in the difference between the groups of overweight and obese. Hope these results might contribute for the pedagogy practice in scholar physical education.

  12. Resonant mono Higgs at the LHC

    CERN Document Server

    Basso, Lorenzo

    2015-01-01

    In recent years, the production of a SM particle with large missing transverse momentum, dubbed mono-X searches, have gained increasing attention. After the discovery of the Higgs boson in 2012, the run-II of the LHC will now scrutinise its properties, looking for BSM physics. In particular, one could search for mono-Higgs signals, that are typically studied in models addressing dark matter. However, this signal can appear also in models addressing the neutrino masses, if additional heavier neutrinos with masses at the electroweak scale are present. The latter will couple to the SM neutrinos and the Higgs boson, yielding a type of mono-Higgs signal not considered for dark matter: the resonant production of a Higgs boson and missing energy. In this paper, we address the LHC exclusion power of the latter with dedicated detector simulations, and reinterpret it in a benchmark model for neutrino mass generation.

  13. Group dialectical behavior therapy adapted for obese emotional eaters: a pilot study Terapia dialéctico-compartimental grupal adaptada para el tratamiento "comedores emocionales" obesos: un estudio piloto

    Directory of Open Access Journals (Sweden)

    M. A. Roosen

    2012-08-01

    Full Text Available Dialectical Behavior Therapy (DBT has been shown to effectively target binge eating disorder (BED. This study pilots the effectiveness of group DBT for obese "emotional eaters" to reduce eating psychopathology and achieve weight maintenance. Thirty-five obese male and female emotional eaters receiving 20 group psychotherapy sessions of DBT adapted for emotional eating were assessed at end-of-treatment and 6 month follow-up for reductions in eating psychopathology and weight maintenance. DBT resulted in significant reductions in emotional eating and other markers of eating psychopathology at the end-of-treatment that were maintained at follow-up. The drop-out rate was very low, with only 1 participant dropping from treatment. Thirty-three (94% of the sample provided data at every assessment point. Of these, 80% achieved either weight reduction or weight maintenance after treatment and throughout the follow-up period. The effect size for weight reduction was small. This pilot study demonstrates group DBT targeting emotional eating in the obese to be a highly acceptable and effective intervention for reducing eating related psychopathology at both at end-of-treatment and during follow-up. The ability of DBT to limit the upward trajectory of weight gain in obese patients with high degrees of emotional eating suggests that DBT may also help limit the increase or even prevent onset of obesity related morbidity in these patients.La Terapia Dialéctico-Conductual (TDC es una terapia eficaz para el tratamiento del trastorno por atracón (TA. Este estudio piloto pretende estudiar la eficacia de la TDC grupal para la reducción de psicopatologia alimentaria y el logro el mantenimiento del peso, para obesos "comedores emocionales". Treinta y cinco obesos "comedores emocionales" de ambos sexos fueron evaluados al final del tratamiento y en seguimiento a los seis meses en psicopatología alimentaria y reducción de peso tras recibir 20 sesiones de TDC en

  14. Características socioeconómicas, familiares y ambientales en niños obesos de la Parroquia Antimano - Caracas

    Directory of Open Access Journals (Sweden)

    William José González Cabriles

    2009-01-01

    Full Text Available El objetivo del Artículo es caracterizar a las familias de niños obesos con métodos cuantitativo y cualitativo a fin de facilitar la intervención. El estudio fue transversal descriptivo - retrospectivo de familias de niños obesos atendidos en CANIA (1997 - 2000, Antímano - Caracas. Se estudiaron los datos socioeconómicos de 295 familias, utilizándose la distribución de frecuencia y la media para analizarlos mediante el programa SPSS 9.0 y se evaluó la dinámica familiar en dos casos, aplicándose la entrevista en profundidad en el hogar. La mayoría de las familias con niños obesos son pobres (Línea de pobreza y Graffar modificado, presentan diferente tipología y composición; sus integrantes se relacionan más con el paciente obeso; generalmente las conforman padres obreros con nueve años de escolaridad; destinan 70% del presupuesto a la alimentación y ésta última es influenciada por el jefe de familia; su comportamiento alimentario reflejó aspectos culturales y económicos; conocen las causas e implicaciones de la obesidad pero no la aceptan como problema; priorizan en salud, solo cuando aparecen enfermedades crónicas no trasmisibles; consideran a los factores externos limitantes para el cumplimiento del tratamiento nutricional. Se concluye que el conocimiento de las características socioeconómicas, familiares y ambientales del niño obeso, potencia la atención social e integral.

  15. Gravity and magnetic investigations of the Mono-Inyo Volcanic Chain, Mono Basin, California

    Science.gov (United States)

    Pera, A. A.; Ponce, D. A.; McPhee, D. K.; Battaglia, M.

    2010-12-01

    The Mono Inyo volcanic chain is a 25-km long, north-south trending series of domes and craters extending southward from Mono Lake and into the west moat of Long Valley Caldera. Based on the Holocene history of eruptions in the area, the chain appears to hold the greatest potential for renewed magmatic activity (Hildreth, 2004). To better characterize the geometry and structure of Mono Basin for future dynamic modeling of the Mono Inyo volcanic chain a new gravity and magnetic survey was conducted. We collected gravity data at over 320 stations in and around the northern and central region of the Mono-Inyo volcanic chain and around Mono Lake in the summer of 2010. Regional gravity data was collected at one-mile spacing and data collected on profile lines was collected at quarter-mile intervals. We collected magnetic data on major roads along several transects across Mono Basin that include one coincident with a seismic refraction line (Hill and others, 1985). Rock samples were collected for analysis of density and magnetic susceptibility. The new gravity and magnetic data will be compiled with pre-existing data from studies dating back to the 1960’s (Pakiser and others, 1960, 1976; Christensen, 1969) to produce new isostatic gravity and magnetic anomaly maps. Preliminary isostatic gravity and magnetic maps from pre-existing data show the presence of gravity and magnetic lows in Mono Lake and Long Valley Caldera where low density volcanic sediments are prevalent; gravity highs were observed to the east and west of Mono Lake and to the east of Long Valley Caldera. A region with a high magnetic anomaly lies to the east of the volcanic chain. Two-dimensional forward modeling of potential field data along profiles that extend across Mono Basin will constrain the density and magnetization distribution, stratification and structural geology of the Mono-Inyo volcanic chain. These efforts are critical to improve dynamic modeling of Sierran range-front faulting and dike

  16. Review of the recording and age of the Mono Lake Excursion

    Science.gov (United States)

    Coe, R.; Liddicoat, J.

    2009-04-01

    Among the brief departures from gradual, long-term behaviour of the palaeomagnetic field in the Brunhes Normal Chron that reached opposite polarity or have a Virtual Geomagnetic Pole deep in the southern hemisphere, the first to be reported is the Laschamp Excursion (LE) in volcanic rocks in the Massif Central in France (Bonhommet and Zahringer, 1969). They originally believed it occurred between about 9,000 to 20,000 years before present, but it is now assigned an age of about 40,000 years B.P. (Guillou et al., 2004). Denham and Cox (1971) unsuccessfully sought the LE in exposed lake sediments that seemed to span that interval in the Mono Basin in the western Great Basin of the U.S., but instead encountered anomalous field behaviour that is called the Mono Lake Excursion (MLE)(Liddicoat and Coe, 1979). As a tribute to Norbert Bonhommet, who assisted us in our initial field work in the Mono Basin and shared a long-standing interest in the LE and MLE, we will review the palaeomagnetic behaviour and age of the MLE in the Mono Basin and elsewhere, for which there are nearly 20 reports of its occurrence globally, and evaluate the recent suggestion that the excursion at Mono Lake and the LE are the same.

  17. Mono versus Stereo: Bilingualism's Double Face.

    Science.gov (United States)

    Grutman, Rainier

    1993-01-01

    Offers an application of Mikhail Bakhtin's heteroglossia model, describing literature from a diversified point of view. Analyzes two examples to show nevertheless that Bakhtin unilaterally celebrates "stereo" qualities of language blending, and leaves no room for "mono" texts, which use polyglot devices as borders much more than as bridges between…

  18. O efeito em curto prazo do bypass gástrico sobre pacientes obesos diabéticos

    Directory of Open Access Journals (Sweden)

    Aluisio Stoll

    2013-02-01

    Full Text Available OBJETIVO: estudar o efeito do bypass gástrico sobre a glicemia e o uso de medicação antidiabética em pacientes obesos portadores de diabetes. MÉTODOS: estudo de coorte retrospectivo com 44 pacientes obesos portadores de DM2, provenientes de 469 pacientes submetidos ao bypass gástrico no período de dezembro de 2001 a março de 2009. Os desfechos primários avaliados foram: glicemia em jejum e a necessidade de medicação antidiabética. RESULTADOS: a população foi composta de dez (22,7% homens e 34 (77,3% mulheres, com média de idade de 45,3 (±8,23 anos e índice de massa corporal de 40,9 (±5,03 kg/m². O tempo médio de evolução do DM2 foi 63,6 (±60,9 meses. Dos 40 pacientes que utilizavam medicação para controle do DM2, 20 (50% tiveram sua medicação suspensa na alta hospitalar e 13 (32,5% até nove meses depois. Em uma paciente não foi possível avaliar o uso de medicação, sendo essa a única exclusão. A insulina foi suspensa nos dez (100% pacientes que a utilizavam, sendo seis (60% na alta hospitalar. Houve redução (P<0,05 da glicemia em jejum, em todo o período estudado, em comparação com o valor pré-operatório, e foram atingidos valores inferiores a 100mg/dl no período de sete a nove meses. CONCLUSÃO: Pacientes obesos portadores de DM2, submetidos ao bypass gástrico, apresentaram melhora do controle glicêmico e redução do uso de hipoglicemiantes em curto prazo.

  19. Aptidão cardiorrespiratória, perfil lipídico e metabólico em adolescentes obesos e não-obesos Cardiorespiratory fitness, lipid and metabolic profile in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Neiva Leite

    2009-09-01

    Full Text Available O objetivo deste estudo foi investigar a relação entre o consumo máximo de oxigênio, perfil lipídico e metabólico em meninas e meninos obesos e não-obesos. Estudo transversal, descritivo e correlacional. A amostra foi composta por 91 obesos e 30 não-obesos, dos 10 aos 16 anos. Avaliou-se o índice de massa corporal (IMC e a circunferência abdominal (CA. A aptidão cardiorrespiratória foi avaliada de forma direta através da análise do consumo máximo de oxigênio (O2max. Determinaram-se níveis de colesterol total (CT, lipoproteína de alta densidade (HDL-C, lipoproteína de baixa densidade (LDL-C, triglicérides (TG, glicemia e insulinemia após 12 horas de jejum. Analisaram-se os dados pelo teste "t" de student e correlação parcial controlada pela idade, com um nível de significância de pO2max com o IMC (r = -0,540; p O2max com a CT, a fração LDL-C e a glicemia.O menor VO2max correlacionou com maiores adiposidade, TG e insulinemia, bem como redução de HDL. O O2max não correlacionou com o CT, LDL-C e glicemia, sugerindo a importância do controle genético sobre estas variáveis e um menor tempo de influência do sedentarismo na população infanto-juvenil.The aim this study was investigates the relationship between maximum oxygen consumption, lipid and metabolic profile in obese and non-obese girls and boys. Transversal, descriptive and correlational study. 91 obese and 30 non-obese subjects participated, with 10 to 16 years. There were well overall adiposity by body mass index (BMI, and central adiposity by waist circumference (WC. The cardiorespiratory fitness was assessed by a direct analysis of maximum oxygen consumption (O2max. Are determined levels of total cholesterol (TC, high density lipoprotein (HDL-C, low density lipoprotein (LDL-C, triglycerides (TG, glucose and insulin after 12 hours of fasting. We analyzed the data by "t" student`s test and partial correlation controlled for age, with a significance level of p

  20. Risco nutricional e complicações em obesos hospitalizados submetidos à cirurgia Nutritional risk and complications in hospitalized obese patient submitted to surgery

    Directory of Open Access Journals (Sweden)

    Mariana Raslan

    2007-12-01

    Full Text Available RACIONAL: Risco nutricional mede o potencial de morbimortalidade associado ao estado nutricional. A obesidade é um distúrbio nutricional cada vez mais presente em hospitais gerais e pode estar acompanhada de alteração nutricional com conseqüências prejudiciais à evolução clínica do doente, além de ser fator associado a complicações pós-operatórias e morte. OBJETIVO: Identificar o risco nutricional através da ferramenta de triagem nutricional Malnutrition Universal Screening Tool e verificar o desfecho de complicações pós-operatórias, buscando associação entre risco nutricional e obesidade. MÉTODOS: Avaliaram-se 433 pacientes adultos hospitalizados em enfermarias cirúrgicas variadas, Na admissão hospitalar mediu-se peso e altura corpóreos. Aplicou-se a triagem nutricional após definição da obesidade pelo Índice de Massa Corpórea (Kg/m2 e classificação em grau I (30-34,99 Kg/m2; grau II (35-39,99 Kg/m2; grau III (±40,00 Kg/m². Os pacientes foram seguidos até a alta hospitalar ou óbito para acompanhar sua evolução clínica. RESULTADOS: Dentre os pacientes avaliados, 17,1% foram obesos. O risco nutricional nos pacientes obesos foi 23%. Ocorreram complicações em pacientes das enfermarias cirúrgicas de esôfago, vias biliares, vascular, cabeça e pescoço. As complicações apresentadas incluíram infecções pulmonares, de parede abdominal e urinária, fístulas gastrintestinal, biliar e pancreática, insuficiência respiratória, atelectasia lobar, e sangramento pós-operatório. CONCLUSÕES: Obesos hospitalizados podem apresentam risco nutricional sendo a obesidade grau I a mais freqüente entre eles em hospital geral. Houve associação positiva entre risco nutricional e freqüência de complicações justificando triagem nutricional na admissão hospitalar como rotina, incluindo pacientes com sobrepeso e obesidade.BACKGROUND: Nutritional risk measures the morbid-mortality potential associated to

  1. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial Alteraciones vasculares en ratones obesos por dieta rica en grasa: papel de la vía L-arginina/NO endotelial Vascular alterations in high-fat diet-obese rats: role of Endothelial L-arginine/NO Pathway

    OpenAIRE

    Thiago Bruder Nascimento; Rafaela de Fátima Ferreira Baptista; Priscila Cristina Pereira; Dijon Henrique Salomé de Campos; André Soares Leopoldo; Ana Paula Lima Leopoldo; Silvio A. de Oliveira Júnior; Carlos Roberto Padovani; Antônio Carlos Cicogna; Sandra Cordellini

    2011-01-01

    FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C) e obeso (OB, ratos sob dieta rica em gordura por 30 semanas). Após 30 semanas, foram registrados o peso corporal, índice de adip...

  2. Search for Exotic mono-jet and mono-photon signatures with the ATLAS detector

    Directory of Open Access Journals (Sweden)

    Rezvani Reyhaneh

    2013-05-01

    Full Text Available Mono-jet and mono-photon signatures are final states in a variety of scenarios beyond the Standard Model, such as the Large Extra Dimension models, gauge-mediated SUSY breaking scenarios, and models with pair production of Weakly Interacting Massive Particles considered as dark matter candidates. The produced exotic particles do not interact with the detector, resulting in missing transverse energy. The results of searches, performed in the ATLAS experiment at the LHC, for new physics in final states with an energetic jet or photon and large missing transverse energy are presented. The mono-jet search is performed using both 4.6 fb−1 of 7 TeV and 10.5 fb−1 of 8 TeV data, while the mono-photon results correspond to 4.6 fb−1 of 7 TeV data.

  3. Possible Recording of the Hilina Pali Excursion in the Mono Basin, California

    Science.gov (United States)

    Coe, R.; Liddicoat, J.

    2012-04-01

    Inclination of about negative 40˚ in basalt from Kilauea volcano, Hawaii (Teanby et al., 2002), that is assigned an age of about 18,000 radiocarbon years (uncorrected)(Coe et al., 1978, after Rubin and Berthold, 1961) and an excursion in northeastern China at Changbaishan Volcano of similar age from Ar40/Ar39 dates (Singer et al., 2011) that was interpreted to be the Blake Subchron (Zhu et al., 2000) using K/Ar (Liu, 1987) and Ar40/39 dates (Lin, 1999), might be recorded as shallow positive inclination in lacustrine siltstone in the bank of Wilson Creek in the Mono Basin, CA. The siltstone was deposited in Pleistocene Lake Russell, of which Mono Lake is the remnant, and was exposed when Wilson Creek was incised as the shoreline of Mono Lake receded (Lajoie, 1968). Basaltic and rhyolitic volcanic ash layers exposed in the bank of the creek are stratigraphic markers that have been important for studies of the Mono Lake Excursion (Denham and Cox, 1971; Liddicoat and Coe, 1979; Liddicoat, 1992; Coe and Liddicoat, 1994) and Pleistocene climate in the U.S. Great Basin (Zimmerman et al., 2006). Those ash layers likewise are useful for locating paleomagnetic directions along strike that might be the negative inclination in Hawaii named the Hilina Pali Excursion (Teanby et al., 2002). The portion of the lacustine section exposed along Wilson Creek that is of interest records waveform Delta in Lund et al. (1988) in Subunit E of Lajoie (1993) that is bracketed by ash layers 12 and 13; in Lajoie (1968), those ash layers are numbered 8 and 7, respectively. About midway in Subunit E, which has a thickness of 1.1 m, the inclination is about 15˚ in four back-to-back horizons that span 8 cm. The subsamples, each 2 cm thick, were treated by either alternating field or thermal demagnetization. The Virtual Geomagnetic Pole (VGP) for the horizon with the shallowest inclination (14.9˚) is 53.8˚ N, 22.7˚ E (n = 6, Alpha-95 = 2.3˚), and the VGPs within waveform Delta when followed

  4. Discrepâncias na imagem corporal e na dieta de obesos Self-discrepancy in body image and diet

    OpenAIRE

    Patrícia Kanno; Misael Rabelo; Gislane Ferreira Melo; Adriana Giavoni

    2008-01-01

    OBJETIVO: Este estudo avaliou a discrepância entre a imagem real e a imagem ideal de indivíduos obesos e procurou relacionar possíveis alterações no comportamento alimentar na busca desse corpo ideal. MÉTODOS: A amostra foi composta por 25 sujeitos, sendo 76% do sexo feminino e idade média de 39,24 (desviopadrão=5,01) anos. Dois instrumentos foram utilizados: a Escala de Aparência Física, cuja análise fatorial extraiu um único fator "Aparência Física" com precisão de α=0,74 para mulheres...

  5. Células progenitoras endoteliais circulantes em crianças e adolescentes obesos

    Directory of Open Access Journals (Sweden)

    António Pires

    2015-12-01

    ão elevados em crianças e adolescentes obesos com comprovação de ativação endotelial. Isso sugere que, na infância, os mecanismos de reparação endotelial estão presentes no contexto da ativação endotelial.

  6. MRI in hypertrophic mono- and polyneuropathies

    International Nuclear Information System (INIS)

    Different conditions that may lead to enlarged nerves or nerve roots include hereditary motor and sensory neuropathy (HMSN), neurofibromatosis (NF) type 1, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and intraneural perineurioma. Differential diagnosis of hypertrophic mono- and polyradiculopathies remains challenging but is important because of different treatments and prognosis. Magnetic resonance imaging (MRI) can identify the hypertrophic nerve segments and guide a fascicular biopsy. A fascicular biopsy will often be necessary for precise diagnosis

  7. Mono Lake Excursion as a Chronologic Marker in the U.S. Great Basin

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.; Knott, J. R.

    2008-05-01

    Nevada, Utah, and California east of the Sierra Nevada are in the Great Basin physiographic province of western North America. During periods of the Pleistocene, Lake Bonneville and Lake Lahontan covered valleys in Utah and Nevada, respectively, and other lakes such as Lake Russell in east-central California did likewise (Feth, 1964). Now dry except for its remnant, Mono Lake, Lake Russell provides an opportunity to study behavior of Earth's past magnetic field in lacustrine sediments that are exposed in natural outcrops. The sediments record at least 30,000 years of paleomagnetic secular variation (Liddicoat, 1976; Zimmerman et al., 2006) and have been of particular interest since the discovery of the Mono Lake Excursion (MLE) by Denham and Cox (1971) because the field behavior can be documented at numerous sites around Mono Lake (Liddicoat and Coe, 1979, Liddicoat, 1992; Coe and Liddicoat, 1994) and on Paoha Island in the lake. Moreover, there have been recent attempts to date the excursion (Kent et al., 2002, Benson et al., 2003) more accurately and use the age and relative field intensity in paleoclimate research (Zimmerman et al., 2006). It has been proposed that the excursion in the Mono Basin might be older than originally believed (Denham and Cox, 1971; Liddicoat and Coe, 1979) and instead be the Laschamp Excursion (LE), ~ 40,000 yrs B.P. (Guillou et al., 2004), on the basis of 14C and 40Ar/39Ar dates (Kent et al., 2002) and the relative paleointensity record (Zimmerman et al., 2006) for the excursion in the Mono Basin. On the contrary, we favor a younger age for the excursion, ~ 32,000 yrs B.P., using the relative paleointensity at the Mono and Lahontan basins and 14C dates from the Lahontan Basin (Benson et al., 2003). The age of ~ 32,000 yrs B.P. is in accord with the age (32,000-34,000 yrs B.P.) reported by Channell (2006) for the MLE at Ocean Drilling Program (ODP) Site 919 in the Irminger Basin in the North Atlantic Ocean, which contains as well an

  8. Avaliação da composição corporal em adolescentes obesos: o uso de dois diferentes métodos Evaluación de la composición corporal en adolescentes obesos: uso de dos metodos diferentes Body composition evaluation in obese adolescents: the use of two different methods

    Directory of Open Access Journals (Sweden)

    Marco Túlio de Mello

    2005-10-01

    Full Text Available A pletismografia é um método rápido e fácil para determinação da composição corporal que utiliza a relação inversa entre pressão e volume. O objetivo do presente estudo foi o de comparar os valores obtidos com o método pletismografia com os valores observados com o DEXA em uma população de adolescentes obesos. Participaram da amostra 88 adolescentes pós-púberes de ambos os sexos, com idades entre 15 e 19 anos (17,01 ± 1,6 ingressantes de um programa de atividade física multidisciplinar. Os voluntários foram submetidos a uma avaliação da composição corporal em dias distintos dentro da mesma semana, pelo método de pletismografia e outra avaliação pelo método DEXA. Quando os métodos foram comparados, não se observaram diferenças significativas entre eles; além disso, foram observadas correlações significativas entre os parâmetros comuns dos dois métodos (massa magra, massa gorda (kg e massa gorda (%, r = 0,88 p La pletismografía es un método rápido y fácil para la determinación de la composición corporal que utiliza la relación inversa entre la presión y el volumen. El objetivo del presente estudio fué el de comparar los valores obtenidos con el metodo pletismografia con los valores observados con el DEXA en una población de adolescentes obesos. Participaron de la muestra 80 adolescentes post púberes de ambos sexos, con edades entre los 15 y los 19 años (17,01±1,6 iniciantes en un programa de actividad física multidisciplinar. Los voluntarios fueron sometidos a una evaluación de la composición corporal en días distintos dentro de la misma semana, por el método de pletismografia y otra evaluación por el método DEXA. Cuando se compararon los métodos, no fueron observadas diferencias significativas entre ellos, además de ello, fueron observadas correlaciones entre los parámetros comunes a los dos métodos (masa magra, masa grasa (kg y masa gorda (%, r = 0,88 p Plethysmography is an easy and

  9. Factores relacionados con la pérdida de peso en una cohorte de pacientes obesos sometidos a bypass gástrico

    Directory of Open Access Journals (Sweden)

    Adriana Giraldo Villa

    2013-06-01

    Full Text Available Introducción: La obesidad es catalogada como la epidemia del siglo XXI. El tratamiento médico multidisciplinario no ha sido suficiente y las técnicas quirúrgicas son empleadas con mayor frecuencia. El bypass gástrico es considerado el gold standard de la cirugía bariátrica, sin embargo, algunos pacientes reportan bajas tasas de pérdida de peso, lo que hace pensar en otros factores condicionantes. Objetivo: Establecer los factores asociados con la pérdida de peso, en una cohorte de pacientes obesos sometidos a bypass gástrico. Métodos: Estudio analítico retrospectivo. La variable respuesta fue la pérdida de peso, expresada en porcentaje del exceso de índice de masa corporal perdido (PEIMCP. Se realizó un modelo de regresión lineal de efectos mixtos y un modelo de riesgos proporcionales de COX. Resultados: Se estudiaron 166 pacientes entre 19 y 69 años, la mayoría mujeres (74,7%. Los hombres presentaron un índice de masa corporal (IMC inicial promedio de 46,9 ± 6,8 kg/m² y las mujeres de 46,3 ± 7,7 kg/m². El análisis multivariado mostró que por cada 10,0 kg/m² de mas al momento de la cirugía, disminuyó el PEIMCP en un 9,8% y un inadecuado consumo calórico diario disminuyó en un 4,0% el PEIMCP. Por cada 10,0 kg/m² de IMC inicial, hubo una disminución del 57,8% en la probabilidad de lograr una pérdida de peso del 50%. Conclusiones: Los pacientes con menor exceso de peso según su índice IMC responden mejor a la cirugía bariátrica en términos del PEIMCP.

  10. Características miofuncionais de obesos respiradores orais e nasais Myofunctional characteristics of obese mouth and nose breathers

    Directory of Open Access Journals (Sweden)

    Denise Bolzan Berlese

    2012-06-01

    Full Text Available OBJETIVO: Investigar as características miofuncionais de obesos respiradores orais e nasais. MÉTODOS: Foram selecionados por conveniência 24 obesos, com idades entre 8 e 15 anos, pertencentes ao Grupo de Obesidade do Ambulatório de Pediatria de um Hospital Universitário. As características miofuncionais foram avaliadas por meio do protocolo de Avaliação Miofuncional Orofacial com Escalas (AMIOFE. RESULTADOS: Foi observada respiração oral em 62,5%, e respiração nasal em 37,5% da população estudada. No grupo de respiradores orais, 40% apresentaram oclusão com tensão dos lábios e 80% palato com largura diminuída, enquanto que quase todos os respiradores nasais tinham palato e lábios com postura normal. Interposição da língua nos arcos dentários ocorreu em 47% dos respiradores orais e em nenhum dos respiradores nasais. Os respiradores orais mostraram tendência em não repetir a deglutição de um mesmo bolo alimentar. A aparência da face, condição postural da mandíbula, bochechas e função de mastigação foram semelhantes nos dois grupos. CONCLUSÃO: A respiração oral em crianças e adolescentes obesos foi acompanhada de alterações miofuncionais do sistema estomatognático, representadas por diminuição da largura do palato, interposição da língua aos arcos dentários, oclusão dos lábios com tensão e alteração da deglutição.PURPOSE: To investigate the myofunctional characteristics of nasal and oral breathing in obese individuals. METHODS: Participants were 24 obese individuals with ages between 8 and 15 years, who participated in the Obesity Group of the Ambulatory of Pediatrics of an University Hospital, and were selected by convenience. The myofunctional characteristics were assessed using the Orofacial Myofunctional Assessment with Scales (Avaliação Miofuncional Orofacial com Escalas - AMIOFE protocol. RESULTS: Oral breathing was present in 62.5%, and nasal breathing in 37.5% of the population

  11. On mono-W signatures in spin-1 simplified models

    Directory of Open Access Journals (Sweden)

    Ulrich Haisch

    2016-09-01

    Full Text Available The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artifact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  12. On mono-W signatures in spin-1 simplified models

    Science.gov (United States)

    Haisch, Ulrich; Kahlhoefer, Felix; Tait, Tim M. P.

    2016-09-01

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artifact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  13. On Mono-W Signatures in Spin-1 Simplified Models

    CERN Document Server

    Haisch, Ulrich; Tait, Tim M P

    2016-01-01

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artefact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  14. On mono-W signatures in spin-1 simplified models

    Energy Technology Data Exchange (ETDEWEB)

    Haisch, Ulrich [Oxford Univ. (United Kingdom). Rudolf Peierls Centre for Theoretical Physics; CERN, Geneva (Switzerland). Theory Div.; Kahlhoefer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Tait, Tim M.P. [California Univ., Irvine, CA (United States). Dept. of Physics and Astronomy

    2016-03-15

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artefact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  15. Expresión génica en pacientes obesos con enfermedad hepática por depósito de grasa Gene expression in obese patients with non-alcoholic steatohepatitis

    Directory of Open Access Journals (Sweden)

    A. Cayón

    2008-04-01

    Full Text Available La fisiopatología de la enfermedad hepática por depósito de grasa sólo se conoce de forma parcial. En este trabajo hemos analizado la expresión génica intrahepática de citoquinas, quimioquinas, receptores celulares, factores de crecimiento, transductores de señales intracelulares y proteínas de comunicación extracelular en el tejido hepático de sujetos obesos con y sin esteatohepatitis no alcohólica, en un intento de determinar un perfil de expresión génica asociado a las formas severas de la esteatohepatitis no alcohólica (EHNA. Se analizó un grupo de 38 pacientes obesos con un IMC > 35, que fueron sometidos a cirugía bariátrica. La expresión génica intrahepática se determinó en el tejido hepático dividiendo a los pacientes en tres grupos: a pacientes obesos sin datos histológicos sugestivos de EHNA (n = 12; b pacientes con EHNA sin fibrosis (n = 13; y c pacientes con EHNA y fibrosis (n = 13. Se consideró que existía una sobreexpresión génica cuando la diferencia en la expresión era, al menos, de dos veces con respecto al grupo control. Los resultados se confirmaron mediante PCR en tiempo real. Se detectó una expresión diferencial de 14 genes (10 sobreexpresados y 4 infraexpresados. Los genes sobreexpresados incluyeron prohibitina, TNF, TNF RI (p55, MCSF, R2-TRAIL, TGF-b1, CTGF, FGF, VEGF, BIGH3 y ObRb. La expresión de los genes insulin growth factor-1, insulin growth factor-2, interleuquina-2 y tyrosine-receptor fue menor que en el grupo control. En conclusión: 1. Los pacientes obesos con EHNA sin fibrosis muestran una sobreexpresión de genes proinflamatorios y proapoptóticos. En los pacientes con EHNA y fibrosis, se observa, además, una sobreexpresión de genes profibrogénicos, incluyendo el gen del receptor de la leptina. 2. La expresión de prohibitiva en los pacientes con EHNA, tanto con fibrosis como sin fibrosis, fue superior que en los controles, lo que sugiere una disfunción mitocondrial en los

  16. Qualidade de sono de trabalhadores obesos de um hospital universitário: acupuntura como terapia complementar

    Directory of Open Access Journals (Sweden)

    Mariana Lourenço Haddad

    2012-02-01

    Full Text Available O objetivo do estudo foi verificar o efeito da acupuntura na qualidade de sono de trabalhadores obesos em um hospital universitário. Os dados foram coletados no período de julho a outubro de 2009, junto a 37 funcionários, submetidos a oito aplicações semanais de acupuntura. O Índice de Qualidade de Sono de Pittsburgh foi utilizado para identificar a qualidade de sono dos sujeitos antes e após a intervenção. Os resultados mostram que antes da intervenção cinco (13,5% pessoas apresentaram boa qualidade de sono e, ao final da intervenção, 14 (37,8% relataram este quadro. A diferença obtida na comparação das médias dos escores obtidos antes e após a acupuntura foi significativa (p=0,0001. Concluiu-se que a acupuntura produziu um efeito positivo sobre a qualidade do sono na amostra estudada, apresentando-se como uma técnica adjuvante no tratamento dos distúrbios do sono e consequentemente na melhoria da qualidade de vida desta população.

  17. Tornar-se obeso na adolescência pode trazer consequências à saúde mental?

    Directory of Open Access Journals (Sweden)

    Maria Cecília Formoso Assunção

    2013-09-01

    Full Text Available O estudo avaliou a associação entre trajetória de obesidade e dificuldades emocionais e comportamentais em adolescentes. Foram estudados 4.325 jovens, aos 11 e 15 anos de idade, pertencentes à coorte de nascimentos de 1993 de Pelo-tas, Rio Grande do Sul, Brasil. Informações sobre índice de massa corporal (IMC, avaliação materna da saúde emocional e comportamental do adolescente (Strengths and Difficulties Questionnaire - SDQ e características sociodemográficas e comportamentais foram utilizadas. As análises, estratificadas por sexo, foram conduzidas por meio de regressão linear simples e múltipla. A trajetória de obesidade mostrou associação com o escore total do SDQ, nas análises ajustadas, apenas entre os meninos. Entre esses, tornar-se obeso no período esteve relacionado com maior escore na subescala de problemas de relacionamento com os colegas. Diante do conhecimento atual sobre as implicações futuras da obesidade na saúde mental e em se tratando de adolescentes, sugere-se que estudos que avaliem as diferenças de gênero na adolescência possam contribuir para o entendimento da associação encontrada.

  18. Finite Element Analysis Of Structural And Magmatic Interactions At Mono Basin (California)

    Science.gov (United States)

    La Marra, D.; Manconi, A.; Battaglia, M.

    2010-12-01

    Mono Basin is a northward trending graben situated east of the Sierra Nevada and west of Cowtrack Mountains, extending from the northern edge of Long Valley Caldera towards the Bodie Hills. From a hydrographic perspective, the Mono Basin is defined by all streams that drain into Mono Lake. The Mono-Inyo Craters forms a prominent 25-km-long volcanic complex from the NW corner of Long Valley caldera to the southern edge of Mono Lake. The late Quaternary Hartley Springs fault occurs along the Sierran range front between June Lake and the northern border of Long Valley Caldera. Recently it has been proposed that the manifestation of the volcanic and of the tectonic activity in this area is likely interrelated. According to Bursik et al (2003), stratigraphic data suggest that during the North Mono-Inyo eruption sequence of ~1350 A.D., a series of strong earthquakes occurred across the end of the North Mono explosive phase and the beginning of the Inyo explosive phase. Moreover, geological and geomorphic features of the Hartley Springs fault are consistent with rupture of the fault during the eruption sequence. We use the Finite Element Method (FEM) to simulate a three-dimensional model and investigate the feedback mechanism between dike intrusion and slip along the Hartley Springs fault. We first validate our numerical model against the Okada (1985) analytical solution for a homogeneous and elastic flat half-space. Subsequently, we evaluate the distribution of local stress changes to study the influence of the Inyo Dike intrusion in ~1350 A.D. on Hartley Springs fault, and how the fault slip may encourage the propagation of dikes towards the surface. To this end, we considered the standard Coulomb stress change as failure criterion. Finally, we analyze the effects of the topography and of vertical and lateral heterogeneities of the crust on the distribution of local and regional stress changes. In this presentation, we highlight the preliminary results of our analysis

  19. Respostas fisiológicas ao exercício agudo em ratos obesos tratados com metformina Physiological responses to intense exercise in obese rats treated with metformin

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    Gustavo Gomes de Araujo

    2007-12-01

    Full Text Available O objetivo do presente estudo foi investigar as respostas fisiológicas ao exercício agudo em ratos Wistar obesos, tratados com metformina. Os animais receberam injeção subcutânea de glutamato monossódico (4mg/g peso corporal, para indução da obesidade. Os animais foram divididos em 4 grupos, conforme o tratamento recebido: obesos controles (OC; obesos metformina (OM; obesos controles exercitados (OCE e obesos metformina exercitados (OME. Foram analisados, antes e após uma sessão de exercício agudo: glicose sérica (mg/dL, triglicerídeos (g/100g, colesterol total (mg/dL e hematócrito (%. Os valores de glicose sérica e colesterol total foram reduzidos significativamente no grupo controle exercitado (OCE - 68,4 ± 14,7 e 70,8 ± 18,3 em comparação ao grupo controle sedentário (OC - 83,6 ± 12,8 e 91,3 ± 9,6. A administração de metformina isoladamente diminuiu a concentração de glicose de 83,6 ± 12,8 (OC para 70,8 ± 5,9 (OM. Por outro lado, a associação de metformina com exercício aumentou a disponibilidade de triacilgliceróis livres após a atividade (OM - 166,6 ± 11,3, OME - 184,0 ± 4,3. Em conclusão o programa de intervenção utilizado (exercício físico agudo mostrou-se eficiente na homeostasia glicêmica, bem como, nos níveis circulantes de lipídios em ratos obesos tratados com metformina.The purpose of the present study was to investigate the physiological responses to intense exercise in obese Wistar rats treated with metformin. To induce obesity, all animals were infused with monosodic glutamate (4 mg/g of body weight via subcutaneous injection. The rats were divided in 4 groups according to the received treatment: obese control (OC; obese metformin ( OM; obese control exercise (OCE and obese metformin exercise (OME. Before and after one session of intense exercise the following parameters were measured: serum glucose (mg/dl, triglycerides (g/100g, total cholesterol (mg/dl and haematocrit (%. The values of

  20. Adiposidade corporal e hipertensão arterial em crianças e adolescentes obesos - doi:10.5020/18061230.2009.p88

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    Joel Saraiva Ferreira

    2012-01-01

    Full Text Available Objetivo: Investigar a relação entre a hipertensão arterial e adiposidade corporal em crianças e adolescentes obesos. Métodos: Estudo transversal no qual 129 crianças e adolescentes obesos de ambos os gêneros com idade variando de 7 a 14 anos foram avaliados. A adiposidade foi caracterizada a partir dos dados obtidos como: índice de massa corporal (IMC, percentual de gordura corporal (%GC e relação cintura-quadril (RCQ. O grupo foi dividido em dois subgrupos (normotensos e hipertensos mediante o nível de pressão arterial (PA. O teste estatístico de Kruskal Wallis foi empregado para determinar a significância na relação entre dados antropométricos e níveis de pressão arterial. Adotou-se um valor de p ? 0,05. Resultados: Verificou-se que 101 (78,29% participantes eram normotensos e 28 (21,71% hipertensos. Em relação à adiposidade, o grupo dos hipertensos apresentou níveis mais elevados de IMC e o %GC quando comparado com o normotenso (p<0,05. A partir dos dados da RCQ, não houve associação estatística entre a relação cintura-quadril e o nível pressórico. Conclusões: As crianças e adolescentes obesos apresentaram relação estatisticamente significativa entre adiposidade corporal e níveis de pressão arterial; no entanto, a localização da gordura não foi um fator determinante desta diferença.

  1. Intercultural Interactions of Mono-Cultural, Mono-Lingual Local Students in Small Group Learning Activities: A Bourdieusian Analysis

    Science.gov (United States)

    Colvin, Cassandra; Fozdar, Farida; Volet, Simone

    2015-01-01

    This research examines the understandings and experiences of mono-cultural, mono-lingual local students in relation to intercultural interactions within small group learning activities at university. Bourdieu's concepts of field, habitus and capital are employed to illuminate a number of barriers to intercultural interaction. Using qualitative…

  2. Mono Lake Excursion in Cored Sediment from the Eastern Tyrrhenian Sea

    Science.gov (United States)

    Liddicoat, Joseph; Iorio, Marina; Sagnotti, Leonardo; Incoronato, Alberto

    2013-04-01

    A search for the Laschamp and Mono Lake excursions in cored marine and lacustrine sediment younger than 50,000 years resulted in the discovery of both excursions in the Greenland Sea (73.3˚ N, 351.0˚ E, Nowaczyk and Antanow, 1997), in the North Atlantic Ocean (62.7˚ N, 222.5˚ E, Channell, 2006), in Pyramid Lake in the Lahontan Basin, NV, USA (40.1˚ N, 240.2˚ E, Benson et al., 2008), and in the Black Sea (43.2˚ N, 36.5˚ E, Nowaczyk et al., 2012). The inclination, declination, and relative field intensity during the Mono Lake Excursion (MLE) in the Black Sea sediment matches well the behaviour of the excursion in the Mono Basin, CA, in that a reduction in inclination during westerly declination is soon followed by steep positive inclination when declination is easterly, and relative field intensity increases after a low at the commencement of the excursion (Liddicoat and Coe, 1979). A large clockwise loop of Virtual Geomagnetic Poles (VGPs) at the Black Sea when followed from old to young patterns very well the VGP loop formed by the older portion of the MLE in the Mono Basin (Liddicoat and Coe, 1979). We also searched for the MLE in cored sediment from the eastern Tyrrhenian Sea (40.1˚ N, 14.7˚ E) where the age of the sediment is believed to be about 32,000 years when comparing the susceptibility in the core with the susceptibility in a nearby one that is dated by palaeomagnetic secular variation records, Carbon-14, and numerous tephra layers in the Tyrrhenian Sea sediment (Iorio et al., 2011). In the Tyrrhenian Sea core, called C1067, closely spaced samples demagnetized in an alternating field to100 mT record a shallowing of positive inclination to 48˚ that is followed by steep positive inclination of 82˚ when declination moves rapidly to the southeast. The old to young path of the VGPs in C1067 forms a narrow counter-clockwise loop that reaches 30.3˚ N, 30.8˚ E and that is centered at about 55˚ N, 15˚ E. Although descending to a latitude that is

  3. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents

    OpenAIRE

    Priscila de Lima Sanches; Marco Túlio de Mello; Francisco Antonio Helfestein Fonseca; Natália Elias; Aline de Piano; June Carnier; Lian Tock; Lila Missae Oyama; Sergio Tufik; Ana Dâmaso

    2012-01-01

    FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo M...

  4. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2

    OpenAIRE

    Cabrera-Pivaral Carlos Enrique; González-Pérez Guillermo; Vega-López María Guadalupe; Arias-Merino Elva Dolores

    2004-01-01

    La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC) en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos...

  5. Modelo educativo nutricional para la reducción de factores de riesgo cardiovascular en niños escolares obesos

    OpenAIRE

    María del Pilar Suárez de Ronderos; Viviana Esquivel Solís

    2003-01-01

    El objetivo de esta investigación fue evaluar la efectividad de un modelo de educación nutricional para la reducción de factores de riesgo de enfermedad cardiovascular en niños escolares obesos. Se realizó un diagnóstico previo para identificar las características generales de este grupo de niños y determinar el estado nutricional, los conocimientos, las actitudes y las prácticas alimentarlas relacionadas con factores de riesgo cardiovascular. El estudio de tipo casi experimental incluyó 31 n...

  6. Dinamização de um programa e intervenção junto de um grupo de adolescentes obesos

    OpenAIRE

    Botelho, Núria Sofia Gomes Queirós

    2013-01-01

    A obesidade é uma doença crónica, que acarreta uma série de implicações de ordem psicossocial, sobretudo na adolescência. Objetivos: No presente estudo pretendeu-se dinamizar um programa de intervenção junto de um grupo de adolescentes obesos, com vista a promover o seu desenvolvimento pessoal e a capacitá-los para lidar de forma mais adaptativa com a obesidade. Método: O programa, constituído por 8 sessões, foi implementado com um grupo de 8 sujeitos de ambos os sexos, com idades compreendid...

  7. Analysis of the stimulated whole saliva in overweight and obese school children Análise da saliva total estimulada em escolares com sobrepeso e obesos

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    Eliana Pannunzio

    2010-01-01

    Full Text Available OBJECTIVE: To determine if some stimulated whole saliva parameters are influenced by an increase of Body Mass Index. METHODS: Controlled cross-sectional study involving 90 school children of both genders between 7 and 10 years of age, from Bragança Paulista - SP. Three groups were formed: overweight, obese and control. Body Mass Index and diet intake by the Food Register method were evaluated. The salivary pH, flow rate, buffer capacity, protein, phosphate, calcium, fluoride, total and free sialic acid, and peroxidase activity were determined. RESULTS: The overweight and obese groups showed greater energy and lipid intake (POBJETIVO: Verificar se alguns parâmetros da saliva total estimulada são influenciados pelo aumento do Índice de Massa Corporal. MÉTODOS: Estudo transversal controlado com 90 escolares, de ambos os sexos, de 7 a 10 anos incompletos de Bragança Paulista, SP, formando três grupos: sobrepeso, obeso e controle. Avaliou-se o Índice de Massa Corporal (P/E2 e a ingestão dietética pelo registro alimentar. Na saliva foram avaliados o fluxo, pH, capacidade tampão e concentrações de proteína, fósforo, cálcio, flúor, ácido siálico livre e total e atividade da peroxidase. RESULTADOS: Nos grupos sobrepeso e obeso houve maior consumo de energia e lipídios (P<0,001. Não houve diferença no fluxo salivar entre todos os grupos, mas somente o controle mostrou valor médio considerado normal. O pH salivar do grupo sobrepeso foi maior do que o do controle (P<0,001. Nos grupos sobrepeso e obeso houve decréscimo na concentração de fosfato (P<0,001 e na atividade da peroxidase (P<0,001. No grupo obeso houve aumento nas concentrações de ácido siálico livre (P= 0,004 e proteína (P= 0,003. CONCLUSÃO: Crianças com sobrepeso e obesas apresentam alterações nas concentrações salivares de fosfato, ácido siálico livre e proteínas e na atividade da peroxidade, as quais favorecem a formação de cárie dentária.

  8. Influencia de un programa de actividad física en niños y adolescentes obesos con apnea del sueño: protocolo de estudio

    OpenAIRE

    M. J. Aguilar Cordero; A. M. Sánchez López; N. Mur Villar; A. Sánchez Marenco; R. Guisado Barrilao

    2013-01-01

    Estudios recientes muestran un incremento alarmante en la tasa de sobrepeso/obesidad entre la población infanto-juvenil. La obesidad en la infancia se asocia con un importante número de complicaciones, como síndrome de apnea del sueño insulinorresistencia y diabetes tipo 2, hipertensión, enfermedad cardiovascular, algunos tipos de cáncer. Se estima que la prevalencia de apnea en niños es de un 2-3% en la población general, mientras que, en adolescentes obesos, varía entre el 13% y el 66%, seg...

  9. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

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    Thiago Bruder Nascimento

    2011-07-01

    Full Text Available FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C e obeso (OB, ratos sob dieta rica em gordura por 30 semanas. Após 30 semanas, foram registrados o peso corporal, índice de adiposidade, pressão arterial e perfis metabólicos e endócrinos dos animais. Foram obtidas curvas para noradrelanina na ausência e presença de inibidor de óxido nítrico sintase (L-NAME, 3x10-4M em aorta torácica intacta e com desnudamento em ratos C e OB. RESULTADOS: As medidas de peso corporal, índice de adiposidade, leptina e insulina aumentaram nos ratos OB, enquanto a pressão arterial permaneceu inalterada. A obesidade também produziu tolerância à glicose e resistência à insulina. A reatividade à noradrenalina da aorta intacta foi similar em ratos C e OB. A presença de L-NAME produziu um aumento similar nas respostas máximas, mas um desvio maior à esquerda das respostas nas aortas intactas dos ratos C em relação aos ratos OB [EC50 (x10-7M: C = 1,84 (0,83-4,07, O = 2,49 (1,41-4,38; presença de L-NAME C = 0,02 (0,01-0,04*, O = 0,21 (0,11-0,40*†,*p < 0,05 vs controle respectivo,†p < 0,05 vs controle mais L-NAME, n = 6-7]. Nenhum dos protocolos alterou a reatividade à noradrenalina de aortas com desnudamento. CONCLUSÃO: A obesidade induzida por dieta rica em gordura promove alterações metabólicas e vasculares. A alteração vascular envolveu uma melhora da via endotelial L-arginina/NO provavelmente relacionada à hiperinsulinemia e hiperleptinemia induzidas por dieta. A maior resistência aos efeitos do L-NAME na aorta de ratos obesos diz respeito a menor vulnerabilidade de indivíduos obesos na presença de patologias

  10. Uso do ultra-som para punção venosa central em paciente obeso com adenomegalia cervical

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    Jaderson Wollmeister

    2008-08-01

    Full Text Available JUSTIFICATICA E OBJETIVOS: As técnicas clássicas para punção venosa central são realizadas com base em referências anatômicas de superfície e conhecimento da anatomia vascular da região em que se realizará a punção. O uso do ultra-som permite a realização da punção sob visão direta das estruturas vasculares, peri-vasculares e da agulha de punção. O objetivo deste relato foi descrever o uso do ultra-som no auxílio de acesso venoso central em paciente obeso e com adenomegalias. RELATO DO CASO: Paciente do sexo masculino, branco, 28 anos, 1,70 m, 120 kg, com diagnóstico de linfoma de Hodgkin esclerose nodular. Solicitado ao Serviço de Anestesiologia do Hospital Governador Celso Ramos, punção de veia jugular interna direita guiada por ultra-som devido à presença de gânglio supraclavicular que prejudicava a referência anatômica de punção e à obesidade do paciente. Após a obtenção da melhor imagem a veia jugular interna esquerda foi puncionada e colocado um cateter venoso de triplo lúmen. A punção foi única, com progressão fácil do cateter e realizada sem complicações. CONCLUSÕES: O uso da ultra-sonografia para punção venosa central pode evitar complicações tornando o procedimento mais seguro para o paciente.

  11. Problematização como estratégia de educação nutricional com adolescentes obesos

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    Rodrigues Érika Marafon

    2006-01-01

    Full Text Available Obesidade é um problema de saúde pública em cuja etiologia determinantes sociais têm relevância, sendo que intervenções com adolescentes encontram condição biopsicossocial complexa. A pesquisa avaliou intervenção de educação nutricional, empregando o método da problematização, com 22 adolescentes obesos, atendidos coletiva e individualmente, durante oito meses. Falas foram coletadas mediante emprego de tarjetas, registro por observador e gravação. O método foi qualitativo e a técnica, a análise de conteúdo. A problematização mostrou-se instrumento facilitador para mudança de comportamento alimentar, fazendo emergir reflexões sobre: práticas alimentares, contexto familiar, estigma social, relacionamento com profissionais de saúde, religiosidade. Os adolescentes em atendimento individual problematizaram com mais efetividade práticas alimentares, enquanto no coletivo houve maior problematização dos aspectos familiares e psicológicos, com efetivas mudanças qualitativas na alimentação de ambos os grupos. Concluiu-se que a intervenção foi eficaz para ajudar os adolescentes a compreenderem sua história de vida e determinantes do comportamento alimentar, efetivarem mudanças na sua alimentação espontaneamente, conscientizarem-se das possibilidades de perpetuação da mudança das práticas alimentares e exercerem com autonomia o papel de sujeitos no cuidado à saúde.

  12. Investigations About the Recording of the Palaeomagnetic Field in the Mono Basin, CA, in Siltstone from a Granitic Provenance

    Science.gov (United States)

    Liddicoat, Joseph; Coe, Robert

    2014-05-01

    For more than three decades, Reidar Lovlie did innovative laboratory and field experiments that advanced our understanding about how sediments acquire a remanent magnetization (Lovlie, 1979, and his subsequent publications about that research). The investigations we and our students have done with lacustrine sediments deposited during the late Pleistocene in the Mono Basin, CA, have benefited from those experiments. One of Lovlie's laboratory experiments that was especially useful in our investigation of the role of relative field intensity (RFI) during a rapidly changing field, the Mono Lake Excursion (MLE; Coe and Liddicoat, 1994), was his study of suspended magnetic grains in slowly curing epoxy resin as the field strength was varied (Lovlie, 1993). More recently we did comparative field and laboratory experiments with sediments from different depositional environments in the Mono Basin that help to explain the recording of the palaeomagnetic field in unweathered siltstone derived from a granitic provenance in the California Sierra Nevada. Our investigations are possible because inclination, declination, and RFI using alternating field and thermal demagnetization and intensity normalizing experiments of magnetic susceptibility (k), saturation isothermal remanent magnetization (SIRM), and anhysteretic remanent magnetization (ARM)(Lund et al., 2005) can be measured with precision for localities separated by as much as 15 kilometres using volcanic ash beds as marker horizons. In addition to making the comparison between localities in the Mono Basin that record the MLE, we have done that for a time interval following the MLE also in the Mono Basin where the palaeomagnetic directions are anomalous compared to secular variation (waveform Delta in Lund et al., 1988; Liddicoat and Coe, 2013). In that interval the RFI is nearly double the RFI during the MLE (Zimmerman et al., 2006), which again allows us to study RFI as a factor in the palaeomagnetic recording process in

  13. Beneficios de la terapia cognitivo-conductual y la presoterapia en pacientes obesos: ensayo clínico aleatorizado Benefits of cognitive behavior therapy and acupressure therapy in obese patients: a randomized clinical trial

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    V. Torres

    2011-10-01

    Full Text Available Objetivo: el objetivo del presente trabajo fue analizar la modificación de los hábitos de vida en pacientes obesos mediante la terapia cognitivo-conductual administrada conjuntamente con la presoterapia. Métodos: Se realizó un estudio experimental con grupo control placebo. Se asignaron de forma aleatoria 40 pacientes a grupo de intervención (terapia cognitivo-conductual + presoterapia y a grupo control (sesiones informativas. La dimensión de estudio fue la administración de un cuestionario sobre valoración y cuantificación de los hábitos de vida relacionados con la obesidad. Las evaluaciones se realizaron en el momento basal y al finalizar los 3 meses de intervención. Resultados: Finalizados los 3 meses de tratamiento, en el grupo de intervención se obtuvieron diferencias significativas (p Objective: The purpose of this study was to analyze change of lifestyle in obese patients with cognitive behavior therapy and acupressure. Methods: An experimental study was performed with placebo control group. Forty patients were randomly assigned to intervention group (cognitive behaviour therapy + acupressure and control group (information session. Outcome measure was a questionnaire for the assessment and quantification of obesity related lifestyles. Measures were performed at baseline and, after 3-months intervention. Results: After 3 months of treatment, the intervention group showed significant differences (p < 0.05 in weight loss, diet and physical activity. Conclusion: In the obese patient, cognitive behavior therapy and acupressure, it has lost at least three kilograms over three months and has changed lifestyles related to obesity.

  14. Professional Android Programming with Mono for Android and NETC#

    CERN Document Server

    McClure, Wallace B; Croft, John J; Dick, Jonathan; Hardy, Chris

    2012-01-01

    A one-of-a-kind book on Android application development with Mono for Android The wait is over! For the millions of .NET/C# developers who have been eagerly awaiting the book that will guide them through the white-hot field of Android application programming, this is the book. As the first guide to focus on Mono for Android, this must-have resource dives into writing applications against Mono with C# and compiling executables that run on the Android family of devices. Putting the proven Wrox Professional format into practice, the authors provide you with the knowledge you need to become a succ

  15. Atitudes de nutricionistas em relação a indivíduos obesos – um estudo exploratório

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    Giuliana da Costa Cori

    2015-02-01

    Full Text Available O objetivo foi identificar atitudes de nutricionistas em relação à obesidade; envolvendo crenças sobre características atribuídas às pessoas obesas, fatores de desenvolvimento e a obesidade em si. Os participantes (N = 344; 97,1% mulheres foram contatados via conselho profissional e responderam a pesquisa online. As questões do estudo foram adaptadas de trabalhos internacionais com as respostas analisadas por frequência de concordância. As respostas indicaram forte estigmatização da obesidade e preconceito contra o obeso, atribuindo características como: guloso (67,4%, não atraente (52,0%, desajeitado (55,1%, sem determinação (43,6% e preguiçoso (42,3%. E considerando entre os mais importantes fatores causais: alterações emocionais e de humor, vício ou dependência de comida e baixa autoestima. Esta temática deve ser mais pesquisada uma vez que tais atitudes podem impactar a eficácia do tratamento; também para discussão e formação ampla sobre os significados da obesidade, e tratamento mais individualizado e humanizado para pacientes obesos.

  16. CORRELAÇÕES DA IMPRESSÃO PLANTAR COM DISFUNÇÕES BIOMECÂNICAS CRÂNIO CERVICAIS E EM MEMBROS INFERIORES EM ADOLESCENTES OBESOS

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    Liana Cardoso Andrade

    2012-06-01

    Full Text Available Introdução: Alteração a nível corporal do indivíduo como a obesidade, se não ocorrer fenômenos adaptativos eficientes, gerados pelo próprio organismo, pode ter graves consequências de distúrbios posturais. Objetivo: Analisar o padrão postural de adolescentes obesos através da biofotogrametria em escola pública de Teresina-PI. Metodologia: A amostra foi composta de 88 adolescentes (10-14anos categorizados em grupo controle GC (n=33, grupo sobrepeso-GS (n=24 e grupo Obeso-GO (n=31. Os escolares foram posicionados e fotografados em posição ortostática frontal anterior, sagital direita e posterior. As pressões plantares foram registradas em um podoscópio. Realizou-se avaliação postural utilizando programa Corew Draw 12 baseado no princípio da fotogrametria. Resultados: A incidência de sobrepeso e obesidade foi de 41, 67 e 67,74% no sexo masculino e 58,33% e 32,26% no sexo feminino. A maior incidência de alterações posturais entre adolescentes GO e GS com pConclusão: A obesidade em adolescentes pode levar a alterações posturais. Palavras-chave: Obesidade. Impressões Plantares. Postura.

  17. Resistivity Imaging of the Mono-Inyo Volcanic Chain, Mono Basin, California Using the Audiomagnetotelluric Method

    Science.gov (United States)

    McPhee, D. K.; Ponce, D. A.; Pera McDonell, A.; Chuchel, B. A.

    2011-12-01

    Audiomagnetotelluric (AMT) models of data collected in Mono Basin, California show significant structure within the upper kilometer of the basin and image a shallow resistor that may be related to a shallow basement feature. The Mono-Inyo volcanic chain is a 25-km long, north-south trending series of domes and craters extending southward from Mono Lake and into the western part of the Long Valley Caldera. Gravity and magnetic modeling in the region, prompted by a volcano hazards study, show a basement high associated with an apparent circular magnetic anomaly. AMT data are used to further investigate this potential field anomaly and image the geoelectric structure within the volcanic rocks in Mono Basin. We collected AMT data along two profiles in Pumice Valley and along the western margin of the domes. Profile A runs approximately east-west, perpendicular to the regional geologic strike, and extends 2.5 km from the southern edge of North Coulee into the basin. Profile B is a north-south trending 6 km-long profile within the basin and was located several hundred meters away from the volcanic chain. Both profiles perpendicularly intersect the circular magnetic feature. We computed both one-dimensional and two-dimensional (2D) inverse models along each profile. 2D models were computed using the conjugate gradient, finite-difference method of Rodi and Mackie (2001) and a 100 ohm-m half-space, starting model. One-dimensional model sensitivity and various 2D starting models indicate a depth of investigation of about 1 km. Preliminary models show a relatively conductive (~20 ohm-m) volcanic basin fill likely associated with the Bishop Tuff, a voluminous pyroclastic flow, whose eruption resulted in formation of the Long Valley caldera 760 Ka ago. Resistivity variations within the basin fill may be related to the porosity or amount of fracturing of individual flows. A resistive (> 200 ohm-m) feature at roughly 600-800 m depth coincides with the magnetic high and relative

  18. Investigations of the Origin of the Magnetic Remanence in Late Pleistocene Lacustrine Sediments in the Mono Basin, CA

    Science.gov (United States)

    Vasquez, N.; Corley, A. D.

    2015-12-01

    In the Mono Basin, CA, fine sand, silt, and volcanic ash deposited in Pleistocene Lake Russell is exposed on the margin of Mono Lake, and on Paoha Island in the lake. The silt records the Mono Lake Excursion (MLE: Denham and Cox, 1971) and several tens of thousands of years of paleomagnetic secular variation (PSV: Denham and Cox, 1971; Liddicoat, 1976; Lund et al., 1988). The sediment is believed to be an accurate recorder of PSV because the MLE has the same signal at widely separated localities in the basin (Denham, 1974; Liddicoat and Coe, 1979; Liddicoat, 1992) with the exception at wave-cut cliffs on the southeast side of the lake (Coe and Liddicoat, 1994). Magnetite, titanomagnetite, and titanomaghemite are present in the sediment (Denham and Cox, 1971; Liddicoat, 1976; Liddicoat and Coe, 1979), which is glacial flour from the adjacent Sierra Nevada (Lajoie, 1968). X-rays of the sediment and lineation measurements show patterns of normal bedding with layers aligned such that the minimum axes are within 5-10 degrees of normal bedding, with 10 percent foliation and 1 percent lineation (Coe and Liddicoat, 1994). We explore reasons for the difference in part of the PSV record at the wave-cut cliffs beyond the interpretation of Coe and Liddicoat (1994) that paleomagnetic field strength is a controlling factor. Possibilities include the sedimentation rate - at localities on the margin of Mono Lake the rate is about 60 percent less than at the wave-cut cliffs - and lithology of the sediment. At Mill Creek on the northwest side of Mono Lake, the non-magnetic sediment fraction is coarser-grained than at the wave-cut cliffs by a factor of about two, and there is a similar difference in the total inorganic carbon (TIC) percentage by weight for the two localities. (Spokowski et al., 2011) Studies of the sediment at two localities in the basin where the Hilina Pali Excursion (Teanby et al., 2002) might be recorded (Wilson Creek and South Shore Cliffs; Liddicoat and Coe

  19. Electron impact single ionization of mono- and di-positive ions

    Indian Academy of Sciences (India)

    M Alfaz Uddin; A K F Haque; M S Mahbub; K R Karim; A K Basak

    2006-06-01

    The electron impact ionization cross-sections of mono- and di-positive ionic targets are calculated using a second version of the modified binary-encounter-dipole (MBED) model, previously reported [M A Uddin et al, J. Phys. B37, 1909 (2004)]. The present version differs from the previous one in the scale factor of the Burgess denominator and is applicable to targets with charges = 1 and 2. The MBED in the present form is found to work well for 11 ionic targets ranging from Be+ to K+ and complements its previous version valid for targets with > 2.

  20. Isotope-specific detection of low density materials with mono-energetic (gamma)-rays

    Energy Technology Data Exchange (ETDEWEB)

    Albert, F; Anderson, S G; Gibson, D J; Hagmann, C A; Johnson, M S; Messerly, M J; Semenov, V A; Shverdin, M Y; Tremaine, A M; Hartemann, F V; Siders, C W; McNabb, D P; Barty, C J

    2009-03-16

    The first demonstration of isotope-specific detection of a low-Z, low density object, shielded by a high-Z and high density material using mono-energetic gamma-rays is reported. Isotope-specific detection of LiH shielded by Pb and Al is accomplished using the nuclear resonance fluorescence line of {sup 7}Li at 0.478 MeV. Resonant photons are produced via laser-based Compton scattering. The detection techniques are general and the confidence level obtained is shown to be superior to that yielded by conventional x-ray/{gamma}-ray techniques in these situations.

  1. Aggregation of manufactured nanoparticles in aqueous solutions of mono- and bivalent electrolytes

    Energy Technology Data Exchange (ETDEWEB)

    Godymchuk, Anna, E-mail: godymchuk@tpu.ru; Karepina, Elizaveta; Yunda, Elena; Bozhko, Irina; Lyamina, Galina [National Research Tomsk Polytechnic University (Russian Federation); Kuznetsov, Denis; Gusev, Alexander [National University of Science and Technology “MISIS” (Russian Federation); Kosova, Natalia [National Research Tomsk State University (Russian Federation)

    2015-05-15

    The study of biological activity of manufactured nanopowders lacks experimental data concerning the influence of electrolyte nature and content on the degree of nanoparticles aggregation in aqueous suspensions. Using the dynamic light scattering technique, it has been shown how the ionic strength (0.0001…100 mM) of mono- and bivalent electrolyte (Na{sup +}, Ca{sup 2+}) solutions influences the size and zeta-potential of Al (90 nm) and Al{sub 2}O{sub 3} (30 nm) nanoparticles. It has been determined that the aggregative effect of counterions decreases when their charge increases. The weaker influence of Ca{sup 2+} concentration on the aggregation of both nanoparticles has been demonstrated. For Al{sub 2}O{sub 3} nanoparticles, the stronger influence of Na{sup +} concentration on the size and charge of aggregates has been observed.

  2. Greater Sage-grouse Telemetry - Mono Co. [ds68

    Data.gov (United States)

    California Department of Resources — Combined telemetry locations for sage grouse in Mono County which were fitted with radio-transmitters for the USGS Greater sage-grouse project. Contains spatial and...

  3. New mono-organotin (IV) dithiocarbamate complexes

    International Nuclear Information System (INIS)

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S2CNR′R″]2 (R= Ph, CH3, R′ = CH3, C2H5, C7H7 and R″ = C2H5, C6H11, iC3H7, C7H7). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, 1H, 13C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm−1 respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The 13C NMR spectra showed an important shift for δ(N13CS2) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S2CN(Et)(i−Pr)]2, MeSnCl[S2CN(Me)(Cy)]2 and MeSnCl[S2CN(i−Pr)(CH2Ph)]2. All structures having a distorted octahedral geometry set by CClS4 donor atom from the two chelating dithiocarbamate ligands

  4. As principais alterações dermatológicas em pacientes obesos Major dermatological changes in obese patients

    Directory of Open Access Journals (Sweden)

    Rosimeri da Silva Castanho Mendonça

    2011-03-01

    Full Text Available INTRODUÇÃO: A obesidade é considerada grave doença crônica que vem atingindo proporções mundiais gerando transtornos sérios para a saúde pública. No Brasil, a prevalência desta doença denota aumento progressivo em relação ao número de pessoas com sobrepeso e/ou obesidade. Apesar disso, as manifestações dermatológicas da obesidade têm sido pouco estudadas. OBJETIVO: Abordar as dermatoses que mais acometem pacientes obesos e seu tratamento, principalmente na aplicação adequada da fisioterapia dermatofuncional. MÉTODO: Revisão da literatura, entre 2000 e 2010, de artigos indexados nas bases Medline/Pubmed, Scielo e Lilacs, livros e monografias das bibliotecas da Universidade de Fortaleza e Universidade Federal do Ceará, Fortaleza, CE, Brasil, cruzando os descritores obesidade, dermatose e fisioterapia. Foram reconhecidas como mais importantes as seguintes situações patológicas: estrias, celulite, acanthosis nigricans, acrocórdons, flacidez, úlcera e impetigo. Entre as formas de tratamento deuse destaque à atuação da fisioterapia dermatofuncional. CONCLUSÃO: O tratamento das dermatoses por meio da fisioterapia dermatofuncional é possível podendo trazer consigo resultados que satisfaçam a expectativa dos pacientes e proporcionando-lhes melhor qualidade de vida.INTRODUCTION: Obesity is a serious chronic disease that has reached global proportions causing problems to public health. In Brazil, the prevalence of this disease shows a progressive increase in the number of people with overweight or obesity. Nevertheless, the skin manifestations have not been well studied. OBJECTIVE: To analyse the dermatosis most affecting obese patients and its treatment, particularly in proper application of dermatological therapy. METHOD: Was made a literature review between 2000 and 2010 of articles published in Medline/ PubMed, SciELO and Lilacs, books and monographs of the libraries of the University of Fortaleza and the Federal

  5. An Analysis of the Magma Supply System at Mono Craters, California. Michelle R. Johnson and Keith Putirka

    Science.gov (United States)

    Johnson, M.; Putirka, K. D.

    2012-12-01

    The Mono Craters consist of 28 sequentially numbered domes, craters, and coulees, oriented north to south, located at the northern end of the Long Valley magmatic system. It is thought that the plumbing system underneath the Mono Craters is a series of dikes, sills, and small magmatic bodies. What remains unclear are the P-T conditions of magma storage and how such conditions may affect upward transport of magma. Seismological constraints exist, which place some magma storage at 8-10 km (Achauer 1986), with the Moho ~30 km (Frasetto et al, 2011). Whole rock analyses and mineral composition data allow us to estimate P and T conditions using mineral-melt thermobarometers and refine magma storage conditions. Pressures were determined using Q-Or-Ab phase relationships. Whole rock compositions indicate that the Mono Craters erupted three compositionally separate batches of magma. Mafic samples at Mono Craters range from 52.7% - 60.45% SiO2, with pressures varying between 1433-2000+ MPa and depths from 44-62+ km. One mafic sample has 43.3% SiO2 with 2000+ MPa and 62+ km depth. Intermediate magmas vary from 63.5% - 67.47% SiO2 with pressures ranging from 508-1527 MPa and depths of 19.2-42.5 km. The felsic magmas range from 71.1% -78.36% SiO2, with pressures varying between 50-521 MPa and depths from 1.9-19.2 km. Harker Diagrams show discontinuity amongst the various compositions. Spatial and geochemical relationships show that there are two areas where mafic magma has erupted: N37.8381 and between N37.9036 - N37.908. Intermediate magmas span a wider range of latitude: N37.8297 - N37.8373 and N37.9018 - N37.9048. Felsic magmas derive from every dome in the Mono Craters system. Mafic magmas, in contrast, derive from just two areas underneath the Mono Craters. We conclude that there are at least two main feeder systems into the Mono Craters magmatic plumbing system, which disperse into a more diffuse system within the lower crust, before being further dispersed at very

  6. Validation of the prognostic Heidelberg re-irradiation score in an independent mono-institutional patient cohort

    OpenAIRE

    Niyazi, Maximilian; Flieger, Maya; Ganswindt, Ute; Combs, Stephanie E; Belka, Claus

    2014-01-01

    Purpose: Re-irradiation has been shown to be a valid option with proven efficacy for recurrent high-grade glioma patients. Overall, up to now it is unclear which patients might be optimal candidates for a second course of irradiation. A recently reported prognostic score developed by Combs et al. may guide treatment decisions and thus, our mono-institutional cohort served as validation set to test its relevance for clinical practice. Patients and methods: The prognostic score is built upon hi...

  7. Correlation of lacustrine paleoclimate records from Mono Lake with the North Atlantic using paleomagnetic intensity

    Science.gov (United States)

    Zimmerman, S. R. H.; Hemming, S. R.; Kent, D. V.

    2003-04-01

    The Wilson Creek Formation of Mono Lake, CA is a Late Pleistocene lacustrine sequence that records major shifts in the paleoenvironment of the lake. It has also been shown to be an excellent recorder of the past variations of the Earth’s magnetic field, and is important as the type section of the Mono Lake Excursion (MLE). As with many terrestrial records, however, it has proven to be very challenging to date the Wilson Creek Fm. at high resolution. Radiocarbon dating has been shown to be vulnerable to contamination with modern carbon, while 40Ar/39Ar dating of the rhyolitic ashes is complicated by inclusion of older xenocrysts. Benson et al. (1998; QR, v. 49, 1-10 ) suggested a correlation to North Atlantic records using paleomagnetic inclination and intensity combined with radiocarbon ages. They argued that δ18O of the Wilson Creek sediments represents variations in lake level, with prominent dry periods (high δ18O) correlating to the North Atlantic Heinrich events. We generated a relative paleointensity record for the Wilson Creek section and propose an alternative correlation to the North Atlantic Paleomagnetic Intensity Stack (NAPIS-75; Laj et al. 2000, Phil. Trans. R. Soc., v. 358, 1009-1025) and the GISP2 age model. It was recently demonstrated by Stoner et al. (2002, QSR v. 21, 1141-1151) that variations in the Earth’s paleomagnetic field intensity are correlative both at high-resolution (10^3 yr) and over long distances (10^4 km). Assuming that the MLE is equivalent to the Laschamp Excursion and that the lake expanded early in Marine Isotope Stage 4, a simple correlation of the major features of the NAPIS-75 and Mono records places the Wilson Creek Fm. on the GISP2 age model, and allows correlation of that paleoclimate record to other records also on that time scale. We also interpret the major δ18O excursions as Heinrich correlatives; however, our correlation equates the three older excursions to H4, H5, and H6 (rather than H3, no correl., and H4

  8. Geochemical fingerprinting of Wilson Creek Formation tephra layers (Mono Basin, CA) using titanomagnetite compositions

    Science.gov (United States)

    Marcaida, M.; Mangan, M.; Vazquez, J. A.; Bursik, M. I.

    2012-12-01

    The Wilson Creek Formation (WCF) near Mono Lake in eastern California is a 6-15 m thick sequence of lake sediments interbedded with 18 rhyolitic tephra layers attributed to eruptions from nearby Mono Craters, and 2 basaltic tephra layers erupted from Black Point and June Lake (not included in study). These tephra layers are numbered 1 to 19 (June Lake tephra designated as Ash 13*) from top to bottom (Lajoie, 1968), and range in age from ~14 to 67 ka (Zimmerman et al., 2006). The WCF tephras are important to understanding volcanism in the Long Valley region, and they provide age constraints for paleomagnetic, paleoclimatic, and paleoecologic studies. Major-oxide compositions of glass for the rhyolitic tephras are similar, with no reported compositional variations between layers. In this study, we show that titanomagnetite compositions can be used to fingerprint specific WCF tephra layers, thus enhancing their use as time-stratigraphic markers. We performed electron microprobe analyses of >700 titanomagnetite crystals and minor ilmenite. Compositional ranges of titanomagnetite are ~83-89 wt% FeO, and ~8-14 wt% TiO2, with MgO+MnO+Al2O3 12 wt%), although Ash 8 has the lowest FeO/TiO2 (~6). Titanomagnetite crystals in the other WCF tephra layers are not as compositionally distinct (FeO/TiO2 = ~7.5-8), although the youngest tephras (Ashes 1- 4) can be distinguished on the basis of MgO content. Ash 15 is unique and exhibits a bimodal population. The composition of Ash 18 titanomagnetites are completely off-trend, with MgO+MnO+Al2O3 ~6 wt% (a factor of 2 difference). Results show that (1) the WCF tephras are compositionally related, but some individual tephras can be distinguished using titanomagnetite compositions. The oldest WCF tephra (Ash 19) had an eruption temperature of ~715°C (Fe-Ti oxide geothermometry of Ghiorso and Evans, 2008), and the general trend of decreasing FeO/TiO2 suggests magmatic temperatures increased for successively erupted Mono Craters rhyolites

  9. New mono-organotin (IV) dithiocarbamate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi (Malaysia)

    2014-09-03

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S{sub 2}CNR′R″]{sub 2} (R= Ph, CH{sub 3}, R′ = CH{sub 3}, C{sub 2}H{sub 5}, C{sub 7}H{sub 7} and R″ = C{sub 2}H{sub 5}, C{sub 6}H{sub 11}, iC{sub 3}H{sub 7}, C{sub 7}H{sub 7}). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, {sup 1}H, {sup 13}C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm{sup −1} respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The {sup 13}C NMR spectra showed an important shift for δ(N{sup 13}CS{sub 2}) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S{sub 2}CN(Et)(i−Pr)]{sub 2}, MeSnCl[S{sub 2}CN(Me)(Cy)]{sub 2} and MeSnCl[S{sub 2}CN(i−Pr)(CH{sub 2}Ph)]{sub 2}. All structures having a distorted octahedral geometry set by CClS{sub 4} donor atom from the two

  10. Dating Lake Tahoe (CA/NV) and Mono Lake (CA) sediment using palaeomagnetic secular variation as a chronology for late Pleistocene palaeoclimate in the U.S. Great Basin

    Science.gov (United States)

    Liddicoat, Joseph

    2010-05-01

    In 1976, six meters of graded and varved sediment were recovered in three piston cores from Lake Tahoe, CA/NV, and used for palaeomagnetic and sedimentologic investigations (Palmer et al., 1979; Denham, 1981). The long-term changes (secular variation) in the Lake Tahoe palaeomagnetic record were compared to secular variation in exposed lacustrine sediment of the Wilson Creek Formation (Lajoie, 1993) in the Mono Basin, CA, (Denham and Cox, 1971), 100 km away. During the more than 30 years since the coring was done in Lake Tahoe, the record of palaeomagnetic secular variation in the Mono Basin and elsewhere in the Great Basin has been refined (Liddicoat and Coe, 1979; Lund et al., 1988, Liddicoat and Coe, 1997; Liddicoat and Coe, 1998; Benson et al., 1998; Negrini and Davis, 1992; Kent et al., 2002; Zimmerman et al., 2006) to allow a reexamination of the palaeomagnetic directions and environmental magnetic record in the Lake Tahoe cores and the age of those sediments. Inferences are also possible about the sedimentological importance during the recording of the palaeomagnetic field at Lake Tahoe and possibly in the Mono Basin, and the age of the Lake Tahoe sediment recovered, which postdates the Mono Lake Excursion. The age of the Mono Lake Excursion and Wilson Creek Formation is relevant to investigations of Late Pleistocene palaeoclimate reconstructions for the U.S. Great Basin (Zimmerman et al., 2006).

  11. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    Full Text Available FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo Modelo de Avaliação da Homeostase (HOMA-RI: com resistência insulínica (RI n = 39 e sem resistência insulínica (NRI n = 27, e foram submetidos a uma intervenção interdisciplinar ao longo de um ano. A espessura mediointimal da artéria carótida comum (EMIC, e o tecido adiposo visceral e subcutâneo foram determinados por ultrassonografia. A composição corporal, pressão arterial, índice HOMA-RI, perfil lipídico e as concentrações de adipocinas [leptina, adiponectina, e inibidor do ativador do plasminogênio-1 (PAI-1] foram analisados antes e após a terapia. RESULTADOS: Ambos os grupos apresentaram melhoras significativas na composição corporal, estado inflamatório (redução da concentração de leptina e PAI 1; aumento de adiponectina plasmática e redução da EMIC. Apenas o grupo NRI mostrou correlação positiva entre as alterações na gordura visceral (∆Visceral e mudanças na EMIC (∆ EMIC (r = 0,42, p < 0,05. A análise por regressão linear simples revelou o ∆Visceral ser um preditor independente para a redução da EMIC nesse grupo (R2 ajustado = 0,14, p = 0,04. Os valores finais da EIMC permaneceram significativamente maiores no grupo RI, quando comparado com grupo NRI. CONCLUSÃO: A presença de resistência insulínica pode prejudicar mudanças na EMIC levando ao desenvolvimento precoce da aterosclerose em adolescentes obesos submetidos a uma intervenção interdisciplinar.

  12. P ET CO2 e SpO2 permitem ajuste ventilatório adequado em pacientes obesos mórbidos P ET CO2 y SpO2 permiten ajuste de ventilación adecuada en pacientes obesos mórbidos P ET CO2 and SpO2 allow adequate ventilatory adjustment in morbidly obese patients

    OpenAIRE

    Fábio Ely Martins Benseñor; José Otávio Costa Auler Júnior

    2004-01-01

    JUSTIFICATIVA E OBJETIVOS: Apesar das diversas propostas ventilatórias para anestesia em pacientes obesos mórbidos, um consenso não foi estabelecido. Este estudo avaliou o ajuste ventilatório nestes pacientes durante anestesia baseado na oximetria e capnografia. MÉTODO: O consentimento prévio foi obtido da Comissão de Ética e dos pacientes. Excluíram-se tabagistas e portadores de doença cardíaca ou pulmonar. Foram estudados 11 pacientes com índice de massa corpórea (IMC) de 59,2 ± 8,3 submeti...

  13. Sorption of mono ethanol amine and mono ethanol aminate of copper(II) and cadmium(II) on hydrated zirconium dioxide

    International Nuclear Information System (INIS)

    The sorption of mono ethanol amine and mono ethanol aminate of copper(II) and cadmium(II) on hydrated zirconium dioxide is studied. Influence of ph of equilibrium solution, nature of central cation and outer-sphere anion on sorption of mono ethanol amine on hydrated zirconium dioxide is considered.

  14. Temporal correlation of U. S. Great Basin lake sediments below the Mono Lake Excursion using paleomagnetic secular variation

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.; Negrini, R. M.; Knott, J. R.; Lund, S.; Benson, L. V.

    2015-12-01

    Beginning nearly 50 years ago with a paleomagnetic study of exposed lacustrine sediments in the Mono Basin, CA (Denham and Cox, 1971), there have been subsequent studies to document paleomagnetic secular variation (PSV) in the basin and to establish a chronology for that record (Vazquez and Lidzbarski, 2012). We report a paleomagnetic secular variation (PSV) investigation of lacustrine sediments in the Mono Basin, CA, that extends the base of the PSV record of Lund et al. (1988) by about 20 percent. We did our investigation at two localities separated by about 4 km on the southeastern and eastern sides of Mono Lake: South Shore Cliffs (SSC) and Warm Springs (WS). The sampled interval at SSC is from 0.1 m above to 2.2 m below Wilson Creek Ash 19 in the tephrostratigraphy of Lajoie (1968), ending in loose sand. At WS, we sampled from Ash 17 to 1.0 m below Ash 19, a total of 2 m. At SSC using back-to-back horizons 2-cm thick containing one to three samples each that were a.f. or thermally demagnetized, we found rapidly fluctuating PSV in the interval from ~ 0.3 to 1.0 m below Ash 19. The fluctuating PSV contains a change in declination of ~ 80˚ from 308˚ (n = 3, α-95: 6.1˚) to 29˚ (n = 3, α-95: 11.5˚) within a single hand sample that spans 14 cm. Inclination during that change in declination gradually rose from 56˚ to 63˚ and increased to 70˚ before reducing to a minimum of 29.9˚. The path of the Virtual Geomagnetic Poles when the declination is most westerly forms a narrow loop that reaches 49.7˚ N latitude near 170˚ E longitude. At WS the westerly swing in declination is absent, but the easterly declination and relatively steep inclination described above are recorded. A study of the relative paleomagnetic intensity (RPI) shows that the maximum RPI is ~1.5 m below Ash 19 and decreases to a minimum ~6 cm above the ash. Distinct PSV and RPI features below the Mono Lake excursion correlate well between records from the periphery of Mono Lake and those from

  15. Ensayo clínico aleatorizado con una galleta enriquecida en inulina en el patrón de riesgo cardiovascular de pacientes obesos Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2010-02-01

    Full Text Available Introducción: La inulina es un prebiótico con potenciales efectos beneficiosos a nivel cardiovascular. El objetivo de nuestro trabajo es evaluar la respuesta del perfil de riesgo cardiovascular en pacientes obesos tras la inclusión en la dieta de una galleta enriquecida en inulina. Material y métodos: Un total de 34 pacientes fueron randomizados a una de las siguientes ramas: galleta I (enriquecida con inulina, ver tabla I y galleta II (galleta control, ver tabla I (Gullón SL. Cada paciente recibió un total de 8 galletas al día (total de 68 gramos de producto. Antes de iniciar el tratamiento y al mes se realizóuna valoración nutricional y analítica. Resultados: Finalizaron un total de 15 pacientes en cada grupo. En el grupo I se produjo un aumento significativo en la ingesta de fibra soluble (inulina. Se detectó en los pacientes con las galletas enriquecidas en inulina una disminución significativa de los niveles de colesterol total (223,1 ± 45,3 mg/dl vs 208,8 ± 33,1 mg/dl; p Introduction: Inulin is a prebiotic with potential benefit in cardiovascular risk factors. The aim of our work is to evaluate in obese patients the effect of a inulin enriched cookie on cardiovascular risk factors. Material and methods: 34 patients were randomized in both branches: group I (inulin enriched cookie Gullon SL® and group II (control cookie. Previous and after 1 month of the treatment, a nutritional and biochemical study was realized. Results: 15 patients finished the procotol in each group. In group I, an increase in soluble fiber intake (inulin was detected. In this group a significant decrease of total cholesterol (223.1 ± 45.3 mg/dl vs 208.8 ± 33.1 mg/dl; p < 0.05 and LDL cholesterol (142.9 ± 39.2 mg/dl vs 131.4 ± 28.6 mg/dl; p < 0.05 was reached. A non significant improvement in insulin levels and HOMA was detected in inulin-enriched cookie group, too. Anthropometric parameters did not change in both groups. The increase in soluble fiber

  16. Padrões alimentares de adolescentes obesos e diferentes repercussões metabólicas Dietary patterns of obese adolescents and different metabolic effects

    OpenAIRE

    Vera Regina Mello Dishchekenian; Maria Arlete Meil Schimith Escrivão; Domingos Palma; Fábio Ancona-Lopez; Eutália Aparecida Candido de Araújo; José Augusto de Aguiar Carrazedo Taddei

    2011-01-01

    OBJETIVO: Avaliar a associação de padrões alimentares com alterações metabólicas em adolescentes obesos. MÉTODOS: Estudo transversal envolvendo 76 estudantes (ambos os sexos, 14-19 anos, IMC³P95 e Tanner ³4) de escolas públicas da cidade de São Paulo, Brasil. Foram coletados dados antropométricos e bioquímicos, e aplicados questionários com informações sociodemográficas e registro alimentar de 4 dias, entre 2006 e 2007. Escores fatoriais foram obtidos na análise fatorial e, após ajustes, três...

  17. Influência do tratamento fisioterapêutico no pós-operatório de obesos mórbidos

    OpenAIRE

    Ferreiro, Adriana

    2013-01-01

    Objetivo: As cirurgias abdominais em obesos mórbidos levam a disfunções respiratórias associada as complicações pós-operatórias. Analisar as técnicas de fisioterapia respiratória mais eficazes no tratamento de disfunções pulmonares no pós-operatório de cirurgia bariátrica. Metodologia: Foi realizada uma pesquisa bibliográfica nas bases da Scielo, Pub Med, B-on. Resultados: Após a análise de todos os artigos, foram incluídos neste estudo uma revisão bibliográfica de 7 artigos envolvendo 147 pa...

  18. Consumo alimentar e gasto energético em adolescentes obesos e eutróficos Food consumption and energy expenditure in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Camila Dayrell

    2009-12-01

    Full Text Available OBJETIVO: Comparar, entre adolescentes obesos e eutróficos, variáveis relacionadas ao consumo alimentar e ao gasto energético. MÉTODOS: Estudo transversal com 23 adolescentes recrutados em escolas e centros de recreação de São Paulo (SP, distribuídos em dois grupos: 11 obesos e 12 eutróficos. Foram avaliados: peso corporal, estatura, índice de massa corporal, circunferência da cintura, massa magra e massa gorda (estimados por bioimpedância elétrica, três recordatórios alimentares de 24 horas, estimativa do gasto energético diário a partir de três métodos (recordatórios de atividade física, fórmulas preditivas e calorimetria indireta, gasto energético de repouso e a potência aeróbia. RESULTADOS: O gasto energético diário dos obesos foi maior, porém a ingestão alimentar se assemelhou à dos eutróficos. Não foram encontradas diferenças no gasto energético de repouso entre os grupos, porém a potência aeróbia foi maior nos eutróficos. A dieta de ambos os grupos não foi considerada saudável, mas os obesos apresentaram menor consumo de vários alimentos considerados saudáveis, como hortaliças. Observou-se discrepância na análise do gasto energético diário, quando se adotaram diferentes métodos. CONCLUSÕES: Os adolescentes apresentaram padrão alimentar associado ao risco de obesidade e doenças crônicas. Mais estudos são necessários para identificar melhores métodos para avaliar seu gasto energético. É urgente a busca de estratégias de educação nutricional específicas para esse grupo etário.OBJECTIVE: To compare food consumption and energy expenditure between obese and non-obese adolescents. METHODS: This cross-sectional study comprised 23 adolescents recruited from schools and recreation centers from São Paulo (SP, Brazil, distributed in two groups: 11 obese and 12 non-obese. The following variables were analyzed: body weight, height, body mass index, waist circumference, fat and lean mass

  19. Leachable Li and Mg Evidence for Hydrological Changes in the Mono Basin, CA, USA

    Science.gov (United States)

    Sahajpal, R.; Hemming, N.; Zimmerman, S. R.; Hemming, S. R.

    2007-12-01

    Hydrology in closed basin lakes, such as Mono Lake of the US western Great Basin, is sensitive to regional climate changes. Lake level history of the Mono Basin has been put into a precise age framework using the paleomagnetic intensity of the Wilson Creek Formation sediments to North Atlantic records, and accordingly Greenland's GISP2 oxygen isotope record (Zimmerman et al., 2006, EPSL, v. 252, pp. 94- 106). This allows correlation of the lake level indicators and Greenland climate at high resolution. The physical evidence for lake level, based on the association of strata in near shore terraces, can be confidently correlated to proxies of lake chemistry preserved in the strata. We have tested the application of leachable Li, following the procedure developed by Bischoff et al. (1997, Quaternary Research, v. 48, pp. 313-325) for Owens Lake. At Owens Lake there is a positive correlation between salinity based on diatoms with leachable Li concentrations. In contrast, at Mono Lake the leachable Li concentration follows the bulk carbonate concentration, generally correlating low lake levels (high salinity) with low leachable Li concentrations. Our preferred explanation for both the carbonate and leachable Li concentrations is based on the fact that the Mono Basin rarely overflows, and therefore precipitation of minerals during evaporation leads to chemical divides (Garrels and Mackenzie., 1967, in "Equilibrium Concepts in Natural Water Systems", W. Stumm, Ed., pp. 222-242). As Li behaves conservatively compared to elements like Ca2+ and Mg2+, it might be expected that the leachable Li would be higher when lake level is lower. However, the host for the Li appears to be Mg-smectite. Therefore, the concentration of leachable Li in the sediment is controlled by the concentration of Mg-smectite, as well as the Li/Mg of the water from which the Mg- smectite precipitated and the Kd of the Li into the Mg-smectite. We are studying the Li and Mg systematics of these samples in

  20. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten;

    2015-01-01

    No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution for inno......No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution...... for innovative and cost-effective design of Mono Bucket foundations. Established approach merges wind and wave load models, soil/structure interaction topics, structural optimization and installation/fabrication aspects, into software package with ability to perform optimal design of the individual foundations...

  1. Mono-Higgs signature in fermionic dark matter model

    CERN Document Server

    Ghorbani, Karim

    2016-01-01

    In light of Higgs boson discovery, we explore mono-Higgs signature in association with dark matter pair production at the LHC. For two channels with $\\gamma\\gamma+\\text{MET}$ and $b \\bar b+\\text{MET}$ in the final state we simulate the SM backgrounds and signal events at $\\sqrt{s} = 14$ TeV. We then estimate the LHC sensitivities for various benchmark points for two integrated luminosities ${\\cal L} = 300~\\text{fb}^{-1}$ and ${\\cal L} = 3~ \\text{ab}^{-1}$. We constrain the Yukawa coupling of the dark matter-SM interaction, taking into account bounds from mono-Higgs signature, observed dark matter relic density, Higgs physics and perturbativity requirement. Concerning the mono-Higgs search, it turns out that the channel with the largest branching ratio, $b \\bar b$ channel, provides better sensitivity.

  2. [Immediately loaded MonoType implants in the edentulous mandible].

    Science.gov (United States)

    Gfeller, F; Zitzmann, N U; Lambrecht, J Thomas

    2011-01-01

    Results of immediately loaded implants are presented. 34 patients with 136 interforaminal MonoType implants (Straumann,Basel, Switzerland) were included in the study. The bar retention was manufactured fter the operation, inserted and covered with a hybrid prosthesis. 28 patients showed up for the follow-up study, the average time range was three years. Five implants were rated as failures, the cumulative six-year success rate being 94%. Interforaminal immediately loaded MonoType implants in edentulous patients showed very good results, comparable to similar studies with different systems. PMID:21560796

  3. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard;

    for the fatigue limit state is a significant failure mode for the Mono.tower platform. Further, it is shown for the fatigue failure mode the the largest contributions to the overall uncertainty are due to the damping ratio, the inertia coefficient, the stress concentration factor, the model uncertainties......In this paper a reliability analysis of a Mono-tower platform is presented. The failure modes, considered, are yelding in the tube cross-sections, and fatigue failure in the butt welds. The fatigue failure mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...

  4. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard;

    1990-01-01

    that the fatigue limit state is a significant failure mode for the Mono-tower platform. Further, it is shown for the fatigue failure mode that the largest contributions to the overall uncertainty are due to the damping ratio, the inertia coefficient, the stress concentration factor, the model uncertainties......In this paper, a reliability analysis of a Mono-tower platform is presented. Te failure modes considered are yielding in the tube cross sections and fatigue failure in the butts welds. The fatigue failrue mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...

  5. Padrões alimentares de adolescentes obesos e diferentes repercussões metabólicas Dietary patterns of obese adolescents and different metabolic effects

    Directory of Open Access Journals (Sweden)

    Vera Regina Mello Dishchekenian

    2011-02-01

    Full Text Available OBJETIVO: Avaliar a associação de padrões alimentares com alterações metabólicas em adolescentes obesos. MÉTODOS: Estudo transversal envolvendo 76 estudantes (ambos os sexos, 14-19 anos, IMC³P95 e Tanner ³4 de escolas públicas da cidade de São Paulo, Brasil. Foram coletados dados antropométricos e bioquímicos, e aplicados questionários com informações sociodemográficas e registro alimentar de 4 dias, entre 2006 e 2007. Escores fatoriais foram obtidos na análise fatorial e, após ajustes, três padrões alimentares identificados foram associados a fatores de risco biológico por regressão linear múltipla. RESULTADOS: O padrão Tradicional (arroz e massas, feijões, carnes vermelhas, embutidos, óleos e doces foi positivamente associado com insulina, glicemia e triglicérides e negativamente associado com lipoproteína de alta densidade. O padrão Em Transição (peixe, aves, ovos, pães, manteiga, leite e derivados, hortaliças, frutas, sucos de frutas e açúcar refinado apresentou as mesmas associações, além de associação similar com a pressão arterial diastólica. O padrão Fast Food (cafeteria, hambúrguer, maionese, bolacha, bolos e tortas, chocolate e refrigerantes apresentou associação positiva com o colesterol, lipoproteína de baixa densidade e pressão arterial sistólica e diastólica, e associação negativa com insulina e lipoproteína de alta densidade. CONCLUSÃO: Os padrões Tradicional e Em transição apresentaram associações diferentes com o metabolismo lipídico e glicídico quando comparados com o padrão Fast Food. Os três padrões podem ser considerados obesogênicos, porém o padrão Fast Food pareceu ser o mais aterogênico e promotor de hipertensão arterial.OBJECTIVE: This study assessed the association between dietary patterns and metabolic changes in obese adolescents. METHODS: This was a cross-sectional study of 76 students (both genders, 14-19 years old, BMI³P95 and Tanner stage ³4

  6. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2 Impact of participatory education on body mass index and blood glucose in obese type-2 diabetics

    Directory of Open Access Journals (Sweden)

    Carlos Enrique Cabrera-Pivaral

    2004-02-01

    Full Text Available La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos de pacientes diabéticos obesos. La intervención educativa-participativa se organizó mediante el proceso de reflexión-acción. Se efectuaron mediciones del IMC basal y mensuales durante los 9 meses de la intervención educativa. Los grupos fueron controlados tomando en cuenta edad y sexo. El análisis estadístico se efectuó con el estadígrafo de t de students con diferencia de media para grupos relacionados. El grupo control logra un valor promedio de IMC basal de 33.89 ± 1.96 y al final de 33.2 ± 2.15 (t: 22.4; p: 0.16, el grupo de experimento con valor inicial de 33.63 ± 2.12 y final de 31.54 ± 1.71 (t: 11.55; p = 0.003. La intervención educativa participativa contribuye a mejorar el nivel de IMC en los diabéticos obesos 2.Exogenous obesity increases morbidity and mortality risk and has been associated with nutritional habits, which in turn can be affected by health education. Health education aims to promote patient participation in achieving behavior change and healthy lifestyles. The objective of this study is to show the advantages of participatory education in the modification of body mass index (BMI in obese type-2 diabetics. A quasi-experimental study was performed with random allocation of two patient groups. The educational intervention was organized through a reflection-action process. BMI was measured at baseline and then monthly for 9 months during the intervention. The groups were analyzed by age and sex. Statistical

  7. Tagging a mono-top signature in Natural SUSY

    CERN Document Server

    Goncalves, Dorival; Takeuchi, Michihisa

    2016-01-01

    We study the feasibility of probing a region of Natural Supersymmetry where the stop and higgsino masses are compressed. Although this region is most effectively searched for in the mono-jet channel, this signature is present in many other non-supersymmetric frameworks. Therefore, another channel that carries orthogonal information is required to confirm the existence of the light stop and higgsinos. We show that a supersymmetric version of the $t \\bar t H$ process, $pp \\to t \\tilde t_1 \\tilde \\chi^0_{1(2)}$, can have observably large rate when both the stop and higgsinos are significantly light, and it leads to a distinctive mono-top signature in the compressed mass region. We demonstrate that the hadronic channel of the mono-top signature can effectively discriminate the signal from backgrounds by tagging a hadronic top-jet. We show that the hadronic channel of mono-top signature offers a significant improvement over the leptonic channel and the sensitivity reaches $m_{\\tilde t_1} \\simeq 420$ GeV at the 13 ...

  8. 21 CFR 184.1505 - Mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... prepared from fats or oils or fat-forming acids that are derived from edible sources. The most prevalent fatty acids include lauric, linoleic, myristic, oleic, palmitic, and stearic. Mono- and diglycerides are manufactured by the reaction of glycerin with fatty acids or the reaction of glycerin with triglycerides in...

  9. Air quality in bedded mono-slope beef barns

    Science.gov (United States)

    Bedded mono-slope barns are becoming more common in the upper Midwest. Because these are new facilities, little research has been published regarding environmental quality, building management and animal performance in these facilities. A team of researchers from South Dakota State University, USDA ...

  10. Geophysical studies of Mono Lake, east-central California

    Science.gov (United States)

    Athens, N. D.; Ponce, D. A.

    2012-12-01

    Magnetic and gravity investigations were undertaken in Mono Lake, California to study regional crustal structures and to aid understanding the geologic framework of Mono Lake, in particular regarding potential geothermal resources and volcanic hazards throughout Mono Basin. Recent geophysical surveys included over 600 line-kilometers of high-resolution ship-borne magnetometer data that augmented existing airborne data, 22 line-kilometers of ground magnetic data that were collected along six traverses across Paoha Island, 56 gravity stations that were collected on Paoha and Negit Islands, and 28 rock samples that were collected for physical property data. Magnetic highs in the study area occur to the east and west of Mono Lake, where pre-Tertiary basement is exposed. Magnetic data indicate that Mono Lake itself is dominated by three prominent magnetic anomalies that are from west to east: a magnetic high along the northwest part of the lake associated with the moderately magnetic basalt cinder cone at Black Point, a magnetic high associated with the young volcanic centers at Paoha and Negit Islands, and a broad magnetic high along the eastern margin of the lake probably associated with moderately magnetic granitic basement rocks at depth. Because volcanic rocks exposed at the surface of Paoha and Negit Islands are only weakly magnetic, magnetic data suggest that more mafic volcanic rocks probably occur at depth and are the source of the anomaly. The linear and steep magnetic gradient across the eastern part of the lake may reflect a fault. A fault may also be imaged in the northeastern part of the lake, where a possible laterally offset magnetic anomaly may be present. Within Mono Lake, gravity station control is poor because land-based gravity stations are limited to Paoha and Negit Islands. The gravity low in the basin reflects a moderately deep sedimentary basin filled with low density lacustrine and volcanic deposits. Isostatic gravity data indicate the central

  11. Dissecting simulated disk galaxies I: the structure of mono-age populations

    CERN Document Server

    Martig, Marie; Flynn, Chris

    2014-01-01

    We study seven simulated disk galaxies, three with a quiescent merger history, and four with mergers in their last 9 Gyr of evolution. We compare their structure at z=0 by decomposing them into "mono-age populations" (MAPs) of stars within 500 Myr age bins. All studied galaxies undergo a phase of merging activity at high redshift, so that stars older than 9 Gyr are found in a centrally concentrated component, while younger stars are mostly found in disks. We find that most MAPs have simple exponential radial and vertical density profiles, with a scale-height that typically increases with age. Because a large range of merger histories can create populations with simple structures, this suggests that the simplicity of the structure of mono-abundance populations observed in the Milky Way by Bovy et al. (2012b,c) is not necessarily a direct indicator of a quiescent history for the Milky Way. Similarly, the anti-correlation between scale-length and scale-height does not necessarily imply a merger-free history. How...

  12. Comparação entre a prevalência de transtornos mentais em pacientes obesos e com sobrepeso = Comparison between the prevalence of mental disorders in obese and overweight patients

    Directory of Open Access Journals (Sweden)

    Verdolin, Louise Deluiz

    2012-01-01

    Conclusões: Transtornos ansiosos foram mais prevalentes em pacientes obesos quando comparados aos pacientes com sobrepeso, alguns transtornos psíquicos associaram-se a obesidade grave e transtornos depressivos foram mais prevalentes em pacientes com circunferência da cintura muito aumentada. Estes resultados reafirmam a importância de considerar a abordagem psiquiátrica no manejo clínico da obesidade

  13. Pyrogen testing of lipid-based TPN using Mono Mac 6 monocyte cell line and DELFIA

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    1997-01-01

    Measurement of lipopolysaccharide (LPS) induced interleukin-6 (IL-6) secretion in Mono Mac 6 cells.......Measurement of lipopolysaccharide (LPS) induced interleukin-6 (IL-6) secretion in Mono Mac 6 cells....

  14. Quaternary Eruptions of the Mono-Inyo Craters, California

    Science.gov (United States)

    Bursik, M. I.; Pouget, S.; Mangan, M.; Marcaida, M.; Vazquez, J. A.

    2013-12-01

    The eruptive products of the Mono-Inyo Craters volcanic chain include the tephra and associated volcanic rocks of Black Point, islands of Mono Lake, Mono Craters, Inyo Craters, late eruptions of Mammoth Mountain and Red Cones. Most of the eruptions were explosive, and generated numerous pyroclastic flows, surges and falls as well as the prominent domes and lava flows that now cover vents. The eruptions range in age from several hundred years to at least 60,000 yr BP. The Mono-Inyo tephras are dispersed throughout the Sierra Nevada and Basin and Range, providing key time-stratigraphic marker layers. Recent work has not only resulted in high-precision radiometric dating of many of the tephras, but also detailed geochemical data that for the first time provides fingerprinting sufficiently precise to discriminate among the tephras. Lithostratigraphy of many of the layers is herein described for the first time, based on careful sampling and description in the field, and laboratory grain size, grain shape and componentry analyses of the late Pleistocene tephras of the Wilson Creek Formation. Most of the Wilson Creek volcanic layers are fall deposits accumulated within paleolake Russell, which were generated by eruptions of variable intensity and influenced by paleowinds of different orientation. Prevailing winds were generally to the North and East, but often the Pleistocene layers less than 25 ka were dispersed to the West. Many of the fall layers show evidence of wave reworking, generally near the top, although in some cases it is pervasive. Only near the vent do some layers of apparent debris flow origin occur. Maximum pumice sizes range up to nearly 3 cm, and lithics range up to 1 cm in the rhyolitic fall beds, while thicknesses range up to c. 30 cm. These data are consistent with relatively low volume, subplinian style eruptive behavior for most of the life of the Mono-Inyo Craters.

  15. Possible recording of the Mono Lake Excursion in cored sediment from Clear Lake, California

    Science.gov (United States)

    Liddicoat, Joseph; Verosub, Kenneth

    2010-05-01

    extrapolation between those dates and the three dates from higher in the core. The age of the possible palaeomagnetic excursion in the Clear Lake sediment is in reasonable agreement with the age assigned to the MLE by Benson et al. (2003; 2008) and is nearly 10,000 years younger than the Laschamp Excursion (Guillou et al., 2004). We believe that is an indication that the anomalous field behaviour known as the Mono Lake Excursion in the Mono Basin (Denham and Cox, 1971; Liddicoat and Coe, 1979) and possibly at Clear Lake is not the Laschamp Excursion.

  16. Comparação das variáveis cardiorrespiratórias de adolescentes obesos e não obesos em esteira e bicicleta ergométrica Comparison of the cardiorespiratory variables of obese and non-obese adolescents on treadmill and ergometric bicycle

    Directory of Open Access Journals (Sweden)

    Gerusa Eisfeld Milano

    2009-08-01

    Full Text Available O objetivo deste estudo foi investigar o consumo máximo de oxigênio (VO2max em adolescentes obesos e não obesos em esteira e bicicleta ergométrica. O estudo foi transversal e descritivo com a amostra de 54 indivíduos obesos (23 meninos e 31 meninas e 33 não obesos (16 meninos e 17 meninas com idade entre 10 e 16 anos. Utilizou-se o critério dos Centers for Disease Control and Prevention (CDC, 2000 para a classificação do índice de massa corporal (IMC. Foram avaliados o peso, estatura, índice de massa corporal (IMC e IMC-escore Z. Para avaliação cardiorrespiratória foi realizado teste máximo em esteira e bicicleta ergométrica. Foram avaliados a frequência cardíaca máxima (FCmax, coeficiente respiratório (RER, consumo máximo de oxigênio (VO2max, tempo total de teste (TT e carga final (w na bicicleta ergométrica. Utilizou-se o teste de t de Student para a comparação dos ergômetros. Nas análises dos grupos, utilizou-se a ANOVA fatorial. Considerou-se significante p The aim of this study was to investigate the oxygen maximal uptake (VO2max in obese and non-obese adolescents on treadmill and ergometric bicycle. The study was transversal and descriptive with a sample of 54 obese individuals (23 boys and 31 girls and 33 non-obese individuals (16 boys and 17 girls, mean age of 10-16 years. The criterion by the Centers for Disease Control and Prevention (CDC, 2000 was used for classification of body mass index (BMI. Weight, height, body mass index (BMI and BMI-score Z were assessed. A maximal test on treadmill and ergometric bicycle was performed for cardiorespiratory assessment. Maximum heart rate (HRmax, respiratory coefficient (REC, maximal oxygen uptake (VO2max, test total time (TT and final load (w on ergometric bicycle were assessed. Student's t-test was used for ergometers comparison. Factorial ANOVA was used in the groups'analysis and p< 0.05 was considered significant. The results revealed that weight, BMI and BMI

  17. Mono Lake Analog Mars Sample Return Expedition for AMASE

    Science.gov (United States)

    Conrad, P. G.; Steele, A.; Younse, P.; DiCicco, M.; Morgan, A. R.; Backes, P.; Eigenbrode, J. E.; Marquardt, D.; Amundsen, H. E. F.

    2011-01-01

    We explored the performance of one robotic prototype for sample acquisition and caching of martian materials that has been developed at the Jet Propulsion Laboratory for potential use in the proposed MAX-C Mars Sample Return architecture in an environment, rich in chemical diversity with a variety of mineralogical textures. Mono Lake State Tufa Reserve in Mono County, CA possesses a variety of minerals including a variety of evaporites, volcanic glass and lava, and sand and mudstones. The lake itself is an interesting chemical system: the water is highly alkaline (pH is approximately 10) and contains concentrations of Cl, K, B, with lesser amounts of S Ca Mg, F, As, Li, I and Wand generally enriched HREEs. There are also traces of radioactive elements U, Th, Pl.

  18. Permeability of mono- and bi-dispersed porous media

    Directory of Open Access Journals (Sweden)

    Kim S.J.

    2013-04-01

    Full Text Available In this study, the permeability of mono- and bi-dispersed porous media is considered. The effects of the particle size distribution and the packing structure of particles on the permeability are investigated experimentally and analytically. Both experimental and analytic results suggest that the particlesize distribution is close to the log-normal distribution, and the permeability of the mono-dispersed porous media quasi-linearly decreases as the range of the particle size distribution increases. On the other hand, the effect of packing structure of particles on the permeability is shown to be negligible.The permeability of the bidispersed porous media quasi-linearly decreases as the range of cluster size increases, and nearly independent of the particle size distribution. The present model is valid over the range of parameters typically found in heat transfer applications.

  19. Post-middle Miocene Tuffs of Bodie Hills and Mono Basin, California: Paleomagnetic Reference Directions and Vertical Axis Rotation

    Science.gov (United States)

    Lindeman, J. R.; Pluhar, C. J.; Farner, M. J.

    2013-12-01

    The relative motions of the Pacific and North American plates about the Sierra Nevada-North American Euler pole is accommodated by dextral slip along the San Andreas Fault System (~75%) and the Walker Lane-Eastern California Shear Zone system of faults, east of the Sierra Nevada microplate (~25%). The Bodie Hills and Mono Basin regions lie within the Walker Lane and partially accommodate deformation by vertical axis rotation of up to 60o rotation since ~9.4 Ma. This region experienced recurrent eruptive events from mid to late Miocene, including John et al.'s (2012) ~12.05 Ma Tuff of Jack Springs (TJS) and Gilbert's (1968) 11.1 - 11.9 Ma 'latite ignimbrite' east of Mono Lake. Both tuffs can be identified by phenocrysts of sanidine and biotite in hand specimens, with TJS composed of a light-grey matrix and the latite ignimbrite composed of a grey-black matrix. Our paleomagnetic results show these units to both be normal polarity, with the latite ignimbrite exhibiting a shallow inclination. TJS's normal polarity is consistent with emplacement during subchron C5 An. 1n (12.014 - 12.116 Ma). The X-ray fluorescence analyses of fiamme from TJS in Bodie Hills and the latite ignimbrite located east of Mono Lake reveal them both to be rhyolites with the latite ignimbrite sharing elevated K composition seen in the slightly younger Stanislaus Group (9.0 - 10.2 Ma). We establish a paleomagnetic reference direction of D = 352.8o I = 42.7o α95 = 7.7o n = 5 sites (42 samples) for TJS in the Bodie Hills in a region hypothesized by Carlson (2012) to have experienced low rotation. Our reference for Gilbert's latite ignimbrite (at Cowtrack Mountain) is D = 352.9o I = 32.1o α95 = 4.7o. This reference locality is found on basement highland likely to have experienced less deformation then the nearby Mono Basin since ignimbrite emplacement. Paleomagnetic results from this latite ignimbrite suggests ~98.2o × 5.5o of clockwise vertical axis rotation of parts of eastern Mono Basin since

  20. Synthesis of Mono-and Di-fluorinated Benzimidazoles

    Institute of Scientific and Technical Information of China (English)

    Liang Wu; Liu Gang

    2011-01-01

    Three efficient methods to synthesize mono-and di-fluofinated benzimidazoles are reported. These methods provide 5-amino-6-fluoro-benzimidazoles (5), 5,7-difluoro-benzimidazoles (10), and 6-fluoro-benzimidazoles (13) starting from commercially available 1,5-difluoro-2,4-dinitrobenzene (DFDNB), 2,3,4,5-tetrafluoro-6-nitrobenzoic acid (TFNBA), and 2,4-difluoro-l-aitrobenzene (DFNB), respectively.

  1. Postcolumn HPLC Detection of Mono- and Oligosaccharides with a Chemosensor

    Science.gov (United States)

    Kim, Kyu Kwang; Escobedo, Jorge O.; St. Luce, Nadia N.; Rusin, Oleksandr; Wong, Douglas; Strongin, Robert M.

    2012-01-01

    Novel chromophoric compound 1 promotes the HPLC postcolumn detection of mono- and oligosaccharides. The detection of chromatographic peaks in the visible region for glucose, fructose, maltodextrins, sialic acid, and a ganglioside can be accomplished with a standard UV–vis detector. The use of selective, reversible binding agents in automated HPLC assays should allow for improved monitoring of specific analytes as well as material recovery. PMID:14682751

  2. Electrical properties mono- and polycrystalline silicon solar cells

    OpenAIRE

    L.A. Dobrzański; M. Szczęsna; M. Szindler; A. Drygała

    2013-01-01

    Purpose: The goal of this article was to compare the properties of mono- and polycrystalline silicon solar cells. It was based on measurements performed of current-voltage characteristics and calculated parameters using mathematical formulas. Design/methodology/approach: Light and dark current-voltage characteristics of solar cells were measured using a solar simulator PV Test Solutions company SS150AAA model. The measurements were performed under standard conditions (Pin =...

  3. Volcanic Geology of Negit Island, Mono Lake, CA

    Science.gov (United States)

    Bursik, M.; Kobs, S.; Jayko, A.

    2008-12-01

    Negit Island, located in Mono Lake, eastern California, is a dacitic cumulodome with seven distinct lava flows emanating from at least four separate vent areas. Vent areas are dominated by en echelon northeast-trending fissures, indicating strong tectonic control. Neptunian(?) pyroclastic deposits on the north end of the island indicate an explosive subaqueous eruption early in island history. Northwestern shorelands, as well as a former landbridge to the island, retain a localized cap of rotated Pleistocene lake bottom sediment blocks, suggesting that proto-Negit was similar to modern Paoha Island, a nearby young structural dome draped with rotated lake bed blocks and explosive ejecta. In analogy with Paoha, the pyroclastic ejecta and blocks may thus indicate sublacustrine block landsliding with attendant eruption as an initial magmatic-structural dome grew, on which later lava domes and flows were superposed. What may be the oldest lava flow, in the center-west, is overlain by a deep orange-red soil, and three Mono Craters tephras. The well-developed soil indicates an extended period of chemical weathering before overlying tephra deposition. The southwestern end of the island is dominated by young lava flows and a prominent dome, which are not overlain by the most recent North Mono Craters tephra of 1350 A.D., consistent with earlier work indicating that parts of the island are younger than any eruption of the Mono Craters. The history of early structural doming with little or minimal eruptive activity at both Negit and Paoha Islands may have important implications for the current episode of noneruptive unrest and doming at nearby Long Valley caldera.

  4. Modification and performance evaluation of a mono-valve engine

    Science.gov (United States)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  5. Mono- versus polydrug abuse patterns among publicly funded clients

    Directory of Open Access Journals (Sweden)

    Relyea George

    2007-11-01

    Full Text Available Abstract To examine patterns of mono- versus polydrug abuse, data were obtained from intake records of 69,891 admissions to publicly funded treatment programs in Tennessee between 1998 and 2004. While descriptive statistics were employed to report frequency and patterns of mono- and polydrug abuse by demographic variables and by study years, bivariate logistic regression was applied to assess the probability of being a mono- or polydrug abuser for a number of demographic variables. The researchers found that during the study period 51.3% of admissions reported monodrug abuse and 48.7% reported polydrug abuse. Alcohol, cocaine, and marijuana were the most commonly abused substances, both alone and in combination. Odds ratio favored polydrug abuse for all but one drug category–other drugs. Gender did not affect drug abuse patterns; however, admissions for African Americans and those living in urban areas exhibited higher probabilities of polydrug abuse. Age group also appeared to affect drug abuse patterns, with higher odds of monodrug abuse among minors and adults over 45 years old. The discernable prevalence of polydrug abuse suggests a need for developing effective prevention strategies and treatment plans specific to polydrug abuse.

  6. Nongeocentric axial dipole field behavior during the Mono Lake excursion

    Science.gov (United States)

    Negrini, Robert M.; McCuan, Daniel T.; Horton, Robert A.; Lopez, James D.; Cassata, William S.; Channell, James E. T.; Verosub, Kenneth L.; Knott, Jeffrey R.; Coe, Robert S.; Liddicoat, Joseph C.; Lund, Steven P.; Benson, Larry V.; Sarna-Wojcicki, Andrei M.

    2014-04-01

    A new record of the Mono Lake excursion (MLE) is reported from the Summer Lake Basin of Oregon, USA. Sediment magnetic properties indicate magnetite as the magnetization carrier and imply suitability of the sediments as accurate recorders of the magnetic field including relative paleointensity (RPI) variations. The magnitudes and phases of the declination, inclination, and RPI components of the new record correlate well with other coeval but lower resolution records from western North America including records from the Wilson Creek Formation exposed around Mono Lake. The virtual geomagnetic pole (VGP) path of the new record is similar to that from another high-resolution record of the MLE from Ocean Drilling Program (ODP) Site 919 in the Irminger Basin between Iceland and Greenland but different from the VGP path for the Laschamp excursion (LE), including that found lower in the ODP-919 core. Thus, the prominent excursion recorded at Mono Lake, California, is not the LE but rather one that is several thousands of years younger. The MLE VGP path contains clusters, the locations of which coincide with nonaxial dipole features found in the Holocene geomagnetic field. The clusters are occupied in the same time progression by VGPs from Summer Lake and the Irminger Basin, but the phase of occupation is offset, a behavior that suggests time-transgressive decay and return of the principal field components at the beginning and end of the MLE, respectively, leaving the nonaxial dipole features associated with the clusters dominant during the excursion.

  7. Age of the Mono Lake excursion and associated tephra

    Science.gov (United States)

    Benson, Larry; Liddicoat, Joseph; Smoot, Joseph; Sarna-Wojcicki, Andrei; Negrini, Robert; Lund, Steve

    2003-02-01

    The Mono Lake excursion (MLE) is an important time marker that has been found in lake and marine sediments across much of the Northern Hemisphere. Dating of this event at its type locality, the Mono Basin of California, has yielded controversial results with the most recent effort concluding that the MLE may actually be the Laschamp excursion (Earth Planet. Sci. Lett. 197 (2002) 151). We show that a volcanic tephra (Ash ♯15) that occurs near the midpoint of the MLE has a date (not corrected for reservoir effect) of 28,620±300 14C yr BP (˜32,400 GISP2 yr BP) in the Pyramid Lake Basin of Nevada. Given the location of Ash ♯15 and the duration of the MLE in the Mono Basin, the event occurred between 31,500 and 33,300 GISP2 yr BP, an age range consistent with the position and age of the uppermost of two paleointensity minima in the NAPIS-75 stack that has been associated with the MLE (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009). The lower paleointensity minimum in the NAPIS-75 stack is considered to be the Laschamp excursion (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009).

  8. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Directory of Open Access Journals (Sweden)

    Chunping Liu

    Full Text Available Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE, whereas it has a scattered and patchy distribution in South China (SC. In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM. Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278 among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  9. Gamma spectra pictures using a digital plotter. Program MONO; Representacion de Espectros directos mediante un trazado digital. Prograa MONO

    Energy Technology Data Exchange (ETDEWEB)

    Los Arcos, J. M.

    1978-07-01

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs.

  10. The relationship between mono-abundance and mono-age stellar populations in the Milky Way disk

    CERN Document Server

    Minchev, I; Chiappini, C; Martig, M; Anders, F; Matijevic, G; de Jong, R S

    2016-01-01

    Studying the Milky Way disk structure using stars in narrow bins of [Fe/H] and [alpha/Fe] has recently been proposed as a powerful method to understand the Galactic thick and thin disk formation. It has been assumed so far that these mono-abundance populations (MAPs) are also coeval, or mono-age, populations. Here we study this relationship for a Milky Way chemo-dynamical model and show that equivalence between MAPs and mono-age populations exists only for the high-[alpha/Fe] tail, where the chemical evolution curves of different Galactic radii are far apart. At lower [alpha/Fe]-values a MAP is composed of stars with a range in ages, even for small observational uncertainties and a small MAP bin size. Due to the disk inside-out formation, for these MAPs younger stars are typically located at larger radii, which results in negative radial age gradients that can be as large as 2 Gyr/kpc. Positive radial age gradients can result for MAPs at the lowest [alpha/Fe] and highest [Fe/H] end. Such variations with age p...

  11. Prevalencia de hiperlipidemia e hiperglicemia en niños obesos: ¿riesgo aumentado de enfermedad cardiovascular? Hyperlipidemia and hyperglycemia prevalence in obese children: increased risk of cardiovascular disease?

    Directory of Open Access Journals (Sweden)

    M. Marcano

    2006-08-01

    Full Text Available Las enfermedades cardiovasculares representan la primera causa de muerte en Venezuela desde el año 1967. Existen evidencias que demuestran que la lesión temprana de la aterosclerosis coronaria se inicia en la infancia con marcada asociación a la obesidad y diabetes, por lo que su prevención debe iniciarse en esa época. Objetivo: Estudiar la presencia de hiperlipidemia e hiperglicemia en niños obesos como indicadores de riesgo. Metodología: Se seleccionaron 121 niños (edad 8,7±3,43 años, con índice de masa corporal mayor al P90 para su edad (Fundacredesa. Se determinó colesterol sérico total y fracciones (HDL-C y LDL-C, triglicéridos y glicemia en ayunas por métodos enzimáticos-colorimétricos.Se utilizaron puntos de corte para colesterol y triglicéridos según referencia nacional (Fundacredesa, para las LDL-C y HDL-C, los criterios del National Cholesterol Education Program y para glicemia según la American Diabetes Association. La muestra se agrupó por edad en: 2-5,11 años (19%: Grupo 1; 6-8,11 años (28,1%: Grupo 2 y mayores de 9 años (52,9%: Grupo 3. Análisis estadístico por genero y grupo etario. Resultados: El colesterol se ubicó en "riesgo" en los varones Grupo 1. Las HDL-C en riesgo en las niñas de Grupo 1 y Grupo 3 y en los varones Grupo 3. Los triglicéridos, se ubicaron en niveles de "riesgo" para las niñas Grupo 1 y Grupo 3 y varones Grupo 2 y en rango "elevado" en los varones Grupo 1 y Grupo 3. Las LDL-C, se ubicaron en todos los grupos en rango "aceptable" y no se encontró hiperglicemia en los niños evaluados. Conclusión: El perfil bajo de HDL y elevado de triglicéridos, sugiere un mayor riesgo de estos niños obesos a enfermedad cardiovascular, con mayor afectación en el género masculino. Una elevada proporción de ellos cumple con tres criterios definitorios de Síndrome metabólico por lo que se recomienda control dietario y modificaciones en el patrón de alimentación y de actividad f

  12. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: Update. Consensus SEMICYUC-SENPE: Obese patient Recomendaciones para el soporte nutricional y metabólico especializado del paciente crítico: Actualización. Consenso SEMICYUC-SENPE: Paciente obeso

    Directory of Open Access Journals (Sweden)

    A. Mesejo

    2011-11-01

    exercised when interpreting these data.El paciente obeso crítico, como respuesta al estrés metabólico, tiene igual riesgo de depleción nutricional que el paciente no obeso, pudiendo desarrollar una malnutrición energeticoproteica,con una acelerada degradación de masa muscular. El primer objetivo del soporte nutricional en estos pacientes debe ser minimizar la pérdida de masa magra y realizar una evaluación adecuada del gasto energético. Sin embargo, la aplicación de las fórmulas habituales para el cálculo de las necesidades calóricas puede sobrestimarlas si se utiliza el peso real, por lo que sería más correcto su aplicación con el peso ajustado o el peso ideal, aunque la alorimetría indirecta es el método de elección. La controversia se centra en si hay que aplicar un criterio estricto de soporte nutricional ajustado a los requerimientos o se aplica un cierto grado de hiponutrición permisiva. La evidencia actual sugiere que la nutrición hipocalórica puede mejorar los resultados, en parte debido a una menor tasa de complicaciones infecciosas y a un mejor control de la hiperglucemia, por lo que la nutrición hipocalórica e hiperproteica, tanto enteral como parenteral, debe ser la práctica estándar en el soporte nutricional del paciente obeso crítico si no hay contraindicaciones para ello. Las recomendaciones generalmente admitidas se centran en no exceder el 60-70% de los requerimientos o administrar 11-14 o 22-25 kcal/kg peso ideal/día, con 2-2,5 g/kg peso ideal/día de proteínas. En sentido amplio puede considerarse la nutrición hipocalórica-hiperproteica como específica del paciente obeso crítico, aunque las complicaciones ligadas a su comorbilidad hace que se planteen otras posibilidades terapéuticas, con nutrientes específicos para hiperglucemia, síndrome del distrés respiratorio agudo (SDRA y sepsis. Sin embargo, no existe ningún estudio prospectivo y aleatorio con este tipo de nutrientes en este subgrupo concreto de población y

  13. Uric acid is associated with features of insulin resistance syndrome in obese children at prepubertal stage El ácido úrico se asocia con características de un síndrome de resistencia insulínica en los niños obesos en etapas prepuberales

    Directory of Open Access Journals (Sweden)

    M. Gil-Campos

    2009-10-01

    ingesta dietética y los parámetros asociados al síndrome de resistencia insulínica. El estudio se llevó a cabo en 34 niños obesos y 20 controles en edad prepuberal a los cuales se les estimó su ingesta dietética mediante el registro de un cuestionario de ingesta de alimentos de 72 h y un cuestionario de frecuencia de consumo de alimentos y se determinaron, además de los parámetros antropométricos, la glucosa, la insulina, la leptina, la adiponectina y el factor de necrosis tumoral alfa (TNF-α plasmáticos. Se realizó un análisis de regresión múltiple para identificar la asociación entre los niveles de ácido úrico y los parámetros antropométricos, la ingesta de nutrientes y las variables clásicas relacionadas con el síndrome de resistencia insulínica (hipertensión, glucosa, insulina, índice de resistencia insulínica HOMA, triglicéridos y HDL-colesterol plasmáticos, así como con leptina, adiponectina y TNF-α. La concentración plasmática de ácido úrico fue significativamente más elevada en los niños obesos que en los controles y, cuando se ajustó por sexo, edad e índice de masa corporal, los niveles de ácido úrico se asociaron con el pliegue tricipital y la resistencia inulínica, y negativamente con la adiponectina. En el análisis de regresión múltiple, el índice de masa corporal, el HDL-colesterol y la adiponectina fueron predictores independientes del ácido úrico plasmático. En conclusión, los niveles elevados de ácido úrico en niños obesos en edad prepuberal, comparado con los de los niños normales, representan una alteración metabólica temprana asociada con la resistencia insulínica.

  14. Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients Ensayo clínico aletorizado doble ciego controlado con placebo con una galleta enriquecida en ácido alfa linoleico y prebióticos en el patrón de riesgo cardiovascular de pacientes obesos

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2011-08-01

    Full Text Available Introduction: Inulin and FOS are prebiotics with potential benefit in cardiovascular risk factors. Alpha linolenic acid (ALA is the metabolic precursor of the long chain n-3 fatty acid eicosapentaenoic acid (20: 5n-3, this fatty acid has anti-inflammatory properties. The aim of our study was to evaluate the response of the cardiovascular risk profile in obese patients after inclusion in the diet of an ALA, FOS and inulin enriched-cookie. Material and methods: 36 patients were randomized in both branches: group I (inulin, FOS and ALA enriched cookie Gullon SL® and group II (control cookie. Previous and after 1 month of the treatment, a nutritional and biochemical study was realized. Results: 15 patients finished the procotol in each group. In group I, a significantly increase in soluble fiber (2.3 ± 0.8 g/day vs 7.7 ± 0.8 g/day: p Introducción: La inulina y los FOS son prebióticos con potenciales efectos beneficiosos a nivel cardiovascular. El acido alfa linolénico (ALA es el precursor del ácido eicosapentaenoico (20: 5n-3, presentando propiedades antinflamatorias. El objetivo de nuestro trabajo es evaluar la respuesta del perfil de riesgo cardiovascular en pacientes obesos tras la inclusión en la dieta de una galleta enriquecida en inulina, FOS y ALA. Material y métodos: Un total de 36 pacientes fueron randomizados a una de las siguientes ramas: galleta I (enriquecida con inulina, FOS y ALA y galleta II (galleta control (Gullón SL. Cada paciente recibió un total de 2 galletas al día (70 gramos de producto. Antes de iniciar el tratamiento y al mes, se realizó una valoración nutricional y analítica. Resultados: Finalizaron el protocolo un total de 15 pacientes en cada grupo. En el grupo I se produjo un aumento significativo en la ingesta de fibra soluble (2,3 ± 0,8 g/día vs 7,7 ± 0,8 g/día: p < 0,05 (inulina y FOS, así como ALA (0,6 ± 0,5 g/día vs 3,8 ± 0,5 g/día; p < 0,05. Se detectó en los pacientes varones que

  15. Mono- and bis-thiazolium salts have potent antimalarial activity.

    Science.gov (United States)

    Hamzé, Abdallah; Rubi, Eric; Arnal, Pascal; Boisbrun, Michel; Carcel, Carole; Salom-Roig, Xavier; Maynadier, Marjorie; Wein, Sharon; Vial, Henri; Calas, Michèle

    2005-05-19

    Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC(50) values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED(50)

  16. iOS Development using MonoTouch Cookbook

    CERN Document Server

    Tavlikos, Dimitris

    2011-01-01

    The book is written in a cookbook style, presenting examples in the style of recipes, allowing you to go directly to your topic of interest, or follow topics throughout a chapter to gain in-depth knowledge. This book is essential for C# and .NET developers with no previous experience in iOS development and Objective-C developers that want to make a transition to the benefits of MonoTouch and the C# language, for creating complete, compelling iPhone, iPod and iPad applications and deploying them to the App Store.

  17. Mono-Z dark matter search with the ATLAS detector

    CERN Document Server

    Basalaev, Artem; The ATLAS collaboration

    2016-01-01

    A search with ATLAS detector is presented for collider signatures of weakly interacting dark matter particles (WIMPs) leading to mono-Z signal. Events with large missing transverse momentum and two oppositely-charged electrons or muons consistent with the decay of a Z-boson were selected in analysis. The limits on the mass scale of the contact interaction as a function of the dark matter particle mass and the limits on the coupling and scalar particle mediator obtained from Run 1 ATLAS data are shown. Analysis techniques specific to Run 2 are reviewed.

  18. Mono-Higgs signature in fermionic dark matter model

    OpenAIRE

    Ghorbani, Karim; Khalkhali, Leila

    2016-01-01

    In light of Higgs boson discovery, we explore mono-Higgs signature in association with dark matter pair production at the LHC. For two channels with $\\gamma\\gamma+\\text{MET}$ and $b \\bar b+\\text{MET}$ in the final state we simulate the SM backgrounds and signal events at $\\sqrt{s} = 14$ TeV. We then estimate the LHC sensitivities for various benchmark points for two integrated luminosities ${\\cal L} = 300~\\text{fb}^{-1}$ and ${\\cal L} = 3~ \\text{ab}^{-1}$. We constrain the Yukawa coupling of ...

  19. Consumo de productos alimenticios dietéticos en niños diabéticos y obesos.

    OpenAIRE

    Borrello, Carolina

    2009-01-01

    Los seres humanos nacen con la preferencia hacia el sabor dulce y en ciertas ocasiones es necesario limitar el consumo de azúcares como en el control de peso, en prevención de caries o en personas diabéticas, para estos casos la industria ofrece una variedad de edulcorantes y productos dietéticos endulzados con ellos. Las tendencias actuales en la alimentación, llevan al hombre a un mayor consumo de alimentos concentrados en azúcares refinados y grasas, siendo la obesidad, c...

  20. Effectiveness of oxybutynin for treatment of hyperhidrosis in overweight and obese patients Eficácia da oxibutina no tratamento de hiperidrose em pacientes com sobrepeso e obesos

    Directory of Open Access Journals (Sweden)

    Nelson Wolosker

    2013-04-01

    Full Text Available OBJECTIVE: Until the present moment, the lack of efficient therapeutic options available for hyperhidrosis treatment in obese patients has left this population without prospect of clinical or quality of life (QOL improvements. Outcomes of oxybutynin treatment for overweight and obese patients with hyperhidrosis are unknown. This study aims to investigate the results related to clinical and QOL improvements in this specific population, submitted to a 12-week protocol treatment with oxybutynin. METHODS: 559 patients with palmar and axillary hyperhidrosis, routinely followed in this service, were divided into the groups, according to their body mass index (BMI ( 30 kg/m². Improvements in QOL and in the level of hyperhidrosis were analyzed after 12 weeks of protocol treatment with oxybutynin. These parameters were investigated using a scoring system based on a scientifically validated clinical questionnaire, applied before and after treatment. RESULTS: 67.8% of the overweight sample group and 63% of the obese patients presented "partial" or "great" improvement in the level of hyperhidrosis. Over 65% of patients demonstrated improvement in QOL ("much better" or "slightly better" for all three groups, with no statistical difference between them. The only adverse event associated with oxybutynin was dry mouth, observed in 63.0% of the patients. CONCLUSION: Overweight and obese patients with palmar or axillary hyperhidrosis present significant improvement in QOL after treatment with oxybutynin, and the results are comparable to those of normal weight individuals.OBJETIVO: A falta de alternativas terapêuticas para o tratamento de pacientes obesos com Hiperidrose hiperidrose deixa essa população sem perspectiva de melhorar suas condições clínicas e qualidade de vida. Resultados do tratamento com oxibutinina especificamenteempacientes com sobrepeso ou obesidade são desconhecidos até o presente momento. Este estudo tem como objetivo investigar os

  1. Beneficios de la terapia cognitivo-conductual y la presoterapia en pacientes obesos: ensayo clínico aleatorizado Benefits of cognitive behavior therapy and acupressure therapy in obese patients: a randomized clinical trial

    OpenAIRE

    Torres, V; A. Mª Castro Sánchez; G. A. Matarán Peñarocha; I. Lara Palomo; Mª E. Aguilar Ferrándiz; C. Moreno Lorenzo

    2011-01-01

    Objetivo: el objetivo del presente trabajo fue analizar la modificación de los hábitos de vida en pacientes obesos mediante la terapia cognitivo-conductual administrada conjuntamente con la presoterapia. Métodos: Se realizó un estudio experimental con grupo control placebo. Se asignaron de forma aleatoria 40 pacientes a grupo de intervención (terapia cognitivo-conductual + presoterapia) y a grupo control (sesiones informativas). La dimensión de estudio fue la administración de un cuestionario...

  2. Ensayo clínico aleatorizado con una galleta enriquecida en inulina en el patrón de riesgo cardiovascular de pacientes obesos Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients

    OpenAIRE

    D. A. De Luis; B. de la Fuente; O. Izaola; Conde, R.; S. Gutiérrez; Morillo, M.; C. Teba Torres

    2010-01-01

    Introducción: La inulina es un prebiótico con potenciales efectos beneficiosos a nivel cardiovascular. El objetivo de nuestro trabajo es evaluar la respuesta del perfil de riesgo cardiovascular en pacientes obesos tras la inclusión en la dieta de una galleta enriquecida en inulina. Material y métodos: Un total de 34 pacientes fueron randomizados a una de las siguientes ramas: galleta I (enriquecida con inulina, ver tabla I) y galleta II (galleta control, ver tabla I) (Gullón SL). Cada pacient...

  3. Mono-W Dark Matter Signals at the LHC: Simplified Model Analysis

    CERN Document Server

    Bell, Nicole F; Leane, Rebecca K

    2015-01-01

    We study mono-W signals of dark matter (DM) production at the LHC, in the context of gauge invariant renormalizable models. We analyze two simplified models, one involving an s-channel Z' mediator and the other a t-channel colored scalar mediator, and consider examples in which the DM-quark couplings are either isospin conserving or isospin violating after electroweak symmetry breaking. While previous work on mono-W signals have focused on isospin violating EFTs, obtaining very strong limits, we find that isospin violating effects are small once such physics is embedded into a gauge invariant simplified model. We thus find that the 8 TeV mono-W results are much less constraining than those arising from mono-jet searches. Considering both the leptonic (mono-lepton) and hadronic (mono fat jet) decays of the W, we determine the 14 TeV LHC reach of the mono-W searches with 3000 fb$^{-1}$ of data. While a mono-W signal would provide an important complement to a mono-jet discovery channel, existing constraints on t...

  4. MonoSLAM: real-time single camera SLAM.

    Science.gov (United States)

    Davison, Andrew J; Reid, Ian D; Molton, Nicholas D; Stasse, Olivier

    2007-06-01

    We present a real-time algorithm which can recover the 3D trajectory of a monocular camera, moving rapidly through a previously unknown scene. Our system, which we dub MonoSLAM, is the first successful application of the SLAM methodology from mobile robotics to the "pure vision" domain of a single uncontrolled camera, achieving real time but drift-free performance inaccessible to Structure from Motion approaches. The core of the approach is the online creation of a sparse but persistent map of natural landmarks within a probabilistic framework. Our key novel contributions include an active approach to mapping and measurement, the use of a general motion model for smooth camera movement, and solutions for monocular feature initialization and feature orientation estimation. Together, these add up to an extremely efficient and robust algorithm which runs at 30 Hz with standard PC and camera hardware. This work extends the range of robotic systems in which SLAM can be usefully applied, but also opens up new areas. We present applications of MonoSLAM to real-time 3D localization and mapping for a high-performance full-size humanoid robot and live augmented reality with a hand-held camera. PMID:17431302

  5. Steroid Derived Mesoionic Gold and Silver Mono- and Polymetallic Carbenes.

    Science.gov (United States)

    Frutos, María; de la Torre, María C; Sierra, Miguel A

    2015-12-01

    A two-step synthesis of gold mesoionic carbene complexes containing estrone moieties has been developed. The method uses the methylation of the triazole nucleus, followed by the treatment of the triazolium salt with Ag2O and transmetalation with [AuCl(SMe2)]. Mono-, bi-, tri-, and tetrametallic gold complexes can be obtained depending on the structure of the starting triazolium salts. Tetrametallic gold carbene embedded in a macrocylic stereoidal cavity containing four estrone nuclei has been also prepared. Additionally, the mono- and bimetallic silver carbene complexes containing triazole-steroid ligands have been isolated and characterized. These complexes resulted to be stable and have been characterized by spectroscopic and HRMS techniques. The gold and silver complexes having triazole-steroid ligands are unprecedented in the literature and the method reported here to access to these compounds is easy and efficient. Preliminary results regarding the catalytic activity of some of the gold-carbenes prepared in the insertion of diazoalkanes into alcohols are presented. PMID:26600185

  6. Crenças e influências sobre dietas de emagrecimento entre obesos de baixa renda Beliefs and influences on weight loss diets among low-income obese individuals

    Directory of Open Access Journals (Sweden)

    Ana Paula Rodrigues Cavalcanti

    2007-12-01

    Full Text Available A obesidade tornou-se uma epidemia carente de controle imediato, principalmente entre pobres, mulheres e pessoas de baixa escolaridade. A OMS solicita e vários estudos corroboram que estudos esclarecedores sobre os comportamentos psicológicos e sociais interferentes na aderência terapêutica aos regimes devem ser encorajados. Este estudo usou a Teoria da Ação Racional - TAR, de M. Fishbein, em Psicologia Social, e comparou duas séries de entrevistas abertas (em 2001 e 2005 que eliciaram as crenças positivas (vantagens e negativas (desvantagens sobre fazer dieta entre obesos de baixa renda de João Pessoa, Paraíba, além dos referentes (pessoas de opinião influente destes pacientes quanto a segui-la. Os resultados de 2001 foram corroborados em 2005, revelando o medo das doenças relacionadas à obesidade e a vontade de sentir mais saúde e leveza de corpo. Mães, filhos e principalmente o cônjuge aparecem como apoiadores do regime. Ressaltou-se que não bastaria força de vontade, mas também reflexão e construção de habilidades de controle, apropriação e modificação das condições de vida. Preocupações estéticas não foram prioritárias. Estas informações podem fomentar melhores resultados na aderência terapêutica.Obesity has become an epidemic that requires immediate control, mainly among the poor, particularly women and the less educated. The WHO requests and several studies confirm that support is needed for research projects examining psychological and social behavior that hampers compliance with weight loss diets. This paper uses the Theory of Reasoned Action (TRA of M. Fishbein (1975 in social psychology, comparing two series of open interviews (conducted in 2001 and 2005 that disclosed positive (advantageous and negative (harmful beliefs about weight loss diets among low-income obese patients in João Pessoa, Paraíba State, as well as their guides (people of influential opinion on following their diets. The 2001

  7. On the generation of mono-implicit Runge-Kutta-Nyström methods by mono-implicit Runge-Kutta methods

    OpenAIRE

    de Meyer, Hans; Vanden Berghe, Guido; Van Hecke, Tanja; Van Daele, Marnix

    1997-01-01

    Mono-implicit Runge-Kutta methods can be used to generate implicit Runge-Kutta-Nystrom (IRKN) methods for the numerical solution of systems of second-order differential equations. The paper is concerned with the investigation of the conditions to be fulfilled by the mono-implicit Runge-Kutta (MIRK) method in order to generate a mono-implicit Runge-Kutta-Nystrom method (MIRKN) that is P-stable. One of the main theoretical results is the property that MIRK methods (in standard form) cannot gene...

  8. Evaluación inmunológica de proteínas recombinantes de fusión de dengue 1 y dengue 2 en monos

    OpenAIRE

    Bernardo Reyes, Lídice

    2010-01-01

    El desarrollo de subunidades recombinantes que contienen al dominio III de la proteína de la envoltura (E) de los virus del dengue (DEN) es una alternativa para el desarrollo de una vacuna segura contra esta entidad. En este trabajo caracterizamos la respuesta inmune inducida en monos por proteínas recombinantes de fusión de DEN 1 y DEN 2 que contienen al dominio III de la proteína E fusionado a la proteína P64k de Neisseria meningitidis. Se demostró que la proteína recombinante P64k-domin...

  9. Rare earth element and uranium-thorium variations in tufa deposits from the Mono Basin, CA

    Science.gov (United States)

    Wilcox, E. S.; Tomascak, P. B.; Hemming, N.; Hemming, S. R.; Rasbury, T.; Stine, S.; Zimmerman, S. R.

    2009-12-01

    Samples of fossil tufa deposits from several localities in the Mono Basin, eastern California, were analyzed for trace element concentrations in order to better understand changes in lake composition in the past. These deposits were formed during the last glacial cycle, mostly during deglaciation (Benson et al., 1990, PPP). Three elevations are represented by the analyses. Samples from near Highway 167 were sampled between 2063 and 2069 m asl. Samples from near Thompson Road were sampled between 2015 and 2021 m. One layered mound was sampled at 1955 m. Concentrations of the lanthanide rare earth elements (REE), in particular the heavy/light (HREE/LREE) distributions, have been shown to be sensitive to alkalinity in modern saline lakes (e.g., Johannesson et al., 1994, GRL, 21, 773-776), and the same has been suggested for U/Th (Anderson et al., 1982, Science, 216, 514-516). Holocene to near-modern tufa towers exist in shallow water and around the current shoreline (1945 m). Tufa towers above 2000 m include a characteristic morphology termed thinolite, interpreted to represent pseudomorphs after the very cold water mineral ikaite. Most lower elevation towers do not have the thinolite morphology, but some layered tufa mounds at low elevations include several layers of thinolite, such as the one sampled for this project. Analyses were made on millimeter-scale bulk samples from tufa towers. Measurements were made on sample solutions with a Varian 820MS quadrupole ICP-MS. Mono Basin tufa samples have total REE concentrations ranging from 0.029 to 0.77 times average shales. Samples have flat to moderately HREE-enriched shale-normalized patterns with limited overall variability ([La/Lu]SN of 1.8 to 9.6) but with some variability in the slope of the HREE portion of the patterns. Tufa towers sampled from three elevations have (Gd/Lu)SN of 0.40 to 1.5. The REE patterns of most samples have small positive Ce anomalies, but a minority of samples, all from the layered tufa mound

  10. Three-dimensional model of the Mono Basin (California): finite element analysis of the interaction between the Hartley Spring Fault and the Mono Dike

    Science.gov (United States)

    La Marra, D.; Manconi, A.; McDonnell, A.; Battaglia, M.

    2012-12-01

    Mono Basin is a northward-trending structural depression lying immediately east of the central Sierra Nevada (California) that extends from the northern edge of Long Valley Caldera towards the center of Mono Lake. The Mono-Inyo Craters volcanic chain forms a prominent 17-km-long arcuate ridge within the Mono Basin. Recent studies have proposed that the volcanism and tectonism in this area is likely interrelated. Stratigraphic data suggest that a series of strong earthquakes occurred during the North Mono-Inyo eruption sequence of 1350 A.D. Geological data are consistent with rupture of the Hartley Springs fault during the eruption sequence. The temporal proximity of these events suggests the possibility of a causal relationship. We use the Finite Element Method (FEM) to generate a three-dimensional model of the Mono Basin and investigate the feedback mechanism between dike intrusion and slip along the Hartley Springs fault. First we combine the potential of the FEM with the Okada (1992) analytical solution for a homogeneous elastic flat half-space to validate our model. Then, to better simulate a geodynamic model of the Mono Basin, we implement more realistic dynamics that include gravity forces, vertical and lateral heterogeneities of the crust, and topography. We evaluate the distribution of local stress changes to study the influence of the Inyo dike intrusion on the Hartley Springs fault and how slip along the fault may encourage the propagation of dikes towards the surface. We employ the Coulomb stress change as a failure criterion on the Hartley Springs fault. Preliminary results indicate that slip along the Hartley Springs fault may have encouraged the intrusion of the Mono Dike.

  11. P ET CO2 e SpO2 permitem ajuste ventilatório adequado em pacientes obesos mórbidos P ET CO2 y SpO2 permiten ajuste de ventilación adecuada en pacientes obesos mórbidos P ET CO2 and SpO2 allow adequate ventilatory adjustment in morbidly obese patients

    Directory of Open Access Journals (Sweden)

    Fábio Ely Martins Benseñor

    2004-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar das diversas propostas ventilatórias para anestesia em pacientes obesos mórbidos, um consenso não foi estabelecido. Este estudo avaliou o ajuste ventilatório nestes pacientes durante anestesia baseado na oximetria e capnografia. MÉTODO: O consentimento prévio foi obtido da Comissão de Ética e dos pacientes. Excluíram-se tabagistas e portadores de doença cardíaca ou pulmonar. Foram estudados 11 pacientes com índice de massa corpórea (IMC de 59,2 ± 8,3 submetidos à gastroplastia sob anestesia geral (Grupo O. Oito não-obesos (IMC 20,2 ± 3,9 submetidos à gastrectomia formaram o grupo controle (NO. Ajustou-se a ventilação visando dióxido de carbono expiratório final (P ET CO2 menor que 40 mmHg e saturação periférica de oxigênio (SpO2 maior que 95%. Não se utilizou PEEP. Através de monitor respiratório CO2SMO Plus, mediu-se espaços mortos fisiológico, alveolar e de vias aéreas (VD phy, VD alv e VD aw e o volume corrente alveolar (VT alv. Amostras de sangue arterial e venoso central permitiram calcular PaO2/FIO2 e VD phy/VT. Os dados foram comparados e analisados por ANOVA (p JUSTIFICATIVA Y OBJETIVOS: A pesar de las diversas propuestas de ventilación para anestesia en pacientes obesos mórbidos, un consenso no fue establecido. Este estudio evaluó el ajuste de ventilación en estos pacientes durante anestesia fundamentado en la oximetria y capnografia. MÉTODO: El consentimiento previo fue obtenido de la Comisión de Ética y de los pacientes. Fueron excluidos fumantes y portadores de enfermedad cardíaca o pulmonar. Fueron estudiados once pacientes con índice de masa corpórea (IMC de 59,2 ± 8,3 sometidos a gastroplastia bajo anestesia general (Grupo O. Ocho no obesos (IMC 20,2 ± 3,9 sometidos a gastrectomia formaron el grupo control (NO. Se ajustó la ventilación visando el dióxido de carbono expiratorio final (P ET CO2 menor que 40 mmHg y saturación periférica de oxígeno (Sp

  12. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial Alteraciones vasculares en ratones obesos por dieta rica en grasa: papel de la vía L-arginina/NO endotelial Vascular alterations in high-fat diet-obese rats: role of Endothelial L-arginine/NO Pathway

    Directory of Open Access Journals (Sweden)

    Thiago Bruder Nascimento

    2011-07-01

    Full Text Available FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C e obeso (OB, ratos sob dieta rica em gordura por 30 semanas. Após 30 semanas, foram registrados o peso corporal, índice de adiposidade, pressão arterial e perfis metabólicos e endócrinos dos animais. Foram obtidas curvas para noradrelanina na ausência e presença de inibidor de óxido nítrico sintase (L-NAME, 3x10-4M em aorta torácica intacta e com desnudamento em ratos C e OB. RESULTADOS: As medidas de peso corporal, índice de adiposidade, leptina e insulina aumentaram nos ratos OB, enquanto a pressão arterial permaneceu inalterada. A obesidade também produziu tolerância à glicose e resistência à insulina. A reatividade à noradrenalina da aorta intacta foi similar em ratos C e OB. A presença de L-NAME produziu um aumento similar nas respostas máximas, mas um desvio maior à esquerda das respostas nas aortas intactas dos ratos C em relação aos ratos OB [EC50 (x10-7M: C = 1,84 (0,83-4,07, O = 2,49 (1,41-4,38; presença de L-NAME C = 0,02 (0,01-0,04*, O = 0,21 (0,11-0,40*†,*p FUNDAMENTO: Los mecanismos subyacentes a las anormalidades vasculares en la obesidad todavía no están completamente aclarados. OBJETIVO: Se evaluó la vía del óxido nítrico/L-arginina en la respuesta vascular de ratones obesos por dieta rica en grasa, concentrándonos en las células endoteliales y en el músculo liso. MÉTODOS: Ratones con 30 días de vida que fueron divididos en 2 grupos: control (C y obeso (OB, ratones bajo dieta rica en grasa durante 30 semanas. Después de 30 semanas, fueron registrados el peso corporal, el índice de adiposidad, la presión arterial y los

  13. Mechanically flexible optically transparent porous mono-crystalline silicon substrate

    KAUST Repository

    Rojas, Jhonathan Prieto

    2012-01-01

    For the first time, we present a simple process to fabricate a thin (≥5μm), mechanically flexible, optically transparent, porous mono-crystalline silicon substrate. Relying only on reactive ion etching steps, we are able to controllably peel off a thin layer of the original substrate. This scheme is cost favorable as it uses a low-cost silicon <100> wafer and furthermore it has the potential for recycling the remaining part of the wafer that otherwise would be lost and wasted during conventional back-grinding process. Due to its porosity, it shows see-through transparency and potential for flexible membrane applications, neural probing and such. Our process can offer flexible, transparent silicon from post high-thermal budget processed device wafer to retain the high performance electronics on flexible substrates. © 2012 IEEE.

  14. Mono-jet Signatures of Gluphilic Scalar Dark Matter

    CERN Document Server

    Godbole, Rohini M; Shivaji, Ambresh; Tait, Tim M P

    2016-01-01

    A gluphilic scalar dark matter (GSDM) model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum ("mono-jet") in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT) treatment, and find (as expected) that EFT does not accurately describe regions of parameter space where mass of the colored mediator particles are comparable to the experimental cuts on the missing energy. We determine bounds (for several choices of SU(3) representation of the mediator) from the $\\sqrt{s}=$ 8 TeV data, and show the expected reach of the $\\sqrt{s}=$ 13 TeV LHC and a future 100 TeV $pp$ collider to constrain or discover GSDM models.

  15. Mono-Higgs Detection of Dark Matter at the LHC

    CERN Document Server

    Berlin, Asher; Wang, Lian-Tao

    2014-01-01

    Motivated by the recent discovery of the Higgs boson, we investigate the possibility that a missing energy plus Higgs final state is the dominant signal channel for dark matter at the LHC. We consider examples of higher-dimension operators where a Higgs and dark matter pair are produced through an off-shell Z or photon, finding potential sensitivity at the LHC to cutoff scales of around a few hundred GeV. We generalize this production mechanism to a simplified model by introducing a Z' as well as a second Higgs doublet, where the pseudoscalar couples to dark matter. Resonant production of the Z' which decays to a Higgs plus invisible particles gives rise to a potential mono-Higgs signal. This may be observable at the 14 TeV LHC at low tan beta and when the Z' mass is roughly in the range 600 GeV to 1.3 TeV.

  16. Aryl hydrocarbon mono-oxygenase activity in human lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, G.D.; Schuresko, D.D.

    1981-06-01

    Aryl hydrocarbon mono-oxygenase (AHM), an enzyme of key importance in metabolism of xenobiotic chemicals such as polynuclear aromatic hydrocarbons (PNA), is present in human lymphocytes. Studies investing the relation of activity of AHM in human lymphocytes to parameters such as disease state, PNA exposure, in vitro mitogen stimulation, etc. have been summarized in this report. Some studies have demonstrated increased AHM activity in lymphocytes from cigarette smokers (compared to nonsmokers), and in lung cancer patients when compared to appropriate control groups. These observations are confused by extreme variability in human lymphocyte AHM activities, such variability arising from factors such as genetic variation in AHM activity, variation in in vitro culture conditions which affect AHM activity, and the problematical relationship of common AHM assays to actual PNA metabolism taking place in lymphocytes. If some of the foregoing problems can be adequately addressed, lymphocyte AHM activity could hold the promise of being a useful biomarker system for human PNA exposure.

  17. Fatigue Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability as well as systems reliability is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...... is investigated. The systems reliability index, estimated by using the fatigue elements with the fatigue strength expressed through SN relations, is found to be smaller than the systems reliability index estimated by using LEFM. It is shown that the systems reliability index is very sensitive to...

  18. Magnetic and gravity studies of Mono Lake, east-central, California

    Science.gov (United States)

    Athens, Noah D.; Ponce, David A.; Jayko, Angela S.; Miller, Matt; McEvoy, Bobby; Marcaida, Mae; Mangan, Margaret T.; Wilkinson, Stuart K.; McClain, James S.; Chuchel, Bruce A.; Denton, Kevin M.

    2014-01-01

    From August 26 to September 5, 2011, the U.S. Geological Survey (USGS) collected more than 600 line-kilometers of shipborne magnetic data on Mono Lake, 20 line-kilometers of ground magnetic data on Paoha Island, 50 gravity stations on Paoha and Negit Islands, and 28 rock samples on Paoha and Negit Islands, in east-central California. Magnetic and gravity investigations were undertaken in Mono Lake to study regional crustal structures and to aid in understanding the geologic framework, in particular regarding potential geothermal resources and volcanic hazards throughout Mono Basin. Furthermore, shipborne magnetic data illuminate local structures in the upper crust beneath Mono Lake where geologic exposure is absent. Magnetic and gravity methods, which sense contrasting physical properties of the subsurface, are ideal for studying Mono Lake. Exposed rock units surrounding Mono Lake consist mainly of Quaternary alluvium, lacustrine sediment, aeolian deposits, basalt, and Paleozoic granitic and metasedimentary rocks (Bailey, 1989). At Black Point, on the northwest shore of Mono Lake, there is a mafic cinder cone that was produced by a subaqueous eruption around 13.3 ka. Within Mono Lake there are several small dacite cinder cones and flows, forming Negit Island and part of Paoha Island, which also host deposits of Quaternary lacustrine sediments. The typical density and magnetic properties of young volcanic rocks contrast with those of the lacustrine sediment, enabling us to map their subsurface extent.

  19. Synthesis and Photocytotoxicity of Mono-functionalised Porphyrin with Valine Moiety

    Institute of Scientific and Technical Information of China (English)

    Wei Min SHI; Jian WU; Yi Feng WU; Kai Xian QIAN

    2004-01-01

    A mono-funtionalised tetraphenylporphyrin (TPP) bearing valine moiety at the phenyl ring was synthesized for photocytotoxicity examination in four steps, starting from regiospecific mono-nitration of TPP at the phenyl ring. The in vitro photocytotoxicitic effect against SPC-A1 adenocarcinona cell line was tested.

  20. Enantioselective recognition of mono-demethylated methoxychlor metabolites by the estrogen receptor.

    Science.gov (United States)

    Miyashita, Masahiro; Shimada, Takahiro; Nakagami, Shizuka; Kurihara, Norio; Miyagawa, Hisashi; Akamatsu, Miki

    2004-02-01

    Metabolites of methoxychlor such as 2-(p-hydroxyphenyl)-2-(p-methoxyphenyl)-1,1,1-trichloroethane (mono-OH-MXC) and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (bis-OH-MXC), have estrogenic activity. Mono-OH-MXC is a chiral compound in which the carbon atom bridging two benzene rings is the chiral centre. In previous studies the estrogenic activity of racemic mono-OH-MXC has been measured, and the activity of each enantiomer of this compound has not yet been elucidated. In this study, we evaluated the estrogen receptor-binding activity of each enantiomer of mono-OH-MXC to clarify the enantioselective recognition by the estrogen receptor. (S)-mono-OH-MXC showed 3-fold higher binding activity than that of the (R) enantiomer. The activity of bis-OH-MXC was only 1.7-fold higher than that of (S)-mono-OH-MXC. This result suggests that the one hydroxy group and the orientation of the CCl3 group of mono- and bis-OH-MXCs are important for the interaction with the estrogen receptor. The result also points out the estrogenic activity of methoxychlor after metabolic activation in vivo, which predominantly produces the (S)-mono-OH-MXC, may be higher than estimated from the in vitro activity of racemic mixtures.

  1. Digital mono- and 3D stereo-photogrammetry for geological and geomorphological mapping

    Science.gov (United States)

    Scapozza, Cristian; Schenker, Filippo Luca; Castelletti, Claudio; Bozzini, Claudio; Ambrosi, Christian

    2016-04-01

    corresponding real world pixel on the DEM, and then extract georeferenced vector data and orthorectified raster data from terrestrial photographs (Bozzini et al., 2012; Scapozza et al., 2014). Through some case studies, we show (1) how 3D digital stereo-photogrammetry makes it possible the production of Quaternary geological and geomorphological maps, (2) how digital mono-photogrammetry is a powerful tool for supporting geological mapping in very steep zones and (3) how the combination of these two digital tools permits diachronical mapping of phenomena evolution (such as landslides or rockglaciers) during the entire twentieth century. Ambrosi C. and Scapozza C. 2015. Improvements in 3-D digital mapping for geomorphological and Quaternary geological cartography. Geographica Helvetica 70: 121-133. doi: 10.5194/gh-70-121-2015 Bozzini C., Conedera M. and Krebs P. 2012. A new monoplotting tool to extract georeferenced vector data and orthorectified raster data from oblique non-metric photographs. International Journal of Heritage in the Digital Era 1: 499-518. doi: 10.1260/2047-4970.1.3.499 Scapozza C., Lambiel C., Bozzini C., Mari S. and Conedera M. 2014. Assessing the rock glacier kinematics on three different timescales: a case study from the southern Swiss Alps. Earth Surface Processes and Landforms 39: 2056-2069. doi: 10.1002/esp.3599

  2. Collide and Conquer: Constraints on Simplified Dark Matter Models using Mono-X Collider Searches

    CERN Document Server

    Brennan, A J; Gramling, J; Jacques, T D

    2016-01-01

    The use of simplified models as a tool for interpreting dark matter collider searches has become increasingly prevalent, and while early Run II results are beginning to appear, we look to see what further information can be extracted from the Run I dataset. We consider three `standard' simplified models that couple quarks to fermionic singlet dark matter: an $s$-channel vector mediator with vector or axial-vector couplings, and a $t$-channel scalar mediator. Upper limits on the couplings are calculated and compared across three alternate channels, namely mono-jet, mono-$Z$ (leptonic) and mono-$W/Z$ (hadronic). The strongest limits are observed in the mono-jet channel, however the computational simplicity and absence of significant $t$-channel model width effects in the mono-boson channels make these a straightforward and competitive alternative. We also include a comparison with relic density and direct detection constraints.

  3. Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients Efecto de dos dietas hipocalóricas en los niveles de transaminasas y resistencia a la insulina en pacientes obesos con hígado graso no alcohólico

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2010-10-01

    Full Text Available Objective: The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without NAFLD and the relation with insulin resistance. Research Methods: A population of 162 obese patients was randomly allocated to two groups: a diet I (low fat and b diet II (low carbohydrate, dieting along 3 months. Patients were classified as group I (n=112 when serum ALT activity was normal or group II (NAFLD, n=30 when serum ALT activity was ( > or = 43 UI/L. Results: In control group with diet I, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet I improved the same parameters and glucose, triglycerides, ALT, AST, gamaglutamine transferase levels, too. In control group with diet II, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet II improved the same parameters and glucose, triglycerides, ALT and gamaglutamine transferase levels, without statistical changes in AST. Conclusion: We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hipertransaminasemia and insulin resistance in NAFLD patients.Objetivo: El objetivo de nuestro trabajo fue evaluar los cambios en las transaminasas tras la perdida de peso en pacientes obesos con y sin esteatohepatitis no alcohólica (EHNA y su relación con la resistencia a la insulina. Material y métodos: Se aleatorizó una muestra de 162 pacientes obesos en dos grupos: a dieta I (baja en grasa y b dieta II (baja en hidratos de carbono, siguiendo al dieta durante 3 meses. Los pacientes se clasificaron como grupo I (n=112, con unos niveles de ALT normales y grupo II (EHNA, n=30 con unos niveles de ALT superiores a 43 UI/L. Resultados: En el grupo I con la dieta I disminuyó el

  4. Effects of physical exercise and nutritional guidance on metabolic syndrome in obese adolescents Efeito do exercício físico e da orientação nutricional na síndrome metabólica em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    N Leite

    2009-02-01

    Full Text Available OBJECTIVES: To analyze the effects of physical exercise and nutritional guidance on body composition, physical fitness, lipid profile and insulin resistance among obese adolescents with and without metabolic syndrome. METHODS: Sixty-four obese adolescents (26 boys, 10-16 years of age, were divided into two groups: with metabolic syndrome (n=29 and without metabolic syndrome (n=35. They were classified as having metabolic syndrome if they met three or more criteria for age and sex according to the Adult Treatment Panel III (ATP III. Blood pressure, waist circumference, maximum oxygen uptake (VO2peak, blood glucose, blood insulin, homeostatic model assessment (HOMA-IR, quantitative insulin sensitivity check index (QUICKI and lipid profile were assessed at baseline and after 12 weeks of intervention. Both groups participated in 12 weeks of physical education and two nutritional guidance sessions. Each physical education session consisted of 50 min indoor cycling, 50 min of walking/running and 20 min of stretching, three times a week. RESULTS: Fifty-five participants (with metabolic syndrome=25; without metabolic syndrome=30 completed the treatment. After 12 weeks, both groups showed reductions in body weight, BMI z-score, waist circumference, fat mass and triglycerides; and increases in height, HDL-C and VO2peak (pOBJETIVOS: Analisar os efeitos de exercícios físicos (EF e orientação nutricional (ON sobre a composição corporal, aptidão física, perfil lipídico e resistência insulínica em adolescentes obesos com e sem síndrome metabólica (SM. MÉTODOS: 64 obesos (26 meninos, com idade entre 10 a 16 anos, divididos em dois grupos: com SM (n=29 e sem SM (n=35. Utilizou-se como critério de classificação de SM a presença de três ou mais critérios para idade e sexo de acordo com Adult Treatment Panel III (ATP III. Mensuraram-se antes e após 12 semanas de intervenção: pressão arterial, circunferência abdominal, consumo máximo de

  5. Valoración diagnóstica y psicopatológica del trastorno por atracón en obesos mórbidos intervenidos de bypass gástrico Diagnostic and psychopathologic evaluation of binge eating disorder in gastric bypass patients

    Directory of Open Access Journals (Sweden)

    E. García Díaz

    2012-04-01

    Full Text Available Introducción: La presencia de trastorno por atracón (TA podría influir en los resultados del bypass gástrico laparoscópico (BPGL en el tratamiento de la obesidad mórbida. En población anglosajona, el TA suele valorarse mediante los cuestionarios Eating Disorder Examination-Questionnaire (EDE-Q y Questionnaire on Eating and Weight Patterns-Revised (QEWP-R. Objetivos: Estudiar la validez y concordancia del EDEQ y QEWP-R para el diagnóstico y valoración psicopatológica del TA en población española con obesidad mórbida intervenida mediante BPGL. Métodos: En un estudio transversal se le ha solicitado a 27 obesos mórbidos recién intervenidos mediante BPGL que cumplimentaran el EDE-Q y QEWP-R traducidos al español. Según las respuestas se han identificado los pacientes con y sin TA, evaluando posibles diferencias entre estos grupos en los ítems con interés psicométrico y midiendo la concordancia entre ambos cuestionarios. Resultados: El QEWP-R permitió diagnosticar un 25,9% de TA y el EDE-Q un 18,5%. Los pacientes con TA tuvieron mayores puntuaciones en los ítems sobre la importancia del peso o figura en la autovaloración, la interferencia en la capacidad de concentración por pensar en la comida, silueta o peso y la frecuencia del sentimiento de culpa después de comer. Entre ambos cuestionarios la concordancia diagnóstica fue escasa, pero se encontró una asociación fuerte entre los ítems con interés psicométrico. Conclusiones: El TA es frecuente en obesos mórbidos intervenidos mediante BPGL y forma un subgrupo de pacientes con más alteraciones psicopatológicas. El QEWP-R y el EDE-Q en español son cuestionarios adecuados para su valoración.Introduction: The presence of binge eating disorder (BED can influence the outcomes of laparoscopic gastric bypass (BPGL in the treatment of morbid obesity. In English population, BED is assessed usually through the Eating Disorder Examination-Questionnaire (EDE-Q and Questionnaire

  6. A New 62-sample Record of the Mono Lake Excursion Waveform from the Depocenter Sediments of Summer Lake, OR

    Science.gov (United States)

    Negrini, R. M.; McCuan, D. T.; Horton, R. A.; Verosub, K. L.

    2011-12-01

    A new core from Summer Lake, Oregon provides the primary datset for a composite, 62-sample record of the Mono Lake Excursion (MLE) waveform. The magnetograms and virtual geomagnetic poles (VGPs) are consistent with those associated with the MLE record from Mono Lake (e.g., Liddicoat and Coe, 1979). The added detail from this new record firmly establishes three distinct VGP clusters centered first on easternmost Asia/Siberia, then on Europe, and, finally, on North America. The jumps between clusters involve typically one sample, which represents only a few decades of time. The excursion is bracketed by tephra of known age (the Mount St. Helens Cy 46.0 ± 6 ka and the Wono 27.3 ± 0.3 14C kyr B.P.) and the age of the excursion is ~28 14C kyr B.P based on an average of five radiocarbon ages from below, within and above the excursion interval. A second waveform that exhibits shallowing inclinations and easterly declination swings upsection is truncated by a prominent unconformity. These PSV features and the associated RPI leading up to this unconformity correlate with those of the onset of the Laschamp Excursion (Lund et al., 2005). Both radiocarbon and PSV correlations support missing sediment from the Summer Lake record between 42.5 and 38 GISP2 ka. This sediment hiatus correlates to unconformities or lowstands in other Great Basin lakes suggesting a Heinrich 4-induced drought that affected much of western North America.

  7. Uso de dexmedetomidina em pacientes obesos mórbidos submetidos a gastroplastia: estabilidade cardiovascular e consumo de anestésicos venosos. Estudo retrospectivo Uso de dexmedetomidina en pacientes obesos mórbidos sometidos a gastroplastia: estabilidad cardiovascular y consumo de anestésicos venosos. Estudio retrospectivo Dexmedetomidine in morbid obese patients undergoing gastroplasty: cardiovascular stability and consumption of intravenous anesthetics. A retrospective study

    Directory of Open Access Journals (Sweden)

    Luiz Piccinini Filho

    2006-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A utilização de agentes anestésicos potentes e de curta duração é fundamental em pacientes submetidos à intervenção cirúrgica bariátrica. A dexmedetomidina, agonista alfa 2-adrenérgico, surgiu como uma opção adjuvante da técnica de anestesia venosa. O objetivo desta pesquisa foi avaliar a eficácia da dexmedetomidina associada à anestesia venosa, em pacientes obesos mórbidos, submetidos a gastroplastia. MÉTODO: Análise retrospectiva, de pacientes portadores de obesidade mórbida, submetidos à intervenção cirúrgica bariátrica aberta, sob anestesia com propofol e alfentanil acrescidos ou não de dexmedetomidina. Os pacientes foram alocados em dois grupos: Controle (propofol e alfentanil e Dexmedetomidina (propofol, alfentanil e dexmedetomidina. A manutenção da anestesia nos dois grupos constou de propofol = 0,075 a 0,1 mg.kg-1.min-1 e alfentanil = 0,75 a 1 µg.kg-1.min-1; no grupo Dexmedetomidina na dose inicial de 1 µg.kg-1 em 10 min e manutenção com 0,4 a 0,7 µg.kg-1.h-1. As variáveis estudadas foram idade, sexo, IMC, tempos cirúrgico e de despertar, freqüência cardíaca (FC, pressão arterial sistólica e diastólica (PAS, PAD, saturação periférica de hemoglobina (SpO2, consumo de propofol e alfentanil e efeitos colaterais. RESULTADOS: Houve redução significativa do consumo de propofol e alfentanil no grupo Dexmedetomidina. A FC apresentou variação significativa apenas no grupo Dexmedetomidina. A PAS e a PAD apresentaram redução estatística significativa nos dois grupos nos primeiros 20 min, estabilizando-se a seguir. Os pacientes dos dois grupos não apresentaram efeitos colaterais. CONCLUSÕES: Este estudo demonstrou a eficácia do uso da dexmedetomidina associada à anestesia venosa com propofol e alfentanil, promovendo redução do consumo dos anestésicos venosos, estabilidade cardiovascular e tempo de despertar similar à técnica sem adição de dexmedetomidina. N

  8. Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice

    DEFF Research Database (Denmark)

    Hansen, Jitka Stilund; Larsen, Søren Thor; Poulsen, Lars K.;

    2007-01-01

    Phthalates, including di(2-ethylhexyl) phthalate (DEHP), are widely used and have been linked with the development of wheezing and asthma. The main metabolite of DEHP, mono-2-ethylhexyl phthalate (MEHP), was investigated for adjuvant effects in a mouse inhalation model. BALB/cJ mice were exposed to...... aerosols of 0.03 or 0.4 mg/m(3) MEHP 5 days/week for 2 weeks and thereafter weekly for 12 weeks together with a low dose of ovalbumin (OVA) as a model allergen. Mice exposed to OVA alone or OVA+Al(OH)(3) served as negative and positive controls, respectively. Finally, all groups were exposed to a nebulized...... mediated by an IgG1-dependent mechanism. To address implications for humans, a margin-of-exposure was estimated based on the lack of significant effects on IgE production and inflammation after exposures to 0.03 mg/m(3) MEHP observed in the present study and estimated human exposure levels....

  9. Ferrous sulphate mono and heptahydrate reduction of hexavalent chromium in cement: effectiveness and storability

    Directory of Open Access Journals (Sweden)

    Valverde, J. L.

    2005-09-01

    Full Text Available In Community legislation, substances containing hexavalent chromium are classified as carcinogenic, mutagenic and sensitizing. In cement, hexavalent chromium intensifies sensitization and may set off severe allergic reactions in workers in routine contact with the product, whether in the factory or on construction sites. The allergic or contact dermatitis causes is a very painful disease that may lead to permanent worker disability. According to Directive 2003/53/EC of the European Parliament and the Council, Governments of all member countries will be required to prohibit the marketing and use, as of 17 January 2005, of any cement or cement preparation containing more than 2 ppm of chromium (VI. Hexavalent chromium can be reduced with ferrous sulphate to trivalent chromium, which is water-insoluble and therefore innocuous to the skin. The present paper reports the effects of adding ferrous sulphate mono- or heptahydrate to a commercial cement and the storage time of the mix on the concentration of hexavalent chromium. The salts studied were found to effectively reduce hexavalent chromium in cement for at least three months.

    Las sustancias que contienen cromo hexavalente están clasificadas en la legislación comunitaria como sustancias carcinogénicas, mutagénicas y sensibilizantes. El cromo hexavalente del cemento potencia la sensibilización y provoca graves reacciones alérgicas que sufren bastante a menudo los trabajadores que lo manipulan habitualmente, ya sea en fábrica o en el sector de la construcción. La dermatitis alérgica o de contacto que produce es muy dolorosa y puede dejar a los trabajadores en estado de discapacidad. La Directiva 2003/53/CE del Parlamento Europeo y del Consejo, exige a los Gobiernos de los países miembros, que a partir del 17 de enero de 2005, prohiban el uso y la comercialización de todos aquellos cementos y preparados que contengan cemento, cuyo contenido en cromo (VI soluble, una vez hidratados

  10. 21 CFR 582.4505 - Mono- and diglycerides of edible fats or oils, or edible fat-forming acids.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Mono- and diglycerides of edible fats or oils, or... GENERALLY RECOGNIZED AS SAFE Emulsifying Agents § 582.4505 Mono- and diglycerides of edible fats or oils, or edible fat-forming acids. (a) Product. Mono- and diglycerides of edible fats or oils, or edible...

  11. Separation of mono- and di-PEGylate of exenatide and resolution of positional isomers of mono-PEGylates by preparative ion exchange chromatography.

    Science.gov (United States)

    Nguyen, Ngoc-Thanh Thi; Lee, Jae Sun; Yun, Soi; Lee, E K

    2016-07-29

    Exenatide is a synthetic version of the 39-mer peptide of Exendin-4, which is an FDA-approved therapeutic against Type II diabetes mellitus. However, exenatide has a very short in-serum half-life and PEGylation have been performed to improve its in-serum stability. PEGylation often yields multivalent binding to non-specific residues, and the desired species should be carefully separated by chromatographies. In this study, we first devised an aqueous-phase, two-step PEGylation process. This consists of thiolation of Lys 12 and 27 residues followed by attachment of PEG-maleimide (10kD) to thiol groups. This process yields various species: mono-PEGylates with positional isomers, di-PEGylate, and other higher MW substances. A prep-grade cationic exchange chromatography (HiTrap SP) at pH 3.0 partially separated mono- and di-PEGylates based on the molar ratio of conjugated PEG and peptide and thus molecular weight of the conjugates. To further investigate the chromatographic separation of positional isomers of mono-PEGylates, we prepared two kinds of exenatide analogs by point mutation; K12C and K27C. Each analog was mono-PEGylated with very high yield (>95%). When a mixture of the two positional isomers of mono-PEGylates was applied to HiTrap SP chromatography, K12C-PEGylate and K27C-PEGylate eluted separately at 0.22M and 0.33M NaCl, respectively. When the proportions of acid and its conjugate base of the amino acid residues adjacent to the PEGylation site at pH 3.0 were analyzed, K27C-PEGylate shows stronger positive charge than K12C-PEGylate, and we propose the residence time difference between the two mono-PEGylates could be due to the charge difference. ELISA result shows that the immuno-binding activity of both analogs and their mono-PEGylates are well maintained. Furthermore, both mono-PEGylates of the analogs show higher than 50-fold improved anti-trypsin stability. We expect that mono-PEGylates of the exenatide analogs are alternatives to the conventional C40

  12. A 300 kyr Record of Geomagnetic Excursions and Paleointensity From the Irminger Basin: Candidates for Mono Lake, Laschamp, Iceland Basin, Jamaica and Pringle Falls?

    Science.gov (United States)

    Channell, J. E.

    2004-12-01

    Sediments recovered at ODP Site 919, off east Greenland, record geomagnetic directional excursions at 33 ka and 40 ka (Mono Lake and Laschamp), and at 187 ka (Iceland Basin), 208 ka (Jamaica?) and at 220 ka (Pringle Falls). U-channel records are augmented by 1-cm discrete samples collected back-to-back alongside the u-channel troughs. Deconvolution of the u-channel records yields records that can be closely matched to the discrete sample data. The age-model based on planktic oxygen isotope data (St. John et al., Marine Geology, in press) is consistent with the relative paleointensity record and the recognition of Ash Layer 2 (55 ka). The results indicate that the Mono Lake and Laschamp excursions, and the Iceland Basin and Pringle Falls (and perhaps also Jamaica), are distinct excursions, rarely recorded together in individual stratigraphic sections. Why are they recorded at ODP Site 919? Mean sedimentation rates are 22 cm/kyr in MIS 3 where Mono Lake/Laschamp are recorded, but sedimentation rates do not appear to be especially high in MIS 7 (13 cm/kyr) where candidates for Iceland Basin/Jamaica/Pringle Falls are recorded.

  13. Generation of high-energy mono-energetic heavy ion beams by radiation pressure acceleration of ultra-intense laser pulses

    International Nuclear Information System (INIS)

    Generation of high-energy mono-energetic heavy ion beams by radiation pressure acceleration (RPA) of intense laser pulses is investigated. Different from previously studied RPA of protons or light ions, the dynamic ionization of high-Z atoms can stabilize the heavy ion acceleration. A self-organized, stable RPA scheme specifically for heavy ion beams is proposed, where the laser peak intensity is required to match with the large ionization energy gap when the successive ionization state passes the noble gas configurations [such as removing an electron from the helium-like charge state (Z−2)+ to (Z−1)+]. Two-dimensional particle-in-cell simulations show that a mono-energetic Al13+ beam with peak energy 1.0 GeV and energy spread of only 5% can be obtained at intensity of 7×1020 W/cm2 through the proposed scheme. A heavier, mono-energetic, ion beam (Fe26+) can attain a peak energy of 17 GeV by increasing the intensity to 1022 W/cm2

  14. ALS - resources

    Science.gov (United States)

    Resources - ALS ... The following organizations are good resources for information on amyotrophic lateral sclerosis : Muscular Dystrophy Association -- mda.org/disease/amyotrophic-lateral-sclerosis National Amyotrophic Lateral Sclerosis (ALS) Registry -- ...

  15. Determination of mono ethanolamine by non-suppressed ion chromatography

    International Nuclear Information System (INIS)

    Mono ethanol amine (MEA) is world wide used as all volatile treatment agent to maintain alkaline pH in the entire steam water circuit of nuclear power station. Spectrophotometric method of MEA analysis suffers from interference in presence of hydrazine which is used as oxygen scavenger. A simple, rapid, accurate and quantitative determination of monoethanolamine (MEA) in coolant water was accomplished by cation exchange chromatography with conductometric detection in non-suppressed mode. A Metrosep cation 1-2 analytical column connecting with a Metrosep cartridge was used for cation separation. A solution containing a mixture of 4 mM tartaric acid, 1 mM dipicolinic acid, 20% acetone and 0.05 mM HNO3 was used as eluent. The limit of detection for MEA was 0.1 μg ml-1 and relative standard deviation was 2% for the overall method. The method was applied for the determination of MEA in steam generator water sample without any interference of hydrazine. The recovery was in the range of 95-102%. (author)

  16. The microbial arsenic cycle in Mono Lake, California.

    Science.gov (United States)

    Oremland, Ronald S; Stolz, John F; Hollibaugh, James T

    2004-04-01

    Significant concentrations of dissolved inorganic arsenic can be found in the waters of a number of lakes located in the western USA and in other water bodies around the world. These lakes are often situated in arid, volcanic terrain. The highest concentrations of arsenic occur in hypersaline, closed basin soda lakes and their remnant brines. Although arsenic is a well-known toxicant to eukaryotes and prokaryotes alike, some prokaryotes have evolved biochemical mechanisms to exploit arsenic oxyanions (i.e., arsenate and arsenite); they can use them either as an electron acceptor for anaerobic respiration (arsenate), or as an electron donor (arsenite) to support chemoautotrophic fixation of CO(2) into cell carbon. Unlike in freshwater or marine ecosystems, these processes may assume quantitative significance with respect to the carbon cycle in arsenic-rich soda lakes. For the past several years our research has focused on the occurrence and biogeochemical manifestations of these processes in Mono Lake, a particularly arsenic-rich environment. Herein we review some of our findings concerning the biogeochemical arsenic cycle in this lake, with the hope that it may broaden the understanding of the influence of microorganisms upon the speciation of arsenic in more common, less "extreme" environments, such as drinking water aquifers. PMID:19712427

  17. Mono- and di-cationic hydrido boron compounds.

    Science.gov (United States)

    Ghadwal, Rajendra S; Schürmann, Christian J; Andrada, Diego M; Frenking, Gernot

    2015-08-28

    Brønsted acid HNTf2 (Tf = SO2CF3) mediated dehydrogenative hydride abstraction from (L(1))BH3 () and (L(2))BH3 () (L(1) = IPrCH2 = 1,3-(2,6-di-isopropylphenyl)imidazol-2-methylidene (); L(2) = SIPrCH2 = 1,3-(2,6-di-isopropylphenyl)imidazolidin-2-methylidiene ()) affords thermally stable hydride bridged mono-cationic hydrido boron compounds [{(L(1))BH2}2(μ-H)](NTf2) () and [{(L(2))BH2}2(μ-H)](NTf2) (). Furthermore, hydride abstraction yields di-cationic hydrido boron compounds [{(L(1))BH}2(μ-H)2](NTf2)2 () and [{(L(2))BH}2(μ-H)2](NTf2)2 (). Unique cationic boron compounds with CH2BH2(μ-H)BH2CH2 ( and ) and CH2BH(μ-H)2BHCH2 ( and ) moieties feature a 3c-2e bond and have been fully characterized. Interesting electronic and structural features of compounds are analysed using spectroscopic, crystallographic, and computational methods. PMID:26200103

  18. On the mono-exponential fitting of phosphorescence decays

    Science.gov (United States)

    Fuhrmann, N.; Brübach, J.; Dreizler, A.

    2014-08-01

    Several methods for mono-exponential fitting of decay curves are presented and compared among each other in terms of precision, accuracy and computational time. Simulated noisy data sets are generated and evaluated in order to determine the main contributors to a loss in performance. The influence of the temporal discretization of the decay curve on the precision of the fitting methods is discussed. Correlations between the background offset and the decay time are analyzed. Variations of the signal-to-noise ratio are shown, allowing for evaluation of systematic errors and precision in the presence of noise. Finally, the algorithms are applied to experimental data, and the computational efforts for the different algorithms are compared. The results of this latter investigation confirm the conclusions drawn from the simulated data and the following conclusions are drawn: The frequently applied method of performing a linear regression to the logarithm of a background-corrected decay showed systematic errors in the presence of noise. Best results in terms of precision and accuracy were obtained by a nonlinear least-squares approximation and a method denoted as the linear regression of the sum. Additionally, this latter method required the lowest computational time and is finally recommended for determining decay times from experimental data.

  19. Mono-THF ring annonaceous acetogenins from Annona squamosa.

    Science.gov (United States)

    Hopp, D C; Alali, F Q; Gu, Z M; McLaughlin, J L

    1998-03-01

    Continuing work on the bark of Annona squamosa Rich. (Annonaceae), directed by the brine shrimp lethality test (BST), has resulted in the isolation of three new Annonaceous acetogenins, 4-deoxyannoreticuin, cis-4-deoxyannoreticuin, and (2,4-cis and trans)-squamoxinone. The first two are additional examples of acetogenins isolated from this plant species which contain the unusual feature of an oxygen functionality at the C-9 position. They have a hydroxylated mono-THF ring with respective threo/trans/threo and threo/cis/threo relative stereochemistries. The latter compound is a ketolactone mixture which has the same relative stereochemistry around the THF ring and the same spatial relationship between the THF ring and the hydroxyl group along the aliphatic chain as 4-deoxyannoreticuin, but is two methylene units longer. Additionally, the isolated hydroxyl group is at C-11, while the THF ring starts at C-17, instead of at C-9 and C-15, respectively, as for the first two compounds. All three compounds showed moderate, but significant, cytotoxicities against a panel of six human tumor cell lines with (2,4 cis and trans)-squamoxinone showing promising selectivity against the pancreatic cell line (PACA-2). PMID:9542173

  20. THE RECOGNITION OF SPOKEN MONO-MORPHEMIC COMPOUNDS IN CHINESE

    Directory of Open Access Journals (Sweden)

    Yu-da Lai

    2012-12-01

    Full Text Available This paper explores the auditory lexical access of mono-morphemic compounds in Chinese as a way of understanding the role of orthography in the recognition of spoken words. In traditional Chinese linguistics, a compound is a word written with two or more characters whether or not they are morphemic. A monomorphemic compound may either be a binding word, written with characters that only appear in this one word, or a non-binding word, written with characters that are chosen for their pronunciation but that also appear in other words. Our goal was to determine if this purely orthographic difference affects auditory lexical access by conducting a series of four experiments with materials matched by whole-word frequency, syllable frequency, cross-syllable predictability, cohort size, and acoustic duration, but differing in binding. An auditory lexical decision task (LDT found an orthographic effect: binding words were recognized more quickly than non-binding words. However, this effect disappeared in an auditory repetition and in a visual LDT with the same materials, implying that the orthographic effect during auditory lexical access was localized to the decision component and involved the influence of cross-character predictability without the activation of orthographic representations. This claim was further confirmed by overall faster recognition of spoken binding words in a cross-modal LDT with different types of visual interference. The theoretical and practical consequences of these findings are discussed.

  1. Adding Mono- and Multivalent Ions to Lyotropic Chromonic Liquid Crystals

    Science.gov (United States)

    Tortora, Luana; Park, Heung-Shik; Antion, Kelly; Woolwerton, Chris; Finotello, Daniele; Lavrentovich, Oleg

    2006-03-01

    Lyotropic Chromonic Liquid Crystals (LCLCs) are a distinct class of liquid crystals formed in aqueous solutions by molecules with rigid polyaromatic cores and ionic groups at the periphery [1-4]. The phase diagrams of these materials should depend on entropic factors (as in the Onsager model) and electrostatic interactions. Using optical polarizing microscopy, we studied the effects of mono- and multivalent ions on the phase diagrams of Blue 27 [3] and Sunset Yellow [2]. The monovalent ions change the temperatures of phase transitions, as described in [4], while the effect of multivalent ions is more dramatic and, in addition to the changed temperatures of phase transitions by tens of degrees, it often involves condensation of LCLC aggregates into domains with birefringence much higher than that in a normal nematic phase. Work supported by OBR B-7844. [1]J. Lydon, Current Opin. Colloid & Interface Sci. 3, 458 (1998);8, 480-489 (2004); [2]V. R. Horowitz, L. A. Janowitz, A. L. Modic, P. J. Heiney, and P. J. Collings, 2005, Phys. Rew. E 72, 041710; [3]Yu. A. Nastishin, H. Liu, T. Schneider, T., V. Nazarenko, R. Vasyuta, S. V. Shiyanovskii, and O. D. Lavrentovich, 2005, Phys. Rev. E 72, 041711; [4]A.F. Kostko, B. H. Cipriano, O. A. Pinchuk, L. Ziserman, M. A. Anisimov, D. Danino, and S. R. Raghavan. J. Phys. Chem. B 109, 19126-19133 (2005)

  2. Relación del estrés oxidativo y la pérdida de peso obtenida en pacientes obesos mórbidos mediante cirugía bariátrica con la técnica del cruce duodenal

    Directory of Open Access Journals (Sweden)

    Leonardo De Tursi Ríspoli

    2013-08-01

    Full Text Available Introducción: El estrés oxidativo, presente de forma evidente en los obesos mórbidos, es un indicador del estado inflamatorio crónico que representa la obesidad y posible nexo de unión con sus comorbilidades, algunas de las cuales son un importante factor de riesgo para el desarrollo de enfermedades cardiovasculares, por lo que la atenuación de su intensidad se ha convertido en un objetivo terapéutico. Material y método: Hemos intervenido de forma consecutiva, mediante la técnica quirúrgica del cruce duodenal, a 28 pacientes afectos de obesidad mórbida, realizando un estudio del estrés oxidativo presente en ellos mediante la determinación de productos de oxidación molecular y de antioxidantes, en el preoperatorio y a lo largo de un año tras la cirugía. Se ha controlado la evolución ponderal y la evolución de las comorbilidades presentes. Resultados: Los pacientes de la serie presentaron una media de edad de 43 ± 1 años y un IMC medio de 50,3. El 82% presentó comorbilidad asociada. Tras la cirugía todos los pacientes perdieron peso de forma progresiva a lo largo del periodo estudiado, con mejoría paralela de las comorbilidades y disminución progresiva de los valores del EO y mejoría de los sistemas antioxidantes, siendo los valores de EO al finalizar el estudio similares a los de la población normal. Conclusión: La pérdida de peso obtenida consigue una mejora de las comorbilidades y de los valores de estrés oxidativo de modo que al final del estudio los resultados obtenidos son similares a los de la población normal. Palabras clave: estrés oxidativo, obesidad, obesidad mórbida, cruce duodenal, pérdida de peso.

  3. Uso de preditores clínicos simples no diagnóstico pré-operatório de dificuldade de intubação endotraqueal em pacientes portadores de obesidade Uso de predictores clínicos sencillos en el diagnóstico preoperatorio de dificultad de intubación endotraqueal en pacientes obesos Use of simple clinical predictors on preoperative diagnosis of difficult endotracheal intubation in obese patients

    Directory of Open Access Journals (Sweden)

    Edno Magalhães

    2013-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar da semelhante incidência de dificuldade à laringoscopia em obesos e não obesos há mais relatos de dificuldade de intubação endotraqueal em portadores de obesidade. Alternativas de diagnóstico e previsão de dificuldade de intubação no pré-operatório podem ajudar diminuir complicações anestésicas em indivíduos obesos. O objetivo do estudo foi identificar preditores para diagnóstico de via aérea difícil em pacientes obesos, pela correlação com métodos clínicos de avaliação pré-anestésica e polissonografia. Comparou-se também a incidência de dificuldade à ventilação sob máscara facial e à laringoscopia entre obesos e não obesos, verificando os preditores mais prevalentes. MÉTODOS: Estudo observacional, prospectivo, comparativo, com 88 pacientes adultos, submetidos à anestesia geral. No período pré-operatório, avaliou-se questionário sobre preditores clínicos de síndrome da apneia obstrutiva do sono (SAOS e parâmetros anatômicos. Durante a anestesia, pesquisou-se dificuldade à ventilação sob máscara facial e laringoscopia. Para análise, estatística descritiva e teste de correlação. RESULTADOS: Os pacientes foram alocados em dois grupos, 43 obesos e 45 não obesos. Estado físico, prevalência de roncos, hipertensão e diabetes mellitus, circunferência cervical e índice de Mallampati foram maiores nos obesos. Pacientes obesos apresentaram maior incidência de dificuldade de ventilação sob máscara e laringoscopia. Nenhuma variável clínica ou anatômica apresentou correlação com dificuldade de ventilação sob máscara nos grupos. Nos obesos, o diagnóstico de SAOS mostrou forte correlação com dificuldade à laringoscopia. CONCLUSÕES: Os diagnósticos clínico e polissonográfico de SAOS se mostraram úteis no diagnóstico pré-operatório de dificuldade à laringoscopia. Pacientes obesos estão mais propensos à dificuldade de ventilação sob máscara e

  4. Avaliação ecocardiográfica em obesos graves assintomáticos Echocardiography evaluation for asymptomatic patients with severe obesity

    Directory of Open Access Journals (Sweden)

    Isaura Elaine Gonçalves Moreira Rocha

    2007-01-01

    Full Text Available OBJETIVO: Estudar a função sistólica e diastólica por meio da ecocardiografia Doppler em pacientes assintomáticos com obesidade grave. MÉTODOS: Foram avaliados, por meio de ecocardiograma transtorácico, 30 pacientes candidatos a cirurgia bariátrica, com IMC médio de 49,2±8,8 kg/m², sem história de cardiopatia prévia. RESULTADOS: Observou-se aumento de câmaras esquerdas em 42,9% da amostra, disfunção diastólica em 54,6%, hipertrofia ventricular esquerda em 82,1%, com padrão geométrico do tipo hipertrofia excêntrica em metade dos casos. A indexação da massa ventricular esquerda com a altura diagnosticou significativamente mais hipertrofia do que a indexação com a superfície corpórea (p = 0,0053, sendo esse índice mais apropriado para determinação de hipertrofia ventricular em obesos. Correlações entre hipertrofia ventricular esquerda com tempo de obesidade e níveis pressóricos foram positivas, bem como correlações entre o índice de massa corpórea e indicadores de disfunção diastólica. CONCLUSÃO: Este estudo mostrou que o ecocardiograma, realizado em portadores de obesidade grave assintomáticos, revelou alterações cardíacas estruturais comuns na miocardiopatia da obesidade, que podem associar-se ao desenvolvimento de insuficiência cardíaca, arritmias e morte súbita, possibilitando a identificação de pacientes sob maior risco cardiovascular.OBJECTIVE: To study the systolic and diastolic function of asymptomatic patients with severe obesity using a Doppler echocardiography. METHODS: Thirty candidates for bariatric surgery, with an average BMI of 49.2 ± 8.8 Kg/m² and no previous history of heart disease were evaluated through transthoracic echocardiography. RESULTS: Enlarged left chambers were observed in 42.9% of the sample, diastolic dysfunction in 54.6% and left ventricular hypertrophy in 82.1%, of which 50% of the cases presented the geometric pattern of eccentric hypertrophy. Indexation of left

  5. Aspectos nutricionais em obesos antes e após a cirurgia bariátrica Nutrition aspects in obese before and after bariatric surgery

    Directory of Open Access Journals (Sweden)

    Isabella Valois Pedrosa

    2009-08-01

    Full Text Available OBJETIVO: Determinar perfil clínico-nutricional de pacientes obesos submetidos à cirurgia bariátrica, no HC/UFPE. MÉTODOS: Foram avaliados retrospectivamente, 205 pacientes, no período 2002/2006. A análise considerou história clínica para diabetes tipo 2 (DM 2, hipertensão arterial (HA e síndrome metabólica (SM. O estado nutricional pré-operatório foi avaliado pelo IMC e bioquímica (hemoglobina, hematócrito, albumina, proteínas totais, triglicérides (TG, colesterol associado à lipoproteína de alta (HDLc e baixa (LDLc densidade e glicemia de jejum (GJ. Nos períodos pós-operatórios (6, 12, 18, 24 meses a avaliação nutricional foi feita pelas medidas de peso, perda ponderal, percentual de perda de peso (%PP, IMC e bioquímica incluindo ferro, ferritina e transferrina. RESULTADOS: 71,2% eram do sexo feminino, idade de 38,4 ± 9,96 anos, 129,66±27,40 Kg e IMC 48,6 ± 8,9 Kg/m², no pré-operatório. Receberam o diagnóstico de SM 26,8%, HA 52,7% e DM 2 11,7%. A bioquímica revelou TG, LDLc, GJ elevados, estando normais os demais parâmetros. Evolução antropométrica demonstrou perda ponderal progressiva, atingindo aos 24 meses IMC 31,7±5,82 Kg/m² (pOBJECTIVE: To determine the physical-nutritional profile of obese patients submitted to bariatric surgery at the HC/UFPE. MEHTODS: Two-hundred-and-five patients were evaluated retrospectively during the period of 2002 through 2006. Analysis considered clinical history for diabetes type 2 (DM 2, high blood pressure (HBP and metabolic syndrome (MS. The preoperative nutritional status was evaluated by MBI and the biochemistry (hemoglobin, hematocrit, albumin, total proteins, triglycerides (TG, cholesterol associated with the lipoprotein of high (HDLc and low (LDLc density and fasting glycemia (FG. During the postoperative periods (6, 12, 18, 24 months, we evaluated the nutritional status through measures of weight, weight loss, weight loss percentage (%WL, MBI and biochemistry

  6. White tea (Camellia sinensis extract reduces oxidative stress and triacylglycerols in obese mice Extrato de chá branco reduz extresse oxidativo e triacilglicerois em camundongos obesos

    Directory of Open Access Journals (Sweden)

    Lílian Gonçalves Teixeira

    2012-12-01

    com 0,5% de extrato de chá branco durante 8 semanas. Foram estudadoso tecido adiposo bem como o perfil lipídico e o estresse oxidativo. A suplementação com chá branco não foi capaz de reduzir a ingestão alimentar, peso corporal ou adiposidade visceral. De forma similar, não foram encontradas diferenças no perfil de lipoproteínas ricas em colesterol. Uma redução de triacilgliceróis sanguíneos, associada ao aumento de lipídios cecais, foi observada no grupo suplementado com chá branco. A suplementação também reduziu o estresse oxidativo no fígado e tecido adiposo. Em conclusão, suplementação com extrato de chá branco (0,5% não interfere no peso corporal ou adiposidade em camundongos obesos. Seus benefícios são restritos redução do estresse oxidativo associada obesidade e melhora da hipertrigliceridemia.

  7. Influencia de un programa de actividad física en niños y adolescentes obesos con apnea del sueño: protocolo de estudio

    Directory of Open Access Journals (Sweden)

    M. J. Aguilar Cordero

    2013-06-01

    Full Text Available Estudios recientes muestran un incremento alarmante en la tasa de sobrepeso/obesidad entre la población infanto-juvenil. La obesidad en la infancia se asocia con un importante número de complicaciones, como síndrome de apnea del sueño insulinorresistencia y diabetes tipo 2, hipertensión, enfermedad cardiovascular, algunos tipos de cáncer. Se estima que la prevalencia de apnea en niños es de un 2-3% en la población general, mientras que, en adolescentes obesos, varía entre el 13% y el 66%, según distintos estudios. Se asocia con la afectación de la función neurocognitiva, comportamiento, sistema cardiovascular, alteraciones metabólicas y del crecimiento. La apnea del sueño es un grave problema de salud pública que aumenta cuando los niños y adolescentes padecen sobrepeso y obesidad. Se postula el ejercicio de resistencia aeróbica como un tratamiento efectivo para la obesidad y la apnea de forma conjunta. El objetivo de este estudio es conocer si la actividad física en niños con sobrepeso/obesidad disminuye la apnea del sueño. Se realizará un estudio observacional, descriptivo, prospectivo, longitudinal con niños que padecen apnea del sueño y obesidad. El universo estará constituido por 60 niños y adolescentes con edades comprendidas entre 10 y 18 años que acudan a la consulta de endocrinología por tener obesidad en el Hospital Clínico San Cecilio de Granada durante el período de septiembre 2012-septiembre 2013. La muestra estará formada por niños y adolescentes que cumplan estas características y que sus padres/tutores hayan autorizado a través del consentimiento informado. La apnea del sueño se medirá en los niños mediante una polisomnografía y un cuestionario de calidad del sueño. También se hará una valoración nutricional a través de un cuestionario de frecuencia de consumo alimentario y una valoración antropométrica. De entre los resultados esperados están el bajar el sobrepeso y obesidad en los ni

  8. Estrategia probesci: un abordaje terapéutico de menor coste para el paciente obeso Probesci strategy: a cheaper therapeutic approach for obese patients

    Directory of Open Access Journals (Sweden)

    C. Vázquez

    2006-12-01

    Full Text Available Desde la experiencia clínica todas las evidencias hacen suponer que la obesidad, epidemia que amenaza la Salud Pública de los países más ricos de la Tierra, se presenta como un síndrome que abarca distintas enfermedades, todas ellas con un rasgo común, el exceso de grasa corporal, pero con respuestas clínicas claramente diferenciadas ante la misma estrategia terapéutica. Si las respuestas son tan heterogéneas es que la etiopatogenia también lo es, por lo que un estudio fenotípico exhaustivo ayudaría a establecer grupos clínicos que presumiblemente tendrían una respuesta más homogénea ante el mismo tratamiento. En este caso el abordaje y manejo terapéutico de los distintos grupos clínicos permitiría diversificar el tratamiento y posiblemente, mejorar su efectividad. El gran inconveniente para llevar a la práctica un estudio fenotípico exhaustivo es el elevado coste, por el consumo de tiempos recursos humanos que exige, lo que es con frecuencia inviable. En este estudio se describe la "estrategia PROBESCI" como un sistema organizativo de estudio y recogida de datos que sistematiza, estandariza y caracteriza la información constituyendo la base para la consiguiente clasificación y establecimiento de perfiles fenotípicos dentro de la obesidad. Es una nueva modalidad de consulta inicial en grupo, de valoración del paciente obeso, que ha demostrado su viabilidad. Se estudian los costes de esta nueva modalidad, comparándolos con los de la consulta clásica y se demuestra que supone un gran ahorro, ya que disminuye un 58% los costes de la consulta inicial y un 21% los costes totales del tratamiento.Obesity has become epidemic in Western countries. From clinical practice, obestity may be considered as a disease characterized by an excess of body fat mass, but patients usually demonstrate different responses to the same therapeutic strategy. It could be possible that the latter may be a consecuence of different pathophysiological

  9. Developing C# Apps for iPhone and iPad using MonoTouch

    CERN Document Server

    Costanich, Bryan

    2011-01-01

    Developing C# Applications for iPhone and iPad using MonoTouch shows you how to use your existing C# skills to write apps for the iPhone and iPad. Fortunately, there's MonoTouch, Novell's .NET library that allows C# developers to write C# code that executes in iOS. Furthermore, MonoTouch allows you to address all the unique functions of the iPhone, iPod Touch, and iPad. And the big plus: You needn't learn any Objective-C to master MonoTouch!. Former Microsoft engineer and published app-store developer Bryan Costanich shows you how to use the tools you already know to create native apps in iOS

  10. DECHLORINATION ACTIVITY (CROSS-ACCLIMATION) OF FRESHWATER SEDIMENTS ADAPTED TO MONO- AND DI-CHLOROPHENOLS

    Science.gov (United States)

    The reductive dechlorination of chlorophenols (CPs) in sediment slurries (10% solids) adapted to dechlorinate mono- and di-CPs (DCP) was investigated to define the regiospecificity of the dechlorination reaction. nadapted sediment slurries amended with various ortho-substituted C...

  11. 21 CFR 573.820 - Polyoxyethylene glycol (400) mono- and dioleates.

    Science.gov (United States)

    2010-04-01

    ... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.820 Polyoxyethylene glycol (400) mono- and dioleates... in calf-milk replacer formulations....

  12. Mono-Cycle Photonics and Optical Scanning Tunneling Microscopy Route to Femtosecond Ångstrom Technology

    CERN Document Server

    Yamashita, Mikio; Morita, Ryuji

    2005-01-01

    "Mono-Cycle Photonics and Optical Scanning Tunneling Microscopy" deals with both the ultrashort laser-pulse technology in the few- to mono-cycle region and the laser-surface-controlled scanning-tunneling microscopy (STM) extending into the spatiotemporal extreme technology. The former covers the theory of nonlinear pulse propagation beyond the slowly-varing-envelope approximation, the generation and active chirp compensation of ultrabroadband optical pulses, the amplitude and phase characterization of few- to mono-cycle pulses, and the feedback field control for the mono-cycle-like pulse generation. In addition, the wavelength-multiplex shaping of ultrabroadband pulse is described. The latter covers the CW-laser-excitation STM, the femtosecond-time-resolved STM and atomic-level surface phenomena controlled by femtosecond pulses.

  13. Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones

    Institute of Scientific and Technical Information of China (English)

    Xing Yong Wang; Jing Nan Cui; Wei Min Ren; Feng Li; Chun Liang Lu; Xu Hong Qian

    2007-01-01

    Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity, the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h.By control of the reaction time and in the presence of DMF as co-solvent, the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84% yields with 10-93% ee.

  14. Mono-chlorophenol degradation by pseudomonas putida CP1 and a mixed microbial population

    OpenAIRE

    Farrell, Alan

    2000-01-01

    A commercial mixed culture, Biolyte HAB, degraded mono-chlorophenols using a metci- cleavage pathway. 2- and 3-chlorophenol degradation was incomplete, leading to the accumulation of dead-end metabolites. Biolyte HAB was capable of the complete degradation of 2.34 mM 4-chlorophenol, via the intermediate 5-chloro-2- hydroxymuconic semialdehyde, using the meta- cleavage pathway. Pseudomonas putida CPI degraded mono-chlorophenols to completion via an orthocleavage pathway. The ability of P. ...

  15. Geothermal systems of the Mono Basin-Long Valley region, eastern California and western Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, C.T.; Flynn, T.; Chapman, R.H.; Trexler, D.T.; Chase, G.R.; Bacon, C.F.; Ghusn, G. Jr.

    1985-01-01

    The region that includes Mono Basin, Long Valley, the Bridgeport-Bodie Hills area, and Aurora, in eastern California and western Nevada was studied to determine the possible causes and interactions of the geothermal anomalies in the Mono Basin-Long Valley region as a whole. A special goal of the study was to locate possible shallow bodies of magma and to determine their influence on the hydrothermal systems in the region. (ACR)

  16. Stochastic resonance in a mono-stable system with multiplicative and additive noise

    International Nuclear Information System (INIS)

    The stochastic resonance in a biased mono-stable system subject to multiplicative and additive noise is investigated. Based on the adiabatic approximation theory, the analytic expression of the signal-to-noise ratio (SNR) is obtained. It is shown that the SNR is a non-monotonic function of the intensities of the multiplicative and additive noise, as well as the parameters of the mono-stable system

  17. Implementasi Secure Hash Algorithm (SHA) Dan Substitusi Mono Alfabet Dalam Sistem Pengamanan Data

    OpenAIRE

    Raja Salomo Tarigan

    2009-01-01

    Penggunaan data digital dalam dunia sekarang ini sudah meliputi hampir semua aspek. Salah satu upaya pengamanan data digital yang dapat dilakukan adalah kriptografi. Teknik kriptografi klasik seperti Substitusi Mono Alphabet tidak pernah digunakan lagi karena tidak dapat menyaingi kompleksitas teknik kriptografi yang lain oleh karena kesederhanaannya. Oleh karena itu timbul suatu gagasan untuk menggunakan kembali algoritma kriptografi klasik seperti Substitusi Mono Alphabet dengan cara mengga...

  18. Tratamento multidisciplinar reduz o tecido adiposo visceral, leptina, grelina e a prevalência de esteatose hepática não alcoólica (NAFLD em adolescentes obesos Tratamiento multidisciplinar reduce el tejido adiposo visceral, leptina, grelina y la prevalencia de esteatosis hepática no alcohólica (NAFLD en adolescentes obesos Multidisciplinary treatment reduces visceral adiposity tissue, leptin, ghrelin and the prevalence of non-alcoholic fat liver disease (NAFLD in obese adolescents

    Directory of Open Access Journals (Sweden)

    Ana R. Dâmaso

    2006-10-01

    Full Text Available O objetivo do presente estudo foi avaliar as alterações promovidas, por intervenção multidisciplinar, nas concentrações plasmáticas de grelina e leptina, adiposidade visceral e prevalência de esteatose hepática não alcoólica (NAFLD, em adolescentes obesos. Foram avaliados 28 adolescentes obesos, 16 meninas (IMC 34,58 ± 3,86kg/m² e 12 meninos (IMC 37,08 ± 3,17kg/m², com idade entre 15 e 19 anos, quanto à concentração de leptina, grelina, insulina, assim como a adiposidade visceral e o diagnóstico de NAFLD pelo método de ultra-sonografia. Os resultados demonstraram redução significante na concentração circulante de grelina e leptina e na adiposidade visceral (p El objetivo del presente trabajo ha sido evaluar las alteraciones promovidas por la intervención multidisciplinar, en las concentra- ciones plasmáticas de grelina y leptina, adiposidad visceral y prevalencia de esteatosis hepática no alcohólica - NAFLD, en adolescentes obesos. 28 adolescentes obesos, 16 chicas (IMC 34,58 ± 3,86 kg/m² y 12 chicos (IMC 37,08 ± 3,17 kg/m², con edades entre 15 y 19 años, fueron evaluados respecto a la concentración de leptina, grelina, insulina, así como a la adiposidad visceral y el diagnóstico de NAFLD por el método de ultrasonografía. Los resultados demostraron una reducción significante en la concentra- ción circulante de grelina y leptina y en la adiposidad visceral (p The aim of this study was to assess the changes promoted by a multidisciplinary therapy in ghrelin and leptin concentrations, visceral adiposity and non-alcoholic fat liver disease-NAFLD, in obese adolescents. A total of 28 obese adolescents, 16 girls (BMI 34.58 ± 3,86 wt/ht² and 12 boys (BMI 37.08 ± 3.17 wt/ht², aged between 15 and 19 years old, was evaluated to leptin, ghrelin and insulin concentrations, visceral adiposity and NAFLD through ultrasonography. The results showed a significant decrease in ghrelin, leptin concentrations and visceral

  19. OVERVIEW OF MONO-ENERGETIC GAMMA-RAY SOURCES & APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Hartemann, F V; Albert, F; Anderson, G G; Anderson, S G; Bayramian, A J; Betts, S M; Chu, T S; Cross, R R; Ebbers, C A; Fisher, S E; Gibson, D J; Ladran, A S; Marsh, R A; Messerly, M J; O' Neill, K L; Semenov, V A; Shverdin, M Y; Siders, C W; McNabb, D P; Barty, C P; Vlieks, A E; Jongewaard, E N; Tantawi, S G; Raubenheimer, T O

    2010-05-18

    Recent progress in accelerator physics and laser technology have enabled the development of a new class of tunable gamma-ray light sources based on Compton scattering between a high-brightness, relativistic electron beam and a high intensity laser pulse produced via chirped-pulse amplification (CPA). A precision, tunable Mono-Energetic Gamma-ray (MEGa-ray) source driven by a compact, high-gradient X-band linac is currently under development and construction at LLNL. High-brightness, relativistic electron bunches produced by an X-band linac designed in collaboration with SLAC NAL will interact with a Joule-class, 10 ps, diode-pumped CPA laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. This MEGa-ray source will be used to excite nuclear resonance fluorescence in various isotopes. Applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. The source design, key parameters, and current status are presented, along with important applications, including nuclear resonance fluorescence. In conclusion, we have optimized the design of a high brightness Compton scattering gamma-ray source, specifically designed for NRF applications. Two different parameters sets have been considered: one where the number of photons scattered in a single shot reaches approximately 7.5 x 10{sup 8}, with a focal spot size around 8 {micro}m; in the second set, the spectral brightness is optimized by using a 20 {micro}m spot size, with 0.2% relative bandwidth.

  20. Climate Change Impacts to Water Quality in the Owens and Mono Lake Basins

    Science.gov (United States)

    Chen, L.; Roy, S. B.; Mills, B.; Kurkjian, R.

    2011-12-01

    This study describes work to identify potential impacts of future climate changes on water quality in the Mono and Owens Lake basins that are sources of water supply to City of Los Angeles through the Los Angeles Aqueduct (LAA) System. A watershed hydrology and water quality model (the Hydrological Simulation Program Fortran-HSPF; Bicknell et al. 1996) was adapted to the basin to evaluate the potential impacts of climate change on water quality. The water quality parameters studied in this work include temperature, dissolved oxygen (DO), biochemical oxygen demand (BOD), total suspended solids (TSS), nutrients (nitrogen as nitrate and phosphorus as ortho-phosphate), chlorophyll a, total organic carbon (TOC), and arsenic. The model was calibrated to baseline water quality data observed for the period of 1994-2004 at six major locations, including streams and reservoirs. Statistically downscaled temperature and precipitation data from six climate models were used to make future projections of water quality impacts: GFDL CM2.1, CNRM CM3, NCAR PCM1.1, CCSM3, ECHAMS/MPI-OM, and MIROC3.2, and projections developed for 2005-2099. Results from this modeling exercise indicate that by the end of the 21st century, the following changes may occur in the watershed: increases in water temperature by 1-2 oC; decreases in DO, average TSS, and arsenic; increases in nutrients, both nitrogen and phosphorus species; and minimal changes in BOD and TOC. The recommended actions of the modeling analysis include more detailed monitoring for selected parameters to provide a foundation for evaluating long term trends and relationships of flow and concentrations of key constituents such as TSS, nutrients, and arsenic that are of interest from the standpoint of drinking water supply.

  1. Catalytic Activity of Mono- and Bi-Metallic Nanoparticles Synthesized via Microemulsions

    Directory of Open Access Journals (Sweden)

    Ramona Y.G. König

    2014-07-01

    Full Text Available Water-in-oil (w/o microemulsions were used as a template for the synthesis of mono- and bi-metallic nanoparticles. For that purpose, w/o-microemulsions containing H2PtCl6, H2PtCl6 + Pb(NO32 and H2PtCl6 + Bi(NO3, respectively, were mixed with a w/o-microemulsion containing the reducing agent, NaBH4. The results revealed that it is possible to synthesize Pt, PtPb and PtBi nanoparticles of ~3–8 nm in diameter at temperatures of about 30°C. The catalytic properties of the bimetallic PtBi and PtPb nanoparticles were studied and compared with monometallic platinum nanoparticles. Firstly, the electrochemical oxidation of formic acid to carbon monoxide was investigated, and it was found that the resistance of the PtBi and PtPb nanoparticles against the catalyst-poisoning carbon monoxide was significantly higher compared to the Pt nanoparticles. Secondly, investigating the reduction of 4-nitrophenol to 4-aminophenol,we found that the bimetallic NPs are most active at 23 °C, while the order of the activity changes at higher temperatures, i.e., that the Pt nanoparticles are the most active ones at 36 and 49 °C. Furthermore, we observed a strong influence of the support, which was either a polymer or Al2O3. Thirdly, for the hydrogenation of allylbenzene to propylbenzene, the monometallic Pt NPs turned out to be the most active catalysts, followed by the PtPb and PtBi NPs. Comparing the two bimetallic nanoparticles, one sees that the PtPb NPs are significantly more active than the respective PtBi NPs.

  2. Comportamientos sesgados según el sexo en el mono aullador negro y dorado (Alouatta caraya

    Directory of Open Access Journals (Sweden)

    Kowalewski, Martín M.

    2005-01-01

    Full Text Available Entender el comportamiento de los primates no-humanos permite entre otras cosas conocer el comportamiento de nuestros ancestros. El liderazgo en los desplazamientos puede influir en diferentes aspectos de la vida en grupo tales como el forrajeo y la defensa del territorio. Los trabajos que estudian estos aspectos en primates, se concentran en la relación entre el sexo del individuo que lidera un desplazamiento y su asociación con diferentes contextos comportamentales. Publicaciones en diversas especies indican que las hembras lideran desplazamientos hacia los sitios de alimentación, lo que estaría relacionado a una prioridad alimenticia. Los machos, en cambio, tienden a liderar desplazamientos hacia encuentros con otros grupos en defensa del territorio y de las hembras. En este trabajo presentamos información preliminar sobre el liderazgo de los desplazamientos de dos grupos de A. caraya, en la Isla Brasilera (20º 20`S, 58º 40`O, Chaco, Argentina. Las tropas fueron estudiadas 5 días por mes desde de Mayo a Noviembre de 2004 desde el amanecer hasta el anochecer. Se registraron 319 desplazamientos, donde al menos el 50% del grupo completaba el viaje entre diferentes sitos. Cuando los contextos fueron considerados juntos, no hubo diferencias significativas en el sexo que lideraba (X2=0.2, df=1, p>0.05. Se observó que los desplazamientos dirigidos a sitios de alimentación fueron liderados por hembras y los dirigidos hacia peleas, por machos (G=17.2, df=2, p<0.05. La división según el sexo en los desplazamientos de los monos aulladores y otras especies de primates nos permite inferir que la selección ha actuado sobre los comportamientos sesgados por sexo en el Orden Primates.

  3. Efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I Effects of greater-than-5% weight reduction on hemodynamic, metabolic and neuroendocrine profiles of grade I obese subjects

    OpenAIRE

    Kelly Biancardini Gomes Barbato; Rita de Cássia Vieira Martins; Maria de Lourdes Guimarães Rodrigues; José Ueleres Braga; Emílio Antonio Francischetti; Virginia Genelhu

    2006-01-01

    OBJETIVO: Avaliar os efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I. MÉTODOS: Estudo observacional com 47 obesos grau I, média de idade de 33 anos, submetidos a orientação mensal quanto a dieta, exercício físico e comportamento alimentar, durante quatro meses. A pressão arterial, pelo método auscultatório, e a freqüência cardíaca, pelo método palpatório, foram avaliadas mensalmente, enquanto as seguintes variáveis (e respectivos ...

  4. El mono gramático y el sabio alquimista. Algunas reflexiones en torno a la poética de Octavio Paz en El Mono Gramático

    Directory of Open Access Journals (Sweden)

    Óscar Pujol

    2014-04-01

    Full Text Available El presente artículo es una comparación entre la poética de Octavio Paz en El Mono Gramático y un autor indio del siglo XI Abhinavagupta, a quien llamamos el Sabio Alquimista en referencia a la teoría india de la emoción estética: el rasa. Una idea subyacente en ambos autores es que el lenguaje ordinario enmascara la realidad, mientras que el lenguaje poético se resuelve en una abolición de la escritura que nos enfrenta a una realidad indecible. Se comparan un total de seis características distintas y se llega a la conclusión que la mayor discrepancia entre ambos autores es la naturaleza de esa realidad innombrable que revela la poesía. Para el autor indio se trata de una realidad inefable y gozosa: la conciencia pura. Para Paz es una realidad insoportable y enloquecedora, aunque al mismo tiempo fascinante. La diferencia es cultural, pues la tradición india adora a esa realidad innombrable mientras que la modernidad occidental desconfía de un absoluto inmensurable e impositivo. En este sentido Paz ejemplifica el dilema del hombre moderno: angustia ante esa realidad anterior al lenguaje, pero también una fascinación que busca en el arte y la poesía su modo último de expresión.

  5. Diazoalkane addition reaction on the fullerene dimer C120O and characterization of the resulting mono-adduct.

    Directory of Open Access Journals (Sweden)

    Uwe Ritter

    2008-06-01

    Full Text Available A mono-adduct of the fullerene dimer C120O was prepared via a diazoalkane addition reaction to obtain rod-like analogue of[60]PCBM opening the possibility to make photovoltaic and photosensitive layers of supra-molecular and anisotropic order.The mono-adduct was obtained as a mixture containing five isomers. The structure of the mono-adduct was verified bymass-, IR-, and 1H-NMR-spectroscopies. The mono-adduct is readily soluble in common fullerene solvents and shows abroader and stronger optical absorption than [60]PCBM. The mono-adduct features a similar acceptor strength as [60]PCBMand [70]PCBM, is stable in air below 150 °C and in nitrogen below 500 °C. The mono-adduct is expected to be a valuablematerial for photovoltaic and photosensitive applications.

  6. Vitamina C restaura pressão arterial e a resposta vasodilatadora no antebraço em crianças obesas Vitamina C restaura presión arterial y respuesta vasodilatadora en el antebrazo en niños obesos Vitamin C restores blood pressure and vasodilator response during mental stress in obese children

    Directory of Open Access Journals (Sweden)

    Pricilla Regina Oliveira Fernandes Fernandes

    2011-06-01

    ónico de la suplementación de vitamina C (VitC sobre la presión arterial y en la respuesta vasodilatadora al estrés mental. MÉTODOS: En este estudio prospectivo, randomizado y doble ciego fueron evaluados niños obesos, de ambos géneros, con edades entre 8 y 12 años divididos en 2 grupos: 1 grupo de niños suplementados con 500 mg de vitamina C (n = 11 y, 2 substancia placebo (n = 10 durante 45 días. Ocho niños eutróficos, pareados por edad también fueron incluidos en el estudio. Fueron evaluados la presión arterial media (PAM, la frecuencia cardíaca (ECG y el flujo sanguíneo en el antebrazo por plestimografía de oclusión venosa. La conductancia vascular en el antebrazo (CVA fue obtenida por medio de la relación entre el flujo sanguíneo en el antebrazo y la PAM (X100. RESULTADOS: Antes de la intervención, los niños obesos presentaron PAM mayor y CVA menor cuando fueron comparados con el Grupo C. Post intervención, el Grupo VitC presentó reducción de la PAM en reposo (81 ± 2 vs 75 ± 1 mmHg, p = 0,01, mientras en el Grupo Placebo no hubo alteración de la PAM (p = 0,58. Adicionalmente, VitC promovió un aumento de la CVA en reposo (3,40 ± 0,5 vs 5,09 ± 0,6 un, p = 0,04 y durante el estrés mental (3,92 ± 0,5 vs 6,68 ± 0,9 un, p = 0,03. Además de eso, post suplementación con VitC, los niveles de la CVA fueron estadísticamente semejantes a los del Grupo C en reposo (5,09 ± 0,6 vs 5,82 ± 0,4 un, p > 0,05 y durante el estrés mental (6,68 ± 0,9 vs 7,35 ± 0,5 un, p > 0,05. CONCLUSIÓN: Suplementación con VitC redujo la presión arterial y restableció la respuesta vasodilatadora periférica en niños obesos.BACKGROUND: Peripheral vasodilation response plays an important role in the pathophysiology of obesity and heart disease. OBJECTIVE: To evaluate the chronic effect of vitamin C (VitC supplementation on blood pressure and on vasodilation response to mental stress. METHODS: In a double-blind, randomized and prospective study we evaluated obese

  7. Quality of life of obese patients submitted to bariatric surgery Calidad de vida en pacientes obesos sometidos a cirugía bariátrica

    Directory of Open Access Journals (Sweden)

    N. Barreto Villela

    2004-11-01

    pacientes con obesidad mórbida (OM se ve reducida dadas las restricciones que esta situación impone. Se considera que la cirugía bariátrica es un tratamiento eficaz para la OM puesto que conduce a una reducción notable y progresiva del peso. Perder peso, el consejo dietético adecuado y el seguimiento pueden favorecer una mejoría notable en la QOL. Objetivo: Evaluar el grado de QOL en pacientes con OM, antes y después de la cirugía bariátrica (gastroplastia reductora de Fobi-Capella. Casos, material y métodos: Noventa y cinco pacientes obesos mórbidos (IMC > 40 kg/m², o moderados (IMC 35 -39 kg/m² con comorbilidades, fueron vistos, seguidos y recibieron consejo por parte del personal de Nutrición, Psicología, Endocrinología y Cirugía del Federal University Bahia Hospital. El grupo I incluía individuos en la etapa prequirúrgica y el grupo II se componía de 29 pacientes distintos en una etapa posquirúrgica avanzada. A los pacientes del grupo II se les vio a los 6, 12 y más meses después de la cirugía bariátrica. Se utilizó el estudio de resultados médicos Short Form Health Survey (SF-36 para evaluar la QOL en este estudio. Se analizaron los datos utilizando el método no paramétrico de Mann-Whitney y el programa SPSS. Resultados: Se detectó una mejoría estadísticamente significativa en la QOL, en los aspectos de salud general, capacidad funcional y vitalidad. Se vio una mejoría progresiva en la forma física, particularmente en los pacientes que habían sido sometidos a cirugía bariátrica en los últimos 12 meses, entre los 6 y 12 meses, y hacía más de 6 meses. Se vieron pequeños cambios en los puntos subjetivos. Se observó un cambio en los aspectos sociales tras una caída posquirúrgica. Esto explica el porqué los cambios no se ven cuando se comparan pacientes pre y posquirúrgicos. Conclusiones: La cirugía bariátrica de Fobi-Capella en nuestros pacientes con obesidad mórbida o con obesidad moderada y comorbilidades asociadas supuso

  8. Crianças e adolescentes obesos: dois anos de acompanhamento interdisciplinar Obese children and adolescents: two years of interdisciplinary follow-up

    Directory of Open Access Journals (Sweden)

    Mariana Porto Zambon

    2008-06-01

    Full Text Available OBJETIVO: Avaliar dois anos de seguimento de crianças e adolescentes obesos em ambulatório especializado. MÉTODOS: Trata-se de coorte, com coleta retrospectiva dos dados de 150 pacientes (1 a 19 anos de idade do Ambulatório de Obesidade do Hospital de Clínicas da Universidade Estadual de Campinas. Destes pacientes, 53% eram do sexo masculino e 63% eram de Campinas, São Paulo. A média da idade no início de ganho de peso foi 4,3 anos. Dos 150 pacientes, 128 retornaram uma vez, com avaliação de peso, altura, índice de massa corpórea (IMC e escores Z. Foram realizados hemograma, glicemia de jejum, insulina basal, relação glicemia/insulina, triglicérides, colesterol total e frações. Os pacientes foram divididos em dois grupos, de acordo com o seguimento. Entre os grupos, foi analisada a diferença entre idade, sexo, procedência, idade de início, acantose nigricans e os escores Z de peso, altura e IMC, proporção de exames laboratoriais alterados e a diferença dos escores Z de IMC em relação à primeira consulta. RESULTADOS: Dos 128 pacientes, 57% permaneceram em seguimento, sendo que 114 retornaram pelo menos uma vez. Comparando os grupos, os moradores de Campinas foram os que mais abandonaram o ambulatório, sem diferenças em relação às demais variáveis clínicas, antropométricas e laboratoriais estudadas. Houve queda da média do escore Z do IMC em ambos os grupos, em relação à consulta inicial. CONCLUSÕES: Os pacientes deste estudo apresentaram redução da média do escore Z do IMC semelhante à literatura. Apesar do alto índice de abandono, não foram identificados fatores de risco que o justificassem, com exceção da procedência da criança.OBJECTIVE: To study two years follow-up of obese children and adolescents from a specialized out-patient clinic. METHODS: This cohort study with retrospective collection of data enrolled 150 patients (1 to 19 years old, 53% males, 63% from Campinas, São Paulo, Brazil, and

  9. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    OpenAIRE

    Dongjuan Yuan; Dongming Lan; Ruipu Xin; Bo Yang; Yonghua Wang

    2014-01-01

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity ...

  10. Variação do diâmetro da artéria braquial em crianças obesas: presente e futuro Variación del diámetro de la arteria braquial en niños obesos: presente y futuro Variation of the brachial artery diameter in obese children: present and future

    Directory of Open Access Journals (Sweden)

    Karla Cristina M. Costa

    2012-09-01

    Full Text Available OBJETIVO: Revisão da literatura acerca do uso da medida da variação do diâmetro da artéria braquial por ultrassonografia de alta resolução (dilatação mediada por fluxo como preditor de risco para doença cardiovascular em crianças e adolescentes obesos. FONTES DE DADOS: Levantamento de publicações indexadas no Medline/PubMed de trabalhos publicados entre 2002 e 2011, rastreadas com a combinação dos descritores: "endothelium", "child", "ultrasonography" e "obesity", além de estudos e textos clássicos sobre o tema. Foram encontradas 54 publicações e 32 delas foram incluídas na presente revisão do tema. SINTESE DOS DADOS: O estudo da disfunção endotelial tem sido empregado como preditor de risco para doenças cardiovasculares, tais como aterosclerose e doença cardíaca coronariana, visto que a lesão endotelial é um importante evento na fisiopatologia de tais doenças. CONCLUSÕES: A dilatação mediada por fluxo da artéria braquial mostra-se importante como ferramenta diagnóstica e prognóstica na avaliação da função endotelial de crianças e adolescentes com excesso de peso por ser um método não invasivo, com boa aplicabilidade quanto ao custo, à inocuidade e ao benefício.OBJETIVO: Revisión de la literatura sobre el uso de la medida de la variación del diámetro de la arteria braquial, por ultrasonografía de alta resolución (dilatación mediada por flujo, como predictor de riesgo para enfermedad cardiovascular en niños y adolescentes obesos. FUENTES DE DATOS: Inventario de publicaciones indizadas en Medline/Pubmed de trabajos publicados entre 2002 y 2011, buscadas mediante la combinación de los descriptores: «endothelium», «child», «ultrasonography» y «obesity», además de estudios y textos clásicos sobre el tema. Se encontraron 54 publicaciones y 32 de ésas fueron incluidas en la presente revisión del tema. Síntesis de los datos: El estudio de la disfunción endotelial viene siendo empleado

  11. Ultrasonication of pyrogenic microorganisms improves the detection of pyrogens in the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    The monocytic cell line Mono Mac 6 is sensitive to pyrogens. When exposed to pyrogens secretion of interleukin-6 is induced. However, some eukaryotic pyrogenic microorganisms are not detectable. The aim of this study is to introduce a pretreatment of samples to expand the detection range of the a......The monocytic cell line Mono Mac 6 is sensitive to pyrogens. When exposed to pyrogens secretion of interleukin-6 is induced. However, some eukaryotic pyrogenic microorganisms are not detectable. The aim of this study is to introduce a pretreatment of samples to expand the detection range...... of the assay. The interleukin-6 inducing capacity of a broad spectrum of UV-killed and ultrasonicated microorganisms is examined in Mono Mac 6 cells. The interleukin-6 secretion is determined in a sandwich immunoassay (DELFIA). The Mono Mac 6 assay is able to detect UV-killed Bacillus subtilis, Staphylococcus......, ultrasonication of S. aureus results in a 100-fold increase in the interleukin-6 response. Even after ultrasonication Streptococcus faecalis can not be detected. Ultrasonication is an easy and simple method for expanding the detection range in the Mono Mac 6 assay....

  12. High resolution seismic reflection profiles of Holocene volcanic and tectonic features, Mono Lake, California

    Science.gov (United States)

    Jayko, A. S.; Hart, P. E.; Bursik, M. I.; McClain, J. S.; Moore, J. C.; Boyle, M.; Childs, J. R.; Novick, M.; Hill, D. P.; Mangan, M.; Roeske, S.

    2009-12-01

    The Inyo-Mono Craters of Long Valley and Mono Basin, California are the youngest eruptive vents of the Great Basin, USA and the second youngest in California. They are one of two seismically active volcanic centers with geothermal power production in the Walker Lane, western Great Basin, the other being the Coso Volcanic Field to the south. High resolution seismic reflection data collected from the northern tip of the Mono Craters eruptive centers in Mono Lake delinates two structural zones proximal to the active volcanic centers in Mono Lake. A growth structure drapped by ~30 m or more of bedded sediment shows increasing deformation and offset of clastic deposits on the northwest margin of the basin. Coherent thin-bedded stratigraphic sections with strong reflectors to 30-100m depth are preserved on the western and northern margins of the basin. The southern and southeastern areas of the lake are generally seismically opaque, due to extensive ash and tephra deposits as well as widespread methane. Thin pockets of well-bedded, poorly consolidated sediment of probable Holocene and last glacial age are present within intrabasin depressions providing some local age constraints on surfaces adjacent to volcanic vents and volcanically modified features.

  13. MAGNESIUM MONO POTASSIUM PHOSPHATE GROUT FOR P-REACTOR VESSEL IN-SITU DECOMISSIONING

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Stefanko, D.

    2011-01-05

    The objective of this report is to document laboratory testing of magnesium mono potassium phosphate grouts for P-Reactor vessel in-situ decommissioning. Magnesium mono potassium phosphate cement-based grout was identified as candidate material for filling (physically stabilizing) the 105-P Reactor vessel (RV) because it is less alkaline than portland cement-based grout (pH of about 12.4). A less alkaline material ({<=} 10.5) was desired to address a potential materials compatibility issue caused by corrosion of aluminum metal in highly alkaline environments such as that encountered in portland cement grouts. Information concerning access points into the P-Reactor vessel and amount of aluminum metal in the vessel is provided elsewhere. Fresh and cured properties were measured for: (1) commercially blended magnesium mono potassium phosphate packaged grouts, (2) commercially available binders blended with inert fillers at SRNL, (3) grouts prepared from technical grade MgO and KH{sub 2}PO{sub 4} and inert fillers (quartz sands, Class F fly ash), and (4) Ceramicrete{reg_sign} magnesium mono potassium phosphate-based grouts prepared at Argonne National Laboratory. Boric acid was evaluated as a set retarder in the magnesium mono potassium phosphate mixes.

  14. Magnesium Mono Potassium Phosphate Grout For P-Reactor Vessel In-Situ Decomissioning

    International Nuclear Information System (INIS)

    The objective of this report is to document laboratory testing of magnesium mono potassium phosphate grouts for P-Reactor vessel in-situ decommissioning. Magnesium mono potassium phosphate cement-based grout was identified as candidate material for filling (physically stabilizing) the 105-P Reactor vessel (RV) because it is less alkaline than portland cement-based grout (pH of about 12.4). A less alkaline material (≤ 10.5) was desired to address a potential materials compatibility issue caused by corrosion of aluminum metal in highly alkaline environments such as that encountered in portland cement grouts. Information concerning access points into the P-Reactor vessel and amount of aluminum metal in the vessel is provided elsewhere. Fresh and cured properties were measured for: (1) commercially blended magnesium mono potassium phosphate packaged grouts, (2) commercially available binders blended with inert fillers at SRNL, (3) grouts prepared from technical grade MgO and KH2PO4 and inert fillers (quartz sands, Class F fly ash), and (4) Ceramicrete(regsign) magnesium mono potassium phosphate-based grouts prepared at Argonne National Laboratory. Boric acid was evaluated as a set retarder in the magnesium mono potassium phosphate mixes.

  15. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Riou, Laurent; Ghezzi, Catherine [Universite Joseph Fourier, Grenoble (France); INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Poillot, Cathy; Cestele, Sandrine [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Desruet, Marie-Dominique [INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Couvet, Morgane; Bourgoin, Sandrine; Seve, Michel [CRI-INSERM U823, Grenoble (France). Inst. of Albert Bonniot; Universite Joseph Fourier, Grenoble (France); Waard, Michel de [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Smartox Biotechnologies, Grenoble (France)

    2014-07-01

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen {sup registered} or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H{sub 2}O{sub 2} was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  16. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    International Nuclear Information System (INIS)

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen registered or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H2O2 was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  17. Efeitos de misturas de napropamide e simazine no controle de mono e dicotiledoneas em cafeeiros novos Effects of napropamide and simazine mixtures on the control of mono and dicotyledon on new coffee trees

    Directory of Open Access Journals (Sweden)

    L.S.P. Cruz

    1980-12-01

    : napropamide at 2.00 and 3.00 kg/ha; simazine at 0.50 and 0.75 kg/ha; and tank mixtures of 2.00 kg/ha of napropamide with 0.50 and 0.75 kg/ha of simazine; and 3.00 kg/ha of napropamide also with 0.50 and 0.75 kg/ha of simazine. A treatment without herbicide was also included in the experiment. A weed count was done 45 days after the aplication of the herbicides, and every 15 days until the 90th day, visual observations were done to detect the percentage of weed infestations. At that time it was also done on the fitotoxicity symptoms caused by herbicides on the coffee trees. The most frequent weeds present in the trial were, Digitaria horizontalis Willd. Eleusine indica (L . Gaertn, Amaranthus viridis L. and Bidens pilosa L. As it was expected, the mixtures were much more effective than those alone. The mixtures were rather effective in the control of mono and dycotyledons which were present in the experiment. Al treatments with 0.75 kg/ha of simazine presented light symptoms of fitotoxicity, limited to some leaves of the coffee trees, till last observation.

  18. Mono- and Dimeric Phosphine Complexes of Cyclopentadienylvanadium(II) Halides

    NARCIS (Netherlands)

    Nieman, J.; Teuben, J.H.

    1986-01-01

    Reduction of CpVX2(PR3)2 (X = Cl, R = Me, Et; X = Br, R = Et) with Al or Zn in THF gives dimeric vanadium(II) complexes [CpVX(PR3)]2. Methylcyclopentadienyl compounds are accessible by the same method. Treating the dimers with an excess of PR3 gives CpVx(PR3)2, and treating the dimers with bidentate

  19. Resolving the age of Wilson Creek Formation tephras and the Mono Lake excursion using high-resolution SIMS dating of allanite and zircon rims

    Science.gov (United States)

    Vazquez, J. A.; Lidzbarski, M. I.

    2012-12-01

    Sediments of the Wilson Creek Formation surrounding Mono Lake preserve a high-resolution archive of glacial and pluvial responses along the eastern Sierra Nevada due to late Pleistocene climate change. An absolute chronology for the Wilson Creek stratigraphy is critical for correlating the paleoclimate record to other archives in the western U.S. and the North Atlantic region. However, multiple attempts to date the Wilson Creek stratigraphy using carbonates and interbedded rhyolitic tephras yield discordant 14C and 40Ar/39Ar results due to open-system effects, carbon reservoir uncertainties, as well as abundant xenocrysts entrained during eruption. Ion microprobe (SIMS) 238U-230Th dating of the final increments of crystallization recorded by allanite and zircon autocrysts from juvenile pyroclasts yields ages that effectively date eruption of key tephra beds and resolve age uncertainties about the Wilson Creek stratigraphy. To date the final several micrometers of crystal growth, individual allanite and zircon crystals were embedded in soft indium to allow sampling of unpolished rims. Isochron ages derived from rims on coexisting allanite and zircon (± glass) from hand-selected pumiceous pyroclasts delimit the timing of Wilson Creek sedimentation between Ashes 7 and 19 (numbering of Lajoie, 1968) to the interval between ca. 27 to ca. 62 ka. The interiors of individual allanite and zircon crystals sectioned in standard SIMS mounts yield model 238U-230Th ages that are mostly Mono Craters volcanism and/or intrusions. Tephra (Ash 15) erupted during the geomagnetic excursion originally designated the Mono Lake excursion yields a rim isochron age of ca. 41 ka indicating that the recorded event is instead the Laschamp excursion. The results are consistent with a depositional chronology from correlation of relative paleointensity (Zimmerman et al., 2006) that indicates quasi-synchronous glacial and hydrologic responses in the Sierra Nevada and Mono Basin to climate change

  20. Circulating adipocytokines in morbid obese patients, relation with cardiovascular risk factors and anthropometric parameters Adipocitoquinas circulantes en obesos mórbidos, relación con factores de riesgo cardiovascular y parámetros antropométricos

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2011-02-01

    Full Text Available Background: Obesity and insulin resistance are associated with cardiovascular risk factors, including adipocytokines. The aim of the present study was to explore the relation of circulating adipocytokines with cardiovascular risk and anthropometric parameters in morbid obese patients. Subjects: A population of 65 morbid obese patients was analyzed in a prospective way. A biochemical, anthropometric and dietary evaluation was realized. Results: In the multivariate analysis with resistin as dependent variable, the BMI remained in the model (F = 16.6; p Antecedentes: La obesidad y resistencia a la insulina se asocia con factores de riesgo cardiovascular, incluyendo adipocitoquinas. El objetivo del presente estudio fue explorar la relación de circulante adipocitoquinas con los p factores de riesgo cardiovascular y los parámetros antropométricos en pacientes obesos mórbidos. Pacientes: Una muestra de 65 pacientes obesos mórbidos se analizo de manera prospectiva. Se realizó a todos una bioquímica, estudio antropométrico y una evaluación dietética. Resultados: En el análisis multivariado con resistina como variable dependiente, el IMC se mantuvo en el modelo (F = 16,6, p < 0,05, con un aumento de 0,23 (IC 95%: 0,06-0,41 ng/ml con cada punto de índice de masa corporal. En un segundo modelo con la adiponectina como variable dependiente, la edad se mantuvo en el modelo (F = 4,46, p < 0,05, con un aumento de 3,62 (IC 95%: 0,05-7,21 ng/ml, con cada año. En el tercer modelo con la interleucina 6 como variable dependiente, el HOMA, la PCR y el peso se mantuvieron en el modelo (F = 8,8; p < 0,01, con un aumento de 0,26 (IC 95%: 0,05-0,47 pg/ml, con cada punto de HOMA, un aumento de 0,43 (IC 95%: 0,10-0,76 pg / ml con cada 1 mg/dl de PCR y un aumento de 0,13 (IC 95%: 0,05-0,21 pg/ml con cada kg de peso. En el cuarto modelo con TNF-alfa como variable dependiente; resistina, IL-6 y el peso se mantuvieron en el modelo (F = 5,2, p < 0,01, con un

  1. Modificações da qualidade de vida sexual de obesos submetidos à cirurgia de Fobi-Capella Changes the sexual quality of life of the obeses submitted Fobi-Capella gastroplasty surgery

    Directory of Open Access Journals (Sweden)

    Arakén Almeida de Araújo

    2009-02-01

    Full Text Available OBJETIVO: Analisar as modificações na qualidade de vida sexual de obesos, proporcionadas pela redução do peso corpóreo, após a realização da gastroplastia à Fobi-Capella. MÉTODOS: Estudo quantitativo, prospectivo e longitudinal com cortes transversais, realizado entre março de 2005 e março de 2007, com 21 obesos mórbidos. Critérios de inclusão: idade de 20 a 50 anos, índice de massa corpórea (IMC =40 Kg/m² e insucesso em tentativas de tratamento clínico para obesidade nos últimos dois anos. Coleta de dados clínicos em prontuários e aplicação de questionário específico com questões relativas à função sexual, realizadas antes e seis meses após a cirurgia. Os escores obtidos foram analisados com o auxilio do programa Epi-Info6, empregando o teste T de student para amostras pareadas. RESULTADOS: O valor total aumentou seis meses após a cirurgia em 76,19%, permaneceu inalterado em 14,29% e diminuiu em 9,52%. Os domínios referentes a função erétil e a relação sexual aumentaram em 71,42%, ao desejo sexual em 52,38% e ao orgasmo em 28,57%. A satisfação sexual aumentou em 57,14%. As médias do valor total e dos seus domínios antes e seis meses após a cirurgia, exceto aquelas referentes ao orgasmo e ao desejo sexual, apresentam diferenças estatisticamente significativas. CONCLUSÃO: A qualidade de vida sexual em homens obesos melhora após a realização da gastroplastia à Fobi-Capella. Evidenciaram-se modificações favoráveis na função sexual desses indivíduos após a perda de peso.OBJECTIVES: Examine changes in the quality of sexual life of men with morbid obesity offered by a reduction in body weight following Fobi-Capella gastroplasty. METHOD: A quantitative, prospective, longitudinal, cross-sectional study was carried out on 21 men with morbid obesity between March 2005 and March 2007. Inclusion criteria were: aged 20 to 50 years, body mass index (BMI = 40 kg/m² and failure in attempts of clinical

  2. Geochemical fingerprinting of Wilson Creek formation tephra layers (Mono Basin, California) using titanomagnetite compositions

    Science.gov (United States)

    Marcaida, Mae; Mangan, Margaret T.; Vazquez, Jorge A.; Bursik, Marcus; Lidzbarski, Marsha I.

    2014-03-01

    Nineteen tephra layers within the Wilson Creek formation near Mono Lake provide a record of late Pleistocene to early Holocene volcanic activity from the nearby Mono Craters and are important chronostratigraphic markers for paleomagnetic, paleoclimatic, and paleoecologic studies. These stratigraphically important tephra deposits can be geochemically identified using compositions of their titanomagnetite phenocrysts. Titanomagnetite compositions display a broad range (XUsp 0.26-0.39), which allow the tephra layers to be distinguished despite the indistinguishable major-element glass compositions (76-77 wt% SiO2) of their hosts. The concentrations of Ti and Fe in titanomagnetite display geochemical and stratigraphic groupings that allow clear discrimination between older (> 57 ka) and younger (Mono Craters-sourced titanomagnetites also allows the discrimination of two tephra layers apparently sourced from nearby Mammoth Mountain volcano in Long Valley.

  3. Anaerobic Halo-Alkaliphilic Baterial Community of Athalassic, Hypersaline Mono Lake in California

    Science.gov (United States)

    Pikuta, Elena V.; Hoover, Richard B.; Marsic, Damien; Ng, Joseph D.; Six, N. Frank (Technical Monitor)

    2002-01-01

    The microorganisms of soda Mono Lake and other similar athalassic hypersaline alkaline soda lakes are of significance to Astrobiology. The microorganisms of these regimes represent the best known terrestrial analogs for microbial life that might have inhabited the hypersaline alkaline lakes and evaporites confined within closed volcanic basins and impact craters during the late Noachian and early Hesperian epochs (3.6 - 4.2 Gya) of ancient Mars. We have investigated the anaerobic microbiota of soda Mono Lake in northern California. In this paper we discuss the astrobiological significance of these ecosystems and describe several interesting features of two novel new species of anaerobic halo-alkaliphilic bacteria (Spirochaeta americana, sp. nov. and Desulfonatronum paiuteum, sp. nov) that we have isolated from Mono Lake.

  4. Temperature dependent Raman spectroscopic study of mono-, bi-, and tri-layer molybdenum ditelluride

    Science.gov (United States)

    Park, June; Kim, Younghee; Jhon, Young In; Jhon, Young Min

    2015-10-01

    We investigate the thermal properties of mono-, bi- and tri-layer MoTe2 by using temperature-dependent Raman spectroscopy ranging from 90 K to 300 K. The E2g 1 and B2g 1 modes of MoTe2 blueshift as the temperature decreases. The temperature dependence of the peak positions obtained from mono- to tri-layer MoTe2 is analyzed using the Grüneisen model. The first order temperature coefficients of E2g 1 and B2g 1 Raman modes of mono- to tri-layer MoTe2 are extracted. This study provides the fundamental information about the thermal properties of MoTe2 layers, which is crucial for developing thermal and electronic applications of MoTe2 based devices.

  5. Evaluation of efficacy, reliability, and tolerability of sibutramine in obese patients, with an echocardiographic study Avaliação da eficácia, segurança e tolerabilidade da sibutramina em obesos - estudo randomizado duplo-cego

    Directory of Open Access Journals (Sweden)

    Alfredo Halpern

    2002-06-01

    Full Text Available This is a double-blind, placebo-controlled study of the efficacy, safety, and tolerability of sibutramine in the management of obese patients for a 6-month period. METHOD: Sixty-one obese patients (BMI >30, 10%, we observed a weight loss of >5% in 40% of the patients on sibutramine compared with 12.9% in the placebo group. We also detected weight gain in 45.2% of the placebo group compared to 20% in the sibutramine group. The sibutramine group showed improvement in HDL- cholesterol values (increased by 17% and triglyceride values (decreased by 12.8%. This group also showed an increase in systolic blood pressure (6.7%, 5 mmHg. There were no changes in echocardiograms comparing the beginning and end of follow-up, and side effects did not lead to discontinuation of treatment. DISCUSSION: Sibutramine proved to be effective for weight loss providing an 8% loss of the initial weight. Compliance to prolonged treatment was good, and side effects did not result in discontinuation of treatment. These data confirmed the good efficacy, tolerability, and safety profiles of sibutramine for treatment of obesity.O presente estudo objetivou comparar a eficácia, segurança e tolerabilidade da sibutramina em pacientes obesos. MÉTODO: Selecionamos 61 pacientes obesos (3010% ocorreu perda de peso>5% em 40% dos pacientes em uso da sibutramina vs 12,9% no grupo placebo e ganho de peso em 45,2% dos pacientes em uso de placebo vs 20% no grupo sibutramina. No grupo sibutramina notamos melhora dos níveis de HDL-colesterol (aumento de 17% e triglicerídeos (diminuição de 12,8%, neste grupo ocorreu também um aumento da pressão arterial sistólica (6,7%-5mmHg. Não houve alteração entre os ecocardiogramas do início e final do acompanhamento e os efeitos adversos não levaram à descontinuação do tratamento. DISCUSSÃO: A sibutramina mostrou-se eficaz na redução de peso, proporcionando um perda de 8% em relação ao peso inicial. Houve boa adesão do paciente ao

  6. Imagem corporal, ansiedade e depressão em pacientes obesos submetidos à cirurgia bariátrica Body image, anxiety and depression in obese patients submitted to bariatric surgery

    Directory of Open Access Journals (Sweden)

    Sebastião Sousa Almeida

    2012-04-01

    Full Text Available Pacientes obesos mórbidos têm recorrido à cirurgia bariátrica como um recurso eficaz para perder peso. Entretanto, este procedimento pode causar alterações comportamentais significativas. O objetivo deste trabalho foi investigar os níveis de ansiedade e depressão, assim como as mudanças sofridas na percepção da imagem corporal em pacientes obesos submetidos à cirurgia bariátrica em três momentos: pré-operatório, 6 meses e 12 meses após a cirurgia. Trata-se de um estudo do tipo prospectivo longitudinal, de abordagem quantitativa. No estudo foram aplicados os Inventários de Depressão e Ansiedade de Beck e a Escala Brasileira de Figuras de Silhuetas para Adultos. A cirurgia diminuiu significativamente tanto o índice de massa corporal dos pacientes quanto a insatisfação com a sua imagem corporal. Essa perda de peso e diminuição da insatisfação com a imagem corporal foi acompanhada de redução nos níveis de ansiedade e depressão, o que sugere que estes são fatores importantes no quadro obesidade.Morbidly obese patients often have resorted to bariatric surgery as an effective resource to be used for weight loss. However, this procedure can cause significant behavioral changes. The objective of this study was to investigate levels of anxiety and depression, as well as the changes suffered in the perception of body image in obese patients undergoing bariatric surgery at three different times: preoperatively, 6 months and 12 months after surgery. This is a prospective longitudinal study of a quantitative approach. The study used the Beck Depression Inventory, the Beck Anxiety Inventory and the Brazilian Scale of Figures Silhouettes for Adults. Surgery significantly decreased both the body mass index of patients and dissatisfaction with their body image. This weight loss and decreased body image dissatisfaction was accompanied by reduced levels of anxiety and depression, suggesting that these are important factors in the

  7. Função diastólica do ventrículo esquerdo em obesos graves em pré-operatório para cirurgia bariátrica

    Directory of Open Access Journals (Sweden)

    Irlaneide da Silva Tavares

    2012-04-01

    Full Text Available FUNDAMENTO: Obesidade é uma doença crônica, multifatorial, associada a aumento do risco cardiovascular, especialmente a insuficiência cardíaca diastólica. OBJETIVO: Avaliar a função diastólica do ventrículo esquerdo em obesos graves em pré-operatório para cirurgia bariátrica, relacionando com os fatores de risco cardiovascular e a estrutura cardíaca. MÉTODOS: Trata-se de um estudo transversal, com 132 pacientes candidatos a cirurgia bariátrica, submetidos a avaliação ecocardiográfica transtorácica e dos fatores de risco cardiovascular, sendo: 97 mulheres (73,5%, idade média de 38,5 ± 10,5 anos e IMC de 43,7 ± 7,2 Kg/m². Foram divididos em três grupos: 61 com função diastólica normal, 24 com disfunção diastólica leve e 47 com disfunção diastólica moderada/grave, dos quais 41 com disfunção diastólica moderada (padrão pseudonormal e seis com disfunção diastólica grave (padrão restritivo. RESULTADOS: Hipertensão arterial sistêmica, idade e gênero foram diferentes nos grupos com disfunção diastólica. Os grupos com disfunção tiveram maior diâmetro do átrio esquerdo, do ventrículo esquerdo, volume do átrio esquerdo em quatro e duas câmaras, índice de volume atrial esquerdo e índice de massa do ventrículo esquerdo corrigido para a superfície corpórea e para altura. CONCLUSÃO: A elevada frequência de disfunção diastólica do ventrículo esquerdo na fase pré-clínica em obesos graves justifica a necessidade de uma avaliação ecocardiográfica criteriosa, com o objetivo de identificar indivíduos de maior risco, para que medidas de intervenção precoce sejam adotadas.

  8. Esteatose hepática não alcoólica: relação com a síndrome metabólica e os fatores de risco cardiovascular em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Wener Barbosa Resende

    2014-03-01

    Full Text Available Objetivo: Avaliar a associação entre esteatose hepática não alcoólica (EHNA, síndrome metabólica (SM e fatores de risco cardiovascular (FRCs em adolescentes obesos. Métodos: Estudo observacional do tipo transversal com abordagem quantitativa, realizado de junho a agosto de 2011. Os voluntários foram aleatoriamente selecionados e encaminhados para avaliação clínica no setor de endocrinologia e cardiologia do hospital de clínicas da Universidade Federal de Uberlândia. Participaram 34 adolescentes de 14 a 19 anos, acima do percentil 95 da curva de crescimento. A EHNA foi analisada por ultrassonografia. A SM e os FRCs foram identificados pelos critérios da International Diabetes Federation. Resultados: A amostra foi composta de 14 indivíduos do sexo masculino e 20 do sexo feminino, com idade (16,8±1,6 e índice de massa corporal (IMC (35,7±3,9. A ocorrência de EHNA e SM foi de 76,5% (n=26 e 50% (n=17, respectivamente. O sexo masculino apresentou maior ocorrência de EHNA (78,6%, n=11, SM (64,3%, n=09 e associação de EHNA com SM (50%, n=07. Em relação aos FRCs 100% (n=34, 61,8% (n=21 e 52,9% (n=18 dos adolescentes apresentaram valores aumentados da circunferência da cintura (CC, da lowdensity- lipoprotein cholesterol (LDL-C e pressão arterial sistólica (PAS, respectivamente, e 52,9% (n=18 apresentaram baixos valores de high-density lipoprotein cholesterol (HDL-C. Houve correlações entre SM e triglicerídeos, PAS e diastólica e HDL-C, e entre EHNA, IMC e CC. Conclusão: Observou-se uma alta ocorrência de EHNA, SM e FRCs em adolescentes obesos. Uma forte correlação foi observada entre EHNA e SM, e entre FRCs com EHNA e SM.

  9. Mono- and Dimeric Phosphine Complexes of Cyclopentadienylvanadium(II) Halides

    OpenAIRE

    Nieman, J.; Teuben, J.H.

    1986-01-01

    Reduction of CpVX2(PR3)2 (X = Cl, R = Me, Et; X = Br, R = Et) with Al or Zn in THF gives dimeric vanadium(II) complexes [CpVX(PR3)]2. Methylcyclopentadienyl compounds are accessible by the same method. Treating the dimers with an excess of PR3 gives CpVx(PR3)2, and treating the dimers with bidentate phosphines, CpVCl(DMPE) and CpVCl(DPPE) are obtained. All compounds are paramagnetic with, in principle, three unpaired electrons on the metal atom. 1H NMR spectra of the complexes show large down...

  10. Endospores of B subtilis are pyrogenic and activate Mono Mac 6 cells

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, Erik W; Christensen, Jens D;

    2003-01-01

    The monocytic cell line Mono Mac 6 is sensitive to pyrogens and interleukin-6 secretion is induced after exposure to pyrogens. The aim of this study is to examine the pyrogenic activity and the interleukin-6-inducing capacity of the Gram-positive B. subtilis bacteria, endospores and isolated cell...... wall components. Furthermore the involvement of CD14 in activation of interleukin-6 release is investigated. All test substances are pyrogenic in the rabbit pyrogen test. The test substance is incubated with monocytic cells (Mono Mac 6) for 24 h and the secreted interleukin-6 is determined...

  11. A study of the growth of Pseudomonas putida CP1 on mono-chlorophenols

    OpenAIRE

    Fakhruddin, A. N. M.

    2003-01-01

    Pseudomonas putida CPI grew on all three mono-chlorophenol isomers when supplied as the sole source of carbon and energy. The biodegradability of the mono-chlorophenols followed the order: 4-chlorophenol > 2-chlorophenol > 3-chlorophenol. P. putida CPI was able to degrade 300 ppm 4-chlorophenol, 250 ppm 2-chlorophenol and 200 ppm of 3-chlorophenol. In the presence of fructose (1%, w/v) the organism could degrade 400 ppm 4-chlorophenol, 500 ppm 2-chlorophenol and 300 ppm 3-chlorophenol. Ch...

  12. Systemic Cytokine and Interferon Responsiveness Patterns in HIV and HCV Mono and Co-Infections

    OpenAIRE

    Fernandez-Botran, Rafael; Joshi-Barve, Swati; Ghare, Smita; Barve, Shirish; Young, Mary; Plankey, Michael; Bordon, Jose

    2014-01-01

    The role of host response-related factors in the fast progression of liver disease in individuals co-infected with HIV and HCV viruses remains poorly understood. This study compared patterns of cytokines, caspase-1 activation, endotoxin exposure in plasma as well as interferon signaling in peripheral blood mononuclear cells from HIV/HCV co-infected (HIV+/HCV+), HCV mono-infected (HIV−/HCV+), HIV mono-infected (HIV+/HCV−) female patients and HIV- and HCV-uninfected women (HIV−/HCV−) who had en...

  13. A study on synthesis and oxidation mechanism of mono-alkyl phosphate

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Oxidation of white phosphorus by peroxides to produce mono-alkyl phosphate in the alcoholic solution has been studied under non-and catalytic conditions. In this paper,the mechanism of the oxidation process was analyzed. The content of mono-alkyl phosphate in the product is affected by different types of alcoholic solution and peroxide solvent. The result shows the availability of the following order for the activity of the peroxide solvent and alcoholic solutions-tert-butyl hydroperoxide>(di) benzoyl perox...

  14. Self-assembled and electrochemically deposited mono/multilayers for molecular electronics applications

    International Nuclear Information System (INIS)

    For the development of molecular electronics, it is desirable to investigate characteristics of organic molecules with electronic device functionalities. In near future, such molecular devices could be integrated with silicon to prepare hybrid nanoelectronic devices. In this paper, we review work done in our laboratory on study of characteristics of some functional molecules. For these studies molecular mono and multilayers have been deposited on silicon surface by self-assembly and electrochemical deposition techniques. Both commercially available and specially designed and synthesized molecules have been utilized for these investigations. We demonstrate dielectric layers, memory, switching, rectifier and negative differential resistance devices based on molecular mono and multilayers.

  15. HMM and IOHMM for the Recognition of Mono- and Bi-Manual 3D Hand Gestures

    OpenAIRE

    Just, Agnès; Bernier, O.; Marcel, Sébastien

    2004-01-01

    In this paper, we address the problem of the recognition of isolated complex mono- and bi-manual hand gestures. In the proposed system, hand gestures are represented by the 3D trajectories of blobs obtained by tracking colored body parts. In this paper, we study the results obtained on a complex database of mono- and bi-manual gestures. These results are obtained by using Input/Output Hidden Markov Model (IOHMM), implemented within the framework of an open source machine learning library, and...

  16. Recognition of Isolated Complex Mono- and Bi-Manual 3D Hand Gestures

    OpenAIRE

    Just, Agnès; Bernier, O.; Marcel, Sébastien

    2004-01-01

    In this paper, we address the problem of the recognition of isolated complex mono- and bi-manual hand gestures. In the proposed system, hand gestures are represented by the 3D trajectories of blobs. Blobs are obtained by tracking colored body parts in real-time using the EM algorithm. In most of the studies on hand gestures, only small vocabularies have been used. In this paper, we study the results obtained on a more complex database of mono- and bi-manual gestures. These results are obtaine...

  17. Chemostat modeling of Escherichia coli persistence in conventionalized mono-associated and streptomycin-treated mice

    DEFF Research Database (Denmark)

    Rang, C.; Midtvedt, T.; Molin, Søren;

    2001-01-01

    the decrease in colony counts, we analyzed our previous results by a chemostat model. The analysis shows that the increasing doubling time alone is sufficient to explain the decrease in colony counts in mono- associated mice, but not in the streptomycin-treated mice. The observed decreasing rate in colony...... counts in streptomycin- treated mice is slower than predicted. Furthermore, whereas the model predicted a decrease to extinction in both mice, the E. coli persist at a frequency 10-80 times higher in streptomycin- treated mice than in mono-associated mice. Thus, while a chemostat model is able to explain...

  18. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  19. Communication: Linking the dielectric Debye process in mono-alcohols to density fluctuations

    Science.gov (United States)

    Hecksher, Tina

    2016-04-01

    This work provides the first direct evidence that the puzzling dielectric Debye process observed in mono-alcohols is coupled to density fluctuations. The results open up for an explanation of the Debye process within the framework of conventional liquid-state theory. The spectral shape of the dynamical bulk modulus of the two studied mono-alcohols, 2-ethyl-1-hexanol and 4-methyl-3-heptanol, is nearly identical to that of their corresponding shear modulus, and thus the supramolecular structures believed to be responsible for the slow dielectric Debye process are manifested in the bulk modulus in the same way as in the shear modulus.

  20. The Mono Lake geomagnetic excursion recorded in loess: Its application as time marker and implications for its geomagnetic nature

    Science.gov (United States)

    Hambach, U.; Hark, M.; Zeeden, C.; Reddersen, B.; Zöller, L.; Fuchs, M.

    2009-04-01

    One of the youngest and worldwide documented geomagnetic excursions in the Brunhes Chron is the Mono Lake excursion (MLE). It has been detected in marine and terrestrial sedimentary archives as well as in lavas. Recent age determinations and age estimates for the MLE centre around an age interval of approximately 31 - 34 ka. Likewise the Laschamp excursion the MLE goes along with a distinct peak in cosmogenic radionuclides in ice cores and sedimentary archives. It provides therefore an additional geomagnetic time marker for various geoarchives to synchronise different climate archives. Here we report on a detailed record of the MLE from a loess site at Krems, Lower Austria. The site is situated on the southern slope of the Wachtberg hill in the vicinity of the old city centre of Krems. The archive comprises Middle to Upper Würmian (Late Pleistocene) loess in which an Upper Palaeolithic (Early Gravettian) cultural layer is embedded. The most spectacular finds are a double infant burial found in 2005 and a single burial discovered in 2006 (Einwögerer et al., 2006). Generally, archaeological findings show an extraordinarily good preservation due to embedding in rapidly sedimented loess (Händel et al., 2008). The about 10 m thick loess pile consists of calcareous sandy, coarse silt which is rich in mica indicating local sources. It is well stratified with brownish horizons representing embryonic soils pointing to incipient pedogenesis. Some of the pedo-horizons show occasionally indications of minor erosion and bedding-parallel sediment transport, but no linear erosional features. Pale greyish horizons are the result of partial gleying under permafrost conditions. No strong pedogenesis including decalcification and clay formation is present. The cultural layer is still covered by more than 5 m of loess, and dated by radiocarbon to ~27 ka 14C BP (Einwögerer et al., 2006). Below this layer up to 2.5 m of loess resting on Lower Pleistocene fluvial gravels are

  1. Influência do treinamento aeróbio e anaeróbio na massa de gordura corporal de adolescentes obesos Influencia del entrenamiento aeróbico y anaeróbico en la masa grasa corporal de adolescentes obesos Influence of the aerobic and anaerobic training on the body fat mass in obese adolescents

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Fernandez

    2004-06-01

    Full Text Available O objetivo deste estudo foi verificar as influências do exercício aeróbio e anaeróbio na composição corporal de adolescentes obesos do sexo masculino. A amostra foi constituída de 28 adolescentes com idades entre 15 e 19 anos, que apresentavam obesidade grave. Os voluntários foram distribuídos aleatoriamente em três grupos: grupo I: exercício anaeróbio; grupo II: exercício aeróbio; e grupo III: controle. O grupo I realizou treinamento intervalado em cicloergômetro que consistiu de 12 "tiros" de 30" com máxima força e velocidade, pedalando com carga alta (0,8% do massa corporal x 25 watts e recuperação ativa de 3'; o grupo II realizou treinamento aeróbio em cicloergômetro pedalando com carga relativa ao limiar ventilatório por 50 minutos. Já o terceiro grupo funcionou como controle, sem atividade física. Todos os grupos tiveram orientação nutricional e o período de intervenção foi de 12 semanas (três meses. Os voluntários realizaram densitometria óssea com análise da composição corporal (DEXA e avaliações médicas e de aptidão física. Quando comparados os períodos inicial e final de intervenção foram observadas reduções nas variáveis massa corporal, IMC, na massa de gordura corporal total e de membros inferiores e na percentagem de gordura corporal de tronco nos grupos de exercício. Diferenças foram observadas entre os grupos I e III para os deltas percentuais de massa de gordura corporal total e de membros inferiores e na percentagem de gordura de membros inferiores. Os dados sugerem que o exercício físico, tanto aeróbio como anaeróbio, aliado à orientação nutricional, promove maior redução ponderal, quando comparado com a orientação nutricional somente, e que, neste estudo, o exercício anaeróbio foi mais eficiente para promover a diminuição da gordura corporal e da percentagem de gordura e o exercício aeróbio foi mais eficaz no sentido de preservar e/ou aumentar a massa magra e a

  2. Three-Dimensional Analysis of dike/fault interaction at Mono Basin (California) using the Finite Element Method

    Science.gov (United States)

    La Marra, D.; Battaglia, M.

    2013-12-01

    Mono Basin is a north-trending graben that extends from the northern edge of Long Valley caldera towards the Bodie Hills and is bounded by the Cowtrack Mountains on the east and the Sierra Nevada on the west. The Mono-Inyo Craters volcanic chain forms a north-trending zone of volcanic vents extending from the west moat of the Long Valley caldera to Mono Lake. The Hartley Springs fault transects the southern Mono Craters-Inyo Domes area between the western part of the Long Valley caldera and June Lake. Stratigraphic data suggest that a series of strong earthquakes occurred during the North Mono-Inyo eruption sequence of ~1350 A.D. The spatial and temporal proximity between Hartley Springs Fault motion and the North Mono-Inyo eruption sequence suggests a possible relation between seismic events and eruptions. We investigate the interactions between slip along the Hartley Springs fault and dike intrusion beneath the Mono-Inyo craters using a three-dimensional finite element model of the Mono Basin. We employ a realistic representation of the Basin that includes topography, vertical and lateral heterogeneities of the crust, contact relations between fault planes, and a physical model of the pressure required to propagate the dike. We estimate (a) the distribution of Coulomb stress changes to study the influence of dike intrusion on Hartley Springs fault, and (b) the local stress and volumetric dilatation changes to understand how fault slip may influence the propagation of a dike towards the surface.

  3. Polyurethane triblock copolymers with mono-disperse hard segments. Influence of the hard segment length on thermal and thermomechanical properties

    NARCIS (Netherlands)

    Arun, Araichimani; Baack, Kasper K.J.; Gaymans, Reinoud J.

    2008-01-01

    Polyurethane triblock copolymers were synthesized by reacting 4,4-methylenebis(phenyl isocyanate) (MDI)-endcapped poly(tetramethylene oxide) (PTMO) with mono-amine-amide (MMA) units. Four different MMA units were used, i.e. no-amide (6m), mono-amide (6B), di-amide (6T6m) and tri-amide (6T6B), based

  4. The effect of trace element addition to mono-digestion of grass silage at high organic loading rates.

    Science.gov (United States)

    Wall, David M; Allen, Eoin; Straccialini, Barbara; O'Kiely, Padraig; Murphy, Jerry D

    2014-11-01

    This study investigated the effect of trace element addition to mono-digestion of grass silage at high organic loading rates. Two continuous reactors were compared. The first mono-digested grass silage whilst the second operated in co-digestion, 80% grass silage with 20% dairy slurry (VS basis). The reactors were run for 65weeks with a further 5weeks taken for trace element supplementation for the mono-digestion of grass silage. The co-digestion reactor reported a higher biomethane efficiency (1.01) than mono-digestion (0.90) at an OLR of 4.0kgVSm(-3)d(-1) prior to addition of trace elements. Addition of cobalt, iron and nickel, led to an increase in the SMY in mono-digestion of grass silage by 12% to 404LCH4kg(-1)VS and attained a biomethane efficiency of 1.01. PMID:25280042

  5. Synthesis of lanthanum tris (mono-i-octyl phthalate)and its thermal stability for polyvinyl chloride

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A novel type of thermal stabilizer-lanthanum tris (mono-i-octyl phthalate) (LTMP) was synthesized by double-decomposition reaction of sodium mono-i-octyl phthalate with lanthanum chloride at 60℃.Sodium mono-i-octyl phthalate was prepared by sodium hydrate and mono-i-octyl phthalate prepared by reaction of isooctyl alcohol and phthalic anhydride in the presence of sulfuric acid catalyst at 110 ℃. The yield of lanthanum tris (mono-i-octyl phthalate) is about 84.5%. Its thermal stabilities were measured by heat-ageing oven test when incorporated into PVC. The experimental results show that the heat stability time is about 40min at 190 ℃ when adding 3phr (per hundred resin) to PVC. The thermal stability of this product is better than that of Ca-Zn complex and basic lead salt stabilizers, and equal to that of dibutyltin dilaurate.

  6. Upgrading of the Mono Media Filters in Water Treatment Plants by Changing Filter Media

    Directory of Open Access Journals (Sweden)

    L Rezaei

    2011-01-01

    Full Text Available "n "n "nBackground and Objectives:Dual media filters have two different layer beds consist of sand and Anthracite. Advantage of dual media filters is longer run duration and more filtration rate. The purpose of this study was to achieve a performable model to improve single media Filters in water treatment plants."nMaterials and Methods: in this cross-sectional study, two pilots; mono and dual media were made and in a 5 month period samples taking were done. Total samples taken from input and output of each pilot, was 40. The samples then introduced for the measurment of turbidity and total organic carbon. Meanwhile the filters head loss also quantified in 40 times head loss measurement was done."nResults: Average turbidity removal in mono and two layer pilots were 63 and 65 percent respectively. Average removal of Total Organic Carbon in mono and two media pilots were 40 and 66 percent respectively. Head loss in dual and single media pilots were 0 .68 and 1.15 m respectively."nConclusion: Although average torbidity removal disparity between two pilots was not significant the amount of total organic carbon removed was considerable. Average head loss in single media pilot was more than dual media type. Ratio of UFRV in dual media to mono media filter was 51:30 it shows that filtration rate capacity will be improved up to70 percent by changing media type.

  7. Chromatographic separation and characterization of mono-, di- and triaromatic hydrocarbons in gas oil

    Energy Technology Data Exchange (ETDEWEB)

    Rashid, H.A.; Fakhri, N.A.; Dekran, S.B.; Abdulla, N.I.

    1989-04-01

    A simple procedure is described for separation of aromatic hydrocarbons into mono-, di- and trinuclear types in Iraqi gas oil. This is accomplished by elution through an alumina adsorption column under standardized conditions. Characterization is performed by UV-absorption and ratio matching method. The method can be used also for investigating aromatic hydrocarbon structures of other petroleum fractions.

  8. Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    Pharmaceutical products containing proteins cause problems in testing for endotoxin and pyrogens. Many proteins interfere with the LAL test and the proteins are immunogenic in rabbits. The monocytic cell line Mono Mac 6 is an alternative assay for detection of endotoxin and other pyrogens....

  9. Síntesis de mono y diitaconatos de alquilo y arilo

    Directory of Open Access Journals (Sweden)

    Francisco J. Sánchez

    2011-10-01

    Full Text Available Se presenta una técnica para la síntesis en laboratorio de mono y diitaconatos y la separación de los mismos por extracción selectiva con solventes orgánicos. La pureza de los productos se determina por cromatografía en capa fina y por espectroscopia infrarroja.

  10. One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX

    Directory of Open Access Journals (Sweden)

    Stöcklein Walter

    2007-08-01

    Full Text Available Abstract Background As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small compounds, proteins and rarely even to complete pathogen particles. Most aptamers were isolated from complex libraries of synthetic nucleic acids by a process termed SELEX based on several selection and amplification steps. Here we report the application of a new one-step selection method (MonoLEX to acquire high-affinity DNA aptamers binding Vaccinia virus used as a model organism for complex target structures. Results The selection against complete Vaccinia virus particles resulted in a 64-base DNA aptamer specifically binding to orthopoxviruses as validated by dot blot analysis, Surface Plasmon Resonance, Fluorescence Correlation Spectroscopy and real-time PCR, following an aptamer blotting assay. The same oligonucleotide showed the ability to inhibit in vitro infection of Vaccinia virus and other orthopoxviruses in a concentration-dependent manner. Conclusion The MonoLEX method is a straightforward procedure as demonstrated here for the identification of a high-affinity DNA aptamer binding Vaccinia virus. MonoLEX comprises a single affinity chromatography step, followed by subsequent physical segmentation of the affinity resin and a single final PCR amplification step of bound aptamers. Therefore, this procedure improves the selection of high affinity aptamers by reducing the competition between aptamers of different affinities during the PCR step, indicating an advantage for the single-round MonoLEX method.

  11. Preparation of mono- and diacetyl 4,4′-dimethylbiphenyl and their corresponding carboxylic acids

    DEFF Research Database (Denmark)

    Titinchi, Salam J.J.; Kamounah, Fadhil S.; Abbo, Hanna S.

    2007-01-01

    Shape selective acetylation of 4,4′-dimethylbiphenyl using anhydrous aluminum chloride as catalyst is an effective route for the production of mono- and di-acetyl-4,4′-dimethylbiphenyl. Preparations, characterization and a catalytic study of the Friedel-Crafts acetylation of 4,4′-dimethylbiphenyl...

  12. De kwalitatieve en semikwantitatieve bepaling van 6-mono-acetylmorfine in de urine van druggebruikers (I)

    NARCIS (Netherlands)

    Derks HJGM; van Twillert K; Zomer G

    1984-01-01

    In dit rapport wordt een analytische methode beschreven voor de bepaling van 6-mono-acetylmorfine in urine. Deze metaboliet van heroine is een marker voor heroine-gebruik en de bepaling ervan kan gebruikt worden om het gebruik van heroine van dat van morfine te onderscheiden. De methode is gebasee

  13. A study on synthesis and oxidation mechanism of mono-alkyl phosphate

    Institute of Scientific and Technical Information of China (English)

    Sheng Wang; Shu-yun Yan; Qing-guo Ye

    2009-01-01

    Oxidation of white phosphor, us by peroxides to produce mono-alkyl phosphate in the alcoholic solution has been studied under non-and catalytic conditions. In this paper, the mechanism of the oxidation process was analyzed. The content of mono-alkyl phosphalte in the product is affected by different types of alcoholic solution and peroxide solvent. The result shows the availabulity of the following order for the activity of the peroxide solvent and alcoholic solutions-tert-butyl hydroperoxide>(di) benzoyl peroxide>hydroperoxide; methanol> n-butyl alcohol> phenol. Under optimized reaction conditions: n (a white phosphorus) : n( tert-butyl hydroperoxide) : n (methanol)= 1:10:12, reaction temperature 80 ℃, reaction time 2.5 h, products of 80.0% mono-alkyl phosphonates can be provided when white phosphorus undergoes oxidation by tert-butyl hydroperoxide in the methanol solutions. When Cu (I), and Cn(Ⅱ) complexes are used as catalysts, it is possible to significantly enhance the oxidation of white phosphorus with the increase in the reaction rate. Th'e order for activity of catalysts is Cu(acac)2>Cu (CH3COO)2>Cu (C3 H7COO)2:>CuI>CuCI2. Noticeably, with Cu(acac)2 as catalyst, the selectivity for mono-alkyl phusphonates can reach 95% under adequate reaction conditions.

  14. Synthesis of hierarchical zeolites using an inexpensive mono-quaternary ammonium surfactant as mesoporogen.

    Science.gov (United States)

    Zhu, Xiaochun; Rohling, Roderigh; Filonenko, Georgy; Mezari, Brahim; Hofmann, Jan P; Asahina, Shunsuke; Hensen, Emiel J M

    2014-12-01

    A simple amphiphilic surfactant containing a mono-quaternary ammonium head group (N-methylpiperidine) is effective in imparting substantial mesoporosity during synthesis of SSZ-13 and ZSM-5 zeolites. Highly mesoporous SSZ-13 prepared in this manner shows greatly improved catalytic performance in the methanol-to-olefins reaction compared to bulk SSZ-13. PMID:25316609

  15. 77 FR 71611 - Land Acquisitions; North Fork Rancheria of Mono Indians of California

    Science.gov (United States)

    2012-12-03

    ... Bureau of Indian Affairs Land Acquisitions; North Fork Rancheria of Mono Indians of California AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice of final agency determination. SUMMARY: The Assistant Secretary--Indian Affairs made a final agency determination to acquire approximately 305.49 acres of land...

  16. Synthesis and photochromic behavior of mono-,and biphotochromic system linked by p-phenylene bridge

    Institute of Scientific and Technical Information of China (English)

    N.O.Mahmoodi; K.Tabatabaeian; A.Ghavidast

    2010-01-01

    The synthesis of mono- and bis-1,3-diazabicyclo[3.1.0]hex-3-ene derivatives with indole ring and p-phenylene spacer,which behave as photochromic materials,is reported.The structure-photochromic behavior relationship (SPBR) of the synthesized compounds has been analyzed.

  17. Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome in mice

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper;

    Mono-colonization of germ-free (GF) mice enables the study of specific bacterial species in vivo. Lactobacillus acidophilus is a probiotic strain, however many of the mechanisms behind its health-promoting effect remain unsolved. Here, we studied the effects of Lactobacillus acidophilus NCFMTM...

  18. Mechanism-specific and whole-organism ecotoxicity of mono-rhamnolipids.

    Science.gov (United States)

    Johann, Sarah; Seiler, Thomas-Benjamin; Tiso, Till; Bluhm, Kerstin; Blank, Lars M; Hollert, Henner

    2016-04-01

    Biosurfactants like rhamnolipids are promising alternatives to chemical surfactants in a range of applications. A wider use requires an analysis of their environmental fate and their ecotoxicological potential. In the present study mono-rhamnolipids produced by a recombinant Pseudomonas putida strain were analyzed using the Green Toxicology concept for acute and mechanism-specific toxicity in an ecotoxicological test battery. Acute toxicity tests with the invertebrate Daphnia magna and with zebrafish embryos (Danio rerio) were performed. In addition, microbial and fungicidal effectiveness was investigated. Mutagenicity of the sample was tested by means of the Ames fluctuation assay. A selected mono-rhamnolipid was used for model simulations regarding mutagenicity and estrogenic activity. Our results indicate that mono-rhamnolipids cause acute toxicity to daphnids and zebrafish embryos comparable to or even lower than chemical surfactants. Rhamnolipids showed very low toxicity to the germination of Aspergillus niger spores and the growth of Candida albicans. No frameshift mutation or base substitutions were observed using the Ames fluctuation assay with the two tester strains TA98 and TA100. This result was confirmed by model simulations. Likewise it was computed that rhamnolipids have no estrogenic potential. In conclusion, mono-rhamnolipids are an environmental friendly alternative to chemical surfactants as the ecotoxicological potential is low. PMID:26802344

  19. The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats

    DEFF Research Database (Denmark)

    Dalgaard, M.; Nellemann, Christine Lydia; Lam, Henrik Rye;

    2001-01-01

    A single oral dose of 400 mg/kg body weight of mono(2-ethylhexyl)phthalate (MEHP), the testis toxic metabolite of di(2-ethylhexyl)phthalate. was given to 28-day-old male Wistar rats and the testis toxic effects were investigated 3, 6. and 12 h after exposure. Detachment and sloughing of germ cell...

  20. Analysis of fae and fhcD Genes in Mono Lake, California

    OpenAIRE

    Nercessian, Olivier; Kalyuzhnaya, Marina G.; Joye, Samantha B.; Lidstrom, Mary E.; Chistoserdova, Ludmila

    2005-01-01

    Genes for two enzymes of the tetrahydromethanopterin-linked C1 transfer pathway (fae and fhcD) were detected in hypersaline, hyperalkaline Mono Lake (California), via PCR amplification and analysis. Low diversity for fae and fhcD was noted, in contrast to the diversity previously detected in a freshwater lake, Lake Washington (Washington).

  1. Synthesis of Versatile Building Blocks through Asymmetric Hydrogenation of Functionalized Itaconic Acid Mono-Esters

    NARCIS (Netherlands)

    Hekking, Koen F.W.; Lefort, Laurent; Vries, André H.M. de; Delft, Floris L. van; Schoemaker, Hans E.; Vries, Johannes G. de; Rutjes, Floris P.J.T.

    2008-01-01

    The rhodium-catalyzed asymmetric hydrogenation of several β-substituted itaconic acid mono-esters, using a library of monodentate phosphoramidite and phosphite ligands is described. Two β-alkyl-substituted substrates were readily hydrogenated by the rhodium complex Rh(COD)2BF4 in combination with (S

  2. Maillard reaction products of rice protein hydrolysates with mono-, oligo- and polysaccharides

    Science.gov (United States)

    Rice protein, a byproduct of rice syrup production, is abundant but, its lack of functionality prevents its wide use as a food ingredient. Maillard reaction products of (MRPs) hydrolysates from the limited hydrolysis of rice protein (LHRP) and various mono-, oligo- and polysaccharides were evaluat...

  3. MONO-PULSE RADAR 3-D IMAGING TECHNIQUES FOR TARGET IN STEPPED TRACKING MODE

    Institute of Scientific and Technical Information of China (English)

    Zhang Tao; Ma Changzheng; Zhang Qun; Zhang Shouhong

    2002-01-01

    A method for mono-pulse radar 3-D imaging in stepped tracking mode is presented and the amplitude linear modulation of error signals in stepped tracking mode is analyzed with its compensation method followed, so the problem of precisely tracking of target is solved. Finally the validity of these methods is proven by the simulation results.

  4. Emotions in freely varying and mono-pitched vowels, acoustic and EGG analyses.

    Science.gov (United States)

    Waaramaa, Teija; Palo, Pertti; Kankare, Elina

    2015-12-01

    Vocal emotions are expressed either by speech or singing. The difference is that in singing the pitch is predetermined while in speech it may vary freely. It was of interest to study whether there were voice quality differences between freely varying and mono-pitched vowels expressed by professional actors. Given their profession, actors have to be able to express emotions both by speech and singing. Electroglottogram and acoustic analyses of emotional utterances embedded in expressions of freely varying vowels [a:], [i:], [u:] (96 samples) and mono-pitched protracted vowels (96 samples) were studied. Contact quotient (CQEGG) was calculated using 35%, 55%, and 80% threshold levels. Three different threshold levels were used in order to evaluate their effects on emotions. Genders were studied separately. The results suggested significant gender differences for CQEGG 80% threshold level. SPL, CQEGG, and F4 were used to convey emotions, but to a lesser degree, when F0 was predetermined. Moreover, females showed fewer significant variations than males. Both genders used more hypofunctional phonation type in mono-pitched utterances than in the expressions with freely varying pitch. The present material warrants further study of the interplay between CQEGG threshold levels and formant frequencies, and listening tests to investigate the perceptual value of the mono-pitched vowels in the communication of emotions. PMID:24998780

  5. Production of pulse in mono-cropped rice system in the coastal region of Eastern India

    International Nuclear Information System (INIS)

    This experiment was undertaken with an objective to increase the yield of black-gram leguminous pulse crop through optimal doses of phosphatic fertilizer with supplemental irrigation in mono-cropped rice-fallow regions of India. Irrigation and phosphorus fertilizer application were introduced for enhancing productivity of black-gram to provide better returns to available water resources

  6. Prevenção da síndrome metabólica em crianças obesas: uma proposta de intervenção Prevención del síndrome metabólico en niños obesos: una propuesta de intervención Prevention of metabolic syndrome in obese children: a proposal of intervention

    Directory of Open Access Journals (Sweden)

    Camila Buonani

    2011-06-01

    Full Text Available OBJETIVO: Analisar o efeito de 12 semanas de intervenção envolvendo prática de atividade física, orientações alimentar e psicológica sobre fatores de risco para o desenvolvimento da síndrome metabólica em crianças e adolescentes obesos. MÉTODOS: Estudo longitudinal com 23 crianças e adolescentes obesos, com idade entre seis e 16 anos (12,0±3,2 anos. Foram mensurados: gordura corporal total e de tronco, glicemia, colesterol total e triglicérides, pressão arterial sistólica e diastólica. Os jovens foram submetidos a três sessões semanais de 60 minutos de exercício físico (atividades esportivas recreativas, ginástica, circuitos e caminhadas, durante 12 semanas. O teste do qui-quadrado foi usado para comparar dados categóricos daqueles que apresentaram valores acima das recomendações para cada fator de risco. O teste t para dados pareados foi aplicado para comparar os dois momentos do estudo. RESULTADOS: Em indivíduos com alterações metabólicas no início do estudo, observou-se, após a intervenção, a diminuição de 11,6% na glicemia (105 para 93mg/dL; p=0,046 e de 24,9% no triglicérides (217 para 163mg/dL; p=0,013; porém, não houve diferenças na pressão arterial e no colesterol total. CONCLUSÕES: O programa de exercício físico aplicado nas crianças e adolescentes foi eficiente para melhorar os valores de glicemia e triglicérides.OBJETIVO: Analizar el efecto de 12 semanas de intervención implicando práctica de actividad física, orientación alimentar y psicológica sobre factores de riesgo respecto al desarrollo del síndrome metabólico en niños y adolescentes obesos. MÉTODOS: Estudio longitudinal con 23 niños y adolescentes obsesos, con edad entre seis y 16 años (12,0±3,2 años. Se midió: grasa corporal total y de tronco, glucemia, colesterol total y triglicéridos, presión arterial sistólica y diastólica Los jóvenes fueron sometidos a tres sesiones semanales de 60 minutos de ejercicio f

  7. Assessment of SRTM for studies of deformed lake terraces, Mono Basin, CA, USA

    Science.gov (United States)

    Breier, P.; Bursik, M.; Webb, F.

    2003-04-01

    Mono Lake lies east of the Sierra Nevada, central California, USA. Late Quaternary transgressions and regressions of Mono Lake have produced well-defined terraces within the active and relict shorelands of Mono Basin, as well as on the islands within the lake, including the largest, Paoha Island. To assess the ability of SRTM data to resolve the terraces, we compared the SRTM data to TOPSAR data along topographic profiles. The accuracy of the profiles was assessed by visual and statistical comparison. Information was then extracted from the profiles to determine whether the terraces showed any evidence of warping or offset. Perhaps the most prominent terraces within the basin lie on the eastern and western sides of Paoha Island. When compared with the TOPSAR profiles across these terraces, SRTM profiles are systematically smoother and higher. Comparison of a running average of the TOPSAR data as well as TOPSAR data decimated to 30 m with the SRTM data suggests that much of the SRTM smoothness is the result of the 30 m spacing of the SRTM data as opposed to the 5 m spacing of the TOPSAR data. There is however a mean vertical difference observed between the SRTM and TOPSAR datasets that averages approximately 5 m over a large part of the basin. Near the tops of hills and ridges, the difference between the datasets is less than it is over depressions or areas of low relief. We are investigating the potential causes of the systematic difference. We are exploring the SRTM and TOPSAR data to understand their suitability for determination of deformation of shoreline features. In particular, we are interested in whether magmatic activity beneath the Mono Craters, a volcanic chain on the southern margin of Mono Lake, may be responsible for deformation of a latest Pleistocene(?) terrace at a nominal elevation of 1990 m. The elevation of the bluff-berm break in slope for this terrace was estimated to be at the point of maximum curvature in topographic profiles crossing the

  8. High-resolution aeromagnetic survey of the Mono Basin-Long Valley Caldera region, California

    Science.gov (United States)

    Ponce, D. A.; Mangan, M.; McPhee, D.

    2013-12-01

    A new high-resolution aeromagnetic survey of the Mono Basin-Long Valley Caldera region greatly enhances previous magnetic interpretations that were based on older, low-resolution, and regional aeromagnetic data sets and provides new insights into volcano-tectonic processes. The surveyed area covers a 8,750 km2 NNW-trending swath situated between the Sierra Nevada to the west and the Basin and Range Province to the east. The surveyed area includes the volcanic centers of Mono Lake, Mono-Inyo Craters, Mammoth Mountain, Devils Postpile, and Long Valley Caldera. The NW-trending eastern Sierra frontal fault zone crosses through the study area, including the active Mono Lake, Silver Lake, Hartley Springs, Laurel Creek, and Hilton Creek faults. Over 6,000 line-kilometers of aeromagnetic data were collected at a constant terrain clearance of 150 m, a flight-line spacing of 400 m, and a tie-line spacing of 4 km. Data were collected via helicopter with an attached stinger housing a magnetic sensor using a Scintrex CS-3 cesium magnetometer. In the northern part of the survey area, data improve the magnetic resolution of the individual domes and coulees along Mono Craters and a circular shaped magnetic anomaly that coincides with a poorly defined ring fracture mapped by Kistler (1966). Here, aeromagnetic data combined with other geophysical data suggests that Mono Craters may have preferentially followed a pre-existing plutonic basement feature that may have controlled the sickle shape of the volcanic chain. In the northeastern part of the survey, aeromagnetic data reveal a linear magnetic anomaly that correlates with and extends a mapped fault. In the southern part of the survey, in the Sierra Nevada block just south of Long Valley Caldera, aeromagnetic anomalies correlate with NNW-trending Sierran frontal faults rather than to linear NNE-trends observed in recent seismicity over the last 30 years. These data provide an important framework for the further analysis of the

  9. Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru.

    Directory of Open Access Journals (Sweden)

    Leonela Villegas

    Full Text Available Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes.A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Löwenstein-Jensen (LJ media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment.Of 1292 patients enrolled, 1039 (80% were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8% patients and rifampicin mono-resistance was present in 24 (2% patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR = 2.10; 95% confidence interval (CI: 1.1-4.1, and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95%CI: 1.9-47.8. Isoniazid mono-resistant patients had a higher risk of poor treatment outcomes including treatment failure (2/85, 2%, p-value<0.01 and death (4/85, 5%, p<0.02. Rifampicin mono-resistant patients had a higher risk of death (2/24, 8%, p<0.01.A high prevalence of isoniazid and rifampicin mono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes.

  10. A new approach to modelling and designing mono-block dental implants

    Directory of Open Access Journals (Sweden)

    R. Hunter

    2007-05-01

    Full Text Available Purpose: of this paper is present a new approach to modelling and design the low cost mono-block dental implants based on the integration of the computer aided techniques. This approach provides the automation of the design process of the mono-block dental implants.Design/methodology/approach: The approach used to develop the modelling and design of the mono-block dental implants are based on the parametrization of the main geometric features of the implants. This approach allows to generate several designs of the implant with different configurations respect to the dimensions, forms and tolerances.Findings: The findings are focused on two main topics. The first one is the minimization of the manufacturing cost and time based on the manufacture process automation. The second one is the integration, in the same informatics platform, of the design, analysis and manufacturing environment.Research limitations/implications: The implications are focused on the development of a new design of mono-block dental implants. One of the main features of this design is associated to the reduction of the surgical stage and their simplification respect to other commercial implants.Practical implications: The main outcomes and implications of this research is the design of a low cost dental implant. This solution is implemented to assist the social programs of oral health.Originality/value: The originality of this research is the design of a new model of mono-block dental implant. The structure of this implant improves the mechanical properties; reduce the manufacturing cost and the surgical complications.

  11. AL Amyloidosis

    Directory of Open Access Journals (Sweden)

    Desport Estelle

    2012-08-01

    Full Text Available Abstract Definition of the disease AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig light chains (LC (most commonly of lambda isotype usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multiple myeloma or other B-cell lymphoproliferative disorders is unusual. The key event in the development of AL amyloidosis is the change in the secondary or tertiary structure of an abnormal monoclonal LC, which results in instable conformation. This conformational change is responsible for abnormal folding of the LC, rich in β leaves, which assemble into monomers that stack together to form amyloid fibrils. Epidemiology AL amyloidosis is the most common type of systemic amyloidois in developed countries with an estimated incidence of 9 cases/million inhabitant/year. The average age of diagnosed patients is 65 years and less than 10% of patients are under 50. Clinical description The clinical presentation is protean, because of the wide number of tissues or organs that may be affected. The most common presenting symptoms are asthenia and dyspnoea, which are poorly specific and may account for delayed diagnosis. Renal manifestations are the most frequent, affecting two thirds of patients at presentation. They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients. Heart involvement, which is present at diagnosis in more than 50% of patients, leading to restrictive cardiopathy, is the most serious complication and engages prognosis. Diagnostic methods The diagnosis relies on pathological examination of an involved site showing Congo red-positive amyloid deposits, with typical apple-green birefringence under polarized light, that stain positive with an anti-LC antibody by immunohistochemistry and

  12. Humanos salvajes y monos altruistas. Reflexiones sobre Darwin

    Directory of Open Access Journals (Sweden)

    Martinez Contreras Jorge

    2009-12-01

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    RESUMEN

     

    Darwin propuso en 1871 que preferiría descender de un mono que de los “salvajes”. El mono es un babuino hamadryas que, en un relato de Brehm, salva a un infante de una jauría. Los “salvajes” son los fueguinos a los que visitó en los años 1830. ¿Por qué Darwin fue tan buen observador del comportamiento animal y por qué no dudo discernir en qué consistía la sociedad de cazadores-recolectores de los cuatro grupos de Tierra del Fuego?. Esto es lo que tratamos de dilucidar en este trabajo.

     

  13. Radiocarbon constraints on fossil thinolite tufa formation in the Mono Basin, CA, USA

    Science.gov (United States)

    Leroy, S. L.; Zimmerman, S. R.; Hemming, S. R.; Stine, S.; Guilderson, T. P.

    2009-12-01

    Mono Lake is a terminal lake located at the western edge of the Great Basin, and is famous for its tufa towers. Thinolite, which is thought to be a CaCO3 pseudomorph of ikaite, is found around the Mono Basin in many fossil tufa towers, particularly at elevations above 2000 meters. The subaqueous parent mineral ikaite forms at low temperatures (Mono Basin has yielded a rather small range of ages for the highest elevation towers, between 11.8 and 14.1 14C kyr BP (no corrections for reservoir effects have been made). A thinolite fan collected from outcrops in Mill Creek, just north of the current Mono Lake yielded an age of 10,690 ± 45 14C yr BP (12,750 ± 80 cal yr BP), consistent with a ca. 1000 year reservoir age and coincidence with thinolite crystals found in a core from the northwestern embayment of Mono Lake (Davis, 1999, QR), and thus correlating with the Younger Dryas cooling event as exhibited in the GISP2 δ18O record. While most of the thinolite textures are found at high elevations, we sampled a mound at 1955 meters (near the current shoreline, north of the lake and just east of Black Point) that has many concentric layers, some containing thinolite textures. Although tufa mounds can form very rapidly, the location at low elevation and the presence of at least 19 distinct layers led us to consider that this mound might represent a long term record of Mono Lake’s chemistry. The new data confirm that the mound formed over a long period within the last glacial cycle, with ages ranging beyond the current limits of measurement (>34 kyr) to as young as 15.5 14C kyr BP. In general there is a consistent stratigraphic trend of ages within the mound, but the thinolite ages are anomalously young and one thinolite sample shows a large age reversal. The best estimate of the age of the precipitation of this tufa mound is given by the non-thinolite textures. More work is needed to determine the best sampling and sample preparation strategies in order to get a

  14. 1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  15. 1. Mono((8)annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono((8)annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono((8)annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  16. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    Full Text Available FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo Modelo de Avaliação da Homeostase (HOMA-RI: com resistência insulínica (RI n = 39 e sem resistência insulínica (NRI n = 27, e foram submetidos a uma intervenção interdisciplinar ao longo de um ano. A espessura mediointimal da artéria carótida comum (EMIC, e o tecido adiposo visceral e subcutâneo foram determinados por ultrassonografia. A composição corporal, pressão arterial, índice HOMA-RI, perfil lipídico e as concentrações de adipocinas [leptina, adiponectina, e inibidor do ativador do plasminogênio-1 (PAI-1] foram analisados antes e após a terapia. RESULTADOS: Ambos os grupos apresentaram melhoras significativas na composição corporal, estado inflamatório (redução da concentração de leptina e PAI 1; aumento de adiponectina plasmática e redução da EMIC. Apenas o grupo NRI mostrou correlação positiva entre as alterações na gordura visceral (∆Visceral e mudanças na EMIC (∆ EMIC (r = 0,42, p BACKGROUND: The atherosclerotic process at the endothelial level begins in early ages and seems to be associated with obesity and its comorbidities as insulin resistance. OBJECTIVE: The aim of this study was to verify the influence of insulin resistance on inflammatory and subclinical markers of atherosclerosis in obese adolescents. METHODS: Sixty-six post-pubescent obese adolescents were divided in two groups according to homeostasis model assessment of insulin resistance (HOMA-IR measurement: with insulin resistance

  17. Effects of telmisartan vs olmesartan on metabolic parameters, insulin resistance and adipocytokines in hypertensive obese patients Efectos de telmisartan vs olmesartan sobre parámetros antropométricos, resistencia a la insulina y adipocitoquinas en pacientes hipertensos obesos

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2010-04-01

    Full Text Available Background: Angiotensin II regulates the production of adipokines. The objective was to study the effect of treatment with telmisartan versus olmesartan in hypertensiveobese and overweight patients. Subjects: A sample of 65 overweight and obese patients with mild to moderate hypertension was analyzed in a prospective way with a randomized trial. Patients were randomized to telmisartan (80 mg/day or olmesartan (40 mg/day for 3 months. Weight, body mass index, blood pressure, basal glucose, insulin, total cholesterol, LDLcholesterol, HDL-cholesterol, triglycerides, HOMA, QUICKI, leptin and adiponectin were determined at basal time and after 3 months of treatment. Results: Sixty five patients gave informed consent and were enrolled in the study. Patients treated with telmisartan had a significative decrease of glucose 10.53 mg/dl (CI 95%: 2.6-18.5, insulin 2.51 mUI/L (CI 95%: 2.07-7.17 and HOMA 1.08 (CI 95%: 0.39-2.55. Patients treated with olmesartan had a significative decrease of total cholesterol 20.2 mg/dl (CI 95%: 5.8-34.9 and LDL cholesterol 22.6 mg/dl (CI 95%: 9.7-35.6. Only leptin levels have a significant decrease in telmisartan group 7.39 ng/ml (CI 95%: 1.47-13.31. Conclusion: Telmisartan improved blood pressure, glucose, insulin, HOMA and leptin in hypertensive diabetic patients. Olmesartan improved blood pressure and lipid levels.Introducción: La angiotensina II puede regular la producción de adipocitoquinas. El objetivo de nuestro trabajo fue evalaur el efecto sobre parámetros bioquímicos del tratamiento con telmisartan versus olmesartan en pacientes obesos hipertensos. Pacientes: Se analizó una muestra de 65 pacientes con hipertensión moderada severa y obesidad, mediante un ensayo clínico randomizado. Los pacientes fueron randomizados en dos ramas; telmisartan (80 mg/día u olmesartan (40 mg/día durante 3 meses. Se determinaron en el tiempo basal y tras 3 meses los siguientes parámetros; peso, índice de masa corporal, presi

  18. O efeito em curto prazo do bypass gástrico sobre pacientes obesos diabéticos Short-term effect of gastric bypass in obese diabetic patients

    Directory of Open Access Journals (Sweden)

    Aluisio Stoll

    2013-02-01

    Full Text Available OBJETIVO: estudar o efeito do bypass gástrico sobre a glicemia e o uso de medicação antidiabética em pacientes obesos portadores de diabetes. MÉTODOS: estudo de coorte retrospectivo com 44 pacientes obesos portadores de DM2, provenientes de 469 pacientes submetidos ao bypass gástrico no período de dezembro de 2001 a março de 2009. Os desfechos primários avaliados foram: glicemia em jejum e a necessidade de medicação antidiabética. RESULTADOS: a população foi composta de dez (22,7% homens e 34 (77,3% mulheres, com média de idade de 45,3 (±8,23 anos e índice de massa corporal de 40,9 (±5,03 kg/m². O tempo médio de evolução do DM2 foi 63,6 (±60,9 meses. Dos 40 pacientes que utilizavam medicação para controle do DM2, 20 (50% tiveram sua medicação suspensa na alta hospitalar e 13 (32,5% até nove meses depois. Em uma paciente não foi possível avaliar o uso de medicação, sendo essa a única exclusão. A insulina foi suspensa nos dez (100% pacientes que a utilizavam, sendo seis (60% na alta hospitalar. Houve redução (POBJECTIVE: To study the effect of gastric bypass on blood glucose levels and the use of antidiabetic medication in obese patients with diabetes. METHODS: We carried out a retrospective cohort study with 44 obese patients with DM2, from 469 patients undergoing gastric bypass from December 2001 to March 2009. The primary endpoints evaluated were fasting glucose and the need for antidiabetic medication. RESULTS: The study population consisted of ten (22.7% men and 34 (77.3% women, with a mean age of 45.3 (±8.23 years and a body mass index of 40.9 (±5.03 kg/m². The average time to progression of DM2 was 63.6 (±60.9 months. Of the 40 patients who used medication to control type 2 diabetes, 20 (50% had their medication discontinued at discharge and 13 (32.5%, until nine months later. In one patient it was not possible to evaluate the use of medication, this being the only exception. Insulin was suspended in

  19. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2 Impact of participatory education on body mass index and blood glucose in obese type-2 diabetics

    OpenAIRE

    Carlos Enrique Cabrera-Pivaral; Guillermo González-Pérez; María Guadalupe Vega-López; Elva Dolores Arias-Merino

    2004-01-01

    La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC) en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos...

  20. Niveles séricos de leptina y su relación con la excreción de sodio en niños y adolescentes obesos Relationship between serum leptin levels and sodium excretion in a local population of obese children and adolescents

    OpenAIRE

    A. Maskin de Jensen; López, M; Mir, C.; MARTÍNEZ M; M. Ibañez de Pianesi; Erhard, M.

    2011-01-01

    La obesidad se asocia con niveles elevados de leptina y la mayoría de los individuos obesos presentan resistencia "selectiva" a su acción metabólica sin disminución del apetito ni aumento en el gasto energético, con preservación y estimulación de la activación del sistema simpático a nivel central y de las acciones periféricas cardiovasculares y renales. Estos mecanismos podrían modificar la regulación del metabolismo del sodio a nivel renal. Objetivo: identificar el comportamiento de los niv...

  1. Abordagem multidisciplinar de pacientes obesos mórbidos submetidos a tratamento cirúrgico pelo método da banda gástrica ajustável Multidisciplinary approach to morbidly obese patients undergoing surgical treatment by adjustable gastric banding

    OpenAIRE

    Denis Pajecki; Mancini, Marcio C; Alfredo Halpern; Bruno Zilberstein; Artur B. Garrido Jr; Ivan Cecconello

    2010-01-01

    OBJETIVO: Avaliar o resultado do tratamento cirúrgico de pacientes obesos mórbidos pelo método da BGA, acompanhados em ambulatório multidisciplinar. MÉTODOS: Foram estudados 20 pacientes com IMC que variou de 36,6 a 72 kg/m2 (X=47,51 +/- 6,1) e idade entre 36 a 60 anos, submetidos à colocação de BGA. As comorbidades encontradas no pré-operatório foram hipertensão arterial (nove), diabetes tipo II (quatro), apneia do sono grave (um), hipertrigliceridemia (quatro) e problemas ortopédicos graves...

  2. Forced vibration and wave propagation in mono-coupled periodic structures

    DEFF Research Database (Denmark)

    Ohlrich, Mogens

    1986-01-01

    This paper describes the wave propagation and vibration characteristics of mono-coupled structures which are of spatially periodic nature. The receptance approach to periodic structure theory is applied to study undamped periodic systems with composite structural elements; particular emphasis...... and a general `closed form' solution is found for the forced harmonic response at element junctions. This `junction-receptance' is used to determine-discrete junction mode shapes of a finite system. Finally, the forced response of a finite structure with an internal obstruction is derived as a natural extension...... is laid on investigating resonant periodic point loading and its pronounced effect on the propagation of longitudinal waves. General mono-coupled periodic systems are first assumed to be infinite in extent; thereafter reflections caused by arbitrary end terminations of finite structures are considered...

  3. Mono-layer BC2 a high capacity anode material for Li-ion batteries

    Science.gov (United States)

    Hardikar, Rahul; Samanta, Atanu; Han, Sang Soo; Lee, Kwang-Ryeol; Singh, Abhishek

    2015-04-01

    Mono-layer of graphene with high surface area compared to the bulk graphite phase, shows less Li uptake. The Li activity or kinetics can be modified via defects and/or substitutional doping. Boron and Nitrogen are the best known dopants for carbonaceous anode materials. In particular, boron doped graphene shows higher capacity and better Li adsorption compared to Nitrogen doped graphene. Here, using first principles density functional theory calculations, we study the spectrum of boron carbide (BCx) mono-layer phases in order to estimate the maximum gravimetric capacity that can be achieved by substitutional doping in graphene. Our results show that uniformly boron doped BC2 phase shows a high capacity of? 1400 mAh/g, much higher than previously reported capacity of BC3. Supported by Korea Institute of Science and Technology.

  4. Rotavirus infection in children: mono-and combines forms, especially clinics and course

    Directory of Open Access Journals (Sweden)

    N. B. Denisyuk

    2012-01-01

    Full Text Available Analyzed 74 case histories of children under one year with rotavirus infection. The most commonly detected rotavirus gastroenteritis in the form of mono-and combined forms. Mono-infection in 78.3% of cases occurred in the moderate form with a leading syndrome in the form of gastroenteritis, severe dehydration proceeded with symptoms of varying severity. Mixed variants in 98.7% of cases are in the unfavorable premorbid background, in 42.8% of children were registered in the severe forms, and children younger than 6 months were erased within. The diagnosis of intestinal infection was confirmed by PCR, bacteriological and immunological methods.

  5. Numerical simulation of stresses and dislocations in quasi-mono silicon

    Science.gov (United States)

    Dadzis, K.; Behnken, H.; Bähr, T.; Oriwol, D.; Sylla, L.; Richter, T.

    2016-09-01

    The Alexander-Haasen model is applied for the analysis of dislocation dynamics in quasi-mono crystalline silicon. Model constants are re-calibrated using stress-strain measurements on small silicon samples under uniaxial compression. It is observed that the activation energy may decrease at low temperatures and the hardening parameter generally increases due to the presence of grown-in dislocation clusters. The calibrated model is applied to an idealized cooling process which allows for a discussion of the basic physical mechanisms leading to residual stresses in quasi-mono ingots. Residual stresses can be reduced by minimizing thermal stresses during the elastic-plastic transition, which was observed approximately between 1100 °C and 750 °C in the present case.

  6. Couple Control Model Implementation on Antagonistic Mono- and Bi-Articular Actuators

    CERN Document Server

    Prattico, Flavio; Yamamoto, Shin-ichiroh

    2014-01-01

    Recently, robot assisted therapy devices are increasingly used for spinal cord injury (SCI) rehabilitation in assisting handicapped patients to regain their impaired movements. Assistive robotic systems may not be able to cure or fully compensate impairments, but it should be able to assist certain impaired functions and ease movements. In this study, a couple control model for lower-limb orthosis of a body weight support gait training system is proposed. The developed leg orthosis implements the use of pneumatic artificial muscle as an actuation system. The pneumatic muscle was arranged antagonistically to form two pair of mono-articular muscles (i.e., hip and knee joints), and a pair of bi-articular actuators (i.e., rectus femoris and hamstring). The results of the proposed couple control model showed that, it was able to simultaneously control the antagonistic mono- and bi-articular actuators and sufficiently performed walking motion of the leg orthosis.

  7. Detection and Quantification of Crack in Composite Mono Leaf Spring by Vibration Parameters

    Science.gov (United States)

    Jamadar, Nagendra Iranna; Kivade, Sangshetty Bheemanna; Pedada, Sudhakara Rao

    2016-06-01

    Automobile industries focus for the components alternative to conventional materials with composites. There is high demand for enhanced performance and light weight. The emphasis is given for composite mono leaf spring as potential item as it is made up of glass fibre reinforced plastics despite they are sensitive to damages such as crack, delamination, de-bonding etc., occurred during either manufacturing or in service condition. These damages grow in progression and results in catastrophic failure. This work aims to deal with structural health monitoring to study and analyse the damage levels in composite mono leaf spring such as detection, location and quantification of damage. An experimental investigation has been carried out to evaluate presence and severity of damage by vibration parameters and validated with simulation.

  8. Resurrecting an unsalvageable lower incisor with a mono-block approach

    Directory of Open Access Journals (Sweden)

    Rachit Jain

    2015-01-01

    Full Text Available Contemporary techniques, as well as the availability of bioactive and adhesive materials in endodontics, have helped revivifying teeth that were deemed hopeless. These newer materials and techniques would enable the clinician: (a to predictably stop microbial activity (b to achieve a total corono-apical fluid tight seal and (c to strengthen mutilated teeth by obtaining intra-radicular reinforcement through mono-block effect. This case report demonstrates the successful treatment of a mutilated anterior tooth with the use of bioactive and adhesive materials to obtain a total seal and mono-block effect. This article also shows the use of a simple method in the placement of root filling cement into the root canal.

  9. Application of k0-based internal mono-standard PGNAA for compositional characterization of cement samples

    International Nuclear Information System (INIS)

    The k0-based internal mono-standard prompt gamma-ray neutron activation analysis (IM-PGNAA) method was used for compositional analysis of a cement standard provided by the International Atomic Energy Agency as a part of inter-laboratory comparison exercise. The PGNAA was also applied to a local cement sample for comparison purpose. The concentration ratios of elements with respect Ca were determined using the internal mono-standard method. The concentration ratios were then converted to the absolute concentrations by determining concentration of Ca in the cement using relative method. Concentrations of 11 elements were determined in both sample and standard of cement. The results of cement standard are found to be in good agreement with the certified values. The uncertainties on the elemental concentrations were in the range of 5-10 %. (author)

  10. Absorption of THz electromagnetic wave in two mono-layers of graphene

    Science.gov (United States)

    Reynolds, Cole B.; Shoufie Ukhtary, M.; Saito, Riichiro

    2016-05-01

    Nearly 100% absorption of an electromagnetic (EM) wave in terahertz (THz) frequency is proposed for a system consisting of two mono-layers of graphene. Here, we demonstrate that the system can almost perfectly absorb an EM wave with frequency of 2 THz, even though we have a low electron mobility of roughly 1000 cm2  Vs‑1. The absorption probability is calculated by using the transfer matrix method. We show that the two mono-layers of the graphene system is needed to obtain nearly 100% absorption when the graphene has a relatively low Fermi energy. The absorption dependence on the distance between the graphene layers is also discussed.

  11. Origin of Structural Transformation in Mono- and Bi-Layered Molybdenum Disulfide

    Science.gov (United States)

    Sun, Xiaoli; Wang, Zhiguo; Li, Zhijie; Fu, Y. Q.

    2016-05-01

    Mono- and multi-layered molybdenum disulfide (MoS2) is considered to be one of the next generation anode materials for rechargeable ion batteries. Structural transformation from trigonal prismatic (2H) to octahedral (1T) upon lithium or sodium intercalation has been in-situ observed experimentally using transmission electron microscope during studies of their electrochemical dynamics processes. In this work, we explored the fundamental mechanisms of this structural transformation in both mono- and bi-layered MoS2 using density functional theory. For the intercalated MoS2, the Li and Na donate their electrons to the MoS2. Based on the theoretical analysis, we confirmed that, for the first time, electron transfer is dominant in initiating this structural transformation, and the results provide an in-depth understanding of the transformation mechanism induced by the electron doping. The critical values of electron concentrations for this structural transformation are decreased with increasing the layer thickness.

  12. Secondary isotope effects in intramolecular catalysis. Mono-p-bromophenyl succinate hydrolysis

    Energy Technology Data Exchange (ETDEWEB)

    Gandour, R.D.; Stella, V.J.; Coyne, M.; Schowen, R.L.; Icaza, E.A.

    1978-04-28

    Kinetic isotope effects have been measured for the intramolecular nucleophilic carboxylate-catalyzed hydrolysis, k/sub s/, of mono-p-bromophenyl succinate and mono-p-bromophenyl succinate-d/sub 4/. The resulting isotope effect, k/sub s//sup h/sub 4///k/sub s//sup d/sub 4//, equals 1.035, a normal effect. This is contrary to what is expected for acyl transfer reactions where the transition-state structure resembles a tetrahedral intermediate. However, the direction of the isotope effect is in agreement with a transition-state structure resembling succinic anhydride. Combining this result with previous kinetic and structural studies, a detailed transition-state structure for the hydrolysis reaction is proposed. 31 references, 2 tables.

  13. Influencia de un programa de actividad física en niños y adolescentes obesos: evaluación del estrés fisiológico mediante compuestos en la saliva; protocolo de estudio

    Directory of Open Access Journals (Sweden)

    M. J. Aguilar Cordero

    2013-06-01

    Full Text Available Diferentes estudios1,2 relacionan que el estrés aumenta en los niños y adolescentes con sobrepeso y obesidad, y en consecuencia sus respuestas fisiológicas salivales (Alfa-amilasa salivar AEA, Cortisol, Citoquinas, Leptina, por eso en este estudio queremos relacionar estos dos parámetros para ver su evolución a través de un programa de Actividad Física. Si logramos reducir el sobrepeso u obesidad se debería reducir también estas respuestas fisiológicas y el estrés, por lo que mejoraría el estado de salud general de estos niños y adolescentes. El objetivo general del estudio es conocer la influencia de la actividad física, en niños y adolescentes obesos, en el estrés percibido. Se realizará un estudio observacional, descriptivo, prospectivo y longitudinal. El universo estará constituido por 60 niños y adolescentes con edades comprendidas entre 10 y 18 con sobrepeso/obesidad. La valoración tendrá lugar desde septiembre de 2012 hasta septiembre de 2013. Para la recogida de las muestras de saliva se utilizará el método ELISA³. También se recogerán variables como el IMC, hábitos de vida y alimentación. De entre los resultados esperados están el bajar el sobrepeso y obesidad en los niños mediante el programa de actividad física. Disminuir el estrés fisiológico y normalizar los parámetros salivares.

  14. Influência da distribuição da gordura corporal sobre a prevalência de hipertensão arterial e outros fatores de risco cardiovascular em indivíduos obesos

    Directory of Open Access Journals (Sweden)

    Carneiro Gláucia

    2003-01-01

    Full Text Available OBJETIVOS: Indivíduos obesos são mais predispostos à ocorrência de eventos cardiovasculares que indivíduos com peso normal. Para se avaliar o impacto da obesidade e da distribuição de gordura corporal sobre o risco cardiovascular, avaliamos uma população de indivíduos com sobrepeso ou obesidade. MÉTODOS: Foram feitas medidas do índice de massa corporal (IMC, da relação entre as medidas da cintura e do quadril (RCQ, da pressão arterial sistólica (PAS e diastólica (PAD e dos níveis da glicemia de jejum, colesterol total e triglicérides. RESULTADOS: Altas prevalências de intolerância à glicose ou diabetes (21,8%, hipercolesterolenemia (49,1%, hipertrigliceridemia (21,3% e hipertensão arterial (43,8% foram observadas nesta população. A prevalência de hipertensão aumentou de 23% no grupo com sobrepeso (IMC 25-29,9 kg/m² para 67,1% (p 40kg/m². Também a prevalência de hipertensão aumentou de 35,7% naqueles com RCQ entre 0,73 e 0,88 para 66,6% naqueles com RCQ >0,97 (p 40kg/m² (p<0,05. CONCLUSÃO: A obesidade favorece a ocorrência dos fatores de risco cardiovascular, sendo que a distribuição central da gordura corporal se destaca especialmente como fator importante no desenvolvimento da hipertensão arterial.

  15. SIMAC - A phosphoproteomic strategy for the rapid separation of mono-phosphorylated from multiply phosphorylated peptides

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Robinson, Phillip J;

    2008-01-01

    spectrometric analysis, such as immobilized metal affinity chromatography or titanium dioxide the coverage of the phosphoproteome of a given sample is limited. Here we report a simple and rapid strategy - SIMAC - for sequential separation of mono-phosphorylated peptides and multiply phosphorylated peptides from...... and an optimized titanium dioxide chromatographic method. More than double the total number of identified phosphorylation sites was obtained with SIMAC, primarily from a three-fold increase in recovery of multiply phosphorylated peptides....

  16. Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines.

    OpenAIRE

    Dubovi, E. J.; Geratz, J. D.; Shaver, S R; Tidwell, R. R.

    1981-01-01

    Several aromatic mono- and diamidines were found to block cell fusion induced by respiratory syncytial virus. The best inhibitors were able to achieve complete suppression of syncytium formation at a concentration of 1.0 microM. Inhibition occurred in respiratory syncytial virus-infected HEp-2 and CV-1 cells, but the same inhibitors were ineffective in preventing fusion induced by parainfluenza virus type 3. The fusion inhibitors did not reduce single-cycle virus yields, but did reduce multip...

  17. Dark Matter searches with Mono-X signatures at the ATLAS experiment

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00377126; The ATLAS collaboration

    2016-01-01

    At the LHC dark matter particles can be produced in association with Standard Model particles coming from initial state radiation. Searches for such processes using events with jets, photons or massive gauge bosons recoiling against large missing transverse momentum in ATLAS at 13 TeV are presented. These ``mono-X'' signatures provide powerful probes to dark matter production at the LHC, allowing for the interpretation of results in terms of simplified models with pair production of WIMPs.

  18. Systematic Behavior of the Non-dipole Magnetic Field during the 32 ka Mono Lake Excursion

    Science.gov (United States)

    Negrini, R. M.; McCuan, D.; Cassata, W. S.; Channell, J. E.; Verosub, K. L.; Liddicoat, J. C.; Knott, J. R.; Coe, R. S.; Benson, L. V.; Sarna-Wojcicki, A.; Lund, S.; Horton, R.; Lopez, J.

    2012-12-01

    Paleomagnetic excursions are enigmatic phenomena that reveal geodynamo behavior in its transitional state and provide important refinements in age control for the late Pleistocene, a critical time period for the study of paleoclimate and human evolution. We report here on two widely separated, unusually detailed records of the Mono Lake excursion (MLE) from sedimentary sequences dated at 32 ka. One of the records is from Summer Lake, Oregon. The vector components of this new record faithfully reproduce the principle features of the MLE as recorded at the type localities around Mono Lake, CA, though with greater detail and higher amplitude. Radiocarbon dates on bulk organics in the Summer Lake record confirm the 32 ka age of the MLE. The other record is from the marine Irminger Basin off of eastern Greenland and is based on the measurement of discrete samples rather than u-channels. The associated VGP paths of the two records strongly suggest systematic field behavior that includes three loci of nondipole flux whose relative dominance oscillates through time. The staggered sequence followed by the two paths through each flux locus further suggests that both the demise and return of the main field floods zonally during the excursion. The composite path is also compatible with the VGPs of a 32 ka set of lavas from New Zealand and, notably, it does not include VGPs associated with the 40 ka Laschamp excursion. This confirms that these two excursions are distinct events and, more specifically, shows that it is the 32 ka Mono Lake excursion that is recorded in the sediments surrounding Mono Lake rather than the ~40 ka Laschamp excursion.

  19. Mono-(2-Ethylhexyl) Phthalate Induces Oxidative Stress and Inhibits Growth of Mouse Ovarian Antral Follicles1

    OpenAIRE

    Wang, Wei; Craig, Zelieann R.; Basavarajappa, Mallikarjuna S.; Hafner, Katlyn S.; Flaws, Jodi A.

    2012-01-01

    Mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of the most commonly used plasticizer, di-(2-ethylhexyl) phthalate, and is considered to be a reproductive toxicant. However, little is known about the effects of MEHP on ovarian antral follicles. Thus, the present study tested the hypothesis that MEHP inhibits follicle growth via oxidative stress pathways. The data indicate that MEHP increases reactive oxygen species (ROS) levels and inhibits follicle growth in antral follicles, w...

  20. Strength and nature of hydrogen bonding interactions in mono- and di-hydrated formamide complexes.

    Science.gov (United States)

    Angelina, Emilio L; Peruchena, Nélida M

    2011-05-12

    In this work, mono- and di-hydrated complexes of the formamide were studied. The calculations were performed at the MP2/6-311++G(d,p) level of approximation. The atoms in molecules theory (AIM), based on the topological properties of the electronic density distribution, was used to characterize the different types of bonds. The analysis of the hydrogen bonds (H-bonds) in the most stable mono- and di-hydrated formamide complexes shows a mutual reinforcement of the interactions, and some of these complexes can be considered as "bifunctional hydrogen bonding hydration complexes". In addition, we analyzed how the strength and the nature of the interactions, in mono-hydrated complexes, are modified by the presence of a second water molecule in di-hydrated formamide complexes. Structural changes, cooperativity, and electron density redistributions demonstrate that the H-bonds are stronger in the di-hydrated complexes than in the corresponding mono-hydrated complexes, wherein the σ- and π-electron delocalization were found. To explain the nature of such interactions, we carried out the atoms in molecules theory in conjunction with reduced variational space self-consistent field (RVS) decomposition analysis. On the basis of the local Virial theorem, the characteristics of the local electron energy density components at the bond critical points (BCPs) (the 1/4∇ (2)ρ(b) component of electron energy density and the kinetic energy density) were analyzed. These parameters were used in conjunction with the electron density and the Laplacian of the electron density to analyze the characteristics of the interactions. The analysis of the interaction energy components for the systems considered indicates that the strengthening of the hydrogen bonds is manifested by an increased contribution of the electrostatic energy component represented by the kinetic energy density at the BCP. PMID:21506592

  1. Disturbing law of Intel 80C51 mono-computer system under UWB-EMP field

    International Nuclear Information System (INIS)

    Disturbing law of mono-computer system consisted of Intel80C51, 74LS373, 2764, DAC0832 and μA741 was introduced in UWB-EMP field. In order to find out which circuits among the system, result disturbing time as long as more than ten microseconds, in UWB-EMP field of sustained time only ten nanoseconds over. We respectively researched disturbing law of digital circuits, digital/analog transform circuits and operation amplifier circuits

  2. Strength and nature of hydrogen bonding interactions in mono- and di-hydrated formamide complexes.

    Science.gov (United States)

    Angelina, Emilio L; Peruchena, Nélida M

    2011-05-12

    In this work, mono- and di-hydrated complexes of the formamide were studied. The calculations were performed at the MP2/6-311++G(d,p) level of approximation. The atoms in molecules theory (AIM), based on the topological properties of the electronic density distribution, was used to characterize the different types of bonds. The analysis of the hydrogen bonds (H-bonds) in the most stable mono- and di-hydrated formamide complexes shows a mutual reinforcement of the interactions, and some of these complexes can be considered as "bifunctional hydrogen bonding hydration complexes". In addition, we analyzed how the strength and the nature of the interactions, in mono-hydrated complexes, are modified by the presence of a second water molecule in di-hydrated formamide complexes. Structural changes, cooperativity, and electron density redistributions demonstrate that the H-bonds are stronger in the di-hydrated complexes than in the corresponding mono-hydrated complexes, wherein the σ- and π-electron delocalization were found. To explain the nature of such interactions, we carried out the atoms in molecules theory in conjunction with reduced variational space self-consistent field (RVS) decomposition analysis. On the basis of the local Virial theorem, the characteristics of the local electron energy density components at the bond critical points (BCPs) (the 1/4∇ (2)ρ(b) component of electron energy density and the kinetic energy density) were analyzed. These parameters were used in conjunction with the electron density and the Laplacian of the electron density to analyze the characteristics of the interactions. The analysis of the interaction energy components for the systems considered indicates that the strengthening of the hydrogen bonds is manifested by an increased contribution of the electrostatic energy component represented by the kinetic energy density at the BCP.

  3. New concept research on mono-hull compounded ship form with high seakeeping performance

    Institute of Scientific and Technical Information of China (English)

    LIU Ya-dong; LI Ji-de; WANG Qing

    2003-01-01

    The seakeeping performance of a certain ship equipped with semi-submerged bow (SSB) and bow-fins is discussed. The numerical calculations are carried out on a 600t deep-V compound archetypal ship. The results show that the compounded ship form has excellent seakeeping performance and thus it establishes the theoretical foundations for the development of mono-hull compounded ship form with high seakeeping performance.

  4. Direct Electrochemical Synthesis of Mono, Bi And Polynuclear Complexes of Some Hydrazide and Hydrazone Derivatives

    OpenAIRE

    El Asmy, A. A. [احمد فوزي عبد الحميد العصمي; Amin, R. R.; Al-Ansi, T. Y.; El-Shahat, M. F.

    2000-01-01

    Transition metal complexes of mono-, di- and tetrahydrazides and their hydrazones have been prepared by electrochemical techniques using the metal as a sacrifical anode. The electrochemical oxidation of Co, Ni and Cu in non-aqueous (acetone) solution ofbenzoic hydrazide (HBzH), malonic dihydrazide HiMH), 1,1,3,3' - propanetetracarbohydrazide (I-LiPTCH), acetyl sal-isoylhydrazone (FLASH), benzolsalisolyhdrazone (H2BSH), 1,3 - malonyldisalisoylhydrazone (H4MDSH) and 1,1,3,3' -propanetetrasaliso...

  5. Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells

    OpenAIRE

    Tetz, Lauren M; David M. Aronoff; Loch-Caruso, Rita

    2015-01-01

    Background Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in polyvinyl chloride products. DEHP exposure, which is widespread in the US, increases preterm birth risk; however, the mechanisms driving this relationship are unclear. Because cyclooxygenase-2 (COX-2) dependent prostaglandin synthesis is implicated in preterm birth, we evaluated effects of mono-2-ethylhexyl phthalate (MEHP), the active metabolite of DEHP, on prostaglandin E2 (PGE2) synthesis and COX expression in huma...

  6. Anomalous Lattice Dynamics of Mono-, Bi-, and Tri-layer WTe2

    OpenAIRE

    Kim, YoungHee; Jhon, Young In; Park, June; Kim, Jae Hun; Lee, Seok; Jhon, Young Min

    2015-01-01

    Tungsten ditelluride (WTe2) is a layered material that exhibits excellent magnetoresistance and thermoelectric behaviors, which are deeply related with its distorted orthorhombic phase that may critically affect the lattice dynamics. Here, for the first time, we present comprehensive characterization of the Raman spectroscopic behavior of WTe2 from bulk to monolayer using experimental and computational methods. We discover that mono and bi-layer WTe2 can be easily identified by Raman spectros...

  7. Estudio in vivo de la oxidación mitocondrial en pacientes obesos tratados mediante restricción calórica In vivo study of mitochondrial oxidation in obese patients treated by means of calorie restriction

    Directory of Open Access Journals (Sweden)

    M.ª D. Parra

    2004-10-01

    Full Text Available La restricción calórica es la terapia nutricional más frecuente en el tratamiento de la obesidad, cuya eficacia depende de la respuesta oxidativa del organismo para evitar la modificación del peso corporal. En este contexto, el objetivo del presente trabajo fue examinarin vivo la oxidación mitocondrial de voluntarios obesos, antes y después de adelgazar, utilizando el test en aliento con 2-ceto[1-13C]isocaproato. El estudio se realizó en 32 voluntarios de ambos sexos: 16 controles (índice de masa corporal: 19,0-27,0 kg/m², y 16 obesos (índice de masa corporal: 30,0-41,6 kg/m² que siguieron un período de restricción calórica (-500 kcal durante 10 semanas. El test con 2-ceto[1-13C]isocaproato se realizó antes y después del tratamiento, a partir de la ingestión de 1 mg/kg de trazador y 20 mg/kg de L-leucina, disueltos en 200 mL de zumo de naranja. Antes y después de la ingestión (cada 10 minutos durante 2 horas, se tomaron muestras de aliento en las que se midió el enriquecimiento en13C mediante espectrometría de masas de relación isotópica. A partir de estas determinaciones se calculó el porcentaje de trazador oxidado en las mitocondrias (%13C. Los obesos tendieron a oxidar un porcentaje menor de trazador que los controles (25,1 ± 5,5% vs 27,5 ± 4,0% p = 0,175. Tras el período de intervención, la pérdida de peso medio fue -7,8 ± 3% (p The energy restriction is the most common nutritional approach to treat obesity, whose efficiency depends on oxidative response against changes in body weight. In that context, the aim of the present work was to in vivo examine the mitochondrial oxidation of obese volunteers by the 2-keto[1-13C]isocaproate breath test, before and after weight loss. Thirty-two volunteers (men and women participated: 16 controls (body mass index: 19.0-27.0 kg/m², and 16 obese (body mass index: 30.0-41.6 kg/m² who followd a caloric restriction program for 10 weeks (-500 kcal. Before and after dieting, the

  8. Biogas production from mono-digestion of maize silage-long-term process stability and requirements.

    Science.gov (United States)

    Lebuhn, M; Liu, F; Heuwinkel, H; Gronauer, A

    2008-01-01

    Biogas production from mono-digestion of maize silage was studied for more than one year in six continuously stirred, daily fed 36 L fermenters. Chemical and microbiological parameters were analysed concomitantly. The reactors acidified already after 8 months of operation at a low organic loading rate (OLR) of 2 g VS*(L*d)(-1). The TVA/TAC ratio was the most reliable parameter to indicate early process instabilities leading to acidification. A TVA/TAC threshold of 0.5 should not be exceeded. After acidification and recovery of the fermenters, propionic acid was no reliable parameter anymore to indicate process failure, since values far below the threshold of 1 g*L(-1) were obtained although the process had collapsed.The acidified reactors recovered better, showed greatly improved stability and allowed a higher OLR when a trace element (TE) cocktail was supplemented. Hydrolysis was obviously not process-limiting, results indicated that methanogens were affected. The most limiting element in long-term mono-digestion of maize silage turned out to be cobalt, but data obtained suggest that molybdenum and selenium should also be provided. TE supplementation should be designed specifically in order to meet the actual needs. TE availability for the biocenosis appears to be a key issue in biogas production, not only in mono-but also in co-digestion processes. PMID:19001720

  9. Simulation of gas hydrogen diffusion through partially water saturated mono-modal materials

    International Nuclear Information System (INIS)

    Concerning the disposal of nuclear wastes, it is important to design concrete envelopes with pore networks that allow the diffusion of hydrogen towards the outside. This work documents the relationship between geo-polymers, which are materials with a quasi mono-modal pore network, and their gaseous diffusivity capacities. Using a mono-modal material allows studying a specific pore size contribution to gaseous diffusion. The pore network is characterized by mercury porosimetry. These experimental results are used as data in a model named MOHYCAN. The modeling work consists of creating a virtual pore network. Then, water layers are deposited in this network to simulate variable water saturation levels. Finally hydrogen is transported through the virtual network using a combination of ordinary diffusion and Knudsen diffusion. MOHYCAN calculates the hydrogen diffusion coefficient for water saturation degree from 0% to 100%. The impacts of the pore network arrangement or the pore network discretization have been studied. The results are, for a quasi mono-modal material: -) the diffusion coefficient is not sensitive to different virtual pore network arrangement; -) the diffusion coefficient values have a sharp drop at specific water saturation (this is due to the water saturation of the main and unique pore family); -) a 2 pores family based model is sufficient to represent the pore network. Theses observations will not be valid if we consider a material with a large pore size distribution, like cementitious materials

  10. Arsenic speciation in Mono Lake, California: Response to seasonal stratification and anoxia

    Science.gov (United States)

    Hollibaugh, James T.; Carini, Steve; Gürleyük, Hakan; Jellison, Robert; Joye, Samantha B.; LeCleir, Gary; Meile, Christof; Vasquez, Lydia; Wallschläger, Dirk

    2005-04-01

    Mono Lake is a closed-basin, alkaline, hypersaline lake located at the western edge of the Great Basin in eastern California. We studied the distribution of arsenic (As) species in the water column of Mono Lake between February and November, 2002. This period captured the seasonal progression from winter mixing, through summer thermal stratification, to autumn overturn. Arsenic speciation was determined by ion chromatography-inductively coupled-plasma-mass spectrometry of samples preserved in the field by flash-freezing in liquid nitrogen. We found that arsenic speciation was dominated (>90%) by arsenate when oxygen was detectable. Once levels fell below 6 μmol/L O 2, arsenic speciation shifted to dominance by reduced species. Arsenate and arsenite co-occurred in a transition zone immediately below the base of the oxycline and low but significant concentrations of arsenate were occasionally detected in sulfidic hypolimnion samples. Thio-arsenic species were the dominant form of As found in sulfidic waters. Maxima of thio-arsenic species with stoichiometries consistent with mono-, di- and trithio-arsenic occurred in succession as sulfide concentration increased. A compound with a stoichiometry consistent with trithio-arsenic was the dominant As species (˜50% of total As) in high sulfide (2 mmol/L) bottom water. Lower concentrations of total As in bottom water relative to surface water suggest precipitation of As/S mineral phases in response to sulfide accumulation during prolonged anoxia.

  11. Unique Intramolecular Electronic Communications in Mono-ferrocenylpyrimidine Derivatives: Correlation between Redox Properties and Structural Nature

    International Nuclear Information System (INIS)

    Highlights: • Unique intramolecular electronic communications (electron withdrawing and π-bond delocalization effects) exist in the mono-ferrocenylpyrimidine derivatives. • The redox potential shift correlates the pyrimidine ring torsion angle with the extent of electron delocalization. • The correlation between redox properties and structural nature in mono-ferrocenylpyrimidine derivatives is evident. - Abstract: The correlation between redox properties and structural nature in a complete set of mono-ferrocenylpyrimidine derivatives (2-ferrocenylpyrimidine, 2-FcPy; 4-ferrocenylpyrimidine, 4-FcPy; 5-ferrocenylpyrimidine, 5-FcPy) was evaluated by investigating the intramolecular electronic communications. Both conventional electrochemical measurements in organic solvents and thin-film voltammetric studies of these compounds were carried out. It was discovered that their formal potentials are significantly different from each other, and shift negatively in the order of 4-FcPy > 5-FcPy > 2-FcPy. This result suggests that the intramolecular electronic communication is dictated by the delocalization effect of the π-bonding systems in 2-FcPy, and that the electron-withdrawing effect of the nitrogen atoms in the pyrimidine ring plays the key role in 4-FcPy and 5-FcPy. The single crystal X-ray structure analyis and Density Functional Theory (DFT) calculation provided additional evidence (e.g., different torsion angles between the cyclopentadienyl and pyrimidine rings) to support the observed correlation between the redox properties and structural nature

  12. p-Type Quasi-Mono Silicon Solar Cell Fabricated by Ion Implantation

    Directory of Open Access Journals (Sweden)

    Chien-Ming Lee

    2013-01-01

    Full Text Available The p-type quasi-mono wafer is a novel type of silicon material that is processed using a seed directional solidification technique. This material is a promising alternative to traditional high-cost Czochralski (CZ and float-zone (FZ material. Here, we evaluate the application of an advanced solar cell process featuring a novel method of ion implantation on p-type quasi-mono silicon wafer. The ion implantation process has simplified the normal industrial process flow by eliminating two process steps: the removal of phosphosilicate glass (PSG and the junction isolation process that is required after the conventional thermal POCl3 diffusion process. Moreover, the good passivation performance of the ion implantation process improves Voc. Our results show that, after metallization and cofiring, an average cell efficiency of 18.55% can be achieved using 156 × 156 mm p-type quasi-mono silicon wafer. Furthermore, the absolute cell efficiency obtained using this method is 0.47% higher than that for the traditional POCl3 diffusion process.

  13. Modeling of point defects and rare gas incorporation in uranium mono-carbide

    Science.gov (United States)

    Chartier, A.; Van Brutzel, L.

    2007-02-01

    An embedded atom method (EAM) potential has been established for uranium mono-carbide. This EAM potential was fitted on structural properties of metallic uranium and uranium mono-carbide. The formation energies of point defects, as well as activation energies for self migration, have been evaluated in order to cross-check the suitability of the potential. Assuming that the carbon vacancies are the main defects in uranium mono-carbide compounds, the migration paths and energies are consistent with experimental data selected by Catlow[C.R.A. Catlow, J. Nucl. Mater. 60 (1976) 151]. The insertion and migration energies for He, Kr and Xe have also been evaluated with available inter-atomic potentials [H.H. Andersen, P. Sigmund, Nucl. Instr. and Meth. B 38 (1965) 238]. Results show that the most stable defect configuration for rare gases is within uranium vacancies. The migration energy of an interstitial Xe is 0.5 eV, in agreement with the experimental value of 0.5 eV [Hj. Matzke, Science of advanced LMFBR fuels, Solid State Physics, Chemistry and Technology of Carbides, Nitrides and Carbonitrides of Uranium and Plutonium, North-Holland, 1986].

  14. Oxygen uptake of overweight and obese children at different stages of a progressive treadmill test. (Consumo de oxígeno de niños y niñas con sobrepeso y obesos en los diferentes estadios de una prueba progresiva en un tapiz rodante.

    Directory of Open Access Journals (Sweden)

    Colleen Ann Boyle

    2010-01-01

    Full Text Available AbstractIntroduction: Maximal oxygen uptake (VO2 max is associated with cardiovascular and metabolic risks but it is difficult to assess in obese children. The objective of this study was to develop an equation to estimate VO2 (mL/kg/min and to check the % of tests that were maximal according to recommended criteria. Methods: Stress tests were analyzed of 222 subjects (94 male and 128 female with a BMI above the 85 percentile for age and sex, and repeated 4 months later. Mean age was 9.4 + 1.1 years and weighed 52.4 + 13.3 kg. Body fat % (40.5 + 6.2 was determined by DXA (Hologic QDR 4500W. The protocol on the treadmill started with a warm up at 2.5 and 3 mph with a slope of 0% and 2%. The speed was kept at 3 mph for all the stages and the slope was increased 2% every 2 minutes. Statistical analysis (descriptive, t-test and ANOVAS 2x2x2 was done with SPSS 15.0. Results: Only 35% of the tests were maximal. The equation calculates was Y = 2.6x + 22.3 (x = protocol stage. Data pre and post treatment were not statistically different. Discussion: Increments in VO2 were consistent despite subject diversity (sex, % body fat, physical fitness, treatment. Conclusion: To be able to estimate VO2 at the different stages of the test without complex equipment or specialized staff, will facilitate the performance of stress tests on a daily basis.ResumenIntroducción: El consumo máximo de oxígeno (VO2 max está asociado con riesgos cardiovasculares y metabólicos pero resulta difícil valorarlo en niños y niñas obesos. El objetivo de este trabajo fue desarrollar una ecuación para estimar su VO2 (mL/kg/min y comprobar el porcentaje de pruebas máximas según los criterios recomendados. Métodos: Se analizaron las pruebas de esfuerzo de 222 sujetos (94 varones y 128 mujeres con un IMC superior al percentil 85 para su edad y sexo, y las repetidas a los 4 meses. Su edad era 9,4 + 1,1 años y pesaban 52,4 + 13,3 kg. El % de grasa corporal (40,5 + 6,2 se

  15. The synthesis of mono-6-thio-β-cyclodextrin capped CdTe QDs and its interaction with neutral red

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper presents a novel method for the synthesis of CdTe quantum dots (QDs) capped with β-cyclodextrin in aqueous solution using both TGA and mono-6-thio-β-CD as stabilizers.The interaction between mono-6-thio-β-CD-CdTe QDs and neutral red (NR) was studied with fluorescence,UV-absorption and the resonance Rayleigh scattering spectrum.When its concentration was over 7.5 × 10-6 mol/L,the neutral red began to aggregate on the surface of the mono-6-thio-β-CD-CdTe QDs,which resulted in the mono-6-thio-β-CD-CdTe QDs particle size increasing,the sharply quenched fluorescence,and the marked increase of RRS intensity.

  16. Symptoms and Immune Markers in Plasmodium/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru.

    Directory of Open Access Journals (Sweden)

    Eric S Halsey

    2016-04-01

    Full Text Available Malaria and dengue are two of the most common vector-borne diseases in the world, but co-infection is rarely described, and immunologic comparisons of co-infection with mono-infection are lacking.We collected symptom histories and blood specimens from subjects in a febrile illness surveillance study conducted in Iquitos and Puerto Maldonado, Peru, between 2002-2011. Nineteen symptoms and 18 immune markers at presentation were compared among those with co-infection with Plasmodium/dengue virus (DENV, Plasmodium mono-infection, and DENV mono-infection. Seventeen subjects were identified as having Plasmodium/DENV co-infection and were retrospectively matched with 51 DENV mono-infected and 44 Plasmodium mono-infected subjects. Those with Plasmodium mono-infection had higher levels of IL-4, IL-6, IL-10, IL-12, IL-13, IL-17A, IFN-γ, and MIP1-α/CCL3 compared with DENV mono-infection or co-infection; those with Plasmodium mono-infection had more cough than those with DENV mono-infection. Subjects with DENV mono-infection had higher levels of TGF-β1 and more myalgia than those with Plasmodium mono-infection. No symptom was more common and no immune marker level was higher in the co-infected group, which had similar findings to the DENV mono-infected subjects.Compared with mono-infection with either pathogen, Plasmodium/DENV co-infection was not associated with worse disease and resembled DENV mono-infection in both symptom frequency and immune marker level.

  17. Prevenção da síndrome metabólica em crianças obesas: uma proposta de intervenção Prevención del síndrome metabólico en niños obesos: una propuesta de intervención Prevention of metabolic syndrome in obese children: a proposal of intervention

    OpenAIRE

    Camila Buonani; Rômulo Araújo Fernandes; Loreana Sanches Silveira; Karolynne das Neves Bastos; Paula Alves Monteiro; Irineu Viotto Filho; Ismael Forte F. Júnior

    2011-01-01

    OBJETIVO: Analisar o efeito de 12 semanas de intervenção envolvendo prática de atividade física, orientações alimentar e psicológica sobre fatores de risco para o desenvolvimento da síndrome metabólica em crianças e adolescentes obesos. MÉTODOS: Estudo longitudinal com 23 crianças e adolescentes obesos, com idade entre seis e 16 anos (12,0±3,2 anos). Foram mensurados: gordura corporal total e de tronco, glicemia, colesterol total e triglicérides, pressão arterial sistólica e diastólica. Os jo...

  18. Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis.

    Science.gov (United States)

    Kumar, Kewal; Liu, Nicole; Yang, Donald; Na, Daniel; Thompson, John; Wrischnik, Lisa A; Land, Kirkwood M; Kumar, Vipan

    2015-08-15

    A library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen Trichomonas vaginalis. The structure activity studies (SAR) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of T. vaginalis at approximately 10 μM with no visual effect on mammalian cells at the same concentration.

  19. Anomalous Raman scattering and lattice dynamics in mono- and few-layer WTe2

    Science.gov (United States)

    Kim, Younghee; Jhon, Young In; Park, June; Kim, Jae Hun; Lee, Seok; Jhon, Young Min

    2016-01-01

    Tungsten ditelluride (WTe2) is a layered material that exhibits excellent magnetoresistance and thermoelectric behaviors, which are deeply related with its distorted orthorhombic phase that may critically affect the lattice dynamics of this material. Here, we report comprehensive characterization of Raman spectra of WTe2 from bulk to monolayer using experimental and computational methods. We find that mono and bi-layer WTe2 are easily identified by Raman spectroscopy since two or one Raman modes that are observed in higher-layer WTe2 are greatly suppressed below the noise level in the mono- and bi-layer WTe2, respectively. In addition, the frequency of in-plane A17 mode of WTe2 remains almost constant as the layer number decreases, while all the other Raman modes consistently blueshift, which is completely different from the vibrational behavior of hexagonal metal dichalcogenides. First-principles calculation validates experimental results and reveals that anomalous lattice vibrations in WTe2 are attributed to the formation of tungsten chains that make WTe2 structurally one-dimensional.Tungsten ditelluride (WTe2) is a layered material that exhibits excellent magnetoresistance and thermoelectric behaviors, which are deeply related with its distorted orthorhombic phase that may critically affect the lattice dynamics of this material. Here, we report comprehensive characterization of Raman spectra of WTe2 from bulk to monolayer using experimental and computational methods. We find that mono and bi-layer WTe2 are easily identified by Raman spectroscopy since two or one Raman modes that are observed in higher-layer WTe2 are greatly suppressed below the noise level in the mono- and bi-layer WTe2, respectively. In addition, the frequency of in-plane A17 mode of WTe2 remains almost constant as the layer number decreases, while all the other Raman modes consistently blueshift, which is completely different from the vibrational behavior of hexagonal metal dichalcogenides

  20. Validation of the prognostic Heidelberg re-irradiation score in an independent mono-institutional patient cohort

    International Nuclear Information System (INIS)

    Re-irradiation has been shown to be a valid option with proven efficacy for recurrent high-grade glioma patients. Overall, up to now it is unclear which patients might be optimal candidates for a second course of irradiation. A recently reported prognostic score developed by Combs et al. may guide treatment decisions and thus, our mono-institutional cohort served as validation set to test its relevance for clinical practice. The prognostic score is built upon histology, age (< 50 vs. ≥ 50 years) and the time between initial radiotherapy and re-irradiation (≤ 12 vs. > 12 months). This score was initially introduced to distinguish patients with excellent (0 points), good (1 point), moderate (2 points) and poor (3–4 points) post-recurrence survival (PRS) after re-irradiation. Median prescribed radiation dose during re-treatment of recurrent malignant glioma was 36 Gy in 2 Gy single fractions. A substantial part of the patients was additionally treated with bevacizumab (10 mg/kg intravenously at d1 and d15 during re-irradiation). 88 patients (initially 61 WHO IV, 20 WHO III, 7 WHO II) re-irradiated in a single institution were retrospectively analyzed. Median follow-up was 30 months and median PRS of the entire patient cohort 7 months. Seventy-one patients (80.7%) received bevacizumab. PRS was significantly increased in patients receiving bevacizumab (8 vs. 6 months, p = 0.027, log-rank test). KPS, age, MGMT methylation status, sex, WHO grade and the Heidelberg score showed no statistically significant influence on neither PR-PFS nor PRS. In our cohort which was mainly treated with bevacizumab the usefulness of the Heidelberg score could not be confirmed probably due to treatment heterogeneity; it can be speculated that larger multicentric data collections are needed to derive a more reliable score

  1. Efeito da atividade física associada à orientação alimentar em adolescentes obesos: comparação entre o exercício aeróbio e anaeróbio Efecto de la actividad física asociada a la orientación alimentar en adolescentes obesos: comparación entre el ejercicio aeróbico y anaeróbico Effect of physical activity associated with nutritional orientation for obese adolescents: comparison between aerobic and anaerobic exercise

    OpenAIRE

    Renata Viccari Sabia; José Ernesto dos Santos; Rosane Pilot Pessa Ribeiro

    2004-01-01

    A obesidade na adolescência é uma doença universal de prevalência mundial crescente, assumindo caráter epidemiológico como problema de saúde pública na sociedade moderna. Este trabalho teve como objetivo comparar o efeito do exercício físico aeróbio contínuo e anaeróbio intermitente associado à orientação alimentar sobre a composição corporal, as medidas bioquímicas e a capacidade física de adolescentes obesos. Foram investigados 28 adolescentes (média de idade = 13 anos), com índice de massa...

  2. Grosor de la íntima-media de la arteria carótida en adolescentes obesos y su relación con el síndrome metabólico Intima-media thickness in obese adolescents and their relation with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    C. Torrejón

    2012-02-01

    Full Text Available Introducción: Los adolescentes obesos presentan mayor riesgo cardiovascular (RCV. La medición del grosor de la intima-media (GIM arterial detecta tempranamente el compromiso vascular. Objetivo: Evaluar si los adolescentes obesos tienen mayor compromiso vascular medido por GIM que los adolescentes no obesos, y si este es mayor en aquellos con síndrome metabólico (SM. Metodología: Grupo estudio (GE, niños obesos, IMC/edad > p95, con y sin SM y grupo control, IMC/edad p10-85, sin patología nutricional ni endocrina. Se midieron concentraciones séricas de lípidos, prueba tolerancia oral a glucosa con insulinemia y ecografía de arteria carótida. Para evaluar diferencia entre grupos se utilizaron pruebas estadísticas paramétricas y no paramétricas. Resultados: Se evaluaron 45 adolescentes obesos (20 mujeres, 19 con SM, edad 13 (9-16 años y 18 controles (14 mujeres, edad 13 (11-16 años. GIM del bulbo carotideo y de la arteria carótida interna (ACI fueron significativamente mayores en GE que grupo control (0,54 vs 0,34; 0,34 vs 0,25, p Introduction: Obese adolescents have higher cardiovascular risk (CVR. Intima-media thickness (IMT detects early arterial vascular compromise. Objective: To evaluate whether obese adolescents have higher vascular compromise measured by IMT than nonobese adolescents, and if this is greater in those with metabolic syndrome (MS. Method: The study group (SG, obese children (BMI/age > p95, with and without MS and control group (CG, non-obese (BMI/age p10-85 and non nutritional or endocrine disease. We measured serum lipids, oral glucose tolerance test with insulin and carotid artery ultrasound. To evaluate the differences between test groups we used parametric and nonparametric statistics. Results: We evaluated 45 obese adolescents (20 women, 19 with MS, age 13 (9-16 years and 18 controls (14 women, aged 13 (11-16 years. IMT of carotid bulb and internal carotid artery (ICA were significantly higher in SG than CG

  3. Systemic cytokine and interferon responsiveness Patterns in HIV and HCV mono and co-infections.

    Science.gov (United States)

    Fernandez-Botran, Rafael; Joshi-Barve, Swati; Ghare, Smita; Barve, Shirish; Young, Mary; Plankey, Michael; Bordon, Jose

    2014-11-01

    The role of host response-related factors in the fast progression of liver disease in individuals co-infected with HIV and HCV viruses remains poorly understood. This study compared patterns of cytokines, caspase-1 activation, endotoxin exposure in plasma as well as interferon signaling in peripheral blood mononuclear cells from HIV/HCV co-infected (HIV(+)/HCV(+)), HCV mono-infected (HIV(-)/HCV(+)), HIV mono-infected (HIV(+)/HCV(-)) female patients and HIV- and HCV-uninfected women (HIV(-)/HCV(-)) who had enrolled in the Women's Interagency HIV Study (WIHS). HIV(+)/HCV(+) women had higher plasma levels of pro-inflammatory cytokines as well as caspase-1 compared with other groups. Both HIV(+)/HCV(+) and HIV(+)/HCV(-) women had significantly higher sCD14 levels compared with other groups. Peripheral blood mononuclear cells from HCV mono-infected patients had reduced levels of phosphorylation of STAT1 compared with other groups as well as lower basal levels of expression of the IFN-stimulated genes, OAS1, ISG15, and USP18 (UBP43). Basal expression of USP18, a functional antagonist of ISG15, as well as USP18/ISG15 ratios were increased in the HIV(+)/HCV(+) group compared with HIV(-)/HCV(+) and HIV(+)/HCV(-) groups. A more pronounced systemic inflammatory profile as well as increased expression ratios of USP18 to ISG15 may contribute to the more rapid progression of liver disease in HIV(+)/HCV(+) individuals. PMID:24955730

  4. Seed mediated synthesis of highly mono-dispersed gold nanoparticles in the presence of hydroquinone

    Science.gov (United States)

    Kumar, Dhiraj; Mutreja, Isha; Sykes, Peter

    2016-09-01

    Gold nanoparticles (AuNPs) are being studied for several biomedical applications, including drug delivery, biomedical imaging, contrast agents and tumor targeting. The synthesis of nanoparticles with a narrow size distribution is critical for these applications. We report the synthesis of highly mono-dispersed AuNPs by a seed mediated approach, in the presence of tri-sodium citrate and hydroquinone (HQ). AuNPs with an average size of 18 nm were used for the synthesis of highly mono-dispersed nanocrystals of an average size 40 nm, 60 nm, 80 nm and ∼100 nm; but the protocol is not limited to these sizes. The colloidal gold was subjected to UV–vis absorbance spectroscopy, showing a red shift in lambda max wavelength, peaks at 518.47 nm, 526.37 nm, 535.73 nm, 546.03 nm and 556.50 nm for AuNPs seed (18 nm), 40 nm, 60 nm, 80 nm and ∼100 nm respectively. The analysis was consistent with dynamic light scattering and electron microscopy. Hydrodynamic diameters measured were 17.6 nm, 40.8 nm, 59.8 nm, 74.1 nm, and 91.4 nm (size by dynamic light scattering—volume %); with an average poly dispersity index value of 0.088, suggesting mono-dispersity in the size distribution, which was also confirmed by transmission electron microscopy analysis. The advantage of a seed mediated approach is a multi-step growth of nanoparticle size that enables us to control the number of nanoparticles in the suspension, for size ranging from 24.5 nm to 95.8 nm. In addition, the HQ-based synthesis of colloidal nanocrystals allowed control of the particle size and size distribution by tailoring either the number of seeds, amount of gold precursor or reducing agent (HQ) in the final reaction mixture.

  5. Escitalopram tolerability as mono- versus augmentative therapy in patients with affective disorders: a naturalistic study

    Directory of Open Access Journals (Sweden)

    Dell'Osso B

    2013-02-01

    Full Text Available Bernardo Dell’Osso, Chiara Arici, Cristina Dobrea, Giulia Camuri, Beatrice Benatti, A Carlo AltamuraUniversity of Milan, Department of Psychiatry, Fondazione IRCSS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, ItalyBackground: Escitalopram is a selective serotonin reuptake inhibitor, widely used in the treatment of affective disorders. The purpose of this study was to examine its safety and tolerability, as mono- versus augmentative therapy, in a group of patients with affective disorders.Materials and methods: The sample consisted of 131 patients suffering from different affective disorders, including major depressive disorder, bipolar disorder, and generalized anxiety disorder, who received escitalopram for at least 4 weeks. Data were analyzed on the basis of mono- versus augmentative therapy, as well as age, gender, mean daily dosage, and patterns of combination therapy.Results: Sixty-seven (51.1% patients were treated with monotherapy (mean dose of 11.76 mg/day and 64 (48.9% with augmentative escitalopram (mean dose of 12.81 mg/day. The mean duration of escitalopram treatment was 14 months. The most frequently combined compounds were: other antidepressants (36.5%, mood stabilizers (33.4%, and atypical antipsychotics (30.1%. Side effects were reported in 5.3% of the total sample and the most common were insomnia (2.3%, nausea (2.3%, and dizziness (0.8%. No significant difference, in terms of tolerability, in mono- versus augmentative therapy groups was found. In addition, neither age nor gender was significantly correlated with a greater presence of side effects. Finally, no significant correlation between dosage and side effects was observed.Conclusion: Over a 14-month observation period, escitalopram, either as monotherapy or an augmentative treatment, was found to be well tolerated in a large sample of patients with affective disorders, with an overall low rate of side effects.Keywords: affective disorders, escitalopram

  6. Seed mediated synthesis of highly mono-dispersed gold nanoparticles in the presence of hydroquinone

    Science.gov (United States)

    Kumar, Dhiraj; Mutreja, Isha; Sykes, Peter

    2016-09-01

    Gold nanoparticles (AuNPs) are being studied for several biomedical applications, including drug delivery, biomedical imaging, contrast agents and tumor targeting. The synthesis of nanoparticles with a narrow size distribution is critical for these applications. We report the synthesis of highly mono-dispersed AuNPs by a seed mediated approach, in the presence of tri-sodium citrate and hydroquinone (HQ). AuNPs with an average size of 18 nm were used for the synthesis of highly mono-dispersed nanocrystals of an average size 40 nm, 60 nm, 80 nm and ˜100 nm; but the protocol is not limited to these sizes. The colloidal gold was subjected to UV-vis absorbance spectroscopy, showing a red shift in lambda max wavelength, peaks at 518.47 nm, 526.37 nm, 535.73 nm, 546.03 nm and 556.50 nm for AuNPs seed (18 nm), 40 nm, 60 nm, 80 nm and ˜100 nm respectively. The analysis was consistent with dynamic light scattering and electron microscopy. Hydrodynamic diameters measured were 17.6 nm, 40.8 nm, 59.8 nm, 74.1 nm, and 91.4 nm (size by dynamic light scattering—volume %); with an average poly dispersity index value of 0.088, suggesting mono-dispersity in the size distribution, which was also confirmed by transmission electron microscopy analysis. The advantage of a seed mediated approach is a multi-step growth of nanoparticle size that enables us to control the number of nanoparticles in the suspension, for size ranging from 24.5 nm to 95.8 nm. In addition, the HQ-based synthesis of colloidal nanocrystals allowed control of the particle size and size distribution by tailoring either the number of seeds, amount of gold precursor or reducing agent (HQ) in the final reaction mixture.

  7. Alterações dos parâmetros clínicos e laboratoriais em pacientes obesos com diabetes melito tipo 2 submetidos à derivação gastrojejunal em y de Roux sem anel

    Directory of Open Access Journals (Sweden)

    Michelle Varaschim

    2012-06-01

    Full Text Available OBJETIVOS: Verificar as alterações do peso e índice de massa corporal em pacientes obesos grau II e III com diabete melito tipo 2 nos períodos pré e pós-operatório e as alterações dos parâmetros laboratoriais de glicemia de jejum, glicemia pós-prandial, hemoglobina glicada, insulina nos períodos pré e pós-operatório. MÉTODOS: Realizou-se estudo prospectivo selecionando 40 pacientes com obesidade grau II e III, submetidos à derivação gastrojejunal em Y-de-Roux sem anel. Analisou-se no pré e pós-operatório de 60 dias o peso, índice de massa corporal, glicemia de jejum, glicemia pós-prandial, hemoglobina glicada e insulina. RESULTADOS: O peso médio pré-operatório foi de 107,3Kg diminuindo para 89,5Kg no pós-operatório. O índice de massa corporal médio inicial foi de 39,5Kg/m2 e 32,9Kg/m2 com 60 dias de pós-operatório. A glicemia de jejum no pré-operatório foi de 132 mg/dl e no pós-operatório diminuiu 40,4 mg/dl em média. A glicemia pós-prandial foi de 172 mg/dl no pré-operatório e 111,6 mg/dl no controle pós-operatório. A hemoglobina glicada inicial foi de 7% declinando para 5,7% no pós-operatório. A insulina pré-operatória foi 29,6 uIU/ml e a pós-operatória 13,9 uIU/ml. Todas as variáveis apresentaram significância estatística com p<0,001. CONCLUSÃO: Houve significante diminuição de peso e no índice de massa corporal entre os períodos pré e pós-operatórios e diminuição também significante dos parâmetros laboratoriais de glicemia de jejum, glicemia pós-prandial, hemoglobina glicada, insulina entre os mesmos períodos.

  8. Rabdomiólise em paciente obeso mórbido submetido a gastroplastia redutora e durante revascularização de membro superior em paciente pediátrico: relato de casos

    Directory of Open Access Journals (Sweden)

    Abrão Maria Angélica

    2006-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A rabdomiólise é uma síndrome que decorre da lesão ao músculo esquelético. Sua etiologia é ampla, trazendo um interesse particular, quando se manifesta como complicação intra ou pós-anestésica. O objetivo desse relato foi mostrar dois casos de rabdomiólise ocorridos no pós-operatório de intervenções cirúrgicas de longa duração, em pacientes com obesidade mórbida e lesão traumática, enfatizando a sua relação com a anestesia. RELATO DOS CASOS: O primeiro caso é de um paciente com 39 anos, obeso mórbido, IMC 62, submetido a gastroplastia redutora por laparotomia, sob anestesia geral. Apresentou, no pós-operatório, fraqueza muscular nos membros superiores e inferiores e alterações da sensibilidade. Evoluiu com dor muscular e urina avermelhada. O aumento dos níveis plasmáticos da enzima creatinocinase (CK confirmou o diagnóstico de rabdomiólise. Tratado com hidratação forçada e diurético, não evoluiu com insuficiência renal, porém teve alta com seqüela muscular e neurológica. O segundo caso apresenta uma criança de sete anos, vítima de acidente com porta de vidro, operada de urgência para revascularização do membro superior esquerdo. Apresentou mudança da coloração da urina, que se tornou avermelhada, durante a anestesia. Foram administrados bicarbonato de sódio e manitol por via venosa, com os objetivos de alcalinizar a urina e aumentar o débito urinário. Enviado ao CTI, onde foi confirmada a hipótese de rabdomiólise, pelo aumento da enzima CK e pela mioglobinúria. Obteve alta no 10º dia de internação, sem seqüelas. CONCLUSÕES: Os casos apresentados mostraram os fatores de risco da rabdomiólise e sua relação com a anestesia e a cirurgia. O diagnóstico precoce é importante, no sentido de um tratamento rápido e agressivo, a fim de se evitarem complicações mais graves.

  9. Transient heating and evaporation of moving mono-component liquid fuel droplets

    DEFF Research Database (Denmark)

    Yin, Chungen

    2016-01-01

    This paper presents a complete description of a model for transient heating and evaporation of moving mono-component liquid fuel droplets. The model mainly consists of gas phase heat and mass transfer analysis, liquid phase analysis, and droplet dynamics analysis, which address the interaction...... or modelling results of heating and evaporation of n-Heptane and n-Decane droplets in literature), so that the model can be readily and reliably extended to more generic applications (e.g., heating and evaporation of multi-component liquid fuel droplets, thermochemical conversion of commercially available...

  10. Upgrading of the Mono Media Filters in Water Treatment Plants by Changing Filter Media

    OpenAIRE

    L Rezaei; V Alipour

    2011-01-01

    "n "n "nBackground and Objectives:Dual media filters have two different layer beds consist of sand and Anthracite. Advantage of dual media filters is longer run duration and more filtration rate. The purpose of this study was to achieve a performable model to improve single media Filters in water treatment plants."nMaterials and Methods: in this cross-sectional study, two pilots; mono and dual media were made and in a 5 month period samples taking were done. Total samples taken from input and...

  11. Polyelectrolyte Properties in Mono and Multi-Valent Ionic Media: Brushes and Complex Coacervates

    Science.gov (United States)

    Farina, Robert M.

    Materials composed of polyelectrolytes have unique and interesting physical properties resulting primarily from their charged monomer segments. Polyelectrolytes, which exist in many different biological and industrial forms, have also been shown to be highly responsive to external environmental changes. Here, two specific polyelectrolyte systems, brushes and complex coacervates, are discussed in regards to how their properties can be tailored by adjusting the surrounding ionic environment with mono and multi-valent ions. End-tethered polyelectrolyte brushes, which constitute an interesting and substantial portion of polyelectrolyte applications, are well known for their ability to provide excellent lubrication and low friction when coated onto surfaces (e.g. articular cartilage and medical devices), as well as for their ability to stabilize colloidal particles in solution (e.g. paint and cosmetic materials). These properties have been extensively studied with brushes in pure mono-valent ionic media. However, polyelectrolyte brush interactions with multi-valent ions in solution are much less understood, although highly relevant considering mono and multi-valent counterions are present in most applications. Even at very low concentrations of multi-valent ions in solution, dramatic polyelectrolyte brush physical property changes can occur, resulting in collapsed chains which also adhere to one another via multi-valent bridging. Here, the strong polyelectrolyte poly(sodium styrene sulfonate) was studied using the Surface Forces Apparatus (SFA) and electrochemistry in order to investigate brush height and intermolecular interactions between two brushes as a function of multi-valent counterion population inside a brush. Complex coacervates are formed when polyanions and polycations are mixed together in proper conditions of an aqueous solution. This mixing results in a phase separation of a polymer-rich, coacervate phase composed of a chain network held together via

  12. Asociaciones palinológicas en las formaciones Los Monos (Devónico) e Itacua (Carbonífero Inferior) en Balapuca (Cuenca Tarija), sur de Bolivia: Parte 1. Formación Los Monos Palynological assemblages present in Los Monos (Devonian) and Itacua (Lower Carboniferous) formations at Balapuca (Tarija basin), southern Bolivia: Part One. Los Monos Formation

    OpenAIRE

    Mercedes di Pasquo

    2007-01-01

    Se caracterizan cuali-cuantitativamente dos asociaciones palinológicas recuperadas de ocho muestras fértiles de la Formación Los Monos (Eifeliano tardío-Frasniano temprano), expuesta en la localidad de Balapuca, ubicada en la margen boliviana del río Bermejo en la sierra de San Telmo. Esta unidad depositada en la Cuenca Tarija, sobreyace a la Formación Pescado (o Huamampampa, Emsiano-Eifeliano), y subyace, cuando está preservada, a la Formación Iquirí (Frasniano-Famenniano). La sección litoló...

  13. High-resolution seismic imaging, Mono Lake fault zone, eastern Sierra region, Walker Lane, California

    Science.gov (United States)

    Jayko, A. S.; Childs, J. R.; Hart, P. E.; Bursik, M. I.; McClain, J. S.

    2012-12-01

    Multiple strands of the Mono Lake fault zone (MLfz), a segment of the Sierra Nevada frontal fault zone, have been imaged on several high-resolution seismic reflection profiles collected during 2009 and 2011 at Mono Lake. The profiles show coherent reflectors to about 30-40 ms depth below the lake bottom (~30 m thick section) in nearshore areas north of the Lee Vining delta. The MLfz is well imaged on 8 lines including 4 lines ~normal to the trend of the fault zone. The fault zone is ~ 0.75 km wide. Deep reflection horizons appear gently tilted and rotated into the fault zone with a prominent clastic wedge overlying the west-tilted horizons. Shallow reflectors above the clastic wedge are generally east-sloping, but noticeably less inclined above the fault zone. At least two ruptures offset Holocene deposits, with ~0.5-1.8 m dip-slip offset around 2.5 ka and ~3.6-6.13 m dip-slip offset around 4.7 to 6.25 ka. The ages of reflection horizons are estimated using published Holocene and late Pleistocene sedimentation rates, as well as correlation with a published nearby shallow core. The short term fault slip rate based on the timing of the most recent event and multiple events in the profile lines suggests fault slip rates of about 0.26 to 0.55 m/ka using ages based only on sedimentation rate and of about 0.31 to 0.34 m/ka using correlation ages from nearby shallow core. This offshore dip-slip rate is significantly lower than previous published 1.0-2.0 m/ka dip-slip rates estimated using cosmogenic dating of Tioga glacial moraines in Lundy Canyon and offset older moraines. The offset on the large scarp in Lundy Canyon (~20 m) decreases both north and south of the canyon and flanking lateral moraines where the scarp is on the order of only ~4-7 m high. A possible explanation for the apparent difference in MLfz slip rates onshore and offshore in this part of Mono Basin may be soft sediment deformation of saturated glacial-deltaic sediment within Lundy Canyon that causes

  14. Efeito da mono-semi-carbazona do adrenocromo sobre o metabolismo de frangos de corte

    OpenAIRE

    Andriguetto, Jose Luciano

    2012-01-01

    Este estudo foi planejado com o objetivo de verificar o efeito da mono-semi-carbazona do adrenocromo (MSCA), um derivado estável do adrenocromo, sobre o metabolismo de frangos de corte, machos e fêmeas. A MSCA foi pouco pesquisada em termos de sua atividade sobre o organismo animal, inexistindo estudos da ação de substância em frangos de corte. Os efeitos da MSCA sobre o metabolismo de frangos de corte foram avaliados através da performance produtiva das aves e por acompanhamento da atividade...

  15. Effects of spin-orbit interaction on the electronic structure of mono-layer quantum wires

    Science.gov (United States)

    Vaseghi, B.; Ghaffari, A.

    2016-07-01

    Simultaneous effects of spin-orbit interaction, external electric and magnetic fields and dimension on the electronic structure of a mono-layer quantum wire are investigated in this paper. Due to the direct effects of external electric field on the structure's symmetries and spin-orbit interaction, energy eigenvalues and functions of the system are calculated with axial or in-plane electric field. It is shown that spin-orbit interaction modifies energy eigenvalues and functions of the system with regard to external factors.

  16. Effects of methotrexate on rat P-450 cytochrome mono-oxygenases

    International Nuclear Information System (INIS)

    Methotrexate, an anti-cancerous agent, acts as an anti-metabolite of the nucleic acids which synthesis is then inhibited. Using aminopyrine breath test after methotrexate processing, the effects of the molecule on activities of the hepatocyte P-450 cytochrome mono-oxygenases, are studied. Breath micro-tests with carbon 13-labelled aminopyrine have been carried out to observe the metabolism evolution. Micro-test results have been compared to microsomal enzymatic activities for various substrates, and also to P-450 cytochrome ratio. Results show that methotrexate induces a reduction in the P-450 cytochrome ratio, and thus reduce the hepatic biotransformation process. 1 fig., 30 refs

  17. Mixtures of mono-, di- and tri-glycerides as energy supplements to broilers’ diets

    OpenAIRE

    Sara Minieri; Clara Sargentini; Francesco Petacchi,; Mauro Antongiovanni; Arianna Buccioni

    2010-01-01

    Mixtures of mono-, di- and tri-glycerides from olive oil (MDT) were added to: palm oil (PO), olive oil (OO), soybean oil (SO), free fatty acids from palm oil (PFA), free fatty acids from olive oil (OFA). The compound mixtures were used as energy supplements in the diets of broiler chickens in comparison with plain SO and plain animal fat (AF). Two hundred and ten birds were randomly allotted to 7 dietary treatments with the diverse oil sources: 6 birds per cage, 5 cages per treatment. The eff...

  18. Search for Dark Matter in Mono-Photon Events at 13 TeV with ATLAS

    CERN Document Server

    Ratti, Maria Giulia; The ATLAS collaboration

    2016-01-01

    A search for Dark Matter in events with an energetic photon and large missing transverse momentum with the ATLAS experiment is presented. The analysis is performed on the data collected from proton-proton collisions delivered by the LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 3.2 fb−1. A solid estimation of the amount of mono-photon events that are due to Standard Model processes is the key ingredient for this search. The techniques developed at this aim are presented. Results are interpreted in terms of direct production of Dark Matter particles.

  19. Control and estimation algorithms for the stabilization of VTOL UAVS from mono-camera measurements.

    OpenAIRE

    De Plinval, H.; Eudes, A.; Morin, P.

    2014-01-01

    This paper concerns the control of Vertical Take-Off and Landing (VTOL) Unmanned Aerial Vehicles (UAVs) based on exteroceptive measurements obtained from a mono-camera vision system. By assuming the existence of a locally planar structure in the field of view of the UAV’s videocamera, the so-called homography matrix can be used to represent the vehicle’s motion between two views of the structure. In this paper we report recent results on both the problem of homography estimation from the fusi...

  20. Simulation study of accelerator based quasi-mono-energetic epithermal neutron beams for BNCT.

    Science.gov (United States)

    Adib, M; Habib, N; Bashter, I I; El-Mesiry, M S; Mansy, M S

    2016-01-01

    Filtered neutron techniques were applied to produce quasi-mono-energetic neutron beams in the energy range of 1.5-7.5 keV at the accelerator port using the generated neutron spectrum from a Li (p, n) Be reaction. A simulation study was performed to characterize the filter components and transmitted beam lines. The feature of the filtered beams is detailed in terms of optimal thickness of the primary and additive components. A computer code named "QMNB-AS" was developed to carry out the required calculations. The filtered neutron beams had high purity and intensity with low contamination from the accompanying thermal, fast neutrons and γ-rays.

  1. Thorium Mono- and Bis(imido) Complexes Made by Reprotonation of cyclo-Metalated Amides

    OpenAIRE

    Bell, Nicola L.; Maron, Laurent; Arnold, Polly L

    2015-01-01

    Molecules containing actinide–nitrogen multiple bonds are of current interest as simple models for new actinide nitride nuclear fuels, and for their potential for the catalytic activation of inert hydrocarbon C–H bonds. Complexes with up to three uranium–nitrogen double bonds are now being widely studied, yet those with one thorium–nitrogen double bond are rare, and those with two are unknown. A new, simple mono(imido) thorium complex and the first bis(imido) thorium complex, K[Th(═NAr)N″3] a...

  2. Doença hepática gordurosa não alcoólica em escolares obesos Nonalcoholic fatty liver disease in obese children

    Directory of Open Access Journals (Sweden)

    Fabíola Isabel S. Souza

    2008-06-01

    Full Text Available OBJETIVO: Avaliar a prevalência de alterações hepáticas ao ultra-som e de elevação da alanina aminotransferase (ALT em crianças com sobrepeso e obesidade, além de relacionar a presença de alterações com peroxidação lipídica, perfil lipídico e resistência insulínica. MÉTODOS: Estudo transversal, prospectivo e controlado de 67 crianças com sobrepeso/obesidade (38 do sexo feminino e média de idade de 8,6 anos, pareadas por sexo e idade com 65 eutróficas. A avaliação bioquímica consistiu de perfil lipídico (LDL-c, HDL-c e triglicerídeos; ALT; substâncias reativas ao ácido tiobarbitúrico (TBARS; glicemia e insulina, utilizadas para o cálculo do Homeostasis Model Assessment Insulin Resistance (HOMA-IR. A esteatose hepática, avaliada por ultra-sonografia por um único examinador, foi classificada em difusa leve, moderada e grave. RESULTADOS: Elevação de ALT (>40U/L foi encontrada em 3% e alterações ultra-sonográficas do fígado em 57,4% das crianças com sobrepeso e obesidade. O Grupo Sobrepeso/Obesidade apresentou maior percentual de ALT >18U/L (OR 4,2; p=0,0006 e de hipertrigliceridemia (OR 4,2; p18U/L. CONCLUSÕES: A freqüência de ALT >40U/L foi baixa e a de esteatose foi alta. As alterações ultra-sonográficas hepáticas não mostraram associação com o estado nutricional nem com os níveis de ALT. Por sua vez, triglicerídeos aumentados associaram-se com níveis mais elevados de ALT.OBJECTIVE: To evaluate the prevalence of altered hepatic ultrasound and elevated serum alanine aminotransferase (ALT in overweight and obese children, as well as to relate them to lipid peroxidation, lipid profile and insulin resistance. METHODS: A prospective, controlled, cross-sectional study was performed with 67 overweight and obese children (38 female, mean age of 8,6 years paired by gender and age with 65 eutrophic controls. The following parameters were evaluated: lipid profile (LDL-c, HDL-c, triglycerides, ALT, lipid

  3. [Study on biodegradation of 2,4-DCP by anaerobic sludge acclimated by mixed mono-chlorphenols].

    Science.gov (United States)

    Zhang, Wen; Chen, Ling; Ji, Jun-Ping; Xia, Si-Qing

    2007-06-01

    Purpose of this study was to determine the treatability of 2,4-dichlorophenol (2,4-DCP) by anaerobic granular sludge which was acclimated by mixed mono-chlorphenols (2-CP, 4-MCP). The characteristic of degradation of 2,4-DCP by anaerobic sludge acclimated by mixed mono-chlorphenols was investigated through shake flask study and performance of continuous flow anaerobic bioreactors. The difference of degradation of 2,4-DCP by acclimated and unacclimated sludge was also compared. 2,4-DCP was degraded at 50 h and 180 h respectively for acclimated and unacclimated sludge, which testified that acclimated sludge could more effectively degrade 2,4-DCP. Although the intermediate product 4-MCP was present in both reaction system, 4-MCP could be degraded completely after 400 h in the acclimated sludge but accumulated in the unacclimated sludge. Therefore, acclimation by the mixed mono-chlorphenols (2-CP, 4-MCP) could enhance the ability of para- and meta-dechlorination for anaerobic sludge and increase the treatability of 2,4-DCP. The results of continuous anaerobic sludge-suspended carrier bioreactor (ASSCB) indicate that inoculation of the acclimated sludge by mixed mono-chlorphenols can degrade two mono-chlorphenols simultaneously, shorten the setup period, and increase the efficiency of degrading 2,4-DCP. 2-CP was easily degraded with removal rate of over 80% . While the removal rate of 4-MCP was fluctuating within 30% - 80% with changes of its influent concentration. PMID:17674731

  4. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    Directory of Open Access Journals (Sweden)

    Dongjuan Yuan

    2014-06-01

    Full Text Available Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1 from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1, Penicillium camembertii lipase U-150 (PCL, and Aspergillus oryzae lipase (AOL. Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  5. Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.

    Science.gov (United States)

    Yuan, Dongjuan; Lan, Dongming; Xin, Ruipu; Yang, Bo; Wang, Yonghua

    2014-01-01

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1), Penicillium camembertii lipase U-150 (PCL), and Aspergillus oryzae lipase (AOL). Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity. PMID:24927145

  6. [Study on biodegradation of 2,4-DCP by anaerobic sludge acclimated by mixed mono-chlorphenols].

    Science.gov (United States)

    Zhang, Wen; Chen, Ling; Ji, Jun-Ping; Xia, Si-Qing

    2007-06-01

    Purpose of this study was to determine the treatability of 2,4-dichlorophenol (2,4-DCP) by anaerobic granular sludge which was acclimated by mixed mono-chlorphenols (2-CP, 4-MCP). The characteristic of degradation of 2,4-DCP by anaerobic sludge acclimated by mixed mono-chlorphenols was investigated through shake flask study and performance of continuous flow anaerobic bioreactors. The difference of degradation of 2,4-DCP by acclimated and unacclimated sludge was also compared. 2,4-DCP was degraded at 50 h and 180 h respectively for acclimated and unacclimated sludge, which testified that acclimated sludge could more effectively degrade 2,4-DCP. Although the intermediate product 4-MCP was present in both reaction system, 4-MCP could be degraded completely after 400 h in the acclimated sludge but accumulated in the unacclimated sludge. Therefore, acclimation by the mixed mono-chlorphenols (2-CP, 4-MCP) could enhance the ability of para- and meta-dechlorination for anaerobic sludge and increase the treatability of 2,4-DCP. The results of continuous anaerobic sludge-suspended carrier bioreactor (ASSCB) indicate that inoculation of the acclimated sludge by mixed mono-chlorphenols can degrade two mono-chlorphenols simultaneously, shorten the setup period, and increase the efficiency of degrading 2,4-DCP. 2-CP was easily degraded with removal rate of over 80% . While the removal rate of 4-MCP was fluctuating within 30% - 80% with changes of its influent concentration.

  7. Efeito da sibutramina na redução do peso e no perfil metabólico em indivíduos obesos de uma população brasileira

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Menezes

    2010-12-01

    Full Text Available O objetivo deste trabalho é avaliar a eficácia e a segurança da dose de 20 mg/dia de sibutramina em voluntários obesos, com IMC superior a 35, e compará-las com a dose de 10 mg/dia e à mudança de estilo de vida de pacientes com IMC inferior a 35 (a avaliação e a comparação foram realizadas em um período de 24 semanas. Foram submetidos a um estudo transversal 54 voluntários, distribuídos em três grupos de observação: grupo sem tratamento farmacológico (GMEV, grupo com IMC inferior a 35 e uma dose de 10 mg/ dia de sibutramina (G1 e grupo com IMC superior a 35 e dose de 20 mg/ dia de sibutramina (G2. Os parâmetros avaliados foram peso, circunferência abdominal e perfil metabólico. Os grupos submetidos ao tratamento farmacológico demonstraram maior redução do peso (G1: redução média de 9,4% ; G2: redução média de 20,6% quando comparados a indivíduos sem tratamento farmacológico (GMEV: redução de 3,9%, assim como da circunferência abdominal (redução de 7,1%, 12,8% e 3,1% em G1, G2 e GMEV, respectivamente. Em relação aos achados laboratoriais, foram observados redução da glicemia de jejum (14,8%, 22,9% e 5% em G1, G2 e GMEV, respectivamente, aumento do HDL colesterol (31,2%, 40% e 14,2% em G1, G2 e GMEV, respectivamente e redução do colesterol total (29,0%, 32,8% e 13,7% em G1, G2 e GMEV, respectivamente. Os resultados deste estudo demonstram que a dose de 20 mg de sibutramina é uma indicação segura e eficaz em pacientes obesos com IMC superior a 35. Palavras-chave: Sibutramina. Obesidade. Circunferência Abdominal. Dislipidemia. Diabetes Mellitus, Tipo 2. Ciclobutanos. ABSTRACT Effects of sibutramine on weight reduction and metabolic profile in obese individuals in a brazilian population The aim of this study is to assess the efficacy and safety of an oral daily dose of 20 mg sibutramine in obese volunteers (BMI > 35, in comparison with a dose of 10 mg/day and changed lifestyle in patients whose BMI is

  8. Ash production and dispersal from sustained low-intensity Mono-Inyo eruptions

    Science.gov (United States)

    Black, Benjamin A.; Manga, Michael; Andrews, Benjamin

    2016-08-01

    Recent rhyolitic volcanism has demonstrated that prolonged low-intensity ash venting may accompany effusive dome formation. We examine the possibility and some consequences of episodes of extended, weak ash venting at the rhyolitic Mono-Inyo chain in Eastern California. We describe ash-filled cracks within one of the youngest domes, Panum Crater, which provide a textural record of ash venting during dome effusion. We use synchrotron-based X-ray computed tomography to characterize the particles in these tuffisites. Particle sizes in well-sorted tuffisite layers agree well with grain size distributions observed during weak ash venting at Soufrière Hills Volcano, Montserrat, and yield approximate upper and lower bounds on gas velocity and mass flux during the formation of those layers. We simulate ash dispersal with Ash3d to assess the consequences of long-lived Mono-Inyo ash venting for ash deposition and the accompanying volcanic hazards. Our results highlight the sensitivity of large-scale outcomes of volcanic eruptions to small-scale processes.

  9. Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

    Directory of Open Access Journals (Sweden)

    Wen Zhu

    2013-12-01

    Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

  10. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    KAUST Repository

    Ghoneim, Mohamed T.

    2015-12-11

    In today’s digital world, complementary metal oxide semiconductor (CMOS) technology enabled scaling of bulk mono-crystalline silicon (100) based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm) mono-crystalline (100) silicon (detached from bulk substrate) by utilizing deterministic pattern of porous network of vertical “through silicon” micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs) with high-κ/metal gate stacks.

  11. Evaluation of mono or mixed cultures of lactic acid bacteria in type II sourdough system.

    Science.gov (United States)

    Ekinci, Raci; Şimşek, Ömer; Küçükçuban, Ayca; Nas, Sebahattin

    2016-01-01

    The aim of this study was to evaluate the use of mono and mixed lactic acid bacteria (LAB) cultures to determine suitable LAB combinations for a type II sourdough system. In this context, previously isolated sourdough LAB strains with antimicrobial activity, which included Lactobacillus plantarum PFC22, Lactobacillus brevis PFC31, Pediococcus acidilactici PFC38, and Lactobacillus sanfranciscensis PFC80, were used as mono or mixed culture combinations in a fermentation system to produce type II sourdough, and subsequently in bread dough production. Compared to the monoculture fermentation of dough, the use of mixed cultures shortened the adaptation period by half. In addition, the use of mixed cultures ensured higher microbial viability, and enhanced the fruity flavor during bread dough production. It was determined that the combination of L. plantarum PFC22 + P. acidilactici PFC38 + L. sanfranciscensis PFC80 is a promising culture mixture that can be used in the production of type II sourdough systems, and that may also contribute to an increase in metabolic activity during bread production process.

  12. TRUST IN MONO-ETHNIC AND MIXED-ETHNIC ASSOCIATIONS IN PENANG

    Directory of Open Access Journals (Sweden)

    James K. Campbell

    2007-01-01

    Full Text Available Investigation into trust has become a topical issue in current socialscience research. This is, in large part, a result of a perception that trust in institutions has declined markedly in the past two decades. This paper investigates trust in some of Penang’s civil associations as a way of measuring the health of social capital in Penang. It focuses on issues of trust and diversity since both are critical issues in Malaysian society in general and civil associations in particular. We began our analysis expecting higher forms of trust among members in the mono-ethnic associations, based on the power of bonding. However, findings from this study tend to suggest that rather than leading to lesser trust and infectiveness, involvement in mixed-ethnic associations have in fact generated higher trust among their members. These findings reveal an interesting corrective to more pessimistic view on the relationshipbetween trust and diversity. Data from this study also provide important insight into how bridging between different people in associations marked by diversity can accentuate trust over and above the levels found in associations were bonding between like types is the dominant characteristic. The data also indicate that for both, mono-ethnic and mixed-ethnic associations, it is the extent of members’ involvements in their associations that form trust and not vice versa.

  13. Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome

    Directory of Open Access Journals (Sweden)

    Byun Hyang-Min

    2012-02-01

    Full Text Available Abstract Background Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to affect genome instability. Methods we examined the polymorphic inserted AluYa5, evolutionary young Alu, in the progesterone receptor gene to determine the effects of Alu insertion on molecular environment. We used mono-allelic inserted cell lines which carry both Alu-present and Alu-absent alleles. To determine the epigenetic change and gene expression, we performed restriction enzyme digestion, Pyrosequencing, and Chromatin Immunoprecipitation. Results We observed that the polymorphic insertion of evolutionally young Alu causes increasing levels of DNA methylation in the surrounding genomic area and generates inactive histone tail modifications. Consequently the Alu insertion deleteriously inactivates the neighboring gene expression. Conclusion The mono-allelic Alu insertion cell line clearly showed that polymorphic inserted repetitive elements cause the inactivation of neighboring gene expression, bringing aberrant epigenetic changes.

  14. Mono-dispersed cross-linked polystyrene micro-spheres prepared by seed swelling polymerization method

    Institute of Scientific and Technical Information of China (English)

    Dongsha WANG; Yanjun LIU

    2008-01-01

    A two-step swelling procedure was adopted to synthesize mono-dispersed and highly cross-linked poly (St-divinylbenzene) particles with PSt micro-spheres (1.80 μmin diameter). The PSt micro-spheres were prepared by a dispersion polymerization method and used as seeds. The effects of monomer concentration, ratio of ethanol to water, swelling reagents, crosslinking reagents, swelling temper-ature and agitation speed on particle size were investigated in detail. The morphologies and size distributions of these micro-spheres were examined by SEM and particle size analysis (PSA). The Tg of the micro-spheres was measured by DSC. The results indicate that the particles (6.20 μm in diameter) exhibit excellent mono dispersed property and high crosslinking degree when the concentration of the swelling reagent was 25%, the concentration of the cross-linking reagents was 23%, the swelling temperature was 30℃ and the stirring speed was 150 r/min.

  15. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    Directory of Open Access Journals (Sweden)

    Mohamed T. Ghoneim

    2015-12-01

    Full Text Available In today’s digital world, complementary metal oxide semiconductor (CMOS technology enabled scaling of bulk mono-crystalline silicon (100 based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm mono-crystalline (100 silicon (detached from bulk substrate by utilizing deterministic pattern of porous network of vertical “through silicon” micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs with high-κ/metal gate stacks.

  16. Mono-top Signature from Supersymmetric $t \\bar t H$ Channel

    CERN Document Server

    Gonçalves, Dorival; Takeuchi, Michihisa

    2016-01-01

    We point out that a distinctive mono-top signature is present in Natural SUSY scenarios when a scalar top-quark and higgsinos are almost mass degenerate. This signature originates from a supersymmetric counter part of the $t \\bar t H$ process, i.e. $pp \\to \\tilde t t \\tilde h$. Unlike mono-jet signatures exploiting initial state radiation, this channel can be regarded as a smoking gun signature of a light stop and higgsinos, allowing a direct probe of the stop and neutralino sectors. The production rate of this channel largely depends on the up-type higgsino components in the neutralinos while the stop sector is sensitive to angular distributions of top-quark's decay products. We develop an optimal search strategy to capture the supersymmetric $t \\bar t H$ process and find that a high luminosity LHC can probe the stop and higgsino sectors with $m_{\\tilde t_1} \\lesssim 380$ GeV and $m_{\\tilde t_1} - m_{\\tilde \\chi_1^0} \\lesssim m_W$. Additionally, we propose a kinematic variable with which one can measure the ...

  17. Propellant Grade Hydrazine in Mono/Bi-propellant Thrusters: Preparation and Performance Evaluation

    Directory of Open Access Journals (Sweden)

    S. Krishnamachary

    2015-03-01

    Full Text Available Propellant grade hydrazine was prepared with 64 per cent yield and 95.5 per cent purity. Purity of the propellant grade hydrazine was determined using wet chemical, gas chromatographic (GC and eudiometric methods. It was observed that the compositions containing blends of hydrazine-methyl alcohol-ammonium nitrate and hydrazine-methyl alcohol-ammonium perchlorate were not found to be frozen even after cooling to -65 °C for 30 minutes. Mono and bi-propellant thrusters were designed and developed to demonstrate the performance of prepared propellant grade hydrazine as a promising rocket fuel. Five static tests with 22 N thruster and one static test with 1 N thruster were performed successfully in mono-propellant mode. The hurdles of chamber pressure oscillations were overcome by compact packing of the catalyst. The desired decomposition and chamber pressure were achieved. One static test was performed successfully with 60 N bi-propellant thruster. The desired chamber pressure and thrust were achieved. The combustion was smooth and C* achieved was higher than that of UH-25, N2O4 combination. The performance of prepared propellant grade hydrazine shows it as a promising rocket fuels.Defence Science Journal, Vol. 65, No. 1, January 2015, pp.31-38, DOI:http://dx.doi.org/10.14429/dsj.65.7986

  18. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    Science.gov (United States)

    Ghoneim, Mohamed T.; Fahad, Hossain M.; Hussain, Aftab M.; Rojas, Jhonathan P.; Torres Sevilla, Galo A.; Alfaraj, Nasir; Lizardo, Ernesto B.; Hussain, Muhammad M.

    2015-12-01

    In today's digital world, complementary metal oxide semiconductor (CMOS) technology enabled scaling of bulk mono-crystalline silicon (100) based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm) mono-crystalline (100) silicon (detached from bulk substrate) by utilizing deterministic pattern of porous network of vertical "through silicon" micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs) with high-κ/metal gate stacks.

  19. Potassium-argon ages of recent rhyolites of the Mono and Inyo craters, California

    Science.gov (United States)

    Brent, Dalrymple G.

    1967-01-01

    Twenty-two KAr ages were determined for sanidine samples from 10 rhyolite domes of the Mono and Inyo Craters to test the applicability of KAr dating to volcanic rocks of Recent age. Comparison of the results with 'blank' and dosed analyses shows that radiogenic 40Ar was detected and was measured to within a factor of two or better. The estimated standard deviation of precision is 12% for analyses containing 5% or more radiogenic 40Ar. A statistical analysis suggests that real differences in apparent age were detected between three of the analyzed domes. The ages, which range from 6400 to 10,200 years for experiments with 5% or more radiogenic 40Ar, are, in general, consistent with ionium ages on 5 of the same samples and with glacial and 14C evidence of age. They suggest that most of the Mono Craters volcanos are on the order of 10,000 years old or less. The results also suggest that the problem of excess 40Ar may not be severe for KAr dating of volcanic rocks. ?? 1967.

  20. Rapid identification of vibrio-cholerae O1 by coaglutination test using mono-specifis antibody

    Directory of Open Access Journals (Sweden)

    Bazargan SA

    1996-07-01

    Full Text Available In our investigation, rabbit hyper-immune serum to V.cholerae ogawa was absorbed with V.cholerae inaba whole-cells and vice versa. Applying ammonium sulphate precipitation method, mono-specific g globulins were purified and concentrated from the absorbed whole serum. These antibodies were fixed on staphylococcus cowan 1 NCTC-8325 whole-cells, using different chemical fixatives. It was observed that maximum fixation of g globulin to protein-A was achieved by 1-propanol 50% at 3 hours, which revealed through single radial immuno-diffusion techniqe. The rectal swab samples were cultured in an enrichment bile-peptons broth. After 5 hours 37°C while agitations, one drop of each sample was mixed with one drop of vibrio-cholerae bivalent mono-specific coagglutination reagent (VBCR. The results were read after 2 to 3 minutes. Finally though statistical analysis sensitivity and specificity of coagglutination test were calculated to be 95.1% and 99.2% respectively, when compared to positive & negative controls and conventional culture methods. Using VBCR, coagglutination test can be therefore considered as a simple, reliable and rapid method to detect V.cholerae O1 in the stool of patients in endemic area and less equipped laboratories

  1. Wetting of mono- and polycrystalline tungsten with Ni-Fe-W alloys

    Energy Technology Data Exchange (ETDEWEB)

    Yupko, V.L.; Monastyreva, N.I.; Verkhovodov, P.A.; Minakova, R.V.; Lotsko, D.V.; Nedolyaeva, L.P.; Vojtenko, V.L. (AN Ukrainskoj SSR, Kiev. Inst. Problem Materialovedeniya)

    1984-09-01

    Wetting mono- and polycrystalline tungsten on (111) and (110) faces with Ni-Fe-W alloys is studied in vacuum of 5-10 MPa and hydrogen atmosphere (P/sub H2/) approximately 19 rPa) in the 1760-1920 K range of temperatures during combined and separate heating of substrate and liquid phase. Surface tension and alloy density are measured within 1720-1890 K in helium atmosphere under pressure of 4 MPa. It is shown that difference in wetting of mono- and polycrystalline tungsten on (110) and (111) faces during separate heating in vacuum (1760 K) is in the limits of the experiment error: finite values of Ni-Fe-W alloy contact angles are equal to 1-3 deg independent of composition. Rates of coating of different types of tungsten with alloys of the composition given are also similar and fall with an increase of its content in a liquid phase. It is found that q=1-3 deg during polycrystalline tungsten wetting in the hydrogen atmosphere (1760 K) as well as in vacuum, however coating rates of all alloys are higher. Experiments on joint heating at temperatures 1760, 1820, 1870, 1920 K also confirm identity of wetting of monocrystalline tungsten of (111) and (110) faces and polycrystalline tungsten at all temperatures on all types of substrates q=1-3 deg.

  2. Ca isotope fractionation in a high-alkalinity lake system: Mono Lake, California

    Science.gov (United States)

    Nielsen, Laura C.; DePaolo, Donald J.

    2013-10-01

    Precipitation of calcium carbonate minerals from aqueous solutions causes surface-controlled kinetic stable Ca isotope fractionation. The magnitude of fractionation depends on the relative rates of ion attachment to and detachment from the mineral surface, which in turn is predicted to depend on both the saturation state and the solution stoichiometry or the Ca:CO32- activity ratio. Experimental studies have not directly investigated the effects of varying solution stoichiometry on calcium isotope partitioning during calcite or aragonite growth, but natural alkaline lake systems such as Mono Lake, California provide a test bed for the hypothesized stoichiometry dependence. Mono Lake has a Ca:CO32- activity ratio of about 0.0001, seven orders of magnitude lower than ocean water and typical terrestrial freshwater. We present chemical and isotopic measurements of streams, springs, lake water, and precipitated carbonates from the Mono Basin that yield evidence of stoichiometry-dependent Ca isotope fractionation during calcite, aragonite and Mg-calcite precipitation from the alkaline lake water. To estimate the Ca isotope fractionation factors, it is necessary to characterize the lake Ca balance and constrain the variability of lake water chemistry both spatially and temporally. Streams and springs supply Ca to the lake, and a substantial fraction of this supply is precipitated along the lake shore to form tufa towers. Lake water is significantly supersaturated with respect to carbonate minerals, so CaCO3 also precipitates directly from the water column to form carbonate-rich bottom sediments. Growth rate inhibition by orthophosphate likely preserves the high degree of supersaturation in the lake. Strontium isotope ratios are used to estimate the proportions of fresh and alkaline lake water from which each solid carbonate sample precipitated. Carbonate minerals that precipitate directly from lake water (low Ca:CO32-) experience relatively large Ca isotope fractionation

  3. Parásitos Gastrointestinales en Monos de Margarita Sapajus apella margaritae (Primates: Cebidae en Estado Silvestre (Nueva Esparta, Venezuela. Hallazgos preliminares -resumen-

    Directory of Open Access Journals (Sweden)

    Glencora M Montesinos-López

    2014-12-01

    ásitos y su papel en la ecología de esta especie como hospedadores. Se recomienda evaluar su posible efecto deletéreo en la salud de esta especie mediante evaluación de otros parámetros sanitarios‚ considerando su cercanía geográfica y contacto con poblaciones humanas y con monos mantenidos ilegalmente en cautiverio que son posteriormente liberados al hábitat natural‚ como factores que pueden influenciar el parasitismo en esta población. Este estudio contribuye a sentar las bases para la caracterización y monitoreo del estado sanitario de esta especie amenazada‚ sumándose a los esfuerzos para su conservación.

  4. Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles.

    Science.gov (United States)

    Craig, Zelieann R; Leslie, Traci C; Hatfield, Kimberly P; Gupta, Rupesh K; Flaws, Jodi A

    2010-12-01

    Methoxychlor (MXC) is an organochlorine pesticide that reduces fertility in female rodents by decreasing antral follicle numbers and increasing follicular death. MXC is metabolized in the body to mono-hydroxy MXC (mono-OH). Little is known about the effects of mono-OH on the ovary. Thus, this work tested the hypothesis that mono-OH exposure decreases production of 17β-estradiol (E₂) by cultured mouse antral follicles. Antral follicles were isolated from CD-1 mice (age 35-39 days) and exposed to dimethylsulfoxide (DMSO), or mono-OH (0.1-10 μg/mL) for 96 h. Media and follicles were collected for analysis of sex steroid levels and mRNA expression, respectively. Mono-OH treatment (10 μg/mL) decreased E(2) (DMSO: 3009.72±744.99 ng/mL; mono-OH 0.1 μg/mL: 1679.66±461.99 ng/mL; 1 μg/mL: 1752.72±532.41 ng/mL; 10 μg/mL: 45.89±33.83 ng/mL), testosterone (DMSO: 15.43±2.86 ng/mL; mono-OH 0.1μg/mL: 17.17±4.71 ng/mL; 1 μg/mL: 13.64±3.53 ng/mL; 10 μg/mL: 1.29±0.23 ng/mL), androstenedione (DMSO: 1.92±0.34 ng/mL; mono-OH 0.1 μg/mL: 1.49±0.43ng/mL; 1 μg/mL: 0.64±0.31 ng/mL; 10 μg/mL: 0.12±0.06 ng/mL) and progesterone (DMSO: 24.11±4.21 ng/mL; mono-OH 0.1μg/mL: 26.77±4.41 ng/mL; 1 μg/mL: 20.90±3.75 ng/mL; 10 μg/mL: 9.44±2.97 ng/mL) levels. Mono-OH did not alter expression of Star, Hsd3b1, Hsd17b1 and Cyp1b1, but it did reduce levels of Cyp11a1, Cyp17a1 and Cyp19a1 mRNA. Collectively, these data suggest that mono-OH significantly decreases levels of key sex steroid hormones and the expression of enzymes required for steroidogenesis.

  5. Missing particle associated with two bottom quarks at the LHC: Mono-$b$ versus 2$b$ with razor variables

    CERN Document Server

    Chen, Ning; Li, Jinmian

    2016-01-01

    The extended Higgs sector such as by a second Higgs doublet of type-II provides portals to dark sector which contains missing particles at the LHC, e.g., dark matter (DM) particle. In this paper, working in the simplified model and taking into consideration the vital wide width effect of the mediator, we analyze the characteristic signatures of mono-$b$+MET and 2$b$+MET at the LHC. The latter signature was believed to be ineffective, but we found that, with the aid of razor shape analysis, it should be as important as the mono-$b$ signature. In the region of relatively low mediator mass (below a few hundred GeV), the 2$b$-tagged razor analysis has comparable sensitivity with the mono-$b$ search when the systematic uncertainty is at percent level; it is even better for mediator lighter than $\\sim 200$ GeV.

  6. Prediction of gas chromatographic retention times of polychlorinated biphenyls by mono-dimensional molecular descriptors and multivariate techniques

    Energy Technology Data Exchange (ETDEWEB)

    Mecozzi, M.; Amici, M. [Istituto Centrale per la Ricerca Scientifica e Technological Applicata al Mare, Rome (Italy); Acquistucci, R. [Istituto Nazionale per la Nutrizione e gli Alimenti, Rome (Italy)

    2003-07-01

    We report a procedure for describing the gas chromatographic retention time of polychlorinated biphenyls (PCBs) as a function of simple mono-dimensional molecular descriptors such as the number and position of chlorine atoms on the aromatic rings. The mathematical relationships between relative retention time (RRT) of all 209 possible congeners of PCBs and the mono-dimensional molecular descriptors (MDDs) were obtained by the multivariate techniques principal component regression (PCR) and partial least squares (PLS) used as modelling tools. The good agreement found between experimental and predicted retention times of PCBs shows that a well established mathematical model relating retention time to specific mono-dimensional molecular descriptors can be a useful tool to enhance identification of these pollutants in real samples. (orig.)

  7. Magmatic gas emissions at Holocene volcanic features near Mono Lake, California, and their relation to regional magmatism

    Science.gov (United States)

    Bergfeld, Deborah; Evans, William C.; Howle, James F.; Hunt, Andrew G.

    2015-02-01

    Silicic lavas have erupted repeatedly in the Mono Basin over the past few thousand years, forming the massive domes and coulees of the Mono Craters chain and the smaller island vents in Mono Lake. We report here on the first systematic study of magmatic CO2 emissions from these features, conducted during 2007-2010. Most notably, a known locus of weak steam venting on the summit of North Coulee is actually enclosed in a large area (~ 0.25 km2) of diffuse gas discharge that emits 10-14 t/d of CO2, mostly at ambient temperature. Subsurface gases sampled here are heavily air-contaminated, but after standard corrections are applied, show average δ13C-CO2 of - 4.72‰, 3He/4He of 5.89RA, and CO2/3He of 0.77 × 1010, very similar to the values in fumarolic gas from Mammoth Mountain and the Long Valley Caldera immediately to the south of the basin. If these values also characterize the magmatic gas source at Mono Lake, where CO2 is captured by the alkaline lake water, a magmatic CO2 upflow beneath the lake of ~ 4 t/d can be inferred. Groundwater discharge from the Mono Craters area transports ~ 13 t/d of 14C-dead CO2 as free gas and dissolved carbonate species, and adding in this component brings the estimated total magmatic CO2 output to 29 t/d for the two silicic systems in the Mono Basin. If these emissions reflect intrusion and degassing of underlying basalt with 0.5 wt.% CO2, a modest intrusion rate of 0.00075 km3/yr is indicated. Much higher intrusion rates are required to account for CO2 emissions from Mammoth Mountain and the West Moat of the Long Valley Caldera.

  8. Long-term thermophilic mono-digestion of rendering wastes and co-digestion with potato pulp

    Energy Technology Data Exchange (ETDEWEB)

    Bayr, S., E-mail: suvi.bayr@jyu.fi; Ojanperä, M.; Kaparaju, P.; Rintala, J.

    2014-10-15

    Highlights: • Rendering wastes’ mono-digestion and co-digestion with potato pulp were studied. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was unstable in mono-digestion. • Free NH{sub 3} inhibited mono-digestion of rendering wastes. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was stable in co-digestion. • Co-digestion increased methane yield somewhat compared to mono-digestion. - Abstract: In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55 °C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion intermediate products viz., volatile fatty acids (VFAs), long chain fatty acids (LCFAs) and ammonia nitrogen (NH{sub 4}-N and/or free NH{sub 3}) can cause process imbalance during the digestion. Mono-digestion of rendering wastes at an organic loading rate (OLR) of 1.5 kg volatile solids (VS)/m{sup 3} d and hydraulic retention time (HRT) of 50 d was unstable and resulted in methane yields of 450 dm{sup 3}/kg VS{sub fed}. On the other hand, co-digestion of rendering wastes with potato pulp (60% wet weight, WW) at the same OLR and HRT improved the process stability and increased methane yields (500–680 dm{sup 3}/kg VS{sub fed}). Thus, it can be concluded that co-digestion of rendering wastes with potato pulp could improve the process stability and methane yields from these difficult to treat industrial waste materials.

  9. Acid-Catalysed Conversion of Saccharides into Furanic Aldehydes in the Presence of Three-Dimensional Mesoporous Al-TUD-1

    Directory of Open Access Journals (Sweden)

    Sérgio Lima

    2010-05-01

    Full Text Available The one-pot acid-catalysed conversion of mono/di/polysaccharides (inulin, xylan, cellobiose, sucrose, glucose, fructose, xylose into 2-furfuraldehyde (FUR or 5-hydroxymethylfurfural (HMF in the presence of aluminium-containing mesoporous TUD-1 (denoted as Al-TUD-1, Si/Al = 21, at 170 ºC was investigated. Xylose gave 60% FUR yield after 6 h reaction; hexose-based mono/disaccharides gave less than 20% HMF yield; polysaccharides gave less than 20 wt % FUR or HMF yields after 6 h. For four consecutive 6 h batches of the xylose reaction in the presence of Al-TUD-1, the FUR yields achieved were similar, without significant changes in Si/Al ratio.

  10. Assessing Li and other leachable geochemical proxies for paleo-salinity in lake sediments from the Mono Basin, CA (USA)

    Science.gov (United States)

    Sahajpal, Rahul; Zimmerman, Susan R. H.; Datta, Saugata; Hemming, N. Gary; Hemming, Sidney R.

    2011-12-01

    Regional climate-driven hydrological changes are accompanied by salinity changes in closed basin lakes. We have investigated acid leachable Li, along with other leachable ions including Mg, Ca and Sr, as geochemical proxies of salinity in lake sediments in the Mono Basin, California. All the elements in the acid leachable suite show a strong correlation with paleo-lake level estimates based on physical and stratigraphic evidence. The CaCO 3 content of lake sediments, which has been shown to be a reliable proxy for lake level changes in the Mono basin and the adjoining Owens Lake basin, corresponds well with our acid-leachable proxy data.

  11. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor.

    Science.gov (United States)

    Craig, Zelieann R; Hannon, Patrick R; Flaws, Jodi A

    2013-11-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P4) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P4, androstenedione (A), testosterone (T), estrone (E1), and 17β-estradiol (E2) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E2. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P4, A, T, and E1 that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival.

  12. Lake Level Changes in the Mono Basin During the Last Deglacial Period

    Science.gov (United States)

    Wang, X.; Ali, G.; Hemming, S. R.; Zimmerman, S. R. H.; Stine, S. W.; Hemming, G.

    2014-12-01

    Mono Basin, located in the southwestern corner of the US Great Basin, has long been known to have experienced large lake level changes, particularly during the last deglaciation. But until recently it was not possible to establish a reliable lake level time series. We discovered many visually clean, white, shiny, dense calcite samples in the basin, associated with tufa deposits from high terraces. Their low thorium, but high uranium contents allow precise and reproducible U/Th age determinations. A highly resolved history of a minimum lake level through the last deglaciation can therefore be inferred based on sample locations and their ages. We found that the lake level reached ~2030 m asl at ~20.4 ka, evidenced by calcite coatings on a tufa mound at the upper Wilson Creek. The lake then rose to ~2075 m by ~19.1 ka, shown by calcite cements on conglomerates from the Hansen Cut terrace. The lake climbed to at least ~2140 m at ~15.9 ka, indicated by beach calcites from the east Sierra slope. Such timing of the highest lake stand, occurring within Heinrich Stadial 1, is reinforced by U/Th dates on calcite coatings from widespread locations in the basin, including the Bodie Hills and Cowtrack Mountains. The lake then dropped rapidly to ~2075 m at ~14.5 ka. It stood near this height over the next ~300 years, evidenced by a few-centimeter thick, laminated calcite rims on the Goat Ranch tufa mounds. It subsequently plunged to ~2007 m at ~13.8 ka, indicated by calcite coatings from cemetery road tufa mounds. The lake level came back to ~2030 m at ~12.9 ka, as seen in upper Wilson Creek tufa mounds. The lake level had a few fluctuations within the Younger Dryas, and even shot up to ~2075 m at ~12.0 ka. It then fell to levels in accord with Holocene climatic conditions. Relative to the present lake level of ~1950 m, Mono Lake broadly stood high during Heinrich Stadial 1 and Younger Dryas, when the climate was extremely cold over the North Atlantic, and the Asian monsoon was

  13. Avaliação da pressão arterial sistêmica em cães obesos: comparação entre os métodos oscilométrico e doppler ultrassônico

    OpenAIRE

    Pereira-Neto, Gláucia B.; Brunetto, Márcio A.; Tatiana Champion; Edna M.G. Ortiz; Aulus C. Carciofi; Aparecido A. Camacho

    2014-01-01

    Resumo: A obesidade é o problema nutricional que mais acomete os cães e pode causar vários efeitos deletérios a saúde animal. No entanto, o efeito desta condição sobre a pressão arterial sistólica (PAS) em cães obesos é controverso. Os métodos indiretos de mensuração da PAS são os mais comumente utilizados na medicina veterinária para o diagnóstico da hipertensão sistêmica, por serem mais práticos e de fácil acesso. Não foram localizados na literatura estudos que tenham comparado os dois méto...

  14. Problematização como estratégia de educação nutricional com adolescentes obesos Problem-posing as a nutritional education strategy with obese teenagers

    Directory of Open Access Journals (Sweden)

    Érika Marafon Rodrigues

    2006-05-01

    Full Text Available Obesidade é um problema de saúde pública em cuja etiologia determinantes sociais têm relevância, sendo que intervenções com adolescentes encontram condição biopsicossocial complexa. A pesquisa avaliou intervenção de educação nutricional, empregando o método da problematização, com 22 adolescentes obesos, atendidos coletiva e individualmente, durante oito meses. Falas foram coletadas mediante emprego de tarjetas, registro por observador e gravação. O método foi qualitativo e a técnica, a análise de conteúdo. A problematização mostrou-se instrumento facilitador para mudança de comportamento alimentar, fazendo emergir reflexões sobre: práticas alimentares, contexto familiar, estigma social, relacionamento com profissionais de saúde, religiosidade. Os adolescentes em atendimento individual problematizaram com mais efetividade práticas alimentares, enquanto no coletivo houve maior problematização dos aspectos familiares e psicológicos, com efetivas mudanças qualitativas na alimentação de ambos os grupos. Concluiu-se que a intervenção foi eficaz para ajudar os adolescentes a compreenderem sua história de vida e determinantes do comportamento alimentar, efetivarem mudanças na sua alimentação espontaneamente, conscientizarem-se das possibilidades de perpetuação da mudança das práticas alimentares e exercerem com autonomia o papel de sujeitos no cuidado à saúde.Obesity is a public health issue with relevant social determinants in its etiology and where interventions with teenagers encounter complex biopsychological conditions. This study evaluated intervention in nutritional education through a problem-posing approach with 22 obese teenagers, treated collectively and individually for eight months. Speech acts were collected through the use of word cards, observer recording, and tape-recording. The study adopted a qualitative methodology, and the approach involved content analysis. Problem-posing facilitated

  15. Análise da função respiratória em pacientes obesos submetidos à operação Fobi-Capella Respiratory function in obese patients submitted to Fobi-Capella operation

    Directory of Open Access Journals (Sweden)

    Áurea Maria Oliveira da Silva

    2007-10-01

    Full Text Available INTRODUÇÃO: O objetivo deste trabalho foi mensurar quantitativamente essas alterações respiratórias desses pacientes comparando-os até 30 dias de pós-operatório. MÉTODO: Foram realizadas avaliações respiratórias nos períodos pré e pós-operatório de cirurgia bariátrica em obesos mórbidos com IMC superior a 39kg/m², através de gasometria arterial, prova de função respiratória, manovacuômetria, incentivador da respiração e cirtometrias. Foram realizadas também orientações fisioterápicas respiratórias e tratamento no pós-operatório, com dados comparativos entre as avaliações feitas no préoperatório, no 1º, 14º·e 30º dia pós-operatórios. RESULTADOS: Até o 30º dia de pós-operatório, esses indivíduos não obtiveram diferença significativa nos parâmetros estudados, não havendo, em decorrência do tratamento fisioterápico, complicações respiratórias. CONCLUSÃO: Não houve alterações dos parâmetros analisados, nem complicações respiratórias neste estudo com intervenção fisioterápica pré e pós-operatório de cirurgia bariátrica. Estudos devem ser realizados, para mensuração de um tempo maior de pós-operatório e de exercícios específicos, podendo, assim apresentar resultados diferentes.BACKGROUND: The objective this study was to measure quantitatively those breathing alterations until 30 days postoperative. METHOD: Breathing evaluations were accomplished before and after bariatric surgery, in morbid obese with IMC greater than 39 kg/m², through arterial gasometry, spirometry function, manovacuometry, to motivate breathing and circumferences. They were breathing physiotherapeutic accomplished, orientations and treatment in the postoperative, with comparative data among evaluations in the 1st, 14th ·e 30th postoperative day. RESULTS: Until the 30th postoperative day, those individuals didn't achieve significant differences in the evaluated parameters, and showed no breathing

  16. Sources of SOA gaseous precursors in contrasted urban environments: a focus on mono-aromatic compounds and intermediate volatility compounds

    Science.gov (United States)

    Salameh, Therese; Borbon, Agnès; Ait-Helal, Warda; Afif, Charbel; Sauvage, Stéphane; Locoge, Nadine; Bonneau, Stéphane; Sanchez, Olivier

    2016-04-01

    Among Volatile Organic Compounds (VOC), the mono-aromatic compounds so-called BTEX (Benzene, Toluene, Ethylbenzene, and Xylenes) and the intermediate volatility organic compounds (IVOC) with C>12 are two remarkable chemical families having high impact on health, as well as on the production of secondary pollutants like secondary organic aerosols (SOA) and ozone. However, the nature and relative importance of their sources and, consequently, their impact on SOA formation at urban scale is still under debate. On the one hand, BTEX observations in urban areas of northern mid-latitudes do not reconcile with emission inventories; the latter pointing to solvent use as the dominant source compared to traffic. Moreover, a recent study by Borbon et al. (2013) has shown an enrichment in the C7-C9 aromatic fraction in Paris atmosphere by a factor of 3 compared to other cities. Causes would be: (i) differences in gasoline composition, (ii) differences in vehicle fleet composition, and (iii) differences in solvent use related sources. On the other hand, many smog chamber studies have highlighted IVOCs as important SOA precursors over the last decade but their origin and importance in urban areas relative to other precursors like BTEX is still poorly addressed. Here we combined large VOC datasets to investigate sources of BTEX and IVOC in contrasted urban areas by source-receptor approaches and laboratory experiments. Ambient data include multi-site speciated ambient measurements of C2 to C17 VOCs (traffic, urban background, and tunnel) from air quality networks (ie. AIRPARIF in Paris) and intensive field campaigns (MEGAPOLI-Paris, TRANSEMED in Beirut and Istanbul, PHOTOPAQ in Brussels). Preliminary results for Paris suggest that traffic dominates BTEX concentrations while traffic and domestic heating for IVOC (>70%). In parallel, the detailed composition of the fuel liquid phase was determined at the laboratory for typical fuels distributed in Ile de France region (diesel, SP95

  17. Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands.

    Science.gov (United States)

    Richter, Stefan; Singh, Sushma; Draca, Dijana; Kate, Anup; Kumbhar, Anupa; Kumbhar, Avinash S; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Lönnecke, Peter; Hey-Hawkins, Evamarie

    2016-08-16

    A series of Ru(II) arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division. PMID:27264161

  18. A Quantum Monte Carlo Study of mono(benzene)TM and bis(benzene)TM Systems

    CERN Document Server

    Bennett, M Chandler; Mitas, Lubos

    2016-01-01

    We present a study of mono(benzene)TM and bis(benzene)TM systems, where TM={Mo,W}. We calculate the binding energies by quantum Monte Carlo (QMC) approaches and compare the results with other methods and available experiments. The orbitals for the determinantal part of each trial wave function were generated from several types of DFT in order to optimize for fixed-node errors. We estimate and compare the size of the fixed-node errors for both the Mo and W systems with regard to the electron density and degree of localization in these systems. For the W systems we provide benchmarking results of the binding energies, given that experimental data is not available.

  19. Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

    Directory of Open Access Journals (Sweden)

    Stefano D'Errico

    2014-07-01

    Full Text Available The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyladenosine or a 1,6-di(adenosin-N6-yl-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamineplatinum(II, is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.

  20. Derivation of the low Mach number diphasic system. Numerical simulation in mono-dimensional geometry

    International Nuclear Information System (INIS)

    This work deals with the derivation of a diphasic low Mach number model obtained through a Mach number asymptotic expansion applied to the compressible diphasic Navier Stokes system, expansion which filters out the acoustic waves. This approach is inspired from the work of Andrew Majda giving the equations of low Mach number combustion for thin flame and for perfect gases. When the equations of state verify some thermodynamic hypothesis, we show that the low Mach number diphasic system predicts in a good way the dilatation or the compression of a bubble and has equilibrium convergence properties. Then, we propose an entropic and convergent Lagrangian scheme in mono-dimensional geometry when the fluids are perfect gases and we propose a first approach in Eulerian variables where the interface between the two fluids is captured with a level set technique. (author)

  1. The Aerobic Biodegradability of Mono-fluorophenols by the Activated Sludge

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chao-jie; ZHOU Qi; CHEN Ling; YUAN Yuan

    2006-01-01

    By measuring the respiratory oxygen consumption, a study on the aerobic biodegradability of 2-fluorophenol, 3-fluorophenol and 4-fluorophenol was conducted using activated sludge acclimated by themselves respectively. The experimental results showed that bio-oxidation ratios of 2-fluorophenol, 3- fluorophenol and 4- fluorophenol were 25.30%, 35.28% and 36. 60% respectively, and the oxygen consuming rate constants were 0.009 3, 0.0133 and 0.0145 L/gSS· h respectively. The aerobic biodegradability of the mono-fluorophenols decreased in the order of 4- fluorophenol>3 - fluorophenol >2 - fluorophenol, resulting mainly from the different octanol/water partition coefficient and the different steric parameter of the fluorophenols which can affect the penetration of fluorophenol into cell membrane.

  2. Formation and spectroscopic characterization of mono-dispersed CdSe nanocrystals

    Institute of Scientific and Technical Information of China (English)

    Miao Yan-Ming; Li Chao-Rong; Cao Li; Liu Rui-Bin; He Yu-Ping; Xie Si-Shen; Zou Bing-Suo

    2005-01-01

    In this article, mono-dispersed hexagonal structure CdSe nanocrystals with polyhedron shape were prepared by an open solvent thermal reaction. They show a discrete excitonic transition structure in the absorption spectra and the minimal photoluminescence (PL) peak full-width at half-maximum of 19nm. The PL quantum yield is about 60%. Transmission electron micrographs, high-resolution transmission electron micrographs, x-ray powder diffraction patterns, UV-vis absorption spectra and PL spectra were obtained for the as-prepared CdSe nanocrystals. The size of the CdSe nanocrystals can be tuned by changing the reaction temperature or time. Due to the improved synthesis method, a different growth mechanism of the CdSe nanocrystals is discussed.

  3. Bottom-up formation of endohedral mono-metallofullerenes is directed by charge transfer

    Science.gov (United States)

    Dunk, Paul W.; Mulet-Gas, Marc; Nakanishi, Yusuke; Kaiser, Nathan K.; Rodríguez-Fortea, Antonio; Shinohara, Hisanori; Poblet, Josep M.; Marshall, Alan G.; Kroto, Harold W.

    2014-12-01

    An understanding of chemical formation mechanisms is essential to achieve effective yields and targeted products. One of the most challenging endeavors is synthesis of molecular nanocarbon. Endohedral metallofullerenes are of particular interest because of their unique properties that offer promise in a variety of applications. Nevertheless, the mechanism of formation from metal-doped graphite has largely eluded experimental study, because harsh synthetic methods are required to obtain them. Here we report bottom-up formation of mono-metallofullerenes under core synthesis conditions. Charge transfer is a principal factor that guides formation, discovered by study of metallofullerene formation with virtually all available elements of the periodic table. These results could enable production strategies that overcome long-standing problems that hinder current and future applications of metallofullerenes.

  4. Metabolism of UC-labelled urea in conventional, germ-free and mono-associated rats

    Energy Technology Data Exchange (ETDEWEB)

    Juhr, N.C.; Franke, J.

    1987-01-01

    This report deals with the utilization of UC-labelled urea in conventional, defined associated and germ-free rats. With conventional animals 71.44% of the administered UC dose can be demonstrated in the exhaled air, 0.47% in organs and 27.35% in the urine. 1.04% was found in the intestinal and fecal contents. Animals mono-associated with Proteus mirabilis have nearly the same utilization rate (59.15, 0.34, 35.98, 2% resp.). In germ-free animals 1.21% of the activity appeared in the exhaled air and showed a small part of non-enzymatic hydrolysis of urea. The excretion of 97.70% in the urine shows that urea is absorbed from the intestine in germ-free animals.

  5. Surface-Controlled Mono/Diselective ortho C-H Bond Activation.

    Science.gov (United States)

    Li, Qing; Yang, Biao; Lin, Haiping; Aghdassi, Nabi; Miao, Kangjian; Zhang, Junjie; Zhang, Haiming; Li, Youyong; Duhm, Steffen; Fan, Jian; Chi, Lifeng

    2016-03-01

    One of the most charming and challenging topics in organic chemistry is the selective C-H bond activation. The difficulty arises not only from the relatively large bond-dissociation enthalpy, but also from the poor reaction selectivity. In this work, Au(111) and Ag(111) surfaces were used to address ortho C-H functionalization and ortho-ortho couplings of phenol derivatives. More importantly, the competition between dehydrogenation and deoxygenation drove the diversity of reaction pathways of phenols on surfaces, that is, diselective ortho C-H bond activation on Au(111) surfaces and monoselective ortho C-H bond activation on Ag(111) surfaces. The mechanism of this unprecedented phenomenon was extensively explored by scanning tunneling microscopy, density function theory, and X-ray photoelectron spectroscopy. Our findings provide new pathways for surface-assisted organic synthesis via the mono/diselective C-H bond activation. PMID:26853936

  6. Phase Separation of Saturated and Mono-unsaturated Lipids as determined from a Microscopic Model

    CERN Document Server

    Elliott, R; Schick, M; Szleifer, I

    2004-01-01

    A molecular model is proposed of a bilayer consisting of fully saturated DPPC and mono unsaturated DOPC. The model not only encompasses the constant density within the hydrophobic core of the bilayer, but also the tendency of chain segments to align. It is solved within self-consistent field theory. A model bilayer of DPPC undergoes a main chain transition to a gel phase, while a bilayer of DOPC does not do so above zero degrees centigrade because of the double bond which disrupts order. We examine structural and thermodynamic properties of these membranes and find our results in reasonable accord with experiment. In particular, order-parameter profiles are in good agreement with NMR experiments. A phase diagram is obtained for mixtures of these lipids in a membrane at zero tension. The system undergoes phase separation below the main-chain transition temperature of the saturated lipid. Extensions to the ternary DPPC, DOPC, and cholesterol system are outlined.

  7. Entire solutions for a mono-stable delay population model in a 2D lattice strip

    Directory of Open Access Journals (Sweden)

    Hai-Qin Zhao

    2014-11-01

    Full Text Available This article concerns the entire solutions of a mono-stable age-structured population model in a 2D lattice strip. In a previous publication, we established the existence of entire solutions related to traveling wave solutions with speeds larger than the minimal wave speed $c_{\\rm min}$. However, the existence of entire solutions related to the minimal wave fronts remains open open question. In this article, we first establish a new comparison theorem. Then, applying the theorem we obtain the existence of entire solutions by mixing any finite number of traveling wave fronts with speeds $c\\geq c_{\\rm min}$, and a solution without the $j$ variable. In particular, we show the relationship between the entire solution and the traveling wave fronts that they originate.

  8. Nonlinear optical response of tetra and mono substituted zinc phthalocyanine complexes

    Energy Technology Data Exchange (ETDEWEB)

    Fashina, Adedayo; Nyokong, Tebello, E-mail: t.nyokong@ru.ac.za

    2015-11-15

    The nonlinear absorption properties of 6 mono-substituted and 3 symmetric zinc phthalocyanine complexes have been studied in dimethylsulfoxide (DMSO) using 10 ns pulses at 532 nm. The non linear absorption of the complexes has been studied using the Z-scan technique. The study showed that both the singlet and triplet excited states contribute to the non linear absorption behavior. The nonlinear third-order susceptibility and second-order hyperpolarizability values of the complexes are reported. It was observed that two of the symmetric phthalocyanine complexes (5-α substituted with aminophenoxy and 9-β substituted with carboxyphenoxy) showed better and promising optical nonlinearity when compared to the other complexes studied. - Highlights: • Nonlinear absorption properties of zinc phthalocyanine are reported • Singlet and triplet excited states contribute to the non linear absorption. • Symmetrically tetra substituted phthalocyanines showed better optical nonlinearity.

  9. On the semimetal-insulator transition and Lifshitz transition in simulations of mono-layer graphene

    CERN Document Server

    Smith, Dominik; von Smekal, Lorenz

    2014-01-01

    We report on the status of ongoing Hybrid-Monte-Carlo simulations of the tight-binding model of mono-layer graphene. We present results concerning the semimetal-insulator phase transition, whereby two-body interactions are modeled by a partially screened Coulomb potential which takes into account screening by electrons in the lower $\\sigma$-orbitals. We obtain evidence that finite-size effects may still be present in the current estimate of the critical coupling strength $\\alpha_C$, which was previously extracted from simulations on lattice-sizes up to $N_x=N_y=18$. We also present preliminary results concerning the Neck-disrupting Lifshitz transition which occurs at finite Fermion-density in the limit of vanishing two-body interactions. A sign-problem is circumvented by using a spin-dependent chemical potential in our simulations.

  10. Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.

    Science.gov (United States)

    Rieser, M J; Gu, Z M; Fang, X P; Zeng, L; Wood, K V; McLaughlin, J L

    1996-02-01

    Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). Three of these (1-3) are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. NMR analyses of published model synthetic compounds, prepared cyclized formal acetals, and prepared Mosher ester derivatives permitted the determinations of absolute stereochemistries. Bioassays of the pure compounds, in the brine shrimp test, for the inhibition of crown gall tumors, and in a panel of human solid tumor cell lines for cytotoxicity, evaluated relative potencies. Compound 1 was selectively cytotoxic to colon adenocarcinoma cells (HT-29) in which it was 10,000 times the potency of adriamycin.

  11. Mono- and bi-functional arenethiols as surfactants for gold nanoparticles: synthesis and characterization

    Directory of Open Access Journals (Sweden)

    Fratoddi Ilaria

    2011-01-01

    Full Text Available Abstract Stable gold nanoparticles stabilized by different mono and bi-functional arenethiols, namely, benzylthiol and 1,4-benzenedimethanethiol, have been prepared by using a modified Brust's two-phase synthesis. The size, shape, and crystalline structure of the gold nanoparticles have been determined by high-resolution electron microscopy and full-pattern X-ray powder diffraction analyses. Nanocrystals diameters have been tuned in the range 2 ÷ 9 nm by a proper variation of Au/S molar ratio. The chemical composition of gold nanoparticles and their interaction with thiols have been investigated by X-ray photoelectron spectroscopy. In particular, the formation of networks has been observed with interconnected gold nanoparticles containing 1,4-benzenedimethanethiol as ligand.

  12. Planar Position Sensor Based on Mono Sensing Electrode and Hybrid-Frequency Excitation.

    Science.gov (United States)

    Yu, Hongxiang; Zhang, Yu; Shen, Mengfeng; Zhang, Hongli; Gao, Zhao; Wang, Dongyun

    2016-01-01

    A new way of measuring planar position for micrometric and sub-micrometric applications is presented with a mono sensing electrode and hybrid-frequency excitation. The sensing theory and operation principle are described and summarized, and a printed circuit board (PCB) sensor prototype is built and tested. It is shown by the experimental results that a very simple structure and geometric relationship are achieved. Meanwhile, displacement sensitivity on an order of 1.50 mV per micron and measurement repeatability better than 0.002 mm are easily fulfilled for a square zone of 256 mm², making it a valuable alternative measurement device candidate for flexible and low-cost planar position detection.

  13. A study on the clinical profile of complicated Plasmodium vivax mono-infections

    Institute of Scientific and Technical Information of China (English)

    Peter George; Lobo Manuel Alexander

    2010-01-01

    Objective:To identify cases of severe Plasmodium vivax (P. vivax) mono-infections among adults. Methods:In this retrospective study, 30 adult patients admitted to medical wards of a tertiary hospital in a malaria endemic urban area from March 2010 to April 2010 were included. The diagnosis of P. vivax malaria was established by peripheral blood film (PBF) examination, and severe malaria was categorized as per World Health Organization guidelines. Results:Complications observed were thrombocytopenia in 28 (93.3%), hepatic dysfunction and jaundice in 13 (43.3%), renal dysfunction in 8 (26.7%), severe anaemia in 3 (10.0%), cerebral malaria in 2 (6.7%), and acute respiratory distress syndrome (ARDS) in 1 (3.3%) of 30 patients. Conclusions:P. vivax malaria with severe complications is common in the investigated area, and an intensive and large-scale study of the disease is necessary.

  14. 21 CFR 582.4101 - Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4101 Section 582.4101 Food and... Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat-forming fatty acids. (a) Product. Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils,...

  15. Mono- to few-layered graphene oxide embedded randomness assisted microcavity amplified spontaneous emission source

    Science.gov (United States)

    Das, Pratyusha; Maiti, Rishi; Barman, Prahalad K.; Ray, Samit K.; Shivakiran, Bhaktha B. N.

    2016-02-01

    The realization of optoelectronic devices using two-dimensional materials such as graphene and its intermediate product graphene oxide (GO) is extremely challenging owing to the zero band gap of the former. Here, a novel amplified spontaneous emission (ASE) system based on a GO-embedded all-dielectric one-dimensional photonic crystal (1DPhC) micro-resonator is presented. The mono- to few-layered GO sheet is inserted within a microcavity formed by two 5-bilayered SiO2/SnO2 Bragg reflectors. Significantly enhanced photoluminescence (PL) emission of GO embedded in 1DPhC is explicated by studying the electric field confined within the micro-resonator using the transfer matrix method. The inherent randomness, due to fabrication limitations, in the on-average periodic 1DPhC is exploited to further enhance the PL of the optically active micro-resonator. The 1DPhC and randomness assisted field confinement reduces the ASE threshold of the mono- to few-layered weak emitter making the realization of an ASE source feasible. Consequently, ASE at the microcavity resonance and at the low-frequency band-edge of photonic stop-band is demonstrated. Variation of the detection angle from 5° to 30°, with respect to the sample surface normal allows reallocation of the defect mode ASE peak over a spectral range of 558-542 nm, making the GO-incorporated 1DPhC a novel and attractive system for integrated optic applications.

  16. Characterization of microbial arsenate reduction in the anoxic bottom waters of Mono Lake, California

    Science.gov (United States)

    Hoeft, S.E.; Lucas, F.; Hollibaugh, J.T.; Oremland, R.S.

    2002-01-01

    Dissimilatory reduction of arsenate (DAsR) occurs in the arsenic-rich, anoxic water column of Mono Lake, California, yet the microorganisms responsible for this observed in situ activity have not been identified. To gain insight as to which microorganisms mediate this phenomenon, as well as to some of the biogeochemical constraints on this activity, we conducted incubations of arsenate-enriched bottom water coupled with inhibition/amendment studies and Denaturing Gradient Gel Electrophoresis (DGGE) characterization techniques. DAsR was totally inhibited by filter-sterilization and by nitrate, partially inhibited (~50%) by selenate, but only slightly (~25%) inhibited by oxyanions that block sulfate-reduction (molybdate and tungstate). The apparent inhibition by nitrate, however, was not due to action as a preferred electron acceptor to arsenate. Rather, nitrate addition caused a rapid, microbial re-oxidation of arsenite to arsenate, which gave the overall appearance of no arsenate loss. A similar microbial oxidation of As(III) was also found with Fe(III), a fact that has implications for the recycling of As(V) in Mono Lake's anoxic bottom waters. DAsR could be slightly (10%) stimulated by substrate amendments of lactate, succinate, malate, or glucose, but not by acetate, suggesting that the DAsR microflora is not electron donor limited. DGGE analysis of amplified 16S rDNA gene fragments from incubated arsenate-enriched bottom waters revealed the presence of two bands that were not present in controls without added arsenate. The resolved sequences of these excised bands indicated the presence of members of the epsilon (Sulfurospirillum) and delta (Desulfovibrio) subgroups of the Proteobacteria, both of which have representative species that are capable of anaerobic growth using arsenate as their electron acceptor.

  17. Analysis of Gas Membrane Ultra-High Purification of Small Quantities of Mono-Isotopic Silane

    Energy Technology Data Exchange (ETDEWEB)

    de Almeida, Valmor F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Chemical Sciences Division; Hart, Kevin J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Chemical Sciences Division

    2016-09-05

    A small quantity of high-value, crude, mono-isotopic silane is a prospective gas for a small-scale, high-recovery, ultra-high membrane purification process. This is an unusual application of gas membrane separation for which we provide a comprehensive analysis of a simple purification model. The goal is to develop direct analytic expressions for estimating the feasibility and efficiency of the method, and guide process design; this is only possible for binary mixtures of silane in the dilute limit which is a somewhat realistic case. Among the common impurities in crude silane, methane poses a special membrane separation challenge since it is chemically similar to silane. Other potential problematic surprises are: ethylene, diborane and ethane (in this order). Nevertheless, we demonstrate, theoretically, that a carefully designed membrane system may be able to purify mono-isotopic, crude silane to electronics-grade level in a reasonable amount of time and expenses. We advocate a combination of membrane materials that preferentially reject heavy impurities based on mobility selectivity, and light impurities based on solubility selectivity. We provide estimates for the purification of significant contaminants of interest. To improve the separation selectivity, it is advantageous to use a permeate chamber under vacuum, however this also requires greater control of in-leakage of impurities in the system. In this study, we suggest cellulose acetate and polydimethylsiloxane as examples of membrane materials on the basis of limited permeability data found in the open literature. We provide estimates on the membrane area needed and priming volume of the cell enclosure for fabrication purposes when using the suggested membrane materials. These estimates are largely theoretical in view of the absence of reliable experimental data for the permeability of silane. Last but not least, future extension of this work to the non-dilute limit may apply to the recovery of silane from

  18. Analysis of Gas Membrane Ultra-High Purification of Small Quantities of Mono-Isotopic Silane

    Energy Technology Data Exchange (ETDEWEB)

    de Almeida, Valmor F [ORNL; Hart, Kevin J [ORNL

    2016-09-01

    A small quantity of high-value, crude, mono-isotopic silane is a prospective gas for a small-scale, high-recovery, ultra-high membrane purification process. This is an unusual application of gas membrane separation for which we provide a comprehensive analysis of a simple purification model. The goal is to develop direct analytic expressions for estimating the feasibility and efficiency of the method, and guide process design; this is only possible for binary mixtures of silane in the dilute limit which is a somewhat realistic case. Among the common impurities in crude silane, methane poses a special membrane separation challenge since it is chemically similar to silane. Other potential problematic surprises are: ethylene, diborane and ethane (in this order). Nevertheless, we demonstrate, theoretically, that a carefully designed membrane system may be able to purify mono-isotopic, crude silane to electronics-grade level in a reasonable amount of time and expenses. We advocate a combination of membrane materials that preferentially reject heavy impurities based on mobility selectivity, and light impurities based on solubility selectivity. We provide estimates for the purification of significant contaminants of interest. To improve the separation selectivity, it is advantageous to use a permeate chamber under vacuum, however this also requires greater control of in-leakage of impurities in the system. In this study, we suggest cellulose acetate and polydimethylsiloxane as examples of membrane materials on the basis of limited permeability data found in the open literature. We provide estimates on the membrane area needed and priming volume of the cell enclosure for fabrication purposes when using the suggested membrane materials. These estimates are largely theoretical in view of the absence of reliable experimental data for the permeability of silane. Last but not least, future extension of this work to the non-dilute limit may apply to the recovery of silane from

  19. E. P. R. spectroscopic study of nitroxide mono- and bi-radicals

    International Nuclear Information System (INIS)

    A nitroxide is a molecule containing the group N-O where the oxygen atom made only one bond instead of the usual two. The main advantage of these radicals is their exceptional stability; this allows the study of well defined chemical structures while varying at will the experimental conditions. Studies by electron paramagnetic resonance of nitroxide mono-radicals have given the principal directions and the principal values of the electron-nitrogen nucleus hyperfine tensor and of the anisotropic g-factor tensor. The results were then related to the electronic structure of radicals. An understanding was obtained of the influence of the solvent on the principal values of the tensors, and the marked differences observed in the broadening of hyperfine lines when the medium become viscous. In the nitroxide biradicals, the hyperfine spectra depends not only on the magnetic interactions relative to each monomer, but also on the magnitude of the exchange interaction between the singlet and the triplet states of the dimer; the biradicals studied here are the first organic compounds which show clearly the influence of this exchange on the hyperfine structure. The two unpaired electrons also interact by a magnetic dipolar interaction: in the intermediate case, this can be used to derive the sign of the exchange interaction if the bi-radical is studied in a liquid crystal. Just as for mono-radicals, the hyperfine spectra of bi-radicals show selective broadening in viscous media, which is caused by an overall motional modulation of the anisotropic tensors. This gives another way to determine the sign of the exchange interaction. (author)

  20. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

    Energy Technology Data Exchange (ETDEWEB)

    Craig, Zelieann R., E-mail: zelieann@illinois.edu; Hannon, Patrick R., E-mail: phannon2@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2013-11-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P{sub 4}) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P{sub 4}, androstenedione (A), testosterone (T), estrone (E{sub 1}), and 17β-estradiol (E{sub 2}) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E{sub 2}. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P{sub 4}, A, T, and E{sub 1} that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis

  1. MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate

    Directory of Open Access Journals (Sweden)

    Erich K. Odermatt

    2012-01-01

    Full Text Available A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strength in vivo and is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ has no residual strength in vivo after 12 weeks. In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication.

  2. A comparative study of Mono Mac 6 cells, isolated mononuclear cells and Limulus amoebocyte lysate assay in pyrogen testing

    DEFF Research Database (Denmark)

    Moesby, Lise; Jensen, S; Hansen, E W;

    1999-01-01

    Pyrogen induced secretion of interleukin 6 (IL-6) in Mono Mac 6 (MM6) cells was measured. The ability of the MM6 cell culture to detect pyrogens was compared to the Limulus amoebocyte lysate (LAL) test and isolated mononuclear cells (MNC). The detection limit of MM6 for lipopolysaccharide (LPS...

  3. Efficient mono-acylation of fructose by lipase-catalyzed esterification in ionic liquid co-solvents.

    Science.gov (United States)

    Li, Lu; Ji, Fangling; Wang, Jingyun; Jiang, Bo; Li, Yachen; Bao, Yongming

    2015-10-30

    Fructose monoesters are eco-friendly nonionic surfactants in various applications. Selective preparation of mono-acylated fructose is challenging due to the multiple hydroxyl sites available for acylation both chemically and enzymatically. Ionic liquids (ILs) have profound impacts not only on the reaction media but also on the catalytic properties of enzymes in the acylation process. In this study, utilizing an IL co-solvent system, selective synthesis of mono-acylated fructose with lauric acid catalyzed by immobilized Candida antarctica lipase B (CALB) was investigated. The imidazolium-based ILs selected as co-solvents with 2-methyl-2-butanol (2M2B) markedly improved the ratios of monolauroyl fructose in the presence of 60% [BMIM][TfO] (v/v) and 20% [BMIM][BF4] (v/v), in which the mono-acylated fructose was 85% and 78% respectively. Based on a Ping-Pong Bi-Bi model, a kinetic equation was fitted, by which the kinetic parameters revealed that the affinity between fructose and acyl-enzyme intermediate was enhanced. The inhibition effect of fructose on free enzyme was weakened in the presence of IL co-solvents. The conformation of CALB binding substrates also changed in the co-solvent system as demonstrated by Fourier transform infrared spectra. These results demonstrated that the variation of CALB kinetic characteristics was a crucial factor for the selectivity of mono-acylation in ILs/2M2B co-solvents. PMID:26343327

  4. Mixed mono- and multilayers of poly(isocyanide)s with non-linear optically active side chains

    NARCIS (Netherlands)

    Teerenstra, M.N.; Hagting, J.G.; Oostergetel, G.T.; Schouten, A.J.; Devillers, M.A.C.; Nolte, R.J.M.

    1994-01-01

    The properties and structure of Langmuir-Blodgett mono- and multilayers of several poly(isocyanide)s with non-linear optically active side-chains were studied. These polymers formed very rigid layers or layers which appeared to be unstable. To circumvent this problem they were mixed with other poly(

  5. On Hydrogen Bonding in the Intramolecularly Chelated Taitomers of Enolic Malondialdehyde and its Mono- and Dithio-Analogues

    DEFF Research Database (Denmark)

    Carlsen, Lars; Duus, Fritz

    1980-01-01

    The intramolecular hydrogen bondings in enolic malondialdehyde and it mono- and dithio-analogues have been evaluated by a semiempricial SCF–MO–CNDO method. The calculations predict that the hydrogen bonds play an important part in the stabilities of malondialdehyde and monothiomalondialdehyde, wh......, whereas dithiomalondialdehyde hardly exists as a hydrogen-chelated tautomeric form....

  6. α1/α2-Adrenoceptor agonist selectivity of mono- and dihydroxy-2-N,N-di-n-propylaminotetralins

    NARCIS (Netherlands)

    Timmermans, P.B.M.W.M.; Mathy, M.J.; Wilffert, B.

    1984-01-01

    The pressor activities and the identity of the postjunctonal α-adrenoceptors involved were determined for a series of congeneric mono- and dihydroxy-substituted 2-N,N-di-n-propylaminotetralins and N,N-di-n-propyldopamine (DPDA) following i.v. administration to pithed normotensive rats. The affinity

  7. A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

    NARCIS (Netherlands)

    Cankar, K.; Houwelingen, van A.M.M.L.; Bosch, H.J.; Sonke, Th.; Bouwmeester, H.J.; Beekwilder, M.J.

    2011-01-01

    Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene syntha

  8. Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome as compared to germ-free mice

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper;

    of colonizing bacteria. In this study the effect of the Lactobacillus acidophilus NCFM strain was investigated by comparing the metabolome of mono-colonized and germ-free mice in several compartments. By liquid-chromatography coupled to mass spectrometry, we were able to show that the metabolome differed...

  9. Ammonia and hydrogen sulfide concentration and emission patterns for mono-slope beef cattle facilities in the Northern Great Plains

    Science.gov (United States)

    Mono-slope buildings are one type of roofed and confined cattle feeding facility that is becoming increasingly popular in the Northern Great Plains. In response to questions and concerns about the barn environment and air quality regulations, the objectives of this study were to determine gas concen...

  10. 21 CFR 582.4521 - Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4521 Section 582.4521 Food and... Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat-forming... oils, or edible fat-forming fatty acids. (b) Conditions of use. This substance is generally...

  11. Separation of middle rare earths by solvent extraction using 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester as an extractant

    Institute of Scientific and Technical Information of China (English)

    Danilo; Fontana; Loris; Pietrelli

    2009-01-01

    The extraction of the trivalent middle rare earths from chloride media by kerosene solutions of 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester as an extractant was studied. The separation factors between the elements using solution simulating wastes from NiMH spent batteries have been evaluated: the order of the extractive ability of extractant can be confirmed in ThGdEuSm.

  12. Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal

    NARCIS (Netherlands)

    Peters, A.K.; Leonards, P.E.G.; Zhao, B.; Bergman, A.; Denison, M.S.; Berg, van den M.

    2006-01-01

    The TEF system for dioxin-like compounds has included assignment of TEF values for mono-ortho polychlorinated biphenyls (MO-PCBs). Small traces of aryl hydrocarbon receptor (AhR)-active impurities could result in artifactually higher relative potency (REP) values. MO-PCBs -105, -118, -156, and -167

  13. Chemical Composition of Magnetic Minerals in the Sedimentary Interval Containing the Mono Lake Excursion from Summer Lake, Oregon, U.S.A

    Science.gov (United States)

    Horton, R. A.; Lopez, J.; Thompson, G. R.; Soto, C.; Herrera, I. S.; Sevier, K. L.; Negrini, R. M.

    2011-12-01

    Oriented piston cores were taken from Summer Lake for the purpose of obtaining a high-resolution paleomagnetic record of the Mono Lake Excursion. McCuan (2011) reported that the main magnetic carrier mineral is consistent throughout the cores and is composed principally of pseudo-single domain titanomagnetite. This result is based on XRD scans of magnetic mineral separates and modified Day plots of bulk sediment hysteresis parameters. In addition, small amounts of maghemite, hematite, and ilmenite were identified using reflected light microscopy though these did not show up in the XRD patterns or bulk hysteresis analyses. In contrast to the above results, preliminary SIRM unmixing results suggest the presence of at least three different significant magnetic carriers with moderately low coercivities. To test the unmixing results, magnetic separates were obtained from core samples and prepared into polished sections for analysis using the SEM-EDS at CSUB. Grains in excess of 10 um were randomly analyzed (N = 646). The vast majority of grains were titanomagnetites with atomic Fe:Ti ranging from 7.5:2.5 to 8.5:1.5, but there are also small amounts of ulvospinel, magnetite, and occasionally Fe-rich chromite, and most grains contain small amounts of Mg, Al, and Cr. Ternary plots of Fe-Ti-Cr show multiple wide but similar compositional ranges at all depths. These compositional data generally support the SIRM unmixing results suggesting three or so families of magnetic minerals.

  14. Análisis retrospectivo de las enfermedades parasitarias del mono ardilla (Saimiri sciureus en dos condiciones ex situ en el noroccidente de los Andes suramericanos

    Directory of Open Access Journals (Sweden)

    Laura Catalina Botero C.

    2011-12-01

    Full Text Available El mono ardilla (Cebidae: Saimiri sciureus es una especie de primate neotropical. La mayor susceptibilidad a la presencia de parásitos en estos primates se puede deber a las condiciones ex situ a las que se encuentran sometidos, en donde se exponen a diferentes factores ambientales y de manejo. A partir de las historias clínicas de una población de 94 Saimiri sciureus del Parque Zoológico Jaime Duque (PZJD y de la Unidad de Rescate y Rehabilitación de Animales Silvestres (Urras, instituciones ubicadas al noroccidente de los Andes suramericanos, se determinó la presencia de los parásitos diagnosticados en estas dos condiciones (exhibición y rehabilitación, respectivamente, estableciendo la posible asociación con la edad, el sexo, la sintomatología y los medicamentos. Se utilizaron histogramas y prueba de chi cuadrado para definir las diferencias de parásitos en estos dos lugares y poder determinar la mayor frecuencia presente en Saimiri sciureus. Por otro lado, el limitado conocimiento y los estudios parasitológicos de estos primates delimitan la gestión pública y dificultan el establecimiento de posibles zoonosis.

  15. Hot-electron real-space transfer and longitudinal transport in dual AlGaN/AlN/{AlGaN/GaN} channels

    Science.gov (United States)

    Šermukšnis, E.; Liberis, J.; Matulionis, A.; Avrutin, V.; Ferreyra, R.; Özgür, Ü.; Morkoç, H.

    2015-03-01

    Real-space transfer of hot electrons is studied in dual-channel GaN-based heterostructure operated at or near plasmon-optical phonon resonance in order to attain a high electron drift velocity at high current densities. For this study, pulsed electric field is applied in the channel plane of a nominally undoped Al0.3Ga0.7N/AlN/{Al0.15Ga0.85N/GaN} structure with a composite channel of Al0.15Ga0.85N/GaN, where the electrons with a sheet density of 1.4 × 1013 cm-2, estimated from the Hall effect measurements, are confined. The equilibrium electrons are situated predominantly in the Al0.15Ga0.85N layer as confirmed by capacitance-voltage experiment and Schrödinger-Poisson modelling. The main peak of the electron density per unit volume decreases as more electrons occupy the GaN layer at high electric fields. The associated decrease in the plasma frequency induces the plasmon-assisted decay of non-equilibrium optical phonons (hot phonons) confirmed by the decrease in the measured hot-phonon lifetime from 0.95 ps at low electric fields down below 200 fs at fields of E \\gt 4 kV cm-1 as the plasmon-optical phonon resonance is approached. The onset of real-space transfer is resolved from microwave noise measurements: this source of noise dominates for E \\gt 8 kV cm-1. In this range of fields, the longitudinal current exceeds the values measured for a mono channel reference Al0.3Ga0.7N/AlN/GaN structure. The results are explained in terms of the ultrafast decay of hot phonons and reduced alloy scattering caused by the real-space transfer in the composite channel.

  16. Scenario earthquake hazards for the Long Valley Caldera-Mono Lake area, east-central California

    Science.gov (United States)

    Chen, Rui; Branum, David M.; Wills, Chris J.; Hill, David P.

    2014-01-01

    As part of the U.S. Geological Survey’s (USGS) multi-hazards project in the Long Valley Caldera-Mono Lake area, the California Geological Survey (CGS) developed several earthquake scenarios and evaluated potential seismic hazards, including ground shaking, surface fault rupture, liquefaction, and landslide hazards associated with these earthquake scenarios. The results of these analyses can be useful in estimating the extent of potential damage and economic losses because of potential earthquakes and in preparing emergency response plans. The Long Valley Caldera-Mono Lake area has numerous active faults. Five of these faults or fault zones are considered capable of producing magnitude ≥6.7 earthquakes according to the Uniform California Earthquake Rupture Forecast, Version 2 (UCERF 2) developed by the 2007 Working Group of California Earthquake Probabilities (WGCEP) and the USGS National Seismic Hazard Mapping (NSHM) Program. These five faults are the Fish Slough, Hartley Springs, Hilton Creek, Mono Lake, and Round Valley Faults. CGS developed earthquake scenarios for these five faults in the study area and for the White Mountains Fault to the east of the study area. Earthquake scenarios are intended to depict the potential consequences of significant earthquakes. They are not necessarily the largest or most damaging earthquakes possible. Earthquake scenarios are both large enough and likely enough that emergency planners should consider them in regional emergency response plans. Earthquake scenarios presented here are based on fault geometry and activity data developed by the WGCEP, and are consistent with the 2008 Update of the United States National Seismic Hazard Maps (NSHM).For the Hilton Creek Fault, two alternative scenarios were developed in addition to the NSHM scenario to account for different opinions in how far north the fault extends into the Long Valley Caldera. For each scenario, ground motions were calculated using the current standard practice

  17. Amyotrophic Lateral Sclerosis (ALS)

    Science.gov (United States)

    ... benefit of 16 months before onset of severe respiratory failure. Other treatments are designed to relieve symptoms and ... of ALS. Most people with ALS die from respiratory failure, usually within 3 to 5 years from the ...

  18. Impacto del ejercicio de fuerza muscular en la prevención secundaria de la obesidad infantil: intervención al interior del sistema escolar

    Directory of Open Access Journals (Sweden)

    Fabián Vásquez

    2013-04-01

    Full Text Available Introducción: El ejercicio físico es una importante herramienta terapéutica para prevenir y tratar la obesidad y disminuir las alteraciones metabólicas asociadas al desarrollo de las enfermedades crónicas no transmisibles. Objetivo: Evaluar el impacto de una intervención al interior del sistema escolar, que incluye el ejercicio de fuerza muscular, educación alimentaria y apoyo psicológico en escolares obesos. Métodos: Se trabajó con 120 escolares obesos, entre 8 y 13 años, reclutados en 3 colegios. El Grupo 1 (n = 60, fueron intervenidos simultáneamente con ejercicio físico, educación alimentaria y apoyo psicológico durante 3 meses. El Grupo 2 (n = 60, durante el mismo período, recibió sólo la intervención educativa y el apoyo psicológico, siendo intervenido con ejercicio entre los 3 y los 6 meses. Se evaluó IMC, perímetro de cintura, grasa corporal, síndrome metabólico y factores de riesgo cardiovasculares. Resultados: A los 3 meses, hubo diferencias significativas entre ambos grupos en la variación del zIMC, circunferencia cintura, grasa corporal, síndrome metabólico, obesidad abdominal, hipertrigliceridemia e hiperglicemia de ayuno. En el grupo 1, estos parámetros disminuyeron y aumentaron, en el grupo 2. Entre los 3-6 meses, en el grupo 2, hubo una disminución significativa en la obesidad abdominal, presión arterial elevada e hipertrigliceridemia, en tanto en el grupo 1, aumento significativo de la presión arterial elevada sin variaciones en los otros factores de riesgo cardiovasculares. Conclusiones: Se demostró el impacto positivo del ejercicio físico de fuerza muscular en la reducción de la grasa corporal, del síndrome metabólico y de los factores de riesgo cardiovasculares. Este trabajo refuerza el uso del ejercicio como tratamiento de la obesidad y de sus comorbilidades en escolares.

  19. Preliminary results of polarization signatures for glacial moraines in the Mono Basin, Eastern Sierra Nevada

    Science.gov (United States)

    Forster, Richard R.; Fox, Andrew N.; Isacks, Bryan

    1992-01-01

    The valleys of the Mono Basin contain several sets of lateral and terminal moraines representing multiple stages of glaciation. The semi-arid climate with slow weathering rates preserved sequences of nested younger moraines within older ones. There is a well established relative chronology and recently exposure dating provided a new set of numerical dates. The moraines span the late Wisconsin (11-25 ka) to the Illinoian (130-190 ka) glaciations. The Mono Basin area was used as a 'calibration site' to establish remote dating techniques for eventual transfer to the more inaccessible but geomorphically and climatically similar moraines of the South American Andes Mountains. Planned polarimetric synthetic aperture radar (SAR) imagery acquired by JPL AIRSAR (South American Campaign) and SIR-C (Andes super-site) are analyzed to establish chronologies of previously undated moraine sequences in a study of Pleistocene climatic change in the Southern Hemisphere. The dry climate and sparse vegetation is also favorable for correlation of ground surface roughness with radar polarization signature. The slow weathering processes acting over thousands of years reduce the size, frequency, and angularity of surface boulders while increasing soil development on the moraines. Field observations based on this hypothesis result in relative ages consistent with those inferred from nested position within the valley. Younger moraines, therefore, will appear rougher than the older smoother moraines at scales measurable at AIRSAR wavelengths. Previously documented effects of ground surface roughness on polarization signatures suggest that analysis of moraine polarization signatures can be useful for relative dating. The technique may be extended to predict numerical ages. The data set reported were acquired on 8 Sep. 1989 with the JPL Airborne SAR (AIRSAR) collecting polarimetric imagery at C- (5.6 cm), L- (24 cm), and P-band (68 cm) with a flight-line parallel to the strike of the mountains

  20. Dwelling and Travel: Octavio Paz and El mono gramático

    Directory of Open Access Journals (Sweden)

    Susan Briante

    2008-01-01

    Full Text Available A partir du prétexte de ces quelques mots : « le mieux serait de suivre le chemin de Galta », Octavio Paz commence une de ses œuvres les plus fascinantes et complexes : « Le singe grammairien ». Publié originairement en français, en 1972, ce texte apparaît comme un récit de voyage du séjour de l’auteur en Inde. Cependant, à travers ses descriptions méticuleuses des paysages de l’Inde et une astucieuse narration à la première personne, le texte serpente tel un sentier peu fréquenté à travers des explorations métapoétiques. Cet article replace « Le singe grammairien » dans la tradition de différents textes surréalistes - dont « Souvenir du Mexique » d’André Breton - qui explorent la confrontation avec l’Autre dans le contexte d’une révélation spirituelle. En situant cette investigation langagière dans le cadre de la contemplation d’un paysage exotique, Paz réalise ce que le critique James Clifford aurait appelé « une ethnographie moderne des conjonctures ».With little more pretext than the words : “lo mejor será escoger el camino de Galta,” Octavio Paz begins one of his most compelling and perplexing works : "El mono gramático." Published originally in French in 1972, the text appears to be a travelogue from Paz’s time in India. But with its meticulous descriptions of Indian landscapes and an astute first person narration, the text winds like a rarely traveled path through metapoetic explorations. This paper considers "El mono gramático" within the tradition of several Surrealist texts-Andre Breton’s “Souvenir du Mexique,” among them-that narrate the confrontation with the Other in the context of a spiritual revelation. By situating this inquisition of language within the contemplation of an exotic landscape, Paz achieves what the cultural critic James Clifford would call “a modern ethnography of conjunctures.”

  1. The Mono Arch, eastern Sierra region, California: Dynamic topography associated with upper-mantle upwelling?

    Science.gov (United States)

    Jayko, A.S.

    2009-01-01

    A broad, topographic flexure localized east of and over the central and southern Sierra Nevada, herein named the Mono Arch, apparently represents crustal response to lithospheric and/or upper-mantle processes, probably dominated by mantle upwelling within the continental interior associated Pacific-North American plate-boundary deformation. This zone of flexure is identified through comparison between the topographic characteristics of the active Cascade volcanic arc and backarc regions with the analogous former arc and backarc in the Sierra Nevada and eastern Sierra Nevada. Serial topographic profiles measured normal to the modern Cascade backarc reveal an accordance of topographic lows defined by valley floors with an average minimum elevation of ???1400-1500m for over 175km to the southeast. Although the accordance drops in elevation slightly to the south, the modern Cascade backarc region is remarkably level, and is characterized by relief up to ???750m above this baseline elevation. By contrast, serial topographic profiles over the former arc and backarc transitions of the eastern Sierra region exhibit a regional anticlinal warping defined by accordant valley floors and by a late Miocene-early Pliocene erosion surface and associated deposits. The amplitude of this flexure above regionally flat baseline elevations to the east varies spatially along the length of the former Sierran arc, with a maximum of ???1000m centred over the Bridgeport Basin. The total zone of flexure is approximately 350km long N-S and 100km wide E-W, and extends from Indian Wells Valley in the south to the Sonora Pass region in the north. Previous geophysical, petrologic, and geodetic studies suggest that the Mono Arch overlies a zone of active mantle upwelling. This region also represents a zone crustal weakness formerly exploited by the middle-to-late Miocene arc and is presently the locus of seismic and volcanic activities. This seismic zone, which lies east of the Sierra Nevada block

  2. Photoinduced Electron Transfer in Host-Guest Complexes of 2-Naphthyl-(OCH2CH2)n-adamantanamines with Mono-6-O-p-nitrobenzoyl-β-cyclodextrin and Mono-6-O-m-nitrobenzoyl-β-cyclodextrin

    Institute of Scientific and Technical Information of China (English)

    吴其华; 朱满洲; 魏苏军; 刘磊; 郭庆祥

    2005-01-01

    A number of naphthalene donor compounds that possess an adamantanamine binding moiety and an (OCH2CH2)n (nn1, 2, 3, 4, 6, 8) spacer were synthesized. The fluorescence quenching between these donor substrates and mono-6-O-p-nitrobenzoyl-β-cyclodextrin (pNBCD) and mono-6-O-m-nitrobenzoyl-β-cyclodextrin(mNBCD) was studied in detail. It was found that very efficient fluorescence quenching could occur in these supramolecular systems. This quenching was attributed to the photoinduced electron transfer inside the supramolecular assembly between the naphthalene donors and cyclodextrin acceptors. Detailed Stern-Volmer constants were measured and they were partitioned into dynamic Stern-Volmer quenching constants and static binding constants. It was demonstrated that the binding constants between all the naphthalene compounds and cyclodextrins are the same as they possess the same binding site, i.e., adamantanamine.

  3. Mixtures of mono-, di- and tri-glycerides as energy supplements to broilers’ diets

    Directory of Open Access Journals (Sweden)

    Sara Minieri

    2010-01-01

    Full Text Available Mixtures of mono-, di- and tri-glycerides from olive oil (MDT were added to: palm oil (PO, olive oil (OO, soybean oil (SO, free fatty acids from palm oil (PFA, free fatty acids from olive oil (OFA. The compound mixtures were used as energy supplements in the diets of broiler chickens in comparison with plain SO and plain animal fat (AF. Two hundred and ten birds were randomly allotted to 7 dietary treatments with the diverse oil sources: 6 birds per cage, 5 cages per treatment. The effects of the treatments on growth rates, feed/gain ratios and acidic composition of abdominal fat of hybrid Ross 308 female chickens were studied. The animals were slaughtered at the end of the trial, at day 35. The breast meat quality was then evaluated by a panel of 15 trained members and analysed for shelf life duration. The AF treat- ment gave the highest weight gain, but only in the first week. MDT + OO (50/50 resulted the best combination, with slight, non significant, better performances and a decidedly better quality in terms of acidic composition of abdominal fat, taste and juiciness of breast meat and shelf life.

  4. Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties

    Directory of Open Access Journals (Sweden)

    Eva Vavříková

    2016-06-01

    Full Text Available A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica, which accepted C5- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C2, malonic (C3, succinic (C4 and maleic (C4 acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin–Ciocalteau reagent (FCR and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl than isoquercitrin; ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid radical-scavenging activity was comparable. Dodecanoate and palmitate were the least active in FCR and ABTS scavenging; dodecanoate and hemiglutarate were the strongest DPPH scavengers. In contrast, most derivatives were much better inhibitors of microsomal lipoperoxidation than isoquercitrin; butyrate and hexanoate were the most efficient. Anti-lipoperoxidant activity of monocarboxylic derivatives, except acetates, decreased with increasing aliphatic chain. The opposite trend was noted for dicarboxylic acid hemiesters, isoquercitrin hemidodecanedioate being the most active. Overall, IQ butyrate, hexanoate and hemidodecanedioate are the most promising candidates for further studies.

  5. Inhibition of human platelet phospholipase A/sub 2/ by mono(2-ethylhexyl)phthalate

    Energy Technology Data Exchange (ETDEWEB)

    Labow, R.S.; Meek, E.; Adams, G.A.; Rock, G.

    1988-06-01

    There is evidence that the carcinogenic and teratogenic effects attributed to the plasticizer di(2-ethylhexyl)phthalate (DEHP) are due to its major metabolite mono(2-ethylhexyl)phthalate (MEHP). MEHP is also formed ex vivo by a plasma enzyme in blood products stored in polyvinyl chloride (PVC) DEHP plastic containers. People who receive large amounts of blood products, such as hemophiliacs or patients undergoing hemodialysis, cardiopulmonary bypass, or massive transfusion, are exposed to significant levels of plasticizer. In this study, the platelet was used to show that MEHP inhibits phospholipase A/sub 2/ (PLA/sub 2/), one of the enzymes important in the release of arachidonic acid from membrane phospholipids. PLA/sub 2/ was measured by the liberation of /sup 14/C-arachidonic acid from 1-stearoyl-2-(1-/sup 14/C)arachidonyl-L-3-phosphatidylcholine. MEHP inhibits PLA/sub 2/ activity noncompetitively in intact human platelets and lysates with a K/sub i/ of 3.7 x 10/sup -4/ M. DEHP does not inhibit PLA/sub 2/ in whole platelets. Inhibition of PLA/sub 2/ by MEHP occurs at only three times the circulating level of MEHP measured in neonates undergoing exchange transfusion and 20-fold the levels experienced by patients during cardiopulmonary bypass. Therefore, infants and adult patients with multisystem failure who accumulate MEHP in their blood may be at risk for decreased platelet function.

  6. Mono- and Dinuclear Macrocyclic Calcium Complexes as Platforms for Mixed-Metal Complexes and Clusters.

    Science.gov (United States)

    Connolly, Emma A; Leeland, James W; Love, Jason B

    2016-01-19

    Mono- and dinuclear calcium complexes of the Schiff-base macrocycles H4L have been prepared and characterized spectroscopically and crystallographically. In the formation of Ca(THF)2(H2L(1)), Ca2(THF)2(μ-THF)(L(1)), and Ca2(THF)4(L(2)), the ligand framework adopts a bowl-shaped conformation instead of the conventional wedge, Pacman-shaped structure as seen with the anthracenyl-hinged complex Ca2(py)5(L(3)). The mononuclear calcium complex Ca(THF)2(H2L(1)) reacts with various equivalents of LiN(SiMe3)2 to form calcium/alkali metal clusters and dinuclear transition metal complexes when reacted subsequently with transition metal salts. The dinuclear calcium complex Ca2(THF)2(μ-THF)(L(1)), when reacted with various equivalents of NaOH, is shown to act as a platform for the formation of calcium/alkali metal hydroxide clusters, displaying alternate wedged and bowl-shaped conformations.

  7. Synthesis of mono and multidomain YIG particles by chemical coprecipitation or ceramic procedure

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Garcia, L. [Departamento de Materiales Nanoestructurados, Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN), Principado de Asturias - Consejo superior de Investigaciones Cientificas (CSIC) - Universidad de Oviedo - UO, Parque Tecnologico de Asturias, 33428 Llanera, Asturias (Spain); Suarez, M., E-mail: m.suarez@cinn.e [Departamento de Materiales Nanoestructurados, Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN), Principado de Asturias - Consejo superior de Investigaciones Cientificas (CSIC) - Universidad de Oviedo - UO, Parque Tecnologico de Asturias, 33428 Llanera, Asturias (Spain); Menendez, J.L. [Departamento de Materiales Nanoestructurados, Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN), Principado de Asturias - Consejo superior de Investigaciones Cientificas (CSIC) - Universidad de Oviedo -UO, Parque Tecnologico de Asturias, 33428 Llanera, Asturias (Spain)

    2010-04-09

    Yttrium iron garnet powders have been synthesized by chemical coprecipitation using two different precursors, nitrates and chlorides, and by an oxides mixture route. It is shown that depending on the precursors and synthesis conditions used pure yttrium iron garnet powders can be obtained with a mono or multidomain magnetic behaviour. The yttrium iron garnet crystalline structure, as studied by Raman spectroscopy, was already formed after calcination at temperatures as low as 800 {sup o}C when the nitrate precursors were used. However, calcination temperatures of up to 1100 {sup o}C were required to obtain yttrium iron garnet powders when the precursors were chlorides or when the oxides mixture route was chosen. The saturation magnetization of the powders correlates well with the structural characterization: when nitrate precursors were used, the saturation magnetization was already close to the bulk value, 26.8 emu/cm{sup 3}, after calcination at 800 {sup o}C. However, the saturation magnetization of the powders obtained by the chlorides and oxides mixture routes was close to zero up to calcination temperatures of 1100 {sup o}C. Finally, both the chlorides and the oxides mixture routes yield multidomain micron sized yttrium iron garnet powders, whereas the nitrates route led to monodomain submicron sized powders.

  8. Inkjet Printing Based Mono-layered Photonic Crystal Patterning for Anti-counterfeiting Structural Colors

    Science.gov (United States)

    Nam, Hyunmoon; Song, Kyungjun; Ha, Dogyeong; Kim, Taesung

    2016-08-01

    Photonic crystal structures can be created to manipulate electromagnetic waves so that many studies have focused on designing photonic band-gaps for various applications including sensors, LEDs, lasers, and optical fibers. Here, we show that mono-layered, self-assembled photonic crystals (SAPCs) fabricated by using an inkjet printer exhibit extremely weak structural colors and multiple colorful holograms so that they can be utilized in anti-counterfeit measures. We demonstrate that SAPC patterns on a white background are covert under daylight, such that pattern detection can be avoided, but they become overt in a simple manner under strong illumination with smartphone flash light and/or on a black background, showing remarkable potential for anti-counterfeit techniques. Besides, we demonstrate that SAPCs yield different RGB histograms that depend on viewing angles and pattern densities, thus enhancing their cryptographic capabilities. Hence, the structural colorations designed by inkjet printers would not only produce optical holograms for the simple authentication of many items and products but also enable a high-secure anti-counterfeit technique.

  9. Proposal for a parametric conceptual CAD model of a mono-modular inertial fusion reactor

    International Nuclear Information System (INIS)

    The present work tries to solve the problem of realizing a parametric conceptual CAD model of a modular reactor for future inertial fusion power plants. The choice of a modular structure seems to be a good solution for efficiency and economic requirements. On the other hand, the realization of a parametric-variational CAD model is very useful to optimize nuclear and mechanical parameters and to permit the shift from the conceptual to the final model. First, geometric solutions for a modular reactor are analysed; the most interesting is that of a 20-face regular polyhedron (icosahedron). The subdivision of each face into six equal triangles consents to obtain a mono-modular reactor with 120 modules (called 'ICO120'). This solution should be easy, efficient and cheap. Secondly, the work proposes a conceptual CAD model of the ICO120 reactor in which special attention is put on the parametrization. Starting from such parametric model it will be possible to develop and optimize icosahedral reactors with different features, sizes and performances

  10. The Santa Cruz - Tarija Province of Central South America: Los Monos - Machareti(!) Petroleum System

    Science.gov (United States)

    Lindquist, Sandra J.

    1999-01-01

    The Los Monos - Machareti(!) total petroleum system is in the Santa Cruz - Tarija Province of Bolivia, Argentina and Paraguay. Province history is that of a Paleozoic, intracratonic, siliciclastic rift basin that evolved into a Miocene (Andean) foreland fold and thrust belt. Existing fields are typified by alternating reservoir and seal rocks in post-Ordovician sandstones and shales on anticlines. Thick Devonian and Silurian shale source rocks, depositionally and erosionally confined to this province, at a minimum have generated 4.1 BBOE known ultimate recoverable reserves (as of 1995, 77% gas, 15% condensate, 8% oil) into dominantly Carboniferous reservoirs with average 20% porosity and 156 md permeability. Major detachment surfaces within the source rocks contributed to the thin-skinned and laterally continuous nature of the deformation. Tertiary foreland burial adequate for significant source maturation coincided with the formation of compressional traps. Further hydrocarbon discovery in the fold and thrust belt is expected. In the foreland basin, higher thermal gradients and variable burial history - combined with the presence of unconformity and onlap wedges - create potential there for stratigraphic traps and pre-Andean, block-fault and forced-fold traps.

  11. Mono or 3D video production for scientific dissemination of nuclear energy applications

    International Nuclear Information System (INIS)

    This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

  12. A mono-dimensional nuclear fuel performance analysis code, PUMA, development from a coupled approach

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, J. S.; Lee, B. O.; Lee, C. B. [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseong, Daejeon, 305-353 (Korea, Republic of); Yacout, A. M. [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)

    2013-07-01

    Multidimensional-multi-physical phenomena in nuclear fuels are treated as a set of mono-dimensional-coupled problems which encompass heat, displacement, fuel constituent redistribution, and fission gas release. Rather than uncoupling these coupled equations as in conventional fuel performance analysis codes, efforts are put into to obtain fully coupled solutions by relying on the recent advances of numerical analysis. Through this approach, a new SFR metal fuel performance analysis code, called PUMA (Performance of Uranium Metal fuel rod Analysis code) is under development. Although coupling between temperature and fuel constituent was made easily, the coupling between the mechanical equilibrium equation and a set of stiff kinetics equations for fission gas release is accomplished by introducing one-level Newton scheme through backward differentiation formula. Displacement equations from 1D finite element formulation of the mechanical equilibrium equation are solved simultaneously with stress equation, creep equation, swelling equation, and FGR equations. Calculations was made successfully such that the swelling and the hydrostatic pressure are interrelated each other. (authors)

  13. A mono-dimensional nuclear fuel performance analysis code, PUMA, development from a coupled approach

    International Nuclear Information System (INIS)

    Multidimensional-multi-physical phenomena in nuclear fuels are treated as a set of mono-dimensional-coupled problems which encompass heat, displacement, fuel constituent redistribution, and fission gas release. Rather than uncoupling these coupled equations as in conventional fuel performance analysis codes, efforts are put into to obtain fully coupled solutions by relying on the recent advances of numerical analysis. Through this approach, a new SFR metal fuel performance analysis code, called PUMA (Performance of Uranium Metal fuel rod Analysis code) is under development. Although coupling between temperature and fuel constituent was made easily, the coupling between the mechanical equilibrium equation and a set of stiff kinetics equations for fission gas release is accomplished by introducing one-level Newton scheme through backward differentiation formula. Displacement equations from 1D finite element formulation of the mechanical equilibrium equation are solved simultaneously with stress equation, creep equation, swelling equation, and FGR equations. Calculations was made successfully such that the swelling and the hydrostatic pressure are interrelated each other. (authors)

  14. Lack of detectable DNA uptake by transformation of selected recipients in mono-associated rats

    Directory of Open Access Journals (Sweden)

    Jacobsen Bodil BL

    2010-03-01

    Full Text Available Abstract Background An important concern revealed in the public discussion of the use of genetically modified (GM plants for human consumption, is the potential transfer of DNA from these plants to bacteria present in the gastrointestinal tract. Especially, there is a concern that antibiotic resistance genes used for the construction of GM plants end up in pathogenic bacteria, eventually leading to untreatable disease. Findings Three different bacterial species (Escherichia coli, Bacillus subtilis, Streptococcus gordonii, all natural inhabitants of the food and intestinal tract environment were used as recipients for uptake of DNA. As source of DNA both plasmid and genomic DNA from GM plants were used in in vitro and in vivo transformation studies. Mono-associated rats, creating a worst-case scenario, did not give rise to any detectable transfer of DNA. Conclusion Although we were unable to detect any transformation events in our experiment, it cannot be ruled out that this could happen in the GI tract. However, since several steps are required before expression of plant-derived DNA in intestinal bacteria, we believe this is unlikely, and antibiotic resistance development in this environment is more in danger by the massive use of antibiotics than the consumption of GM food harbouring antibiotic resistance genes.

  15. Contribution of mono and polysaccharides to heterotrophic N2 fixation at the eastern Mediterranean coastline.

    Science.gov (United States)

    Rahav, E; Giannetto, M J; Bar-Zeev, E

    2016-01-01

    N2 fixation should be a critical process in the nitrogen-poor surface water of the eastern Mediterranean Sea. Despite favorable conditions, diazotroph abundance and N2 fixation rates remains low for reasons yet explained. The main goal of this study was to investigate the limiting nutrients for diazotrophy in this oligotrophic environment. Hence, we conducted dedicated bottle-microcosms with eastern Mediterranean Sea water that were supplemented with mono and polysaccharides as well as inorganic nitrogen and phosphorous. Our results indicate that the diazotrophic community expressing nifH was primarily represented by heterotrophic Proteobacteria. N2 fixation and heterotrophic bacterial activity increased up-to tenfold following two days of dark incubations, once seawater was supplemented with organic carbon substrate in the form of glucose (monosaccharides) or gum-xanthan (polysaccharide surrogate). Furthermore, our results point that carbon-rich polysaccharides, such as transparent exopolymer particles, enhance heterotrophic N2 fixation, by forming microenvironments of intense metabolic activity, high carbon: nitrogen ratio, and possibly low O2 levels. The conclusions of this study indicate that diazotrophs in the eastern Mediterranean coast are primarily limited by organic carbon substrates, as possibly in many other marine regions.

  16. An optimal design of a mono-stable vertical diamagnetic levitation based electromagnetic vibration energy harvester

    Science.gov (United States)

    Palagummi, S.; Yuan, F. G.

    2015-04-01

    A detailed analysis of a mono-stable vertical diamagnetic levitation (VDL) system for optimal vibration energy harvesting is presented. Initial studies showed that simple analytical techniques such as the dipole model and the image method provide useful guideline for understanding the potential of a diamagnetic levitation system, however, it is discussed here that the more accurate semi-analytical techniques such as the thin coil model and the discrete volume method are needed for quantitative optimization and design of the VDL system. With the semi-analytical techniques, the influence of the cylindrical geometry of the floating magnet, the lifting magnet and the diamagnetic plate are parametrically studied to assess their effects on the levitation gap, size of the system and the natural frequency. For efficient vibration energy harvesting using the VDL system, ways to mitigate eddy current damping and a coil geometry for transduction are critically discussed. With the optimized parameters, an experimental system is realized which showed a hardening type nonlinearity. The results show an overall efficiency of 1.54 percent, a root mean square (rms) power output of 1.72 μW when excited at a peak acceleration of 0.081 m/s2 and at a frequency of 2.1 Hz.

  17. Mono- and binuclear non-heme iron chemistry from a theoretical perspective.

    Science.gov (United States)

    Rokob, Tibor András; Chalupský, Jakub; Bím, Daniel; Andrikopoulos, Prokopis C; Srnec, Martin; Rulíšek, Lubomír

    2016-09-01

    In this minireview, we provide an account of the current state-of-the-art developments in the area of mono- and binuclear non-heme enzymes (NHFe and NHFe2) and the smaller NHFe(2) synthetic models, mostly from a theoretical and computational perspective. The sheer complexity, and at the same time the beauty, of the NHFe(2) world represents a challenge for experimental as well as theoretical methods. We emphasize that the concerted progress on both theoretical and experimental side is a conditio sine qua non for future understanding, exploration and utilization of the NHFe(2) systems. After briefly discussing the current challenges and advances in the computational methodology, we review the recent spectroscopic and computational studies of NHFe(2) enzymatic and inorganic systems and highlight the correlations between various experimental data (spectroscopic, kinetic, thermodynamic, electrochemical) and computations. Throughout, we attempt to keep in mind the most fascinating and attractive phenomenon in the NHFe(2) chemistry, which is the fact that despite the strong oxidative power of many reactive intermediates, the NHFe(2) enzymes perform catalysis with high selectivity. We conclude with our personal viewpoint and hope that further developments in quantum chemistry and especially in the field of multireference wave function methods are needed to have a solid theoretical basis for the NHFe(2) studies, mostly by providing benchmarking and calibration of the computationally efficient and easy-to-use DFT methods. PMID:27229513

  18. Sponge Phases and Nanoparticle Dispersions in Aqueous Mixtures of Mono- and Diglycerides.

    Science.gov (United States)

    Valldeperas, Maria; Wiśniewska, Małgorzata; Ram-On, Maor; Kesselman, Ellina; Danino, Dganit; Nylander, Tommy; Barauskas, Justas

    2016-08-30

    The lipid liquid crystalline sponge phase (L3) has the advantages that it is a nanoscopically bicontinuous bilayer network able to accommodate large amounts of water and it is easy to manipulate due to its fluidity. This paper reports on the detailed characterization of L3 phases with water channels large enough to encapsulate bioactive macromolecules such as proteins. The aqueous phase behavior of a novel lipid mixture system, consisting of diglycerol monooleate (DGMO), and a mixture of mono-, di- and triglycerides (Capmul GMO-50) was studied. In addition, sponge-like nanoparticles (NPs) stabilized by Polysorbate 80 (P80) were prepared based on the DGMO/GMO-50 system, and their structure was correlated with the phase behavior of the corresponding bulk system. These NPs were characterized by dynamic light scattering (DLS), cryo-transmission electron microscopy (Cryo-TEM) and small angle X-ray scattering (SAXS) to determine their size, shape, and inner structure as a function of the DGMO/GMO-50 ratio. In addition, the effect of P80 as stabilizer was investigated. We found that the NPs have aqueous pores with diameters up to 13 nm, similar to the ones in the bulk phase.

  19. SEE Measurements and Simulations Using Mono-Energetic GeV-Energy Hadron Beams

    CERN Document Server

    Alia, Ruben Garcia; Brugger, Markus; Roed, Ketil; Uznanski, Slawosz; Wrobel, Frederic; Ferlet-Cavrois, Veronique; Danzeca, Salvatore; Saigne, Frederic; Spiezia, Giovanni

    2013-01-01

    Single Event Upset (SEU) measurements were performed on the ESA SEU Monitor using mono-energetic GeV-energy hadron beams available in the North Experimental Area at CERN. A 400 GeV proton beam in the H4IRRAD test area and a 120 GeV mixed pion and proton beam at the CERN-EU high Energy Reference Field facility (CERF) were used for this purpose. The resulting cross section values are presented and discussed as well as compared to the several hundred MeV case (typical for standard test facilities) from a physical interaction perspective with the intention of providing a more general understanding of the behavior. Moreover, the implications of the cross section dependence with energy above the several hundred MeV range are analyzed for different environments. In addition, analogous measurements are proposed for Single Event Latchup (SEL), motivated by discussed simulation results. Finally, a brief introduction of the future CHARM (CERN High-energy AcceleratoR Mixed facility) test installation is included.

  20. IMMUNOHISTOCHEMICAL ANALYSIS OF CASPASE-3 ACTIVITY IN LIVER BIOPSIES OF PATIENTS WITH MONO AND MIXED INFECTIONS

    Directory of Open Access Journals (Sweden)

    I. I. Tokin

    2015-01-01

    Full Text Available Objective: to study the activity of proapoptotic signal protein caspase-3 for determination of peculiarities of apoptosis regulation under liver chronic diseases.Subjects and methods. The immunohistochemical analysis of caspase-3 activity in 5 liver biopsies of the patients with mono infection of chronic hepatitis B and 5 liver biopsies of the patients with mixed infection of tuberculosis, chronic hepatitis C and human immunodeficiency virus was fulfilled. Morphological and morphometric analysis of serial microphotographs was performed using an image analysis system (microscope Leica DM 2500, digital camera Leica DFC320 R2 and a computer.Results. The activity of caspase-3 as dark brown granularity was revealed in all tis-sue components of liver (hepatocytes, epithelium of bile ducts, endotheliocytes, Kupffer cells of sinusoids, in compositions of lymphohistiocyte infiltrations. The maximal activity was discovered in hepatocytes nuclei. The expression of caspase-3 was significantly higher in liver biopsies of the patients with mixed infection. It is typical that the immunoreactive hepatocytes had not any morphological marks of apoptosis.Conclusion. The caspase-3 expression of proapoptotic signal protein caspase-3 may serve as an early marker of liver damage including the possibilities of apoptosis development.

  1. Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties

    Science.gov (United States)

    Vavříková, Eva; Langschwager, Fanny; Jezova-Kalachova, Lubica; Křenková, Alena; Mikulová, Barbora; Kuzma, Marek; Křen, Vladimír; Valentová, Kateřina

    2016-01-01

    A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside) esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C5- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C2), malonic (C3), succinic (C4) and maleic (C4) acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin–Ciocalteau reagent (FCR) and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) than isoquercitrin; ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging activity was comparable. Dodecanoate and palmitate were the least active in FCR and ABTS scavenging; dodecanoate and hemiglutarate were the strongest DPPH scavengers. In contrast, most derivatives were much better inhibitors of microsomal lipoperoxidation than isoquercitrin; butyrate and hexanoate were the most efficient. Anti-lipoperoxidant activity of monocarboxylic derivatives, except acetates, decreased with increasing aliphatic chain. The opposite trend was noted for dicarboxylic acid hemiesters, isoquercitrin hemidodecanedioate being the most active. Overall, IQ butyrate, hexanoate and hemidodecanedioate are the most promising candidates for further studies. PMID:27338349

  2. Sponge Phases and Nanoparticle Dispersions in Aqueous Mixtures of Mono- and Diglycerides.

    Science.gov (United States)

    Valldeperas, Maria; Wiśniewska, Małgorzata; Ram-On, Maor; Kesselman, Ellina; Danino, Dganit; Nylander, Tommy; Barauskas, Justas

    2016-08-30

    The lipid liquid crystalline sponge phase (L3) has the advantages that it is a nanoscopically bicontinuous bilayer network able to accommodate large amounts of water and it is easy to manipulate due to its fluidity. This paper reports on the detailed characterization of L3 phases with water channels large enough to encapsulate bioactive macromolecules such as proteins. The aqueous phase behavior of a novel lipid mixture system, consisting of diglycerol monooleate (DGMO), and a mixture of mono-, di- and triglycerides (Capmul GMO-50) was studied. In addition, sponge-like nanoparticles (NPs) stabilized by Polysorbate 80 (P80) were prepared based on the DGMO/GMO-50 system, and their structure was correlated with the phase behavior of the corresponding bulk system. These NPs were characterized by dynamic light scattering (DLS), cryo-transmission electron microscopy (Cryo-TEM) and small angle X-ray scattering (SAXS) to determine their size, shape, and inner structure as a function of the DGMO/GMO-50 ratio. In addition, the effect of P80 as stabilizer was investigated. We found that the NPs have aqueous pores with diameters up to 13 nm, similar to the ones in the bulk phase. PMID:27482838

  3. Overview of Mono-Energetic Gamma-Ray Sources and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hartemann, Fred; /LLNL, Livermore; Albert, Felicie; /LLNL, Livermore; Anderson, Scott; /LLNL, Livermore; Barty, Christopher; /LLNL, Livermore; Bayramian, Andy; /LLNL, Livermore; Chu, Tak Sum; /LLNL, Livermore; Cross, R.; /LLNL, Livermore; Ebbers, Chris; /LLNL, Livermore; Gibson, David; /LLNL, Livermore; Marsh, Roark; /LLNL, Livermore; McNabb, Dennis; /LLNL, Livermore; Messerly, Michael; /LLNL, Livermore; Shverdin, Miroslav; /LLNL, Livermore; Siders, Craig; /LLNL, Livermore; Jongewaard, Erik; /SLAC; Raubenheimer, Tor; /SLAC; Tantawi, Sami; /SLAC; Vlieks, Arnold; /SLAC; Semenov, Vladimir; /UC, Berkeley

    2012-06-25

    Recent progress in accelerator physics and laser technology have enabled the development of a new class of tunable gamma-ray light sources based on Compton scattering between a high-brightness, relativistic electron beam and a high intensity laser pulse produced via chirped-pulse amplification (CPA). A precision, tunable Mono-Energetic Gamma-ray (MEGa-ray) source driven by a compact, high-gradient X-band linac is currently under development and construction at LLNL. High-brightness, relativistic electron bunches produced by an X-band linac designed in collaboration with SLAC NAL will interact with a Joule-class, 10 ps, diode-pumped CPA laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. This MEGaray source will be used to excite nuclear resonance fluorescence in various isotopes. Applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. The source design, key parameters, and current status are presented, along with important applications, including nuclear resonance fluorescence.

  4. Properties and applications of mono-energetic gamma-rays from laser-Compton scattering

    Science.gov (United States)

    Albert, Felicie; Anderson, Scott; Anderson, Gerry; Betts, Shawn; Gibson, David; Hagmann, Christian; Johnson, Micah; Messerly, Mike; Shverdin, Miroslav; Hartemann, Frederic; Siders, Craig; McNabb, Dennis; Barty, Christopher

    2009-11-01

    Properties of a Mono-Energetic Gamma-Ray (MEGa-Ray) Compton scattering source are presented. It produces 0.1 MeV-0.9 MeV photons. Its experimental key parameters are: its size (0.01 mm^2), divergence (10x6 mrad^2), duration (ps), spectrum (15% bandwidth) and intensity (10^5 photons/shot), which yield an on-axis peak brightness of ˜10^15 photons/mm^2/mrad^2/s/0.1% bandwidth at 0.478 MeV. We detected the 0.478 MeV nuclear resonance fluorescence (NRF) line of ^7Li. A LiH sample was in the beam path, and the NRF scattered photons were detected by a germanium detector oriented at 90^o with respect to the incident beam axis. The resulting spectrum shows the 0.478 MeV line of ^7Li, with several characteristic lines from the interaction. With this experiment, we have shown that MEGa-Ray sources will provide a unique specific isotope detection capability. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  5. Impulsivity and polysubstance use: A systematic comparison of delay discounting in mono-, dual-, and trisubstance use.

    Science.gov (United States)

    Moody, Lara; Franck, Christopher; Hatz, Laura; Bickel, Warren K

    2016-02-01

    Understanding the association between polysubstance use and impulsivity is pertinent to treatment planning and efficacy. Delay discounting, a measure of impulsivity, supplies the rate at which a reinforcer loses value as the temporal delay to its receipt increases. Excessive delay discounting has been widely observed among drug-using individuals, though the impact of using more than 1 substance has been only minimally studied. Here, after controlling for demographic variables, we systematically compared delay discounting in community controls, heavy smokers, and alcohol- and cocaine-dependent individuals to assess the impact of non-, mono-, dual-, and trisubstance use. All substance-using groups discounted significantly more than did community controls (p dependency discounted significantly more than did the group that smoked cigarettes only (p dependent, cocaine-dependent, and heavy cigarette smokers discounted significantly more than did heavy smokers (p < .01). However, trisubstance users did not discount significantly more than did any dual-substance group. Trisubstance use was associated with greater impulsivity than was monosubstance smoking but exhibited no greater impulsivity than did dual-substance use, suggesting a ceiling effect on discounting when more than 2 substances are in use. The present study suggests that smokers who engage in additional substance use may experience worse treatment outcomes, given that excessive discounting is predictive of poor therapeutic outcomes in several studies. PMID:26691847

  6. Synthesis of mono and multidomain YIG particles by chemical coprecipitation or ceramic procedure

    International Nuclear Information System (INIS)

    Yttrium iron garnet powders have been synthesized by chemical coprecipitation using two different precursors, nitrates and chlorides, and by an oxides mixture route. It is shown that depending on the precursors and synthesis conditions used pure yttrium iron garnet powders can be obtained with a mono or multidomain magnetic behaviour. The yttrium iron garnet crystalline structure, as studied by Raman spectroscopy, was already formed after calcination at temperatures as low as 800 oC when the nitrate precursors were used. However, calcination temperatures of up to 1100 oC were required to obtain yttrium iron garnet powders when the precursors were chlorides or when the oxides mixture route was chosen. The saturation magnetization of the powders correlates well with the structural characterization: when nitrate precursors were used, the saturation magnetization was already close to the bulk value, 26.8 emu/cm3, after calcination at 800 oC. However, the saturation magnetization of the powders obtained by the chlorides and oxides mixture routes was close to zero up to calcination temperatures of 1100 oC. Finally, both the chlorides and the oxides mixture routes yield multidomain micron sized yttrium iron garnet powders, whereas the nitrates route led to monodomain submicron sized powders.

  7. Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.

    Science.gov (United States)

    Kistler, Martin; Muntean, Andreea; Szymczak, Wilfried; Rink, Nadine; Fuchs, Helmut; Gailus-Durner, Valerie; Wurst, Wolfgang; Hoeschen, Christoph; Klingenspor, Martin; Hrabě de Angelis, Martin; Rozman, Jan

    2016-03-01

    The prevalence of obesity is still rising in many countries, resulting in an increased risk of associated metabolic diseases. In this study we aimed to describe the volatile organic compound (VOC) patterns symptomatic for obesity. We analyzed high fat diet (HFD) induced obese and mono-genetic obese mice (global knock-in mutation in melanocortin-4 receptor MC4R-ki). The source strengths of 208 VOCs were analyzed in ad libitum fed mice and after overnight food restriction. Volatiles relevant for a random forest-based separation of obese mice were detected (26 in MC4R-ki, 22 in HFD mice). Eight volatiles were found to be important in both obesity models. Interestingly, by creating a partial correlation network of the volatile metabolites, the chemical and metabolic origins of several volatiles were identified. HFD-induced obese mice showed an elevation in the ketone body acetone and acrolein, a marker of lipid peroxidation, and several unidentified volatiles. In MC4R-ki mice, several yet-unidentified VOCs were found to be altered. Remarkably, the pheromone (methylthio)methanethiol was found to be reduced, linking metabolic dysfunction and reproduction. The signature of volatile metabolites can be instrumental in identifying and monitoring metabolic disease states, as shown in the screening of the two obese mouse models in this study. Our findings show the potential of breath gas analysis to non-invasively assess metabolic alterations for personalized diagnosis. PMID:26860833

  8. Nickel Electroless Plating: Adhesion Analysis for Mono-Type Crystalline Silicon Solar Cells.

    Science.gov (United States)

    Shin, Eun Gu; Rehman, Atteq ur; Lee, Sang Hee; Lee, Soo Hong

    2015-10-01

    The adhesion of the front electrodes to silicon substrate is the most important parameters to be optimized. Nickel silicide which is formed by sintering process using a silicon substrate improves the mechanical and electrical properties as well as act as diffusion barrier for copper. In this experiment p-type mono-crystalline czochralski (CZ) silicon wafers having resistivity of 1.5 Ω·cm were used to study one step and two step nickel electroless plating process. POCl3 diffusion process was performed to form the emitter with the sheet resistance of 70 ohm/sq. The Six, layer was set down as an antireflection coating (ARC) layer at emitter surface by plasma enhanced chemical vapor deposition (PECVD) process. Laser ablation process was used to open SiNx passivation layer locally for the formation of the front electrodes. Nickel was deposited by electroless plating process by one step and two step nickel electroless deposition process. The two step nickel plating was performed by applying a second nickel deposition step subsequent to the first sintering process. Furthermore, the adhesion analysis for both one step and two steps process was conducted using peel force tester (universal testing machine, H5KT) after depositing Cu contact by light induced plating (LIP). PMID:26726421

  9. Strain-modulated excitonic gaps in mono- and bi-layer MoSe2

    Science.gov (United States)

    Jianting, Ji; Anmin, Zhang; Tianlong, Xia; Po, Gao; Yinghao, Jie; Qian, Zhang; Qingming, Zhang

    2016-07-01

    Photoluminescence (PL) and Raman spectra under uniaxial strain were measured in mono- and bi-layer MoSe2 to comparatively investigate the evolution of excitonic gaps and Raman phonons with strain. We observed that the strain dependence of excitonic gaps shows a nearly linear behavior in both flakes. One percent of strain increase gives a reduction of ∼ 42 meV (∼ 35 meV) in A-exciton gap in monolayer (bilayer) MoSe2. The PL width remains little changed in monolayer MoSe2 while it increases rapidly with strain in the bilayer case. We have made detailed discussions on the observed strain-modulated results and compared the difference between monolayer and bilayer cases. The hybridization between 4d orbits of Mo and 4p orbits of Se, which is controlled by the Se–Mo–Se bond angle under strain, can be employed to consistently explain the observations. The study may shed light into exciton physics in few-layer MoSe2 and provides a basis for their applications. Project supported by the National Basic Research Program of China (Grant No. 2012CB921701) and the National Natural Science Foundation of China (Grant Nos. 11474357 and 11004245). Qingming Zhang and Tianlong Xia were supported by the Fundamental Research Funds for the Central Universities of China and the Research Funds of Renmin University of China.

  10. Substituent effects in the 13C NMR chemical shifts of alpha-mono-substituted acetonitriles.

    Science.gov (United States)

    Reis, Adriana K C A; Rittner, Roberto

    2007-03-01

    13C chemical shifts empirical calculations, through a very simple additivity relationship, for the alpha-methylene carbon of some alpha-mono-substituted acetonitriles, Y-CH(2)-CN (Y=H, F, Cl, Br, I, OMe, OEt, SMe, SEt, NMe(2), NEt(2), Me and Et), lead to similar, or even better, results in comparison to the reported values obtained through Quantum Mechanics methods. The observed deviations, for some substituents, are very similar for both approaches. This divergence between experimental and calculated, either empirically or theoretically, values are smaller than for the corresponding acetones, amides, acetic acids and methyl esters, which had been named non-additivity effects (or intramolecular interaction chemical shifts, ICS) and attributed to some orbital interactions. Here, these orbital interactions do not seem to be the main reason for the non-additivity effects in the empirical calculations, which must be due solely to the magnetic anisotropy of the heavy atom present in the substituent. These deviations, which were also observed in the theoretical calculations, were attributed in that case to the non-inclusion of relativistic effects and spin-orbit coupling in the Hamiltonian. Some divergence is also observed for the cyano carbon chemical shifts, probably due to the same reasons.

  11. Mono or 3D video production for scientific dissemination of nuclear energy applications

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Victor Goncalves G.; Mol, Antonio Carlos A.; Biermann, Bruna; Jorge, Carlos Alexandre F., E-mail: mol@ien.gov.b, E-mail: vgoncalves@ien.gov.b, E-mail: calexandre@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Araujo, Tawein [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola de Belas Artes; Legey, Ana Paula [Universidade Gama Filho (UGF), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

  12. Sustainable design for environment-friendly mono and dicationic cholinium-based ionic liquids.

    Science.gov (United States)

    E Silva, Francisca A; Siopa, Filipa; Figueiredo, Bruna F H T; Gonçalves, Ana M M; Pereira, Joana L; Gonçalves, Fernando; Coutinho, João A P; Afonso, Carlos A M; Ventura, Sónia P M

    2014-10-01

    Cholinium-based ionic liquids are receiving crescent interest in diverse areas of application given their biological compatibility and potential for industrial application. In this work, mono and dicationic cholinium ionic liquids as well as cholinium derivatives were synthesized and their toxicity assessed using the luminescent bacteria Vibrio fischeri. A range of cholinium derivatives was synthesized, using different amines and the correspondent brominated derivatives, through the alkylation of the amine with the halide in MeCN. The results indicate that their toxicity is highly dependent on the structural modifications of the cholinium cation, mainly related to the alkyl side or linkage chain length, number of hydroxyethyl groups and insertion of carbon-carbon multiple bonds. The data indicated that it is possible to perform environmentally advantageous structural alterations, namely the addition of double bonds, which would not negatively affect V. fischeri. Moreover, the dicationic compounds revealed a significantly lower toxicity than the monocationic counterparts. The picture emerging from the results supports the idea that cholinium derivatives are promising ionic liquids with a low environmental impact, emphasizing the importance of a careful and directed design of ionic liquid structures.

  13. A fluorometric assay for measurement of mono-ADP-ribosyltransferase activity.

    Science.gov (United States)

    Klebl, B M; Pette, D

    1996-08-01

    Using 1,N6-etheno NAD, a fluorescent analog of NAD, we extended an existing assay for NAD glycohydrolase to the measurement of mono-ADP-ribosyltransferase (mADP-RT) activity using agmatine as acceptor for ADP-ribose. The reaction products were analyzed by reversed-phase chromatography. In the presence of agmatine two newly formed fluorescent products were tentatively identified as ADP-ribosylagmatine anomers. Fluorescence intensity increased upon splitting the N-glycoside bondage of 1,N6-etheno NAD. Therefore, 1, N6-etheno AMP could be used for calibration. The nonradioactive assay yielded values nearly identical to those obtained with the [carbonyl-14C]NAD method. It proved to be highly reproducible, rapid, and suitable for an improved purification protocol yielding a 76,000-fold enriched mADP-RT preparation from rabbit skeletal muscle. The identity and high purity of the enzyme were confirmed immunochemically. The assay served to determine the pH optimum of the enzyme (pH 9.0) and its KM for 1,N6-etheno NAD (287 microM). PMID:8811894

  14. Mono-(2-Ethylhexyl Phthalate Promotes Pro-Labor Gene Expression in the Human Placenta.

    Directory of Open Access Journals (Sweden)

    Ximi K Wang

    Full Text Available Women exposed to phthalates during pregnancy are at increased risk for delivering preterm, but the mechanism behind this relationship is unknown. Placental corticotropin-releasing hormone (CRH and cyclooxygenase-2 (COX-2 are key mediators of parturition and are regulated by the non-canonical NF-kB (RelB/p52 signaling pathway. In this study, we demonstrate that one of the major phthalate metabolites, mono-(2-ethylhexyl-phthalate (MEHP, increased CRH and COX-2 mRNA and protein abundance in a dose-dependent manner in primary cultures of cytotrophoblast. This was coupled with an increase in nuclear import of RelB/p52 and its association with the CRH and COX-2 promoters. Silencing of NF-kB inducing kinase, a central signaling component of the non-canonical NF-kB pathway, blocked MEHP-induced upregulation of CRH and COX-2. These results suggest a potential mechanism mediated by RelB/p52 by which phthalates could prematurely induce pro-labor gene activity and lead to preterm birth.

  15. Chiral separation of benzoporphyrin derivative mono- and diacids by laser induced fluorescence-capillary electrophoresis.

    Science.gov (United States)

    Peng, Xuejun; Sternberg, Ethan; Dolphin, David

    2002-01-01

    A method for the separation of benzoporphyrin derivative mono- and diacid (BPDMA, BPDDA) enantiomers by laser induced fluorescence-capillary electrophoresis (LIF-CE) has been developed. By using 300 mM borate buffer, pH 9.2, 25 mM sodium cholate and 10% acetronitrile as electrolyte, +10 kV electrokinetic sampling injection of 2 s and an applied +20 kV voltage across the ends of a 37 cm capillary (30 cm to the detector, 50 microm ID), all six BPD stereoisomers were baseline-separated within 20 min. Formation constants, free electrophoretic and complexation mobilities with borate and cholate were determined based on dynamic complexation capillary electrophoresis theory. The BPD enantiomers can be quantitatively determined in the range of 10(-2)-10(-5) mg mL(-1). The correlation coefficients (r2) of the least-squares linear regression analysis of the BPD enantiomers are in the range of 0.9914-0.9997. Their limits of detection are 2.18-3.5 x 10(-3) mg mL(-1). The relative standard deviations for the separation were 2.90-4.64% (n = 10). In comparison with high-performance liquid chromatography (HPLC), CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes. PMID:11824627

  16. Effects of mono- and disaccharides on the antimicrobial activity of bovine lactoperoxidase system.

    Science.gov (United States)

    Al-Baarri, Ahmad Nimatullah; Hayashi, Makoto; Ogawa, Masahiro; Hayakawa, Shigeru

    2011-01-01

    The effects of mono- and disaccharides on the antimicrobial activity of the lactoperoxidase (LPO) system against Salmonella Enteritidis were investigated. The results clearly reveal that most of the sugars inhibit the antimicrobial activity of the LPO system. The inhibitory potency varies depending on the structure of sugar. L-Fructose and D-allose were strongly inhibitive to the action of the LPO system, while sucrose was the weakest inhibitor. The decreased antimicrobial activity is due to the reduction of LPO catalytic activity by sugar. An inhibitory kinetic study showed the noncompetitive inhibitor. D-Allose and L-fructose yielded strikingly low K(i) values of 0.36 and 0.42 mM, respectively, while the K(i) values of the other sugars ranged from 1.37 to 3.60 mM. Since LPO activity is inhibited by the saccharides, the sugar content in food should be considered when the LPO system is applied to the preservation of food.

  17. Seasonal variation of mono- and sesquiterpenoid components in the essential oil of Dracocephalum kotschyi Boiss.

    Directory of Open Access Journals (Sweden)

    G. Asghari

    2014-10-01

    Full Text Available Background and objectives: Dracocephalum kotschyi is a plant which belongs to the Lamiaceae family and exists mostly in south-west Asian countries, including Iran. This plant is used as antispasmodic, analgesic and anti-inflammatory to treat rheumatoid diseases. Methods: In order to investigate the impact of the harvesting time changes on the quantity and quality of mono- and sesquiterpenoid components of D. kotschyi aerial parts, ten samples were collected from cultivated plants from 19 April to 27 August 2013. Also samples of flower and root were harvested in order to investigate their essential oil components. The essential oils were obtained through hydrodistillation method. The components were studied and identified by GC and GC ⁄ MS systems. Results: The highest yield of the essential oil was obtained on 3 May (1.10% V.W and the lowest on 28 July (0.29% V.W. Totally 55 compounds were identified in the essential oil while the highest percentage belonged to monoterpenes especially the oxygenated ones. Most variations were observed in geraniol (1.40-15.34%, geranyl acetate (trace-14.41% and neryl acetate (0.62-17.51%. The major value in most cases belonged to geranial. Conclusion: the results of this study indicate that the harvesting time of plant is an effective factor in the quality and quantity of theessential oil of Dracocephalum kotschyi.

  18. Prediction of mono- and polycyclic aromatic hydrocarbon degradation in spiked soils using cyclodextrin extraction

    International Nuclear Information System (INIS)

    In this study, an aqueous-based hydroxypropyl-β-cyclodextrin (HPCD) extraction technique was assessed for its capacity to determine the microbially degradable fraction of mono- and polycyclic aromatic hydrocarbons in four dissimilar soils. A linear relationship (slope = 0.90; R 2 = 0.89), approaching 1:1 between predicted and observed phenanthrene mineralization, was demonstrated for the cyclodextrin extraction; however, the water only extraction underestimated the microbially available fraction by a factor of three (slope = 3.35; R 2 = 0.64). With respect to determining the mineralizable fraction of p-cresol in soils, the cyclodextrin extraction (slope = 0.94; R 2 = 0.84) was more appropriate than the water extraction (slope = 1.50; R 2 = 0.36). Collectively, these results suggested that the cyclodextrin extraction technique was suitable for the prediction of the mineralizable fraction of representative PAHs and phenols present in dissimilar soils following increasing soil-contaminant contact times. The assessment of the microbial availability of contaminants in soils is important for a more representative evaluation of soil contamination. - An aqueous-based HPCD extraction technique was more appropriate than the water extraction in prediction of the mineralizable fraction of phenanthrene and p-cresol present in a range of dissimilar soils

  19. Efficient accumulation of antiprotons and positrons, production of slow mono-energetic beams, and their applications

    CERN Document Server

    Yamazaki, Yasunori

    2004-01-01

    Recent progress of ASACUSA (Atomic Spectroscopy And Collisions Using Slow Antiprotons) project, particularly the antiproton trapping and slow antiproton production, is discussed. An RFQD (Radio Frequency Quadrupole Decelerator) installed in the ASACUSA beam line has an excellent deceleration efficiency of 25% providing 10-130keV antiprotons, which improves the final accumulation efficiency at least one and half orders of magnitude. The decelerated antiprotons are then injected in a large volume multiring trap, stored, and electron-cooled. About 1 million antiprotons are successfully accumulated per one AD shot and 10-500eV antiprotons are extracted as a mono-energetic beam. A UHV compatible positron accumulation is newly developed combining electron plasma and an ion cloud, which yields an accumulation rate as high as 400e **+s/mCi, two and a half orders of magnitude higher than other UHV compatible schemes. A new scheme to synthesize a spin-polarized antihydrogen beam is also discussed, which will play a vit...

  20. Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents

    Directory of Open Access Journals (Sweden)

    Jing Zhang

    2014-11-01

    Full Text Available The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO, relative to currently available inotropic drugs, has prompted us to intensively research and develop LZDO as a potent positive inotropic agent. In this study, to obtain LZDO alternatives for oral chronic administration, a series of long-chain fatty carboxylic mono- and dual-esters of LZDO were synthesized, and preliminarily evaluated for physicochemical properties and bioconversion. Enhanced lipophilic properties and decreased solubility of the prodrugs were observed as the side chain length increased. All esters showed conspicuous chemical stability in phosphate buffer (pH 7.4. Moreover, the enzymatic hydrolysis of esters in human plasma and human liver microsomes confirmed that the majority of esters were converted to LZDO, with release profiles that varied due to the size and structure of the side chain. In vivo pharmacokinetic studies following oral administration of monopivaloyl (M5, monodecyl (M10 and monododecyl (M12 esters demonstrated the evidently extended half-lives relative to LZDO dosed alone. In particular the monopivaloyl ester M5 exhibited an optimal pharmacokinetic profile with appropriate physiochemical characteristics.

  1. Modulation of Recombinant Human α1 Glycine Receptors by Mono- and Disaccharides: A Kinetic Study.

    Science.gov (United States)

    Breitinger, Ulrike; Sticht, Heinrich; Breitinger, Hans-Georg

    2016-08-17

    Glycine receptors (GlyRs) mediate fast synaptic inhibition in spinal cord, brainstem, and higher brain centers. Recently, glucose was identified as a positive modulator of GlyR-mediated currents. Here, we investigated extent and kinetics of the positive modulation of recombinant human α1 glycine receptors by different mono- and disaccharides and sorbitol using patch-clamp recording techniques. Glucose and fructose augmented glycine-mediated whole-cell currents with an EC50 of 6-7 mM. At concentrations > 10 mM, the maximum of current enhancement was reached within ∼30 min. Kinetics of GlyR modulation resemble those of protein glycation. On-rates were 24 h). Galactose, the C4-epimer of glucose, and the sugar alcohol sorbitol had no effect on GlyR currents. Recent cryoelectron microscopy structures were used to identify a potential binding site for saccharides near the ivermectin binding pocket with lysine 143 as possible attachment site. The GlyR mutant α1(K143A) was not potentiated by glucose, suggesting an involvement of this residue in glycine receptor modulation by saccharides. PMID:27227552

  2. Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.

    Science.gov (United States)

    Vavříková, Eva; Langschwager, Fanny; Jezova-Kalachova, Lubica; Křenková, Alena; Mikulová, Barbora; Kuzma, Marek; Křen, Vladimír; Valentová, Kateřina

    2016-01-01

    A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside) esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C₅- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C₂), malonic (C₃), succinic (C₄) and maleic (C₄) acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin-Ciocalteau reagent (FCR) and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) than isoquercitrin; ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging activity was comparable. Dodecanoate and palmitate were the least active in FCR and ABTS scavenging; dodecanoate and hemiglutarate were the strongest DPPH scavengers. In contrast, most derivatives were much better inhibitors of microsomal lipoperoxidation than isoquercitrin; butyrate and hexanoate were the most efficient. Anti-lipoperoxidant activity of monocarboxylic derivatives, except acetates, decreased with increasing aliphatic chain. The opposite trend was noted for dicarboxylic acid hemiesters, isoquercitrin hemidodecanedioate being the most active. Overall, IQ butyrate, hexanoate and hemidodecanedioate are the most promising candidates for further studies. PMID:27338349

  3. Contribution of mono and polysaccharides to heterotrophic N2 fixation at the eastern Mediterranean coastline.

    Science.gov (United States)

    Rahav, E; Giannetto, M J; Bar-Zeev, E

    2016-01-01

    N2 fixation should be a critical process in the nitrogen-poor surface water of the eastern Mediterranean Sea. Despite favorable conditions, diazotroph abundance and N2 fixation rates remains low for reasons yet explained. The main goal of this study was to investigate the limiting nutrients for diazotrophy in this oligotrophic environment. Hence, we conducted dedicated bottle-microcosms with eastern Mediterranean Sea water that were supplemented with mono and polysaccharides as well as inorganic nitrogen and phosphorous. Our results indicate that the diazotrophic community expressing nifH was primarily represented by heterotrophic Proteobacteria. N2 fixation and heterotrophic bacterial activity increased up-to tenfold following two days of dark incubations, once seawater was supplemented with organic carbon substrate in the form of glucose (monosaccharides) or gum-xanthan (polysaccharide surrogate). Furthermore, our results point that carbon-rich polysaccharides, such as transparent exopolymer particles, enhance heterotrophic N2 fixation, by forming microenvironments of intense metabolic activity, high carbon: nitrogen ratio, and possibly low O2 levels. The conclusions of this study indicate that diazotrophs in the eastern Mediterranean coast are primarily limited by organic carbon substrates, as possibly in many other marine regions. PMID:27306501

  4. Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis.

    Science.gov (United States)

    Chien, Ting-Yi; Huang, Steven Kuan-Hua; Lee, Chia-Jung; Tsai, Po-Wei; Wang, Ching-Chiung

    2016-01-01

    The fresh rhizome of Zingiber zerumbet Smith (Zingiberaceae) is used as a food flavoring and also serves as a folk medicine as an antipyretic and for analgesics in Taiwan. Zerumbone, a monocyclic sesquiterpene was isolated from the rhizome of Z. zerumbet and is the major active compound. In this study, the anti-inflammatory and antinociceptive effects of zerumbone on arthritis were explored using in vitro and in vivo models. Results showed that zerumbone inhibited inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase (COX)-2 expressions, and NO and prostaglandin E₂ (PGE₂) production, but induced heme oxygenase (HO)-1 expression in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. When zerumbone was co-treated with an HO-1 inhibitor (tin protoporphyrin (SnPP)), the NO inhibitory effects of zerumbone were recovered. The above results suggest that zerumbone inhibited iNOS and COX-2 through induction of the HO-1 pathway. Moreover, matrix metalloproteinase (MMP)-13 and COX-2 expressions of interleukin (IL)-1β-stimulated primary rat chondrocytes were inhibited by zerumbone. In an in vivo assay, an acetic acid-induced writhing response in mice was significantly reduced by treatment with zerumbone. Furthermore, zerumbone reduced paw edema and the pain response in a mono-iodoacetate (MIA)-induced rat osteoarthritis model. Therefore, we suggest that zerumbone possesses anti-inflammatory and antinociceptive effects which indicate zerumbone could be a potential candidate for osteoarthritis treatment. PMID:26901193

  5. The valuation of malnutrition in the mono-digestion of maize silage by anaerobic batch tests.

    Science.gov (United States)

    Hinken, L; Urban, I; Haun, E; Urban, I; Weichgrebe, D; Rosenwinkel, K-H

    2008-01-01

    Anaerobic digestion is a technology which is used to produce methane from organic solids and energy crops. Especially in recent years, the fermentation of energy crops has become more and more important because of increasing costs for energy and special benefits for renewable energy sources in Germany. Anaerobic bacteria require macro and micro nutrients to grow. Absence of these elements can inhibit the anaerobic process significantly. In particular mono-substrates like maize or certain industrial wastewater often cannot provide all required nutrients. For this reason this research investigates the influence of substrate and trace elements on anaerobic digestion in detail. Different agricultural anaerobic biomasses are analysed with special regard to their trace element content. Based on these results, the influence of three trace elements (iron, cobalt, and nickel) on anaerobic digestion was studied in anaerobic batch tests at different sludge loading rates and for different substrates (maize and acetate). Biogas production was found to be 35% for maize silage and up to 70% higher for acetate with trace element dosage than in the reference reactor. PMID:18957759

  6. MonoTrap法捕集白木香愈伤组织挥发性成分及其GC-MS分析%GC-MS Analysis on the Volatile Constituents Adsorbed with Mono Trap from Callus of Aquilaria sinensis (Lour.) Gilg

    Institute of Scientific and Technical Information of China (English)

    张珂; 陈华姑; 龚胜; 孙海燕; 王健

    2015-01-01

    采用新型材料MonoTrap作为顶空固相萃取的吸附剂,捕集茉莉酸甲酯(MeJA)处理后的白木香愈伤组织挥发性成分,并应用GC-MS分析测定其化学成分及相对含量.结果表明,从MeJA不同处理下的白木香愈伤组织中共鉴定出56种挥发物成分,主要成分为脂肪烃类、芳香族类和倍半萜类等成分;通过正交实验法确定最佳捕集方法为:不破碎愈伤组织材料,于30℃条件下、采用MonoTrap捕集6h.MonoTrap法结合气质联用具有高灵敏度、强针对性和可操作性强的优点,可以为白木香的开发利用提供理论依据.

  7. Synthesis of some new mono, bis-indolo[1, 2-c]quinazolines: evaluation of their antimicrobial studies

    Energy Technology Data Exchange (ETDEWEB)

    Rohini, Rondla; Reddy, P. Muralidhar; Shanker, Kanne; Ravinder, Vadde, E-mail: ravichemku@rediffmail.co [Kakatiya University, Warangal, A.P. (India). Dept. of Chemistry; Hu, Anren, E-mail: anren@mail.tcu.edu.t [Tzu Chi University, Hualien (China). Dept. of Laboratory Medicine and Biotechnology

    2010-07-01

    A convenient three-step strategy is proposed for the synthesis of mono and bis-indolo[1,2-c] quinazolines from 2-(2-aminophenyl)indole and various aryl aldehydes. The newly synthesized compounds were characterized by elemental analysis, IR, {sup 1}H NMR, {sup 13}C NMR, and mass spectroscopic investigation. All the derivatives were screened for antibacterial (S. aureus, B. subtilis, S. pyogenes, S. typhimurium, E. coli, K. pneumonia) and antifungal (A. niger, C. albicans, T. viridae) activities by cup plate method. Among the compounds tested, mono- indolo[1,2-c] quinazolines (15-18) exhibited good antibacterial activities while 15 and 18 also showed notable antifungal activity. Especially, 19 and 20 exhibited stronger antibacterial as well as antifungal activity against all tested strains. (author)

  8. A putative flavin-containing mono-oxygenase as a marker for certain defense and cell death pathways

    DEFF Research Database (Denmark)

    Olszak, Brian; Malinovsky, Frederikke Gro; Brodersen, Peter;

    2006-01-01

    mRNA of the putative Arabidopsis flavin mono-oxygenase encoded by At1g19250 (here designated AtFMO GenBank accession no. NM_101783 ) accumulated to high levels in the acd11 and lsd1 mutants that exhibit run-away cell death, but not in mutants with constitutive defense responses. AtFMO mRNA accumu......mRNA of the putative Arabidopsis flavin mono-oxygenase encoded by At1g19250 (here designated AtFMO GenBank accession no. NM_101783 ) accumulated to high levels in the acd11 and lsd1 mutants that exhibit run-away cell death, but not in mutants with constitutive defense responses. AtFMO m...

  9. Search for Mono-Higgs Signals at the LHC in the B-L Supersymmetric Standard Model

    CERN Document Server

    Abdallah, W; Khalil, S; Moretti, S

    2016-01-01

    We study mono-Higgs signatures emerging in the $B-L$ supersymmetric standard model induced by new channels not present in the minimal supersymmetric standard model, i.e., via topologies in which the mediator is either a heavy $Z'$, with mass of ${\\cal O}(2~{\\rm TeV})$, or an intermediate $h'$ (the lightest CP-even Higgs state of $B-L$ origin), with mass of ${\\cal O}(0.2~{\\rm TeV})$. The mono-Higgs probe considered is the SM-like Higgs state recently discovered at the large hadron collider, so as to enforce its mass reconstruction for background reduction purposes. With this in mind, its two cleanest signatures are selected: $\\gamma\\gamma$ and $ZZ^*\\to 4l$ ($l=e,~\\mu$). We show how both of these can be accessed with foreseen energy and luminosity options using a dedicated kinematic analysis performed in presence of partonic, showering, hadronisation and detector effects.

  10. Numerical Study of Injection Mechanisms for Generation of Mono-Energetic Femtosecond Electron Bunch from the Plasma Cathode

    CERN Document Server

    Ohkubo, Takeru; Zhidkov, Alexei

    2005-01-01

    Acceleration gradients of up to the order of 100GV/m and mono-energetic electron bunch up to 200MeV have recently been observed in several plasma cathode experiments. However, mechanisms of self-injection in plasma are not sufficiently clarified, presently. In this study, we carried out 2D PIC simulation to reveal the mechanisms of mono-energetic femtosecond electron bunch generation. We found two remarkable conditions for the generation: electron density gradient at vacuum-plasma interface and channel formation in plasma. Steep electron density gradient (~ plasma wave length) causes rapid injection and produces an electron bunch with rather high charge and less than 100fs duration. The channel formation guides an injected laser pulse and decreases the threshold of laser self-focusing, which leads to high electric field necessary for wave-breaking injection.

  11. Hydrolysis of p-Nitrophenyl Picolinate Catalyzed by Mono-and Binuclear Transition Metal Complexes with Polyether Bridged Dihydroxamic Acid

    Institute of Scientific and Technical Information of China (English)

    李建章; 李鸿波; 冯发美; 谢家庆; 李慎新; 周波; 秦圣英

    2005-01-01

    Two polyether bridged dihydroxamic acids and their mono-and binuclear manganese(Ⅱ), zinc(Ⅱ) complexes have been synthesized and employed as models to mimic hydrolase in catalytic hydrolysis of p-nitrophenyl picolinate (PNPP). The reaction kinetics and the mechanism of hydrolysis of PNPP have been investigated. The kinetic mathematical model for PNPP cleaved by the complexes has been proposed. The effects of the different central metal ion, mono-and binuclear metal, the pseudo-macrocyclic polyether constructed by polyethoxy group of the complexes, and reactive temperature on the rate for catalytic hydrolysis of PNPP have been examined. The results showed that the transition metal dthydroxamates exhibited high catalytic activity to the hydrolysis of PNPP, the catalytic activity of binuclear complexes was higher than that of mononuclear ones, and the pseudo-macrocyclic polyether might synergetically activate H20 coordinated to metal ion with central metal ion together and promote the catalytic hydrolysis of PNPP.

  12. Reliability design of mono-leaf spring for front-axle suspension of large-sized trucks

    Energy Technology Data Exchange (ETDEWEB)

    Savaidis, G. [Aristotle Univ. of Thessaloniki, Dept. of Mechanical Engineering (Greece); Schwaiger, F. [MAN Nutzfahrzeuge AG, Munich (Germany); Momiyama, F.; Yamazumi, T.; Muramatsu, K. [Horikiri Inc., Chiba-Pref. (Japan)

    2004-07-01

    This paper deals with the development of a fatigue-accurate suspension system for large-sized trucks based on mono-leaf steel springs, It shows the fulfillment of the demands for lightweight construction, sufficient fatigue life and fail-safe behaviour. The paper contains the fatigue load assumptions used for the non-linear finite-element stress-strain analysis, the experimental verification by means of measured load, stress and strain data determined by driving quasi-static manoeuvres and over various rough road segments with a prototype vehicle, as well as the experimental uniaxial and multiaxial fatigue tests required for the durability approval. The fatigue lives achieved, confirm the adequate service life of the developed spring. In addition, appropriate vehicle tests on a test track with a custom-made mono-leaf spring system confirmed the fail-safe design of the suspension system. (orig.)

  13. Gas chromatography determination of fatty acid alkyl esters (methyl and ethyl in the presence of mono., di- and triglycerides

    Directory of Open Access Journals (Sweden)

    Paulo César Narváez Rincón

    2010-04-01

    Full Text Available Determining fatty acid methyl or ethyl esters, in the presence of mono-, di- and tri glycerides, is very important when studying fatty compounds' methanolysis or ethanolysis, as well as for controlling the quality of petrochemical products. This work presents a useful technique for determining fatty acids methyl or ethyl esters by high temperature gas chromastography in the presence of mono-, di- and triglycerides. Samples were silylated with N, O-bis (trimethylsilyl trifluroacetamide (BSTFA and then passed throught a 12m HT5 column coated with a phenyl-polysiloxane-carborane film. Standard methyl and ethyl palmitate, methyl and ethyl oleate, DL-palmitin, dipalmitin, tripalmitin and triolein solutions were used for calibrating the technique, using tricaprin as internal standard. Retention times and response factors were also determined. The results were employed in following-up palm oil methanolysis and ethanolysis reactions.

  14. Fabrication of a Mono-Domain Alignment Ferroelectric Liquid Crystal Device Using a Polar Self-Assembled Monolayer

    Institute of Scientific and Technical Information of China (English)

    ZOU Zhong-Fei; YAO Li-Shuang; TANG Xian-Zhu; JI Xin-Jian; XUAN Li

    2008-01-01

    A mono-domain ferroelectric liquid crystal device (FLCD) is fabricated using a novel method. The cell used in this method is an asymmetric cell, typically the combination of a polar self-assembled monolayer (SAM) for one substrate and a rubbed polyimide for the other substrate. A defect-free alignment of ferroelectric liquid crystal is fabricated without applying a dc voltage to remove degeneracy in the layer structure. The contact angles of self-assembled monolayer and PI-2942 are measured and the polarity of SAM is higher than the PI alignment. It is found that the polarity of self-assembled monolayer is a key factor in the formation of mono-domain alignment of FLC.

  15. Bayesian risk maps for Schistosoma mansoni and hookworm mono-infections in a setting where both parasites co-exist

    Directory of Open Access Journals (Sweden)

    Giovanna Raso

    2007-11-01

    Full Text Available There is growing interest in the use of Bayesian geostatistical models for predicting the spatial distribution of parasitic infections, including hookworm, Schistosoma mansoni and co-infections with both parasites. The aim of this study was to predict the spatial distribution of mono-infections with either hookworm or S. mansoni in a setting where both parasites co-exist. School-based cross-sectional parasitological and questionnaire surveys were carried out in 57 rural schools in the Man region, western Côte d’Ivoire. A single stool specimen was obtained from each schoolchild attending grades 3-5. Stool specimens were processed by the Kato-Katz technique and an ether concentration method and examined for the presence of hookworm and S. mansoni eggs. The combined results from the two diagnostic approaches were considered for the infection status of each child. Demographic data (i.e. age and sex were obtained from readily available school registries. Each child’s socio-economic status was estimated, using the questionnaire data following a household-based asset approach. Environmental data were extracted from satellite imagery. The different data sources were incorporated into a geographical information system. Finally, a Bayesian spatial multinomial regression model was constructed and the spatial patterns of S. mansoni and hookworm mono-infections were investigated using Bayesian kriging. Our approach facilitated the production of smooth risk maps for hookworm and S. mansoni mono-infections that can be utilized for targeting control interventions. We argue that in settings where S. mansoni and hookworm co-exist and control efforts are under way, there is a need for both mono- and co-infection risk maps to enhance the cost-effectiveness of control programmes.

  16. Specific Character of Linguistic Personality Development in Mono- and Poly-ethnic Environment (the Kabardino-Balkarian Republic Case Study)

    OpenAIRE

    Madina B. Bezrokova

    2013-01-01

    This article generalizes the results of sociolinguistic poll, conducted in the Kabardino-Balkarian Republic, which enabled to determine the features of linguistic personality development in mono- and poly-ethnic environment. Linguistic personality development is affected by many linguistic and extra-linguistic factors, playing significant role in the process of his/her formation. These include primary extra-linguistic factors, such as sex, age, place of residence and place of birth, ethnicity...

  17. Correlation of Late Pleistocene Terrestrial Climate Variation From Mono Lake, USA, With Global Records Using Relative Paleointensity

    Science.gov (United States)

    Zimmerman, S.; Hemming, S.; Kent, D.

    2004-12-01

    In order to assess different models of global climate variation, it is crucial to be able to accurately correlate terrestrial climate records with each other and with marine climate records. This problem is especially challenging in intervals older than 30 kyr, when problems with accuracy and precision of 14C ages become significant. Recently published stacks of global, high-resolution variation in intensity of Earth's past magnetic field (North and South Atlantic PaleoIntensity Stacks, NAPIS and SAPIS) enable correlation of high-quality terrestrial records of paleointensity with the GISP2 timescale. The lacustrine sediments of the Wilson Creek Formation (Mono Basin, CA) are known to be excellent recorders of Pleistocene climate and geomagnetic field variation, and are the type locality for the Mono Lake paleomagnetic excursion (MLE). Here we present rock magnetic analyses showing that the sediments also fit the criteria required for good recorders of paleomagnetic intensity, with a magnetic fraction dominated by fine-grained magnetite with concentration variation lakes of the Great Basin have been shown to be strongly controlled by the 100 ka cycle, and so we infer lake transgression over the Wilson Creek site at the M.I.S. 5/4 boundary, fixing the maximum age of sediment deposition. We then use distinctive features of the Mono and global paleo-intensity records to refine the correlation, resulting in an age of 68 ka for the oldest sediments, and 40 ka for the MLE, coeval with the Laschamp excursion. Finally, we compare climatic proxies measured at Mono to regional and global records, with major changes in glacial proxies at M.I.S. 4/3 boundary and evidence for low lake levels at the time of Heinrich events.

  18. Ichtyofaune du bassin du fleuve Mono (Bénin et Togo): diversité, écologie et impacts anthropiques

    OpenAIRE

    Lederoun, Djiman

    2015-01-01

    This study has three main objectives: (1) to obtain an inventory of the ichthyofauna of the Mono River that is as complete as possible; (2) to study the ecology of this ichthyofauna; and (3) to document the impact of fishing on the exploited stocks based on two targeted species. The inventory was made by compiling the literature, by studying collections of museums and of other institutions and by several sampling campaigns, conducted between February 2011 and March 2014. This resulted in an i...

  19. Ceric Ion Loaded MCM-41 Catalyzed Synthesis of Substituted Mono- and Bis-dihydropyrimidin-2(1H)-ones

    OpenAIRE

    Pullar Vadivel; Rathinam Ramesh; Appaswami Lalitha

    2013-01-01

    An effective one-pot three-component reaction of aromatic aldehydes with 1,3-diketone and urea or thiourea under solvent-free condition leads to the formation of mono- and bis-dihydropyrimidin-2-(1H)-ones using Ce-MCM-41 as a recyclable solid acid catalyst. This method has several advantages like simple and easy work-up with shorter reaction time, reusability of catalyst, and high yields of Biginelli products.

  20. Interaction of Hypocrellin B or Mono-cysteine Substituted Hypocrellin B with CT-DNA by Spectral Methods

    Institute of Scientific and Technical Information of China (English)

    Jia Hong ZHOU; Sheng Qin XIA; Xue Song WANG; Bao Wen ZHANG; Yi CAO

    2003-01-01

    The interaction of the anticancer drag hypocrellin B (HB) or the mono-cysteinesubstituted hypocrellin B (MCHB) and calf thymus deoxyribonucleic acid (CT-DNA) has beeninvestigated using spectral methods. The results of UV-visible spectra show that the HB andMCHB could intercalate into the base-stacking domain of the CT-DNA double helix. The studiesof fluorescence spectra and circular dichroism(CD) spectra also support the interacalationmechanism.