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Sample records for al mono obeso

  1. Assistência ao paciente obeso mórbido submetido à cirurgia bariátrica: dificuldades do enfermeiro Asistencia al paciente obeso mórbido sometido a la cirugía bariátrica: dificultades del enfermero Perioperative care for morbid obese patient undergoing bariatric surgery: challenges for nurses

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    Denise Spósito Tanaka

    2009-10-01

    Full Text Available OBJETIVO: Identificar as dificuldades de enfermeiros de centro cirúrgico ao assistir pacientes obesos mórbidos submetidos à cirurgia bariátrica no período transoperatório. MÉTODOS: A amostra constou de 70 enfermeiros com experiência em assistência ao paciente obeso mórbido. Os dados foram coletados durante o 7º Congresso Brasileiro de Enfermeiros de Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização por meio de um questionário. RESULTADOS: A análise dos resultados apontou como dificuldades aquelas relacionadas ao espaço físico, materiais e equipamentos e à assistência de enfermagem específica ao paciente obeso mórbido. CONCLUSÃO: O conhecimento específico, a especialização e a experiência em Centro Cirúrgico darão o conforto, a segurança física e emocional necessárias a estes pacientes.OBJETIVO: Identificar las dificultades de enfermeros de centro quirúrgico en el cuidado a pacientes obesos mórbidos sometidos a cirugía bariátrica en el período transoperatorio. MÉTODOS: La muestra constó de 70 enfermeros con experiencia en asistencia al paciente obeso mórbido. Los datos fueron recolectados por medio de un cuestionario durante el 7º Congreso Brasileño de Enfermeros de Centro Quirúrgico, Recuperación Anestésica y Centro de Material y Esterilización. RESULTADOS: El análisis de los resultados identificó como dificultades aquellas relacionadas al espacio físico, materiales y equipos y a la asistencia de enfermería específica al paciente obeso mórbido. CONCLUSIÓN: El conocimiento específico, la especialización y la experiencia en Centro Quirúrgico darán el confort, la seguridad física y emocional que necesitan estos pacientes.OBJECTIVE: To identify the challenges for nurses during the perioperative for patients undergoing bariatric surgery. METHODS: The sample consisted of 70 nurses who had experience in providing care for morbid obese patients. Data were collected

  2. Peroxidación de lípidos y la respuesta del sistema de defensa antioxidante en el diabético tipo 2 obeso en comparación al diabético tipo 2 sin obesidad

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    Ramón Gaxiola-Robles

    2013-12-01

    Full Text Available Introducción: La diabetes se asocia a un incremento en la peroxidación de lípidos, cuantificada a partir del nivel de sustancias reactivas al ácido tiobarbitúrico (TBARS. En paralelo, se activa el sistema de defensa antioxidante (SDA para delimitar el daño. Objetivo: Determinar el grado de peroxidación de lípidos en individuos obesos diabéticos tipo 2 (DM2 y la respuesta del SDA en comparación con individuos con DM2 sin obesidad. Método: Se evaluó el daño a lípidos a través de la medición de las TBARS en dos grupos de 30 individuos. Se evaluó la respuesta del SDA por medio de la medición de la actividad de las enzimas catalasa (CAT, superóxido dismutasa (SOD y glutatión peroxidasa (GPx. Resultados: El grupo de DM2 obesos presentó un índice de masa corporal (IMC promedio de 38,6 ± 3,5 kg m² en comparación con el grupo control 24,7 ± 3,6 kg m² (p < 0,01. Los niveles de TBARS en el grupo en estudio fueron más altos en comparación al grupo control (p < 0.01. En un análisis de regresión lineal múltiple la actividad de SOD y CAT explicó los niveles de TBARS en el obeso con DM2. Conclusión: Los niveles de TBARS sugieren mayor daño por estrés oxidativo en DM2 obesos por un exceso en la producción de radicales libres (RL, así como incapacidad del SDA para delimitar el daño.

  3. 7th to 9th grade obese adolescents’ perceptions about obesity in tamaulipas, Mexico Percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado residentes en Tamaulipas, México Percepções da obesidade de adolescentes obesos, estudantes do 7º ao 9º grau residentes em Tamaulipas, México

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    Ma. de la Luz Martínez-Aguilar

    2010-02-01

    Full Text Available The objective was to explore obese adolescents’ perceptions about obesity among students in the seventh to ninth grade of a public school in Tamaulipas, Mexico. This is a qualitative study. Participants were 24 adolescents with a body mass index equal to or greater than the 95th percentile. Semistructured interviews were conducted until data saturation was reached and the meaning was understood. The adolescents defined obesity according to standards of measurement. They identified the hereditary factor as the main obesity cause, tended to underestimate obesity and had low self-esteem. They reported problems to do physical exercise and get clothes in order to improve their image, and feel rejected by their peers in school. It was identified that these adolescents have psychological defense mechanisms against obesity and that some of them are making efforts to lose weight. Obesity entails social and psychological health implications for persons suffering from this problem. Interventions should be put in practice.El objetivo de esta investigación fue explorar las percepciones de la obesidad de adolescentes obesos estudiantes del 7º al 9º grado de una institución pública en Tamaulipas, México. Se trata de un estudio cualitativo en el cual participaron 24 adolescentes que tenían un índice de masa corporal superior al percentil 95. Se realizaron entrevistas semiestructuradas hasta obtener la saturación de los datos y la comprensión del significado. Los adolescentes definieron la obesidad de acuerdo a los estándares de medición, identificaron como causa principal el factor hereditario, tendieron a subestimar la obesidad y presentaron baja autoestima, relataron problemas cuando realizan actividad física y para conseguir ropa que pudiese mejorar su imagen, y se sienten rechazados por sus pares o iguales en la escuela. Se identificó que cuentan con mecanismos psicológicos de defensa ante la obesidad y algunos de ellos están realizando

  4. Allelic frequency of G380A polymorphism of tumor necrosis factor alpha gene and relation with cardiovascular risk factors and adipocytokines in obese patients Frecuencia alélica del polimorfismo G380A del factor de necrosis tumoral alpha y relación con factores de riesgo cardiovascular y adipocitoquinas en pacientes obesos

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    D. A. De Luis

    2011-08-01

    Full Text Available Background: The aim of our study was to investigate the allelic frequency of the G308A polymorphism in the TNF alpha gene and the influence of G308A this polymorphism on cardiovascular risk factors and adipokine levels in obese patients. Design: A population of 834 obesity patients was analyzed. A nutritional evaluation and a blood analysis were performed. The statistical analysis was performed for the combined G308A and A308A as mutant group and type G308G as wild group. Results: A total of 630 patients (181 males/449 females (75.5% had the genotype G308/G308 (wild genotype group with an average age of 43.5 ± 14.8 years, 188 patients (61 males/127 females (22.5% had the genotype G308/A308 (mutant genotype group-heterozygote and 16 patients (5 males/11 females (1.9% with an average age of 44.5 ± 14.2 years had the genotype A308/A308 (mutant group-homorozygote with an average age of 44.3 ± 11.4 years, without statistical differences in the mean age or sex distribution. Genotypes G308/A308 and A308/A308 was designed (mutant genotype group as a dominant model. Allelic frequency of the A substitucion -308 was 13.19%. Anthropometric, adipokines, insulin resistance, lipid levels ad dietary intake were similar in both genotypes. Conclusion: In conclusion, allelic frequency of G308A polymorphism is is in accordance with allelic frequencies observed in other populations. Carries of A308 allele have the same anthropometric and metabolic profile than wild type carriers.Antecedentes: El objetivo de nuestro estudio fue investigar la frecuencia alélica del polimorfismo G308A del gen TNF alfa y su influencia en los factores de riesgo cardiovascular y los niveles de adipocinas en pacientes obesos. Diseño: Se estudió una población de 834 pacientes obesos. Se realizaron una evaluación nutricional y un análisis de sangre. El análisis estadístico se realizó para el genotipo combinado G308A y A308A como grupo de mutantes y G308G tipo de grupo salvaje

  5. Escala de VO2pico em adolescentes obesos e não-Obesos por diferentes métodos Escala de VO2pico en adolescentes obesos y no obesos por diferentes métodos Scale of VO2peak in obese and non-obese adolescents by different methods

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    Gerusa Eisfeld Milano

    2009-12-01

    estrategia atractiva para comparar individuos con grandes diferencias en la masa corporal. OBJETIVO: Investigar el VO2pico en individuos obesos y no obesos usando el método de corrección de masa corporal (convencional y la escala alométrica (método alométrico y cómo esos métodos se aplican cuando individuos de ambos sexos se ejercitan en una cinta ergométrica. MÉTODOS: El VO2pico relativo al peso corporal y por el método alométrico fue comparado en 54 adolescentes obesos y 33 no obesos (10-16 años. Para evaluar el VO2pico durante un test máximo se utilizó calorimetría indirecta. El exponente alométrico fue calculado considerando la masa corporal individual. Así, el VO2pico fue corregido mediante el exponente alométrico. Las comparaciones se realizaron utilizando two-way ANOVA para medidas repetidas (p0,05. Sin embargo, el VO2pico calculado por el método convencional fue mayor (p0.05 entre los grupos. CONCLUSIÓN: Los individuos obesos presentaron VO2pico más bajo que los no obesos, al ser evaluados mediante el método convencional. Sin embargo, las diferencias desaparecieron cuando se aplicó el método de la escala alométrica.BACKGROUND: Peak oxygen uptake (VO2peak can be defined as the highest oxygen rate consumed during exhaustive or maximal exercise. The evaluation of the aerobic fitness can be expressed as relative to body mass, but this procedure may not fully remove differences when heavy subjects are assessed. Thus, the allometric scaling procedure is an attractive strategy to compare individuals with large differences in body mass. OBJECTIVE: Investigate VO2peak in obese and non-obese individuals using body mass correction (conventional and allometric scaling (allometric methods and how these methods apply when subjects of different genders exercise on a treadmill. METHODS: VO2peak relative to body weight and measured by the allometric method were compared in 54 obese and 33 non-obese adolescents (10 a 16 years. Indirect calorimetry was used to

  6. Respuesta al tratamiento periodontal de diabéticos tipo 2 con mal control metabólico y obesos intolerantes a la glucosa, con periodontitis severa Impact of the periodontal therapy in both clinical and metabolic parameters in type 2 diabetic and prediabetic obese patients with severe periodontitis

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    V Pavez Correa

    2011-08-01

    Full Text Available Diabetes Mellitus (DM es un factor de riesgo para periodontitis, a su vez, el control metabólico de los diabéticos se dificulta por la presencia de la infección periodontal, aumentando el riesgo de complicaciones crónicas y eventualmente, la mortalidad por diabetes. Ambas enfermedades se relacionan porque los mediadores de inflamación generados en la infección periodontal y la translocación de bacterias de la cavidad oral a la circulación sistémica, podrían actuar como agravantes de la insulino resistencia y deteriorar el control glicémico. Es evidente que el tratamiento oportuno de la periodontitis mejoraría la calidad de vida de los diabéticos; ayudándolos a alcanzar y mantener un adecuado control metabólico. El presente estudio evaluó el impacto de un protocolo de terapia periodontal en parámetros clínicos y metabólicos de pacientes DM2 y obesos prediabéticos, con el fin de contribuir a la inclusión de los diabéticos descompensados y prediabéticos en tratamientos periodontales exitosos, sin aumentar su riesgo médico. Se seleccionó a 9 individuos con DM2 descompensados y 7 obesos intolerantes a la glucosa, todos con Periodontitis Crónica Generalizada Severa. Los pacientes fueron sometidos a tratamiento periodontal, sin modificar las indicaciones médicas, de acuerdo a un protocolo diseñado por nosotros. Los diabéticos mostraron una leve disminución en la HbA1c a los 6 meses de realizado el tratamiento periodontal, no se registraron complicaciones, ni perdieron su condición de pacientes ambulatorios. La respuesta al tratamiento periodontal, fue similar en ambos grupos, con mejoría en todos los parámetros clínicos. Aunque los resultados obtenidos no son estadísticamente significativos, son muy promisorios.Diabetes Mellitus (DM is a risk factor for periodontitis, at the same time, the metabolic control of diabetic patients gets more difficult due to the presence of periodontal infection, increasing the risk of

  7. Interface Entre Obesos Severos e Atividade Laboral Relacionada a Alimentos

    OpenAIRE

    2011-01-01

    A obesidade é uma doença multifatorial e envolve um grande número de determinantes na sua etiologia. O preconceito social a que o obeso é submetido pode ser mais prejudicial do que os problemas de saúde decorrentes da “doença”. O objetivo deste estudo foi investigar a interface entre obesos severos e a atividade laboral relacionada a alimentos. Trata-se de uma pesquisa do tipo transversal, descritiva e documental, que envolve indivíduos de ambos os sexos, portadores de obesidade severa cadast...

  8. Aspectos socioeconómicos y familiares asociados en niños y adolescentes obesos

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    William José González Cabriles

    2013-01-01

    Full Text Available El estudio es transversal y correlacional donde se analizaron las variables socioeconómicas y familiares de una muestra no probabilística, constituida por 528 familias de niños con obesidad exógena, de 2 a 18 años, provenientes de diversos sectores del país, atendidos en la consulta de primera del Centro de Atención Nutricional Infantil Antímano. El objetivo fue determinar los aspectos socioeconómicos y familiares asociados en niños y adolescentes con obesidad que asistieron al Centro. Los datos se procesaron con el programa SPSS 9.0. Se analizaron las distribuciones de frecuencias y el estadístico Chi-cuadrado para probar asociación entre las variables. El nivel de significancia fue 95%. En las familias de niños obesos se encontró que la mayoría de los jefes de familia eran obesos; las familias con pobreza extrema y la población infantil mayor de 15 años presentaron mayor sedentarismo; por último, las madres en general no participaron en la toma de decisiones en la compra de alimentos y no poseían nociones de alimentación equilibrada que les permitieran planificar la compra de alimentos. Estos aspectos se erigen como claves para ser abordados y resueltos por el trabajador social durante la intervención con el fin de favorecer la recuperación nutricional del niño obeso y su familia.

  9. Guía de Atención de Enfermería en Pacientes Obesos sometidos a Cirugía General en el Instituto Médico Tierra Nueva.

    OpenAIRE

    Falcón Querido, Nancy Marlene; Zapata Lucero, Ana Lucía

    2014-01-01

    El personal que labora en el Centro Quirúrgico del Instituto Médico Tierra Nueva, tiene varias falencias en el desenvolvimiento de sus actividades con el cuidado de pacientes obesos sometidos a cirugía general durante el proceso quirúrgico, debido al trabajo estresante y bajo presión que existe en este lugar. Es prioridad la implementación de una Guía de Atención de Enfermería, para proporcionar al paciente obeso cuidados específicos con fundamento científico, logrando de esta manera dism...

  10. Installation of a mono pile as a foundation structure of a tidal turbine; Installation eines Monopfahls als Gruendungsstruktur fuer eine Gezeitenturbine

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Stefan [BAUER Spezialtiefbau GmbH, Schrobenhausen (Germany). Bautechnik; Bauer, Thomas [BAUER AG, Schrobenhausen (Germany)

    2012-11-01

    Tidal turbines enable a power generation from the flow energy of the sea. Usually heavy weight structures are used for the foundation of tidal turbines. However, these heavy weight structures are not fixed to the bottom of the sea. A mono pile being embedded in the bottom of the sea is an alternative which is a significant benefit for operators of tidal turbine operator.

  11. Mastigação e deglutição de crianças e adolescentes obesos

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    Noemia Caroline de Souza

    Full Text Available RESUMO Objetivo: caracterizar o perfil miofuncional orofacial de crianças e adolescentes com obesidade comparados a um grupo de eutróficos e verificar quais aspectos influenciam as funções de mastigação e deglutição. Métodos: foram avaliados os órgãos do sistema estomatognático, a mastigação e a deglutição aplicando o protocolo de Avaliação Miofuncional Orofacial com Escores Expandidos (AMIOFE-E em 50 indivíduos do sexo feminino e masculino, com idades entre 9 e 18 anos, atendidos em um ambulatório de Nutrologia. Eles foram divididos em dois grupos, o grupo pesquisa, de obesos, e o grupo controle, de eutróficos. Os testes estatísticos utilizados foram: análise de variância (ANOVA, Teste Exato de Fisher, Intervalo de Confiança para Média e Coeficiente da Variação. Resultados: os obesos, quando comparados aos eutróficos, apresentaram pior desempenho nos aspectos de tonicidade e mobilidade de bochechas e na deglutição (p<0,05, sendo que 71% dos indivíduos com redução da tonicidade apresentaram deglutições múltiplas contra 25% dos indivíduos eutróficos. Além disso, 68% das crianças e adolescentes obesos dessa pesquisa apresentaram mastigação bilateral alternada. Conclusão: as crianças e adolescentes obesos estudados nessa pesquisa apresentaram maior ocorrência de alterações miofuncionais orofaciais quando comparados aos eutróficos em relação à tonicidade e mobilidade de bochechas e na deglutição. Nesta pesquisa também houve associação estatística entre a redução da tonicidade de bochechas das crianças e adolescentes obesos e a presença de deglutições múltiplas durante a deglutição.

  12. Estrés oxidativo, nitrosativo y daño cardiovascular en pacientes pediátricos obesos.

    OpenAIRE

    Tavárez Alonso, Sandra

    2015-01-01

    La obesidad predispone fuertemente al riesgo cardiovascular y se relaciona con alteraciones en diferentes marcadores de funcionalidad del tejido adiposo, inflamación y daño a biomoléculas. Establecer la presencia de alteraciones precoces en la obesidad infantil es el objetivo de este estudio realizado en pacientes pediátricos (7-14 años) obesos (N=60) y controles (N=42). En él hemos evaluado como marcadores de estrés oxidativo y nitrosativo los niveles de malondialdehído, 8-isoprostanos, pro...

  13. Adversidade na infância, características psicológicas e problemas de saúde física: comparação entre obesos e não obesos

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    Susana Sofia Pereira da Silva

    2011-01-01

    Full Text Available INTRODUÇÃO: A literatura é unânime sobre a elevada morbilidade e mortalidade associada à obesidade, mas pouco consistente no que se refere às características psicológicas dos obesos. OBJETIVO: O objetivo deste estudo é caracterizar as experiências de vida e os problemas de saúde física e mental de um grupo de obesos e compará-los com sujeitos não obesos. MÉTODO: Oitenta e um obesos e cem não obesos foram avaliados quanto às experiências adversas na infância, psicopatologia geral, dimensões de personalidade, estilos de coping e problemas e queixas de saúde. RESULTADOS: As experiências de abuso emocional e de negligência são frequentemente relatadas, mas algumas experiências de adversidade na infância são pouco relatadas pelos obesos e não obesos. Os obesos relatam mais queixas, problemas de saúde física e menos coping, mas os não obesos apresentam valores médios de psicopatologia superiores. Nas dimensões de personalidade, não se verifica qualquer diferença entre os grupos. A psicopatologia geral, as estratégias de coping, as queixas de saúde e os problemas de saúde distinguem obesos de não obesos. CONCLUSÃO: Contrariamente ao que sugerem alguns estudos, os obesos não relatam mais adversidade e relatam menos psicopatologia geral do que os não obesos. No entanto, apresentam mais queixas e problemas de saúde e usam estratégias de coping de forma diferente.

  14. Diferencias clínicas y polisomnográficas entre obesos y no obesos con síndrome de apneas-hipopneas del sueño Clinical and polysomnographyc differences between obese and non obese patients with obstructive sleep apnea-hypopnea syndrome

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    Jorge Rey de Castro

    2011-12-01

    Full Text Available Objetivos. Describir las diferencias clínicas y polisomnográficas en pacientes obesos y no obesos con diagnóstico del síndrome de apneas-hipopneas del sueño (SAHS. Materiales y métodos. A los pacientes incluidos se les realizó un examen físico, se aplicó la escala de somnolencia de Epworth (ESE y además se les realizó una polisomnografía. Se consideró obeso si el índice de masa corporal (IMC era mayor o igual a 30 kg/m2. Resultados. Se analizaron 408 pacientes con SAHS, de estos, 119 (47 % fueron obesos. El SAHS fue leve en 101 (25 %, moderado en 91 (22 % y severo en 216 (53 %. No hubo diferencias por sexo, edad y puntaje ESE al compararse obesos con no obesos. La diferencias del perímetro cervical y presencia de somnolencia según ESE fue significativamente mayor en obesos. Estos tuvieron mayor comorbilidad en términos de dislipidemia, hipertensión arterial y enfermedad coronaria. De las variables polisomnográficas, los índices de eventos respiratorios fueron mayores en obesos, asimismo fueron peores los valores de saturación de oxígeno. No hubo diferencias en el resto de variables. El análisis de regresión mostró asociación entre la obesidad y la severidad del SAHS. Conclusiones. El SAHS no es una enfermedad limitada a la población obesa, aunque esta última tienen mayor comorbilidad y formas más severas de enfermedad.Objectives. To describe the clinical and polysomnographyc differences between obese and non- obese patients with obstructive sleep apnea-hypopnea (OSAH syndrome. Materials and methods. A physical examination, the Epworth Sleepiness Scale (ESS and a polysomnography were performed to all included patients. Obesity was defined as a body mass index (BMI of ≥ 30 kg/m2. Results. 408 patients with OSAH were analyzed, out of these, 119 (47 % were obese. OSAH was mild in 101 (25 %, moderate in 91 (22 % and severe in 216 (53 %. There were no age, sex and EES score differences between obese and non

  15. Dal poli-logo al mono-logo: Un monologo del principe Myškin per il balletto-pantomima L’Idiota

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    Enza Dammiano

    2012-12-01

    Full Text Available Il Monologo del principe Myškin (Ein Monolog des Fürsten Myschkin zu der Ballettpantomime Der Idiot composto da Ingeborg Bachmann per il balletto-pantomima L’Idiota, si presenta come ri-composizione lirica del romanzo dostoevskijano. Musicata dal compositore Hans Werner Henze con coreografie di Tatjana Gsovsky, l’opera fu pubblicata nella seconda edizione della raccolta Il tempo dilazionato (Die gestundete Zeit, 1953 e rappresentata per la prima volta solo nel gennaio del 1960. Il monologo affida al principe Myškin le diverse voci di quella complessa ‘partitura’ che è L’Idiota: i suoi protagonisti diventano i personaggi della pantomima; le vicende narrate si trasfigurano in passi di danza; mentre il principe Myškin assume l’unica voce lirica che emerge dal silenzio. L’analisi comparata delle due opere mette in luce un molteplice passaggio di codice, in cui il tessuto dialogico, o meglio poli-logico, della narrazione dostoevskjana si riconfigura in parola poetica: il principe Myškin avanza sulla scena, attraversa il silenzio fino a un’afasica incoscienza che si sublima nel connubio di musica e danza.

  16. Efeitos de diferentes graus de sensibilidade a insulina na função endotelial de pacientes obesos

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    Roberto Galvão

    2012-01-01

    Full Text Available FUNDAMENTO: A obesidade derivada da deposição de gordura intra-abdominal tende a aumentar a produção de hormônios e citoquinas, piorando a sensibilidade a insulina e levando a disfunção endotelial. A hiperinsulinemia é considerada um fator de risco independente para doença isquêmica cardíaca e é uma causa de disfunção endotelial em indivíduos saudáveis. OBJETIVO: Avaliar o impacto de diferentes graus de resistência a insulina, medida pelo HOMA-IR (Homeostasis Model Assessment of Insulin Resistance, sobre a função endotelial de obesos, pacientes não diabéticos, sem história prévia de eventos cardiovasculares e diversos componentes da síndrome metabólica. MÉTODOS: Um total de 40 indivíduos obesos foi submetido a medidas antropométricas, pressão arterial de consultório, MAPA e exames laboratoriais, além de avaliação ultrassonográfica não invasiva da função endotelial. Os pacientes foram divididos em três grupos de acordo com o grau de resistência a insulina: pacientes com valores de HOMA-IR entre 0,590 e 1,082 foram incluídos no Grupo 1 (n = 13; entre 1,083 e 1,410 no Grupo 2 (n = 14; e entre 1,610 e 2,510 no Grupo 3 (n = 13. RESULTADOS: Encontramos uma diferença significativa na vasodilatação mediada por fluxo no Grupo 3 em relação ao Grupo 1 (9,2 ± 7,0 vs 18,0 ± 7,5 %, p = 0,006. Houve uma correlação negativa entre a função endotelial e insulina, HOMA-IR e triglicérides. CONCLUSÃO: Nosso estudo sugere que leves alterações nos níveis de resistência a insulina avaliada pelo HOMA-IR podem causar algum impacto sobre a função vasodilatadora do endotélio em indivíduos obesos não complicados com diferentes fatores de risco cardiovascular.

  17. Problemas clínicos pré-anestésicos de pacientes morbidamente obesos submetidos a cirurgias bariátricas: comparação com pacientes não obesos Problemas clínicos pré-anestésicos de pacientes mórbidamente obesos sometidos a cirugías bariátricas: comparación con pacientes no obesos Preanesthetic clinical problems of morbidly obese patients submitted to bariatric surgery: comparison with non-obese patiens

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    Getúlio Rodrigues de Oliveira Filho

    2002-04-01

    átricas, imponiendo nuevos desafíos al anestesiólogo. Este estudio comparó la prevalencia de problemas clínicos entre pacientes mórbidamente obesos sometidos a cirugías bariátricas y no obesos sometidos a otros procedimientos electivos. MÉTODO: Fueron estudiados, retrospectivamente, los registros electrónicos de 2986 pacientes divididos en grupo 1, obesos mórbidos sometidos a cirugías bariátricas y grupo 2, con índice de masa corporal menor que 30, sometidos a otros procedimientos electivos, relacionados al grupo 1 por la edad, sexo y estado físico (ASA. Los problemas pré-anestésicos del grupo 1 fueron pesquisados en el grupo 2 y las prevalencias comparadas. Las razones de chance (RC y respectivos limites de 95% de confianza (LC 95% fueron calculados. RESULTADOS: Los problemas identificados nos grupos 1 y 2 y sus respectivas prevalencias fueron: reflujo gastroesofágico (16,67% y 0,48%, hipertensión arterial sistémica (50% y 3,06%, diabetes mellitus tipo II (6,25% y 0,31%, hipotiroidismo (6,25% y 0,31%, asma bronquica (10,42% y 1,43% y pneumopatia restrictiva (10,42% y 0,03%. Las prevalencias fueron significativamente mas altas en el grupo 1. Fueron también identificados, en el grupo 1, los siguientes problemas que no fueron encontrados en el grupo 2: epilepsia (2,08%, esteatosis hepática (12,5%, colecistopatia calculosa (6,25%, dislipidemia (20,83% e hipopituitarismo (2,08%. CONCLUSIONES: La prevalencia de problemas clínicos es significativamente mas alta en pacientes portadores de obesidad mórbida de que en no obesos de la misma edad, sexo y estado físico.BACKGROUND AND OBJECTIVES: Morbid obesity is associated to clinical problems responsible for decreased life expectancy. Morbidly obese patients are candidates to gastric bypass and pose new challenges to the anesthesiologist. This study compared the prevalence of clinical problems among morbidly obese patients submitted to bariatric surgery to non-obese patients submitted to other elective surgical

  18. Broncoespasmo induzido pelo exercício em adolescentes asmáticos obesos e não-obesos Exercise-induced bronchospasm in obese and non-obese asthmatic adolescents

    Directory of Open Access Journals (Sweden)

    Wendell Arthur Lopes

    2010-03-01

    Full Text Available OBJETIVO: Avaliar e comparar a frequência e intensidade do broncoespasmo induzido pelo exercício (BIE em adolescentes asmáticos obesos e não-obesos. MÉTODOS: Estudo transversal e descritivo realizado com 39 adolescentes de ambos os sexos, com idade entre dez e 16 anos, divididos em dois grupos conforme o histórico clínico de asma e/ou rinite alérgica e o índice de massa corporal: asmáticos obesos (n=18; asmáticos não-obesos (n=21. Utilizou-se o teste de broncoprovocação com exercício para a avaliação do BIE, considerando-se positiva uma diminuição do volume expiratório forçado no primeiro segundo (VEF1 >15% do valor pré-exercício. Para avaliar a intensidade e a recuperação do BIE, foram calculadas a queda percentual máxima do VEF1 (QM%VEF1 e a área acima da curva (AAC0-30. A análise estatística utilizou o teste exato de Fischer para comparar a frequência de BIE e o teste de Mann-Whitney para a intensidade e recuperação. Rejeitou-se a hipótese de nulidade se pOBJECTIVE: To assess and compare the frequency and severity of exercise-induced bronchospasm (EIB in obese and non-obese asthmatic adolescents. METHODS: Cross-sectional and descriptive study with 39 subjects aged ten to 16 years of both genders divided into two groups according to clinical history of asthma and/or allergic rhinitis and body mass index, as follows: asthmatic obese (n=18 and asthmatic non-obese (n=21. An exercise bronchoprovocation test was applied to diagnose EIB and was considered positive if the forced expiratory volume in one second (FEV1 decreased >15% in relation to pre-exercise FEV1. Maximum percent of fall in FEV1 (MF%FEV1 and the area above the curve (AAC0-30 were calculated to evaluate the intensity and recovery of EIB. Fisher exact test was used to compare the frequency of EIB and Mann-Whitney test to compare the severity and recovery of EIB. Null hypothesis was rejected when p<0.05. RESULTS: No significant difference was found in

  19. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2

    Directory of Open Access Journals (Sweden)

    Cabrera-Pivaral Carlos Enrique

    2004-01-01

    Full Text Available La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos de pacientes diabéticos obesos. La intervención educativa-participativa se organizó mediante el proceso de reflexión-acción. Se efectuaron mediciones del IMC basal y mensuales durante los 9 meses de la intervención educativa. Los grupos fueron controlados tomando en cuenta edad y sexo. El análisis estadístico se efectuó con el estadígrafo de t de students con diferencia de media para grupos relacionados. El grupo control logra un valor promedio de IMC basal de 33.89 ± 1.96 y al final de 33.2 ± 2.15 (t: 22.4; p: 0.16, el grupo de experimento con valor inicial de 33.63 ± 2.12 y final de 31.54 ± 1.71 (t: 11.55; p = 0.003. La intervención educativa participativa contribuye a mejorar el nivel de IMC en los diabéticos obesos 2.

  20. How Long Is Mono Contagious?

    Science.gov (United States)

    ... it is contagious. Once someone gets mono, the virus stays in that person's body for life. That doesn't mean that you are always ... as long as 18 months. After that, the virus remains dormant (inactive) in the body for the rest of a person's life. If you've had mono, the virus can ...

  1. Perfiles psicopatológicos de niños obesos y desnutridos medidos con el CBCL/6-18

    Directory of Open Access Journals (Sweden)

    Verónica Portillo-Reyes

    2016-01-01

    Full Text Available Los objetivos de este trabajo fueron definir los trastornos psicopatológicos más comunes asociados a la obesidad y a la desnutrición, así como establecer el grupo de referencia normativo al cual pertenece México en la escala Child Behavior Checklist 6-18 (CBCL/6-18. Este fue un estudio transversal de dise˜no cuasiexperiemental. Se utilizó la información de 125 ni˜nos de escuelas públicas de Ciudad Juárez, Chihuahua, México, en estados de desnutrición, obesidad y normopeso, obtenida mediante las 113 preguntas relacionadas con el comportamiento de ni˜nos, que contiene el CBCL 6-18. Por medio de análisis de varianzas se estudiaron las posibles diferencias entre los grupos. Encontramos que nuestra muestra mexicana, pertenece al grupo normativo de referencia tres; las diferencias más significativas se encuentran en el grupo de obesos en las escala de problemas internalizados específicamente en ansiedad/depresión, y en el total de problemas.

  2. Considerações acerca da avaliação psicológica das comorbidades psiquiátricas em obesos Consideraciones sobre la evaluación psicológica de las comorbidades psiquiátricas en obesos Consideration about psychological assessment of psychiatric co morbidity in obese

    Directory of Open Access Journals (Sweden)

    Fabiana Silva Costa

    2009-06-01

    Full Text Available Pretende-se neste artigo apresentar uma revisão teórica sobre avaliação psicológica, obesidade e comorbidades psiquiátricas mais frequentes na população obesa. A obesidade é uma doença clínica de múltiplas causas, e atualmente é considerada uma epidemia; assim seu adequado entendimento deve envolver uma equipe composta por diversos profissionais de saúde, incluindo o psicólogo. Serão abordadas questões pertinentes ao tema de obesidade, como etiologia, incidência e a relação entre obesidade e transtornos psiquiátricos. Serão propostos alguns instrumentos com o objetivo de estruturar informações necessárias ao tratamento e à demanda do paciente obeso, e reflexões referentes à avaliação psicológica em obesos e a prática do profissional de psicologia.Se pretiende en ese artículo presentar una revisión teórica sobre la evaluación psicológica, obesidad y comorbidades psiquiátricas más frecuentes en esa población. La obesidad es una enfermedad clínica con diversas causas y actualmente es considerada una epidemia, así el adecuado entendimiento de la obesidad debe involucrar un equipo compuesto por diversos profesionales de salud, incluso el psicólogo. En ese artículo serán abordadas cuestiones pertinentes a la temática de la obesidad, como etiología, prevalencia y la relación entre obesidad y los trastornos psiquiátricos. Serán propuestos algunos instrumentos* con el objetivo de estructurar informaciones necesarias al tratamiento y a la demanda del paciente obeso, reflexiones referentes a la evaluación psicológica en obesos y la práctica del profesional de PsicologíaWe intend in this article to present a theoretical review about psychological assessment, obesity and psychiatric co morbidity. Obesity is a clinical illness, it has multi factorial causes, and nowadays it is considered an epidemic, so the right knowledge must involve all health professional, include the psychologist. In this article we

  3. Well-defined mono(η3-allyl)nickel complex MONi(η3-C3H5) (M = Si or Al) grafted onto silica or alumina: A molecularly dispersed nickel precursor for syntheses of supported small size nickel nanoparticles

    KAUST Repository

    Li, Lidong

    2014-01-01

    Preparing evenly-dispersed small size nickel nanoparticles over inert oxides remains a challenge today. In this context, a versatile method to prepare supported small size nickel nanoparticles (ca. 1-3 nm) with narrow size distribution via a surface organometallic chemistry (SOMC) route is described. The grafted mono(η3-allyl)nickel complexes MONi(η 3-C3H5) (M = Si or Al) as precursors are synthesized and fully characterized by elemental analysis, FTIR spectroscopy and paramagnetic solid-state NMR. © 2014 the Partner Organisations.

  4. Mono pile foundation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lyngesen, S.; Brendstrup, C.

    1997-02-01

    The use of mono piles as foundations for maritime structures has been developed during the last decades. The installation requirements within the offshore sector have resulted in equipment enabling driving of piles up to 3-4 m to large penetration depths. The availability of this equipment has made the use of large mono piles feasible as foundations for structures like wind turbines. The mono pile foundations consists of three parts; the bare pile, a conical transition and a boat landing. All parts are prefitted at the yard in order to minimise the installation work that has to be carried out offshore. The study of a mono pile foundations for a 1.5 MW wind turbine has been conducted for two locations, Horns Rev and Roedsand. Three different water depths: 5, 8 and 11 m have been investigated in the study. The on-site welding between pile and conical transition is performed by an automatic welding machine. Final testing and eventually repair of the weld are conducted at least 16 hours after welding. This is followed by final installation of J-tube, tie-in to subsea cables and installation of the impressed current system for corrosive protection of the mono pile. The total cost for procurement and installation of the mono pile using the welded connection is estimated. The price does not include procurement and installation of access platform and boat landing. These costs are estimated to 250.000 DKK. Depending on water depth the cost of the pile ranges from 2,2 to 2,7 million DKK. Procurement and fabrication of the pile are approx. 75% of the total costs. The remaining 25% are due to installation. The total costs are very sensitive to the unit price of pile steel. During the project it became obvious that ice load has a very large influence on the dimensions of the mono pile. (EG)

  5. Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon

    DEFF Research Database (Denmark)

    Davidsen, Rasmus Schmidt; Schmidt, Michael Stenbæk; Boisen, Anja

    2013-01-01

    We use plasma etched Black Si (BS)[1][2] nanostructures to achieve low reflectance due to the resulting graded refractive index at the Si-air interface. The goal of this investigation is to develop a suitable texturing method for Si solar cells. Branz et al. [3]report below 3% average reflectance...... advantages such as; (i) excellent light trapping, (ii) dry, single-sided and scalable process method and (iii) etch independence on crystallinity of Si, RIE-texturing has so far not been proven superior to standard wet texturing, primarily as a result of lower power conversion efficiency due to increased...... using maskless RIE in a O2 and SF6 plasma, and the surface topology was optimized for solar cell applications by varying gas flows, pressure, power and process time. The starting substrates were 156x156 mm p-type, CZ mono-, multi- and quasi-mono crystalline Si wafers, respectively, with a thickness...

  6. Festival nimega Mono / Ivar Sakk

    Index Scriptorium Estoniae

    Sakk, Ivar, 1962-

    2015-01-01

    Haapsalu graafilise disaini festival Haapsalu Linnagaleriis: sisaldab ülevaate- ja teemanäitust ning väikest sümpoosioni. Temaatilise aastanäituse motiiv on "MONO". Plakateid on ka välismaa tegijatelt. Kuraator Marko Kekishev

  7. Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos

    Directory of Open Access Journals (Sweden)

    Ana Paula Lima-Leopoldo

    2011-09-01

    Full Text Available FUNDAMENTO: Vários mecanismos têm sido propostos contribuir para a disfunção cardíaca em modelos de obesidade, tais como alterações nas proteínas do trânsito de cálcio (Ca+2 e nos receptores beta-adrenérgicos. Todavia, o papel desses fatores no desenvolvimento da disfunção miocárdica induzida pela obesidade ainda não está claro. OBJETIVO: Este estudo pretende investigar se a obesidade induzida por um ciclo de dieta hipercalóricas resulta em disfunção cardíaca. Além disso, foi avaliado se essa alteração funcional em ratos obesos está relacionada com o prejuízo do trânsito de Ca+2 e do sistema beta-adrenérgico. MÉTODOS: Ratos Wistar machos, 30 dias de idade, foram alimentados com ração padrão (C e um ciclo de cinco dietas hipercalóricas (Ob por 15 semanas. A obesidade foi definida pelo aumento da porcentagem de gordura corporal dos ratos. A função cardíaca foi avaliada mediante análise isolada do músculo papilar do ventrículo esquerdo em condições basais e após manobras inotrópicas e lusitrópicas. RESULTADOS: Em comparação com o grupo controle, os ratos obesos apresentaram aumento da gordura corporal e intolerância a glicose. Os músculos dos ratos obesos desenvolveram valores basais semelhantes; entretanto, as respostas miocárdicas ao potencial pós-pausa e aumento de Ca+2 extracelular foram comprometidas. Não houve alterações na função cardíaca entre os grupos após a estimulação beta-adrenérgica. CONCLUSÃO: A obesidade promove disfunção cardíaca relacionada com alterações no trânsito de Ca+2 intracelular. Esse prejuízo funcional é provavelmente ocasionado pela redução da atividade da bomba de Ca+2 do retículo sarcoplasmático (SERCA2a via Ca+2 calmodulina-quinase.

  8. Atuação ambulatorial do profissional de educação física no atendimento a crianças e adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Perino Barbosa

    1999-02-01

    Full Text Available A freqüência da obesidade na infância e adolescência aumentou nos últimos anos. Essa situação tem preocupado a área da saúde, não só pelas conseqüências promovidas pela obesidade na população em geral, mas pela imposição de prejuízos biopsicossociais, ainda na infância. O tratamento é bastante complexo, pois sua causa é multifatorial, exigindo atenção interdisciplinar. O presente trabalho teve como objetivo relatar o papel do professor de educação física na equipe de atendimento ambulatorial de crianças e adolescentes obesos. A atividade física, depois da taxa metabólica basal, é considerada o segundo maior componente do gasto energético diário. Diversos estudos demonstraram que a atividade física associada ao controle alimentar leva a melhores resultados do que essas ações isoladas. O aumento da atividade física é muito benéfico no tratamento de crianças e adolescentes obesos, pois permite maior ingestão alimentar e auxilia a preservar a massa magra. Entretanto, o exercício físico deve ser adaptado às condições de excesso de peso e de crescimento ósseo. Além desses cuidados, o profissional depara-se com a dificuldade de manter crianças e adolescentes em programa de exercício regular. Desse modo, a prescrição do aumento de movimento corporal após a anamnese da rotina diária de cada paciente foi a solução encontrada para, inicialmente, colocá-los em contato com o próprio corpo. Paralelamente, o professor de educação física auxilia a criança a encontrar um tipo de esporte que mais lhe agrade, dentro daqueles permitidos pelo seu excesso de peso e fase de crescimento. Geralmente, recomendam-se atividades que tenham baixo impacto, como nadar, caminhar e andar de bicicleta. O professor de educação física, como educador, deve fazer parte do atendimento multidisciplinar de crianças e adolescentes obesos.

  9. Método do limiar de variabilidade da frequência cardíaca aplicado em pré-adolescentes obesos e não obesos

    Directory of Open Access Journals (Sweden)

    Mário Augusto Paschoal

    2011-06-01

    Full Text Available FUNDAMENTO: A detecção do limiar anaeróbico (LA pela análise da variabilidade da frequência cardíaca (LiVFC pode significar uma nova maneira de avaliação da capacidade funcional cardiorrespiratória (CFCR em pré-adolescentes. OBJETIVO: Testar o método de LiVFC para detecção do LA em pré-adolescentes não obesos (NO, obesos (O e obesos mórbidas (OM, a fim de determinar diferenças em sua CFCR. MÉTODOS: Foram estudados 30 pré-adolescentes, com idades entre 9 e 11 anos, divididos em três grupos de 10: a grupo NO - índice de massa corpórea (IMC com percentil do National Center for Chronic Disease Prevention and Health Promotion entre 5 e 85; b grupo O - IMC de percentil entre 95 e 97 e c grupo OM - IMC com percentil acima de 97. Todos foram submetidos a um protocolo incremental realizado em esteira rolante e registraram-se os batimentos cardíacos para detecção do LiVFC, que foi determinado pelo valor de 3,0 ms do índice do desvio-padrão 1 (SD1, extraído dos intervalos RR. RESULTADOS: Os valores médios no momento do LiVFC mostraram maiores valores para o grupo NO, destacando-se: a VO2 (ml/kg/min NO = 27,4 ± 9,2; O = 13,1 ± 7,6 e OM = 11,0 ± 1,7; b FC (bpm: NO = 156,3 ± 18,0; O =141,7 ± 11,4 e OM = 137,7 ± 10,4; e c distância percorrida (metros: NO = 1.194,9 ± 427,7; O = 503,2 ± 437,5 e OM = 399,9 ± 185,1. CONCLUSÃO: O LiVFC se mostrou efetivo para avaliação da CFCR e poderá vir a ser aplicado como método alternativo à ergoespirometria em determinadas situações.

  10. Uso de videolaringoscopia para intubación endotraqueal en pacientes obesos

    OpenAIRE

    Suárez Egoávil, Catherine Amparo

    2014-01-01

    Aborda las características de los pacientes obesos en los que se utilizará la videolaringoscopia para la intubación endotraqueal en el Centro Quirúrgico del Hospital Nacional LNS PNP. Para ello, se realizó un estudio prospectivo, longitudinal, descriptivo, observacional. Diseño de una cohorte. Se encontró el 2,21% de obesidad entre los policías evaluados, de los cuales el 43,3% se consideró intubación difícil y se utilizó la videolaringoscopia para la intubación. Respecto a los predictores de...

  11. Análisis de supervivencia de pacientes obesos sometidos a trasplante hepático

    OpenAIRE

    Torres-Quevedo Quevedo, Rodrigo

    2015-01-01

    La prevalencia de obesidad ha aumentado en países en vías de desarrollo, de igual modo en receptores de trasplantes hepático (TH) ésta también se ha incrementado de manera significativa. La obesidad tiene un impacto negativo, en cirugía general y trasplante de órgano sólido. Hasta la fecha existen pocos estudios en TH que analizan el impacto de la obesidad en los resultados del mismo. Objetivo: determinar si existen diferencias en la supervivencia (SV) actuarial a 5 años de obesos y no obe...

  12. A percepção de saúde para adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Maria das Graças Carvalho Ferriani

    2000-12-01

    Full Text Available O presente estudo tem como objetivo conhecer a percepção de saúde para adolescentes obesos que participam do Programa Multidiciplinar de Assistência ao Adolescente Obeso, desenvolvido no Campus de Ribeirão Preto - USP. Foi utilizada a abordagem qualitativa fundamentada em Minayo (1996; os dados foram coletados através de frases e redações de 17 adolescentes integrantes do programa. A análise e interpretação dos dados foi ancorada na técnica de análise temática proposta por Bardin (1977, onde identificou-se os seguintes núcleos de sentido: saúde é beleza, alimentação e higiene e prática de esportes. Assim, o estudo evidenciou que a imagem corporal ideal que o adolescente busca para si, está relacionada com os padrões de beleza ditados pela mídia e com estereótipos de perfeição física. Outro aspecto detectado no estudo, é que os adolescentes têm consciência da importância de praticar esportes e ter uma alimentação balanceada.

  13. Acupuntura e apetite de trabalhadores obesos de um hospital universitário Acupuntura y apetito de trabajadores obesos de un hospital universitario Acupuncture and appetite in obese employees of a university hospital

    Directory of Open Access Journals (Sweden)

    Mariana Lourenço Haddad

    2011-01-01

    Full Text Available OBJETIVO: Mensurar o comportamento da sensação de apetite dos sujeitos antes, durante e após a intervenção de acupuntura. MÉTODOS: Estudo descritivo exploratório. A coleta de dados ocorreu em um hospital universitário em Maringá - PR, entre julho e outubro de 2009, com 37 trabalhadores obesos, que receberam oito sessões semanais de acupuntura. Para mensuração do apetite, foram utilizadas as Escalas Visuais Analógicas. RESULTADOS: Demonstraram que o comportamento do apetite em relação à saciedade, plenitude, desejo por alimentos doces e palatáveis sofreu modificações durante a intervenção. Não houve redução de peso ou índice de massa corpórea dos sujeitos, contudo observou-se redução significativa na razão cintura-quadril (p=0,02 e controle no hábito de consumir alimento consolo. CONCLUSÃO: Os achados do estudo podem contribuir para a formação do corpo de conhecimento da acupuntura voltada à saúde do trabalhador, sobretudo nos aspectos relacionados à obesidade, suas comorbidades e fatores desencadeantes.OBJETIVO: Mensurar el comportamiento de la sensación de apetito de los sujetos antes, durante y después de la intervención de acupuntura. MÉTODOS: se trata de un estudio descriptivo exploratorio. La recolección de datos se llevó a cabo en un hospital universitario en Maringá PR, entre julio y octubre del 2009, con 37 trabajadores obesos, que recibieron ocho sesiones semanales de acupuntura. Para la mensuración del apetito, fueron utilizadas las Escalas Visuales Analógicas. RESULTADOS: Demostraron que el comportamiento del apetito en relación a la saciedad, plenitud, deseo de alimentos dulces y agradables al paladar sufrió modificaciones durante la intervención. No hubo reducción de peso o índice de masa corporal de los sujetos, con todo se observó reducción significativa en la razón cintura-cadera (p=0,02 y control en el hábito de consumir alimento consuelo. CONCLUSIÓN: Los hallazgos del

  14. Aterosclerose subclínica e marcadores inflamatórios em crianças e adolescentes obesos e não obesos Atherosclerosis subclinical and inflammatory markers in obese and nonobese children and adolescents

    Directory of Open Access Journals (Sweden)

    Larissa R. Silva

    2012-12-01

    Full Text Available OBJETIVO: Realizou-se revisão sistemática sobre espessamento médio-intimal (EMI e marcadores inflamatórios, comparou-se EMI por metanálise e analisou-se a correlação entre EMI e variáveis inflamatórias em crianças e adolescentes obesos e não obesos. FONTES DOS DADOS: Buscaram-se artigos nas bases de dados Pubmed, Bireme e Science Direct, nos anos de 2000 a 2010, com as seguintes palavras-chave em inglês: "obesity", "adolescents", "atherosclerosis" e "child", sendo utilizados em duas combinações: obesity+adolescents+atherosclerosis e obesity+child+atherosclerosis. Utilizou-se meta-análise para comparar EMI entre obesos e não obesos. SINTESE DOS DADOS: Selecionou-se criteriosamente 16 artigos para análise final. Houve diferença da espessura de EMI entre obesos e não obesos em 12 estudos, confirmada pela meta-análise. Os obesos apresentaram concentrações de proteína C-reativa mais elevada em 13 artigos analisados (p We conducted a systematic review of intima-media thickness(IMT and inflammatory markers, compared IMT and identified by meta-analysis related to EMI and inflammatory variables in obese and non-obese children and adolescents. We searched for articles in databases Pubmed, Bireme and Science Direct, during years 2000 to 2010, with the following key words in English: "obesity", "adolescents", "atherosclerosis" and "child ", They were used in two combinations: obesity + adolescents + atherosclerosis + child + obesity and atherosclerosis. We used meta-analysis to compare IMT between obese and non-obese patients. We carefully selected 16 articles for final analysis. There were differences in the thickness of IMT between obese and non-obese patients in 12 studies, confirmed by meta-analysis. Obese patients had concentrations of C-reactive protein higher in 13 articles analyzed (p < 0.05 and lower adiponectin levels in 4 (p < 0.05. In general, obese men had lower concentrations of adiponectin and higher values of IMT and C

  15. Prevalencia de hiperlipidemia e hiperglicemia en niños obesos: ¿riesgo aumentado de enfermedad cardiovascular?

    Directory of Open Access Journals (Sweden)

    M. Marcano

    Full Text Available Las enfermedades cardiovasculares representan la primera causa de muerte en Venezuela desde el año 1967. Existen evidencias que demuestran que la lesión temprana de la aterosclerosis coronaria se inicia en la infancia con marcada asociación a la obesidad y diabetes, por lo que su prevención debe iniciarse en esa época. Objetivo: Estudiar la presencia de hiperlipidemia e hiperglicemia en niños obesos como indicadores de riesgo. Metodología: Se seleccionaron 121 niños (edad 8,7±3,43 años, con índice de masa corporal mayor al P90 para su edad (Fundacredesa. Se determinó colesterol sérico total y fracciones (HDL-C y LDL-C, triglicéridos y glicemia en ayunas por métodos enzimáticos-colorimétricos.Se utilizaron puntos de corte para colesterol y triglicéridos según referencia nacional (Fundacredesa, para las LDL-C y HDL-C, los criterios del National Cholesterol Education Program y para glicemia según la American Diabetes Association. La muestra se agrupó por edad en: 2-5,11 años (19%: Grupo 1; 6-8,11 años (28,1%: Grupo 2 y mayores de 9 años (52,9%: Grupo 3. Análisis estadístico por genero y grupo etario. Resultados: El colesterol se ubicó en "riesgo" en los varones Grupo 1. Las HDL-C en riesgo en las niñas de Grupo 1 y Grupo 3 y en los varones Grupo 3. Los triglicéridos, se ubicaron en niveles de "riesgo" para las niñas Grupo 1 y Grupo 3 y varones Grupo 2 y en rango "elevado" en los varones Grupo 1 y Grupo 3. Las LDL-C, se ubicaron en todos los grupos en rango "aceptable" y no se encontró hiperglicemia en los niños evaluados. Conclusión: El perfil bajo de HDL y elevado de triglicéridos, sugiere un mayor riesgo de estos niños obesos a enfermedad cardiovascular, con mayor afectación en el género masculino. Una elevada proporción de ellos cumple con tres criterios definitorios de Síndrome metabólico por lo que se recomienda control dietario y modificaciones en el patrón de alimentación y de actividad física.

  16. Problemas clínicos pré-anestésicos de pacientes morbidamente obesos submetidos a cirurgias bariátricas: comparação com pacientes não obesos Problemas clínicos pré-anestésicos de pacientes mórbidamente obesos sometidos a cirugías bariátricas: comparación con pacientes no obesos Preanesthetic clinical problems of morbidly obese patients submitted to bariatric surgery: comparison with non-obese patiens

    OpenAIRE

    2002-01-01

    JUSTIFICATIVA E OBJETIVOS: A obesidade mórbida associa-se a problemas clínicos, responsáveis por diminuição da expectativa de vida. Pacientes obesos mórbidos são candidatos a cirurgias bariátricas, impondo novos desafios ao anestesiologista. Este estudo comparou a prevalência de problemas clínicos entre pacientes morbidamente obesos submetidos a cirurgias bariátricas e não obesos submetidos a outros procedimentos eletivos. MÉTODO: Foram estudados, retrospectivamente, os registros eletrônicos ...

  17. Métodos de análise da composição corporal em adultos obesos

    Directory of Open Access Journals (Sweden)

    Rávila Graziany Machado de Souza

    2014-10-01

    Full Text Available Os métodos de avaliação da composição corporal em obesos têm sido amplamente discutidos, uma vez que nesses indivíduos a avaliação é dificultada devido às limitações dos equipamentos e características dos métodos utilizados. Esta sessão temática tem o objetivo de esclarecer as características, vantagens e limitações dos métodos de avaliação da composição corporal em adultos obesos. A quantificação de gordura corporal e mas-sa livre de gordura, assim como a avaliação da perda de massa muscular e de massa óssea em obesos são temas de grande interesse científico, uma vez que são utilizados para diagnosticar a obesidade osteosarcopênica. A avaliação da composição corporal de obesos pelo modelo de múltiplos compartimentos é padrão-ouro na prática científica. Por outro lado, o método de absorciometria radiológica de feixe duplo é considerado o padrão de referência em pesquisas e na prática clínica. Estudos indicam que a ressonância magnética e a tomografia computadorizada, em alguns casos, são fortemente correlacionadas com a absorciometria radiológica de feixe duplo. Os demais métodos apresentam limitações em avaliar a composição corporal, bem como suas modificações durante a redução ponderal em indivíduos obesos.

  18. Aleitamento materno exclusivo atenua riscos cardiovasculares e estado inflamatório em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Deborah Cristina Landi MASQUIO

    2014-01-01

    Full Text Available Objetivo: Verificar o perfil inflamatório e o risco de doenças das artérias carótidas em adolescentes obesos de acordo com tempo de aleitamento materno exclusivo na infância, Métodos: Trata-se de estudo transversal realizado com 118 adolescentes obesos, A duração do aleitamento materno exclusivo foi obtida por meio de entrevista com os pais, A espessura da íntima-média da artéria carótida (EIMc foi estimada por ultrassonografia, Massa corporal, Índice de Massa Corporal (IMC, Circunferência da Cintura (CC e pressão arterial foram mensurados, Dosagens séricas de glicose, insulina, colesterol total, LDL, adiponectina e leptina foram realizadas, A resistência insulínica foi determinada por meio do Homeostasis Model Assessment Insulin Resistance (HOMA-IR, Resultados: Adiponectina apresentou-se significativamente superior em adolescentes amamentados exclusivamente até os 6 meses, Por outro lado, a EIMc mostrou-se significativamente inferior nesses adolescentes, Massa corporal, IMC, gordura corporal, CC, insulina e HOMA-IR apresentaram-se significativamente inferiores em adolescentes que receberam aleitamento materno exclusivo até os seis meses comparados aos que não receberam, Insulina e HOMA-IR associaram-se com a massa corporal, IMC, CC e gordura corporal, As concentrações de leptina associaram-se negativamente com adiponectina e positivamente com gordura corporal e IMC, Pressão arterial sistólica e diastólica foram preditas positivamente pela massa corporal, IMC e CC, Conclusão: Adolescentes obesos amamentados exclusivamente por 6 meses apresentam um perfil antropométrico e metabólico e estado inflamatório mais atenuado, bem como menores riscos cardiovasculares, o que pode contribuir para redução de riscos de desenvolvimento de aterosclerose em longo prazo.

  19. Percepção do adolescente obeso sobre as repercussões da obesidade em sua saúde Percepción de los adolescentes obesos respecto de los efectos de la obesidad en su salud Obese adolescents' perceptions about the repercussions of obesity on their health

    Directory of Open Access Journals (Sweden)

    Solange Queiroga Serrano

    2010-03-01

    Full Text Available O objetivo deste estudo é avaliar a percepção do adolescente obeso sobre as repercussões da obesidade em sua saúde. Baseou-se no relato de quinze adolescentes obesos, acompanhados no Ambulatório do Hospital das Clínicas da Universidade Federal de Pernambuco, no período de abril a julho de 2007. Os depoimentos, obtidos através de entrevista semi-estruturada, foram submetidos à análise de conteúdo, modalidade temática transversal. Foram identificadas quatro temáticas relacionadas com os objetivos do estudo: 1. A percepção do conceito de obesidade; 2. A obesidade afetando a auto-imagem; 3. Obesidade versus Saúde e 4. O difícil retorno à saúde. Os adolescentes perceberam a obesidade como doença, repercutindo negativamente sobre sua saúde, apresentando uma baixa auto-estima e a sensação de isolamento. Reconhecem que ser saudável é ter uma alimentação correta e praticar atividade física, sendo imprescindível o apoio formal e informal, sobrepujando as dificuldades para manter uma qualidade de vida satisfatória.El objetivo de este estudio es evaluar la percepción del adolescente obeso respecto de los efectos de la obesidad en su salud. Se basó en el relato de quince adolescentes obesos que recibían seguimiento médico en el Ambulatorio del Hospital das Clínicas da Universidade Federal de Pernambuco, utilizándose el método de entrevista semiestructurada, en el período de abril a julio de 2007. Los testimonios obtenidos de las grabaciones transcriptas fueron sometidos al método de análisis de contenido, modalidad temática transversal. Se identificaron cuatro temáticas relacionadas con los objetivos del estudio: 1. La percepción del concepto de obesidad, 2. La obesidad afectando la autoimagen, 3. Obesidad versus salud, y 4. El difícil retorno a la salud. Los adolescentes reconocieron a la obesidad como una enfermedad que acarrea repercusiones negativas en su salud, generándoles una baja autoestima y sensaci

  20. Modelo educativo nutricional para la reducción de factores de riesgo cardiovascular en niños escolares obesos

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    María del Pilar Suárez de Ronderos

    2003-07-01

    Full Text Available El objetivo de esta investigación fue evaluar la efectividad de un modelo de educación nutricional para la reducción de factores de riesgo de enfermedad cardiovascular en niños escolares obesos. Se realizó un diagnóstico previo para identificar las características generales de este grupo de niños y determinar el estado nutricional, los conocimientos, las actitudes y las prácticas alimentarlas relacionadas con factores de riesgo cardiovascular. El estudio de tipo casi experimental incluyó 31 niños obesos divididos en dos grupos: 15 casos y 16 controles. Todos los niños tenían entre 7 y 12 años, con obesidad, y remitidos por médicos de la consulta externa del Hospital Nacional de Niños. En los casos se implementó el modelo educativo, el cual contempló la participación de padres y niños con metodología participativa diseñada para niños en edad escolar. El modelo incluye 5 sesiones educativas en las que se utiliza un libro de actividades, cuentos y juegos. Los resultados de la intervención fueron evaluados tres meses después de la intervención educativa. Los resultados muestran que la mayoría de los niños presentaron antecedentes de Diabetes Mellitus, bajos niveles socioeconómicos, sedentarismo, así como dislipidemia el 97%. El 97% de los niños evaluados presenta al menos 2 factores de riesgo de enfermedad cardiovascular. El análisis de la dieta reportó disgusto por el consumo de frutas y vegetales e inadecuado consumo de macronutrientes y micronutrientes. También se identificaron inadecuados conocimientos relacionados con la alimentación adecuada para la prevención de enfermedad cardiovascular, así como trastornos de baja autoestima. El modelo educativo elaborado fue efectivo en el grupo intervenido, al mostrar cambios significativos las variables analizadas.

  1. Educação para a saúde a grupo de obesos

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    Glaci de Oliveira Pinto Vargas

    1983-03-01

    Full Text Available Este trabalho foi realizado por enfermeiras que atuam a nível ambulatorial, num Programa de Adulto, no Serviço de Saúde Pública, de um hospital geral de Porto Alegre, RS. É uma contribuição original de uma pesquisa descritivo analítica, com grupos de clientes obesos, atendidos através de cursos de educação para a saúde. Pretende-se avaliar quatro aspectos sem ordem de prioridade: a interesse da clientela pela educação da saúde, em grupo; b impressão, em relação aso conteúdos desenvolvidos; c redução do peso; d mudança de algum hábito de vida.

  2. Temperamento emocional e afetivo em pacientes obesos tabagistas candidatos a cirurgia bariátrica

    OpenAIRE

    2013-01-01

    INTRODUÇÃO: Estimativas de prevalência de tabagismo em obesos mórbidos tem sido maiores que na população em geral. Existem algumas evidências de que tabagistas possuem temperamentos distintos de não tabagistas. OBJETIVO: Avaliar a ocorrência de dimensões de temperamentos na população que se candidata a realização de cirurgia bariátrica e verificar se há diferenças entre fumantes, exfumantes e não fumantes. MÉTODOS: Foram analisados dados sobre o temperamento afetivo e emocional através da esc...

  3. Percepción de la propia imagen corporal en pacientes obesos o con sobrepeso.

    Directory of Open Access Journals (Sweden)

    Faustino Abad Massanet

    2012-08-01

    Full Text Available La obesidad es un importante problema de salud en la comunidad, y su abordaje es complejo. La valoración de la propia imagen corporal podría ser de ayuda, en pacientes obesos o con sobrepeso, para orientar hacia la obtención de un peso más saludable. Con este objetivo se utilizó una escala de figuras (escala de Stunkard en pacientes de estas características, comparando la figura seleccionada por cada participante con la correspondiente a su Índice de Masa Corporal real. La concordancia entre ambas fue escasa, con marcado predominio de sujetos que infravaloran su IMC. El error en la valoración fue significativamente mayor entre las mujeres, en los participantes con menor nivel de estudios, y entre los que presentaban algún componente del síndrome metabólico.

  4. Quality of life and sleep in obese adolescents Qualidade de vida e do sono de adolescentes obesos

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    Giovina Turco

    2013-02-01

    Full Text Available Obesity and sleep disorders in adolescence are strongly associated, and they impact both on the health and on quality of life (QL in this age group. OBJECTIVE: To comparatively assess QL and sleep in obese and eutrophic adolescents, who are older than ten years of age. METHODS: Cross-sectional study including obese adolescents. This analysis was carried out between August 2009 and August 2010. The Control (eutrophic Group comprised schoolchildren recruited from State schools in the city of Americana, in São Paulo State, Brazil. Instruments applied included a standardized questionnaire, the Sleep Behavior Questionnaire (SBQ, and the Pediatric QL Inventory (PedsQL TM 4.0. RESULTS: The obese adolescents had poorer QL on physical (pObesidade e distúrbios do sono na adolescência estão amplamente associados, afetando a saúde e a qualidade de vida (QV de tal grupo etário. OBJETIVO: Foi avaliar comparando a QV e o sono em adolescentes obesos e eutróficos maiores de dez anos. MÉTODOS: Estudo transversal realizado entre agosto de 2009 e agosto de 2010, com adolescentes obesos. O Grupo Controle (eutróficos foi constituído por estudantes da rede pública de ensino da cidade de Americana, em São Paulo. Foram utilizados ficha de identificação, Questionário do Comportamento do Sono (SBQ, Questionário de QV (PedsQL TM 4.0 como instrumentos. RESULTADOS: Os adolescentes obesos apresentaram QV inferior à dos controles nos domínios físico (p<0,001, emocional (p=0,03 e social (p=0,002. Houve diferença em relação à avaliação psicossocial entre obesos e eutróficos (médias de 69,5±16,0 e 76,2±16,7, respectivamente. O grupo de adolescentes obesos apresentou maior quantidade de distúrbios do sono (p=0,03. Conclusões: Adolescentes obesos apresentaram prejuízo na QV e maior quantidade de distúrbios do sono comparados aos indivíduos eutróficos.

  5. Quality of life and sleep in obese adolescents Qualidade de vida e do sono de adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Giovina Turco

    2013-01-01

    Full Text Available Obesity and sleep disorders in adolescence are strongly associated, and they impact both on the health and on quality of life (QL in this age group. OBJECTIVE: To comparatively assess QL and sleep in obese and eutrophic adolescents, who are older than ten years of age. METHODS: Cross-sectional study including obese adolescents. This analysis was carried out between August 2009 and August 2010. The Control (eutrophic Group comprised schoolchildren recruited from State schools in the city of Americana, in São Paulo State, Brazil. Instruments applied included a standardized questionnaire, the Sleep Behavior Questionnaire (SBQ, and the Pediatric QL Inventory (PedsQL TM 4.0. RESULTS: The obese adolescents had poorer QL on physical (pObesidade e distúrbios do sono na adolescência estão amplamente associados, afetando a saúde e a qualidade de vida (QV de tal grupo etário. OBJETIVO: Foi avaliar comparando a QV e o sono em adolescentes obesos e eutróficos maiores de dez anos. MÉTODOS: Estudo transversal realizado entre agosto de 2009 e agosto de 2010, com adolescentes obesos. O Grupo Controle (eutróficos foi constituído por estudantes da rede pública de ensino da cidade de Americana, em São Paulo. Foram utilizados ficha de identificação, Questionário do Comportamento do Sono (SBQ, Questionário de QV (PedsQL TM 4.0 como instrumentos. RESULTADOS: Os adolescentes obesos apresentaram QV inferior à dos controles nos domínios físico (p<0,001, emocional (p=0,03 e social (p=0,002. Houve diferença em relação à avaliação psicossocial entre obesos e eutróficos (médias de 69,5±16,0 e 76,2±16,7, respectivamente. O grupo de adolescentes obesos apresentou maior quantidade de distúrbios do sono (p=0,03. Conclusões: Adolescentes obesos apresentaram prejuízo na QV e maior quantidade de distúrbios do sono comparados aos indivíduos eutróficos.

  6. Impacto del ejercicio de fuerza muscular en la prevención secundaria de la obesidad infantil: intervención al interior del sistema escolar

    OpenAIRE

    Fabián Vásquez; Erik Díaz; Lydia Lera; Jorge Meza; Isabel Salas; Pamela Rojas; Eduardo Atalah; Raquel Burrows

    2013-01-01

    Introducción: El ejercicio físico es una importante herramienta terapéutica para prevenir y tratar la obesidad y disminuir las alteraciones metabólicas asociadas al desarrollo de las enfermedades crónicas no transmisibles. Objetivo: Evaluar el impacto de una intervención al interior del sistema escolar, que incluye el ejercicio de fuerza muscular, educación alimentaria y apoyo psicológico en escolares obesos. Métodos: Se trabajó con 120 escolares obesos, entre 8 y 13 años, reclutados en 3 col...

  7. Índice glicêmico e carga glicêmica de dietas consumidas por indivíduos obesos

    OpenAIRE

    SAMPAIO,Helena Alves de Carvalho; Silva,Bruna Yhang da Costa; SABRY Maria Olganê Dantas; Almeida,Paulo César de

    2007-01-01

    OBJETIVO: Avaliar o índice glicêmico e a carga glicêmica de dietas de indivíduos obesos. MÉTODOS: Trata-se de estudo retrospectivo, que analisou as fichas clínicas de 80 adultos obesos, acompanhados em um serviço privado localizado em Fortaleza, Ceará. Determinaram-se o índice glicêmico e a carga glicêmica da dieta. Para verificação da associação entre índice glicêmico e carga glicêmica, e dessas variáveis com a ingestão energética diária e com o índice de massa corporal dos indivíduos, utili...

  8. Avaliação do broncoespasmo induzido pelo exercício avaliado pelo Peak Flow Meter em adolescentes obesos

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    Luciana Oliveira e Silva

    2011-12-01

    Full Text Available INTRODUÇÃO: Crianças e adolescentes com excesso de peso apresentam maior prevalência de broncoespasmo induzido pelo exercício (BIE, quando comparados a eutróficos. A espirometria e o peak flow meter são importantes métodos avaliativos da função pulmonar. Porém, a aplicabilidade do medidor do pico de fluxo expiratório (peak flow meter na detecção do BIE em crianças e adolescentes com excesso de peso não é conhecida, o que justifica o desenvolvimento desta pesquisa. OBJETIVOS: Avaliar e comparar o desencadeamento de broncoespasmo induzido pelo exercício (BIE em crianças e adolescentes não asmáticos com excesso de peso, avaliados pela espirometria e pelo peak flow meter (PFE. CASUÍSTICA E MÉTODOS: Participaram do estudo 39 voluntários acima do percentil 85º (OB e 30 eutróficos (EU, de oito a 15 anos. A avaliação da função pulmonar pré e pós-teste de broncoprovocação foi realizada pela espirometria e peak flow meter, de acordo com o protocolo de Del Río-Navarro et al., (2000. O BIE foi considerado positivo quando o voluntário apresentou uma redução > 10% do VEF1 basal ou redução > 20% do PFE PFM e/ou PFE E. RESULTADOS: Na detecção do BIE, a prevalência do grupo obeso foi de 26% avaliado pelo peak flow meter (PFEPFM e 23% pelo VEF1. O tempo do BIE ocorreu nos primeiros 15 minutos pós-exercício em ambos os parâmetros: (PFE PFM e VEF1. CONCLUSÃO: Os voluntários obesos apresentaram tempo e prevalências similares de BIE, quando avaliados por ambos os métodos de avaliação pulmonar. O fácil manejo e o baixo custo facilitam a maior acessibilidade para a população geral do peak flow meter, o que demonstra sua importância como parte integrante de um programa educacional no diagnóstico inicial do BIE em vias aéreas de grande calibre.

  9. Microbial degradation of monocyclic and polycyclic aromatic hydrocarbons in case of limited pollutant availability with nitrate as a potential electron acceptor; Der mikrobielle Abbau mono- und polyzyklischer aromatischer Kohlenwasserstoffe bei einer begrenzten Schadstoffverfuegbarkeit mit Nitrat als potentiellem Elektronenakzeptor

    Energy Technology Data Exchange (ETDEWEB)

    Linke, C.

    2001-07-01

    The possibility of using natural degradation processes for long-term remediation of tar oil contaminated sites was investigated. Field studies have shown that microbial decomposition of pollutants does take place in many sites but that it is limited by limited availability of pollutants and oxygen in soil. The investigations focused on the activation of BTEX and PAH degradation in situ by nitrate in the absence or in the presence of oxygen. Tensides should be used in order to enhance the availability of pollutants in water, especially in the case of hardly water-soluble PAH. A large-scale experiment was carried out on tar oil contaminated terrain; it was found that the availability of oxygen and not of PAH is the limiting factor so that adding of surfactants will not improve pollutant degradation. In contrast, the adding of tensides would mean even higher concentrations of oxygen-depleting substances in soil. [German] In der vorliegenden Arbeit wurden im Hinblick auf langfristige Sanierungsstrategien fuer teeroelkontaminierte Standorte Moeglichkeiten der Nutzung natuerlicher Abbauvorgaenge untersucht. Zahlreiche Feldstudien belegen, dass ein mikrobieller Schadstoffabbau an vielen Standorten stattfindet, dieser jedoch sowohl durch eine begrenzte Schadstoffverfuegbarkeit als auch durch den im Untergrund nur begrenzt zur Verfuegung stehenden Sauerstoff limitiert wird. Ziel dieser Arbeit war es abzuklaeren, inwiefern ein BTEX- und PAK-Abbau in situ auch in Abwesenheit von Sauerstoff durch Nitrat allein oder durch Nitrat in Kombination mit Sauerstoff aktiviert werden kann. Um insbesondere fuer die schlecht wasserloeslichen PAK eine ausreichende Schadstoffverfuegbarkeit zu gewaehrleisten, sollten auch Tenside zur Erhoehung der im Wasser vorliegenden Schadstoffmenge eingesetzt werden. Aufbauend auf die Laboruntersuchungen wurde im Rahmen von VEGAS{sup ix} ein Grossversuch zum mikrobiellen PAK-Abbau im Abstrom einer simulierten Teeroelkontamination durchgefuehrt

  10. Influencia do indice de massa corporal no equilibrio e na configuracao plantar em obesos adultos

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    Liu Chiao Yi

    2014-01-01

    Full Text Available INTRODUÇÃO: A obesidade é uma doença crônica degenerativa multifatorial que pode levar a alterações do sistema musculoesquelético, como mudança do centro de gravidade e sobrecarga mecânica sobre os membros inferiores. OBJETIVOS: Correlacionar o índice de massa corporal (IMC com o equilíbrio corporal e verificar associação entre o IMC e a configuração plantar. MÉTODOS: Foram avaliados 30 obesos, de ambos os gêneros, com IMC maior ou igual a 30 Kg/m². Inicialmente, os voluntários foram submetidos às avaliações de medidas antropométricas a fim de calcular o valor do IMC. Em seguida, foram submetidos ao teste de equilíbrio corporal estático Balance Error Scoring System (BESS e a plantigrafia para a identificação da impressão plantar. Por meio do método de Viladot, os voluntários foram classificados em grupos: pé plano (GPP, pé cavo (GPC e pé neutro (GPN. A correlação entre as variáveis IMC e BESS foi calculada por meio do coeficiente de correlação linear de Pearson e associação entre o IMC e a configuração plantar foi realizada por meio da análise de variância (Anova. Para todas as análises, nível de significância considerado foi p < 0,05. RESULTADOS: Os valores da correlação entre o IMC e o BESS foram r = - 0,1 e p = 0,59. Os valores da associação do IMC entre GPN - GPP; GPN - GPC; GPP - GPC foram respectivamente: p = 0,76; p = 0,001; p = 0,07. CONCLUSÃO: O índice de massa corporal de adultos obesos não influencia o equilíbrio corporal, porém influencia na configuração plantar.

  11. Características miofuncionais e eletromiográficas de crianças e adolescentes obesos

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    Denise Bolzan Berlese

    2013-08-01

    Full Text Available OBJETIVO: investigar as características miofuncionais e eletromiográficas de obesos em relação ao sexo e faixa de idade. MÉTODO: amostra de conveniência de 28 crianças e adolescentes obesos, de ambos os sexos, participantes do grupo de Obesidade do Ambulatório de Pediatria do Hospital Universitário do Hospital Universitário de Santa Maria, no período de janeiro a julho de 2011. As características Miofuncionais foram realizadas por fonoaudióloga experiente por meio do Protocolo de Avaliação Miofuncional com Escores (AMIOFE. A avaliação eletromiografica dos músculos masseter e temporal foi obtida utilizando o Eletromiógrafo Lynx e realizada três coletas para cada uma das situações (repouso, mastigação, deglutição e máxima intercuspidação. Os dados eletromiográficos foram normalizados, expressos em percentual, utilizando-se a média da máxima intercuspidação de cada músculo estudado nas avaliações realizadas. RESULTADOS: a maioria dos obesos desta pesquisa apresentaram características miofuncionais dentro da normalidade, não sendo observada diferença estatística significante quando comparados por sexo e idade. Embora a média normalizada da atividade elétrica dos músculos masseter e temporais durante o repouso, mastigação e deglutição dos obesos de acordo com sexo e idade não apresentaram diferença estatística significante, observa-se uma maior ativação dos músculos masseter do que os músculos temporais. CONCLUSÕES: pode-se concluir que crianças e adolescentes obesos, de ambos os sexo têm características miofuncionais dentro da normalidade e que há uma maior ativação dos músculos masseteres para a função da mastigação e deglutição do que os músculos temporais.

  12. 40 CFR 721.2140 - Carbo-poly-cycli-col azo-alkyl-aminoalkyl-carbo-mono-cyclic ester, halogen acid salt.

    Science.gov (United States)

    2010-07-01

    ...-aminoalkyl-carbo-mono-cyclic ester, halogen acid salt. 721.2140 Section 721.2140 Protection of Environment...-aminoalkyl-carbo-mono-cyclic ester, halogen acid salt. (a) Chemical substance and significant new uses...-mino-al-kyl-car-bo-mon-o-cyc-lic ester, halogen acid salt (PMN P-88-1682) is subject to reporting...

  13. Resonant mono Higgs at the LHC

    CERN Document Server

    Basso, Lorenzo

    2015-01-01

    In recent years, the production of a SM particle with large missing transverse momentum, dubbed mono-X searches, have gained increasing attention. After the discovery of the Higgs boson in 2012, the run-II of the LHC will now scrutinise its properties, looking for BSM physics. In particular, one could search for mono-Higgs signals, that are typically studied in models addressing dark matter. However, this signal can appear also in models addressing the neutrino masses, if additional heavier neutrinos with masses at the electroweak scale are present. The latter will couple to the SM neutrinos and the Higgs boson, yielding a type of mono-Higgs signal not considered for dark matter: the resonant production of a Higgs boson and missing energy. In this paper, we address the LHC exclusion power of the latter with dedicated detector simulations, and reinterpret it in a benchmark model for neutrino mass generation.

  14. Efeitos de diferentes graus de sensibilidade a insulina na função endotelial de pacientes obesos Efectos de diferentes grados de sensibilidad a la insulina en la función endotelial de pacientes obesos Effects of different degrees of insulin sensitivity on endothelial function in obese patients

    Directory of Open Access Journals (Sweden)

    Roberto Galvão

    2012-01-01

    Full Text Available FUNDAMENTO: A obesidade derivada da deposição de gordura intra-abdominal tende a aumentar a produção de hormônios e citoquinas, piorando a sensibilidade a insulina e levando a disfunção endotelial. A hiperinsulinemia é considerada um fator de risco independente para doença isquêmica cardíaca e é uma causa de disfunção endotelial em indivíduos saudáveis. OBJETIVO: Avaliar o impacto de diferentes graus de resistência a insulina, medida pelo HOMA-IR (Homeostasis Model Assessment of Insulin Resistance, sobre a função endotelial de obesos, pacientes não diabéticos, sem história prévia de eventos cardiovasculares e diversos componentes da síndrome metabólica. MÉTODOS: Um total de 40 indivíduos obesos foi submetido a medidas antropométricas, pressão arterial de consultório, MAPA e exames laboratoriais, além de avaliação ultrassonográfica não invasiva da função endotelial. Os pacientes foram divididos em três grupos de acordo com o grau de resistência a insulina: pacientes com valores de HOMA-IR entre 0,590 e 1,082 foram incluídos no Grupo 1 (n = 13; entre 1,083 e 1,410 no Grupo 2 (n = 14; e entre 1,610 e 2,510 no Grupo 3 (n = 13. RESULTADOS: Encontramos uma diferença significativa na vasodilatação mediada por fluxo no Grupo 3 em relação ao Grupo 1 (9,2 ± 7,0 vs 18,0 ± 7,5 %, p = 0,006. Houve uma correlação negativa entre a função endotelial e insulina, HOMA-IR e triglicérides. CONCLUSÃO: Nosso estudo sugere que leves alterações nos níveis de resistência a insulina avaliada pelo HOMA-IR podem causar algum impacto sobre a função vasodilatadora do endotélio em indivíduos obesos não complicados com diferentes fatores de risco cardiovascular.FUNDAMENTO: La obesidad derivada del depósito de grasa intraabdominal tiende a aumentar la producción de hormonas y citocinas, empeorando la sensibilidad a la insulina y llevando a disfunción endotelial. La hiperinsulinemia es considerada un factor de

  15. Prevalência e gravidade de asma brônquica em adultos obesos com indicação de cirurgia bariátrica

    OpenAIRE

    Melo,Saulo Maia Davila; Melo,Valdinaldo Aragão de; Menezes Filho,Raimundo Sotero; Alves Júnior,Antônio J

    2011-01-01

    OBJETIVO: Determinar a prevalência de asma em um grupo de adultos obesos, candidatos a cirurgia bariátrica e avaliar a gravidade da asma neste grupo de pacientes. MÉTODOS: Estudo transversal, envolvendo 363 pacientes obesos adultos (índice de massa corpórea > 35 kg/m²) avaliados por um médico pneumologista, utilizando a avaliação clínica como instrumento diagnóstico de asma. Todos os pacientes foram submetidos à avaliação clínica e espirometria e foram divididos em dois grupos (asma e control...

  16. Limiar de variabilidade da freqüência cardíaca em adolecentes obesos e não-obesos Heart rate variability threshold in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Antônio Fernando Brunetto

    2008-04-01

    Full Text Available A obesidade na adolescência está associada à disfunção simpato-vagal cardíaca em repouso, embora existam poucas informações sobre a resposta autonômica durante o exercício nestes adolescentes. OBJETIVO: Comparar a modulação autonômica durante teste de esforço físico dinâmico incremental em amostras de adolescentes obesos e não-obesos, e analisar a relação entre o limiar de variabilidade da freqüência cardíaca (LiVFC e o limar ventilatório (LV. MÉTODOS: Dez adolescentes obesos e 19 adolescentes não-obesos do sexo masculino com idades entre 13 e 18 anos foram submetidos à teste de esforço físico progressivo máximo em esteira rolante para estudo da variabilidade da freqüência cardíaca (VFC e para identificação do LV. A VFC foi estudada mediante análise do desvio-padrão da variabilidade instantânea batimento-a-batimento (SD1 da Plotagem de Poincaré. O LiVFC foi identificado na intensidade de esforço físico em que o SD1 atingiu valor menor que 3 ms. RESULTADOS: O índice SD1 diminuiu progressivamente em ambos os grupos até aproximadamente 50-60% do VO2pico, sendo que os adolescentes obesos apresentaram valores significativamente menores (pObesity in adolescence is associated with a cardiac sympathetic-parasympathetic dysfunction at rest. However, there is little information about the autonomic response during exercise in these adolescents. OBJECTIVE: To compare the cardiac autonomic modulation during a maximal exercise test in obese and non-obese adolescents and analyze the association between the Heart Rate Variability threshold (HRVT and the Ventilatory threshold (VT. METHODS: Ten obese and 19 non-obese male adolescents with age between 13-18 years were submitted to a maximal progressive treadmill physical exercise test for Heart Rate Variability (HRV study and VT determination. HRV was assessed through the study of Poincaré Plot, by the analysis of the standard deviation of instantaneous beat

  17. Search for Exotic mono-jet and mono-photon signatures with the ATLAS detector

    Directory of Open Access Journals (Sweden)

    Rezvani Reyhaneh

    2013-05-01

    Full Text Available Mono-jet and mono-photon signatures are final states in a variety of scenarios beyond the Standard Model, such as the Large Extra Dimension models, gauge-mediated SUSY breaking scenarios, and models with pair production of Weakly Interacting Massive Particles considered as dark matter candidates. The produced exotic particles do not interact with the detector, resulting in missing transverse energy. The results of searches, performed in the ATLAS experiment at the LHC, for new physics in final states with an energetic jet or photon and large missing transverse energy are presented. The mono-jet search is performed using both 4.6 fb−1 of 7 TeV and 10.5 fb−1 of 8 TeV data, while the mono-photon results correspond to 4.6 fb−1 of 7 TeV data.

  18. Motivação à prática regular de atividades físicas e esportivas: um estudo comparativo entre estudantes com sobrepeso, obesos e eutróficos Motivation of regular physical and sporting activities practice: a comparative study between obeses, overweight, and other students

    Directory of Open Access Journals (Sweden)

    Marcos Alencar Abaide Balbinotti

    2011-09-01

    Full Text Available O principal objetivo do presente estudo é comparar os níveis de motivação à prática regular de atividades físicas de três diferentes grupos de alunos das escolas de ensino fundamental e médio do município de Erechim/RS: Obesos, com sobrepeso, e eutróficos. Para tanto, além das avaliações antropométricas - massa corporal e altura - foi aplicado o Inventário de motivação à prática regular de atividades físicas e esportivas (IMPRAFE-54 ( BALBINOTTI; BARBOSA, 2006 . Os resultados variaram consideravelmente em valores nominais e a principais dimensões motivacionais foram as seguintes: Obesos (saúde; sobrepeso (estética; saúde; prazer; eutróficos (saúde, estética, prazer. Na comparação inter-grupo (obesos; sobrepeso; eutróficos, a dimensão Estética se destacou na diferença entre os grupos de sobrepesos e obesos. Espera-se que esses resultados possam contribuir para a prática pedagógica da educação física escolar.The main intent of the present study is compare the motivation levels of regular physical activities practice of three differents scholars groups from elementary and middle schools of Erechim/RS municipal district: Obeses, overweight, and Eutrophic. Then, besides the anthropometry evaluations - corporal mass and height - was applied the "Inventário de motivação à prática regular de atividades físicas e esportivas" (IMPRAFE-54 ( BALBINOTTI; BARBOSA, 2006 . The results varied considerably in nominal values and the main motivation dimensions were as follows: Obeses (health; overweight (esthetics; health; joy; Eutrophic (health; esthetics; joy. In comparing inter-group (obese, overweight, Eutrophic, the Aesthetic dimension stood out in the difference between the groups of overweight and obese. Hope these results might contribute for the pedagogy practice in scholar physical education.

  19. 21 CFR 172.834 - Ethoxylated mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... ethoxylated mono-and diglycerides (polyoxyethylene (20) mono- and diglycerides of fatty acids) (polyglycerate... labeling it shall be followed by either “polyoxyethylene (20) mono-and diglycerides of fatty acids” or... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD...

  20. Group dialectical behavior therapy adapted for obese emotional eaters: a pilot study Terapia dialéctico-compartimental grupal adaptada para el tratamiento "comedores emocionales" obesos: un estudio piloto

    Directory of Open Access Journals (Sweden)

    M. A. Roosen

    2012-08-01

    Full Text Available Dialectical Behavior Therapy (DBT has been shown to effectively target binge eating disorder (BED. This study pilots the effectiveness of group DBT for obese "emotional eaters" to reduce eating psychopathology and achieve weight maintenance. Thirty-five obese male and female emotional eaters receiving 20 group psychotherapy sessions of DBT adapted for emotional eating were assessed at end-of-treatment and 6 month follow-up for reductions in eating psychopathology and weight maintenance. DBT resulted in significant reductions in emotional eating and other markers of eating psychopathology at the end-of-treatment that were maintained at follow-up. The drop-out rate was very low, with only 1 participant dropping from treatment. Thirty-three (94% of the sample provided data at every assessment point. Of these, 80% achieved either weight reduction or weight maintenance after treatment and throughout the follow-up period. The effect size for weight reduction was small. This pilot study demonstrates group DBT targeting emotional eating in the obese to be a highly acceptable and effective intervention for reducing eating related psychopathology at both at end-of-treatment and during follow-up. The ability of DBT to limit the upward trajectory of weight gain in obese patients with high degrees of emotional eating suggests that DBT may also help limit the increase or even prevent onset of obesity related morbidity in these patients.La Terapia Dialéctico-Conductual (TDC es una terapia eficaz para el tratamiento del trastorno por atracón (TA. Este estudio piloto pretende estudiar la eficacia de la TDC grupal para la reducción de psicopatologia alimentaria y el logro el mantenimiento del peso, para obesos "comedores emocionales". Treinta y cinco obesos "comedores emocionales" de ambos sexos fueron evaluados al final del tratamiento y en seguimiento a los seis meses en psicopatología alimentaria y reducción de peso tras recibir 20 sesiones de TDC en

  1. Efectos de un programa de ejercicio físico estructurado sobre los niveles de condición física y el estado nutricional de obesos mórbidos y obesos con comorbilidades

    Directory of Open Access Journals (Sweden)

    Pedro Delgado Floody

    Full Text Available Introducción: el aumento de la condición física se asocia a una disminución de los factores de riesgo de enfermedad cardiovascular en población obeso mórbida. Objetivo: el propósito de esta investigación fue evaluar los efectos de un programa de ejercicio físico sobre el estado nutricional y la condición física de obesos y obesos mórbidos candidatos a cirugía bariátrica. Material y métodos: 18 mujeres y 4 hombres entre 18 y 60 años candidatos a cirugía bariátrica, 16 con obesidad mórbida y 6 con obesidad y comorbilidades, fueron sometidos a un programa de ejercicio físico, con apoyo nutricional y psicológico de 5 meses de duración (3 sesiones/semana. Antes y 72 h después de la última sesión se evaluaron: peso, índice de masa corporal (IMC, contorno de cintura (CC, presión arterial sistólica y diastólica, capacidad cardiorrespiratoria, capacidad bioenergética, fuerza dinámica máxima y fuerza de prensión de las manos. Resultados: el peso (p = 0,000, el IMC (p = 0,000 y el CC (p = 0,000 presentaron cambios significativos con la intervención. La presión arterial sistólica y diastólica no mejoraron significativamente (p > 0,05. La capacidad cardiorrespiratoria, la fuerza dinámica máxima, la fuerza de prensión de las manos y la capacidad bioenergética mejoraron sus niveles y alcanzaron significancia (p < 0,05. Conclusiones: la intervención fue factible de desarrollar, con alta adherencia; no presentó riesgo para la salud de los sujetos y aumentó su condición física significativamente. Además, por cada 1 kg de peso perdido existió una disminución aproximada de 0,5 mmHg en la presión arterial sistólica y de 1 cm en el contorno de cintura, mejorando las condiciones preoperatorias de los participantes.

  2. Características socioeconómicas, familiares y ambientales en niños obesos de la Parroquia Antimano - Caracas

    Directory of Open Access Journals (Sweden)

    William José González Cabriles

    2009-01-01

    Full Text Available El objetivo del Artículo es caracterizar a las familias de niños obesos con métodos cuantitativo y cualitativo a fin de facilitar la intervención. El estudio fue transversal descriptivo - retrospectivo de familias de niños obesos atendidos en CANIA (1997 - 2000, Antímano - Caracas. Se estudiaron los datos socioeconómicos de 295 familias, utilizándose la distribución de frecuencia y la media para analizarlos mediante el programa SPSS 9.0 y se evaluó la dinámica familiar en dos casos, aplicándose la entrevista en profundidad en el hogar. La mayoría de las familias con niños obesos son pobres (Línea de pobreza y Graffar modificado, presentan diferente tipología y composición; sus integrantes se relacionan más con el paciente obeso; generalmente las conforman padres obreros con nueve años de escolaridad; destinan 70% del presupuesto a la alimentación y ésta última es influenciada por el jefe de familia; su comportamiento alimentario reflejó aspectos culturales y económicos; conocen las causas e implicaciones de la obesidad pero no la aceptan como problema; priorizan en salud, solo cuando aparecen enfermedades crónicas no trasmisibles; consideran a los factores externos limitantes para el cumplimiento del tratamiento nutricional. Se concluye que el conocimiento de las características socioeconómicas, familiares y ambientales del niño obeso, potencia la atención social e integral.

  3. O efeito em curto prazo do bypass gástrico sobre pacientes obesos diabéticos

    Directory of Open Access Journals (Sweden)

    Aluisio Stoll

    2013-02-01

    Full Text Available OBJETIVO: estudar o efeito do bypass gástrico sobre a glicemia e o uso de medicação antidiabética em pacientes obesos portadores de diabetes. MÉTODOS: estudo de coorte retrospectivo com 44 pacientes obesos portadores de DM2, provenientes de 469 pacientes submetidos ao bypass gástrico no período de dezembro de 2001 a março de 2009. Os desfechos primários avaliados foram: glicemia em jejum e a necessidade de medicação antidiabética. RESULTADOS: a população foi composta de dez (22,7% homens e 34 (77,3% mulheres, com média de idade de 45,3 (±8,23 anos e índice de massa corporal de 40,9 (±5,03 kg/m². O tempo médio de evolução do DM2 foi 63,6 (±60,9 meses. Dos 40 pacientes que utilizavam medicação para controle do DM2, 20 (50% tiveram sua medicação suspensa na alta hospitalar e 13 (32,5% até nove meses depois. Em uma paciente não foi possível avaliar o uso de medicação, sendo essa a única exclusão. A insulina foi suspensa nos dez (100% pacientes que a utilizavam, sendo seis (60% na alta hospitalar. Houve redução (P<0,05 da glicemia em jejum, em todo o período estudado, em comparação com o valor pré-operatório, e foram atingidos valores inferiores a 100mg/dl no período de sete a nove meses. CONCLUSÃO: Pacientes obesos portadores de DM2, submetidos ao bypass gástrico, apresentaram melhora do controle glicêmico e redução do uso de hipoglicemiantes em curto prazo.

  4. Aptidão cardiorrespiratória, perfil lipídico e metabólico em adolescentes obesos e não-obesos Cardiorespiratory fitness, lipid and metabolic profile in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Neiva Leite

    2009-09-01

    Full Text Available O objetivo deste estudo foi investigar a relação entre o consumo máximo de oxigênio, perfil lipídico e metabólico em meninas e meninos obesos e não-obesos. Estudo transversal, descritivo e correlacional. A amostra foi composta por 91 obesos e 30 não-obesos, dos 10 aos 16 anos. Avaliou-se o índice de massa corporal (IMC e a circunferência abdominal (CA. A aptidão cardiorrespiratória foi avaliada de forma direta através da análise do consumo máximo de oxigênio (O2max. Determinaram-se níveis de colesterol total (CT, lipoproteína de alta densidade (HDL-C, lipoproteína de baixa densidade (LDL-C, triglicérides (TG, glicemia e insulinemia após 12 horas de jejum. Analisaram-se os dados pelo teste "t" de student e correlação parcial controlada pela idade, com um nível de significância de pO2max com o IMC (r = -0,540; p O2max com a CT, a fração LDL-C e a glicemia.O menor VO2max correlacionou com maiores adiposidade, TG e insulinemia, bem como redução de HDL. O O2max não correlacionou com o CT, LDL-C e glicemia, sugerindo a importância do controle genético sobre estas variáveis e um menor tempo de influência do sedentarismo na população infanto-juvenil.The aim this study was investigates the relationship between maximum oxygen consumption, lipid and metabolic profile in obese and non-obese girls and boys. Transversal, descriptive and correlational study. 91 obese and 30 non-obese subjects participated, with 10 to 16 years. There were well overall adiposity by body mass index (BMI, and central adiposity by waist circumference (WC. The cardiorespiratory fitness was assessed by a direct analysis of maximum oxygen consumption (O2max. Are determined levels of total cholesterol (TC, high density lipoprotein (HDL-C, low density lipoprotein (LDL-C, triglycerides (TG, glucose and insulin after 12 hours of fasting. We analyzed the data by "t" student`s test and partial correlation controlled for age, with a significance level of p

  5. Risco nutricional e complicações em obesos hospitalizados submetidos à cirurgia Nutritional risk and complications in hospitalized obese patient submitted to surgery

    Directory of Open Access Journals (Sweden)

    Mariana Raslan

    2007-12-01

    Full Text Available RACIONAL: Risco nutricional mede o potencial de morbimortalidade associado ao estado nutricional. A obesidade é um distúrbio nutricional cada vez mais presente em hospitais gerais e pode estar acompanhada de alteração nutricional com conseqüências prejudiciais à evolução clínica do doente, além de ser fator associado a complicações pós-operatórias e morte. OBJETIVO: Identificar o risco nutricional através da ferramenta de triagem nutricional Malnutrition Universal Screening Tool e verificar o desfecho de complicações pós-operatórias, buscando associação entre risco nutricional e obesidade. MÉTODOS: Avaliaram-se 433 pacientes adultos hospitalizados em enfermarias cirúrgicas variadas, Na admissão hospitalar mediu-se peso e altura corpóreos. Aplicou-se a triagem nutricional após definição da obesidade pelo Índice de Massa Corpórea (Kg/m2 e classificação em grau I (30-34,99 Kg/m2; grau II (35-39,99 Kg/m2; grau III (±40,00 Kg/m². Os pacientes foram seguidos até a alta hospitalar ou óbito para acompanhar sua evolução clínica. RESULTADOS: Dentre os pacientes avaliados, 17,1% foram obesos. O risco nutricional nos pacientes obesos foi 23%. Ocorreram complicações em pacientes das enfermarias cirúrgicas de esôfago, vias biliares, vascular, cabeça e pescoço. As complicações apresentadas incluíram infecções pulmonares, de parede abdominal e urinária, fístulas gastrintestinal, biliar e pancreática, insuficiência respiratória, atelectasia lobar, e sangramento pós-operatório. CONCLUSÕES: Obesos hospitalizados podem apresentam risco nutricional sendo a obesidade grau I a mais freqüente entre eles em hospital geral. Houve associação positiva entre risco nutricional e freqüência de complicações justificando triagem nutricional na admissão hospitalar como rotina, incluindo pacientes com sobrepeso e obesidade.BACKGROUND: Nutritional risk measures the morbid-mortality potential associated to

  6. Vias aéreas e conteúdo gástrico no paciente obeso Vías aéreas y contenido gástrico en el paciente obeso The airways and gastric contents in obese patients

    OpenAIRE

    Leonardo de Andrade Reis; Guilherme Frederico Ferreira dos Reis; Milton Roberto Marchi de Oliveira

    2010-01-01

    JUSTIFICATIVA E OBJETIVOS: O presente artigo teve como objetivo rever as referências bibliográficas e questionar o conceito de que o obeso deve ser considerado de estômago cheio, questionando, consequentemente, a forma como a via aérea deve ser abordada na indução da anestesia geral, considerada de difícil acesso devido à obesidade. CONTEÚDO: Classicamente, o paciente obeso é considerado de estômago cheio, levando a condutas protetoras das vias aéreas durante a indução da anestesia geral. Fre...

  7. Células progenitoras endoteliais circulantes em crianças e adolescentes obesos

    Directory of Open Access Journals (Sweden)

    António Pires

    2015-12-01

    ão elevados em crianças e adolescentes obesos com comprovação de ativação endotelial. Isso sugere que, na infância, os mecanismos de reparação endotelial estão presentes no contexto da ativação endotelial.

  8. Scour properties of mono bucket foundation

    DEFF Research Database (Denmark)

    Stroescu, Ionut Emanuel; Frigaard, Peter Bak

    2016-01-01

    Field experience proved that the Mono Bucket Foundations (MBFs) have good response against scour development. Moreover, the ratio between large diameter (bucket lid) and the small diameter (shaft tower) is the driving parameter for the process of erosion/backfill, like scour protection diameter...... in the case of scour protected monopiles. However, the structural design to reduce the scour development for MBFs is still open to optimization. The influences of parameters that generate backfill and scour, the transfer load webs and the misalignment with seabed, have not been systematically studied until...

  9. Avaliação da composição corporal em adolescentes obesos: o uso de dois diferentes métodos Evaluación de la composición corporal en adolescentes obesos: uso de dos metodos diferentes Body composition evaluation in obese adolescents: the use of two different methods

    Directory of Open Access Journals (Sweden)

    Marco Túlio de Mello

    2005-10-01

    Full Text Available A pletismografia é um método rápido e fácil para determinação da composição corporal que utiliza a relação inversa entre pressão e volume. O objetivo do presente estudo foi o de comparar os valores obtidos com o método pletismografia com os valores observados com o DEXA em uma população de adolescentes obesos. Participaram da amostra 88 adolescentes pós-púberes de ambos os sexos, com idades entre 15 e 19 anos (17,01 ± 1,6 ingressantes de um programa de atividade física multidisciplinar. Os voluntários foram submetidos a uma avaliação da composição corporal em dias distintos dentro da mesma semana, pelo método de pletismografia e outra avaliação pelo método DEXA. Quando os métodos foram comparados, não se observaram diferenças significativas entre eles; além disso, foram observadas correlações significativas entre os parâmetros comuns dos dois métodos (massa magra, massa gorda (kg e massa gorda (%, r = 0,88 p La pletismografía es un método rápido y fácil para la determinación de la composición corporal que utiliza la relación inversa entre la presión y el volumen. El objetivo del presente estudio fué el de comparar los valores obtenidos con el metodo pletismografia con los valores observados con el DEXA en una población de adolescentes obesos. Participaron de la muestra 80 adolescentes post púberes de ambos sexos, con edades entre los 15 y los 19 años (17,01±1,6 iniciantes en un programa de actividad física multidisciplinar. Los voluntarios fueron sometidos a una evaluación de la composición corporal en días distintos dentro de la misma semana, por el método de pletismografia y otra evaluación por el método DEXA. Cuando se compararon los métodos, no fueron observadas diferencias significativas entre ellos, además de ello, fueron observadas correlaciones entre los parámetros comunes a los dos métodos (masa magra, masa grasa (kg y masa gorda (%, r = 0,88 p Plethysmography is an easy and

  10. On mono-W signatures in spin-1 simplified models

    Directory of Open Access Journals (Sweden)

    Ulrich Haisch

    2016-09-01

    Full Text Available The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artifact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  11. On mono-W signatures in spin-1 simplified models

    Energy Technology Data Exchange (ETDEWEB)

    Haisch, Ulrich [Oxford Univ. (United Kingdom). Rudolf Peierls Centre for Theoretical Physics; CERN, Geneva (Switzerland). Theory Div.; Kahlhoefer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Tait, Tim M.P. [California Univ., Irvine, CA (United States). Dept. of Physics and Astronomy

    2016-03-15

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artefact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  12. Factores relacionados con la pérdida de peso en una cohorte de pacientes obesos sometidos a bypass gástrico

    Directory of Open Access Journals (Sweden)

    Adriana Giraldo Villa

    2013-06-01

    Full Text Available Introducción: La obesidad es catalogada como la epidemia del siglo XXI. El tratamiento médico multidisciplinario no ha sido suficiente y las técnicas quirúrgicas son empleadas con mayor frecuencia. El bypass gástrico es considerado el gold standard de la cirugía bariátrica, sin embargo, algunos pacientes reportan bajas tasas de pérdida de peso, lo que hace pensar en otros factores condicionantes. Objetivo: Establecer los factores asociados con la pérdida de peso, en una cohorte de pacientes obesos sometidos a bypass gástrico. Métodos: Estudio analítico retrospectivo. La variable respuesta fue la pérdida de peso, expresada en porcentaje del exceso de índice de masa corporal perdido (PEIMCP. Se realizó un modelo de regresión lineal de efectos mixtos y un modelo de riesgos proporcionales de COX. Resultados: Se estudiaron 166 pacientes entre 19 y 69 años, la mayoría mujeres (74,7%. Los hombres presentaron un índice de masa corporal (IMC inicial promedio de 46,9 ± 6,8 kg/m² y las mujeres de 46,3 ± 7,7 kg/m². El análisis multivariado mostró que por cada 10,0 kg/m² de mas al momento de la cirugía, disminuyó el PEIMCP en un 9,8% y un inadecuado consumo calórico diario disminuyó en un 4,0% el PEIMCP. Por cada 10,0 kg/m² de IMC inicial, hubo una disminución del 57,8% en la probabilidad de lograr una pérdida de peso del 50%. Conclusiones: Los pacientes con menor exceso de peso según su índice IMC responden mejor a la cirugía bariátrica en términos del PEIMCP.

  13. Características miofuncionais de obesos respiradores orais e nasais Myofunctional characteristics of obese mouth and nose breathers

    Directory of Open Access Journals (Sweden)

    Denise Bolzan Berlese

    2012-06-01

    Full Text Available OBJETIVO: Investigar as características miofuncionais de obesos respiradores orais e nasais. MÉTODOS: Foram selecionados por conveniência 24 obesos, com idades entre 8 e 15 anos, pertencentes ao Grupo de Obesidade do Ambulatório de Pediatria de um Hospital Universitário. As características miofuncionais foram avaliadas por meio do protocolo de Avaliação Miofuncional Orofacial com Escalas (AMIOFE. RESULTADOS: Foi observada respiração oral em 62,5%, e respiração nasal em 37,5% da população estudada. No grupo de respiradores orais, 40% apresentaram oclusão com tensão dos lábios e 80% palato com largura diminuída, enquanto que quase todos os respiradores nasais tinham palato e lábios com postura normal. Interposição da língua nos arcos dentários ocorreu em 47% dos respiradores orais e em nenhum dos respiradores nasais. Os respiradores orais mostraram tendência em não repetir a deglutição de um mesmo bolo alimentar. A aparência da face, condição postural da mandíbula, bochechas e função de mastigação foram semelhantes nos dois grupos. CONCLUSÃO: A respiração oral em crianças e adolescentes obesos foi acompanhada de alterações miofuncionais do sistema estomatognático, representadas por diminuição da largura do palato, interposição da língua aos arcos dentários, oclusão dos lábios com tensão e alteração da deglutição.PURPOSE: To investigate the myofunctional characteristics of nasal and oral breathing in obese individuals. METHODS: Participants were 24 obese individuals with ages between 8 and 15 years, who participated in the Obesity Group of the Ambulatory of Pediatrics of an University Hospital, and were selected by convenience. The myofunctional characteristics were assessed using the Orofacial Myofunctional Assessment with Scales (Avaliação Miofuncional Orofacial com Escalas - AMIOFE protocol. RESULTS: Oral breathing was present in 62.5%, and nasal breathing in 37.5% of the population

  14. Método do limiar de variabilidade da frequência cardíaca aplicado em pré-adolescentes obesos e não obesos Método del umbral de variabilidad de la frecuencia cardíaca aplicado en preadolescentes obesos y no obesos Method of heart rate variability threshold applied in obese and non-obese pre-adolescents

    Directory of Open Access Journals (Sweden)

    Mário Augusto Paschoal

    2011-06-01

    Full Text Available FUNDAMENTO: A detecção do limiar anaeróbico (LA pela análise da variabilidade da frequência cardíaca (LiVFC pode significar uma nova maneira de avaliação da capacidade funcional cardiorrespiratória (CFCR em pré-adolescentes. OBJETIVO: Testar o método de LiVFC para detecção do LA em pré-adolescentes não obesos (NO, obesos (O e obesos mórbidas (OM, a fim de determinar diferenças em sua CFCR. MÉTODOS: Foram estudados 30 pré-adolescentes, com idades entre 9 e 11 anos, divididos em três grupos de 10: a grupo NO - índice de massa corpórea (IMC com percentil do National Center for Chronic Disease Prevention and Health Promotion entre 5 e 85; b grupo O - IMC de percentil entre 95 e 97 e c grupo OM - IMC com percentil acima de 97. Todos foram submetidos a um protocolo incremental realizado em esteira rolante e registraram-se os batimentos cardíacos para detecção do LiVFC, que foi determinado pelo valor de 3,0 ms do índice do desvio-padrão 1 (SD1, extraído dos intervalos RR. RESULTADOS: Os valores médios no momento do LiVFC mostraram maiores valores para o grupo NO, destacando-se: a VO2 (ml/kg/min NO = 27,4 ± 9,2; O = 13,1 ± 7,6 e OM = 11,0 ± 1,7; b FC (bpm: NO = 156,3 ± 18,0; O =141,7 ± 11,4 e OM = 137,7 ± 10,4; e c distância percorrida (metros: NO = 1.194,9 ± 427,7; O = 503,2 ± 437,5 e OM = 399,9 ± 185,1. CONCLUSÃO: O LiVFC se mostrou efetivo para avaliação da CFCR e poderá vir a ser aplicado como método alternativo à ergoespirometria em determinadas situações.BACKGROUND: La detección del umbral anaeróbico (UA por el análisis de la variabilidad de la frecuencia cardíaca (LiVFC puede significar una nueva manera de evaluación de la capacidad funcional cardiorrespiratoria (CFCR en preadolescentes. OBJECTIVE: Testear el método de LiVFC para detección del UA en preadolescentes no obesos (NO, obesos (O y obesos mórbidos (OM, a fin de determinar diferencias en su CFCR. METHODS: Fueron estudiados 30

  15. Was Mono Lake a 14C dump?

    Science.gov (United States)

    Maggs, William Ward

    This is a scientific story without an explanation, called a “mystery” and an “enigma” in articles by the people who discovered it. Confounded by evidence they cannot explain by natural processes, these scientists implicate human beings.One month ago in Eos, (June 7, 1988, p. 633), Wallace Broecker and Scott Stine reported abnormally high levels of radiogenic 14C in California's Mono Lake, now a National Historic Site. The only logical explanation, they proposed, is that someone secretly dumped a total of about 20 curies of 14C into the lake in two doses, sometime between 1952 and 1958 and again between 1966 and 1977. Broecker and Stine, geologists at Lamont-Doherty Geological Observatory in Palisades, N.Y., called on readers for information on the source of the 14C.

  16. Intercultural Interactions of Mono-Cultural, Mono-Lingual Local Students in Small Group Learning Activities: A Bourdieusian Analysis

    Science.gov (United States)

    Colvin, Cassandra; Fozdar, Farida; Volet, Simone

    2015-01-01

    This research examines the understandings and experiences of mono-cultural, mono-lingual local students in relation to intercultural interactions within small group learning activities at university. Bourdieu's concepts of field, habitus and capital are employed to illuminate a number of barriers to intercultural interaction. Using qualitative…

  17. Expresión génica en pacientes obesos con enfermedad hepática por depósito de grasa Gene expression in obese patients with non-alcoholic steatohepatitis

    Directory of Open Access Journals (Sweden)

    A. Cayón

    2008-04-01

    Full Text Available La fisiopatología de la enfermedad hepática por depósito de grasa sólo se conoce de forma parcial. En este trabajo hemos analizado la expresión génica intrahepática de citoquinas, quimioquinas, receptores celulares, factores de crecimiento, transductores de señales intracelulares y proteínas de comunicación extracelular en el tejido hepático de sujetos obesos con y sin esteatohepatitis no alcohólica, en un intento de determinar un perfil de expresión génica asociado a las formas severas de la esteatohepatitis no alcohólica (EHNA. Se analizó un grupo de 38 pacientes obesos con un IMC > 35, que fueron sometidos a cirugía bariátrica. La expresión génica intrahepática se determinó en el tejido hepático dividiendo a los pacientes en tres grupos: a pacientes obesos sin datos histológicos sugestivos de EHNA (n = 12; b pacientes con EHNA sin fibrosis (n = 13; y c pacientes con EHNA y fibrosis (n = 13. Se consideró que existía una sobreexpresión génica cuando la diferencia en la expresión era, al menos, de dos veces con respecto al grupo control. Los resultados se confirmaron mediante PCR en tiempo real. Se detectó una expresión diferencial de 14 genes (10 sobreexpresados y 4 infraexpresados. Los genes sobreexpresados incluyeron prohibitina, TNF, TNF RI (p55, MCSF, R2-TRAIL, TGF-b1, CTGF, FGF, VEGF, BIGH3 y ObRb. La expresión de los genes insulin growth factor-1, insulin growth factor-2, interleuquina-2 y tyrosine-receptor fue menor que en el grupo control. En conclusión: 1. Los pacientes obesos con EHNA sin fibrosis muestran una sobreexpresión de genes proinflamatorios y proapoptóticos. En los pacientes con EHNA y fibrosis, se observa, además, una sobreexpresión de genes profibrogénicos, incluyendo el gen del receptor de la leptina. 2. La expresión de prohibitiva en los pacientes con EHNA, tanto con fibrosis como sin fibrosis, fue superior que en los controles, lo que sugiere una disfunción mitocondrial en los

  18. Tornar-se obeso na adolescência pode trazer consequências à saúde mental?

    Directory of Open Access Journals (Sweden)

    Maria Cecília Formoso Assunção

    2013-09-01

    Full Text Available O estudo avaliou a associação entre trajetória de obesidade e dificuldades emocionais e comportamentais em adolescentes. Foram estudados 4.325 jovens, aos 11 e 15 anos de idade, pertencentes à coorte de nascimentos de 1993 de Pelo-tas, Rio Grande do Sul, Brasil. Informações sobre índice de massa corporal (IMC, avaliação materna da saúde emocional e comportamental do adolescente (Strengths and Difficulties Questionnaire - SDQ e características sociodemográficas e comportamentais foram utilizadas. As análises, estratificadas por sexo, foram conduzidas por meio de regressão linear simples e múltipla. A trajetória de obesidade mostrou associação com o escore total do SDQ, nas análises ajustadas, apenas entre os meninos. Entre esses, tornar-se obeso no período esteve relacionado com maior escore na subescala de problemas de relacionamento com os colegas. Diante do conhecimento atual sobre as implicações futuras da obesidade na saúde mental e em se tratando de adolescentes, sugere-se que estudos que avaliem as diferenças de gênero na adolescência possam contribuir para o entendimento da associação encontrada.

  19. Qualidade de sono de trabalhadores obesos de um hospital universitário: acupuntura como terapia complementar

    Directory of Open Access Journals (Sweden)

    Mariana Lourenço Haddad

    2012-02-01

    Full Text Available O objetivo do estudo foi verificar o efeito da acupuntura na qualidade de sono de trabalhadores obesos em um hospital universitário. Os dados foram coletados no período de julho a outubro de 2009, junto a 37 funcionários, submetidos a oito aplicações semanais de acupuntura. O Índice de Qualidade de Sono de Pittsburgh foi utilizado para identificar a qualidade de sono dos sujeitos antes e após a intervenção. Os resultados mostram que antes da intervenção cinco (13,5% pessoas apresentaram boa qualidade de sono e, ao final da intervenção, 14 (37,8% relataram este quadro. A diferença obtida na comparação das médias dos escores obtidos antes e após a acupuntura foi significativa (p=0,0001. Concluiu-se que a acupuntura produziu um efeito positivo sobre a qualidade do sono na amostra estudada, apresentando-se como uma técnica adjuvante no tratamento dos distúrbios do sono e consequentemente na melhoria da qualidade de vida desta população.

  20. Mono Lake Excursion in Cored Sediment from the Eastern Tyrrhenian Sea

    Science.gov (United States)

    Liddicoat, Joseph; Iorio, Marina; Sagnotti, Leonardo; Incoronato, Alberto

    2013-04-01

    A search for the Laschamp and Mono Lake excursions in cored marine and lacustrine sediment younger than 50,000 years resulted in the discovery of both excursions in the Greenland Sea (73.3˚ N, 351.0˚ E, Nowaczyk and Antanow, 1997), in the North Atlantic Ocean (62.7˚ N, 222.5˚ E, Channell, 2006), in Pyramid Lake in the Lahontan Basin, NV, USA (40.1˚ N, 240.2˚ E, Benson et al., 2008), and in the Black Sea (43.2˚ N, 36.5˚ E, Nowaczyk et al., 2012). The inclination, declination, and relative field intensity during the Mono Lake Excursion (MLE) in the Black Sea sediment matches well the behaviour of the excursion in the Mono Basin, CA, in that a reduction in inclination during westerly declination is soon followed by steep positive inclination when declination is easterly, and relative field intensity increases after a low at the commencement of the excursion (Liddicoat and Coe, 1979). A large clockwise loop of Virtual Geomagnetic Poles (VGPs) at the Black Sea when followed from old to young patterns very well the VGP loop formed by the older portion of the MLE in the Mono Basin (Liddicoat and Coe, 1979). We also searched for the MLE in cored sediment from the eastern Tyrrhenian Sea (40.1˚ N, 14.7˚ E) where the age of the sediment is believed to be about 32,000 years when comparing the susceptibility in the core with the susceptibility in a nearby one that is dated by palaeomagnetic secular variation records, Carbon-14, and numerous tephra layers in the Tyrrhenian Sea sediment (Iorio et al., 2011). In the Tyrrhenian Sea core, called C1067, closely spaced samples demagnetized in an alternating field to100 mT record a shallowing of positive inclination to 48˚ that is followed by steep positive inclination of 82˚ when declination moves rapidly to the southeast. The old to young path of the VGPs in C1067 forms a narrow counter-clockwise loop that reaches 30.3˚ N, 30.8˚ E and that is centered at about 55˚ N, 15˚ E. Although descending to a latitude that is

  1. Professional Android Programming with Mono for Android and NETC#

    CERN Document Server

    McClure, Wallace B; Croft, John J; Dick, Jonathan; Hardy, Chris

    2012-01-01

    A one-of-a-kind book on Android application development with Mono for Android The wait is over! For the millions of .NET/C# developers who have been eagerly awaiting the book that will guide them through the white-hot field of Android application programming, this is the book. As the first guide to focus on Mono for Android, this must-have resource dives into writing applications against Mono with C# and compiling executables that run on the Android family of devices. Putting the proven Wrox Professional format into practice, the authors provide you with the knowledge you need to become a succ

  2. Modeling of dielectric barrier discharge excimer lamp excited by mono polar voltage pulses

    Science.gov (United States)

    Akashi, Haruaki; Oda, Akinori; Sakai, Yosuke

    2007-10-01

    Filametal discharges in Dielectric Barrier Discharge (DBD) excimer lamp excited by mono polar voltage pulses has been simulated using two dimensional fluid model. And the differences of the filament discharges formations between mono polar case and bipolar case [1] have been examined. Xe gas was used and its pressure is 300Torr. Simulated region is 1cm (gap length) x 3cm (radial length). Periodical boundary conditions are assumed for the radial direction boundaries. The both electrodes are covered with dielectrics and their thickness is 0.2cm. Applied voltage is 5kV trapezoid shape with 50% duty ratio waveform and its repetition rate is 200kpps. First a small amount of electron-ion pair is provided in the middle of the gap for initial condition. Then the voltage starts to apply. In the case of bipolar excitation, the discharge starts from one filament (streamer discharge), and finally, 5 filaments are obtained self-consistently. In the case of mono polar case, as first, similar to bipolar case, the discharge starts from one filament, however, only 3 filaments have been obtained. This result is similar to that of 100kHz bipolar voltage case. [1] H. Akashi et al, IEEE Trans. Plasma Science, Vol.33, No.2 (2005) pp.308-309

  3. Prevalência de insuficiência venosa superficial dos membros inferiores em pacientes obesos e não obesos Prevalence of lower limbs superficial venous insufficiency in obese and non-obese patients

    Directory of Open Access Journals (Sweden)

    Amélia Cristina Seidel

    2011-06-01

    Full Text Available CONTEXTO: A insuficiência venosa crônica dos membros inferiores é a mais prevalente das doenças venosas. Muito se discute sobre sua etiologia e fisiopatologia. Vários fatores de risco têm sido associados ao seu desenvolvimento, como idade, sexo, dieta, entre outros. A obesidade é um problema de saúde pública e sua incidência tem aumentado. O ecocolor Doppler é um método útil para avaliar a presença de refluxo e/ou obstrução no sistema venoso. OBJETIVO: Comparar a prevalência de insuficiência venosa superficial e sintomas associados em pacientes obesos e não obesos. MÉTODOS: Após pesagem, medição da estatura e exame físico, os pacientes com índice de massa corpórea (IMC 35 kg/m² e queixas compatíveis com insuficiência venosa foram distribuídos nos grupos I e II, respectivamente. Foram submetidos à realização do ecocolor Doppler dos membros inferiores para avaliação da presença ou não de refluxo. RESULTADOS: Foram examinados 311 membros de 168 pacientes com 25-72 anos. Para análise estatística, foram consideradas queixas de varizes, dor, edema, dermatite, eczema e úlcera, associados ou não. Foi obtido um total de 109 e 104 membros com varizes nos grupos I e II, respectivamente. Queixas de varizes visíveis (pBACKGROUND: Chronic venous insufficiency of the lower limbs is the most prevalent venous disease. There is an ongoing debate about its etiology and pathophysiology. Several risk factors have been associated with its development, such as age, sex and diet. Obesity is a public health problem and its prevalence has been increasing. Color Doppler ultrasonography is a useful method to evaluate the presence of reflux and/or obstruction of the venous system. OBJECTIVE: To compare the prevalence of superficial venous insufficiency and associated symptoms in obese and non-obese patients. METHODS: After weighing, height measurement and physical examination, patients with body mass index (BMI 35 kg/m² and

  4. Respostas fisiológicas ao exercício agudo em ratos obesos tratados com metformina Physiological responses to intense exercise in obese rats treated with metformin

    Directory of Open Access Journals (Sweden)

    Gustavo Gomes de Araujo

    2007-12-01

    Full Text Available O objetivo do presente estudo foi investigar as respostas fisiológicas ao exercício agudo em ratos Wistar obesos, tratados com metformina. Os animais receberam injeção subcutânea de glutamato monossódico (4mg/g peso corporal, para indução da obesidade. Os animais foram divididos em 4 grupos, conforme o tratamento recebido: obesos controles (OC; obesos metformina (OM; obesos controles exercitados (OCE e obesos metformina exercitados (OME. Foram analisados, antes e após uma sessão de exercício agudo: glicose sérica (mg/dL, triglicerídeos (g/100g, colesterol total (mg/dL e hematócrito (%. Os valores de glicose sérica e colesterol total foram reduzidos significativamente no grupo controle exercitado (OCE - 68,4 ± 14,7 e 70,8 ± 18,3 em comparação ao grupo controle sedentário (OC - 83,6 ± 12,8 e 91,3 ± 9,6. A administração de metformina isoladamente diminuiu a concentração de glicose de 83,6 ± 12,8 (OC para 70,8 ± 5,9 (OM. Por outro lado, a associação de metformina com exercício aumentou a disponibilidade de triacilgliceróis livres após a atividade (OM - 166,6 ± 11,3, OME - 184,0 ± 4,3. Em conclusão o programa de intervenção utilizado (exercício físico agudo mostrou-se eficiente na homeostasia glicêmica, bem como, nos níveis circulantes de lipídios em ratos obesos tratados com metformina.The purpose of the present study was to investigate the physiological responses to intense exercise in obese Wistar rats treated with metformin. To induce obesity, all animals were infused with monosodic glutamate (4 mg/g of body weight via subcutaneous injection. The rats were divided in 4 groups according to the received treatment: obese control (OC; obese metformin ( OM; obese control exercise (OCE and obese metformin exercise (OME. Before and after one session of intense exercise the following parameters were measured: serum glucose (mg/dl, triglycerides (g/100g, total cholesterol (mg/dl and haematocrit (%. The values of

  5. Greater Sage-grouse Telemetry - Mono Co. [ds68

    Data.gov (United States)

    California Department of Resources — Combined telemetry locations for sage grouse in Mono County which were fitted with radio-transmitters for the USGS Greater sage-grouse project. Contains spatial and...

  6. Adiposidade corporal e hipertensão arterial em crianças e adolescentes obesos - doi:10.5020/18061230.2009.p88

    Directory of Open Access Journals (Sweden)

    Joel Saraiva Ferreira

    2012-01-01

    Full Text Available Objetivo: Investigar a relação entre a hipertensão arterial e adiposidade corporal em crianças e adolescentes obesos. Métodos: Estudo transversal no qual 129 crianças e adolescentes obesos de ambos os gêneros com idade variando de 7 a 14 anos foram avaliados. A adiposidade foi caracterizada a partir dos dados obtidos como: índice de massa corporal (IMC, percentual de gordura corporal (%GC e relação cintura-quadril (RCQ. O grupo foi dividido em dois subgrupos (normotensos e hipertensos mediante o nível de pressão arterial (PA. O teste estatístico de Kruskal Wallis foi empregado para determinar a significância na relação entre dados antropométricos e níveis de pressão arterial. Adotou-se um valor de p ? 0,05. Resultados: Verificou-se que 101 (78,29% participantes eram normotensos e 28 (21,71% hipertensos. Em relação à adiposidade, o grupo dos hipertensos apresentou níveis mais elevados de IMC e o %GC quando comparado com o normotenso (p<0,05. A partir dos dados da RCQ, não houve associação estatística entre a relação cintura-quadril e o nível pressórico. Conclusões: As crianças e adolescentes obesos apresentaram relação estatisticamente significativa entre adiposidade corporal e níveis de pressão arterial; no entanto, a localização da gordura não foi um fator determinante desta diferença.

  7. Isotope-specific detection of low density materials with mono-energetic (gamma)-rays

    Energy Technology Data Exchange (ETDEWEB)

    Albert, F; Anderson, S G; Gibson, D J; Hagmann, C A; Johnson, M S; Messerly, M J; Semenov, V A; Shverdin, M Y; Tremaine, A M; Hartemann, F V; Siders, C W; McNabb, D P; Barty, C J

    2009-03-16

    The first demonstration of isotope-specific detection of a low-Z, low density object, shielded by a high-Z and high density material using mono-energetic gamma-rays is reported. Isotope-specific detection of LiH shielded by Pb and Al is accomplished using the nuclear resonance fluorescence line of {sup 7}Li at 0.478 MeV. Resonant photons are produced via laser-based Compton scattering. The detection techniques are general and the confidence level obtained is shown to be superior to that yielded by conventional x-ray/{gamma}-ray techniques in these situations.

  8. Electron impact single ionization of mono- and di-positive ions

    Indian Academy of Sciences (India)

    M Alfaz Uddin; A K F Haque; M S Mahbub; K R Karim; A K Basak

    2006-06-01

    The electron impact ionization cross-sections of mono- and di-positive ionic targets are calculated using a second version of the modified binary-encounter-dipole (MBED) model, previously reported [M A Uddin et al, J. Phys. B37, 1909 (2004)]. The present version differs from the previous one in the scale factor of the Burgess denominator and is applicable to targets with charges = 1 and 2. The MBED in the present form is found to work well for 11 ionic targets ranging from Be+ to K+ and complements its previous version valid for targets with > 2.

  9. New mono-organotin (IV) dithiocarbamate complexes

    Science.gov (United States)

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim

    2014-09-01

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S2CNR'R″]2 (R= Ph, CH3, R' = CH3, C2H5, C7H7 and R″ = C2H5, C6H11, iC3H7, C7H7). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, 1H, 13C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444-1519, 954-1098 and 318-349 cm-1 respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 - 259 nm due to the intramolecular charge transfer of the ligand. The 13C NMR spectra showed an important shift for δ(N13CS2) in the range of 196.8 - 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S2CN(Et)(i-Pr)]2, MeSnCl[S2CN(Me)(Cy)]2 and MeSnCl[S2CN(i-Pr)(CH2Ph)]2. All structures having a distorted octahedral geometry set by CClS4 donor atom from the two chelating dithiocarbamate ligands.

  10. Influencia de un programa de actividad física en niños y adolescentes obesos con apnea del sueño: protocolo de estudio

    OpenAIRE

    M. J. Aguilar Cordero; A. M. Sánchez López; N. Mur Villar; A. Sánchez Marenco; R. Guisado Barrilao

    2013-01-01

    Estudios recientes muestran un incremento alarmante en la tasa de sobrepeso/obesidad entre la población infanto-juvenil. La obesidad en la infancia se asocia con un importante número de complicaciones, como síndrome de apnea del sueño insulinorresistencia y diabetes tipo 2, hipertensión, enfermedad cardiovascular, algunos tipos de cáncer. Se estima que la prevalencia de apnea en niños es de un 2-3% en la población general, mientras que, en adolescentes obesos, varía entre el 13% y el 66%, seg...

  11. Modelo educativo nutricional para la reducción de factores de riesgo cardiovascular en niños escolares obesos

    OpenAIRE

    María del Pilar Suárez de Ronderos; Viviana Esquivel Solís

    2003-01-01

    El objetivo de esta investigación fue evaluar la efectividad de un modelo de educación nutricional para la reducción de factores de riesgo de enfermedad cardiovascular en niños escolares obesos. Se realizó un diagnóstico previo para identificar las características generales de este grupo de niños y determinar el estado nutricional, los conocimientos, las actitudes y las prácticas alimentarlas relacionadas con factores de riesgo cardiovascular. El estudio de tipo casi experimental incluyó 31 n...

  12. Analysis of the stimulated whole saliva in overweight and obese school children Análise da saliva total estimulada em escolares com sobrepeso e obesos

    Directory of Open Access Journals (Sweden)

    Eliana Pannunzio

    2010-01-01

    Full Text Available OBJECTIVE: To determine if some stimulated whole saliva parameters are influenced by an increase of Body Mass Index. METHODS: Controlled cross-sectional study involving 90 school children of both genders between 7 and 10 years of age, from Bragança Paulista - SP. Three groups were formed: overweight, obese and control. Body Mass Index and diet intake by the Food Register method were evaluated. The salivary pH, flow rate, buffer capacity, protein, phosphate, calcium, fluoride, total and free sialic acid, and peroxidase activity were determined. RESULTS: The overweight and obese groups showed greater energy and lipid intake (POBJETIVO: Verificar se alguns parâmetros da saliva total estimulada são influenciados pelo aumento do Índice de Massa Corporal. MÉTODOS: Estudo transversal controlado com 90 escolares, de ambos os sexos, de 7 a 10 anos incompletos de Bragança Paulista, SP, formando três grupos: sobrepeso, obeso e controle. Avaliou-se o Índice de Massa Corporal (P/E2 e a ingestão dietética pelo registro alimentar. Na saliva foram avaliados o fluxo, pH, capacidade tampão e concentrações de proteína, fósforo, cálcio, flúor, ácido siálico livre e total e atividade da peroxidase. RESULTADOS: Nos grupos sobrepeso e obeso houve maior consumo de energia e lipídios (P<0,001. Não houve diferença no fluxo salivar entre todos os grupos, mas somente o controle mostrou valor médio considerado normal. O pH salivar do grupo sobrepeso foi maior do que o do controle (P<0,001. Nos grupos sobrepeso e obeso houve decréscimo na concentração de fosfato (P<0,001 e na atividade da peroxidase (P<0,001. No grupo obeso houve aumento nas concentrações de ácido siálico livre (P= 0,004 e proteína (P= 0,003. CONCLUSÃO: Crianças com sobrepeso e obesas apresentam alterações nas concentrações salivares de fosfato, ácido siálico livre e proteínas e na atividade da peroxidade, as quais favorecem a formação de cárie dentária.

  13. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

    Directory of Open Access Journals (Sweden)

    Thiago Bruder Nascimento

    2011-07-01

    Full Text Available FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C e obeso (OB, ratos sob dieta rica em gordura por 30 semanas. Após 30 semanas, foram registrados o peso corporal, índice de adiposidade, pressão arterial e perfis metabólicos e endócrinos dos animais. Foram obtidas curvas para noradrelanina na ausência e presença de inibidor de óxido nítrico sintase (L-NAME, 3x10-4M em aorta torácica intacta e com desnudamento em ratos C e OB. RESULTADOS: As medidas de peso corporal, índice de adiposidade, leptina e insulina aumentaram nos ratos OB, enquanto a pressão arterial permaneceu inalterada. A obesidade também produziu tolerância à glicose e resistência à insulina. A reatividade à noradrenalina da aorta intacta foi similar em ratos C e OB. A presença de L-NAME produziu um aumento similar nas respostas máximas, mas um desvio maior à esquerda das respostas nas aortas intactas dos ratos C em relação aos ratos OB [EC50 (x10-7M: C = 1,84 (0,83-4,07, O = 2,49 (1,41-4,38; presença de L-NAME C = 0,02 (0,01-0,04*, O = 0,21 (0,11-0,40*†,*p < 0,05 vs controle respectivo,†p < 0,05 vs controle mais L-NAME, n = 6-7]. Nenhum dos protocolos alterou a reatividade à noradrenalina de aortas com desnudamento. CONCLUSÃO: A obesidade induzida por dieta rica em gordura promove alterações metabólicas e vasculares. A alteração vascular envolveu uma melhora da via endotelial L-arginina/NO provavelmente relacionada à hiperinsulinemia e hiperleptinemia induzidas por dieta. A maior resistência aos efeitos do L-NAME na aorta de ratos obesos diz respeito a menor vulnerabilidade de indivíduos obesos na presença de patologias

  14. Riesgo cardiovascular en el adolescente obeso: reversibilidad clínica, metabólica y de la pared vascular tras una intervención

    OpenAIRE

    París Miró, Neus

    2010-01-01

    1.- Contribuciones y conocimientos nuevos que aporta la tesis:Los adolescentes obesos presentan aumento del riesgo cardiovascular. Existe una gradación de dicho riesgo cardiovascular que puede medirse através del estudio de diferentes variables.La mayoría de los factores de riesgo cardiovascular, así como el aumento del grosor íntima-media carotídeo, pueden ser reversibles tras una intervención Higiénico-Nutricional basada en objetivos.2.- Metodología utilizada y conclusiones más relevantes...

  15. Estudio in vivo de la oxidación mitocondrial en pacientes obesos tratados mediante restricción calórica

    OpenAIRE

    Parra, M.D. (M.D.); Martinez-de-Morentin, B.E. (B.E.); Perez-Silanes, S.; Rodriguez, M. C. [UNESP; Martinez, J A

    2004-01-01

    La restricción calórica es la terapia nutricional más frecuente en el tratamiento de la obesidad, cuya eficacia depende de la respuesta oxidativa del organismo para evitar la modificación del peso corporal. En este contexto, el objetivo del presente trabajo fue examinarin vivo la oxidación mitocondrial de voluntarios obesos, antes y después de adelgazar, utilizando el test en aliento con 2-ceto[1-13C]isocaproato. El estudio se realizó en 32 voluntarios de ambos sexos: 16 controles (índice de ...

  16. Treinamento físico aeróbio previne à hipertrofia cardíaca patológica e melhora a função diastólica em ratos Zucker obesos

    OpenAIRE

    Barretti, Diego Lopes Mendes; Carmo,Everton Crivoi do; Rosa, Kaleizu Teodoro; Irigoyen, Maria Claudia Costa; Oliveira, Edilamar Menezes

    2011-01-01

    A obesidade é uma patologia diretamente relacionada com o desenvolvimento de doenças cardiovasculares. Por outro lado, o treinamento físico aeróbio atenua o desenvolvimento da obesidade e promove benefícios cardíacos em obesos. Dessa forma, nosso objetivo foi investigar se a obesidade altera a função cardíaca e se sua associação com o treinamento físico aeróbio promove melhora na função cardíaca em ratos Zucker obesos. Os ratos Zucker foram divididos da seguinte forma: grupo magro (GM), grupo...

  17. Uso do ultra-som para punção venosa central em paciente obeso com adenomegalia cervical

    Directory of Open Access Journals (Sweden)

    Jaderson Wollmeister

    2008-08-01

    Full Text Available JUSTIFICATICA E OBJETIVOS: As técnicas clássicas para punção venosa central são realizadas com base em referências anatômicas de superfície e conhecimento da anatomia vascular da região em que se realizará a punção. O uso do ultra-som permite a realização da punção sob visão direta das estruturas vasculares, peri-vasculares e da agulha de punção. O objetivo deste relato foi descrever o uso do ultra-som no auxílio de acesso venoso central em paciente obeso e com adenomegalias. RELATO DO CASO: Paciente do sexo masculino, branco, 28 anos, 1,70 m, 120 kg, com diagnóstico de linfoma de Hodgkin esclerose nodular. Solicitado ao Serviço de Anestesiologia do Hospital Governador Celso Ramos, punção de veia jugular interna direita guiada por ultra-som devido à presença de gânglio supraclavicular que prejudicava a referência anatômica de punção e à obesidade do paciente. Após a obtenção da melhor imagem a veia jugular interna esquerda foi puncionada e colocado um cateter venoso de triplo lúmen. A punção foi única, com progressão fácil do cateter e realizada sem complicações. CONCLUSÕES: O uso da ultra-sonografia para punção venosa central pode evitar complicações tornando o procedimento mais seguro para o paciente.

  18. Problematização como estratégia de educação nutricional com adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Rodrigues Érika Marafon

    2006-01-01

    Full Text Available Obesidade é um problema de saúde pública em cuja etiologia determinantes sociais têm relevância, sendo que intervenções com adolescentes encontram condição biopsicossocial complexa. A pesquisa avaliou intervenção de educação nutricional, empregando o método da problematização, com 22 adolescentes obesos, atendidos coletiva e individualmente, durante oito meses. Falas foram coletadas mediante emprego de tarjetas, registro por observador e gravação. O método foi qualitativo e a técnica, a análise de conteúdo. A problematização mostrou-se instrumento facilitador para mudança de comportamento alimentar, fazendo emergir reflexões sobre: práticas alimentares, contexto familiar, estigma social, relacionamento com profissionais de saúde, religiosidade. Os adolescentes em atendimento individual problematizaram com mais efetividade práticas alimentares, enquanto no coletivo houve maior problematização dos aspectos familiares e psicológicos, com efetivas mudanças qualitativas na alimentação de ambos os grupos. Concluiu-se que a intervenção foi eficaz para ajudar os adolescentes a compreenderem sua história de vida e determinantes do comportamento alimentar, efetivarem mudanças na sua alimentação espontaneamente, conscientizarem-se das possibilidades de perpetuação da mudança das práticas alimentares e exercerem com autonomia o papel de sujeitos no cuidado à saúde.

  19. La poesía ebanita y su precursor Candelario Obeso

    Directory of Open Access Journals (Sweden)

    Ramiro Lagos

    1983-01-01

    Full Text Available Colombia, crisol de un claro mestizaje acriollado, donde la raza se funda, no en el color sino en el bronce de su valor y de su épica, unido a esa patina de cultura que da al colombiano un perfil singular, es quizá una de las naciones que más se han liberado, por su cultura, de las consabidas discriminaciones que separan al blanco del negro, del mulato y del aindiado. No es Colombia un país estrictamente criollo como las naciones rioplatenses que se precian de su ancestro europeo. Sin embargo, tan criollo culturalmente, se enorgullece de serlo el colombiano como aquel que lo es por dictados de la sangre ancestral, considerándose Colombia uno de los países más hispánicos, no sólo por la sangre cultural que colma su espíritu neorenacentista, sino por el purismo de su lenguaje castizo con que se expresan, para hablar con énfasis y claridad, las voces múltiples de sus portavoces raciales.

  20. An Analysis of the Magma Supply System at Mono Craters, California. Michelle R. Johnson and Keith Putirka

    Science.gov (United States)

    Johnson, M.; Putirka, K. D.

    2012-12-01

    The Mono Craters consist of 28 sequentially numbered domes, craters, and coulees, oriented north to south, located at the northern end of the Long Valley magmatic system. It is thought that the plumbing system underneath the Mono Craters is a series of dikes, sills, and small magmatic bodies. What remains unclear are the P-T conditions of magma storage and how such conditions may affect upward transport of magma. Seismological constraints exist, which place some magma storage at 8-10 km (Achauer 1986), with the Moho ~30 km (Frasetto et al, 2011). Whole rock analyses and mineral composition data allow us to estimate P and T conditions using mineral-melt thermobarometers and refine magma storage conditions. Pressures were determined using Q-Or-Ab phase relationships. Whole rock compositions indicate that the Mono Craters erupted three compositionally separate batches of magma. Mafic samples at Mono Craters range from 52.7% - 60.45% SiO2, with pressures varying between 1433-2000+ MPa and depths from 44-62+ km. One mafic sample has 43.3% SiO2 with 2000+ MPa and 62+ km depth. Intermediate magmas vary from 63.5% - 67.47% SiO2 with pressures ranging from 508-1527 MPa and depths of 19.2-42.5 km. The felsic magmas range from 71.1% -78.36% SiO2, with pressures varying between 50-521 MPa and depths from 1.9-19.2 km. Harker Diagrams show discontinuity amongst the various compositions. Spatial and geochemical relationships show that there are two areas where mafic magma has erupted: N37.8381 and between N37.9036 - N37.908. Intermediate magmas span a wider range of latitude: N37.8297 - N37.8373 and N37.9018 - N37.9048. Felsic magmas derive from every dome in the Mono Craters system. Mafic magmas, in contrast, derive from just two areas underneath the Mono Craters. We conclude that there are at least two main feeder systems into the Mono Craters magmatic plumbing system, which disperse into a more diffuse system within the lower crust, before being further dispersed at very

  1. Beneficios de la terapia cognitivo-conductual y la presoterapia en pacientes obesos: ensayo clínico aleatorizado Benefits of cognitive behavior therapy and acupressure therapy in obese patients: a randomized clinical trial

    Directory of Open Access Journals (Sweden)

    V. Torres

    2011-10-01

    Full Text Available Objetivo: el objetivo del presente trabajo fue analizar la modificación de los hábitos de vida en pacientes obesos mediante la terapia cognitivo-conductual administrada conjuntamente con la presoterapia. Métodos: Se realizó un estudio experimental con grupo control placebo. Se asignaron de forma aleatoria 40 pacientes a grupo de intervención (terapia cognitivo-conductual + presoterapia y a grupo control (sesiones informativas. La dimensión de estudio fue la administración de un cuestionario sobre valoración y cuantificación de los hábitos de vida relacionados con la obesidad. Las evaluaciones se realizaron en el momento basal y al finalizar los 3 meses de intervención. Resultados: Finalizados los 3 meses de tratamiento, en el grupo de intervención se obtuvieron diferencias significativas (p Objective: The purpose of this study was to analyze change of lifestyle in obese patients with cognitive behavior therapy and acupressure. Methods: An experimental study was performed with placebo control group. Forty patients were randomly assigned to intervention group (cognitive behaviour therapy + acupressure and control group (information session. Outcome measure was a questionnaire for the assessment and quantification of obesity related lifestyles. Measures were performed at baseline and, after 3-months intervention. Results: After 3 months of treatment, the intervention group showed significant differences (p < 0.05 in weight loss, diet and physical activity. Conclusion: In the obese patient, cognitive behavior therapy and acupressure, it has lost at least three kilograms over three months and has changed lifestyles related to obesity.

  2. New mono-organotin (IV) dithiocarbamate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi (Malaysia)

    2014-09-03

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S{sub 2}CNR′R″]{sub 2} (R= Ph, CH{sub 3}, R′ = CH{sub 3}, C{sub 2}H{sub 5}, C{sub 7}H{sub 7} and R″ = C{sub 2}H{sub 5}, C{sub 6}H{sub 11}, iC{sub 3}H{sub 7}, C{sub 7}H{sub 7}). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, {sup 1}H, {sup 13}C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm{sup −1} respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The {sup 13}C NMR spectra showed an important shift for δ(N{sup 13}CS{sub 2}) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S{sub 2}CN(Et)(i−Pr)]{sub 2}, MeSnCl[S{sub 2}CN(Me)(Cy)]{sub 2} and MeSnCl[S{sub 2}CN(i−Pr)(CH{sub 2}Ph)]{sub 2}. All structures having a distorted octahedral geometry set by CClS{sub 4} donor atom from the two

  3. Pairing preferences of the model mono-valence mono-atomic ions investigated by molecular simulation.

    Science.gov (United States)

    Zhang, Qiang; Zhang, Ruiting; Zhao, Ying; Li, HuanHuan; Gao, Yi Qin; Zhuang, Wei

    2014-05-14

    We carried out a series of potential of mean force calculations to study the pairing preferences of a series of model mono-atomic 1:1 ions with evenly varied sizes. The probabilities of forming the contact ion pair (CIP) and the single water separate ion pair (SIP) were presented in the two-dimensional plots with respect to the ion sizes. The pairing preferences reflected in these plots largely agree with the empirical rule of matching ion sizes in the small and big size regions. In the region that the ion sizes are close to the size of the water molecule; however, a significant deviation from this conventional rule is observed. Our further analysis indicated that this deviation originates from the competition between CIP and the water bridging SIP state. The competition is mainly an enthalpy modulated phenomenon in which the existing of the water bridging plays a significant role.

  4. CORRELAÇÕES DA IMPRESSÃO PLANTAR COM DISFUNÇÕES BIOMECÂNICAS CRÂNIO CERVICAIS E EM MEMBROS INFERIORES EM ADOLESCENTES OBESOS

    Directory of Open Access Journals (Sweden)

    Liana Cardoso Andrade

    2012-06-01

    Full Text Available Introdução: Alteração a nível corporal do indivíduo como a obesidade, se não ocorrer fenômenos adaptativos eficientes, gerados pelo próprio organismo, pode ter graves consequências de distúrbios posturais. Objetivo: Analisar o padrão postural de adolescentes obesos através da biofotogrametria em escola pública de Teresina-PI. Metodologia: A amostra foi composta de 88 adolescentes (10-14anos categorizados em grupo controle GC (n=33, grupo sobrepeso-GS (n=24 e grupo Obeso-GO (n=31. Os escolares foram posicionados e fotografados em posição ortostática frontal anterior, sagital direita e posterior. As pressões plantares foram registradas em um podoscópio. Realizou-se avaliação postural utilizando programa Corew Draw 12 baseado no princípio da fotogrametria. Resultados: A incidência de sobrepeso e obesidade foi de 41, 67 e 67,74% no sexo masculino e 58,33% e 32,26% no sexo feminino. A maior incidência de alterações posturais entre adolescentes GO e GS com pConclusão: A obesidade em adolescentes pode levar a alterações posturais. Palavras-chave: Obesidade. Impressões Plantares. Postura.

  5. Degenerate gaugino mass region and mono-boson collider signatures

    CERN Document Server

    Anandakrishnan, Archana; Raby, Stuart

    2014-01-01

    In this paper we discuss search strategies at the LHC for light electroweak gauginos which are mostly Wino-like, Higgsino-like or an admixture. These states are typically degenerate with decay products that are less energetic and hence difficult to detect. In addition, their production cross-sections at a hadron collider are suppressed compared to colored states such as the gluinos. In order to detect these states one needs to trigger on initial or final state radiation. Many previous analyses have focussed on mono-jet and mono-photon triggers. In the paper we argue and show that these triggers are unlikely to succeed, due to the large background from QCD backgrounds for the mono-jet searches and the fact that the $p_T$ distribution of the mono-photons are rapidly decreasing functions of $p_T$. We show this with both an analytic calculation of photons in the initial state radiation and also a detailed numerical analysis. We then argue that mono-Z triggers, from Z decaying into charged leptons may well provide...

  6. As principais alterações dermatológicas em pacientes obesos Major dermatological changes in obese patients

    Directory of Open Access Journals (Sweden)

    Rosimeri da Silva Castanho Mendonça

    2011-03-01

    Full Text Available INTRODUÇÃO: A obesidade é considerada grave doença crônica que vem atingindo proporções mundiais gerando transtornos sérios para a saúde pública. No Brasil, a prevalência desta doença denota aumento progressivo em relação ao número de pessoas com sobrepeso e/ou obesidade. Apesar disso, as manifestações dermatológicas da obesidade têm sido pouco estudadas. OBJETIVO: Abordar as dermatoses que mais acometem pacientes obesos e seu tratamento, principalmente na aplicação adequada da fisioterapia dermatofuncional. MÉTODO: Revisão da literatura, entre 2000 e 2010, de artigos indexados nas bases Medline/Pubmed, Scielo e Lilacs, livros e monografias das bibliotecas da Universidade de Fortaleza e Universidade Federal do Ceará, Fortaleza, CE, Brasil, cruzando os descritores obesidade, dermatose e fisioterapia. Foram reconhecidas como mais importantes as seguintes situações patológicas: estrias, celulite, acanthosis nigricans, acrocórdons, flacidez, úlcera e impetigo. Entre as formas de tratamento deuse destaque à atuação da fisioterapia dermatofuncional. CONCLUSÃO: O tratamento das dermatoses por meio da fisioterapia dermatofuncional é possível podendo trazer consigo resultados que satisfaçam a expectativa dos pacientes e proporcionando-lhes melhor qualidade de vida.INTRODUCTION: Obesity is a serious chronic disease that has reached global proportions causing problems to public health. In Brazil, the prevalence of this disease shows a progressive increase in the number of people with overweight or obesity. Nevertheless, the skin manifestations have not been well studied. OBJECTIVE: To analyse the dermatosis most affecting obese patients and its treatment, particularly in proper application of dermatological therapy. METHOD: Was made a literature review between 2000 and 2010 of articles published in Medline/ PubMed, SciELO and Lilacs, books and monographs of the libraries of the University of Fortaleza and the Federal

  7. Extraction of mono- and dicarboxylic acids from a curative water.

    Science.gov (United States)

    Franke, C; Weil, L; Niessner, R

    1995-09-01

    A method for the analysis of mono- and dicarboxylic acids from water is presented. For this purpose two techniques, a C(18) solid phase extraction (SPE) and a combination method of liquid-liquid extraction (LLE) and aminopropyl SPE, were tested. With the combination method all analytes, short-chain mono- and long-chain dicarboxylic acids, could be analysed in one approach. The C(18) SPE was not suitable for short-chain mono- but for dicarboxylic acids. Concentrations in the investigated water ranged from 315 mg/l (butanoic acid) to 2.9 mg/l (octanoic acid). Dicarboxylic acids were found from 5 mg/l (octanedioic acid) to 0.5 mg/l (dodecanedioic acid).

  8. Fatigue Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed thro...... of the natural period, damping ratio, current, stress Spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower.......In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...

  9. Fatigue Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    1991-01-01

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed thro...... of the natural period, damping ratio, current, stress spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower.......In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...

  10. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard;

    In this paper a reliability analysis of a Mono-tower platform is presented. The failure modes, considered, are yelding in the tube cross-sections, and fatigue failure in the butt welds. The fatigue failure mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...... for the fatigue limit state is a significant failure mode for the Mono.tower platform. Further, it is shown for the fatigue failure mode the the largest contributions to the overall uncertainty are due to the damping ratio, the inertia coefficient, the stress concentration factor, the model uncertainties...

  11. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard;

    1990-01-01

    In this paper, a reliability analysis of a Mono-tower platform is presented. Te failure modes considered are yielding in the tube cross sections and fatigue failure in the butts welds. The fatigue failrue mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...... that the fatigue limit state is a significant failure mode for the Mono-tower platform. Further, it is shown for the fatigue failure mode that the largest contributions to the overall uncertainty are due to the damping ratio, the inertia coefficient, the stress concentration factor, the model uncertainties...

  12. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

    2015-01-01

    No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution for inno......No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution...

  13. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    Full Text Available FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo Modelo de Avaliação da Homeostase (HOMA-RI: com resistência insulínica (RI n = 39 e sem resistência insulínica (NRI n = 27, e foram submetidos a uma intervenção interdisciplinar ao longo de um ano. A espessura mediointimal da artéria carótida comum (EMIC, e o tecido adiposo visceral e subcutâneo foram determinados por ultrassonografia. A composição corporal, pressão arterial, índice HOMA-RI, perfil lipídico e as concentrações de adipocinas [leptina, adiponectina, e inibidor do ativador do plasminogênio-1 (PAI-1] foram analisados antes e após a terapia. RESULTADOS: Ambos os grupos apresentaram melhoras significativas na composição corporal, estado inflamatório (redução da concentração de leptina e PAI 1; aumento de adiponectina plasmática e redução da EMIC. Apenas o grupo NRI mostrou correlação positiva entre as alterações na gordura visceral (∆Visceral e mudanças na EMIC (∆ EMIC (r = 0,42, p < 0,05. A análise por regressão linear simples revelou o ∆Visceral ser um preditor independente para a redução da EMIC nesse grupo (R2 ajustado = 0,14, p = 0,04. Os valores finais da EIMC permaneceram significativamente maiores no grupo RI, quando comparado com grupo NRI. CONCLUSÃO: A presença de resistência insulínica pode prejudicar mudanças na EMIC levando ao desenvolvimento precoce da aterosclerose em adolescentes obesos submetidos a uma intervenção interdisciplinar.

  14. Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats

    Directory of Open Access Journals (Sweden)

    Ana Paula Lima-Leopoldo

    2011-09-01

    Full Text Available FUNDAMENTO: Vários mecanismos têm sido propostos contribuir para a disfunção cardíaca em modelos de obesidade, tais como alterações nas proteínas do trânsito de cálcio (Ca+2 e nos receptores beta-adrenérgicos. Todavia, o papel desses fatores no desenvolvimento da disfunção miocárdica induzida pela obesidade ainda não está claro. OBJETIVO: Este estudo pretende investigar se a obesidade induzida por um ciclo de dieta hipercalóricas resulta em disfunção cardíaca. Além disso, foi avaliado se essa alteração funcional em ratos obesos está relacionada com o prejuízo do trânsito de Ca+2 e do sistema beta-adrenérgico. MÉTODOS: Ratos Wistar machos, 30 dias de idade, foram alimentados com ração padrão (C e um ciclo de cinco dietas hipercalóricas (Ob por 15 semanas. A obesidade foi definida pelo aumento da porcentagem de gordura corporal dos ratos. A função cardíaca foi avaliada mediante análise isolada do músculo papilar do ventrículo esquerdo em condições basais e após manobras inotrópicas e lusitrópicas. RESULTADOS: Em comparação com o grupo controle, os ratos obesos apresentaram aumento da gordura corporal e intolerância a glicose. Os músculos dos ratos obesos desenvolveram valores basais semelhantes; entretanto, as respostas miocárdicas ao potencial pós-pausa e aumento de Ca+2 extracelular foram comprometidas. Não houve alterações na função cardíaca entre os grupos após a estimulação beta-adrenérgica. CONCLUSÃO: A obesidade promove disfunção cardíaca relacionada com alterações no trânsito de Ca+2 intracelular. Esse prejuízo funcional é provavelmente ocasionado pela redução da atividade da bomba de Ca+2 do retículo sarcoplasmático (SERCA2a via Ca+2 calmodulina-quinase.BACKGROUND: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+ handling proteins and β-adrenergic receptors. Nevertheless, the role of

  15. Spin, Charge, and Bonding in Transition Metal Mono Silicides

    NARCIS (Netherlands)

    Marel, D. van der; Damascelli, A.; Schulte, K.; Menovsky, A. A.

    1997-01-01

    Published in: Physica B 244 (1998) 138-147 citations recorded in [Science Citation Index] Abstract: We review some of the relevant physical properties of the transition metal mono-silicides with the FeSi structure (CrSi, MnSi, FeSi, CoSi, NiSi, etc) and explore the relation between their structural

  16. Temperature dependence of atomic vibrations in mono-layer graphene

    NARCIS (Netherlands)

    Allen, C.S.; Liberti, E.; Kim, J.S.; Xu, Q.; Fan, Y.; He, K.; Robertson, A.W.; Zandbergen, H.W.; Warner, J.H.; Kirkland, A.I.

    2015-01-01

    We have measured the mean square amplitude of both in- and out-of-plane lattice vibrations for mono-layer graphene at temperatures ranging from ∼100 K to 1300 K. The amplitude of lattice vibrations was calculated from data extracted from selected area electron diffraction patterns recorded across a

  17. 21 CFR 184.1505 - Mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... prepared from fats or oils or fat-forming acids that are derived from edible sources. The most prevalent fatty acids include lauric, linoleic, myristic, oleic, palmitic, and stearic. Mono- and diglycerides are manufactured by the reaction of glycerin with fatty acids or the reaction of glycerin with triglycerides in...

  18. Tagging a mono-top signature in Natural SUSY

    CERN Document Server

    Goncalves, Dorival; Takeuchi, Michihisa

    2016-01-01

    We study the feasibility of probing a region of Natural Supersymmetry where the stop and higgsino masses are compressed. Although this region is most effectively searched for in the mono-jet channel, this signature is present in many other non-supersymmetric frameworks. Therefore, another channel that carries orthogonal information is required to confirm the existence of the light stop and higgsinos. We show that a supersymmetric version of the $t \\bar t H$ process, $pp \\to t \\tilde t_1 \\tilde \\chi^0_{1(2)}$, can have observably large rate when both the stop and higgsinos are significantly light, and it leads to a distinctive mono-top signature in the compressed mass region. We demonstrate that the hadronic channel of the mono-top signature can effectively discriminate the signal from backgrounds by tagging a hadronic top-jet. We show that the hadronic channel of mono-top signature offers a significant improvement over the leptonic channel and the sensitivity reaches $m_{\\tilde t_1} \\simeq 420$ GeV at the 13 ...

  19. Variabilidade da frequência cardíaca, lípides e capacidade física de crianças obesas e não-obesas Variabilidad de la frecuencia cardiaca, lípidos y capacidad física de niños obesos y no obesos Heart rate variability, blood lipids and physical capacity of obese and non-obese children

    Directory of Open Access Journals (Sweden)

    Mário Augusto Paschoal

    2009-09-01

    Full Text Available FUNDAMENTO: A obesidade pode afetar a modulação autonômica cardíaca, os lípides do sangue e a capacidade física. OBJETIVO: Estudar a interferência da obesidade sobre a variabilidade da frequência cardíaca (VFC, os lípides do sangue e a capacidade física de crianças obesas. MÉTODOS: Foram estudadas 30 crianças com idades entre 9 a 11 anos, divididas em dois grupos: a 15 crianças obesas (O com 10,2 ± 0,7 anos de idade e índice de massa corporal (IMC no percentil entre 95 e 97; b 15 crianças não-obesas (NO com 9,8 ± 0,7 anos de idade e IMC no percentil entre 5 e 85. Todas foram submetidas a avaliação antropométrica e clínica, análise da VFC ao repouso e a um protocolo de esforço (PE. Utilizaram-se testes não-paramétricos para comparar as variáveis entre os grupos, e o nível de significância aplicado foi de p FUNDAMENTO: La obesidad puede afectar la modulación autonómica cardiaca, los lípidos de la sangre y la capacidad física. OBJETIVO: Estudiar la interferencia de la obesidad sobre la variabilidad de la frecuencia cardiaca (VFC, los lípidos de la sangre y la capacidad física de niños obesos. MÉTODOS: Se estudiaron a 30 niños con edades entre 9 y 11 años, divididos en dos grupos: a 15 niños obesos (O con 10,2 ± 0,7 años de edad e índice de masa corporal (IMC en el percentil entre 95 y 97; b 15 niños no obesos (NO con 9,8 ± 0,7 años de edad e IMC en el percentil entre 5 y 85. Todos se sometieron a evaluación antropométrica y clínica, análisis de la VFC al reposo y a un protocolo de esfuerzo (PE. Se utilizaron pruebas no paramétricas para comparar las variables entre los grupos, y el nivel de significancia aplicado fue de p BACKGROUND: Obesity can affect the cardiac autonomic modulation, blood lipid levels and the physical capacity. OBJECTIVE: To study the effect of obesity on the heart rate variability (HRV, blood lipid levels and physical capacity of obese children. METHODS: Thirty children aged

  20. Ensayo clínico aleatorizado con una galleta enriquecida en inulina en el patrón de riesgo cardiovascular de pacientes obesos Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2010-02-01

    Full Text Available Introducción: La inulina es un prebiótico con potenciales efectos beneficiosos a nivel cardiovascular. El objetivo de nuestro trabajo es evaluar la respuesta del perfil de riesgo cardiovascular en pacientes obesos tras la inclusión en la dieta de una galleta enriquecida en inulina. Material y métodos: Un total de 34 pacientes fueron randomizados a una de las siguientes ramas: galleta I (enriquecida con inulina, ver tabla I y galleta II (galleta control, ver tabla I (Gullón SL. Cada paciente recibió un total de 8 galletas al día (total de 68 gramos de producto. Antes de iniciar el tratamiento y al mes se realizóuna valoración nutricional y analítica. Resultados: Finalizaron un total de 15 pacientes en cada grupo. En el grupo I se produjo un aumento significativo en la ingesta de fibra soluble (inulina. Se detectó en los pacientes con las galletas enriquecidas en inulina una disminución significativa de los niveles de colesterol total (223,1 ± 45,3 mg/dl vs 208,8 ± 33,1 mg/dl; p Introduction: Inulin is a prebiotic with potential benefit in cardiovascular risk factors. The aim of our work is to evaluate in obese patients the effect of a inulin enriched cookie on cardiovascular risk factors. Material and methods: 34 patients were randomized in both branches: group I (inulin enriched cookie Gullon SL® and group II (control cookie. Previous and after 1 month of the treatment, a nutritional and biochemical study was realized. Results: 15 patients finished the procotol in each group. In group I, an increase in soluble fiber intake (inulin was detected. In this group a significant decrease of total cholesterol (223.1 ± 45.3 mg/dl vs 208.8 ± 33.1 mg/dl; p < 0.05 and LDL cholesterol (142.9 ± 39.2 mg/dl vs 131.4 ± 28.6 mg/dl; p < 0.05 was reached. A non significant improvement in insulin levels and HOMA was detected in inulin-enriched cookie group, too. Anthropometric parameters did not change in both groups. The increase in soluble fiber

  1. Consumo alimentar e gasto energético em adolescentes obesos e eutróficos Food consumption and energy expenditure in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Camila Dayrell

    2009-12-01

    Full Text Available OBJETIVO: Comparar, entre adolescentes obesos e eutróficos, variáveis relacionadas ao consumo alimentar e ao gasto energético. MÉTODOS: Estudo transversal com 23 adolescentes recrutados em escolas e centros de recreação de São Paulo (SP, distribuídos em dois grupos: 11 obesos e 12 eutróficos. Foram avaliados: peso corporal, estatura, índice de massa corporal, circunferência da cintura, massa magra e massa gorda (estimados por bioimpedância elétrica, três recordatórios alimentares de 24 horas, estimativa do gasto energético diário a partir de três métodos (recordatórios de atividade física, fórmulas preditivas e calorimetria indireta, gasto energético de repouso e a potência aeróbia. RESULTADOS: O gasto energético diário dos obesos foi maior, porém a ingestão alimentar se assemelhou à dos eutróficos. Não foram encontradas diferenças no gasto energético de repouso entre os grupos, porém a potência aeróbia foi maior nos eutróficos. A dieta de ambos os grupos não foi considerada saudável, mas os obesos apresentaram menor consumo de vários alimentos considerados saudáveis, como hortaliças. Observou-se discrepância na análise do gasto energético diário, quando se adotaram diferentes métodos. CONCLUSÕES: Os adolescentes apresentaram padrão alimentar associado ao risco de obesidade e doenças crônicas. Mais estudos são necessários para identificar melhores métodos para avaliar seu gasto energético. É urgente a busca de estratégias de educação nutricional específicas para esse grupo etário.OBJECTIVE: To compare food consumption and energy expenditure between obese and non-obese adolescents. METHODS: This cross-sectional study comprised 23 adolescents recruited from schools and recreation centers from São Paulo (SP, Brazil, distributed in two groups: 11 obese and 12 non-obese. The following variables were analyzed: body weight, height, body mass index, waist circumference, fat and lean mass

  2. Efeitos do exercício físico na resistência à insulina em indivíduos obesos

    OpenAIRE

    Robson Rezende; Camila Santos; Camila Dubow; Sheila Cristina Vargas; Hildegard Hedwig Pohl; Dulciane Nunes Paiva

    2016-01-01

    A obesidade apresenta consequências negativas na sensibilidade à insulina, sendo necessário compreender os mecanismos que estão associados aos benefícios oferecidos pelo exercício físico, como forma, tanto de prevenção, como de tratamento de doenças e transtornos metabólicos. Objetivo: descrever os efeitos do exercício físico na resistência à insulina em indivíduos obesos. Método: realizou-se uma revisão da literatura, tendo como fontes artigos publicados em periódicos nacionais e internacion...

  3. Influência do treinamento aeróbio e anaeróbio na massa de gordura corporal de adolescentes obesos

    OpenAIRE

    Fernandez, Ana Cláudia [UNIFESP; Mello,Marco Túlio De; Tufik, Sérgio; Castro,Paula Morcelli de; Fisberg, Mauro

    2004-01-01

    O objetivo deste estudo foi verificar as influências do exercício aeróbio e anaeróbio na composição corporal de adolescentes obesos do sexo masculino. A amostra foi constituída de 28 adolescentes com idades entre 15 e 19 anos, que apresentavam obesidade grave. Os voluntários foram distribuídos aleatoriamente em três grupos: grupo I: exercício anaeróbio; grupo II: exercício aeróbio; e grupo III: controle. O grupo I realizou treinamento intervalado em cicloergômetro que consistiu de 12 "tiros" ...

  4. Dissecting simulated disk galaxies I: the structure of mono-age populations

    CERN Document Server

    Martig, Marie; Flynn, Chris

    2014-01-01

    We study seven simulated disk galaxies, three with a quiescent merger history, and four with mergers in their last 9 Gyr of evolution. We compare their structure at z=0 by decomposing them into "mono-age populations" (MAPs) of stars within 500 Myr age bins. All studied galaxies undergo a phase of merging activity at high redshift, so that stars older than 9 Gyr are found in a centrally concentrated component, while younger stars are mostly found in disks. We find that most MAPs have simple exponential radial and vertical density profiles, with a scale-height that typically increases with age. Because a large range of merger histories can create populations with simple structures, this suggests that the simplicity of the structure of mono-abundance populations observed in the Milky Way by Bovy et al. (2012b,c) is not necessarily a direct indicator of a quiescent history for the Milky Way. Similarly, the anti-correlation between scale-length and scale-height does not necessarily imply a merger-free history. How...

  5. Pyrogen testing of lipid-based TPN using Mono Mac 6 monocyte cell line and DELFIA

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    1997-01-01

    Measurement of lipopolysaccharide (LPS) induced interleukin-6 (IL-6) secretion in Mono Mac 6 cells.......Measurement of lipopolysaccharide (LPS) induced interleukin-6 (IL-6) secretion in Mono Mac 6 cells....

  6. 21 CFR 573.800 - Polyethylene glycol (400) mono- and dioleate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Polyethylene glycol (400) mono- and dioleate. 573... DRINKING WATER OF ANIMALS Food Additive Listing § 573.800 Polyethylene glycol (400) mono- and dioleate. (a) The food additive polyethylene glycol (400) mono- and dioleate meets the following...

  7. 21 CFR 172.856 - Propylene glycol mono- and diesters of fats and fatty acids.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Propylene glycol mono- and diesters of fats and... DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Multipurpose Additives § 172.856 Propylene glycol mono- and diesters of fats and fatty acids. Propylene glycol mono- and diesters of fats and fatty acids may be...

  8. 40 CFR 721.8340 - Mono esters from 2- propenoic acid (generic).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mono esters from 2- propenoic acid... Specific Chemical Substances § 721.8340 Mono esters from 2- propenoic acid (generic). (a) Chemical... as mono esters from 2-propenoic acid (PMN P-01-85) is subject to reporting under this section for...

  9. 21 CFR 184.1101 - Diacetyl tartaric acid esters of mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Diacetyl tartaric acid esters of mono- and... acid esters of mono- and diglycerides. (a) Diacetyl tartaric acid esters of mono- and diglycerides, also know as DATEM, are composed of mixed esters of glycerin in which one or more of the...

  10. Padrões alimentares de adolescentes obesos e diferentes repercussões metabólicas Dietary patterns of obese adolescents and different metabolic effects

    Directory of Open Access Journals (Sweden)

    Vera Regina Mello Dishchekenian

    2011-02-01

    Full Text Available OBJETIVO: Avaliar a associação de padrões alimentares com alterações metabólicas em adolescentes obesos. MÉTODOS: Estudo transversal envolvendo 76 estudantes (ambos os sexos, 14-19 anos, IMC³P95 e Tanner ³4 de escolas públicas da cidade de São Paulo, Brasil. Foram coletados dados antropométricos e bioquímicos, e aplicados questionários com informações sociodemográficas e registro alimentar de 4 dias, entre 2006 e 2007. Escores fatoriais foram obtidos na análise fatorial e, após ajustes, três padrões alimentares identificados foram associados a fatores de risco biológico por regressão linear múltipla. RESULTADOS: O padrão Tradicional (arroz e massas, feijões, carnes vermelhas, embutidos, óleos e doces foi positivamente associado com insulina, glicemia e triglicérides e negativamente associado com lipoproteína de alta densidade. O padrão Em Transição (peixe, aves, ovos, pães, manteiga, leite e derivados, hortaliças, frutas, sucos de frutas e açúcar refinado apresentou as mesmas associações, além de associação similar com a pressão arterial diastólica. O padrão Fast Food (cafeteria, hambúrguer, maionese, bolacha, bolos e tortas, chocolate e refrigerantes apresentou associação positiva com o colesterol, lipoproteína de baixa densidade e pressão arterial sistólica e diastólica, e associação negativa com insulina e lipoproteína de alta densidade. CONCLUSÃO: Os padrões Tradicional e Em transição apresentaram associações diferentes com o metabolismo lipídico e glicídico quando comparados com o padrão Fast Food. Os três padrões podem ser considerados obesogênicos, porém o padrão Fast Food pareceu ser o mais aterogênico e promotor de hipertensão arterial.OBJECTIVE: This study assessed the association between dietary patterns and metabolic changes in obese adolescents. METHODS: This was a cross-sectional study of 76 students (both genders, 14-19 years old, BMI³P95 and Tanner stage ³4

  11. Accelerating mono-domain cardiac electrophysiology simulations using OpenCL

    Directory of Open Access Journals (Sweden)

    Wülfers Eike M.

    2015-09-01

    Full Text Available Using OpenCL, we developed a cross-platform software to compute electrical excitation conduction in cardiac tissue. OpenCL allowed the software to run parallelized and on different computing devices (e.g., CPUs and GPUs. We used the macroscopic mono-domain model for excitation conduction and an atrial myocyte model by Courtemanche et al. for ionic currents. On a CPU with 12 HyperThreading-enabled Intel Xeon 2.7 GHz cores, we achieved a speed-up of simulations by a factor of 1.6 against existing software that uses OpenMPI. On two high-end AMD FirePro D700 GPUs the OpenCL software ran 2.4 times faster than the OpenMPI implementation. The more nodes the discretized simulation domain contained, the higher speed-ups were achieved.

  12. Multiple isomers in the photoelectron spectra of small mono-niobium carbide clusters

    Science.gov (United States)

    Iordanov, Ivan; Sofo, Jorge O.

    2011-05-01

    We calculate the photoelectron spectrum of small mono-niobium carbide clusters (NbCn) using density functional theory for clusters with n = 2-7 and the symmetry adapted cluster configuration interaction method for the smallest clusters (n = 2-4). Theoretical spectra of a single structure cannot explain all peaks present in the spectrum measured by Zhai et al. [J. Chem. Phys. 115, 5170 (2001)]. However, we can match all peaks in the experimental spectra if we assume that the beam contains a combination of cyclic and linear structures. This finding is even more surprising given the fact that some of the excited metastable geometries have energies as large as 0.5 eV above the ground state. Our result is confirmed by both theoretical approaches. We suggest further experiments, using additional beam cooling, to corroborate this observation.

  13. Respuesta al tratamiento periodontal de diabéticos tipo 2 con mal control metabólico y obesos intolerantes a la glucosa, con periodontitis severa

    OpenAIRE

    V Pavez Correa; Araya Quintanilla,A V; López N,Baksai

    2011-01-01

    Diabetes Mellitus (DM) es un factor de riesgo para periodontitis, a su vez, el control metabólico de los diabéticos se dificulta por la presencia de la infección periodontal, aumentando el riesgo de complicaciones crónicas y eventualmente, la mortalidad por diabetes. Ambas enfermedades se relacionan porque los mediadores de inflamación generados en la infección periodontal y la translocación de bacterias de la cavidad oral a la circulación sistémica, podrían actuar como agravantes de la insul...

  14. Permeability of mono- and bi-dispersed porous media

    Directory of Open Access Journals (Sweden)

    Kim S.J.

    2013-04-01

    Full Text Available In this study, the permeability of mono- and bi-dispersed porous media is considered. The effects of the particle size distribution and the packing structure of particles on the permeability are investigated experimentally and analytically. Both experimental and analytic results suggest that the particlesize distribution is close to the log-normal distribution, and the permeability of the mono-dispersed porous media quasi-linearly decreases as the range of the particle size distribution increases. On the other hand, the effect of packing structure of particles on the permeability is shown to be negligible.The permeability of the bidispersed porous media quasi-linearly decreases as the range of cluster size increases, and nearly independent of the particle size distribution. The present model is valid over the range of parameters typically found in heat transfer applications.

  15. Mono Lake Analog Mars Sample Return Expedition for AMASE

    Science.gov (United States)

    Conrad, P. G.; Steele, A.; Younse, P.; DiCicco, M.; Morgan, A. R.; Backes, P.; Eigenbrode, J. E.; Marquardt, D.; Amundsen, H. E. F.

    2011-01-01

    We explored the performance of one robotic prototype for sample acquisition and caching of martian materials that has been developed at the Jet Propulsion Laboratory for potential use in the proposed MAX-C Mars Sample Return architecture in an environment, rich in chemical diversity with a variety of mineralogical textures. Mono Lake State Tufa Reserve in Mono County, CA possesses a variety of minerals including a variety of evaporites, volcanic glass and lava, and sand and mudstones. The lake itself is an interesting chemical system: the water is highly alkaline (pH is approximately 10) and contains concentrations of Cl, K, B, with lesser amounts of S Ca Mg, F, As, Li, I and Wand generally enriched HREEs. There are also traces of radioactive elements U, Th, Pl.

  16. Assessment of executive functions in obese individuals with binge eating disorder Avaliação de funções executivas em indivíduos obesos com transtorno da compulsão alimentar periódica

    Directory of Open Access Journals (Sweden)

    Duchesne Monica

    2010-12-01

    Full Text Available OBJECTIVE: The aim of this study was to assess executive functions of obese individuals with binge eating disorder. METHOD: Thirty-eight obese individuals with binge eating disorder were compared to thirty-eight obese controls without binge eating disorder in terms of their executive functions. All individuals were assessed using the following instruments: Digit Span, Trail Making Tests A and B, Stroop Test and the Wisconsin Card Sorting Test. In addition, four subtests from the Behavioral Assessment of the Dysexecutive Syndrome Battery were also used, namely the Zoo Map Test, the Modified Six Elements Test, the Action Program Test and the Rule Shift Cards Test. RESULTS: When compared to obese controls, obese individuals with binge eating disorder presented significant impairment in the following tests: Digit Span backward, Zoo Map Test, Modified Six Elements Test, and Action Program Test. Subjects with binge eating disorder also showed significant more set shifting and perseverative errors in the Wisconsin Card Sorting Test. In other measures such as the Digit Span Forward, the Trail Making Test, the Stroop Test and the Rule Shift Cards Test, obese subjects with binge eating disorder did not differ significantly from obese subjects without binge eating disorder. CONCLUSION: These results suggest that, in the present sample, obese individuals with binge eating disorder presented executive deficits, especially impairments relating to problem-solving, cognitive flexibility and working memory.OBJETIVO: O objetivo desse estudo foi avaliar as funções executivas de indivíduos obesos com transtorno da compulsão alimentar periódica. MÉTODO: Trinta e oito indivíduos obesos com transtorno da compulsão alimentar periódica foram comparados com 38 controles obesos sem transtorno da compulsão alimentar periódica em termos de suas funções executivas. Todos os indivíduos foram avaliados utilizando os seguintes instrumentos: Digit Span, Trail

  17. Efeito do treinamento aeróbio e do treinamento anaeróbio na expressão de citocinas e de transportador de glicose GLUT4 no tecido muscular esquelético de ratos obesos

    OpenAIRE

    2010-01-01

    Durante a obesidade ocorre aumento de ácidos graxos livres na circulação e, conseqüentemente aumento do conteúdo de proteínas com efeitos negativos na sinalização da insulina. Objetivo: Avaliar o efeito do treinamento aeróbio na modulação de RNAm de GLUT4, TNF-a e SOCS3 em tecidos musculares esqueléticos e a sensibilidade à insulina periférica de ratos obesos por dieta hiperlipídica. Métodos: Ratos obesos por dieta hiperlipídica foram submetidos ao protocolo de treinamento aeróbio. A sensibil...

  18. Índice glicêmico e carga glicêmica de dietas consumidas por indivíduos obesos Glycemic index and glycemic load of diets consumed by obese individuals

    OpenAIRE

    Helena Alves de Carvalho Sampaio; Bruna Yhang da Costa Silva; Maria Olganê Dantas Sabry; Paulo César de Almeida

    2007-01-01

    OBJETIVO: Avaliar o índice glicêmico e a carga glicêmica de dietas de indivíduos obesos. MÉTODOS: Trata-se de estudo retrospectivo, que analisou as fichas clínicas de 80 adultos obesos, acompanhados em um serviço privado localizado em Fortaleza, Ceará. Determinaram-se o índice glicêmico e a carga glicêmica da dieta. Para verificação da associação entre índice glicêmico e carga glicêmica, e dessas variáveis com a ingestão energética diária e com o índice de massa corporal dos indivíduos, utili...

  19. Obesos diabéticos tipo 2 submetidos à derivação gástrica em Y-de-Roux: análise de resultados e influência nas complicações

    OpenAIRE

    Zeve, Jorge Luiz de Mattos; Tomaz, Carlos Alberto Bezerra; NASSIF, Paulo Afonso Nunes; Lima, João Henrique de; Sansana,Luciana Regina Zeve; Zeve,Christiana Haddad

    2013-01-01

    RACIONAL: Cerca de 90% dos diabéticos tipo 2 são obesos ou têm sobrepeso. A evidente melhora clínica observada com o tratamento cirúrgico, como a derivação gástrica em Y-de-Roux, abriu caminhos para a pesquisa de outros fatores, que não somente a perda de peso, como responsáveis pelo retorno à euglicemia ou redução no tratamento medicamentoso. OBJETIVO: Avaliar a eficácia e segurança do tratamento cirúrgico do diabete melito em obesos com IMC acima de 35 Kg/m2 submetidos ao by-pass visando o ...

  20. Impacto de la educación participativa en el índice de masa corporal y glicemia en individuos obesos con diabetes tipo 2 Impact of participatory education on body mass index and blood glucose in obese type-2 diabetics

    Directory of Open Access Journals (Sweden)

    Carlos Enrique Cabrera-Pivaral

    2004-02-01

    Full Text Available La obesidad eleva el riesgo de morbilidad y mortalidad y se ha relacionado con los hábitos alimentarios y estos con la educación en salud. Esta última tiene como propósito promover la participación de los enfermos en mejorar los comportamientos humanos y estilos de vida saludables y mostrar las ventajas de la educación participativa en la modificación del Índice de Masa Corporal (IMC en el diabético obeso tipo 2. Se realizó un estudio cuasi experimental con asignación aleatoria de dos grupos de pacientes diabéticos obesos. La intervención educativa-participativa se organizó mediante el proceso de reflexión-acción. Se efectuaron mediciones del IMC basal y mensuales durante los 9 meses de la intervención educativa. Los grupos fueron controlados tomando en cuenta edad y sexo. El análisis estadístico se efectuó con el estadígrafo de t de students con diferencia de media para grupos relacionados. El grupo control logra un valor promedio de IMC basal de 33.89 ± 1.96 y al final de 33.2 ± 2.15 (t: 22.4; p: 0.16, el grupo de experimento con valor inicial de 33.63 ± 2.12 y final de 31.54 ± 1.71 (t: 11.55; p = 0.003. La intervención educativa participativa contribuye a mejorar el nivel de IMC en los diabéticos obesos 2.Exogenous obesity increases morbidity and mortality risk and has been associated with nutritional habits, which in turn can be affected by health education. Health education aims to promote patient participation in achieving behavior change and healthy lifestyles. The objective of this study is to show the advantages of participatory education in the modification of body mass index (BMI in obese type-2 diabetics. A quasi-experimental study was performed with random allocation of two patient groups. The educational intervention was organized through a reflection-action process. BMI was measured at baseline and then monthly for 9 months during the intervention. The groups were analyzed by age and sex. Statistical

  1. Modification and performance evaluation of a mono-valve engine

    Science.gov (United States)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  2. Mono- versus polydrug abuse patterns among publicly funded clients

    Directory of Open Access Journals (Sweden)

    Relyea George

    2007-11-01

    Full Text Available Abstract To examine patterns of mono- versus polydrug abuse, data were obtained from intake records of 69,891 admissions to publicly funded treatment programs in Tennessee between 1998 and 2004. While descriptive statistics were employed to report frequency and patterns of mono- and polydrug abuse by demographic variables and by study years, bivariate logistic regression was applied to assess the probability of being a mono- or polydrug abuser for a number of demographic variables. The researchers found that during the study period 51.3% of admissions reported monodrug abuse and 48.7% reported polydrug abuse. Alcohol, cocaine, and marijuana were the most commonly abused substances, both alone and in combination. Odds ratio favored polydrug abuse for all but one drug category–other drugs. Gender did not affect drug abuse patterns; however, admissions for African Americans and those living in urban areas exhibited higher probabilities of polydrug abuse. Age group also appeared to affect drug abuse patterns, with higher odds of monodrug abuse among minors and adults over 45 years old. The discernable prevalence of polydrug abuse suggests a need for developing effective prevention strategies and treatment plans specific to polydrug abuse.

  3. Comparação entre a prevalência de transtornos mentais em pacientes obesos e com sobrepeso = Comparison between the prevalence of mental disorders in obese and overweight patients

    Directory of Open Access Journals (Sweden)

    Verdolin, Louise Deluiz

    2012-01-01

    Conclusões: Transtornos ansiosos foram mais prevalentes em pacientes obesos quando comparados aos pacientes com sobrepeso, alguns transtornos psíquicos associaram-se a obesidade grave e transtornos depressivos foram mais prevalentes em pacientes com circunferência da cintura muito aumentada. Estes resultados reafirmam a importância de considerar a abordagem psiquiátrica no manejo clínico da obesidade

  4. Gamma spectra pictures using a digital plotter. Program MONO; Representacion de Espectros directos mediante un trazado digital. Prograa MONO

    Energy Technology Data Exchange (ETDEWEB)

    Los Arcos, J. M.

    1978-07-01

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs.

  5. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Directory of Open Access Journals (Sweden)

    Chunping Liu

    Full Text Available Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE, whereas it has a scattered and patchy distribution in South China (SC. In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM. Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278 among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  6. The relationship between mono-abundance and mono-age stellar populations in the Milky Way disk

    CERN Document Server

    Minchev, I; Chiappini, C; Martig, M; Anders, F; Matijevic, G; de Jong, R S

    2016-01-01

    Studying the Milky Way disk structure using stars in narrow bins of [Fe/H] and [alpha/Fe] has recently been proposed as a powerful method to understand the Galactic thick and thin disk formation. It has been assumed so far that these mono-abundance populations (MAPs) are also coeval, or mono-age, populations. Here we study this relationship for a Milky Way chemo-dynamical model and show that equivalence between MAPs and mono-age populations exists only for the high-[alpha/Fe] tail, where the chemical evolution curves of different Galactic radii are far apart. At lower [alpha/Fe]-values a MAP is composed of stars with a range in ages, even for small observational uncertainties and a small MAP bin size. Due to the disk inside-out formation, for these MAPs younger stars are typically located at larger radii, which results in negative radial age gradients that can be as large as 2 Gyr/kpc. Positive radial age gradients can result for MAPs at the lowest [alpha/Fe] and highest [Fe/H] end. Such variations with age p...

  7. Biopolítica e confissão: cenas do grupo terapêutico com pacientes obesos Biopolitics and confession: scenes of group therapy with obese patients

    Directory of Open Access Journals (Sweden)

    Shirley Dias Gonçalves

    2012-01-01

    Full Text Available Este trabalho é baseado numa pesquisa realizada em um hospital público, especializado em cirurgia bariátrica na cidade de Fortaleza- CE e teve como objetivo investigar os discursos que circulam no grupo terapêutico realizado com pacientes diagnosticados obesos e como esses pacientes são subjetivados por esses discursos. A metodologia utilizada foi a observação participante do referido grupo composto por pacientes de ambos os sexos que estavam na fase pré e pós-operatória. Foram analisados dois dispositivos presentes no controle da obesidade: a biopolítica e a confissão. A cirurgia bariátrica funciona como uma estratégia biopolítica que incide sobre o corpo de uma população obesa e a confissão atua como tecnologia de si. Assim, esse trabalho buscou problematizar como o corpo obeso é demarcado por práticas de saber-poder que o constituem. Também se tratou de analisar as resistências ao discurso médico-científico sobre saúde, beleza e boa forma dos corpos.This work focuses on a research conducted in a Brazilian community hospital specialized in bariatric surgery (in Fortaleza, state of Ceará with the aim of analyzing therapy group discussions with obese patients and how the patients are subjected by these discussions. The research used participant observation methodology. The group was composed of both male and female patients in the pre- and post-operative periods. Two obesity control devices were analyzed: biopolitics and confession. Bariatric surgery acts as a biopolitical strategy on the obese population body, and confession works as a technology of the self. Therefore, this work questioned how knowledge-power practices determine an obese body. Additionally, the research analyzed the resistance to medical-scientific discussions regarding body health, beauty and fitness.

  8. Influência do treinamento aeróbio e anaeróbio na massa de gordura corporal de adolescentes obesos Influencia del entrenamiento aeróbico y anaeróbico en la masa grasa corporal de adolescentes obesos Influence of the aerobic and anaerobic training on the body fat mass in obese adolescents

    OpenAIRE

    2004-01-01

    O objetivo deste estudo foi verificar as influências do exercício aeróbio e anaeróbio na composição corporal de adolescentes obesos do sexo masculino. A amostra foi constituída de 28 adolescentes com idades entre 15 e 19 anos, que apresentavam obesidade grave. Os voluntários foram distribuídos aleatoriamente em três grupos: grupo I: exercício anaeróbio; grupo II: exercício aeróbio; e grupo III: controle. O grupo I realizou treinamento intervalado em cicloergômetro que consistiu de 12 "tiros" ...

  9. Comparação das variáveis cardiorrespiratórias de adolescentes obesos e não obesos em esteira e bicicleta ergométrica Comparison of the cardiorespiratory variables of obese and non-obese adolescents on treadmill and ergometric bicycle

    Directory of Open Access Journals (Sweden)

    Gerusa Eisfeld Milano

    2009-08-01

    Full Text Available O objetivo deste estudo foi investigar o consumo máximo de oxigênio (VO2max em adolescentes obesos e não obesos em esteira e bicicleta ergométrica. O estudo foi transversal e descritivo com a amostra de 54 indivíduos obesos (23 meninos e 31 meninas e 33 não obesos (16 meninos e 17 meninas com idade entre 10 e 16 anos. Utilizou-se o critério dos Centers for Disease Control and Prevention (CDC, 2000 para a classificação do índice de massa corporal (IMC. Foram avaliados o peso, estatura, índice de massa corporal (IMC e IMC-escore Z. Para avaliação cardiorrespiratória foi realizado teste máximo em esteira e bicicleta ergométrica. Foram avaliados a frequência cardíaca máxima (FCmax, coeficiente respiratório (RER, consumo máximo de oxigênio (VO2max, tempo total de teste (TT e carga final (w na bicicleta ergométrica. Utilizou-se o teste de t de Student para a comparação dos ergômetros. Nas análises dos grupos, utilizou-se a ANOVA fatorial. Considerou-se significante p The aim of this study was to investigate the oxygen maximal uptake (VO2max in obese and non-obese adolescents on treadmill and ergometric bicycle. The study was transversal and descriptive with a sample of 54 obese individuals (23 boys and 31 girls and 33 non-obese individuals (16 boys and 17 girls, mean age of 10-16 years. The criterion by the Centers for Disease Control and Prevention (CDC, 2000 was used for classification of body mass index (BMI. Weight, height, body mass index (BMI and BMI-score Z were assessed. A maximal test on treadmill and ergometric bicycle was performed for cardiorespiratory assessment. Maximum heart rate (HRmax, respiratory coefficient (REC, maximal oxygen uptake (VO2max, test total time (TT and final load (w on ergometric bicycle were assessed. Student's t-test was used for ergometers comparison. Factorial ANOVA was used in the groups'analysis and p< 0.05 was considered significant. The results revealed that weight, BMI and BMI

  10. iOS Development using MonoTouch Cookbook

    CERN Document Server

    Tavlikos, Dimitris

    2011-01-01

    The book is written in a cookbook style, presenting examples in the style of recipes, allowing you to go directly to your topic of interest, or follow topics throughout a chapter to gain in-depth knowledge. This book is essential for C# and .NET developers with no previous experience in iOS development and Objective-C developers that want to make a transition to the benefits of MonoTouch and the C# language, for creating complete, compelling iPhone, iPod and iPad applications and deploying them to the App Store.

  11. Mono-W Dark Matter Signals at the LHC: Simplified Model Analysis

    CERN Document Server

    Bell, Nicole F; Leane, Rebecca K

    2015-01-01

    We study mono-W signals of dark matter (DM) production at the LHC, in the context of gauge invariant renormalizable models. We analyze two simplified models, one involving an s-channel Z' mediator and the other a t-channel colored scalar mediator, and consider examples in which the DM-quark couplings are either isospin conserving or isospin violating after electroweak symmetry breaking. While previous work on mono-W signals have focused on isospin violating EFTs, obtaining very strong limits, we find that isospin violating effects are small once such physics is embedded into a gauge invariant simplified model. We thus find that the 8 TeV mono-W results are much less constraining than those arising from mono-jet searches. Considering both the leptonic (mono-lepton) and hadronic (mono fat jet) decays of the W, we determine the 14 TeV LHC reach of the mono-W searches with 3000 fb$^{-1}$ of data. While a mono-W signal would provide an important complement to a mono-jet discovery channel, existing constraints on t...

  12. Mono-Energy Coronary Angiography with a Compact Synchrotron Source

    Science.gov (United States)

    Eggl, Elena; Mechlem, Korbinian; Braig, Eva; Kulpe, Stephanie; Dierolf, Martin; Günther, Benedikt; Achterhold, Klaus; Herzen, Julia; Gleich, Bernhard; Rummeny, Ernst; Noёl, Peter B.; Pfeiffer, Franz; Muenzel, Daniela

    2017-02-01

    X-ray coronary angiography is an invaluable tool for the diagnosis of coronary artery disease. However, the use of iodine-based contrast media can be contraindicated for patients who present with chronic renal insufficiency or with severe iodine allergy. These patients could benefit from a reduced contrast agent concentration, possibly achieved through application of a mono-energetic x-ray beam. While large-scale synchrotrons are impractical for daily clinical use, the technology of compact synchrotron sources strongly advanced during the last decade. Here we present a quantitative analysis of the benefits a compact synchrotron source can offer in coronary angiography. Simulated projection data from quasi-mono-energetic and conventional x-ray tube spectra is used for a CNR comparison. Results show that compact synchrotron spectra would allow for a significant reduction of contrast media. Experimentally, we demonstrate the feasibility of coronary angiography at the Munich Compact Light Source, the first commercial installation of a compact synchrotron source.

  13. Mono(ADP-ribosylation) in rat liver mitochondria.

    Science.gov (United States)

    Frei, B; Richter, C

    1988-01-26

    This paper investigates protein mono(ADP-ribosylation) in rat liver mitochondria. In isolated inner mitochondrial membranes, in the presence of both ADP-ribose and NAD+, a protein is mono-(ADP-ribosylated) with high specificity. The reaction apparently consists of enzymatic NAD+ glycohydrolysis and subsequent binding of free ADP-ribose to the acceptor protein. In terms of chemical stability, the resulting bond is unique among the ADP-ribose linkages thus far characterized. Formation of a Schiff base adduct between free ADP-ribose and the acceptor protein is excluded. In intact mitochondria at least three classes of proteins are ADP-ribosylated in vivo. One ADP-ribose-protein linkage is of the carboxylate ester type as indicated by its lability in neutral buffer. Another class of ADP-ribosylated proteins requires hydroxylamine for release of ADP-ribose. The third class is stable in hydroxylamine but labile to alkali, similar to the ADP-ribose-cysteine linkage in transducin formed by pertussis toxin.

  14. Leptonic mono-top from single stop production at LHC

    CERN Document Server

    Duan, Guang Hua; Wu, Lei; Yang, Jin Min; Zhang, Mengchao

    2016-01-01

    Top squark (stop) can be produced via QCD interaction but also the electroweak interaction at the LHC. In this paper, we investigate the observability of the associated production of stop and chargino, $pp \\to \\tilde{t}_1\\tilde{\\chi}^-_1$, in compressed electroweakino scenario at the 14 TeV LHC. Due to the small mass-splitting between the lightest neutralino ($\\tilde{\\chi}^0_1$) and chargino ($\\tilde{\\chi}^-_1$), such a single stop production can give a mono-top signature through the stop decay $\\tilde{t}_1 \\to t \\tilde{\\chi}^0_1$. Focusing on the leptonic mono-top channel, we propose a lab-frame observable $\\cos\\theta_{b\\ell}$ to reduce the SM backgrounds in virtue of a boosted top quark from the stop decay. We find that the single stop production can be probed at $2\\sigma$ level at the HL-LHC for $m_{\\tilde{t}_1}<760$ GeV and $m_{\\tilde{\\chi}^0_1}<150$ GeV.

  15. Prevalencia de hiperlipidemia e hiperglicemia en niños obesos: ¿riesgo aumentado de enfermedad cardiovascular? Hyperlipidemia and hyperglycemia prevalence in obese children: increased risk of cardiovascular disease?

    Directory of Open Access Journals (Sweden)

    M. Marcano

    2006-08-01

    Full Text Available Las enfermedades cardiovasculares representan la primera causa de muerte en Venezuela desde el año 1967. Existen evidencias que demuestran que la lesión temprana de la aterosclerosis coronaria se inicia en la infancia con marcada asociación a la obesidad y diabetes, por lo que su prevención debe iniciarse en esa época. Objetivo: Estudiar la presencia de hiperlipidemia e hiperglicemia en niños obesos como indicadores de riesgo. Metodología: Se seleccionaron 121 niños (edad 8,7±3,43 años, con índice de masa corporal mayor al P90 para su edad (Fundacredesa. Se determinó colesterol sérico total y fracciones (HDL-C y LDL-C, triglicéridos y glicemia en ayunas por métodos enzimáticos-colorimétricos.Se utilizaron puntos de corte para colesterol y triglicéridos según referencia nacional (Fundacredesa, para las LDL-C y HDL-C, los criterios del National Cholesterol Education Program y para glicemia según la American Diabetes Association. La muestra se agrupó por edad en: 2-5,11 años (19%: Grupo 1; 6-8,11 años (28,1%: Grupo 2 y mayores de 9 años (52,9%: Grupo 3. Análisis estadístico por genero y grupo etario. Resultados: El colesterol se ubicó en "riesgo" en los varones Grupo 1. Las HDL-C en riesgo en las niñas de Grupo 1 y Grupo 3 y en los varones Grupo 3. Los triglicéridos, se ubicaron en niveles de "riesgo" para las niñas Grupo 1 y Grupo 3 y varones Grupo 2 y en rango "elevado" en los varones Grupo 1 y Grupo 3. Las LDL-C, se ubicaron en todos los grupos en rango "aceptable" y no se encontró hiperglicemia en los niños evaluados. Conclusión: El perfil bajo de HDL y elevado de triglicéridos, sugiere un mayor riesgo de estos niños obesos a enfermedad cardiovascular, con mayor afectación en el género masculino. Una elevada proporción de ellos cumple con tres criterios definitorios de Síndrome metabólico por lo que se recomienda control dietario y modificaciones en el patrón de alimentación y de actividad f

  16. Evaluación inmunológica de proteínas recombinantes de fusión de dengue 1 y dengue 2 en monos

    OpenAIRE

    Bernardo Reyes, Lídice

    2010-01-01

    El desarrollo de subunidades recombinantes que contienen al dominio III de la proteína de la envoltura (E) de los virus del dengue (DEN) es una alternativa para el desarrollo de una vacuna segura contra esta entidad. En este trabajo caracterizamos la respuesta inmune inducida en monos por proteínas recombinantes de fusión de DEN 1 y DEN 2 que contienen al dominio III de la proteína E fusionado a la proteína P64k de Neisseria meningitidis. Se demostró que la proteína recombinante P64k-domin...

  17. Uric acid is associated with features of insulin resistance syndrome in obese children at prepubertal stage El ácido úrico se asocia con características de un síndrome de resistencia insulínica en los niños obesos en etapas prepuberales

    Directory of Open Access Journals (Sweden)

    M. Gil-Campos

    2009-10-01

    ingesta dietética y los parámetros asociados al síndrome de resistencia insulínica. El estudio se llevó a cabo en 34 niños obesos y 20 controles en edad prepuberal a los cuales se les estimó su ingesta dietética mediante el registro de un cuestionario de ingesta de alimentos de 72 h y un cuestionario de frecuencia de consumo de alimentos y se determinaron, además de los parámetros antropométricos, la glucosa, la insulina, la leptina, la adiponectina y el factor de necrosis tumoral alfa (TNF-α plasmáticos. Se realizó un análisis de regresión múltiple para identificar la asociación entre los niveles de ácido úrico y los parámetros antropométricos, la ingesta de nutrientes y las variables clásicas relacionadas con el síndrome de resistencia insulínica (hipertensión, glucosa, insulina, índice de resistencia insulínica HOMA, triglicéridos y HDL-colesterol plasmáticos, así como con leptina, adiponectina y TNF-α. La concentración plasmática de ácido úrico fue significativamente más elevada en los niños obesos que en los controles y, cuando se ajustó por sexo, edad e índice de masa corporal, los niveles de ácido úrico se asociaron con el pliegue tricipital y la resistencia inulínica, y negativamente con la adiponectina. En el análisis de regresión múltiple, el índice de masa corporal, el HDL-colesterol y la adiponectina fueron predictores independientes del ácido úrico plasmático. En conclusión, los niveles elevados de ácido úrico en niños obesos en edad prepuberal, comparado con los de los niños normales, representan una alteración metabólica temprana asociada con la resistencia insulínica.

  18. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: Update. Consensus SEMICYUC-SENPE: Obese patient Recomendaciones para el soporte nutricional y metabólico especializado del paciente crítico: Actualización. Consenso SEMICYUC-SENPE: Paciente obeso

    Directory of Open Access Journals (Sweden)

    A. Mesejo

    2011-11-01

    exercised when interpreting these data.El paciente obeso crítico, como respuesta al estrés metabólico, tiene igual riesgo de depleción nutricional que el paciente no obeso, pudiendo desarrollar una malnutrición energeticoproteica,con una acelerada degradación de masa muscular. El primer objetivo del soporte nutricional en estos pacientes debe ser minimizar la pérdida de masa magra y realizar una evaluación adecuada del gasto energético. Sin embargo, la aplicación de las fórmulas habituales para el cálculo de las necesidades calóricas puede sobrestimarlas si se utiliza el peso real, por lo que sería más correcto su aplicación con el peso ajustado o el peso ideal, aunque la alorimetría indirecta es el método de elección. La controversia se centra en si hay que aplicar un criterio estricto de soporte nutricional ajustado a los requerimientos o se aplica un cierto grado de hiponutrición permisiva. La evidencia actual sugiere que la nutrición hipocalórica puede mejorar los resultados, en parte debido a una menor tasa de complicaciones infecciosas y a un mejor control de la hiperglucemia, por lo que la nutrición hipocalórica e hiperproteica, tanto enteral como parenteral, debe ser la práctica estándar en el soporte nutricional del paciente obeso crítico si no hay contraindicaciones para ello. Las recomendaciones generalmente admitidas se centran en no exceder el 60-70% de los requerimientos o administrar 11-14 o 22-25 kcal/kg peso ideal/día, con 2-2,5 g/kg peso ideal/día de proteínas. En sentido amplio puede considerarse la nutrición hipocalórica-hiperproteica como específica del paciente obeso crítico, aunque las complicaciones ligadas a su comorbilidad hace que se planteen otras posibilidades terapéuticas, con nutrientes específicos para hiperglucemia, síndrome del distrés respiratorio agudo (SDRA y sepsis. Sin embargo, no existe ningún estudio prospectivo y aleatorio con este tipo de nutrientes en este subgrupo concreto de población y

  19. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Science.gov (United States)

    2010-07-01

    ... polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether. 721.1729 Section 721.1729 Protection... acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and......

  20. Mono- and combined antimicrobial agents efficiency in experimental wound infection

    Directory of Open Access Journals (Sweden)

    Наталія Ігорівна Філімонова

    2015-10-01

    Full Text Available Modern problems of antibiotic therapy are shown by wide range of side effects, both on organism and microbiological levels: the spread of allergies, toxic for organ systems reactions, dysbiosis development, and resistant pathogens formation and dissemination. Therefore the necessity of search for new effective drugs with significant antimicrobial activity applied for the wounds treatment arises. Development of combined remedies on the background of different origin antimicrobial agents’ derivatives is one of the fight directions against infectious diseases in the skin pathology. Recently among the existing antimicrobial agents one should focus on antiseptic drugs, due to degenerative and dysfunctional effect on microbial cell.Aim of research. The comparison of mono- and combined antimicrobial agents chemotherapeutic efficiency in the treatment of localized purulent infection under experimental conditions.Metods. The study of chemotherapeutic efficiency was carried out on the model of localized purulent Staphylococcus infection on albino mice weighting 14 – 16 g. S.aureus ATCC 25923 strains were used as infectious agents. The contamination was performed subcutaneously to the right side of mice’s skin after depilation. The animals were randomly divided into 4 groups: the 1st group – infected mice without treatment (control; the 2nd group – infected mice treated with a ciprofloxacin; the 3rd group – infected mice treated with a Ciprofloxacin and Decamethoxin combination; the 4th group – infected mice treated with a combined drug on the base of mutual prodrugs (Hexamethylenetetramine and Phenyl salicylate.Results. The efficiency of mono- and combined antimicrobial agents under experimental Staphylococcus wound infection conditions was studied. It was found that localized purulent staph center was formed more slowly in comparison with control and mono preparation use (2nd group of animals. The average index of skin lesions in comparison

  1. Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients Ensayo clínico aletorizado doble ciego controlado con placebo con una galleta enriquecida en ácido alfa linoleico y prebióticos en el patrón de riesgo cardiovascular de pacientes obesos

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2011-08-01

    Full Text Available Introduction: Inulin and FOS are prebiotics with potential benefit in cardiovascular risk factors. Alpha linolenic acid (ALA is the metabolic precursor of the long chain n-3 fatty acid eicosapentaenoic acid (20: 5n-3, this fatty acid has anti-inflammatory properties. The aim of our study was to evaluate the response of the cardiovascular risk profile in obese patients after inclusion in the diet of an ALA, FOS and inulin enriched-cookie. Material and methods: 36 patients were randomized in both branches: group I (inulin, FOS and ALA enriched cookie Gullon SL® and group II (control cookie. Previous and after 1 month of the treatment, a nutritional and biochemical study was realized. Results: 15 patients finished the procotol in each group. In group I, a significantly increase in soluble fiber (2.3 ± 0.8 g/day vs 7.7 ± 0.8 g/day: p Introducción: La inulina y los FOS son prebióticos con potenciales efectos beneficiosos a nivel cardiovascular. El acido alfa linolénico (ALA es el precursor del ácido eicosapentaenoico (20: 5n-3, presentando propiedades antinflamatorias. El objetivo de nuestro trabajo es evaluar la respuesta del perfil de riesgo cardiovascular en pacientes obesos tras la inclusión en la dieta de una galleta enriquecida en inulina, FOS y ALA. Material y métodos: Un total de 36 pacientes fueron randomizados a una de las siguientes ramas: galleta I (enriquecida con inulina, FOS y ALA y galleta II (galleta control (Gullón SL. Cada paciente recibió un total de 2 galletas al día (70 gramos de producto. Antes de iniciar el tratamiento y al mes, se realizó una valoración nutricional y analítica. Resultados: Finalizaron el protocolo un total de 15 pacientes en cada grupo. En el grupo I se produjo un aumento significativo en la ingesta de fibra soluble (2,3 ± 0,8 g/día vs 7,7 ± 0,8 g/día: p < 0,05 (inulina y FOS, así como ALA (0,6 ± 0,5 g/día vs 3,8 ± 0,5 g/día; p < 0,05. Se detectó en los pacientes varones que

  2. Avaliação da força muscular respiratória e amplitudes torácicas e abdominais após a RFR em indivíduos obesos

    Directory of Open Access Journals (Sweden)

    Dirceu Costa

    Full Text Available Este estudo teve como objetivo avaliar os elementos da mecânica respiratória, de indivíduos obesos no que se refere á força muscular respiratória, através das medidas de Pressão Respiratória Máxima (PImáx e PEmáx e, da mobilidade tóraco abdominal, através da Amplitude Tóraco-Abdominal nos níveis: axilar (AAx, xifoidiano (AXf e abdominal (AAb. Avaliaram-se 29 indivíduos obesos com média de idade de 43 ± 13 anos, divididos em dois grupos: Grupo Experimental (E e Grupo Controle (C, através das medidas da PImáx e da PEmáx e Amplitude Tóraco-abdominal. O Grupo E foi submetido a 18 sessões de Reeducação Funcional Respiratória (RFR que constituiu-se de orientação respiratória, exercícios de coordenação da respiração associados aos movimentos de tronco e membros, alongamento geral da musculatura e relaxamento muscular, 2 vezes por semana, durante 9 semanas. Constatou-se, através do Teste-t de Student (p<0.05, que não ocorreram diferenças significativas nos valores da PEmáx em ambos os grupos estudados mas, a PImax, a AXif e a AAbd aumentaram significativamente no E. Esses resultados permitem concluir que a RFR causou um aumento na força muscular inspiratória e das amplitudes tóraco-abdominais desses indivíduos obesos.

  3. Mechanically flexible optically transparent porous mono-crystalline silicon substrate

    KAUST Repository

    Rojas, Jhonathan Prieto

    2012-01-01

    For the first time, we present a simple process to fabricate a thin (≥5μm), mechanically flexible, optically transparent, porous mono-crystalline silicon substrate. Relying only on reactive ion etching steps, we are able to controllably peel off a thin layer of the original substrate. This scheme is cost favorable as it uses a low-cost silicon <100> wafer and furthermore it has the potential for recycling the remaining part of the wafer that otherwise would be lost and wasted during conventional back-grinding process. Due to its porosity, it shows see-through transparency and potential for flexible membrane applications, neural probing and such. Our process can offer flexible, transparent silicon from post high-thermal budget processed device wafer to retain the high performance electronics on flexible substrates. © 2012 IEEE.

  4. Mono-jet Signatures of Gluphilic Scalar Dark Matter

    CERN Document Server

    Godbole, Rohini M; Shivaji, Ambresh; Tait, Tim M P

    2016-01-01

    A gluphilic scalar dark matter (GSDM) model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum ("mono-jet") in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT) treatment, and find (as expected) that EFT does not accurately describe regions of parameter space where mass of the colored mediator particles are comparable to the experimental cuts on the missing energy. We determine bounds (for several choices of SU(3) representation of the mediator) from the $\\sqrt{s}=$ 8 TeV data, and show the expected reach of the $\\sqrt{s}=$ 13 TeV LHC and a future 100 TeV $pp$ collider to constrain or discover GSDM models.

  5. Enantioselective recognition of mono-demethylated methoxychlor metabolites by the estrogen receptor.

    Science.gov (United States)

    Miyashita, Masahiro; Shimada, Takahiro; Nakagami, Shizuka; Kurihara, Norio; Miyagawa, Hisashi; Akamatsu, Miki

    2004-02-01

    Metabolites of methoxychlor such as 2-(p-hydroxyphenyl)-2-(p-methoxyphenyl)-1,1,1-trichloroethane (mono-OH-MXC) and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (bis-OH-MXC), have estrogenic activity. Mono-OH-MXC is a chiral compound in which the carbon atom bridging two benzene rings is the chiral centre. In previous studies the estrogenic activity of racemic mono-OH-MXC has been measured, and the activity of each enantiomer of this compound has not yet been elucidated. In this study, we evaluated the estrogen receptor-binding activity of each enantiomer of mono-OH-MXC to clarify the enantioselective recognition by the estrogen receptor. (S)-mono-OH-MXC showed 3-fold higher binding activity than that of the (R) enantiomer. The activity of bis-OH-MXC was only 1.7-fold higher than that of (S)-mono-OH-MXC. This result suggests that the one hydroxy group and the orientation of the CCl3 group of mono- and bis-OH-MXCs are important for the interaction with the estrogen receptor. The result also points out the estrogenic activity of methoxychlor after metabolic activation in vivo, which predominantly produces the (S)-mono-OH-MXC, may be higher than estimated from the in vitro activity of racemic mixtures.

  6. Magnetic and gravity studies of Mono Lake, east-central, California

    Science.gov (United States)

    Athens, Noah D.; Ponce, David A.; Jayko, Angela S.; Miller, Matt; McEvoy, Bobby; Marcaida, Mae; Mangan, Margaret T.; Wilkinson, Stuart K.; McClain, James S.; Chuchel, Bruce A.; Denton, Kevin M.

    2014-01-01

    From August 26 to September 5, 2011, the U.S. Geological Survey (USGS) collected more than 600 line-kilometers of shipborne magnetic data on Mono Lake, 20 line-kilometers of ground magnetic data on Paoha Island, 50 gravity stations on Paoha and Negit Islands, and 28 rock samples on Paoha and Negit Islands, in east-central California. Magnetic and gravity investigations were undertaken in Mono Lake to study regional crustal structures and to aid in understanding the geologic framework, in particular regarding potential geothermal resources and volcanic hazards throughout Mono Basin. Furthermore, shipborne magnetic data illuminate local structures in the upper crust beneath Mono Lake where geologic exposure is absent. Magnetic and gravity methods, which sense contrasting physical properties of the subsurface, are ideal for studying Mono Lake. Exposed rock units surrounding Mono Lake consist mainly of Quaternary alluvium, lacustrine sediment, aeolian deposits, basalt, and Paleozoic granitic and metasedimentary rocks (Bailey, 1989). At Black Point, on the northwest shore of Mono Lake, there is a mafic cinder cone that was produced by a subaqueous eruption around 13.3 ka. Within Mono Lake there are several small dacite cinder cones and flows, forming Negit Island and part of Paoha Island, which also host deposits of Quaternary lacustrine sediments. The typical density and magnetic properties of young volcanic rocks contrast with those of the lacustrine sediment, enabling us to map their subsurface extent.

  7. Synthesis and Photocytotoxicity of Mono-functionalised Porphyrin with Valine Moiety

    Institute of Scientific and Technical Information of China (English)

    Wei Min SHI; Jian WU; Yi Feng WU; Kai Xian QIAN

    2004-01-01

    A mono-funtionalised tetraphenylporphyrin (TPP) bearing valine moiety at the phenyl ring was synthesized for photocytotoxicity examination in four steps, starting from regiospecific mono-nitration of TPP at the phenyl ring. The in vitro photocytotoxicitic effect against SPC-A1 adenocarcinona cell line was tested.

  8. Effectiveness of oxybutynin for treatment of hyperhidrosis in overweight and obese patients Eficácia da oxibutina no tratamento de hiperidrose em pacientes com sobrepeso e obesos

    Directory of Open Access Journals (Sweden)

    Nelson Wolosker

    2013-04-01

    Full Text Available OBJECTIVE: Until the present moment, the lack of efficient therapeutic options available for hyperhidrosis treatment in obese patients has left this population without prospect of clinical or quality of life (QOL improvements. Outcomes of oxybutynin treatment for overweight and obese patients with hyperhidrosis are unknown. This study aims to investigate the results related to clinical and QOL improvements in this specific population, submitted to a 12-week protocol treatment with oxybutynin. METHODS: 559 patients with palmar and axillary hyperhidrosis, routinely followed in this service, were divided into the groups, according to their body mass index (BMI ( 30 kg/m². Improvements in QOL and in the level of hyperhidrosis were analyzed after 12 weeks of protocol treatment with oxybutynin. These parameters were investigated using a scoring system based on a scientifically validated clinical questionnaire, applied before and after treatment. RESULTS: 67.8% of the overweight sample group and 63% of the obese patients presented "partial" or "great" improvement in the level of hyperhidrosis. Over 65% of patients demonstrated improvement in QOL ("much better" or "slightly better" for all three groups, with no statistical difference between them. The only adverse event associated with oxybutynin was dry mouth, observed in 63.0% of the patients. CONCLUSION: Overweight and obese patients with palmar or axillary hyperhidrosis present significant improvement in QOL after treatment with oxybutynin, and the results are comparable to those of normal weight individuals.OBJETIVO: A falta de alternativas terapêuticas para o tratamento de pacientes obesos com Hiperidrose hiperidrose deixa essa população sem perspectiva de melhorar suas condições clínicas e qualidade de vida. Resultados do tratamento com oxibutinina especificamenteempacientes com sobrepeso ou obesidade são desconhecidos até o presente momento. Este estudo tem como objetivo investigar os

  9. Metabolic syndrome in obese adolescents: what is enough? Síndrome metabólica em adolescentes obesos: o que é suficiente?

    Directory of Open Access Journals (Sweden)

    Leticia Esposito Sewaybricker

    2013-02-01

    Full Text Available OBJECTIVE: To study the agreement among three distinct criteria for metabolic syndrome (MS adapted to adolescents, and to identify associated factors for MS. METHODS: Cross-sectional study with 65 obese subjects aged 10 to 18 years, attended to at the Outpatient Clinic for Obese Children and Adolescents at the Clinical Hospital of the Universidade Estadual de Campinas (Unicamp. MS was defined using the criteria of the World Health Organization (WHO, the International Diabetes Federation (IDF, and the Adult Treatment Panel III (ATP III. Clinical, anthropometrical, and laboratorial data were associated to MS. RESULTS: From the 65 subjects, none had MS according to the WHO criteria, while 18 were diagnosed with MS (27.6% according to the IDF, and 19 (29.2% according to the ATP III. Agreement between IDF and ATP III was excellent (kappa 81%. In this study, puberty and triglycerides levels showed significant statistical difference when comparing subjects with and without MS, the first for ATP III (p = 0.03, and the second for IDF (p = 0.005 and ATP III (p = 0.001 criteria. CONCLUSION: The WHO criteria does not seem to be adequate for adolescents. IDF and ATP III criteria had an excellent agreement. Puberty and triglycerides were associated with MS.OBJETIVO: Avaliar a correlação de três critérios de síndrome metabólica (SM para adolescentes e identificar fatores associados. MÉTODOS: Estudo transversal com 65 pacientes obesos entre 10 e 18 anos do Ambulatório de Crianças e Adolescentes Obesos do HC-Unicamp. SM foi definida de acordo com a Organização Mundial da Saúde (OMS, International Diabetes Federation (IDF e Adult Treatment Panel III (ATP III. Buscaram-se fatores associados a SM em dados clínicos, antropométricos e laboratoriais. RESULTADOS: Dos 65 pacientes, nenhum foi diagnosticado como SM pela OMS, sendo 18 (27.6% pelo IDF e 19 (29.2% pelo ATP III. A correlação entre IDF e ATP III foi excelente (kappa 81%. Neste estudo, a

  10. Ensayo clínico aleatorizado con una galleta enriquecida en inulina en el patrón de riesgo cardiovascular de pacientes obesos Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients

    OpenAIRE

    D. A. De Luis; B. de la Fuente; O. Izaola; Conde, R.; Gutiérrez, S.; M. Morillo; C. Teba Torres

    2010-01-01

    Introducción: La inulina es un prebiótico con potenciales efectos beneficiosos a nivel cardiovascular. El objetivo de nuestro trabajo es evaluar la respuesta del perfil de riesgo cardiovascular en pacientes obesos tras la inclusión en la dieta de una galleta enriquecida en inulina. Material y métodos: Un total de 34 pacientes fueron randomizados a una de las siguientes ramas: galleta I (enriquecida con inulina, ver tabla I) y galleta II (galleta control, ver tabla I) (Gullón SL). Cada pacient...

  11. Estudio in vivo de la oxidación mitocondrial en pacientes obesos tratados mediante restricción calórica In vivo study of mitochondrial oxidation in obese patients treated by means of calorie restriction

    OpenAIRE

    M.ª D. Parra; B. E. Martínez de Morentín; Pérez, S.; M.ª C. Rodríguez; J. Alfredo Martínez

    2004-01-01

    La restricción calórica es la terapia nutricional más frecuente en el tratamiento de la obesidad, cuya eficacia depende de la respuesta oxidativa del organismo para evitar la modificación del peso corporal. En este contexto, el objetivo del presente trabajo fue examinarin vivo la oxidación mitocondrial de voluntarios obesos, antes y después de adelgazar, utilizando el test en aliento con 2-ceto[1-13C]isocaproato. El estudio se realizó en 32 voluntarios de ambos sexos: 16 controles (índice de ...

  12. Collide and Conquer: Constraints on Simplified Dark Matter Models using Mono-X Collider Searches

    CERN Document Server

    Brennan, A J; Gramling, J; Jacques, T D

    2016-01-01

    The use of simplified models as a tool for interpreting dark matter collider searches has become increasingly prevalent, and while early Run II results are beginning to appear, we look to see what further information can be extracted from the Run I dataset. We consider three `standard' simplified models that couple quarks to fermionic singlet dark matter: an $s$-channel vector mediator with vector or axial-vector couplings, and a $t$-channel scalar mediator. Upper limits on the couplings are calculated and compared across three alternate channels, namely mono-jet, mono-$Z$ (leptonic) and mono-$W/Z$ (hadronic). The strongest limits are observed in the mono-jet channel, however the computational simplicity and absence of significant $t$-channel model width effects in the mono-boson channels make these a straightforward and competitive alternative. We also include a comparison with relic density and direct detection constraints.

  13. Digital mono- and 3D stereo-photogrammetry for geological and geomorphological mapping

    Science.gov (United States)

    Scapozza, Cristian; Schenker, Filippo Luca; Castelletti, Claudio; Bozzini, Claudio; Ambrosi, Christian

    2016-04-01

    corresponding real world pixel on the DEM, and then extract georeferenced vector data and orthorectified raster data from terrestrial photographs (Bozzini et al., 2012; Scapozza et al., 2014). Through some case studies, we show (1) how 3D digital stereo-photogrammetry makes it possible the production of Quaternary geological and geomorphological maps, (2) how digital mono-photogrammetry is a powerful tool for supporting geological mapping in very steep zones and (3) how the combination of these two digital tools permits diachronical mapping of phenomena evolution (such as landslides or rockglaciers) during the entire twentieth century. Ambrosi C. and Scapozza C. 2015. Improvements in 3-D digital mapping for geomorphological and Quaternary geological cartography. Geographica Helvetica 70: 121-133. doi: 10.5194/gh-70-121-2015 Bozzini C., Conedera M. and Krebs P. 2012. A new monoplotting tool to extract georeferenced vector data and orthorectified raster data from oblique non-metric photographs. International Journal of Heritage in the Digital Era 1: 499-518. doi: 10.1260/2047-4970.1.3.499 Scapozza C., Lambiel C., Bozzini C., Mari S. and Conedera M. 2014. Assessing the rock glacier kinematics on three different timescales: a case study from the southern Swiss Alps. Earth Surface Processes and Landforms 39: 2056-2069. doi: 10.1002/esp.3599

  14. Estudo da correlação do IMC e comprimento do intestino delgado em pacientes obesos submetidos à cirurgia bariátrica Correlation study of BMI and small intestine length in obese patients subjected to bariatric surgery

    Directory of Open Access Journals (Sweden)

    Paulo Afonso Nunes Nassif

    2009-09-01

    Full Text Available RACIONAL: Segundo a hipótese do intestino longo, o comprimento do intestino delgado estaria relacionado à obesidade. Existem dados evolutivos, anatômicos e neuroendócrinos em favor desta afirmação. OBJETIVOS: Verificar a medida do comprimento do intestino delgado em pacientes obesos submetidos à cirurgia bariátrica e analisar a correlação entre o seu tamanho e o IMC. MÉTODO: A casuística foi composta de 30 pacientes do Serviço de Obesidade do Hospital Universitário Evangélico de Curitiba, submetidos à cirurgia bariátrica no período de março a junho de 2009, e previamente avaliados, verificando peso, altura e IMC. A técnica cirúrgica foi a de Fobi-Capella. A mensuração do intestino delgado foi realizada desde a flexura duodenojejunal à junção ileocecal, durante o trans-operatório, utilizando uma pinça de manipulação intestinal, a qual foi marcada com a medida de 10 cm. As alças intestinais foram medidas na margem anti-mesentérica, aplicando-se tensão mínima necessária para retificar as mesmas. Os dados foram correlacionados e tabulados estatisticamente, utilizando-se o método de correlação de Pearson. RESULTADOS: A média do comprimento intestinal para o sexo masculino foi de 582,5 cm e para o sexo feminino de 509,1. A partir do cálculo do coeficiente de correlação de Pearson, confirmou-se a ausência de correlação entre IMC e comprimento do intestino delgado. CONCLUSÃO: Obteve-se uma média de tamanho intestinal de 528,7 cm para toda a amostra. O comprimento do intestino delgado não possuiu correspondência com o IMC, não sendo um fator de significância neste estudo.BACKGROUND: According to the hypothesis of long bowel, the length of small intestine is related to obesity. There are evolutionary, anatomics, neuroendocrines evidences in favor of this assertion. AIM: To check the measure of the small intestine length in overweight patients submitted to bariatric surgery and to analyze the correlation

  15. Crenças e influências sobre dietas de emagrecimento entre obesos de baixa renda Beliefs and influences on weight loss diets among low-income obese individuals

    Directory of Open Access Journals (Sweden)

    Ana Paula Rodrigues Cavalcanti

    2007-12-01

    Full Text Available A obesidade tornou-se uma epidemia carente de controle imediato, principalmente entre pobres, mulheres e pessoas de baixa escolaridade. A OMS solicita e vários estudos corroboram que estudos esclarecedores sobre os comportamentos psicológicos e sociais interferentes na aderência terapêutica aos regimes devem ser encorajados. Este estudo usou a Teoria da Ação Racional - TAR, de M. Fishbein, em Psicologia Social, e comparou duas séries de entrevistas abertas (em 2001 e 2005 que eliciaram as crenças positivas (vantagens e negativas (desvantagens sobre fazer dieta entre obesos de baixa renda de João Pessoa, Paraíba, além dos referentes (pessoas de opinião influente destes pacientes quanto a segui-la. Os resultados de 2001 foram corroborados em 2005, revelando o medo das doenças relacionadas à obesidade e a vontade de sentir mais saúde e leveza de corpo. Mães, filhos e principalmente o cônjuge aparecem como apoiadores do regime. Ressaltou-se que não bastaria força de vontade, mas também reflexão e construção de habilidades de controle, apropriação e modificação das condições de vida. Preocupações estéticas não foram prioritárias. Estas informações podem fomentar melhores resultados na aderência terapêutica.Obesity has become an epidemic that requires immediate control, mainly among the poor, particularly women and the less educated. The WHO requests and several studies confirm that support is needed for research projects examining psychological and social behavior that hampers compliance with weight loss diets. This paper uses the Theory of Reasoned Action (TRA of M. Fishbein (1975 in social psychology, comparing two series of open interviews (conducted in 2001 and 2005 that disclosed positive (advantageous and negative (harmful beliefs about weight loss diets among low-income obese patients in João Pessoa, Paraíba State, as well as their guides (people of influential opinion on following their diets. The 2001

  16. First-principles investigation of the vacancy effect on the electronic properties in M2AlC(M = V and Nb

    Directory of Open Access Journals (Sweden)

    Liu Kun

    2014-10-01

    Full Text Available First principles calculations have been performed to study the mono-vacancy formation energies and electronic properties of M2AlC (M = V and Nb compound. The results show that the M mono-vacancy has a maximum formation energy. While the C mono-vacancy has a minimum formation energy, which means that the C mono-vacancy is the energetically most favorable in M2AlC. The d-electrons of M element contribute most to the DOS of M2AlC around the Fermi level, it implies that the conductivity of M2AlC comes from the transition metal M. The M-C bond is stronger than the M-Al bond, which is caused by the strong hybridization energy peak between M and C atom. In addition, the M-C bond is weaken in the presence of the M or C mono-vacancy. The cell volumes are reduced when the mono-vacancy is formed. These results help us to understand the origin of the defect-related properties and phase stability of V2AlC and Nb2AlC under extreme environment.

  17. Efecto del balón intragástrico como método alternativo en la pérdida de peso en pacientes obesos Effect of intragastric balloon as an alternative method for weight loosing in obese patients

    Directory of Open Access Journals (Sweden)

    G. Oviedo

    2009-02-01

    Full Text Available La obesidad se ha incrementado a nivel mundial, afectando a personas de todas las edades, constituyendo un grave problema de salud pública. Existen diversos tipos de tratamiento para la obesidad: dietético, farmacológico, entrenamiento físico, psicoterapia y quirúrgico. Se ha propuesto la colocación de un dispositivo de silicona similar a una esfera con una cantidad de 600ml denominado "balón intragástrico" indicado en pacientes con un índice de masa corporal superior a 30 kg/m². Objetivo: Evaluar el efecto del Balón Intragástrico como método alternativo en la pérdida de peso en pacientes obesos. Metodología: Estudio de tipo exploratorio, descriptivo, longitudinal y experimental. La muestra está constituida por 40 personas obesas. Se realizaron mediciones antropométricas de peso, talla, circunferencia abdominal y braquial, pliegues tricipital y subescapular; se calculó índice de masa corporal (IMC, área muscular y área grasa; al inicio, primero, tercer y sexto mes de la colocación del balón. Resultados: Muestra conformada por 31 mujeres (77,5% y 9 hombres (22,5%. El promedio de edad del sexo femenino fue 35,87 años, y del masculino 44,67 años. Al momento de finalizar el estudio se registró una pérdida total de peso promedio de 18,25 kg, IMC 5,95 kg/m², circunferencia de cintura 13,53 cm y circunferencia braquial 4,14 cm en ambos sexos; la disminución de las medidas antropométricas fue mayor en los hombres que en las mujeres. Conclusiones: El balón intragástrico resultó ser un método efectivo en la pérdida de peso en pacientes obesos; con mejor resultado en los hombres que en las mujeres.Obesity has increased worldwide affecting people of all ages and accounting for a severe public health problem. There exist several treatment options for obesity: dietary, pharmacological, physical exercising, psychotherapy, and surgical. Placement of the so-called intragastric ballonn, a silicone device similar to a 600-m

  18. 21 CFR 582.4505 - Mono- and diglycerides of edible fats or oils, or edible fat-forming acids.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Mono- and diglycerides of edible fats or oils, or... GENERALLY RECOGNIZED AS SAFE Emulsifying Agents § 582.4505 Mono- and diglycerides of edible fats or oils, or edible fat-forming acids. (a) Product. Mono- and diglycerides of edible fats or oils, or edible...

  19. Ferrous sulphate mono and heptahydrate reduction of hexavalent chromium in cement: effectiveness and storability

    Directory of Open Access Journals (Sweden)

    Valverde, J. L.

    2005-09-01

    Full Text Available In Community legislation, substances containing hexavalent chromium are classified as carcinogenic, mutagenic and sensitizing. In cement, hexavalent chromium intensifies sensitization and may set off severe allergic reactions in workers in routine contact with the product, whether in the factory or on construction sites. The allergic or contact dermatitis causes is a very painful disease that may lead to permanent worker disability. According to Directive 2003/53/EC of the European Parliament and the Council, Governments of all member countries will be required to prohibit the marketing and use, as of 17 January 2005, of any cement or cement preparation containing more than 2 ppm of chromium (VI. Hexavalent chromium can be reduced with ferrous sulphate to trivalent chromium, which is water-insoluble and therefore innocuous to the skin. The present paper reports the effects of adding ferrous sulphate mono- or heptahydrate to a commercial cement and the storage time of the mix on the concentration of hexavalent chromium. The salts studied were found to effectively reduce hexavalent chromium in cement for at least three months.

    Las sustancias que contienen cromo hexavalente están clasificadas en la legislación comunitaria como sustancias carcinogénicas, mutagénicas y sensibilizantes. El cromo hexavalente del cemento potencia la sensibilización y provoca graves reacciones alérgicas que sufren bastante a menudo los trabajadores que lo manipulan habitualmente, ya sea en fábrica o en el sector de la construcción. La dermatitis alérgica o de contacto que produce es muy dolorosa y puede dejar a los trabajadores en estado de discapacidad. La Directiva 2003/53/CE del Parlamento Europeo y del Consejo, exige a los Gobiernos de los países miembros, que a partir del 17 de enero de 2005, prohiban el uso y la comercialización de todos aquellos cementos y preparados que contengan cemento, cuyo contenido en cromo (VI soluble, una vez hidratados

  20. Separation of mono- and di-PEGylate of exenatide and resolution of positional isomers of mono-PEGylates by preparative ion exchange chromatography.

    Science.gov (United States)

    Nguyen, Ngoc-Thanh Thi; Lee, Jae Sun; Yun, Soi; Lee, E K

    2016-07-29

    Exenatide is a synthetic version of the 39-mer peptide of Exendin-4, which is an FDA-approved therapeutic against Type II diabetes mellitus. However, exenatide has a very short in-serum half-life and PEGylation have been performed to improve its in-serum stability. PEGylation often yields multivalent binding to non-specific residues, and the desired species should be carefully separated by chromatographies. In this study, we first devised an aqueous-phase, two-step PEGylation process. This consists of thiolation of Lys 12 and 27 residues followed by attachment of PEG-maleimide (10kD) to thiol groups. This process yields various species: mono-PEGylates with positional isomers, di-PEGylate, and other higher MW substances. A prep-grade cationic exchange chromatography (HiTrap SP) at pH 3.0 partially separated mono- and di-PEGylates based on the molar ratio of conjugated PEG and peptide and thus molecular weight of the conjugates. To further investigate the chromatographic separation of positional isomers of mono-PEGylates, we prepared two kinds of exenatide analogs by point mutation; K12C and K27C. Each analog was mono-PEGylated with very high yield (>95%). When a mixture of the two positional isomers of mono-PEGylates was applied to HiTrap SP chromatography, K12C-PEGylate and K27C-PEGylate eluted separately at 0.22M and 0.33M NaCl, respectively. When the proportions of acid and its conjugate base of the amino acid residues adjacent to the PEGylation site at pH 3.0 were analyzed, K27C-PEGylate shows stronger positive charge than K12C-PEGylate, and we propose the residence time difference between the two mono-PEGylates could be due to the charge difference. ELISA result shows that the immuno-binding activity of both analogs and their mono-PEGylates are well maintained. Furthermore, both mono-PEGylates of the analogs show higher than 50-fold improved anti-trypsin stability. We expect that mono-PEGylates of the exenatide analogs are alternatives to the conventional C40

  1. Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial Alteraciones vasculares en ratones obesos por dieta rica en grasa: papel de la vía L-arginina/NO endotelial Vascular alterations in high-fat diet-obese rats: role of Endothelial L-arginine/NO Pathway

    Directory of Open Access Journals (Sweden)

    Thiago Bruder Nascimento

    2011-07-01

    Full Text Available FUNDAMENTO: Mecanismos subjacentes a anormalidades vasculares na obesidade ainda não estão completamente esclarecidos. OBJETIVO: Foi avaliada a via do óxido nítrico/L-arginina na resposta vascular de ratos obesos por dieta rica em gordura, enfocando as células endoteliais e do músculo liso. MÉTODOS: Ratos com 30 dias de vida foram divididos em 2 grupos: controle (C e obeso (OB, ratos sob dieta rica em gordura por 30 semanas. Após 30 semanas, foram registrados o peso corporal, índice de adiposidade, pressão arterial e perfis metabólicos e endócrinos dos animais. Foram obtidas curvas para noradrelanina na ausência e presença de inibidor de óxido nítrico sintase (L-NAME, 3x10-4M em aorta torácica intacta e com desnudamento em ratos C e OB. RESULTADOS: As medidas de peso corporal, índice de adiposidade, leptina e insulina aumentaram nos ratos OB, enquanto a pressão arterial permaneceu inalterada. A obesidade também produziu tolerância à glicose e resistência à insulina. A reatividade à noradrenalina da aorta intacta foi similar em ratos C e OB. A presença de L-NAME produziu um aumento similar nas respostas máximas, mas um desvio maior à esquerda das respostas nas aortas intactas dos ratos C em relação aos ratos OB [EC50 (x10-7M: C = 1,84 (0,83-4,07, O = 2,49 (1,41-4,38; presença de L-NAME C = 0,02 (0,01-0,04*, O = 0,21 (0,11-0,40*†,*p FUNDAMENTO: Los mecanismos subyacentes a las anormalidades vasculares en la obesidad todavía no están completamente aclarados. OBJETIVO: Se evaluó la vía del óxido nítrico/L-arginina en la respuesta vascular de ratones obesos por dieta rica en grasa, concentrándonos en las células endoteliales y en el músculo liso. MÉTODOS: Ratones con 30 días de vida que fueron divididos en 2 grupos: control (C y obeso (OB, ratones bajo dieta rica en grasa durante 30 semanas. Después de 30 semanas, fueron registrados el peso corporal, el índice de adiposidad, la presión arterial y los

  2. Professional iPhone Programming with MonoTouch and .NET/C#

    CERN Document Server

    McClure, Wallace B; Dunn, Craig

    2010-01-01

    What .NET C# developers need to enter the hot field of iPhone apps. iPhone applications offer a hot opportunity for developers. Until the open source MonoTouch project, this field was limited to those familiar with Apple's programming languages. Now .NET and C# developers can join the party. This Wrox guide is the first book to cover MonoTouch, preparing developers to take advantage of this lucrative opportunity.: MonoTouch opens the field of iPhone app development to .NET and C# developers for the first time; the Wrox reputation among .NET developers assures them that this guide covers everyt

  3. A new approach to modelling and designing mono-block dental implants

    OpenAIRE

    R. Hunter; F. Alister; Möller, J.; J. Alister

    2007-01-01

    Purpose: of this paper is present a new approach to modelling and design the low cost mono-block dental implants based on the integration of the computer aided techniques. This approach provides the automation of the design process of the mono-block dental implants.Design/methodology/approach: The approach used to develop the modelling and design of the mono-block dental implants are based on the parametrization of the main geometric features of the implants. This approach allows to generate ...

  4. Develop mono-block tooth implants using automate design and FEM analysis

    OpenAIRE

    J.P. Alister; J. Moller,; F. Alister; R. Hunter

    2007-01-01

    Purpose: Purpose of this paper is present a new approach to modelling and design the low cost mono-block dental implants based on the integration of the computer aided techniques. This approach provides the automation of the design process of the mono-block dental implants.Design/methodology/approach: The approach used to develop the modelling and design of the mono-block dental implants are based on the parametrization of the main geometric features of the implants. This approach allows to ...

  5. Interaction of potassium mono and di phosphates with bovine serum albumin studied by fluorescence quenching method.

    Science.gov (United States)

    Bakkialakshmi, S; Shanthi, B; Chandrakala, D

    2011-03-01

    The interactions between potassium mono and di phosphates and bovine serum albumin (BSA) were studied using fluorescence spectroscopy (FS) and ultraviolet spectroscopy (UV). The experimental results showed that the potassium mono and di phosphates could insert into the BSA and quench the inner fluorescence of BSA by forming the potassium mono phosphate-BSA and pottassium di phosphate-BSA complexes. It was found that the static quenching was the main reason leading to the fluorescence quenching. It was conformed by XRD and SEM techniques.

  6. Performance of a plasma window for a high pressure differentially pumped deuterium gas target for mono-energetic fast neutron production - Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Beer, A. de; Hershcovitch, A.; Franklyn, C.B.; Straaten, S. van; Guzek, J. E-mail: jguzek@debeers.co.za

    2000-09-01

    The reactions D(d,n){sup 3}He and T(d,n){sup 4}He are frequently used for production of the mono-energetic or quasi mono-energetic neutron beams but successful applications are often limited by the intensity of the generated neutron beams. The development of a suitable neutron source for such applications as studies of resonance phenomena, fast neutron radiography, selective fast neutron activation, explosives and contraband detection and others, depends on the output ion current of the accelerator and the design of the target system. A practical solution for a high pressure gas target was previously developed and successfully implemented at De Beers Diamond Research Laboratory in Johannesburg (Guzek et al., 1999), but it is limited to applications using low (<20%) duty cycle accelerators. The concept of a plasma window for the separation of a high pressure gas target region and accelerator vacuum, that was originally developed by Hershcovitch (1995) for electron welding applications, may be suitable for operation with continuous wave accelerators at high particle current output. Preliminary test results, which have been performed with various gases (argon, helium and deuterium), indicate that implementation of the plasma window into a gas target system, for the production of intense mono-energetic fast neutron beams will be achievable.

  7. Antioxidant and cytotoxic activity of mono- and bissalicylic acid derivatives

    Directory of Open Access Journals (Sweden)

    Đurendić Evgenija A.

    2014-01-01

    Full Text Available A simple synthesis of mono- and bis-salicylic acid derivatives 1-10 by the transesterification of methyl salicylate (methyl 2-hydroxybenzoate with 3-oxapentane-1,5-diol, 3,6- dioxaoctane-1,8-diol, 3,6,9-trioxaundecane-1,11-diol, propane-1,2-diol or 1-aminopropan- 2-ol in alkaline conditions is reported. All compounds were tested in vitro on three malignant cell lines (MCF-7, MDA-MB-231, PC-3 and one non-tumor cell line (MRC- 5. Strong cytotoxicity against prostate PC-3 cancer cells expressed compounds 3, 4, 6, 9 and 10, all with the IC50 less than 10 μmol/L, which were 11-27 times higher than the cytotoxicity of antitumor drug doxorubicin. All tested compounds were not toxic against the non-tumor MRC-5 cell line. Antioxidant activity of the synthesized derivatives was also evaluated. Compounds 2, 5 and 8 were better OH radical scavengers than commercial antioxidants BHT and BHA. The synthesized compounds showed satisfactory scavenger activity, which was studied by QSAR modeling. A good correlation between the experimental variables IC50 DPPH and IC50 OH and MTI (molecular topological indices molecular descriptors and CAA (accessible Connolly solvent surface area for the new compounds 1, 3, and 5 was observed.

  8. THE RECOGNITION OF SPOKEN MONO-MORPHEMIC COMPOUNDS IN CHINESE

    Directory of Open Access Journals (Sweden)

    Yu-da Lai

    2012-12-01

    Full Text Available This paper explores the auditory lexical access of mono-morphemic compounds in Chinese as a way of understanding the role of orthography in the recognition of spoken words. In traditional Chinese linguistics, a compound is a word written with two or more characters whether or not they are morphemic. A monomorphemic compound may either be a binding word, written with characters that only appear in this one word, or a non-binding word, written with characters that are chosen for their pronunciation but that also appear in other words. Our goal was to determine if this purely orthographic difference affects auditory lexical access by conducting a series of four experiments with materials matched by whole-word frequency, syllable frequency, cross-syllable predictability, cohort size, and acoustic duration, but differing in binding. An auditory lexical decision task (LDT found an orthographic effect: binding words were recognized more quickly than non-binding words. However, this effect disappeared in an auditory repetition and in a visual LDT with the same materials, implying that the orthographic effect during auditory lexical access was localized to the decision component and involved the influence of cross-character predictability without the activation of orthographic representations. This claim was further confirmed by overall faster recognition of spoken binding words in a cross-modal LDT with different types of visual interference. The theoretical and practical consequences of these findings are discussed.

  9. Similar Sister Chromatid Arrangement in Mono- and Holocentric Plant Chromosomes.

    Science.gov (United States)

    Schubert, Veit; Zelkowski, Mateusz; Klemme, Sonja; Houben, Andreas

    2016-01-01

    Due to the X-shape formation at somatic metaphase, the arrangement of the sister chromatids is obvious in monocentric chromosomes. In contrast, the sister chromatids of holocentric chromosomes cannot be distinguished even at mitotic metaphase. To clarify their organization, we differentially labelled the sister chromatids of holocentric Luzula and monocentric rye chromosomes by incorporating the base analogue EdU during replication. Using super-resolution structured illumination microscopy (SIM) and 3D rendering, we found that holocentric sister chromatids attach to each other at their contact surfaces similar to those of monocentrics in prometaphase. We found that sister chromatid exchanges (SCEs) are distributed homogeneously along the whole holocentric chromosomes of Luzula, and that their occurrence is increased compared to monocentric rye chromosomes. The SCE frequency of supernumerary B chromosomes, present additionally to the essential A chromosome complement of rye, does not differ from that of A chromosomes. Based on these results, models of the sister chromatid arrangement in mono- and holocentric plant chromosomes are presented.

  10. Adding Mono- and Multivalent Ions to Lyotropic Chromonic Liquid Crystals

    Science.gov (United States)

    Tortora, Luana; Park, Heung-Shik; Antion, Kelly; Woolwerton, Chris; Finotello, Daniele; Lavrentovich, Oleg

    2006-03-01

    Lyotropic Chromonic Liquid Crystals (LCLCs) are a distinct class of liquid crystals formed in aqueous solutions by molecules with rigid polyaromatic cores and ionic groups at the periphery [1-4]. The phase diagrams of these materials should depend on entropic factors (as in the Onsager model) and electrostatic interactions. Using optical polarizing microscopy, we studied the effects of mono- and multivalent ions on the phase diagrams of Blue 27 [3] and Sunset Yellow [2]. The monovalent ions change the temperatures of phase transitions, as described in [4], while the effect of multivalent ions is more dramatic and, in addition to the changed temperatures of phase transitions by tens of degrees, it often involves condensation of LCLC aggregates into domains with birefringence much higher than that in a normal nematic phase. Work supported by OBR B-7844. [1]J. Lydon, Current Opin. Colloid & Interface Sci. 3, 458 (1998);8, 480-489 (2004); [2]V. R. Horowitz, L. A. Janowitz, A. L. Modic, P. J. Heiney, and P. J. Collings, 2005, Phys. Rew. E 72, 041710; [3]Yu. A. Nastishin, H. Liu, T. Schneider, T., V. Nazarenko, R. Vasyuta, S. V. Shiyanovskii, and O. D. Lavrentovich, 2005, Phys. Rev. E 72, 041711; [4]A.F. Kostko, B. H. Cipriano, O. A. Pinchuk, L. Ziserman, M. A. Anisimov, D. Danino, and S. R. Raghavan. J. Phys. Chem. B 109, 19126-19133 (2005)

  11. A Mono Master Shrug Matching Algorithm for Examination Surveillance

    Directory of Open Access Journals (Sweden)

    Sandhya Devi G

    2014-12-01

    Full Text Available This paper proposes an unusual slant for Shrug recognition from Gesticulation Penetrated Images (GPI based on template matching. Shrugs can be characterized with image templates which are used to compare and match shrugs. The proposed technique makes use of a single template to identify match in the candidates and hence entitled as mono master shrug matching. It does not necessitate erstwhile acquaintance of movements, motion estimation or tracking. The proposed technique brands a unique slant to isolate various shrugs from a given video. Additionally, this method is based on the reckoning of feature invariance to photometric and geometric variations from a given video for the rendering of the shrugs in a lexicon. This descriptor extraction method includes the standard deviation of the gesticulation penetrated images of a shrug. The comparison is based on individual and rational actions with exact definitions varying widely uses histogram based tracker which computes the deviation of the candidate shrugs from the template shrug. Far-reaching investigation is done on a very intricate and diversified dataset to establish the efficacy of retaining the anticipated method.

  12. Problemas Psicológicos e Psicodinâmicos de crianças e adolescentes obesos: relato de pesquisa

    Directory of Open Access Journals (Sweden)

    Tarsila de Magalhães Andrade

    Full Text Available objetivo: Descrever e discutir os principais problemas psicológicos e psicodinâmicos de crianças e adolescentes obesos, considerando as variáveis individuais e as condutas psicológicas indicadas de acordo com a necessidade/ gravidade dos problemas apresentados. Método: Estudo transversal, retrospectivo, baseado no banco de dados das avaliações psicológicas de 491 casos selecionados de obesidade exógena de 1991 a 2007. O banco de dados foi organizado a partir de estudo preliminar para a caracterização dos principais problemas, variáveis individuais e condutas, e os dados analisados por distribuição de frequência, apresentados sob a forma de tabelas. Resultados: Resultados indicativos de 32,4% de casos de pais superprotetores ou de mães simbioticamente ligadas ao filho, 24,4% de casos de rejeição materna e consequente carência de afeto, 7,9% com pais alcoólicos ou drogadictos, 12,2% com pais portadores de graves problemas de saúde mental, que sofriam violências e maus tratos, 14,3% que passavam por angústias circunstanciais, mas com bons recursos internos e 8,8% de casos graves, que apresentavam imaturidade emocional. A psicodinâmica familiar perturbada levava as crianças a angústias, voracidade, sedentarismo, dificuldades escolares, isolamento ou agressividade. Queixas de discriminação social e baixa autoestima foram encontradas em grande parte, assim como queixas de incontrolável ansiedade, que levavam aos exageros alimentares. Conclusão: Dos 491 casos avaliados, somente 14,3% eram casos sem comprometimento emocional, tratando-se de angústias circunstanciais, ligadas ao momento existencial. Os demais casos, ou seja, 85,7%, mostravam raízes profundamente intrincadas na psicodinâmica familiar e requeriam cuidados, orientações e psicoterapia dirigidos não só ao paciente como também à sua família.

  13. Valoración diagnóstica y psicopatológica del trastorno por atracón en obesos mórbidos intervenidos de bypass gástrico Diagnostic and psychopathologic evaluation of binge eating disorder in gastric bypass patients

    Directory of Open Access Journals (Sweden)

    E. García Díaz

    2012-04-01

    Full Text Available Introducción: La presencia de trastorno por atracón (TA podría influir en los resultados del bypass gástrico laparoscópico (BPGL en el tratamiento de la obesidad mórbida. En población anglosajona, el TA suele valorarse mediante los cuestionarios Eating Disorder Examination-Questionnaire (EDE-Q y Questionnaire on Eating and Weight Patterns-Revised (QEWP-R. Objetivos: Estudiar la validez y concordancia del EDEQ y QEWP-R para el diagnóstico y valoración psicopatológica del TA en población española con obesidad mórbida intervenida mediante BPGL. Métodos: En un estudio transversal se le ha solicitado a 27 obesos mórbidos recién intervenidos mediante BPGL que cumplimentaran el EDE-Q y QEWP-R traducidos al español. Según las respuestas se han identificado los pacientes con y sin TA, evaluando posibles diferencias entre estos grupos en los ítems con interés psicométrico y midiendo la concordancia entre ambos cuestionarios. Resultados: El QEWP-R permitió diagnosticar un 25,9% de TA y el EDE-Q un 18,5%. Los pacientes con TA tuvieron mayores puntuaciones en los ítems sobre la importancia del peso o figura en la autovaloración, la interferencia en la capacidad de concentración por pensar en la comida, silueta o peso y la frecuencia del sentimiento de culpa después de comer. Entre ambos cuestionarios la concordancia diagnóstica fue escasa, pero se encontró una asociación fuerte entre los ítems con interés psicométrico. Conclusiones: El TA es frecuente en obesos mórbidos intervenidos mediante BPGL y forma un subgrupo de pacientes con más alteraciones psicopatológicas. El QEWP-R y el EDE-Q en español son cuestionarios adecuados para su valoración.Introduction: The presence of binge eating disorder (BED can influence the outcomes of laparoscopic gastric bypass (BPGL in the treatment of morbid obesity. In English population, BED is assessed usually through the Eating Disorder Examination-Questionnaire (EDE-Q and Questionnaire

  14. Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients Efecto de dos dietas hipocalóricas en los niveles de transaminasas y resistencia a la insulina en pacientes obesos con hígado graso no alcohólico

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2010-10-01

    Full Text Available Objective: The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without NAFLD and the relation with insulin resistance. Research Methods: A population of 162 obese patients was randomly allocated to two groups: a diet I (low fat and b diet II (low carbohydrate, dieting along 3 months. Patients were classified as group I (n=112 when serum ALT activity was normal or group II (NAFLD, n=30 when serum ALT activity was ( > or = 43 UI/L. Results: In control group with diet I, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet I improved the same parameters and glucose, triglycerides, ALT, AST, gamaglutamine transferase levels, too. In control group with diet II, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet II improved the same parameters and glucose, triglycerides, ALT and gamaglutamine transferase levels, without statistical changes in AST. Conclusion: We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hipertransaminasemia and insulin resistance in NAFLD patients.Objetivo: El objetivo de nuestro trabajo fue evaluar los cambios en las transaminasas tras la perdida de peso en pacientes obesos con y sin esteatohepatitis no alcohólica (EHNA y su relación con la resistencia a la insulina. Material y métodos: Se aleatorizó una muestra de 162 pacientes obesos en dos grupos: a dieta I (baja en grasa y b dieta II (baja en hidratos de carbono, siguiendo al dieta durante 3 meses. Los pacientes se clasificaron como grupo I (n=112, con unos niveles de ALT normales y grupo II (EHNA, n=30 con unos niveles de ALT superiores a 43 UI/L. Resultados: En el grupo I con la dieta I disminuyó el

  15. Effects of physical exercise and nutritional guidance on metabolic syndrome in obese adolescents Efeito do exercício físico e da orientação nutricional na síndrome metabólica em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    N Leite

    2009-02-01

    Full Text Available OBJECTIVES: To analyze the effects of physical exercise and nutritional guidance on body composition, physical fitness, lipid profile and insulin resistance among obese adolescents with and without metabolic syndrome. METHODS: Sixty-four obese adolescents (26 boys, 10-16 years of age, were divided into two groups: with metabolic syndrome (n=29 and without metabolic syndrome (n=35. They were classified as having metabolic syndrome if they met three or more criteria for age and sex according to the Adult Treatment Panel III (ATP III. Blood pressure, waist circumference, maximum oxygen uptake (VO2peak, blood glucose, blood insulin, homeostatic model assessment (HOMA-IR, quantitative insulin sensitivity check index (QUICKI and lipid profile were assessed at baseline and after 12 weeks of intervention. Both groups participated in 12 weeks of physical education and two nutritional guidance sessions. Each physical education session consisted of 50 min indoor cycling, 50 min of walking/running and 20 min of stretching, three times a week. RESULTS: Fifty-five participants (with metabolic syndrome=25; without metabolic syndrome=30 completed the treatment. After 12 weeks, both groups showed reductions in body weight, BMI z-score, waist circumference, fat mass and triglycerides; and increases in height, HDL-C and VO2peak (pOBJETIVOS: Analisar os efeitos de exercícios físicos (EF e orientação nutricional (ON sobre a composição corporal, aptidão física, perfil lipídico e resistência insulínica em adolescentes obesos com e sem síndrome metabólica (SM. MÉTODOS: 64 obesos (26 meninos, com idade entre 10 a 16 anos, divididos em dois grupos: com SM (n=29 e sem SM (n=35. Utilizou-se como critério de classificação de SM a presença de três ou mais critérios para idade e sexo de acordo com Adult Treatment Panel III (ATP III. Mensuraram-se antes e após 12 semanas de intervenção: pressão arterial, circunferência abdominal, consumo máximo de

  16. Uso de dexmedetomidina em pacientes obesos mórbidos submetidos a gastroplastia: estabilidade cardiovascular e consumo de anestésicos venosos. Estudo retrospectivo Uso de dexmedetomidina en pacientes obesos mórbidos sometidos a gastroplastia: estabilidad cardiovascular y consumo de anestésicos venosos. Estudio retrospectivo Dexmedetomidine in morbid obese patients undergoing gastroplasty: cardiovascular stability and consumption of intravenous anesthetics. A retrospective study

    Directory of Open Access Journals (Sweden)

    Luiz Piccinini Filho

    2006-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A utilização de agentes anestésicos potentes e de curta duração é fundamental em pacientes submetidos à intervenção cirúrgica bariátrica. A dexmedetomidina, agonista alfa 2-adrenérgico, surgiu como uma opção adjuvante da técnica de anestesia venosa. O objetivo desta pesquisa foi avaliar a eficácia da dexmedetomidina associada à anestesia venosa, em pacientes obesos mórbidos, submetidos a gastroplastia. MÉTODO: Análise retrospectiva, de pacientes portadores de obesidade mórbida, submetidos à intervenção cirúrgica bariátrica aberta, sob anestesia com propofol e alfentanil acrescidos ou não de dexmedetomidina. Os pacientes foram alocados em dois grupos: Controle (propofol e alfentanil e Dexmedetomidina (propofol, alfentanil e dexmedetomidina. A manutenção da anestesia nos dois grupos constou de propofol = 0,075 a 0,1 mg.kg-1.min-1 e alfentanil = 0,75 a 1 µg.kg-1.min-1; no grupo Dexmedetomidina na dose inicial de 1 µg.kg-1 em 10 min e manutenção com 0,4 a 0,7 µg.kg-1.h-1. As variáveis estudadas foram idade, sexo, IMC, tempos cirúrgico e de despertar, freqüência cardíaca (FC, pressão arterial sistólica e diastólica (PAS, PAD, saturação periférica de hemoglobina (SpO2, consumo de propofol e alfentanil e efeitos colaterais. RESULTADOS: Houve redução significativa do consumo de propofol e alfentanil no grupo Dexmedetomidina. A FC apresentou variação significativa apenas no grupo Dexmedetomidina. A PAS e a PAD apresentaram redução estatística significativa nos dois grupos nos primeiros 20 min, estabilizando-se a seguir. Os pacientes dos dois grupos não apresentaram efeitos colaterais. CONCLUSÕES: Este estudo demonstrou a eficácia do uso da dexmedetomidina associada à anestesia venosa com propofol e alfentanil, promovendo redução do consumo dos anestésicos venosos, estabilidade cardiovascular e tempo de despertar similar à técnica sem adição de dexmedetomidina. N

  17. Assessment of Mono- and Split-Window Approaches for Time Series Processing of LST from AVHRR—A TIMELINE Round Robin

    Directory of Open Access Journals (Sweden)

    Corinne Myrtha Frey

    2017-01-01

    Full Text Available Processing of land surface temperature from long time series of AVHRR (Advanced Very High Resolution Radiometer requires stable algorithms, which are well characterized in terms of accuracy, precision and sensitivity. This assessment presents a comparison of four mono-window (Price 1983, Qin et al., 2001, Jiménez-Muñoz and Sobrino 2003, linear approach and six split-window algorithms (Price 1984, Becker and Li 1990, Ulivieri et al., 1994, Wan and Dozier 1996, Yu 2008, Jiménez-Muñoz and Sobrino 2008 to estimate LST from top of atmosphere brightness temperatures, emissivity and columnar water vapour. Where possible, new coefficients were estimated matching the spectral response curves of the different AVHRR sensors of the past and present. The consideration of unique spectral response curves is necessary to avoid artificial anomalies and wrong trends when processing time series data. Using simulated data on the base of a large atmospheric profile database covering many different states of the atmosphere, biomes and geographical regions, it was assessed (a to what accuracy and precision LST can be estimated using before mentioned algorithms and (b how sensitive the algorithms are to errors in their input variables. It was found, that the split-window algorithms performed almost equally well, differences were found mainly in their sensitivity to input bands, resulting in the Becker and Li 1990 and Price 1984 split-window algorithm to perform best. Amongst the mono-window algorithms, larger deviations occurred in terms of accuracy, precision and sensitivity. The Qin et al., 2001 algorithm was found to be the best performing mono-window algorithm. A short comparison of the application of the Becker and Li 1990 coefficients to AVHRR with the MODIS LST product confirmed the approach to be physically sound.

  18. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

    Science.gov (United States)

    Van Meter, Michael; Mao, Zhiyong; Gorbunova, Vera; Seluanov, Andrei

    2011-01-01

    The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life, sirtuins regulate a diverse array of biological processes, including DNA repair, gene silencing, apoptosis and metabolism. Studies in multiple model organisms have indicated that sirtuins may also function to extend lifespan and attenuate age-related pathologies. To date, most of these studies have focused on the deacetylase activity of sirtuins, and relatively little is known about the other biochemical activity of sirtuins, mono-ADP ribosylation. We recently reported that the mammalian sirtuin, SIRT6, mono-ADP ribosylates PARP1 to promote DNA repair in response to oxidative stress. In this research perspective we review the role of SIRT6 in DNA repair and discuss the emerging implications for sirtuin directed mono-ADP ribosylation in aging and age-related diseases. PMID:21946623

  19. Developing C# Apps for iPhone and iPad using MonoTouch

    CERN Document Server

    Costanich, Bryan

    2011-01-01

    Developing C# Applications for iPhone and iPad using MonoTouch shows you how to use your existing C# skills to write apps for the iPhone and iPad. Fortunately, there's MonoTouch, Novell's .NET library that allows C# developers to write C# code that executes in iOS. Furthermore, MonoTouch allows you to address all the unique functions of the iPhone, iPod Touch, and iPad. And the big plus: You needn't learn any Objective-C to master MonoTouch!. Former Microsoft engineer and published app-store developer Bryan Costanich shows you how to use the tools you already know to create native apps in iOS

  20. Mono-Cycle Photonics and Optical Scanning Tunneling Microscopy Route to Femtosecond Ångstrom Technology

    CERN Document Server

    Yamashita, Mikio; Morita, Ryuji

    2005-01-01

    "Mono-Cycle Photonics and Optical Scanning Tunneling Microscopy" deals with both the ultrashort laser-pulse technology in the few- to mono-cycle region and the laser-surface-controlled scanning-tunneling microscopy (STM) extending into the spatiotemporal extreme technology. The former covers the theory of nonlinear pulse propagation beyond the slowly-varing-envelope approximation, the generation and active chirp compensation of ultrabroadband optical pulses, the amplitude and phase characterization of few- to mono-cycle pulses, and the feedback field control for the mono-cycle-like pulse generation. In addition, the wavelength-multiplex shaping of ultrabroadband pulse is described. The latter covers the CW-laser-excitation STM, the femtosecond-time-resolved STM and atomic-level surface phenomena controlled by femtosecond pulses.

  1. Geothermal systems of the Mono Basin-Long Valley region, eastern California and western Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, C.T.; Flynn, T.; Chapman, R.H.; Trexler, D.T.; Chase, G.R.; Bacon, C.F.; Ghusn, G. Jr.

    1985-01-01

    The region that includes Mono Basin, Long Valley, the Bridgeport-Bodie Hills area, and Aurora, in eastern California and western Nevada was studied to determine the possible causes and interactions of the geothermal anomalies in the Mono Basin-Long Valley region as a whole. A special goal of the study was to locate possible shallow bodies of magma and to determine their influence on the hydrothermal systems in the region. (ACR)

  2. Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones

    Institute of Scientific and Technical Information of China (English)

    Xing Yong Wang; Jing Nan Cui; Wei Min Ren; Feng Li; Chun Liang Lu; Xu Hong Qian

    2007-01-01

    Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity, the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h.By control of the reaction time and in the presence of DMF as co-solvent, the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84% yields with 10-93% ee.

  3. Evidence that Mono-ADP-Ribosylation of CtBP1/BARS Regulates Lipid Storage

    OpenAIRE

    Bartz, René; Seemann, Joachim; Zehmer, John K.; Serrero, Ginette; Kent D. Chapman; Anderson, Richard G. W.; Liu, Pingsheng

    2007-01-01

    Mono-ADP-ribosylation is emerging as an important posttranslational modification that modulates a variety of cell signaling pathways. Here, we present evidence that mono-ADP-ribosylation of the transcriptional corepressor C terminal binding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lipid storage in droplets that are surrounded by a monolayer of phospholipid and associated proteins. CtBP1/BARS is an NAD-binding protein that becomes ribosylated ...

  4. Mono-X, dijet, and long-lived particle searches at the LHC

    CERN Document Server

    McDonald, Emily; The ATLAS collaboration

    2016-01-01

    This document presents a summary of the most recent Run II searches and results in the mono-X (photon, Z/W/H), mono-/di-jet, and long-lived particle channels for the ATLAS and CMS experiments. Limits on Simplified Models of dark matter and Effective Field Theories in each channel are also presented where relevant as a complement to the SUSY, BSM Higgs, and Invisible Higgs results which are to be covered in a separate presentation.

  5. OVERVIEW OF MONO-ENERGETIC GAMMA-RAY SOURCES & APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Hartemann, F V; Albert, F; Anderson, G G; Anderson, S G; Bayramian, A J; Betts, S M; Chu, T S; Cross, R R; Ebbers, C A; Fisher, S E; Gibson, D J; Ladran, A S; Marsh, R A; Messerly, M J; O' Neill, K L; Semenov, V A; Shverdin, M Y; Siders, C W; McNabb, D P; Barty, C P; Vlieks, A E; Jongewaard, E N; Tantawi, S G; Raubenheimer, T O

    2010-05-18

    Recent progress in accelerator physics and laser technology have enabled the development of a new class of tunable gamma-ray light sources based on Compton scattering between a high-brightness, relativistic electron beam and a high intensity laser pulse produced via chirped-pulse amplification (CPA). A precision, tunable Mono-Energetic Gamma-ray (MEGa-ray) source driven by a compact, high-gradient X-band linac is currently under development and construction at LLNL. High-brightness, relativistic electron bunches produced by an X-band linac designed in collaboration with SLAC NAL will interact with a Joule-class, 10 ps, diode-pumped CPA laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. This MEGa-ray source will be used to excite nuclear resonance fluorescence in various isotopes. Applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. The source design, key parameters, and current status are presented, along with important applications, including nuclear resonance fluorescence. In conclusion, we have optimized the design of a high brightness Compton scattering gamma-ray source, specifically designed for NRF applications. Two different parameters sets have been considered: one where the number of photons scattered in a single shot reaches approximately 7.5 x 10{sup 8}, with a focal spot size around 8 {micro}m; in the second set, the spectral brightness is optimized by using a 20 {micro}m spot size, with 0.2% relative bandwidth.

  6. Assessing Ecological Impact Assessment: Lessons from Mono Lake, California.

    Science.gov (United States)

    Wiens, John A; Patten, Duncan T; Botkin, Daniel B

    1993-11-01

    Because of its high salinity and alkalinity, Mono Lake, in eastern California (USA), is a relatively simple ecosystem. It has become the focus of an environmental controversy over the effects of 50 yr of diversions of water from tributary streams to supply water to Los Angeles. Diversions lowered the lake level, increased the salinity, changed the availability of aquatic habitats, and altered the configuration of the shoreline and of islands that support breeding colonies of gulls. We consider (1) how two independent panels of experts synthesized scientific information on the lake ecosystem to assess the environmental consequences of these changes, and (2) how the findings of these groups influenced policy decisions and how well subsequent changes in the lake matched expectations. Despite differences in composition and approach, the two panels reached generally similar conclusions. These conclusions have been a major component of legal activities and the development of management plans for the lake and basin ecosystem. Both panels concluded that, because of the simplicity of the lake ecosystem, ecological consequences of changes in lake level and salinity associated with continuing diversions were likely to be unusually clear-cut. At certain lake levels these changes would be expected to alter algal and invertebrate populations and the populations of aquatic birds that feed upon them or to disrupt breeding activities in gull colonies. Projections about when critical lake levels might be reached, however, have not been met. This is largely because stream flows into the lake have been altered from recent historic patterns by the cessation of water diversions due to governmental and legal actions (prompted in part by the panels' findings) and by a prolonged drought. These events illustrate the difficulty of projecting a timetable for environmental changes, even in simple and well-studied ecosystems.

  7. Effect of Subgrains on the Performance of Mono-Like Crystalline Silicon Solar Cells

    Directory of Open Access Journals (Sweden)

    Su Zhou

    2013-01-01

    Full Text Available The application of Czochralski (Cz monocrystalline silicon material in solar cells is limited by its high cost and serious light-induced degradation. The use of cast multicrystalline silicon is also hindered by its high dislocation densities and high surface reflectance after texturing. Mono-like crystalline silicon is a promising material because it has the advantages of both mono- and multicrystalline silicon. However, when mono-like wafers are made into cells, the efficiencies of a batch of wafers often fluctuate within a wide range of >1% (absolute. In this work, mono-like wafers are classified by a simple process and fabricated into laser doping selective emitter cells. The effect and mechanism of subgrains on the performance of mono-like crystalline silicon solar cells are studied. The results show that the efficiency of mono-like crystalline silicon solar cells significantly depends on material defects that appear as subgrains on an alkaline textured surface. These subgrains have an almost negligible effect on the optical performance, shunt resistance, and junction recombination but significantly affect the minority carrier diffusion length and quantum efficiency within a long wavelength range. Finally, an average efficiency of 18.2% is achieved on wafers with hardly any subgrain but with a small-grain band.

  8. Prevalência dos riscos cardiovasculares em escolares e adolescentes obesos acompanhados no ambulatório de endocrinologia pediátrica do Conjunto Hospitalar de Sorocaba (CHS

    Directory of Open Access Journals (Sweden)

    Karlla Karollynna de Fátima Gaiotto

    2015-10-01

    Full Text Available Crianças e adolescentes obesos têm alto risco de desenvolver doençascardiovasculares na idade adulta. Assim, a detecção de fatores de risco e educaçãodos pacientes na infância é de extrema importância para o prognóstico, já que nesseperíodo a mudança dos hábitos de vida demonstra grande redução na incidência egravidade de doenças cardíacas. Desta forma, o objetivo do projeto foi avaliarrepercussões metabólicas associadas à obesidade nos pacientes atendidos noambulatório de endocrinologia pediátrica do CHS e seu impacto nos riscoscardiovasculares. Para isto foi realizada a análise do perfil bioquímico,antropométrico e níveis pressóricos de escolares e adolescentes obesos com idadeentre 07 e 18 anos no período de agosto de 2014 a maio de 2015 e calculada aprevalência para cada variável analisada. Dos 49 pacientes, 57,1% nasceram compeso adequado, 46,9% praticam atividade física insuficiente, 42,9% apresentamobesidade na família, 59,1% apresentam parentes obesos com algumacomorbidade, 81,3% se encaixam no percentil acima de 99 para o IMC, 90,55%apresentam circunferência de cintura acima de 71 cm, 44,1% foram consideradoshipertensos, 20,4% apresentaram alterações no perfil glicêmico, 34,7% possuemcolesterol total aumentado, 59,2% estão com HDL inferior ao desejável, 40,9%estão com níveis alterados de LDL, 49% apresentaram valores de VLDL elevado e30,6% apresentaram triglicérides aumentados. A análise dos dados deste estudopermite inferir que o IMC, pressão arterial, circunferência abdominal, colesterol total,HDL colesterol e triglicérides são aqueles cujos valores são mais expressivos, demonstrando as consequências diretas da obesidade no aumento do risco deeventos cardiovasculares futuros.

  9. Comportamientos sesgados según el sexo en el mono aullador negro y dorado (Alouatta caraya

    Directory of Open Access Journals (Sweden)

    Kowalewski, Martín M.

    2005-01-01

    Full Text Available Entender el comportamiento de los primates no-humanos permite entre otras cosas conocer el comportamiento de nuestros ancestros. El liderazgo en los desplazamientos puede influir en diferentes aspectos de la vida en grupo tales como el forrajeo y la defensa del territorio. Los trabajos que estudian estos aspectos en primates, se concentran en la relación entre el sexo del individuo que lidera un desplazamiento y su asociación con diferentes contextos comportamentales. Publicaciones en diversas especies indican que las hembras lideran desplazamientos hacia los sitios de alimentación, lo que estaría relacionado a una prioridad alimenticia. Los machos, en cambio, tienden a liderar desplazamientos hacia encuentros con otros grupos en defensa del territorio y de las hembras. En este trabajo presentamos información preliminar sobre el liderazgo de los desplazamientos de dos grupos de A. caraya, en la Isla Brasilera (20º 20`S, 58º 40`O, Chaco, Argentina. Las tropas fueron estudiadas 5 días por mes desde de Mayo a Noviembre de 2004 desde el amanecer hasta el anochecer. Se registraron 319 desplazamientos, donde al menos el 50% del grupo completaba el viaje entre diferentes sitos. Cuando los contextos fueron considerados juntos, no hubo diferencias significativas en el sexo que lideraba (X2=0.2, df=1, p>0.05. Se observó que los desplazamientos dirigidos a sitios de alimentación fueron liderados por hembras y los dirigidos hacia peleas, por machos (G=17.2, df=2, p<0.05. La división según el sexo en los desplazamientos de los monos aulladores y otras especies de primates nos permite inferir que la selección ha actuado sobre los comportamientos sesgados por sexo en el Orden Primates.

  10. Relación del estrés oxidativo y la pérdida de peso obtenida en pacientes obesos mórbidos mediante cirugía bariátrica con la técnica del cruce duodenal

    Directory of Open Access Journals (Sweden)

    Leonardo De Tursi Ríspoli

    2013-08-01

    Full Text Available Introducción: El estrés oxidativo, presente de forma evidente en los obesos mórbidos, es un indicador del estado inflamatorio crónico que representa la obesidad y posible nexo de unión con sus comorbilidades, algunas de las cuales son un importante factor de riesgo para el desarrollo de enfermedades cardiovasculares, por lo que la atenuación de su intensidad se ha convertido en un objetivo terapéutico. Material y método: Hemos intervenido de forma consecutiva, mediante la técnica quirúrgica del cruce duodenal, a 28 pacientes afectos de obesidad mórbida, realizando un estudio del estrés oxidativo presente en ellos mediante la determinación de productos de oxidación molecular y de antioxidantes, en el preoperatorio y a lo largo de un año tras la cirugía. Se ha controlado la evolución ponderal y la evolución de las comorbilidades presentes. Resultados: Los pacientes de la serie presentaron una media de edad de 43 ± 1 años y un IMC medio de 50,3. El 82% presentó comorbilidad asociada. Tras la cirugía todos los pacientes perdieron peso de forma progresiva a lo largo del periodo estudiado, con mejoría paralela de las comorbilidades y disminución progresiva de los valores del EO y mejoría de los sistemas antioxidantes, siendo los valores de EO al finalizar el estudio similares a los de la población normal. Conclusión: La pérdida de peso obtenida consigue una mejora de las comorbilidades y de los valores de estrés oxidativo de modo que al final del estudio los resultados obtenidos son similares a los de la población normal. Palabras clave: estrés oxidativo, obesidad, obesidad mórbida, cruce duodenal, pérdida de peso.

  11. Uso de preditores clínicos simples no diagnóstico pré-operatório de dificuldade de intubação endotraqueal em pacientes portadores de obesidade Uso de predictores clínicos sencillos en el diagnóstico preoperatorio de dificultad de intubación endotraqueal en pacientes obesos Use of simple clinical predictors on preoperative diagnosis of difficult endotracheal intubation in obese patients

    Directory of Open Access Journals (Sweden)

    Edno Magalhães

    2013-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar da semelhante incidência de dificuldade à laringoscopia em obesos e não obesos há mais relatos de dificuldade de intubação endotraqueal em portadores de obesidade. Alternativas de diagnóstico e previsão de dificuldade de intubação no pré-operatório podem ajudar diminuir complicações anestésicas em indivíduos obesos. O objetivo do estudo foi identificar preditores para diagnóstico de via aérea difícil em pacientes obesos, pela correlação com métodos clínicos de avaliação pré-anestésica e polissonografia. Comparou-se também a incidência de dificuldade à ventilação sob máscara facial e à laringoscopia entre obesos e não obesos, verificando os preditores mais prevalentes. MÉTODOS: Estudo observacional, prospectivo, comparativo, com 88 pacientes adultos, submetidos à anestesia geral. No período pré-operatório, avaliou-se questionário sobre preditores clínicos de síndrome da apneia obstrutiva do sono (SAOS e parâmetros anatômicos. Durante a anestesia, pesquisou-se dificuldade à ventilação sob máscara facial e laringoscopia. Para análise, estatística descritiva e teste de correlação. RESULTADOS: Os pacientes foram alocados em dois grupos, 43 obesos e 45 não obesos. Estado físico, prevalência de roncos, hipertensão e diabetes mellitus, circunferência cervical e índice de Mallampati foram maiores nos obesos. Pacientes obesos apresentaram maior incidência de dificuldade de ventilação sob máscara e laringoscopia. Nenhuma variável clínica ou anatômica apresentou correlação com dificuldade de ventilação sob máscara nos grupos. Nos obesos, o diagnóstico de SAOS mostrou forte correlação com dificuldade à laringoscopia. CONCLUSÕES: Os diagnósticos clínico e polissonográfico de SAOS se mostraram úteis no diagnóstico pré-operatório de dificuldade à laringoscopia. Pacientes obesos estão mais propensos à dificuldade de ventilação sob máscara e

  12. White tea (Camellia sinensis extract reduces oxidative stress and triacylglycerols in obese mice Extrato de chá branco reduz extresse oxidativo e triacilglicerois em camundongos obesos

    Directory of Open Access Journals (Sweden)

    Lílian Gonçalves Teixeira

    2012-12-01

    com 0,5% de extrato de chá branco durante 8 semanas. Foram estudadoso tecido adiposo bem como o perfil lipídico e o estresse oxidativo. A suplementação com chá branco não foi capaz de reduzir a ingestão alimentar, peso corporal ou adiposidade visceral. De forma similar, não foram encontradas diferenças no perfil de lipoproteínas ricas em colesterol. Uma redução de triacilgliceróis sanguíneos, associada ao aumento de lipídios cecais, foi observada no grupo suplementado com chá branco. A suplementação também reduziu o estresse oxidativo no fígado e tecido adiposo. Em conclusão, suplementação com extrato de chá branco (0,5% não interfere no peso corporal ou adiposidade em camundongos obesos. Seus benefícios são restritos redução do estresse oxidativo associada obesidade e melhora da hipertrigliceridemia.

  13. Avaliação ecocardiográfica em obesos graves assintomáticos Echocardiography evaluation for asymptomatic patients with severe obesity

    Directory of Open Access Journals (Sweden)

    Isaura Elaine Gonçalves Moreira Rocha

    2007-01-01

    Full Text Available OBJETIVO: Estudar a função sistólica e diastólica por meio da ecocardiografia Doppler em pacientes assintomáticos com obesidade grave. MÉTODOS: Foram avaliados, por meio de ecocardiograma transtorácico, 30 pacientes candidatos a cirurgia bariátrica, com IMC médio de 49,2±8,8 kg/m², sem história de cardiopatia prévia. RESULTADOS: Observou-se aumento de câmaras esquerdas em 42,9% da amostra, disfunção diastólica em 54,6%, hipertrofia ventricular esquerda em 82,1%, com padrão geométrico do tipo hipertrofia excêntrica em metade dos casos. A indexação da massa ventricular esquerda com a altura diagnosticou significativamente mais hipertrofia do que a indexação com a superfície corpórea (p = 0,0053, sendo esse índice mais apropriado para determinação de hipertrofia ventricular em obesos. Correlações entre hipertrofia ventricular esquerda com tempo de obesidade e níveis pressóricos foram positivas, bem como correlações entre o índice de massa corpórea e indicadores de disfunção diastólica. CONCLUSÃO: Este estudo mostrou que o ecocardiograma, realizado em portadores de obesidade grave assintomáticos, revelou alterações cardíacas estruturais comuns na miocardiopatia da obesidade, que podem associar-se ao desenvolvimento de insuficiência cardíaca, arritmias e morte súbita, possibilitando a identificação de pacientes sob maior risco cardiovascular.OBJECTIVE: To study the systolic and diastolic function of asymptomatic patients with severe obesity using a Doppler echocardiography. METHODS: Thirty candidates for bariatric surgery, with an average BMI of 49.2 ± 8.8 Kg/m² and no previous history of heart disease were evaluated through transthoracic echocardiography. RESULTS: Enlarged left chambers were observed in 42.9% of the sample, diastolic dysfunction in 54.6% and left ventricular hypertrophy in 82.1%, of which 50% of the cases presented the geometric pattern of eccentric hypertrophy. Indexation of left

  14. Aspectos nutricionais em obesos antes e após a cirurgia bariátrica Nutrition aspects in obese before and after bariatric surgery

    Directory of Open Access Journals (Sweden)

    Isabella Valois Pedrosa

    2009-08-01

    Full Text Available OBJETIVO: Determinar perfil clínico-nutricional de pacientes obesos submetidos à cirurgia bariátrica, no HC/UFPE. MÉTODOS: Foram avaliados retrospectivamente, 205 pacientes, no período 2002/2006. A análise considerou história clínica para diabetes tipo 2 (DM 2, hipertensão arterial (HA e síndrome metabólica (SM. O estado nutricional pré-operatório foi avaliado pelo IMC e bioquímica (hemoglobina, hematócrito, albumina, proteínas totais, triglicérides (TG, colesterol associado à lipoproteína de alta (HDLc e baixa (LDLc densidade e glicemia de jejum (GJ. Nos períodos pós-operatórios (6, 12, 18, 24 meses a avaliação nutricional foi feita pelas medidas de peso, perda ponderal, percentual de perda de peso (%PP, IMC e bioquímica incluindo ferro, ferritina e transferrina. RESULTADOS: 71,2% eram do sexo feminino, idade de 38,4 ± 9,96 anos, 129,66±27,40 Kg e IMC 48,6 ± 8,9 Kg/m², no pré-operatório. Receberam o diagnóstico de SM 26,8%, HA 52,7% e DM 2 11,7%. A bioquímica revelou TG, LDLc, GJ elevados, estando normais os demais parâmetros. Evolução antropométrica demonstrou perda ponderal progressiva, atingindo aos 24 meses IMC 31,7±5,82 Kg/m² (pOBJECTIVE: To determine the physical-nutritional profile of obese patients submitted to bariatric surgery at the HC/UFPE. MEHTODS: Two-hundred-and-five patients were evaluated retrospectively during the period of 2002 through 2006. Analysis considered clinical history for diabetes type 2 (DM 2, high blood pressure (HBP and metabolic syndrome (MS. The preoperative nutritional status was evaluated by MBI and the biochemistry (hemoglobin, hematocrit, albumin, total proteins, triglycerides (TG, cholesterol associated with the lipoprotein of high (HDLc and low (LDLc density and fasting glycemia (FG. During the postoperative periods (6, 12, 18, 24 months, we evaluated the nutritional status through measures of weight, weight loss, weight loss percentage (%WL, MBI and biochemistry

  15. Influencia de un programa de actividad física en niños y adolescentes obesos con apnea del sueño: protocolo de estudio

    Directory of Open Access Journals (Sweden)

    M. J. Aguilar Cordero

    2013-06-01

    Full Text Available Estudios recientes muestran un incremento alarmante en la tasa de sobrepeso/obesidad entre la población infanto-juvenil. La obesidad en la infancia se asocia con un importante número de complicaciones, como síndrome de apnea del sueño insulinorresistencia y diabetes tipo 2, hipertensión, enfermedad cardiovascular, algunos tipos de cáncer. Se estima que la prevalencia de apnea en niños es de un 2-3% en la población general, mientras que, en adolescentes obesos, varía entre el 13% y el 66%, según distintos estudios. Se asocia con la afectación de la función neurocognitiva, comportamiento, sistema cardiovascular, alteraciones metabólicas y del crecimiento. La apnea del sueño es un grave problema de salud pública que aumenta cuando los niños y adolescentes padecen sobrepeso y obesidad. Se postula el ejercicio de resistencia aeróbica como un tratamiento efectivo para la obesidad y la apnea de forma conjunta. El objetivo de este estudio es conocer si la actividad física en niños con sobrepeso/obesidad disminuye la apnea del sueño. Se realizará un estudio observacional, descriptivo, prospectivo, longitudinal con niños que padecen apnea del sueño y obesidad. El universo estará constituido por 60 niños y adolescentes con edades comprendidas entre 10 y 18 años que acudan a la consulta de endocrinología por tener obesidad en el Hospital Clínico San Cecilio de Granada durante el período de septiembre 2012-septiembre 2013. La muestra estará formada por niños y adolescentes que cumplan estas características y que sus padres/tutores hayan autorizado a través del consentimiento informado. La apnea del sueño se medirá en los niños mediante una polisomnografía y un cuestionario de calidad del sueño. También se hará una valoración nutricional a través de un cuestionario de frecuencia de consumo alimentario y una valoración antropométrica. De entre los resultados esperados están el bajar el sobrepeso y obesidad en los ni

  16. Estrategia probesci: un abordaje terapéutico de menor coste para el paciente obeso Probesci strategy: a cheaper therapeutic approach for obese patients

    Directory of Open Access Journals (Sweden)

    C. Vázquez

    2006-12-01

    Full Text Available Desde la experiencia clínica todas las evidencias hacen suponer que la obesidad, epidemia que amenaza la Salud Pública de los países más ricos de la Tierra, se presenta como un síndrome que abarca distintas enfermedades, todas ellas con un rasgo común, el exceso de grasa corporal, pero con respuestas clínicas claramente diferenciadas ante la misma estrategia terapéutica. Si las respuestas son tan heterogéneas es que la etiopatogenia también lo es, por lo que un estudio fenotípico exhaustivo ayudaría a establecer grupos clínicos que presumiblemente tendrían una respuesta más homogénea ante el mismo tratamiento. En este caso el abordaje y manejo terapéutico de los distintos grupos clínicos permitiría diversificar el tratamiento y posiblemente, mejorar su efectividad. El gran inconveniente para llevar a la práctica un estudio fenotípico exhaustivo es el elevado coste, por el consumo de tiempos recursos humanos que exige, lo que es con frecuencia inviable. En este estudio se describe la "estrategia PROBESCI" como un sistema organizativo de estudio y recogida de datos que sistematiza, estandariza y caracteriza la información constituyendo la base para la consiguiente clasificación y establecimiento de perfiles fenotípicos dentro de la obesidad. Es una nueva modalidad de consulta inicial en grupo, de valoración del paciente obeso, que ha demostrado su viabilidad. Se estudian los costes de esta nueva modalidad, comparándolos con los de la consulta clásica y se demuestra que supone un gran ahorro, ya que disminuye un 58% los costes de la consulta inicial y un 21% los costes totales del tratamiento.Obesity has become epidemic in Western countries. From clinical practice, obestity may be considered as a disease characterized by an excess of body fat mass, but patients usually demonstrate different responses to the same therapeutic strategy. It could be possible that the latter may be a consecuence of different pathophysiological

  17. CORROSION RESISTANCE OF Fe–Al/Al2O3 DUPLEX COATING ON PIPELINE STEEL X80 IN SIMULATED OIL AND GAS WELL ENVIRONMENT

    OpenAIRE

    MIN HUANG; YU WANG; PING-GU WANG; QIN-YI SHI; MENG-XIAN ZHANG

    2015-01-01

    Corrosion resistant Fe–Al/Al2O3 duplex coating for pipeline steel X80 was prepared by a combined treatment of low-temperature aluminizing and micro-arc oxidation (MAO). Phase composition and microstructure of mono-layer Fe–Al coating and Fe–Al/Al2O3 duplex coating were studied by X-ray diffraction (XRD), scanning electron microscope (SEM) with energy dispersive spectrometer (EDS). Corrosion resistance of the coated pipeline steel X80 in a simulated oil and gas well condition was also investig...

  18. El mono gramático y el sabio alquimista. Algunas reflexiones en torno a la poética de Octavio Paz en El Mono Gramático

    Directory of Open Access Journals (Sweden)

    Óscar Pujol

    2014-04-01

    Full Text Available El presente artículo es una comparación entre la poética de Octavio Paz en El Mono Gramático y un autor indio del siglo XI Abhinavagupta, a quien llamamos el Sabio Alquimista en referencia a la teoría india de la emoción estética: el rasa. Una idea subyacente en ambos autores es que el lenguaje ordinario enmascara la realidad, mientras que el lenguaje poético se resuelve en una abolición de la escritura que nos enfrenta a una realidad indecible. Se comparan un total de seis características distintas y se llega a la conclusión que la mayor discrepancia entre ambos autores es la naturaleza de esa realidad innombrable que revela la poesía. Para el autor indio se trata de una realidad inefable y gozosa: la conciencia pura. Para Paz es una realidad insoportable y enloquecedora, aunque al mismo tiempo fascinante. La diferencia es cultural, pues la tradición india adora a esa realidad innombrable mientras que la modernidad occidental desconfía de un absoluto inmensurable e impositivo. En este sentido Paz ejemplifica el dilema del hombre moderno: angustia ante esa realidad anterior al lenguaje, pero también una fascinación que busca en el arte y la poesía su modo último de expresión.

  19. Tratamento multidisciplinar reduz o tecido adiposo visceral, leptina, grelina e a prevalência de esteatose hepática não alcoólica (NAFLD em adolescentes obesos Tratamiento multidisciplinar reduce el tejido adiposo visceral, leptina, grelina y la prevalencia de esteatosis hepática no alcohólica (NAFLD en adolescentes obesos Multidisciplinary treatment reduces visceral adiposity tissue, leptin, ghrelin and the prevalence of non-alcoholic fat liver disease (NAFLD in obese adolescents

    Directory of Open Access Journals (Sweden)

    Ana R. Dâmaso

    2006-10-01

    Full Text Available O objetivo do presente estudo foi avaliar as alterações promovidas, por intervenção multidisciplinar, nas concentrações plasmáticas de grelina e leptina, adiposidade visceral e prevalência de esteatose hepática não alcoólica (NAFLD, em adolescentes obesos. Foram avaliados 28 adolescentes obesos, 16 meninas (IMC 34,58 ± 3,86kg/m² e 12 meninos (IMC 37,08 ± 3,17kg/m², com idade entre 15 e 19 anos, quanto à concentração de leptina, grelina, insulina, assim como a adiposidade visceral e o diagnóstico de NAFLD pelo método de ultra-sonografia. Os resultados demonstraram redução significante na concentração circulante de grelina e leptina e na adiposidade visceral (p El objetivo del presente trabajo ha sido evaluar las alteraciones promovidas por la intervención multidisciplinar, en las concentra- ciones plasmáticas de grelina y leptina, adiposidad visceral y prevalencia de esteatosis hepática no alcohólica - NAFLD, en adolescentes obesos. 28 adolescentes obesos, 16 chicas (IMC 34,58 ± 3,86 kg/m² y 12 chicos (IMC 37,08 ± 3,17 kg/m², con edades entre 15 y 19 años, fueron evaluados respecto a la concentración de leptina, grelina, insulina, así como a la adiposidad visceral y el diagnóstico de NAFLD por el método de ultrasonografía. Los resultados demostraron una reducción significante en la concentra- ción circulante de grelina y leptina y en la adiposidad visceral (p The aim of this study was to assess the changes promoted by a multidisciplinary therapy in ghrelin and leptin concentrations, visceral adiposity and non-alcoholic fat liver disease-NAFLD, in obese adolescents. A total of 28 obese adolescents, 16 girls (BMI 34.58 ± 3,86 wt/ht² and 12 boys (BMI 37.08 ± 3.17 wt/ht², aged between 15 and 19 years old, was evaluated to leptin, ghrelin and insulin concentrations, visceral adiposity and NAFLD through ultrasonography. The results showed a significant decrease in ghrelin, leptin concentrations and visceral

  20. DIRECT ETHOXYLATION OF GLYCEROL MONO OLEATE FROM PALM OIL DERIVATE AS A NOVEL NON-IONIC POLYMERIC SURFACTANT

    OpenAIRE

    2012-01-01

    The work investigates ethoxylation of glycerol mono oleate (GMO) performed in the presence of an alkaline catalyst. Glycerol mono oleate applied was derivated from Indonesian palm oil. The reaction was conducted with variation of Glycerol mono oleate : ethylene oxide ratio, temperature, and catalyst concentration. Forier Transform Infra Red (FTIR) and Nuclear Magnetic Resonance (NMR) analysis showed products with degrees of ethoxylation n=2 and n=3. FTIR analysis of products gave a new peak a...

  1. 40 CFR 721.3130 - Sulfuric acid, mono-C9-11-alkyl esters, sodium salts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sulfuric acid, mono-C9-11-alkyl esters... Specific Chemical Substances § 721.3130 Sulfuric acid, mono-C9-11-alkyl esters, sodium salts. (a) Chemical... acid, mono-C9-11-alkyl esters, sodium salts (PMN P-01-149; CAS No. 84501-49-5) is subject to...

  2. High resolution seismic reflection profiles of Holocene volcanic and tectonic features, Mono Lake, California

    Science.gov (United States)

    Jayko, A. S.; Hart, P. E.; Bursik, M. I.; McClain, J. S.; Moore, J. C.; Boyle, M.; Childs, J. R.; Novick, M.; Hill, D. P.; Mangan, M.; Roeske, S.

    2009-12-01

    The Inyo-Mono Craters of Long Valley and Mono Basin, California are the youngest eruptive vents of the Great Basin, USA and the second youngest in California. They are one of two seismically active volcanic centers with geothermal power production in the Walker Lane, western Great Basin, the other being the Coso Volcanic Field to the south. High resolution seismic reflection data collected from the northern tip of the Mono Craters eruptive centers in Mono Lake delinates two structural zones proximal to the active volcanic centers in Mono Lake. A growth structure drapped by ~30 m or more of bedded sediment shows increasing deformation and offset of clastic deposits on the northwest margin of the basin. Coherent thin-bedded stratigraphic sections with strong reflectors to 30-100m depth are preserved on the western and northern margins of the basin. The southern and southeastern areas of the lake are generally seismically opaque, due to extensive ash and tephra deposits as well as widespread methane. Thin pockets of well-bedded, poorly consolidated sediment of probable Holocene and last glacial age are present within intrabasin depressions providing some local age constraints on surfaces adjacent to volcanic vents and volcanically modified features.

  3. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Riou, Laurent; Ghezzi, Catherine [Universite Joseph Fourier, Grenoble (France); INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Poillot, Cathy; Cestele, Sandrine [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Desruet, Marie-Dominique [INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Couvet, Morgane; Bourgoin, Sandrine; Seve, Michel [CRI-INSERM U823, Grenoble (France). Inst. of Albert Bonniot; Universite Joseph Fourier, Grenoble (France); Waard, Michel de [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Smartox Biotechnologies, Grenoble (France)

    2014-07-01

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen {sup registered} or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H{sub 2}O{sub 2} was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  4. MAGNESIUM MONO POTASSIUM PHOSPHATE GROUT FOR P-REACTOR VESSEL IN-SITU DECOMISSIONING

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Stefanko, D.

    2011-01-05

    The objective of this report is to document laboratory testing of magnesium mono potassium phosphate grouts for P-Reactor vessel in-situ decommissioning. Magnesium mono potassium phosphate cement-based grout was identified as candidate material for filling (physically stabilizing) the 105-P Reactor vessel (RV) because it is less alkaline than portland cement-based grout (pH of about 12.4). A less alkaline material ({<=} 10.5) was desired to address a potential materials compatibility issue caused by corrosion of aluminum metal in highly alkaline environments such as that encountered in portland cement grouts. Information concerning access points into the P-Reactor vessel and amount of aluminum metal in the vessel is provided elsewhere. Fresh and cured properties were measured for: (1) commercially blended magnesium mono potassium phosphate packaged grouts, (2) commercially available binders blended with inert fillers at SRNL, (3) grouts prepared from technical grade MgO and KH{sub 2}PO{sub 4} and inert fillers (quartz sands, Class F fly ash), and (4) Ceramicrete{reg_sign} magnesium mono potassium phosphate-based grouts prepared at Argonne National Laboratory. Boric acid was evaluated as a set retarder in the magnesium mono potassium phosphate mixes.

  5. Efeitos de misturas de napropamide e simazine no controle de mono e dicotiledoneas em cafeeiros novos Effects of napropamide and simazine mixtures on the control of mono and dicotyledon on new coffee trees

    Directory of Open Access Journals (Sweden)

    L.S.P. Cruz

    1980-12-01

    : napropamide at 2.00 and 3.00 kg/ha; simazine at 0.50 and 0.75 kg/ha; and tank mixtures of 2.00 kg/ha of napropamide with 0.50 and 0.75 kg/ha of simazine; and 3.00 kg/ha of napropamide also with 0.50 and 0.75 kg/ha of simazine. A treatment without herbicide was also included in the experiment. A weed count was done 45 days after the aplication of the herbicides, and every 15 days until the 90th day, visual observations were done to detect the percentage of weed infestations. At that time it was also done on the fitotoxicity symptoms caused by herbicides on the coffee trees. The most frequent weeds present in the trial were, Digitaria horizontalis Willd. Eleusine indica (L . Gaertn, Amaranthus viridis L. and Bidens pilosa L. As it was expected, the mixtures were much more effective than those alone. The mixtures were rather effective in the control of mono and dycotyledons which were present in the experiment. Al treatments with 0.75 kg/ha of simazine presented light symptoms of fitotoxicity, limited to some leaves of the coffee trees, till last observation.

  6. Mono-X Versus Direct Searches: Simplified Models for Dark Matter at the LHC

    CERN Document Server

    Liew, Seng Pei; Vichi, Alessandro; Zurek, Kathryn M

    2016-01-01

    We consider simplified models for dark matter (DM) at the LHC, focused on mono-Higgs, -Z, -W or -b produced in the final state. Our primary purpose is to study the LHC reach of a relatively complete set of simplified models for these final states, while comparing the reach of the mono-X DM search against direct searches for the mediating particle. We find that direct searches for the mediating particle, whether in di-jets, jets+MET, multi-b+MET, or di-boson+MET, are usually stronger. We draw attention to the cases that the mono-X search is strongest, which include regions of parameter space in inelastic DM, two Higgs doublet, and squark mediated production models with a compressed spectrum.

  7. Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

    Directory of Open Access Journals (Sweden)

    Feng Xie

    2014-10-01

    Full Text Available TGF-β(transforming growth factor-β superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD(drosophila mothers against decapentaplegic protein proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several studies also uncovered mono-ubiquitination of SMADs as a mechanism for SMAD activation or inactivation. Mono-ubiquitination and subsequent deubiquitination of SMAD proteins accordingly play important roles in the control of TGF-β superfamily signaling. This review highlights the major pathways regulated by SMAD mono-ubiquitination.

  8. Second- and third-order nonlinear optical properties of unsubstituted and mono-substituted chalcones

    Science.gov (United States)

    Abegão, Luis M. G.; Fonseca, Ruben D.; Santos, Francisco A.; Souza, Gabriela B.; Barreiros, André Luis B. S.; Barreiros, Marizeth L.; Alencar, M. A. R. C.; Mendonça, Cleber R.; Silva, Daniel L.; De Boni, Leonardo; Rodrigues, J. J.

    2016-03-01

    This work describes the second and third orders of nonlinear optics properties of unsubstituted chalcone (C15H12O) and mono-substituted chalcone (C16H14O2) in solution, using hyper-Rayleigh scattering and Z-Scan techniques to determine the first molecular hyperpolarizability (β) and the two-photon absorption (2PA) cross section respectively. β Values of 25.4 × 10-30 esu and 31.6 × 10-30 esu, for unsubstituted and mono-substituted chalcone, respectively, dissolved in methanol have been obtained. The highest values of 2PA cross-sections obtained were 9 GM and 14 GM for unsubstituted and mono-substituted chalcone, respectively. The experimental 2PA cross sections obtained for each chalcone are in good agreement with theoretical results.

  9. A study on synthesis and oxidation mechanism of mono-alkyl phosphate

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Oxidation of white phosphorus by peroxides to produce mono-alkyl phosphate in the alcoholic solution has been studied under non-and catalytic conditions. In this paper,the mechanism of the oxidation process was analyzed. The content of mono-alkyl phosphate in the product is affected by different types of alcoholic solution and peroxide solvent. The result shows the availability of the following order for the activity of the peroxide solvent and alcoholic solutions-tert-butyl hydroperoxide>(di) benzoyl perox...

  10. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  11. Extracting the complex optical conductivity of mono- and bilayer graphene by ellipsometry

    Science.gov (United States)

    Chang, You-Chia; Liu, Chang-Hua; Liu, Che-Hung; Zhong, Zhaohui; Norris, Theodore B.

    2014-06-01

    A method for analysis of spectroscopic ellipsometry data is demonstrated to extract the optical conductivity of mono- and bilayer chemical-vapor-deposited graphene. We model graphene as a truly two-dimensional (2D) material with a sheet conductivity, rather than a phenomenological effective refractive index as has been used in the literature. This technique measures both the real and imaginary part of the optical conductivity, which is important for graphene optoelectronics and metamaterials. Using this method, we obtain broadband measurements of the complex optical conductivity for mono- and bilayer graphene from ultraviolet to mid-infrared wavelengths. We also study how chemical doping with nitric acid modifies the complex optical conductivity.

  12. Ultrasonication of pyrogenic microorganisms improves the detection of pyrogens in the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    of the assay. The interleukin-6 inducing capacity of a broad spectrum of UV-killed and ultrasonicated microorganisms is examined in Mono Mac 6 cells. The interleukin-6 secretion is determined in a sandwich immunoassay (DELFIA). The Mono Mac 6 assay is able to detect UV-killed Bacillus subtilis, Staphylococcus...... aureus and Salmonella typhimurium, but neither Candida albicans nor Aspergillus niger. After ultrasonication of the microorganisms it is possible to detect C. albicans and A. niger. The interleukin-6 inducing ability of the examined microorganisms is in no case reduced after ultrasonic treatment. However...

  13. Análises morfoquantitativa e do código químico do receptor purinérgico P2X2 no plexo mioentérico do íleo de camundongos obesos fêmeas e machos (ob/ob).

    OpenAIRE

    Márcia Sanae Mizuno

    2010-01-01

    As atividades intestinais são coordenadas pelo sistema nervoso entérico e, disfunções na motilidade intestinal são observadas em indivíduos obesos. O ATP é um co-transmissor e seus receptores estão distribuídos nos neurônios entéricos constituindo a família P2X e P2Y. O presente estudo tem como objetivo analisar a expressão do receptor P2X2 e o código químico nos neurônios mioentéricos na obesidade. Foram utilizados íleo de camundongos obesos machos (OBM) e fêmeas (OBF) (C57BL/6J ob/ob), e co...

  14. A full-vector paleomagnetic secular variation record (PSV) from Pyramid Lake (Nevada) from 47-17 ka: Evidence for the successive Mono Lake and Laschamp Excursions

    Science.gov (United States)

    Lund, S.; Benson, L.; Negrini, R.; Liddicoat, J.; Mensing, S.

    2017-01-01

    We have carried out a paleomagnetic study of late-Pleistocene Pyramid Lake core PLC08-1 (1680 cm). Our goals were to develop a full-vector paleomagnetic secular variation (PSV) record for the core, establish a paleomagnetic chronostratigraphy for the lake based on correlation of the PSV record to other dated PSV records in the region, compare that chronostratigraphy with previously developed radiocarbon and ash chronologies, and search for evidence of the Mono Lake Excursion and Laschamp Excursion. We have recovered a full-vector PSV record (inclination, declination, relative paleointensity) for the interval 47 ka to 17 ka. Twenty radiocarbon dates and four dated ashes provided a chronostratigraphic framework for this record. We have also used the link between our PSV and other dated PSV records to develop an independent PSV chronostratigraphy for the core. The PSV chronostratigraphy is not significantly different from that estimated by the radiocarbon and ash chronologies. We note the existence of two intervals of anomalous paleomagnetic directions. The younger interval, centered at 34.1 ± 0.4 ka, has the characteristic vector component features of the Mono Lake Excursion. The older interval, centered at 40.9 ± 0.5 ka, has the characteristic paleomagnetic signature of the Laschamp Excursion. This is the first time both intervals of excursional behavior have been found in the same sediment record from the western USA. Our new PSV record also corroborates previous estimates of the Mono Lake Excursion directional field behavior (Liddicoat and Coe, 1979) and age (Benson et al., 2003).

  15. Crianças e adolescentes obesos: dois anos de acompanhamento interdisciplinar Obese children and adolescents: two years of interdisciplinary follow-up

    Directory of Open Access Journals (Sweden)

    Mariana Porto Zambon

    2008-06-01

    Full Text Available OBJETIVO: Avaliar dois anos de seguimento de crianças e adolescentes obesos em ambulatório especializado. MÉTODOS: Trata-se de coorte, com coleta retrospectiva dos dados de 150 pacientes (1 a 19 anos de idade do Ambulatório de Obesidade do Hospital de Clínicas da Universidade Estadual de Campinas. Destes pacientes, 53% eram do sexo masculino e 63% eram de Campinas, São Paulo. A média da idade no início de ganho de peso foi 4,3 anos. Dos 150 pacientes, 128 retornaram uma vez, com avaliação de peso, altura, índice de massa corpórea (IMC e escores Z. Foram realizados hemograma, glicemia de jejum, insulina basal, relação glicemia/insulina, triglicérides, colesterol total e frações. Os pacientes foram divididos em dois grupos, de acordo com o seguimento. Entre os grupos, foi analisada a diferença entre idade, sexo, procedência, idade de início, acantose nigricans e os escores Z de peso, altura e IMC, proporção de exames laboratoriais alterados e a diferença dos escores Z de IMC em relação à primeira consulta. RESULTADOS: Dos 128 pacientes, 57% permaneceram em seguimento, sendo que 114 retornaram pelo menos uma vez. Comparando os grupos, os moradores de Campinas foram os que mais abandonaram o ambulatório, sem diferenças em relação às demais variáveis clínicas, antropométricas e laboratoriais estudadas. Houve queda da média do escore Z do IMC em ambos os grupos, em relação à consulta inicial. CONCLUSÕES: Os pacientes deste estudo apresentaram redução da média do escore Z do IMC semelhante à literatura. Apesar do alto índice de abandono, não foram identificados fatores de risco que o justificassem, com exceção da procedência da criança.OBJECTIVE: To study two years follow-up of obese children and adolescents from a specialized out-patient clinic. METHODS: This cohort study with retrospective collection of data enrolled 150 patients (1 to 19 years old, 53% males, 63% from Campinas, São Paulo, Brazil, and

  16. Quality of life of obese patients submitted to bariatric surgery Calidad de vida en pacientes obesos sometidos a cirugía bariátrica

    Directory of Open Access Journals (Sweden)

    N. Barreto Villela

    2004-11-01

    pacientes con obesidad mórbida (OM se ve reducida dadas las restricciones que esta situación impone. Se considera que la cirugía bariátrica es un tratamiento eficaz para la OM puesto que conduce a una reducción notable y progresiva del peso. Perder peso, el consejo dietético adecuado y el seguimiento pueden favorecer una mejoría notable en la QOL. Objetivo: Evaluar el grado de QOL en pacientes con OM, antes y después de la cirugía bariátrica (gastroplastia reductora de Fobi-Capella. Casos, material y métodos: Noventa y cinco pacientes obesos mórbidos (IMC > 40 kg/m², o moderados (IMC 35 -39 kg/m² con comorbilidades, fueron vistos, seguidos y recibieron consejo por parte del personal de Nutrición, Psicología, Endocrinología y Cirugía del Federal University Bahia Hospital. El grupo I incluía individuos en la etapa prequirúrgica y el grupo II se componía de 29 pacientes distintos en una etapa posquirúrgica avanzada. A los pacientes del grupo II se les vio a los 6, 12 y más meses después de la cirugía bariátrica. Se utilizó el estudio de resultados médicos Short Form Health Survey (SF-36 para evaluar la QOL en este estudio. Se analizaron los datos utilizando el método no paramétrico de Mann-Whitney y el programa SPSS. Resultados: Se detectó una mejoría estadísticamente significativa en la QOL, en los aspectos de salud general, capacidad funcional y vitalidad. Se vio una mejoría progresiva en la forma física, particularmente en los pacientes que habían sido sometidos a cirugía bariátrica en los últimos 12 meses, entre los 6 y 12 meses, y hacía más de 6 meses. Se vieron pequeños cambios en los puntos subjetivos. Se observó un cambio en los aspectos sociales tras una caída posquirúrgica. Esto explica el porqué los cambios no se ven cuando se comparan pacientes pre y posquirúrgicos. Conclusiones: La cirugía bariátrica de Fobi-Capella en nuestros pacientes con obesidad mórbida o con obesidad moderada y comorbilidades asociadas supuso

  17. Prevalência e gravidade de asma brônquica em adultos obesos com indicação de cirurgia bariátrica Prevalence and severity of asthma in obese adult candidates for bariatric surgery

    Directory of Open Access Journals (Sweden)

    Saulo Maia Davila Melo

    2011-06-01

    Full Text Available OBJETIVO: Determinar a prevalência de asma em um grupo de adultos obesos, candidatos a cirurgia bariátrica e avaliar a gravidade da asma neste grupo de pacientes. MÉTODOS: Estudo transversal, envolvendo 363 pacientes obesos adultos (índice de massa corpórea > 35 kg/m² avaliados por um médico pneumologista, utilizando a avaliação clínica como instrumento diagnóstico de asma. Todos os pacientes foram submetidos à avaliação clínica e espirometria e foram divididos em dois grupos (asma e controle. Os pacientes com asma foram classificados conforme a gravidade da doença. RESULTADOS: A prevalência de asma na população de obesos estudada foi de 18,5% (IC95%: 14,5-22,4. Essa prevalência nas mulheres e nos homens foi de 20,4% (IC95%: 16,2-24,5 e 13,7% (IC95%: 10,1-17,2, respectivamente. Havia sintomas de asma nos últimos doze meses em 8,0% (IC95%: 5,2-10,7, e houve manifestação inicial dos sintomas de asma na infância/adolescência em 17,4% (IC95%: 13,5-21,3. No grupo asma, asma intermitente estava presente em 29 pacientes (43,3%; asma persistente leve, em 7 (10,4%; asma moderada, em 25 (37,3%; e asma persistente grave, em 6 (9,0%. CONCLUSÕES: A prevalência de asma neste grupo de adultos obesos, utilizando-se a avaliação clínica como critério diagnóstico, mostrou-se elevada, com predomínio no sexo feminino e com manifestação inicial dos sintomas de asma na infância/adolescência. A gravidade da asma neste grupo de obesos adultos esteve entre os valores médios estimados para a população geral, com uma maior proporção de asma intermitente, asma persistente leve e asma persistente moderadaOBJECTIVE: To determine the prevalence of asthma in a group of obese adult candidates for bariatric surgery and to evaluate the severity of asthma in this group of patients. METHODS: This was a cross-sectional study involving 363 obese adults (body mass index > 35 kg/m² evaluated by a pulmonologist, using clinical evaluation as a

  18. Vitamina C restaura pressão arterial e a resposta vasodilatadora no antebraço em crianças obesas Vitamina C restaura presión arterial y respuesta vasodilatadora en el antebrazo en niños obesos Vitamin C restores blood pressure and vasodilator response during mental stress in obese children

    Directory of Open Access Journals (Sweden)

    Pricilla Regina Oliveira Fernandes Fernandes

    2011-06-01

    ónico de la suplementación de vitamina C (VitC sobre la presión arterial y en la respuesta vasodilatadora al estrés mental. MÉTODOS: En este estudio prospectivo, randomizado y doble ciego fueron evaluados niños obesos, de ambos géneros, con edades entre 8 y 12 años divididos en 2 grupos: 1 grupo de niños suplementados con 500 mg de vitamina C (n = 11 y, 2 substancia placebo (n = 10 durante 45 días. Ocho niños eutróficos, pareados por edad también fueron incluidos en el estudio. Fueron evaluados la presión arterial media (PAM, la frecuencia cardíaca (ECG y el flujo sanguíneo en el antebrazo por plestimografía de oclusión venosa. La conductancia vascular en el antebrazo (CVA fue obtenida por medio de la relación entre el flujo sanguíneo en el antebrazo y la PAM (X100. RESULTADOS: Antes de la intervención, los niños obesos presentaron PAM mayor y CVA menor cuando fueron comparados con el Grupo C. Post intervención, el Grupo VitC presentó reducción de la PAM en reposo (81 ± 2 vs 75 ± 1 mmHg, p = 0,01, mientras en el Grupo Placebo no hubo alteración de la PAM (p = 0,58. Adicionalmente, VitC promovió un aumento de la CVA en reposo (3,40 ± 0,5 vs 5,09 ± 0,6 un, p = 0,04 y durante el estrés mental (3,92 ± 0,5 vs 6,68 ± 0,9 un, p = 0,03. Además de eso, post suplementación con VitC, los niveles de la CVA fueron estadísticamente semejantes a los del Grupo C en reposo (5,09 ± 0,6 vs 5,82 ± 0,4 un, p > 0,05 y durante el estrés mental (6,68 ± 0,9 vs 7,35 ± 0,5 un, p > 0,05. CONCLUSIÓN: Suplementación con VitC redujo la presión arterial y restableció la respuesta vasodilatadora periférica en niños obesos.BACKGROUND: Peripheral vasodilation response plays an important role in the pathophysiology of obesity and heart disease. OBJECTIVE: To evaluate the chronic effect of vitamin C (VitC supplementation on blood pressure and on vasodilation response to mental stress. METHODS: In a double-blind, randomized and prospective study we evaluated obese

  19. Polyurethane triblock copolymers with mono-disperse hard segments. Influence of the hard segment length on thermal and thermomechanical properties

    NARCIS (Netherlands)

    Arun, Araichimani; Baack, Kasper K.J.; Gaymans, Reinoud J.

    2008-01-01

    Polyurethane triblock copolymers were synthesized by reacting 4,4-methylenebis(phenyl isocyanate) (MDI)-endcapped poly(tetramethylene oxide) (PTMO) with mono-amine-amide (MMA) units. Four different MMA units were used, i.e. no-amide (6m), mono-amide (6B), di-amide (6T6m) and tri-amide (6T6B), based

  20. 40 CFR 721.1950 - 2-Butenedioic acid (Z), mono(2-((1-oxopropenyloxy)ethyl) ester .

    Science.gov (United States)

    2010-07-01

    ...-oxopropenyloxy)ethyl) ester . 721.1950 Section 721.1950 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Specific Chemical Substances § 721.1950 2-Butenedioic acid (Z), mono(2-((1-oxopropenyloxy)ethyl) ester . (a... 2-butenedioic acid (Z), mono(2-((1-oxopropenyloxy)ethyl) ester (PMN P-85-543) is subject...

  1. The Mono Lake geomagnetic excursion recorded in loess: Its application as time marker and implications for its geomagnetic nature

    Science.gov (United States)

    Hambach, U.; Hark, M.; Zeeden, C.; Reddersen, B.; Zöller, L.; Fuchs, M.

    2009-04-01

    One of the youngest and worldwide documented geomagnetic excursions in the Brunhes Chron is the Mono Lake excursion (MLE). It has been detected in marine and terrestrial sedimentary archives as well as in lavas. Recent age determinations and age estimates for the MLE centre around an age interval of approximately 31 - 34 ka. Likewise the Laschamp excursion the MLE goes along with a distinct peak in cosmogenic radionuclides in ice cores and sedimentary archives. It provides therefore an additional geomagnetic time marker for various geoarchives to synchronise different climate archives. Here we report on a detailed record of the MLE from a loess site at Krems, Lower Austria. The site is situated on the southern slope of the Wachtberg hill in the vicinity of the old city centre of Krems. The archive comprises Middle to Upper Würmian (Late Pleistocene) loess in which an Upper Palaeolithic (Early Gravettian) cultural layer is embedded. The most spectacular finds are a double infant burial found in 2005 and a single burial discovered in 2006 (Einwögerer et al., 2006). Generally, archaeological findings show an extraordinarily good preservation due to embedding in rapidly sedimented loess (Händel et al., 2008). The about 10 m thick loess pile consists of calcareous sandy, coarse silt which is rich in mica indicating local sources. It is well stratified with brownish horizons representing embryonic soils pointing to incipient pedogenesis. Some of the pedo-horizons show occasionally indications of minor erosion and bedding-parallel sediment transport, but no linear erosional features. Pale greyish horizons are the result of partial gleying under permafrost conditions. No strong pedogenesis including decalcification and clay formation is present. The cultural layer is still covered by more than 5 m of loess, and dated by radiocarbon to ~27 ka 14C BP (Einwögerer et al., 2006). Below this layer up to 2.5 m of loess resting on Lower Pleistocene fluvial gravels are

  2. Variação do diâmetro da artéria braquial em crianças obesas: presente e futuro Variación del diámetro de la arteria braquial en niños obesos: presente y futuro Variation of the brachial artery diameter in obese children: present and future

    Directory of Open Access Journals (Sweden)

    Karla Cristina M. Costa

    2012-09-01

    Full Text Available OBJETIVO: Revisão da literatura acerca do uso da medida da variação do diâmetro da artéria braquial por ultrassonografia de alta resolução (dilatação mediada por fluxo como preditor de risco para doença cardiovascular em crianças e adolescentes obesos. FONTES DE DADOS: Levantamento de publicações indexadas no Medline/PubMed de trabalhos publicados entre 2002 e 2011, rastreadas com a combinação dos descritores: "endothelium", "child", "ultrasonography" e "obesity", além de estudos e textos clássicos sobre o tema. Foram encontradas 54 publicações e 32 delas foram incluídas na presente revisão do tema. SINTESE DOS DADOS: O estudo da disfunção endotelial tem sido empregado como preditor de risco para doenças cardiovasculares, tais como aterosclerose e doença cardíaca coronariana, visto que a lesão endotelial é um importante evento na fisiopatologia de tais doenças. CONCLUSÕES: A dilatação mediada por fluxo da artéria braquial mostra-se importante como ferramenta diagnóstica e prognóstica na avaliação da função endotelial de crianças e adolescentes com excesso de peso por ser um método não invasivo, com boa aplicabilidade quanto ao custo, à inocuidade e ao benefício.OBJETIVO: Revisión de la literatura sobre el uso de la medida de la variación del diámetro de la arteria braquial, por ultrasonografía de alta resolución (dilatación mediada por flujo, como predictor de riesgo para enfermedad cardiovascular en niños y adolescentes obesos. FUENTES DE DATOS: Inventario de publicaciones indizadas en Medline/Pubmed de trabajos publicados entre 2002 y 2011, buscadas mediante la combinación de los descriptores: «endothelium», «child», «ultrasonography» y «obesity», además de estudios y textos clásicos sobre el tema. Se encontraron 54 publicaciones y 32 de ésas fueron incluidas en la presente revisión del tema. Síntesis de los datos: El estudio de la disfunción endotelial viene siendo empleado

  3. Synthesis of lanthanum tris (mono-i-octyl phthalate)and its thermal stability for polyvinyl chloride

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A novel type of thermal stabilizer-lanthanum tris (mono-i-octyl phthalate) (LTMP) was synthesized by double-decomposition reaction of sodium mono-i-octyl phthalate with lanthanum chloride at 60℃.Sodium mono-i-octyl phthalate was prepared by sodium hydrate and mono-i-octyl phthalate prepared by reaction of isooctyl alcohol and phthalic anhydride in the presence of sulfuric acid catalyst at 110 ℃. The yield of lanthanum tris (mono-i-octyl phthalate) is about 84.5%. Its thermal stabilities were measured by heat-ageing oven test when incorporated into PVC. The experimental results show that the heat stability time is about 40min at 190 ℃ when adding 3phr (per hundred resin) to PVC. The thermal stability of this product is better than that of Ca-Zn complex and basic lead salt stabilizers, and equal to that of dibutyltin dilaurate.

  4. Emotions in freely varying and mono-pitched vowels, acoustic and EGG analyses.

    Science.gov (United States)

    Waaramaa, Teija; Palo, Pertti; Kankare, Elina

    2015-12-01

    Vocal emotions are expressed either by speech or singing. The difference is that in singing the pitch is predetermined while in speech it may vary freely. It was of interest to study whether there were voice quality differences between freely varying and mono-pitched vowels expressed by professional actors. Given their profession, actors have to be able to express emotions both by speech and singing. Electroglottogram and acoustic analyses of emotional utterances embedded in expressions of freely varying vowels [a:], [i:], [u:] (96 samples) and mono-pitched protracted vowels (96 samples) were studied. Contact quotient (CQEGG) was calculated using 35%, 55%, and 80% threshold levels. Three different threshold levels were used in order to evaluate their effects on emotions. Genders were studied separately. The results suggested significant gender differences for CQEGG 80% threshold level. SPL, CQEGG, and F4 were used to convey emotions, but to a lesser degree, when F0 was predetermined. Moreover, females showed fewer significant variations than males. Both genders used more hypofunctional phonation type in mono-pitched utterances than in the expressions with freely varying pitch. The present material warrants further study of the interplay between CQEGG threshold levels and formant frequencies, and listening tests to investigate the perceptual value of the mono-pitched vowels in the communication of emotions.

  5. Chemostat modeling of Escherichia coli persistence in conventionalized mono-associated and streptomycin-treated mice

    DEFF Research Database (Denmark)

    Rang, C.; Midtvedt, T.; Molin, Søren;

    2001-01-01

    We have previously shown that Escherichia coli BJ4 has similar doubling time in mice that are mono-associated (having only the inoculated E. coli BJ4) or streptomycin-treated (having mainly gram-positive bacteria plus the inoculated E. coli BJ4). We also showed that when the mice were conventiona...

  6. Forced vibration and wave propagation in mono-coupled periodic structures

    DEFF Research Database (Denmark)

    Ohlrich, Mogens

    1986-01-01

    This paper describes the wave propagation and vibration characteristics of mono-coupled structures which are of spatially periodic nature. The receptance approach to periodic structure theory is applied to study undamped periodic systems with composite structural elements; particular emphasis...... of the determination of the junction-receptance. The influence of such a disorder is illustrated by a simple example...

  7. Bioconversion of Mono- and Sesquiterpenoids by Recombinant Human Cytochrome P450 Monooxygenases

    NARCIS (Netherlands)

    Julsing, Mattijs K.; Fichera, Mario A.; Malz, Frank; Ebbelaar, Monique; Bos, Rein; Woerdenbag, Herman J.; Quax, Wim J.; Kayser, Oliver

    2008-01-01

    Cytochrome P450 monooxygenases play an important role in the biosynthesis and metabolism of terpenoids. We explored the potential of recombinant human liver cytochrome P450 monooxygenases CYP1A2, CYP2C9, and CYP3A4, heterologously expressed in Escherichia coli, to convert mono- and sesquiterpenoids

  8. Classification of All Associative Mono-n-ary Algebras with 2 Elements

    Directory of Open Access Journals (Sweden)

    Stephan Dominique Andres

    2009-01-01

    of these associative mono--ary algebras with 2 elements for even ≥2 and 6 for odd ≥3. These algebras are described explicitly. It is shown that a similar result is impossible for algebras with at least 4 elements. An application concerning the assignment of a control bit to a string is given.

  9. Specific fluorescent detection of fibrillar α-synuclein using mono- and trimethine cyanine dyes

    NARCIS (Netherlands)

    Volkova, K.D.; Kovalska, V.B.; Balanda, A.O.; Losytskyy, M.Yu; Golub, A.G.; Vermeij, R.J.; Subramaniam, V.; Tolmachev, O.I.; Yarmoluk, S.M.

    2008-01-01

    With the aim of searching of novel amyloid-specific fluorescent probes the ability of series of mono- and trimethine cyanines based on benzothiazole, pyridine and quinoline heterocycle end groups to recognize fibrillar formations of α-synuclein (ASN) was studied. For the first time it was revealed t

  10. Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    Pharmaceutical products containing proteins cause problems in testing for endotoxin and pyrogens. Many proteins interfere with the LAL test and the proteins are immunogenic in rabbits. The monocytic cell line Mono Mac 6 is an alternative assay for detection of endotoxin and other pyrogens....

  11. Preparation of mono- and diacetyl 4,4′-dimethylbiphenyl and their corresponding carboxylic acids

    DEFF Research Database (Denmark)

    Titinchi, Salam J.J.; Kamounah, Fadhil S.; Abbo, Hanna S.

    2007-01-01

    dimethylbiphenyls. In chloroalkane or carbon disulfide solvent, the yields of isomers were in the order: 2 -> 3-; in nitromethane 3-isomer predominated. On the other hand diacetylation of the hydrocarbon gave only the 2,3′-diacetyl isomer. The mono- and di-ketones are converted to the corresponding carboxylic acids...

  12. Synthesis of hierarchical zeolites using an inexpensive mono-quaternary ammonium surfactant as mesoporogen.

    Science.gov (United States)

    Zhu, Xiaochun; Rohling, Roderigh; Filonenko, Georgy; Mezari, Brahim; Hofmann, Jan P; Asahina, Shunsuke; Hensen, Emiel J M

    2014-12-04

    A simple amphiphilic surfactant containing a mono-quaternary ammonium head group (N-methylpiperidine) is effective in imparting substantial mesoporosity during synthesis of SSZ-13 and ZSM-5 zeolites. Highly mesoporous SSZ-13 prepared in this manner shows greatly improved catalytic performance in the methanol-to-olefins reaction compared to bulk SSZ-13.

  13. De kwalitatieve en semikwantitatieve bepaling van 6-mono-acetylmorfine in de urine van druggebruikers (I)

    NARCIS (Netherlands)

    Derks HJGM; van Twillert K; Zomer G

    1984-01-01

    In dit rapport wordt een analytische methode beschreven voor de bepaling van 6-mono-acetylmorfine in urine. Deze metaboliet van heroine is een marker voor heroine-gebruik en de bepaling ervan kan gebruikt worden om het gebruik van heroine van dat van morfine te onderscheiden. De methode is gebasee

  14. The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats

    DEFF Research Database (Denmark)

    Dalgaard, M.; Nellemann, Christine Lydia; Lam, Henrik Rye;

    2001-01-01

    A single oral dose of 400 mg/kg body weight of mono(2-ethylhexyl)phthalate (MEHP), the testis toxic metabolite of di(2-ethylhexyl)phthalate. was given to 28-day-old male Wistar rats and the testis toxic effects were investigated 3, 6. and 12 h after exposure. Detachment and sloughing of germ cell...

  15. MONO-PULSE RADAR 3-D IMAGING TECHNIQUES FOR TARGET IN STEPPED TRACKING MODE

    Institute of Scientific and Technical Information of China (English)

    Zhang Tao; Ma Changzheng; Zhang Qun; Zhang Shouhong

    2002-01-01

    A method for mono-pulse radar 3-D imaging in stepped tracking mode is presented and the amplitude linear modulation of error signals in stepped tracking mode is analyzed with its compensation method followed, so the problem of precisely tracking of target is solved. Finally the validity of these methods is proven by the simulation results.

  16. Imaging the magmatic system of Mono Basin, California with magnetotellurics in three--dimensions

    Science.gov (United States)

    Peacock, Jared R.; Mangan, Margaret T.; McPhee, Darcy K.; Ponce, David A.

    2015-01-01

    A three–dimensional (3D) electrical resistivity model of Mono Basin in eastern California unveils a complex subsurface filled with zones of partial melt, fluid–filled fracture networks, cold plutons, and regional faults. In 2013, 62 broadband magnetotelluric (MT) stations were collected in an array around southeastern Mono Basin from which a 3D electrical resistivity model was created with a resolvable depth of 35 km. Multiple robust electrical resistivity features were found that correlate with existing geophysical observations. The most robust features are two 300 ± 50 km3 near-vertical conductive bodies (3–10 Ω·m) that underlie the southeast and north-eastern margin of Mono Craters below 10 km depth. These features are interpreted as magmatic crystal–melt mush zones of 15 ± 5% interstitial melt surrounded by hydrothermal fluids and are likely sources for Holocene eruptions. Two conductive east–dipping structures appear to connect each magma source region to the surface. A conductive arc–like structure (model of the magmatic system beneath Mono Craters to a depth of 30 km.

  17. Synthesis and photochromic behavior of mono-,and biphotochromic system linked by p-phenylene bridge

    Institute of Scientific and Technical Information of China (English)

    N.O.Mahmoodi; K.Tabatabaeian; A.Ghavidast

    2010-01-01

    The synthesis of mono- and bis-1,3-diazabicyclo[3.1.0]hex-3-ene derivatives with indole ring and p-phenylene spacer,which behave as photochromic materials,is reported.The structure-photochromic behavior relationship (SPBR) of the synthesized compounds has been analyzed.

  18. Upgrading of the Mono Media Filters in Water Treatment Plants by Changing Filter Media

    Directory of Open Access Journals (Sweden)

    L Rezaei

    2011-01-01

    Full Text Available "n "n "nBackground and Objectives:Dual media filters have two different layer beds consist of sand and Anthracite. Advantage of dual media filters is longer run duration and more filtration rate. The purpose of this study was to achieve a performable model to improve single media Filters in water treatment plants."nMaterials and Methods: in this cross-sectional study, two pilots; mono and dual media were made and in a 5 month period samples taking were done. Total samples taken from input and output of each pilot, was 40. The samples then introduced for the measurment of turbidity and total organic carbon. Meanwhile the filters head loss also quantified in 40 times head loss measurement was done."nResults: Average turbidity removal in mono and two layer pilots were 63 and 65 percent respectively. Average removal of Total Organic Carbon in mono and two media pilots were 40 and 66 percent respectively. Head loss in dual and single media pilots were 0 .68 and 1.15 m respectively."nConclusion: Although average torbidity removal disparity between two pilots was not significant the amount of total organic carbon removed was considerable. Average head loss in single media pilot was more than dual media type. Ratio of UFRV in dual media to mono media filter was 51:30 it shows that filtration rate capacity will be improved up to70 percent by changing media type.

  19. Literature review on cyclic lateral loading effects of mono-bucket foundations

    DEFF Research Database (Denmark)

    Kapitanov, Lachezar Rosenov; Duroska, Peter; Quirante, Cesar Antonio Garcia

    2016-01-01

    calculation is highly demanded at the different design phases. The intention of the current study is to present, review and summarize the existing techniques to assess the effect of cyclic loading on Mono-Bucket foundations while emphasizing the advantage and disadvantage of each of them. Additionally...

  20. Synthesis of Versatile Building Blocks through Asymmetric Hydrogenation of Functionalized Itaconic Acid Mono-Esters

    NARCIS (Netherlands)

    Hekking, Koen F.W.; Lefort, Laurent; Vries, André H.M. de; Delft, Floris L. van; Schoemaker, Hans E.; Vries, Johannes G. de; Rutjes, Floris P.J.T.

    2008-01-01

    The rhodium-catalyzed asymmetric hydrogenation of several β-substituted itaconic acid mono-esters, using a library of monodentate phosphoramidite and phosphite ligands is described. Two β-alkyl-substituted substrates were readily hydrogenated by the rhodium complex Rh(COD)2BF4 in combination with (S

  1. Síntesis de mono y diitaconatos de alquilo y arilo

    Directory of Open Access Journals (Sweden)

    Francisco J. Sánchez

    2011-10-01

    Full Text Available Se presenta una técnica para la síntesis en laboratorio de mono y diitaconatos y la separación de los mismos por extracción selectiva con solventes orgánicos. La pureza de los productos se determina por cromatografía en capa fina y por espectroscopia infrarroja.

  2. 76 FR 38026 - Diethylene Glycol Mono Butyl Ether; Exemption From the Requirement of a Tolerance

    Science.gov (United States)

    2011-06-29

    ... butyl ether, also a glycol ether differing in only one ethyl group from DEGBE. These data were used to... monobutyl ether, also a glycol ether differing only in one ethyl group. This data was used to assess the... AGENCY 40 CFR Part 180 Diethylene Glycol Mono Butyl Ether; Exemption From the Requirement of a...

  3. Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru.

    Directory of Open Access Journals (Sweden)

    Leonela Villegas

    Full Text Available Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes.A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Löwenstein-Jensen (LJ media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment.Of 1292 patients enrolled, 1039 (80% were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8% patients and rifampicin mono-resistance was present in 24 (2% patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR = 2.10; 95% confidence interval (CI: 1.1-4.1, and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95%CI: 1.9-47.8. Isoniazid mono-resistant patients had a higher risk of poor treatment outcomes including treatment failure (2/85, 2%, p-value<0.01 and death (4/85, 5%, p<0.02. Rifampicin mono-resistant patients had a higher risk of death (2/24, 8%, p<0.01.A high prevalence of isoniazid and rifampicin mono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes.

  4. Circulating adipocytokines in morbid obese patients, relation with cardiovascular risk factors and anthropometric parameters Adipocitoquinas circulantes en obesos mórbidos, relación con factores de riesgo cardiovascular y parámetros antropométricos

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2011-02-01

    Full Text Available Background: Obesity and insulin resistance are associated with cardiovascular risk factors, including adipocytokines. The aim of the present study was to explore the relation of circulating adipocytokines with cardiovascular risk and anthropometric parameters in morbid obese patients. Subjects: A population of 65 morbid obese patients was analyzed in a prospective way. A biochemical, anthropometric and dietary evaluation was realized. Results: In the multivariate analysis with resistin as dependent variable, the BMI remained in the model (F = 16.6; p Antecedentes: La obesidad y resistencia a la insulina se asocia con factores de riesgo cardiovascular, incluyendo adipocitoquinas. El objetivo del presente estudio fue explorar la relación de circulante adipocitoquinas con los p factores de riesgo cardiovascular y los parámetros antropométricos en pacientes obesos mórbidos. Pacientes: Una muestra de 65 pacientes obesos mórbidos se analizo de manera prospectiva. Se realizó a todos una bioquímica, estudio antropométrico y una evaluación dietética. Resultados: En el análisis multivariado con resistina como variable dependiente, el IMC se mantuvo en el modelo (F = 16,6, p < 0,05, con un aumento de 0,23 (IC 95%: 0,06-0,41 ng/ml con cada punto de índice de masa corporal. En un segundo modelo con la adiponectina como variable dependiente, la edad se mantuvo en el modelo (F = 4,46, p < 0,05, con un aumento de 3,62 (IC 95%: 0,05-7,21 ng/ml, con cada año. En el tercer modelo con la interleucina 6 como variable dependiente, el HOMA, la PCR y el peso se mantuvieron en el modelo (F = 8,8; p < 0,01, con un aumento de 0,26 (IC 95%: 0,05-0,47 pg/ml, con cada punto de HOMA, un aumento de 0,43 (IC 95%: 0,10-0,76 pg / ml con cada 1 mg/dl de PCR y un aumento de 0,13 (IC 95%: 0,05-0,21 pg/ml con cada kg de peso. En el cuarto modelo con TNF-alfa como variable dependiente; resistina, IL-6 y el peso se mantuvieron en el modelo (F = 5,2, p < 0,01, con un

  5. Modificações da qualidade de vida sexual de obesos submetidos à cirurgia de Fobi-Capella Changes the sexual quality of life of the obeses submitted Fobi-Capella gastroplasty surgery

    Directory of Open Access Journals (Sweden)

    Arakén Almeida de Araújo

    2009-02-01

    Full Text Available OBJETIVO: Analisar as modificações na qualidade de vida sexual de obesos, proporcionadas pela redução do peso corpóreo, após a realização da gastroplastia à Fobi-Capella. MÉTODOS: Estudo quantitativo, prospectivo e longitudinal com cortes transversais, realizado entre março de 2005 e março de 2007, com 21 obesos mórbidos. Critérios de inclusão: idade de 20 a 50 anos, índice de massa corpórea (IMC =40 Kg/m² e insucesso em tentativas de tratamento clínico para obesidade nos últimos dois anos. Coleta de dados clínicos em prontuários e aplicação de questionário específico com questões relativas à função sexual, realizadas antes e seis meses após a cirurgia. Os escores obtidos foram analisados com o auxilio do programa Epi-Info6, empregando o teste T de student para amostras pareadas. RESULTADOS: O valor total aumentou seis meses após a cirurgia em 76,19%, permaneceu inalterado em 14,29% e diminuiu em 9,52%. Os domínios referentes a função erétil e a relação sexual aumentaram em 71,42%, ao desejo sexual em 52,38% e ao orgasmo em 28,57%. A satisfação sexual aumentou em 57,14%. As médias do valor total e dos seus domínios antes e seis meses após a cirurgia, exceto aquelas referentes ao orgasmo e ao desejo sexual, apresentam diferenças estatisticamente significativas. CONCLUSÃO: A qualidade de vida sexual em homens obesos melhora após a realização da gastroplastia à Fobi-Capella. Evidenciaram-se modificações favoráveis na função sexual desses indivíduos após a perda de peso.OBJECTIVES: Examine changes in the quality of sexual life of men with morbid obesity offered by a reduction in body weight following Fobi-Capella gastroplasty. METHOD: A quantitative, prospective, longitudinal, cross-sectional study was carried out on 21 men with morbid obesity between March 2005 and March 2007. Inclusion criteria were: aged 20 to 50 years, body mass index (BMI = 40 kg/m² and failure in attempts of clinical

  6. Evaluation of efficacy, reliability, and tolerability of sibutramine in obese patients, with an echocardiographic study Avaliação da eficácia, segurança e tolerabilidade da sibutramina em obesos - estudo randomizado duplo-cego

    Directory of Open Access Journals (Sweden)

    Alfredo Halpern

    2002-06-01

    Full Text Available This is a double-blind, placebo-controlled study of the efficacy, safety, and tolerability of sibutramine in the management of obese patients for a 6-month period. METHOD: Sixty-one obese patients (BMI >30, 10%, we observed a weight loss of >5% in 40% of the patients on sibutramine compared with 12.9% in the placebo group. We also detected weight gain in 45.2% of the placebo group compared to 20% in the sibutramine group. The sibutramine group showed improvement in HDL- cholesterol values (increased by 17% and triglyceride values (decreased by 12.8%. This group also showed an increase in systolic blood pressure (6.7%, 5 mmHg. There were no changes in echocardiograms comparing the beginning and end of follow-up, and side effects did not lead to discontinuation of treatment. DISCUSSION: Sibutramine proved to be effective for weight loss providing an 8% loss of the initial weight. Compliance to prolonged treatment was good, and side effects did not result in discontinuation of treatment. These data confirmed the good efficacy, tolerability, and safety profiles of sibutramine for treatment of obesity.O presente estudo objetivou comparar a eficácia, segurança e tolerabilidade da sibutramina em pacientes obesos. MÉTODO: Selecionamos 61 pacientes obesos (3010% ocorreu perda de peso>5% em 40% dos pacientes em uso da sibutramina vs 12,9% no grupo placebo e ganho de peso em 45,2% dos pacientes em uso de placebo vs 20% no grupo sibutramina. No grupo sibutramina notamos melhora dos níveis de HDL-colesterol (aumento de 17% e triglicerídeos (diminuição de 12,8%, neste grupo ocorreu também um aumento da pressão arterial sistólica (6,7%-5mmHg. Não houve alteração entre os ecocardiogramas do início e final do acompanhamento e os efeitos adversos não levaram à descontinuação do tratamento. DISCUSSÃO: A sibutramina mostrou-se eficaz na redução de peso, proporcionando um perda de 8% em relação ao peso inicial. Houve boa adesão do paciente ao

  7. Imagem corporal, ansiedade e depressão em pacientes obesos submetidos à cirurgia bariátrica Body image, anxiety and depression in obese patients submitted to bariatric surgery

    Directory of Open Access Journals (Sweden)

    Sebastião Sousa Almeida

    2012-04-01

    Full Text Available Pacientes obesos mórbidos têm recorrido à cirurgia bariátrica como um recurso eficaz para perder peso. Entretanto, este procedimento pode causar alterações comportamentais significativas. O objetivo deste trabalho foi investigar os níveis de ansiedade e depressão, assim como as mudanças sofridas na percepção da imagem corporal em pacientes obesos submetidos à cirurgia bariátrica em três momentos: pré-operatório, 6 meses e 12 meses após a cirurgia. Trata-se de um estudo do tipo prospectivo longitudinal, de abordagem quantitativa. No estudo foram aplicados os Inventários de Depressão e Ansiedade de Beck e a Escala Brasileira de Figuras de Silhuetas para Adultos. A cirurgia diminuiu significativamente tanto o índice de massa corporal dos pacientes quanto a insatisfação com a sua imagem corporal. Essa perda de peso e diminuição da insatisfação com a imagem corporal foi acompanhada de redução nos níveis de ansiedade e depressão, o que sugere que estes são fatores importantes no quadro obesidade.Morbidly obese patients often have resorted to bariatric surgery as an effective resource to be used for weight loss. However, this procedure can cause significant behavioral changes. The objective of this study was to investigate levels of anxiety and depression, as well as the changes suffered in the perception of body image in obese patients undergoing bariatric surgery at three different times: preoperatively, 6 months and 12 months after surgery. This is a prospective longitudinal study of a quantitative approach. The study used the Beck Depression Inventory, the Beck Anxiety Inventory and the Brazilian Scale of Figures Silhouettes for Adults. Surgery significantly decreased both the body mass index of patients and dissatisfaction with their body image. This weight loss and decreased body image dissatisfaction was accompanied by reduced levels of anxiety and depression, suggesting that these are important factors in the

  8. Esteatose hepática não alcoólica: relação com a síndrome metabólica e os fatores de risco cardiovascular em adolescentes obesos

    Directory of Open Access Journals (Sweden)

    Wener Barbosa Resende

    2014-03-01

    Full Text Available Objetivo: Avaliar a associação entre esteatose hepática não alcoólica (EHNA, síndrome metabólica (SM e fatores de risco cardiovascular (FRCs em adolescentes obesos. Métodos: Estudo observacional do tipo transversal com abordagem quantitativa, realizado de junho a agosto de 2011. Os voluntários foram aleatoriamente selecionados e encaminhados para avaliação clínica no setor de endocrinologia e cardiologia do hospital de clínicas da Universidade Federal de Uberlândia. Participaram 34 adolescentes de 14 a 19 anos, acima do percentil 95 da curva de crescimento. A EHNA foi analisada por ultrassonografia. A SM e os FRCs foram identificados pelos critérios da International Diabetes Federation. Resultados: A amostra foi composta de 14 indivíduos do sexo masculino e 20 do sexo feminino, com idade (16,8±1,6 e índice de massa corporal (IMC (35,7±3,9. A ocorrência de EHNA e SM foi de 76,5% (n=26 e 50% (n=17, respectivamente. O sexo masculino apresentou maior ocorrência de EHNA (78,6%, n=11, SM (64,3%, n=09 e associação de EHNA com SM (50%, n=07. Em relação aos FRCs 100% (n=34, 61,8% (n=21 e 52,9% (n=18 dos adolescentes apresentaram valores aumentados da circunferência da cintura (CC, da lowdensity- lipoprotein cholesterol (LDL-C e pressão arterial sistólica (PAS, respectivamente, e 52,9% (n=18 apresentaram baixos valores de high-density lipoprotein cholesterol (HDL-C. Houve correlações entre SM e triglicerídeos, PAS e diastólica e HDL-C, e entre EHNA, IMC e CC. Conclusão: Observou-se uma alta ocorrência de EHNA, SM e FRCs em adolescentes obesos. Uma forte correlação foi observada entre EHNA e SM, e entre FRCs com EHNA e SM.

  9. Índice glicêmico e carga glicêmica de dietas consumidas por indivíduos obesos Glycemic index and glycemic load of diets consumed by obese individuals

    Directory of Open Access Journals (Sweden)

    Helena Alves de Carvalho Sampaio

    2007-12-01

    Full Text Available OBJETIVO: Avaliar o índice glicêmico e a carga glicêmica de dietas de indivíduos obesos. MÉTODOS: Trata-se de estudo retrospectivo, que analisou as fichas clínicas de 80 adultos obesos, acompanhados em um serviço privado localizado em Fortaleza, Ceará. Determinaram-se o índice glicêmico e a carga glicêmica da dieta. Para verificação da associação entre índice glicêmico e carga glicêmica, e dessas variáveis com a ingestão energética diária e com o índice de massa corporal dos indivíduos, utilizou-se o teste de correlação de Pearson. O teste "t" de Student foi utilizado para verificar diferenças entre os dois índices e o sexo. Em ambos os testes adotou-se pOBJECTIVE: To evaluate the glycemic index and glycemic load of diets of obese individuals. METHODS: This is a retrospective study that analyzed the medical records of 80 obese adults attending a private health care service in Fortaleza, Ceará. The glycemic index and load of their diet was determined. The Pearson correlation test was used to verify if there was an association between glycemic index and glycemic load and of these variables with their daily energy intake and body mass index. The Student's "t" test was used to verify the differences between the two indexes and gender. A significance level of p<0.05 was adopted for both tests. RESULTS: Inadequate (moderate or high glycemic index prevailed at breakfast (82.9%, afternoon snack (60.0% and dinner (64.6%. The daily glycemic index was inadequate for 78.7% of the group and predominantly moderate according to the mean found (59.23, however it was less inadequate than the daily glycemic load which was high (143.8 and worse among males. The body mass index of the group, in general and according to gender, was not associated with any of the indices. Daily energy intake was associated only with glycemic load, both generally and taking gender into account. CONCLUSION: The results point toward a higher glycemic load in

  10. 21 CFR 582.4101 - Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Diacetyl tartaric acid esters of mono- and... Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat-forming fatty acids. (a) Product. Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils,...

  11. AL Amyloidosis

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    Desport Estelle

    2012-08-01

    Full Text Available Abstract Definition of the disease AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig light chains (LC (most commonly of lambda isotype usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multiple myeloma or other B-cell lymphoproliferative disorders is unusual. The key event in the development of AL amyloidosis is the change in the secondary or tertiary structure of an abnormal monoclonal LC, which results in instable conformation. This conformational change is responsible for abnormal folding of the LC, rich in β leaves, which assemble into monomers that stack together to form amyloid fibrils. Epidemiology AL amyloidosis is the most common type of systemic amyloidois in developed countries with an estimated incidence of 9 cases/million inhabitant/year. The average age of diagnosed patients is 65 years and less than 10% of patients are under 50. Clinical description The clinical presentation is protean, because of the wide number of tissues or organs that may be affected. The most common presenting symptoms are asthenia and dyspnoea, which are poorly specific and may account for delayed diagnosis. Renal manifestations are the most frequent, affecting two thirds of patients at presentation. They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients. Heart involvement, which is present at diagnosis in more than 50% of patients, leading to restrictive cardiopathy, is the most serious complication and engages prognosis. Diagnostic methods The diagnosis relies on pathological examination of an involved site showing Congo red-positive amyloid deposits, with typical apple-green birefringence under polarized light, that stain positive with an anti-LC antibody by immunohistochemistry and

  12. Influência do treinamento aeróbio e anaeróbio na massa de gordura corporal de adolescentes obesos Influencia del entrenamiento aeróbico y anaeróbico en la masa grasa corporal de adolescentes obesos Influence of the aerobic and anaerobic training on the body fat mass in obese adolescents

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Fernandez

    2004-06-01

    Full Text Available O objetivo deste estudo foi verificar as influências do exercício aeróbio e anaeróbio na composição corporal de adolescentes obesos do sexo masculino. A amostra foi constituída de 28 adolescentes com idades entre 15 e 19 anos, que apresentavam obesidade grave. Os voluntários foram distribuídos aleatoriamente em três grupos: grupo I: exercício anaeróbio; grupo II: exercício aeróbio; e grupo III: controle. O grupo I realizou treinamento intervalado em cicloergômetro que consistiu de 12 "tiros" de 30" com máxima força e velocidade, pedalando com carga alta (0,8% do massa corporal x 25 watts e recuperação ativa de 3'; o grupo II realizou treinamento aeróbio em cicloergômetro pedalando com carga relativa ao limiar ventilatório por 50 minutos. Já o terceiro grupo funcionou como controle, sem atividade física. Todos os grupos tiveram orientação nutricional e o período de intervenção foi de 12 semanas (três meses. Os voluntários realizaram densitometria óssea com análise da composição corporal (DEXA e avaliações médicas e de aptidão física. Quando comparados os períodos inicial e final de intervenção foram observadas reduções nas variáveis massa corporal, IMC, na massa de gordura corporal total e de membros inferiores e na percentagem de gordura corporal de tronco nos grupos de exercício. Diferenças foram observadas entre os grupos I e III para os deltas percentuais de massa de gordura corporal total e de membros inferiores e na percentagem de gordura de membros inferiores. Os dados sugerem que o exercício físico, tanto aeróbio como anaeróbio, aliado à orientação nutricional, promove maior redução ponderal, quando comparado com a orientação nutricional somente, e que, neste estudo, o exercício anaeróbio foi mais eficiente para promover a diminuição da gordura corporal e da percentagem de gordura e o exercício aeróbio foi mais eficaz no sentido de preservar e/ou aumentar a massa magra e a

  13. Dust Generation Resulting from Desiccation of Playa Systems: Studies on Mono and Owens Lakes, California

    Science.gov (United States)

    Gill, Thomas Edward

    1995-01-01

    Playas, evaporites, and aeolian sediments frequently are linked components within the Earth system. Anthropogenic water diversions from terminal lakes form playas that release fugitive dust. These actions, documented worldwide, simulate aeolian processes activated during palaeoclimatic pluvial/interpluvial transitions, and have significant environmental impacts. Pluvial lakes Russell and Owens in North America's Great Basin preceded historic Mono and Owens Lakes, now desiccated by water diversions into dust-generating, evaporite -encrusted playas. Geochemical and hydrologic cycles acting on the Owens (Dry) Lake playa form three distinct crust types each year. Although initial dust production results from deflation of surface efflorescences after the playa dries, most aerosols are created by saltation abrasion of salt/silt/clay crusts at crust/ sand sheet contacts. The warm-season, clastic "cemented" crust is slowest to degrade into dust. If the playa surface is stabilized by an unbroken, non-efflorescent crust, dust formation is discouraged. When Mono Lake's surFace elevation does not exceed 1951 meters (6400 feet), similar processes will also generate dust from its saline lower playa. Six factors--related to wind, topography, groundwater, and sediments--control dust formation at both playas. These factors were combined into a statistical model relating suspended dust concentrations to playa/lake morphometry. The model shows the extent and severity of Mono Lake dust storms expands significantly below the surface level 6376 feet (1943.5 meters). X-ray diffraction analysis of Mono Basin soils, playa sediments, and aerosols demonstrates geochemical cycling of materials through land, air and water during Mono Lake's 1982 low stand. Soils and clastic playa sediments contain silicate minerals and tephra. Saline groundwater deposited calcite, halite, thenardite, gaylussite, burkeite and glauberite onto the lower playa. Aerosols contained silicate minerals (especially

  14. 1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  15. 1. Mono((8)annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono((8)annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono((8)annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  16. Inverter technology reduces energy consumption of compressors. The application of mono screw-type compressors; lnvertertechniek verlaagt energiegebruik compressoren. Monoschroefcompressoren breed toepasbaar

    Energy Technology Data Exchange (ETDEWEB)

    Meijer, W. [Daikin Airconditioning Nederland, Schiedam (Netherlands)

    2010-06-15

    Mono screw-type compressors have been used on a large scale for quite some time in cold water machines and heat pumps, but also in numerous industrial installations for cooling and freezing products. Next to HFCs there are also natural refrigerants such as ammonia, propane and CO2. Two innovative techniques are the asynchronous capacity control with slide and the inverter technique. [Dutch] Monoschroefcompressoren worden al geruime tijd op grote schaal toegepast in koudwatermachines en warmtepompen, maar ook in tal van industriele installaties voor het koelen en vriezen van producten. Hierbij is het mogelijk naast de HFK's te werken met natuurlijke koudemiddelen, zoals ammoniak, propaan en CO2. Twee innovatieve technieken zijn de asynchrone capaciteitsregeling met een schuif en de invertertechniek.

  17. Non-destructive elemental analysis of large meteorite samples by prompt gamma-ray neutron activation analysis with the internal mono-standard method.

    Science.gov (United States)

    Latif, Sk A; Oura, Y; Ebihara, M; Nakahara, H

    2013-11-01

    Prompt gamma-ray neutron activation analysis (PGNAA) using the internal mono-standard method was tested for its applicability to analyzing large solid samples including irregularly shaped meteorite samples. For evaluating the accuracy and precision of the method, large quantities of the Geological Survey of Japan standardized rock powders (JB-1a, JG-1a, and JP-1) were analyzed and 12 elements (B, Na, Mg, Al, Cl, K, Ca, Ti, Mn, Fe, Sm, and Gd) were determined by using Si as an internal standard element. Analytical results were mostly in agreement with literature values within 10 %. The precision of the method was also shown to be within 10 % (1σ) for most of these elements. The analytical procedure was then applied to four stony meteorites (Allende, Kimble County, Leedey, Lake Labyrinth) and four iron meteorites (Canyon Diablo, Toluca (Mexico), Toluca (Xiquipilco), Squaw Creek) consisting of large chunks or single slabs. For stony meteorites, major elements (Mg, Al, Si, S, Ca, and Ni), minor elements (Na and Mn) and trace element (B, Cl, K, Ti, Co, and Sm) were determined with adequate accuracy. For iron meteorites, results for the Co and Ni mass fractions determined are all consistent with corresponding literature values. After the analysis, it was confirmed that the residual radioactivity remaining in the sample after PGNAA was very low and decreased down to the background level. This study shows that PGNAA with the internal mono-standard method is highly practical for determining the elemental composition of large, irregularly shaped solid samples including meteorites.

  18. Prevenção da síndrome metabólica em crianças obesas: uma proposta de intervenção Prevención del síndrome metabólico en niños obesos: una propuesta de intervención Prevention of metabolic syndrome in obese children: a proposal of intervention

    Directory of Open Access Journals (Sweden)

    Camila Buonani

    2011-06-01

    Full Text Available OBJETIVO: Analisar o efeito de 12 semanas de intervenção envolvendo prática de atividade física, orientações alimentar e psicológica sobre fatores de risco para o desenvolvimento da síndrome metabólica em crianças e adolescentes obesos. MÉTODOS: Estudo longitudinal com 23 crianças e adolescentes obesos, com idade entre seis e 16 anos (12,0±3,2 anos. Foram mensurados: gordura corporal total e de tronco, glicemia, colesterol total e triglicérides, pressão arterial sistólica e diastólica. Os jovens foram submetidos a três sessões semanais de 60 minutos de exercício físico (atividades esportivas recreativas, ginástica, circuitos e caminhadas, durante 12 semanas. O teste do qui-quadrado foi usado para comparar dados categóricos daqueles que apresentaram valores acima das recomendações para cada fator de risco. O teste t para dados pareados foi aplicado para comparar os dois momentos do estudo. RESULTADOS: Em indivíduos com alterações metabólicas no início do estudo, observou-se, após a intervenção, a diminuição de 11,6% na glicemia (105 para 93mg/dL; p=0,046 e de 24,9% no triglicérides (217 para 163mg/dL; p=0,013; porém, não houve diferenças na pressão arterial e no colesterol total. CONCLUSÕES: O programa de exercício físico aplicado nas crianças e adolescentes foi eficiente para melhorar os valores de glicemia e triglicérides.OBJETIVO: Analizar el efecto de 12 semanas de intervención implicando práctica de actividad física, orientación alimentar y psicológica sobre factores de riesgo respecto al desarrollo del síndrome metabólico en niños y adolescentes obesos. MÉTODOS: Estudio longitudinal con 23 niños y adolescentes obsesos, con edad entre seis y 16 años (12,0±3,2 años. Se midió: grasa corporal total y de tronco, glucemia, colesterol total y triglicéridos, presión arterial sistólica y diastólica Los jóvenes fueron sometidos a tres sesiones semanales de 60 minutos de ejercicio f

  19. Rotavirus infection in children: mono-and combines forms, especially clinics and course

    Directory of Open Access Journals (Sweden)

    N. B. Denisyuk

    2012-01-01

    Full Text Available Analyzed 74 case histories of children under one year with rotavirus infection. The most commonly detected rotavirus gastroenteritis in the form of mono-and combined forms. Mono-infection in 78.3% of cases occurred in the moderate form with a leading syndrome in the form of gastroenteritis, severe dehydration proceeded with symptoms of varying severity. Mixed variants in 98.7% of cases are in the unfavorable premorbid background, in 42.8% of children were registered in the severe forms, and children younger than 6 months were erased within. The diagnosis of intestinal infection was confirmed by PCR, bacteriological and immunological methods.

  20. Resurrecting an unsalvageable lower incisor with a mono-block approach

    Directory of Open Access Journals (Sweden)

    Rachit Jain

    2015-01-01

    Full Text Available Contemporary techniques, as well as the availability of bioactive and adhesive materials in endodontics, have helped revivifying teeth that were deemed hopeless. These newer materials and techniques would enable the clinician: (a to predictably stop microbial activity (b to achieve a total corono-apical fluid tight seal and (c to strengthen mutilated teeth by obtaining intra-radicular reinforcement through mono-block effect. This case report demonstrates the successful treatment of a mutilated anterior tooth with the use of bioactive and adhesive materials to obtain a total seal and mono-block effect. This article also shows the use of a simple method in the placement of root filling cement into the root canal.

  1. Detection and Quantification of Crack in Composite Mono Leaf Spring by Vibration Parameters

    Science.gov (United States)

    Jamadar, Nagendra Iranna; Kivade, Sangshetty Bheemanna; Pedada, Sudhakara Rao

    2016-06-01

    Automobile industries focus for the components alternative to conventional materials with composites. There is high demand for enhanced performance and light weight. The emphasis is given for composite mono leaf spring as potential item as it is made up of glass fibre reinforced plastics despite they are sensitive to damages such as crack, delamination, de-bonding etc., occurred during either manufacturing or in service condition. These damages grow in progression and results in catastrophic failure. This work aims to deal with structural health monitoring to study and analyse the damage levels in composite mono leaf spring such as detection, location and quantification of damage. An experimental investigation has been carried out to evaluate presence and severity of damage by vibration parameters and validated with simulation.

  2. Synergistic extraction of praseodymium with 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester and 8-Hydroxyquinoline

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qian; WU Dong-bei; BAO Bo-rong

    2009-01-01

    The synergistic extraction of Pr3+ from hydrochloric medium using mixture of 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (P507, HL) and 8-Hydroxyquinoline (HQ) in heptane was investigated. The effect of equilibrium of aqueous acidity on extraction of Pr3+ was discussed. The effect of extractant concentraction, different diluents, equilibrium time and acetate ion concentration on extraction reaction were also studied. With a method of double-logarithmic slope, composition of the extracted species on 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester and 8-Hydroxyquinolinc was derived. The result shows that the synergistic extraction system not only overcomes emulsification of 8-Hydroxyquinoline, but also shows perfect capacity of synergistic extraction. The largest synergistic enhancement factor can be calculated to be 5.49 at pH 3.6 for Pr3+.

  3. Nonlinear Optical Properties of Novel Mono-O-Hydroxy Bidentate Schiff Base: Quantum Chemical Calculations

    Directory of Open Access Journals (Sweden)

    N. S. Labidi

    2013-01-01

    Full Text Available The semiempirical AM1 SCF method is used to study the first static hyperpolarizabilities β of some novel mono-O-Hydroxy bidentate Schiff base in which electron donating (D and electron accepting (A groups were introduced on either side of the Schiff base ring system. Geometries of all molecules were optimized at the semiempirical AM1. The first static hyperpolarizabilities of these molecules were calculated using Hyperchem package. To understand this phenomenon in the context of molecular orbital picture, we examined the molecular HOMO and molecular LUMO generated via Hyperchem. The study reveals that the mono-O-Hydroxy bidentate Schiff bases have large β values and hence in general may have potential applications in the development of nonlinear optical materials.

  4. Mono-layer BC2 a high capacity anode material for Li-ion batteries

    Science.gov (United States)

    Hardikar, Rahul; Samanta, Atanu; Han, Sang Soo; Lee, Kwang-Ryeol; Singh, Abhishek

    2015-04-01

    Mono-layer of graphene with high surface area compared to the bulk graphite phase, shows less Li uptake. The Li activity or kinetics can be modified via defects and/or substitutional doping. Boron and Nitrogen are the best known dopants for carbonaceous anode materials. In particular, boron doped graphene shows higher capacity and better Li adsorption compared to Nitrogen doped graphene. Here, using first principles density functional theory calculations, we study the spectrum of boron carbide (BCx) mono-layer phases in order to estimate the maximum gravimetric capacity that can be achieved by substitutional doping in graphene. Our results show that uniformly boron doped BC2 phase shows a high capacity of? 1400 mAh/g, much higher than previously reported capacity of BC3. Supported by Korea Institute of Science and Technology.

  5. Couple Control Model Implementation on Antagonistic Mono- and Bi-Articular Actuators

    CERN Document Server

    Prattico, Flavio; Yamamoto, Shin-ichiroh

    2014-01-01

    Recently, robot assisted therapy devices are increasingly used for spinal cord injury (SCI) rehabilitation in assisting handicapped patients to regain their impaired movements. Assistive robotic systems may not be able to cure or fully compensate impairments, but it should be able to assist certain impaired functions and ease movements. In this study, a couple control model for lower-limb orthosis of a body weight support gait training system is proposed. The developed leg orthosis implements the use of pneumatic artificial muscle as an actuation system. The pneumatic muscle was arranged antagonistically to form two pair of mono-articular muscles (i.e., hip and knee joints), and a pair of bi-articular actuators (i.e., rectus femoris and hamstring). The results of the proposed couple control model showed that, it was able to simultaneously control the antagonistic mono- and bi-articular actuators and sufficiently performed walking motion of the leg orthosis.

  6. Literature review on cyclic lateral loading effects of mono-bucket foundations

    DEFF Research Database (Denmark)

    Kapitanov, Lachezar Rosenov; Duroska, Peter; Garcia, Cesar Antonio Garcia

    2016-01-01

    The renewable offshore energy sector is currently growing rapidly and there is a vast interest in optimization of the design procedures for the offshores wind turbines. Mono-Bucket can be a breakthrough in the sphere of offshore wind turbines foundations due to its lightness and fast installation...... and consequently cost-effectiveness compared to other common solutions. The long-term cyclic loading can cause degradation of soil-bucket system stiffness, which yields into accumulated and permanent deformations. Despite of the advantages, there is no standard procedure to design the foundation especially...... for assessing the accumulated deformations under environmental longterm loading. However, numerical and semi-empirical methods already used for offshore foundations can be adopted to take into account the effect of cyclic loading on Mono-Buckets. Among them, load-displacement techniques as cyclic p-y curves...

  7. Experimental damping assessment of a full scale offshore mono bucket foundation

    DEFF Research Database (Denmark)

    Gres, Szymon; Fejerskov, Morten; Ibsen, Lars Bo;

    2016-01-01

    This paper quantifies the system damping of a offshore meteorological mast supported by a Mono Bucket foundation based on a long-term experimental campaign. The structure is located at Dogger Bank west, North Sea, and equipped with a measurement system monitoring acceleration, strain, inclination...... shows that the total damping ratio of the lowest eigenmode is normally distributed with mean value of 1.11% of critical damping. Linear correlation between the damping ratio and the significant wave height is observed....

  8. New concept research on mono-hull compounded ship form with high seakeeping performance

    Institute of Scientific and Technical Information of China (English)

    LIU Ya-dong; LI Ji-de; WANG Qing

    2003-01-01

    The seakeeping performance of a certain ship equipped with semi-submerged bow (SSB) and bow-fins is discussed. The numerical calculations are carried out on a 600t deep-V compound archetypal ship. The results show that the compounded ship form has excellent seakeeping performance and thus it establishes the theoretical foundations for the development of mono-hull compounded ship form with high seakeeping performance.

  9. First survey of fungi in hypersaline soil and water of Mono Lake area (California).

    Science.gov (United States)

    Steiman, Régine; Ford, Larry; Ducros, Véronique; Lafond, Jean-Luc; Guiraud, Pascale

    2004-01-01

    Mono Lake is a closed lake located in central California, east of the Sierra Nevada mountains. It contains dissolved carbonates, sulfates and chlorides at high concentrations. Due to its high salinity, Mono Lake was sometimes compared to the Dead Sea. However, it appears that Mono Lake water and vicinity abound with life. In this work, the fungal flora living in this extreme ecosystem was studied for the first time. Soil, tufa, water and sediment samples were also analyzed for their mineral and salt composition. Results showed that water was particularly rich in sodium, potassium, phosphorus and boron. Soil and sediments contained very high levels of calcium and magnesium, but also barium, boron and strontium. Sodium, phosphorus and iron levels varied in a large extent from one to another sample. Neutral to very alkaline pH were recorded. Water samples were found sterile in the conditions chosen for fungi isolation, while sediment, soil and tufa samples led to the isolation of a total of 67 fungal species (from 23 samples), belonging to various taxonomic groups. From our results no clear effects of the chemical parameters of the samples were observed on fungal life apart from the pH. The methods chosen did not allow the isolation of extremely halotolerant species. We isolated in this work a series of ubiquitous species, suggesting that a selection of resistant and/or adaptable strains of some common species could have occurred. Depending on the medium and the temperature of isolation, it can be hypothesized that some species were present as dormant structures, while some others, isolated at pH 8 on a medium enriched in Na and Ca, could be in a growing form adapted to alkaline and saline conditions. This work contributes to a better knowledge of the mycobiota present in the Mono Lake's ecosystem.

  10. Nonlinear Optical Properties of Novel Mono-O-Hydroxy Bidentate Schiff Base: Quantum Chemical Calculations

    OpenAIRE

    N. S. Labidi

    2013-01-01

    The semiempirical AM1 SCF method is used to study the first static hyperpolarizabilities β of some novel mono-O-Hydroxy bidentate Schiff base in which electron donating (D) and electron accepting (A) groups were introduced on either side of the Schiff base ring system. Geometries of all molecules were optimized at the semiempirical AM1. The first static hyperpolarizabilities of these molecules were calculated using Hyperchem package. To understand this phenomenon in the context of molecular o...

  11. Strength and nature of hydrogen bonding interactions in mono- and di-hydrated formamide complexes.

    Science.gov (United States)

    Angelina, Emilio L; Peruchena, Nélida M

    2011-05-12

    In this work, mono- and di-hydrated complexes of the formamide were studied. The calculations were performed at the MP2/6-311++G(d,p) level of approximation. The atoms in molecules theory (AIM), based on the topological properties of the electronic density distribution, was used to characterize the different types of bonds. The analysis of the hydrogen bonds (H-bonds) in the most stable mono- and di-hydrated formamide complexes shows a mutual reinforcement of the interactions, and some of these complexes can be considered as "bifunctional hydrogen bonding hydration complexes". In addition, we analyzed how the strength and the nature of the interactions, in mono-hydrated complexes, are modified by the presence of a second water molecule in di-hydrated formamide complexes. Structural changes, cooperativity, and electron density redistributions demonstrate that the H-bonds are stronger in the di-hydrated complexes than in the corresponding mono-hydrated complexes, wherein the σ- and π-electron delocalization were found. To explain the nature of such interactions, we carried out the atoms in molecules theory in conjunction with reduced variational space self-consistent field (RVS) decomposition analysis. On the basis of the local Virial theorem, the characteristics of the local electron energy density components at the bond critical points (BCPs) (the 1/4∇ (2)ρ(b) component of electron energy density and the kinetic energy density) were analyzed. These parameters were used in conjunction with the electron density and the Laplacian of the electron density to analyze the characteristics of the interactions. The analysis of the interaction energy components for the systems considered indicates that the strengthening of the hydrogen bonds is manifested by an increased contribution of the electrostatic energy component represented by the kinetic energy density at the BCP.

  12. SIMAC - A phosphoproteomic strategy for the rapid separation of mono-phosphorylated from multiply phosphorylated peptides

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Robinson, Phillip J

    2008-01-01

    spectrometric analysis, such as immobilized metal affinity chromatography or titanium dioxide the coverage of the phosphoproteome of a given sample is limited. Here we report a simple and rapid strategy - SIMAC - for sequential separation of mono-phosphorylated peptides and multiply phosphorylated peptides from...... and an optimized titanium dioxide chromatographic method. More than double the total number of identified phosphorylation sites was obtained with SIMAC, primarily from a three-fold increase in recovery of multiply phosphorylated peptides....

  13. Gas chromatographic analysis of synthetic glycidol esters, mono-, di- and triglycerides.

    Science.gov (United States)

    Engbersen, J A; van Stijn, F

    1976-03-01

    The gas chromatographic analysis of glycidol esters and mono-, di-,and triglycerides of palmitic-, stearic-, and oleic acid mixtures is described. The composition of the products was determined by gas chromatography on OV-17 after trimethylsilylation. Base-line separations between 1- and 2-monoglycerides and between 1,2- and 1,3-diglycerides were obtained. Isomerisation of the trimethylsilyl ethers of monoglycerides was not observed, contrary to published work.

  14. Dark Matter searches with Mono-X signatures at the ATLAS experiment

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00377126; The ATLAS collaboration

    2016-01-01

    At the LHC dark matter particles can be produced in association with Standard Model particles coming from initial state radiation. Searches for such processes using events with jets, photons or massive gauge bosons recoiling against large missing transverse momentum in ATLAS at 13 TeV are presented. These ``mono-X'' signatures provide powerful probes to dark matter production at the LHC, allowing for the interpretation of results in terms of simplified models with pair production of WIMPs.

  15. p-Type Quasi-Mono Silicon Solar Cell Fabricated by Ion Implantation

    Directory of Open Access Journals (Sweden)

    Chien-Ming Lee

    2013-01-01

    Full Text Available The p-type quasi-mono wafer is a novel type of silicon material that is processed using a seed directional solidification technique. This material is a promising alternative to traditional high-cost Czochralski (CZ and float-zone (FZ material. Here, we evaluate the application of an advanced solar cell process featuring a novel method of ion implantation on p-type quasi-mono silicon wafer. The ion implantation process has simplified the normal industrial process flow by eliminating two process steps: the removal of phosphosilicate glass (PSG and the junction isolation process that is required after the conventional thermal POCl3 diffusion process. Moreover, the good passivation performance of the ion implantation process improves Voc. Our results show that, after metallization and cofiring, an average cell efficiency of 18.55% can be achieved using 156 × 156 mm p-type quasi-mono silicon wafer. Furthermore, the absolute cell efficiency obtained using this method is 0.47% higher than that for the traditional POCl3 diffusion process.

  16. Fusion of agarase and neoagarobiose hydrolase for mono-sugar production from agar.

    Science.gov (United States)

    Alkotaini, Bassam; Han, Nam Soo; Kim, Beom Soo

    2017-02-01

    In enzymatic saccharification of agar, endo- and exo-agarases together with neoagarobiose hydrolase (NABH) are important key enzymes for the sequential hydrolysis reactions. In this study, a bifunctional endo/exo-agarase was fused with NABH for production of mono-sugars (D-galactose and 3,6-anhydro-L-galactose) from agar using only one fusion enzyme. Two fusion enzymes with either bifunctional agarase (Sco3476) or NABH (Zg4663) at the N-terminus, Sco3476-Zg4663 (SZ) and Zg4663-Sco3476 (ZS), were constructed. Both fusion enzymes exhibited their optimal agarase and NABH activities at 40 and 35 °C, respectively. Fusions SZ and ZS enhanced the thermostability of the NABH activity, while only fusion SZ showed a slight enhancement in the NABH catalytic efficiency (K cat/K M) from 14.8 (mg/mL)(-1) s(-1) to 15.8 (mg/mL)(-1) s(-1). Saccharification of agar using fusion SZ resulted in 2-fold higher mono-sugar production and 3-fold lower neoagarobiose accumulation when compared to the physical mixture of Sco3476 and Zg4663. Therefore, this fusion has the potential to reduce enzyme production cost, decrease intermediate accumulation, and increase mono-sugar yield in agar saccharification.

  17. Evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage.

    Science.gov (United States)

    Bartz, René; Seemann, Joachim; Zehmer, John K; Serrero, Ginette; Chapman, Kent D; Anderson, Richard G W; Liu, Pingsheng

    2007-08-01

    Mono-ADP-ribosylation is emerging as an important posttranslational modification that modulates a variety of cell signaling pathways. Here, we present evidence that mono-ADP-ribosylation of the transcriptional corepressor C terminal binding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lipid storage in droplets that are surrounded by a monolayer of phospholipid and associated proteins. CtBP1/BARS is an NAD-binding protein that becomes ribosylated when cells are exposed to BFA. Both endogenous lipid droplets and droplets enlarged by oleate treatment are lost after 12-h exposure to BFA. Lipid loss requires new protein synthesis, and it is blocked by multiple ribosylation inhibitors, but it is not stimulated by disruption of the Golgi apparatus or the endoplasmic reticulum unfolded protein response. Small interfering RNA knockdown of CtBP1/BARS mimics the effect of BFA, and mouse embryonic fibroblasts derived from embryos that are deficient in CtBP1/BARS seem to be defective in lipid accumulation. We conclude that mono-ADP-ribosylation of CtBP1/BARS inactivates its repressor function, which leads to the activation of genes that regulate neutral lipid storage.

  18. Modeling of point defects and rare gas incorporation in uranium mono-carbide

    Science.gov (United States)

    Chartier, A.; Van Brutzel, L.

    2007-02-01

    An embedded atom method (EAM) potential has been established for uranium mono-carbide. This EAM potential was fitted on structural properties of metallic uranium and uranium mono-carbide. The formation energies of point defects, as well as activation energies for self migration, have been evaluated in order to cross-check the suitability of the potential. Assuming that the carbon vacancies are the main defects in uranium mono-carbide compounds, the migration paths and energies are consistent with experimental data selected by Catlow[C.R.A. Catlow, J. Nucl. Mater. 60 (1976) 151]. The insertion and migration energies for He, Kr and Xe have also been evaluated with available inter-atomic potentials [H.H. Andersen, P. Sigmund, Nucl. Instr. and Meth. B 38 (1965) 238]. Results show that the most stable defect configuration for rare gases is within uranium vacancies. The migration energy of an interstitial Xe is 0.5 eV, in agreement with the experimental value of 0.5 eV [Hj. Matzke, Science of advanced LMFBR fuels, Solid State Physics, Chemistry and Technology of Carbides, Nitrides and Carbonitrides of Uranium and Plutonium, North-Holland, 1986].

  19. DIRECT ETHOXYLATION OF GLYCEROL MONO OLEATE FROM PALM OIL DERIVATE AS A NOVEL NON-IONIC POLYMERIC SURFACTANT

    Directory of Open Access Journals (Sweden)

    Joddy Arya Laksmono

    2012-01-01

    Full Text Available The work investigates ethoxylation of glycerol mono oleate (GMO performed in the presence of an alkaline catalyst. Glycerol mono oleate applied was derivated from Indonesian palm oil. The reaction was conducted with variation of Glycerol mono oleate : ethylene oxide ratio, temperature, and catalyst concentration. Forier Transform Infra Red (FTIR and Nuclear Magnetic Resonance (NMR analysis showed products with degrees of ethoxylation n=2 and n=3. FTIR analysis of products gave a new peak at 1570 cm-1 supporting that C-O-C bond was formed. New peaks were also observed in 13-C-NMR analysis of run 2 and run 3 with chemical shift of (δ 61.3385; 61.9108; 62.5117; 63.8566; 66.0982; 72.6127 and 61.2172; 63.2393; 65.9100; 72.5201, respectively. Glycerol mono oleate ethoxylated was yielded and could be useful for a novel non-ionic polymeric surfactant.

  20. Highly luminescent mono- and multilayers of immobilized CdTe nanocrystals: controlling optical properties through post chemical surface modification.

    Science.gov (United States)

    Tsuruoka, Takaaki; Takahashi, Rena; Nakamura, Toshihiro; Fujii, Minoru; Akamatsu, Kensuke; Nawafune, Hidemi

    2008-04-14

    The significant fluorescence enhancement of immobilized CdTe nanocrystals through chemical surface modifications is described, enabling us to fabricate stable, highly luminescent thin films and patterns of nanocrystal mono- and mutilayers.

  1. The synthesis of mono-6-thio-β-cyclodextrin capped CdTe QDs and its interaction with neutral red

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper presents a novel method for the synthesis of CdTe quantum dots (QDs) capped with β-cyclodextrin in aqueous solution using both TGA and mono-6-thio-β-CD as stabilizers.The interaction between mono-6-thio-β-CD-CdTe QDs and neutral red (NR) was studied with fluorescence,UV-absorption and the resonance Rayleigh scattering spectrum.When its concentration was over 7.5 × 10-6 mol/L,the neutral red began to aggregate on the surface of the mono-6-thio-β-CD-CdTe QDs,which resulted in the mono-6-thio-β-CD-CdTe QDs particle size increasing,the sharply quenched fluorescence,and the marked increase of RRS intensity.

  2. Symptoms and Immune Markers in Plasmodium/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru.

    Directory of Open Access Journals (Sweden)

    Eric S Halsey

    2016-04-01

    Full Text Available Malaria and dengue are two of the most common vector-borne diseases in the world, but co-infection is rarely described, and immunologic comparisons of co-infection with mono-infection are lacking.We collected symptom histories and blood specimens from subjects in a febrile illness surveillance study conducted in Iquitos and Puerto Maldonado, Peru, between 2002-2011. Nineteen symptoms and 18 immune markers at presentation were compared among those with co-infection with Plasmodium/dengue virus (DENV, Plasmodium mono-infection, and DENV mono-infection. Seventeen subjects were identified as having Plasmodium/DENV co-infection and were retrospectively matched with 51 DENV mono-infected and 44 Plasmodium mono-infected subjects. Those with Plasmodium mono-infection had higher levels of IL-4, IL-6, IL-10, IL-12, IL-13, IL-17A, IFN-γ, and MIP1-α/CCL3 compared with DENV mono-infection or co-infection; those with Plasmodium mono-infection had more cough than those with DENV mono-infection. Subjects with DENV mono-infection had higher levels of TGF-β1 and more myalgia than those with Plasmodium mono-infection. No symptom was more common and no immune marker level was higher in the co-infected group, which had similar findings to the DENV mono-infected subjects.Compared with mono-infection with either pathogen, Plasmodium/DENV co-infection was not associated with worse disease and resembled DENV mono-infection in both symptom frequency and immune marker level.

  3. Symptoms and Immune Markers in Plasmodium/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru

    Science.gov (United States)

    Halsey, Eric S.; Baldeviano, G. Christian; Edgel, Kimberly A.; Vilcarromero, Stalin; Sihuincha, Moises; Lescano, Andres G.

    2016-01-01

    Background Malaria and dengue are two of the most common vector-borne diseases in the world, but co-infection is rarely described, and immunologic comparisons of co-infection with mono-infection are lacking. Methodology and Principal Findings We collected symptom histories and blood specimens from subjects in a febrile illness surveillance study conducted in Iquitos and Puerto Maldonado, Peru, between 2002–2011. Nineteen symptoms and 18 immune markers at presentation were compared among those with co-infection with Plasmodium/dengue virus (DENV), Plasmodium mono-infection, and DENV mono-infection. Seventeen subjects were identified as having Plasmodium/DENV co-infection and were retrospectively matched with 51 DENV mono-infected and 44 Plasmodium mono-infected subjects. Those with Plasmodium mono-infection had higher levels of IL-4, IL-6, IL-10, IL-12, IL-13, IL-17A, IFN-γ, and MIP1-α/CCL3 compared with DENV mono-infection or co-infection; those with Plasmodium mono-infection had more cough than those with DENV mono-infection. Subjects with DENV mono-infection had higher levels of TGF-β1 and more myalgia than those with Plasmodium mono-infection. No symptom was more common and no immune marker level was higher in the co-infected group, which had similar findings to the DENV mono-infected subjects. Conclusions/Significance Compared with mono-infection with either pathogen, Plasmodium/DENV co-infection was not associated with worse disease and resembled DENV mono-infection in both symptom frequency and immune marker level. PMID:27128316

  4. Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis.

    Science.gov (United States)

    Kumar, Kewal; Liu, Nicole; Yang, Donald; Na, Daniel; Thompson, John; Wrischnik, Lisa A; Land, Kirkwood M; Kumar, Vipan

    2015-08-15

    A library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen Trichomonas vaginalis. The structure activity studies (SAR) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of T. vaginalis at approximately 10 μM with no visual effect on mammalian cells at the same concentration.

  5. Systemic lupus erythematosus patients contain significantly less igm against mono-methylated lysine than healthy subjects.

    Directory of Open Access Journals (Sweden)

    Sha Guo

    Full Text Available Post-translational modifications on proteins are important in biological processes but may create neo-epitopes that induce autoimmune responses. In this study, we measured the serum IgG and IgM response to a set of non-modified or acetyl- and methyl-modified peptides corresponding to residues 1-19 of the histone 3 N-terminal tail in systemic lupus erythematosus (SLE patients and healthy subjects. Our results indicated that the SLE patients and healthy subjects produced antibodies (Abs to the peptides, but the two groups had different Ab isotype and epitope preferences. Abs to the non-modified form, H31-19, were of the IgG isotype and produced by SLE patients. They could not recognize the scrambled H31-19, which contained the same amino acid composition but a different sequence as H31-19. In comparison, healthy subjects in general did not produce IgG against H31-19. However, about 70% of the healthy subjects produced IgM Abs against mono-methylated K9 of H31-19 (H31-19K9me. Our further studies revealed that ε-amine mono-methylated lysine could completely inhibit the IgM binding to H31-19K9me, but lysine had no inhibitory effect. In addition, the IgM Abs could bind peptides containing a mono-methylated lysine residue but with totally different sequences. Thus, mono-methylated lysine was the sole epitope for the IgM. Interestingly, SLE patients had much lower levels of this type of IgM. There was no obvious correlation between the IgM levels and disease activity and the decreased IgM was unlikely caused by medical treatments.We also found that the IgM Abs were not polyreactive to dsDNA, ssDNA, lipopolysaccharide (LPS or insulin and they did not exist in umbilical cord serum, implying that they were not natural Abs. The IgM Abs against mono-methylated lysine are present in healthy subjects but are significantly lower in SLE patients, suggesting a distinct origin of production and special physiological functions.

  6. Range optimization for mono- and bi-energetic proton modulated arc therapy with pencil beam scanning

    Science.gov (United States)

    Sanchez-Parcerisa, Daniel; Kirk, Maura; Fager, Marcus; Burgdorf, Brendan; Stowe, Malorie; Solberg, Tim; Carabe, Alejandro

    2016-11-01

    The development of rotational proton therapy plans based on a pencil-beam-scanning (PBS) system has been limited, among several other factors, by the energy-switching time between layers, a system-dependent parameter that ranges between a fraction of a second and several seconds. We are investigating mono- and bi-energetic rotational proton modulated arc therapy (PMAT) solutions that would not be affected by long energy switching times. In this context, a systematic selection of the optimal proton energy for each arc is vital. We present a treatment planning comparison of four different range selection methods, analyzing the dosimetric outcomes of the resulting treatment plans created with the ranges obtained. Given the patient geometry and arc definition (gantry and couch trajectories, snout elevation) our in-house treatment planning system (TPS) FoCa was used to find the maximum, medial and minimum water-equivalent thicknesses (WETs) of the target viewed from all possible field orientations. Optimal ranges were subsequently determined using four methods: (1) by dividing the max/min WET interval into equal steps, (2) by taking the average target midpoints from each field, (3) by taking the average WET of all voxels from all field orientations, and (4) by minimizing the fraction of the target which cannot be reached from any of the available angles. After the range (for mono-energetic plans) or ranges (for bi-energetic plans) were selected, the commercial clinical TPS in use in our institution (Varian Eclipse™) was used to produce the PMAT plans using multifield optimization. Linear energy transfer (LET) distributions of all plans were also calculated using FoCa and compared among the different methods. Mono- and bi-energetic PMAT plans, composed of a single 180° arc, were created for two patient geometries: a C-shaped target located in the mediastinal area of a thoracic tissue-equivalent phantom and a small brain tumor located directly above the brainstem. All

  7. Relação entre intensidade de dor e capacidade funcional em indivíduos obesos com osteoartrite de joelho Relationship between pain intensity and functional capacity of obese individuals with knee osteoarthritis

    Directory of Open Access Journals (Sweden)

    KSS Vasconcelos

    2006-01-01

    Full Text Available CONTEXTUALIZAÇÃO: A osteoartrite (OA de joelho é uma doença crônica que acomete a cartilagem articular, provocando alterações ósseas, dor e rigidez à movimentação. A obesidade é um dos seus principais fatores de risco. As queixas de dificuldades funcionais são freqüentes, especialmente para a locomoção, que se torna mais lenta. Com os crescentes níveis de obesidade no Brasil, torna-se importante compreender como a OA de joelho afeta a capacidade funcional humana, a fim de se elaborar medidas de tratamento e prevenção. OBJETIVO: Analisar a influência da intensidade de dor, gravidade radiográfica, grau de obesidade e duração dos sintomas na capacidade funcional de indivíduos obesos com OA de joelho. MÉTODO: A intensidade de dor foi medida pelo questionário Western Ontario and McMaster Universities Index (WOMAC e durante os testes funcionais. A gravidade radiográfica foi analisada pela classificação Kellgren-Lawrence e o grau de obesidade pelo índice de massa corporal (IMC. Foram realizados quatro testes funcionais de velocidade: marcha usual e rápida, subir e descer escadas. RESULTADOS: A amostra foi constituída de 31 mulheres e 4 homens, com idade média de 51,65 ± 10,72 anos e IMC médio de 41,16 ± 8,37 kg/m². As atividades em escadas estavam associadas a níveis mais intensos de dor. Apenas a intensidade de dor apresentou correlações significativas com os resultados nos testes de velocidade. CONCLUSÃO: A intensidade de dor é um fator que influencia a realização de atividades funcionais em indivíduos obesos com OA de joelho, mas outros estudos são necessários para identificar os fatores determinantes de capacidade funcional nesta população.BACKGROUND: Knee osteoarthritis is a chronic disease that affects joint cartilage, causing bone structure alterations, pain and stiffness during movement. Obesity is one of its principal risk factors. Complaints about functional disability are frequent, especially

  8. O efeito em curto prazo do bypass gástrico sobre pacientes obesos diabéticos Short-term effect of gastric bypass in obese diabetic patients

    Directory of Open Access Journals (Sweden)

    Aluisio Stoll

    2013-02-01

    Full Text Available OBJETIVO: estudar o efeito do bypass gástrico sobre a glicemia e o uso de medicação antidiabética em pacientes obesos portadores de diabetes. MÉTODOS: estudo de coorte retrospectivo com 44 pacientes obesos portadores de DM2, provenientes de 469 pacientes submetidos ao bypass gástrico no período de dezembro de 2001 a março de 2009. Os desfechos primários avaliados foram: glicemia em jejum e a necessidade de medicação antidiabética. RESULTADOS: a população foi composta de dez (22,7% homens e 34 (77,3% mulheres, com média de idade de 45,3 (±8,23 anos e índice de massa corporal de 40,9 (±5,03 kg/m². O tempo médio de evolução do DM2 foi 63,6 (±60,9 meses. Dos 40 pacientes que utilizavam medicação para controle do DM2, 20 (50% tiveram sua medicação suspensa na alta hospitalar e 13 (32,5% até nove meses depois. Em uma paciente não foi possível avaliar o uso de medicação, sendo essa a única exclusão. A insulina foi suspensa nos dez (100% pacientes que a utilizavam, sendo seis (60% na alta hospitalar. Houve redução (POBJECTIVE: To study the effect of gastric bypass on blood glucose levels and the use of antidiabetic medication in obese patients with diabetes. METHODS: We carried out a retrospective cohort study with 44 obese patients with DM2, from 469 patients undergoing gastric bypass from December 2001 to March 2009. The primary endpoints evaluated were fasting glucose and the need for antidiabetic medication. RESULTS: The study population consisted of ten (22.7% men and 34 (77.3% women, with a mean age of 45.3 (±8.23 years and a body mass index of 40.9 (±5.03 kg/m². The average time to progression of DM2 was 63.6 (±60.9 months. Of the 40 patients who used medication to control type 2 diabetes, 20 (50% had their medication discontinued at discharge and 13 (32.5%, until nine months later. In one patient it was not possible to evaluate the use of medication, this being the only exception. Insulin was suspended in

  9. Effects of telmisartan vs olmesartan on metabolic parameters, insulin resistance and adipocytokines in hypertensive obese patients Efectos de telmisartan vs olmesartan sobre parámetros antropométricos, resistencia a la insulina y adipocitoquinas en pacientes hipertensos obesos

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    D. A. de Luis

    2010-04-01

    Full Text Available Background: Angiotensin II regulates the production of adipokines. The objective was to study the effect of treatment with telmisartan versus olmesartan in hypertensiveobese and overweight patients. Subjects: A sample of 65 overweight and obese patients with mild to moderate hypertension was analyzed in a prospective way with a randomized trial. Patients were randomized to telmisartan (80 mg/day or olmesartan (40 mg/day for 3 months. Weight, body mass index, blood pressure, basal glucose, insulin, total cholesterol, LDLcholesterol, HDL-cholesterol, triglycerides, HOMA, QUICKI, leptin and adiponectin were determined at basal time and after 3 months of treatment. Results: Sixty five patients gave informed consent and were enrolled in the study. Patients treated with telmisartan had a significative decrease of glucose 10.53 mg/dl (CI 95%: 2.6-18.5, insulin 2.51 mUI/L (CI 95%: 2.07-7.17 and HOMA 1.08 (CI 95%: 0.39-2.55. Patients treated with olmesartan had a significative decrease of total cholesterol 20.2 mg/dl (CI 95%: 5.8-34.9 and LDL cholesterol 22.6 mg/dl (CI 95%: 9.7-35.6. Only leptin levels have a significant decrease in telmisartan group 7.39 ng/ml (CI 95%: 1.47-13.31. Conclusion: Telmisartan improved blood pressure, glucose, insulin, HOMA and leptin in hypertensive diabetic patients. Olmesartan improved blood pressure and lipid levels.Introducción: La angiotensina II puede regular la producción de adipocitoquinas. El objetivo de nuestro trabajo fue evalaur el efecto sobre parámetros bioquímicos del tratamiento con telmisartan versus olmesartan en pacientes obesos hipertensos. Pacientes: Se analizó una muestra de 65 pacientes con hipertensión moderada severa y obesidad, mediante un ensayo clínico randomizado. Los pacientes fueron randomizados en dos ramas; telmisartan (80 mg/día u olmesartan (40 mg/día durante 3 meses. Se determinaron en el tiempo basal y tras 3 meses los siguientes parámetros; peso, índice de masa corporal, presi

  10. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    Full Text Available FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo Modelo de Avaliação da Homeostase (HOMA-RI: com resistência insulínica (RI n = 39 e sem resistência insulínica (NRI n = 27, e foram submetidos a uma intervenção interdisciplinar ao longo de um ano. A espessura mediointimal da artéria carótida comum (EMIC, e o tecido adiposo visceral e subcutâneo foram determinados por ultrassonografia. A composição corporal, pressão arterial, índice HOMA-RI, perfil lipídico e as concentrações de adipocinas [leptina, adiponectina, e inibidor do ativador do plasminogênio-1 (PAI-1] foram analisados antes e após a terapia. RESULTADOS: Ambos os grupos apresentaram melhoras significativas na composição corporal, estado inflamatório (redução da concentração de leptina e PAI 1; aumento de adiponectina plasmática e redução da EMIC. Apenas o grupo NRI mostrou correlação positiva entre as alterações na gordura visceral (∆Visceral e mudanças na EMIC (∆ EMIC (r = 0,42, p BACKGROUND: The atherosclerotic process at the endothelial level begins in early ages and seems to be associated with obesity and its comorbidities as insulin resistance. OBJECTIVE: The aim of this study was to verify the influence of insulin resistance on inflammatory and subclinical markers of atherosclerosis in obese adolescents. METHODS: Sixty-six post-pubescent obese adolescents were divided in two groups according to homeostasis model assessment of insulin resistance (HOMA-IR measurement: with insulin resistance

  11. Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin- Mono-Resistant Pulmonary Tuberculosis in Lima, Peru

    Science.gov (United States)

    Villegas, Leonela; Huaman, Moises A.; Van der Stuyft, Patrick; Gotuzzo, Eduardo; Seas, Carlos

    2016-01-01

    Background Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes. Methods A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Löwenstein-Jensen (LJ) media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment. Results Of 1292 patients enrolled, 1039 (80%) were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8%) patients and rifampicin mono-resistance was present in 24 (2%) patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR) = 2.10; 95% confidence interval (CI): 1.1–4.1), and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95%CI: 1.9–47.8). Isoniazid mono-resistant patients had a higher risk of poor treatment outcomes including treatment failure (2/85, 2%, p-value<0.01) and death (4/85, 5%, p<0.02). Rifampicin mono-resistant patients had a higher risk of death (2/24, 8%, p<0.01). Conclusion A high prevalence of isoniazid and rifampicin mono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes. PMID:27045684

  12. Influencia de un programa de actividad física en niños y adolescentes obesos: evaluación del estrés fisiológico mediante compuestos en la saliva; protocolo de estudio

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    M. J. Aguilar Cordero

    2013-06-01

    Full Text Available Diferentes estudios1,2 relacionan que el estrés aumenta en los niños y adolescentes con sobrepeso y obesidad, y en consecuencia sus respuestas fisiológicas salivales (Alfa-amilasa salivar AEA, Cortisol, Citoquinas, Leptina, por eso en este estudio queremos relacionar estos dos parámetros para ver su evolución a través de un programa de Actividad Física. Si logramos reducir el sobrepeso u obesidad se debería reducir también estas respuestas fisiológicas y el estrés, por lo que mejoraría el estado de salud general de estos niños y adolescentes. El objetivo general del estudio es conocer la influencia de la actividad física, en niños y adolescentes obesos, en el estrés percibido. Se realizará un estudio observacional, descriptivo, prospectivo y longitudinal. El universo estará constituido por 60 niños y adolescentes con edades comprendidas entre 10 y 18 con sobrepeso/obesidad. La valoración tendrá lugar desde septiembre de 2012 hasta septiembre de 2013. Para la recogida de las muestras de saliva se utilizará el método ELISA³. También se recogerán variables como el IMC, hábitos de vida y alimentación. De entre los resultados esperados están el bajar el sobrepeso y obesidad en los niños mediante el programa de actividad física. Disminuir el estrés fisiológico y normalizar los parámetros salivares.

  13. Influência da distribuição da gordura corporal sobre a prevalência de hipertensão arterial e outros fatores de risco cardiovascular em indivíduos obesos

    Directory of Open Access Journals (Sweden)

    Carneiro Gláucia

    2003-01-01

    Full Text Available OBJETIVOS: Indivíduos obesos são mais predispostos à ocorrência de eventos cardiovasculares que indivíduos com peso normal. Para se avaliar o impacto da obesidade e da distribuição de gordura corporal sobre o risco cardiovascular, avaliamos uma população de indivíduos com sobrepeso ou obesidade. MÉTODOS: Foram feitas medidas do índice de massa corporal (IMC, da relação entre as medidas da cintura e do quadril (RCQ, da pressão arterial sistólica (PAS e diastólica (PAD e dos níveis da glicemia de jejum, colesterol total e triglicérides. RESULTADOS: Altas prevalências de intolerância à glicose ou diabetes (21,8%, hipercolesterolenemia (49,1%, hipertrigliceridemia (21,3% e hipertensão arterial (43,8% foram observadas nesta população. A prevalência de hipertensão aumentou de 23% no grupo com sobrepeso (IMC 25-29,9 kg/m² para 67,1% (p 40kg/m². Também a prevalência de hipertensão aumentou de 35,7% naqueles com RCQ entre 0,73 e 0,88 para 66,6% naqueles com RCQ >0,97 (p 40kg/m² (p<0,05. CONCLUSÃO: A obesidade favorece a ocorrência dos fatores de risco cardiovascular, sendo que a distribuição central da gordura corporal se destaca especialmente como fator importante no desenvolvimento da hipertensão arterial.

  14. Estudio in vivo de la oxidación mitocondrial en pacientes obesos tratados mediante restricción calórica In vivo study of mitochondrial oxidation in obese patients treated by means of calorie restriction

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    M.ª D. Parra

    2004-10-01

    Full Text Available La restricción calórica es la terapia nutricional más frecuente en el tratamiento de la obesidad, cuya eficacia depende de la respuesta oxidativa del organismo para evitar la modificación del peso corporal. En este contexto, el objetivo del presente trabajo fue examinarin vivo la oxidación mitocondrial de voluntarios obesos, antes y después de adelgazar, utilizando el test en aliento con 2-ceto[1-13C]isocaproato. El estudio se realizó en 32 voluntarios de ambos sexos: 16 controles (índice de masa corporal: 19,0-27,0 kg/m², y 16 obesos (índice de masa corporal: 30,0-41,6 kg/m² que siguieron un período de restricción calórica (-500 kcal durante 10 semanas. El test con 2-ceto[1-13C]isocaproato se realizó antes y después del tratamiento, a partir de la ingestión de 1 mg/kg de trazador y 20 mg/kg de L-leucina, disueltos en 200 mL de zumo de naranja. Antes y después de la ingestión (cada 10 minutos durante 2 horas, se tomaron muestras de aliento en las que se midió el enriquecimiento en13C mediante espectrometría de masas de relación isotópica. A partir de estas determinaciones se calculó el porcentaje de trazador oxidado en las mitocondrias (%13C. Los obesos tendieron a oxidar un porcentaje menor de trazador que los controles (25,1 ± 5,5% vs 27,5 ± 4,0% p = 0,175. Tras el período de intervención, la pérdida de peso medio fue -7,8 ± 3% (p The energy restriction is the most common nutritional approach to treat obesity, whose efficiency depends on oxidative response against changes in body weight. In that context, the aim of the present work was to in vivo examine the mitochondrial oxidation of obese volunteers by the 2-keto[1-13C]isocaproate breath test, before and after weight loss. Thirty-two volunteers (men and women participated: 16 controls (body mass index: 19.0-27.0 kg/m², and 16 obese (body mass index: 30.0-41.6 kg/m² who followd a caloric restriction program for 10 weeks (-500 kcal. Before and after dieting, the

  15. Caracterização dos distúrbios de sono, ronco e alterações do sistema estomatognático de obesos candidatos à Cirurgia Bariátrica

    Directory of Open Access Journals (Sweden)

    Roberta Mores

    2017-03-01

    Full Text Available Introdução: Indivíduos obesos apresentam algumas características peculiares das estruturas que podem comprometer as funções do sistema estomatognático. Objetivo: Caracterizar estruturas e funções do sistema estomatognático, distúrbios de sono e ronco em obesos mórbidos candidatos à gastroplastia. Materiais e métodos: amostra constituída por 28 indivíduos, idade entre 22 e 65 anos, candidatos à cirurgia bariátrica. Avaliou-se o sistema estomatognático, aplicou-se Escala de Sonolência de EPWORTH e questionário de Qualidade de Vida de Pittsburgh. Resultados: Apresentara-se alteradas a morfologia (53,7% e postura da língua (32,1%, circunferência de pescoço aumentada (96,4% e Mallampati entre classe III e IV (85,8%. Referente à Escala de Sonolência de EPWORTH, 17,9% apresentaram alterações. Em relação aos aspectos do sono e ronco, 71,5% dos pacientes declararam roncar, 50% referiram falta de ar durante o sono e 75% sentem sonolência diurna. Em relação ao escore global do questionário de Qualidade de Vida de Pittsburgh, 60,7% dos pacientes classificaram o sono como ruim. Os escores do teste de Mallampati associaram-se ao índice de massa corporal e a dificuldade de sono na Escala de EPWORTH. Discussão: A intervenção em pacientes pré ou pós gastroplastia busca intervir nas estruturas e funções do sistema estomatognático, visando melhor correlação entre forma e função que podem contribuir para demais aspectos abordados pela equipe multidisciplinar e que promovam qualidade de vida. Conclusão: Indivíduos obesos mórbidos apresentam morfologia e postura da língua alteradas e circunferência do pescoço aumentada. Referem queixas relativas a dificuldades de sono, principalmente, presença de ronco, descontinuidade do sono noturno e sonolência diurna. ABSTRACT Characteristics of sleep disorders, snoring and disorders of stomatognatic system on obeses candidates for bariatric surgery Introduction: Obese

  16. Adherencia pre y postoperatoria a la dieta mediterránea y su efecto sobre la pérdida de peso y el perfil lipídico en pacientes obesos mórbidos sometidos a gastrectomía vertical como procedimiento bariátrico

    Directory of Open Access Journals (Sweden)

    Jaime Ruiz-Tovar

    Full Text Available Introducción: El cumplimiento de la dieta mediterránea es cada vez menor, incluso en países mediterráneos, a pesar de estar considerada como un ejemplo de dieta saludable. Objetivos: El objetivo principal de este trabajo fue evaluar la adherencia a la dieta mediterránea en pacientes obesos mórbidos antes y después de ser sometidos a una gastrectomía vertical como técnica bariátrica. Así mismo, se analizó también la influencia de la adherencia sobre la pérdida de peso conseguida y sobre la evolución de los factores de riesgo cardiovasculares. Material y métodos: Se realizó un estudio observacional prospectivo de todos los pacientes sometidos a una gastrectomía vertical entre octubre de 2010 y mayo de 2012. Los pacientes rellenaron un test KIDMED (evalúa la adherencia a la dieta mediterránea antes de la operación y 1 año después de la misma. Resultados: Se incluyeron un total de 50 pacientes en el estudio. Antes de la operación, el 30% de los pacientes estudiados presentaban una baja adherencia a la dieta mediterránea, el 64% una adherencia moderada y sólo un 6% una buena adherencia. Al año de la intervención, sólo un 2% de los casos presentaban una baja adherencia, un 58% una adherencia moderada y un 40% una buena adherencia a la dieta mediterránea (p=0,02. Se estableció una correlación inversa entre el aumento de puntuación del test KIDMED (indicador de mayor adherencia a la dieta mediterránea y la pérdida de peso (Spearman -0,357; p=0,008, el descenso en los valores de colesterol total (Spearman -0,442; p=0,003 y de LDL-colesterol (Spearman -0,464; p=0,002. Además, se observó una correlación directa entre el aumento de puntuación del test KIDMED y el incremento en los niveles de HDL-colesterol (Spearman 0,562; p=0,001. Conclusiones: Después de la operación, los pacientes cumplen mejor los patrones de dieta mediterránea. Aquellos pacientes con mejor adherencia a la misma, consiguieron una mayor p

  17. Oxygen uptake of overweight and obese children at different stages of a progressive treadmill test. (Consumo de oxígeno de niños y niñas con sobrepeso y obesos en los diferentes estadios de una prueba progresiva en un tapiz rodante.

    Directory of Open Access Journals (Sweden)

    Colleen Ann Boyle

    2010-01-01

    Full Text Available AbstractIntroduction: Maximal oxygen uptake (VO2 max is associated with cardiovascular and metabolic risks but it is difficult to assess in obese children. The objective of this study was to develop an equation to estimate VO2 (mL/kg/min and to check the % of tests that were maximal according to recommended criteria. Methods: Stress tests were analyzed of 222 subjects (94 male and 128 female with a BMI above the 85 percentile for age and sex, and repeated 4 months later. Mean age was 9.4 + 1.1 years and weighed 52.4 + 13.3 kg. Body fat % (40.5 + 6.2 was determined by DXA (Hologic QDR 4500W. The protocol on the treadmill started with a warm up at 2.5 and 3 mph with a slope of 0% and 2%. The speed was kept at 3 mph for all the stages and the slope was increased 2% every 2 minutes. Statistical analysis (descriptive, t-test and ANOVAS 2x2x2 was done with SPSS 15.0. Results: Only 35% of the tests were maximal. The equation calculates was Y = 2.6x + 22.3 (x = protocol stage. Data pre and post treatment were not statistically different. Discussion: Increments in VO2 were consistent despite subject diversity (sex, % body fat, physical fitness, treatment. Conclusion: To be able to estimate VO2 at the different stages of the test without complex equipment or specialized staff, will facilitate the performance of stress tests on a daily basis.ResumenIntroducción: El consumo máximo de oxígeno (VO2 max está asociado con riesgos cardiovasculares y metabólicos pero resulta difícil valorarlo en niños y niñas obesos. El objetivo de este trabajo fue desarrollar una ecuación para estimar su VO2 (mL/kg/min y comprobar el porcentaje de pruebas máximas según los criterios recomendados. Métodos: Se analizaron las pruebas de esfuerzo de 222 sujetos (94 varones y 128 mujeres con un IMC superior al percentil 85 para su edad y sexo, y las repetidas a los 4 meses. Su edad era 9,4 + 1,1 años y pesaban 52,4 + 13,3 kg. El % de grasa corporal (40,5 + 6,2 se

  18. Seed mediated synthesis of highly mono-dispersed gold nanoparticles in the presence of hydroquinone

    Science.gov (United States)

    Kumar, Dhiraj; Mutreja, Isha; Sykes, Peter

    2016-09-01

    Gold nanoparticles (AuNPs) are being studied for several biomedical applications, including drug delivery, biomedical imaging, contrast agents and tumor targeting. The synthesis of nanoparticles with a narrow size distribution is critical for these applications. We report the synthesis of highly mono-dispersed AuNPs by a seed mediated approach, in the presence of tri-sodium citrate and hydroquinone (HQ). AuNPs with an average size of 18 nm were used for the synthesis of highly mono-dispersed nanocrystals of an average size 40 nm, 60 nm, 80 nm and ˜100 nm; but the protocol is not limited to these sizes. The colloidal gold was subjected to UV-vis absorbance spectroscopy, showing a red shift in lambda max wavelength, peaks at 518.47 nm, 526.37 nm, 535.73 nm, 546.03 nm and 556.50 nm for AuNPs seed (18 nm), 40 nm, 60 nm, 80 nm and ˜100 nm respectively. The analysis was consistent with dynamic light scattering and electron microscopy. Hydrodynamic diameters measured were 17.6 nm, 40.8 nm, 59.8 nm, 74.1 nm, and 91.4 nm (size by dynamic light scattering—volume %); with an average poly dispersity index value of 0.088, suggesting mono-dispersity in the size distribution, which was also confirmed by transmission electron microscopy analysis. The advantage of a seed mediated approach is a multi-step growth of nanoparticle size that enables us to control the number of nanoparticles in the suspension, for size ranging from 24.5 nm to 95.8 nm. In addition, the HQ-based synthesis of colloidal nanocrystals allowed control of the particle size and size distribution by tailoring either the number of seeds, amount of gold precursor or reducing agent (HQ) in the final reaction mixture.

  19. Escitalopram tolerability as mono- versus augmentative therapy in patients with affective disorders: a naturalistic study

    Directory of Open Access Journals (Sweden)

    Dell'Osso B

    2013-02-01

    Full Text Available Bernardo Dell’Osso, Chiara Arici, Cristina Dobrea, Giulia Camuri, Beatrice Benatti, A Carlo AltamuraUniversity of Milan, Department of Psychiatry, Fondazione IRCSS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, ItalyBackground: Escitalopram is a selective serotonin reuptake inhibitor, widely used in the treatment of affective disorders. The purpose of this study was to examine its safety and tolerability, as mono- versus augmentative therapy, in a group of patients with affective disorders.Materials and methods: The sample consisted of 131 patients suffering from different affective disorders, including major depressive disorder, bipolar disorder, and generalized anxiety disorder, who received escitalopram for at least 4 weeks. Data were analyzed on the basis of mono- versus augmentative therapy, as well as age, gender, mean daily dosage, and patterns of combination therapy.Results: Sixty-seven (51.1% patients were treated with monotherapy (mean dose of 11.76 mg/day and 64 (48.9% with augmentative escitalopram (mean dose of 12.81 mg/day. The mean duration of escitalopram treatment was 14 months. The most frequently combined compounds were: other antidepressants (36.5%, mood stabilizers (33.4%, and atypical antipsychotics (30.1%. Side effects were reported in 5.3% of the total sample and the most common were insomnia (2.3%, nausea (2.3%, and dizziness (0.8%. No significant difference, in terms of tolerability, in mono- versus augmentative therapy groups was found. In addition, neither age nor gender was significantly correlated with a greater presence of side effects. Finally, no significant correlation between dosage and side effects was observed.Conclusion: Over a 14-month observation period, escitalopram, either as monotherapy or an augmentative treatment, was found to be well tolerated in a large sample of patients with affective disorders, with an overall low rate of side effects.Keywords: affective disorders, escitalopram

  20. New ruthenium nitrosyl pincer complexes bearing an O2 ligand. Mono-oxygen transfer.

    Science.gov (United States)

    Fogler, Eran; Efremenko, Irena; Gargir, Moti; Leitus, Gregory; Diskin-Posner, Yael; Ben-David, Yehoshoa; Martin, Jan M L; Milstein, David

    2015-03-02

    We report on Ru((II))(μ(2)-O2) nitrosyl pincer complexes that can return to their original Ru(0) state by reaction with mono-oxygen scavengers. Potential intermediates were calculated by density functional theory (DFT) and a mechanism is proposed, revealing a new type of metal-ligand cooperation consisting of activation of the O2 moiety by both the metal center and the NO ligand. Reaction of the Ru(0) nitrosyl complex 1 with O2 quantitatively yielded the crystallographically characterized Ru((II)) (μ(2)-O2) nitrosyl complex 2. Reaction of 2 with the mono-oxygen scavengers phosphines or CO gave the Ru(0) complex 1 and phosphine oxides, or the carbonyl complex 3 (1 trapped by CO) and CO2, respectively. Reaction of 2 with 1 equiv of phosphine at room temperature or -40 °C resulted in immediate formation of half an equivalent of 1 and 1 equiv of phosphine oxide, while half an equivalent of 2 remained unchanged. Overnight reaction at room temperature of 2 with excess CO (≥3 equiv) resulted in 3 and CO2 gas as the only products. Reaction of 1 with 1 equiv of mono-oxygen source (dioxirane) at -78 °C yielded the Ru((II))(μ(2)-O2) complex 2. Similarly, reaction of the Ru(0) dearomatized complex 4 with O2 led to the crystallographicaly characterized Ru((II))(μ(2)-O2) complex 5. Further reaction of 5 with mono-oxygen scavengers (phosphines or CO) led to the Ru(0) complex 4 and phosphine oxides or complex 6 (4 trapped by CO) and CO2. When instead only 1 equiv of 5 was reacted with 1 equiv of phosphine at room temperature, immediate formation of half an equivalent of 4 and 1 equiv of phosphine oxide took place, while half an equivalent of 5 remained unchanged. When 5 reacted with an excess of CO (≥3 equiv), complex 6 and CO2 gas were the only products obtained. DFT studies indicate a new mode of metal-ligand cooperation involving the nitrosyl ligand in the oxygen transfer process.

  1. Reductive cleavage of nitrite to form terminal uranium mono-oxo complexes.

    Science.gov (United States)

    Lewis, Andrew J; Carroll, Patrick J; Schelter, Eric J

    2013-01-09

    Uranium terminal mono-oxo complexes are prepared with a unique activation of nitrite following reductive cleavage of an N-O bond with loss of nitric oxide. The thermodynamic driving force of U═O bond formation differentiates this reactivity from known mechanisms of nitrite reduction, which are typically mediated by proton transfer. Mechanistic details are explored by DFT supporting a simple homolytic cleavage pathway from a κ(1)-ONO bound intermediate. Complexes of the formula U(VI)OX[N(SiMe(3))(2)](3) are formed providing a trigonal bipyramidal framework into which ligands trans to the U═O bond may be installed.

  2. The effect of the polycrystalline furnace in Mono -like growth process

    Institute of Scientific and Technical Information of China (English)

    Li Liu; Zhenzhen Yao; Yan Feng Ning; Xie Min Peng

    2015-01-01

    In this work,we found that the polycrystalline furnace of the thermal field simulation,which has a very important role in this class the growth of monocrystalline silicon.The software is Fluent.Polycrystalline furnace thermal field change process is closely related to the nucleation.we have improved the ration of the grain crystal,and reduce the height of the seed crystal.It is proved that the electrical of the mono like wafer is rather perfect,and the efficiency of the cell is improved greatly.The simulation cal-culation is well agree with the experimental results.

  3. Search for Dark Matter in Mono-Photon Events at 13 TeV with ATLAS

    CERN Document Server

    Ratti, Maria Giulia; The ATLAS collaboration

    2016-01-01

    A search for Dark Matter in events with an energetic photon and large missing transverse momentum with the ATLAS experiment is presented. The analysis is performed on the data collected from proton-proton collisions delivered by the LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 3.2 fb−1. A solid estimation of the amount of mono-photon events that are due to Standard Model processes is the key ingredient for this search. The techniques developed at this aim are presented. Results are interpreted in terms of direct production of Dark Matter particles.

  4. Degradation of a mono sulfonated azo dye by an integrated bio sorption and anaerobic system

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, L. C.; Campos, R.; Pinheiro, H. M.; Lopes, A.; Ferra, M. I.

    2009-07-01

    A simulated textile effluent containing a mono sulphonated azo dye was fed to an anaerobic bioreactor in which a natural adsorbent, spent brewery grains (SBG), was incorporated. SABG is a by-product of the brewing industry and could act as adsorbent as well an electron shuttle (lignin fraction) in the dye degradation mechanism. Furthermore, it can also work as a conditioner for the anaerobic biomass. The influence of the dye (Acid Orange 7, AO7) concentration (60 and 150 mg/L) and the presence of SBG in the performance of upflow anaerobic sludge blanket reactor (UASB) was evaluated. (Author)

  5. Polyelectrolyte Properties in Mono and Multi-Valent Ionic Media: Brushes and Complex Coacervates

    Science.gov (United States)

    Farina, Robert M.

    Materials composed of polyelectrolytes have unique and interesting physical properties resulting primarily from their charged monomer segments. Polyelectrolytes, which exist in many different biological and industrial forms, have also been shown to be highly responsive to external environmental changes. Here, two specific polyelectrolyte systems, brushes and complex coacervates, are discussed in regards to how their properties can be tailored by adjusting the surrounding ionic environment with mono and multi-valent ions. End-tethered polyelectrolyte brushes, which constitute an interesting and substantial portion of polyelectrolyte applications, are well known for their ability to provide excellent lubrication and low friction when coated onto surfaces (e.g. articular cartilage and medical devices), as well as for their ability to stabilize colloidal particles in solution (e.g. paint and cosmetic materials). These properties have been extensively studied with brushes in pure mono-valent ionic media. However, polyelectrolyte brush interactions with multi-valent ions in solution are much less understood, although highly relevant considering mono and multi-valent counterions are present in most applications. Even at very low concentrations of multi-valent ions in solution, dramatic polyelectrolyte brush physical property changes can occur, resulting in collapsed chains which also adhere to one another via multi-valent bridging. Here, the strong polyelectrolyte poly(sodium styrene sulfonate) was studied using the Surface Forces Apparatus (SFA) and electrochemistry in order to investigate brush height and intermolecular interactions between two brushes as a function of multi-valent counterion population inside a brush. Complex coacervates are formed when polyanions and polycations are mixed together in proper conditions of an aqueous solution. This mixing results in a phase separation of a polymer-rich, coacervate phase composed of a chain network held together via

  6. Transient heating and evaporation of moving mono-component liquid fuel droplets

    DEFF Research Database (Denmark)

    Yin, Chungen

    2016-01-01

    This paper presents a complete description of a model for transient heating and evaporation of moving mono-component liquid fuel droplets. The model mainly consists of gas phase heat and mass transfer analysis, liquid phase analysis, and droplet dynamics analysis, which address the interaction...... between the moving droplets and free-stream flow, the flow and heat and mass transfer within the droplets, and the droplet dynamics and size, respectively. For the liquid phase analysis, the droplets are discretized into a number of control volumes along the radial, polar and azimuthal directions, on each...

  7. Simulation study of accelerator based quasi-mono-energetic epithermal neutron beams for BNCT.

    Science.gov (United States)

    Adib, M; Habib, N; Bashter, I I; El-Mesiry, M S; Mansy, M S

    2016-01-01

    Filtered neutron techniques were applied to produce quasi-mono-energetic neutron beams in the energy range of 1.5-7.5 keV at the accelerator port using the generated neutron spectrum from a Li (p, n) Be reaction. A simulation study was performed to characterize the filter components and transmitted beam lines. The feature of the filtered beams is detailed in terms of optimal thickness of the primary and additive components. A computer code named "QMNB-AS" was developed to carry out the required calculations. The filtered neutron beams had high purity and intensity with low contamination from the accompanying thermal, fast neutrons and γ-rays.

  8. Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.

    Science.gov (United States)

    Yuan, Dongjuan; Lan, Dongming; Xin, Ruipu; Yang, Bo; Wang, Yonghua

    2014-06-12

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1), Penicillium camembertii lipase U-150 (PCL), and Aspergillus oryzae lipase (AOL). Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  9. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    Directory of Open Access Journals (Sweden)

    Dongjuan Yuan

    2014-06-01

    Full Text Available Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1 from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1, Penicillium camembertii lipase U-150 (PCL, and Aspergillus oryzae lipase (AOL. Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  10. Simultaneous determination of mono- and disubstituted polyfluoroalkyl phosphates in drinking water by liquid chromatography-electrospray tandem mass spectrometry.

    Science.gov (United States)

    Ding, Huanhuan; Peng, Hui; Yang, Min; Hu, Jianying

    2012-03-02

    A sensitive liquid chromatography-electrospray tandem mass spectrometry method was established for the simultaneous determination of five monosubstituted polyfluoroalkyl phosphates (monoPAPs) and eight disubstituted polyfluoroalkyl phosphates (diPAPs) in drinking water. Complete separation and good retention for 13 polyfluoroalkyls phosphates (PAPs) were achieved with a Waters ACUITY UPLC BEH C8 column using a mixture of methanol/water containing 0.1% NH₄OH as the mobile phases. Extraction of drinking water samples was performed on weak anion exchange (WAX) cartridges, and the recoveries of target compounds were from 65 to 110%. The limits of quantization (LOQs) for 13 analytes were in the range of 0.4-40 ng/L. This method was applied to analyze the PAPs in drinking water samples from three cities in China. Of the 13 PAPs, six PAPs including 6:2 monoPAP (13.0 ng/L), 8:2 monoPAP (3.6 ng/L), 10:1 monoPAP (4.3-70.3 ng/L), 10:2 monoPAP (1.4-5.6 ng/L), 8:2 diPAP (0.10 ng/L), and 10:1 diPAP (0.8-3.8 ng/L) were detected.

  11. [Study on biodegradation of 2,4-DCP by anaerobic sludge acclimated by mixed mono-chlorphenols].

    Science.gov (United States)

    Zhang, Wen; Chen, Ling; Ji, Jun-Ping; Xia, Si-Qing

    2007-06-01

    Purpose of this study was to determine the treatability of 2,4-dichlorophenol (2,4-DCP) by anaerobic granular sludge which was acclimated by mixed mono-chlorphenols (2-CP, 4-MCP). The characteristic of degradation of 2,4-DCP by anaerobic sludge acclimated by mixed mono-chlorphenols was investigated through shake flask study and performance of continuous flow anaerobic bioreactors. The difference of degradation of 2,4-DCP by acclimated and unacclimated sludge was also compared. 2,4-DCP was degraded at 50 h and 180 h respectively for acclimated and unacclimated sludge, which testified that acclimated sludge could more effectively degrade 2,4-DCP. Although the intermediate product 4-MCP was present in both reaction system, 4-MCP could be degraded completely after 400 h in the acclimated sludge but accumulated in the unacclimated sludge. Therefore, acclimation by the mixed mono-chlorphenols (2-CP, 4-MCP) could enhance the ability of para- and meta-dechlorination for anaerobic sludge and increase the treatability of 2,4-DCP. The results of continuous anaerobic sludge-suspended carrier bioreactor (ASSCB) indicate that inoculation of the acclimated sludge by mixed mono-chlorphenols can degrade two mono-chlorphenols simultaneously, shorten the setup period, and increase the efficiency of degrading 2,4-DCP. 2-CP was easily degraded with removal rate of over 80% . While the removal rate of 4-MCP was fluctuating within 30% - 80% with changes of its influent concentration.

  12. Rapid identification of vibrio-cholerae O1 by coaglutination test using mono-specifis antibody

    Directory of Open Access Journals (Sweden)

    Bazargan SA

    1996-07-01

    Full Text Available In our investigation, rabbit hyper-immune serum to V.cholerae ogawa was absorbed with V.cholerae inaba whole-cells and vice versa. Applying ammonium sulphate precipitation method, mono-specific g globulins were purified and concentrated from the absorbed whole serum. These antibodies were fixed on staphylococcus cowan 1 NCTC-8325 whole-cells, using different chemical fixatives. It was observed that maximum fixation of g globulin to protein-A was achieved by 1-propanol 50% at 3 hours, which revealed through single radial immuno-diffusion techniqe. The rectal swab samples were cultured in an enrichment bile-peptons broth. After 5 hours 37°C while agitations, one drop of each sample was mixed with one drop of vibrio-cholerae bivalent mono-specific coagglutination reagent (VBCR. The results were read after 2 to 3 minutes. Finally though statistical analysis sensitivity and specificity of coagglutination test were calculated to be 95.1% and 99.2% respectively, when compared to positive & negative controls and conventional culture methods. Using VBCR, coagglutination test can be therefore considered as a simple, reliable and rapid method to detect V.cholerae O1 in the stool of patients in endemic area and less equipped laboratories

  13. Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

    Directory of Open Access Journals (Sweden)

    Wen Zhu

    2013-12-01

    Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

  14. Evaluation of mono or mixed cultures of lactic acid bacteria in type II sourdough system.

    Science.gov (United States)

    Ekinci, Raci; Şimşek, Ömer; Küçükçuban, Ayca; Nas, Sebahattin

    2016-01-01

    The aim of this study was to evaluate the use of mono and mixed lactic acid bacteria (LAB) cultures to determine suitable LAB combinations for a type II sourdough system. In this context, previously isolated sourdough LAB strains with antimicrobial activity, which included Lactobacillus plantarum PFC22, Lactobacillus brevis PFC31, Pediococcus acidilactici PFC38, and Lactobacillus sanfranciscensis PFC80, were used as mono or mixed culture combinations in a fermentation system to produce type II sourdough, and subsequently in bread dough production. Compared to the monoculture fermentation of dough, the use of mixed cultures shortened the adaptation period by half. In addition, the use of mixed cultures ensured higher microbial viability, and enhanced the fruity flavor during bread dough production. It was determined that the combination of L. plantarum PFC22 + P. acidilactici PFC38 + L. sanfranciscensis PFC80 is a promising culture mixture that can be used in the production of type II sourdough systems, and that may also contribute to an increase in metabolic activity during bread production process.

  15. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    KAUST Repository

    Ghoneim, Mohamed T.

    2015-12-11

    In today’s digital world, complementary metal oxide semiconductor (CMOS) technology enabled scaling of bulk mono-crystalline silicon (100) based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm) mono-crystalline (100) silicon (detached from bulk substrate) by utilizing deterministic pattern of porous network of vertical “through silicon” micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs) with high-κ/metal gate stacks.

  16. From toxins to mammalian enzymes: the diversity of mono-ADP-ribosylation.

    Science.gov (United States)

    Grimaldi, Giovanna; Corda, Daniela; Catara, Giuliana

    2015-01-01

    The ADP-ribosylation of proteins is a phylogenetically ancient mechanism that involves the transfer of ADP-ribose from nicotinamide adenine dinucleotide (NAD⁺) to specific amino acids of target proteins post-translationally. In the first part of this review, we briefly describe ADP-ribosylation as the mechanism of action of toxins, while giving particular emphasis to a non-conventional ADP-ribosylation reaction that is mediated by the fungal toxin brefeldin A (BFA). This modification results in the loss of the membrane fission activity of the C-terminal binding protein (CtBP)1/ BFA-ADP-ribosylated substrate (BARS), thus blocking progression of cells into mitosis, with important implications for the design of new anticancer drugs. In addition, we summarize the most recent findings on mammalian, intracellular mono-ADP-ribosyl transferase enzymes, underlining the emerging functional roles in which they are involved, including immune responses, transcriptional regulation, stress responses, cell survival. The observation that several mono-ADP-ribosyl transferases, such as PARP-10, PARP-12, PARP-13, are involved in a range of physiological processes points at the multifunctional feature of these proteins.

  17. Mono-top Signature from Supersymmetric $t \\bar t H$ Channel

    CERN Document Server

    Gonçalves, Dorival; Takeuchi, Michihisa

    2016-01-01

    We point out that a distinctive mono-top signature is present in Natural SUSY scenarios when a scalar top-quark and higgsinos are almost mass degenerate. This signature originates from a supersymmetric counter part of the $t \\bar t H$ process, i.e. $pp \\to \\tilde t t \\tilde h$. Unlike mono-jet signatures exploiting initial state radiation, this channel can be regarded as a smoking gun signature of a light stop and higgsinos, allowing a direct probe of the stop and neutralino sectors. The production rate of this channel largely depends on the up-type higgsino components in the neutralinos while the stop sector is sensitive to angular distributions of top-quark's decay products. We develop an optimal search strategy to capture the supersymmetric $t \\bar t H$ process and find that a high luminosity LHC can probe the stop and higgsino sectors with $m_{\\tilde t_1} \\lesssim 380$ GeV and $m_{\\tilde t_1} - m_{\\tilde \\chi_1^0} \\lesssim m_W$. Additionally, we propose a kinematic variable with which one can measure the ...

  18. TRUST IN MONO-ETHNIC AND MIXED-ETHNIC ASSOCIATIONS IN PENANG

    Directory of Open Access Journals (Sweden)

    James K. Campbell

    2007-01-01

    Full Text Available Investigation into trust has become a topical issue in current socialscience research. This is, in large part, a result of a perception that trust in institutions has declined markedly in the past two decades. This paper investigates trust in some of Penang’s civil associations as a way of measuring the health of social capital in Penang. It focuses on issues of trust and diversity since both are critical issues in Malaysian society in general and civil associations in particular. We began our analysis expecting higher forms of trust among members in the mono-ethnic associations, based on the power of bonding. However, findings from this study tend to suggest that rather than leading to lesser trust and infectiveness, involvement in mixed-ethnic associations have in fact generated higher trust among their members. These findings reveal an interesting corrective to more pessimistic view on the relationshipbetween trust and diversity. Data from this study also provide important insight into how bridging between different people in associations marked by diversity can accentuate trust over and above the levels found in associations were bonding between like types is the dominant characteristic. The data also indicate that for both, mono-ethnic and mixed-ethnic associations, it is the extent of members’ involvements in their associations that form trust and not vice versa.

  19. Interactions of squaric acid with DABCO mono-betaine: Structural, spectroscopic and calculation studies

    Science.gov (United States)

    Barczyński, P.; Dega-Szafran, Z.; Katrusiak, A.; Szafran, M.

    2012-04-01

    The 1:1 complex of squaric acid (3,4-dihydroxy-3-cyclobutene-1,2-dion) with DABCO mono-betaine (1-carboxymethyl-1,4-diazabicyclo[2.2.2]octane inner salt), 1, has been characterized by single-crystal X-ray analysis, FTIR and NMR spectroscopies and by DFT calculations. The crystal of 1 is triclinic, space group P1¯. Short COOH⋯O and Nsbnd H⋯O hydrogen bonds of 2.445(2) and 2.582(2) Å, respectively, link the diprotonated DABCO mono-betaine dications and squarate dianions into chain. The structure is additionally stabilized by the N+⋯O electrostatic interactions and weak Csbnd H⋯O hydrogen bonds. The FTIR spectrum shows two broad absorptions in the 3000-2000 cm-1 region assigned to the νNsbnd H⋯O vibration and in the 1900-500 cm-1 region attributed to the ν(OHO) and γ(OHO) vibrations of the short hydrogen bonds.

  20. Propellant Grade Hydrazine in Mono/Bi-propellant Thrusters: Preparation and Performance Evaluation

    Directory of Open Access Journals (Sweden)

    S. Krishnamachary

    2015-03-01

    Full Text Available Propellant grade hydrazine was prepared with 64 per cent yield and 95.5 per cent purity. Purity of the propellant grade hydrazine was determined using wet chemical, gas chromatographic (GC and eudiometric methods. It was observed that the compositions containing blends of hydrazine-methyl alcohol-ammonium nitrate and hydrazine-methyl alcohol-ammonium perchlorate were not found to be frozen even after cooling to -65 °C for 30 minutes. Mono and bi-propellant thrusters were designed and developed to demonstrate the performance of prepared propellant grade hydrazine as a promising rocket fuel. Five static tests with 22 N thruster and one static test with 1 N thruster were performed successfully in mono-propellant mode. The hurdles of chamber pressure oscillations were overcome by compact packing of the catalyst. The desired decomposition and chamber pressure were achieved. One static test was performed successfully with 60 N bi-propellant thruster. The desired chamber pressure and thrust were achieved. The combustion was smooth and C* achieved was higher than that of UH-25, N2O4 combination. The performance of prepared propellant grade hydrazine shows it as a promising rocket fuels.Defence Science Journal, Vol. 65, No. 1, January 2015, pp.31-38, DOI:http://dx.doi.org/10.14429/dsj.65.7986

  1. Mono-dispersed cross-linked polystyrene micro-spheres prepared by seed swelling polymerization method

    Institute of Scientific and Technical Information of China (English)

    Dongsha WANG; Yanjun LIU

    2008-01-01

    A two-step swelling procedure was adopted to synthesize mono-dispersed and highly cross-linked poly (St-divinylbenzene) particles with PSt micro-spheres (1.80 μmin diameter). The PSt micro-spheres were prepared by a dispersion polymerization method and used as seeds. The effects of monomer concentration, ratio of ethanol to water, swelling reagents, crosslinking reagents, swelling temper-ature and agitation speed on particle size were investigated in detail. The morphologies and size distributions of these micro-spheres were examined by SEM and particle size analysis (PSA). The Tg of the micro-spheres was measured by DSC. The results indicate that the particles (6.20 μm in diameter) exhibit excellent mono dispersed property and high crosslinking degree when the concentration of the swelling reagent was 25%, the concentration of the cross-linking reagents was 23%, the swelling temperature was 30℃ and the stirring speed was 150 r/min.

  2. Roseomonas aceris sp. nov. isolated from a mono maple tree in the Shirakami Mountains in Japan.

    Science.gov (United States)

    Tonouchi, Akio; Tazawa, Daisuke

    2014-01-01

    A novel bacterial strain belonging to the genus Roseomonas was isolated from the trunk surface of a mono maple (Acer mono) tree growing in the Shirakami Mountains. The strain, designated R-1(T), was Gram-negative, non-motile, and oval-rod, and formed reddish colonies on agar plates, as has previously been described for Roseomonas species. Although motility was not observed, cells were peritrichously flagellated. Strain R-1(T) preferred organic acids over carbohydrates as growth substrates. The major cellular fatty acid was C₁₈:₁ ω7c (48.79%). Ubiquinone-10 was the major respiratory quinone. Strain R-1(T) demonstrated the highest 16S rRNA gene sequence similarity with Roseomonas pecuniae N75(T) (96.9%). Phylogenetic analysis based on 16S rRNA gene sequences confirmed that strain R-1(T) was a member of the genus Roseomonas and formed a cluster with R. pecuniae N75(T). DNA-DNA hybridization between strain R-1(T) and R. pecuniae N75(T) yielded 21.7% relatedness. On the basis of its phenotypic, phylogenetic, and chemotaxonomic char-acteristics, strain R-1(T) represents a novel species within the genus Roseomonas, for which the name Roseomonas aceris sp. nov. has been proposed. The type strain is R-1(T) (NBRC 109410(T) = DSM 26554 (T)).

  3. Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome

    Directory of Open Access Journals (Sweden)

    Byun Hyang-Min

    2012-02-01

    Full Text Available Abstract Background Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to affect genome instability. Methods we examined the polymorphic inserted AluYa5, evolutionary young Alu, in the progesterone receptor gene to determine the effects of Alu insertion on molecular environment. We used mono-allelic inserted cell lines which carry both Alu-present and Alu-absent alleles. To determine the epigenetic change and gene expression, we performed restriction enzyme digestion, Pyrosequencing, and Chromatin Immunoprecipitation. Results We observed that the polymorphic insertion of evolutionally young Alu causes increasing levels of DNA methylation in the surrounding genomic area and generates inactive histone tail modifications. Consequently the Alu insertion deleteriously inactivates the neighboring gene expression. Conclusion The mono-allelic Alu insertion cell line clearly showed that polymorphic inserted repetitive elements cause the inactivation of neighboring gene expression, bringing aberrant epigenetic changes.

  4. Enhanced cooling in mono-crystalline ultra-thin silicon by embedded micro-air channels

    Science.gov (United States)

    Ghoneim, Mohamed T.; Fahad, Hossain M.; Hussain, Aftab M.; Rojas, Jhonathan P.; Torres Sevilla, Galo A.; Alfaraj, Nasir; Lizardo, Ernesto B.; Hussain, Muhammad M.

    2015-12-01

    In today's digital world, complementary metal oxide semiconductor (CMOS) technology enabled scaling of bulk mono-crystalline silicon (100) based electronics has resulted in their higher performance but with increased dynamic and off-state power consumption. Such trade-off has caused excessive heat generation which eventually drains the charge of battery in portable devices. The traditional solution utilizing off-chip fans and heat sinks used for heat management make the whole system bulky and less mobile. Here we show, an enhanced cooling phenomenon in ultra-thin (>10 μm) mono-crystalline (100) silicon (detached from bulk substrate) by utilizing deterministic pattern of porous network of vertical "through silicon" micro-air channels that offer remarkable heat and weight management for ultra-mobile electronics, in a cost effective way with 20× reduction in substrate weight and a 12% lower maximum temperature at sustained loads. We also show the effectiveness of this event in functional MOS field effect transistors (MOSFETs) with high-κ/metal gate stacks.

  5. Two coarse pyroclastic flow deposits, northern Mono-Inyo Craters, CA

    Science.gov (United States)

    Dennen, R. L.; Bursik, M. I.; Stokes, P. J.; Lagamba, M.; Fontanella, N.; Hintz, A. R.; Jayko, A. S.

    2010-12-01

    The ~1350 A.D., rhyolitic North Mono eruption, Mono-Inyo Craters, CA, included the extrusion and destruction of Panum Dome and associated clastic deposits. Overlying the tephras of the North Mono sequence, the Panum deposits include a block-and-ash flow (BAF) deposit, covering ~3.5 km2. Blocks within the deposit are typically lithic rhyolite and banded gray micro-vesicular glass, showing white, almost powdery marks ranging from circular to linear in shape. These marks are interpreted as friction marks resulting from collisions between clasts. The deposit also contains bread-crusted obsidians with pressed-in clasts as well as reticulite with a bread-crusted surface texture. Near the centerline of the deposit is a ridge-topping train of jigsaw fractured blocks, often with reddish-orange alteration. One house sized jigsaw block sits upstream of a long, thinning pile of reddish orange debris; this “flow shadow” indicates that the block remained relatively stationary while the block and ash flow continued to propagate around it. The bread-crusted reticulite is most common at proximal localities. It is proposed that the dome destruction included a debris avalanche emplacing the train of jigsaw fractured blocks and creating a topographic high, the block-and-ash flow (the farthest reaching deposit from this event) which flowed around the debris avalanche deposits, and a final “lateral expansion” of a magma foam, creating the reticulite seen concentrated at proximal locations. Another coarse pyroclastic flow (here termed the “lower blast deposit”) underlies the North Mono tephra. It is more obsidian rich and finer grained than the Panum BAF. The lower blast deposit may have originated from Pumice Pit vent, which is now capped with an older dome ~0.5 km southeast of Panum. The lower blast deposit extends farther from the Panum vent than does the Panum BAF deposit, and apparently was mistaken for the Panum BAF deposit by previous workers. Hence the run

  6. Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles.

    Science.gov (United States)

    Craig, Zelieann R; Leslie, Traci C; Hatfield, Kimberly P; Gupta, Rupesh K; Flaws, Jodi A

    2010-12-01

    Methoxychlor (MXC) is an organochlorine pesticide that reduces fertility in female rodents by decreasing antral follicle numbers and increasing follicular death. MXC is metabolized in the body to mono-hydroxy MXC (mono-OH). Little is known about the effects of mono-OH on the ovary. Thus, this work tested the hypothesis that mono-OH exposure decreases production of 17β-estradiol (E₂) by cultured mouse antral follicles. Antral follicles were isolated from CD-1 mice (age 35-39 days) and exposed to dimethylsulfoxide (DMSO), or mono-OH (0.1-10 μg/mL) for 96 h. Media and follicles were collected for analysis of sex steroid levels and mRNA expression, respectively. Mono-OH treatment (10 μg/mL) decreased E(2) (DMSO: 3009.72±744.99 ng/mL; mono-OH 0.1 μg/mL: 1679.66±461.99 ng/mL; 1 μg/mL: 1752.72±532.41 ng/mL; 10 μg/mL: 45.89±33.83 ng/mL), testosterone (DMSO: 15.43±2.86 ng/mL; mono-OH 0.1μg/mL: 17.17±4.71 ng/mL; 1 μg/mL: 13.64±3.53 ng/mL; 10 μg/mL: 1.29±0.23 ng/mL), androstenedione (DMSO: 1.92±0.34 ng/mL; mono-OH 0.1 μg/mL: 1.49±0.43ng/mL; 1 μg/mL: 0.64±0.31 ng/mL; 10 μg/mL: 0.12±0.06 ng/mL) and progesterone (DMSO: 24.11±4.21 ng/mL; mono-OH 0.1μg/mL: 26.77±4.41 ng/mL; 1 μg/mL: 20.90±3.75 ng/mL; 10 μg/mL: 9.44±2.97 ng/mL) levels. Mono-OH did not alter expression of Star, Hsd3b1, Hsd17b1 and Cyp1b1, but it did reduce levels of Cyp11a1, Cyp17a1 and Cyp19a1 mRNA. Collectively, these data suggest that mono-OH significantly decreases levels of key sex steroid hormones and the expression of enzymes required for steroidogenesis.

  7. Missing particle associated with two bottom quarks at the LHC: Mono-$b$ versus 2$b$ with razor variables

    CERN Document Server

    Chen, Ning; Li, Jinmian

    2016-01-01

    The extended Higgs sector such as by a second Higgs doublet of type-II provides portals to dark sector which contains missing particles at the LHC, e.g., dark matter (DM) particle. In this paper, working in the simplified model and taking into consideration the vital wide width effect of the mediator, we analyze the characteristic signatures of mono-$b$+MET and 2$b$+MET at the LHC. The latter signature was believed to be ineffective, but we found that, with the aid of razor shape analysis, it should be as important as the mono-$b$ signature. In the region of relatively low mediator mass (below a few hundred GeV), the 2$b$-tagged razor analysis has comparable sensitivity with the mono-$b$ search when the systematic uncertainty is at percent level; it is even better for mediator lighter than $\\sim 200$ GeV.

  8. Benchmarking of the mono-energetic transport coefficients-results from the International Collaboration on Neoclassical Transport in Stellarators (ICNTS)

    Energy Technology Data Exchange (ETDEWEB)

    Beidler, C. D. [Max-Planck-Institute for Plasmaphysik, EURATOM-Association, Greifswald, Germany; Allmaier, K. [Insitut fur Theoretische Physik, Association EURATOM, Graz, Austria; Isaev, Maxim Yu [Kurchatov Institute, Moscow, Russia; Kasilov, K. [Insitute of Plasma Physics, NSC-KhIPT, Kharkov, Ukraine; Kernbichler, W. [Insitut fur Theoretische Physik, Association EURATOM, Graz, Austria; Leitold, G. [Insitut fur Theoretische Physik, Association EURATOM, Graz, Austria; Maassberg, H. [Max-Planck-Institute for Plasmaphysik, EURATOM-Association, Greifswald, Germany; Mikkelsen, D. R. [Princeton Plasma Physics Laboratory (PPPL); Murakami, Masanori [ORNL; Schmidt, M. [Max-Planck-Institute for Plasmaphysik, EURATOM-Association, Greifswald, Germany; Spong, Donald A [ORNL; Tribaidos, V. [Universidad Carlos III, Madrid, Spain; Wakasa, A. [Kyoto University, Kyoto, Japan

    2011-01-01

    Numerical results for the three mono-energetic transport coefficients required for a complete neoclassical description of stellarator plasmas have been benchmarked within an international collaboration. These transport coefficients are flux-surface-averaged moments of solutions to the linearized drift kinetic equation which have been determined using field-line-integration techniques, Monte Carlo simulations, a variational method employing Fourier-Legendre test functions and a finite-difference scheme. The benchmarking has been successfully carried out for past, present and future devices which represent different optimization strategies within the extensive configuration space available to stellarators. A qualitative comparison of the results with theoretical expectations for simple model fields is provided. The behaviour of the results for the mono-energetic radial and parallel transport coefficients can be largely understood from such theoretical considerations but the mono-energetic bootstrap current coefficient exhibits characteristics which have not been predicted.

  9. Prediction of gas chromatographic retention times of polychlorinated biphenyls by mono-dimensional molecular descriptors and multivariate techniques

    Energy Technology Data Exchange (ETDEWEB)

    Mecozzi, M.; Amici, M. [Istituto Centrale per la Ricerca Scientifica e Technological Applicata al Mare, Rome (Italy); Acquistucci, R. [Istituto Nazionale per la Nutrizione e gli Alimenti, Rome (Italy)

    2003-07-01

    We report a procedure for describing the gas chromatographic retention time of polychlorinated biphenyls (PCBs) as a function of simple mono-dimensional molecular descriptors such as the number and position of chlorine atoms on the aromatic rings. The mathematical relationships between relative retention time (RRT) of all 209 possible congeners of PCBs and the mono-dimensional molecular descriptors (MDDs) were obtained by the multivariate techniques principal component regression (PCR) and partial least squares (PLS) used as modelling tools. The good agreement found between experimental and predicted retention times of PCBs shows that a well established mathematical model relating retention time to specific mono-dimensional molecular descriptors can be a useful tool to enhance identification of these pollutants in real samples. (orig.)

  10. Abu al-Layth al-Libi

    Science.gov (United States)

    2015-02-01

    He has described at length the various methods to which the prisoners were subjected, including sleep depravation, nudity and the use of electrodes...suspects of the Riyadh bombing acknowledge their involvement on television , he was under the impression that they too had been subjugated to this... sleeping , al-Libi, al-Zawi and `Abd al-Karim managed to escape by jumping from the six-meter-tall wall of al-Ruways.38 Their breakout led to a

  11. Grosor de la íntima-media de la arteria carótida en adolescentes obesos y su relación con el síndrome metabólico Intima-media thickness in obese adolescents and their relation with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    C. Torrejón

    2012-02-01

    Full Text Available Introducción: Los adolescentes obesos presentan mayor riesgo cardiovascular (RCV. La medición del grosor de la intima-media (GIM arterial detecta tempranamente el compromiso vascular. Objetivo: Evaluar si los adolescentes obesos tienen mayor compromiso vascular medido por GIM que los adolescentes no obesos, y si este es mayor en aquellos con síndrome metabólico (SM. Metodología: Grupo estudio (GE, niños obesos, IMC/edad > p95, con y sin SM y grupo control, IMC/edad p10-85, sin patología nutricional ni endocrina. Se midieron concentraciones séricas de lípidos, prueba tolerancia oral a glucosa con insulinemia y ecografía de arteria carótida. Para evaluar diferencia entre grupos se utilizaron pruebas estadísticas paramétricas y no paramétricas. Resultados: Se evaluaron 45 adolescentes obesos (20 mujeres, 19 con SM, edad 13 (9-16 años y 18 controles (14 mujeres, edad 13 (11-16 años. GIM del bulbo carotideo y de la arteria carótida interna (ACI fueron significativamente mayores en GE que grupo control (0,54 vs 0,34; 0,34 vs 0,25, p Introduction: Obese adolescents have higher cardiovascular risk (CVR. Intima-media thickness (IMT detects early arterial vascular compromise. Objective: To evaluate whether obese adolescents have higher vascular compromise measured by IMT than nonobese adolescents, and if this is greater in those with metabolic syndrome (MS. Method: The study group (SG, obese children (BMI/age > p95, with and without MS and control group (CG, non-obese (BMI/age p10-85 and non nutritional or endocrine disease. We measured serum lipids, oral glucose tolerance test with insulin and carotid artery ultrasound. To evaluate the differences between test groups we used parametric and nonparametric statistics. Results: We evaluated 45 obese adolescents (20 women, 19 with MS, age 13 (9-16 years and 18 controls (14 women, aged 13 (11-16 years. IMT of carotid bulb and internal carotid artery (ICA were significantly higher in SG than CG

  12. Long-term thermophilic mono-digestion of rendering wastes and co-digestion with potato pulp

    Energy Technology Data Exchange (ETDEWEB)

    Bayr, S., E-mail: suvi.bayr@jyu.fi; Ojanperä, M.; Kaparaju, P.; Rintala, J.

    2014-10-15

    Highlights: • Rendering wastes’ mono-digestion and co-digestion with potato pulp were studied. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was unstable in mono-digestion. • Free NH{sub 3} inhibited mono-digestion of rendering wastes. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was stable in co-digestion. • Co-digestion increased methane yield somewhat compared to mono-digestion. - Abstract: In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55 °C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion intermediate products viz., volatile fatty acids (VFAs), long chain fatty acids (LCFAs) and ammonia nitrogen (NH{sub 4}-N and/or free NH{sub 3}) can cause process imbalance during the digestion. Mono-digestion of rendering wastes at an organic loading rate (OLR) of 1.5 kg volatile solids (VS)/m{sup 3} d and hydraulic retention time (HRT) of 50 d was unstable and resulted in methane yields of 450 dm{sup 3}/kg VS{sub fed}. On the other hand, co-digestion of rendering wastes with potato pulp (60% wet weight, WW) at the same OLR and HRT improved the process stability and increased methane yields (500–680 dm{sup 3}/kg VS{sub fed}). Thus, it can be concluded that co-digestion of rendering wastes with potato pulp could improve the process stability and methane yields from these difficult to treat industrial waste materials.

  13. Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome as compared to germ-free mice

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper

    of colonizing bacteria. In this study the effect of the Lactobacillus acidophilus NCFM strain was investigated by comparing the metabolome of mono-colonized and germ-free mice in several compartments. By liquid-chromatography coupled to mass spectrometry, we were able to show that the metabolome differed...... between the mono-colonized and germ-free mice, not only in ileum, caecum and colon, but also in plasma and liver. These observations suggest that L. acidophilus NCFM highly influence the metabolism in multiple compartments, underlying that the gut microbiota metabolism affects the host systemic metabolism....

  14. Synthesis of Some New Mono- and Bis-Polycyclic Aromatic Spiro and Bis-Nonspiro-β-Lactams

    Directory of Open Access Journals (Sweden)

    Edris Ebrahimi

    2010-01-01

    Full Text Available Some new mono-and bis-polycyclic aromatic spiro-β-lactams and bis-non spiro-polycyclic aromatic β-lactams have been synthesized from imines derived from anthracene-9-carbaldehyde, 2-naphtaldehyde and a ketene derived from 9H-xanthene-9-carboxylic acid and phenoxyacetic acid by a [2+2] cycloaddition reaction. The cycloadducts were characterized by spectral data, including 1H-NMR, 13C-NMR, IR and elemental analyses. The configurations of some of these mono-spiro-β-lactams were established by X-ray crystal analysis.

  15. A load-displacement based approach to assess the bearing capacity and deformations of mono-bucket foundations

    DEFF Research Database (Denmark)

    Vahdatirad, Mohammadjavad; Diaz, Alberto Troya; Nielsen, Søren

    2016-01-01

    It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load–displacemen......It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load...

  16. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor.

    Science.gov (United States)

    Craig, Zelieann R; Hannon, Patrick R; Flaws, Jodi A

    2013-11-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P4) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P4, androstenedione (A), testosterone (T), estrone (E1), and 17β-estradiol (E2) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E2. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P4, A, T, and E1 that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival.

  17. Rabdomiólise em paciente obeso mórbido submetido a gastroplastia redutora e durante revascularização de membro superior em paciente pediátrico: relato de casos

    Directory of Open Access Journals (Sweden)

    Abrão Maria Angélica

    2006-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A rabdomiólise é uma síndrome que decorre da lesão ao músculo esquelético. Sua etiologia é ampla, trazendo um interesse particular, quando se manifesta como complicação intra ou pós-anestésica. O objetivo desse relato foi mostrar dois casos de rabdomiólise ocorridos no pós-operatório de intervenções cirúrgicas de longa duração, em pacientes com obesidade mórbida e lesão traumática, enfatizando a sua relação com a anestesia. RELATO DOS CASOS: O primeiro caso é de um paciente com 39 anos, obeso mórbido, IMC 62, submetido a gastroplastia redutora por laparotomia, sob anestesia geral. Apresentou, no pós-operatório, fraqueza muscular nos membros superiores e inferiores e alterações da sensibilidade. Evoluiu com dor muscular e urina avermelhada. O aumento dos níveis plasmáticos da enzima creatinocinase (CK confirmou o diagnóstico de rabdomiólise. Tratado com hidratação forçada e diurético, não evoluiu com insuficiência renal, porém teve alta com seqüela muscular e neurológica. O segundo caso apresenta uma criança de sete anos, vítima de acidente com porta de vidro, operada de urgência para revascularização do membro superior esquerdo. Apresentou mudança da coloração da urina, que se tornou avermelhada, durante a anestesia. Foram administrados bicarbonato de sódio e manitol por via venosa, com os objetivos de alcalinizar a urina e aumentar o débito urinário. Enviado ao CTI, onde foi confirmada a hipótese de rabdomiólise, pelo aumento da enzima CK e pela mioglobinúria. Obteve alta no 10º dia de internação, sem seqüelas. CONCLUSÕES: Os casos apresentados mostraram os fatores de risco da rabdomiólise e sua relação com a anestesia e a cirurgia. O diagnóstico precoce é importante, no sentido de um tratamento rápido e agressivo, a fim de se evitarem complicações mais graves.

  18. Variaciones en el estado nutricional, presión arterial y capacidad cardiorrespiratoria de obesos candidatos a cirugía bariátrica: beneficios del ejercicio físico con apoyo multidisciplinar

    Directory of Open Access Journals (Sweden)

    Pedro Delgado Floody

    Full Text Available Introducción: la obesidad mórbida disminuye considerablemente la esperanza y la calidad de vida. Objetivo: el objetivo del estudio fue determinar los efectos del ejercicio físico con apoyo multidisciplinar sobre el estado nutricional, la capacidad cardiorrespiratoria y la presión arterial de obesos mórbidos candidatos a cirugía a bariátrica. Material y métodos: doce mujeres y un hombre entre 18 y 60 años candidatos a cirugía bariátrica, 10 con obesidad mórbida y 3 con obesidad y comorbilidades, fueron sometidos a un programa de ejercicio físico con educación nutricional y apoyo psicológico durante 5 meses. Peso corporal, índice de masa corporal (IMC, contorno de cintura (CC, capacidad cardiorrespiratoria, presión arterial sistólica y diastólica fueron evaluados antes y posterior a la intervención. Resultados: el promedio de edad de los participantes de la investigación fue de 49,92 años, el de altura fue 1,62 m. Todas las variables de estudio mejoraron significativamente (p < 0,05: peso (p = 0,000, IMC (p = 0,000, CC (p = 0,005, capacidad cardiorrespiratoria (p = 0,009, presión sistólica (p = 0,006 y presión arterial diastólica (p = 0,010. La capacidad cardiorrespiratoria aumentó un 9,17%, la presión arterial diastólica y sistólica disminuyeron 5,16% y 7,68% respectivamente. El IMC disminuyó un 8,39% y el CC un 6,63%. Conclusiones: el programa mejoró los niveles de presión arterial sistólica y diastólica y la capacidad cardiorrespiratoria, esto se vio complementado por la pérdida de peso significativa en los participantes de esta investigación. El ejercicio físico con apoyo multidisciplinar demuestra beneficios para el tratamiento preoperatorio produciendo adaptaciones favorables en los factores de riesgo cardiovascular.

  19. Organic osmolytes in aerobic bacteria from Mono Lake, an alkaline, moderately hypersaline environment

    Energy Technology Data Exchange (ETDEWEB)

    Ciulla, R.A.; Roberts, M.F. [Boston College, Chestnut Hill, MA (United States); Diaz, M.R.; Taylor, B.F. [Univ. of Miami, FL (United States)

    1997-01-01

    The identity and concentrations of intracellular organic solutes were determined by nuclear magnetic resonance spectroscopy for two strains of aerobic, gram-negative bacteria isolated from Mono Lake, California, an alkaline, moderately hypersaline lake. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) was the major endogenous solute in both organisms. Concentrations of ectoine varied with external NaCl levels in strain ML-D but not in strain ML-G, where the level was high but invariant from 1.5 to 3.0 M NaCl. Hydroxyectoine also occurred in strain ML-D, especially at elevated NaCl concentrations (2.5 and 3.0 M), but at levels lower than those of ectoine. Exogenous organic solutes that might occur in Mono Lake were examined for their effects on the de novo synthesis of ectoine. Dimethylsulfoniopropionate (DMSP) (0.1 or 1 mM) did not significantly lower ectoine levels in either isolate, and only strain ML-G showed any capacity for DMSP accumulation. With nitrogen limitation, however, DMSP (0.1 mM) substituted for ectoine in strain ML-G showed any capacity for DMSP accumulation. With nitrogen limitation, however, DMSP (0.1 mM) substituted for ectoine in strain ML-G and became the main organic solute. Glycine betaine (GB) was more effective than DMSP in affecting ectoine levels, principally in strain ML-D. Strain ML-D accumulated GB to 50 or 67% of its organic solute pool at 2.5 M NaCl, at an external level of 0.1 or 1 mM GB, respectively. Strain ML-D also accumulated arsenobetaine. The methylated zwitterionic compounds, probably metabolic products of phytoplankton (DMSP and GB) or brine shrimps (arsenobetaine) in Mono Lake, may function as osmolytes for indigenous bacteria when present at high concentrations or under conditions of nitrogen limitation or salt stress. 33 refs., 5 figs., 2 tabs.

  20. Espironolactona reduz a pressão arterial e a albuminúria de hipertensos obesos com síndrome metabólica

    Directory of Open Access Journals (Sweden)

    Danielle Guedes Andrade Ezequiel

    2013-03-01

    Full Text Available INTRODUÇÃO: A aldosterona tem sido implicada na fisiopatologia da síndrome metabólica (SM, assim como da hipertensão arterial a ela associada; entretanto, o uso de antagonistas do receptor mineralocorticoide neste grupo de indivíduos foi pouco estudado. OBJETIVOS: Avaliar os efeitos do bloqueio mineralocorticoide no comportamento pressórico, em parâmetros metabólicos, inflamatórios e renais de indivíduos com SM. MÉTODOS: Vinte e nove indivíduos com SM foram avaliados em estudo prospectivo que consistiu de dois períodos: basal (duas semanas, no qual foram obtidos dados demográficos e suspensa a medicação anti-hipertensiva, e período de tratamento, no qual foi administrada espironolactona (25 a 50 mg/dia, por 16 semanas. Em ambos os períodos, foram avaliados marcadores inflamatórios, metabólicos e renais, além da realização da monitorização ambulatorial da pressão arterial. RESULTADOS: Após tratamento com espironolactona, a pressão arterial sistólica e diastólica de 24 horas reduziu de 143,5 ± 15,17 mmHg para 133,2 ± 17,34 mmHg (p = 0,025 e de 85,2 ± 11,10 mmHg para 79,3 ± 11,78 mmHg (p = 0,026, respectivamente. Os níveis de colesterol HDL aumentaram de 44,0 ± 8,67 para 49,0 ± 6,75mg/dL (p = 0,000 e a proteína C reativa reduziu significantemente de 6,3 ± 7,54 mg/L para 4,6 ± 6,30 mg/L. Os níveis de glicemia de jejum, insulina, HOMA-IR e triglicérides não apresentaram alteração significante após bloqueio do receptor mineralocorticoide. A filtração glomerular estimada não se alterou, enquanto o logaritmo da albuminúria reduziu significantemente de 2,5 ± 0,92 para 2,0 ± 0,95. CONCLUSÃO: A administração de espironolactona em monoterapia a hipertensos com SM foi eficaz no controle da hipertensão arterial, reduziu a excreção urinária de albumina e elevou os níveis de colesterol HDL.

  1. Doença hepática gordurosa não alcoólica em escolares obesos Nonalcoholic fatty liver disease in obese children

    Directory of Open Access Journals (Sweden)

    Fabíola Isabel S. Souza

    2008-06-01

    Full Text Available OBJETIVO: Avaliar a prevalência de alterações hepáticas ao ultra-som e de elevação da alanina aminotransferase (ALT em crianças com sobrepeso e obesidade, além de relacionar a presença de alterações com peroxidação lipídica, perfil lipídico e resistência insulínica. MÉTODOS: Estudo transversal, prospectivo e controlado de 67 crianças com sobrepeso/obesidade (38 do sexo feminino e média de idade de 8,6 anos, pareadas por sexo e idade com 65 eutróficas. A avaliação bioquímica consistiu de perfil lipídico (LDL-c, HDL-c e triglicerídeos; ALT; substâncias reativas ao ácido tiobarbitúrico (TBARS; glicemia e insulina, utilizadas para o cálculo do Homeostasis Model Assessment Insulin Resistance (HOMA-IR. A esteatose hepática, avaliada por ultra-sonografia por um único examinador, foi classificada em difusa leve, moderada e grave. RESULTADOS: Elevação de ALT (>40U/L foi encontrada em 3% e alterações ultra-sonográficas do fígado em 57,4% das crianças com sobrepeso e obesidade. O Grupo Sobrepeso/Obesidade apresentou maior percentual de ALT >18U/L (OR 4,2; p=0,0006 e de hipertrigliceridemia (OR 4,2; p18U/L. CONCLUSÕES: A freqüência de ALT >40U/L foi baixa e a de esteatose foi alta. As alterações ultra-sonográficas hepáticas não mostraram associação com o estado nutricional nem com os níveis de ALT. Por sua vez, triglicerídeos aumentados associaram-se com níveis mais elevados de ALT.OBJECTIVE: To evaluate the prevalence of altered hepatic ultrasound and elevated serum alanine aminotransferase (ALT in overweight and obese children, as well as to relate them to lipid peroxidation, lipid profile and insulin resistance. METHODS: A prospective, controlled, cross-sectional study was performed with 67 overweight and obese children (38 female, mean age of 8,6 years paired by gender and age with 65 eutrophic controls. The following parameters were evaluated: lipid profile (LDL-c, HDL-c, triglycerides, ALT, lipid

  2. Formation and spectroscopic characterization of mono-dispersed CdSe nanocrystals

    Institute of Scientific and Technical Information of China (English)

    Miao Yan-Ming; Li Chao-Rong; Cao Li; Liu Rui-Bin; He Yu-Ping; Xie Si-Shen; Zou Bing-Suo

    2005-01-01

    In this article, mono-dispersed hexagonal structure CdSe nanocrystals with polyhedron shape were prepared by an open solvent thermal reaction. They show a discrete excitonic transition structure in the absorption spectra and the minimal photoluminescence (PL) peak full-width at half-maximum of 19nm. The PL quantum yield is about 60%. Transmission electron micrographs, high-resolution transmission electron micrographs, x-ray powder diffraction patterns, UV-vis absorption spectra and PL spectra were obtained for the as-prepared CdSe nanocrystals. The size of the CdSe nanocrystals can be tuned by changing the reaction temperature or time. Due to the improved synthesis method, a different growth mechanism of the CdSe nanocrystals is discussed.

  3. Entire solutions for a mono-stable delay population model in a 2D lattice strip

    Directory of Open Access Journals (Sweden)

    Hai-Qin Zhao

    2014-11-01

    Full Text Available This article concerns the entire solutions of a mono-stable age-structured population model in a 2D lattice strip. In a previous publication, we established the existence of entire solutions related to traveling wave solutions with speeds larger than the minimal wave speed $c_{\\rm min}$. However, the existence of entire solutions related to the minimal wave fronts remains open open question. In this article, we first establish a new comparison theorem. Then, applying the theorem we obtain the existence of entire solutions by mixing any finite number of traveling wave fronts with speeds $c\\geq c_{\\rm min}$, and a solution without the $j$ variable. In particular, we show the relationship between the entire solution and the traveling wave fronts that they originate.

  4. A study on the clinical profile of complicated Plasmodium vivax mono-infections

    Institute of Scientific and Technical Information of China (English)

    Peter George; Lobo Manuel Alexander

    2010-01-01

    Objective:To identify cases of severe Plasmodium vivax (P. vivax) mono-infections among adults. Methods:In this retrospective study, 30 adult patients admitted to medical wards of a tertiary hospital in a malaria endemic urban area from March 2010 to April 2010 were included. The diagnosis of P. vivax malaria was established by peripheral blood film (PBF) examination, and severe malaria was categorized as per World Health Organization guidelines. Results:Complications observed were thrombocytopenia in 28 (93.3%), hepatic dysfunction and jaundice in 13 (43.3%), renal dysfunction in 8 (26.7%), severe anaemia in 3 (10.0%), cerebral malaria in 2 (6.7%), and acute respiratory distress syndrome (ARDS) in 1 (3.3%) of 30 patients. Conclusions:P. vivax malaria with severe complications is common in the investigated area, and an intensive and large-scale study of the disease is necessary.

  5. Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

    Directory of Open Access Journals (Sweden)

    Stefano D'Errico

    2014-07-01

    Full Text Available The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyladenosine or a 1,6-di(adenosin-N6-yl-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamineplatinum(II, is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.

  6. Mono- and bi-functional arenethiols as surfactants for gold nanoparticles: synthesis and characterization

    Directory of Open Access Journals (Sweden)

    Fratoddi Ilaria

    2011-01-01

    Full Text Available Abstract Stable gold nanoparticles stabilized by different mono and bi-functional arenethiols, namely, benzylthiol and 1,4-benzenedimethanethiol, have been prepared by using a modified Brust's two-phase synthesis. The size, shape, and crystalline structure of the gold nanoparticles have been determined by high-resolution electron microscopy and full-pattern X-ray powder diffraction analyses. Nanocrystals diameters have been tuned in the range 2 ÷ 9 nm by a proper variation of Au/S molar ratio. The chemical composition of gold nanoparticles and their interaction with thiols have been investigated by X-ray photoelectron spectroscopy. In particular, the formation of networks has been observed with interconnected gold nanoparticles containing 1,4-benzenedimethanethiol as ligand.

  7. Endospores of B subtilis are pyrogenic and activate Mono Mac 6 cells

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, Erik W; Christensen, Jens D;

    2003-01-01

    The monocytic cell line Mono Mac 6 is sensitive to pyrogens and interleukin-6 secretion is induced after exposure to pyrogens. The aim of this study is to examine the pyrogenic activity and the interleukin-6-inducing capacity of the Gram-positive B. subtilis bacteria, endospores and isolated cell...... in a sandwich immunoassay. B. subtilis bacteria and endospores induce interleukin-6 in a dose-dependent manner. Endospores are less potent than bacteria. Lipoteichoic acid (LTA) isolated from B. subtilis induces interleukin-6 in a dose-dependent manner, whereas muramyl dipeptide (MDP) is unable to induce...... interleukin-6. Lipopolysaccharides (LPS) dose-dependently induce interleukin-6 release, but the curve differs from that of LTA both in shape and offset. The interleukin-6 secretion induced by LPS, LTA and B. subtilis bacteria can be blocked by 73-85% by an antibody directed against CD14, whereas the antibody...

  8. Optimizing seeded casting of mono-like silicon crystals through numerical simulation

    Science.gov (United States)

    Black, Andrés; Medina, Juan; Piñeiro, Axa; Dieguez, Ernesto

    2012-08-01

    Recently, silicon ingots produced by typical multicrystalline casting systems but having monocrystalline features are entering the photovoltaic market. In order to look into the particular properties of this novel method, the normal silicon casting process is numerically simulated, and compared to an optimized mono-like casting process, based on the use of oriented monocrystalline silicon seeds. The seeding process was optimized by reducing the time spent in the melt in order to reduce the back diffusion of harmful non-feedstock metal impurities such as iron, reducing the thermomechanical stress to avoid dislocation multiplication, and decreasing the overall interface curvature. Additionally, the growth conditions in the zone just above the seeds were fine-tuned to increase the production of vacancy point defects, in the hope of achieving "vacancy passivation" of harmful interstitial iron by moving it to substitutional position.

  9. Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.

    Science.gov (United States)

    Rieser, M J; Gu, Z M; Fang, X P; Zeng, L; Wood, K V; McLaughlin, J L

    1996-02-01

    Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). Three of these (1-3) are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. NMR analyses of published model synthetic compounds, prepared cyclized formal acetals, and prepared Mosher ester derivatives permitted the determinations of absolute stereochemistries. Bioassays of the pure compounds, in the brine shrimp test, for the inhibition of crown gall tumors, and in a panel of human solid tumor cell lines for cytotoxicity, evaluated relative potencies. Compound 1 was selectively cytotoxic to colon adenocarcinoma cells (HT-29) in which it was 10,000 times the potency of adriamycin.

  10. Efeitos de misturas de napropamide e simazine no controle de mono e dicotiledoneas em cafeeiros novos

    OpenAIRE

    L.S.P. Cruz; M.C.S.S. NOVO

    1980-01-01

    Com a finalidade de se conhecer a ação de misturas de napropamide e simazine no controle de plantas daninhas mono e dicotiledôneas em cafee iros com dois anos de idade, foi conduzido um experimento de campo em Araras, SP, em 1979/80. 0 delineamento foi o de blocos ao acaso com nove tratamentos e quatro repetições. Os tratamentos foram os seguintes: napropamide a 2,00 kg e 3,00 kg/ha; simazine a 0,50 kg e 0,75 kg/ha; e, misturas de 2,00 kg/ha de napropamide com 0,50 kg e 0,75 kg/ha de simazine...

  11. A Quantum Monte Carlo Study of mono(benzene)TM and bis(benzene)TM Systems

    CERN Document Server

    Bennett, M Chandler; Mitas, Lubos

    2016-01-01

    We present a study of mono(benzene)TM and bis(benzene)TM systems, where TM={Mo,W}. We calculate the binding energies by quantum Monte Carlo (QMC) approaches and compare the results with other methods and available experiments. The orbitals for the determinantal part of each trial wave function were generated from several types of DFT in order to optimize for fixed-node errors. We estimate and compare the size of the fixed-node errors for both the Mo and W systems with regard to the electron density and degree of localization in these systems. For the W systems we provide benchmarking results of the binding energies, given that experimental data is not available.

  12. Probing a General Rule towards Thermodynamic Stabilities of Mono BN-doped Lower Polyenes.

    Science.gov (United States)

    Rouf, Alvi Muhammad; Wu, Jingjing; Zhu, Jun

    2017-03-02

    The BN-doped organic analogues are interesting as aliphatic amineboranes for hydrogen storage, precursors for aromatic borazines and adsorbent cage azaboranes. However, BN-doped aliphatic polyenes remained undeveloped. Herein, we perform theoretical calculations on two mono BN-doped aliphatic lower polyenes, 1,3-butadiene and 1,3,5-hexatriene. A general rule is proposed, i.e., isomers with terminal nitrogen and directly BN-connected, N-B(R), in particular, are of significant thermodynamic stability as compared with their inverse analogues (where boron is at the terminal position). The N-B(R) type isomers are found to be the most stable ones in both polyenes. Isomers with terminal B and N are of intermediate stability. Highly destabilized isomers are those with one terminal methylene group and one terminal heteroatom in the butadiene series, and two terminal methylene groups in the hexatriene series. Rules established here may lead researchers to synthesize isomers with particular thermodynamic stability.

  13. Probing atomic structure and Majorana wavefunctions in mono-atomic Fe chains on superconducting Pb surface

    Science.gov (United States)

    Pawlak, Rémy; Kisiel, Marcin; Klinovaja, Jelena; Meier, Tobias; Kawai, Shigeki; Glatzel, Thilo; Loss, Daniel; Meyer, Ernst

    2016-11-01

    Motivated by the striking promise of quantum computation, Majorana bound states (MBSs) in solid-state systems have attracted wide attention in recent years. In particular, the wavefunction localisation of MBSs is a key feature and is crucial for their future implementation as qubits. Here we investigate the spatial and electronic characteristics of topological superconducting chains of iron atoms on the surface of Pb(110) by combining scanning tunnelling microscopy and atomic force microscopy. We demonstrate that the Fe chains are mono-atomic, structured in a linear manner and exhibit zero-bias conductance peaks at their ends, which we interpret as signature for a MBS. Spatially resolved conductance maps of the atomic chains reveal that the MBSs are well localised at the chain ends (≲25 nm), with two localisation lengths as predicted by theory. Our observation lends strong support to use MBSs in Fe chains as qubits for quantum-computing devices.

  14. A quantum Monte Carlo study of mono(benzene) TM and bis(benzene) TM systems

    Science.gov (United States)

    Bennett, M. Chandler; Kulahlioglu, A. H.; Mitas, L.

    2017-01-01

    We present a study of mono(benzene) TM and bis(benzene) TM systems, where TM = {Mo, W}. We calculate the binding energies by quantum Monte Carlo (QMC) approaches and compare the results with other methods and available experiments. The orbitals for the determinantal part of each trial wave function were generated from several types of DFT functionals in order to optimize for fixed-node errors. We estimate and compare the size of the fixed-node errors for both the Mo and W systems with regard to the electron density and degree of localization in these systems. For the W systems we provide benchmarking results of the binding energies, given that experimental data is not available.

  15. Enzymatic routes for the production of mono- and di-glucosylated derivatives of hydroxytyrosol.

    Science.gov (United States)

    Trincone, Antonio; Pagnotta, Eduardo; Tramice, Annabella

    2012-07-01

    In this work, a new eco-friendly procedure for the synthesis of hydroxytyrosol and tyrosol α-glycosidic derivatives was proposed by using the marine α-glucosidase from Aplysia fasciata, and a commercial tyrosinase from mushroom for the bioconversion of tyrosol glycosidic derivatives into the corresponding hydroxytyrosol products. New hydroxytyrosol mono- and di-saccharide derivatives were synthesized at final concentrations of 9.35 and 10.8 g/l of reaction, respectively, and their antioxidant activity was evaluated by DPPH test. The best antioxidant agent resulted the (3,4-dihydroxyphenyl) ethyl-α-D-glucopyranoside; it showed a radical scavenging activity similar to that of the hydroxytyrosol, together with an increased hydrosolubility. This molecule could be a good response to many food industry demands, always in search of cheap antioxidants with nutritional properties to improve the nutritional value and the quality of foods.

  16. Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monoterpene degradation pathways

    NARCIS (Netherlands)

    Werf, van der M.J.

    2000-01-01

    A Baeyer-Villiger mono-oxygenase (BVMO), catalysing the NADPH- and oxygen-dependent oxidation of the monocyclic monoterpene ketones 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone, was purified to homogeneity from Rhodococcus erythropolis DCL14. Monocyclic monoterpene ketone mono-oxygenase (MMK

  17. Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways

    NARCIS (Netherlands)

    Werf, M.J. van der

    2000-01-01

    A Baeyer-Villiger mono-oxygenase (BVMO), catalysing the NADPH- and oxygen-dependent oxidation of the monocyclic monoterpene ketones 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone, was purified to homogeneity from Rhodococcus erythropolis DCL14. Monocyclic monoterpene ketone mono-oxygenase (MMK

  18. Characterization of microbial arsenate reduction in the anoxic bottom waters of Mono Lake, California

    Science.gov (United States)

    Hoeft, S.E.; Lucas, F.; Hollibaugh, J.T.; Oremland, R.S.

    2002-01-01

    Dissimilatory reduction of arsenate (DAsR) occurs in the arsenic-rich, anoxic water column of Mono Lake, California, yet the microorganisms responsible for this observed in situ activity have not been identified. To gain insight as to which microorganisms mediate this phenomenon, as well as to some of the biogeochemical constraints on this activity, we conducted incubations of arsenate-enriched bottom water coupled with inhibition/amendment studies and Denaturing Gradient Gel Electrophoresis (DGGE) characterization techniques. DAsR was totally inhibited by filter-sterilization and by nitrate, partially inhibited (~50%) by selenate, but only slightly (~25%) inhibited by oxyanions that block sulfate-reduction (molybdate and tungstate). The apparent inhibition by nitrate, however, was not due to action as a preferred electron acceptor to arsenate. Rather, nitrate addition caused a rapid, microbial re-oxidation of arsenite to arsenate, which gave the overall appearance of no arsenate loss. A similar microbial oxidation of As(III) was also found with Fe(III), a fact that has implications for the recycling of As(V) in Mono Lake's anoxic bottom waters. DAsR could be slightly (10%) stimulated by substrate amendments of lactate, succinate, malate, or glucose, but not by acetate, suggesting that the DAsR microflora is not electron donor limited. DGGE analysis of amplified 16S rDNA gene fragments from incubated arsenate-enriched bottom waters revealed the presence of two bands that were not present in controls without added arsenate. The resolved sequences of these excised bands indicated the presence of members of the epsilon (Sulfurospirillum) and delta (Desulfovibrio) subgroups of the Proteobacteria, both of which have representative species that are capable of anaerobic growth using arsenate as their electron acceptor.

  19. Analysis of Gas Membrane Ultra-High Purification of Small Quantities of Mono-Isotopic Silane

    Energy Technology Data Exchange (ETDEWEB)

    de Almeida, Valmor F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Chemical Sciences Division; Hart, Kevin J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Chemical Sciences Division

    2016-09-05

    A small quantity of high-value, crude, mono-isotopic silane is a prospective gas for a small-scale, high-recovery, ultra-high membrane purification process. This is an unusual application of gas membrane separation for which we provide a comprehensive analysis of a simple purification model. The goal is to develop direct analytic expressions for estimating the feasibility and efficiency of the method, and guide process design; this is only possible for binary mixtures of silane in the dilute limit which is a somewhat realistic case. Among the common impurities in crude silane, methane poses a special membrane separation challenge since it is chemically similar to silane. Other potential problematic surprises are: ethylene, diborane and ethane (in this order). Nevertheless, we demonstrate, theoretically, that a carefully designed membrane system may be able to purify mono-isotopic, crude silane to electronics-grade level in a reasonable amount of time and expenses. We advocate a combination of membrane materials that preferentially reject heavy impurities based on mobility selectivity, and light impurities based on solubility selectivity. We provide estimates for the purification of significant contaminants of interest. To improve the separation selectivity, it is advantageous to use a permeate chamber under vacuum, however this also requires greater control of in-leakage of impurities in the system. In this study, we suggest cellulose acetate and polydimethylsiloxane as examples of membrane materials on the basis of limited permeability data found in the open literature. We provide estimates on the membrane area needed and priming volume of the cell enclosure for fabrication purposes when using the suggested membrane materials. These estimates are largely theoretical in view of the absence of reliable experimental data for the permeability of silane. Last but not least, future extension of this work to the non-dilute limit may apply to the recovery of silane from

  20. Analysis of Gas Membrane Ultra-High Purification of Small Quantities of Mono-Isotopic Silane

    Energy Technology Data Exchange (ETDEWEB)

    de Almeida, Valmor F [ORNL; Hart, Kevin J [ORNL

    2016-09-01

    A small quantity of high-value, crude, mono-isotopic silane is a prospective gas for a small-scale, high-recovery, ultra-high membrane purification process. This is an unusual application of gas membrane separation for which we provide a comprehensive analysis of a simple purification model. The goal is to develop direct analytic expressions for estimating the feasibility and efficiency of the method, and guide process design; this is only possible for binary mixtures of silane in the dilute limit which is a somewhat realistic case. Among the common impurities in crude silane, methane poses a special membrane separation challenge since it is chemically similar to silane. Other potential problematic surprises are: ethylene, diborane and ethane (in this order). Nevertheless, we demonstrate, theoretically, that a carefully designed membrane system may be able to purify mono-isotopic, crude silane to electronics-grade level in a reasonable amount of time and expenses. We advocate a combination of membrane materials that preferentially reject heavy impurities based on mobility selectivity, and light impurities based on solubility selectivity. We provide estimates for the purification of significant contaminants of interest. To improve the separation selectivity, it is advantageous to use a permeate chamber under vacuum, however this also requires greater control of in-leakage of impurities in the system. In this study, we suggest cellulose acetate and polydimethylsiloxane as examples of membrane materials on the basis of limited permeability data found in the open literature. We provide estimates on the membrane area needed and priming volume of the cell enclosure for fabrication purposes when using the suggested membrane materials. These estimates are largely theoretical in view of the absence of reliable experimental data for the permeability of silane. Last but not least, future extension of this work to the non-dilute limit may apply to the recovery of silane from

  1. Mono- to few-layered graphene oxide embedded randomness assisted microcavity amplified spontaneous emission source

    Science.gov (United States)

    Das, Pratyusha; Maiti, Rishi; Barman, Prahalad K.; Ray, Samit K.; Shivakiran, Bhaktha B. N.

    2016-02-01

    The realization of optoelectronic devices using two-dimensional materials such as graphene and its intermediate product graphene oxide (GO) is extremely challenging owing to the zero band gap of the former. Here, a novel amplified spontaneous emission (ASE) system based on a GO-embedded all-dielectric one-dimensional photonic crystal (1DPhC) micro-resonator is presented. The mono- to few-layered GO sheet is inserted within a microcavity formed by two 5-bilayered SiO2/SnO2 Bragg reflectors. Significantly enhanced photoluminescence (PL) emission of GO embedded in 1DPhC is explicated by studying the electric field confined within the micro-resonator using the transfer matrix method. The inherent randomness, due to fabrication limitations, in the on-average periodic 1DPhC is exploited to further enhance the PL of the optically active micro-resonator. The 1DPhC and randomness assisted field confinement reduces the ASE threshold of the mono- to few-layered weak emitter making the realization of an ASE source feasible. Consequently, ASE at the microcavity resonance and at the low-frequency band-edge of photonic stop-band is demonstrated. Variation of the detection angle from 5° to 30°, with respect to the sample surface normal allows reallocation of the defect mode ASE peak over a spectral range of 558-542 nm, making the GO-incorporated 1DPhC a novel and attractive system for integrated optic applications.

  2. Mono(imidazolin-2-iminato) actinide complexes: synthesis and application in the catalytic dimerization of aldehydes.

    Science.gov (United States)

    Karmel, Isabell S R; Fridman, Natalia; Tamm, Matthias; Eisen, Moris S

    2014-12-10

    The synthesis of the mono(imidazolin-2-iminato) actinide(IV) complexes [(Im(R)N)An(N{SiMe3)2}3] (3-8) was accomplished by the protonolysis reaction between the respective imidazolin-2-imine (Im(R)NH, R = tBu, Mes, Dipp) and the actinide metallacycles [{(Me3Si)N}2An{κ(2)C,N-CH2SiMe2N(SiMe3)}] (1, An = U; 2, M = Th). The thorium and uranium complexes were obtained in high yields, and their structures were established by single-crystal X-ray diffraction analysis. The mono(imidazolin-2-iminato) actinide complexes 3-8 display short An-N bonds together with large An-N-C angles, indicating strong electron donation from the imidazolin-2-iminato moiety to the metal, corroborating a substantial π-character to the An-N bond. The reactivity of complexes 3-8 toward benzaldehyde was studied in the catalytic dimerization of aldehydes (Tishchenko reaction), displaying low to moderate catalytic activities for the uranium complexes 3-5 and moderate to high catalytic activities for the thorium analogues 6-8, among which 8 exhibited the highest catalytic activity. In addition, actinide coordination compounds showed unprecedented reactivity toward cyclic and branched aliphatic aldehydes in the catalytic Tishchenko reaction mediated by the thorium complex [(Im(Dipp)N)Th{N(SiMe3)2}3] (8), exhibiting high activity even at room temperature. Moreover, complex 8 was successfully applied in the crossed Tishchenko reaction between an aromatic or polyaromatic and an aliphatic cyclic and branched aldehyde, yielding selectively the asymmetrically substituted ester in high yields (80-100%).

  3. Efeito da sibutramina na redução do peso e no perfil metabólico em indivíduos obesos de uma população brasileira

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Menezes

    2010-12-01

    Full Text Available O objetivo deste trabalho é avaliar a eficácia e a segurança da dose de 20 mg/dia de sibutramina em voluntários obesos, com IMC superior a 35, e compará-las com a dose de 10 mg/dia e à mudança de estilo de vida de pacientes com IMC inferior a 35 (a avaliação e a comparação foram realizadas em um período de 24 semanas. Foram submetidos a um estudo transversal 54 voluntários, distribuídos em três grupos de observação: grupo sem tratamento farmacológico (GMEV, grupo com IMC inferior a 35 e uma dose de 10 mg/ dia de sibutramina (G1 e grupo com IMC superior a 35 e dose de 20 mg/ dia de sibutramina (G2. Os parâmetros avaliados foram peso, circunferência abdominal e perfil metabólico. Os grupos submetidos ao tratamento farmacológico demonstraram maior redução do peso (G1: redução média de 9,4% ; G2: redução média de 20,6% quando comparados a indivíduos sem tratamento farmacológico (GMEV: redução de 3,9%, assim como da circunferência abdominal (redução de 7,1%, 12,8% e 3,1% em G1, G2 e GMEV, respectivamente. Em relação aos achados laboratoriais, foram observados redução da glicemia de jejum (14,8%, 22,9% e 5% em G1, G2 e GMEV, respectivamente, aumento do HDL colesterol (31,2%, 40% e 14,2% em G1, G2 e GMEV, respectivamente e redução do colesterol total (29,0%, 32,8% e 13,7% em G1, G2 e GMEV, respectivamente. Os resultados deste estudo demonstram que a dose de 20 mg de sibutramina é uma indicação segura e eficaz em pacientes obesos com IMC superior a 35. Palavras-chave: Sibutramina. Obesidade. Circunferência Abdominal. Dislipidemia. Diabetes Mellitus, Tipo 2. Ciclobutanos. ABSTRACT Effects of sibutramine on weight reduction and metabolic profile in obese individuals in a brazilian population The aim of this study is to assess the efficacy and safety of an oral daily dose of 20 mg sibutramine in obese volunteers (BMI > 35, in comparison with a dose of 10 mg/day and changed lifestyle in patients whose BMI is

  4. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

    Energy Technology Data Exchange (ETDEWEB)

    Craig, Zelieann R., E-mail: zelieann@illinois.edu; Hannon, Patrick R., E-mail: phannon2@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2013-11-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P{sub 4}) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P{sub 4}, androstenedione (A), testosterone (T), estrone (E{sub 1}), and 17β-estradiol (E{sub 2}) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E{sub 2}. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P{sub 4}, A, T, and E{sub 1} that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis

  5. Sources of SOA gaseous precursors in contrasted urban environments: a focus on mono-aromatic compounds and intermediate volatility compounds

    Science.gov (United States)

    Salameh, Therese; Borbon, Agnès; Ait-Helal, Warda; Afif, Charbel; Sauvage, Stéphane; Locoge, Nadine; Bonneau, Stéphane; Sanchez, Olivier

    2016-04-01

    Among Volatile Organic Compounds (VOC), the mono-aromatic compounds so-called BTEX (Benzene, Toluene, Ethylbenzene, and Xylenes) and the intermediate volatility organic compounds (IVOC) with C>12 are two remarkable chemical families having high impact on health, as well as on the production of secondary pollutants like secondary organic aerosols (SOA) and ozone. However, the nature and relative importance of their sources and, consequently, their impact on SOA formation at urban scale is still under debate. On the one hand, BTEX observations in urban areas of northern mid-latitudes do not reconcile with emission inventories; the latter pointing to solvent use as the dominant source compared to traffic. Moreover, a recent study by Borbon et al. (2013) has shown an enrichment in the C7-C9 aromatic fraction in Paris atmosphere by a factor of 3 compared to other cities. Causes would be: (i) differences in gasoline composition, (ii) differences in vehicle fleet composition, and (iii) differences in solvent use related sources. On the other hand, many smog chamber studies have highlighted IVOCs as important SOA precursors over the last decade but their origin and importance in urban areas relative to other precursors like BTEX is still poorly addressed. Here we combined large VOC datasets to investigate sources of BTEX and IVOC in contrasted urban areas by source-receptor approaches and laboratory experiments. Ambient data include multi-site speciated ambient measurements of C2 to C17 VOCs (traffic, urban background, and tunnel) from air quality networks (ie. AIRPARIF in Paris) and intensive field campaigns (MEGAPOLI-Paris, TRANSEMED in Beirut and Istanbul, PHOTOPAQ in Brussels). Preliminary results for Paris suggest that traffic dominates BTEX concentrations while traffic and domestic heating for IVOC (>70%). In parallel, the detailed composition of the fuel liquid phase was determined at the laboratory for typical fuels distributed in Ile de France region (diesel, SP95

  6. Mono-thioesters and di-thioesters by lipase-catalyzed reactions of alpha,omega-alkanedithiols with palmitic acid or its methyl ester.

    Science.gov (United States)

    Weber, N; Klein, E; Vosmann, K; Mukherjee, K D

    2004-06-01

    1- S-Mono-palmitoyl-hexanedithiol and 1- S-mono-palmitoyl-octanedithiol were prepared in high yield (80-90%) by solvent-free lipase-catalyzed thioesterification of palmitic acid with the corresponding alpha,omega-alkanedithiols in vacuo. Similarly, 1,6-di- S-palmitoyl-hexanedithiol and 1,8-di- S-palmitoyl-octanedithiol were prepared in moderate yield (50-60%) by solvent-free lipase-catalyzed thioesterification of palmitic acid with 1- S-Mono-palmitoyl-hexanedithiol and 1- S-mono-palmitoyl-octanedithiol, respectively. An immobilized lipase preparation from Rhizomucor miehei (Lipozyme RM IM) was more effective than a lipase B preparation from Candida antarctica (Novozym 435) or a lipase preparation from Thermomyces lanuginosus (Lipozyme TL IM). Lipase-catalyzed transthioesterifications of methyl palmitate with alpha,omega-alkanedithiols using the same enzymes were less effective than thioesterification for the preparation of the corresponding 1- S-mono-palmitoyl thioesters.

  7. α1/α2-Adrenoceptor agonist selectivity of mono- and dihydroxy-2-N,N-di-n-propylaminotetralins

    NARCIS (Netherlands)

    Timmermans, P.B.M.W.M.; Mathy, M.J.; Wilffert, B.

    1984-01-01

    The pressor activities and the identity of the postjunctonal α-adrenoceptors involved were determined for a series of congeneric mono- and dihydroxy-substituted 2-N,N-di-n-propylaminotetralins and N,N-di-n-propyldopamine (DPDA) following i.v. administration to pithed normotensive rats. The affinity

  8. Metabolism of mono- and dihalogenated C1 and C2 compounds by Xanthobacter autotrophicus growing on 1,2-dichloroethane

    NARCIS (Netherlands)

    Torz, Maciej; Wietzes, Piet; Beschkov, Venko; Janssen, Dick B.

    2007-01-01

    The conversion of and toxic effects exerted by several mono- and dihalogenated C1 and C2 compounds on cultures of Xanthobacter autotrophicus GJ10 growing on 1,2-dichloroethane were investigated. Bromochloromethane, dibromomethane and 1-bromo-2-chloroethane were utilized by strain GJ10 in batch cultu

  9. A systematic study of the isothermal crystallization of the mono-alcohol n-butanol monitored by dielectric spectroscopy

    DEFF Research Database (Denmark)

    Jensen, Mikkel Hartmann; Hecksher, Tina; Niss, Kristine;

    2015-01-01

    Isothermal crystallization of the mono-hydroxyl alcohol n-butanol was studied with dielectric spectroscopy in real time. The crystallization was carried out using two different sample cells at 15 temperatures between 120 K and 134 K. Crystallization is characterized by a decrease of the dielectric...

  10. Lattice-Boltzmann simulations of low-Reynolds-number flow past mono- and bidisperse arrays of spheres

    NARCIS (Netherlands)

    Hoef, van der M.A.; Beetstra, R.; Kuipers, J.A.M.

    2005-01-01

    We report on lattice-Boltzmann simulations of slow fluid flow past mono- and bidisperse random arrays of spheres. We have measured the drag force on the spheres for a range of diameter ratios, mass fractions and packing fractions; in total, we studied 58 different parameter sets. Our simulation data

  11. MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate

    Directory of Open Access Journals (Sweden)

    Erich K. Odermatt

    2012-01-01

    Full Text Available A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strength in vivo and is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ has no residual strength in vivo after 12 weeks. In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication.

  12. A comparative study of Mono Mac 6 cells, isolated mononuclear cells and Limulus amoebocyte lysate assay in pyrogen testing

    DEFF Research Database (Denmark)

    Moesby, Lise; Jensen, S; Hansen, E W;

    1999-01-01

    Pyrogen induced secretion of interleukin 6 (IL-6) in Mono Mac 6 (MM6) cells was measured. The ability of the MM6 cell culture to detect pyrogens was compared to the Limulus amoebocyte lysate (LAL) test and isolated mononuclear cells (MNC). The detection limit of MM6 for lipopolysaccharide (LPS...

  13. Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet

    DEFF Research Database (Denmark)

    Pedersen, Natalia; Vegh, Zsuzsanna; Burisch, Johan

    2014-01-01

    .ibs.constant-care.dk). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable oligo-, di-, mono-saccharides and polyols (FODMAP) diet (LFD) was introduced for the next 6 wk while continuing...

  14. Separation of middle rare earths by solvent extraction using 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester as an extractant

    Institute of Scientific and Technical Information of China (English)

    Danilo; Fontana; Loris; Pietrelli

    2009-01-01

    The extraction of the trivalent middle rare earths from chloride media by kerosene solutions of 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester as an extractant was studied. The separation factors between the elements using solution simulating wastes from NiMH spent batteries have been evaluated: the order of the extractive ability of extractant can be confirmed in ThGdEuSm.

  15. A load-displacement based approach to assess the bearing capacity and deformations of mono-bucket foundations

    DEFF Research Database (Denmark)

    Vahdatirad, Mohammadjavad; Diaz, Alberto Troya; Nielsen, Søren

    2016-01-01

    It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load...

  16. Correlation of Late-Pleistocene Lake-Level Oscillations in Mono Lake, California, with North Atlantic Climate Events

    Science.gov (United States)

    Benson, L.V.; Lund, S.P.; Burdett, J.W.; Kashgarian, Michaele; Rose, T.P.; Smoot, J.P.; Schwartz, M.

    1998-01-01

    Oxygen-18 (18O) values of sediment from the Wilson Creek Formation, Mono Basin, California, indicate three scales of temporal variation (Dansgaard-Oeschger, Heinrich, and Milankovitch) in the hydrologic balance of Mono Lake between 35,400 and 12,900 14C yr B.P. During this interval, Mono Lake experienced four lowstands each lasting from 1000 to 2000 yr. The youngest low-stand, which occurred between 15,500 and 14,000 14C yr B.P., was nearly synchronous with a desiccation of Owens Lake, California. Paleomagnetic secular variation (PSV) data indicate that three of four persistent lowstands occurred at the same times as Heinrich events H1, H2, and H4. 18O data indicate the two highest lake levels occurred ???18,000 and ???13,100 14C yr B.P., corresponding to passages of the mean position of the polar jet stream over the Mono Basin. Extremely low values of total inorganic carbon between 26,000 and 14,000 14C yr B.P. indicate glacial activity, corresponding to a time when summer insolation was much reduced. ?? 1998 University of Washington.

  17. A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

    NARCIS (Netherlands)

    Cankar, K.; van Houwelingen, A.; Bosch, H.J.; Sonke, T.; Bouwmeester, H.; Beekwilder, J.P.

    2011-01-01

    Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene syntha

  18. Dynamics of polyelectrolyte adsorption and colloidal flocculation upon mixing studied using mono-dispersed polystyrene latex particles

    NARCIS (Netherlands)

    Feng, Lili; Cohen Stuart, Martien; Adachi, Yasuhisa

    2015-01-01

    The dynamic behavior of polyelectrolytes just after their encounter with the surface of bare colloidal particles is analyzed, using the flocculation properties of mono-dispersed polystyrene latex (PSL) particles. Applying a Standardized Colloid Mixing (SCM) approach, effects of ionic strength and

  19. Synthesis of mono-fluorinated functionalized cyclopropanes and aziridines using the α-fluorovinyl diphenyl sulfonium salt.

    Science.gov (United States)

    Hirotaki, Kensuke; Takehiro, Yui; Kamaishi, Ryo; Yamada, Yasunori; Hanamoto, Takeshi

    2013-09-18

    The α-fluorovinyl diphenyl sulfonium salt 1 is attractive due to its high potential for the synthesis of mono-fluorinated cyclopropanes and aziridines as useful three-membered rings. The synthetically useful salt 1 is readily prepared from α-fluorovinyl phenyl sulfide and diphenyl iodonium salt in one step.

  20. 21 CFR 582.4521 - Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4521 Section 582.4521 Food and... Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat-forming... oils, or edible fat-forming fatty acids. (b) Conditions of use. This substance is generally...

  1. Mixed mono- and multilayers of poly(isocyanide)s with non-linear optically active side chains

    NARCIS (Netherlands)

    Teerenstra, M.N.; Hagting, J.G.; Oostergetel, G.T.; Schouten, A.J.; Devillers, M.A.C.; Nolte, R.J.M.

    1994-01-01

    The properties and structure of Langmuir-Blodgett mono- and multilayers of several poly(isocyanide)s with non-linear optically active side-chains were studied. These polymers formed very rigid layers or layers which appeared to be unstable. To circumvent this problem they were mixed with other poly(

  2. Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal

    NARCIS (Netherlands)

    Peters, A.K.; Leonards, P.E.G.; Zhao, B.; Bergman, A.; Denison, M.S.; Berg, van den M.

    2006-01-01

    The TEF system for dioxin-like compounds has included assignment of TEF values for mono-ortho polychlorinated biphenyls (MO-PCBs). Small traces of aryl hydrocarbon receptor (AhR)-active impurities could result in artifactually higher relative potency (REP) values. MO-PCBs -105, -118, -156, and -167

  3. Ammonia and hydrogen sulfide concentration and emission patterns for mono-slope beef cattle facilities in the Northern Great Plains

    Science.gov (United States)

    Mono-slope buildings are one type of roofed and confined cattle feeding facility that is becoming increasingly popular in the Northern Great Plains. In response to questions and concerns about the barn environment and air quality regulations, the objectives of this study were to determine gas concen...

  4. On Hydrogen Bonding in the Intramolecularly Chelated Taitomers of Enolic Malondialdehyde and its Mono- and Dithio-Analogues

    DEFF Research Database (Denmark)

    Carlsen, Lars; Duus, Fritz

    1980-01-01

    The intramolecular hydrogen bondings in enolic malondialdehyde and it mono- and dithio-analogues have been evaluated by a semiempricial SCF–MO–CNDO method. The calculations predict that the hydrogen bonds play an important part in the stabilities of malondialdehyde and monothiomalondialdehyde, wh...

  5. Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients.

    Science.gov (United States)

    Zhu, Jia-Wu; Liu, Feng-Liang; Mu, Dan; Deng, De-Yao; Zheng, Yong-Tang

    2016-06-01

    Host restriction factors and type I interferon are important in limiting HIV and HCV infections, yet the role of HIV, HCV mono- and co-infection in regulating these antiviral genes expression is not clear. In this study, we measured the levels of TRIM5α, TRIM22, APOBEC3G, and IFN-α, -β mRNA expression in peripheral blood mononuclear cells of 43 HIV mono-infected, 70 HCV mono-infected and 64 HIV/HCV co-infected patients along with 98 healthy controls. We also quantified HIV and HCV viral loads in mono- and co-infected patients. The results showed that HCV, HIV mono- and co-infection differentially increased TRIM22, APOBEC3G, and IFN-α, -β mRNA expression while the mRNA expression of TRIMα was upregulated only by HCV-mono infection. HIV/HCV co-infection was associated with higher viral load, compared to either HIV or HCV mono-infection. Additionally, we showed TRIMα and TRIM22 positively correlated with IFN-α, -β, which could be dysregulated by HIV, HCV mono- and co-infection. Furthermore, we found TRIM22 negatively correlated with HCV viral load in mono-infected patients and APOBEC3G positively correlated with HCV viral load in co-infected patients. Collectively, our findings suggest the potential role of restriction factors in restricting HIV, HCV mono- and co-infection in vivo, which appears to be a therapeutic target for potential drug discovery.

  6. Análisis retrospectivo de las enfermedades parasitarias del mono ardilla (Saimiri sciureus en dos condiciones ex situ en el noroccidente de los Andes suramericanos

    Directory of Open Access Journals (Sweden)

    Laura Catalina Botero C.

    2011-12-01

    Full Text Available El mono ardilla (Cebidae: Saimiri sciureus es una especie de primate neotropical. La mayor susceptibilidad a la presencia de parásitos en estos primates se puede deber a las condiciones ex situ a las que se encuentran sometidos, en donde se exponen a diferentes factores ambientales y de manejo. A partir de las historias clínicas de una población de 94 Saimiri sciureus del Parque Zoológico Jaime Duque (PZJD y de la Unidad de Rescate y Rehabilitación de Animales Silvestres (Urras, instituciones ubicadas al noroccidente de los Andes suramericanos, se determinó la presencia de los parásitos diagnosticados en estas dos condiciones (exhibición y rehabilitación, respectivamente, estableciendo la posible asociación con la edad, el sexo, la sintomatología y los medicamentos. Se utilizaron histogramas y prueba de chi cuadrado para definir las diferencias de parásitos en estos dos lugares y poder determinar la mayor frecuencia presente en Saimiri sciureus. Por otro lado, el limitado conocimiento y los estudios parasitológicos de estos primates delimitan la gestión pública y dificultan el establecimiento de posibles zoonosis.

  7. InfluÃncia do exercÃcio de nataÃÃo sobre a regeneraÃÃo do nervo mediano em ratos Wistar controles e obesos apÃs protocolo de lesÃo por compressÃo nervosa

    OpenAIRE

    JosinÃia Gresele Coradini

    2014-01-01

    Atualmente a obesidade à considerada uma desordem nutricional comum, sendo um dos mais relevantes problemas de saÃde pÃblica na sociedade moderna e um possÃvel fator de risco para sÃndrome do tÃnel do carpo, a qual à a patologia mais relacionada à compressÃo do nervo mediano. Esta pesquisa à de carÃter experimental com abordagem quantitativa e qualitativa tendo como objetivo avaliar a influÃncia do exercÃcio de nataÃÃo como terapia na regeneraÃÃo nervosa perifÃrica de ratos controles e obesos...

  8. Evaluación del estado de salud o emfermedad del niño y el adolescente obeso mediante el análisis de la patología subclínica y clínica asociadas

    OpenAIRE

    2014-01-01

    Esta tesis consta de un prefacio más ocho capítulos que se interconectan entre sí con el fin de realizar una evaluación global del estado de salud o enfermedad del niño y el adolescente obeso mediante el análisis de la patología subclínica y clínica asociadas. Objetivos. 1) Analizar gráficas de crecimiento idóneas para la correcta detección de obesidad infanto-juvenil. 2) Determinar la prevalencia de comorbilidad asociada a la obesidad infanto-juvenil. 3) Analizar la presencia de factores de ...

  9. Avaliação da força muscular respiratória em crianças e adolescentes com sobrepeso/obesos Evaluation of respiratory muscle strength in overweight/obese children and adolescents

    Directory of Open Access Journals (Sweden)

    Sandra Quintino Santiago

    2008-06-01

    Full Text Available OBJETIVO: Avaliar a força muscular respiratória de crianças e adolescentes com sobrepeso ou obesidade. MÉTODOS: Estudo transversal com crianças e adolescentes entre quatro e 15 anos de idade de duas instituições de ensino fundamental e uma clínica de nutrição. As crianças foram avaliadas e classificadas em dois grupos, de acordo com a curva proposta pelo National Center for Health Statistics: sobrepeso/obesos (GSO, índice de massa corpórea (IMC em relação à idade e ao sexo acima do percentil 85 e eutróficos (GE, IMC entre percentil 5 e 85. Para avaliar as pressões inspiratória máxima (PImax e expiratória máxima (PEmax foram realizadas três medidas com um manovacuômetro, considerando-se a maior medida a partir da capacidade máxima inspiratória e expiratória. Aplicou-se o teste t para as variáveis quantitativas e o qui-quadrado para as qualitativas. Para ajuste das covariáveis, foi feita a análise de covariância, sendo significante pOBJECTIVE: Evaluate respiratory muscle strength in overweight/obese children and adolescents. METHODS: This cross-sectional study enrolled patients between four and 15 years old, classified according to the National Center for Health Statistics curve for body mass index (BMI: Overweight/Obese Group (OG, BMI> 85th percentile and Normal Weight Group (NG, BMI between 5th and 85th percentile. Manuvacuometer was used to measure maximal inspiratory pressure (MaxInspP and maximal expiratory pressure (MaxExpP. Three measurements were obtained using the maximum pulmonary effort and the higher value was considered. Variables were compared by t test chi-square test. Adjustment of possible covariants was made by analysis of covariance, being significant p<0.05. RESULTS: 69 children were included: 37 (54% in the OG and 32 (46% in the NG. Obese patients were younger: 9.8±2.3 versus 10.9±1.9 years (p=0.031. MaxInspP was 71.4±24.9cmH2O in the OG and 89.6±19.6cmH2O (p=0.002. MaxExpP was 71.9±24.8cmH2

  10. Análise da função respiratória em pacientes obesos submetidos à operação Fobi-Capella Respiratory function in obese patients submitted to Fobi-Capella operation

    Directory of Open Access Journals (Sweden)

    Áurea Maria Oliveira da Silva

    2007-10-01

    Full Text Available INTRODUÇÃO: O objetivo deste trabalho foi mensurar quantitativamente essas alterações respiratórias desses pacientes comparando-os até 30 dias de pós-operatório. MÉTODO: Foram realizadas avaliações respiratórias nos períodos pré e pós-operatório de cirurgia bariátrica em obesos mórbidos com IMC superior a 39kg/m², através de gasometria arterial, prova de função respiratória, manovacuômetria, incentivador da respiração e cirtometrias. Foram realizadas também orientações fisioterápicas respiratórias e tratamento no pós-operatório, com dados comparativos entre as avaliações feitas no préoperatório, no 1º, 14º·e 30º dia pós-operatórios. RESULTADOS: Até o 30º dia de pós-operatório, esses indivíduos não obtiveram diferença significativa nos parâmetros estudados, não havendo, em decorrência do tratamento fisioterápico, complicações respiratórias. CONCLUSÃO: Não houve alterações dos parâmetros analisados, nem complicações respiratórias neste estudo com intervenção fisioterápica pré e pós-operatório de cirurgia bariátrica. Estudos devem ser realizados, para mensuração de um tempo maior de pós-operatório e de exercícios específicos, podendo, assim apresentar resultados diferentes.BACKGROUND: The objective this study was to measure quantitatively those breathing alterations until 30 days postoperative. METHOD: Breathing evaluations were accomplished before and after bariatric surgery, in morbid obese with IMC greater than 39 kg/m², through arterial gasometry, spirometry function, manovacuometry, to motivate breathing and circumferences. They were breathing physiotherapeutic accomplished, orientations and treatment in the postoperative, with comparative data among evaluations in the 1st, 14th ·e 30th postoperative day. RESULTS: Until the 30th postoperative day, those individuals didn't achieve significant differences in the evaluated parameters, and showed no breathing

  11. Dwelling and Travel: Octavio Paz and El mono gramático

    Directory of Open Access Journals (Sweden)

    Susan Briante

    2008-01-01

    Full Text Available A partir du prétexte de ces quelques mots : « le mieux serait de suivre le chemin de Galta », Octavio Paz commence une de ses œuvres les plus fascinantes et complexes : « Le singe grammairien ». Publié originairement en français, en 1972, ce texte apparaît comme un récit de voyage du séjour de l’auteur en Inde. Cependant, à travers ses descriptions méticuleuses des paysages de l’Inde et une astucieuse narration à la première personne, le texte serpente tel un sentier peu fréquenté à travers des explorations métapoétiques. Cet article replace « Le singe grammairien » dans la tradition de différents textes surréalistes - dont « Souvenir du Mexique » d’André Breton - qui explorent la confrontation avec l’Autre dans le contexte d’une révélation spirituelle. En situant cette investigation langagière dans le cadre de la contemplation d’un paysage exotique, Paz réalise ce que le critique James Clifford aurait appelé « une ethnographie moderne des conjonctures ».With little more pretext than the words : “lo mejor será escoger el camino de Galta,” Octavio Paz begins one of his most compelling and perplexing works : "El mono gramático." Published originally in French in 1972, the text appears to be a travelogue from Paz’s time in India. But with its meticulous descriptions of Indian landscapes and an astute first person narration, the text winds like a rarely traveled path through metapoetic explorations. This paper considers "El mono gramático" within the tradition of several Surrealist texts-Andre Breton’s “Souvenir du Mexique,” among them-that narrate the confrontation with the Other in the context of a spiritual revelation. By situating this inquisition of language within the contemplation of an exotic landscape, Paz achieves what the cultural critic James Clifford would call “a modern ethnography of conjunctures.”

  12. The Mono Arch, eastern Sierra region, California: Dynamic topography associated with upper-mantle upwelling?

    Science.gov (United States)

    Jayko, A.S.

    2009-01-01

    A broad, topographic flexure localized east of and over the central and southern Sierra Nevada, herein named the Mono Arch, apparently represents crustal response to lithospheric and/or upper-mantle processes, probably dominated by mantle upwelling within the continental interior associated Pacific-North American plate-boundary deformation. This zone of flexure is identified through comparison between the topographic characteristics of the active Cascade volcanic arc and backarc regions with the analogous former arc and backarc in the Sierra Nevada and eastern Sierra Nevada. Serial topographic profiles measured normal to the modern Cascade backarc reveal an accordance of topographic lows defined by valley floors with an average minimum elevation of ???1400-1500m for over 175km to the southeast. Although the accordance drops in elevation slightly to the south, the modern Cascade backarc region is remarkably level, and is characterized by relief up to ???750m above this baseline elevation. By contrast, serial topographic profiles over the former arc and backarc transitions of the eastern Sierra region exhibit a regional anticlinal warping defined by accordant valley floors and by a late Miocene-early Pliocene erosion surface and associated deposits. The amplitude of this flexure above regionally flat baseline elevations to the east varies spatially along the length of the former Sierran arc, with a maximum of ???1000m centred over the Bridgeport Basin. The total zone of flexure is approximately 350km long N-S and 100km wide E-W, and extends from Indian Wells Valley in the south to the Sonora Pass region in the north. Previous geophysical, petrologic, and geodetic studies suggest that the Mono Arch overlies a zone of active mantle upwelling. This region also represents a zone crustal weakness formerly exploited by the middle-to-late Miocene arc and is presently the locus of seismic and volcanic activities. This seismic zone, which lies east of the Sierra Nevada block

  13. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin.

    Science.gov (United States)

    Guo, Wen-Jie; Zhang, Yang-Miao; Zhang, Li; Huang, Bin; Tao, Fei-Fei; Chen, Wei; Guo, Zi-Jian; Xu, Qiang; Sun, Yang

    2013-07-01

    Failure to engage apoptosis appears to be a leading mechanism of resistance to traditional platinum drugs in patients with ovarian cancer. Therefore, an alternative strategy to induce cell death is needed for the chemotherapy of this apoptosis-resistant cancer. Here we report that autophagic cell death, distinct from cisplatin-induced apoptosis, is triggered by a novel monofunctional platinum (II) complex named Mono-Pt in human ovarian carcinoma cells. Mono-Pt-induced cell death has the following features: cytoplasmic vacuolation, caspase-independent, no nuclear fragmentation or chromatin condensation, and no apoptotic bodies. These characteristics integrally indicated that Mono-Pt, rather than cisplatin, initiated a nonapoptotic cell death in Caov-3 ovarian carcinoma cells. Furthermore, incubation of the cells with Mono-Pt but not with cisplatin produced an increasing punctate distribution of microtubule-associated protein 1 light chain 3 (LC3), and an increasing ratio of LC3-II to LC3-I. Mono-Pt also caused the formation of autophagic vacuoles as revealed by monodansylcadaverine staining and transmission electron microscopy. In addition, Mono-Pt-induced cell death was significantly inhibited by the knockdown of either BECN1 or ATG7 gene expression, or by autophagy inhibitors 3-methyladenine, chloroquine and bafilomycin A 1. Moreover, the effect of Mono-Pt involved the AKT1-MTOR-RPS6KB1 pathway and MAPK1 (ERK2)/MAPK3 (ERK1) signaling, since the MTOR inhibitor rapamycin increased, while the MAPK1/3 inhibitor U0126 decreased Mono-Pt-induced autophagic cell death. Taken together, our results suggest that Mono-Pt exerts anticancer effect via autophagic cell death in apoptosis-resistant ovarian cancer. These findings lead to increased options for anticancer platinum drugs to induce cell death in cancer.

  14. /Cu-Al System

    Science.gov (United States)

    Kish, Orel; Froumin, Natalya; Aizenshtein, Michael; Frage, Nachum

    2014-05-01

    Wettability and interfacial interaction of the Ta2O5/Cu-Al system were studied. Pure Cu does not wet the Ta2O5 substrate, and improved spreading is achieved when relatively a high fraction of the active element (~40 at.% Al) was added. The Al2O3 and AlTaO4 phases were observed at the Ta2O5/Cu-Al interface. A thermodynamic evaluation allowed us to suggest that the lack of wetting bellow 40 at.% Al is due to the presence of a native oxide, which covers the drop. The conditions of the native oxide decomposition and the formation of the volatile Al2O suboxide strongly depend on the vacuum level during sessile drop experiments and the composition of the Cu-Al alloy. In our case, Al contents greater than 40% provides thermodynamic conditions for the formation of Al2O (as a result of Al reaction with Al2O3) and the drop spreading. It was suggested that the final contact angle in the Ta2O5/Cu-Al system (50°) is determined by Ta adsorption on the newly formed alumina interlayer.

  15. Hot-electron real-space transfer and longitudinal transport in dual AlGaN/AlN/{AlGaN/GaN} channels

    Science.gov (United States)

    Šermukšnis, E.; Liberis, J.; Matulionis, A.; Avrutin, V.; Ferreyra, R.; Özgür, Ü.; Morkoç, H.

    2015-03-01

    Real-space transfer of hot electrons is studied in dual-channel GaN-based heterostructure operated at or near plasmon-optical phonon resonance in order to attain a high electron drift velocity at high current densities. For this study, pulsed electric field is applied in the channel plane of a nominally undoped Al0.3Ga0.7N/AlN/{Al0.15Ga0.85N/GaN} structure with a composite channel of Al0.15Ga0.85N/GaN, where the electrons with a sheet density of 1.4 × 1013 cm-2, estimated from the Hall effect measurements, are confined. The equilibrium electrons are situated predominantly in the Al0.15Ga0.85N layer as confirmed by capacitance-voltage experiment and Schrödinger-Poisson modelling. The main peak of the electron density per unit volume decreases as more electrons occupy the GaN layer at high electric fields. The associated decrease in the plasma frequency induces the plasmon-assisted decay of non-equilibrium optical phonons (hot phonons) confirmed by the decrease in the measured hot-phonon lifetime from 0.95 ps at low electric fields down below 200 fs at fields of E \\gt 4 kV cm-1 as the plasmon-optical phonon resonance is approached. The onset of real-space transfer is resolved from microwave noise measurements: this source of noise dominates for E \\gt 8 kV cm-1. In this range of fields, the longitudinal current exceeds the values measured for a mono channel reference Al0.3Ga0.7N/AlN/GaN structure. The results are explained in terms of the ultrafast decay of hot phonons and reduced alloy scattering caused by the real-space transfer in the composite channel.

  16. The base-free chemoselective ring opening of epoxides with carboxylic acids using [bmim]Br: a rapid entry into 1,2-diol mono-esters synthesis.

    Science.gov (United States)

    Rad, Mohammad Navid Soltani; Behrouz, Somayeh

    2013-02-01

    A facile and highly convenient base-free protocol for the chemoselective preparation of 1,2-diol mono-esters is described. In this method, the regioselective ring opening of epoxides with carboxylic acids in the presence of [bmim]Br furnishes the corresponding 1,2-diol mono-esters in excellent yields. This method is efficient for various structurally diverse epoxides and carboxylic acids and it can be efficiently applied for the scale up synthesis of 1,2-diol mono-esters in reasonable to good yields. [bmim]Br remarkably influences the reaction progress and acts as both solvent and catalyst in this protocol.

  17. Aussprache als motorische Fertigkeit

    DEFF Research Database (Denmark)

    Bonner, Maria

    2013-01-01

    Authentische Aussprache gilt im Fremdsprachenunterricht als schwer erreichbares Ziel, fremdsprachlicher Akzent wird als nahezu unvermeidbar gesehen. Weder die Hypothese einer kritischen Periode für den Erwerb einer authentischen Aussprache noch das Konzept der Fossilierung im Sprachlernprozess...

  18. Amyotrophic Lateral Sclerosis (ALS)

    Science.gov (United States)

    ... ALS Neurons' broken machinery piles up in ALS Esclerosis Lateral Amiotrófica Dormant viral genes may awaken to ... Dementia Information Page Multifocal Motor Neuropathy Information Page Multiple Sclerosis Information Page Muscular Dystrophy Information Page Myasthenia ...

  19. Synthesis of mono and multidomain YIG particles by chemical coprecipitation or ceramic procedure

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Garcia, L. [Departamento de Materiales Nanoestructurados, Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN), Principado de Asturias - Consejo superior de Investigaciones Cientificas (CSIC) - Universidad de Oviedo - UO, Parque Tecnologico de Asturias, 33428 Llanera, Asturias (Spain); Suarez, M., E-mail: m.suarez@cinn.e [Departamento de Materiales Nanoestructurados, Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN), Principado de Asturias - Consejo superior de Investigaciones Cientificas (CSIC) - Universidad de Oviedo - UO, Parque Tecnologico de Asturias, 33428 Llanera, Asturias (Spain); Menendez, J.L. [Departamento de Materiales Nanoestructurados, Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN), Principado de Asturias - Consejo superior de Investigaciones Cientificas (CSIC) - Universidad de Oviedo -UO, Parque Tecnologico de Asturias, 33428 Llanera, Asturias (Spain)

    2010-04-09

    Yttrium iron garnet powders have been synthesized by chemical coprecipitation using two different precursors, nitrates and chlorides, and by an oxides mixture route. It is shown that depending on the precursors and synthesis conditions used pure yttrium iron garnet powders can be obtained with a mono or multidomain magnetic behaviour. The yttrium iron garnet crystalline structure, as studied by Raman spectroscopy, was already formed after calcination at temperatures as low as 800 {sup o}C when the nitrate precursors were used. However, calcination temperatures of up to 1100 {sup o}C were required to obtain yttrium iron garnet powders when the precursors were chlorides or when the oxides mixture route was chosen. The saturation magnetization of the powders correlates well with the structural characterization: when nitrate precursors were used, the saturation magnetization was already close to the bulk value, 26.8 emu/cm{sup 3}, after calcination at 800 {sup o}C. However, the saturation magnetization of the powders obtained by the chlorides and oxides mixture routes was close to zero up to calcination temperatures of 1100 {sup o}C. Finally, both the chlorides and the oxides mixture routes yield multidomain micron sized yttrium iron garnet powders, whereas the nitrates route led to monodomain submicron sized powders.

  20. Glass-liquid-glass reentrance in mono-component colloidal dispersions

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez-Gonzalez, P E; Medina-Noyola, M [Instituto de Fisica ' Manuel Sandoval Vallarta' , Universidad Autonoma de San Luis Potosi, Alvaro Obregon 64, 78000 San Luis Potosi, SLP (Mexico); Vizcarra-Rendon, A [Unidad Academica de Fisica, Universidad Autonoma de Zacatecas, Paseo la Bufa y Calzada Solidaridad, 98600, Zacatecas, Zac. (Mexico); Guevara-Rodriguez, F de J [Coordinacion de IngenierIa Molecular, Instituto Mexicano del Petroleo, Eje Central Lazaro Cardenas 152, 07730 Mexico, DF (Mexico)

    2008-05-21

    The self-consistent generalized Langevin equation (SCGLE) theory of colloid dynamics is employed to describe the ergodic-non-ergodic transition in model mono-disperse colloidal dispersions whose particles interact through hard-sphere plus short-ranged attractive forces. The ergodic-non-ergodic phase diagram in the temperature-concentration state space is determined for the hard-sphere plus attractive Yukawa model within the mean spherical approximation for the static structure factor by solving a remarkably simple equation for the localization length of the colloidal particles. Finite real values of this property signals non-ergodicity and determines the non-ergodic parameters f(k) and f{sub s}(k). The resulting phase diagram for this system, which involves the existence of reentrant (repulsive and attractive) glass states, is compared with the corresponding prediction of mode coupling theory. Although both theories coincide in the general features of this phase diagram, there are also clear qualitative differences. One of the most relevant is the SCGLE prediction that the ergodic-attractive glass transition does not preempt the gas-liquid phase transition, but always intersects the corresponding spinodal curve on its high-concentration side. We also calculate the ergodic-non-ergodic phase diagram for the sticky hard-sphere model to illustrate the dependence of the predicted SCGLE dynamic phase diagram on the choice of one important constituent element of the SCGLE theory.

  1. Prediction of mono- and polycyclic aromatic hydrocarbon degradation in spiked soils using cyclodextrin extraction

    Energy Technology Data Exchange (ETDEWEB)

    Allan, Ian J. [School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom); Semple, Kirk T. [Department of Environmental Sciences, Lancaster University, LA1 4YQ (United Kingdom); Hare, Rina [Alcontrol Laboratories, Chester CH5 3US (United Kingdom); Reid, Brian J. [Alcontrol Laboratories, Chester CH5 3US (United Kingdom)]. E-mail: b.reid@uea.ac.uk

    2006-11-15

    In this study, an aqueous-based hydroxypropyl-{beta}-cyclodextrin (HPCD) extraction technique was assessed for its capacity to determine the microbially degradable fraction of mono- and polycyclic aromatic hydrocarbons in four dissimilar soils. A linear relationship (slope = 0.90; R {sup 2} = 0.89), approaching 1:1 between predicted and observed phenanthrene mineralization, was demonstrated for the cyclodextrin extraction; however, the water only extraction underestimated the microbially available fraction by a factor of three (slope = 3.35; R {sup 2} = 0.64). With respect to determining the mineralizable fraction of p-cresol in soils, the cyclodextrin extraction (slope = 0.94; R {sup 2} = 0.84) was more appropriate than the water extraction (slope = 1.50; R {sup 2} = 0.36). Collectively, these results suggested that the cyclodextrin extraction technique was suitable for the prediction of the mineralizable fraction of representative PAHs and phenols present in dissimilar soils following increasing soil-contaminant contact times. The assessment of the microbial availability of contaminants in soils is important for a more representative evaluation of soil contamination. - An aqueous-based HPCD extraction technique was more appropriate than the water extraction in prediction of the mineralizable fraction of phenanthrene and p-cresol present in a range of dissimilar soils.

  2. Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents

    Directory of Open Access Journals (Sweden)

    Jing Zhang

    2014-11-01

    Full Text Available The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO, relative to currently available inotropic drugs, has prompted us to intensively research and develop LZDO as a potent positive inotropic agent. In this study, to obtain LZDO alternatives for oral chronic administration, a series of long-chain fatty carboxylic mono- and dual-esters of LZDO were synthesized, and preliminarily evaluated for physicochemical properties and bioconversion. Enhanced lipophilic properties and decreased solubility of the prodrugs were observed as the side chain length increased. All esters showed conspicuous chemical stability in phosphate buffer (pH 7.4. Moreover, the enzymatic hydrolysis of esters in human plasma and human liver microsomes confirmed that the majority of esters were converted to LZDO, with release profiles that varied due to the size and structure of the side chain. In vivo pharmacokinetic studies following oral administration of monopivaloyl (M5, monodecyl (M10 and monododecyl (M12 esters demonstrated the evidently extended half-lives relative to LZDO dosed alone. In particular the monopivaloyl ester M5 exhibited an optimal pharmacokinetic profile with appropriate physiochemical characteristics.

  3. Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.

    Science.gov (United States)

    Vavříková, Eva; Langschwager, Fanny; Jezova-Kalachova, Lubica; Křenková, Alena; Mikulová, Barbora; Kuzma, Marek; Křen, Vladimír; Valentová, Kateřina

    2016-06-07

    A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside) esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C₅- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C₂), malonic (C₃), succinic (C₄) and maleic (C₄) acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin-Ciocalteau reagent (FCR) and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) than isoquercitrin; ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging activity was comparable. Dodecanoate and palmitate were the least active in FCR and ABTS scavenging; dodecanoate and hemiglutarate were the strongest DPPH scavengers. In contrast, most derivatives were much better inhibitors of microsomal lipoperoxidation than isoquercitrin; butyrate and hexanoate were the most efficient. Anti-lipoperoxidant activity of monocarboxylic derivatives, except acetates, decreased with increasing aliphatic chain. The opposite trend was noted for dicarboxylic acid hemiesters, isoquercitrin hemidodecanedioate being the most active. Overall, IQ butyrate, hexanoate and hemidodecanedioate are the most promising candidates for further studies.

  4. Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties

    Directory of Open Access Journals (Sweden)

    Eva Vavříková

    2016-06-01

    Full Text Available A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica, which accepted C5- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C2, malonic (C3, succinic (C4 and maleic (C4 acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin–Ciocalteau reagent (FCR and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl than isoquercitrin; ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid radical-scavenging activity was comparable. Dodecanoate and palmitate were the least active in FCR and ABTS scavenging; dodecanoate and hemiglutarate were the strongest DPPH scavengers. In contrast, most derivatives were much better inhibitors of microsomal lipoperoxidation than isoquercitrin; butyrate and hexanoate were the most efficient. Anti-lipoperoxidant activity of monocarboxylic derivatives, except acetates, decreased with increasing aliphatic chain. The opposite trend was noted for dicarboxylic acid hemiesters, isoquercitrin hemidodecanedioate being the most active. Overall, IQ butyrate, hexanoate and hemidodecanedioate are the most promising candidates for further studies.

  5. IMMUNOHISTOCHEMICAL ANALYSIS OF CASPASE-3 ACTIVITY IN LIVER BIOPSIES OF PATIENTS WITH MONO AND MIXED INFECTIONS

    Directory of Open Access Journals (Sweden)

    I. I. Tokin

    2015-01-01

    Full Text Available Objective: to study the activity of proapoptotic signal protein caspase-3 for determination of peculiarities of apoptosis regulation under liver chronic diseases.Subjects and methods. The immunohistochemical analysis of caspase-3 activity in 5 liver biopsies of the patients with mono infection of chronic hepatitis B and 5 liver biopsies of the patients with mixed infection of tuberculosis, chronic hepatitis C and human immunodeficiency virus was fulfilled. Morphological and morphometric analysis of serial microphotographs was performed using an image analysis system (microscope Leica DM 2500, digital camera Leica DFC320 R2 and a computer.Results. The activity of caspase-3 as dark brown granularity was revealed in all tis-sue components of liver (hepatocytes, epithelium of bile ducts, endotheliocytes, Kupffer cells of sinusoids, in compositions of lymphohistiocyte infiltrations. The maximal activity was discovered in hepatocytes nuclei. The expression of caspase-3 was significantly higher in liver biopsies of the patients with mixed infection. It is typical that the immunoreactive hepatocytes had not any morphological marks of apoptosis.Conclusion. The caspase-3 expression of proapoptotic signal protein caspase-3 may serve as an early marker of liver damage including the possibilities of apoptosis development.

  6. Overview of Mono-Energetic Gamma-Ray Sources and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hartemann, Fred; /LLNL, Livermore; Albert, Felicie; /LLNL, Livermore; Anderson, Scott; /LLNL, Livermore; Barty, Christopher; /LLNL, Livermore; Bayramian, Andy; /LLNL, Livermore; Chu, Tak Sum; /LLNL, Livermore; Cross, R.; /LLNL, Livermore; Ebbers, Chris; /LLNL, Livermore; Gibson, David; /LLNL, Livermore; Marsh, Roark; /LLNL, Livermore; McNabb, Dennis; /LLNL, Livermore; Messerly, Michael; /LLNL, Livermore; Shverdin, Miroslav; /LLNL, Livermore; Siders, Craig; /LLNL, Livermore; Jongewaard, Erik; /SLAC; Raubenheimer, Tor; /SLAC; Tantawi, Sami; /SLAC; Vlieks, Arnold; /SLAC; Semenov, Vladimir; /UC, Berkeley

    2012-06-25

    Recent progress in accelerator physics and laser technology have enabled the development of a new class of tunable gamma-ray light sources based on Compton scattering between a high-brightness, relativistic electron beam and a high intensity laser pulse produced via chirped-pulse amplification (CPA). A precision, tunable Mono-Energetic Gamma-ray (MEGa-ray) source driven by a compact, high-gradient X-band linac is currently under development and construction at LLNL. High-brightness, relativistic electron bunches produced by an X-band linac designed in collaboration with SLAC NAL will interact with a Joule-class, 10 ps, diode-pumped CPA laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. This MEGaray source will be used to excite nuclear resonance fluorescence in various isotopes. Applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. The source design, key parameters, and current status are presented, along with important applications, including nuclear resonance fluorescence.

  7. Sustainable design for environment-friendly mono and dicationic cholinium-based ionic liquids.

    Science.gov (United States)

    E Silva, Francisca A; Siopa, Filipa; Figueiredo, Bruna F H T; Gonçalves, Ana M M; Pereira, Joana L; Gonçalves, Fernando; Coutinho, João A P; Afonso, Carlos A M; Ventura, Sónia P M

    2014-10-01

    Cholinium-based ionic liquids are receiving crescent interest in diverse areas of application given their biological compatibility and potential for industrial application. In this work, mono and dicationic cholinium ionic liquids as well as cholinium derivatives were synthesized and their toxicity assessed using the luminescent bacteria Vibrio fischeri. A range of cholinium derivatives was synthesized, using different amines and the correspondent brominated derivatives, through the alkylation of the amine with the halide in MeCN. The results indicate that their toxicity is highly dependent on the structural modifications of the cholinium cation, mainly related to the alkyl side or linkage chain length, number of hydroxyethyl groups and insertion of carbon-carbon multiple bonds. The data indicated that it is possible to perform environmentally advantageous structural alterations, namely the addition of double bonds, which would not negatively affect V. fischeri. Moreover, the dicationic compounds revealed a significantly lower toxicity than the monocationic counterparts. The picture emerging from the results supports the idea that cholinium derivatives are promising ionic liquids with a low environmental impact, emphasizing the importance of a careful and directed design of ionic liquid structures.

  8. Specific fluorescent detection of fibrillar alpha-synuclein using mono- and trimethine cyanine dyes.

    Science.gov (United States)

    Volkova, K D; Kovalska, V B; Balanda, A O; Losytskyy, M Yu; Golub, A G; Vermeij, R J; Subramaniam, V; Tolmachev, O I; Yarmoluk, S M

    2008-02-01

    With the aim of searching of novel amyloid-specific fluorescent probes the ability of series of mono- and trimethine cyanines based on benzothiazole, pyridine and quinoline heterocycle end groups to recognize fibrillar formations of alpha-synuclein (ASN) was studied. For the first time it was revealed that monomethine cyanines can specifically increase their fluorescence in aggregated ASN presence. Dialkylamino-substituted monomethine cyanine T-284 and meso-ethyl-substituted trimethine cyanine SH-516 demonstrated the higher emission intensity and selectivity to aggregated ASN than classic amyloid stain Thioflavin T, and could be proposed as novel efficient fluorescent probes for fibrillar ASN detection. Studies of structure-function dependences have shown that incorporation of amino- or diethylamino- substituents into the 6-position of the benzothiazole heterocycle yields in a appearance of a selective fluorescent response to fibrillar alpha-synuclein presence. Performed calculations of molecular dimensions of studied cyanine dyes gave us the possibility to presume, that dyes bind with their long axes parallel to the fibril axis via insertion into the neat rows (so called 'channels') running along fibril.

  9. Mono- and Dinuclear Macrocyclic Calcium Complexes as Platforms for Mixed-Metal Complexes and Clusters.

    Science.gov (United States)

    Connolly, Emma A; Leeland, James W; Love, Jason B

    2016-01-19

    Mono- and dinuclear calcium complexes of the Schiff-base macrocycles H4L have been prepared and characterized spectroscopically and crystallographically. In the formation of Ca(THF)2(H2L(1)), Ca2(THF)2(μ-THF)(L(1)), and Ca2(THF)4(L(2)), the ligand framework adopts a bowl-shaped conformation instead of the conventional wedge, Pacman-shaped structure as seen with the anthracenyl-hinged complex Ca2(py)5(L(3)). The mononuclear calcium complex Ca(THF)2(H2L(1)) reacts with various equivalents of LiN(SiMe3)2 to form calcium/alkali metal clusters and dinuclear transition metal complexes when reacted subsequently with transition metal salts. The dinuclear calcium complex Ca2(THF)2(μ-THF)(L(1)), when reacted with various equivalents of NaOH, is shown to act as a platform for the formation of calcium/alkali metal hydroxide clusters, displaying alternate wedged and bowl-shaped conformations.

  10. Chiral separation of benzoporphyrin derivative mono- and diacids by laser induced fluorescence-capillary electrophoresis.

    Science.gov (United States)

    Peng, Xuejun; Sternberg, Ethan; Dolphin, David

    2002-01-01

    A method for the separation of benzoporphyrin derivative mono- and diacid (BPDMA, BPDDA) enantiomers by laser induced fluorescence-capillary electrophoresis (LIF-CE) has been developed. By using 300 mM borate buffer, pH 9.2, 25 mM sodium cholate and 10% acetronitrile as electrolyte, +10 kV electrokinetic sampling injection of 2 s and an applied +20 kV voltage across the ends of a 37 cm capillary (30 cm to the detector, 50 microm ID), all six BPD stereoisomers were baseline-separated within 20 min. Formation constants, free electrophoretic and complexation mobilities with borate and cholate were determined based on dynamic complexation capillary electrophoresis theory. The BPD enantiomers can be quantitatively determined in the range of 10(-2)-10(-5) mg mL(-1). The correlation coefficients (r2) of the least-squares linear regression analysis of the BPD enantiomers are in the range of 0.9914-0.9997. Their limits of detection are 2.18-3.5 x 10(-3) mg mL(-1). The relative standard deviations for the separation were 2.90-4.64% (n = 10). In comparison with high-performance liquid chromatography (HPLC), CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.

  11. Studies on the mammary tumor-inhibiting effects of diethylstilbestrol and its mono- and diphosphate.

    Science.gov (United States)

    Schneider, M R; von Angerer, E; Prekajac, J; Brade, W P

    1986-01-01

    Diethylstilbestrol (DES), diethylstilbestrol monophosphate (DES-MP) and diethylstilbestrol diphosphate (DES-DP) were tested for their estrogen receptor affinity, estrogenic potency and mammary tumor-inhibiting activity in vitro and in vivo. DES had a much higher receptor binding affinity than its mono- or diphosphate. All three compounds inhibited the growth of the hormone-dependent MCF-7 and hormone-independent MDA-MB 231 breast cancer line only at relatively high concentrations. The estrogenic potency in the immature mouse uterine weight test decreased in the order DES greater than DES-MP much greater than DES-DP. The hormone-dependent MXT mammary tumor of the mouse was inhibited by all three compounds at a dosage of 1.0 mg/kg per week. At a dose of 0.01 mg/kg, DES, DES-MP, and DES-DP stimulated the tumor growth. Thus, for the first time, a biphasic effect on tumor growth was demonstrated in intact mature animals. As the effects of all three compounds were similar in this assay, a cleavage of the phosphate groups is likely. A decrease in estrogenic potency concomitant with a retained antitumor effect of DES-MP and DES-DP compared to DES was not demonstrable in the mature mouse using the MXT assay, only in the uterotrophic test in the immature mouse.

  12. Priority-Based-Budgeting: A Debacle in a Mono – Cultural Economy

    Directory of Open Access Journals (Sweden)

    Omah I.

    2013-04-01

    Full Text Available The contention of this paper is to highlight the difficulties in implementation of priority-based-budgeting in a mono-cultural economies of the third world countries. To device a means by which the budgetary system could be applied meaningfully and advantageously, linking the conventional/traditional methodology to the neo-supra system. To highlight outstanding advantages of priority-based-budgeting, when cautiously applied and strictly adhered by its norms. It is a neolithic advent of budgeting implementation. Priority-based-budgeting is a non-conventional budgetary implementation, hence, its data collection is marred by myopic tendency of the budget segment of the concerned organization. Data procurement has been a stumbling block due to unfamiliarity of the system to the public sector as well as private segment of the economy. A structured questionnaire was adopted to harness the concept of priority-based-budgeting as a focus to the respondents. Online discussions were carried out on a lesser scale particularly with the closely affiliated individuals in some subsections of the government and organizations as a whole. Many key-stakeholders in private institutions were highly fascinated with the concept and were wiling to furnish their available information regarding the progress of the investigation.

  13. The Santa Cruz - Tarija Province of Central South America: Los Monos - Machareti(!) Petroleum System

    Science.gov (United States)

    Lindquist, Sandra J.

    1999-01-01

    The Los Monos - Machareti(!) total petroleum system is in the Santa Cruz - Tarija Province of Bolivia, Argentina and Paraguay. Province history is that of a Paleozoic, intracratonic, siliciclastic rift basin that evolved into a Miocene (Andean) foreland fold and thrust belt. Existing fields are typified by alternating reservoir and seal rocks in post-Ordovician sandstones and shales on anticlines. Thick Devonian and Silurian shale source rocks, depositionally and erosionally confined to this province, at a minimum have generated 4.1 BBOE known ultimate recoverable reserves (as of 1995, 77% gas, 15% condensate, 8% oil) into dominantly Carboniferous reservoirs with average 20% porosity and 156 md permeability. Major detachment surfaces within the source rocks contributed to the thin-skinned and laterally continuous nature of the deformation. Tertiary foreland burial adequate for significant source maturation coincided with the formation of compressional traps. Further hydrocarbon discovery in the fold and thrust belt is expected. In the foreland basin, higher thermal gradients and variable burial history - combined with the presence of unconformity and onlap wedges - create potential there for stratigraphic traps and pre-Andean, block-fault and forced-fold traps.

  14. Inkjet Printing Based Mono-layered Photonic Crystal Patterning for Anti-counterfeiting Structural Colors

    Science.gov (United States)

    Nam, Hyunmoon; Song, Kyungjun; Ha, Dogyeong; Kim, Taesung

    2016-08-01

    Photonic crystal structures can be created to manipulate electromagnetic waves so that many studies have focused on designing photonic band-gaps for various applications including sensors, LEDs, lasers, and optical fibers. Here, we show that mono-layered, self-assembled photonic crystals (SAPCs) fabricated by using an inkjet printer exhibit extremely weak structural colors and multiple colorful holograms so that they can be utilized in anti-counterfeit measures. We demonstrate that SAPC patterns on a white background are covert under daylight, such that pattern detection can be avoided, but they become overt in a simple manner under strong illumination with smartphone flash light and/or on a black background, showing remarkable potential for anti-counterfeit techniques. Besides, we demonstrate that SAPCs yield different RGB histograms that depend on viewing angles and pattern densities, thus enhancing their cryptographic capabilities. Hence, the structural colorations designed by inkjet printers would not only produce optical holograms for the simple authentication of many items and products but also enable a high-secure anti-counterfeit technique.

  15. Mixtures of mono-, di- and tri-glycerides as energy supplements to broilers’ diets

    Directory of Open Access Journals (Sweden)

    Sara Minieri

    2010-01-01

    Full Text Available Mixtures of mono-, di- and tri-glycerides from olive oil (MDT were added to: palm oil (PO, olive oil (OO, soybean oil (SO, free fatty acids from palm oil (PFA, free fatty acids from olive oil (OFA. The compound mixtures were used as energy supplements in the diets of broiler chickens in comparison with plain SO and plain animal fat (AF. Two hundred and ten birds were randomly allotted to 7 dietary treatments with the diverse oil sources: 6 birds per cage, 5 cages per treatment. The effects of the treatments on growth rates, feed/gain ratios and acidic composition of abdominal fat of hybrid Ross 308 female chickens were studied. The animals were slaughtered at the end of the trial, at day 35. The breast meat quality was then evaluated by a panel of 15 trained members and analysed for shelf life duration. The AF treat- ment gave the highest weight gain, but only in the first week. MDT + OO (50/50 resulted the best combination, with slight, non significant, better performances and a decidedly better quality in terms of acidic composition of abdominal fat, taste and juiciness of breast meat and shelf life.

  16. Mono-(2-Ethylhexyl Phthalate Promotes Pro-Labor Gene Expression in the Human Placenta.

    Directory of Open Access Journals (Sweden)

    Ximi K Wang

    Full Text Available Women exposed to phthalates during pregnancy are at increased risk for delivering preterm, but the mechanism behind this relationship is unknown. Placental corticotropin-releasing hormone (CRH and cyclooxygenase-2 (COX-2 are key mediators of parturition and are regulated by the non-canonical NF-kB (RelB/p52 signaling pathway. In this study, we demonstrate that one of the major phthalate metabolites, mono-(2-ethylhexyl-phthalate (MEHP, increased CRH and COX-2 mRNA and protein abundance in a dose-dependent manner in primary cultures of cytotrophoblast. This was coupled with an increase in nuclear import of RelB/p52 and its association with the CRH and COX-2 promoters. Silencing of NF-kB inducing kinase, a central signaling component of the non-canonical NF-kB pathway, blocked MEHP-induced upregulation of CRH and COX-2. These results suggest a potential mechanism mediated by RelB/p52 by which phthalates could prematurely induce pro-labor gene activity and lead to preterm birth.

  17. Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis

    Directory of Open Access Journals (Sweden)

    Ting-Yi Chien

    2016-02-01

    Full Text Available The fresh rhizome of Zingiber zerumbet Smith (Zingiberaceae is used as a food flavoring and also serves as a folk medicine as an antipyretic and for analgesics in Taiwan. Zerumbone, a monocyclic sesquiterpene was isolated from the rhizome of Z. zerumbet and is the major active compound. In this study, the anti-inflammatory and antinociceptive effects of zerumbone on arthritis were explored using in vitro and in vivo models. Results showed that zerumbone inhibited inducible nitric oxide (NO synthase (iNOS, cyclooxygenase (COX-2 expressions, and NO and prostaglandin E2 (PGE2 production, but induced heme oxygenase (HO-1 expression in a dose-dependent manner in lipopolysaccharide (LPS-stimulated RAW 264.7 cells. When zerumbone was co-treated with an HO-1 inhibitor (tin protoporphyrin (SnPP, the NO inhibitory effects of zerumbone were recovered. The above results suggest that zerumbone inhibited iNOS and COX-2 through induction of the HO-1 pathway. Moreover, matrix metalloproteinase (MMP-13 and COX-2 expressions of interleukin (IL-1β-stimulated primary rat chondrocytes were inhibited by zerumbone. In an in vivo assay, an acetic acid-induced writhing response in mice was significantly reduced by treatment with zerumbone. Furthermore, zerumbone reduced paw edema and the pain response in a mono-iodoacetate (MIA-induced rat osteoarthritis model. Therefore, we suggest that zerumbone possesses anti-inflammatory and antinociceptive effects which indicate zerumbone could be a potential candidate for osteoarthritis treatment.

  18. Mineral resource potential map of the John Muir Wilderness, Fresno, Inyo, Madera, and Mono counties, California

    Science.gov (United States)

    Du Bray, E.A.; Dellinger, D.A.; Diggles, M.F.; Oliver, H.W.; Johnson, F.L.; Thurber, H.K.; Morris, R.W.; Perers, T.J.; Lindsey, D.S.

    1982-01-01

    Under the provisions of the Wilderness Act (Public Law 88-577, September 3, 1964) and the Joint Conference Report on Senate Bill 4, 88th Congress, the U.S. Geological Survey and the U.S. Bureau of Mines have been conducting mineral surveys of wilderness and primitive areas. Areas officially designated as "wilderness," "wild," or "canoe" when the act was passed were incorporated into the National Wilderness Preservation System, and some of them are presently being studied. The act provided that areas under consideration for wilderness designation should be studied for suitability for incorporation into the Wilderness System. The mineral surveys constitute one aspect of the suitability studies. The act directs that the results of such surveys are to be made available to the public and be submitted to the President and the Congress. This report discusses the results of a mineral survey of the John Muir Wilderness, Inyo and Sierra National Forests, Fresno, lnyo, Madera, and Mono Counties, California. The area was established as a wilderness by Public Law 88-577, September 3, 1964.

  19. Mineralization of mono-nitrophenols by Bjerkandera adusta and Lentinus squarrosulus and their extracellular ligninolytic enzymes.

    Science.gov (United States)

    Tripathi, Astha; Upadhyay, R C; Singh, Surendra

    2011-12-01

    Nitroaromatic compounds constitute a major class of widely distributed environmental contaminants. Fifty fungal strains were screened for their potential to tolerance with 2-nitrophenol, 3-nitrophenol and 4-nitrophenol on solid medium supplemented with 2% malt extract (MEA). Growth rate (mm/day) was determined at three concentrations (0.25, 0.5 and 1 mM) of all the three nitrophenols. From the fifty fungal strains only Bjerkandera adusta and Lentinus squarrosulus were able to tolerate all the three nitrophenols (NPs). These white-rot fungi (WRF) were chosen for liquid medium studies for the mineralization of mono-nitrophenols and ligninolytic enzyme activity at 0.25 mM concentration. Both varieties completely removed 2-NP and 3-NP while 4-NP was hard to mineralize. AAO (Aryl Alcohol Oxidase) is the main oxidase enzyme in B. adusta while laccase plays important role in L. squarrosulus. MnP (Manganese peroxidase) is the main peroxidase enzyme in both varieties. These fungal strains were capable to degrade nitrophenols and could be used for bioremediation applications on large scale.

  20. Contribution of mono and polysaccharides to heterotrophic N2 fixation at the eastern Mediterranean coastline.

    Science.gov (United States)

    Rahav, E; Giannetto, M J; Bar-Zeev, E

    2016-06-16

    N2 fixation should be a critical process in the nitrogen-poor surface water of the eastern Mediterranean Sea. Despite favorable conditions, diazotroph abundance and N2 fixation rates remains low for reasons yet explained. The main goal of this study was to investigate the limiting nutrients for diazotrophy in this oligotrophic environment. Hence, we conducted dedicated bottle-microcosms with eastern Mediterranean Sea water that were supplemented with mono and polysaccharides as well as inorganic nitrogen and phosphorous. Our results indicate that the diazotrophic community expressing nifH was primarily represented by heterotrophic Proteobacteria. N2 fixation and heterotrophic bacterial activity increased up-to tenfold following two days of dark incubations, once seawater was supplemented with organic carbon substrate in the form of glucose (monosaccharides) or gum-xanthan (polysaccharide surrogate). Furthermore, our results point that carbon-rich polysaccharides, such as transparent exopolymer particles, enhance heterotrophic N2 fixation, by forming microenvironments of intense metabolic activity, high carbon: nitrogen ratio, and possibly low O2 levels. The conclusions of this study indicate that diazotrophs in the eastern Mediterranean coast are primarily limited by organic carbon substrates, as possibly in many other marine regions.

  1. Substituent effects in the 13C NMR chemical shifts of alpha-mono-substituted acetonitriles.

    Science.gov (United States)

    Reis, Adriana K C A; Rittner, Roberto

    2007-03-01

    13C chemical shifts empirical calculations, through a very simple additivity relationship, for the alpha-methylene carbon of some alpha-mono-substituted acetonitriles, Y-CH(2)-CN (Y=H, F, Cl, Br, I, OMe, OEt, SMe, SEt, NMe(2), NEt(2), Me and Et), lead to similar, or even better, results in comparison to the reported values obtained through Quantum Mechanics methods. The observed deviations, for some substituents, are very similar for both approaches. This divergence between experimental and calculated, either empirically or theoretically, values are smaller than for the corresponding acetones, amides, acetic acids and methyl esters, which had been named non-additivity effects (or intramolecular interaction chemical shifts, ICS) and attributed to some orbital interactions. Here, these orbital interactions do not seem to be the main reason for the non-additivity effects in the empirical calculations, which must be due solely to the magnetic anisotropy of the heavy atom present in the substituent. These deviations, which were also observed in the theoretical calculations, were attributed in that case to the non-inclusion of relativistic effects and spin-orbit coupling in the Hamiltonian. Some divergence is also observed for the cyano carbon chemical shifts, probably due to the same reasons.

  2. Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis.

    Science.gov (United States)

    Chien, Ting-Yi; Huang, Steven Kuan-Hua; Lee, Chia-Jung; Tsai, Po-Wei; Wang, Ching-Chiung

    2016-02-18

    The fresh rhizome of Zingiber zerumbet Smith (Zingiberaceae) is used as a food flavoring and also serves as a folk medicine as an antipyretic and for analgesics in Taiwan. Zerumbone, a monocyclic sesquiterpene was isolated from the rhizome of Z. zerumbet and is the major active compound. In this study, the anti-inflammatory and antinociceptive effects of zerumbone on arthritis were explored using in vitro and in vivo models. Results showed that zerumbone inhibited inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase (COX)-2 expressions, and NO and prostaglandin E₂ (PGE₂) production, but induced heme oxygenase (HO)-1 expression in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. When zerumbone was co-treated with an HO-1 inhibitor (tin protoporphyrin (SnPP)), the NO inhibitory effects of zerumbone were recovered. The above results suggest that zerumbone inhibited iNOS and COX-2 through induction of the HO-1 pathway. Moreover, matrix metalloproteinase (MMP)-13 and COX-2 expressions of interleukin (IL)-1β-stimulated primary rat chondrocytes were inhibited by zerumbone. In an in vivo assay, an acetic acid-induced writhing response in mice was significantly reduced by treatment with zerumbone. Furthermore, zerumbone reduced paw edema and the pain response in a mono-iodoacetate (MIA)-induced rat osteoarthritis model. Therefore, we suggest that zerumbone possesses anti-inflammatory and antinociceptive effects which indicate zerumbone could be a potential candidate for osteoarthritis treatment.

  3. Nickel Electroless Plating: Adhesion Analysis for Mono-Type Crystalline Silicon Solar Cells.

    Science.gov (United States)

    Shin, Eun Gu; Rehman, Atteq ur; Lee, Sang Hee; Lee, Soo Hong

    2015-10-01

    The adhesion of the front electrodes to silicon substrate is the most important parameters to be optimized. Nickel silicide which is formed by sintering process using a silicon substrate improves the mechanical and electrical properties as well as act as diffusion barrier for copper. In this experiment p-type mono-crystalline czochralski (CZ) silicon wafers having resistivity of 1.5 Ω·cm were used to study one step and two step nickel electroless plating process. POCl3 diffusion process was performed to form the emitter with the sheet resistance of 70 ohm/sq. The Six, layer was set down as an antireflection coating (ARC) layer at emitter surface by plasma enhanced chemical vapor deposition (PECVD) process. Laser ablation process was used to open SiNx passivation layer locally for the formation of the front electrodes. Nickel was deposited by electroless plating process by one step and two step nickel electroless deposition process. The two step nickel plating was performed by applying a second nickel deposition step subsequent to the first sintering process. Furthermore, the adhesion analysis for both one step and two steps process was conducted using peel force tester (universal testing machine, H5KT) after depositing Cu contact by light induced plating (LIP).

  4. A mono-dimensional nuclear fuel performance analysis code, PUMA, development from a coupled approach

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, J. S.; Lee, B. O.; Lee, C. B. [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseong, Daejeon, 305-353 (Korea, Republic of); Yacout, A. M. [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)

    2013-07-01

    Multidimensional-multi-physical phenomena in nuclear fuels are treated as a set of mono-dimensional-coupled problems which encompass heat, displacement, fuel constituent redistribution, and fission gas release. Rather than uncoupling these coupled equations as in conventional fuel performance analysis codes, efforts are put into to obtain fully coupled solutions by relying on the recent advances of numerical analysis. Through this approach, a new SFR metal fuel performance analysis code, called PUMA (Performance of Uranium Metal fuel rod Analysis code) is under development. Although coupling between temperature and fuel constituent was made easily, the coupling between the mechanical equilibrium equation and a set of stiff kinetics equations for fission gas release is accomplished by introducing one-level Newton scheme through backward differentiation formula. Displacement equations from 1D finite element formulation of the mechanical equilibrium equation are solved simultaneously with stress equation, creep equation, swelling equation, and FGR equations. Calculations was made successfully such that the swelling and the hydrostatic pressure are interrelated each other. (authors)

  5. The vertical motions of mono-abundance sub-populations in the Milky Way disk

    CERN Document Server

    Bovy, Jo; Hogg, David W; Beers, Timothy C; Lee, Young Sun; Zhang, Lan

    2012-01-01

    We present the vertical kinematics of stars in the Milky Way's stellar disk inferred from SDSS/SEGUE G-dwarf data, deriving the vertical velocity dispersion, \\sigma_z, as a function of vertical height |z| and Galactocentric radius R for a set of 'mono-abundance' sub-populations of stars with very similar elemental abundances [\\alpha/Fe] and [Fe/H]. We find that all components exhibit nearly isothermal kinematics in |z|, and a slow outward decrease of the vertical velocity dispersion: $\\sigma_z (z,R\\,|[\\alpha/Fe],[Fe/H]) ~ \\sigma_z ([\\alpha/Fe],[Fe/H]) x \\exp (-(R-R_0)/7 kpc})$. The characteristic velocity dispersions of these components vary from ~ 15 km/s for chemically young, metal-rich stars, to >~ 50 km/s for metal poor stars. The mean \\sigma_z gradient away from the mid plane is only 0.3 +/- 0.2 km/s/kpc. We find a continuum of vertical kinetic temperatures (~\\sigma^2_z) as function of ([\\alpha/Fe],[Fe/H]), which contribute to the stellar surface mass density as \\Sigma_{R_0}(\\sigma^2_z) ~ \\exp(-\\sigma^2_...

  6. Mono or 3D video production for scientific dissemination of nuclear energy applications

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Victor Goncalves G.; Mol, Antonio Carlos A.; Biermann, Bruna; Jorge, Carlos Alexandre F., E-mail: mol@ien.gov.b, E-mail: vgoncalves@ien.gov.b, E-mail: calexandre@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Araujo, Tawein [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola de Belas Artes; Legey, Ana Paula [Universidade Gama Filho (UGF), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

  7. Effects of mono- and disaccharides on the antimicrobial activity of bovine lactoperoxidase system.

    Science.gov (United States)

    Al-Baarri, Ahmad Nimatullah; Hayashi, Makoto; Ogawa, Masahiro; Hayakawa, Shigeru

    2011-01-01

    The effects of mono- and disaccharides on the antimicrobial activity of the lactoperoxidase (LPO) system against Salmonella Enteritidis were investigated. The results clearly reveal that most of the sugars inhibit the antimicrobial activity of the LPO system. The inhibitory potency varies depending on the structure of sugar. L-Fructose and D-allose were strongly inhibitive to the action of the LPO system, while sucrose was the weakest inhibitor. The decreased antimicrobial activity is due to the reduction of LPO catalytic activity by sugar. An inhibitory kinetic study showed the noncompetitive inhibitor. D-Allose and L-fructose yielded strikingly low K(i) values of 0.36 and 0.42 mM, respectively, while the K(i) values of the other sugars ranged from 1.37 to 3.60 mM. Since LPO activity is inhibited by the saccharides, the sugar content in food should be considered when the LPO system is applied to the preservation of food.

  8. Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.

    Science.gov (United States)

    Stevenson, Julian; Luu, Winnie; Kristiana, Ika; Brown, Andrew J

    2014-08-01

    SM (squalene mono-oxygenase) catalyses the first oxygenation step in cholesterol synthesis, immediately before the formation of the steroid backbone at lanosterol. SM is an important control point in the pathway, and is regulated at the post-translational level by accelerated cholesterol-dependent ubiquitination and proteasomal degradation, which is associated with the accumulation of squalene. Using model cell systems, we report that SM is stabilized by unsaturated fatty acids. Treatment with unsaturated fatty acids such as oleate, but not saturated fatty acids, increased protein levels of SM or SM-N100-GFP (the first 100 amino acids of SM fused to GFP) at the post-translational level and partially overcame cholesterol-dependent degradation, as well as reversing cholesterol-dependent squalene accumulation. Maximum stabilization required activation of fatty acids, but not triacylglycerol or phosphatidylcholine synthesis. The mechanism of oleate-mediated stabilization appeared to occur through reduced ubiquitination by the E3 ubiquitin ligase MARCH6. Stabilization of a cholesterol biosynthetic enzyme by unsaturated fatty acids may help maintain a constant cholesterol/phospholipid ratio.

  9. Numerical Study of Injection Mechanisms for Generation of Mono-Energetic Femtosecond Electron Bunch from the Plasma Cathode

    CERN Document Server

    Ohkubo, Takeru; Zhidkov, Alexei

    2005-01-01

    Acceleration gradients of up to the order of 100GV/m and mono-energetic electron bunch up to 200MeV have recently been observed in several plasma cathode experiments. However, mechanisms of self-injection in plasma are not sufficiently clarified, presently. In this study, we carried out 2D PIC simulation to reveal the mechanisms of mono-energetic femtosecond electron bunch generation. We found two remarkable conditions for the generation: electron density gradient at vacuum-plasma interface and channel formation in plasma. Steep electron density gradient (~ plasma wave length) causes rapid injection and produces an electron bunch with rather high charge and less than 100fs duration. The channel formation guides an injected laser pulse and decreases the threshold of laser self-focusing, which leads to high electric field necessary for wave-breaking injection.

  10. Hydrolysis of p-Nitrophenyl Picolinate Catalyzed by Mono-and Binuclear Transition Metal Complexes with Polyether Bridged Dihydroxamic Acid

    Institute of Scientific and Technical Information of China (English)

    李建章; 李鸿波; 冯发美; 谢家庆; 李慎新; 周波; 秦圣英

    2005-01-01

    Two polyether bridged dihydroxamic acids and their mono-and binuclear manganese(Ⅱ), zinc(Ⅱ) complexes have been synthesized and employed as models to mimic hydrolase in catalytic hydrolysis of p-nitrophenyl picolinate (PNPP). The reaction kinetics and the mechanism of hydrolysis of PNPP have been investigated. The kinetic mathematical model for PNPP cleaved by the complexes has been proposed. The effects of the different central metal ion, mono-and binuclear metal, the pseudo-macrocyclic polyether constructed by polyethoxy group of the complexes, and reactive temperature on the rate for catalytic hydrolysis of PNPP have been examined. The results showed that the transition metal dthydroxamates exhibited high catalytic activity to the hydrolysis of PNPP, the catalytic activity of binuclear complexes was higher than that of mononuclear ones, and the pseudo-macrocyclic polyether might synergetically activate H20 coordinated to metal ion with central metal ion together and promote the catalytic hydrolysis of PNPP.

  11. Reliability design of mono-leaf spring for front-axle suspension of large-sized trucks

    Energy Technology Data Exchange (ETDEWEB)

    Savaidis, G. [Aristotle Univ. of Thessaloniki, Dept. of Mechanical Engineering (Greece); Schwaiger, F. [MAN Nutzfahrzeuge AG, Munich (Germany); Momiyama, F.; Yamazumi, T.; Muramatsu, K. [Horikiri Inc., Chiba-Pref. (Japan)

    2004-07-01

    This paper deals with the development of a fatigue-accurate suspension system for large-sized trucks based on mono-leaf steel springs, It shows the fulfillment of the demands for lightweight construction, sufficient fatigue life and fail-safe behaviour. The paper contains the fatigue load assumptions used for the non-linear finite-element stress-strain analysis, the experimental verification by means of measured load, stress and strain data determined by driving quasi-static manoeuvres and over various rough road segments with a prototype vehicle, as well as the experimental uniaxial and multiaxial fatigue tests required for the durability approval. The fatigue lives achieved, confirm the adequate service life of the developed spring. In addition, appropriate vehicle tests on a test track with a custom-made mono-leaf spring system confirmed the fail-safe design of the suspension system. (orig.)

  12. Fabrication of a Mono-Domain Alignment Ferroelectric Liquid Crystal Device Using a Polar Self-Assembled Monolayer

    Institute of Scientific and Technical Information of China (English)

    ZOU Zhong-Fei; YAO Li-Shuang; TANG Xian-Zhu; JI Xin-Jian; XUAN Li

    2008-01-01

    A mono-domain ferroelectric liquid crystal device (FLCD) is fabricated using a novel method. The cell used in this method is an asymmetric cell, typically the combination of a polar self-assembled monolayer (SAM) for one substrate and a rubbed polyimide for the other substrate. A defect-free alignment of ferroelectric liquid crystal is fabricated without applying a dc voltage to remove degeneracy in the layer structure. The contact angles of self-assembled monolayer and PI-2942 are measured and the polarity of SAM is higher than the PI alignment. It is found that the polarity of self-assembled monolayer is a key factor in the formation of mono-domain alignment of FLC.

  13. Search for Mono-Higgs Signals at the LHC in the B-L Supersymmetric Standard Model

    CERN Document Server

    Abdallah, W; Khalil, S; Moretti, S

    2016-01-01

    We study mono-Higgs signatures emerging in the $B-L$ supersymmetric standard model induced by new channels not present in the minimal supersymmetric standard model, i.e., via topologies in which the mediator is either a heavy $Z'$, with mass of ${\\cal O}(2~{\\rm TeV})$, or an intermediate $h'$ (the lightest CP-even Higgs state of $B-L$ origin), with mass of ${\\cal O}(0.2~{\\rm TeV})$. The mono-Higgs probe considered is the SM-like Higgs state recently discovered at the large hadron collider, so as to enforce its mass reconstruction for background reduction purposes. With this in mind, its two cleanest signatures are selected: $\\gamma\\gamma$ and $ZZ^*\\to 4l$ ($l=e,~\\mu$). We show how both of these can be accessed with foreseen energy and luminosity options using a dedicated kinematic analysis performed in presence of partonic, showering, hadronisation and detector effects.

  14. A putative flavin-containing mono-oxygenase as a marker for certain defense and cell death pathways

    DEFF Research Database (Denmark)

    Olszak, Brian; Malinovsky, Frederikke Gro; Brodersen, Peter

    2006-01-01

    mRNA of the putative Arabidopsis flavin mono-oxygenase encoded by At1g19250 (here designated AtFMO GenBank accession no. NM_101783 ) accumulated to high levels in the acd11 and lsd1 mutants that exhibit run-away cell death, but not in mutants with constitutive defense responses. AtFMO mRNA accumu......mRNA of the putative Arabidopsis flavin mono-oxygenase encoded by At1g19250 (here designated AtFMO GenBank accession no. NM_101783 ) accumulated to high levels in the acd11 and lsd1 mutants that exhibit run-away cell death, but not in mutants with constitutive defense responses. AtFMO m...

  15. The impact of Ni, Co and Mo supplementation on methane yield from anaerobic mono-digestion of maize silage.

    Science.gov (United States)

    Evranos, Beyza; Demirel, Burak

    2015-01-01

    The objective of this experimental study was to demonstrate the impact of trace metal supplementation, namely nickel (Ni), cobalt (Co) and molybdenum (Mo), on the methane yields obtained from batch mesophilic anaerobic digestion of maize silage as mono-substrate. The maize silage used in this experimental work initially lacked Ni and Co. Trace metal concentration selected was 0.1 and 0.5 mg/L for Ni and Co, respectively, while it was 0.05 and 0.25 mg/L for Mo. The supplementation by Ni, Co and Mo, individually or in combination at different doses, seemed to improve the methane yields for mono-digestion of maize silage and particularly, the highest methane yield of 0.429 L CH4/g VSadded was obtained, when Ni, Co and Mo were supplemented together at concentrations of 0.5, 0.5 and 0.25 mg/L, respectively.

  16. Interaction of Hypocrellin B or Mono-cysteine Substituted Hypocrellin B with CT-DNA by Spectral Methods

    Institute of Scientific and Technical Information of China (English)

    Jia Hong ZHOU; Sheng Qin XIA; Xue Song WANG; Bao Wen ZHANG; Yi CAO

    2003-01-01

    The interaction of the anticancer drag hypocrellin B (HB) or the mono-cysteinesubstituted hypocrellin B (MCHB) and calf thymus deoxyribonucleic acid (CT-DNA) has beeninvestigated using spectral methods. The results of UV-visible spectra show that the HB andMCHB could intercalate into the base-stacking domain of the CT-DNA double helix. The studiesof fluorescence spectra and circular dichroism(CD) spectra also support the interacalationmechanism.

  17. Ceric Ion Loaded MCM-41 Catalyzed Synthesis of Substituted Mono- and Bis-dihydropyrimidin-2(1H-ones

    Directory of Open Access Journals (Sweden)

    Pullar Vadivel

    2013-01-01

    Full Text Available An effective one-pot three-component reaction of aromatic aldehydes with 1,3-diketone and urea or thiourea under solvent-free condition leads to the formation of mono- and bis-dihydropyrimidin-2-(1H-ones using Ce-MCM-41 as a recyclable solid acid catalyst. This method has several advantages like simple and easy work-up with shorter reaction time, reusability of catalyst, and high yields of Biginelli products.

  18. Metabolism of mono- and dihalogenated C1 and C2 compounds by Xanthobacter autotrophicus growing on 1,2-dichloroethane

    OpenAIRE

    Torz, Maciej; Wietzes, Piet; Beschkov, Venko; Janssen, Dick B.

    2007-01-01

    The conversion of and toxic effects exerted by several mono- and dihalogenated C1 and C2 compounds on cultures of Xanthobacter autotrophicus GJ10 growing on 1,2-dichloroethane were investigated. Bromochloromethane, dibromomethane and 1-bromo-2-chloroethane were utilized by strain GJ10 in batch culture as a cosubstrate and sole carbon source. The rate of degradation of dihalomethanes by whole cells was lower than that of 1,2-dichloroethane, but a significant increase of the rate of dihalometha...

  19. Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata).

    Science.gov (United States)

    Sun, Shi; Liu, Jingchun; Kadouh, Hoda; Sun, Xiuxiu; Zhou, Kequan

    2014-06-15

    Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and HPLC purification. These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells.

  20. Metal–Organic Frameworks Stabilize Mono(phosphine)–Metal Complexes for Broad-Scope Catalytic Reactions

    Energy Technology Data Exchange (ETDEWEB)

    Sawano, Takahiro; Lin, Zekai; Boures, Dean; An, Bing; Wang, Cheng; Lin, Wenbin (UC); (Xiamen)

    2016-08-10

    Mono(phosphine)–M (M–PR3; M = Rh and Ir) complexes selectively prepared by postsynthetic metalation of a porous triarylphosphine-based metal–organic framework (MOF) exhibited excellent activity in the hydrosilylation of ketones and alkenes, the hydrogenation of alkenes, and the C–H borylation of arenes. The recyclable and reusable MOF catalysts significantly outperformed their homogeneous counterparts, presumably via stabilizing M–PR3 intermediates by preventing deleterious disproportionation reactions/ligand exchanges in the catalytic cycles.

  1. Noncatalytic mono-N-methylation of aniline in supercritical methanol: the kinetics and acid/base effect.

    Science.gov (United States)

    Takebayashi, Yoshihiro; Morita, Yoshinori; Sakai, Hideki; Abe, Masahiko; Yoda, Satoshi; Furuya, Takeshi; Sugeta, Tsutomu; Otake, Katsuto

    2005-08-21

    Aniline is easily N-methylated in supercritical methanol without catalyst at 350 degrees C and 0.237 g cm-3 to give mono-N-methylaniline with high selectivity, and the reaction rate is increased by a small amount of base (LiOH, NaOH, KOH, and CH3ONa), indicating a difference in the reaction mechanism from the ordinary acid-catalyzed one.

  2. N-terminal mono-PEGylation of growth hormone antagonist: correlation of PEG size and pharmacodynamic behavior.

    Science.gov (United States)

    Wu, Ling; Ho, Sa V; Wang, Wei; Gao, Jianping; Zhang, Guifeng; Su, Zhiguo; Hu, Tao

    2013-09-10

    Growth hormone antagonist (GHA), an analog of growth hormone (GH), can inhibit GH action and treat acromegaly. However, GHA suffers from a short plasma half-life of 15-20 min that has limited its clinical application. PEGylation, conjugation with polyethylene glycol (PEG), can increase the plasma half-life of GHA. Single PEG attachment (mono-PEGylation) at N-terminus of GHA has the advantages of product homogeneity and minimization of the bioactivity loss. Conjugation of large PEG molecule may increase the plasma half-life but could potentially decrease the bioactivity of GHA, due to the steric shielding effect of PEG. Thus, N-terminal mono-PEGylation of GHA with 20 kDa and 40 kDa PEG were used to look for a balance of the two competing factors. Sedimentation velocity analysis suggested that 40 kDa PEG was more efficient than 20 kDa PEG to elongate the molecular shape of the conjugate. As reflected by marginal suppression of insulin-like growth factor I (IGF-I), GHA conjugated with 40 kDa PEG was statistically indistinguishable from the saline solution that could not inhibit GH action. In contrast, GHA conjugated with 20kDa PEG can apparently inhibit GH action, as reflected by IGF-I suppression of 30-43%. Thus, our work demonstrated the effective therapeutic potency of N-terminally mono-PEGylated GHA.

  3. Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients

    Directory of Open Access Journals (Sweden)

    Ozawa Takachika

    2009-08-01

    Full Text Available Abstract Background Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germline promoter hypermethylation of the tumor suppressor gene CDH1 (E-cadherin might cause predisposition to gastric cancer. Methods We prepared two groups of samples, a group of blood samples from 22 patients with familial gastric cancer or early-onset gastric cancer selected from among 39 patients, and a group of non-cancerous gastric tissue samples from 18 patients with sporadic gastric cancer showing loss of CDH1 expression selected from among 159 patients. We then investigated the allele-specific methylation status of the CDH1 promoter by bisulfite sequencing of multiple clones. Results Although there was a difference between the methylation level of the two alleles in some samples, there was no mono-allelic promoter hypermethylation in any of the samples. Conclusion These results suggest that germline mono-allelic hypermethylation of the CDH1 promoter is not a major predisposing factor for gastric cancer.

  4. Impacto del ejercicio de fuerza muscular en la prevención secundaria de la obesidad infantil: intervención al interior del sistema escolar

    Directory of Open Access Journals (Sweden)

    Fabián Vásquez

    2013-04-01

    Full Text Available Introducción: El ejercicio físico es una importante herramienta terapéutica para prevenir y tratar la obesidad y disminuir las alteraciones metabólicas asociadas al desarrollo de las enfermedades crónicas no transmisibles. Objetivo: Evaluar el impacto de una intervención al interior del sistema escolar, que incluye el ejercicio de fuerza muscular, educación alimentaria y apoyo psicológico en escolares obesos. Métodos: Se trabajó con 120 escolares obesos, entre 8 y 13 años, reclutados en 3 colegios. El Grupo 1 (n = 60, fueron intervenidos simultáneamente con ejercicio físico, educación alimentaria y apoyo psicológico durante 3 meses. El Grupo 2 (n = 60, durante el mismo período, recibió sólo la intervención educativa y el apoyo psicológico, siendo intervenido con ejercicio entre los 3 y los 6 meses. Se evaluó IMC, perímetro de cintura, grasa corporal, síndrome metabólico y factores de riesgo cardiovasculares. Resultados: A los 3 meses, hubo diferencias significativas entre ambos grupos en la variación del zIMC, circunferencia cintura, grasa corporal, síndrome metabólico, obesidad abdominal, hipertrigliceridemia e hiperglicemia de ayuno. En el grupo 1, estos parámetros disminuyeron y aumentaron, en el grupo 2. Entre los 3-6 meses, en el grupo 2, hubo una disminución significativa en la obesidad abdominal, presión arterial elevada e hipertrigliceridemia, en tanto en el grupo 1, aumento significativo de la presión arterial elevada sin variaciones en los otros factores de riesgo cardiovasculares. Conclusiones: Se demostró el impacto positivo del ejercicio físico de fuerza muscular en la reducción de la grasa corporal, del síndrome metabólico y de los factores de riesgo cardiovasculares. Este trabajo refuerza el uso del ejercicio como tratamiento de la obesidad y de sus comorbilidades en escolares.

  5. Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients

    OpenAIRE

    Boukli Nawal M; Shetty Vivekananda; Cubano Luis; Ricaurte Martha; Coelho-dos-Reis Jordana; Nickens Zacharie; Shah Punit; Talal Andrew H; Philip Ramila; Jain Pooja

    2012-01-01

    Abstract Background Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophysiology that mediates the rapid progression to hepatic disease in the co-infected individuals. Results In this study, we investigated the proteome profiles of peripheral blood mononuclear cells from HIV-1 mono-, HCV mono-, and HIV-1/HCV co-infected patients. The resul...

  6. Isoniazid Mono-Resistant Tuberculosis: Impact on Treatment Outcome and Survival of Pulmonary Tuberculosis Patients in Southern Mexico 1995-2010

    OpenAIRE

    Báez-Saldaña, Renata; Delgado-Sánchez, Guadalupe; García-García, Lourdes; Cruz-Hervert, Luis Pablo; Montesinos-Castillo, Marlene; Ferreyra-Reyes, Leticia; Bobadilla-del-Valle, Miriam; Canizales-Quintero, Sergio; Ferreira-Guerrero, Elizabeth; Téllez-Vázquez, Norma; Montero-Campos, Rogelio; Yanes-Lane, Mercedes; Mongua-Rodriguez, Norma; Martínez-Gamboa, Rosa Areli; Sifuentes-Osornio, José

    2016-01-01

    Background Isoniazid mono-resistance (IMR) is the most common form of mono-resistance; its world prevalence is estimated to range between 0.0 to 9.5% globally. There is no consensus on how these patients should be treated. Objective To describe the impact of IMR tuberculosis (TB) on treatment outcome and survival among pulmonary TB patients treated under programmatic conditions in Orizaba, Veracruz, Mexico. Materials and Methods We conducted a prospective cohort study of pulmonary TB patients...

  7. State of humoral link of immune system in children with mono- and mixed-variants of rotavirus infection

    Directory of Open Access Journals (Sweden)

    Катерина Олександрівна Сміян-Горбунова

    2015-09-01

    Full Text Available Connection of an immune system with infection agents defines the further development of infectious diseases especially rotavirus infection (RVI. The state of immune system before the beginning of disease and an adequacy of immune answer to causative agent defines the possibility of disease and its heaviness, duration of an acute period, cyclicity, time of pathogens elimination and period of reconvalescence. The humoral link is one of important components of immune system.Methods. 96 children 1 month-5 years old with acute intestinal infections of rotavirus etiology were under observation. 51 children with mono-variant of rotavirus infection formed the 1 group. The 11 group included 45 patients with mixed-variant of rotavirus infection. The control group included 32 practically healthy children. The research was carried out at the high point of disease (1–3 day and in period of reconvalescence. (5–6 day. The study of humoral link of immunity was carried out using the method of radial immunodiffusion in agar on Mancini G.Results. At comparison of indicators of the humoral link of immune system in children with mono- and mixed-variants of RVI at admission to hospital it was established that Ig М concentration in children of the 1 group was higher (р<0,05, and Ig G level in blood serum lower(р<0,05 than in the 11 group. So the study of the humoral immunity in blood serum in children with rotavirus infection revealed changes that were presented as an increase of Ig М and IgG indicators and also decrease of IgА. An assessment of an immune system after treatment within this research is characterized with an increase of IgА and IgG and decrease of IgМ.Conclusions. In blood serum of children with mono- and mixed-variants of rotavirus infection in an acute period of disease there was observed decrease of Ig А concentration and increase of Ig М і IgG. In the period of reconvalescence in children with mono- and mixed-variants of an acute

  8. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Tetz, Lauren M., E-mail: ltetz@umich.edu [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Cheng, Adrienne A.; Korte, Cassandra S. [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Giese, Roger W.; Wang, Poguang [Department of Pharmaceutical Sciences, Northeastern University, 360 Huntingon Ave, Boston, MA 02115 (United States); Harris, Craig; Meeker, John D.; Loch-Caruso, Rita [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States)

    2013-04-01

    Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is linked to the pathology of adverse pregnancy outcomes, effects of DEHP metabolites, including the active metabolite, mono-2-ethylhexyl phthalate (MEHP), on oxidative stress responses in placental cells have not been previously evaluated. The objective of the current study is to identify MEHP-stimulated oxidative stress responses in human placental cells. We treated a human placental cell line, HTR-8/SVneo, with MEHP and then measured reactive oxygen species (ROS) generation using the dichlorofluorescein assay, oxidized thymine with mass-spectrometry, redox-sensitive gene expression with qRT-PCR, and apoptosis using a luminescence assay for caspase 3/7 activity. Treatment of HTR-8 cells with 180 μM MEHP increased ROS generation, oxidative DNA damage, and caspase 3/7 activity, and resulted in differential expression of redox-sensitive genes. Notably, 90 and 180 μM MEHP significantly induced mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2), an enzyme important for synthesis of prostaglandins implicated in initiation of labor. The results from the present study are the first to demonstrate that MEHP stimulates oxidative stress responses in placental cells. Furthermore, the MEHP concentrations used were within an order of magnitude of the highest concentrations measured previously in human umbilical cord or maternal serum. The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes. - Highlights: ► MEHP increased reactive oxygen species, oxidative DNA damage, and caspase activity. ► MEHP induced expression of PTGS2, a gene

  9. Seasonal variation of mono- and sesquiterpene emission rates of Scots pine

    Directory of Open Access Journals (Sweden)

    H. Hakola

    2006-01-01

    Full Text Available The seasonal variation of mono-and sesquiterpene emission rates of Scots pine was measured from April to October in 2004. The emission rates were measured daily in the afternoons with the exception of weekends. Emissions were measured from two branches; one of them was debudded in May (branch A, while the other was allowed to grow new needles (branch B. The monoterpene emission pattern remained almost constant throughout the measurement period, Δ3-carene being the dominant monoterpene (50-70% of the VOC emission. The standard monoterpene emission potential (30°C was highest during early summer in June (the average of the two branches 1.35 µg g-1h-1 and lowest during early autumn in September (the average of the two branches 0.20 µg g-1h-1. The monoterpene emission potential of branch A remained low also during October, whereas the emission potential of branch B was very high in October. The sesquiterpenes were mainly emitted during mid summer, the dominant sesquiterpene being β-caryophyllene. Branch A had a higher sesquiterpene emission potential than branch B and the emission maximum occurred concomitant with the high concentration of airborne pathogen spores suggesting a potential defensive role of the sesquiterpene emissions. The sesquiterpene emissions were well correlated with linalool and 1,8-cineol emissions, but not with monoterpenes. Sesquiterpene and 1,8-cineol emissions were equally well described by the temperature dependent and the temperature and light dependent algorithms. This is due to the saturation of the light algorithm as the measurements were always conducted during high light conditions.

  10. Bio-methanization of energy crops through mono-digestion for continuous production of renewable biogas

    Energy Technology Data Exchange (ETDEWEB)

    Demirel, Burak [Lifetec Process Engineering, Hamburg University of Applied Sciences, Lohbruegger Kirchstrasse 65, 21033 Hamburg-Bergedorf (Germany); Bogazici University, Institute of Environmental Sciences, Bebek 34342, Istanbul (Turkey); Scherer, Paul [Lifetec Process Engineering, Hamburg University of Applied Sciences, Lohbruegger Kirchstrasse 65, 21033 Hamburg-Bergedorf (Germany)

    2009-12-15

    The aim of this laboratory-scale study was to investigate the long-term anaerobic fermentation of an extremely sour substrate, an energy crop, for continuous production of methane (CH{sub 4}) as a source of renewable energy. The sugar beet silage was used as the mono-substrate, which had a low pH of around 3.3-3.4, without the addition of manure. The mesophilic biogas digester was operated in a hydraulic retention time (HRT) range between 15 and 9.5 days, and an organic loading rate (OLR) range of between 6.33 and 10 g VS l{sup -1} d{sup -1}. The highest specific gas production rate (spec. GPR) and CH{sub 4} content were 0.67 l g VS{sup -1} d{sup -1} and 74%, respectively, obtained at an HRT of 9.5 days and OLR of 6.35 g VS l{sup -1} d{sup -1}. The digester worked within the neutral pH range as well. Since this substrate lacked the availability of macro and micro nutrients, and the buffering capacity as well, external supplementation was definitely required to provide a stable and efficient operation, as provided using NH{sub 4}Cl and KHCO{sub 3} in this case. The findings of this ongoing long-term fermentation of an extremely acidic biomass substrate without manure addition have reflected crucial information about how to appropriately maintain the operational and particularly the environmental parameters in an agricultural biogas plant. (author)

  11. Atomic-level simulations of nanoindentation-induced phase transformation in mono-crystalline silicon

    Science.gov (United States)

    Lin, Yen-Hung; Chen, Tei-Chen; Yang, Ping-Feng; Jian, Sheng-Rui; Lai, Yi-Shao

    2007-12-01

    Molecular dynamics (MD) simulations of nanoindentation are carried out to investigate the phase transformations in Si with a spherical indenter. Since the phase transformation induced by deformation in micro-scale is closely related to the carrier mobility of the material, it has become a key issue to be investigated for the chips especially with smaller feature size. Up to now, however, it is not possible to carry out the nanoindentation experimentally in such a small feature. Consequently, molecular dynamic simulation on nanoindentation is resorted to and becomes a powerful tool to understand the detailed mechanisms of stress-induced phase transformation in nano-scale. In this study, the inter-atomic interaction of Si atoms is modeled by Tersoff's potential, while the interaction between Si atoms and diamond indenter atoms is modeled by Morse potential. It is found that the diamond cubic structure of Si in the indentation zone transforms into a phase with body-centred tetragonal structure (β-Si) just underneath the indenter during loading stage and then changes to amorphous after unloading. By using the technique of coordinate number the results reveal that indentation on the (0 0 1) surface exhibits significant phase transformation along the direction. In addition, indentation on the (1 1 0) surface shows more significant internal slipping and spreading of phase transformation than on the (0 0 1) surface. Furthermore, during the indentation process phase transformations of Si are somewhat reversible. Parts of transformed phases that are distributed over the region of elastic deformation can be gradually recovered to original mono-crystal structure after unloading.

  12. Effects of mono-(2-ethylhexyl) phthalate (MEHP) on chicken germ cells cultured in vitro.

    Science.gov (United States)

    Guibert, Edith; Prieur, Bérénice; Cariou, Ronan; Courant, Frédérique; Antignac, Jean Philippe; Pain, Bertrand; Brillard, Jean Pierre; Froment, Pascal

    2013-05-01

    In recent decades, many toxicological tests based on in vivo or in vitro models, mainly from mammalian (rat-mouse) and fish species, were used to assess the risks raised by contact or ingestion of molecules of pharmaceutical, agricultural, or natural origin. But no, or few, in vitro tests using other non-mammalian models such as bird have been explored despite their advantages: the embryonic gonads of birds have a high plasticity of development sensitive to estrogen, and sperm production is nearly two times faster than in rodents. Hence, we have established an in vitro culture of germ cells and somatic cells from chicken post-natal testis, and we have evaluated the sensitivity against the endocrine disruptor compound mono-(2-ethylhexyl) phthalate (MEHP) in comparison to previous studies using rodent and human models. After 96 h of exposure in presence of 10 μM MEHP, chicken seminiferous tubules cultures present a structural alteration, a reduction in cell proliferation and in germ cells population. Apoptosis of germ and somatic cells increases in presence of 1 μM MEHP. Furthermore, MEHP does not affect inhibin B and lactate production by Sertoli cells. These results are in accordance with previous studies using rat, mice, or human culture of testicular cells and in similar range of exposures or even better sensitivity for some "end-points" (biological parameters). In conclusion, the establishment of this postnatal testicular cells culture could be considered as an alternative method to in vivo experiments frequently used for evaluating the impact on the terrestrial wildlife species. This method could be also complementary to mammal model due to the limiting number of animals used and its elevated sensitivity.

  13. Chromosome engineering: generation of mono- and dicentric isochromosomes in a somatic cell hybrid system.

    Science.gov (United States)

    Higgins, A W; Schueler, M G; Willard, H F

    1999-08-01

    The most common isochromosome found in humans involves the long arm of the X, i(Xq), and is associated with a subset of Turner syndrome cases. To study the formation and behavior of isochromosomes in a more tractable experimental system, we have developed a somatic cell hybrid model system that allows for the selection of mono- or dicentric isochromosomes involving the short arm of the X, i(Xp). Simultaneous positive and negative counterselection of a mouse/human somatic cell hybrid containing a human X chromosome, selecting for retention of the UBE1 locus in Xp but against the HPRT locus in Xq, results in a variety of abnormalities of the X chromosome involving deletions of Xq. We have generated 70 such "Pushmi-Pullyu" hybrids derived from seven independent X chromosomes. Cytogenetic analysis of these hybrids using fluorescence in situ hybridization showed i(Xp) chromosomes in approximately 19% of the hybrids. Southern blot and polymerase chain reaction analyses of the Pushmi-Pullyu hybrids revealed a distribution of breakpoints along Xq. The distance between the centromeres of the dicentric i(Xp)s generated ranged from approximately 2 Mb to approximately 20 Mb. To examine centromeric activity in these dicentric i(Xp)s, we used indirect immunofluorescence with antibodies to centromere protein E (CENP-E). CENP-E was detected at only one of the centromeres of a dicentric i(Xp) with approximately 2-3 Mb of Xq DNA. In contrast, CENP-E was detected at both centromeres of a dicentric i(Xp) with approximately 14 Mb of Xq DNA. Two other dicentric i(Xp) chromosomes were heterogeneous with respect to centromeric activity, suggesting that centromeric activity and chromosome stability of dicentric chromosomes may be more complicated than previously thought. The Pushmi-Pullyu model system presented in this study may provide a tool for examining the structure and function of mammalian centromeres.

  14. Electro-spray of high viscous liquids for producing mono-sized spherical alginate beads

    Institute of Scientific and Technical Information of China (English)

    Hamid Moghadam; Mohsen Samimi; Abdolreza Samimi; Mohamad Khorram

    2008-01-01

    Alginate beads, often used for controlled release of enzymes and drugs, are usually produced by spraying sodium alginate liquid into a gelling agent using mechanical vibration nozzle or air jet. In this work an alternative method of electro-spray was employed to form droplets with desired size from a highly viscous sodium alginate solution using constant DC voltage. The droplets were then cured in a calcium chloride solution. The main objective was to produce mono-sized beads from such a highly viscous and non-Newtonian liquid (1000-5000 mPa s). The effects of nozzle diameter, flow rate and concentration of liquid on the size of the beads were investigated. Among the parameters studied, voltage had a pronounced effect on the size of beads as compared to flow rate zzle diameter and concentration of alginate liquid. The size of beads was reduced to a minimum value with increasing the voltage in the range of 0-10 kV. At the early stages of voltage increase (I.e. Up to about 4 kV), the rate of size reduction was relatively low, while the dripping mode dominated. However, in the middle part of the range of applied voltage, where the rate of size reduction was high (I.e. About 4-7 kV), an unstable transition occurred between dripping and jetting. At the end part of the range (I.e. 7-10 kV) jet mode of spray was observed. Increasing the height of fall of the droplets was found to improve the sphericity of the beads, because of the increased time of flight for the droplets. This was especially identifiable at higher concentrations of the alginate liquid (I.e. 3 w/v%)

  15. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl phthalate (MEHP.

    Directory of Open Access Journals (Sweden)

    Wenhui Zhai

    Full Text Available Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting in widespread distribution in aquatic environments. However, limited information is available on the endocrine disrupting effects of phthalates in aquatic organisms. The aim of the present study was to examine whether exposure to mono-(2-ethylhexyl phthalate (MEHP, the hydrolytic metabolite of di-(2-ethylhexyl phthalate (DEHP disrupts thyroid endocrine system in fish. In this study, zebrafish (Danio rerio embryos were exposed to different concentrations of MEHP (1.6, 8, 40, and 200 μg/L from 2 h post-fertilization (hpf to 168 hpf. The whole-body content of thyroid hormone and transcription of genes involved in the hypothalamic-pituitary-thyroid (HPT axis were examined. Treatment with MEHP significantly decreased whole-body T4 contents and increased whole-body T3 contents, indicating thyroid endocrine disruption. The upregulation of genes related to thyroid hormone metabolism (Dio2 and UGT1ab might be responsible for decreased T4 contents. Elevated gene transcription of Dio1 was also observed in this study, which might assist to degrade increased T3 contents. Exposure to MEHP also significantly induced transcription of genes involved in thyroid development (Nkx2.1 and Pax8 and thyroid hormone synthesis (TSHβ, NIS and TG. However, the genes encoding proteins involved in TH transport (transthyretin, TTR was transcriptionally significantly down-regulated after exposure to MEHP. Overall, these results demonstrate that acute exposure to MEHP alters whole-body contents of thyroid hormones in zebrafish embryos/larvae and changes the transcription of genes involved in the HPT axis, thus exerting thyroid endocrine toxicity.

  16. Scenario earthquake hazards for the Long Valley Caldera-Mono Lake area, east-central California

    Science.gov (United States)

    Chen, Rui; Branum, David M.; Wills, Chris J.; Hill, David P.

    2014-01-01

    As part of the U.S. Geological Survey’s (USGS) multi-hazards project in the Long Valley Caldera-Mono Lake area, the California Geological Survey (CGS) developed several earthquake scenarios and evaluated potential seismic hazards, including ground shaking, surface fault rupture, liquefaction, and landslide hazards associated with these earthquake scenarios. The results of these analyses can be useful in estimating the extent of potential damage and economic losses because of potential earthquakes and in preparing emergency response plans. The Long Valley Caldera-Mono Lake area has numerous active faults. Five of these faults or fault zones are considered capable of producing magnitude ≥6.7 earthquakes according to the Uniform California Earthquake Rupture Forecast, Version 2 (UCERF 2) developed by the 2007 Working Group of California Earthquake Probabilities (WGCEP) and the USGS National Seismic Hazard Mapping (NSHM) Program. These five faults are the Fish Slough, Hartley Springs, Hilton Creek, Mono Lake, and Round Valley Faults. CGS developed earthquake scenarios for these five faults in the study area and for the White Mountains Fault to the east of the study area. Earthquake scenarios are intended to depict the potential consequences of significant earthquakes. They are not necessarily the largest or most damaging earthquakes possible. Earthquake scenarios are both large enough and likely enough that emergency planners should consider them in regional emergency response plans. Earthquake scenarios presented here are based on fault geometry and activity data developed by the WGCEP, and are consistent with the 2008 Update of the United States National Seismic Hazard Maps (NSHM).For the Hilton Creek Fault, two alternative scenarios were developed in addition to the NSHM scenario to account for different opinions in how far north the fault extends into the Long Valley Caldera. For each scenario, ground motions were calculated using the current standard practice

  17. Volver al desarrollo

    Directory of Open Access Journals (Sweden)

    Jaime Ornelas Delgado

    2012-01-01

    Full Text Available El desarrollo, categoría empleada para expresar el crecimiento económico, surge durante la "guerra fría" y si bien fue propuesta por teóricos metropolitanos, se asumió en Latinoamérica como parte de los instrumentos disponibles para lograr el crecimiento y alternativa al socialismo. El desarrollo mantuvo su vigencia entre 1945 y 1975, cuando al advenimiento del neoliberalismo fue paulatinamente retirado de la agenda de las preocupaciones nacionales e internacionales. Al iniciarse el siglo xxi, el fracaso del mercado autorregulado trajo de nueva cuenta al debate los problemas del desarrollo, lo que obliga a revisarlo críticamente, tanto como al concepto mismo para mostrar su carácter colonial, si se quiere construir caminos ajenos al neoliberal y superar los problemas que han hecho de Latinoamérica una de las regiones más desiguales del mundo.

  18. Progress of Inosine Mono-phosphate(IMP) and Guanosine Mono-phosphate(GMP) Acid Production by Microbial Technology%利用微生物技术生产肌苷酸和鸟苷酸的进展

    Institute of Scientific and Technical Information of China (English)

    王美玲

    2014-01-01

    肌苷酸( IMP)和鸟苷酸( GMP)是非常有效的风味增强剂。它们和谷氨酸钠(味精)一起被广泛用作食品添加剂,共同发挥增强食物鲜味的作用。近年来,由于具有抗氧化性、神经保护作用、强心剂作用和免疫调节等有利作用,嘌呤类核苷酸都展现出了重要性。本综述回顾了利用微生物技术生产IMP和GMP的进展,包括其合成的代谢途径和调控网络,以及为获得这些嘌呤化合物所采用的生物技术流程和所用微生物菌种。%Inosine mono -phosphate ( IMP ) and guanosine mono -phosphate ( GMP ) are very effective flavor enhancers.They and mono-sodium glutamate (MSG) are widely used as food additives, working together to enhance the role of food flavors .In recent years ,with antioxidant activity ,neuro protective car-diac function and other favorable immunomodulatory effects of purine nucleotides ,they are showing further importance .The progress of microbial technology used to produce IMP and GMP are reviewed in this pa-per,including the synthesis of metabolic pathways and regulatory networks , as well as the biotechnology processes used to accept these purine compounds and microbial strains used .

  19. Alles is al uitgevonden

    NARCIS (Netherlands)

    J.G.M. van Marrewijk (Charles)

    1996-01-01

    textabstractDe voordelen van vrijhandel zijn zeer beperkt, al-thans als we de empirische schattingen van vooraanstaande economen en internationale organisaties mogen geloven. Zo worden de voordelen van liberalisatie voor de Europese Unie geraamd op ongeveer 0,5% van het bnp 1. De door het IMF gescha

  20. Gezondheid als marketinginstrument

    NARCIS (Netherlands)

    Vijver, van de L.P.L.; Berg, van den I.

    2008-01-01

    Is biologisch voedsel beter dan gangbaar? Hoe hard zijn de bewijzen daarvoor? En hoe sterk moet het bewijs zijn voordat je het als claim op een product mag zetten? In dit Biokennis bericht een overzicht van de wetenschappelijke conclusies en de mogelijkheden om biologisch te promoten als beter, neer

  1. Initial Symptoms of ALS

    Science.gov (United States)

    ... Research In Your Community Advocate Get Involved Donate Symptoms and Diagnosis En español Symptoms The initial symptoms of ALS can be quite ... the eyes and bladder are generally not affected. Diagnosis ALS is a difficult disease to diagnose. There ...

  2. Obtention of Samarium and Gadolinium concentrates by solvent extraction using mono-2-ethylhexyl ester of 2-ethylhexyl phosphonic acid; Obtencao de concentrados de samario e gadolinio via extracao por solventes com o ester mono-2-etilhexil do acido 2-etilhexilfosfonico

    Energy Technology Data Exchange (ETDEWEB)

    Miranda Junior, Pedro

    1996-07-01

    The rare earth chlorides solution employed in this study, which is constituted by medium and heavy fractions, is derived from monazite processing accomplished by NUCLEMON-Mineroquimica (SP). This solution shows an acidity about 1.18 M and 189 g/L of rare earth oxides, containing as main constituents: Sm(34.55%), Gd(23.85%), Dy (6.82%), and Y (24.45%). It was used, as organic phase, 2-ethylhexyl phosphonic acid, mono-2-ethylhexylester diluted to 1 M in isododecane. (author)

  3. Versatile sputtering technology for Al2O3 gate insulators on graphene

    Directory of Open Access Journals (Sweden)

    Miriam Friedemann, Mirosław Woszczyna, André Müller, Stefan Wundrack, Thorsten Dziomba, Thomas Weimann and Franz J Ahlers

    2012-01-01

    Full Text Available We report a novel, sputtering-based fabrication method of Al2O3 gate insulators on graphene. Electrical performance of dual-gated mono- and bilayer exfoliated graphene devices is presented. Sputtered Al2O3 layers possess comparable quality to oxides obtained by atomic layer deposition with respect to a high relative dielectric constant of about 8, as well as low-hysteresis performance and high breakdown voltage. We observe a moderate carrier mobility of about 1000 cm2 V− 1 s−1 in monolayer graphene and 350 cm2 V− 1 s−1 in bilayer graphene, respectively. The mobility decrease can be attributed to the resonant scattering on atomic-scale defects, likely originating from the Al precursor layer evaporated prior to sputtering.

  4. Comparisons of ZnO codoped by group ⅢA elements(Al,Ga,In)and N: a first-principle study*

    Institute of Scientific and Technical Information of China (English)

    Li Ping; Deng Sheng-Hua; Zhang Li; Yu Jiang-Ying; Liu Guo-Hong

    2010-01-01

    The electronic structures and effective masses of the N mono-doped and Al-N,Ga-N,In-N codoped ZnO system have been calculated by a first-principle method,and comparisons among different doping cases are made.According to the results,the impurity states in the codoping cases are more delocalised compared to the N mono-doping case,which means a better conductive behaviour can be obtained by codoping.Besides,compared to the Al-N and Ga-N codoping cases,the hole effective mass of In-N codoped system is much smaller,indicating the p-type conductivity can be more enhanced by In-N codoping.

  5. Laboratory investigations on continuous bio-methanization of energy crops as mono-substrate without supplementation

    Energy Technology Data Exchange (ETDEWEB)

    Demirel, Burak [Hamburg University of Applied Sciences (HAW Hamburg), Lifetec Process Engineering, Lohbruegger Kirchstrasse 65, 21033 Hamburg-Bergedorf (Germany); Bogazici University, Institute of Environmental Sciences, Bebek, 34342 Istanbul (Turkey)

    2009-06-15

    Continuous bio-methanization of an energy crop, namely the beet silage, was investigated in this laboratory-scale work as mono-substrate, using a mesophilic biogas digester controlled by a fuzzy logic control (FLC) technique and without using any supplementing or buffering agent, despite the low pH of the substrate around 3.80. The temperature, pH, redox potential (ORP), daily biogas production and composition of digester biogas were continuously measured online. During the operation, the hydraulic retention time (HRT) varied between 24.8 and 9 days, as the organic loading rate (OLR) ranged from 2.6 to 4.7 g L{sup -1} d{sup -1}. The average pH, specific gas production rate (spec. GPR) and volumetric gas production rate (vol. GPR) were determined to be 7.12, 0.31 L g VS{sup -1} d{sup -1} and 1.084 L L{sup -1} d{sup -1}, respectively. The average methane (CH{sub 4}) content of digester biogas was about 56%. The FLC technique, which was developed at HAW Hamburg for anaerobic conversion of acidic energy crops to methane, determined the daily feeding volume ({proportional_to} OLR/HRT) for the biogas digester, depending on the feedback from online pH and methane measurements, and on the calculation of the spec. GPR. The spec. GPR was calculated by the corrected daily biogas production. Through online monitoring of pH, biogas production rate and composition, and by use of the FLC technique, the acidic beet silage could continuously be converted to biogas, without using manure or any other kind of buffering or supplementing agent(s). The lab-scale anaerobic biogas digester performed stable and safe, without encountering any problems of instability, as indicated by an adequate amount of buffering capacity, a VFA content below 0.5 g L{sup -1} and a neutral pH range throughout the study. (author)

  6. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Directory of Open Access Journals (Sweden)

    Musso CG

    2006-03-01

    Full Text Available RESUMEN:La insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia.En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal. SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one.In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  7. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Directory of Open Access Journals (Sweden)

    Musso CG

    2007-04-01

    Full Text Available RESUMENLa insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia. En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal.SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one. In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  8. Niveles séricos de leptina y su relación con la excreción de sodio en niños y adolescentes obesos Relationship between serum leptin levels and sodium excretion in a local population of obese children and adolescents

    Directory of Open Access Journals (Sweden)

    A. Maskin de Jensen

    2011-09-01

    Full Text Available La obesidad se asocia con niveles elevados de leptina y la mayoría de los individuos obesos presentan resistencia "selectiva" a su acción metabólica sin disminución del apetito ni aumento en el gasto energético, con preservación y estimulación de la activación del sistema simpático a nivel central y de las acciones periféricas cardiovasculares y renales. Estos mecanismos podrían modificar la regulación del metabolismo del sodio a nivel renal. Objetivo: identificar el comportamiento de los niveles séricos de leptina en asociación a la excreción urinaria de sodio en una población de niños y adolescentes obesos. Material y métodos: se estudiaron 190 niños y adolescentes entre 5 y 15 años: 125 con índice de masa corporal (IMC percentilo = 95 constituyeron el grupo de obesos (OB y 65 con IMC percentilo 5 - Obesity is associated with elevated levels of leptin and most obese individuals are "selectively" resistant to its metabolic action, without appetite loss or increased energy expenditure, with preservation and stimulation of the activation of the sympathetic system at both the central and peripheral cardiovascular and renal levels. These mechanisms could modify the regulation of sodium metabolism in the kidney. Objective: To determine whether there is any correlation among between serum leptin levels and urinary sodium excretion in a population of obese children and adolescents an obese, children and adolescents. Material and methods: 190 children and adolescents between 5 and 15 years of age were studied: 125 with body mass index (BMI = 95 percentile constituted the obese group (OB and 65 with BMI percentile 5 - < 85 the control group (C. Concentrations of serum sodium (Na and urinary sodium (Nao were measured with ion selective electrode; serum leptin levels were measured by the immunoradiometric method. Results: Differences between groups were significantly lower for urinary sodium values (mEq/kg/day in obese subjects

  9. Efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I Effects of greater-than-5% weight reduction on hemodynamic, metabolic and neuroendocrine profiles of grade I obese subjects

    Directory of Open Access Journals (Sweden)

    Kelly Biancardini Gomes Barbato

    2006-07-01

    Full Text Available OBJETIVO: Avaliar os efeitos da redução de peso superior a 5% nos perfis hemodinâmico, metabólico e neuroendócrino de obesos grau I. MÉTODOS: Estudo observacional com 47 obesos grau I, média de idade de 33 anos, submetidos a orientação mensal quanto a dieta, exercício físico e comportamento alimentar, durante quatro meses. A pressão arterial, pelo método auscultatório, e a freqüência cardíaca, pelo método palpatório, foram avaliadas mensalmente, enquanto as seguintes variáveis (e respectivos métodos foram medidas no início e final do estudo: colesterol total, triglicerídeos, HDL-colesterol (enzimático, LDL-colesterol (fórmula de Friedwald, glicemia (enzimático hexoquinase, leptina, adiponectina, renina, aldosterona, insulina (radioimunoensaio e índice de resistência à insulina (HOMA. RESULTADOS: Observamos, após ajuste para outras variáveis, reduções significativas de 6 mmHg na pressão arterial diastólica, 7 pg/ml na renina, 13 mg/dl no colesterol total e 12 mg/dl no LDL-colesterol, no grupo com redução de peso superior a 5%. Notamos, também nesse grupo, tendência ao aumento de maior magnitude da adiponectina ao final do estudo, bem como diminuição três vezes maior dos níveis de glicemia, insulina e HOMA, e seis vezes maior da leptina. CONCLUSÃO: Medidas não-farmacológicas capazes de promover redução de peso superior a 5% produzem efeitos hemodinâmicos, metabólicos e neuroendócrinos que melhoram o risco cardiovascular de obesos.OBJECTIVE: To evaluate the effects of a greater-than-5% weight reduction in hemodynamic, metabolic, and neuroendocrine profiles of grade I obese subjects. METHODS: Observational study with 47 grade I obese subjects, with mean age of 33 years who received monthly orientation regarding diet, physical exercises, and eating behavior for four months. Blood pressure using the auscultatory method and pulse rate were assessed monthly, whereas the following variables (and

  10. Research on the effects of machining-induced subsurface damages on mono-crystalline silicon via molecular dynamics simulation

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Hongwei, E-mail: hwzhao@jlu.edu.cn [College of Mechanical Science and Engineering, Jilin University, 5988 Renmin Street, Changchun, Jilin 130025 (China); Shi Chengli; Zhang Peng; Zhang Lin; Huang Hu; Yan Jiwang [College of Mechanical Science and Engineering, Jilin University, 5988 Renmin Street, Changchun, Jilin 130025 (China)

    2012-10-15

    Highlights: Black-Right-Pointing-Pointer MD simulations of nano-cutting process are carried out to obtain machining-induced subsurface with diamond cutting tools. Black-Right-Pointing-Pointer After cutting, the crystal lattice reconstructed and led to the formation of the machined surface. Black-Right-Pointing-Pointer The mechanical properties of the pristine and machining-induced subsurface Si are studied by means of nanoindentation. Black-Right-Pointing-Pointer Nanoindentation results show that the hardness of the machined surface was smaller than mono-crystalline Si. - Abstract: Nanoindentation simulation via molecular dynamic (MD) method was carried out to investigate the characteristics of machining-induced subsurface damage of mono-crystalline silicon with a spherical diamond indenter. In this study, MD simulations of nano-cutting process were carried out firstly to cut through the specimen's surface with diamond cutting tools of different edge radius of 0 nm, 3 nm and 5 nm respectively. Then, MD simulation of nanoindentation on the machined surface was carried out. Tersoff potential was used to model the interaction of Si atoms, and the interaction between Si and C atoms was modeled by Morse potential. Simulational results indicate that during cutting process, the specimen undergo plastic deformation and phase transformation. After cutting process, the crystal lattice reconstructs and the residual amorphous layers lead to the formation of the machined surface. Nanoindentation results show that the hardness of the machined surface is smaller than mono-crystalline Si. So in order to get accurate properties of the pristine silicon or other semiconductor materials via experiments, the amorphous phase should be completely removed or it would influence the mechanical properties of the pristine materials.

  11. Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Zhen; Xu, Michael S.; Barnett, Tamara L. [Nevada Cancer Institute, Las Vegas, NV 89135 (United States); Xu, C. Wilson, E-mail: wxu@nvcancer.org [Nevada Cancer Institute, Las Vegas, NV 89135 (United States)

    2011-04-08

    Research highlights: {yields} Resveratrol induces cellular senescence in glioma cell. {yields} Resveratrol inhibits mono-ubiquitination of histone H2B at K120. {yields} Depletion of RNF20, phenocopies the inhibitory effects of resveratrol. {yields} Mono-ubiquitination of histone H2B at K120 is a novel target of resveratrol. {yields} RNF20 inhibits cellular senescence in proliferating glioma cells. -- Abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene), a polyphenol naturally occurring in grapes and other plants, has cancer chemo-preventive effects and therapeutic potential. Although resveratrol modulates multiple pathways in tumor cells, how resveratrol or its affected pathways converge on chromatin to mediate its effects is not known. Using glioma cells as a model, we showed here that resveratrol inhibited cell proliferation and induced cellular hypertrophy by transforming spindle-shaped cells to enlarged, irregular and flatten-shaped ones. We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-{beta}-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells. Consistent with these observations, we demonstrated that resveratrol inhibited clonogenic efficiencies in vitro and tumor growth in a xenograft model. Furthermore, we found that acute treatment of resveratrol inhibited mono-ubiquitination of histone H2B at K120 (uH2B) in breast, prostate, pancreatic, lung, brain tumor cells as well as primary human cells. Chronic treatment with low doses of resveratrol also inhibited uH2B in the resveratrol-induced senescent glioma cells. Moreover, we showed that depletion of RNF20, a ubiquitin ligase of histone H2B, inhibited uH2B and induced cellular senescence in glioma cells in vitro, thereby recapitulated the effects of resveratrol. Taken together, our results suggest that uH2B is a novel direct or indirect chromatin target of resveratrol and RNF20 plays an important role in inhibiting cellular

  12. Synthesis, fluorescence properties of Tb(Ⅲ) complexes with novel mono-substituted β-diketone ligands

    Institute of Scientific and Technical Information of China (English)

    罗一鸣; 李石凤; 李军; 陈学娟; 唐瑞仁

    2010-01-01

    Two novel pyridine-2,6-dicarboxylic acid derivatives of mono-β-diketone named methyl 6-biphenylacetyl-2-pyridinecarboxylate (MBP) and 6-biphenylacetyl-2-pyridinecarboxylic acid (BAA) and their corresponding binary complexes Tb(MBP)3.6H2O and Tb(BAA)3·6H2O were synthesized. The ligands were characterized by elemental analysis, FT-IR and 1H-NMR, and the complexes were characterized with elemental analysis, FT-IR, 1H-NMR and thermogravimetric and differential thermal analysis(TG-DTA). The investigation of fluo...

  13. Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis

    Energy Technology Data Exchange (ETDEWEB)

    Hirata, Fusao, E-mail: fhirata@wayne.edu; Harada, Takasuke; Corcoran, George B.; Hirata, Aiko

    2014-01-15

    Highlight: • Nuclear mono-ubiquitinated annexin A1 is involved in DNA damage induced mutagenesis. • Dietary flavonoids bind to and inhibit purified mono-ubiquitinated annexin A1 helicase. • Dietary flavonoids show anti-mutagenic action. • Annexin A1 may serve as a putative target of cancer chemoprevention by flavonoids. - Abstract: In order to investigate the mechanisms of anti-mutagenic action by dietary flavonoids, we investigated if they inhibit mutation of the thymidine kinase (tk) gene in L5178Ytk(±) lymphoma cells. Silibinin, quercetin and genistein suppressed mutation of the tk gene induced in L5178Ytk(±) lymphoma cells by methyl methanesulfonate (MMS) and As{sup 3+}. Flavone and flavonol were less effective. To establish that mutation of the tk gene in L5178Ytk(±) lymphoma cells by MMS and As{sup 3+} is mediated through mono-ubiquitinated annexin A1, L5178Ytk(±) lymphoma cells were treated with annexin A1 anti-sense oligonucleotide. The treatment reduced mRNA as well as protein levels of annexin A1, and suppressed mutation of the tk gene. Nuclear extracts from L5178Ytk(±) lymphoma cells catalyzed translesion DNA synthesis with an oligonucleotide template containing 8-oxo-guanosine in an annexin A1 dependent manner. This translesion DNA synthesis was inhibited by the anti-mutagenic flavonoids, silibinin, quercetin and genistein, in a concentration dependent manner, but only slightly by flavone and flavonol. Because these observations implicate involvement of annexin A1 in mutagenesis, we examined if flavonoids suppress nuclear annexin A1 helicase activity. Silibinin, quercetin and genistein inhibited ssDNA binding, DNA chain annealing and DNA unwinding activities of purified nuclear mono-ubiquitinated annexin A1. Flavone and flavonol were ineffective. The apparent direct binding of anti-mutagenic flavonoids to the annexin A1 molecule was supported by fluorescence quenching. Taken together, these findings illustrate that nuclear annexin A1 may be

  14. Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives (Ⅲ) : Mono-and bis-Schiff-bases

    Institute of Scientific and Technical Information of China (English)

    Guo Qiang Hu; Wen Long Huang; Xiao Kui Wu; Guo Qiang Wang; Nan Nan Duan; Xiao Yi Wen; Tie Yao Cao; Yin Jun; Wang Wei; Song Qiang Xie

    2012-01-01

    To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,monoSchiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.

  15. Efecto del enriquecimiento ambiental en un grupo de monos araña (Ateles geoffroyi) en cautiverio

    OpenAIRE

    Alejandra Márquez-Arias; Ana María Santillán-Doherty; Rita Virginia Arenas-Rosas; Marco Polo Gasca-Matías; Jairo Muñoz-Delgado; Javier Villanueva-Valle

    2014-01-01

    Los animales que viven en cautiverio padecen problemas relacionados con el estrés y la falta de estimulación. El enriquecimiento ambiental (EA) proporciona a los animales en esta situación un conjunto de actividades que los alienta a presentar conductas típicas de su especie. El objetivo de este trabajo fue analizar el efecto de un programa de EA en la conducta de una colonia de siete monos araña (Ateles geoffroyi). Se esperaba que la agresión, la coprofilia y las estereotipias fueran menos f...

  16. On the possibility of using short chain length mono-carboxylic acids for stabilization of magnetic fluids

    Energy Technology Data Exchange (ETDEWEB)

    Avdeev, Mikhail V. [Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna Moscow Region (Russian Federation)]. E-mail: avd@nf.jinr.ru; Bica, Doina [Laboratory of Magnetic Fluids, CFATR, Romanian Academy, Timisoara Division, Timisoara (Romania); Vekas, Ladislau [National Center for Engineering of Systems with Complex Fluids, University Politehnica, Timisoara (NC ESCF-UPT) (Romania); Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest-Magurele (Romania); Marinica, Oana [National Center for Engineering of Systems with Complex Fluids, University Politehnica, Timisoara (NC ESCF-UPT) (Romania); Balasoiu, Maria [Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna Moscow Region (Russian Federation); Research Institute for Solid State Physics and Optics, Hungarian Academy of Sciences, Budapest (Hungary); Aksenov, Victor L. [Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna Moscow Region (Russian Federation); Rosta, Laszlo [Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest-Magurele (Romania); Garamus, Vasil M. [GKSS Research Centre, Geesthacht (Germany); Schreyer, Andreas [GKSS Research Centre, Geesthacht (Germany)

    2007-04-15

    Short chain length mono-carboxylic acids (lauric and myristic acids) are used to coat magnetite nanoparticles in non-polar organic liquids, which results in highly stable magnetic fluids. The new fluids are compared with classical organic fluids stabilized by oleic acid (OA). Magnetic granulometry and small-angle neutron scattering (polarized mode) reveal a great difference in the particle size distribution function for the studied magnetic fluids, particularly a decrease in the characteristic particle radius of magnetite when lauric and myristic acids are used instead of OA.

  17. On the possibility of using short chain length mono-carboxylic acids for stabilization of magnetic fluids

    Science.gov (United States)

    Avdeev, Mikhail V.; Bica, Doina; Vékás, Ladislau; Marinica, Oana; Balasoiu, Maria; Aksenov, Victor L.; Rosta, László; Garamus, Vasil M.; Schreyer, Andreas

    2007-04-01

    Short chain length mono-carboxylic acids (lauric and myristic acids) are used to coat magnetite nanoparticles in non-polar organic liquids, which results in highly stable magnetic fluids. The new fluids are compared with classical organic fluids stabilized by oleic acid (OA). Magnetic granulometry and small-angle neutron scattering (polarized mode) reveal a great difference in the particle size distribution function for the studied magnetic fluids, particularly a decrease in the characteristic particle radius of magnetite when lauric and myristic acids are used instead of OA.

  18. Stochastic Resonance in an Asymmetric Mono-stable System Subject to Two Periodic Forces and Multiplicative and Additive Noise

    Institute of Scientific and Technical Information of China (English)

    LUO Xiang-Dong; GUO Feng; ZHOU Yu-Rong

    2009-01-01

    The phenomenon of stochastic resonance (SR) in an asymmetric mono-stable system subject to two external periodic forces and multiplicative and additive noise is investigated.It is shown that the signal-to-noise ratio (SNR) for the fundamental and higher harmonics is a non-monotonic function of the intensities of the multiplicative and additive noise, as well as of the system parameter.Moreover, the SNR for the fundamental harmonic decreases with the increase of the system asymmetry, while the SNR for the higher harmonics behaves non-monotonically as the system asymmetry varies.

  19. [Comparative study of postprandial glycaemia in type 2 diabetic patients after consumption of mono- and disaccharides and sweeteners].

    Science.gov (United States)

    Sharafetdinov, Kh Kh; Meshcheriakova, V A; Plotnikova, O A; Gapparov, M G

    2002-01-01

    It was investigated the influence of mono- and disaccharides, sugar alcohols, honey, corn patoka and products with nutritive and nonnutritive sweeteners on dynamic of postprandial glycaemia in type 2 diabetic patients. After ingestion of 30 g fructose, blood glucose did not show a marked increase in comparison with sucrose or honey. After ingestion of 30 g sorbitol or isomalt, blood glucose curve was not significantly different. It was indicated that corn patoka in chewing candies with isomalt has a high hyperglycaemic effect whereas drink with nonnutritive sweeteners did not change blood glucose from fasting levels.

  20. STABILITY OF EMULSIFIER-FREE EMULSION COPOLYMERIZATION OF METHYL METHACRYLATE/ BUTYL ACRYLATE/SODIUM MONO(ETHYL POLYOXYETHYLENE) MALEATE

    Institute of Scientific and Technical Information of China (English)

    Mao-gen Zhang; Zhi-xue Weng; Zhi-ming Huang; Zu-ren Pan

    1999-01-01

    A series of new water-soluble bifunctional comonomers having both carboxyl and alkyl polyoxyethylene groups, such as sodium mono(ethyl polyoxyethylene) maleate (ZE series) with various molecular weights of polyoxyethylene ethyl ether, were synthesized and characterized. The effects of the structural factor, the amount and feeding mode of the comonomers, the initiator concentration and polymerization temperature on the stability of emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and butyl acrylate (BA) in the presence of a small amount of ZE with potassium persulfate as initiator were investigated. Stable, almost monodispersed MMA/BA/ZE emulsifier-free latex particles were prepared.