Exenatide. Amylin/Eli Lilly.

Science.gov (United States)

Giannoukakis, Nick

2003-04-01

Amylin Pharmaceuticals Inc and Eli Lilly & Co are co-developing exenatide (AC-2993; synthetic exendin-4), a 39-amino acid, glucagon-like peptide-1 agonist derived from the venom of the Gila monster lizard (Heloderma suspectum) as a potential injectable treatment for type 2 diabetes. The first phase III trial (exenatide as a monotherapy) was initiated in December 2001. In January 2002 the second phase III trial, of exenatide in conjunction with sulfonylureas, was initiated and in March 2002, Amylin initiated the third phase III trial, of exenatide in combination with metformin and sulfonylureas.

Love, lust and the emotional context of multiple and concurrent ...

African Journals Online (AJOL)

Love, lust and the emotional context of multiple and concurrent sexual partnerships among young Swazi adults. Allison Ruark, Lunga Dlamini, Nonhlanhla Mazibuko, Edward C Green, Caitlin Kennedy, Amy Nunn, Timothy Flanigan, Pamela J Surkan ...

Oritavancin. Eli Lilly & Co.

Science.gov (United States)

Barrett, J F

2001-08-01

Oritavancin (LY-333328), a lead glycopeptide from a series targeted at vancomycin-resistant bacteria, especially enterococci, is under development by Eli Lilly for the potential treatment of bacterial infections. It entered phase III trials in the US in January 2001 [396223] and the company expects to submit an NDA by 2003 [396478]. Oritavancin has been reported to have activity comparable to that of vancomycin and teicoplanin (Aventis Pharma AG), but retains activity against glycopeptide-resistant bacterial strains [407519]. The bactericidal activity of oritavancin suggests that it may prove useful as a single agent therapy in the treatment of antibiotic-resistant enterococci. Although its mechanism of action is unclear, dimerization of the glycosyl portion stabilizing D-Ala-D-Ala binding has been suggested [337644].

L.U.St: a tool for approximated maximum likelihood supertree reconstruction.

Science.gov (United States)

Akanni, Wasiu A; Creevey, Christopher J; Wilkinson, Mark; Pisani, Davide

2014-06-12

Supertrees combine disparate, partially overlapping trees to generate a synthesis that provides a high level perspective that cannot be attained from the inspection of individual phylogenies. Supertrees can be seen as meta-analytical tools that can be used to make inferences based on results of previous scientific studies. Their meta-analytical application has increased in popularity since it was realised that the power of statistical tests for the study of evolutionary trends critically depends on the use of taxon-dense phylogenies. Further to that, supertrees have found applications in phylogenomics where they are used to combine gene trees and recover species phylogenies based on genome-scale data sets. Here, we present the L.U.St package, a python tool for approximate maximum likelihood supertree inference and illustrate its application using a genomic data set for the placental mammals. L.U.St allows the calculation of the approximate likelihood of a supertree, given a set of input trees, performs heuristic searches to look for the supertree of highest likelihood, and performs statistical tests of two or more supertrees. To this end, L.U.St implements a winning sites test allowing ranking of a collection of a-priori selected hypotheses, given as a collection of input supertree topologies. It also outputs a file of input-tree-wise likelihood scores that can be used as input to CONSEL for calculation of standard tests of two trees (e.g. Kishino-Hasegawa, Shimidoara-Hasegawa and Approximately Unbiased tests). This is the first fully parametric implementation of a supertree method, it has clearly understood properties, and provides several advantages over currently available supertree approaches. It is easy to implement and works on any platform that has python installed. bitBucket page - https://afro-juju@bitbucket.org/afro-juju/l.u.st.git. Davide.Pisani@bristol.ac.uk.

The good gift: a comparison of the Eli Lilly presentation copies of Aequanimitas.

Science.gov (United States)

Kimbrough, R C

1995-08-01

The Eli Lilly Pharmaceutical Company of Indianapolis, Indiana distributed some 150,000 copies of the third edition of Sir William Osler's Aequanimitas to graduating medical students between 1932 and 1953. Bibliophiles have considered these volumes identical. However, there were at least seven different printings in English and one in Spanish and one in Portuguese. The size of the book and type of paper changed over the years. The title page, spine information, and printing information also changed. A congratulatory letter from Eli Lilly and Company was placed in the front of each book. These letters have many differences. Thus, the volumes are not identical and the recognition of these differences opens a new field for research and collecting.

Pemetrexed disodium (Eli Lilly).

Science.gov (United States)

Norman, P

2001-11-01

Pemetrexed, a thymidylate synthase (TS) and transferase inhibitor, is in phase III trials with Eli Lilly as a potential treatment for several common solid tumors, including non-small cell lung cancer (NSCLC) and mesothelioma [321789], [410731]. Studies on pemetrexed have concluded that not only is the compound a TS inhibitor but also a potent inhibitor of human dihydrofolate reductase (DHFR). The results suggest that pemetrexed acts upon multiple intracellular targets and that the antitumor effect may be derived from its simultaneous inhibition of multiple folate-requiring enzymes [203662]: this compound has been designated as a multitargeted antifolate (MTA) [386680]. The drug also causes concentration- and time-dependent apoptosis [284380]. Other studies in which the 4-oxo group of the pyrimidine ring portion of pemetrexed was replaced with a hydrogen atom, demonstrated that the resulting analogs were potent DHFR inhibitors with very little activity against the enzymes glycinamide ribonucleotide formyltransferase (GARFT) and TS [310674]. In phase II European studies in 64 patients with advanced breast cancer, encouraging responses were seen in anthracycline-failure (23%) and anthracycline-refractory (19%) patients. Responses were observed in 28% of patients who had been previously treated with a taxane [326097]. Data from a phase II trial of pemetrexed (500 mg/m2 once every 21 days as a 10 min i.v. infusion) as a salvage therapy in advanced breast cancer showed that supplementation of the treatment regime with folic acid (FA) and vitamin B12 reduced its already manageable and tolerable toxicities [408821], [409650]. At doses of 500 mg/m2, the drug was also safely administered to 35 patients with impaired renal function [409953]. Phase I and II trials have shown that the main side effects include neutropenia, thrombocytopenia, mucositis, nausea and vomiting [203666], [272241]. Princeton University holds the patent rights to this drug under EP-00432677. In June

The development of molecularly targeted anticancer therapies: an Eli Lilly and Company perspective.

Science.gov (United States)

Perry, William L; Weitzman, Aaron

2005-03-01

The ability to identify activated pathways that drive the growth and progression of cancer and to develop specific and potent inhibitors of key proteins in these pathways promises to dramatically change the treatment of cancer: A patient's cancer could be characterized at the molecular level and the information used to select the best treatment options. The development of successful therapies not only requires extensive target validation, but also new approaches to evaluating drug efficacy in animal models and in the clinic compared to the development of traditional cytotoxic agents. This article highlights Eli Lilly and Company's approach to developing targeted therapies, from target identification and validation through evaluation in the clinic. A selection of drugs in the Lilly Oncology pipeline is also discussed.

Indian Country Leaking Underground Storage Tanks (LUST) Map Service, Region 9, 2016, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — This map service displays Leaking Underground Storage Tanks in US EPA Region 9 Indian Country. The service is composed of three layers; one for each unique LUST...

The MULTIMEDIA exposure model as a risk assessment tool at LUST sites

International Nuclear Information System (INIS)

Bowers, R.B.

1994-01-01

In the course of characterizing Leaking Underground Storage Tank (LUST) sites in the Commonwealth, Virginia Department of Environmental Quality (VDEQ) regulations section 6.5.A.2.b of VR-680-13-02, requires that a risk assessment be performed which must address, among other issues, aqueous phase contaminant exposure levels to critical receptors. often, during the course of conducting such an assessment, the aqueous phase contaminant plume has not yet intercepted the critical down gradient receptor. Thus, the determination of the maximum potential exposure level to this receptor can only be made through the use of an appropriate fate and transport model. This paper focuses on an application of the saturated zone module of the USEPA's MULTIMEDIA Exposure Assessment model. The case study presented involves a LUST site in the Commonwealth, in which four critical receptors of leaded gasoline contaminated groundwater were identified. These receptors included three residential water wells and an intermittent stream. At this particular site, the aqueous phase contaminant plume had not yet reached any of the receptors; and the MULTIMEDIA model was employed to predict the steady-state aqueous phase concentrations with very favorable results

Duloxetine Eli Lilly.

Science.gov (United States)

Anttila, Sami; Leinonen, Esa

2002-08-01

Duloxetine is a serotonin (5-HT) and norepinephrine (NE) uptake inhibitor in pre-registration for depression. In vivo studies demonstrate that duloxetine inhibits 5-HT and NE transporters and this may induce an antidepressant effect [159168]. In humans, duloxetine has a low affinity for most 5-HT subtypes and for muscarinic, histamine H1, alpha1-adrenergic, alpha2-adrenergic and dopamine D2 receptors [444103]. Thus, it is not surprising that the meta-analysis of four recent clinical studies suggests duloxetine is a potent and well-tolerated antidepressant [429723]. By December 2001, Lilly had filed an NDA for depression. The launch of duloxetine is planned for the second half of 2002 [434250], [436220]. In April 2002, filing for stress urinary incontinence was anticipated for later in 2002 [456894]. Analysts at Banc of America predicted in April 2002, that the drug will be launched in the first quarter of 2003. The company projects US $400 million in revenue in 2003 and anticipates duloxetine to reach peak sales of over US $1 billion [450920]. Analysts at Morgan Stanley, projected US $25 million in sales in the fourth quarter 2002, rising to US $900 million in 2006 [450937]. At the same time, Credit Suisse First Boston anticipated launch for late 2002, with US $220 million in duloxetine revenues in 2003 and US $457 million in 2004 [450936].

John Lilly, The Mind of the Dolphin, and Communication Out of Bounds

Directory of Open Access Journals (Sweden)

Bruce Clarke

2014-09-01

Full Text Available In this essay I develop a systems-theoretical observation of John Lilly’s cybernetics of communication in his 1967 work The Mind of the Dolphin. The eight-year-old project that The Mind of the Dolphin recounts for public consumption details his aspiration to achieve an unprecedented breakthrough beyond companionate communion to fully abstract linguistic communication across species boundaries. Between 1959 and 1968 Lilly wagered and lost his mainstream scientific career largely over this audacious, ultimately inconclusive bid to establish and document for scientific validation “communication with a nonhuman mind.” In that effort, however, he mobilized the best available tools, a cutting-edge array of cybernetic concepts. He leaned heavily on the information theory bound up with first-order cybernetics and operated with heuristic computational metaphors alongside the actual computers of his era. As I will elicit through some close readings of his texts, in that process Lilly also homed in on crucial epistemological renovations with a constructivist redescription of cognition that may have influenced and motivated his colleague Heinz von Foerster’s more renowned formulations, arriving in the early 1970s, of a second-order cybernetics.

LEAK AND GAS PERMEABILITY TESTING DURING SOIL-GAS SAMPLING AT HAL'S CHEVRON LUST SITE IN GREEN RIVER, UTAH

Science.gov (United States)

The results of gas permeability and leak testing during active soil-gas sampling at Hal’s Chevron LUST Site in Green River, Utah are presented. This study was conducted to support development of a passive soil-gas sampling method. Gas mixtures containing helium and methane were...

MAAGs (Medical Audit Advisory Groups): the Eli Lilly National Clinical Audit Centre.

Science.gov (United States)

Baker, R; Fraser, R

1993-01-01

Outlines the framework for promoting audit in general practice, created as one part of the health service reforms. Medical Audit Advisory Groups (MAAGs) were set up in each district with the aim of participation in audit of all general practitioners by April 1992. The activities undertaken have included those recommended by the Department of Health; the most significant of these being the appointment of lay facilitators who are able to assist general practitioners and primary care teams co-operate over efforts to improve the quality of care, and may offer one means of introducing some of the methods of total quality management into general practice. Discusses the problems which remain: audit is not yet sufficiently systematic, interface audit with secondary care is at a very early stage, the ways to involve managers and patients in audit remain to be clarified, and there is little evidence of the consequences of audit in terms of improved care. The Eli Lilly National Clinical Audit Centre has been set up within the Department of General Practice, University of Leicester, in order to address these issues.

La economía de goce en el fetichismo y la adicción: The economy lust in fetichism and addiction

Directory of Open Access Journals (Sweden)

Deborah Fleischer

2010-12-01

Full Text Available En la clínica el objeto adictivo toma, muchas veces y en apariencia, la modalidad del objeto fetiche. Sin embargo las particularidades del mismo demuestran que hay una diferencia. El carácter compulsivo lleva a otra lógica aunque comparta un lugar común. El presente trabajo tiene como fin establecer cuales son las diferencias y singularidades que se pueden encontrar entre fetiche y objeto de consumo desde la economía de goce.In the clinic the addictive object takes, several times and apparently, the form of the fetish object. However, its peculiarities show that there is a diference. The compulsive character leads to another logic, even though it shares a common place. The present paper has its main aim to establish which are the differences and singularities that can be found between the fetish and the object of consumption, focusing on the lust economy.

Plasma levels of d1-3-(1,1-dimethylheptyl)-6,6aβ,7,8,10,10aα-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one (Lilly 109514) by quantitative mass fragmentography

International Nuclear Information System (INIS)

Sullivan, H.R.; Kau, D.L.K.; Wood, P.G.

1975-01-01

Lilly compound 109514 produces alterations in behavioral parameters in laboratory animals. Its relaxant and sedative properties are being studied clinically. A quantitative mass fragmentography (QMF) method for Lilly 109514 has been developed which is sensitive to 2 pmoles/4 ml sample. A similar assay has been developed for the major metabolite (formed by reduction of the 9-keto group). Both assays use deuterium labeled internal standards. Plasma concentrations of the parent drug and the metabolite were determined in dogs following oral administration of single and multiple 400 μg/kg doses of Lilly 109514. Results indicated the drug to be rapidly absorbed and metabolized in this species. Concentrations of the metabolite were significantly higher than those of the parent drug. These results implied that multiple-dosing of Lilly 109514 did not cause induction of metabolizing enzymes or other alterations of the metabolic process in the dog. Determination of the plasma concentrations of the parent drug and metabolite following i.v. administration have permitted the calculation of bioavailability and absorption data. The ability to follow plasma levels for 48 hours after a single i.v. administration of 100 μg/kg of 109514 graphically illustrates the value of quantitative mass fragmentography in kinetic studies of cannabinoids

VizieR Online Data Catalog: The Canada-France Redshift Survey (CFRS) (Lilly+, 1995)

Science.gov (United States)

Lilly, S. J.; Le Fevre, O.; Crampton, D.; Hammer, F.; Tresse, L.

2001-11-01

The Canada-France Redshift Survey (CFRS) is a collaboration between astronomers in Canada and France: Simon Lilly (University of Toronto), Olivier Le Fevre and Francois Hammer (Observatoire de Paris Meudon), David Crampton (Dominion Astrophysical Observatory, Victoria), Laurence Tresse (Cambridge University), and David Schade and Dan Hudon (University of Toronto). The survey is based primarily on observations with the 3.6m Canada-France-Hawaii Telescope (CFHT) on Mauna Kea, Hawaii. The CFRS consists of spectra of over 1000 faint objects selected to have 17.5 study of normal galaxies at redshifts z > 0.5, corresponding to look-back times of greater than 50% of the age of the Universe. Observations of CFRS galaxies have also been made with the Hubble Space Telescope and the survey will form the basis of future studies with a number of other ground-based and space facilities. We have written a lay-persons guide to the CFRS and the main scientific results that are emerging from it. (1 data file).

"One-night stands" - risky trips between lust and trust: qualitative interviews with Chlamydia trachomatis infected youth in North Sweden.

Science.gov (United States)

Christianson, Monica; Johansson, Eva; Emmelin, Maria; Westman, Göran

2003-01-01

The aim of the study was to get a deeper understanding of sexual risk-taking, by interviewing young people diagnosed with Chlamydia trachomatis. This qualitative study was conducted at a youth clinic in Umeå, Sweden. Five young women and four men, aged 18-22, participated. In-depth interviews were performed. Open questions around certain themes were posed, such as thoughts about getting CT, sexual encounters, and attitudes towards condoms. Interviews were tape-recorded and transcribed verbatim. Data were analysed according to grounded theory. Norms, events, and emotions were explored. The goal was to develop credible and applicable concepts concerning sexual relationships, risk-taking, and experiences of CT. Informants revealed that behind their sexual risk-taking was a drive to "go steady". Lust and trust were the guidelines if sex was going to take place. When discussing "one-night stands" gender stereotypes occurred. Females were expected to be less forward compared with males. We found an uneven distribution of responsibility concerning condoms. Males expected females to be "condom promoters". By catching CT, females experienced guilt, while males felt content through knowing "the source of contamination". An important public health issue is to implement how males should play an equal part in reproductive health. General CT screening of males is one suggestion.

Eli Lilly and Company's bioethics framework for human biomedical research.

Science.gov (United States)

Van Campen, Luann E; Therasse, Donald G; Klopfenstein, Mitchell; Levine, Robert J

2015-11-01

Current ethics and good clinical practice guidelines address various aspects of pharmaceutical research and development, but do not comprehensively address the bioethical responsibilities of sponsors. To fill this void, in 2010 Eli Lilly and Company developed and implemented a Bioethics Framework for Human Biomedical Research to guide ethical decisions. (See our companion article that describes how the framework was developed and implemented and provides a critique of its usefulness and limitations.) This paper presents the actual framework that serves as a company resource for employee education and bioethics deliberations. The framework consists of four basic ethical principles and 13 essential elements for ethical human biomedical research and resides within the context of our company's mission, vision and values. For each component of the framework, we provide a high-level overview followed by a detailed description with cross-references to relevant well regarded guidance documents. The principles and guidance described should be familiar to those acquainted with research ethics. Therefore the novelty of the framework lies not in the foundational concepts presented as much as the attempt to specify and compile a sponsor's bioethical responsibilities to multiple stakeholders into one resource. When such a framework is employed, it can serve as a bioethical foundation to inform decisions and actions throughout clinical planning, trial design, study implementation and closeout, as well as to inform company positions on bioethical issues. The framework is, therefore, a useful tool for translating ethical aspirations into action - to help ensure pharmaceutical human biomedical research is conducted in a manner that aligns with consensus ethics principles, as well as a sponsor's core values.

Autobiograafia kui „tõe” diskursus: Lilli Suburgi „Minu saatusega võitluskäik”. Autobiography as the Discourse of “Truth”: Lilli Suburg’s Minu saatusega võitluskäik

Directory of Open Access Journals (Sweden)

Eve Annuk

2012-04-01

Full Text Available Lilli Suburg (1841-1923 is an author in Estonian literary and cultural history who is not well researched, though her literary output is sufficiently large and her manuscript heritage many-sided, casting light on the little known aspects of her work and activity. Suburg was active in very different fields: she is known as a writer, journalist, feminist and educator. Her literary work is diverse and prolific; she wrote short stories, children’s stories, journalistic texts as well as philosophical essays. In Suburg’s work the autobiographical element plays a significant role, so that we can say that throughout her whole life she wrote her own autobiography, albeit using different forms. In this article, I example specifically the autobiography written by Lilli Suburg (1841-1923 entitled Minu saatusega võitluskäik (My Fight is my Destiny (1914, with the aim of introducing the text to the modern reader and analysing its content and peculiarities. As the text was published almost a hundred years ago, it deserves to be read anew and given a fresh interpretation from a modern point of view. The text certainly adds some new aspects to understanding Lilli Suburg’s life and activity; in the article I will analyse how Suburg looks at herself and her life and the reasons why she chose to write an autobiography with a feminist emphasis. The autobiography was published in the magazine Naiste Töö ja Elu (Women’s Work and Life in 1914 and to date it is the first and only feminist autobiography in Estonia. As Suburg had been a contributor to the magazine since its foundation in 1911, it provided a forum where she was able to share her feminist ideas and worldview with the readers. The magazine’s readers were understanding and supportive of feminist ideas, and the magazine’s focus was on women’s issues and women’s interests, the contributors being the leading women of the time. In her autobiography Suburg gives an overview of her life

Mehr Last als Lust – Ein weiterer Sammelband zu „(Frauen-Körper“ More Encumbrance than Enjoyment

Directory of Open Access Journals (Sweden)

Paula-Irene Villa

2006-11-01

Full Text Available Dieser Band vereint acht heterogene Aufsätze zu „Lust und Last am eigenen Körper“ von Frauen. Alle Beiträge gehören zum Spektrum psychologischer Reflexion; die Themen reichen dabei von Sport über Kochen und Essen bis Schönheit, die Zugänge von Psychoanalyse über experimentelle Psychologie bis hin zu freier Assoziation auf der Grundlage klinisch-praktischer Arbeit. Ein roter Faden durch die Beiträge ist nicht erkennbar und so wirkt die Vielfalt beliebig. So unterschiedlich die Beiträge sind, so unterschiedlich ist auch ihre Qualität. Leider kommen einige Artikel über die unkritische Zusammenstellung anderer Arbeiten nicht hinaus, die meisten nehmen kaum Bezug auf das inzwischen breite und institutionalisierte Feld der (sozial- und kulturwissenschaftlichen Körperforschung. Doch haben manche Aufsätze interessante empirische Einblicke zu bieten, die zur weiteren Reflexion anregen, und einige wenige Beiträge sind so differenziert, dass sich mit ihnen weiterdenken und -forschen lässt. Insgesamt bereitet die Lektüre des Buches weder ‚Einsteiger/-innen‘ noch ‚Fortgeschrittenen‘ der wissenschaftlichen Beschäftigung mit (Frauen-Körpern Lust, sondern erweist sich – bis auf Ausnahmen, die allerdings auch in ausführlicherer Form anderenorts publiziert wurden – eher als Last. Ärgerlich und alles andere als argumentativ überzeugend ist darüber hinaus das in manchen Texten enthaltene, mehr oder minder explizit artikulierte, ‚Feminismus- bzw. Frauenforschungs-Bashing‘.This volume joins together eight heterogeneous essays by women under the theme “enjoyment and encumbrance of the body.” All of the contributions belong within the spectrum of psychological reflection; the themes range from sports, cooking and eating, and beauty, to the process of psychoanalysis, experimental psychology, and free-association based on clinical practice. The thread throughout the contributions remains indiscernible and thus the

Health Advocacy Organizations and the Pharmaceutical Industry: An Analysis of Disclosure Practices

Science.gov (United States)

Raveis, Victoria H.; Friedman, Anne; Rothman, David J.

2011-01-01

Health advocacy organizations (HAOs) are influential stakeholders in health policy. Although their advocacy tends to closely correspond with the pharmaceutical industry's marketing aims, the financial relationships between HAOs and the pharmaceutical industry have rarely been analyzed. We used Eli Lilly and Company's grant registry to examine its grant-giving policies. We also examined HAO Web sites to determine their grant-disclosure patterns. Only 25% of HAOs that received Lilly grants acknowledged Lilly's contributions on their Web sites, and only 10% acknowledged Lilly as a grant event sponsor. No HAO disclosed the exact amount of a Lilly grant. As highly trusted organizations, HAOs should disclose all corporate grants, including the purpose and the amount. Absent this disclosure, legislators, regulators, and the public cannot evaluate possible conflicts of interest or biases in HAO advocacy. PMID:21233424

Emotional states of love moderate the association between catecholamines and female sexual responses in the laboratory.

Science.gov (United States)

Dundon, Carolyn M; Rellini, Alessandra H

2012-10-01

Research suggests that there are three interrelated, yet distinct, emotion-motivation brain systems for human love (lust, romantic love, and attachment), each associated with a unique catecholaminergic and hormonal profile. Of interest for the current study are norepinephrine (NE) and dopamine (DA), which have a hypothesized connection with romantic love. As NE and DA are also known to facilitate sexual arousal, it is plausible that NE and DA may have a greater positive association with the sexual arousal responses of women in romantic love compared with women in lust. This study investigated if the effects of NE and DA activity on sexual arousal responses would differ depending on emotion-motivation state (Lust or Romantic). Physiological sexual arousal was assessed by photoplethysmography and subjective sexual arousal was assessed with a participant-controlled lever. Seventeen women were included in the Lust group and 29 in the Romantic group. All participants provided a urine sample (to assess NE and DA) and completed a psychophysiological assessment. Elevated NE was positively and significantly associated with greater subjective and physiological sexual arousal for the Lust group, but not for the Romantic group. Similarly, elevated DA was positively and significantly associated with greater subjective sexual arousal for the Lust group, but not for the Romantic group. The sexual arousal responses of women in the Lust group, but not in the Romantic group, were positively and significantly associated with elevated NE and DA. It is feasible that, when women are seeking a partner (Lust), NE and DA may facilitate attention toward sexually relevant stimuli. © 2012 International Society for Sexual Medicine.

Love is in the gaze: an eye-tracking study of love and sexual desire.

Science.gov (United States)

Bolmont, Mylene; Cacioppo, John T; Cacioppo, Stephanie

2014-09-01

Reading other people's eyes is a valuable skill during interpersonal interaction. Although a number of studies have investigated visual patterns in relation to the perceiver's interest, intentions, and goals, little is known about eye gaze when it comes to differentiating intentions to love from intentions to lust (sexual desire). To address this question, we conducted two experiments: one testing whether the visual pattern related to the perception of love differs from that related to lust and one testing whether the visual pattern related to the expression of love differs from that related to lust. Our results show that a person's eye gaze shifts as a function of his or her goal (love vs. lust) when looking at a visual stimulus. Such identification of distinct visual patterns for love and lust could have theoretical and clinical importance in couples therapy when these two phenomena are difficult to disentangle from one another on the basis of patients' self-reports. © The Author(s) 2014.

Indian Country Leaking Underground Storage Tanks, Region 9, 2016

Science.gov (United States)

This GIS dataset contains point features that represent Leaking Underground Storage Tanks in US EPA Region 9 Indian Country. This dataset contains facility name and locational information, status of LUST case, operating status of facility, inspection dates, and links to No Further Action letters for closed LUST cases. This database contains 1230 features, with 289 features having a LUST status of open, closed with no residual contamination, or closed with residual contamination.

Leaking Underground Storage Tank Sites in Iowa

Data.gov (United States)

Iowa State University GIS Support and Research Facility — Leaking Underground Storage Tank (LUST) sites where petroleum contamination has been found. There may be more than one LUST site per UST site.

Thanatology and self-fashioning in John Chrysostom's thirteenth

African Journals Online (AJOL)

2015-11-25

Nov 25, 2015 ... For an event so mutual among human beings, death is often quite difficult to express, let alone ..... that the rich eat, as Chrysostom so often complains, are often ... lust for wine, greed and sexual lust never find satisfaction.

76 FR 55110 - In the Matter of Certain Gemcitabine and Products Containing Same; Notice of Commission...

Science.gov (United States)

2011-09-06

..., 2011, based on a complaint filed by Eli Lilly and Company (``Lilly''). 76 FR 16445. The complaint.... (``Hansoh'') as respondents. On August 9, 2011, Lilly, Hospira, and Intas filed a joint motion to terminate... Hansoh filed a response supporting termination, but for different reasons than those advanced by Lilly...

77 FR 31722 - New Animal Drugs; Change of Sponsor; Estradiol; Estradiol Benzoate and Testosterone Propionate...

Science.gov (United States)

2012-05-30

..., Division of Eli Lilly & Co. DATES: This rule is effective May 30, 2012. FOR FURTHER INFORMATION CONTACT... this table to Elanco Animal Health, Division of Eli Lilly & Co., Lilly Corporate Center, Indianapolis...

Developing good scientific publishing practices: one pharmaceutical company's perspective.

Science.gov (United States)

Dowsett, Sherie A; Van Campen, Luann E; Bednar, Lisa A

2010-06-01

The scientific publishing practices of the pharmaceutical industry have been heavily criticized in recent years due to the inherent conflict of interest that arises when a pharmaceutical company publishes findings around its own drugs. Eli Lilly and Company ('Lilly') strives for transparency in its day-to-day activities, and, here, shares its principles, policies and practices on publishing "Lilly-sponsored" research. A conflict of interest does not necessarily equate to biased presentation of research findings, and operating a successful, for-profit business and maintaining a focus on improving the health of patients are not mutually exclusive goals. There is, however, potential for bias, and it is incumbent upon a for-profit to develop publication principles, policies and practices to address this. To this end, Lilly's Principles of Medical Research states that 'Lilly discloses publicly all medical research results that are important to patients, healthcare providers or payers--whether favorable or unfavorable to a Lilly product--in an accurate, objective, and balanced manner ...' The preparation of publications of Lilly-sponsored research involves close collaboration between external (i.e., academic or otherwise non-industry employees) and Lilly scientific researchers (including scientific writers), with both serving as authors. Lilly does not support 'ghost' or 'guest' authorship. Authorship is not just recognition of contribution but also public acknowledgement of responsibility for content, and all authors are expected to take an active role in developing the manuscript in line with the International Committee of Medical Journal Editors-based authorship requirements. This is agreed to by authors before the manuscript is started. Lilly provides external authors with access to the trial data for manuscript development. Lilly does not pay external authors for their involvement in manuscript development. Scientific writers at Lilly, often with advanced scientific

78 FR 44432 - New Animal Drugs; Change of Sponsor; Fentanyl; Iron Injection

Science.gov (United States)

2013-07-24

... for an NADA from Nexcyon Pharmaceuticals, Inc. to Elanco Animal Health, A Division of Eli Lilly & Co..., NADA 141-337 for RECUVYRA (fentanyl) Transdermal Solution to Elanco Animal Health, A Division of Eli Lilly & Co., Lilly Corporate Center, [[Page 44433

75 FR 9333 - Implantation or Injectable Dosage Form New Animal Drugs; Tilmicosin

Science.gov (United States)

2010-03-02

... (NADA) filed by Elanco Animal Health, A Division of Eli Lilly & Co. The supplemental NADA provides a...: [email protected] . SUPPLEMENTARY INFORMATION: Elanco Animal Health, A Division of Eli Lilly & Co., Lilly Corporate Center, Indianapolis, IN 46285, filed a supplement to NADA 140-929 for MICOTIL...

76 FR 16445 - In the Matter of Certain Gemcitabine and Products Containing Same; Notice of Investigation

Science.gov (United States)

2011-03-23

... Act of 1930, as amended, 19 U.S.C. 1337, on behalf of Eli Lilly and Company of Indianapolis, Indiana. Eli Lilly filed letters supplementing the complaint on February 9 and 16, 2011. The Commission requested additional information on March 2, 1011. Eli Lilly responded with additional information...

77 FR 46612 - New Animal Drugs; Change of Sponsor; Change of Sponsor Address; Azaperone; Miconazole, Polymyxin...

Science.gov (United States)

2012-08-06

... Pharmaceutica NV, to Elanco Animal Health, a Division of Eli Lilly & Co. FDA is also amending the animal drug..., polymyxin B sulfate, prednisolone acetate) Otic Suspension to Elanco Animal Health, a Division of Eli Lilly & Co., Lilly Corporate Center, Indianapolis, IN 46285. Following these changes of sponsorship, Janssen...

Lillie Martin in Gottingen. Lillie Martin, Outstanding Scholar and Teacher: A Centennial Symposium.

Science.gov (United States)

Adler, Helmut E.

This article reports on a symposium commemorating Lillien Martin's dissertation, "Analysis of Difference Sensations," by published in 1899. The symposium marked the centenary celebration in acknowledgement of Martin's pioneer efforts for women in the field of psychology. Psychophysics was concerned with the quantitative assessment of…

Rauno Pukonen : Meie toodangut armastatakse, meid endid mitte / Rauno Pukonen ; interv. Svea Talving

Index Scriptorium Estoniae

Pukonen, Rauno

2004-01-01

Farmaatsiafirmast Eli Lilly, ravimifirmade madalast mainest. Eli Lilly filiaali juhi sõnul ei lase väike turg ja tagasihoidlik kompensatsioon võimalikku ravimivalikut Eestisse tuua. Lisa: Fakte ettevõttest

Biblical Leadership: Insights for Today's Managers

OpenAIRE

Friedman, Hershey H.; Friedman, Linda

2004-01-01

The scholarly literature in management has paid little attention to the study of Biblical figures as leaders. This paper aims to advance the effort to fill this gap by demonstrating that many insights about successful and unsuccessful leadership may be derived from the Bible. Successful leaders demonstrated a willingness to be different, a passion for justice, humility, and a concern for others. Unsuccessful leaders were sidetracked from their mission by the hunger for power or by lust and envy.

Ainult 1%-meestest ei ole erektsioonihäire ravitav

Index Scriptorium Estoniae

2004-01-01

Erektsioonihäirete põhjustest, seotud haigustest ja ravimeetoditest rääkisid ravimifirma Eli Lilly korraldatud loengupäeval uroloog Margus Punab, kardioloog Arvo Rosenthal, psühhiaater Imre Rammul ja Eli Lilly turundusjuht Katrin Lätt

Rauno Pukonen : Turule tulevad vaid oma klassi parimad rohud / Rauno Pukonen ; interv. Vilve Torn

Index Scriptorium Estoniae

Pukonen, Rauno

2006-01-01

Rahvusvahelise Ravimitootjate Liidu juhatuse esimees ja Eli Lilly Balti regiooni direktor vastab küsimustele, mis puudutavad innovatiivsusest ja kvaliteedist lähtumise põhimõtet ravimitootmises, ravimihindade teket, firma 70 miljoni dollari suurust toetust tuberkuloosiprogrammile, firma tulevikku. Lisad: Eli Lilly & Co 130; Ajalugu

'Szhigaja eti kulturnõje mostõ...' : Moskva-Tallinn 1958-1986 / Vera Ruber

Index Scriptorium Estoniae

Ruber, Vera, 1925-2011

1997-01-01

Tööst eesti kirjanduse konsultandina Üleliidulise Kirjanike Liidu juhatusse sekretariaadis. Ka 1959. a. romaanivõistlusel silmapaistnud romaanidest (Lilli Prometi 'Meesteta küla' ja Raimond Kaugveri 'Võõra mõõga teenistuses'), Lilli Prometi romaanist 'Primavera' ja venekeelsest kogumikust 'Eesti noor proosa' (1978)

UST/LUST Site Information

Data.gov (United States)

U.S. Environmental Protection Agency — This asset contains all Underground Storage Tank (UST) site information. It includes details such as property location, acreage, identification and characterization,...

Witz, Lust und Aggression

DEFF Research Database (Denmark)

Rösing, Lilian Munk

2014-01-01

Artiklen beskæftiger sig med forholdet mellem vits, lyst og aggression med udgangspunkt i lysten ved aggressiv litterær humor, eksemplificeret ved tekststeder fra Shakespeares Hamlet. Der argumenteres for, at aggressionen eller angrebet er et fælles centralt aspekt ved Sigmund Freuds og Friedrich...

Orally disintegrating olanzapine review: effectiveness, patient preference, adherence, and other properties

Directory of Open Access Journals (Sweden)

Montgomery W

2012-02-01

Full Text Available William Montgomery1, Tamas Treuer2, Jamie Karagianis3, Haya Ascher-Svanum4, Gavan Harrison51Global Health Outcomes, Eli Lilly and Company, Sydney, Australia; 2Emerging Markets Business Unit (Neuroscience, Eli Lilly and Company, Budapest, Hungary; 3Eli Lilly and Company, Indianapolis, IN, USA; 4Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN, USA; 5Asia-Pacific Medical Communications, Eli Lilly and Company, Sydney, AustraliaAbstract: Orally disintegrating olanzapine (ODO is a rapid-dissolving formulation of olanzapine which disintegrates in saliva almost immediately, developed as a convenient and adherence-enhancing alternative to the standard olanzapine-coated tablet (SOT. Clinical studies, which form the basis of this review, have shown ODO and SOT to have similar efficacy and tolerability profiles. However, ODO appears to have a number of advantages over SOT in terms of adherence, patient preference, and reduction in nursing burden. Overall, the existing clinical data suggests that compared to SOT, ODO is not only well-suited for difficult-to-treat, agitated, and/or nonadherent patients but, due to its potential ability to improve adherence and greater patient preference, may also be an appropriate formulation for the majority of patients for which olanzapine is the antipsychotic of choice.Keywords: orodispersible formulation, orally disintegrating, olanzapine, atypical antipsychotics, patient adherence, preference, schizophrenia, bipolar disorder

Commitment to leakless pumps

International Nuclear Information System (INIS)

Locheed, T.

1993-01-01

The landscape has changed radically in recent years. Not too long ago, Eli Lilly and Co.'s Clinton Laboratories plant in Clinton, IN, buried its solvent storage tanks because the company's insurer required the practice. At the time, tank burial was considered the safest way to handle the solvents. One of the materials stored in those tanks, methylene chloride (or dichloromethane, DCM), was considered a virtual godsend: it was clean, safe and inexpensive. More recently, DCM has acquired a tarnished reputation and a place on the EPA's most wanted list because of its extensive use in the United States (the EPA also regulates other solvents that Lilly uses, including acetone, toluene and methanol). As well as taking aim at fugitive emissions, more properly known as equipment leaks, the Clean Air Act Amendments specify that companies cannot store such chemicals underground in single-wall tanks any longer; secondary containment is the order of the day

Atomoxetine Open-Label Trial in ADHD

Directory of Open Access Journals (Sweden)

J Gordon Millichap

2002-07-01

Full Text Available Atomoxetine (originally named tomoxetine, a new therapy for attention deficit hyperactivity disorder (ADHD marketed by Eli Lilly, was compared to methylphenidate in a prospective, randomized, open-label study for 10 weeks duration, at the University of Nebraska Medical Center, Massachusetts General Hospital, Mount Sinai Medical Center, Carolinas Medical Center, and Lilly Research Laboratories.

Clinical development of galunisertib (LY2157299 monohydrate, a small molecule inhibitor of transforming growth factor-beta signaling pathway

Directory of Open Access Journals (Sweden)

Herbertz S

2015-08-01

Full Text Available Stephan Herbertz,1 J Scott Sawyer,2 Anja J Stauber,2 Ivelina Gueorguieva,3 Kyla E Driscoll,4 Shawn T Estrem,2 Ann L Cleverly,3 Durisala Desaiah,2 Susan C Guba,2 Karim A Benhadji,2 Christopher A Slapak,2 Michael M Lahn21Lilly Deutschland GmbH, Bad Homburg, Germany; 2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 3Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK; 4Lilly Research Laboratories, Eli Lilly and Company, New York, NY, USA Abstract: Transforming growth factor-beta (TGF-β signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks of cancer, including tumor proliferation, invasion and metastasis, inflammation, angiogenesis, and escape of immune surveillance. There are several pharmacological approaches to block TGF-β signaling, such as monoclonal antibodies, vaccines, antisense oligonucleotides, and small molecule inhibitors. Galunisertib (LY2157299 monohydrate is an oral small molecule inhibitor of the TGF-β receptor I kinase that specifically downregulates the phosphorylation of SMAD2, abrogating activation of the canonical pathway. Furthermore, galunisertib has antitumor activity in tumor-bearing animal models such as breast, colon, lung cancers, and hepatocellular carcinoma. Continuous long-term exposure to galunisertib caused cardiac toxicities in animals requiring adoption of a pharmacokinetic/pharmacodynamic-based dosing strategy to allow further development. The use of such a pharmacokinetic/pharmacodynamic model defined a therapeutic window with an appropriate safety profile that enabled the clinical investigation of galunisertib. These efforts resulted in an intermittent dosing regimen (14 days on/14 days off, on a 28-day cycle of galunisertib for all ongoing trials. Galunisertib is being investigated either as monotherapy or in combination with standard antitumor regimens (including nivolumab

Transition et amélioration des indices mondiaux de philanthropie ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana. Ce projet vise principalement sur l'inclusion des pays à économie émergente. La Lilly Family School ...

Schuldnerfalle Suchmaschinen-Cache / Patrick Sakowski

Index Scriptorium Estoniae

Sakowski, Patrick

2016-01-01

Otsingumootorite vahemällu salvestatud andmete kustutamisest (nt kõlvatu konkurentsi või autoriõiguste rikkumisesga seotud kustutatud andmete kustutamine ka vahemälust, et otsingu tulemus ei viitaks kustutatud infole)

The Lean Enterprise - A Management Philosophy at Lockheed Martin

National Research Council Canada - National Science Library

Joyce, Michael; Schechter, Bettina

2004-01-01

... performance, Leaders soon realized that best practice sharing was lust one means to a higher end, The ultimate goal is to create a system that consistently achieves excellence for our customers, shareholders...

Tribal UST and LUST Data

Data.gov (United States)

U.S. Environmental Protection Agency — Subtitle I of the Resource Conservation and Recovery Act, as amended by the Hazardous Waste Disposal Act of 1984, brought underground storage tanks (USTs) under...

Spatio-temporal dynamics of the mirror neuron system during social intentions.

Science.gov (United States)

Cacioppo, Stephanie; Bolmont, Mylene; Monteleone, George

2017-10-27

Previous research has shown that specific goals and intentions influence a person's allocation of social attention. From a neural viewpoint, a growing body of evidence suggests that the inferior fronto-parietal network, including the mirror neuron system, plays a role in the planning and the understanding of motor intentions. However, it is unclear whether and when the mirror neuron system plays a role in social intentions. Combining a behavioral task with electrical neuroimaging in 22 healthy male participants, the current study investigates whether the temporal brain dynamic of the mirror neuron system differs during two types of social intentions i.e., lust vs. romantic intentions. Our results showed that 62% of the stimuli evoking lustful intentions also evoked romantic intentions, and both intentions were sustained by similar activations of the inferior frontal gyrus and the inferior parietal lobule/angular gyrus for the first 432 ms after stimulus onset. Intentions to not love or not lust, on the other hand, were characterized by earlier differential activations of the inferior fronto-parietal network i.e., as early as 244 ms after stimulus onset. These results suggest that the mirror neuron system may not only code for the motor correlates of intentions, but also for the social meaning of intentions and its valence at both early/automatic and later/more elaborative stages of information processing.

Different insulin concentrations in resuspended vs. unsuspended NPH insulin: Practical aspects of subcutaneous injection in patients with diabetes.

Science.gov (United States)

Lucidi, P; Porcellati, F; Marinelli Andreoli, A; Candeloro, P; Cioli, P; Bolli, G B; Fanelli, C G

2017-06-06

This study measured the insulin concentration (Ins [C] ) of NPH insulin in vials and cartridges from different companies after either resuspension (R+) or not (R-; in the clear/cloudy phases of unsuspended NPH). Measurements included Ins [C] in NPH(R+) and in the clear/cloudy phases of NPH(R-), and the time needed to resuspend NPH and time for NPH(R+) to separate again into clear/cloudy parts. In vials of NPH(R+) (assumed to be 100%), Ins [C] in the clear phase of NPH(R-) wasEli Lilly NPH, respectively. Likewise, in pen cartridges, Ins [C] in the clear phase of NPH(R-) wasLilly and Sanofi NPH. Time needed to resuspend NPH (spent in tipping) in vials was brief with both Novo (5±1s) and Lilly NPH (6±1s), but longer with all pen cartridges (50±8s, 40±6s and 30±4s from Novo, Lilly and Sanofi, respectively; P=0.022). Time required for 50% separation into cloudy and clear parts of NPH was longer with Novo (60±7min) vs. Lilly (18±3min) in vials (P=0.021), and affected by temperature, but not by the different diameter sizes of the vials. With pen cartridges, separation into clear and cloudy parts was significantly faster than in vials (P<0.01). Ins [C] in NPH preparations varies depending on their resuspension or not. Thus, subcutaneous injection of the same number of units of NPH in patients with diabetes may deliver different amounts of insulin depending on its prior NPH resuspension. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Tamula rannaala ideevõistluse võitis lustakas nägemus

Index Scriptorium Estoniae

2008-01-01

Võistlusele esitatud tööde näitus Võrumaa Muuseumis. Preemiasaajate nimed. Võidutöö nimetusega "Lust" autor on K. Enno Arhitektuuribüroo koosseisus Kaie Enno, Leles Luhse, Maria Zeleznova ja Rein Ailt

Mõnda Eesti kirjanduselust Moskva vaatevinklist (1958-1986) : [mälestusi ja päevikumärkmeid aastaist 1968-1969] / Vera Ruber

Index Scriptorium Estoniae

Ruber, Vera, 1925-2011

1997-01-01

Tööst eesti kirjanduse konsultandina Üleliidulise Kirjanike Liidu juhatuse sekretariaadis. Ka 1959. a. romaanivõistlusel silmapaistnud romaanidest (Lilli Prometi "Meesteta küla" ja Raimond Kaugveri "Võõra mõõga teenistuses"), Lilli Prometi romaanist "Primavera" ja venekeelsest kogumikust "Eesti noor proosa" ("Эстонская молодая проза", koost. Endel Mallene ja Rein Saluri, 1978)

[Communication in the early modern Baltic Sea region = Kommunikatsioon varauusaegses Läänemereruumis] / Ulrike Plath

Index Scriptorium Estoniae

Plath, Ulrike, 1972-

2011-01-01

Arvustus: Communication in the early modern Baltic Sea region = Kommunikatsioon varauusaegses Läänemereruumis. Hrsg. von Enn Küng, Mati Laur, Kersti Lust. Ajalooline Ajakiri. The Estonian Historical Journal 2009. Nr. 3/4 (129/130). (Tartu 2010)

Project transition to risk based corrective action

International Nuclear Information System (INIS)

Judge, J.M.; Cormier, S.L.

1996-01-01

Many states have adopted or are considering the adoption of the America Society for Testing and Materials (ASTM) Standard E 1739, Standard for Risk Based Corrective Action (RBCA) Applied to Petroleum Release Sites. This standard is being adopted to regulate leaking underground storage tank (LUST) sites. The case studies of two LUST sites in Michigan will be presented to demonstrate the decision making process and limiting factors involved in transitioning sites to the RBCA program. Both of these case studies had been previously investigated and one was actively remediated. The first case study involves a private petroleum facility where soil and ground water have been impacted. Remediation involved a ground water pump and treat system. Subsequent monitoring during system operation indicated that analytical data were still above the Tier 1 RBSLs but below the Tier 2 SSTLs. The closure strategy that was developed was based on the compounds of concern that were below the SSTLs. A deed restriction was also developed for the site as an institutional control. The second LUST site exhibited BTEX concentrations in soil and ground water above the Tier 1 RBSLs. Due to the exceedence of the Tier 1 RBSLs, the second site required a Tier 2 assessment to develop SSTLs as remedial objectives and remove hot spots in the soil and treat the ground water to achieve closure. Again, a deed restriction was instituted along with a performance monitoring plan

Eesti tippteadlaste panus maailma : päästvad bakterid ja täiustatud elektroonika / koost. Jüri Allik

Index Scriptorium Estoniae

2007-01-01

Jüri Allik lappas maailma suurimat teaduskirjanduse andmebaasi ISI Web of Science. Enimviidatud Eesti teadlased on: Jaan Aarik, Jaak Jürimäe, Mati Karelson, Marco Kirm, Eero Vasar, Mihkel Zilmer, Ülo Niinemets, Kaupo Kukli, Enn Lust

Identifying Emotions on the Basis of Neural Activation.

Science.gov (United States)

Kassam, Karim S; Markey, Amanda R; Cherkassky, Vladimir L; Loewenstein, George; Just, Marcel Adam

2013-01-01

We attempt to determine the discriminability and organization of neural activation corresponding to the experience of specific emotions. Method actors were asked to self-induce nine emotional states (anger, disgust, envy, fear, happiness, lust, pride, sadness, and shame) while in an fMRI scanner. Using a Gaussian Naïve Bayes pooled variance classifier, we demonstrate the ability to identify specific emotions experienced by an individual at well over chance accuracy on the basis of: 1) neural activation of the same individual in other trials, 2) neural activation of other individuals who experienced similar trials, and 3) neural activation of the same individual to a qualitatively different type of emotion induction. Factor analysis identified valence, arousal, sociality, and lust as dimensions underlying the activation patterns. These results suggest a structure for neural representations of emotion and inform theories of emotional processing.

Clinical utility of orally disintegrating olanzapine in Chinese patients with schizophrenia: a review of effectiveness, patient preference, adherence, and other properties

Directory of Open Access Journals (Sweden)

Zhao J

2014-02-01

Full Text Available Jingping Zhao,1 Jianjun Ou,1 Haibo Xue,2 Li Liu,2 William Montgomery,3 Tamas Treuer4 1Mental Health Institute of The Second Xiangya Hospital, Hunan Province Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 2Lilly Suzhou Pharmaceutical Co, Ltd, Jiangsu, People's Republic of China; 3Global Health Outcomes, Eli Lilly and Company, Sydney, Australia; 4Emerging Markets Business Unit (Neuroscience, Eli Lilly and Company, Budapest, Hungary Abstract: The primary objective of this systematic review was to examine the evidence for the efficacy, effectiveness, and safety of orally disintegrating olanzapine in Chinese populations. A systematic literature search was conducted using databases covering international and Chinese journals, ClinicalTrials.gov, and internal and external trial registries at Eli Lilly and Company using search terms related to target countries (People's Republic of China, Hong Kong, and Taiwan and orally disintegrating olanzapine treatment. A publication and one clinical study report were retrieved. The clinical study showed orally disintegrating olanzapine and the standard oral tablet to have similar efficacy and tolerability profiles. A bioequivalence study has shown that orally disintegrating olanzapine and the standard oral tablet have similar pharmacokinetic profiles. Orally disintegrating olanzapine and the standard oral tablet have similar efficacy and tolerability profiles. Keywords: orally disintegrating, olanzapine, Chinese, schizophrenia, patients

Tamula rannaala planeering = Competition of spatial planning of the Tamula lakeside area, Võru / Dace Kalvane

Index Scriptorium Estoniae

Kalvane, Dace

2008-01-01

Žürii liige Võru Tamula järve rannaala mahulise planeeringu rahvusvahelisest ideekonkursist, auhinnatud töödest. Võidutöö "Lust" autorid on Kaie Enno, Leles Luhse, Maria Zeleznova ja Rein Ailt (Kaie Enno Arhitektuuribüroo)

AIMES Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Katz, Daniel S [Univ. of Illinois, Urbana-Champaign, IL (United States). National Center for Supercomputing Applications (NCSA); Jha, Shantenu [Rutgers Univ., New Brunswick, NJ (United States); Weissman, Jon [Univ. of Minnesota, Minneapolis, MN (United States); Turilli, Matteo [Rutgers Univ., New Brunswick, NJ (United States)

2017-01-31

This is the final technical report for the AIMES project. Many important advances in science and engineering are due to large-scale distributed computing. Notwithstanding this reliance, we are still learning how to design and deploy large-scale production Distributed Computing Infrastructures (DCI). This is evidenced by missing design principles for DCI, and an absence of generally acceptable and usable distributed computing abstractions. The AIMES project was conceived against this backdrop, following on the heels of a comprehensive survey of scientific distributed applications. AIMES laid the foundations to address the tripartite challenge of dynamic resource management, integrating information, and portable and interoperable distributed applications. Four abstractions were defined and implemented: skeleton, resource bundle, pilot, and execution strategy. The four abstractions were implemented into software modules and then aggregated into the AIMES middleware. This middleware successfully integrates information across the application layer (skeletons) and resource layer (Bundles), derives a suitable execution strategy for the given skeleton and enacts its execution by means of pilots on one or more resources, depending on the application requirements, and resource availabilities and capabilities.

Poetics of Resistance in Roman Antiquity: A Reading in Neronian ...

African Journals Online (AJOL)

ANDCORPgh changing the world

had considerable influence on his satires, which have been variously seen as obscure, ..... Juvenal was another fire-brand critic of the Neronian regime, known for his .... viewed luxury and lust as cognate vices so that those prone to sexual ...

Factors associated with early response to olanzapine and clinical and functional outcomes of early responders treated for schizophrenia in the People’s Republic of China

Directory of Open Access Journals (Sweden)

Ye W

2014-05-01

Full Text Available Wenyu Ye,1 William Montgomery,2 Zbigniew Kadziola,3 Li Liu,4 Haibo Xue,4 Michael D Stensland,5 Tamas Treuer61Real World Analytics, Eli Lilly and Company, Indianapolis, IN, USA; 2Global Patient Outcomes and Real World Evidence, Eli Lilly Australia Pty Ltd, West Ryde, Australia; 3Real World Analytics Capabilities, Eli Lilly GmbH, Vienna, Austria; 4Lilly Suzhou Pharmaceutical Co, Ltd, Shanghai Branch, People’s Republic of China; 5Agile Outcomes Research, Inc., Rochester, MN, USA; 6Neuroscience Research, Eli Lilly and Company, Budapest, HungaryBackground: The aims of this analysis were to identify factors associated with early response (at 4 weeks to olanzapine treatment and to assess whether early response is associated with better longer-term outcomes for patients with schizophrenia in the People’s Republic of China.Methods: A post hoc analysis of a multi-country, 6-month, prospective, observational study of outpatients with schizophrenia or bipolar mania who initiated or switched to treatment with oral olanzapine was conducted using data from the Chinese schizophrenia subgroup (n=330. Factors associated with early response were identified using a stepwise logistic regression with baseline clinical characteristics, baseline participation in a weight control program, and adherence with antipsychotics during the first 4 weeks of treatment. Mixed models for repeated measures with baseline covariates were used to compare outcomes over time between early responders and early nonresponders to olanzapine.Results: One hundred and thirty patients (40% achieved an early response. Early response was independently predicted by higher baseline Clinical Global Impressions-Severity score (odds ratio [OR] 1.51, 95% confidence interval [CI] 1.15–1.97, fewer years since first diagnosis (OR 0.94, CI 0.90–0.98, a greater number of social activities (OR 1.22, CI 1.05–1.40, participation in a weight control program (OR 1.81, CI 1.04–3.15, and high adherence

Olemise arheoloog / Tanel Veenre

Index Scriptorium Estoniae

Veenre, Tanel, 1977-

2009-01-01

Pariisis elavast ja töötavast eesti kunstnikust Kaia Kiigest, kes jõudis filosoofiaõpingute kaudu maalimise juurde, tema maalinäitusest "Strata" Tallinnas galeriis Vaal 2.-21. aprillini. Kaia Kiik loomisprotsessist, sõnumist, keskkonnast, mälust, Eestist ja Pariisist

Identifying Emotions on the Basis of Neural Activation.

Directory of Open Access Journals (Sweden)

Karim S Kassam

Full Text Available We attempt to determine the discriminability and organization of neural activation corresponding to the experience of specific emotions. Method actors were asked to self-induce nine emotional states (anger, disgust, envy, fear, happiness, lust, pride, sadness, and shame while in an fMRI scanner. Using a Gaussian Naïve Bayes pooled variance classifier, we demonstrate the ability to identify specific emotions experienced by an individual at well over chance accuracy on the basis of: 1 neural activation of the same individual in other trials, 2 neural activation of other individuals who experienced similar trials, and 3 neural activation of the same individual to a qualitatively different type of emotion induction. Factor analysis identified valence, arousal, sociality, and lust as dimensions underlying the activation patterns. These results suggest a structure for neural representations of emotion and inform theories of emotional processing.

Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review

Directory of Open Access Journals (Sweden)

Treuer T

2016-05-01

Full Text Available Tamás Treuer,1 Luis Méndez,2 William Montgomery,3 Shenghu Wu4 1Neuroscience Research, Eli Lilly and Company, Budapest, Hungary; 2Eli Lilly de Mexico, Mexico City, Mexico; 3Global Patient Outcomes and Real World Evidence, Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 4Neuroscience Research, Eli Lilly Asia, Inc, Shanghai, People’s Republic of China Abstract: The purpose of this paper was to systematically review the literature related to research about the factors affecting treatment adherence and discontinuation of atomoxetine in pediatric, adolescent, and adult patients with attention-deficit/hyperactivity disorder (ADHD. Medline was systematically searched using the following prespecified terms: “ADHD”, “Adherence”, “Compliance”, “Discontinuation”, and “Atomoxetine”. We identified 31 articles that met all inclusion and exclusion criteria. The findings from this review indicate that persistence and adherence to atomoxetine treatment were generally high. Factors found to influence adherence and nonadherence to atomoxetine treatment in ADHD in this review include age, sex, the definition of response used, length of treatment, initial dose of treatment, comorbid conditions, and reimbursement. Tolerability was cited as an important reason for treatment discontinuation. More research is needed to understand those factors that can help to identify patients at risk for poor adherence and interventions that could improve treatment adherence early in the stage of this illness to secure a better long-term prognosis. Keywords: atomoxetine, treatment discontinuation, adherence, compliance, ADHD medication, relapse

Slapen: een lust of een last

NARCIS (Netherlands)

Coenen, A.M.L.; Allewijn, M; Miesen, H.M.L.

2006-01-01

Humans cannot live without sleep, but despite this important fact it is still not exactly known what the function of sleep precisely is. Probably, sleep plays a role in bodily recovery. Sleep is for restoration of the body, by the functioning of the anabolic growth hormone which is released during

The diverse aims of science.

Science.gov (United States)

Potochnik, Angela

2015-10-01

There is increasing attention to the centrality of idealization in science. One common view is that models and other idealized representations are important to science, but that they fall short in one or more ways. On this view, there must be an intermediary step between idealized representation and the traditional aims of science, including truth, explanation, and prediction. Here I develop an alternative interpretation of the relationship between idealized representation and the aims of science. I suggest that continuing, widespread idealization calls into question the idea that science aims for truth. If instead science aims to produce understanding, this would enable idealizations to directly contribute to science's epistemic success. I also use the fact of widespread idealization to motivate the idea that science's wide variety aims, epistemic and non-epistemic, are best served by different kinds of scientific products. Finally, I show how these diverse aims—most rather distant from truth—result in the expanded influence of social values on science. Copyright © 2015 Elsevier Ltd. All rights reserved.

17. RMJ Oduor Eternal Damnation, a Reply to Karori Mbugua's ...

African Journals Online (AJOL)

REGINALDS

doctrine of eternal damnation. I avoid using the term “hell”, preferring to use the ... Mbugua goes on to assert that an adequate theory of justice (he probably means. “theory of ..... gratification of lust and hatred and finally parts with the last rag of.

Children's Comprehension of Plural Predicate Conjunction

Science.gov (United States)

Tieu, Lyn; Romoli, Jacopo; Poortman, Eva; Winter, Yoad; Crain, Stephen

2018-01-01

Previous developmental studies of conjunction have focused on the syntax of phrasal and sentential coordination (Lust, 1977; de Villiers, Tager-Flusberg & Hakuta, 1977; Bloom, Lahey, Hood, Lifter & Fiess, 1980, among others). The present study examined the flexibility of children's interpretation of conjunction. Specifically, when two…

Do concomitant pain symptoms in patients with major depression affect quality of life even when taking into account baseline depression severity?

Directory of Open Access Journals (Sweden)

Novick D

2013-05-01

Full Text Available Diego Novick,1 William Montgomery,2 Zbigniew Kadziola,3 Victoria Moneta,4 Xiaomei Peng,5 Roberto Brugnoli,6 Josep Maria Haro41Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Eli Lilly Austria GmbH, Vienna, Austria; 4Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 5Eli Lilly and Company, Indianapolis, IN, USA; 6Università di Roma, “Sapienza,” Rome, ItalyBackground: Patients with major depressive disorder (MDD may suffer from concomitant pain symptoms. The aim of this study is to determine whether the presence of painful physical symptoms (PPS influences quality of life when taking into account baseline depression severity.Methods: Patients with a new or first episode of MDD (n = 909 were enrolled in a 3-month prospective observational study in East Asia. The Hamilton Depression Rating Scale, Clinical Global Impression-Severity score, Somatic Symptom Inventory, and EuroQoL questionnaire-5 Dimensions (EQ-5D and EQ-Visual Analogue Scale (EQ-VAS were assessed at baseline and 3 months’ follow-up. The presence of PPS was defined as a mean score of ≥2 on the Somatic Symptom Inventory pain-related items. Regression analyses determined predictors of quality of life at 3 months, adjusting for age, sex, depressive symptoms, overall severity, and quality of life at baseline.Results: PPS were present (PPS+ at baseline in 52% of patients. During the 3-month follow-up, EQ-VAS scores improved from 47.7 (standard deviation [SD] 20.6 to 72.5 (SD 20.4, and EQ-5D improved from 0.48 (SD 0.34 to 0.80 (SD 0.26. At 3 months, mean EQ-VAS was 66.4 (SD 21.2 for baseline PPS+ patients versus 78.5 (SD 17.6 for baseline PPS- patients, and mean EQ-5D was 0.71 (SD 0.29 versus 0.89 (SD 0.18. PPS+ at baseline was a significant predictor of quality of life at 3 months after adjusting for sociodemographic and baseline clinical variables

African Journal of AIDS Research - Vol 13, No 2 (2014)

African Journals Online (AJOL)

Love, lust and the emotional context of multiple and concurrent sexual partnerships among young Swazi adults · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Allison Ruark, Lunga Dlamini, Nonhlanhla Mazibuko, Edward C Green, Caitlin Kennedy, Amy Nunn, Timothy Flanigan, ...

Tšetšeenia - sõja lõppu ei paista / Aadu Hiietamm

Index Scriptorium Estoniae

Hiietamm, Aadu, 1954-

2005-01-01

Autori väitel on praegune olukord Tšetšeenias halvem kui 1999. aastal, maailma tähelepanu Tšetšeenias toimuvale on nõrgenenud. Vt. samas: Igor Taro. Ramzan Kadõrov: tapan elu lõpuni. Katrin Lust-Buchanan. Tšetšeenid armastavad vabadust

AIM Data Services

Directory of Open Access Journals (Sweden)

Michael Scholz

2016-05-01

Full Text Available AIM Data Services as a virtual facility provides virtual 3D reference tracks for simulation applications in the domain of automotive and railway systems. It offers tools for management and analysis of experiment data and a platform for survey and processing of vehicle data in the public transport domain. Collected spatial data is bundled in a database cluster and published through common web mapping interfaces.

Politics of Deceit and Reality in Africa: A Study of Joseph Edoki's ...

African Journals Online (AJOL)

These problems range from bribery and corruption by the political leaders and government officials, economic deprivation of the plebeians, the tendency to loot and embezzle government funds, the naked lust for power and wealth, the rigging and manipulation of election results, the killing, maiming and burning of political ...

ENTERPRISE RESTRUCTURING AIM AND TYPES

Directory of Open Access Journals (Sweden)

S. P. Baranenko

2011-01-01

Full Text Available Enterprise restructuring is aimed at adapting it to market conditions and improving its competitiveness through selection of most effective model of using material, technical, technological, organizational, commercial, economical, financial, tax-related and other resources with due account of the demand. Restructuring classification signs and types as well as restructuring aims specific for industrial enterprises are provided for.

Clinical outcomes with olanzapine long-acting injection: impact of the 3-hour observation period on patient satisfaction and well-being

Directory of Open Access Journals (Sweden)

Anand E

2016-10-01

Full Text Available Ernie Anand,1 Lovisa Berggren,2 John Landry,3 Ágoston Tóth,4 Holland C Detke5 1Neuroscience Medical Affairs, Eli Lilly & Company Ltd, Windlesham, UK; 2Global Statistical Sciences, Lilly Deutschland GmbH, Bad Homburg, Germany; 3Global Statistical Sciences, Eli Lilly Canada Inc., Toronto, ON, Canada; 4Neuroscience, Lilly Hungary, Budapest, Hungary; 5Psychiatry and Pain Disorders, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA Background: The objective of the present analysis is to determine the impact of the 3-hour observation period for olanzapine long-acting injection (LAI on patient satisfaction and well-being by comparing data collected before and after its implementation. Methods: This is a post hoc analysis of patients treated with olanzapine LAI in 1 a 6-month fixed-dose randomized controlled trial and/or 2 a 6-year open-label safety study. This analysis was limited to patients with schizophrenia who were treated with olanzapine LAI consistent with the approved indication and dosing recommendations of the European Union Summary of Product Characteristics (N=966. Of the 966 patients, the analysis further focused only on those patients who received both 1 at least one injection before the implementation of the 3-hour observation period and 2 at least one injection after implementation of the 3-hour observation period (N=487. Patient satisfaction was assessed with the three-item Patient Satisfaction with Medication Questionnaire-Modified. Responses were averaged across all postbaseline visits occurring before (ie, without the implementation of the 3-hour observation period and across all postbaseline visits occurring after (ie, with the implementation of the 3-hour observation period. In addition, the rate of postinjection delirium/sedation syndrome events was calculated. Results: There was no meaningful change after implementation of the 3-hour observation period in satisfaction (before: mean [SD] =4.0 [1.02] and

Alltägliche Lebensführung in der Kindergartenpraxis

DEFF Research Database (Denmark)

Chimirri, Niklas Alexander

dient dem Workshop als Grundlage, um mit Interessierten auch über deren Praxiserfahrungen mit Kindern (ob das nun „Forschung“ oder eine andere Praxis ist) zu diskutieren. Wer Lust hat, möge mir bis zum 1.9. 1-2 Seiten zum eigenen Projekt bzw. der eigenen Fragestellung per Mail zu schicken: VERSTECKTE...

Wuthering Heights

NARCIS (Netherlands)

Bronte, Emily

2005-01-01

Wuthering Heights tells the story of a romance between two youngsters: Catherine Earnshaw and an orphan boy, Heathcliff. After she rejects him for a boy from a better background he develops a lust for revenge that takes over his life. In attempting to win her back and destroy those he blames for his

Women's Political Representation & Participation in Decentralized ...

International Development Research Centre (IDRC) Digital Library (Canada)

x31

2008, inflicted women's rights since it accused women become sexual material and will be sanctioned because arousing lust and desire of men. • The ongoing debate to suspend the Draft Law on Health for about 14 years, particularly on the regulation of safe abortion. Yet, there are. 2.3 million unsafe abortion per year in.

PREDICTING VOLUNTARY INTAKE ON MEDIUM QUALITY ...

African Journals Online (AJOL)

found a good relationship between the rate constant for fermentation and ... By dividing voluntary feed intake into the ... voluntary feed intake will be equal to the rate at which the rumen is ... per abomosum to prevent any deficiency in protein restricting .... McDougall's saliva and was not included in the calculation of the lust ...

Does participation in a weight control program also improve clinical and functional outcomes for Chinese patients with schizophrenia treated with olanzapine?

Directory of Open Access Journals (Sweden)

Montgomery W

2014-07-01

Full Text Available William Montgomery,1 Tamas Treuer,2 Wenyu Ye,3 Hai Bo Xue,4 Sheng Hu Wu,4 Li Liu,4 Zbigniew Kadziola,5 Michael D Stensland,6 Haya Ascher-Svanum7 1Global Health Outcomes Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 2Neuroscience Research, Eli Lilly and Company, Budapest, Hungary; 3Global Statistical Sciences, Lilly Suzhou Pharmaceutical Company, Ltd, Shanghai, People's Republic of China; 4Medical Department, Lilly Suzhou Pharmaceutical Company, Ltd, Shanghai, People's Republic of China; 5Global Statistical Sciences, Eli Lilly GmbH, Vienna, Republic of Austria; 6Agile Outcomes Research, Inc., Rochester, MN, USA; 7Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN, USA Objectives: This study examined whether participation in a weight control program (WCP by patients with schizophrenia treated with olanzapine was also associated with improvements in clinical and functional outcomes. Methods: A post-hoc analysis was conducted using data from the Chinese subgroup (n=330 of a multi-country, 6-month, prospective, observational study of outpatients with schizophrenia who initiated or switched to oral olanzapine. At study entry and monthly visits, participants were assessed with the Clinical Global Impression of Severity, and measures of patient insight, social activities, and work impairment. The primary comparison was between the 153 patients who participated in a WCP at study entry (n=93 or during the study (n=60 and the 177 patients who did not participate in a weight control program (non-WCP. Mixed Models for Repeated Measures with baseline covariates were used to compare outcomes over time. Kaplan–Meier survival analysis was used to assess time to response. Results: Participants had a mean age of 29.0 years and 29.3 years, and 51.0% and 57.6% were female for WCP and non-WCP groups, respectively. Average initiated daily dose for olanzapine was 9.5±5.4 mg. WCP participants gained less weight than non-participants (3.9 kg vs

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Directory of Open Access Journals (Sweden)

Wacheck V

2011-05-01

Full Text Available Volker Wacheck1, Michael Lahn2, Gemma Dickinson3, Wolfgang Füreder4, Renata Meyer4, Susanne Herndlhofer4, Thorsten Füreder1, Georg Dorfner5, Sada Pillay2, Valérie André6, Timothy P Burkholder7, Jacqueline K Akunda8, Leann Flye-Blakemore9, Dirk Van Bockstaele9, Richard F Schlenk10, Wolfgang R Sperr4, Peter Valent4,111Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria; 2Early Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN, USA; 3Department of Pharmacokinetics, Eli Lilly and Company, Erl Wood Research Centre, Windlesham, Surrey, UK; 4Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria; 5Eli Lilly GesmbH, Medical Department, Vienna, Austria; 6Department of Statistics, Eli Lilly and Company, Erl Wood Research Centre, Surrey, UK; 7Discovery Chemistry Research and Technology, Eli Lilly and Company, Indianapolis, IN, USA; 8Nonclinical Toxicology, Eli Lilly and Company, Indianapolis, IN, USA; 9Flow Cytometry and Cell Analysis, Esoterix Clinical Trials Services, Mechelen, Belgium; 10Universitätsklinikum Ulm, Klinik für Innere Medizin III, Ulm, Germany; 11Ludwig Boltzmann Cluster Oncology, Vienna, AustriaBackground: Acute myeloid leukemia (AML is a life-threatening malignancy with limited treatment options in chemotherapy-refractory patients. A first-in-human dose study was designed to investigate a safe and biologically effective dose range for LY2457546, a novel multikinase inhibitor, in patients with relapsed AML.Methods: In this nonrandomized, open-label, dose escalation Phase I study, LY2457546 was administered orally once a day. Safety, pharmacokinetics, changes in phosphorylation of target kinases in AML blasts, and risk of drug–drug interactions (DDI were assessed.Results: Five patients were treated at the starting and predicted minimal biologically effective dose of 50 mg

Ravimikontsern võitis soodusravimitülis kohtus sotsiaalministeeriumi / Signe Kalberg

Index Scriptorium Estoniae

Kalberg, Signe, 1959-

2007-01-01

Tallinna halduskohtu otsusest rahvusvahelise farmaatsiakontserni Eli Lilly ja sotsiaalministeeriumi vahelises kohtuasjas aktiivsus- ja tähelepanuhäiretega lastele mõeldud ravimi soodustuse taotlumise kohta

The Conception of Virtue in the Philosophy of Islamic Ethics

Directory of Open Access Journals (Sweden)

Murat Demirkol

2014-07-01

Full Text Available The Ethics Theories which is based on the self have been developed by Muslim Philosophiers who based on the inherited ethics philisophy literature of Antic Period Greek Philosophiers. The most important feature that separates philosophical ethics perspective from teologic or mystical ethics perspectives is the self theory. At the same time this feature causes philosophical ethi cs to have universal character. Philosophical ethics theory aims at universal good and virtue. It is based on conditions and behaviors that have become skills and without change in a short time. Despite the effect of environmental factors, habits appear on a large scale based on people's temperament and they form moral behaviors' foundation. Habit is a general concept that express both virtue and non - virtue. because ideal of the ethics is virtue, we are going to talk about virtue in this communique. There a re three sources of habits in the self. Both lust power and wrath power are animal incitement powers. And the third one is mind that forms people's essence. The power of lust enables people to attract the things which they need while the power of wrath ena bles people to get rid of the things which they think think are harmful. Mind enables using of these powers in balance, therefore it is a manager and controller of them. The virtue of chastity arises from the balanced move of the lust power and the virtue of bravery originates from the balanced move of the power of wrath. The independent virtue of mind is wisdom. It is thought - ptovoking that the mind is responsible moderation and control of instigation powers. If the mind is balanced, it is a source of wisd om virtue. If the mind isn't balanced, it is a source of non - virtue. The virtue of justice appears when, based on the powers, the basic virtues which are formed from chastity, bravery and wisdom are in complete balance. In this case it is understood that j ustice a combination of virtues in one respect and

Developing an effective toxicology/quality assurance partnership. Improving quality, compliance, and cooperation.

Science.gov (United States)

Usher, R W

1995-12-01

Toxicology and Quality Assurance (QA) at Eli Lilly and Company are well integrated, yet still independent organizations that are aligned with the same overall business objective: to efficiently deliver a high-quality product to the customer. One of the keys to success has been the implementation of a monitoring/metric and trend analysis program of key work processes that are central to the delivery of final product. Our metrics program indicates that the multiple changes that we have made have resulted in a higher quality product. This paper will discuss the practical changes we have made as a part of our Total Quality journey. This article is based solely on the authors' experiences while at Eli Lilly and Company.

Associations between adherence and outcomes among older, type 2 diabetes patients: evidence from a Medicare Supplemental database

Directory of Open Access Journals (Sweden)

Boye KS

2016-08-01

Full Text Available Kristina Secnik Boye,1 Sarah E Curtis,1 Maureen J Lage,2 Luis-Emilio Garcia-Perez3 1Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 2HealthMetrics Outcomes Research, LLC, Bonita Springs, FL, 3Global Medical Affairs, Lilly Diabetes, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA Objective: To examine the association between adherence to glucose-lowering agents and patient outcomes, including costs, acute-care resource utilization, and complications, in an older, type 2 diabetic population.Data and methods: The study used Truven’s Medicare Supplemental database from July 1, 2009 to June 30, 2014. Patients aged 65 years or older were included if they had at least two type 2 diabetes diagnoses and received a glucose-lowering agent from July 1, 2010 through June 30, 2011. Multivariable analyses examined the relationships among 3-year patient outcomes and levels of adherence, proxied by the proportion of days covered. Outcomes included all-cause medical costs, diabetes-related medical costs, acute-care resource utilization, and acute complications.Results: In this study (N=123,235, higher adherence was linked to reduced costs and improved health outcomes. For example, comparing an individual with adherence of proportion of days covered <20% to one with proportion of days covered ≥80% illustrates an average saving of $28,824 in total 3-year costs. Furthermore, a 1% increase in adherence among 1,000 patients was associated with all-cause savings of $65,464 over 3 years. The probability of a hospitalization, an emergency room (ER visit, or an acute complication decreased monotonically as adherence levels got higher, as did the number of hospitalizations, ER visits, and days hospitalized (P<0.005.Conclusion: Higher adherence was associated with substantially less need for acute care, as indicated by a lowered probability of hospitalization or ER use, a reduced

Recent Naval Postgraduate School Publications.

Science.gov (United States)

1981-05-01

School,, (IPS-.531071O1)p 1W7. 3* Conhri Aceofthecna taraW 8to ncoen 0 mnkionai goostrophic adibxamat with. f1 itt 1 oh1 maduate School, (BPS-531h77041...Nor h Holand , 1977. 267 p. MorAn techniques of 3.A. - dynamic programming (Ch. 141) IN Naval operations analysis, 2nd ed. Naval lust. Press, 1977, p

Enter the iPad (or Not?)

Science.gov (United States)

Waters, John K.

2010-01-01

Few computing devices have sparked the burning gizmo lust ignited by the iPad. Apple's latest entry into the tablet PC market didn't generate much heat when it was first unveiled in January, but by April 3, the day of the official release, feverish customers were mobbing Apple stores. The company claims to have sold 300,000 iPads by midnight on…

An Analysis of the Relationships of Personnel Characteristics to the Performance of DD 963 Class Ships.

Science.gov (United States)

1983-12-01

Ready aterial Condition by ’% or sere. Mathematically it is defined by SPCC as: ndex- x ((w3) (Sun C-3) . (v4) (Sum C-4) ) (1 3) (Sun DIC-3)+(114) (Sum...tion was almost always a high school education, or lust less than that lvel of education. as a result, a new variable vas developed - 5SD# or

Ultimate Educational Aims, Overridingness, and Personal Well-Being

Science.gov (United States)

Haji, Ishtiyaque; Cuypers, Stefaan E.

2011-01-01

Discussion regarding education's aims, especially its ultimate aims, is a key topic in the philosophy of education. These aims or values play a pivotal role in regulating and structuring moral and other types of normative education. We outline two plausible strategies to identify and justify education's ultimate aims. The first associates these…

Reconstituted AIM2 inflammasome in cell-free system.

Science.gov (United States)

Kaneko, Naoe; Ito, Yuki; Iwasaki, Tomoyuki; Takeda, Hiroyuki; Sawasaki, Tatsuya; Migita, Kiyoshi; Agematsu, Kazunaga; Kawakami, Atsushi; Morikawa, Shinnosuke; Mokuda, Sho; Kurata, Mie; Masumoto, Junya

2015-11-01

Absent in melanoma 2 (AIM2) is an intracellular pattern-recognition receptor, which is a member of the PYHIN protein family, consisting of a PYD domain and an IFN-inducible nuclear localization (HIN) domain. AIM2 is reported to oligomerize with adaptor protein ASC upon sensing bacterial and viral cytosolic DNA in order to form the AIM2 inflammasome, which activates caspase-1 leading to IL-1β secretion. Dysregulation of AIM2 inflammasome is supposed to result in autoinflammatory and autoimmune diseases. Thus, the development of new targeted drugs against AIM2 inflammasome would be important for the treatment of these diseases. However, since AIM2 inflammasome is an intracellular receptor, enforced internalization of both ligands and candidate molecules is necessary for the screening of AIM2-inflammasome-targeted molecules. We developed a reconstituted AIM2 inflammasome in a cell-free system with amplified luminescent proximity homogeneous assay (Alpha). Strong Alpha signal was detected upon incubation with poly-deoxyadenylic-deoxythymidylic acid, poly(dA:dT), whereas no Alpha signal was detected upon incubation with muramyl dipeptide, one of the NLR ligands of Nod2 ligand. The interaction between AIM2 and ASC was disrupted by an anti-human ASC monoclonal antibody, CRID3, a class of diarylsulfonylurea-containing compounds, and glycyrrhizin, a substance found in liquorice root. Thus, the reconstituted AIM2 inflammasome in a cell-free system is useful for screening AIM2-inflammasome-targeted therapeutic molecules. Copyright © 2015 Elsevier B.V. All rights reserved.

Evaluation and cultural adaptation of a German version of the AIMS2-SF questionnaire (German AIMS2-SF).

NARCIS (Netherlands)

Rosemann, T.J.; Korner, T.; Wensing, M.J.P.; Schneider, A.; Szecsenyi, J.

2005-01-01

OBJECTIVES: The aim of the study was to examine the validity of a translated and culturally adapted version of the Arthritis Impact Measurement Scales 2, Short Form (AIMS2-SF) in patients suffering from osteoarthritis (OA) in primary care. METHODS: A structured procedure was used for the translation

Presidential Green Chemistry Challenge: 1999 Greener Synthetic Pathways Award

Science.gov (United States)

Presidential Green Chemistry Challenge 1999 award winner, Lilly Research Laboratories, developed a low-waste drug synthesis using yeast for a stereospecific reduction, reducing solvent amounts, and replacing chromium oxide.

Naised mõrvarite jälil / Kaisa Karu

Index Scriptorium Estoniae

Karu, Kaisa

2010-01-01

Kanal 2 ekraanil kaks naispeaosalistega krimisarja : uurija Lilly Rush (Kathryn Morris) sarjas "Jahtunud jälg" (USA, 2003-... ) ja Brenda Leigh Johnson (Kyra Sedgwick) seriaalis "Vahelevõtja" (USA, 2005-... )

Aim For a Healthy Weight

Science.gov (United States)

... out of your control, you can make positive lifestyle changes to lose weight and to maintain a healthy weight. These include a healthy eating plan and being more physically active. Take the Challenge When it comes to aiming for a healthy ...

Discrimination and the aim of proportional representation

DEFF Research Database (Denmark)

Lippert-Rasmussen, Kasper

2008-01-01

Many organizations, companies, and so on are committed to certain representational aims as regards the composition of their workforce. One motivation for such aims is the assumption that numerical underrepresentation of groups manifests discrimination against them. In this article, I articulate...... representational aims in a way that best captures this rationale. My main claim is that the achievement of such representational aims is reducible to the elimination of the effects of wrongful discrimination on individuals and that this very important concern is, in principle, compatible with the representation...... of discrimination against numerically overrepresented groups, or overlook the innocently different ambitions of some numerically underrepresented groups. In relation to the latter point, I appeal to the fact that many luck egalitarians think justice should be ambition sensitive (but endowment insensitive). Also...

Aims, assessments and workplace needs

Science.gov (United States)

Black, Paul

1997-03-01

This paper attempts to consider the aims that undergraduate physics degree courses actually reflect and serve in the light of the employment patterns of graduates and of the expressed needs of employers. Calling on evidence mainly from the UK, it reviews analyses of what degree examinations actually test, and goes on to quote criticisms of their courses and radical proposals to change them adopted by the senior physics professors in the UK. The discussion is then broadened by discussion of evidence, about the employment of graduates and about the priorities that some industrialists now give in the qualities that they look for when recruiting new graduates. The evidence leads to a view that radical changes are needed, both in courses and examinations, and that there is a need for university departments to work more closely with employers in re-formulating the aims and priorities in their teaching.

Discrimination and the aim of proportional representation

DEFF Research Database (Denmark)

Lippert-Rasmussen, Kasper

2008-01-01

Many organizations, companies, and so on are committed to certain representational aims as regards the composition of their workforce. One motivation for such aims is the assumption that numerical underrepresentation of groups manifests discrimination against them. In this article, I articulate r...

Method detection limit determination and application of a convenient headspace analysis method for methyl tert-butyl ether in water.

Science.gov (United States)

O'Neill, Dennis T; Rochette, Elizabeth A; Ramsey, Philip J

2002-11-15

Methyl tert-butyl ether (MTBE) is a common groundwater contaminant, introduced to the environment by leaking petroleum storage tanks, urban runoff, and motorized watercraft. In this study. a simplified (static) headspace analysis method was adapted for determination of MTBE in water samples and soil water extracts. The MDL of the headspace method was calculated to be 2.0 microg L(-1) by the EPA single-concentration design method(1) and 1.2 microg L(-1) by a calibration method developed by Hubaux and Vos (Hubaux, A.; Vos, G. Anal. Chem. 1970,42, 849-855). The MDL calculated with the Hubaux and Vos method was favored because it considers both a true positive and a false positive. The static headspace method was applied to analysis of a tap water sample and a monitoring well sample from a gasoline service station, a river sample, and aqueous extracts from soil excavated during removal of a leaking underground storage tank (LUST). The water samples examined in this study had MTTBE concentrations ranging from 6 to 19 microg L(-1). Aqueous extracts of a soil sample taken from the LUST site had 8 microg L(-1) MTBE.

Täiskasvanud õppija nädal 2010 / Reet Saar

Index Scriptorium Estoniae

Saar, Reet, 1959-

2010-01-01

Raplamaa Aasta õppija on Märjamaa perearstikeskuse õde Ljudmilla Tamp, Aasta koolitaja tantsuõpetaja Lilli Teesalu, Aasta koolitussõbralikum organisatsioon on Kehtna põhikool ja aasta koolitussõbralikum omavalitsus Kohila vald

Take AIM and Keep Your Students Engaged

Science.gov (United States)

Nash, Catherine

2014-01-01

This paper outlines the benefits to distance education teachers of formatting a weekly online newsletter in accordance with motivational learning theory. It reflects on the delivery of weekly AIM newsletters to undergraduate economics students at the Open Polytechnic of New Zealand via Moodle. The acronym, AIM, stands for Academic content,…

Praegust mälubuumi iseloomustab utoopiliste tulevikuvisioonide puudumine : intervjuu Jeffrey Olickuga / Jeffrey Olick ; küsitles Siobhan Kattago, inglise k. tõlkinud Piret Peiker

Index Scriptorium Estoniae

Olick, Jeffrey

2007-01-01

Virginia Ülikooli sotsioloogia- ja ajalooprofessor Jeffrey K. Olick on kollektiivse mälu uurimise vallas kujunemas üheks tänapäeva kõige tuntumaks ja viljakamaks autoriks. Jeffrey Olick osales ettekandega Tallinna Ülikooli teadussümpoosionil "Kellele kuulub mälu?" ja TLÜ suvekoolis "Kuidas kollektiivid mäletavad?" Temaga vestles kollektiivsest mälust sotsioloogiadoktor ja TLÜ Eesti Humanitaarinstituudi dotsent Siobhan Kattago

Märkmeid surnud majast : tänase Euroopa mälu / Tony Judt ; tõlk. Märt Väljataga

Index Scriptorium Estoniae

Judt, Tony, 1948-2010

2006-01-01

Erinevustest holokausti mäletamises Lääne- ja Ida-Euroopas. Miks erinevad venelaste ja Venemaa satelliitriikide mälestused Teisest maailmasõjast. Venelaste lõhenenud mälust - kodanikuühendustest "Memoriaal" ja "Pamjat". Kiusatusest ületada kommunismimälestus selle peapeale pööramisega. Ebamugavast tõest, et enamiku inimeste jaoks ei olnud 1939. ja 1945. a. vahel juutidega toimunu tegelikult tähtis.

Implementation of an Anesthesia Information Management System (AIMS).

Science.gov (United States)

Douglas, James R; Ritter, Melody J

2011-01-01

During the administration of anesthesia, the anesthesia provider has historically created a paper record, charted manually, that included extensive patient care-related data (vital signs, other parameters, etc) and commentaries. DocuSys, a proprietary anesthesia information management system (AIMS), creates an electronic version of the anesthesia record and provides additional information. It electronically captures data from clinical monitors and other sources, including scheduling applications and laboratory computers. The AIMS facilitates chart entries such as drug doses and case narratives. Benefits of an AIMS include improved legibility of the anesthesia record and greater efficiency in documentation efforts. Use of the AIMS assists the practitioner with decision support logic, such as the timing of antibiotic administration and the inclusion of legally required documentation. Upon case completion, the AIMS data are immediately available to other information systems, such as billing and medical records. Data can be made available from a single case or, more important, from thousands of cases to analyze variables such as efficiency of services, adherence to best practices, patient outcomes, and clinical research. The AIMS was deployed at the main campus of the Ochsner Health System on March 26, 2009. In this article, we discuss the issues involved in the AIMS implementation process: the successes, surprises, and continued challenges.

AIMES Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Jha, Shantenu [Rutgers Univ., New Brunswick, NJ (United States)

2017-01-31

Many important advances in science and engineering are due to large-scale distributed computing. Notwithstanding this reliance, we are still learning how to design and deploy large-scale production Distributed Computing Infrastructures (DCI). The AIMES project was conceived against this backdrop, following on the heels of a comprehensive survey of scienti c distributed applications [1]. The survey established, arguably for the rst time, the relationship between infrastructure and scienti c distributed applications. It examined well known contributors to the complexity associated with infrastructure, such as inconsistent internal and external interfaces, and demonstrated the correlation with application brittleness. It discussed how infrastructure complexity reinforces the challenges inherent in developing distributed applications.

Youthful Lust and Violation of Mobile Phone Rule in a Private Christian Mission University, South West Nigeria

Science.gov (United States)

Ojo, Omonijo Dare; Ugochukwu, Nnedum Obiajulu Anthony; Obinna, Ezeokana Jude

2011-01-01

This study aims at discovering the difference in the perceived lack of privacy in communication and violation of mobile phone rule among students in a Private Christian Mission University, South-West Nigeria. It equally tries to discover if there is a difference in the perceived students' desire to express love to the opposite sex and violation of…

Examining the Effect of Medication Adherence on Risk of Subsequent Fracture Among Women with a Fragility Fracture in the U.S. Medicare Population.

Science.gov (United States)

Keshishian, Allison; Boytsov, Natalie; Burge, Russel; Krohn, Kelly; Lombard, Louise; Zhang, Xiang; Xie, Lin; Baser, Onur

2017-11-01

In the United States, osteoporosis affects approximately 10 million people, of whom 80% are women, and it contributes a significant clinical burden to the community. Poor adherence to osteoporosis medications adds to the overall burden of illness. To examine the association of osteoporosis medication adherence and the risk of a subsequent fracture among Medicare-enrolled women with a previous fragility fracture. This study was a retrospective observational analysis of U.S. administrative claims data among female Medicare beneficiaries who had a nontrauma closed fragility fracture between January 1, 2011, and December 31, 2011. Patients were required to have continuous medical and pharmacy enrollment 12 months pre- and postfracture date. In addition, patients were required to have an osteoporosis medication prescription for a bisphosphonate (alendronate, risedronate, pamidronate, etidronate, zoledronate, and tiludronate), calcitonin, denosumab, raloxifene, or teriparatide during the follow-up period. Adherence was calculated using cumulative medication possession ratio (MPR) from the treatment initiation date in 30-day increments. MPR was stratified into high adherence (MPR ≥ 80%), moderate adherence (50% ≤ MPR > 80%), and low adherence (MPR 80%; n = 4,602, 16.6%). After adjusting for demographics and clinical characteristics, patients with low and moderate adherence to osteoporosis medications were 33% (hazard ratio [HR] = 1.33; 95% CI = 1.17-1.50, P Eli Lilly. Xie, Keshishian, and Baser are employees of STATinMED Research, a paid consultant to Eli Lilly in connection with the study design, data analysis, and development of the manuscript for this study. Boytsov, Burge, Lombard, and Zhang are employees and stock owners of Eli Lilly. At the time of research, Krohn was an employee of Eli Lilly. Study concept and design were contributed by Burge and Lombard, along with the other authors. Xie, Baser, and Keshishian took the lead in data collection, assisted by the

Predictors of antipsychotic monotherapy with olanzapine during a 1-year naturalistic study of schizophrenia patients in Japan

Directory of Open Access Journals (Sweden)

Ye W

2012-01-01

Full Text Available Wenyu Ye1, Haya Ascher-Svanum2, Jennifer A Flynn3, Yuka Tanji3, Michihiro Takahashi3,41Lilly Suzhou Pharmaceutical Co, Shanghai, People's Republic of China; 2Eli Lilly and Company, Indianapolis, IN, USA; 3Lilly Research Laboratories Japan, Eli Lilly Japan K.K., Kobe, 4Terauchi-Takahashi Psychiatric Clinic, Ashiya, JapanPurpose: Although expert guidelines for the treatment of schizophrenia recommend antipsychotic monotherapy, the use of antipsychotic polypharmacy is common. This study identified characteristics that differentiate patients with schizophrenia who are treated with olanzapine monotherapy versus polypharmacy in usual care in Japan.Patients and methods: In a large (N = 1850 prospective, observational study, Japanese patients with schizophrenia who initiated treatment with olanzapine were followed for 1 year. Consistent with past research, antipsychotic polypharmacy was defined as the concurrent use of olanzapine and another antipsychotic for at least 60 days. Switching was defined as discontinuing a prior antipsychotic therapy rather than augmenting the medication regimen. Predictors of antipsychotic monotherapy were based on information available at the time of olanzapine initiation. Baseline characteristics were compared using t-tests and Χ2 tests. Stepwise logistic regression was used to identify independent predictors of monotherapy.Results: Patients treated with olanzapine monotherapy (43.2% differed from those treated with antipsychotic polypharmacy (56.8% on demographics, treatment history, baseline symptom levels, functional levels, and treatment-emergent adverse events. Stepwise logistic regression identified multiple variables that significantly predicted monotherapy: older age, shorter duration of schizophrenia, outpatient status, comorbid medical conditions, lower body mass index, no prior anticholinergic use, no prior mood stabilizer use, and switching from a previous antipsychotic (typical or atypical

Predictors of continuation with olanzapine during the 1-year naturalistic treatment of patients with schizophrenia in Japan

Directory of Open Access Journals (Sweden)

Ye W

2011-12-01

Full Text Available Wenyu Ye1, Haya Ascher-Svanum2, Yuka Tanji3, Jennifer A Flynn3, Michihiro Takahashi3,41Lilly Suzhou Pharmaceutical Co, Shanghai, People’s Republic of China; 2Eli Lilly and Company, Indianapolis, IN, USA; 3Lilly Research Laboratories Japan, Eli Lilly Japan KK, Kobe, 4Terauchi-Takahashi Psychiatric Clinic, Ashiya, JapanPurpose: Treatment continuation is considered an important measure of antipsychotic effectiveness in schizophrenia, reflecting the medication’s efficacy, safety, and tolerability from both patients’ and clinicians’ perspectives. This study identified characteristics of patients with schizophrenia who continue olanzapine therapy for a 1-year period in Japan.Methods: In a large (N = 1850, prospective, observational study, Japanese patients with schizophrenia who initiated treatment with olanzapine were followed for 1 year. Baseline characteristics were compared using t-tests and chi-square tests. Stepwise logistic regression was used to identify independent baseline predictors of treatment continuation.Results: Most patients (68.2% continued with olanzapine therapy for the full 1-year study period, with an average duration of 265.5 ± 119.4 days. At baseline, patients who continued were significantly more likely to be male, older, and inpatients; have longer illness duration, higher negative and cognitive symptoms, better health-related quality of life, and prior anticholinergic use. Continuers were significantly less likely to engage in social activities, live independently, work for pay, or have prior antidepressant use. Continuers showed significantly greater early (3-month improvement in global symptom severity. Logistic regression found that continuation was significantly predicted by longer illness duration, lower positive symptoms, higher negative symptoms, and better health-related quality of life.Conclusions: In this large naturalistic study in Japan, most patients with schizophrenia stayed on olanzapine therapy for

Aims and harvest of moral case deliberation.

Science.gov (United States)

Weidema, Froukje C; Molewijk, Bert A C; Kamsteeg, Frans; Widdershoven, Guy A M

2013-09-01

Deliberative ways of dealing with ethical issues in health care are expanding. Moral case deliberation is an example, providing group-wise, structured reflection on dilemmas from practice. Although moral case deliberation is well described in literature, aims and results of moral case deliberation sessions are unknown. This research shows (a) why managers introduce moral case deliberation and (b) what moral case deliberation participants experience as moral case deliberation results. A responsive evaluation was conducted, explicating moral case deliberation experiences by analysing aims (N = 78) and harvest (N = 255). A naturalistic data collection included interviews with managers and evaluation questionnaires of moral case deliberation participants (nurses). From the analysis, moral case deliberation appeals for cooperation, team bonding, critical attitude towards routines and nurses' empowerment. Differences are that managers aim to foster identity of the nursing profession, whereas nurses emphasize learning processes and understanding perspectives. We conclude that moral case deliberation influences team cooperation that cannot be controlled with traditional management tools, but requires time and dialogue. Exchanging aims and harvest between manager and team could result in co-creating (moral) practice in which improvements for daily cooperation result from bringing together perspectives of managers and team members.

Leaking Underground Tanks in Rhode Island; LUSTs12

Data.gov (United States)

University of Rhode Island Geospatial Extension Program — This dataset shows the location of storage tanks and associated piping used for petroleum and certain hazardous substances that have experienced leaks as determined...

Ketamine: stimulating antidepressant treatment?

Science.gov (United States)

Malhi, Gin S; Byrow, Yulisha; Cassidy, Frederick; Cipriani, Andrea; Demyttenaere, Koen; Frye, Mark A; Gitlin, Michael; Kennedy, Sidney H; Ketter, Terence A; Lam, Raymond W; McShane, Rupert; Mitchell, Alex J; Ostacher, Michael J; Rizvi, Sakina J; Thase, Michael E; Tohen, Mauricio

2016-05-01

The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations. G.S.M. Grant/research support: National Health Medical Research Council, NSW Health, Ramsay Health, American Foundation for Suicide Prevention, AstraZeneca, Eli Lilly & Co, Organon, Pfizer, Servier, and Wyeth; has been a speaker for Abbott, AstraZeneca, Eli Lilly & Co, Janssen Cilag, Lundbeck, Pfizer, Ranbaxy, Servier, and Wyeth; consultant: AstraZeneca, Eli Lilly & Co, Janssen Cilag, Lundbeck, and Servier. M.A.F. Grant support: AssureRx, Janssen Research & Development, Mayo Foundation, Myriad, National Institute of Alcohol Abuse and Alcoholism (NIAAA), National Institute of Mental Health (NIMH), Pfizer. Consultant (Mayo): Janssen Research & Development, LLC, Mitsubishi Tanabe Pharma Corporation, Myriad Genetics, Neuralstem Inc., Sunovion, Supernus Pharmaceuticals, Teva Pharmaceuticals. CME/travel support: American Physician Institute, CME Outfitters. Financial interest/Mayo Clinic 2016: AssureRx. S.H.K. Grant/research support: Brain Canada, Bristol Meyer Squibb, CIHR, Janssen, Johnson & Johnson, Lundbeck, Ontario Brain Institute, Pfizer, Servier, St. Jude Medical, Sunovion. T.A.K. Grant/research support (through Stanford University): Sunovion Pharmaceuticals and Merck & Co., Inc.; consultant/advisory board bember: Allergan, Inc., Janssen Pharmaceuticals, Myriad Genetic Laboratories, Inc., and Sunovion Pharmaceuticals; lecture honoraria (not Speaker's Bureau payments): Glaxo

Korp! Filiae Patriae 85. aastapäeva pidustused Los Angeleses / Lumme Erilt

Index Scriptorium Estoniae

Erilt, Lumme

2005-01-01

5. novembril 2005 tähistas Filiae Patriae Kalifornia koondis Los Angelese Eesti Majas piduliku õestuspeo ning ühise perekonnaõhtuga koos korp! Rotaliaga aastapäeva. Peeti kõnesid, oli tervitusi, muusikat, palju lilli

AIM: An Integrated Approach to Organizational Improvement

Directory of Open Access Journals (Sweden)

Ronald A. Styron, Jr.

2016-02-01

Full Text Available This concept paper is based on the new problem-solving model of Blended Leadership called Alloy Improvement Model (AIM. This model consists of an integration of change theory, leadership theory, and democratic principles and practices to form a comprehensive problem-solving strategy for organizational leaders. The utilization of AIM will assist leaders in moving from problems to solutions while engaging stakeholders in a comprehensive, efficient, inclusive, informative, integrated and transparent process.

[Content analysis of food adverts aimed at children].

Science.gov (United States)

Ponce-Blandón, José Antonio; Pabón-Carrasco, Manuel; Lomas-Campos, María de Las Mercedes

To determine the contents and persuasive techniques used in processed food adverts aimed at children in Andalusia, comparing them with those aimed at adults. Study based on advert content analysis with two phases: a descriptive design phase and an analytical observational design phase. A sample of adverts from 60hours of broadcasting from the two most watched television channels in Andalusia. A total of 416 food and non-alcoholic beverage adverts were obtained, for 91 different products. Approximately 42.9% (n=39) was aimed at children and 53.8% (n=49) were products classified as "unhealthy". Unhealthy foods were more common in adverts for children (p <0.001). Significant differences were found between the ads aimed at adults and those aimed at children. Emotional and irrational persuasive resources such as fantasy (p <0.001), cartoons (p <0.001) or offering gifts with the purchase of the product (p=0.003) were observed more frequently in adverts for children. Food advertising aimed at children in Andalusia is mainly based on offering products with a low nutritional value and using persuasive resources based on fantasy or gifts. The message is focused on the incentive and not the food. More effective measures than the current self-regulatory systems must be put in place to counter these distorted adverts. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

Is Fitts' law continuous in discrete aiming?

Directory of Open Access Journals (Sweden)

Rita Sleimen-Malkoun

Full Text Available The lawful continuous linear relation between movement time and task difficulty (i.e., index of difficulty; ID in a goal-directed rapid aiming task (Fitts' law has been recently challenged in reciprocal performance. Specifically, a discontinuity was observed at critical ID and was attributed to a transition between two distinct dynamic regimes that occurs with increasing difficulty. In the present paper, we show that such a discontinuity is also present in discrete aiming when ID is manipulated via target width (experiment 1 but not via target distance (experiment 2. Fitts' law's discontinuity appears, therefore, to be a suitable indicator of the underlying functional adaptations of the neuro-muscular-skeletal system to task properties/requirements, independently of reciprocal or discrete nature of the task. These findings open new perspectives to the study of dynamic regimes involved in discrete aiming and sensori-motor mechanisms underlying the speed-accuracy trade-off.

Tutorial: Asteroseismic Stellar Modelling with AIMS

Science.gov (United States)

Lund, Mikkel N.; Reese, Daniel R.

The goal of aims (Asteroseismic Inference on a Massive Scale) is to estimate stellar parameters and credible intervals/error bars in a Bayesian manner from a set of asteroseismic frequency data and so-called classical constraints. To achieve reliable parameter estimates and computational efficiency, it searches through a grid of pre-computed models using an MCMC algorithm—interpolation within the grid of models is performed by first tessellating the grid using a Delaunay triangulation and then doing a linear barycentric interpolation on matching simplexes. Inputs for the modelling consist of individual frequencies from peak-bagging, which can be complemented with classical spectroscopic constraints. aims is mostly written in Python with a modular structure to facilitate contributions from the community. Only a few computationally intensive parts have been rewritten in Fortran in order to speed up calculations.

Effect of monensin on fermentation characteristics of the artificial rumen.

OpenAIRE

Wallace, R J; Cheng, K J; Czerkawski, J W

1980-01-01

Addition of monensin (Rumensin, Eli Lilly and Co.) to an artificial rumen immediately depressed the digestion of roughage and of roughage/concentrate (50:50) feeds. Methane and propionate production were affected only with the roughage/concentrate feed.

Pursuing the Triple Aim: The First 7 Years.

Science.gov (United States)

Whittington, John W; Nolan, Kevin; Lewis, Ninon; Torres, Trissa

2015-06-01

POLICY POINTS: In 2008, researchers at the Institute for Healthcare Improvement (IHI) proposed the Triple Aim, strategic organizing principles for health care organizations and geographic communities that seek, simultaneously, to improve the individual experience of care and the health of populations and to reduce the per capita costs of care for populations. In 2010, the Triple Aim became part of the US national strategy for tackling health care issues, especially in the implementation of the Patient Protection and Affordable Care Act (ACA) of 2010. Since that time, IHI and others have worked together to determine how the implementation of the Triple Aim has progressed. Drawing on our 7 years of experience, we describe 3 major principles that guided the organizations and communities working on this endeavor: creating the right foundation for population management, managing services at scale for the population, and establishing a learning system to drive and sustain the work over time. In 2008, researchers at the Institute for Healthcare Improvement (IHI) described the Triple Aim as simultaneously "improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care for populations." IHI and its close colleagues had determined that both individual and societal changes were needed. In 2007, IHI began recruiting organizations from around the world to participate in a collaborative to implement what became known as the Triple Aim. The 141 participating organizations included health care systems, hospitals, health care insurance companies, and others closely tied to health care. In addition, key groups outside the health care system were represented, such as public health agencies, social services groups, and community coalitions. This collaborative provided a structure for observational research. By noting the contrasts between the contexts and structures of those sites in the collaborative that progressed and

High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs.

Science.gov (United States)

Lieblich, Samuel M; Castle, David J; Pantelis, Christos; Hopwood, Malcolm; Young, Allan Hunter; Everall, Ian P

2015-10-01

Major depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations. D.J.C. has received grants and personal fees from Eli Lilly, Janssen-Cilag, Roche, Allergen, Bristol-Myers Squibb, Pfizer, Lundbeck, AstraZeneca, Hospira, Organon, Sanofi-Aventis, and Wyeth during the writing of this review. C.P. has received grant support from Janssen-Cilag, Eli Lilly, Hospira (Mayne), AstraZeneca, and received honoraria for consultancy to Janssen-Cilag, Eli Lilly, Hospira (Mayne), AstraZeneca, Pfizer, Schering Plough, and Lundbeck. Over the past 2 years he has participated on advisory boards for Janssen-Cilag and Lundbeck, and received honoraria for talks presented at educational meetings organised by AstraZeneca, Janssen-Cilag and Lundbeck. M.H. has received personal fees or grants from Lundbeck, AstraZeneca and Servier during the writing of this review. A.H.Y. reports personal fees from Lundbeck, Sunovion, AstraZeneca and Janssen outside the submitted work. I.P.E. has received personal fees or grants from Lundbeck, AstraZeneca, and Abbvie during the writing of this review. © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.

Instructing high school students in forensic environmental science using Brownfield Action

Science.gov (United States)

Bower, Peter; Liddicoat, Joseph; Patterson, Angelica; Kelsey, Ryan; Cox, Alice; Tynes, Nicholas

2010-05-01

Barnard College and Columbia University's Center for New Media Teaching and Learning's Brownfield Action is a digital web-based, interactive simulation that combines lecture, laboratory exercises, and individual and collaborative out-of-classroom assignments. The objective of the instruction is to locate and define a subsurface plume of gasoline whose point source is a leaking underground storage tank (LUST) at a gas station. In the fall of 2009, fifteen pre-college high school students from the five boroughs of New York City used Brownfield Action in a 12-week after-school enrichment program at Barnard to investigate the gasoline plume using a variety of geophysical methods - excavation, ground penetrating radar, magnetic metal detection, soil gas, and drilling. The investigation resulted in individual Phase One Site Assessment Reports about the LUST. As coordinators and instructors of the program, we will share our experience teaching the students and the advantages and challenges of using a digital simulation as an instructional centerpiece. Such instruction is intended to include civic engagement and responsibility as part of science education and to create a curriculum that, instead of relying on fragmented and abstract instruction, provides students with a realistic, inquiry-based, and interdisciplinary construction of knowledge.

Sügisene moevaatemäng / Britt Rosen

Index Scriptorium Estoniae

Rosen, Britt, 1968-

2008-01-01

FIBITi moepäevad Viru keskuses, korraldaja Anu Kikas. Arne Niidu, Anu Samarüütel-Longi, Tanel Veenre kollektsioonidest. Kalle Aasamäe, Lilli Jahilo, Aet Alevi, Anu Samarüütel-Longi ja Tanel Veenre kommentaarid

Mõtteid raamatust / Koost. Heigi Aaviste

Index Scriptorium Estoniae

1995-01-01

Aut.: Maire Liivamets, Paul Luhtein, Paul-Eerik Rummo, Maksim Gorki, Johannes Semper, R.Descartes, Valmar Adams, Lilli Promet, Paul Rummo, Cicero, Honoré de Balzac, Aleksandr Pushkin, Epikuros, Debora Vaarandi, Arvi Siig, Helene Johani, Juhan Smuul, Friedebert Tuglas

Aiming for the ordinary

DEFF Research Database (Denmark)

Offersen, Sara Marie Hebsgaard

that the Danes are encouraged to be alert to still earlier and vaguer bodily signs of potential cancer and seek care ‘in time’. With biomedical constructions such as ‘cancer awareness’ and ‘alarm symptoms of cancer’ and the retrospectively oriented definition of life before symptoms-based healthcare seeking...... and articulation of bodily sensations, and how decisions about healthcare seeking are established in this context. This dissertation aims to explore these matters from the perspective of the Danish middle class, mainly focusing on how sensations are ascribed meaning as symptoms and how they are evoked...... on a continuum between what is locally considered ordinary and extraordinary. Overall, the dissertation argues that inquiries into morality and potentiality provide valuable insights into healthcare seeking practices and the making and management of symptoms in everyday life. The dissertation is based on 18...

The Agreement between Auscultation and Lung Ultrasound in Hemodialysis Patients: The LUST Study.

Science.gov (United States)

Torino, Claudia; Gargani, Luna; Sicari, Rosa; Letachowicz, Krzysztof; Ekart, Robert; Fliser, Danilo; Covic, Adrian; Siamopoulos, Kostas; Stavroulopoulos, Aristeidis; Massy, Ziad A; Fiaccadori, Enrico; Caiazza, Alberto; Bachelet, Thomas; Slotki, Itzchak; Martinez-Castelao, Alberto; Coudert-Krier, Marie-Jeanne; Rossignol, Patrick; Gueler, Faikah; Hannedouche, Thierry; Panichi, Vincenzo; Wiecek, Andrzej; Pontoriero, Giuseppe; Sarafidis, Pantelis; Klinger, Marian; Hojs, Radovan; Seiler-Mussler, Sarah; Lizzi, Fabio; Siriopol, Dimitrie; Balafa, Olga; Shavit, Linda; Tripepi, Rocco; Mallamaci, Francesca; Tripepi, Giovanni; Picano, Eugenio; London, Gérard Michel; Zoccali, Carmine

2016-11-07

Accumulation of fluid in the lung is the most concerning sequela of volume expansion in patients with ESRD. Lung auscultation is recommended to detect and monitor pulmonary congestion, but its reliability in ESRD is unknown. In a subproject of the ongoing Lung Water by Ultra-Sound Guided Treatment to Prevent Death and Cardiovascular Complications in High Risk ESRD Patients with Cardiomyopathy Trial, we compared a lung ultrasound-guided ultrafiltration prescription policy versus standard care in high-risk patients on hemodialysis. The reliability of peripheral edema was tested as well. This study was on the basis of 1106 pre- and postdialysis lung ultrasound studies (in 79 patients) simultaneous with standardized lung auscultation (crackles at the lung bases) and quantification of peripheral edema. Lung congestion by crackles, edema, or a combination thereof poorly reflected the severity of congestion as detected by ultrasound B lines in various analyses, including standard regression analysis weighting for repeated measures in individual patients (shared variance of 12% and 4% for crackles and edema, respectively) and κ-statistics (κ ranging from 0.00 to 0.16). In general, auscultation had very low discriminatory power for the diagnosis of mild (area under the receiver operating curve =0.61), moderate (area under the receiver operating curve =0.65), and severe (area under the receiver operating curve =0.68) lung congestion, and the same was true for peripheral edema (receiver operating curve =0.56 or lower) and the combination of the two physical signs. Lung crackles, either alone or combined with peripheral edema, very poorly reflect interstitial lung edema in patients with ESRD. These findings reinforce the rationale underlying the Lung Water by Ultra-Sound Guided Treatment to Prevent Death and Cardiovascular Complications in High Risk ESRD Patients with Cardiomyopathy Trial, a trial adopting ultrasound B lines as an instrument to guide interventions aimed at

Piiriäärne lava valmistub taas esietenduseks / Margus Haav

Index Scriptorium Estoniae

Haav, Margus, 1969-

2008-01-01

Lõuna-Eestis Lilli külas algaval Nava lava festivalil tuuakse publiku ette Nava talu peremehe Jaak Kõdari näidend "Jukra", lavastaja Silvia Soro. Üht kandvat rolli mängib näitleja Lembit Eelmäe

CARATTERI GEOCHIMICI DEL MANTELLO SORGENTE DEL MAGMATISMO NAPOLETANO: NUOVE CONOSCENZE DALLO STUDIO DELLE OFIOLITI DEL SETTORE LUCANO DELL’APPENNINO MERIDIONALE

OpenAIRE

Mazzeo, Fabio Carmine

2014-01-01

Introduction The Mediterranean area is one of the most complex geodynamic settings of the world (e.g., Carminati et al., 2012, and references therein) as clearly illustrated by the huge variety of igneous lithologies. On the basis of trace element concentrations, and isotopic compositions, the latter being extremely variable from typical mantle to typical crustal values, sectors characterized by either anorogenic (Lustrino and Wilson, 2007) or orogenic magmatism (Harangi et al., 2006; Lust...

Moeloojad võtavad modelliks unarusse jäetud inimesi / Anneli Aasmäe

Index Scriptorium Estoniae

Aasmäe, Anneli, 1973-

2011-01-01

Eesti Kunstiakadeemia ja Turu Novia ülikooli ühisprojektist "Fashion Empowerment", mille raames kavatsevad tudengid pühenduda mingile spetsiifilise vajadusega inimgrupile sobivate riiete ja jalatsite tegemisele. Projekti juhib moedisainer Lilli Jahilo. Ratastoolikasutajatele hakkab jalatseid disainima nahakunsti eriala tudeng Mari Maripuu

Suicidality and aggression during antidepressant treatment

DEFF Research Database (Denmark)

Sharma, Tarang; Guski, Louise Schow; Freund, Nanna

2016-01-01

reports for duloxetine, fluoxetine, paroxetine, sertraline, and venlafaxine obtained from the European and UK drug regulators, and summary trial reports for duloxetine and fluoxetine from Eli Lilly's website.Eligibility criteria for study selection Double blind placebo controlled trials that contained any...

Hydrocarbon source rock potential evaluation of the Late Paleocene ...

Indian Academy of Sciences (India)

63

research is available on its source rock potential evaluation at Nammal Gorge Section in the Salt. Range, Potwar Basin .... methods of Tucker (2003) and Assaad (2008) have been followed. A total of fifteen ..... Business Media. Baker D M, Lillie ...

Erektsioonihäire põhjustest / Anne Veskimeister

Index Scriptorium Estoniae

Veskimeister, Anne, 1960-

2004-01-01

Androloog Margus Punab, kardioloog Arvo Rosenthal ja psühholoog Imre Rammul tõid möödunud nädalal toimunud ravimifirma Ely Lilly loengupäeval esile erektsioonihäirete põhjused, seosed teiste haigustega ja ravivõimalused

Grjaznoje proshloje kuklõ Barbi / Igor Silenko

Index Scriptorium Estoniae

Silenko, Igor

2002-01-01

Nukk Barbie saamislugu - meestele mõeldud seksapiilne saksa nukuke Lilly (autoriks disainer Max Weissbrodt) sai ameerika disaineri Ruth Handleri käe all uue näo ja nime ning debüteeris 1959. a. New Yorgi mänguasjade laadal

Effectiveness and safety of oral olanzapine treatment transitioned from rapid-acting intramuscular olanzapine for agitation associated with schizophrenia

Directory of Open Access Journals (Sweden)

Katagiri H

2018-04-01

Full Text Available Hideaki Katagiri,1 Masanori Taketsuna,2 Shinpei Kondo,3 Kenta Kajimoto,4 Etsuko Aoi,5 Yuka Tanji1 1Bio-Medicines, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2Statistical Sciences, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 3Post Marketing Study Management, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 4Scientific Communications, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 5Global Patient Safety Japan, Quality and Patient Safety, Eli Lilly Japan K.K., Kobe, Japan Objective: To assess the effectiveness and safety of oral olanzapine treatment transitioned from rapid-acting intramuscular olanzapine (RAIM in patients with acute agitation associated with schizophrenia in a real-world clinical setting. Methods: The postmarketing surveillance study with a 3-day observational period after the last RAIM administration was conducted (original study. Following this, an extended study was added for patients who received oral olanzapine after RAIM administration during the original study period, in order to additionally observe them for 7 days after initial RAIM administration. Effectiveness and safety from initial RAIM administration were evaluated using the Positive and Negative Syndrome Scale-Excited Component score and treatment-emergent adverse events (TEAEs, respectively. Results: The effectiveness and safety analysis set included a total of 521 and 522 patients, respectively. A majority of patients received 10 mg of RAIM (475/522 patients, 91.0%. The mean ± SD total Positive and Negative Syndrome Scale-Excited Component score was 23.6±6.2 (n=318 at baseline (before initial RAIM administration, 17.4±6.8 (n=280 at 2 hours after initial administration, 16.2±6.8 (n=246 2 days after final administration, 14.9±6.2 (n=248 3 days after final administration, 13.8±5.9 (n=242 4 days after final administration, 13.2±5.8 (n=221 7 days after initial

Switching to olanzapine long-acting injection from either oral olanzapine or any other antipsychotic: comparative post hoc analyses

Directory of Open Access Journals (Sweden)

Ciudad A

2013-11-01

Full Text Available Antonio Ciudad,1 Ernie Anand,2 Lovisa Berggren,3 Marta Casillas,4 Alexander Schacht,3 Elena Perrin5 1Department of Clinical Research and Development, Eli Lilly & Co, Madrid, Spain; 2Neuroscience Medical Affairs – EU, Lilly Research Centre, Windlesham, Surrey, UK; 3Global Statistical Sciences, Eli Lilly & Co, Bad Homburg, Germany; 4European Scientific Communications, Eli Lilly & Co, Madrid, Spain; 5Medical Department, Eli Lilly & Co, Suresnes, Paris, France Background: A considerable proportion of patients suffering from schizophrenia show suboptimal responses to oral antipsychotics due to inadequate adherence. Hence, they are likely to benefit from switching to a long-acting injectable formulation. These post hoc analyses assessed the clinical effects of switching to olanzapine long-acting injection (OLAI from either oral olanzapine (OLZ or other antipsychotics (non-OLZ. Methods: Post hoc analyses were done based on two randomized studies (one short-term, one long-term conducted in patients suffering from schizophrenia and treated with OLAI. The short-term study was an 8-week placebo-controlled, double-blind trial in acute patients, and the long-term study was a 2-year, oral olanzapine-controlled, open-label, follow-up of stabilized outpatients. Results: These analyses used data from 62 OLAI-treated patients (12 switched from OLZ, 50 from non-OLZ from the short-term study and 190 OLAI-treated patients (56 switched from OLZ, 134 from non-OLZ from the long-term study. Kaplan–Meier survival analyses of time to all-cause discontinuation of OLAI treatment did not differ significantly between OLZ and non-OLZ patients in the short-term study (P=0.209 or long-term study (P=0.448. Similarly, the proportions of OLZ and non-OLZ patients that discontinued OLAI were not statistically different in the short-term (16.7% versus 36.0%, respectively; P=0.198 or long-term (57.1% versus 47.8% respectively; P=0.238 studies. In the short-term study, no

To Conclude: India can aim big

Indian Academy of Sciences (India)

... Transmission and Distribution Losses. If 100 million middle class homes deploy 1 kW on rooftops. 100 GW peak power capacity added at homes alone; 40% of current peak power installed in India today. India must aim by 2030. To have 50% of its electric power from SOLAR; To have 50% of vehicles as Electric Vehicles ...

Vicarious revenge and the death of Osama bin Laden.

Science.gov (United States)

Gollwitzer, Mario; Skitka, Linda J; Wisneski, Daniel; Sjöström, Arne; Liberman, Peter; Nazir, Syed Javed; Bushman, Brad J

2014-05-01

Three hypotheses were derived from research on vicarious revenge and tested in the context of the assassination of Osama bin Laden in 2011. In line with the notion that revenge aims at delivering a message (the "message hypothesis"), Study 1 shows that Americans' vengeful desires in the aftermath of 9/11 predicted a sense of justice achieved after bin Laden's death, and that this effect was mediated by perceptions that his assassination sent a message to the perpetrators to not "mess" with the United States. In line with the "blood lust hypothesis," his assassination also sparked a desire to take further revenge and to continue the "war on terror." Finally, in line with the "intent hypothesis," Study 2 shows that Americans (but not Pakistanis or Germans) considered the fact that bin Laden was killed intentionally more satisfactory than the possibility of bin Laden being killed accidentally (e.g., in an airplane crash).

Chief of staff finance | Lillie | Scientia Militaria: South African Journal ...

African Journals Online (AJOL)

Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 12, No 2 (1982) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Chief of staff finance. Ashley C ...

On aeg, mil vajame enam leiba kui lilli / Ants Juske

Index Scriptorium Estoniae

Juske, Ants, 1956-2016

2009-01-01

Marge Monko isikunäitus "Leib ja lilled" Tallinnas Draakoni Galeriis 21. märtsini. Eksponeeritud fotod ja video "Nora õed". Kunstnik on majanduses ja tööhõives asetleidvaid muutusi uurides aluseks võtnud Narva Kreenholmi Manufaktuuri näited

Systematic review of raloxifene in postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia

Directory of Open Access Journals (Sweden)

Fujiwara S

2014-11-01

Full Text Available Saeko Fujiwara,1 Etsuro Hamaya,2 Masayo Sato,2 Peita Graham-Clarke,3 Jennifer A Flynn,2 Russel Burge41Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan; 2Lilly Research Laboratories Japan, Eli Lilly Japan K.K., Kobe, Japan; 3Global Health Outcomes, Eli Lilly Australia, Sydney, NSW, Australia; 4Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN, USAPurpose: To systematically review the literature describing the efficacy, effectiveness, and safety of raloxifene for postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia.Materials and methods: Medline via PubMed and Embase was systematically searched using prespecified terms. Retrieved publications were screened and included if they described randomized controlled trials or observational studies of postmenopausal Japanese women with osteoporosis or osteopenia treated with raloxifene and reported one or more outcome measures (change in bone mineral density [BMD]; fracture incidence; change in bone-turnover markers, hip structural geometry, or blood–lipid profile; occurrence of adverse events; and change in quality of life or pain. Excluded publications were case studies, editorials, letters to the editor, narrative reviews, or publications from non-peer-reviewed journals; multidrug, multicountry, or multidisease studies with no drug-, country-, or disease-level analysis; or studies of participants on dialysis.Results: Of the 292 publications retrieved, 15 publications (seven randomized controlled trials, eight observational studies were included for review. Overall findings were statistically significant increases in BMD of the lumbar spine (nine publications, but not the hip region (eight publications, a low incidence of vertebral fracture (three publications, decreases in markers of bone turnover (eleven publications, improved hip structural geometry (two publications, improved blood–lipid profiles (five publications, a low incidence of hot flushes

Dosing of U-100 insulin and associated outcomes among Medicare enrollees with type 1 or type 2 diabetes

Directory of Open Access Journals (Sweden)

Eby EL

2015-06-01

Full Text Available Elizabeth L Eby,1 Kate Van Brunt,2 Cynthia Brusko,3 Bradley Curtis,4 Maureen J Lage5 1Global Patient Outcomes and Real World Evidence, Eli Lilly and Co., Indianapolis IN USA; 2Eli Lilly and Co., Windlesham, UK; 3Lilly USA, LLC, Indianapolis, IN, USA; 4Eli Lilly and Co., Indianapolis, IN, USA; 5HealthMetrics Outcomes Research, LLC, Bonita Springs, FL, USA Objective: To examine costs, resource utilization, adherence, and hypoglycemic events among various doses of U-100 insulin regimens among elderly patients (age ≥65 years diagnosed with diabetes.Methods: Truven Health Analytics Medicare databases from January 1, 2008 through December 31, 2011 were utilized. General linear models with a gamma distribution and log link were used to examine costs, while logistic and negative binomial regressions were used to examine resource utilization and hypoglycemic events. Analyses controlled for patient characteristics, pre-period comorbidities, general health, and use of antidiabetic medications as well as index dose of insulin.Results: All-cause inpatient, emergency room, and outpatients costs, as well as diabetes-related inpatient costs, were highest among individuals who were treated with an index dose of 10–100 units/day followed by >300 units/day, while drug costs and total costs generally increased as index dosage increased. Resource utilization generally followed the same pattern as costs, with number of office visits increasing as the dose increased and the highest hospital length of stay, number of hospitalizations, number of emergency room visits, and number of diabetes-related hospitalizations were generally highest among those in the lowest and highest index dose cohorts. Compared to patients who initiated with an index dose of 10–100 units/day, all other patients were significantly less likely to achieve an adherence threshold of 80% based upon index dose range, and while those with an index dose of >100–150 units/day were

Эксклюзивный catwalk в квартале Baltika

Index Scriptorium Estoniae

2010-01-01

9. septembril näidati Baltika kvartalis loomeettevõtlusega tegelejatele välismaalt eesti noorte disainerite eksklusiivset moeetendust "Creative Incubator Fashion Show". Osalejateks Maki, Uma, Donkey Hot, Kalle Aasamäe ja Lilli Jahiloo. Show toimus rahvusvahelise moetegijate kokkutuleku raames, Loomeinkubaatori margi all

76 FR 16643 - NASA Advisory Council; Aeronautics Committee; Meeting

Science.gov (United States)

2011-03-24

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-024)] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory.... ADDRESSES: Thursday, April 14, 2011--NASA Dryden Flight Research Center (DFRC), Lilly Drive Building 4825...

Ramucirumab for Treating Advanced Gastric Cancer or Gastro-Oesophageal Junction Adenocarcinoma Previously Treated with Chemotherapy : An Evidence Review Group Perspective of a NICE Single Technology Appraisal

NARCIS (Netherlands)

Büyükkaramikli, N.; H.M. Blommestein (Hedwig); R. Riemsma (Rob); N. Armstrong (Nigel); F.J. Clay (Fiona); J. Ross (Janine); G. Worthy (Gill); J.L. Severens (Hans); J. Kleijnen (Jos); M.J. Al (Maiwenn)

2017-01-01

textabstractThe National Institute for Health and Care Excellence (NICE) invited the company that manufactures ramucirumab (Cyramza®, Eli Lilly and Company) to submit evidence of the clinical and cost effectiveness of the drug administered alone (monotherapy) or with paclitaxel (combination therapy)

Neljakümnes kevad : [luuletused] / Niina Obrezkova ; tlk. Arvo Valton

Index Scriptorium Estoniae

Obrezkova, Niina, 1965-

2006-01-01

Sisu: Neljakümnes kevad ; "Oleme kõik lapsed..." ; "Hommikvestlust pidada on hilja..." ; "Kingi mulle lilli sa..." ; "On mehi..." ; "Mälu mulle uksed avas ise..." ; "Kolm on valu südames..." ; "Helge pisar..." ; "Ei salahoovusi mus leidu..." "Miskitviisi...". Luuletused paralleelselt komi ja eesti keeles

Reis kosmosesse : [Floating-kambrist] / Marika Makarova

Index Scriptorium Estoniae

Makarova, Marika

2011-01-01

Ameerika psühholoogi John C. Lilly poolt kasutusele võetud Floating-kambrist ehk hõljumisvannist, mis aeglustab ajulaineid ning seeläbi aitab vähendada lihaspinget, stressi, ärevust, peavalusid, vererõhku ning parandada und, selgroo- ja kaelavigastusi, suurendada loovust ja heaolu jne

The orgasmic history of oxytocin: Love, lust, and labor

Directory of Open Access Journals (Sweden)

Navneet Magon

2011-01-01

Full Text Available Oxytocin has been best known for its roles in female reproduction. It is released in large amounts during labor, and after stimulation of the nipples. It is a facilitator for childbirth and breastfeeding. However, recent studies have begun to investigate oxytocin′s role in various behaviors, including orgasm, social recognition, bonding, and maternal behaviors. This small nine amino acid peptide is now believed to be involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterine contraction, milk ejection, maternal behavior, social bonding, stress and probably many more, which makes oxytocin and its receptor potential candidates as targets for drug therapy. From an innocuous agent as an aid in labor and delivery, oxytocin has come a long way in being touted as the latest party drug. The hormone of labor during the course of the last 100 years has had multiple orgasms to be the hormone of love. Many more shall be seen in the times to come!

On Sexualisation and Eroticisation: emancipation of love and lust

Directory of Open Access Journals (Sweden)

Cas Wouters

2017-12-01

Full Text Available This paper pursues understanding recent changes in the romantic and sexual relations of young people. Its perspective focuses on the emancipation of women and young people since the 1880s, a moment when social codes dominating the relations between women and men, parents and their children, changed towards greater leniency. Both had to learn how to become sexual subjects as well as sexual objects and to develop a gratifying balance between the two, in trial-and-error processes involving attempts at connecting sexual and relational intimacy in subsequent spurts of sexualisation and eroticisation. The paper sketches significant moments in these processes and raises the question of where we are now.

Uuenev Saaremaa kroonuküla (1841-1919) / Kersti Lust

Index Scriptorium Estoniae

Lust, Kersti, 1976-

2003-01-01

Ülevaade Saaremaa kroonumõisatest, maakorraldusest kroonukülas, vabadike maakasutusest ja seda reguleerinud korraldustest, raharendi sisseseadmisest ning seda reguleerinud õigusaktidest, talude päriseksostmist reguleerinud seadustest, talurahva maanõudmistest 1905. aastal, maaküsimusest aastatel 1917-1919

CURRICULUM MATTERS: Aims assessments and workplace needs

Science.gov (United States)

Black, Paul

1997-09-01

This paper attempts to consider the aims that undergraduate physics degree courses actually reflect and serve in the light of the employment patterns of graduates and of the expressed needs of employers. It reviews the results of analyses of what degree examinations actually test, and goes on to quote criticisms of their courses and radical proposals to change them adopted by the UK conference of physics professors. The discussion is then broadened by discussion of evidence, about the employment of graduates and about the priorities that some industrialists now give in the qualities that they look for when recruiting new graduates. The evidence leads to a view that radical changes are needed, both in courses and examinations, and that there is a need for university departments to work more closely with employers in re-formulating the aims and priorities in their teaching.

The Logic of Deferral: Educational Aims and Intellectual Disability

Science.gov (United States)

Taylor, Ashley

2018-01-01

The educational aims described by educational philosophers rarely embrace the full range of differences in intellectual ability, adaptive behavior, or communication that children exhibit. Because envisioned educational aims have significant consequences for how educational practices, pedagogy, and curricula are conceptualized, the failure to…

Database on Aims and Visions in the COINCO Corridor

DEFF Research Database (Denmark)

2005-01-01

This database contains aims and visions regarding overall regional development as well as more specific aims and visions related to transport and infrastructure in the Corridor Oslo-Göteborg-Copenhagen-Berlin. The sources used for this database are the most essential planning documents from Denmark...

AIM cryocooler developments for HOT detectors

Science.gov (United States)

Rühlich, I.; Mai, M.; Withopf, A.; Rosenhagen, C.

2014-06-01

Significantly increased FPA temperatures for both Mid Wave and Long Wave IR detectors, i.e. HOT detectors, which have been developed in recent years are now leaving the development phase and are entering real application. HOT detectors allowing to push size weight and power (SWaP) of Integrated Detectors Cooler Assemblies (IDCA's) to a new level. Key component mainly driving achievable weight, volume and power consumption is the cryocooler. AIM cryocooler developments are focused on compact, lightweight linear cryocoolers driven by compact and high efficient digital cooler drive electronics (DCE) to also achieve highest MTTF targets. This technology is using moving magnet driving mechanisms and dual or single piston compressors. Whereas SX030 which was presented at SPIE in 2012 consuming less 3 WDC to operate a typical IDCA at 140K, next smaller cooler SX020 is designed to provide sufficient cooling power at detector temperature above 160K. The cooler weight of less than 200g and a total compressor length of 60mm makes it an ideal solution for all applications with limited weight and power budget, like in handheld applications. For operating a typical 640x512, 15μm MW IR detector the power consumption will be less than 1.5WDC. MTTF for the cooler will be in excess of 30,000h and thus achieving low maintenance cost also in 24/7 applications. The SX020 compressor is based on a single piston design with integrated passive balancer in a new design achieves very low exported vibration in the order of 100mN in the compressor axis. AIM is using a modular approach, allowing the chose between 5 different compressor types for one common Stirling expander. The 6mm expander with a total length of 74mm is now available in a new design that fits into standard dewar bores originally designed for rotary coolers. Also available is a 9mm coldfinger in both versions. In development is an ultra-short expander with around 35mm total length to achieve highest compactness. Technical

The Teacher Is a Learner: Dewey on Aims in Education

Science.gov (United States)

Harðarson, Atli

2018-01-01

In Chapter VIII of "Democracy and Education", Dewey objects to all three of the following propositions: (1) education serves predefined aims; (2) Education serves aims that are external to the process of education; and (3) Education serves aims that are imposed by authority. From the vantage point of policy-makers and authors of…

Veel üks fond õpetajate toetuseks

Index Scriptorium Estoniae

2002-01-01

Inna Mathiesen annetas sihtasutusele Eesti Rahvuskultuuri Fond oma vanemate mälestuse jäädvustamiseks 300 000 krooni, millega pandi alus Lilly ja Hugo Pärnamäe Fondile. Sellega tahetakse toetada pedagooge, kes on koolis töötanud vähemalt kaks aastat

Külanäitemäng üllatas tenori ja kooriga / Liisi Seil

Index Scriptorium Estoniae

Seil, Liisi, 1971-

2009-01-01

17.-19. juulini toimus Lilli külas 4. Nava lava festival. Loeti luulet ja mängiti Jaak Kõdari kirjutatud mulgikeelset näitemängu "Kõik läheb mööda" ning lasteetendust "Hundi ja Rebase lend lõunanabale". Mõlemad lavastas Silvia Soro

78 FR 70581 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Science.gov (United States)

2013-11-26

... Eli Lilly & Company, South Pharmaceutical Sales Indianapolis, Representatives, Throughout the IN... identified by name by the International Trade Commission as a member of a domestic industry in an..., etc. 83,080 HSBC Bank USA, N.A., HSBC USA, Buffalo, NY...... September 12, 2012. HSBC North America...

Maalitud majad Zalipies / Marje Tammert

Index Scriptorium Estoniae

Tammert, Marje

2003-01-01

Poola Zalipie külas on elumajad ja kõrvalhooned dekoreeritud erksavärviliste lillebukettidega. Lilli ja linde näeb aknaluukidel, aiapostidel, kaevudel, käimlatel jm. Küla muuseumis on lilledega kaetud kogu interjöör, kapid, nõud ja tikitud tekstiilid. 4 ill

Make love and war ehk ükssarvede ilmumine Tallinnasse = Make love and war, or the unicorns' advent in Tallinn / Rebeka Põldsam

Index Scriptorium Estoniae

Põldsam, Rebeka, 1989-

2012-01-01

Tallinna linnainstallatsioonide festivali "LIFT11" installatsioonist "Queer-kleepekavihik". Kuraatorid Anna-Stina Treumund ja Jaanus Samma. Autorid Helin Tikerpuu, Katia Weber Piscitelli, Ly Lestberg, Mare Tralla, Ott Pilipenko, Mae Köömnemägi, Andreas Kalkun, Rebeka Põldsam, Lilli-Krõõt Repnau, Aet Kuusik, Jaanus Samma

DESAIN KOMUNIKASI DAKWAH VISUAL ANIMASI 2D UNTUK ANAK

Directory of Open Access Journals (Sweden)

Mokhamad Mahfud

2017-04-01

Full Text Available Dakwah activities as a communication process of delivering the teachings of Islam's ideal has no power to change people for the better. There are many causal factors, one of them is because of propagandas that has been done tends to be cold, impersonal, and is only informative sheer, yet using less effective communication ethics. A visual cultural revolution is now growing rapidly, unfortunately its dominated by capitalists and worshipers of lust. For example, nearly all visual ads is using the interest of sensuality and lust to lure customers. On the billboards, media newspapers, magazines, television and other media, visual communication seemed to be a valuable garbage, and this is very dangerous, especially if in the consumption of children who are mentally and immature psyche. The Effects of visual "value-free" communication can damage the sense of children as the next generation, we are slowly showed on-aurast which makes Muslims become stupid. This study aims to provide a creative space to explore the lives of children for the purpose of providing religious materials in SDN Monggang Pendowoharjo Sewon Bantul. 2D animation design is expected to give a message to children that religious material is not complicated but enjoyable. And the use of cartoon animation techniques in the making is in fact, expecting the material to be delivered to children to be light for their minds and appropriate with their entertainment media which is television. This research Visual Communication Design using 2d Animation For Children is using descriptive study which is a qualitative research method that analyze the words or sentences and separate it by category for the conclusion. Qualitative research aims to explain the phenomenon in detail and in-depth data collection that focuses on quality rather than the quantity of data. The results of this study is that the creation of 2D animation is effective to be a dakwah media for children that will be made with a

The compatibility between extension aims of staff and their ...

African Journals Online (AJOL)

This pilot investigation was done to investigate the compatibility between extension aims of extension staff and those of their employer. It shows that only 50 percent of respondents have an acceptable understanding of the official aims (vision), and that none of the components of the official vision has sufficient compatibility ...

Sleep disturbance in mental health problems and neurodegenerative disease

Directory of Open Access Journals (Sweden)

Anderson KN

2013-05-01

Full Text Available Kirstie N Anderson1 Andrew J Bradley2,3 1Department of Neurology, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK; 2Eli Lilly and Company Limited, Lilly House, Basingstoke, UK; 3Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK Abstract: Sleep has been described as being of the brain, by the brain, and for the brain. This fundamental neurobiological behavior is controlled by homeostatic and circadian (24-hour processes and is vital for normal brain function. This review will outline the normal sleep–wake cycle, the changes that occur during aging, and the specific patterns of sleep disturbance that occur in association with both mental health disorders and neurodegenerative disorders. The role of primary sleep disorders such as insomnia, obstructive sleep apnea, and REM sleep behavior disorder as potential causes or risk factors for particular mental health or neurodegenerative problems will also be discussed. Keywords: sleep, mental health, neurodegenerative disorders, cognition

The promotion of olanzapine in primary care: an examination of internal industry documents.

Science.gov (United States)

Spielmans, Glen I

2009-07-01

Media reports have discussed how olanzapine was marketed off-label for dementia and subsyndromal bipolar disorder. Much of this marketing occurred in primary care settings. However, these reports have provided few details. In legal proceedings, Lilly disclosed internal documents that detail the strategies utilized to market olanzapine. The current paper addresses the marketing of olanzapine in detail based upon a review of these documents. All 358 documents released by Lilly are publicly available online. Documents were utilized for this review if they were relevant to the marketing of olanzapine in primary care settings in the United States. It was found that olanzapine was marketed off-label in primary care settings for relatively mild symptoms that were framed as bipolar disorder and schizophrenia. A key strategy in this campaign was the use of hypothetical patient profiles in detailing visits, most of which clearly failed to meet diagnostic criteria for any recognized mental disorder. Evidence emerged that olanzapine was also marketed off-label as a treatment for dementia.

A cost-effectiveness analysis of first-line induction and maintenance treatment sequences in patients with advanced nonsquamous non-small-cell lung cancer in France

Directory of Open Access Journals (Sweden)

Taipale K

2017-08-01

Full Text Available Kaisa Taipale,1 Katherine B Winfree,2 Mark Boye,2 Mickael Basson,3 Ghassan Sleilaty,4 James Eaton,5 Rachel Evans,5 Christos Chouaid6 1Global Patient Outcomes and Real World Evidence International, Oy Eli Lilly Finland AB, Helsinki, Finland; 2Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Indianapolis, IN, USA; 3Corporate Affairs, Lilly France, Neuilly-sur-Seine, 4Bio-Medicines Medical Affairs, Lilly France, Neuilly-sur-Seine, France; 5ICON Health Economics and Epidemiology, ICON Plc, Milton Park, UK; 6Thoracic Oncology, Service de Pneumologie, Centre Hospitalier Intercommunal Créteil, Créteil, France Background: Comparative effectiveness and cost-effectiveness data for induction–maintenance (I–M sequences for the treatment of patients with nonsquamous non-small-cell lung cancer (nsqNSCLC are limited because of a lack of direct evidence. This analysis aimed to compare the cost-effectiveness of I–M pemetrexed with those of other I–M regimens used for the treatment of patients with advanced nsqNSCLC in the French health-care setting. Materials and methods: A previously developed global partitioned survival model was adapted to the France-only setting by restricting treatment sequences to include 12 I–M regimens most relevant to France, and incorporating French costs and resource-use data. Following a systematic literature review, network meta-analyses were performed to obtain hazard ratios for progression-free survival (PFS and overall survival (OS relative to gemcitabine + cisplatin (induction sequences or best supportive care (BSC (maintenance sequences. Modeled health-care benefits were expressed as life-years (LYs and quality-adjusted LYs (QALYs (estimated using French EuroQol five-dimension questionnaire tariffs. The study was conducted from the payer perspective (National Health Insurance. Cost- and benefit-model inputs were discounted at an annual rate of 4%. Results: Base-case results showed pemetrexed

Corruption and development: an inquiry into nature and causes and suggested remedy

OpenAIRE

Islahi, Abdul Azim

2000-01-01

Recognition for corruption as one of the main obstacles in the way of economic development is a rather recent development in the discipline of Development Economics. Due to wide-spread corruption only a small portion of development money reaches to the public. The reasons behind the corruption culture are numerous such as rejection of moral and spiritual values, greed and lust of money, rising election expenses, no belief in accountability to God or responsibility to the masses. With these st...

Negotiating Love and Work: A Critical Ethnography of A Gay Porn Star

OpenAIRE

Johnson Jr., Michael

2013-01-01

This ethnography offers a glimpse into one person’s pornographic film career, thus rendering visible a frequently invisible sub-textual accounting of the adult film industry. And in so doing, I offer some critiques about how popular constructions of what “love” and affection mean are always tentatively related to our relationship with and exposure to pornography. This research thus argues that our popular understanding of sexual desire, lust, and love are in constant states of flux as sex is ...

Neutral-beam aiming and calorimetry for MFTF-B

International Nuclear Information System (INIS)

Goldner, A.I.; Margolies, D.

1981-01-01

The vessel for the Tandem Mirror Fusion Test Facility (MFTF-B) will have up to eleven 0.5-s-duration neutral-beam injectors for the initial heating of the MFTF-B plasma. Knowing the exact alignment of the beams and their total power is critical to the performance of the experiment. Using prototype aiming and calorimetry systems on the High Voltage Test Stand (HVTS) at Lawrence Livermore National Laboratory (LLNL), we hope to prove our ability to obtain an aiming accuracy of +-1 cm at the plasma and a calorimetric accuracy of +-5% of the actual total beam energy

Teaching Design Education for Cultural, Pedagogical, and Economic Aims

Science.gov (United States)

Vande Zande, Robin

2010-01-01

The aims of educating for economic, cultural, and pedagogical purposes have existed since the early inception of art education. Looking at how and why these aims evolved in the early era of art and design education has potential for better understanding how and why design should be incorporated into the art education curricula today. This article…

The Aims of Education and the Leap of Freedom

Science.gov (United States)

Yun, SunInn

2014-01-01

This paper considers the place of freedom in discussions of the aims of education. Bearing in mind remarks of R.S. Peters to the affect that the singling out of aims can "fall into the hands of rationalistically minded curriculum planners", it begins by considering the views of Roland Reichenbach regarding Bildung and his account of this…

Turbulent Convection in an Anelastic Rotating Sphere: A Model for the Circulation on the Giant Planets

Science.gov (United States)

2008-06-01

Raffaele Ferrari, Adam Showman, Dick Lindzen, Baylor Fox-Keiper, Jonathan Lilly, Tapio Schneider, Carl Wunsch and Bill Hubbard. Particularly I thank Jean...Cuzzi, J., Pollack, J. B.. Danielson, G. E., Ingersoll, A., Davies, M. E., Hunt, G. E., Morrison, D., Owen, T.. Sagan , C., Veverka, J., Strom, R

Habent sua fata motae picturae / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2008-01-01

1968. aastal Eesti Telefilmis valminud 3-osaline mängufilm "Pimedad aknad" Lilli Prometi jutustuse "Pimedate akende aegu" järgi (režissöör Tõnis Kask) restaureeriti ja helindati uuesti (restaureerisid ETV ja OÜ Profilm). Lisatud "1965-1974: Eesti televisioon õitseb" - olulist ETVs neil aastail

Humalog Mix25 improves 24-hour plasma glucose profiles ...

African Journals Online (AJOL)

Most patients with type 2 diabetes mellitus (T2DM) administer insulin twice daily, yet many use premixed insulin preparations (Lilly, data on file). Premixtures of short- or rapid- acting and intermediate-acting insulins twice daily are commonly used, offering convenience and increased dosing accuracy compared with insulins ...

Translational medicine and drug discovery

National Research Council Canada - National Science Library

Littman, Bruce H; Krishna, Rajesh

2011-01-01

..., and examples of their application to real-life drug discovery and development. The latest thinking is presented by researchers from many of the world's leading pharmaceutical companies, including Pfizer, Merck, Eli Lilly, Abbott, and Novartis, as well as from academic institutions and public- private partnerships that support translational research...

A more rational approach to new-product development.

Science.gov (United States)

Bonabeau, Eric; Bodick, Neil; Armstrong, Robert W

2008-03-01

Companies often treat new-product development as a monolithic process, but it can be more rationally divided into two parts: an early stage that focuses on evaluating prospects and eliminating bad bets, and a late stage that maximizes the remaining candidates' market potential. Recognizing the value of this approach, Eli Lilly designed and piloted Chorus, an autonomous unit dedicated solely to the early stage. This article demonstrates how segmenting development in this way can speed it up and make it more cost-effective. Two classes of decision-making errors can impede NPD, the authors say. First, managers often ignore evidence challenging their assumptions that projects will succeed. As a result, many projects go forward despite multiple red flags; some even reach the market, only to fail dramatically after their introduction. Second, companies sometimes terminate projects prematurely because people fail to conduct the right experiments to reveal products' potential. Most companies promote both kinds of errors by focusing disproportionately on late-stage development; they lack the early, truth-seeking functions that would head such errors off. In segmented NPD, however, the early-stage organization maintains loyalty to the experiment rather than the product, whereas the late-stage organization pursues commercial success. Chorus has significantly improved NPD efficiency and productivity at Lilly. Although the unit absorbs just one-tenth of Lilly's investment in early-stage development, it delivers a substantially greater fraction of the molecules slated for late Phase II trials--at almost twice the speed and less than a third of the cost of the standard process, sometimes shaving as much as two years off the usual development time.

Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients

Directory of Open Access Journals (Sweden)

Novick D

2016-04-01

Full Text Available Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Indianapolis, IN, USA Objective: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD (n=714. Methods: The 17-item Hamilton Depression Scale (HAMD-17, overall severity, somatic symptoms, and quality of life (QOL (EuroQOL Questionnaire-5 Dimensions [EQ-5D] were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. Results: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723–0.951]. Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045–0.001]. Conclusion: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression. Keywords: depression, anxiety, Asia, observational, outcomes

Ecological radiation monotoring in NPP region, aims and tasks

International Nuclear Information System (INIS)

Egorov, Yu.A.

1986-01-01

Aims and tasks of ecological radiation monitoring in the NPP region are discussed. The aims of monitoring are: to determine possible sequences of NPP radioactive release effects on ecosystems, taking place on the background of chemical and thermal pollution to develop standard of radiation effect on ecosystems; the aims includes also obtaining of information for forecasting and evaluating long-term radiation effects, establishment of factors characterizing the ecosystem state, establishment of a combined effect of radioactive wastes with chemical and thermal ones. Finally, the aim of monitoring consists in providing the natural object conservation in the NPP region under optimal operation conditions. Thus it is necessary to solve the following problems: to observe systematically release, transport and transformation, when transporting radioactive and chemical contaminants in terrestial and aquatic biocenoses, as well as injection and transport in them of waste heat; to observe systematically the natural physico-chemical, chemico-biological processes affecting the injection and transport of contaminants in ecosystem components; to observe systematically the natural and, probably, antropogenic processes; to carry out systematically observations of the ecosystem state in the NPP region and eco-systems-monitors

Pragmatics and the aims of language evolution.

Science.gov (United States)

Scott-Phillips, Thomas C

2017-02-01

Pragmatics has historically played a relatively peripheral role in language evolution research. This is a profound mistake. Here I describe how a pragmatic perspective can inform language evolution in the most fundamental way: by making clear what the natural objects of study are, and hence what the aims of the field should be.

Universal Authenticated Item Monitoring System (AIMS) second generation equipment

International Nuclear Information System (INIS)

Schoeneman, J.L.; Baumann, M.J.; Fox, L.J.; Jenkins, C.D.; Perlinsk, A.W.

1992-01-01

Sandia National Laboratories (SNL) is in the final stages of developing a Universal Authenticated Item Monitoring System (AIMS). When completed, AIMS will provide applicable agencies in the US government, and those in the International arena, with a secure and convenient method of monitoring the physical status of selected items. The benefit derived from this development activity will be the commercial availability of an item monitoring system with the capability for ''quick set-up'' monitoring, as well as long-term unattended monitoring. The AIMS includes a variety of sensors, a robust and authenticated radio frequency (RF) communication link, a Receiver Processing Unit (RPU), and an inspector-friendly personal computer (PC) interface for collecting, sorting, viewing and archiving pertinent event histories. The system will provide the capability to monitor selected items in a real-time mode, a remotely interrogated mode, and a stand-alone, unattended data collection mode. The sensor suite under development includes advanced motion sensors, interior volumetric intrusion sensors, Re-usable, In-situ Verifiable Authenticated (RIVA) fiber-optic seal sensors, generic utility sensors (to accommodate contact closure inputs), and radiation and environmental sensors. A new generation authentication algorithm recently has been developed that provides a high degree of system security 121. The AIMS has potential safeguards applications in the areas of arms control and treaty verification military asset control, International Atomic Energy Agency (IAEA) and Euratom safeguards verification activities, as well as domestic nuclear safeguard activities. Commercial applications could include high-value inventory control and security systems. This paper describes the second-generation AIMS along with its recently expanded sensor suite and enhanced data collection capabilities

Harry Potter ja Scarlett käivad kohut / Ilona Martson

Index Scriptorium Estoniae

Martson, Ilona, 1970-

2001-01-01

Alice Randalli romaan "Tuul on läinud" - samad sündmused kui Margaret Mitchelli romaanis "Tuulest viidud", ainult neegerorjade vaatevinklist. Nancy Stofferi raamatud "Larry Potter ja tema parim sõber Lilly" ja "Legend Rah'ist ja Mugudest" ilmusid 1984. a. Joanne Kathleen Rowlingi "Harry Potter" lood aga valmisid hiljem

Drug Advertising and the FDA.

Science.gov (United States)

Levesque, Cynthia

With increases in consumer focused advertising for prescription drugs, the Federal Drug Administration has renewed efforts to protect the public from false advertising. In 1982, it charged that the press kits Eli Lilly and Company distributed to reporters on its new antiarthritis drug, Oraflex, misrepresented the product. It recommended that Lilly…

Promotion of Critical Thinking in Clinical Nursing Post Conferences: A Peer Interactive Approach

Science.gov (United States)

Stevens, Joanne

2009-01-01

Several workshops presented at the 2005 Lilly Conference on College Teaching in Oxford, Ohio, provided the inspiration for redesigning the clinical post conference for a foundational nursing course. Given the complexity and acuity of patient conditions today, fostering critical thinking in student nurses is central to quality patient care. The…

Similar Efficacy and Safety of Basaglar® and Lantus® in Patients with Type 2 Diabetes in Age Groups (< 65 Years, ≥ 65 Years): A Post Hoc Analysis from the ELEMENT-2 Study.

Science.gov (United States)

Pollom, Robyn K; Costigan, Timothy; Lacaya, Lyndon B; Ilag, Liza L; Hollander, Priscilla A

2018-04-01

To compare efficacy and safety of Basaglar ® [insulin glargine 100 units/mL; LY insulin glargine (LY IGlar)] to Lantus ® [insulin glargine 100 units/mL; SA insulin glargine (SA IGlar)] in older (≥ 65 years) or younger (Eli Lilly and Company and Boehringer-Ingelheim.

The Ripple Effect: Lessons from a Research and Teaching Faculty Learning Community

Science.gov (United States)

Hershberger, Andrew; Spence, Maria; Cesarini, Paul; Mara, Andrew; Jorissen, Kathleen Topolka; Albrecht, David; Gordon, Jeffrey J.; Lin, Canchu

2009-01-01

Building upon a related 2005 panel presentation at the 25th annual Lilly Conference on College Teaching, Miami University, Oxford, Ohio, the authors, several tenure-track assistant professors and tenured associate professors who have participated in a Research and Teaching Faculty Learning Community at Bowling Green State University, share their…

IntegrasiTauhid dan Akhlak dalam Pandangan Fakhruddîn Ar-Razi

OpenAIRE

Jarman Arroisi

2013-01-01

This paper is based on deviation of mindset, attitudes, and human behavior that happened this nowadays. The deviation can be captured through the attitudes and behavior that is no longer based on human nature, but based on the lust. As a result, there is a moral degradation that led to the multi- dimensional crisis. Actually, the previous Islamic scholars, such as Fakhruddîn ar-Râzî had stressed the importance of establishing the mindset, attitude, and behavior on the basis of tawhid or human...

'I have a picture of the Monster!': Il mostro di Frankenstein and the search for Italian horror cinema

OpenAIRE

Hunter, Russ

2017-01-01

Typically accounts of Italian horror cinema have highlighted the production and release of Riccardo Freda's 'I vampiri' (Lust of the Vampire) in the late 1950s as marking the beginning of Italian engagement with the horror genre. The logic that follows is often that the nature of fascist censorship impeded any explorations of the genre in the 1920s and 1930s and that in the post war period it was only the commercial success of Hammer Horror that tempted Italian producers to venture into horro...

Curbing Abuses of Legal Power in the Society

OpenAIRE

Tajudeen Ojo Ibraheem

2015-01-01

In a world characterized by greed and the lust for power and its attendant trappings, abuse of legal power is nothing new to most of us. Legal abuses of power abound in all fields of human endeavour. Accounts of such abuses dominate the mass media and for the average individual, no single day goes by without his getting to hear about at least one such occurrence. This paper briefly looks at the meaning of legal power, what legal abuse is all about, its causes, and some of...

The aims of transfer prices formation

Directory of Open Access Journals (Sweden)

Tomašević Stevan

2013-01-01

Full Text Available More than two-thirds of today's world trade comprises of transactions between related legal persons. Prices for the above-mentioned transactions within legal person or group of related legal persons are called transfer pricing. The aim of this paper is to present the transfer prices as well as the main objectives of transfer pricing. Also, this paper explains application of transfer pricing in the Republic of Serbia and the normative rules that cover the issue of transfer pricing, their determination and their application in the calculation. Overall, there has been a great deal of attention paid to the transfer pricing in national and international levels.

Ethics and aims in psychotherapy: a contribution from Kant.

Science.gov (United States)

Callender, J S

1998-08-01

Psychotherapy is an activity which takes many forms and which has many aims. The present paper argues that it can be viewed as a form of moral suasion. Kant's concepts of free will and ethics are described and these are then applied to the processes and outcome of psychotherapy. It is argued that his ideas, by linking rationality, free will and ethics into a single philosophical system, offer a valuable theoretical framework for thinking about aims and ethical issues in psychotherapy.

Networked Success and Failure at Hybritech

Science.gov (United States)

Jones, Mark Peter

2011-01-01

The author presents an historical account of scientific work conducted at a commercial biotech firm in San Diego called Hybritech. It tells of disruptions in research programs following the acquisition of the company by the pharmaceutical giant Eli Lilly in 1986. The story centers on responses to an organizational challenge that research managers…

In vitro activity of a new 'higher-Iactam' antibacterial agent LY 193239

African Journals Online (AJOL)

1991-03-16

Mar 16, 1991 ... penicillin. Antimicrobial agents. Solutions of LY 193239 (supplied by Eli Lilly) and tetracycline were freshly prepared in sterile distilled water. Rifampicin was dissolved in dimethyl sul- phoxide and diluted in water. Ampicillin and penicillin were prepared in 0,05M phosphate buffer with final pH 7,0. MICs.

Language Ideology Change over Time: Lessons for Language Policy in the U.S. State of Arizona and Beyond

Science.gov (United States)

Fitzsimmons-Doolan, Shannon

2018-01-01

In the U.S. state of Arizona, language minority students who are English learners attend schools governed by a restrictive medium of instruction (MOI) language policy (LP). Educators and educational researchers widely agree that effective reforms of this policy are urgently needed (e.g., Arias & Faltis, 2012; Lawton, 2012; Lillie, 2016).…

Americans aim to overhaul science teaching by 2061

CERN Document Server

1990-01-01

Project 2061 is a long-term initiative by the AAAS to reform classroom science. Deputy director Walter Gillespie claims that the aim is for schools to teach less content but teach it better (1/2 page).

Specific Reaction Patterns to Distinct Positive Emotional Cues Related to Incentive Motivation in Dependence of the Taq1A-Polymorphism: Molecular Genetic Associations of Early and Late Event-Related Potentials.

Science.gov (United States)

Munk, Aisha J L; Wielpuetz, Catrin; Osinsky, Roman; Müller, Erik M; Grant, Phillip; Hennig, Jürgen

2016-01-01

Early and late event-related potential (ERP) responses, representing early subconscious and late motivational processes, were recorded for positive emotional words related to 'wanting' and 'liking', in dependence of the dopamine-related Taq1A genotype (ANKK1/DRD2). Research suggests that 'wanting' as opposed to 'liking' is related to dopaminergic processes. Therefore, it was hypothesized that risk allele carriers of the Taq1A polymorphism exhibit late ERP changes in reaction to words representing incentive motivation, i.e. 'wanting' (word categories 'lust' and 'anticipation'), but not to words representing 'liking' ('closeness'). Seventy-two male participants performed an emotional-word Stroop task during EEG recording and were genotyped according to the Taq1A polymorphism of ANKK1/DRD2. Positive emotional words related to anticipation and lust revealed blunted responses in the late positive potential (LPP) in carriers of the A1 allele, an effect absent in response to 'liking'-related words. These differences were not evident in the earlier posterior negativity (EPN). As no differences in dependence of the Taq1A genotype were observed in reaction to 'wanting'- and 'liking'-related words in the EPN, but merely in the LPP, it can be assumed that incentive-motivational stimuli only modify motivation-related ERP responses in carriers of the A1 allele of the Taq1A polymorphism, indicating the role of dopamine in late ERP components. © 2016 S. Karger AG, Basel.

Positive psychological interventions aimed at enhancing psychological ownership

NARCIS (Netherlands)

van Zyl, Llewellyn; van der Vaart, Leoni; Stemmet, Lehan; Olckers, Chantal; van Zyl, Llewellyn; van der Vaart, Leoni

2017-01-01

Interventions aimed at the enhancement of positive organisational behaviours, within organisational contexts, are imperative for creating and sustaining a high-performance culture, where individual and organisational strengths are optimized and top-talent retained. Psychological ownership, one form

S3T working group. Report 1: group aims

International Nuclear Information System (INIS)

Pouey, M.

1983-04-01

The work group S3T which is aimed to designing and developing devices using unconventional holographic optics is presented. These devices find applications that are classified here in four items high resolution spectrometers, high definition imaging, high flux devices, metrology and interferometry. The problems to solve and the aims of the group in each of these cases are presented. Three synthesis of lectures are in this report. The main one concerns stigmatism conditions of concave holographic gratings used in normal incidence. This new process of focusing is very interesting for hot plasma diagnostics [fr

Clinical response and hospital costs associated with the empirical use of vancomycin and linezolid for hospital-acquired pneumonia in a Chinese tertiary care hospital: a retrospective cohort study

Directory of Open Access Journals (Sweden)

Song Y

2014-10-01

Full Text Available Yuanlin Song,1,* Yicheng Yang,2,* Wendong Chen,3,4 Wei Liu,2 Kai Wang,2 Xuehai Li,5 Ke Wang,2 Manny Papadimitropoulos,3,6 William Montgomery7 1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 2Lilly Suzhou Pharmaceutical Co, Ltd, Shanghai Branch, Shanghai, People's Republic of China; 3Division of Social and Administrative Pharmacy, Leslie Dan Faculty of Pharmacy, University of Toronto, 4Normin Health, Toronto, ON, Canada; 5VitalStrategic Research Institute, Shanghai, People's Republic of China; 6Global Health Outcomes Research, Eli Lilly, Indianapolis, IN, USA; 7Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia *These authors contributed equally to this work Aims: To evaluate clinical outcomes and allocation of hospital costs associated with empirical use of vancomycin or linezolid for hospital-acquired pneumonia (HAP in the People's Republic of China. Methods: Hospital episodes including HAP treated by vancomycin or linezolid between 2008 and 2012 in a Chinese tertiary care hospital were retrospectively identified from hospital administrative databases. Propensity score methods created best-matched pairs for the antibiotics. The matched pairs were used for adjusted comparisons on clinical response and allocation of hospital costs. Multiple regression analyses adjusting residual imbalance after matching were performed to confirm adjusted comparisons. Results: Sixty matched pairs were created. Adjusted comparisons between vancomycin and linezolid showed similar clinical response rates (clinical cure: 30.0% versus 31.7%, respectively; P=0.847; treatment failure: 55.0% versus 45.0%, respectively; P=0.289 but a significantly lower in-hospital mortality rate for vancomycin (3.3% versus 18.3%, respectively; P=0.013. After further adjusting for the imbalanced variables between matched treatment groups, the risks of treatment failure associated with the two antibiotics were comparable (odds ratio: 1.139; P=0.308 and there was

The Tectonics of Love in Leo Tolstoy’s Resurrection

Directory of Open Access Journals (Sweden)

Głąb Anna

2016-09-01

Full Text Available The text analyzes Leo Tolstoy’s Resurrection focusing on the feelings expressed in the novel. It focuses on: (I the ways in which the content of the novel is expressed through artistic means; (II Tolstoy’s anthropology; (III the notion of love presented by Ronald de Sousa in his last book Love. A Very Short Introduction: the difference between love and mood or emotion; the classification of love (philia, storge, agape, eros; the distinction between love and lust; love as a reason-free desire; and the notion of the historicity of love.

Recovery in patients with major depressive disorder (MDD: results of a 6-month, multinational, observational study

Directory of Open Access Journals (Sweden)

Novick D

2017-10-01

Full Text Available Diego Novick,1 William Montgomery,2 Ellen Vorstenbosch,3 Maria Victoria Moneta,3 Héctor Dueñas,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly de Mexico, Mexico City, Mexico Abstract: Not all individuals treated for major depressive disorder (MDD achieve recovery. This observational study examined the recovery rates in MDD patients and the patient characteristics associated with achieving recovery in a naturalistic clinical setting. Recovery was defined as having both clinical and functional remission. Data for this post hoc analysis were taken from a 24-week prospective, observational study that involved 1,549 MDD patients. Clinical remission was assessed using the 16-item Quick Inventory of Depressive Symptomatology Self-Report and functional remission through the Sheehan Disability Scale and no days of reduced productivity in the previous week. Generalized estimating equation regression models were used to examine the baseline factors associated with recovery during follow-up. Clinical and functional remission was achieved in 70.6% and 56.1% of the MDD patients, respectively. MDD patients who achieved recovery (52.1% were significantly less likely to have impaired levels of functioning, concurrent medical or psychiatric conditions, low levels of education, or nonadherence to therapy at follow-up. The level of functioning during the index episode seems to be a better predictor of recovery than symptom severity. Therefore, the level of functioning should be considered while determining recovery from depression. Keywords: remission, functional impairment, clinical remission, course of illness, disability, predictors

Comparison of patients undergoing switching versus augmentation of antipsychotic medications during treatment for schizophrenia

Directory of Open Access Journals (Sweden)

Ascher-Svanum H

2012-03-01

Full Text Available Haya Ascher-Svanum, Alan JM Brnabic, Anthony H Lawson, Bruce J Kinon, Virginia L Stauffer, Peter D Feldman, Katarina KelinLilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USAAbstract: It is often difficult to determine whether a patient may best benefit by augmenting their current medication or switching them to another. This post-hoc analysis compares patients’ clinical and functional profiles at the time their antipsychotic medications were either switched or augmented. Adult outpatients receiving oral antipsychotic treatment for schizophrenia were assessed during a 12-month international observational study. Clinical and functional measures were assessed at the time of first treatment switch/augmentation (0–14 days prior and compared between Switched and Augmented patient groups. Due to low numbers of patients providing such data, interpretations are based on effect sizes. Data at the time of change were available for 87 patients: 53 Switched and 34 Augmented. Inadequate response was the primary reason for treatment change in both groups, whereas lack of adherence was more prevalent in the Switched group (26.4% vs 8.8%. Changes in clinical severity from study initiation to medication change were similar, as indicated by Clinical Global Impressions–Severity scores. However, physical and mental component scores of the 12-item Short-Form Health Survey improved in the Augmented group, but worsened in the Switched group. These findings suggest that the patient’s worsening or lack of meaningful improvement prompts clinicians to switch antipsychotic medications, whereas when patients show some improvement, clinicians may be more likely to try bolstering the improvements through augmentation. Current findings are consistent with physicians’ stated reasons for switching versus augmenting antipsychotics in the treatment of schizophrenia. Confirmation of these findings requires further research

Pildid räägivad lugusid, vorstid samuti / Andry Ervald

Index Scriptorium Estoniae

Ervald, Andry

2006-01-01

Koomiksinäitus Rakvere galeriis. Osa võtavad Peeter Krosmann (1971), Kristel Maamägi (1986), Lilli-Krõõt Repnau (1982), Elina Sildre (1980), Joonas Sildre (1980), Veiko Tammjärv (1967), Paco Ulman (1980), Edvin Aedma ja rühmitus Endorfin Fractured Communications. Kristel Maamägi oma töödest

A Long Island Consortium Takes Shape. Occasional Paper No. 76-1.

Science.gov (United States)

Taylor, William R.

This occasional paper, the first in a "new" series, describes the background, activities, and experiences of the Long Island Consortium, a cooperative effort of two-year and four-year colleges committed to organizing a model program of faculty development. The consortium was organized under an initial grant from the Lilly Endowment. In May and…

Collaborative learning in an academic writing workshop

African Journals Online (AJOL)

Hennie

claims that modelling, offering a critique of think- ing out aloud .... Maxwell, 1994) by writing a sentence beginning with 'I want ... because when you talk to people in a language which is ..... workshop as “most successful”, particularly as it .... Baltimore: The John Hopkins ... Coffin C, Curry MJ, Goodman S, Hewings A, Lillis TM.

Résultats de recherche | Page 29 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Transition et amélioration des indices mondiaux de philanthropie. Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana.

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.

Science.gov (United States)

Dang, Eric V; McDonald, Jeffrey G; Russell, David W; Cyster, Jason G

2017-11-16

Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here, we demonstrate that production of 25-hydroxycholesterol (25-HC) by macrophages is required to prevent inflammasome activation by the DNA sensor protein absent in melanoma 2 (AIM2). We find that in response to bacterial infection or lipopolysaccharide (LPS) stimulation, macrophages upregulate Ch25h to maintain repression of SREBP2 activation and cholesterol synthesis. Increasing macrophage cholesterol content is sufficient to trigger IL-1β release in a crystal-independent but AIM2-dependent manner. Ch25h deficiency results in cholesterol-dependent reduced mitochondrial respiratory capacity and release of mitochondrial DNA into the cytosol. AIM2 deficiency rescues the increased inflammasome activity observed in Ch25h -/- . Therefore, activated macrophages utilize 25-HC in an anti-inflammatory circuit that maintains mitochondrial integrity and prevents spurious AIM2 inflammasome activation. Copyright © 2017 Elsevier Inc. All rights reserved.

Determination of aims military-technical policy of Ukraine

Directory of Open Access Journals (Sweden)

O. F. Salnikova

2014-06-01

Full Text Available In the article the aims of military-technical policy are considered. Determination of aims (tasks of military-technical policy, its maintenance, requirements to it and directions of its further development it must come true by the analysis of different factors of external and internal environment. Among such factors: geopolitical and military-political position of Ukraine and its military doctrine; realized and operating programs of development (reformation of the soldiery forming and them technical rigging; terms of future military operations and progress of their maintenance, forms, methods and characteristic signs of battle actions trend; substantive provisions of art of war; conceptions, theories and doctrines of battle application of the soldiery forming of the different states; resources dedicated by the state on development of military-technical sphere and others like that. The fundamental chart of sequence of forming of public military-technical policy is presented in the article.

250 kV aim for hvdc valves

Energy Technology Data Exchange (ETDEWEB)

1966-06-01

Development now being carried out by ASEA is aimed at increasing the normal operating voltage for a mercury arc valve to 250 kV dc. The maximum direct voltage per valve group, with one valve in each arm of the bridge, is 125 kV for equipment already in operation in New Zealand, Japan, and Konti Scan. Valves for 130 kV and 133 kV operation are under construction for the Vancouver and the Pacific Intertie 1 links.

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.

Science.gov (United States)

Sanchez, Gina A Montealegre; Reinhardt, Adam; Ramsey, Suzanne; Wittkowski, Helmut; Hashkes, Philip J; Berkun, Yackov; Schalm, Susanne; Murias, Sara; Dare, Jason A; Brown, Diane; Stone, Deborah L; Gao, Ling; Klausmeier, Thomas; Foell, Dirk; Jesus, Adriana A de; Chapelle, Dawn C; Kim, Hanna; Dill, Samantha; Colbert, Robert; Failla, Laura; Kost, Bahar; O'Brien, Michelle; Reynolds, James C; Folio, Les R; Calvo, Katherine R; Paul, Scott M; Weir, Nargues; Brofferio, Alessandra; Soldatos, Ariane; Biancotto, Angélique; Cowen, Edward W; Digiovanna, John G; Gadina, Massimo; Lipton, Andrew J; Hadigan, Colleen; Holland, Steven M; Fontana, Joseph; Alawad, Ahmad S; Brown, Rebecca J; Rother, Kristina I; Heller, Theo; Brooks, Kristina M; Kumar, Parag; Brooks, Stephen R; Waldman, Meryl; Singh, Harsharan K; Nickeleit, Volker; Silk, Maria; Prakash, Apurva; Janes, Jonathan M; Ozen, Seza; Wakim, Paul G; Brogan, Paul A; Macias, William L; Goldbach-Mansky, Raphaela

2018-04-12

Monogenic Interferon (IFN)-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN-response-gene-signature (IRS), inflammatory organ damage and high mortality. We used the janus kinase (JAK) inhibitor baricitinib with IFN-blocking activity in vitro, to ameliorate disease. Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 with SAVI (Stimulator of IFN genes (STING)-associated vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an Expanded Access Program. Patients underwent dose-escalation, benefit was assessed by reductions in daily disease symptoms and corticosteroid requirement. Quality-of-life, organ inflammation, changes in IFN-induced biomarkers, and safety were longitudinally assessed. 18 patients were treated for a mean duration of 3.0 years (1.5-4.9 years). The median daily symptom score decreased from 1.3 (IQR 0.93-1.78) to 0.25 (IQR 0.1-0.63) (P Eli Lilly. Eli Lilly is the sponsor of the compassionate use program.

Aims and methods of education: A recapitulation

Directory of Open Access Journals (Sweden)

Pantić Nataša

2007-01-01

Full Text Available This paper gives an overview of principal distinction between the aims of the so-called "traditional" and "progressive" education and respective pedagogies associated with each. The term "traditional" education is used to denote the kind of education that prepares people for their role in society as it is, while the term "progressive" is used for education that aspires to equip mankind with capacity to shape the change of society. The paper raises some critical questions about the role of pedagogy in achieving the aims of the progressive model, arguing that the employment of "progressive" methods does not necessarily guarantee the achievement of the commonly professed purposes of progressive education. This is illustrated in the paper by the results of a study in English schools showing how despite the claim of progressive methods, teachers tend to retain traditional attitudes and on the other hand, how even traditional teaching methods can serve the progressive purpose. This is not to advocate for the traditional pedagogy, but to suggest that it might be something other than pedagogy that makes a critical difference in educating liberal-minded citizens of the future. In this sense the paper explores the role of other factors that make a difference towards progressive education, such as democratization of human relations in school ethos and respect for children's freedom.

Use of Probiotic Microorganisms for Bio-Protective Aims

Directory of Open Access Journals (Sweden)

Filiz YANGILAR

2015-03-01

Full Text Available It was known that some diseases can be treated as the result of the use of antibiotics in certain periods and at certain dosages while inactivating and deteriorating normal microorganisms performing useful activities in human metabolism (in especially intestinal flora. It was occured that after the use of antibiotics, some defects can be seen resulting from antibiotics (such as allergy, diarrhea, gas formation etc. With this aim, nutraceutics and functional food have gained importance over the last years and consumers began to be interested in probiotics, natural antioxidants, dietary fibres, products with low calorie and cholesterol contents, especially the products containing probioticbacteria. Bacteriocins produced by probiotic bacteria can play important roles as food protective and safeguarding since they can compete with unwanted or pathogen microorganisms survive in the media and colonize in intestines. In this review, is aimed to emphasis bioprotective compounds, advantages and disadvantages of biopreservation method and the importance of the mechanisms of probiotic microorganisms.

Aims and methods of nuclear materials management

International Nuclear Information System (INIS)

Leven, D.; Schier, H.

1979-05-01

Whilst international safeguarding of fissile materials against abuse has been the subject of extensive debate, little public attention has so far been devoted to the internal security of these materials. All countries using nuclear energy for peaceful purposes have laid down appropriate regulations. In the Federal Republic of Germany safeguards are required, for instance, by the Atomic Energy Act, and are therefore a prerequisite for licensing. The aims and methods of national nuclear materials management are contrasted with viewpoints on international safeguards

Dissociated effects of distractors on saccades and manual aiming.

Science.gov (United States)

McIntosh, Robert D; Buonocore, Antimo

2012-08-01

The remote distractor effect (RDE) is a robust phenomenon whereby target-directed saccades are delayed by the appearance of a distractor. This effect persists even when the target location is perfectly predictable. The RDE has been studied extensively in the oculomotor domain but it is unknown whether it generalises to other spatially oriented responses. In three experiments, we tested whether the RDE generalises to manual aiming. Experiment 1 required participants to move their hand or eyes to predictable targets presented alone or accompanied by a distractor in the opposite hemifield. The RDE was observed for the eyes but not for the hand. Experiment 2 replicated this dissociation in a more naturalistic task in which eye movements were not constrained during manual aiming. Experiment 3 confirmed the lack of manual RDE across a wider range of distractor delays (0, 50, 100, and 150 ms). Our data imply that the RDE is specific to the oculomotor system, at least for non-foveal distractors. We suggest that the oculomotor RDE reflects competitive interactions between target and distractor representations in the superior colliculus, which are not necessarily shared by manual aiming.

77 FR 28761 - Mother's Day, 2012

Science.gov (United States)

2012-05-16

... House Council on Women and Girls as one of my first acts in office--to ensure we integrate the needs of women and girls into every decision we make. I was proud to sign the Lilly Ledbetter Fair Pay Act, which continues to help women secure equal pay for equal work, and my Administration continues to promote...

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International Development Research Centre (IDRC) Digital Library (Canada)

Transition et amélioration des indices mondiaux de philanthropie. Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana. Projet.

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International Development Research Centre (IDRC) Digital Library (Canada)

Transition et amélioration des indices mondiaux de philanthropie. Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana. Projet.

Résultats de recherche | Page 23 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Transition et amélioration des indices mondiaux de philanthropie. Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana. Projet ...

Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes

DEFF Research Database (Denmark)

Jimenez-Solem, Espen; Rasmussen, Mette H; Christensen, Mikkel

2010-01-01

Dulaglutide (LY-2189265) is a novel, long-acting glucagon-like peptide 1 (GLP-1) analog being developed by Eli Lilly for the treatment of type 2 diabetes mellitus (T2DM). Dulaglutide consists of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4, thereby protecting the GLP-1 moiety from...

Automated Instrumentation, Monitoring and Visualization of PVM Programs Using AIMS

Science.gov (United States)

Mehra, Pankaj; VanVoorst, Brian; Yan, Jerry; Lum, Henry, Jr. (Technical Monitor)

1994-01-01

We present views and analysis of the execution of several PVM (Parallel Virtual Machine) codes for Computational Fluid Dynamics on a networks of Sparcstations, including: (1) NAS Parallel Benchmarks CG and MG; (2) a multi-partitioning algorithm for NAS Parallel Benchmark SP; and (3) an overset grid flowsolver. These views and analysis were obtained using our Automated Instrumentation and Monitoring System (AIMS) version 3.0, a toolkit for debugging the performance of PVM programs. We will describe the architecture, operation and application of AIMS. The AIMS toolkit contains: (1) Xinstrument, which can automatically instrument various computational and communication constructs in message-passing parallel programs; (2) Monitor, a library of runtime trace-collection routines; (3) VK (Visual Kernel), an execution-animation tool with source-code clickback; and (4) Tally, a tool for statistical analysis of execution profiles. Currently, Xinstrument can handle C and Fortran 77 programs using PVM 3.2.x; Monitor has been implemented and tested on Sun 4 systems running SunOS 4.1.2; and VK uses XIIR5 and Motif 1.2. Data and views obtained using AIMS clearly illustrate several characteristic features of executing parallel programs on networked workstations: (1) the impact of long message latencies; (2) the impact of multiprogramming overheads and associated load imbalance; (3) cache and virtual-memory effects; and (4) significant skews between workstation clocks. Interestingly, AIMS can compensate for constant skew (zero drift) by calibrating the skew between a parent and its spawned children. In addition, AIMS' skew-compensation algorithm can adjust timestamps in a way that eliminates physically impossible communications (e.g., messages going backwards in time). Our current efforts are directed toward creating new views to explain the observed performance of PVM programs. Some of the features planned for the near future include: (1) ConfigView, showing the physical topology

Student Aims Performance in a Predominately Hispanic District

Science.gov (United States)

Chebultz, Lance

2012-01-01

School districts in the United States have undergone large changes over the last decade to accommodate No Child Left Behind (NCLB). Arizona accommodated NCLB through Arizona's Instrument to Measure Standards (AIMS). Expectations were established for all students, varying by group of students based on grade, special education status, free/reduced…

Research methodology the aims, practices and ethics of science

CERN Document Server

Pruzan, Peter

2016-01-01

This book is an in-depth guide to effective scientific research. Ranging from the philosophical to the practical, it explains at the outset what science can – and can’t – achieve, and discusses its relationship to mathematics and laws. The author then pays extensive attention to the scientific method, including experimental design, verification, uncertainty and statistics. A major aim of the book is to help young scientists reflect upon the deeper aims of their work and make the best use of their talents in contributing to progress. To this end, it also includes sections on planning research, on presenting one’s findings in writing, as well as on ethics and the responsibilities of scientists. .

The aim of psychoanalysis in theory and in practice.

Science.gov (United States)

Steiner, J

1996-12-01

The aims of psychoanalysis are reviewed in terms of theories of mental function and structure. The theory of mental conflict remains the central theory of classical psychoanalysis but has been deepened and supplemented by newer theories. In particular the theory of projective identification has radically altered our view of mental structure and function and has allowed us to reformulate the aims of psychoanalysis in terms of the re-acquisition and re-integration of projected parts of the self. The central role of mourning in this process is discussed, and some of the obstacles to progress are reviewed. It is suggested that oedipal resentments may play a central role in the creation of impasse.

Rifkin takes aim at USDA animal research.

Science.gov (United States)

Fox, Jeffrey L

1984-10-19

Jeremy Rifkin has filed a lawsuit to block U.S. Department of Agriculture (USDA) experiments involving the transfer of human growth hormone genes into sheep and pigs, which he rejects on environmental, economic, and ethical grounds. His real target is the Department's animal breeding program; his ultimate aim is "to establish the principle that there should be no crossing of species barriers in animals." USDA officials have not yet responded to the lawsuit but they intend to continue the experiments, which they consider crucial to the progress of research, until told to stop.

Investigation of relationships between AIMS shape properties and VST friction values.

Science.gov (United States)

2015-02-01

A thorough analysis was conducted for AIMS shape properties measured for virgin aggregates, aggregates : polished in the Micro-Deval (MD) for 105 and 210 minutes, and VST friction samples. Excellent repeatability of : AIMS angularity and texture meas...

Philosophy as Inquiry Aimed at the Absolute Knowledge

Directory of Open Access Journals (Sweden)

Ekaterina Snarskaya

2017-09-01

Full Text Available Philosophy as the absolute knowledge has been studied from two different but closely related approaches: historical and logical. The first approach exposes four main stages in the history of European metaphysics that marked out types of “philosophical absolutism”: the evolution of philosophy brought to light metaphysics of being, method, morals and logic. All of them are associated with the names of Aristotle, Bacon/Descartes, Kant and Hegel. Then these forms are considered in the second approach that defined them as subject-matter of philosophy as such. Due to their overall, comprehensive character, the focus of philosophy on them justifies its claim on absoluteness as far as philosophy is aimed at comprehension of the world’s unity regardless of the philosopher’s background, values and other preferences. And that is its prerogative since no other form of consciousness lays down this kind of aim. Thus, philosophy is defined as an everlasting attempt to succeed in conceiving the world in all its multifold manifestations. This article is to try to clarify the claim of philosophy on the absolute knowledge.

Student Teachers’ Attitude towards Twitter for Educational Aims

Directory of Open Access Journals (Sweden)

Victoria I. Marín

2014-07-01

Full Text Available This paper presents an educational experience with 100 student teachers from different courses of the University of the Balearic Islands (Spain in which Twitter is used for various different activities. The aim of this experiment was to explore student teachers’ perceptions in order to value their attitude towards Twitter for educational aims. Afterwards, students were asked to write down their reflections on an eportfolio. Data was collected from their eportfolio evidence, which was analysed to review their attitude towards the use of Twitter for educational purposes and for their future teaching and professional development. The conclusions indicate the need to conduct different educational activities in which Twitter is used in various ways. In addition, conclusions reflect on the real impact of Twitter on students’ learning enhancement, in order to improve student teachers’ attitudes towards social media in education. Therefore, this article contributes to the body of existing research on the use of technology in education, specifically to the possibilities of the use of social media and microblogging in Teacher Education.

International Fund of Aral Sea rescue:prospects and new aims

International Nuclear Information System (INIS)

Aslov, S.M.

2003-01-01

In this chapter of book author suggest about aims and prospects of International Fund of Aral Sea rescue. The base aim of International Fund of Aral Sea rescue was the funds attraction of Central Asia governments and international community-donors for financing of Program of Aral Sea basin. Now the Executive Committee of International Fund of Aral Sea rescue develops the program of basin of Aral Sea for the period till 2010

Treatment-completion rates with olanzapine long-acting injection versus risperidone long-acting injection in a 12-month, open-label treatment of schizophrenia: indirect, exploratory comparisons

Directory of Open Access Journals (Sweden)

Ascher-Svanum H

2012-05-01

Full Text Available Haya Ascher-Svanum1, William S Montgomery2, David P McDonnell3, Kristina A Coleman4, Peter D Feldman11Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 2Eli Lilly Australia Pty Ltd, West Ryde, New South Wales, Australia; 3Eli Lilly and Company, Cork, Ireland; 4OptumInsight, Lilyfield, New South Wales, AustraliaBackground: Little is known about the comparative effectiveness of atypical antipsychotics in long-acting injection formulation. Due to the absence of head-to-head studies comparing olanzapine long-acting injection and risperidone long-acting injection, this study was intended to make exploratory, indirect, cross-study comparisons between the long-acting formulations of these two atypical antipsychotics in their effectiveness in treating patients with schizophrenia.Methods: Indirect, cross-study comparisons between olanzapine long-acting injection and risperidone long-acting injection used 12-month treatment-completion rates, because discontinuation of an antipsychotic for any cause is a recognized proxy measure of the medication's effectiveness in treating schizophrenia. Following a systematic review of the literature, two indirect comparisons were conducted using open-label, single-cohort studies in which subjects were stabilized on an antipsychotic medication before depot initiation. The first analysis compared olanzapine long-acting injection (one study with pooled data from nine identified risperidone long-acting injection studies. The second analysis was a “sensitivity analysis,” using only the most similar studies, one for olanzapine long-acting injection and one for risperidone long-acting injection, which shared near-identical study designs and involved study cohorts with near-identical patient characteristics. Pearson Chi-square tests assessed group differences on treatment-completion rates.Results: Comparison of olanzapine long-acting injection data (931 patients with the pooled data from the nine

Predictors of remission in the treatment of major depressive disorder: real-world evidence from a 6-month prospective observational study

Directory of Open Access Journals (Sweden)

Novick D

2015-01-01

Full Text Available Diego Novick,1 Jihyung Hong,1 William Montgomery,2 Héctor Dueñas,3 Magdy Gado,4 Josep Maria Haro5 1Eli Lilly and Company, Windlesham, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, Australia; 3Eli Lilly de Mexico, Mexico City, Mexico; 4Eli Lilly and Company, Riyadh, Saudi Arabia; 5Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain Background: This study examined potential predictors of remission among patients treated for major depressive disorder (MDD in a naturalistic clinical setting, mostly in the Middle East, East Asia, and Mexico. Methods: Data for this post hoc analysis were taken from a 6-month prospective, noninterventional, observational study that involved 1,549 MDD patients without sexual dysfunction at baseline in 12 countries worldwide. Depression severity was measured using the Clinical Global Impression of Severity and the 16-item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16. Depression-related pain was measured using the pain-related items of the Somatic Symptom Inventory. Remission was defined as a QIDS-SR16 score ≤5. Generalized estimating equation regression models were used to examine baseline factors associated with remission during follow-up. Results: Being from East Asia (odds ratio [OR] 0.48 versus Mexico; P<0.001, a higher level of depression severity at baseline (OR 0.77, P=0.003, for Clinical Global Impression of Severity; OR 0.92, P<0.001, for QIDS-SR16, more previous MDD episodes (OR 0.92, P=0.007, previous treatments/therapies for depression (OR 0.78, P=0.030, and having any significant psychiatric and medical comorbidity at baseline (OR 0.60, P<0.001 were negatively associated with remission, whereas being male (OR 1.29, P=0.026 and treatment with duloxetine (OR 2.38 versus selective serotonin reuptake inhibitors, P<0.001 were positively associated with remission. However, the association between Somatic Symptom Inventory pain scores

ACA and the Triple Aim: Musings of a Health Care Actuary.

Science.gov (United States)

McCarthy, Mac

2015-01-01

In 2008, the Institute for Healthcare Improvement (IHI) promulgated the Triple Aim, which advocates simultaneous improvements in patient experiences, improved population health and lower cost per capita. In 2010, the Patient Protection and Affordable Care Act (ACA) promised quality, affordable health care for all Americans. It's fair to assume that the framers of ACA were aware of the Triple Aim, and it is likely that much of ACA was heavily influenced by IHI's positions. So it is reasonable, from time to time, to assess ACA's impact on health care against the Triple Aim principles.

Uncertainty in aiming movements and its association to hand function

Directory of Open Access Journals (Sweden)

Flávia Priscila de Paiva Silva

2015-09-01

Full Text Available AbstractThe purpose of this study was to analyze the influence of the uncertainty of target location on the planning and execution of aiming movements performed towards the ipsilateral and contralateral directions by the right and left upper limbs. In addition, the association between the performance of aiming movements and the performance of functional manual tasks was investigated. Two tasks were proposed: with prior knowledge of the movement direction (simple reaction time or not (choice reaction time. The grip strength and manual dexterity were measured. The choice option in response (i.e. uncertainty influenced planning of the aiming movements, but not its execution, while movements performed towards the contralateral direction were worse in execution as compared to the ipsilateral direction. Manual dexterity was significantly correlated with reaction times, while the performance during movement execution was significantly correlated with handgrip/pinch strength.

Advanced Industrial Materials (AIM) Program annual progress report, FY 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-05-01

The Advanced Industrial Materials (AIM) Program is a part of the Office of Industrial Technologies (OIT), Energy Efficiency and Renewable Energy, US Department of Energy (DOE). The mission of AIM is to support development and commercialization of new or improved materials to improve energy efficiency, productivity, product quality, and reduced waste in the major process industries. OIT has embarked on a fundamentally new way of working with industries--the Industries of the Future (IOF) strategy--concentrating on the major process industries that consume about 90% of the energy and generate about 90% of the waste in the industrial sector. These are the aluminum, chemical, forest products, glass, metalcasting, and steel industries. OIT has encouraged and assisted these industries in developing visions of what they will be like 20 or 30 years into the future, defining the drivers, technology needs, and barriers to realization of their visions. These visions provide a framework for development of technology roadmaps and implementation plans, some of which have been completed. The AIM Program supports IOF by conducting research and development on materials to solve problems identified in the roadmaps. This is done by National Laboratory/industry/university teams with the facilities and expertise needed to develop new and improved materials. Each project in the AIM Program has active industrial participation and support.

Program for accident and incident management support, AIMS

International Nuclear Information System (INIS)

Putra, M.A.

1993-12-01

A prototype of an advisory computer program is presented which could be used in monitoring and analyzing an ongoing incident in a nuclear power plant. The advisory computer program, called the Accident and Incident Management Support (AIMS), focuses on processing a set of data that is to be transmitted from a nuclear power plant to a national or regional emergency center during an incident. The AIMS program will assess the reactor conditions by processing the measured plant parameters. The applied model of the power plant contains a level of complexity that is comparable with the simplified plant model that the power plant operator uses. A standardized decay heat function and a steam water property library is used in the integral balance equations for mass and energy. A simulation of the station blackout accident of the Borssele plant is used to test the program. The program predicts successively: (1) the time of dryout of the steam generators, (2) the time of saturation of the primary system, and (3) the onset of core uncovery. The coolant system with the actual water levels will be displayed on the screen. (orig./HP)

Linking aims, paradigm and method in nursing research.

Science.gov (United States)

Houghton, Catherine; Hunter, Andrew; Meskell, Pauline

2012-01-01

To explore the use of paradigms as ontological and philosophical guides for conducting PhD research. A paradigm can help to bridge the aims of a study and the methods to achieve them. However, choosing a paradigm can be challenging for doctoral researchers: there can be ambiguity about which paradigm is suitable for a particular research question and there is a lack of guidance on how to shape the research process for a chosen paradigm. The authors discuss three paradigms used in PhD nursing research: post-positivism, interpretivism and pragmatism. They compare each paradigm in relation to its ontology, epistemology and methodology, and present three examples of PhD nursing research studies to illustrate how research can be conducted using these paradigms in the context of the research aims and methods. The commonalities and differences between the paradigms and their uses are highlighted. Creativity and flexibility are important when deciding on a paradigm. However, consistency and transparency are also needed to ensure the quality and rigour necessary for conducting nursing research. When choosing a suitable paradigm, the researcher should ensure that the ontology, epistemology and methodology of the paradigm are manifest in the methods and research strategies employed.

Worm Disease Profile of Primary School Children

Science.gov (United States)

Hartati; Destriani; Victoria, A. R.

2018-01-01

The result of an elementary study of relations between disease symptoms and signs with the wormy occurrence child at Elementary School in Ilir Barat II Subdistrict of Palembang in concerned in this research amount to 200 people from the population of 4200 people of a child in elementary school. The result indicates that the child roommates infested worm marked with a few symptoms like passion eat to Decrease the puking pain in the home of stomach after eating, diarrhea, defecate with the mucus and bleed the purities at the anus before controlled from some worm type of there no difference having a meaning between child roommates worm infested with the child roommates do not infest worm (P > 0.05). Symptom vomit got more amount by having a meaning a child by infested is Trichuris (RO > 2.669, P < 0/005). The result of infested Tricuris generate the more amount of symptoms lust to eat to Decrease by having a meaning of Compared to the which do not infest Trichuris (RO = 3.772; CI 95% = 1.214 to 11.726; P = 0.016) symptoms lust to eat to Decrease and more amount diarrhea got at Infest oxyuris with the special sign of purities at nighttime anus (RO = 0.557; 85% CI = 0.166 to 2.168). The risk of the happening of unfavorable nutrition According to BB / U and Also TB / U growing niche to more amount (having a meaning) at child roommates worm infested by a child Compared to the which do not infest worm.

Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc.

Directory of Open Access Journals (Sweden)

Toshihiro Kai

Full Text Available Owing to rapid and drastic changes in lifestyle and eating habits in modern society, obesity and obesity-associated diseases are among the most important public health problems. Hence, the development of therapeutic approaches to regulate obesity is strongly desired. In view of previous work showing that apoptosis inhibitor of macrophage (AIM blocks lipid storage in adipocytes, thereby preventing obesity caused by a high-fat diet, we here explored a strategy to augment circulating AIM levels. We synthesized the Fc portion of the soluble human immunoglobulin (IgM heavy chain and found that it formed a pentamer containing IgJ as natural IgM does, and effectively associated with AIM in vitro. When we injected the synthesized Fc intravenously into mice lacking circulating IgM, it associated with endogenous mouse AIM, protecting AIM from renal excretion and preserving the circulating AIM levels. As the synthesized Fc lacked the antigen-recognizing variable region, it provoked no undesired immune response. In addition, a challenge with the Fc-human AIM complex in wild-type mice, which exhibited normal levels of circulating IgM and AIM, successfully maintained the levels of the human AIM in mouse blood. We also observed that the human AIM was effectively incorporated into adipocytes in visceral fat tissue, suggesting its functionality against obesity. Thus, our findings reveal potent strategies to safely increase AIM levels, which could form the basis for developing novel therapies for obesity.

Patient Characteristics, Health Care Resource Utilization, and Costs Associated with Treatment-Regimen Failure with Biologics in the Treatment of Psoriasis.

Science.gov (United States)

Foster, Shonda A; Zhu, Baojin; Guo, Jiaying; Nikai, Enkeleida; Ojeh, Clement; Malatestinic, William; Goldblum, Orin; Kornberg, Lori J; Wu, Jashin J

2016-04-01

variance for continuous variables and chi-square tests for categorical variables without adjustment. Cost differences were compared using the propensity score-adjusted bin bootstrapping method. Overall, 2,146 patients met the enrollment criteria. The mean age was 45.1 years. Of these patients, 41.5% were considered treatment-regimen failures. Among treatment-regimen failures, 53% were females, and among non-treatment-regimen failures, 61% were male. Patients who experienced treatment-regimen failure had higher incidences of comorbid cerebrovascular disease, hypertension, chronic pulmonary disease, depression, and anxiety in the pre-index period and were more likely to use concomitant topicals (67.0% vs. 58.4%; P different characteristics and incurred higher all-cause health care costs than did patients without treatment-regimen failure during the pre-index period. This study was supported by Eli Lilly and Company. Foster, Zhu, Guo, Nikai, Malatestinic, Ojeh, and Goldblum are full-time employees and stockholders of Eli Lilly and Company. Kornberg is a full-time employee of INC Research, which was contracted by Eli Lilly to assist with medical writing. Wu has received research funding from AbbVie, Amgen, Coherus Biosciences, Eli Lilly, Janssen, Merck, Novartis, Pfizer, Regeneron, and Sandoz; he is a consultant for AbbVie, Amgen, Celgene, Dermira, DUSA Pharmaceuticals, Eli Lilly, and Pfizer. Study concept was developed by Foster, Ojeh, Malatestinic, and Goldblum. Zhu and Guo, along with Foster, took the lead in data collection, and data interpretation was performed by Nikai, Wu, and Foster, with assistance from the other authors. The manuscript was primarily written by Kornberg, along with Foster, with assistance from the other authors. All of the authors were involved with manuscript revision.

AIM analysis, synthetic, kinetic and mechanistic investigations of the ...

Indian Academy of Sciences (India)

analysis (NPA), atoms in molecules (AIM) methods and CHelpG keyword. ... obtained from studies of the effect of solvent, structure of reactions (different alkyl groups within the dialkyl ...... compounds) have provided useful evidence for steps 1.

Advanced Industrial Materials (AIM) Program: Annual progress report FY 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This Annual Report for FY 1995 contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Areas covered here are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

Man-boy lovers: assessment, counseling, and psychotherapy.

Science.gov (United States)

van Naerssen, A

1990-01-01

Clinical experiences with 36 males, between the ages of 21 and 60 are described. All of them felt an enduring sexual attraction for boys. Sixteen males were treated for sexual identity conflicts. For eight of them this ended in a positive self-labeling as pedophile, the others had severe problems with accepting sexuality as positive and lustful. Twenty males were treated for identity management problems and counseled how to handle their relationships with boys. Several modalities of interpersonal interaction in man-boy relationships are proposed and the ways conflicts can arise within these frames of reference are explored in counseling and psychotherapy.

Advanced Industrial Materials (AIM) program. Annual progress report. FY 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-04-01

The Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven `Vision Industries` that use about 80% of industrial energy and generated about 90% of industrial wastes. These are: aluminium; chemical; forest products; glass; metal casting; refineries; and steel. OIT is working with these industries, through appropriate organizations, to develop Visions of the desired condition of each industry some 20 or 25 years in the future and then to prepare Road Maps and Implementation Plans to enable them to reach their goals. The mission of AIM has, therefore, changed to `Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.` Though AIM remains essentially a National Laboratory Program, it is necessary that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains healthy and productive, thanks to the superb investigators and Laboratory Program Managers. Separate abstracts have been indexed into the energy database for articles from this report.

Plasma health care - Aims, constraints and progress

International Nuclear Information System (INIS)

Morfill, G.E.; Zimmerman, J.L.

2013-01-01

Health Care covers three areas of interest for cold atmospheric pressure plasmas: Cosmetics, Hygiene and Medicine. These areas can be subdivided into personal and professional care. In this review will concentrate on Hygiene and Medicine. In professional hygiene the most important plasma contribution is sterilization, decontamination and disinfection. The main aim is the prevention of diseases or their containment. Progress in the development of efficient bactericidal plasma sources has been rapid, so that it appears realistic to use plasmas to combat nosocomial infections as well as community associated infections in the not too distant future. The advantages of plasma devices – they use air and electricity only, there are no waste products, they are inexpensive to manufacture and operate, easy to transport and install, and bactericidal effects are fast (seconds). Plasmas can efficiently kill resistant bacteria (e.g. MRSA) and tests have shown no resistance build-up so far. With an estimated 2 Million hospital induced infections each year in the US alone, and about 100.000 resulting deaths, very efficient, safe and fast hospital plasma hygiene devices would appear to be a very important weapon to help contain the spread of infectious diseases. In Medicine there are a number of ambitious ideas and aims. Plasmas can be “designed” to some extent. They can include different active species that can have an effect at the cellular level. There are ionic atoms and molecules, whose medical use need to be evaluated – the vision is that a new area of “plasma pharmacy” could develop. First steps are currently being taken in biological studies. Also the excited atoms in cold atmospheric plasmas may make cell walls more permeable for such species. (author)

The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation model.

Science.gov (United States)

Mongkolwat, Pattanasak; Kleper, Vladimir; Talbot, Skip; Rubin, Daniel

2014-12-01

Knowledge contained within in vivo imaging annotated by human experts or computer programs is typically stored as unstructured text and separated from other associated information. The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation information model is an evolution of the National Institute of Health's (NIH) National Cancer Institute's (NCI) Cancer Bioinformatics Grid (caBIG®) AIM model. The model applies to various image types created by various techniques and disciplines. It has evolved in response to the feedback and changing demands from the imaging community at NCI. The foundation model serves as a base for other imaging disciplines that want to extend the type of information the model collects. The model captures physical entities and their characteristics, imaging observation entities and their characteristics, markups (two- and three-dimensional), AIM statements, calculations, image source, inferences, annotation role, task context or workflow, audit trail, AIM creator details, equipment used to create AIM instances, subject demographics, and adjudication observations. An AIM instance can be stored as a Digital Imaging and Communications in Medicine (DICOM) structured reporting (SR) object or Extensible Markup Language (XML) document for further processing and analysis. An AIM instance consists of one or more annotations and associated markups of a single finding along with other ancillary information in the AIM model. An annotation describes information about the meaning of pixel data in an image. A markup is a graphical drawing placed on the image that depicts a region of interest. This paper describes fundamental AIM concepts and how to use and extend AIM for various imaging disciplines.

Qualitative approaches to use of the RE-AIM framework: rationale and methods.

Science.gov (United States)

Holtrop, Jodi Summers; Rabin, Borsika A; Glasgow, Russell E

2018-03-13

There have been over 430 publications using the RE-AIM model for planning and evaluation of health programs and policies, as well as numerous applications of the model in grant proposals and national programs. Full use of the model includes use of qualitative methods to understand why and how results were obtained on different RE-AIM dimensions, however, recent reviews have revealed that qualitative methods have been used infrequently. Having quantitative and qualitative methods and results iteratively inform each other should enhance understanding and lessons learned. Because there have been few published examples of qualitative approaches and methods using RE-AIM for planning or assessment and no guidance on how qualitative approaches can inform these processes, we provide guidance on qualitative methods to address the RE-AIM model and its various dimensions. The intended audience is researchers interested in applying RE-AIM or similar implementation models, but the methods discussed should also be relevant to those in community or clinical settings. We present directions for, examples of, and guidance on how qualitative methods can be used to address each of the five RE-AIM dimensions. Formative qualitative methods can be helpful in planning interventions and designing for dissemination. Summative qualitative methods are useful when used in an iterative, mixed methods approach for understanding how and why different patterns of results occur. In summary, qualitative and mixed methods approaches to RE-AIM help understand complex situations and results, why and how outcomes were obtained, and contextual factors not easily assessed using quantitative measures.

Continuous flow technology vs. the batch-by-batch approach to produce pharmaceutical compounds.

Science.gov (United States)

Cole, Kevin P; Johnson, Martin D

2018-01-01

For the manufacture of small molecule drugs, many pharmaceutical innovator companies have recently invested in continuous processing, which can offer significant technical and economic advantages over traditional batch methodology. This Expert Review will describe the reasons for this interest as well as many considerations and challenges that exist today concerning continuous manufacturing. Areas covered: Continuous processing is defined and many reasons for its adoption are described. The current state of continuous drug substance manufacturing within the pharmaceutical industry is summarized. Current key challenges to implementation of continuous manufacturing are highlighted, and an outlook provided regarding the prospects for continuous within the industry. Expert commentary: Continuous processing at Lilly has been a journey that started with the need for increased safety and capability. Over twelve years the original small, dedicated group has grown to more than 100 Lilly employees in discovery, development, quality, manufacturing, and regulatory designing in continuous drug substance processing. Recently we have focused on linked continuous unit operations for the purpose of all-at-once pharmaceutical manufacturing, but the technical and business drivers that existed in the very beginning for stand-alone continuous unit operations in hybrid processes have persisted, which merits investment in both approaches.

Action Information Management System (AIMS): a User's View

Science.gov (United States)

Wiskerchen, M.

1984-01-01

The initial approach used in establishing a user-defined information system to fulfill the needs of users at NASA Headquarters was unsuccessful in bringing this pilot endeaveor to full project status. The persistence of several users and the full involvement of the Ames Research Center were the ingredients needed to make the AIMS project a success. The lesson learned from this effort is that NASA should always work from its organizational strengths as a Headquarters-Center partnership.

[Aiming for zero blindness].

Science.gov (United States)

Nakazawa, Toru

2015-03-01

-independent factors, as well as our investigation of ways to improve the clinical evaluation of the disease. Our research was prompted by the multifactorial nature of glaucoma. There is a high degree of variability in the pattern and speed of the progression of visual field defects in individual patients, presenting a major obstacle for successful clinical trials. To overcome this, we classified the eyes of glaucoma patients into 4 types, corresponding to the 4 patterns of glaucomatous optic nerve head morphology described: by Nicolela et al. and then tested the validity of this method by assessing the uniformity of clinical features in each group. We found that in normal tension glaucoma (NTG) eyes, each disc morphology group had a characteristic location in which the loss of circumpapillary retinal nerve fiber layer thickness (cpRNFLT; measured with optical coherence tomography: OCT) was most likely to occur. Furthermore, the incidence of reductions in visual acuity differed between the groups, as did the speed of visual field loss, the distribution of defective visual field test points, and the location of test points that were most susceptible to progressive damage, measured by Humphrey static perimetry. These results indicate that Nicolela's method of classifying eyes with glaucoma was able to overcome the difficulties caused by the diverse nature of the disease, at least to a certain extent. Building on these findings, we then set out to identify sectors of the visual field that correspond to the distribution of retinal nerve fibers, with the aim of detecting glaucoma progression with improved sensitivity. We first mapped the statistical correlation between visual field test points and cpRNFLT in each temporal clock-hour sector (from 6 to 12 o'clock), using OCT data from NTG patients. The resulting series of maps allowed us to identify areas containing visual field test points that were prone to be affected together as a group. We also used a similar method to identify visual

Using the RE-AIM Framework to Evaluate Disaster Recovery Videos

Directory of Open Access Journals (Sweden)

Sarah Cronin

2018-02-01

Full Text Available Natural disasters both increase and cause financial challenges for survivors. Crisis support reduces negative outcomes such as financial stress, yet survivors are often unaware or unable to access available services. Aiming to innovatively improve access to quality financial education and to support financial recovery post-disaster, a video series was developed with a community advisory board. The RE-AIM framework informed a developmental evaluation measuring the videos’ influence. Results indicated majority of participants have used or intend to use the videos in their disaster work. This indicates the video series may be a helpful tool for disaster responders when providing financial recovery support.

Refractive aim and visual outcome after phacoemulsification: A 2 ...

African Journals Online (AJOL)

2016-03-24

Mar 24, 2016 ... was met, 21 eyes (14.3%) did not meet their refractive aim, 20 eyes (12.7%) were ... countries, where blindness is associated with considerable ... and better, the total range of refractive errors postoperatively ... required intraocular lenses (IOL), medical record efficiency, ..... problem that can be alleviated.

Armed To Learn: Aiming At California K 12 School Gun Policy

Science.gov (United States)

2016-03-01

AIMING AT CALIFORNIA K-12 SCHOOL GUN POLICY by Catherine Wilson Jones March 2016 Thesis Co-Advisors: Kathleen Kiernan John Rollins...Master’s thesis 4. TITLE AND SUBTITLE ARMED TO LEARN: AIMING AT CALIFORNIA K-12 SCHOOL GUN POLICY 5. FUNDING NUMBERS 6. AUTHOR(S) Catherine...gap in viewpoints between gun control advocates who want tighter gun control and constitutionalists who believe as strongly in the Second Amendment

Super Hydrides.

Science.gov (United States)

1988-03-01

enantioselective synthesis Of the clinically important anti-depressants, (-)Tomoxetine, Fluoxetine (Prozac, Eli Lilly), and Nisoxetine (Scheme 1). Schem I a I...decade or so asymmetric synthesis has emerged from the cold to vie quite successfully with enzymes as a means of incorporating chirality in...with Chiral Alkoxyborohydrides. We have extended our synthesis of potassium dialkoxyborohydrides, K+IRB(OR’) 21- , conveniently prepared by the addition

Ensaios terapêuticos com penicilina: III - Bouba (Framboesia, pian, yaws: (continuação: penicilina de procedência americana, empregada em doses baixas também cura aparentemente esta enfermidade

Directory of Open Access Journals (Sweden)

A. M. da Cunha

1944-10-01

Full Text Available Five patients of yaws were treated with american Penicillin (Squibb, Winthrop and Lilly, in small dosis. The treatment has been performed, using 200 Oxford units each 4 hours. The total amount of units "per" subject, has varied from 24.000 to 54.000. A complete disappearence of the external lesions was obtained between the 12th and the 25th day of treatment.

Molecular Mechanisms and Treatment Strategies for Obesity-Associated Coronary Artery Disease, an Imminent Military Epidemic

Science.gov (United States)

2007-12-01

in response to another ‘hit.’ This two-hit model of UPR-induced apoptosis is critical to understanding how FC enrichment kills macrophages. In this...Schering- Plough Research Grant, 1989-1995, Responsible Investigator, $50,000 per annum Individual National Research Supplement Award for Postdoctoral...Association grant-in-aid study section (1994) Consultant for Merck, Schering- Plough , Warner-Lambert, Berlex, Eli Lilly, Pfizer, Talaria Biotech, ReddyUS

Context and Domain Knowledge Enhanced Entity Spotting in Informal Text

Science.gov (United States)

Gruhl, Daniel; Nagarajan, Meena; Pieper, Jan; Robson, Christine; Sheth, Amit

This paper explores the application of restricted relationship graphs (RDF) and statistical NLP techniques to improve named entity annotation in challenging Informal English domains. We validate our approach using on-line forums discussing popular music. Named entity annotation is particularly difficult in this domain because it is characterized by a large number of ambiguous entities, such as the Madonna album "Music" or Lilly Allen's pop hit "Smile".

Inimeste teadlikkus arendab ravimiturgu / Rauno Pukonen ; ref. Enn Tosso

Index Scriptorium Estoniae

Pukonen, Rauno

2003-01-01

Ilmunud ka: Delovõje Vedomosti 15. okt. lk. 14. Eli Lilly juhatuse esimehe Rauno Pukoneni ettekandest Äripäeva konverentsil Äriplaan 2004. Ettekandja sõnul on Eesti ravimiturg ebaatraktiivne ja ettearvamatu, kompenseeritavate ravimite valik on kesine, Eesti tarbija jääb väga paljudest ravimitest ilma. Kommenteerib AS-i Magnum Medical juhatuse liige Tarmo Laanetu. Vt. samas: Ravimiturg riigi lõa otsas. Diagramm

FLT-PET/CT as a Biomarker of Therapeutic Response in Pemetrexed Therapy for Non-Small Cell Lung Cancer

Science.gov (United States)

2016-12-01

Teva Pharmaceuticals , Petach Tikva Israel) were provided freshly prepared as a 1mg/ml sterile saline solution by the Abramson Cancer Center...human and murine, pemetrexed (ALIMTA; Eli Lilly and Company, Indianapolis, IN) and cisplatin (Teva Pharmaceuticals , PetachTikva Israel) were provided...Griffiths JR, Doblas S, Sinkus R, Laverman P, Oyen WJ, Heerschap A, Boerman OC. Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI

A review of the efficacy of atomoxetine in the treatment of attention-deficit hyperactivity disorder in children and adult patients with common comorbidities

Directory of Open Access Journals (Sweden)

Clemow DB

2017-02-01

Full Text Available David B Clemow,1 Chris Bushe,2 Michele Mancini,3 Michael H Ossipov,4 Himanshu Upadhyaya1 1Eli Lilly and Company, Indianapolis, IN, USA; 2Eli Lilly, Windlesham, UK; 3Eli Lilly Italia S.p.A., Sesto Fiorentino, Italy; 4inVentiv Health Clinical, LLC, Blue Bell, PA, USA Abstract: Attention-deficit hyperactivity disorder (ADHD is a common neuropsychiatric disorder that is often diagnosed during childhood, but has also increasingly been recognized to occur in adults. Importantly, up to 52% of children (including adolescents and 87% of adults with ADHD also have a comorbid psychiatric disorder. The presence of a comorbid disorder has the potential to impact diagnosis and could affect treatment outcomes. Atomoxetine is a nonstimulant treatment for ADHD. Despite numerous published studies regarding efficacy of atomoxetine in the treatment of ADHD in patients with comorbid disorders, there is limited information about the impact of individual common comorbid disorders on the efficacy of atomoxetine for ADHD, especially with regard to adults. Moreover, a cumulative review and assessment of these studies has not been conducted. For this reason, we performed a literature review to find, identify, and cumulatively review clinical studies that examined the efficacy of atomoxetine in the treatment of patients with ADHD and comorbid psychiatric disorders. We found a total of 50 clinical studies (37 in children; 13 in adults that examined the efficacy of atomoxetine in patients with ADHD and a comorbid disorder. The comorbidities that were studied in children or in adults included anxiety, depression, and substance use disorder. Overall, the presence of comorbidity did not adversely impact the efficacy of atomoxetine in treatment of ADHD symptoms in both patient populations. In the studies identified and assessed in this review, atomoxetine did not appear to exacerbate any of the comorbid conditions and could, therefore, be an important therapy choice for the

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

Directory of Open Access Journals (Sweden)

Liu L

2016-04-01

Full Text Available Ling Liu,1 Jirong Lu,1 Barrett W Allan,2 Ying Tang,2 Jonathan Tetreault,1 Chi-kin Chow,1 Barbra Barmettler,2 James Nelson,2 Holly Bina,1 Lihua Huang,3 Victor J Wroblewski,4 Kristine Kikly1 1Biotechnology Discovery Research, Indianapolis, IN, 2Applied Molecular Evolution, Lilly Biotechnology Center, San Diego, CA, 3Bioproduct Research and Development, 4Drug Disposition, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA Abstract: Interleukin (IL-17A exists as a homodimer (A/A or as a heterodimer (A/F with IL-17F. IL-17A is expressed by a subset of T-cells, called Th17 cells, at inflammatory sites. Most cell types can respond to the local production of IL-17A because of the near ubiquitous expression of IL-17A receptors, IL-17RA and IL-17RC. IL-17A stimulates the release of cytokines and chemokines designed to recruit and activate both neutrophils and memory T-cells to the site of injury or inflammation and maintain a proinflammatory state. IL-17A-producing pathogenic T-cells contribute to the pathogenesis of autoimmune diseases, including psoriasis, psoriatic arthritis, rheumatoid arthritis, and ankylosing spondylitis. This study describes the generation and characterization of ixekizumab, a humanized IgG4 variant IL-17A-neutralizing antibody. Ixekizumab binds human and cynomolgus monkey IL-17A with high affinity and binds rabbit IL-17A weakly but does not bind to rodent IL-17A or other IL-17 family members. Ixekizumab effectively inhibits the interaction between IL-17A and its receptor in binding assays and potently blocks IL-17A-induced GRO or KC secretion in cell-based assays. In an in vivo mouse pharmcodynamic model, ixekizumab blocks human IL-17A-induced mouse KC secretion. These data provide a comprehensive preclinical characterization of ixekizumab, for which the efficacy and safety have been demonstrated in human clinical trials in psoriasis and psoriatic arthritis.Keywords: ixekizumab, IL-17A monoclonal antibody

Sex differences in the course of schizophrenia across diverse regions of the world

Directory of Open Access Journals (Sweden)

Novick D

2016-11-01

Full Text Available Diego Novick,1 William Montgomery,2 Tamas Treuer,3 Maria Victoria Moneta,4 Josep Maria Haro4 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Eli Lilly and Company, Neuroscience Research, Budapest, Hungary; 4Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain Abstract: This study explores sex differences in the outcomes of patients with schizophrenia (clinical/functional remission and recovery across diverse regions of the world (Northern Europe, Southern Europe, Central and Eastern Europe, Latin America, East Asia, and North Africa and the Middle East. Data (n=16,380 for this post hoc analysis were taken from the World-Schizophrenia Health Outcomes Study. In most regions, females had a later age at first service contact for schizophrenia, a lower level of overall/negative symptom severity, lower rates of alcohol/substance abuse and paid employment, and higher percentages of having a spouse/partner and independent living. Overall, females had slightly higher rates of clinical remission (58.0% vs 51.8%, functional remission (22.8% vs 16.0%, and recovery (16.5% vs 16.0% at 36 months (P<0.001 for all. This pattern was consistently observed in Southern Europe and Northern Europe even after controlling for baseline sex differences, but not in other regions. In Central and Eastern Europe, rates of clinical remission were higher in females at 36 months, but those of functional remission and recovery were similar between males and females. The opposite was observed for Latin America. In East Asia, sex differences were rarely observed for these outcomes. Finally, in North Africa and the Middle East, sex differences in these outcomes were pronounced only in regression analyses. These regional variations shed light on the importance of psychosocial and cultural factors and their effects on sex in the prognosis of schizophrenia. Keywords: sex, remission, recovery

NASA tells physicists to aim for the stars

CERN Multimedia

MacIlwain, C

1999-01-01

Dan Goldin, administrator at NASA, suggested that the next generation of instruments for high-energy physics research should be built in space. This did not go down well at Fermilab where a case is being made for a new ground-based accelerator. Goldin's aim though was simply to tell the scientific community that NASA is prepared to spend big money on physics in space. NASA also wants to work more closely with the DOE and the NSF to support space-based experiments (1 page).

What's the Deal with Methane at LUST Spill Sites? Part 1

Science.gov (United States)

This article is specifically intended to discuss methane produced from releases of ethanol and gasoline-ethanol mixtures. There may be other sources of methane at a site, including leaks of natural gas or methane produced from the natural decay of buried plant tissues or from th...

Seeing love, or seeing lust: how people interpret ambiguous romantic situations

NARCIS (Netherlands)

Epstude, K.; Förster, J.

2011-01-01

Interpreting ambiguous situations is a task individuals face on a daily basis. In romantic contexts the accurate interpretation of these situations is of particular importance. In the present set of studies we investigated how level of construal guides individual perception in these cases. When a

Seeing love, or seeing lust : How people interpret ambiguous romantic situations

NARCIS (Netherlands)

Epstude, Kai; Foerster, Jens

Interpreting ambiguous situations is a task individuals face on a daily basis. In romantic contexts the accurate interpretation of these situations is of particular importance. In the present set of studies we investigated how level of construal guides individual perception in these cases. When a

Lust voor het oog. Over de schoonheid en goedheid van pornografie

NARCIS (Netherlands)

P.J.J. Delaere (Patrick)

2012-01-01

textabstractAbstract: Voor het idée reçue dat pornografische kunst een contradictie in de termen is wordt doorgaans het volgende argument in stelling gebracht: porno en kunst sluiten elkaar uit omdat ze met een verschillend doel worden vervaardigd en met een al even verschillend oogmerk worden

The pastoral implications of human freedom according to Juan Luis Segundo

Directory of Open Access Journals (Sweden)

Vicente de Paula Ferreira

2016-09-01

Full Text Available The paper aims to reflect the issue of human freedom based on the underlying principles of the Christian faith in a time of anthropological vulnerability, especially in Latin American. It holds that Christianity must insist on its proposal to promote universal goodwill, despite a human horizon marked by selfishness and lust for power and money. This approach presupposes a radical position of a listener of the divine mystery, revealed in Jesus Christ, as a way to fulfill the human condition. Theoretical framework: Liberation Theology, in the view of Juan Luis Segundo, and its well-established tradition of transforming realities of injustice through faith, comprises the core argument of this text. Findings: Christian salvation necessarily implies the kenosis (κένωσις of Jesus, i.e., Christ “emptied Himself” (Ph. 2:7, and through His humble dispossession, He broke with all closed systems of the world, and inaugurated a new venture of a liberated freedom: the agape of love. Conclusion: Christian praxis as daily care for the poorest and prophecy of forgiveness rescues the memory of the victims of all forms of human selfishness. 

El adulterio y la violencia femenina en algunos pliegos sueltos poéticos del siglo XVI

Directory of Open Access Journals (Sweden)

Sánchez-Pérez, María

2013-12-01

Full Text Available The aim of this article is to study the depiction of adultery and female violence in poetic chapbooks of the 16th century. By going over several cases we will show that adulterous women perform all kinds of atrocities and killings to enjoy her lover freely. Occasionally she will murder her husband, but also anyone who comes between their relationship. The image we get, then, is that of a lustful, cruel and dangerous woman, according to the mentality of the time.El objetivo de este trabajo es estudiar el tratamiento del adulterio y la violencia femenina en pliegos sueltos poéticos del siglo XVI. Mediante un recorrido por varios casos veremos cómo la mujer adúltera comete todo tipo de atrocidades y asesinatos para gozar libremente de su amante. En ocasiones asesinará al marido, pero también a todos aquellos que se interpongan en su relación. Se nos presenta así la imagen de una mujer libidinosa, cruel y peligrosa, de acuerdo con la concepción y la mentalidad de la época.

Giorno e Notte: le città di Babele

Directory of Open Access Journals (Sweden)

Daniela Adorni

2015-03-01

Full Text Available This paper aims to start a reflection on the double and ambiguous identity of the cities. On one side, the “public face” of labour towns, made by work, social organization and public relations. A face that is characterized by productive efficiency and the “politically correct”. On the other side, instead, the “dark face” of the cities represented by the various features of marginality and exclusion, of the borderline relations, sometimes close or beyond the borders of law. Night and day, that coexist and take turns, and marked the city life without a break. The reassuring pulse of the chaos of the working city, opposed to the night time of silence and solitude, of anxiety, revelation, and lust. Night and day that overlap, although they’re the result of the ambiguity of human being. A contradiction that unveils and conceals the soul and that produce ambiguous behaviours, not always accepted by the social rules. The authors try to direct a multitude of multidisciplinary suggestions into a historiographical path, obviously awake that – at the present state-of-art – we are just talking of a first temporary palimpsest.

IR technology for enhanced force protection by AIM

Science.gov (United States)

Breiter, R.; Ihle, T.; Rode, W.; Wendler, J.; Rühlich, I.; Haiml, M.; Ziegler, J.

2008-04-01

In all recent missions our forces are faced with various types of asymmetric threads like snipers, IEDs, RPGs or MANPADS. 2 nd and 3 rd Gen IR technology is a backbone of modern force protection by providing situational awareness and accurate target engagement at day/night. 3 rd Gen sensors are developed for thread warning capabilities by use of spectral or spatial information. The progress on a dual-color IR module is discussed in a separate paper [1]. A 1024x256 SWIR array with flexure bearing compressor and pulse tube cold finger provides > 50,000h lifetime for space or airborne hyperspectral imaging in pushbroom geometry with 256 spectral channels for improved change detection and remote sensing of IEDs or chemical agents. Similar concepts are pursued in the LWIR with either spectroscopic imaging or a system of LWIR FPA combined with a cooled tunable Laser to do spectroscopy with stimulated absorption of specific wavelengths. AIM introduced the RangIR sight to match the requirements of sniper teams, AGLs and weapon stations, extending the outstanding optronic performance of the fielded HuntIR with position data of a target by a laser range finder (LRF), a 3 axis digital magnetic compass (DMC) and a ballistic computer for accurate engagement of remote targets. A version with flexure bearing cooler with >30,000h life time is being developed for continuous operation in e.g. gunfire detection systems. This paper gives an overview of AIM's technologies for enhanced force protection.

An observational study of duloxetine versus SSRI monotherapy for the treatment of painful physical symptoms in Japanese patients with major depressive disorder: primary analysis

Directory of Open Access Journals (Sweden)

Kuga A

2017-08-01

Full Text Available Atsushi Kuga,1 Toshinaga Tsuji,2 Shinji Hayashi,2 Mako Matsubara,3 Shinji Fujikoshi,4 Hirofumi Tokuoka,1 Aki Yoshikawa,5 Rodrigo Escobar,6 Kazuhide Tanaka,7 Takaharu Azekawa8 1Bio Medicine, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2Medical Affairs Department, Shionogi & Co. Ltd, Osaka, Japan; 3Pharmacovigilance Department, Shionogi & Co. Ltd, Osaka, Japan; 4Statistical Science, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 5Scientific Communications, Medicines Development Unit Japan, Eli Lilly Japan K.K. Kobe, Japan; 6Bio-Medicines, Eli Lilly and Company, Indianapolis, IN, USA; 7Hitsuji Clinic, Kusatsu, Japan; 8Shioiri Mental Clinic, Yokosuka, Japan Objective: The objective of this study was to assess the effectiveness of duloxetine monotherapy, in comparison with selective serotonin reuptake inhibitor (SSRI monotherapy, in the treatment of painful physical symptoms (PPS in Japanese patients with major depressive disorder (MDD in real-world clinical settings.Methods: This was a multicenter, 12-week prospective, observational study. This study enrolled MDD patients with at least moderate PPS, defined as a Brief Pain Inventory-Short Form (BPI-SF average pain score (item 5 ≥3. Patients were treated with duloxetine or SSRIs (escitalopram, sertraline, paroxetine, or fluvoxamine for 12 weeks, and PPS were assessed by BPI-SF average pain score. The primary outcome was early improvement in the BPI-SF average pain score at 4 weeks post-baseline. Results: A total of 523 patients were evaluated for treatment effectiveness (duloxetine N=273, SSRIs N=250. The difference in BPI-SF average pain score between the two groups was not statistically significant at 4 weeks post-baseline, the primary endpoint (least-squares mean change from baseline [95% confidence interval]: duloxetine,−2.8 [−3.1, −2.6]; SSRIs, −2.5 [−2.8, −2.3]; P=0.166. There was a numerical advantage for duloxetine in improvement

Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia

Directory of Open Access Journals (Sweden)

Novick D

2016-02-01

Full Text Available Diego Novick,1 William Montgomery,2 Josep Maria Haro,3 Maria Victoria Moneta,3 Gang Zhu,4 Li Yue,5 Jihyung Hong,6 Héctor Dueñas,7 Roberto Brugnoli8 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 5Lilly Suzhou Pharmaceutical Company, Ltd, Shanghai, People’s Republic of China; 6Department of Healthcare Management, Gachon University, Seongnam, South Korea; 7Eli Lilly de Mexico, Mexico City, Mexico; 8School of Medicine, Sapienza University of Rome, Rome, ItalyPurpose: To assess and compare the levels of functioning in patients with major depressive disorder treated with either duloxetine with a daily dose of ≤60 mg or a selective serotonin reuptake inhibitor (SSRI as monotherapy for up to 6 months in a naturalistic setting in East Asia. In addition, this study examined the impact of painful physical symptoms (PPS on the effects of these treatments.Patients and methods: Data for this post hoc analysis were taken from a 6-month prospective observational study involving 1,549 patients with major depressive disorder without sexual dysfunction. The present analysis focused on a subgroup of patients from East Asia (n=587. Functioning was measured using the Sheehan Disability Scale (SDS. Depression severity was assessed using the 16-item Quick Inventory of Depressive Symptomatology-Self Report. PPS were rated using the modified Somatic Symptom Inventory. A mixed model with repeated measures was fitted to compare the levels of functioning between duloxetine-treated (n=227 and SSRI-treated (n=225 patients, adjusting for baseline patient characteristics.Results: The mean SDS total score was similar between the two treatment cohorts (15.46 [standard deviation =6.11] in the duloxetine

Effects of Economic Policies Aimed at Encouraging a Healthier Grain Consumption

OpenAIRE

Nordstrom, Jonas; Thunstrom, Linda

2007-01-01

In this paper, we evaluate the effects of policy reforms aimed at achieving two policy objectives for grain consumption; (a) to double the intake of bread and breakfast cereals and (b) to ensure that half of the bread and breakfast cereals consumed are whole grain products. The overall aim of these policy objectives are to increase the dietary fibre intake from grain consumption so as to significantly contribute to the general recommended (minimum) increase of the fibre intake. Based on param...

The orientation, principles, priorities and aims of the state environmental policy

International Nuclear Information System (INIS)

1998-01-01

This chapter contains: (A) The orientation and priorities of state environmental policy of the government of the Slovak Republic which were approved 18 November 1993 by the resolution No 339. On the basis of the Strategy, principles and priorities of state environmental policy 70 short-terminable aims up to 1996, next 59 middle-terminable of aims up to years 2000 - 2010 and 33 general and partial long-terminable aims up to 2030 and longer were formulated. The Strategy is determined by next 5 branches oriented priorities: (1) air protection before pollutants and the global environmental safety; (2) organization of sufficiency of drinking water and decreasing of pollution of other waters under permissible limits; (3) soil protection before degeneration and organization of non-defected food-stuffs and other wares; (4) minimization of formation, use and good waste liquidate; (5) preservation of bio-diversity, preservation and rational use of natural reserves and optimization of place structure and use of the country. (B) The principles and priorities of state environmental policy determinate implementation and observance of then principles of the state environmental policy. (C) Total 162 aims of the Strategy of the state environmental policy and next followed programs, projects and measures of the environmental policy of the Slovak Republic can be grouped into 4 blocks: (1) the environmental policy in the protection of air, water and before of risk factors, in the nuclear safety and waste economy (environmental safety; (2) the environmental policy in protection of the nature and the country, protection and use of mineral surroundings, soils and forest;; (3) the environmental policy in the economy; (4) the environmental policy in the guidance, education, public information, organization, control and coordination of the ministration on the environment. These aims are grouped into 10 sectors. (D) The government of the Slovak republic has first National environmental

Toxic Hazards Research Unit Annual Technical Report: 1984

Science.gov (United States)

1984-09-01

exposed to TOCP exhibited the classic lesions of delayed neuropathy (Smith and Lillie, 1931; Barnes and Denz, 1953; (avanagh, 1954; and Fenton , 1955...Safety of *.i Chemicals in Food, Drugs, and Cosmetics , The staff of the Divi- sion of Pharmacology of the Federal Food and Drug Administration, Austin...Annual Technical Report: 1967, AMRL-TR-67-137 (AD 834723), Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, Ohio. Fenton , J. C

Résultats de recherche | Page 10 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana. Projet. Réseau d'échanges et de recherche dans les deltas de l'océan Indien occidental. Le réseau ...

The Ncar East in the 21st Century

Directory of Open Access Journals (Sweden)

Wigand Ritter

2012-10-01

Full Text Available Although an "avalanche of people" may be expected in thenear future lillie confidence seems to be justified with respect toa peaceful and prosperous development in the Near East. Politicalantagonism, often fuelled by religious intolerance threatei!Sor even pre1·ents the evaluation of promising opportunities atthis huge area between the Old World continents which couldotlwwise benefit so much from the by-passing great world trafficroutes.

Résultats de recherche | Page 41 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cette subvention aide à transférer les activités d'élaboration des indices mondiaux de dons privés du Center for Global Prosperity de l'Hudson Institute à la Lilly Family School of Philanthropy de l'Université de l'Indiana. Projet. Atténuer les risques de radicalisation violente chez les jeunes Maliens et Sénégalais. La région ...

Aims and Formats of performance measurement at Danish Universities

DEFF Research Database (Denmark)

Raffnsøe-Møller, Morten

2011-01-01

Abstract This article traces the aims and formats of performance measurement of Danish Universities as they originate from the Ministry of Finance’s plan for governance of the public sector. The article further show that the fierce conflicts between central administration and the universities over...... and intelligent regimes – is used to propose a way out of the current governance impasse at the universities....

Toolkit for local decision makers aims to strengthen environmental sustainability

CSIR Research Space (South Africa)

Murambadoro, M

2011-11-01

Full Text Available Members of the South African Risk and Vulnerability Atlas were involved in a meeting aimed at the development of a toolkit towards improved integration of climate change into local government's integrated development planning (IDP) process....

A RE-AIM evaluation of theory-based physical activity interventions.

Science.gov (United States)

Antikainen, Iina; Ellis, Rebecca

2011-04-01

Although physical activity interventions have been shown to effectively modify behavior, little research has examined the potential of these interventions for adoption in real-world settings. The purpose of this literature review was to evaluate the external validity of 57 theory-based physical activity interventions using the RE-AIM framework. The physical activity interventions included were more likely to report on issues of internal, rather than external validity and on individual, rather than organizational components of the RE-AIM framework, making the translation of many interventions into practice difficult. Furthermore, most studies included motivated, healthy participants, thus reducing the generalizability of the interventions to real-world settings that provide services to more diverse populations. To determine if a given intervention is feasible and effective in translational research, more information should be reported about the factors that affect external validity.

A review of intervention studies aimed at household energy conservation

NARCIS (Netherlands)

Abrahamse, W; Steg, L; Vlek, C; Rothengatter, T; Rothengatter, J.A.

This article reviews and evaluates the effectiveness of interventions aiming to encourage households to reduce energy consumption. Thirty-eight studies performed within the field of (applied) social and environmental psychology are reviewed, and categorized as involving either antecedent strategies

No norm needed: on the aim of belief

DEFF Research Database (Denmark)

Steglich-Petersen, Asbjørn

2006-01-01

Does transparency in doxastic deliberation entail a constitutive norm of correctness governing belief, as Shah and Velleman argue? No, because this presupposes an implausibly strong relation between normative judgements and motivation from such judgements, ignores our interest in truth, and cannot...... explain why we pay different attention to how much justification we have for our beliefs in different contexts. An alternative account of transparency is available: transparency can be explained by the aim one necessarily adopts in deliberating about whether to believe that p. To show this, I reconsider...... the role of the concept of belief in doxastic deliberation, and I defuse 'the teleologian's dilemma'....

Effects of Energy Beverage Consumption on Pistol Aiming Steadiness in Law Enforcement Officers.

Science.gov (United States)

Monaghan, Taylor P; Jacobson, Bert H; Sellers, John H; Estrada, Carlos A

2017-09-01

Monaghan, TP, Jacobson, BH, Sellers, JH, and Estrada, CA. Effects of energy beverage consumption on pistol aiming steadiness in law enforcement officers. J Strength Cond Res 31(9): 2557-2561, 2017-The popularity of energy drinks (EDs)/shots (ESs) has grown steadily over the years resulting in billions of dollars of sales annually. Energy drink marketing focuses on the improved performance and alertness and a reduction in fatigue. Although caffeine comprises one of the ingredients, it is not fully known how the combination of the many remaining active ingredients affects physical performance. The purpose of this study was to investigate the effect of a commercially available ES on pistol aiming steadiness. Subjects (N = 10) consisted of accredited police officers in the Midwest. A randomized, blinded, crossover design was used to evaluate the pistol aiming steadiness after the consumption of an ES or placebo. Pistol aiming steadiness was measured using a hole/stylus steadiness tester and laser attached to a training pistol before and 30 minutes after ES or placebo consumption. Analysis revealed that the ES significantly (p ≤ 0.05) impaired pistol steadiness, whereas the placebo yielded no significant difference in aiming steadiness. Based on these results, it was concluded that the consumption of an ES could compromise aiming accuracy and shot placement, thereby jeopardizing the health and welfare of law enforcement personnel.

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic Cells

Science.gov (United States)

Kawasaki, Akira; Matsumura, Itaru; Miyagawa, Jun-ichiro; Ezoe, Sachiko; Tanaka, Hirokazu; Terada, Yasuhiko; Tatsuka, Masaaki; Machii, Takashi; Miyazaki, Hiroshi; Furukawa, Yusuke; Kanakura, Yuzuru

2001-01-01

During the late phase of megakaryopoiesis, megakaryocytes undergo polyploidization, which is characterized by DNA duplication without concomitant cell division. However, it remains unknown by which mechanisms this process occurs. AIM-1 and STK15 belong to the Aurora/increase-in-ploidy (Ipl)1 serine/threonine kinase family and play key roles in mitosis. In a human interleukin-3–dependent cell line, F-36P, the expressions of AIM-1 and STK15 mRNA were specifically observed at G2/M phase of the cell cycle during proliferation. In contrast, the expressions of AIM-1 and STK15 were continuously repressed during megakaryocytic polyploidization of human erythro/megakaryocytic cell lines (F-36P, K562, and CMK) treated with thrombopoietin, activated ras (H-rasG12V), or phorbol ester. Furthermore, their expressions were suppressed during thrombopoietin-induced polyploidization of normal human megakaryocytes. Activation of AIM-1 by the induced expression of AIM-1(wild-type) canceled TPA-induced polyploidization of K562 cells significantly, whereas that of STK15 did not. Moreover, suppression of AIM-1 by the induced expression of AIM-1 (K/R, dominant-negative type) led to polyploidization in 25% of K562 cells, whereas STK15(K/R) showed no effect. Also, the induced expression of AIM-1(K/R) in CMK cells provoked polyploidization up to 32N. These results suggested that downregulation of AIM-1 at M phase may be involved in abortive mitosis and polyploid formation of megakaryocytes. PMID:11266445

Learning object for teacher training aimed to develop communication skills

Directory of Open Access Journals (Sweden)

Norma Esmeralda RODRÍGUEZ RAMÍREZ

2014-06-01

Full Text Available This article presents the results and reflections obtained across a research aimed to analyze the quality criteria of an opened learning object oriented to develop communication skills in order to be able to report and validate it according to its content, pedagogic structure, technological structure, graphical and textual language and usability to teacher training, in order to base it theoretically, pedagogically and technologically. The research question was: Which are the quality criteria that a learning object aimed to develop communication skills must cover? Under a quantitative approach, there were electronic questionnaires applied to: 34 Technological University teachers, eight experts about of communicative competence, teaching, technology and graphic design. The results indicated that some of the quality criteria of learning object are: the effective managing of the learning content, the balanced composition of his pedagogic structure, the technological structure efficiency and the proper managing of graphical and textual language.

Aiming of Kirkpatrick-Baez microscope based on auxiliary optical system

International Nuclear Information System (INIS)

Huang Shengling; Mu Baozhong; Yi Shengzhen; Wang Xin; Wang Zhanshan; Ding Yongkun; Miao Wenyong; Dong Jianjun

2009-01-01

An auxiliary optical system has been designed, which can provide precise positioning for aiming Kirkpatrick-Baez (KB) microscope object location. An 8 keV X-ray imaging system by KB microscope with periodic multilayer films has been designed. The field of view and depth of field in the resolution of 5 μm are got, and then the corresponding point and depth of field in diagnostic experiments are calculated. Based on the object-image relations and precision of the KB microscope, an auxiliary visible light imaging system is designed and X-ray imaging experiments are performed, which can achieve equivalent aiming between the visible imaging system and the KB microscope. The results show that ±20 μm vertical axis plane and ±300 μm axial accuracy are achieved through the auxiliary optical path, which can meet the object point positioning requirements of the KB microscope. (authors)

Fabrication and Characterization of Surrogate Glasses Aimed to Validate Nuclear Forensic Techniques

Science.gov (United States)

2017-12-01

the glass formed during a nuclear event, trinitite [14]. The SiO2 composition is generally greater than 50% for trinitite and can vary appreciably...CHARACTERIZATION OF SURROGATE GLASSES AIMED TO VALIDATE NUCLEAR FORENSIC TECHNIQUES by Ken G. Foos December 2017 Thesis Advisor: Claudia...December 2017 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE FABRICATION AND CHARACTERIZATION OF SURROGATE GLASSES AIMED TO

Ocean Science Video Challenge Aims to Improve Science Communication

Science.gov (United States)

Showstack, Randy

2013-10-01

Given today's enormous management and protection challenges related to the world's oceans, a new competition calls on ocean scientists to effectively communicate their research in videos that last up to 3 minutes. The Ocean 180 Video Challenge, named for the number of seconds in 3 minutes, aims to improve ocean science communication while providing high school and middle school teachers and students with new and interesting educational materials about current science topics.

On correlations in IMRT planning aims

Science.gov (United States)

Roy, Arkajyoti; Das, Indra J.

2016-01-01

The purpose was to study correlations amongst IMRT DVH evaluation points and how their relaxation impacts the overall plan. 100 head‐and‐neck cancer cases, using the Eclipse treatment planning system with the same protocol, are statistically analyzed for PTV, brainstem, and spinal cord. To measure variations amongst the plans, we use (i) interquartile range (IQR) of volume as a function of dose, (ii) interquartile range of dose as a function of volume, and (iii) dose falloff. To determine correlations for institutional and ICRU goals, conditional probabilities and medians are computed. We observe that most plans exceed the median PTV dose (average D50 = 104% prescribed dose). Furthermore, satisfying D50 reduced the probability of also satisfying D98, constituting a negative correlation of these goals. On the other hand, satisfying D50 increased the probability of satisfying D2, suggesting a positive correlation. A positive correlation is also observed between the PTV V105 and V110. Similarly, a positive correlation between the brainstem V45 and V50 is measured by an increase in the conditional median of V45, when V50 is violated. Despite the imposed institutional and international recommendations, significant variations amongst DVH points can occur. Even though DVH aims are evaluated independently, sizable correlations amongst them are possible, indicating that some goals cannot be satisfied concurrently, calling for unbiased plan criteria. PACS number(s): 87.55.dk, 87.53.Bn, 87.55.Qr, 87.55.de. PMID:27929480

Anxiety and ironic effects in aiming at a far target

NARCIS (Netherlands)

Bakker, F.C.; Binsch, O.

2011-01-01

In far aiming the negative intention not to miss may ironically increase the tendency to do precisely that. Although cognitive constraints enhance the occurrence of ironic effects in the perceptual-motor domain the role of anxiety in inducing such effects has rarely been investigated while anxiety

Effects of Direction and Index of Difficulty on Aiming Movements after Stroke

Directory of Open Access Journals (Sweden)

Paola Ribeiro Coqueiro

2014-01-01

Full Text Available Background. Brain hemispheres play different roles in the control of aiming movements that are impaired after unilateral stroke. It is not clear whether those roles are influenced by the direction and the difficulty of the task. Objective. To evaluate the influence of direction and index of difficulty (ID of the task on performance of ipsilesional aiming movements after unilateral stroke. Methods. Ten individuals with right hemisphere stroke, ten with left hemisphere stroke, and ten age- and gender-matched controls performed the aiming movements on a digitizing tablet as fast as possible. Stroke individuals used their ipsilesional arm. The direction (ipsilateral or contralateral, size (0.8 or 1.6 cm, and distance (9 or 18 cm of the targets, presented on a monitor, were manipulated and determined to be of different ID (3.5, 4.5, and 5.5. Results. Individuals with right hemisphere lesion were more sensitive to ID of the task, affecting planning and final position accuracy. Left hemisphere lesion generated slower and less smooth movements and was more influenced by target distance. Contralateral movements and higher ID increased planning demands and hindered movement execution. Conclusion. Right and left hemisphere damages are differentially influenced by task constraints which suggest their complementary roles in the control of aiming movements.

Retrospective study of thyroid cancer treatment: aims and data

International Nuclear Information System (INIS)

Vosmikova, K.; Hermanska, J.; Jirsa, L.; Karny, M.; Samal, M.

1998-01-01

Although opinions preferring individual administration of activity in the treatment of thyroid cancer with 131 I predominate, sufficient quantitative arguments in favor of this approach are unavailable as yet. Therefore, a retrospective study involving statistical processing was proposed with the aim to evaluate the relations between available data of the patients and success of treatment. Ideally, recommendations regarding activity to be administered in dependence on the biophysical status of the patient should emerge from the study

Postinjection delirium/sedation syndrome in patients with schizophrenia receiving olanzapine long-acting injection: results from a large observational study.

Science.gov (United States)

Meyers, Kristin J; Upadhyaya, Himanshu P; Landry, John L; Chhabra-Khanna, Rashna; Falk, Deborah M; Seetharama Rao, Balasubramanya; Jones, Meghan E

2017-07-01

Postinjection delirium/sedation syndrome (PDSS) has been reported uncommonly during treatment with olanzapine long-acting injection (LAI), a sustained-release formulation of olanzapine. The primary aim of the study was to estimate the incidence per injection and per patient of PDSS events in adult patients with schizophrenia who were receiving olanzapine LAI in real-world clinical practice. Secondary aims were to further characterise the clinical presentation of PDSS events, to identify potential risk factors associated with PDSS events and to characterise hospitalisations at baseline and post-baseline. A prospective observational study of adult patients with schizophrenia receiving olanzapine LAI from 24 countries. Data were collected on patient characteristics, olanzapine LAI treatment and any adverse events (AEs). All AEs were reviewed and adjudicated for PDSS using predetermined criteria. There were 46 confirmed PDSS events (0.044% of the 103 505 injections) in 45 patients (1.17% of the 3858 patients). Based on 45 confirmed events with time-to-onset information, 91.1% ( n =41) occurred within 1 h of injection. Time-to-recovery from the event was within 72 h for 95.6% of patients (range 6 h to 11 days). Risk factors for PDSS (per-injection) included high dose (odds ratio (OR) high/low =3.95; P =0.006) and male gender (OR female/male =0.42; P =0.017). Results of this study confirm previously reported PDSS rates, time to onset and recovery, and the severity of PDSS events, and suggest that higher doses and male gender are potential risk factors associated with PDSS. All authors are full-time employees and hold stock/stock options in Eli Lilly, which funded this study. This post-authorisation safety study (PASS) was proposed by Eli Lilly when submitting the original marketing authorisation application for olanzapine LAI in 2007. The protocol and final study report for this European Union regulatory commitment are publicly accessible via the European Network of

R. S. Peters' Normative Conception of Education and Educational Aims

Science.gov (United States)

Katz, Michael S.

2009-01-01

This article aims to highlight why R. S. Peters' conceptual analysis of "education" was such an important contribution to the normative field of philosophy of education. In the article, I do the following: 1) explicate Peters' conception of philosophy of education as a field of philosophy and explain his approach to the philosophical analysis of…

Thirty years of artificial intelligence in medicine (AIME) conferences: A review of research themes.

Science.gov (United States)

Peek, Niels; Combi, Carlo; Marin, Roque; Bellazzi, Riccardo

2015-09-01

Over the past 30 years, the international conference on Artificial Intelligence in MEdicine (AIME) has been organized at different venues across Europe every 2 years, establishing a forum for scientific exchange and creating an active research community. The Artificial Intelligence in Medicine journal has published theme issues with extended versions of selected AIME papers since 1998. To review the history of AIME conferences, investigate its impact on the wider research field, and identify challenges for its future. We analyzed a total of 122 session titles to create a taxonomy of research themes and topics. We classified all 734 AIME conference papers published between 1985 and 2013 with this taxonomy. We also analyzed the citations to these conference papers and to 55 special issue papers. We identified 30 research topics across 12 themes. AIME was dominated by knowledge engineering research in its first decade, while machine learning and data mining prevailed thereafter. Together these two themes have contributed about 51% of all papers. There have been eight AIME papers that were cited at least 10 times per year since their publication. There has been a major shift from knowledge-based to data-driven methods while the interest for other research themes such as uncertainty management, image and signal processing, and natural language processing has been stable since the early 1990s. AIME papers relating to guidelines and protocols are among the most highly cited. Copyright © 2015 Elsevier B.V. All rights reserved.

Resource use and costs of exenatide bid or insulin in clinical practice: the European CHOICE study

Directory of Open Access Journals (Sweden)

Kiiskinen U

2013-07-01

Full Text Available Urpo Kiiskinen,1 Stephan Matthaei,2 Matthew Reaney,3 Chantal Mathieu,4 Claes-Göran Östenson,5 Thure Krarup,6 Michael Theodorakis,7,* Jacek Kiljanski,8 Carole Salaun-Martin,9 Hélène Sapin,9 Bruno Guerci10 1Eli Lilly, Helsinki, Finland; 2Quakenbrück Diabetes Center, Quakenbrück, Germany; 3Eli Lilly, Windlesham, Surrey, UK; 4Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium; 5Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 6Department of Endocrinology, Bispebjerg Hospital, Copenhagen, Denmark; 7Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece; 8Eli Lilly, Warsaw, Poland; 9Eli Lilly, Neuilly Cedex, France; 10Department of Diabetes, Metabolic Diseases, and Nutrition, Hôpital Brabois, Vandoeuvre-Lès-Nancy, France *Michael Theodorakis was affiliated with the institution shown above at the time of the study, but has since left this institution Purpose: CHOICE (CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy assessed patterns of exenatide bid and initial insulin therapy usage in clinical practice in six European countries and evaluated outcomes during the study. Methods: CHOICE was a 24-month, prospective, noninterventional observational study. Clinical and resource use data were collected at initiation of first injectable therapy (exenatide bid or insulin and at regular intervals for 24 months. Costs were evaluated from the national health care system perspective at 2009 prices. Results: A total of 2515 patients were recruited. At the 24-month analysis, significant treatment change had occurred during the study in 42.2% of 1114 eligible patients in the exenatide bid cohort and 36.0% of 1274 eligible patients in the insulin cohort. Improvements in glycemic control were observed over the course of the study in both cohorts (P < 0.001 for both, but mean weight was reduced in the exenatide bid cohort (P < 0

Treatment outcomes after initiation of exenatide twice daily or insulin in clinical practice: 12-month results from CHOICE in six European countries

Directory of Open Access Journals (Sweden)

Ostenson CG

2013-04-01

Full Text Available Claes-Göran Östenson,1 Stephan Matthaei,2 Matthew Reaney,3 Thure Krarup,4 Bruno Guerci,5 Jacek Kiljanski,6 Carole Salaun-Martin,7 Hélène Sapin,7 David Bruhn,8 Chantal Mathieu,9 Michael Theodorakis10 1Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; 2Diabetes-Center Quakenbrück, Quakenbrück, Germany; 3Eli Lilly, Windlesham, Surrey, UK; 4Department of Endocrinology I, Bispebjerg Hospital, Copenhagen, Denmark; 5Diabetology, Metabolic Diseases and Nutrition, Brabois Hospital, CHU Nancy, and INSERM CIC, ILCV, Vandoeuvre Lès Nancy, France; 6Eli Lilly, Warsaw, Poland; 7Eli Lilly, Neuilly Cedex, France; 8Eli Lilly, San Diego, California, USA; 9Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium; 10Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece* *Michael Theodorakis was affiliated with the institution shown at the time of the study, but has since left this institution Objective: The CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy (CHOICE study assessed time to, and reasons for, significant treatment change after patients with type 2 diabetes (T2DM initiated their first injectable glucose-lowering therapy (exenatide twice daily [BID] or insulin in routine clinical practice, and these patients’ clinical outcomes, in six European countries. This paper reports interim data from the first 12 months of the study. Research design and methods: CHOICE (NCT00635492 is a prospective, noninterventional, observational study. Clinical data were collected at initiation of first injectable therapy and after approximately 3, 6, and 12 months. Results: Of 2497 patients enrolled in CHOICE, 1096 in the exenatide BID and 1239 in the insulin cohorts had ≥1 post-baseline assessment and were included in this analysis. Overall, 32.2% of the exenatide BID cohort and 29.1% of the insulin cohort (Kaplan–Meier estimates had

Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes

International Nuclear Information System (INIS)

Iwamura, Yoshihiro; Mori, Mayumi; Nakashima, Katsuhiko; Mikami, Toshiyuki; Murayama, Katsuhisa; Arai, Satoko; Miyazaki, Toru

2012-01-01

Highlights: ► AIM induces lipolysis in a distinct manner from that of hormone-dependent lipolysis. ► AIM ablates activity of peroxisome proliferator-activated receptor in adipocytes. ► AIM reduces mRNA levels of lipid-droplet coating proteins leading to lipolysis. -- Abstract: Under fasting conditions, triacylglycerol in adipose tissue undergoes lipolysis to supply fatty acids as energy substrates. Such lipolysis is regulated by hormones, which activate lipases via stimulation of specific signalling cascades. We previously showed that macrophage-derived soluble protein, AIM induces obesity-associated lipolysis, triggering chronic inflammation in fat tissue which causes insulin resistance. However, the mechanism of how AIM mediates lipolysis remains unknown. Here we show that AIM induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases. In vivo and in vitro, AIM did not enhance phosphorylation of hormone-sensitive lipase (HSL) in adipocytes, a hallmark of hormone-dependent lipolysis activation. Similarly, adipose tissue from obese AIM-deficient and wild-type mice showed comparable HSL phosphorylation. Consistent with the suppressive effect of AIM on fatty acid synthase activity, the amount of saturated and unsaturated fatty acids was reduced in adipocytes treated with AIM. This response ablated transcriptional activity of peroxisome proliferator-activated receptor (PPARγ), leading to diminished gene expression of lipid-droplet coating proteins including fat-specific protein 27 (FSP27) and Perilipin, which are indispensable for triacylglycerol storage in adipocytes. Accordingly, the lipolytic effect of AIM was overcome by a PPARγ-agonist or forced expression of FSP27, while it was synergized by a PPARγ-antagonist. Overall, distinct modes of lipolysis appear to take place in different physiological situations; one is a supportive response against nutritional deprivation achieved by

AN ADAPTIVE ACO-DRIVEN SCHEME FOR LEARNING AIM ORIENTED PERSONALIZED E-LEARNING

Directory of Open Access Journals (Sweden)

Sushma Hans

2014-10-01

Full Text Available The e-learning paradigm is now a well-established vehicle of modern education. It caters to a wide spectrum of students with diverse backgrounds who enroll with their own learning aims. A core challenge under this scenario is to generate personalized learning paths so that each student can achieve her learning aim most effectively. Prior works used static attributes such as prior knowledge level, learning ability, browsing preferences, learning style etc. to generate personalized learning paths. In this paper, we take an entirely new route by taking into account the continuous improvement of a learner in the light of her own learning aim, to redefine her learning path at each level of the course. We introduce the concept of personalized examination system that systematically evaluates the dynamic learning ability of every student according to her pre-set goals. The proposed intelligent e-learning system uses Ant Colony Optimization to iteratively optimize the forward learning paths. Experimental results reveal that the system is able to tap a student’s improved learning ability to choose more difficult paths that contribute highly towards her own aims. We demonstrate that the overall learning success of weaker students doubles as compared to statically generated paths while there is considerable improvement of 50% in the learning success for average students as well. This clearly indicates that our approach gives realistic benefits to initially weak students who gradually evolve as the course progresses.

Incorporating Level-2 PSA Feature of CONPAS into AIMS-PSA Software

International Nuclear Information System (INIS)

Han, Sang Hoon; Lim, Hogon; Ahn, Kwang Il

2014-01-01

CONPAS (CONtainment Performance Analysis System) utilizes a methodology to treat containment phenomena in detail like APET but in simple way. In mid 2000's, KAERI has developed very fast cut set generator FTREX and PC's OS (Operating system) has changed into Windows 95. Thus, KAERI has developed new Level-1 PSA software, called AIMS-PSA (Advanced Information Management System for PSA) to replace KIRAP. Recently, KAERI has been developing an integrated PSA platform, called OCEANS (On-line Consolidator and Evaluator of All mode risk for Nuclear System), for the risk assessment of all power modes and all hazards. CONPAS for Level-2 PSA was developed in 1990's using the Visual Basic 6.0 compiler which is not supported any more. It needs to be updated for the integrated PSA software framework. This paper describes a study to incorporate the features of CONPAS into AIMS-PSA. The basic idea is to follow the approach of CONPAS, but in the integrated way. Various approaches for Level-2 PSA have been used since WASH-1400. APET approach of NUREG-1150 study would be most comprehensive and complex methodology for containment event tree analysis. CONPAS is the Level-2 PSA software to utilize an approach to treat containment phenomena in detail like APET but in simple way. But, new Level-2 PSA software is required to develop more integrated PSA framework. A modified approach of CONPAS is developed and incorporated in AIMS-PSA software that can handle Level-1 and Level-2 PSA in the integrated way (from the viewpoint of event tree and fault tree). AIMS-PSA combines whole Level-2 PSA model to produce a One Top fault tree and to generate cut sets in the same way as Level-1 PSA. Quantification results of Level-2 PSA such as frequency for each STC can be calculated from the minimal cut sets

Savannah River Plant's Accountability Inventory Management System (AIMS) (Nuclear materials inventory control)

International Nuclear Information System (INIS)

Croom, R.G.

1976-06-01

The Accountability Inventory Management System (AIMS) is a new computer inventory control system for nuclear materials at the Savannah River Plant, Aiken, South Carolina. The system has two major components, inventory files and system parameter files. AIMS, part of the overall safeguards program, maintains an up-to-date record of nuclear material by location, produces reports required by ERDA in addition to onplant reports, and is capable of a wide range of response to changing input/output requirements through use of user-prepared parameter cards, as opposed to basic system reprogramming

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Directory of Open Access Journals (Sweden)

Shuiqing Hu

2015-12-01

Full Text Available Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown. Here, we show that Aim2−/− mice are highly susceptible to dextran sodium sulfate-induced colitis that is associated with microbial dysbiosis as represented by higher colonic burden of commensal Escherichia coli. Colonization of germ-free mice with Aim2−/− mouse microbiota leads to higher colitis susceptibility. In-depth investigation of AIM2-mediated host defense responses reveals that caspase-1 activation and IL-1β and IL-18 production are compromised in Aim2−/− mouse colons, consistent with defective inflammasome function. Moreover, IL-18 infusion reduces E. coli burden as well as colitis susceptibility in Aim2−/− mice. Altered microbiota in inflammasome-defective mice correlate with reduced expression of several antimicrobial peptides in intestinal epithelial cells. Together, these findings implicate DNA sensing by AIM2 as a regulatory mechanism for maintaining intestinal homeostasis.

Wander Lust: Genre, Sexuality and Identity in Ana Kokkinos’s Head On

Directory of Open Access Journals (Sweden)

Joe Hardwick

2011-04-01

Full Text Available While the road movie has long held a privileged place in Australian cinema, less prevalent, though increasingly present, has been the street movie, which—like its road movie cousin—poses important questions about identity in tracing the trajectory of its wanderer protagonists. The most remarkable recent example of an Australian street movie is Ana Kokkinos’s 1997 feature Head On. The film recounts a day in the life of a late adolescent Greek-Australian male who wanders the streets participating in sexual encounters with mainly, though not exclusively, other men. Whereas reviews and articles have generally read the film as a coming out narrative, this article—with reference to Ross Chambers’ theories on digressive narratives in his book Loiterature—will argue that Head On rejects the simplistic teleology of the coming out story in favour of a much more complex understanding of adolescent male sexuality.

Agricultural labourers and their wages in Estland in 1885-1913 / Kersti Lust

Index Scriptorium Estoniae

Lust, Kersti, 1976-

2007-01-01

Eesti maatööliste palgast ja selles "moderniseerumise" ajal toimunud muutustest Põhja-Eesti mõisatööliste näitel. Nihkeid maatööliste ostujõus on püütud hinnata rukki ja või hindade alusel konstrueeritud indeksi abil

Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes

Energy Technology Data Exchange (ETDEWEB)

Iwamura, Yoshihiro; Mori, Mayumi; Nakashima, Katsuhiko [Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mikami, Toshiyuki; Murayama, Katsuhisa [Genomic Science Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-0022 (Japan); Arai, Satoko [Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Miyazaki, Toru, E-mail: tm@m.u-tokyo.ac.jp [Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

2012-06-08

Highlights: Black-Right-Pointing-Pointer AIM induces lipolysis in a distinct manner from that of hormone-dependent lipolysis. Black-Right-Pointing-Pointer AIM ablates activity of peroxisome proliferator-activated receptor in adipocytes. Black-Right-Pointing-Pointer AIM reduces mRNA levels of lipid-droplet coating proteins leading to lipolysis. -- Abstract: Under fasting conditions, triacylglycerol in adipose tissue undergoes lipolysis to supply fatty acids as energy substrates. Such lipolysis is regulated by hormones, which activate lipases via stimulation of specific signalling cascades. We previously showed that macrophage-derived soluble protein, AIM induces obesity-associated lipolysis, triggering chronic inflammation in fat tissue which causes insulin resistance. However, the mechanism of how AIM mediates lipolysis remains unknown. Here we show that AIM induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases. In vivo and in vitro, AIM did not enhance phosphorylation of hormone-sensitive lipase (HSL) in adipocytes, a hallmark of hormone-dependent lipolysis activation. Similarly, adipose tissue from obese AIM-deficient and wild-type mice showed comparable HSL phosphorylation. Consistent with the suppressive effect of AIM on fatty acid synthase activity, the amount of saturated and unsaturated fatty acids was reduced in adipocytes treated with AIM. This response ablated transcriptional activity of peroxisome proliferator-activated receptor (PPAR{gamma}), leading to diminished gene expression of lipid-droplet coating proteins including fat-specific protein 27 (FSP27) and Perilipin, which are indispensable for triacylglycerol storage in adipocytes. Accordingly, the lipolytic effect of AIM was overcome by a PPAR{gamma}-agonist or forced expression of FSP27, while it was synergized by a PPAR{gamma}-antagonist. Overall, distinct modes of lipolysis appear to take place in different physiological

En utvärdering av huvudmonterade displays - En ny uppväckning inom virtuell verklighet

OpenAIRE

Ostrow, Alexander

2015-01-01

Tekniken bakom den virtuella verkligheten är nära att komma ut på marknaden igen på ett mer imponerande sätt än förr. Sedan tekniken misslyckades att övertyga publiken på 1990-talet, hade ingen lust att ta det mer på allvar, redan själva termen virtuell verklighet skrämde många och fick därför ett dåligt rykte. År 2012 förändrades allt, när bolaget med namnet Oculus utvecklade en apparat som kallades Oculus Rift. Apparaten var en så kallad huvudmonterad display, som används för att uppleva en...

Vanadust käsitlev projekt Tallinna Kunstihoones

Index Scriptorium Estoniae

2005-01-01

Tallinna Kunstihoones Reet Varblase kureeritud näitus "Homo grandis natu", mis käsitleb vanaduse ja vananemise tähendust ja rolli praeguses ühiskonnas. Osalejaid: Boaz Tal, Eveli Varik, Ly Lestberg, Mare Mikof, Aili Vahtrapuu, Jaan Paavle, Terje Ojaver, Marge Monko, Terje Tunis, Tatjana Antoshina, Valeri Vinogradov, Peeter Laurits, Toomas Kalve, Jüri Ojaver. 15. IV toimuva seminari "Eesti vananemispoliitika täna ja homme" ning 21., 28. IV, 5., 12. V toimuva loengusarja kava. 16. IV peab Boaz Tal loengu arhetüüpidest ja mälust, tutvustab oma töid. 21. IV avatakse Katarzyna Kozyra videoinstallatsioon "Naiste saun". 2. V performance'i-festival "Diverse universe", loetletud osalejaid

Introduction to bosonic string theory

Energy Technology Data Exchange (ETDEWEB)

Nunez, Carmen [Instituto de Astronomia y Fisica del Espacio, Buenos Aires (Argentina)], e-mail: carmen@iafe.uba.ar

2009-07-01

This is an introductory set of five lectures on bosonic string theory. The first one deals with the classical theory of bosonic strings. The second and third lectures cover quantization. Three basic quantization methods are sketched: the old covariant formalism, the light-cone gauge quantization, where the spectrum is derived and the Polyakov path integral formalism and in particular the partition function at one loop. Finally, the last lecture covers interactions, low energy effective action, the general idea of compactification and in particular toroidal compactification. The notes are based on books by Green, Schwarz and Witten, Polchinski, Lust and Theissen and Kaku and review papers by D'Hocker and Phong and O. Alvarez. (author)

Characterization of electric arc furnace dust aiming reuse

International Nuclear Information System (INIS)

Grillo, F.F.; Oliveira, E.B.G.; Oliveira, J.R. de; Telles, V.B.; Tenorio, J.A.S.

2010-01-01

This work aims to study the characterize of steelmaking dust, from the primary refining of steel in Electric Arc Furnace, in order to verify feasibility of reuse through the addition of hot metal in the form of briquette. The techniques used to characterize the dust was chemical analyses, size separation tests, X-ray diffraction analyses (XRD), Scanning Electron Microscopy (SEM). After characterization, was the calculation of reductant considering the complete reduction of iron oxides and then to briquetting. The waste sample is composed essentially of spherical particles and has a very small particle size (85% below 10 μm). The XRD has presented compounds such as ZnFe 2 O 4 , Fe 3 O 4 , ZnO e SiO 2 . This work showed that its possible recovery approximately 92% of metal iron from dust generated during steelmaking.This (author)

Longevidade de inflorescências de lírio, de diferentes estádios de colheita, pré-tratadas com sacarose e tiossulfato de prata (STS Longevity of lilly inflorescences harvested at different stages of development and pulsed with sucrose and silver thiosulfate (STS

Directory of Open Access Journals (Sweden)

José Geraldo Barbosa

2006-02-01

flowers at different ages. They were evaluated at length and opening of the buds, relative water content, content of chlorophyll and longevity. The longevity of lilly flowers variety Ace is influenced by the stage of harvest, with longer longevity for the younger stage, A. Inflorescences harvested at stage A and pulsed with STS had bigger diameter, but the treatment reduced the bud opening and flower quality. The sucrose improved the opening of buds harvested at stage A and increased the flower vase life. Thus the use of sucrose at 5% allowed harvesting the inflorescences at earlier stage, increasing the flower vase life.

Morphological Characterization of the Frontal and Parietal Bones of the Human Skull

Science.gov (United States)

2017-03-01

the image stack. Finally, the images were converted from gray scale to a binary format for the quantitative image analysis. An automated algorithm...validation with micro-CT. J of Anatomy . 2015;226(1):73–80. Lillie EM, Urban JE, Lynch SK, Weaver AA, Stitzel JD. Evaluation of skull cortical thickness... gray -level histograms. Automatica. 1975;11.285(296):23–27. Peterson J, Dechow PC. Material properties of the inner and outer cortical tables of the

Energy challenges and strategic challenges in the 21. Century

International Nuclear Information System (INIS)

Paillard, Christophe-Alexandre

2011-01-01

Prices of fossil fuels are still increasing in 2011. This trend should accentuate in the next years. Because natural resources are indeed limited and without any possibility of quickly reversing current consuming habits, world consumers must find a way to limit the impact of these bullish tendencies. This challenge must be confronted to the lack of credible alternative to fossil fuels. In fact, there is no energy with comparable qualities to oil and gas. Thus other resources will keep a low profile in the world energy balance in the next twenty years. This phenomenon of scarcity and a high level of dependency to hydrocarbons will have four consequences: redefinition of military and economic alliances; calling into questions the positions of established powers; implementation of policies which aim to reduce any external dependency; upholding of the Middle East as a key energy area, due to the amount of its natural reserves. In such a context, producing countries will try to preserve their resources from any external lust. For all, any energy policy based on abstinence should contribute to limit the risks of a possible world energy crisis. However, such a development seems to be unlikely on the mid term. Energy will stay one of the major challenges of the 21. century

Personality Influences the Relationship Between Primary Emotions and Religious/Spiritual Well-Being

Science.gov (United States)

Hiebler-Ragger, Michaela; Fuchshuber, Jürgen; Dröscher, Heidrun; Vajda, Christian; Fink, Andreas; Unterrainer, Human F.

2018-01-01

The study of human emotions and personality provides valuable insights into the parameters of mental health and well-being. Affective neuroscience proposes that several levels of emotions – ranging from primary ones such as LUST or FEAR up to higher emotions such as spirituality – interact on a neural level. The present study aimed to further explore this theory. Furthermore, we hypothesized that personality – formed by bottom-up primary emotions and cortical top-down regulation – might act as a link between primary emotions and religious/spiritual well-being. A total sample of 167 (78% female) student participants completed the Affective Neuroscience Personality Scale (primary emotions), the Big Five Personality Inventory and the Multidimensional Inventory of Religious/Spiritual Well-Being (higher emotions). Correlation analyses confirmed the link between primary and higher emotions as well as their relation to personality. Further regression analyses indicated that personality dimensions mediate the relationship between primary and higher emotions. A substantial interaction between primary emotions, personality dimensions, and religious/spiritual well-being could be confirmed. From a developmental perspective, cortical top-down regulation might influence religious/spiritual well-being by forming relevant personality dimensions. Hence, CARE as well as Agreeableness seem of special importance. Future studies might focus on implications for clinical groups. PMID:29615950

Introducing a "Balance" in The BSC Through Beauty and Love

Directory of Open Access Journals (Sweden)

Ari Kamayanti

2010-04-01

Full Text Available Celebrating the seventeenth anniversary of the Balanced Score Card (BSC since it was born in 1992, this paper revisits its concept as one of the landmarks in performance measurement. The BSC turns out to be ‘not so balanced’ since it lacks certain beauty and love. It hinges on accountability for certain interests when measuring performance, negating or putting other interests as minority. Thus, it fits perfectly with the aim of management accounting that puts managers and customers as priorities. The imbalances comes from secularism and overemphasis in rationalism. Sustainability that becomes the current issue nowadays would not be supported by such performance measurement. In order to insert this balance, a methodology by taking a methapor of nurturing mother is applied in this research that encompasses gentle beauty and subtle love. Gentle beauty refers to a complete harmony of beauty : irrational and the rational; this means introducing those that have been left out in the name of rationality such as religions and spiritualism. Subtle love refers to love towards God that is expressed subtly without lust to overpower. The result is a more balanced set of performance measurements that are filled with beauty and love, insyaAllah.

Personality Influences the Relationship Between Primary Emotions and Religious/Spiritual Well-Being.

Science.gov (United States)

Hiebler-Ragger, Michaela; Fuchshuber, Jürgen; Dröscher, Heidrun; Vajda, Christian; Fink, Andreas; Unterrainer, Human F

2018-01-01

The study of human emotions and personality provides valuable insights into the parameters of mental health and well-being. Affective neuroscience proposes that several levels of emotions - ranging from primary ones such as LUST or FEAR up to higher emotions such as spirituality - interact on a neural level. The present study aimed to further explore this theory. Furthermore, we hypothesized that personality - formed by bottom-up primary emotions and cortical top-down regulation - might act as a link between primary emotions and religious/spiritual well-being. A total sample of 167 (78% female) student participants completed the Affective Neuroscience Personality Scale (primary emotions), the Big Five Personality Inventory and the Multidimensional Inventory of Religious/Spiritual Well-Being (higher emotions). Correlation analyses confirmed the link between primary and higher emotions as well as their relation to personality. Further regression analyses indicated that personality dimensions mediate the relationship between primary and higher emotions. A substantial interaction between primary emotions, personality dimensions, and religious/spiritual well-being could be confirmed. From a developmental perspective, cortical top-down regulation might influence religious/spiritual well-being by forming relevant personality dimensions. Hence, CARE as well as Agreeableness seem of special importance. Future studies might focus on implications for clinical groups.

Primary emotional traits in patients with personality disorders.

Science.gov (United States)

Karterud, Sigmund; Pedersen, Geir; Johansen, Merete; Wilberg, Theresa; Davis, Ken; Panksepp, Jaak

2016-11-01

There is a longstanding tradition that connects temperament pathology and personality disorders. Emotions are the major constituents of temperament. In mammals, seven primary emotions have been identified: SEEKING, FEAR, CARE, RAGE, SADNESS/PANIC, LUST and PLAY. The study aimed at exploring the relationship between primary emotions and personality disorders (PDs). Five hundred forty-six patients with different degrees and qualities of personality pathology, admitted to treatment in specialized PD services, were diagnosed according to Structured Clinical Interview for DSM-IV Axis II Personality Disorders, and their primary emotional profiles were assessed by the Affective Neuroscience Personality Scales. The Affective Neuroscience Personality Scales explained 19% of the variance in borderline and avoidant criteria. The DSM-IV PD categories displayed different patterns of association to the primary emotions, e.g. the borderline PD profile suggested low thresholds for RAGE and SADNESS, but on the positive side a propensity for SEEKING. In contrast, the dependent PD profile suggested a low threshold for SADNESS but a high threshold for RAGE and SEEKING. The results are promising for a more coherent and evolution-based overall theory of PDs, and the correlations found in this study indicate testable causal pathways to PDs. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Personality Influences the Relationship Between Primary Emotions and Religious/Spiritual Well-Being

Directory of Open Access Journals (Sweden)

Michaela Hiebler-Ragger

2018-03-01

Full Text Available The study of human emotions and personality provides valuable insights into the parameters of mental health and well-being. Affective neuroscience proposes that several levels of emotions – ranging from primary ones such as LUST or FEAR up to higher emotions such as spirituality – interact on a neural level. The present study aimed to further explore this theory. Furthermore, we hypothesized that personality – formed by bottom-up primary emotions and cortical top-down regulation – might act as a link between primary emotions and religious/spiritual well-being. A total sample of 167 (78% female student participants completed the Affective Neuroscience Personality Scale (primary emotions, the Big Five Personality Inventory and the Multidimensional Inventory of Religious/Spiritual Well-Being (higher emotions. Correlation analyses confirmed the link between primary and higher emotions as well as their relation to personality. Further regression analyses indicated that personality dimensions mediate the relationship between primary and higher emotions. A substantial interaction between primary emotions, personality dimensions, and religious/spiritual well-being could be confirmed. From a developmental perspective, cortical top-down regulation might influence religious/spiritual well-being by forming relevant personality dimensions. Hence, CARE as well as Agreeableness seem of special importance. Future studies might focus on implications for clinical groups.

Development and application of the RE-AIM QuEST mixed methods framework for program evaluation.

Science.gov (United States)

Forman, Jane; Heisler, Michele; Damschroder, Laura J; Kaselitz, Elizabeth; Kerr, Eve A

2017-06-01

To increase the likelihood of successful implementation of interventions and promote dissemination across real-world settings, it is essential to evaluate outcomes related to dimensions other than Effectiveness alone. Glasgow and colleagues' RE-AIM framework specifies four additional types of outcomes that are important to decision-makers: Reach, Adoption, Implementation (including cost), and Maintenance. To further strengthen RE-AIM, we propose integrating qualitative assessments in an expanded framework: RE-AIM Qualitative Evaluation for Systematic Translation (RE-AIM QuEST), a mixed methods framework. RE-AIM QuEST guides formative evaluation to identify real-time implementation barriers and explain how implementation context may influence translation to additional settings. RE-AIM QuEST was used to evaluate a pharmacist-led hypertension management intervention at 3 VA facilities in 2008-2009. We systematically reviewed each of the five RE-AIM dimensions and created open-ended companion questions to quantitative measures and identified qualitative and quantitative data sources, measures, and analyses. To illustrate use of the RE-AIM QuEST framework, we provide examples of real-time, coordinated use of quantitative process measures and qualitative methods to identify site-specific issues, and retrospective use of these data sources and analyses to understand variation across sites and explain outcomes. For example, in the Reach dimension, we conducted real-time measurement of enrollment across sites and used qualitative data to better understand and address barriers at a low-enrollment site. The RE-AIM QuEST framework may be a useful tool for improving interventions in real-time, for understanding retrospectively why an intervention did or did not work, and for enhancing its sustainability and translation to other settings.

Is the AIMS65 score useful in predicting outcomes in peptic ulcer bleeding?

Science.gov (United States)

Jung, Sung Hoon; Oh, Jung Hwan; Lee, Hye Yeon; Jeong, Joon Won; Go, Se Eun; You, Chan Ran; Jeon, Eun Jung; Choi, Sang Wook

2014-02-21

To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer bleeding. This was a retrospective study in a single center between January 2006 and December 2011. We enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency room. High-risk patients were regarded as those who had re-bleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room. A total of 149 patients with peptic ulcer bleeding were analysed, and the AIMS65 score was used to retrospectively predict the high-risk patients. A total of 149 patients with peptic ulcer bleeding were analysed. The poor outcome group comprised 28 patients [male: 23 (82.1%) vs female: 5 (10.7%)] while the good outcome group included 121 patients [male: 93 (76.9%) vs female: 28 (23.1%)]. The mean age in each group was not significantly different. The mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group (P = 0.072). For the prediction of poor outcome, the AIMS65 score had a sensitivity of 35.5% (95%CI: 27.0-44.8) and a specificity of 82.1% (95%CI: 63.1-93.9) at a score of 0. The AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding (area under curve = 0.571; 95%CI: 0.49-0.65). The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer bleeding. Low albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding.

The multinational birth cohort of EuroPrevall: background, aims and methods

NARCIS (Netherlands)

Keil, T.; McBride, D.; Grimshaw, K.; Niggemann, B.; Xepapadaki, P.; Zannikos, K.; Sigurdardottir, S. T.; Clausen, M.; Reche, M.; Pascual, C.; Stanczyk, A. P.; Kowalski, M. L.; Dubakiene, R.; Drasutiene, G.; Roberts, G.; Schoemaker, A.-F. A.; Sprikkelman, A. B.; Fiocchi, A.; Martelli, A.; Dufour, S.; Hourihane, J.; Kulig, M.; Wjst, M.; Yazdanbakhsh, M.; Szépfalusi, Z.; van Ree, R.; Willich, S. N.; Wahn, U.; Mills, E. N. C.; Beyer, K.

2010-01-01

P>Background/aim: The true prevalence and risk factors of food allergies in children are not known because estimates were based predominantly on subjective assessments and skin or serum tests of allergic sensitization to food. The diagnostic gold standard, a double-blind placebo-controlled food

Absent in melanoma 2 (AIM2) in rat dental pulp mediates the inflammatory response during pulpitis.

Science.gov (United States)

Wang, Yafei; Zhai, Shafei; Wang, Haijing; Jia, Qian; Jiang, Wenkai; Zhang, Xiao; Zhang, Ansheng; Liu, Jun; Ni, Longxing

2013-11-01

In recent years, the inflammasome has been determined to play an important role in inflammatory diseases. However, the role of the inflammasome in pulpitis remains unclear. Absent in melanoma 2 (AIM2) is a type of inflammasome that recognizes cytosolic double stranded DNA and forms a caspase-1-activating inflammasome with apoptosis-associated speck-like protein containing a caspase activating recruiting domain. In this study, we determined whether AIM2 was expressed in pulp cells and defined the role of AIM2 in the initiation of inflammation within the dental pulp. In the in vivo study, the right maxillary molars from male adult Sprague-Dawley rats (250-350 g) were exposed to the pulp. In the in vitro study, the pulp cells isolated from the mandibular incisors of the Sprague-Dawley rats (2 weeks) were conventionally cultured. Immunofluorescence staining was used to determine the expression and distribution of AIM2 in the rat dental pulp tissues and cells in the presence or absence of inflammatory stimulation. Western blotting and real-time polymerase chain reaction were performed to determine whether there was a correlation between AIM2 expression levels and inflammation both in vivo and in vitro. In healthy dental pulp tissues and cells, AIM2 was only detected in the odontoblast layer. Stimulation significantly increased AIM2 expression in both the dental pulp tissues and cultured cells. The mRNA and protein levels of AIM2 were significantly up-regulated in response to inflammatory stimulation in a dose-dependent manner. Moreover, we also found that AIM2 expression correlated with interleukin-1 levels. These results reveal a direct relationship between the AIM2 inflammasome and pulpitis. Our study demonstrates that AIM2 is expressed in dental pulp tissues and mediates the inflammatory response during pulpitis. Therapeutic interventions aimed at reducing AIM2 expression may be beneficial in the treatment of pulpitis. Copyright © 2013 American Association of

Organizational technologies for transforming care: measures and strategies for pursuit of IOM quality aims.

Science.gov (United States)

Gamm, Larry; Kash, Bita; Bolin, Jane

2007-01-01

Progress on the Institute of Medicine's (IOM's) 6 aims to bridge the "quality chasm" requires both measurement and the concerting of multiple organizational technologies. The basic thesis of this article is that rapid progress on the IOM's multiple aims calls for transformative change within and among healthcare organizations. The promise of a number of types of transformative approaches is closely linked to their ability to simultaneously build upon several organizational technologies: clinical, social, information, and administrative technologies. To encourage and advance such efforts, this article identifies illustrative measures of attainment of the IOM's 6 aims or targeted areas for improvement that reflect the contributions of the 4 organizational technologies. It discusses examples of relationships between the IOM aims and the organizational technologies considered. Finally, the article offers illustrations of the interplay of these organizational technologies and IOM aims-across an array of organizational innovations with transformative potential. Included among such innovations are information technology in the form of electronic medical records, computer-based physician order entry, and patient health records; organization-wide patient-centered cultural change such as Studer's Hardwiring Excellence; Six Sigma and Toyota Production Management/LEAN; major clinical technology change, for example, minimally invasive cardiac surgery and broader treatment innovations such as disease management.

Integrated assessment of biodiesel policies aimed at family farms in Brazil

NARCIS (Netherlands)

Belo Leite, Dal J.G.; Nunes Vieira da Silva, J.V.; Ittersum, van M.K.

2014-01-01

With many of the poor people in Brazil living in rural areas, local governments have intensified their efforts to design and implement effective policies that boost rural development. In 2004, a national program for production and use of biodiesel was launched aiming at increasing income among less

Open innovation for phenotypic drug discovery: The PD2 assay panel.

Science.gov (United States)

Lee, Jonathan A; Chu, Shaoyou; Willard, Francis S; Cox, Karen L; Sells Galvin, Rachelle J; Peery, Robert B; Oliver, Sarah E; Oler, Jennifer; Meredith, Tamika D; Heidler, Steven A; Gough, Wendy H; Husain, Saba; Palkowitz, Alan D; Moxham, Christopher M

2011-07-01

Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays interrogate multiple molecular targets and signaling pathways in a target "agnostic" fashion, which may reveal novel functions for well-studied proteins and discover new pathways of therapeutic value. Significantly, existing compound libraries may not have sufficient chemical diversity to fully leverage a phenotypic strategy. To address this issue, Eli Lilly and Company launched the Phenotypic Drug Discovery Initiative (PD(2)), a model of open innovation whereby external research groups can submit compounds for testing in a panel of Lilly phenotypic assays. This communication describes the statistical validation, operations, and initial screening results from the first PD(2) assay panel. Analysis of PD(2) submissions indicates that chemical diversity from open source collaborations complements internal sources. Screening results for the first 4691 compounds submitted to PD(2) have confirmed hit rates from 1.6% to 10%, with the majority of active compounds exhibiting acceptable potency and selectivity. Phenotypic lead generation strategies, in conjunction with novel chemical diversity obtained via open-source initiatives such as PD(2), may provide a means to identify compounds that modulate biology by novel mechanisms and expand the innovation potential of drug discovery.

Aligning emergency care with the triple aim: Opportunities and future directions after healthcare reform.

Science.gov (United States)

Agrawal, Shantanu; Conway, Patrick H

2014-09-01

The Triple Aim of better health, better care, and lower costs has become a fundamental framework for understanding the need for broad health care reform and describing health care value. While the framework is not specific to any clinical setting, this article focuses on the alignment between the framework and Emergency Department (ED) care. The paper explores where emergency care is naturally aligned with each Aim, as well as current barriers which must be addressed to meet the full vision of the Triple Aim. We propose a vision of EDs serving as a nexus for care coordination optimally consistent with the Triple Aim and the requirements for such a role. These requirements include: (1) substantial integration in coordinated care models; (2) development of reliable and actionable data on ED quality, population health, and cost outcomes; (3) specific initiatives to control and optimize ED utilization; and (4) payment models which preserve surge and disaster response capacity. Published by Elsevier Inc.

Aiming and clicking in young children's use of the computer mouse

NARCIS (Netherlands)

Donker, A.; Reitsma, P.

2007-01-01

The present study investigated the abilities of young children to aim and click with a computer mouse. Young children have not yet fully developed their motor skills and they are therefore more likely than adults to click next to targets on the computer screen. Because in educational software

Failed culture change aimed at more service provision: A test of three agentic factors

NARCIS (Netherlands)

Jorritsma, P.Y.; Wilderom, Celeste P.M.

2012-01-01

Purpose – Headquarters managers of a medium-sized manufacturing company initiated a culture change in five of their dispersed wholesale units. The aim was for more external service quality. This paper aims to report the results of a test of three hypotheses, shedding light on the behavior of the

[AIMS65 score validation for upper gastrointestinal bleeding in the National Hospital Cayetano Heredia].

Science.gov (United States)

Aguilar Sánchez, Víctor; Bravo Paredes, Eduar Alban; Pinto Valdivia, José Luis; Valenzuela Granados, Vanessa; Espinoza-Rios, Jorge Luis

2015-01-01

To validate the score AIMS65 in patients with upper gastrointestinal bleeding, in terms of mortality and rebleeding a 30-day event. Patients included were those with higher age to 18 years attending the Hospital Nacional Cayetano Heredia during the period May 2013 to December 2014, by upper gastrointestinal bleeding. Data were analyzed using ROC curve (Receiver Operating Characteristic) and the area was obtained under the curve (AUC) to properly qualify the score AIMS65. 209 patients were included, 66.03% were male, with an average age of 58.02 years. The mortality rate was 7.65%, the multiorgan failure the most common cause of death. Plus 3.82% of the patients had recurrent bleeding and 11% required a transfusion of more than 2 units of blood. When analyzing the ROC curve with AIMS65 and mortality score a value of 0.9122 is reported; identifying it as cutoff greater than or equal to 3 value in the score AIMS65 to discriminate patients at high risk of death, likewise the ROC curve was analyzed for recurrence of bleeding with a value of 0.6266 and the need to Transfusion of packed red blood cells over two a value of 0.7421. And it was determined the average hospital stay with a value of 4.8 days, however, no correlation was found with the score AIMS65. AIMS65 score is a good predictor of mortality, and is useful for predicting the need for transfusion of more than 2 globular packages. However it is not a good predictor for recurrence of bleeding, or hospital stay.

Interventions aimed at increasing research use in nursing: a systematic review

Directory of Open Access Journals (Sweden)

Moore Katherine

2007-05-01

Full Text Available Abstract Background There has been considerable interest recently in developing and evaluating interventions to increase research use by clinicians. However, most work has focused on medical practices; and nursing is not well represented in existing systematic reviews. The purpose of this article is to report findings from a systematic review of interventions aimed at increasing research use in nursing. Objective To assess the evidence on interventions aimed at increasing research use in nursing. Methods A systematic review of research use in nursing was conducted using databases (Medline, CINAHL, Healthstar, ERIC, Cochrane Central Register of Controlled Trials, and Psychinfo, grey literature, ancestry searching (Cochrane Database of Systematic Reviews, key informants, and manual searching of journals. Randomized controlled trials and controlled before- and after-studies were included if they included nurses, if the intervention was explicitly aimed at increasing research use or evidence-based practice, and if there was an explicit outcome to research use. Methodological quality was assessed using pre-existing tools. Data on interventions and outcomes were extracted and categorized using a pre-established taxonomy. Results Over 8,000 titles were screened. Three randomized controlled trials and one controlled before- and after-study met the inclusion criteria. The methodological quality of included studies was generally low. Three investigators evaluated single interventions. The most common intervention was education. Investigators measured research use using a combination of surveys (three studies and compliance with guidelines (one study. Researcher-led educational meetings were ineffective in two studies. Educational meetings led by a local opinion leader (one study and the formation of multidisciplinary committees (one study were both effective at increasing research use. Conclusion Little is known about how to increase research use in

The reliability of manual reporting of clinical events in an anesthesia information management system (AIMS).

Science.gov (United States)

Simpao, Allan F; Pruitt, Eric Y; Cook-Sather, Scott D; Gurnaney, Harshad G; Rehman, Mohamed A

2012-12-01

Manual incident reports significantly under-report adverse clinical events when compared with automated recordings of intraoperative data. Our goal was to determine the reliability of AIMS and CQI reports of adverse clinical events that had been witnessed and recorded by research assistants. The AIMS and CQI records of 995 patients aged 2-12 years were analyzed to determine if anesthesia providers had properly documented the emesis events that were observed and recorded by research assistants who were present in the operating room at the time of induction. Research assistants recorded eight cases of emesis during induction that were confirmed with the attending anesthesiologist at the time of induction. AIMS yielded a sensitivity of 38 % (95 % confidence interval [CI] 8.5-75.5 %), while the sensitivity of CQI reporting was 13 % (95 % CI 0.3-52.7 %). The low sensitivities of the AIMS and CQI reports suggest that user-reported AIMS and CQI data do not reliably include significant clinical events.

Proosa 1977. Kirjanduse argipäev / Mall Jõgi

Index Scriptorium Estoniae

Jõgi, Mall, 1947-

2008-01-01

Sisaldab joonealuseid märkusi ja bibliograafiat. - Varem ilmunud Looming 1978, nr. 2. - Ülevaade 1977. aastal ilmunud eesti proosast. Käsitletakse järgmisi autoreid ja nende teoseid: Ustav Mikelsaar "Ohver", Lembit Kivisaar "Vana diivan", Albert Uustulnd "Avali väraval", Asta Põldmäe "Me", Lilli Promet "Tüdrukud taevast", Nikolai Baturin "Leiud kajast", Aadu Hint "Oma saar", Paul Kuusberg "Linnukesega", Aimée Beekman "Sugupuu", Mari Saat "Mida teha emaga?", Veera Saar "Isa niinepuu", Villem Gross "Vaikimise motiivid", Jüri Tuulik "Meretagune asi", Aira Kaal "Teedla Riia aknas põleb tuli", Tõnis Lehtmets "Tume laas", Väino Ilus "Kinsli peremehed", Einar Maasik "Hispaania tants", Aino Müür "Linnuvere lugu", Jaan Kross "Kolme katku vahel" 3. osa, Endel Nirk "Kaanekukk", Paul Kuusberg "Võõras või õige mees", Toomas Vint "Perekondlikud mängud", Ine Viiding "Kümme käsku kaaskodanikele", Mats Traat "Irdinimene. Türgi oad", Teet Kallas "Õhtuvalgus", Teet Kallas "Insener Paberiti juhtum", Einar Maasik "Üksinda detsembris", Enn Vetemaa "Hõbedaketrajad", Herta Laipaik "Kummitus muusikatoas. Doktor Vallaku mõistatus", Raimond Kaugver "Külalisteraamat"

The method of quick satellite aiming with 3-Steps on the mobile satellite station

Directory of Open Access Journals (Sweden)

Sheng Liang

2017-02-01

Full Text Available The study analyses and concludes the technology of the satellite aiming during real-time broadcast of mobile video.We conclude a method of quick satellite aiming with 3-steps according to practical exercises and users' requirement to meet situation of facts and standardized operation,which can improve efficiency and quality of service.

Students' Performance in Investigative Activity and Their Understanding of Activity Aims

Science.gov (United States)

Gomes, Alessandro Damasio Trani; Borges, A. Tarciso; Justi, Rosaria

2008-01-01

This study investigates the relationship between the students' understanding of the aims of an investigative activity and their performance when conducting it. One hundred and eighty-one year nine students from a public middle school in Brazil took part in the study. Students working in pairs were asked to investigate two problems using a…

RAINWATER MANAGEMENT AIMING TO IMPROVE THE QUALITY OF URBAN SURFACE RUNOFF

Directory of Open Access Journals (Sweden)

I. HAIDU

2015-10-01

Full Text Available Rainwater Management Aiming to Improve the Quality of Urban Surface Runoff. Currently many urban areas experience the quality degradation of rooftop runoff and accumulated rainwater. The present study aims to estimate the volume of water draining from rooftops within an area of 0.68 km² in the municipality of Cluj-Napoca. The volume of water flowing from rooftops presents a beneficial alternative not only for collecting rainwater for later use, but also for reducing the volume of water and for improving surface runoff quality in urban areas. The procedure was based on the Michel Simplified SCS-CN model, a derived variant of the most popular hydrological model, the Soil Conservation Service Curve Number (SCS-CN. The results of the applied method reveal that the highest rooftop runoff water values correspond to the summer months, these being based on daily rainfall data. Estimating the volume of water draining from rooftops for future harvesting is an important step in the sustainable management of rainwater in urban areas and in improving water quality.

Advanced Integrated Multi-Sensor Surveillance (AIMS. Operator Machine Interface (OMI) Definition Study

National Research Council Canada - National Science Library

Baker, Kevin; Youngson, Gord

2007-01-01

To enhance the capability of airborne search and rescue (SAR) and surveillance, particularly at night and in poor weather, a multi sensor electro optical imaging system, the Advanced Integrated Multi sensor Surveillance (AIMS...

Evaluation of Heliostat Standby Aiming Strategies to Reduce Avian Flux Hazards and Impacts on Operational Performance

Energy Technology Data Exchange (ETDEWEB)

Wendelin, Timothy J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ho, Clifford K. [Sandia National Laboratories; Horstman, Luke [Sandia National Laboratories

2017-06-03

This paper presents a study of alternative heliostat standby aiming strategies and their impact on avian flux hazards and operational performance of a concentrating solar power plant. A mathematical model was developed that predicts the bird-feather temperature as a function of solar irradiance, thermal emittance, convection, and thermal properties of the feather. The irradiance distribution in the airspace above the Ivanpah Unit 2 heliostat field was simulated using a ray-trace model for two different times of the day, four days of the year, and nine different standby aiming strategies. The impact of the alternative aiming strategies on operational performance was assessed by comparing the heliostat slew times from standby position to the receiver for the different aiming strategies. Increased slew times increased a proxy start-up time that reduced the simulated annual energy production. Results showed that spreading the radial aim points around the receiver to a distance of ~150 m or greater reduced the hazardous exposure times that the feather temperature exceeded the hazard metric of 160 degrees C. The hazardous exposure times were reduced by ~23% and 90% at a radial spread of aim points extending to 150 m and 250 m, respectively, but the simulated annual energy production decreased as a result of increased slew times. Single point-focus aiming strategies were also evaluated, but these strategies increased the exposure hazard relative to other aiming strategies.

Midline body actions and leftward spatial Aiming in patients with spatial neglect

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Amit eChaudhari

2015-07-01

Full Text Available Spatial motor-intentional Aiming bias is a dysfunction in initiation/execution of motor intentional behavior, resulting in hypokinetic and hypometric leftward movements. Aiming bias may contribute to posture, balance and movement problems and uniquely account for disability in post-stroke spatial neglect. Body movement may modify and even worsen Aiming errors, but therapy techniques such as visual scanning training do not take this into account. Here, we evaluated 1 whether instructing neglect patients to move midline body parts improves their ability to explore left space, and 2 whether this has a different impact on different patients. A 68-year-old woman with spatial neglect after a right basal ganglia infarct had difficulty orienting to and identifying left-sided objects. She was prompted with four instructions: look to the left, point with your nose to the left, point with your [right] hand to the left, and stick out your tongue and point it to the left. She oriented leftward dramatically better when pointing with the tongue/nose, than she did when pointing with the hand. We then tested 9 more consecutive patients with spatial neglect using the same instructions. Only four of them made any orienting errors. Only one patient made >50% errors when pointing with the hand, and she did not benefit from pointing with the tongue/nose. We observed that pointing with the tongue could facilitate left-sided orientation in a stroke survivor with spatial neglect. If midline structures are represented more bilaterally, they may be less affected by Aiming bias. Alternatively, moving the body midline may be more permissive for leftward orienting than moving right body parts. We were not able to replicate this effect in another patient; we suspect that the magnitude of this effect may depend upon the degree to which patients have directional akinesia, spatial Where deficits, or cerebellar/frontal cortical lesions. Future research could examine these

A Core Design Approach Aimed at Sustainability and Intrinsic Safety

International Nuclear Information System (INIS)

Grasso, Giacomo

2013-01-01

The comprehensive approach adopted for the core design of all LFRs investigated within the LEADER project, proved to effectively drive the design to the fulfillment of the aimed sustainability performances, and the respect of the design constraints for the robust implementation of the inherent safety principle: • the ELFR core is able to operate adiabatically, with a very narrow reactivity swing along a 2.5 y cycle; • wide margins are provided for protecting the fuel and the structures even in case of unprotected transients, allowing for very long grace times

[Social marketing--seduction with the aim of healthy behavior?].

Science.gov (United States)

Loss, J; Nagel, E

2010-01-01

SOCIAL MARKETING - SEDUCTION WITH THE AIM OF HEALTHY BEHAVIOR? Social marketing is the use of marketing principles to design and implement programs that promote socially beneficial behaviour change. Contrary to the marketing of consumption goods, social marketing does not deal with material products, but with behaviour, e. g. not smoking. This 'product' has a basic benefit (i. e. reduction of health risks in the long run), which is, however, difficult to convey. Therefore, the intended change in behaviour has to be related to a further reward which consists of symbolic goods, e. g. social appreciation or a better body feeling. The communication policy is essential for information on and motivation for the preventive issue. Social marketing campaigns whose development and management follow the principles of classical marketing can render preventive efforts more effective. In addition, social marketing can lead to a better quality management as compared to conventional preventive activities. These advantages can be explained by a) tailoring the campaign more specifically to the target group's needs and motives, b) presenting health risks more convincingly, and c) continuously analysing and evaluating the campaign and its effects. On the other hand, the marketing of preventive aims through mass media can bear several risks, as exemplified by different national and international public health campaigns. The necessity to communicate briefly and succinctly can lead to misleading simplifications and, in case of cancer screening, to the trivialization of a behaviour's consequences and adverse effects. Also, many campaigns do not intend to educate and inform, but try to persuade target persons of a certain behaviour, using emotions such as fear. This has led to social marketing being criticized as manipulation. Sometimes, social marketing campaigns cause stigma and discrimination of certain population subgroups, e. g. obese or HIV-positive people. Health promoters who plan

Soil treatment technologies: Comparison of field experiences

International Nuclear Information System (INIS)

Hodges, H.I.; Jackson, D.W.; Kline, K.

1992-01-01

A number of on-site soil treatment technologies are available for closure of oil-field waste pits, leaking underground storage tank (LUST) sites, and general hydrocarbon contamination. This paper will contrast Separation Systems Consultants, Inc.'s (SSCI's) field experiences with the following soil restoration techniques: (1) Land Treatment using indigenous microbes; (2) Land Farming using commercial microbes; (3) Low Temperature Thermal Treatment; (4) Solidification. The technologies will be contrasted in terms of regulatory constraints and requirements, key set-up and maintenance consideration, selection factors. Included in the regulatory contrast is the authors' perception of regulatory attitudes toward the techniques. Because this paper is based on actual field experience and projects, the practical aspects of making the technologies work is emphasized

Ludmilla Siim : Distantseeritud urbanismi lavastaja = Staged distanced urbanism / Kädi Talvoja

Index Scriptorium Estoniae

Talvoja, Kädi, 1974-

2007-01-01

Ludmilla Siim (nüüd Milla Siim-Kaasinen) on eesti kunstiajalukku jäänud kui lootustandev ja samas ka lõpuni realiseerimata jäänud andega maalija, kelle loomingut on käsitletud kui sissejuhatust eesti hüperrealismi diskursusesse. 1977. aastal kolis ta Soome elama ja pälvis meil riigireeturi staatuse, mille järel tema nimi kustutati avalikust kultuurimälust. Soomes kohanes ta sealsete kunstikaanonitega, loobudes oma senisest tunnetuslikust maalimislaadist ja industriaalse keskkonna temaatikast abstraktsionismi kasuks. Kuigi Siimu loomingu keskteljeks on urbanistlik keskkond, mis annab töödele ajastuspetsiifilise aura, on reeglina tegu siiski tema imaginaarsete visioonidega, keskendudes ruumi rollile inimestevahelistes suhetes, mis üles ehitatud kontrastidele, koloriit tavaliselt popilikult kirgas ja intensiivne

A Triple Aim Framework For the Performance Assessment of Disease Management Programs

NARCIS (Netherlands)

Verbeek, N.A.; M.G. Franken (Margreet); M.A. Koopmanschap (Marc); M.P.M.H. Rutten-van Mölken (Maureen)

2015-01-01

markdownabstractObjectives: A structured and comprehensive assessment of disease management implementations is not straightforward due to the broadness of the interventions and the various evaluation possibilities. The aim of this study was to develop a comprehensive framework for outcome

Association between pain severity, depression severity, and use of health care services in Japan: results of a nationwide survey

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Vietri J

2015-03-01

Full Text Available Jeffrey Vietri,1 Tempei Otsubo,2 William Montgomery,3 Toshinaga Tsuji,4 Eiji Harada5 1Health Outcomes Practice, Kantar Health, Milan, Italy; 2Tokyo Shinjuku Medical Center, Tokyo, Japan; 3Eli Lilly Australia Pty Ltd., West Ryde, Australia; 4Medical Affairs, Shionogi & Co., Ltd., Osaka, Japan; 5Eli Lilly Japan KK, Kobe, Japan Background: Depression is often associated with painful physical symptoms. Previous research has seldom assessed the relationship between the severity of physical symptoms and the severity of mental and emotional symptoms of depression or other health outcomes, and no such studies have been conducted previously among individuals with depression in Japan. The aim of this study was to assess the relationship between the severity of physical pain and depression and other outcomes among individuals in Japan diagnosed with depression.Methods: Data for individuals aged 18 and older in Japan who reported being diagnosed with depression and also reported physical pain were obtained from the Japan National Health and Wellness Survey. These respondents were characterized on sociodemographics and health characteristics, and the relationship between ratings of severity on pain in the last week and health outcomes were assessed using bivariate correlations and generalized linear models. Measures included the Patient Health Questionnaire for depression severity, Medical Outcomes Study 12-Item Short Form Survey Instrument for health-related quality of life, the Work Productivity and Activity Impairment for work and activity impairment, and 6-month report of health care use.Results: More severe physical pain in the past week was correlated with more severe depression, worse health-related quality of life, lower health utility, greater impairment at work, and more health care provider visits. These relationships remained significant after incorporating sociodemographics and health characteristics in the statistical models

Jutuvõistluse "Musta mantliga mees" võitis Katrin Johanson

Index Scriptorium Estoniae

2007-01-01

Eduard Vilde muuseumi poolt läbi viidud krimi- ja põnevusjuttude võistlusest "Musta mantliga mees". Žürii: Karl Martin Sinijärv, Juhan Habicht, Paul Pajos, Rebekka Lotman, Kristin Rammus, Piret Meos.Võitja: Katrin Johanson, teine koht: Taavet Kase, kolmas koht: Imre Kõuts. Ajalehe "Postimees" eriauhinnad said: Juhan Voolaid, Hella Riisalu, Stina Maria Vilt, Sirle Poikkanen, Märt Kivimäe. Tallinna noorte infokeskuse auhinnad: Juhan Voolaid, Sirle Poikkalainen, Lilli Anderson, Aino Rätsep. Eduard Vilde muuseumi eriauhinnad: Merilin Jürjo, Laura Pirso

Experimental validation of large-eddy simulation for swirling methane-air non-premixed combustion

Energy Technology Data Exchange (ETDEWEB)

Hu, L.Y.; Luo, Y.H.; Xu, C.S. [Shanghai Jiaotong Univ. (China). School of Mechanical Engineering; Zhou, L.X. [Tsinghua Univ., Beijing (China). Dept. of Engineering Mechanics

2013-07-01

Large-eddy simulation of swirling methane-air non-premixed combustion was carried out using a Smagorinsky-Lilly subgrid scale stress model and a presumed-PDF fast-chemistry combustion model. The LES statistical results are validated by PIV, temperature and species concentration measurements made by the present authors. The results indicate that in the present case the presumed-PDF fast-chemistry combustion model is a fairish one. The instantaneous vorticity and temperature maps show clearly the development and the interaction between coherent structures and combustion.

The Ambulatory Integration of the Medical and Social (AIMS) model: A retrospective evaluation.

Science.gov (United States)

Rowe, Jeannine M; Rizzo, Victoria M; Shier Kricke, Gayle; Krajci, Kate; Rodriguez-Morales, Grisel; Newman, Michelle; Golden, Robyn

2016-01-01

An exploratory, retrospective evaluation of Ambulatory Integration of the Medical and Social (AIMS), a care coordination model designed to integrate medical and non-medical needs of patients and delivered exclusively by social workers was conducted to examine mean utilization of costly health care services for older adult patients. Results reveal mean utilization of 30-day hospital readmissions, emergency department (ED) visits, and hospital admissions are significantly lower for the study sample compared to the larger patient population. Comparisons with national population statistics reveal significantly lower mean utilization of 30-day admissions and ED visits for the study sample. The findings offer preliminary support regarding the value of AIMS.

Visual Distraction: An Altered Aiming Spatial Response in Dementia

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Elizabeth E. Galletta

2012-06-01

Full Text Available Background/Aims: Healthy individuals demonstrate leftward bias on visuospatial tasks such as line bisection, which has been attributed to right brain dominance. We investigated whether this asymmetry occurred in patients with probable dementia of the Alzheimer type (pAD which is associated with neurodegenerative changes affecting temporoparietal regions. Methods: Subjects with pAD and matched controls performed a line bisection task in near and far space under conditions of no distraction, left-sided visual distraction and right-sided visual distraction. Results: Participants with pAD manifested different motor-preparatory ‘aiming’ spatial bias than matched controls. There were significantly greater rightward ‘aiming’ motor-intentional errors both without distraction and with right-sided distraction. Conclusion: ‘Aiming’ motor-preparatory brain activity may be induced by distraction in pAD subjects as compared to typical visual-motor function in controls.

Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

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Satoko Arai

2013-04-01

Full Text Available Natural immunoglobulin M (IgM is reactive to autoantigens and is believed to be important for autoimmunity. Blood pentameric IgM loaded with antigens forms a large immune complex (IC that contains various elements, including apoptosis inhibitor of macrophage (AIM. Here we demonstrate that this IgM-AIM association contributes to autoantibody production under obese conditions. In mice fed a high-fat diet, natural IgM increased through B cell TLR4 stimulation. AIM associated with IgM and protected AIM from renal excretion, increasing blood AIM levels along with the obesity-induced IgM augmentation. Meanwhile, the AIM association inhibited IgM binding to the Fcα/μ receptor on splenic follicular dendritic cells, thereby protecting the IgM IC from Fcα/μ receptor-mediated internalization. This supported IgM-dependent autoantigen presentation to B cells, stimulating IgG autoantibody production. Accordingly, in obese AIM-deficient (AIM−/− mice, the increase of multiple IgG autoantibodies observed in obese wild-type mice was abrogated. Thus, the AIM-IgM association plays a critical role in the obesity-associated autoimmune process.

Hilar cholangiocarcinoma: controversies on the extent of surgical resection aiming at cure.

Science.gov (United States)

Xiang, Shuai; Lau, Wan Yee; Chen, Xiao-ping

2015-02-01

Hilar cholangiocarcinoma is the most common malignant tumor affecting the extrahepatic bile duct. Surgical treatment offers the only possibility of cure, and it requires removal of all tumoral tissues with adequate resection margins. The aims of this review are to summarize the findings and to discuss the controversies on the extent of surgical resection aiming at cure for hilar cholangiocarcinoma. The English medical literatures on hilar cholangiocarcinoma were studied to review on the relevance of adequate resection margins, routine caudate lobe resection, extent of liver resection, and combined vascular resection on perioperative and long-term survival outcomes of patients with resectable hilar cholangiocarcinoma. Complete resection of tumor represents the most important prognostic factor of long-term survival for hilar cholangiocarcinoma. The primary aim of surgery is to achieve R0 resection. When R1 resection is shown intraoperatively, further resection is recommended. Combined hepatic resection is now generally accepted as a standard procedure even for Bismuth type I/II tumors. Routine caudate lobe resection is also advocated for cure. The extent of hepatic resection remains controversial. Most surgeons recommend major hepatic resection. However, minor hepatic resection has also been advocated in most patients. The decision to carry out right- or left-sided hepatectomy is made according to the predominant site of the lesion. Portal vein resection should be considered when its involvement by tumor is suspected. The curative treatment of hilar cholangiocarcinoma remains challenging. Advances in hepatobiliary techniques have improved the perioperative and long-term survival outcomes of this tumor.

Internet Use with Learning Aim: Views of German Language Pre-Service Teachers

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Mukadder Seyhan Yücel

2011-10-01

Full Text Available The aim of this study is to indicate the views of teacher candidates of German Language Department at Education Faculty, Trakya University about the use of internet with the aim of learning. This study has designed as phenomenology which is one of the qualitative research methods. The study data were obtained via semi-constructed interview technique and the content analysis technique was used in the data analysis. In the research, the findings gathered from the interviews with the teacher candidates are presented in themes, and then interpreted. Considering findings of the study, it has been seen that Internet should be used for learning-teaching purpose. Teacher candidates of German Language support the fact that Internet has a crucial role in education, and particularly it is useful and essential as Internet provides lots of opportunities for German Language Teaching such as authentic study samples, rich materials and exercises on skills, contemporary videos reflecting German culture or film sections. Internet is also a good material which provides accessing various information and also realizing and sharing many goals. If the information is gathered via audio and visual ways, it will be retentive. Thus, German Language teacher candidates can have opportunity to study on the foreign language and its culture through Internet. Furthermore, they have met the contemporary approaches like realizing self-directed learning individually. That’s why, the views of German Language pre-service teacher about the use of Internet with the aim of learning are very important.

Internet Use with Learning Aim: Views of German Language Pre-Service Teachers

Directory of Open Access Journals (Sweden)

Mukadder Seyhan Yücel

2011-04-01

Full Text Available The aim of this study is to indicate the views of teacher candidates of German Language Department at Education Faculty, Trakya University about the use of internet with the aim of learning. This study has designed as phenomenology which is one of the qualitative research methods. The study data were obtained via semi-constructed interview technique and the content analysis technique was used in the data analysis. In the research, the findings gathered from the interviews with the teacher candidates are presented in themes, and then interpreted. Considering findings of the study, it has been seen that Internet should be used for learning-teaching purpose. Teacher candidates of German Language support the fact that Internet has a crucial role in education, and particularly it is useful and essential as Internet provides lots of opportunities for German Language Teaching such as authentic study samples, rich materials and exercises on skills, contemporary videos reflecting German culture or Şlm sections. Internet is also a good material which provides accessing various information and also realizing and sharing many goals. If the information is gathered via audio and visual ways, it will be retentive. Thus, German Language teacher candidates can have opportunity to study on the foreign language and its culture through Internet. Furthermore, they have met the contemporary approaches like realizing self-directed learning individually. That’s why, the views of German Language pre-service teacher about the use of Internet with the aim of learning are very important

Introduction of management accounting in the company: aims, goals and stages

Directory of Open Access Journals (Sweden)

Duishenalieva A.M.

2017-01-01

Full Text Available the author of this article considers the main aims and goals of management accounting introduction. The main features of introduction are described. The main stages of introduction of management accounting are presented and each stage is analyzed in detail. An effective introduction and implementation of management accounting is impossible without indicating responsibility centers. In this regard, the main responsibility centers have been identified and described.

What's the Deal with Methane at LUST Spill Sites? Part 2: Vapor Intrusion

Science.gov (United States)

This article is specifically intended to discuss methane produced from releases of ethanol and gasoline-ethanol mixtures. There may be other sources of methane at a site, including leaks of natural gas or methane produced from the natural decay of buried plant tissues or from the...

Kroonika esitleb : Justin Timberlake ja Rod Stewart / Justin Timberlake ; interv. Katrin Lust-Buchanan

Index Scriptorium Estoniae

Timberlake, Justin

2006-01-01

Meesteajakirja GQ auhindade jagamise tseremoonial Londonis sai ajakirja Kroonika reporter jutule aasta rahvusvahelisima mehe tiitli pälvinud Justin Timberlake'i ja elutööpreemia saanud Rod Stewartiga

Alginate Immobilization of Metabolic Enzymes (AIME) for High-Throughput Screening Assays (SOT)

Science.gov (United States)

Alginate Immobilization of Metabolic Enzymes (AIME) for High-Throughput Screening Assays DE DeGroot, RS Thomas, and SO SimmonsNational Center for Computational Toxicology, US EPA, Research Triangle Park, NC USAThe EPA’s ToxCast program utilizes a wide variety of high-throughput s...

RE-AIM Checklist for Integrating and Sustaining Tier 2 Social-Behavioral Interventions

Science.gov (United States)

Cheney, Douglas A.; Yong, Minglee

2014-01-01

Even though evidence-based Tier 2 programs are now more commonly available, integrating and sustaining these interventions in schools remain challenging. RE-AIM, which stands for Reach, Effectiveness, Adoption, Implementation, and Maintenance, is a public health framework used to maximize the effectiveness of health promotion programs in…

Assessment of direct analgesic effect of duloxetine for chronic low back pain: post hoc path analysis of double-blind, placebo-controlled studies

Directory of Open Access Journals (Sweden)

Enomoto H

2017-06-01

Full Text Available Hiroyuki Enomoto,1 Shinji Fujikoshi,2 Jumpei Funai,3 Nao Sasaki,4 Michael H Ossipov,5 Toshinaga Tsuji,6 Levent Alev,7 Takahiro Ushida8 1Medical Science, Eli Lilly Japan K.K., Tokyo, 2Statistical Science, 3Science Communications, 4Medical Science, Eli Lilly Japan K.K., Kobe, Japan; 5Clinical Division, inVentiv Health, LLC, Blue Bell, PA, USA; 6Medical Affairs Department, Shionogi & Co., Ltd., Osaka, Japan; 7Medical Department, Lilly Turkey, Istanbul, Turkey; 8Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Aichi, Japan Background: Comorbid depression and depressive symptoms are common in patients with chronic low back pain (CLBP. Duloxetine is clinically effective in major depressive disorder and several chronic pain states, including CLBP. The objective of this post hoc meta-analysis was to assess direct and indirect analgesic efficacy of duloxetine for patients with CLBP in previous clinical trials. Methods: Post hoc path analyses were conducted of 3 randomized, double-blind, clinical studies of patients receiving duloxetine or placebo for CLBP. The primary outcome measure for pain was the Brief Pain Inventory, average pain score. A secondary outcome measure, the Beck Depression Inventory-II, was used for depressive symptoms. The changes in score from baseline to endpoint were determined for each index. Path analyses were employed to calculate the proportion of analgesia that may be attributed to a direct effect of duloxetine on pain.Results: A total of 851 patients (400 duloxetine and 451 placebo were included in this analysis. Duloxetine significantly improved pain scores compared with placebo (p<0.001. It also significantly improved depressive scores compared with placebo (p=0.015. Path analyses showed that 91.1% of the analgesic effect of duloxetine could be attributed to a direct analgesic effect, and 8.9% to its antidepressant effect. Similar results were obtained when data were evaluated at weeks 4 and 7, and when

Clinical course of nonalcoholic fatty liver disease: an assessment of severity, progression, and outcomes

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Simeone JC

2017-12-01

Full Text Available Jason C Simeone,1 Jay P Bae,2 Byron J Hoogwerf,3 Qian Li,1 Axel Haupt,3 Ayad K Ali,4 Marilyn K Boardman,3 Beth L Nordstrom1 1Real-world Evidence, Evidera, Waltham, MA, USA; 2Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Indianapolis, IN, USA; 3Lily Diabetes, Eli Lilly and Company, Indianapolis, IN, USA; 4Global Patient Safety, Eli Lilly and Company, Indianapolis, IN, USA Purpose: To identify the characteristics and initial disease severity of patients with nonalcoholic fatty liver disease (NAFLD and assess incidence and risk factors for disease progression in a retrospective study.Methods: Patients ≥18 years of age without alcoholism or other liver diseases (eg, hepatitis B/C were selected from Geisinger Health System electronic medical record data from 2004 to 2015. Initial disease stage was stratified into uncomplicated NAFLD, advanced fibrosis, cirrhosis, hepatocellular carcinoma (HCC, and liver transplant using clinical biomarkers, diagnosis, and procedure codes. Disease progression was defined as stage progression or death and analyzed via Kaplan–Meier plots and multistate models.Results: In the NAFLD cohort (N=18,754, 61.5% were women, 39.0% had type 2 diabetes mellitus (T2DM, and the mean body mass index was 38.2±10.2 kg/m2. At index, 69.9% had uncomplicated NAFLD, 11.7% had advanced fibrosis, and 17.8% had cirrhosis. Of 18,718 patients assessed for progression, 17.3% progressed (11.0% had stage progression, 6.3% died without evidence of stage progression during follow-up (median=842 days. Among subgroups, 12.3% of those without diabetes mellitus progressed vs 24.7% of those with T2DM. One-year mortality increased from 0.5% in uncomplicated NAFLD to 22.7% in HCC. After liver transplant, mortality decreased to 5.6% per year.Conclusions: In 2.3 years of follow-up, approximately 17% of patients progressed or died without evidence of stage progression. T2DM was associated with approximately twice the risk of

Health care costs before and after diagnosis of depression in patients with unexplained pain: a retrospective cohort study using the United Kingdom General Practice Research Database

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Reed C

2013-01-01

Full Text Available Catherine Reed,1 Jihyung Hong,2 Diego Novick,1 Alan Lenox-Smith,3 Michael Happich41Global Health Outcomes, Eli Lilly and Company, Windlesham, Surrey, UK; 2Personal Social Services Research Unit, London School of Economics and Political Science, London, UK; 3Eli Lilly UK, Basingstoke, UK; 4Eli Lilly and Company, Bad Homburg, GermanyPurpose: To assess the impact of pain severity and time to diagnosis of depression on health care costs for primary care patients with pre-existing unexplained pain symptoms who subsequently received a diagnosis of depression.Patients and methods: This retrospective cohort study analyzed 4000 adults with unexplained pain (defined as painful physical symptoms [PPS] without any probable organic cause and a subsequent diagnosis of depression, identified from the UK General Practice Research Database using diagnostic codes. Patients were categorized into four groups based on pain severity (milder or more severe; based on number of pain-relief medications and use of opioids and time to diagnosis of depression (≤1 year or >1 year from PPS index date. Annual health care costs were calculated (2009 values and included general practitioner (GP consultations, secondary care referrals, and prescriptions for pain-relief medications for the 12 months before depression diagnosis and in the subsequent 2 years. Multivariate models of cost included time period as a main independent variable, and adjusted for age, gender, and comorbidities.Results: Total annual health care costs before and after depression diagnosis for the four patient groups were higher for the groups with more severe pain (£819–£988 versus £565–£628; P < 0.001 for all pairwise comparisons and highest for the group with more severe pain and longer time to depression diagnosis in the subsequent 2 years (P < 0.05. Total GP costs were highest in the group with more severe pain and longer time to depression diagnosis both before and after depression diagnosis (P

Advanced Industrial Materials (AIM) Program. Annual progress report, FY 1994

Energy Technology Data Exchange (ETDEWEB)

Sorrell, C.A.

1995-05-01

The Advanced Industrial Materials Program is a part of the Office of Industrial Technologies (OIT), Energy Efficiency and Renewable Energy in the Department of Energy. The mission of the AIM Program is to conduct applied research, development, and applications engineering work, in partnership with industry, to commercialize new or improved materials and materials processing methods that will improve energy efficiency, productivity, and competitiveness. AIM is responsible for identifying, supporting, and coordinating multidisciplinary projects to solve identified industrial needs and transferring the technology to the industrial sector. Program investigators in the DOE National Laboratories are working closely with approximately 100 companies, including 15 partners in Cooperative Research and Development Agreements. Work is being done in a wide variety of materials technologies, including intermetallic alloys, ceramic composites, metal composites, polymers, engineered porous materials, and surface modification. The Program supports other efforts in the Office of Industrial Technologies to assist the energy consuming process industries, including forest products, glass, steel, aluminum, foundries, chemicals, and refineries. To support OITs {open_quotes}Industries of the Future{close_quotes} initiatives and to improve the relevance of materials research, assessments of materials needs and opportunities in the process industries are being made. These assessments are being used for program planning and priority setting; support of work to satisfy those needs is being provided. Many new materials that have come into the marketplace in recent years, or that will be available for commercial use within a few more years, offer substantial benefits to society. This document contains 28 reports on advanced materials research. Individual reports have been processed separately for entry onto the Department of Energy databases.

The real aims of the USA and the EU in the Balkans

Directory of Open Access Journals (Sweden)

Čavoški Kosta S.

2002-01-01

Full Text Available The article explores the real aims of the so-called international community which is usually understood as the USA, as the only remaining super power and the European Union, particularly France. Great Britain and Germany. The author argues that the real and particularly long-term aims of these powers should be primarily inferred from their real deeds and only subsequently from public statements of their officials. By analyzing a number of examples in the Balkans and in other parts of the world the author comes to unexpected conclusions. While in words big Western powers supported multi-ethnicity and preservation of multi-ethnic states, in deeds they not only instigated nationalism and separatism but also hastened and recognized the dissolution of three European federations into 22 more or less national states. And while in words they apparently supported so-called democratization, in practice they not only supported authoritarian regimes but also identified democracy with occupation in Republika Srpska.

Motivation, procedures and aims of reacting plasma experiments

International Nuclear Information System (INIS)

Miyahara, Akira

1982-01-01

A project of reacting plasma experiment (R-project) was proposed at the Institute of Plasma Physics (IPP), Nagoya University. It is necessary to bridge plasma physics and fusion engineering by means of a messenger wire like burning plasma experiment. This is a motivation of the R-project. The university linkage organization of Japan for fusion engineering category carried out a lot of contribution to R-tokamak design. The project consists of four items, namely, R-tokamak design, research and development (R and D), site and facilities, and international collaboration. The phase 1 experiment (R 1 - phase) corresponds to burning plasma experiment without D + T fuel, while the phase-2 experiment (R 2 -phase) with D + T fuel. One reference design was finished. Intensive efforts have been carried out by the R and D team on the following items, wall material, vacuum system, tritium system, neutronics, remote control system, pulsed superconducting magnet development, negative ion source, and alpha-particle diagnostics. The problems concerning site and major facilities are also important, because tritium handling, neutron and gamma-ray sky shines and the activation of devices cause impact to surrounding area. The aims of burning plasma experiment are to enter tritium into the fusion device, and to study burning plasma physics. (Kato, T.)

Acid activation of natural clays aiming their application in adsorption

International Nuclear Information System (INIS)

Silva, M.M. da; Sousa, A.K.F. de; Lima, W.S.; Vasconcelos, P.N.M. de; Rodrigues, M. G.F.

2012-01-01

Clays of smectite type have wide application in industrial, mainly due to their adsorption properties. However, it is necessary to subject them to chemical treatments to optimize their potential. This study aimed to analyze the effects of acid activation on the clay Brasgel fresh. In the acid activation was used concentrated hydrochloric acid at different concentrations (3M, 4.5 M and 6 M) at a temperature of 70 ° C for 30 minutes. The samples fresh and activated technique were characterized by X-ray Diffraction (XRD). The results show that the properties of clay after activation are improved, it could be used as adsorbents in the treatment of wastewater. (author)

Root cause investigation of a viral contamination incident occurred during master cell bank (MCB) testing and characterization--a case study.

Science.gov (United States)

Chen, Dayue; Nims, Raymond; Dusing, Sandra; Miller, Pamela; Luo, Wen; Quertinmont, Michelle; Parekh, Bhavin; Poorbaugh, Josh; Boose, Jeri Ann; Atkinson, E Morrey

2008-11-01

An adventitious agent contamination occurred during a routine 9 CFR bovine viral screening test at BioReliance for an Eli Lilly Chinese Hamster Ovary (CHO) cell-derived Master Cell Bank (MCB) intended for biological production. Scientists from the sponsor (Eli Lilly and Company) and the testing service company (BioReliance) jointly conducted a systematic investigation in an attempt to determine the root cause of the contamination. Our investigation resulted in the identification of the viral nature of the contaminant. Subsequent experiments indicated that the viral contaminant was a non-enveloped and non-hemadsorbing virus. Transmission electron microscopy (TEM) revealed that the viral contaminant was 25-30 nm in size and morphologically resembled viruses of the family Picornaviridae. The contaminant virus was readily inactivated when exposed to acidic pH, suggesting that the viral contaminant was a member of rhinoviruses. Although incapable of infecting CHO cells, the viral contaminant replicated efficiently in Vero cell with a life cycle of approximately 16 h. Our investigation provided compelling data demonstrating that the viral contaminant did not originate from the MCB. Instead, it was introduced into the process during cell passaging and a possible entry point was proposed. We identified the viral contaminant as an equine rhinitis A virus using molecular cloning and DNA sequencing. Finally, our investigation led us to conclude that the source of the viral contaminant was the equine serum added to the cell growth medium in the 9 CFR bovine virus test.

The riddle of sex: biological theories of sexual difference in the early twentieth-century.

Science.gov (United States)

Ha, Nathan Q

2011-01-01

At the turn of the twentieth century, biologists such as Oscar Riddle, Thomas Hunt Morgan, Frank Lillie, and Richard Goldschmidt all puzzled over the question of sexual difference, the distinction between male and female. They all offered competing explanations for the biological cause of this difference, and engaged in a fierce debate over the primacy of their respective theories. Riddle propounded a metabolic theory of sex dating from the late-nineteenth century suggesting that metabolism lay at the heart of sexual difference. Thomas Hunt Morgan insisted on the priority of chromosomes, Frank Lillie emphasized the importance of hormones, while Richard Goldschmidt supported a mixed model involving both chromosomes and hormones. In this paper, I will illustrate how the older metabolic theory of sex was displaced when those who argued for the relatively newer theories of chromosomes and hormones gradually formed an alliance that accommodated each other and excluded the metabolic theory of sex. By doing so, proponents of chromosomes and hormones established their authority over the question of sexual difference as they laid the foundations for the new disciplines of genetics and endocrinology. Their debate raised urgent questions about what constituted sexual difference, and how scientists envisioned the plasticity and controllability of this difference. These theories also had immediate political and cultural consequences at the turn of the twentieth century, especially for the eugenic and feminist movements, both of which were heavily invested in knowledge of sex and its determination, ascertainment, and command.

The Autism Impact Measure (AIM): Initial Development of a New Tool for Treatment Outcome Measurement

Science.gov (United States)

Kanne, Stephen M.; Mazurek, Micah O.; Sikora, Darryn; Bellando, Jayne; Branum-Martin, Lee; Handen, Benjamin; Katz, Terry; Freedman, Brian; Powell, Mary Paige; Warren, Zachary

2014-01-01

The current study describes the development and psychometric properties of a new measure targeting sensitivity to change of core autism spectrum disorder (ASD) symptoms, the Autism Impact Measure (AIM). The AIM uses a 2-week recall period with items rated on two corresponding 5-point scales (frequency and impact). Psychometric properties were…

Sustainability with an Ethical Aim: Lessons from an American Nun in Amazonia

Science.gov (United States)

Demaree, Stephanie

2012-01-01

Research Topic: An exploration into human imagination, ethical aim and action are the progenitors for reconciliation between humans and their environment. This study of two successful projects in Brazil provides an example of working toward a balance between human endeavors and sustainable environments. This inquiry is an exploration that…

Interventions aimed at communities to inform and/or educate about early childhood vaccination.

Science.gov (United States)

Saeterdal, Ingvil; Lewin, Simon; Austvoll-Dahlgren, Astrid; Glenton, Claire; Munabi-Babigumira, Susan

2014-11-19

A range of strategies are used to communicate with parents, caregivers and communities regarding child vaccination in order to inform decisions and improve vaccination uptake. These strategies include interventions in which information is aimed at larger groups in the community, for instance at public meetings, through radio or through leaflets. This is one of two reviews on communication interventions for childhood vaccination. The companion review focuses on face-to-face interventions for informing or educating parents. To assess the effects of interventions aimed at communities to inform and/or educate people about vaccination in children six years and younger. We searched CENTRAL, MEDLINE, EMBASE and five other databases up to July 2012. We searched for grey literature in the Grey Literature Report and OpenGrey. We also contacted authors of included studies and experts in the field. There were no language, date or settings restrictions. Individual or cluster-randomised and quasi-randomised controlled trials, interrupted time series (ITS) and repeated measures studies, and controlled before-and-after (CBA) studies. We included interventions aimed at communities and intended to inform and/or educate about vaccination in children six years and younger, conducted in any setting. We defined interventions aimed at communities as those directed at a geographic area, and/or interventions directed to groups of people who share at least one common social or cultural characteristic. Primary outcomes were: knowledge among participants of vaccines or vaccine-preventable diseases and of vaccine service delivery; child immunisation status; and unintended adverse effects. Secondary outcomes were: participants' attitudes towards vaccination; involvement in decision-making regarding vaccination; confidence in the decision made; and resource use or cost of intervention. Two authors independently reviewed the references to identify studies for inclusion. We extracted data and

Advanced Industrial Materials (AIM) Program: Compilation of project summaries and significant accomplishments, FY 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This report contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Subject areas covered are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

Listen, live and learn: A review of the application process, aiming to ...

African Journals Online (AJOL)

The Listen, Live and Learn (LLL) initiative at Stellenbosch University (SU) is a senior student housing model with the aim of providing an experiential opportunity for students to make contact with 'the other'. It is posited on the social contact theory assumption that if people of different genders, races, ethnicities, and/or ...

The Annual Review of Information Science and Technology: Its Aims and Impact.

Science.gov (United States)

Cuadra, Carlos A.

The major aims of the "Annual Review of Information Science and Technology" are (1) to describe and appraise progress in information science and technology; (2) to provide a systematic, dependable tool that can relieve professionals from winnowing through a wealth of literature in their field each year; (3) to direct the reader to…

Transition probabilities and radiative decay constants of the excited levels of Ne

International Nuclear Information System (INIS)

Wosinski, L.

1981-01-01

Transition probabilities for eight optical transitions between the 3p and 3d neon levels have been measured by the ''plasma transparency method''. The transitions probabilities are placed on an absolute scale by use of the recently reported values for the 4p→3s transitions. The measurements of induced changes in populations allowed the determination of the ratios of the radiative decay constants for the 4p and 3d levels. The experimental results are compared with the theoretically calculated transitions probabilities of Murphy and Lilly. (author)

The current status of immunotoxins: an overview of experimental and clinical studies as presented at the Third International Symposium on Immunotoxins.

Science.gov (United States)

Uckun, F M; Frankel, A

1993-02-01

The Third International Symposium on Immunotoxins was held on June 19-21, 1992 in Orlando, Florida. This symposium was sponsored by NATO, NIH, Pierce Chemical Company, Walt Disney Cancer Institute at Florida Hospital, Duke Comprehensive Cancer Center, Xoma, Immunogen, Seragen, Bristol-Myers Squibb, Chiron, Ortho Biotech, Upjohn, Merck Sharp & Dohme Research Laboratories, Abbot Laboratories, Lilly Research Laboratories, and Evans & Sutherland. The Pierce Immunotoxin Award which recognizes outstanding contributions to immunotoxin research and development, was presented to Drs David FitzGerald, Fatih Uckun, David Eisenberg, and Ira Wool, for their contributions to the immunotoxin field.

Nava tiigi ääres seiklevad Hunt ja Rebane / Liisi Seil ; kommenteerinud Pille Põllumäe

Index Scriptorium Estoniae

Seil, Liisi, 1971-

2009-01-01

17.-19. juulini Lilli külas Nava talus toimuvast 4. Nava lava festivalist. 19. 07 mängib Karksi valla kultuurikeskuse noorteteater "O" lasteetendust "Hundi ja Rebase lend lõunanabale", mille on Nava talu peremehe Jaak Kõdari raamatu "Kriimureinulised lood. 3, Argonaudid" põhjal kirjutanud ja lavastanud Silvia Soro. Kostüümid tegi Thea Ilusmets. 17., 18. ja 19. 07 mängitakse Jaak Kõdari mulgikeelset külanäitemängu "Kõik läheb mööda, kõik tuleb jälle. 1912-1918", lavastaja Silvia Soro

Criação, afetação e paradoxo em psicanálise Creation, affection and paradox in psychoanalysis

Directory of Open Access Journals (Sweden)

Eduardo Rozenthal

2009-06-01

Full Text Available Pretende-se alinhavar uma compreensão teórica da análise de um sujeito compulsivo da atualidade. As subjetividades contemporâneas sofrem de adversidades da criação de si, para além da dinâmica das representações, entre o recalcado e o sintoma. A compulsão é uma tentativa malograda de inscrição pulsional e somente o paradoxo da afetação transferencial - ao mesmo tempo, afetar e ser afetado - contribuiria para o desvio do gozo. Para além da interpretação do que o analisante não diz, trata-se da possibilidade de acolhimento do que jamais poderia ser dito, mas apenas sentido.The aim of the article is to outline a theoretical understanding of a current compulsive subject analysis. The contemporary subjectivities suffer of self-creation problems, beyond the dynamic of the representations, between the repressed and the symptom. The compulsion is a failure pulsional inscription try and only the transferencial affection paradox - at the same time, to affect and to be affected - would contribute to lust (jouissance deviation. Beyond the interpretation of what the analysand doesn't say, what is at stake is the possibility of the reception that could never be said, but only felt.

Free to choose. The Buddhist view.

Science.gov (United States)

Gnanawimala, B

1993-10-27

This Buddhist view of family planning is presented by a lecturer at the Buddhist and Pali University in Colombo. Birth control was not mentioned in the earliest Buddhist teachings because there was no urgency for population control. Large families were honored, and the expectation was that as many children as possible should be produced. Buddha did not mention the merits of population increase. Buddha considered family size a personal family choice. Buddhist's disciples are expected to be celibate. Chastity is encouraged among men and women. The Dhammapada, a canonical work of Buddha, mentions not increasing population and teaches ways of keeping the mind free from lust. Reduction of births is recommended. Buddha placed importance on the right of human beings to exist and procreate peacefully. The right to life begins in the womb, and abortion is a violation of the rights of the unborn child. The formation of life is absolutely dependent upon a mother's physical fitness, sexual intercourse, and the arrival of "a being's dislocated transmigratory unit of fivefold energy (gandhabba)." Couples are free to choose a fetus from any energy body. Sterilization and the use of contraceptives, therefore, do not destroy life. Buddha commended abstinence, which is similar to chastity. The principle teachings of Buddha aim to end suffering. If procreation strains the ability of resources to support life, then procreation is against the basic principles of Buddha.

Iran's Nuclear Program and Its Official Aim of Producing Nuclear Energy

International Nuclear Information System (INIS)

Khazaneh, Reza

2008-01-01

Iran says it aims at developing nuclear energy and mastering the whole cycle of nuclear combustion. After the withdrawal of Western experts, Russia took over the building of nuclear plants, without clearly explaining what it really intended to do. Nowadays Iran has no international assistance, either to complete the nuclear plants, or to achieve full control of the nuclear combustion cycle. Going forward seems difficult, even though Iran has proved capable of mobilizing a good deal of energy to attain its target

R. S. Peters and J. H. Newman on the Aims of Education

Science.gov (United States)

Ozolins, Janis T.

2013-01-01

R. S. Peters never explicitly talks about wisdom as being an aim of education. He does, however, in numerous places, emphasize that education is of the whole person and that, whatever else it might be about, it involves the development of knowledge and understanding. Being educated, he claims, is incompatible with being narrowly specialized.…

Progress of MCT Detector Technology at AIM Towards Smaller Pitch and Lower Dark Current

Science.gov (United States)

Eich, D.; Schirmacher, W.; Hanna, S.; Mahlein, K. M.; Fries, P.; Figgemeier, H.

2017-09-01

We present our latest results on cooled p-on- n planar mercury cadmium telluride (MCT) photodiode technology. Along with a reduction in dark current for raising the operating temperature ( T op), AIM INFRAROT-MODULE GmbH (AIM) has devoted its development efforts to shrinking the pixel size. Both are essential requirements to meet the market demands for reduced size, weight and power and high-operating temperature applications. Detectors based on the p-on- n technology developed at AIM now span the spectrum from the mid-wavelength infrared (MWIR) to the very long wavelength infrared (VLWIR) with cut-off wavelengths from 5 μm to about 13.5 μm at 80 K. The development of the p-on- n technology for VLWIR as well as for MWIR is mainly implemented in a planar photodetector design with a 20- μm pixel pitch. For the VLWIR, dark currents significantly reduced as compared to `Tennant's Rule 07' are demonstrated for operating temperatures between 30 K and 100 K. This allows for the same dark current performance at a 20 K higher operating temperature than with previous AIM technology. For MWIR detectors with a 20- μm pitch, noise equivalent temperature differences of less than 30 mK are obtained up to 170 K. This technology has been transferred to our small pixel pitch high resolution (XGA) MWIR detector with 1024 × 768 pixels at a 10- μm pitch. Excellent performance at an operating temperature of 160 K is demonstrated.

DMPD: Fifty years of interferon research: aiming at a moving target. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available mmunity. 2006 Sep;25(3):343-8. (.png) (.svg) (.html) (.csml) Show Fifty years of interferon research: aiming at a moving target. Pubm...edID 16979566 Title Fifty years of interferon research: aiming at a moving target.

The medicalization of love.

Science.gov (United States)

Earp, Brian D; Sandberg, Anders; Savulescu, Julian

2015-07-01

Pharmaceuticals or other emerging technologies could be used to enhance (or diminish) feelings of lust, attraction, and attachment in adult romantic partnerships. Although such interventions could conceivably be used to promote individual (and couple) well-being, their widespread development and/or adoption might lead to the 'medicalization' of human love and heartache--for some, a source of a serious concern. In this essay, we argue that the medicalization of love need not necessarily be problematic, on balance, but could plausibly be expected to have either good or bad consequences depending upon how it unfolds. By anticipating some of the specific ways in which these technologies could yield unwanted outcomes, bioethicists and others can help to direct the course of love's medicalization--should it happen to occur--more toward the 'good' side than the 'bad.'

KONTRIBUSI ILMU TASAWUF DALAM PEMBANGUNAN KARAKTER BANGSA

Directory of Open Access Journals (Sweden)

Asmaran As

2014-04-01

Full Text Available Sufism is a pure consciousness that is able to direct the human’s soul to be good one and has a noble attitude and one of the most things in determining of a person’s behavior is the one’s own desires. Lust basically should not be turned off, but it must be controlled and directed to conduct an appreciable act. In order to make the soul has such a feeling, it takes hard efforts to turn the nature on that Allah swt has given since he was still in the spiritual realm. In character development, the people in Sufism said that there are stages that must be passed are tathahhur, tahaqquq and takhalluq, or in other terms with similar meaning, namely takhalli, tahalli, and tajalli.

An intervention aimed at reducing plagiarism in undergraduate nursing students.

Science.gov (United States)

Smedley, Alison; Crawford, Tonia; Cloete, Linda

2015-05-01

Plagiarism is a current and developing problem in the tertiary education sector where students access information and reproduce it as their own. It is identified as occurring in many tertiary level degrees including nursing and allied health profession degrees. Nursing specifically, is a profession where standards and ethics are required and honesty is paramount. The aim of this study was to evaluate the change in nursing student's knowledge and understanding of plagiarism before and after an educational intervention in their first semester of the Bachelor of nursing degree at a private college of higher education in Sydney, Australia. This study concluded that an educational intervention can increase knowledge and awareness of plagiarism among nursing students. Copyright © 2014 Elsevier Ltd. All rights reserved.

The AI&M procedure for learning from incomplete data

DEFF Research Database (Denmark)

Jaeger, Manfred

2006-01-01

We investigate methods for parameter learning from incomplete data that is not missing at random. Likelihood-based methods then require the optimization of a profile likelihood that takes all possible missingness mechanisms into account. Optimizing this profile likelihood poses two main difficult......We investigate methods for parameter learning from incomplete data that is not missing at random. Likelihood-based methods then require the optimization of a profile likelihood that takes all possible missingness mechanisms into account. Optimizing this profile likelihood poses two main...... by operations in the space of data completions, rather than directly in the parameter space of the profile likelihood. We apply the AI\\&M method to learning parameters for Bayesian networks. The method is compared against conservative inference, which takes into account each possible data completion......, and against EM. The results indicate that likelihood-based inference is still feasible in the case of unknown missingness mechanisms, and that conservative inference is unnecessarily weak. On the other hand, our results also provide evidence that the EM algorithm is still quite effective when the data...

Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides

DEFF Research Database (Denmark)

Gunnell, David; Knipe, Duleeka; Chang, Shu Sen

2017-01-01

Background: Pesticide self-poisoning accounts for 14–20% of suicides worldwide. Regulation aimed at restricting access to pesticides or banning highly hazardous pesticides is one approach to reducing these deaths. We systematically reviewed the evidence of the effectiveness of pesticide regulation...... in reducing the incidence of pesticide suicides and overall suicides. Methods: We did a systematic review of the international evidence. We searched MEDLINE, PsycINFO, and Embase for studies published between Jan 1, 1960, and Dec 31, 2016, which investigated the effect of national or regional bans, and sales...... or import restrictions, on the availability of one or more pesticides and the incidence of suicide in different countries. We excluded other interventions aimed at limiting community access to pesticides. We extracted data from studies presenting pesticide suicide data and overall suicide data from before...

Alginate Immobilization of Metabolic Enzymes (AIME) for High ...

Science.gov (United States)

Alginate Immobilization of Metabolic Enzymes (AIME) for High-Throughput Screening Assays DE DeGroot, RS Thomas, and SO SimmonsNational Center for Computational Toxicology, US EPA, Research Triangle Park, NC USAThe EPA’s ToxCast program utilizes a wide variety of high-throughput screening (HTS) assays to assess chemical perturbations of molecular and cellular endpoints. A key criticism of using HTS assays for toxicity assessment is the lack of xenobiotic metabolism (XM) which precludes both metabolic detoxification as well as bioactivation of chemicals tested in vitro thereby mischaracterizing the potential risk posed by these chemicals. To address this deficiency, we have developed an extracellular platform to retrofit existing HTS assays with XM activity. This platform utilizes the S9 fraction of liver homogenate encapsulated in an alginate gel network which reduces the cytotoxicity caused by direct addition of S9 to cells in culture. Alginate microspheres containing encapsulated human liver S9 were cross-linked to solid supports extending from a 96-well plate lid and were assayed using a pro-luciferin substrate specific for CYP3A4 (IPA). We demonstrate that S9 was successfully encapsulated and remained enzymatically active post-encapsulation with 5-10X the CYP3A4 activity as compared to 1 µg solubilized human liver S9. Ketoconazole, a known inhibitor of human CYP3A4, inhibited CYP3A4 activity in a concentration-dependent manner (IC50: 0.27 µM) and inhibiti

Law proposition aiming to organize the sustainable management of radioactive wastes

International Nuclear Information System (INIS)

Bataille, Ch.; Ayrault, J.M.; Hollande, F.; Dose, F.; Dumont, J.L.; Brottes, F.; Le Deaut, J.Y.

2006-02-01

In 1991 the France decided to intensify its researches in the high activity radioactive wastes management domain. The law of the 30 December 1991 relative to the radioactive wastes management, decided that a period of 15 years would be devoted to the research of very long dated solutions. This law proposition takes into account these researches results and aims to define a policy of radioactive wastes management in the framework of a sustainable development. The authors present and discuss the different articles of the law proposition. (A.L.B.)

On Heterogeneity in Mobile Sensing Applications Aiming at Representative Data Collection

DEFF Research Database (Denmark)

Blunck, Henrik; Bouvin, Niels Olof; Franke, Tobias

2013-01-01

Gathering representative data using mobile sensing to answer research questions is becoming increasingly popular, driven by growing ubiquity and sensing capabilities of mobile devices. However, there are pitfalls along this path, which introduce heterogeneity in the gathered data, and which...... on collective, mobile sensed data are valid. In this paper, we aim to inform researchers and developers about mobile sensing data heterogeneity and ways to combat it. We do so via distilling a vocabulary of underlying causes, and via describing their effects on mobile sensing---building on experiences from...

America: AGA [American Gas Association] initiative aims to boost gas demand

International Nuclear Information System (INIS)

Fraser, K.M.

1992-01-01

This article focuses on the aim of the American Gas Association to increase natural gas demand in the key areas of gas electric generation, natural gas vehicles, gas cooling, and conversion of oil burning facilities, electric water heaters and household appliances such as space heating, stoves, washers and lighting. The need to improve the reliability of natural gas supplies is discussed. It is anticipated that natural gas will not replace coal as the main energy source for power generation, but that it will help utilities to meet environmental regulations. (UK)

Using the RE-AIM framework to evaluate physical activity public health programs in México.

Science.gov (United States)

Jauregui, Edtna; Pacheco, Ann M; Soltero, Erica G; O'Connor, Teresia M; Castro, Cynthia M; Estabrooks, Paul A; McNeill, Lorna H; Lee, Rebecca E

2015-02-19

Physical activity (PA) public health programming has been widely used in Mexico; however, few studies have documented individual and organizational factors that might be used to evaluate their public health impact. The RE-AIM framework is an evaluation tool that examines individual and organizational factors of public health programs. The purpose of this study was to use the RE-AIM framework to determine the degree to which PA programs in Mexico reported individual and organizational factors and to investigate whether reporting differed by the program's funding source. Public health programs promoting PA were systematically identified during 2008-2013 and had to have an active program website. Initial searches produced 23 possible programs with 12 meeting inclusion criteria. A coding sheet was developed to capture behavioral, outcome and RE-AIM indicators from program websites. In addition to targeting PA, five (42%) programs also targeted dietary habits and the most commonly reported outcome was change in body composition (58%). Programs reported an average of 11.1 (±3.9) RE-AIM indicator items (out of 27 total). On average, 45% reported reach indicators, 34% reported efficacy/effectiveness indicators, 60% reported adoption indicators, 40% reported implementation indicators, and 35% reported maintenance indicators. The proportion of RE-AIM indicators reported did not differ significantly for programs that were government supported (M = 10, SD = 3.1) and programs that were partially or wholly privately or corporately supported (M = 12.0, SD = 4.4). While reach and adoption of these programs were most commonly reported, there is a need for stronger evaluation of behavioral and health outcomes before the public health impact of these programs can be established.

78 FR 50135 - AIMS Worldwide, Inc., Apollo Capital Group, Inc., CommunitySouth Financial Corp., Last Mile...

Science.gov (United States)

2013-08-16

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] AIMS Worldwide, Inc., Apollo Capital Group, Inc., CommunitySouth Financial Corp., Last Mile Logistics Group, Inc., Made in America Entertainment... securities of AIMS Worldwide, Inc. because it has not filed any periodic reports since the period ended June...

The Research Site Vrchslatina – an experimental design and the main aims

Directory of Open Access Journals (Sweden)

Konôpka Bohdan

2013-09-01

Full Text Available The research site “Vrchslatina” was established in the spring of 2009 with the aim of studying production processes and the structure of net primary productivity in young forest stands. The beech and spruce stands grown at the site were selected because they originated from natural regeneration and are nearly of the same age. In 2009, we established 5 research plots in each stand with the aim of measuring basic tree characteristics. Moreover, we excavated entire trees to construct allometric relations for the specific tree compartments. In the consecutive years (2010, 2011 and 2012, we also included grass communities dominated by Calamagrostis epigejos in our studies. Besides studying production processes of all tree compartments (i.e. for trees: foliages, branches, stem, coarse and fine roots, for grasses and herbs: below- and above-ground parts, we monitored several atmospheric characteristics, followed by soil characteristics and eventually added a measurement of soil respiration. The results indicated that forest stands (even though they were in their initial growth stages sequestrated much more carbon than the grass communities. Moreover, we proved the considerable influence of climatic conditions (especially the sum of precipitation in the particular years for net primary productivity.

RE-AIM in Clinical, Community, and Corporate Settings: Perspectives, Strategies, and Recommendations to Enhance Public Health Impact

Directory of Open Access Journals (Sweden)

Samantha M. Harden

2018-03-01

Full Text Available The RE-AIM Framework is a planning and evaluation model that has been used in a variety of settings to address various programmatic, environmental, and policy innovations for improving population health. In addition to the broad application and diverse use of the framework, there are lessons learned and recommendations for the future use of the framework across clinical, community, and corporate settings. The purposes of this article are to: (A provide a brief overview of the RE-AIM Framework and its pragmatic use for planning and evaluation; (B offer recommendations to facilitate the application of RE-AIM in clinical, community, and corporate settings; and (C share perspectives and lessons learned about employing RE-AIM dimensions in the planning, implementation, and evaluation phases within these different settings. In this article, we demonstrate how the RE-AIM concepts and elements within each dimension can be applied by researchers and practitioners in diverse settings, among diverse populations and for diverse health topics.

Microwave dielectric absorption spectroscopy aiming at novel dosimetry using DNAs

Energy Technology Data Exchange (ETDEWEB)

Izumi, Yoshinobu; Hirayama, Makoto; Matuo, Youichirou [Research Institute of Nuclear Engineering, University of Fukui, Fukui (Japan); Sunagawa, Takeyoshi [Fukui University of Technology, Fukui (Japan)

2017-03-15

We are developing L-band and S-band microwave dielectric absorption systems aiming novel dosimetry using DNAs, such as plasmid DNA and genomic DNA, and microwave technology. Each system is composed of a cavity resonator, analog signal generator, circulator, power meter, and oscilloscope. Since the cavity resonator is sensitive to temperature change, we have made great efforts to prevent the fluctuation of temperature. We have developed software for controlling and measurement. By using this system, we can measure the resonance frequency, f, and ΔQ (Q is a dimensionless parameter that describes how under-damped an oscillator or resonator is, and characterizes a resonator’s bandwidth relative to its center frequency) within about 3 minutes with high accuracy. This system will be expected to be applicable to DNAs evaluations and to novel dosimetric system.

Developing a dashboard to help measure and achieve the triple aim: a population-based cohort study.

Science.gov (United States)

Seow, Hsien-Yeang; Sibley, Lyn M

2014-08-30

Health system planners aim to pursue the three goals of Triple Aim: 1) reduce health care costs; 2) improve population health; and 3) improve the care experience. Moreover, they also need measures that can reliably predict future health care needs in order to manage effectively the health system performance. Yet few measures exist to assess Triple Aim and predict future needs at a health system level. The purpose of this study is to explore the novel application of a case-mix adjustment method in order to measure and help improve the Triple Aim of health system performance. We applied a case-mix adjustment method to a population-based analysis to assess its usefulness as a measure of health system performance and Triple Aim. The study design was a retrospective, cohort study of adults from Ontario, Canada using administrative databases: individuals were assigned a predicted illness burden score using a case-mix adjustment system from diagnoses and health utilization data in 2008, and then followed forward to assess the actual health care utilization and costs in the following year (2009). We applied the Johns Hopkins Adjusted Clinical Group (ACG) Case-Mix System to categorize individuals into 60 levels of healthcare need, called ACGs. The outcomes were: 1) Number of individuals per ACG; 2) Total system costs per ACG; and 3) Mean cost per person per ACG, which together formed a health system "dashboard". We identified 11.4 million adults. 16.1% were aged 65 or older, 3.2 million (28%) did not use health care services that year, and 45,000 (0.4%) were in the highest acuity ACG category using 12 times more than an average adult. The sickest 1%, 5% and 15% of the population use about 10%, 30% and 50% of total health system costs respectively. The dashboard measures 2 dimensions of Triple Aim: 1) reduced costs: when total system costs per ACG or when average costs per person is reduced; and 2) improved population health: when more people move into healthier rather than

AIM satellite-based research bridges the unique scientific aspects of the mission to informal education programs globally

Science.gov (United States)

Robinson, D.; Maggi, B.

2003-04-01

The Education and Public Outreach (EPO) component of the satellite-based research mission "Aeronomy of Ice In the Mesosphere" (AIM) will bridge the unique scientific aspects of the mission to informal education organizations. The informal education materials developed by the EPO will utilize AIM data and educate the public about the environmental implications associated with the data. This will assist with creating a scientifically literate workforce and in developing a citizenry capable of making educated decisions related to environmental policies and laws. The objective of the AIM mission is to understand the mechanisms that cause Polar Mesospheric Clouds (PMCs) to form, how their presence affects the atmosphere, and how change in the atmosphere affects them. PMCs are sometimes known as Noctilucent Clouds (NLCs) because of their visibility during the night from appropriate locations. The phenomenon of PMCs is an observable indicator of global change, a concern to all citizens. Recent sightings of these clouds over populated regions have compelled AIM educators to expand informal education opportunities to communities worldwide. Collaborations with informal organizations include: Museums/Science Centers; NASA Sun-Earth Connection Forum; Alaska Native Ways of Knowing Project; Amateur Noctilucent Cloud Observers Organization; National Parks Education Programs; After School Science Clubs; Public Broadcasting Associations; and National Public Radio. The Native Ways of Knowing Project is an excellent example of informal collaboration with the AIM EPO. This Alaska based project will assist native peoples of the state with photographing NLCs for the EPO website. It will also aid the EPO with developing materials for informal organizations that incorporate traditional native knowledge and science, related to the sky. Another AIM collaboration that will offer citizens lasting informal education opportunities is the one established with the United States National Parks

Actuator and sensor selection for an active vehicle suspension aimed at robust performance

NARCIS (Netherlands)

Wal, van de M.M.J.; Philips, P.P.H.H.; Jager, de A.G.

1998-01-01

A recently presented method for actuator and sensor selection for linear control systems is applied and evaluated for an active vehicle suspension control problem. The aim is to eliminate the actuator/sensor combinations for which no controller exists that achieves a specified level of robust

The Scavenger Protein Apoptosis Inhibitor of Macrophages (AIM) Potentiates the Antimicrobial Response against Mycobacterium tuberculosis by Enhancing Autophagy

Science.gov (United States)

Sanjurjo, Lucía; Amézaga, Núria; Vilaplana, Cristina; Cáceres, Neus; Marzo, Elena; Valeri, Marta; Cardona, Pere-Joan; Sarrias, Maria-Rosa

2013-01-01

Apoptosis inhibitor of macrophages (AIM), a scavenger protein secreted by tissue macrophages, is transcriptionally regulated by the nuclear receptor Liver X Receptor (LXR) and Retinoid X Receptor (RXR) heterodimer. Given that LXR exerts a protective immune response against M. tuberculosis, here we analyzed whether AIM is involved in this response. In an experimental murine model of tuberculosis, AIM serum levels peaked dramatically early after infection with M. tuberculosis, providing an in vivo biological link to the disease. We therefore studied the participation of AIM in macrophage response to M. tuberculosis in vitro. For this purpose, we used the H37Rv strain to infect THP-1 macrophages transfected to stably express AIM, thereby increasing infected macrophage survival. Furthermore, the expression of this protein enlarged foam cell formation by enhancing intracellular lipid content. Phagocytosis assays with FITC-labeled M. tuberculosis bacilli indicated that this protein was not involved in bacterial uptake; however, AIM expression decreased the number of intracellular cfus by up to 70% in bacterial killing assays, suggesting that AIM enhances macrophage mycobactericidal activity. Accordingly, M. tuberculosis-infected AIM-expressing cells upregulated the production of reactive oxygen species. Moreover, real-time PCR analysis showed increased mRNA levels of the antimicrobial peptides cathelicidin and defensin 4B. These increases were concomitant with greater cellular concentrations of the autophagy-related molecules Beclin 1 and LC3II, as well as enhanced acidification of mycobacterial phagosomes and LC3 co-localization. In summary, our data support the notion that AIM contributes to key macrophage responses to M. tuberculosis. PMID:24223991

Basic concept and its aims of E-journal of advanced maintenance

International Nuclear Information System (INIS)

Miya, Kenzo

2009-01-01

This article describes basic concept and aims of EJAM with history of effort to realize the launching of it. It took about three years until launching of the journal through approach to EPRI and negotiation with international publishing companies. It consists of three major articles. They are 1) general articles, 2) academic papers and 3) maintenance technique to be applied to repairing of components of nuclear power plants. All together of these articles may contribute to understanding of clear image of what maintenance is in this journal. Finally future image of this journal is described in light of maintenance evolution. (author)

AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA

Directory of Open Access Journals (Sweden)

Yuki Nakaya

2017-07-01

Full Text Available Cytosolic DNAs derived from retrotransposons serve as pathogen-associated molecular patterns for pattern recognition receptors (PRRs that stimulate the induction of interferons (IFNs and other cytokines, leading to autoimmune disease. Cyclic GMP-AMP synthase is one PRR that senses retrotransposon DNA, activating type I IFN responses through the stimulator of IFN genes (STING. Absent in melanoma 2 (AIM2-like receptors (ALRs have also been implicated in these pathways. Here we show that the mouse ALR IFI205 senses cytosolic retrotransposon DNA independently of cyclic GMP-AMP production. AIM2 antagonizes IFI205-mediated IFN induction activity by sequestering it from STING. We also found that the complement of genes located in the ALR locus in C57BL/6 and AIM2 knockout mice are different and unique, which has implications for interpretation of the sensing of pathogens in different mouse strains. Our data suggest that members of the ALR family are critical to the host IFN response to endogenous DNA.

High quality data: An evaluation of AIM data quality and data quality procedures

Science.gov (United States)

The goal of every monitoring program is to collect high-quality data which can then be used to provide information to decision makers. The Bureau of Land Management (BLM) Assessment, Inventory, and Monitoring (AIM) program is one such data set which provides rangeland status, condition, and trend in...

Viticulture microzoning: a functional approach aiming to grape and wine qualities

Science.gov (United States)

Bonfante, A.; Agrillo, A.; Albrizio, R.; Basile, A.; Buonomo, R.; De Mascellis, R.; Gambuti, A.; Giorio, P.; Guida, G.; Langella, G.; Manna, P.; Minieri, L.; Moio, L.; Siani, T.; Terribile, F.

2014-12-01

This paper aims to test a new physically oriented approach to viticulture zoning at the farm scale, strongly rooted on hydropedology and aiming to achieve a better use of environmental features with respect to plant requirement and wine production. The physics of our approach is defined by the use of soil-plant-atmosphere simulation models which applies physically-based equations to describe the soil hydrological processes and solves soil-plant water status. This study (ZOVISA project) was conducted in a farm devoted to high quality wines production (Aglianico DOC), located in South Italy (Campania region, Mirabella Eclano-AV). The soil spatial distribution was obtained after standard soil survey informed by geophysical survey. Two Homogenous Zones (HZs) were identified; in each one of those a physically based model was applied to solve the soil water balance and estimate the soil functional behaviour (crop water stress index, CWSI) defining the functional Homogeneous Zones (fHzs). In these last, experimental plots were established and monitored for investigating soil-plant water status, crop development (biometric and physiological parameters) and daily climate variables (temperature, solar radiation, rainfall, wind). The effects of crop water status on crop response over must and wine quality were then evaluated in the fHZs. This was performed by comparing crop water stress with (i) crop physiological measurement (leaf gas exchange, chlorophyll a fluorescence, leaf water potential, chlorophyll content, LAI measurement), (ii) grape bunches measurements (berry weight, sugar content, titratable acidity, etc.) and (iii) wine quality (aromatic response). Eventually this experiment has proved the usefulness of the physical based approach also in the case of mapping viticulture microzoning.

Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor

Directory of Open Access Journals (Sweden)

Manetta J

2014-08-01

Full Text Available Joseph Manetta, Holly Bina, Paul Ryan, Niles Fox, Derrick R Witcher, Kristine Kikly Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA Abstract: B-cell activating factor (BAFF is a B-cell survival factor with a key role in B-cell homeostasis and tolerance. Dysregulated BAFF expression may contribute to autoimmune diseases or B-cell malignancies via effects on abnormal B-lymphocyte activation, proliferation, survival, and immunoglobulin secretion. Monoclonal antibodies were generated against human BAFF, characterized for species specificity and affinity, and screened for the ability to neutralize both membrane-bound and soluble BAFF. In addition, studies were undertaken to determine the relative potency of membrane-bound and soluble BAFF. Tabalumab has a high affinity for human, cynomolgus monkey, and rabbit BAFF. No binding to mouse BAFF was detected. Tabalumab was able to neutralize soluble human, cynomolgus monkey, or rabbit BAFF with equal potency. Our data demonstrate that membrane-bound BAFF can be a more potent stimulus for B-cells than soluble BAFF, and tabalumab also neutralized membrane-bound BAFF. Tabalumab prevented BAFF from binding to BAFF receptors and demonstrated pharmacodynamic effects in human BAFF transgenic mice. Tabalumab is a high-affinity human antibody with neutralizing activity against membrane-bound and soluble BAFF. Given our findings that membrane-bound BAFF can have greater in vitro potency than soluble BAFF, neutralization of both forms of BAFF is likely to be important for optimal therapeutic effect. Keywords: autoimmunity, B-cell malignancies, B-cell survival factor, BAFF

Interpretive Research Aiming at Theory Building: Adopting and Adapting the Case Study Design

Science.gov (United States)

Diaz Andrade, Antonio

2009-01-01

Although the advantages of case study design are widely recognised, its original positivist underlying assumptions may mislead interpretive researchers aiming at theory building. The paper discusses the limitations of the case study design for theory building and explains how grounded theory systemic process adds to the case study design. The…

Aims and Scope

Institute of Scientific and Technical Information of China (English)

2009-01-01

<正>The focus of the China Journal of Accounting Research is to publish theoretical and empirical research papers that use contemporary research methodologies to investigate issues about accounting,finance,auditing and corporate governance in China,the Greater China region and other emerging markets.The Journal also publishes insightful commentaries about China-related accounting research.The Journal encourages the application of economic and sociological theories to analyze and

Aims and Scope

Institute of Scientific and Technical Information of China (English)

2013-01-01

<正>The focus of the China Journal of Accounting Research is to publish theoretical and empirical research papers that use contemporary research methodologies to investigate issues about accounting,finance,auditing and corporate governance in China,the Greater China region and other emerging markets.The Journal also publishes insightful commentaries about China-related accounting research.The Journal encourages the application of economic and sociological theories to analyze and explain accounting issues under Chinese capital markets accurately and succinctly.The published research articles of the Journal will enable scholars

Aims and Scope

Institute of Scientific and Technical Information of China (English)

2010-01-01

<正>The focus of the China Journal of Accounting Research is to publish theoretical and empirical research papers that use contemporary research methodologies to investigate issues about accounting,finance,auditing and corporate governance in China,the Greater China region and other emerging markets.The Journal also publishes insightful commentaries about China-related accounting research.The Journal encourages the application of economic and sociological theories to analyze and explain accounting issues within the legal and institutional framework of China,and

Tracking, aiming, and hitting the UAV with ordinary assault rifle

Science.gov (United States)

Racek, František; Baláž, Teodor; Krejčí, Jaroslav; Procházka, Stanislav; Macko, Martin

2017-10-01

The usage small-unmanned aerial vehicles (UAVs) is significantly increasing nowadays. They are being used as a carrier of military spy and reconnaissance devices (taking photos, live video streaming and so on), or as a carrier of potentially dangerous cargo (intended for destruction and killing). Both ways of utilizing the UAV cause the necessity to disable it. From the military point of view, to disable the UAV means to bring it down by a weapon of an ordinary soldier that is the assault rifle. This task can be challenging for the soldier because he needs visually detect and identify the target, track the target visually and aim on the target. The final success of the soldier's mission depends not only on the said visual tasks, but also on the properties of the weapon and ammunition. The paper deals with possible methods of prediction of probability of hitting the UAV targets.

Ancestry informative markers: inference of ancestry in aged bone samples using an autosomal AIM-Indel multiplex.

Science.gov (United States)

Romanini, Carola; Romero, Magdalena; Salado Puerto, Mercedes; Catelli, Laura; Phillips, Christopher; Pereira, Rui; Gusmão, Leonor; Vullo, Carlos

2015-05-01

Ancestry informative markers (AIMs) can be useful to infer ancestry proportions of the donors of forensic evidence. The probability of success typing degraded samples, such as human skeletal remains, is strongly influenced by the DNA fragment lengths that can be amplified and the presence of PCR inhibitors. Several AIM panels are available amongst the many forensic marker sets developed for genotyping degraded DNA. Using a 46 AIM Insertion Deletion (Indel) multiplex, we analyzed human skeletal remains of post mortem time ranging from 35 to 60 years from four different continents (Sub-Saharan Africa, South and Central America, East Asia and Europe) to ascertain the genetic ancestry components. Samples belonging to non-admixed individuals could be assigned to their corresponding continental group. For the remaining samples with admixed ancestry, it was possible to estimate the proportion of co-ancestry components from the four reference population groups. The 46 AIM Indel set was informative enough to efficiently estimate the proportion of ancestry even in samples yielding partial profiles, a frequent occurrence when analyzing inhibited and/or degraded DNA extracts. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Project Management in Behavioural Perspective – Cognitive Biases in the Formulation of the Aim of the Project

Directory of Open Access Journals (Sweden)

Kiełczewski Dariusz

2016-09-01

Full Text Available The article contains a behavioural analysis of the aim-formulating stage of the project. The purpose of the article is to point out that in the process of formulating the aim of the project, it comes to such decision-making situations which favour heuristic thinking. The article presents the results of the secondary research. As a result of verified theory, according to which in the process of formulating the aim of the project, the interference in decision-making processes may occur on the part of the heuristics and the resulting cognitive biases.

VALUE JUDGMENTS ON MEANING AND AIMS OF USING GAMES GIVEN BY PRESCHOOL TEACHERS

Directory of Open Access Journals (Sweden)

Inessa V. Usoltseva

2015-01-01

Full Text Available The aim of the presented article is to understand value, aims and practical aspects (frequency, diversity, etc. of using games by preschool teachers with different levels of education.Methods. In the conducted survey, 308 preschool teachers answered a questionnaire developed by leading researcher in ethnopedagogy of play V. M. Grigoriev. Examinees were divided into three groups different in educational level (undergraduated, graduated from college, specialized secondary education. The data were analyzed by comparing value judgments about meaning and aims of using games given by preschool teachers with different levels of education. Also value judgments were compared with practical aspects (frequency, diversity, etc. of the use of games in teachers’ professional work, and with their degree of satisfaction with it. Special attention was paid to the usage of ethno games. The analysis was done out in the program stаstistica 5.0 v and using the methods of nonparametric statistics.Results. The results have showed statistically significant differences between value judgments given by preschool teachers with different levels of education on values of games for developing various children personal qualities, frequency and diversity of use of different types of games. Problems in practical application of national games (Russian national games, games of the people of Russia and people of other countries, international games are designated.Scientific novelty. The author is the first to state the data about divergence influence in valuable representations and purposes of teachers of preschool centres on potential use of game technologies in daily work, and that is reflected in education productivity of younger children; wherein the game is the main activity. Specificity of national games in teaching is shown.Practical significance. The paper materials can be useful at the organisation of methodical work in preschool educational institutions, and by

Large-eddy simulation of swirling pulverized-coal combustion

Energy Technology Data Exchange (ETDEWEB)

Hu, L.Y.; Luo, Y.H. [Shanghai Jiaotong Univ. (China). School of Mechanical Engineering; Zhou, L.X.; Xu, C.S. [Tsinghua Univ., Beijing (China). Dept. of Engineering Mechanics

2013-07-01

A Eulerian-Lagrangian large-eddy simulation (LES) with a Smagorinsky-Lilly sub-grid scale stress model, presumed-PDF fast chemistry and EBU gas combustion models, particle devolatilization and particle combustion models are used to study the turbulence and flame structures of swirling pulverized-coal combustion. The LES statistical results are validated by the measurement results. The instantaneous LES results show that the coherent structures for pulverized coal combustion is stronger than that for swirling gas combustion. The particles are concentrated in the periphery of the coherent structures. The flame is located at the high vorticity and high particle concentration zone.

Strategic Performance Measurement of Research and Development

DEFF Research Database (Denmark)

Parisi, Cristiana; Rossi, Paola

2015-01-01

The paper used an in depth case study to investigate how firms can integrate the strategic performance measurement of R&D with the Balanced Scorecard. Moreover, the paper investigated the crucial role of controller in the decision making process of this integration.The literature review of R......-financial ratio as the R&D measures to introduce in the Balanced Scorecard.In choosing our case study, we have selected the pharmaceutical industry because of its relevant R&D investment. Within the sector we chose the Italian affiliate of a traditional industry leader, Eli Lilly Italia,that was characterized...

The aims of initiation ceremonies at universities: Comparisons in time and space1

Directory of Open Access Journals (Sweden)

N. S. Jansen van Rensburg

1990-03-01

Full Text Available In this article initiation practices at South African universities are analysed and compared with initiation ceremonies described in anthropological literature. It is argued that any initiation ceremony has at least the partial aim of preparing initiates for the roles and functions in society or specific organizations. Naturally a reasonable degree of harmony between the intent of initiation on the one hand and the values of an institution on the other hand can be expected. The intention of initiation usually is to prepare one for a position or rote by means of the expression of certain values. On the question whether this harmony between ideas and actions is found in the case of existent initiation ceremonies at South African universities, the answer is negative. These ceremonies do not aim to convey and develop attitudes and values essential to a university and in fact do not prepare first-year students for their new environment and a community of scholars. The way in which universities transcend their authority by condoning and officially allowing the demeaning initiation practices is also questioned.

SaudiVeg ecoinformatics: Aims, current status and perspectives

Directory of Open Access Journals (Sweden)

Mohamed A. El-Sheikh

2017-02-01

Full Text Available During the last decade many electronic databases of vegetation plots were established in many countries around the world. These databases contain valuable phytosociological information assisting both governmental and NGO (Non-governmental organizations agencies to formulate strategies and on-ground plans to manage and protect nature resources. This paper provides an account on aims, current status and perspectives of building of a vegetation database for the Central Region (Najd of Saudi Arabia – the founding element of the Saudi Vegetation Database (SVD. The data stored by the database are sample plots (vegetation relevés collected according to the field techniques of the Braun-Blanquet approach (lists of taxa accompanied by semi-quantitative cover assessment, and are accompanied by general vegetation characteristics such as vegetation layering and cover, information on life-form of the recorded species, geographical coordinates, altitude, soil typology, topography and many more. More than 2900 vegetation-plot records (relevés have so far been collected in the Najd region; of these more than 2000 have already been stored using the Turboveg database platform. These field records cover many habitats such as depressions, wadis (dry river beds, agricultural lands, sand dunes, sabkhas, and ruderal habitats. The ecological information collected in the database is currently the largest set of vegetation data collated into a database in the Middle East. These data are of great importance for biodiversity studies in Saudi Arabia, since the region is recording a loss of biodiversity at a fast rate due to environmental problems such as global warming and land-use changes. We envisage that this database would catalyze further data collection on vegetation of the entire Arabian Peninsula, and shall serve as one of the most important datasets for classification and mapping of the vegetation of the Kingdom of Saudi Arabia.

Efficacy comparison of duloxetine and SSRIs at doses approved in Japan

Directory of Open Access Journals (Sweden)

Harada E

2015-01-01

Full Text Available Eiji Harada,1 Alexander Schacht,2 Tsukasa Koyama,3 Lauren Marangell,4,5 Toshinaga Tsuji,6 Rodrigo Escobar41Medical Science, Eli Lilly Japan K.K, Kobe, Japan; 2Global Statistical Sciences, Eli Lilly and Company, Bad Homburg, Germany; 3Clinical Research Center, Ohyachi Hospital, Sapporo, Japan; 4Eli Lilly and Company, Indianapolis, IN, 5The University of Texas Health Science Center, Houston, TX, USA; 6Medical Affairs, Shionogi & Co Ltd, Osaka, JapanBackground: Approved doses of antidepressants in Japan are usually lower than those in the USA and European Union, but to date meta-analyses comparing antidepressants have all used the higher doses approved in the USA and European Union and often have used indirect comparisons. The purpose of this study was to conduct an integrated database analysis of patient level data to compare the effects of duloxetine with those of selective serotonin reuptake inhibitors (SSRIs at the doses approved in Japan.Methods: Pooled data were analyzed from four randomized, double-blind, placebo-controlled studies that compared duloxetine at the dose range approved in Japan (40–60 mg/day with other SSRIs (paroxetine 20 mg/day or escitalopram 10 mg/day and placebo in patients with major depressive disorder. In total, 1,694 patients were included in the analysis (duloxetine, n=688; selective serotonin reuptake inhibitors, n=690; placebo, n=316. The primary outcome measure was the mean change from baseline at week 8 in 17-item Hamilton Rating Scale for Depression (HAMD17 total and subscale scores.Results: Duloxetine and both selective serotonin reuptake inhibitors were superior to placebo in HAMD17 total score at week 8 in both the all-randomized group and the more severe subgroup (HAMD17 total scores ≥19. Duloxetine was superior to SSRIs in improving the HAMD17 Retardation subscale score (least squares mean difference [95% confidence interval]: all-randomized group, −0.33 [−0.60, −0.07], P=0.015; severe subgroup, �

Estimating the real world daily usage and cost for exenatide twice daily and liraglutide in Germany, the Netherlands, and the UK based on volumes dispensed by pharmacies

Directory of Open Access Journals (Sweden)

McDonell AL

2015-01-01

Full Text Available Amanda L McDonell,1 Urpo Kiiskinen,2 Danielle C Zammit,3 Robert W Kotchie,1 Per-Olof Thuresson,3 Claudia Nicolay,4 Thomas Haslam,1 Michiel Bruinsma,5 Anne-Jeanine Janszen-Van Oosterhout,6 Thorsten Otto41IMS Health, London, UK; 2Eli Lilly and Company, Helsinki, Finland; 3IMS Health, Basel, Switzerland; 4Eli Lilly and Company, Bad Homburg, Germany; 5IMS Health, Rotterdam, the Netherlands; 6Eli Lilly Nederland, Houten, the NetherlandsBackground: Glucagon-like peptide-1 (GLP-1 receptor agonists are indicated for improvement of glycemic control in adults with type 2 diabetes. Cost is one aspect of treatment to be considered, in addition to clinical benefits, when selecting optimal therapy for a patient. The objective of this study was to estimate the average dose usage and real world daily cost of the GLP-1 receptor agonists, exenatide twice daily and liraglutide once daily, in Germany, the Netherlands, and the UK.Methods: Administrative databases were used to source the data from longitudinal records of dispensed prescriptions. Data were extracted from the IMS Longitudinal Prescription database which captures details of prescriptions dispensed in pharmacies. Information on the dispensed quantity of each product was used to estimate average daily usage per patient. Daily dose usage was multiplied by the public price per unit to estimate daily cost.Results: The dispensed volume in Germany corresponded to a mean dispensed daily dose of 16.81 µg for exenatide twice daily and 1.37 mg for liraglutide (mean daily cost €4.02 and €4.54, respectively. In the Netherlands, average dispensed daily doses of 17.07 µg and 1.49 mg were observed for exenatide twice daily and liraglutide (mean daily cost €3.05 and €3.97, respectively. In the UK, the mean dispensed volume corresponded to a daily usage of 20.49 µg for exenatide twice daily and 1.50 mg for liraglutide (mean daily cost £2.53 and £3.28, respectively.Conclusion: Estimates of average daily

Complementary coordination strategies in a joint Fitts’ reciprocal aiming task

DEFF Research Database (Denmark)

Konvalinka, Ivana; Skewes, Lea; Michael, J.

How do dyads coordinate their actions to achieve a common goal when one person has the more difficult task? In the present study, dyads were instructed to engage in a Fitts’s reciprocal aiming task as accurately as possible, and at a given tempo sent through their headphones. They were in conditi...... a joint goal, by taking on leader-follower roles....... was assigned to either the target’s role – with varying target width, and hence task difficulty – or the reference role – with the widest (easiest) target. Results show that when the task was performed interactively with the other person, they were most synchronized, and also used the target most similarly......, while compromising rhythmic accuracy. In addition, as task difficulty increased for the member with the target’s role, the participant with the reference role became more adaptive to her tempo. This suggests that interacting members of a dyad optimally negotiate coordination strategies to achieve...

Cross-cultural exchange: How students can frustrate the aims of study abroad programmes

Science.gov (United States)

Barnes, Leslie R.

1982-09-01

Readily accepting that study abroad programmes may have as many differing forms and aims as there are participating institutions, and that by no means all programmes include academic content in their goals, I would nevertheless maintain: 1. that a sociological perspective is as necessary as the hitherto predominantly psychological approach in obtaining a balanced assessment of study abroad programmes;

AIM-9X Block II Sidewinder (AIM-9X Blk II)

Science.gov (United States)

2015-12-01

awarded the System Improvement Program III ( SIP III) contract in September 2015 to improve missile performance, address obsolescence and to implement cost...Authorization to Operate IEA - Information Enterprise Architecture in - Inches IP - Internet Protocol IT - Information Technology JTRS - Joint Test

Slashsing the Invisible

DEFF Research Database (Denmark)

Westberg, Lysa Hannah Pernille Nielsen

2018-01-01

in which one or more main characters were asexual grew (Fanfiction.net, AO3, 2016). Like with other fanfiction, asexuality fanfiction's authors also entered into this argument with the normative. Desire is regulated, medicated and controlled. (Foucault, Spurgas, 2016) Society regards sex as performance...... fanfiction becomes a discussion with a society in which the medicalized lust and the expected performance of sex is the norm. Asexuality-themed fics might be where we find masculinity is questioned and redefined as well; society's view on male sexuality rarely includes the view of male sexual attraction....... In order to investigate the themes of bodily autonomy and relationships, a broad selection of the approximately 6,000 asexuality-themed fanfics on Fanfiction.net and Archive of Our Own (AO3, Fanfiction.net, 2016) is analysed to determine how authors describe asexuality (crack, kink or realistically), how...

The neuroendocrinology of love

Directory of Open Access Journals (Sweden)

Krishna G Seshadri

2016-01-01

Full Text Available Romantic love could be considered as a collection of activities associated with the acquisition and retention of emotions needed to survive and reproduce. These emotions change the individual's behavioural strategies in a way that will increase the likelihood of achieving these goals. Love may be defined as an emergent property of an ancient cocktail of neuropeptides and neurotransmitters. It appears that lust, attachment and attraction appear to be distinct but intertwined processes in the brain each mediated by its own neurotransmitters and circuits. These circuits feed on and reinforce each other. Sexual craving is mediated by testosterone and oestrogen and has the amygdala as an important centre. Attraction is mediated by hormones of stress and reward including dopamine, norepinephrine cortisol and the serotinergic system and has the nucleus accumbens the ventral tegmental area as key mediators.

The team responsible for testing and measuring the LHC insertion quadrupoles

CERN Multimedia

Patrice Loïez

2003-01-01

The LHC main magnet system includes about 600 superconducting quadrupoles for beam focusing. Superconducting Matching Quadrupole Magnets (MQMs) are just one of several varieties of quadrupole; they will be installed in the accelerator´s eight ´insertion zones´, four of which are also experimental areas, where the beams will intersect to produce proton-proton collisions. The first MQM, built by the UK firm Tesla Engineering, has passed its acceptance tests. The team responsible for the tests is pictured here with the 3.5-metre-long magnet. Photo 01: Bottom row, left to right, Michäel Ky, Antoine Dias Goncalves, Gilles Rittaud, Yannick Riva; middle row, left to right, Vladimir Bretin, Noël Dalexandro, Bert Lust, Patrick Viret; top row, left to right, Christian Giloux, Ranko Ostojic, Walter Venturini Delsolaro, Lassaâd Gharsallah.

The relationship between pain severity and patient-reported outcomes among patients with chronic low back pain in Japan

Directory of Open Access Journals (Sweden)

Montgomery W

2016-06-01

Full Text Available William Montgomery,1 Jeffrey Vietri,2 Jing Shi,3 Kei Ogawa,4 Sawako Kariyasu,4 Levent Alev,4 Masaya Nakamura5 1Eli Lilly Australia Pty Ltd., Sydney, NSW, Australia; 2Health Outcomes Practice, Kantar Health, Horsham, PA, 3Health Outcomes Practice, Kantar Health, Princeton, NJ, USA; 4Eli Lilly Japan K.K., Kobe, Japan; 5Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan Objective: The aim of this study was to quantify the impact of pain severity on patient-reported outcomes among individuals diagnosed with chronic low back pain in Japan. Methods: Data were provided by the 2012 Japan National Health and Wellness Survey (N=29,997, a web-based survey of individuals in Japan aged ≥18 years. This analysis included respondents diagnosed with low back pain of ≥3-month duration. Measures included the revised Medical Outcomes Study 36-Item Short-Form Survey Instrument, the Patient Health Questionnaire-9, the Generalized Anxiety Disorder-7 scale, the Work Productivity and Activity Impairment: General Health questionnaire, and self-reported all-cause health care visits (6 months. Generalized linear models were used to assess the relationship between outcomes and severity of pain in the past week as reported on a numeric rating scale ranging from 0 (no pain to 10 (pain as bad as you can imagine, controlling for length of diagnosis, sociodemographics, and general health characteristics. Results: A total of 290 respondents were included in the analysis; mean age was 56 years, 41% were females, and 56% were employed. Pain severity was 3/10 for the first quartile, 5/10 for the median, and 7/10 for the third quartile of this sample. Increasing severity was associated with lower scores for mental and physical component summaries and Short-Form 6D health utility, higher depression (Patient Health Questionnaire-9 and anxiety (Generalized Anxiety Disorder-7 scores, greater absenteeism and presenteeism, greater activity impairment

An Economic Aspect of the AVOID Programme: Analysis Using the AIM/CGE Model

Science.gov (United States)

Matsumoto, Ken'ichi; Masui, Toshihiko

2010-05-01

This presentation purposes to show the results of the analysis that the AIM/CGE [Global] model contributed to Work Stream 1 of the AVOID programme. Three economic models participate in this WS to analyze the economic aspects of defined climate policies, and the AIM/CGE [Global] model is one of them. The reference scenario is SRES A1B and five policy scenarios (2016.R2.H, 2016.R4.L, 2016.R5.L, 2030.R2.H, and 2030.R5.L) are considered. The climate policies are expressed as emissions pathways of several gases such as greenhouse gases and aerosols. The AIM/CGE [Global] model is a recursive dynamic global CGE model with 21 industrial sectors and 24 world regions. These definitions are based on the GTAP6 database and it is used as the economic data of the base year. Some important characteristics of this model can be summarized as follows: power generation by various sources (from non-renewables to renewables) are considered; CCS technology is modeled; biomass energy (both traditional and purpose-grown) production and consumption are included; not only CO2 emissions but also other gases are considered; international markets are modeled for international trade of some fossil fuels; relationships between the costs and resource reserves of fossil fuels are modeled. The model is run with 10-year time steps until 2100. For the reference case, there are no constraints and the model is run based on the drivers (assumptions on GDP and population for A1B) and AEEI. The reference case does not have the same emissions pathways as the prescribed emissions for A1B in AVOID. For scenario cases, the model is run under emissions constraints. In particular, for each policy scenario, the constraint on each gas in each 10-year step is derived. The percentage reduction in emissions that occurs between the AVOID A1B scenario and the particular policy scenario, for each gas in each 10-year period is first calculated, and then these percentage reductions are applied to the AIM reference case

[Steps aimed at upgrading a pharmaceutical care sector: the case of surgery].

Science.gov (United States)

Guérin, A; Thibault, M; Nguyen, C; Lebel, D; Bussières, J-F

2014-07-01

While the concept of clinical pharmacy was developed in the 1960s, clinical programs are characterized by their great variety and disparity when it comes to the presence of pharmacists in healthcare sectors. This article aims to describe a method in which pharmaceutical care sectors in healthcare facilities can be upgraded. This is a descriptive study supporting the upgrade of pharmaceutical care practiced in the surgery sector of a 500-bed mother-child university hospital center, the CHU Sainte-Justine. The pharmacy department employs more than 70 healthcare professionals. The study involved these proposed upgrading steps: firstly, a review of the literature; secondly, a description of the profile of the sector; thirdly, a description of the upgrading of pharmacist practice in surgery. A total of 137 articles were compiled, seven of which were selected to evaluate the impact and eight a description of the pharmacist's role in surgery. The authors did not identify any particular pharmaceutical activity based on very good quality data (A). However, there were five based on good quality data (B) and seven that lacked adequate proof (C, D) in relation to the practice of surgery. Nevertheless, a number of other authors described the development of the pharmacist's clinical role in surgery. There are few data on the impact of pharmacists in surgery. This descriptive study proposes a number of steps aimed at upgrading pharmaceutical care within a Quebec university hospital center. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Aims and tasks in parental caregiving for children receiving palliative care at home: a qualitative study.

Science.gov (United States)

Verberne, Lisa M; Kars, Marijke C; Schouten-van Meeteren, Antoinette Y N; Bosman, Diederik K; Colenbrander, Derk A; Grootenhuis, Martha A; van Delden, Johannes J M

2017-03-01

In paediatric palliative care (PPC), parents are confronted with increasing caregiving demands. More children are cared for at home, and the need for PPC of children is lengthened due to technical and medical improvements. Therefore, a clear understanding of the content of parental caregiving in PPC becomes increasingly important. The objective is to gain insight into parental caregiving based on the lived experience of parents with a child with a life-limiting disease. An interpretative qualitative study using thematic analysis was performed. Single or repeated interviews were undertaken with 42 parents of 24 children with a malignant or non-malignant disease, receiving PPC. Based on their ambition to be a 'good parent', parents caring for a child with a life-limiting disease strived for three aims: controlled symptoms and controlled disease, a life worth living for their ill child and family balance. These aims resulted in four tasks that parents performed: providing basic and complex care, organising good quality care and treatment, making sound decisions while managing risks and organising a good family life. Parents need early explanation from professionals about balancing between their aims and the related tasks to get a grip on their situation and to prevent becoming overburdened. What is Known: • In paediatric palliative care, parents are confronted with increasing caregiving demands. • Parenting is often approached from the perspective of stress. What is New: • Parents strive for three aims: controlled symptoms and controlled disease, a life worth living for their child and family balance. • Parents perform four tasks: providing basic and complex care, organising good quality care, making decisions while managing risks and organising a good family life. • Professionals need insight into the parents' aims and tasks from the parental perspective to strengthen parents' resilience.

Engineering strategies aimed at control of acidification rate of lactic acid bacteria

DEFF Research Database (Denmark)

Martinussen, Jan; Solem, Christian; Holm, Anders Koefoed

2013-01-01

The ability of lactic acid bacteria to produce lactic acid from various sugars plays an important role in food fermentations. Lactic acid is derived from pyruvate, the end product of glycolysis and thus a fast lactic acid production rate requires a high glycolytic flux. In addition to lactic acid......, alternative end products - ethanol, acetic acid and formic acid - are formed by many species. The central role of glycolysis in lactic acid bacteria has provoked numerous studies aiming at identifying potential bottleneck(s) since knowledge about flux control could be important not only for optimizing food...

Teaching portfolios and a competence framework aimed to build faculty teaching competencies

DEFF Research Database (Denmark)

Dolin, Jens; Kobayashi, Sofie

as a need for a common language and reference. Main barriers are scepticism towards the teaching portfolio for assessment of competencies, fear of extra work load, possible use as control measures, and fear that standards will narrow teaching development. In a research intensive university it is very......The University of Copenhagen has decided to introduce teaching portfolios and a competence framework as initiatives aimed to address the relatively low status of teaching compared to research. The two measures have been designed in a bottom-up process and are also backed by university leadership...

Development of AIM for analysing policy options to reduce greenhouse gas emissions

International Nuclear Information System (INIS)

Kainuma, M.; Morita, T.; Matsuoka, Y.

1999-01-01

AIM (Asian-Pacific Integrated Model) has been developed for predicting greenhouse gas emissions and evaluating policy measures to reduce them. Two socio-economic scenarios were assumed and CO 2 emissions were predicted based on these scenarios and policy intervention assumptions. It is found that mitigating CO 2 emissions without scaling back productive activities or standards of living in Japan is possible. However, if one relies on the market mechanism alone, it cannot be done. The analysis has shown that it is essential to introduce new policies and measures such as carbon tax and subsidies. (author)

The Advanced Industrial Materials (AIM) program office of industrial technologies fiscal year 1995

Energy Technology Data Exchange (ETDEWEB)

Sorrell, C.A.

1997-04-01

In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in FY95 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven `Vision Industries` that use about 80% of industrial energy and generated about 90% of industrial wastes. These are: aluminium; chemical; forest products; glass; metal casting; refineries; and steel. OIT is working with these industries, through appropriate organizations, to develop Visions of the desired condition of each industry some 20 to 25 years in the future and then to prepare Road Maps and Implementation Plans to enable them to reach their goals. The mission of AIM has, therefore, changed to `Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`

Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants

NARCIS (Netherlands)

Samoocha, D.; Snels, I.A.K.; Bruinvels, D.J.; Anema, J.R.; Kowalczyk, W.J.; van der Beek, A.J.

2011-01-01

Background: The objective of this process evaluation study was to gain insight into the reach, compliance, appreciation, usage barriers, and users' perceived effectiveness of a web-based intervention http://www.wiagesprek.nl. This intervention was aimed at empowerment of disability claimants, prior

Process Evaluation of an Occupational Health Guideline Aimed at Preventing Weight Gain Among Employees

NARCIS (Netherlands)

Verweij, Lisanne M.; Proper, Karin I.; Hulshof, Carel T. J.; van Mechelen, Willem

2011-01-01

Objective: To evuate the process of an occupational health guideline aimed at preventing weight gain. Methods: Quantitative data on seven process items were assessed and linked to effects on employees' waist circumference and body weight at 6 months. Results: Occupational physicians (n = 7)

An exploration in kitchen blender interactions aimed at designing for high levels of engagement

NARCIS (Netherlands)

van Rheden, V.; Hengeveld, B.J.

2015-01-01

This paper illustrates three novel kitchen blender interactions aimed at bringing about a higher level of engagement with interactive products, as a response to current, seemingly un-engaging interactions. We describe our starting points and approach after which we present the designed blender

Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants

NARCIS (Netherlands)

Samoocha, David; Snels, Ingrid A. K.; Bruinvels, David J.; Anema, Johannes R.; Kowalczyk, Wojtek; van der Beek, Allard J.

2011-01-01

The objective of this process evaluation study was to gain insight into the reach, compliance, appreciation, usage barriers, and users' perceived effectiveness of a web-based intervention http://www.wiagesprek.nl. This intervention was aimed at empowerment of disability claimants, prior to the

Controlled austempering of hammer forgings aimed at pseudo normalized microstructure directly after deformation

Directory of Open Access Journals (Sweden)

P. Skubisz

2017-01-01

Full Text Available The study concerns cost-effective realization of controlled thermomechanical processing (CTMP of medium-carbon and HSLA steel aimed at producing microstructure and properties equivalent to normalized condition directly after forging. The results of theoretical and physical modeling of hot forging with subsequent heat treating adopted for industrial realization in continuous manner were verified in semi-industrial conditions of a forge plant.

SU-E-T-531: Large--Scale DVH Quality Study: Correlated Aims Lead Relaxations

Energy Technology Data Exchange (ETDEWEB)

Nohadani, O; Roy, A [Northwestern University, Evanston, IL (United States); Das, I [Indiana University- School of Medicine, Indianapolis, IN (United States)

2015-06-15

Purpose: Intensity modulated radiation therapy plans are designed to optimally target a tumor while sparing surrounding tissue. Desired dose distributions are iteratively approached via inverse planning. This leads to tradeoffs between clinical objectives for the planning target volume (PTV), organs at risk, and normal tissues. Dose volume histogram (DVHs) related aims are followed that are either institutional or internationally recommended. We analyze common goals and identify potential reasons that often lead to tradeoffs. Methods: 524 IMRT plans for various tumor sites were analyzed based on the main institutional DVH goal for PTV (D95) and the recommendations by ICRU-83 (D2, D50, and D98). Robust statistical tools are developed and applied to ensure that the results are immune to data uncertainties. The probability of violation was measured for each of the DVH goals based on the frequency of not meeting recommended doses. Conditional probabilities for satisfying and/or violating DVH aims were computed to test the hypothesized pair-wise relations between DVH aims. For example, for plans that satisfied D50, the probability of violating D98 was computed via P(D98 < 95% | 98% ≤ D50 ≤ 102%). The equality constraint D50 = 100% was relaxed to encompass the range [98,102]%. Results: A large majority of cases (88%) satisfied the institutional goal for PTV of D95 ≤ 95%. Similar consensus existed for D98. 51% of cases satisfied D2 ≥ 107%. However, only 18% of cases satisfied D50. The conditional probability showed correlations amongst the studied DVH goals. In fact, a negative correlation was revealed between D50 and D95 (and D98), suggesting that these competing goals cannot be satisfied concurrently. Conclusion: The majority of plans followed the institutional guidelines. The reason for their deviation from international recommendations seems to be that the latter goals are competing and cannot be satisfied concurrently in clinical practice.

The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection.

Science.gov (United States)

Marim, Fernanda M; Franco, Miriam M Costa; Gomes, Marco Tulio R; Miraglia, Maria Cruz; Giambartolomei, Guillermo H; Oliveira, Sergio C

2017-02-01

The innate immune system is essential for the detection and elimination of bacterial pathogens. Upon inflammasome activation, caspase-1 cleaves pro-IL-1β and pro-IL-18 to their mature forms IL-1β and IL-18, respectively, and the cell undergoes inflammatory death termed pyroptosis. Here, we reviewed recent findings demonstrating that Brucella abortus ligands activate NLRP3 and AIM2 inflammasomes which lead to control of infection. This protective effect is due to the inflammatory response caused by IL-1β and IL-18 rather than cell death. Brucella DNA is sensed by AIM2 and bacteria-induced mitochondrial reactive oxygen species is detected by NLRP3. However, deregulation of pro-inflammatory cytokine production can lead to immunopathology. Nervous system invasion by bacteria of the genus Brucella results in an inflammatory disorder termed neurobrucellosis. Herein, we discuss the mechanism of caspase-1 activation and IL-1β secretion in glial cells infected with B. abortus. Our results demonstrate that the ASC inflammasome is indispensable for inducing the activation of caspase-1 and secretion of IL-1β upon infection of astrocytes and microglia with Brucella. Moreover, our results demonstrate that secretion of IL-1β by Brucella-infected glial cells depends on NLRP3 and AIM2 and leads to neurobrucellosis. Further, the inhibition of the host cell inflammasome as an immune evasion strategy has been described for bacterial pathogens. We discuss here that the bacterial type IV secretion system VirB is required for inflammasome activation in host cells during infection. Taken together, our results indicate that Brucella is sensed by ASC inflammasomes mainly NLRP3 and AIM2 that collectively orchestrate a robust caspase-1 activation and pro-inflammatory response.

Fluency: an aim in teaching and a criterion in assessment

Directory of Open Access Journals (Sweden)

Aud Marit Simensen

2010-05-01

Full Text Available This article investigates the concept ‘fluency’ from different perspectives. When fluency is an aim in teaching, a thorough comprehension of the concept among teachers is a prerequisite for appropriate planning of instruction, including the choice of appropriate classroom activities. When fluency is an assessment criterion, it is even more important that examiners have a shared perception of the concept. The present article starts by presenting common perceptions of the concept and goes on to explore some of the current research. Next, it provides a historical overview of the place of fluency in teaching theory and explains some of the preconditions for the inclusion of this concept among teaching objectives and assessment criteria. It will also, as an illustration, give an outline of the position of the concept over time in the Norwegian school system on the basis of an analysis of the relevant syllabuses. Finally, the article explicates the notion of language use as a complex cognitive skill and explores current method¬ological ideas about teaching towards fluency.

Ecolabel and ecodesign. Aims impossible for small and medium companies?

International Nuclear Information System (INIS)

Luciani, R.; Andriola, L.; Masoni, P.

2000-01-01

It is commonly held by now that a policy of sustainable development in the production sector cannot be faced in terms of simply reducing the environmental impact at the end of the production chain but should be imprinted with a preventive approach which, intervening on the production cycles and the products themselves, helps minimize pressure on the environment. To be competitive manufacturing industry must contribute a determinant amount to sustainable development by reducing the material content of products and increasing their use value, through processes and products-services that are innovative, safer, cleaner and based on a low use of natural resources. To be effective and avoid merely shifting the problem, this work should not be aimed at the level of individual plants or industries but be broadly planned, taking into account the entire value chain and hence the product's whole life-cycle. In addition, support should be given to small and medium-sized companies that characterize Italian production, because they find it hard to use the tools of a product policy originally ideated for big business [it

20 years TraumaRegister DGU(®): development, aims and structure.

Science.gov (United States)

2014-10-01

The TraumaRegister DGU(®) organisational and technical development has undergone an evolution process, which started 20 years ago. Currently, the management of the registry is under the management of the "AUC - Academy for Trauma Surgery" (infrastructure) and the "Sektion NIS" (scientific responsibility). The aim of the registry was to establish an inter-hospital quality assessment tool with the option to use the increasing database for scientific evaluations of acute care. Year after year and most recently with the obligatory participation of certified hospitals the number of participating hospitals has grown as well as the registered cases per annum. Recently, even hospitals from other countries joined the registry too. Starting with six German hospitals and 260 cases in 1993, 20 years later more than 600 hospitals from eleven countries deliver over 30,000 trauma cases per year resulting in over 150,000 reported cases until 2013. In this article a historical perspective is presented of the evolution and current status of the TraumaRegister DGU(®). Copyright © 2014 Elsevier Ltd. All rights reserved.

Empowering employees with chronic diseases: process evaluation of an intervention aimed at job retention

NARCIS (Netherlands)

Varekamp, Inge; Krol, Boudien; van Dijk, Frank J. H.

2011-01-01

Purpose Employees with a chronic disease may experience work-related problems that contribute to the risk of job loss. We developed a group-based intervention programme aimed at clarifying problems, making these a subject of discussion at work, and realizing solutions. This process evaluation

Empowering employees with chronic diseases : process evaluation of an intervention aimed at job retention

NARCIS (Netherlands)

Varekamp, Inge; Krol, Boudien; van Dijk, Frank J. H.

Purpose Employees with a chronic disease may experience work-related problems that contribute to the risk of job loss. We developed a group-based intervention programme aimed at clarifying problems, making these a subject of discussion at work, and realizing solutions. This process evaluation

New missions aim to make a short list of exo-Earths

Science.gov (United States)

Clery, Daniel

2018-03-01

Thanks to NASA's pioneering Kepler probe, we know our galaxy is teeming with exoplanets. Now, a new generation of exoplanet hunters is set to home in on rocky worlds closer to home. Over 9 years in space, Kepler has found more than 2600 confirmed exoplanets. The new efforts sacrifice sheer numbers and target Earth-size planets whose composition, atmosphere, and climate—factors in whether they might be hospitable to life—could be probed. Leading the charge is the Transiting Exoplanet Survey Satellite (TESS), a NASA mission due for launch on 16 April. The $337 million TESS project aims to identify at least 50 rocky exoplanets—Earth-size or bigger—close enough for their atmospheres to be scrutinized by the much larger James Webb Space Telescope, due for launch in 2020.

Factors influencing the design of aiming devices for intraoral radiography and their practical application

NARCIS (Netherlands)

Aken, J. van; Verhoeven, J.W.

Intraoral roentgenograms can be made according to the long-tube paralleling technique utilizing aiming devices. These instruments consist of a bite block, an indicator rod, and a collimator plate. For the position of the film in relation to the bite block surface, the following data are decisive and

To report or not to report: a psychosocial investigation aimed at improving early detection of Avian Influenza outbreaks

NARCIS (Netherlands)

A.R.W. Elbers; M.J. Gorgievski-Duijvesteijn (Marjan); K. Zarafshani (Kiumars); G. Koch (Guus)

2010-01-01

textabstractSummary: The aim of this study was to identify difficulties and barriers to reporting clinically suspect situations, possibly caused by avian influenza (AI), and to explore possible incentives to reporting such situations, with the ultimate aim of facilitating early detection of AI

Spiritual AIM and the work of the chaplain: a model for assessing spiritual needs and outcomes in relationship.

Science.gov (United States)

Shields, Michele; Kestenbaum, Allison; Dunn, Laura B

2015-02-01

Distinguishing the unique contributions and roles of chaplains as members of healthcare teams requires the fundamental step of articulating and critically evaluating conceptual models that guide practice. However, there is a paucity of well-described spiritual assessment models. Even fewer of the extant models prescribe interventions and describe desired outcomes corresponding to spiritual assessments. This article describes the development, theoretical underpinnings, and key components of one model, called the Spiritual Assessment and Intervention Model (Spiritual AIM). Three cases are presented that illustrate Spiritual AIM in practice. Spiritual AIM was developed over the past 20 years to address the limitations of existing models. The model evolved based in part on observing how different people respond to a health crisis and what kinds of spiritual needs appear to emerge most prominently during a health crisis. Spiritual AIM provides a conceptual framework for the chaplain to diagnose an individual's primary unmet spiritual need, devise and implement a plan for addressing this need through embodiment/relationship, and articulate and evaluate the desired and actual outcome of the intervention. Spiritual AIM's multidisciplinary theory is consistent with the goals of professional chaplaincy training and practice, which emphasize the integration of theology, recognition of interpersonal dynamics, cultural humility and competence, ethics, and theories of human development. Further conceptual and empirical work is needed to systematically refine, evaluate, and disseminate well-articulated spiritual assessment models such as Spiritual AIM. This foundational work is vital to advancing chaplaincy as a theoretically grounded and empirically rigorous healthcare profession.

Development, implementation and critique of a bioethics framework for pharmaceutical sponsors of human biomedical research.

Science.gov (United States)

Van Campen, Luann E; Therasse, Donald G; Klopfenstein, Mitchell; Levine, Robert J

2015-11-01

Pharmaceutical human biomedical research is a multi-dimensional endeavor that requires collaboration among many parties, including those who sponsor, conduct, participate in, or stand to benefit from the research. Human subjects' protections have been promulgated to ensure that the benefits of such research are accomplished with respect for and minimal risk to individual research participants, and with an overall sense of fairness. Although these protections are foundational to clinical research, most ethics guidance primarily highlights the responsibilities of investigators and ethics review boards. Currently, there is no published resource that comprehensively addresses bioethical responsibilities of industry sponsors; including their responsibilities to parties who are not research participants, but are, nevertheless key stakeholders in the endeavor. To fill this void, in 2010 Eli Lilly and Company instituted a Bioethics Framework for Human Biomedical Research. This paper describes how the framework was developed and implemented and provides a critique based on four years of experience. A companion article provides the actual document used by Eli Lilly and Company to guide ethical decisions regarding all phases of human clinical trials. While many of the concepts presented in this framework are not novel, compiling them in a manner that articulates the ethical responsibilities of a sponsor is novel. By utilizing this type of bioethics framework, we have been able to develop bioethics positions on various topics, provide research ethics consultations, and integrate bioethics into the daily operations of our human biomedical research. We hope that by sharing these companion papers we will stimulate discussion within and outside the biopharmaceutical industry for the benefit of the multiple parties involved in pharmaceutical human biomedical research.

Efficacy and Safety Extrapolation Analyses for Atomoxetine in Young Children with Attention-Deficit/Hyperactivity Disorder.

Science.gov (United States)

Upadhyaya, Himanshu; Kratochvil, Christopher; Ghuman, Jaswinder; Camporeale, Angelo; Lipsius, Sarah; D'Souza, Deborah; Tanaka, Yoko

2015-12-01

This extrapolation analysis qualitatively compared the efficacy and safety profile of atomoxetine from Lilly clinical trial data in 6-7-year-old patients with attention-deficit/hyperactivity disorder (ADHD) with that of published literature in 4-5-year-old patients with ADHD (two open-label [4-5-year-old patients] and one placebo-controlled study [5-year-old patients]). The main efficacy analyses included placebo-controlled Lilly data and the placebo-controlled external study (5-year-old patients) data. The primary efficacy variables used in these studies were the ADHD Rating Scale-IV Parent Version, Investigator Administered (ADHD-RS-IV-Parent:Inv) total score, or the Swanson, Nolan and Pelham (SNAP-IV) scale score. Safety analyses included treatment-emergent adverse events (TEAEs) and vital signs. Descriptive statistics (means, percentages) are presented. Acute atomoxetine treatment improved core ADHD symptoms in both 6-7-year-old patients (n=565) and 5-year-old patients (n=37) (treatment effect: -10.16 and -7.42). In an analysis of placebo-controlled groups, the mean duration of exposure to atomoxetine was ∼ 7 weeks for 6-7-year-old patients and 9 weeks for 5-year-old patients. Decreased appetite was the most common TEAE in atomoxetine-treated patients. The TEAEs observed at a higher rate in 5-year-old versus 6-7-year-old patients were irritability (36.8% vs. 3.6%) and other mood-related events (6.9% each vs. atomoxetine may improve ADHD symptoms, but possibly to a lesser extent than in older children, with some adverse events occurring at a higher rate in 5-year-old patients.

Correlation between pain response and improvements in patient-reported outcomes and health-related quality of life in duloxetine-treated patients with diabetic peripheral neuropathic pain

Directory of Open Access Journals (Sweden)

Ogawa K

2015-08-01

Full Text Available Kei Ogawa,1 Shinji Fujikoshi,2 William Montgomery,3 Levent Alev1 1Medical Science, 2Statistical Science, Eli Lilly Japan K.K., Kobe, Japan; 3Global Patient Outcomes and Real World Evidence, Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia Objective: We assessed whether quality of life (QoL improvement in duloxetine-treated patients with diabetic peripheral neuropathic pain (DPNP correlates with the extent of pain relief.Methods: Pooled data from three multicountry, double-blind, 12-week, placebo-controlled trials of duloxetine-treated (duloxetine 60 mg once daily; total number =335 patients with DPNP were analyzed. Based on improvement in 24-hour average pain scores, patients were stratified into four groups. Improvement in QoL, which was measured as the change from baseline in two patient-reported health outcome measures (Short Form [SF]-36 and five-dimension version of the EuroQol Questionnaire [EQ-5D], was evaluated and compared among the four groups. Pearson’s correlation coefficient was calculated to assess the correlation between improvement in pain scores and improvement in QoL.Results: The group with more pain improvement generally showed greater mean change from baseline in all of the SF-36 scale scores and on the EQ-5D index. Pearson’s correlation coefficients ranged from 0.114 to 0.401 for the SF-36 scale scores (P<0.05, and it was 0.271 for the EQ-5D (P<0.001.Conclusion: Improvement in pain scores was positively correlated with improvement in QoL and patient-reported outcomes in duloxetine-treated patients. Keywords: diabetic peripheral neuropathic pain, duloxetine, efficacy, function, quality of life

To report or not to report: a psychosocial investigation aimed at improving early detection of avian influenza outbreaks

NARCIS (Netherlands)

Elbers, A.R.W.; Gorgievski, M.J.; Zarafshani, K.; Koch, G.

2010-01-01

The aim of this study was to identify limitations - and solutions for those limitations – with respect to reporting clinically suspect situations on poultry farms, possibly caused by Avian Influenza (AI) with the ultimate aim to facilitate early detection of AI-outbreaks. Focus group sessions were

A Correlational and Descriptive Study of Student Writing in Three Aims of Discourse.

Science.gov (United States)

1981-12-01

than the old abondend house does now. As it stands it is the perfect target and meeting place for criminals and drug addicts . If the house were C... Whale and Robinson (1978) discovered that, in a free-writing situation, students most often chose to write transactional (referential and persuasive...discourse.27 (Perhaps in the transactional aim they used the narrative mode more than any other, as Pianko’s study suggested, but Whale and Robinson did

NEURO-SYSTEM OF AIMING AND STABILIZING WITH A REGULATOR ON THE BASIS OF STANDARD MODEL MODEL REFERENCE CONTROLLER

Directory of Open Access Journals (Sweden)

B.I. Kuznetsov

2015-08-01

Full Text Available The aim of this work is the synthesis of neural network aiming and stabilization system for the special equipment of moving objects with neuro-controller on the basis of standard model and performance comparison of the neural network system with the neural network predictive control. Build a block diagram of the neural network aiming and stabilization system, based on the subject control principle with PD-regulator in the position loop and with neuro-controller on the basis of standard model in the in the velocity loop. The neuro-controller on the basis of standard model Model Reference Controller is synthesized in the MATLAB Neural Network Toolbox and system simulation is performed. The studies show that the transient state variables of the system are oscillatory. Therefore, the neuro-controller with the prediction NN Predictive Controller should be used for aiming and stabilizing system to provide high dynamic characteristics achieved at the cost of higher complexity and computational cost.

H12: Examination of safety assessment aims, procedures and results from a wider perspective

International Nuclear Information System (INIS)

Neall, F.B; Smith, P.A.

2004-04-01

Safety assessment (SA) are a familiar tool for the evaluation of disposal concepts for radioactive waste. There is, however, often confusion in the wider community about the aims, methods and results used in SA. This report aims to present the H12 SA in a way that makes the assessment process clearer and the implications of the results more meaningful both to workers within the SA field and to a wider technical audience. The reasonableness of the assessment results, the quality of the models and databases and redundancy within the natural and engineered barrier system have been considered. A number of recent and somewhat older SAs that address a range of different waste types, host rocks and disposal concepts have been considered, and comparisons made to H12. A further aim is to put both doses and timescales in a more meaningful context. It has been necessary to: consider ways of demonstrating the meaningfulness of calculations that give results for many thousands of years in the future; provide a framework timescale as a context for SA results over long times; demonstrate the smallness of the risk associated with the doses by comparison with other radiological and non-radiological risks. The perception of risk, which is a critical issue for public acceptance of radioactive waste disposal and must be considered when seeking to present safety assessment results 'in perspective' to a wider audience, is also discussed. It is concluded that H12 is comparable in many ways to assessments carried out internationally. Some assumptions are somewhat arbitrary reflecting the generic stage of the Japanese programme, and are likely to become better founded in future exercises. Nevertheless, H12 provides a clear and well-founded message that it is feasible to site and construct a safe repository from HLW in Japan. (author)

Léopold Senghor e Aimé Césaire letti e interpretati da Giulio Stocchi - Leopold Senghor and Aimé Césaire read and interpreted by Giulio Stocchi

Directory of Open Access Journals (Sweden)

Giulio Stocchi

2011-09-01

Full Text Available This article makes an analysis of fantasy travelling. The poet moves fast between situations and emotions which arise within a continuous and intense familiarity with alterity. Stocchi tells us poetically about two young poets, Aimé Césaire (future sensitive politician and mayor of Fort-de France, capital city of Martinique who goes back to Martinique on a steamer and Léopold Senghor (future president of Senegal and member of the Academie Française who travels back to the fabulous Africa of his childhood on the wings of fantasy. Poetry and more generally art becomes thus the model that men have built for themselves in order to have access to their imagination: The travel of poetry takes place without passport and checkpoints, without borders and States, beyond countries and continents in an universe of changing and heart-rending emotions.

Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses

Science.gov (United States)

Christo, Susan N.; Diener, Kerrilyn R.; Manavis, Jim; Grimbaldeston, Michele A.; Bachhuka, Akash; Vasilev, Krasimir; Hayball, John D.

2016-01-01

Detailing the inflammatory mechanisms of biomaterial-implant induced foreign body responses (FBR) has implications for revealing targetable pathways that may reduce leukocyte activation and fibrotic encapsulation of the implant. We have adapted a model of poly(methylmethacrylate) (PMMA) bead injection to perform an assessment of the mechanistic role of the ASC-dependent inflammasome in this process. We first demonstrate that ASC−/− mice subjected to PMMA bead injections had reduced cell infiltration and altered collagen deposition, suggesting a role for the inflammasome in the FBR. We next investigated the NLRP3 and AIM2 sensors because of their known contributions in recognising damaged and apoptotic cells. We found that NLRP3 was dispensable for the fibrotic encapsulation; however AIM2 expression influenced leukocyte infiltration and controlled collagen deposition, suggesting a previously unexplored link between AIM2 and biomaterial-induced FBR. PMID:26860464

Where are we now? The strengthened safeguards system: Origins, aims, features, issues and prospects

International Nuclear Information System (INIS)

Schriefer, D.

1998-01-01

The present status of the strengthened safeguards system includes the origins, aims, features, issues and future prospects. The areas of emphasis concerning the strengthened safeguards system are: access to information (environmental sampling and improved information analysis), access to sites, rational use of resources (cost analysis of present safeguards, increased cooperation with state systems, cost savings in traditional safeguards activities)

La décadence à la fin du XIXe siècle espagnol: une esthétique de la provocation

Directory of Open Access Journals (Sweden)

Xavier Escudero

2012-03-01

In what way(s do these concepts both make use of and take part in an aesthetic of transgression, or a provocative pose? What does Spanish decadentism really mean, and what are its expressions? In order to answer these questions, we shall first look at the concept of decadentism as applied to the sociocultural phenomenon of Spanish literary bohemianism, which gathers writers and artists defined by constant failure, loose morals and the "cursed" poses they adopt. Then we shall highlight the literary expressions of decadence through the writings of Manuel Machado, Rubén Darío and Ramón María del Valle-Inclán, three prominent authors of the fin-de-siècle letters. Finally we shall take a closer look at the decadent motifs of marginality and lust in the little-known field of modernist bohemian poetry.

Development and application of the RE-AIM QuEST mixed methods framework for program evaluation

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Jane Forman

2017-06-01

The RE-AIM QuEST framework may be a useful tool for improving interventions in real-time, for understanding retrospectively why an intervention did or did not work, and for enhancing its sustainability and translation to other settings.

Using a Mixed-Methods RE-AIM Framework to Evaluate Community Health Programs for Older Latinas.

Science.gov (United States)

Schwingel, Andiara; Gálvez, Patricia; Linares, Deborah; Sebastião, Emerson

2017-06-01

This study used the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework to evaluate a promotora-led community health program designed for Latinas ages 50 and older that sought to improve physical activity, nutrition, and stress management. A mixed-methods evaluation approach was administered at participant and organizational levels with a focus on the efficacy, adoption, implementation, and maintenance components of the RE-AIM theoretical model. The program was shown to be effective at improving participants' eating behaviors, increasing their physical activity levels, and lowering their depressive symptoms. Promotoras felt motivated and sufficiently prepared to deliver the program. Some implementation challenges were reported. More child care opportunities and an increased focus on mental well-being were suggested. The promotora delivery model has promise for program sustainability with both promotoras and participants alike expressing interest in leading future programs.

Locally specific measures for employment aimed at regional development

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Vladimir Cini

2013-12-01

Full Text Available The oldest and largest sub-region in the world functioning on the principle of economic union is the European Union. The creation of a single market has initiated the process of conditional adjustment of markets in the EU member states, which has a significant impact on the social welfare of its citizens. It is necessary to tackle this issue by joint efforts within the European Union. As globalization processes push for economic integration and development of competitive advantage, the regions will have to make some challenging adjustments. The development tends to concentrate in highly competitive regions, while regions in the periphery lag behind. However, this pertains not only to the economic lag, but also to a potential negative political situation. Locally specific active employment policy measures are a continuation of the effort to make these measures more flexible. They refer to the Joint Assessment of Employment Policy Priorities and the IPA Human Resources Development Operational Programme - a regional policy instrument of the European Union. Both documents highlight the issue of disproportional development of regions, which requires special local measures and active labour market policy programmes. To reduce regional differences in development, it is necessary to invest more resources in the regions that lag behind. In this particular case, this means the counties in Croatia with high unemployment rates, a large number of registered unemployed persons and low employment rate. Consequently, this paper explains the importance of the adoption of locally specific measures for employment, which unfortunately did not take hold in the Republic of Croatia, and highlights the need for further decentralization of public services, with the aim of balancing regional development

[From data entry to data presentation at a clinical workstation--experiences with Anesthesia Information Management Systems (AIMS)].

Science.gov (United States)

Benson, M; Junger, A; Quinzio, L; Michel, A; Sciuk, G; Fuchs, C; Marquardt, K; Hempelmannn, G

2000-09-01

Anesthesia Information Management Systems (AIMS) are required to supply large amounts of data for various purposes such as performance recording, quality assurance, training, operating room management and research. It was our objective to establish an AIMS that enables every member of the department to independently access queries at his/her work station and at the same time allows the presentation of data in a suitable manner in order to increase the transfer of different information to the clinical workstation. Apple Macintosh Clients (Apple Computer, Inc. Cupertino, California) and the file- and database servers were installed into the already partially existing hospital network. The most important components installed on each computer are the anesthesia documenting software NarkoData (ProLogic GmbH, Erkrath), HIS client software and a HTML browser. More than 250 queries for easy evaluation were formulated with the software Voyant (Brossco Systems, Espoo, Finland). Together with the documentation they are the evaluation module of the AIMS. Today, more than 20,000 anesthesia procedures are recorded each year at 112 decentralised workstations with the AIMS. In 1998, 90.8% of the 20,383 performed anesthetic procedures were recorded online and 9.2% entered postopeatively into the system. With a corresponding user access it is possible to receive all available patient data at each single anesthesiological workstation via HIS (diagnoses, laboratory results) anytime. The available information includes previous anesthesia records, statistics and all data available from the hospitals intranet. This additional information is of great advantage in comparison to previous working conditions. The implementation of an AIMS allowed to greatly enhance the quota but also the quality of documentation and an increased flow of information at the anesthesia workstation. The circuit between data entry and the presentation and evaluation of data, statistics and results directly

WOMEN, FOOTBALL AND EUROPEAN INTEGRATION. AIMS AND QUESTIONS, METHODOLOGICAL AND THEORETICAL APPROACHES

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Gertrud Pfister

2013-12-01

Full Text Available The aim of this article is to introduce a new research topic and provide information about a European research project focusing on football as a means of European integration. Using the results of available studies of the author and other scholars, it is to be discussed whether and how women can participate in football cultures and contribute to a European identity. Based on theoretical approaches to national identity, gender and socialization, as well as and on the analysis of various intersections between gender, football and fandom, it can be concluded that women are still outsiders in the world of football and that it is doubtful whether female players and fans will contribute decisively to Europeanization processes.

Which Triple Aim related measures are being used to evaluate population management initiatives? An international comparative analysis.

Science.gov (United States)

Hendrikx, Roy J P; Drewes, Hanneke W; Spreeuwenberg, Marieke; Ruwaard, Dirk; Struijs, Jeroen N; Baan, Caroline A

2016-05-01

Population management (PM) initiatives are introduced in order to create sustainable health care systems. These initiatives should focus on the continuum of health and well-being of a population by introducing interventions that integrate various services. To be successful they should pursue the Triple Aim, i.e. simultaneously improve population health and quality of care while reducing costs per capita. This study explores how PM initiatives measure the Triple Aim in practice. An exploratory search was combined with expert consultations to identify relevant PM initiatives. These were analyzed based on general characteristics, utilized measures and related selection criteria. In total 865 measures were used by 20 PM initiatives. All quality of care domains were included by at least 11 PM initiatives, while most domains of population health and costs were included by less than 7 PM initiatives. Although their goals showed substantial overlap, the measures applied showed few similarities between PM initiatives and were predominantly selected based on local priority areas and data availability. Most PM initiatives do not measure the full scope of the Triple Aim. Additionally, variety between measures limits comparability between PM initiatives. Consensus on the coverage of Triple Aim domains and a set of standardized measures could further both the inclusion of the various domains as well as the comparability between PM initiatives. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A 3-Month Jump-Landing Training Program: A Feasibility Study Using the RE-AIM Framework

NARCIS (Netherlands)

Aerts, I.; Cumps, E.; Verhagen, E.A.L.M.; Mathieu, N.; Van Schuerbeeck, S.; Meeusen, R.

2013-01-01

Context: Evaluating the translatability and feasibility of an intervention program has become as important as determining the effectiveness of the intervention. Objective: To evaluate the applicability of a 3-month jumplanding training program in basketball players, using the RE-AIM (reach,

Effects of an inconsistency-detection training aimed at improving comprehension monitoring in primary school children

NARCIS (Netherlands)

Wassenburg, S.I.; Bos, L.T.; de Koning, B.B.; van der Schoot, M.

2015-01-01

Grounded within the situation model framework, this study investigated the effectiveness of a reading comprehension strategy training aimed at improving children’s comprehension monitoring strategies. Sixty-four third and fourth graders received a 4-week training targeted at situation model

A Lustful Passion for Clarification: Bildung, Aufklärung, and the Sight of Sexual Imagery

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Stephanie D'Alessandro

1998-01-01

Full Text Available The equation of education and self-cultivation was an Enlightenment ideal which has become a hallmark of bourgeois culture. Prizing Bildung , the bourgeoisie professed an appreciation for art, music, and literature. Within their libraries, comprehensive scholarly texts intended for academic and well-educated, lay audiences occupied a special place. Marrying illustration with academic investigation, the Sittengeschichte (history of morals could also be found on the bourgeois library shelf and afforded its readers a glimpse into a world outside the strict parameters of bourgeois propriety. During the Weimar Republic, the demand for illustrated Sittengeschichten increased dramatically among the bourgeoisie, meeting their ideal of Bildung and intersecting with the more general eroticization of visual imagery at the time. Images were transformed into legitimate source material through the manner in which they were accessed and controlled by readers; potentially obscene material was domesticated in books by associations of class and culture. However, while they served an instructional need, the books also met an erotic market demand. In considering them, the social needs, sexual anxieties, and bodily desires of reading audiences commingle on these pages, revealing useful insights into the bourgeois institutions of culture and moral order in 1920s Germany.

Disgust versus Lust: Exploring the Interactions of Disgust and Fear with Sexual Arousal in Women.

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Diana S Fleischman

Full Text Available Sexual arousal is a motivational state that moves humans toward situations that inherently pose a risk of disease transmission. Disgust is an emotion that adaptively moves humans away from such situations. Incongruent is the fact that sexual activity is elementary to human fitness yet involves strong disgust elicitors. Using an experimental paradigm, we investigated how these two states interact. Women (final N=76 were assigned to one of four conditions: rate disgust stimuli then watch a pornographic clip; watch a pornographic clip then rate disgust stimuli; rate fear stimuli then watch a pornographic clip; or watch a pornographic clip then rate fear stimuli. Women's genital sexual arousal was measured with vaginal photoplethysmography and their disgust and fear reactions were measured via self-report. We did not find that baseline disgust propensity predicted sexual arousal in women who were exposed to neutral stimuli before erotic content. In the Erotic-before-Disgust condition we did not find that sexual arousal straightforwardly predicted decreased image disgust ratings. However, we did find some evidence that sexual arousal increased self-reported disgust in women with high trait disgust and sexual arousal decreased self-reported disgust in women with low trait disgust. Women who were exposed to disgusting images before erotic content showed significantly less sexual arousal than women in the control condition or women exposed to fear-inducing images before erotic content. In the Disgust-before-Erotic condition the degree of self-reported disgust was negatively correlated with genital sexual arousal. Hence, in the conflict between the ultimate goals of reproduction and disease avoidance, cues of the presence of pathogens significantly reduce the motivation to engage in mating behaviors that, by their nature, entail a risk of pathogen transmission.

Arafati nõunik : "Yasser on kuningas, kes elab vangis" / Walid Abu Zalaf ; interv. Katrin Lust

Index Scriptorium Estoniae

Abu Zalaf, Walid

2004-01-01

Yasser Arafati meedianõunik, Palestiina ja Araabia suurima lehe al-Quds tegevjuht vastab küsimustele oma töö, juutide-palestiinlaste vahelise viha, Arafati ning tema perekonna asupaiga kohta. Lisa: Nõunikud: Arafati elu pole ohus

Disgust versus Lust: Exploring the Interactions of Disgust and Fear with Sexual Arousal in Women

Science.gov (United States)

Fleischman, Diana S.; Hamilton, Lisa Dawn; Fessler, Daniel M. T.; Meston, Cindy M.

2015-01-01

Sexual arousal is a motivational state that moves humans toward situations that inherently pose a risk of disease transmission. Disgust is an emotion that adaptively moves humans away from such situations. Incongruent is the fact that sexual activity is elementary to human fitness yet involves strong disgust elicitors. Using an experimental paradigm, we investigated how these two states interact. Women (final N=76) were assigned to one of four conditions: rate disgust stimuli then watch a pornographic clip; watch a pornographic clip then rate disgust stimuli; rate fear stimuli then watch a pornographic clip; or watch a pornographic clip then rate fear stimuli. Women’s genital sexual arousal was measured with vaginal photoplethysmography and their disgust and fear reactions were measured via self-report. We did not find that baseline disgust propensity predicted sexual arousal in women who were exposed to neutral stimuli before erotic content. In the Erotic-before-Disgust condition we did not find that sexual arousal straightforwardly predicted decreased image disgust ratings. However, we did find some evidence that sexual arousal increased self-reported disgust in women with high trait disgust and sexual arousal decreased self-reported disgust in women with low trait disgust. Women who were exposed to disgusting images before erotic content showed significantly less sexual arousal than women in the control condition or women exposed to fear-inducing images before erotic content. In the Disgust-before-Erotic condition the degree of self-reported disgust was negatively correlated with genital sexual arousal. Hence, in the conflict between the ultimate goals of reproduction and disease avoidance, cues of the presence of pathogens significantly reduce the motivation to engage in mating behaviors that, by their nature, entail a risk of pathogen transmission. PMID:26106894

Disgust versus Lust: Exploring the Interactions of Disgust and Fear with Sexual Arousal in Women.

Science.gov (United States)

Fleischman, Diana S; Hamilton, Lisa Dawn; Fessler, Daniel M T; Meston, Cindy M

2015-01-01

Sexual arousal is a motivational state that moves humans toward situations that inherently pose a risk of disease transmission. Disgust is an emotion that adaptively moves humans away from such situations. Incongruent is the fact that sexual activity is elementary to human fitness yet involves strong disgust elicitors. Using an experimental paradigm, we investigated how these two states interact. Women (final N=76) were assigned to one of four conditions: rate disgust stimuli then watch a pornographic clip; watch a pornographic clip then rate disgust stimuli; rate fear stimuli then watch a pornographic clip; or watch a pornographic clip then rate fear stimuli. Women's genital sexual arousal was measured with vaginal photoplethysmography and their disgust and fear reactions were measured via self-report. We did not find that baseline disgust propensity predicted sexual arousal in women who were exposed to neutral stimuli before erotic content. In the Erotic-before-Disgust condition we did not find that sexual arousal straightforwardly predicted decreased image disgust ratings. However, we did find some evidence that sexual arousal increased self-reported disgust in women with high trait disgust and sexual arousal decreased self-reported disgust in women with low trait disgust. Women who were exposed to disgusting images before erotic content showed significantly less sexual arousal than women in the control condition or women exposed to fear-inducing images before erotic content. In the Disgust-before-Erotic condition the degree of self-reported disgust was negatively correlated with genital sexual arousal. Hence, in the conflict between the ultimate goals of reproduction and disease avoidance, cues of the presence of pathogens significantly reduce the motivation to engage in mating behaviors that, by their nature, entail a risk of pathogen transmission.

"Back-fire to lust": G. Stanley Hall, sex-segregated schooling, and the engine of sublimation.

Science.gov (United States)

Graebner, William

2006-08-01

G. Stanley Hall was an advocate of sex-segregated schooling long after most Americans had accepted coeducation. His position was based in part on personal experience: observations of his father and mother, a repressed and guilt-ridden boyhood sexuality, and his conviction that his own career success was a product of sublimated sexual desire, of erotic energy converted into mental energy. Hall theorized that coeducation put sublimation at risk, and that sex-segregated schools, by contributing to proper gendered development and by prolonging and sublimating the sexual tensions of adolescence, would produce social progress.

Indian Country Leaking Underground Storage Tank (LUST) Points, Region 9, 2016, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — This GIS dataset contains point features that represent Leaking Underground Storage Tanks in US EPA Region 9 Indian Country. This dataset contains facility name and...

Real-World Dosing Patterns of Atomoxetine in Adults with Attention-Deficit/Hyperactivity Disorder.

Science.gov (United States)

Kabul, Samaneh; Alatorre, Carlos; Montejano, Leslie B; Farr, Amanda M; Clemow, David B

2015-12-01

The aim was to investigate the dosing patterns of atomoxetine monotherapy in adult patients with attention-deficit/hyperactivity disorder (ADHD) in a retrospective analysis. Adult (≥ 18 years) patients with ADHD newly initiated on atomoxetine with ≥ 1 outpatient pharmacy claim for atomoxetine between January 2006 and December 2011 were selected from the Truven Health MarketScan(®) Commercial database. After a 30-day titration period, dosing patterns of atomoxetine monotherapy were analyzed in the 12 months following initiation. In addition, patient demographic and clinical characteristics were compared to identify characteristics associated with suboptimal versus recommended dosing. Of the 12,412 adult patients with ADHD newly initiated on atomoxetine, 4548 (36.6%) were suboptimally dosed, whereas 3323 (26.7%) were treated at recommended dose. Overall, study patients were treated at a mean (standard deviation [SD]) dose of 68.5 (44.9) mg/day. The suboptimal dosing cohort included significantly more females (54% vs. 44%, P atomoxetine therapy in a real-world setting are often dosed suboptimally. Increasing the awareness on optimal dosing strategy among clinicians and patients is warranted to maximize the therapeutic benefits of atomoxetine among adult patients with ADHD. © 2015 Eli Lilly and Company. CNS Neuroscience and Therapeutics published by John Wiley & Sons Ltd.

Aiming for cure in HBV and HDV infection.

Science.gov (United States)

Petersen, Jörg; Thompson, Alexander J; Levrero, Massimo

2016-10-01

Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide. Currently available antiviral treatment options for chronic hepatitis B include pegylated interferon alpha2a (PegIFN) or nucleos(t)ide analogues (NAs). The major advantages of NAs are good tolerance and potent antiviral activity associated with high rates of sustained on-treatment response to therapy. The advantages of PegIFN include a finite course of treatment, the absence of drug resistance, and an opportunity to obtain a durable post-treatment response to therapy. Furthermore, PegIFN is the only approved agent known to be active against hepatitis D virus (HDV). The use of these two antiviral agents with different mechanisms of action in combination against hepatitis B is theoretically an attractive approach for treatment. Although several studies have confirmed certain virological advantages of combination therapies, data supporting a long-term clinical benefit for patients are lacking and monotherapy with PegIFN or NAs remains the therapy of choice. Moreover, with the current treatment approaches, only a limited number of patients achieve hepatitis B surface antigen (HBsAg) loss. HBsAg loss is considered a "functional cure", but does not mean viral eradication. There is a need for novel therapeutic approaches that enable not only suppression of viral replication, but resolution of HBV infection. A key challenge is to target covalently closed circular DNA (cccDNA) in the nucleus of infected hepatocytes. The recent development and availability of innovative in vitro and in vivo systems and sensitive molecular techniques has opened new possibilities to study the complex network of interactions that HBV establishes with the host in the course of infection and to define new targets for antiviral strategies. Several new antiviral or immunomodulatory compounds have reached preclinical or clinical testing with the aim of silencing or eradicating cccDNA to achieve functional cure

Development Principles of the Pedagogical System Aimed at Bachelor Training Based on Modern Information Technology

Science.gov (United States)

Kurymbayev, Sayat G.; Samashova, Gulfarida E.; Alshynbayeva, Zhuldyz E.; Mukhametzhanova, Aigul O.; Sharazdin, Adilzada M.; Kalybekova, Kalamkas S.; Kosybaeva, Umitzhan A.

2016-01-01

Modern education is aimed at training competent specialists, which requires modernizing the training process by implementing innovative technologies, especially information technologies. Information technologies allow quickly accessing necessary data, which speeds up the training process. This paper deals with issues related to training bachelors…

A review on the availability of ecological data aiming new researches in Peri Lagoon

Directory of Open Access Journals (Sweden)

Maurício Mello Petrucio

2008-06-01

Full Text Available The increase in population as well as the water resource demand has been intensifying the human influence in Peri Lagoon basin. A review on the availability of data concerning the ecology of Peri Lagoon was made, aiming at the development of new researches to understand the functioning of this ecosystem. This information can contribute to the elaboration of a conservation proposal and sustainable use of the Lagoon in the future. High cyanobacteria density (Cylindrospermopsis raciborskii was detected in the Lagoon waters, which happens to be a risky situation for the ecosystem’s health and consequently for the population. The review highlights a lack of available information about the dynamics, functioning and structure of aquatic communities, as well as their relationships with the surrounding area and the infl uence of abiotic factors. Series of continuum data with respect to time are also considered to be lacking. Educational, political and social practices in environmental conservation are necessary, aiming at the management and sustainable use of Peri Lagoon basin. These practices will guarantee water resource quality and availability for the current and future generations.

An Employee-Centered Care Model Responds to the Triple Aim: Improving Employee Health.

Science.gov (United States)

Fox, Kelly; McCorkle, Ruth

2018-01-01

Health care expenditures, patient satisfaction, and timely access to care will remain problematic if dramatic changes in health care delivery models are not developed and implemented. To combat this challenge, a Triple Aim approach is essential; Innovation in payment and health care delivery models is required. Using the Donabedian framework of structure, process, and outcome, this article describes a nurse-led employee-centered care model designed to improve consumers' health care experiences, improve employee health, and increase access to care while reducing health care costs for employees, age 18 and older, in a corporate environment.

[A workplace intervention aimed at increasing awareness in nursing personnel performing manual handling activities].

Science.gov (United States)

Scorpiniti, A; Lorusso, A; L'Abbate, N

2007-01-01

Here we describe a workplace intervention aimed at reducing the risk of low back pain in nursing personnel. The intervention we carried out included a specific ergonomic training and an exercise program according to the Feldenkrais Method. After the intervention, we evaluated its effect on the execution of manual handling activities in nurses. We found an increased rate of correct manual handling in the post-intervention period.

An Evaluation Model for a Multidisciplinary Chronic Pelvic Pain Clinic: Application of the RE-AIM Framework.

Science.gov (United States)

Chen, Innie; Money, Deborah; Yong, Paul; Williams, Christina; Allaire, Catherine

2015-09-01

Chronic pelvic pain (CPP) is a prevalent, debilitating, and costly condition. Although national guidelines and empiric evidence support the use of a multidisciplinary model of care for such patients, such clinics are uncommon in Canada. The BC Women's Centre for Pelvic Pain and Endometriosis was created to respond to this need, and there is interest in this model of care's impact on the burden of disease in British Columbia. We sought to create an approach to its evaluation using the RE-AIM (Reach, Efficacy, Adoption, Implementation, Maintenance) evaluation framework to assess the impact of the care model and to guide clinical decision-making and policy. The RE-AIM evaluation framework was applied to consider the different dimensions of impact of the BC Centre. The proposed measures, data sources, and data management strategies for this mixed-methods approach were identified. The five dimensions of impact were considered at individual and organizational levels, and corresponding indicators were proposed to enable integration into existing data infrastructure to facilitate collection and early program evaluation. The RE-AIM framework can be applied to the evaluation of a multidisciplinary chronic pelvic pain clinic. This will allow better assessment of the impact of innovative models of care for women with chronic pelvic pain.

An intervention programme using the ASE-model aimed at enhancing adherence in adolescents with asthma

NARCIS (Netherlands)

van Es, S M; Nagelkerke, A F; Colland, V T; Scholten, R J; Bouter, L M

A randomised controlled trial, involving 112 adolescents with asthma, and a 2-year follow-up was conducted to assess the impact of an intervention programme aimed at enhancing adherence to asthma medication. This programme had a duration of 1 year and consisted of an experimental group which

An intervention programme using the ASE-model aimed at enhancing adherence in adolescents with asthma

NARCIS (Netherlands)

van Es, S.M.; Nagelkerke, A.F.; Colland, V.T.; Scholten, R.J.P.M.; Bouter, L.M.

2001-01-01

A randomised controlled trial, involving 112 adolescents with asthma, and a 2-year follow-up was conducted to assess the impact of an intervention programme aimed at enhancing adherence to asthma medication. This programme had a duration of 1 year and consisted of an experimental group which

Characterizing the Learning Effect in Response to Biofeedback Aimed at Reducing Tibial Acceleration during Running

Directory of Open Access Journals (Sweden)

Linda M. A. van Gelder

2018-02-01

Full Text Available Increased tibial acceleration has been found to be an important risk factor for tibial stress fractures. Interventions aimed at reducing this variable which found a beneficial effect include the use of biofeedback in gait retraining. However, no studies have focused on the time participants take to modify tibial acceleration, therefore we aimed to find the start of a learning plateau in this study. Six participants ran on a treadmill while multisensory feedback was given. A single-subject analysis was used to characterise the learning effects. All participants changed peak tibial acceleration within the first step of running in the feedback condition. Two participants further reduced tibial acceleration to reach a plateau within 120 steps. In four of the six participants a strong effect of the feedback was still present after a week. Further research is needed to optimise the use of biofeedback in reducing the prevalence of tibial stress fractures.

Physical activity interventions to promote positive youth development among indigenous youth: a RE-AIM review.

Science.gov (United States)

Baillie, Colin P T; Galaviz, Karla I; Emiry, Kevin; Bruner, Mark W; Bruner, Brenda G; Lévesque, Lucie

2017-03-01

Physical activity (PA) programs are a promising strategy to promote positive youth development (PYD). It is not known if published reports provide sufficient information to promote the implementation of effective PYD in indigenous youth. The purpose of this study was to assess the extent to which published literature on PA programs that promote PYD in indigenous youth report on RE-AIM (reach, effectiveness, adoption, implementation, maintenance) indicators. A systematic literature search was conducted to identify articles reporting on PA programs that promote PYD in indigenous youth. The search yielded 8084 articles. A validated 21-item RE-AIM abstraction tool assessing internal and external validity factors was used to extract data from 10 articles meeting eligibility criteria. The most commonly reported dimensions were effectiveness (73 %), adoption (48 %), and maintenance (43 %). Reach (34 %) and implementation (30 %) were less often reported. Published research provides insufficient information to inform real-world implementation of PA programs to promote PYD in indigenous youth.