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Sample records for affecting cct development

  1. Environmental issues affecting CCT development

    Energy Technology Data Exchange (ETDEWEB)

    Reidy, M. [U.S. House of Representatives, Washington, DC (United States)

    1997-12-31

    While no final legislative schedule has been set for the new Congress, two issues with strong environmental ramifications which are likely to affect the coal industry seem to top the list of closely watched debates in Washington -- the Environmental Protection Agency`s proposed new ozone and particulate matter standards and utility restructuring. The paper discusses the background of the proposed standards, public comment, the Congressional review of regulations, other legislative options, and utility restructuring.

  2. Summary of panel session 3 -- Environmental issues affecting CCT deployment

    Energy Technology Data Exchange (ETDEWEB)

    Hausker, K. [Center for Strategic and International Studies, Washington, DC (United States)

    1997-12-31

    The panelists discussed a variety of environmental issues that affect CCT deployment, and more broadly speaking, power development in general. The issues were both international and domestic in nature. The author summarizes the issues discussed. A summary is also presented which highlights ideas from the panelists that could be characterized as solutions to the demand for improved environmental performance and the surrounding uncertainties. The author offers some personal comments and observations.

  3. Environmental issues affecting CCT development

    Energy Technology Data Exchange (ETDEWEB)

    Wainman, B. [U.S. House of Representatives, Washington, DC (United States)

    1997-12-31

    The author discusses her thoughts on prospects for an energy policy from this Congress. She doesn`t believe the country will see any big sweeping energy policy acts or even utility deregulation in the next two years. Education on the issues is necessary. The author discusses the impacts for clean coal technologies and recommends continued aggressive work on deployment.

  4. Hemodynamic and affective correlates assessed during performance on the Columbia card task (CCT).

    Science.gov (United States)

    Holper, Lisa; Murphy, Ryan O

    2014-12-01

    The study aimed to test the potential of functional near-infrared spectroscopy (fNIRS) in combination with electrodermal activity (EDA) in a decision paradigm by means of the Columbia card task (CCT). The CCT is a dynamic decision task characterized by assessing subjects' risk-taking via eliciting voluntary stopping points in a series of incrementally increasingly risky choices. Using the combined fNIRS-EDA approach, we aim to examine the hemodynamic and affective correlates of both decision and outcome responses during performance on the CCT. Twenty healthy subjects completed the Cold and Hot CCT version while fNIRS over prefrontal cortex and EDA were recorded. Results showed that (1) in the decision phase fNIRS revealed larger total hemoglobin concentration changes [tHb] in the Cold as compared to the Hot CCT, whereas EDA revealed an opposite pattern with larger skin conductance responses (SCRs) to the Hot as compared to the Cold CCT. (2) No significant [tHb] signals or SCRs were found in the outcome phase. (3) Coherence calculations between fNIRS and EDA in the heart rate frequency showed a significant increase during the Hot as compared to the Cold CCT. Our findings designate fNIRS as suitable tool for monitoring decision-making processes. The combination of fNIRS and EDA demonstrates the potential of simultaneously assessing the interaction between hemodynamic and affective responses which can provide additional information concerning the relationship between these two physiological systems for various research areas. PMID:24242358

  5. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.

    Science.gov (United States)

    Yap, Timothy A; Walton, Mike I; Hunter, Lisa-Jane K; Valenti, Melanie; de Haven Brandon, Alexis; Eve, Paul D; Ruddle, Ruth; Heaton, Simon P; Henley, Alan; Pickard, Lisa; Vijayaraghavan, Gowri; Caldwell, John J; Thompson, Neil T; Aherne, Wynne; Raynaud, Florence I; Eccles, Suzanne A; Workman, Paul; Collins, Ian; Garrett, Michelle D

    2011-02-01

    AKT is frequently deregulated in cancer, making it an attractive anticancer drug target. CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. CCT128930 caused a G(1) arrest in PTEN-null U87MG human glioblastoma cells, consistent with AKT pathway blockade. Pharmacokinetic studies established that potentially active concentrations of CCT128930 could be achieved in human tumor xenografts. Furthermore, CCT128930 also blocked the phosphorylation of several downstream AKT biomarkers in U87MG tumor xenografts, indicating AKT inhibition in vivo. Antitumor activity was observed with CCT128930 in U87MG and HER2-positive, PIK3CA-mutant BT474 human breast cancer xenografts, consistent with its pharmacokinetic and pharmacodynamic properties. A quantitative immunofluorescence assay to measure the phosphorylation and total protein expression of the AKT substrate PRAS40 in hair follicles is presented. Significant decreases in pThr246 PRAS40 occurred in CCT128930-treated mouse whisker follicles in vivo and human hair follicles treated ex vivo, with minimal changes in total PRAS40. In conclusion, CCT128930 is a novel, selective, and potent AKT inhibitor that blocks AKT activity in vitro and in vivo and induces marked antitumor responses. We have also developed a novel biomarker assay for the inhibition of AKT in human hair follicles, which is currently being used in clinical trials. PMID:21191045

  6. Influence of plastic deformation on CCT-diagrams of new-developed microalloyed steel

    OpenAIRE

    M. Opiela; W. Zalecki; A. Grajcar

    2012-01-01

    Purpose: The aim of the paper is to investigate the influence of plastic deformation and cooling conditions on a structure and a shape of CCT-diagrams of new-developed Nb-Ti-V microalloyed steel.Design/methodology/approach: The diagrams of undeformed and plastically-deformed supercooled austenite transformations for Nb-Ti-V microalloyed steel were determined. A part of the specimens were austenitized at a temperature of 885°C and next cooled to ambient temperature with a various rate from 234...

  7. CCT deployment considerations

    International Nuclear Information System (INIS)

    The deployment of Clean Coal Technologies (CCT) is discussed by asserting that in the case of commercializing CCT, the government's involvement should not stop at the demonstration gate. Two areas in this regard are described. First, the need for the domestic DOE CCT Program to focus on the domestic deployment of demonstrated technologies, and second, the need to recognize that to participate in the phenomenal growth of international power markets through use of clean coal or advanced coal technologies an aggressive partnering between the government and industry to demonstrate technologies abroad will be required. The Clean Coal Technology Coalition's (CCT) primary mission has been to promote the development and use of CCTs. The CCT is a strong advocate for the DOE CCT Program and applauds the Department's and industry's success at developing many coal-based technologies. By current design, the DOE program is said to go no further than the initial demonstration of a technology. Since the inception of CCT in 1986, the Coalition has advocated the need to pursue a partnership with government in which more than one demonstration of the same or similar technology is supported by the clean coal program. Only in this way can one be assured of widespread acceptance of any given technology. There exists a gap (call it a open-quotes risk gapclose quotes) between CCTs that have been successfully demonstrated (and presumably available for commercial use) and their widespread commercial use. A technology matrix has been developed in which the developmental status of a variety of clean coal technologies is demonstrated. While still too early to pass judgment, it appears that while success is being achieved in demonstrating advanced coal technologies, the market place - for several reasons - is not, indeed may have no plans, to adopt these technologies

  8. Influence of plastic deformation on CCT-diagrams of new-developed microalloyed steel

    Directory of Open Access Journals (Sweden)

    M. Opiela

    2012-04-01

    Full Text Available Purpose: The aim of the paper is to investigate the influence of plastic deformation and cooling conditions on a structure and a shape of CCT-diagrams of new-developed Nb-Ti-V microalloyed steel.Design/methodology/approach: The diagrams of undeformed and plastically-deformed supercooled austenite transformations for Nb-Ti-V microalloyed steel were determined. A part of the specimens were austenitized at a temperature of 885°C and next cooled to ambient temperature with a various rate from 234°C/s to 1°C/min. To investigate the influence of plastic deformation on a shape of CCT (Continuous Cooling Transformations diagrams, another part of the specimens were 50% deformed at 885°C or 1100°C and cooled to ambient temperature with a rate from 95°C/s to 1°C/min. The DIL 805A/D dilatometer, with a LVDT-type measuring head, was used to carry out dilatometric test.Findings: Performed dilatometric research revealed that the steel is characterized with Ac3=843°C, Ac1=707°C and a relatively low Ms temperature equal 370°C. Plastic deformation of steel at the temperature of 885°C prior to the start of phase transformations results in distinct acceleration of pearlitic transformation and slight translation of bainitic transformation towards shorter times.Research limitations/implications: Elaborated curves of supercooled austenite transformations of studied steel fully predispose it to production of forgings quenched directly from forging finish temperature and successively subjected to high temperature tempering.Practical implications: The obtained CCT diagrams of supercooled plastically-deformed austenite transformations can be useful in determination of cooling condition of the thermo-mechanical processing for high strength forged machine parts obtained from microalloyed steels.Originality/value: The diagrams of the plastically-deformed supercooled austenite for a new-developed microalloyed steel were obtained.

  9. Energy Saving Melting and Revert Reduction Technology (Energy SMARRT): Development of CCT Diagrams

    Energy Technology Data Exchange (ETDEWEB)

    Chumbley, L Scott

    2011-08-20

    goal of this study was to accurately characterize the solid-solid phase transformations seen in cast superaustenitic stainless steels. Heat treatments were performed to understand the time and temperature ranges for intermetallic phase formations in alloys CN3MN and CK3McuN. Microstructures were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy and wavelength dispersive spectroscopy (EDS, WDS). In this way TTT and CCT diagrams could be developed for the matrix of samples chosen. As this study consisted of basic research into the development of TTT and CCT diagrams as an aid to the US steel casting industry, there is no formal commercialization plan associated with this task other than presentations and publications via the Steel Founders Society of America to their members. The author is confident that the data contained in this report can be used by steel foundries to refine their casting procedures in such a way as to reduce the amount of waste produced and energy wasted by significantly reducing or eliminating the need for remelting or recasting of material due to unwanted, premature intermetallic formation. This development of high alloy steel CCT diagrams was predicted to result in an average energy savings of 0.05 trillion BTU's/year over a 10 year period (with full funding). With 65% of the proposed funding, current (2011) annual energy saving estimates, based on initial dissemination to the casting industry in 2011and market penetration of 97% by 2020, is 0.14 trillion BTU's/year. The reduction of scrap and improvement in casting yield will also result in a reduction of environmental emissions associated with the melting and pouring of the steel. The average annual estimate of CO2 reduction per year through 2020 is 0.003 Million Metric Tons of Carbon Equivalent (MM TCE)

  10. Digital Badges for Teacher Mastery: An Exploratory Study of a Competency-Based Professional Development Badge System. CCT Reports

    Science.gov (United States)

    Diamond, James; Gonzalez, Pilar Carmina

    2014-01-01

    This study contributes knowledge about how a digital badge system integrated into an online, subject-matter-specific, and competency-based professional development (PD) program affected teachers' experiences with and perceptions of the program activities. The report presents findings from a one-year exploratory study of an online PD program, and…

  11. Comparative proteomic analysis of the shoot apical meristem in maize between a ZmCCT-associated near-isogenic line and its recurrent parent.

    Science.gov (United States)

    Wu, Liuji; Wang, Xintao; Wang, Shunxi; Wu, Liancheng; Tian, Lei; Tian, Zhiqiang; Liu, Ping; Chen, Yanhui

    2016-01-01

    The ZmCCT, one of the most important genes affecting photoperiod response, delays flowering under long-day conditions in maize (Zea mays). In this study we used the isobaric tags for relative and absolute quantification (iTRAQ) technique-based proteomics approach to identify differentially expressed proteins between a near-isogenic line (NIL) and its recurrent parent, contrasting in alleles of ZmCCT. A total of 5,259 distinct proteins were identified. Among them, 386 proteins were differentially expressed between NIL-cml line (ZmCCT-positive) and H4 line (ZmCCT-negative). Functional categorization showed that the differentially proteins were mainly involved in energy production, photosynthesis, signal transduction, and cell organization and biogenesis. Our results showed that during shoot apical meristem (SAM) development cell division proteins, carbohydrate metabolism-related proteins, and flower inhibition-related proteins were more abundant in the ZmCCT-positive line than the ZmCCT-negative line. These results, taken together with morphological observations, showed that the effect of ZmCCT on flowering might be caused by its effect on one or all of these biological processes. Although the exact roles of these putative related proteins remain to be examined, our results obtained using the proteomics approach lead to a better understanding of the photoperiodicity mechanism in maize plants. PMID:27468931

  12. Completing the CCT mission: The challenge of change

    Energy Technology Data Exchange (ETDEWEB)

    Monk, J.R. [Illinois Energy Association, Springfield, IL (United States)

    1997-12-31

    In order to complete the clean coal technology mission it will be necessary to determine CCT`s role in the restructured electricity industry and develop a strategy to promote that role. First, one must understand where the industry is headed and how clean coal technology fits into that future. Then, one needs to develop a strategy for getting from here to there, from where CCT is today to where it must be in five, ten or twenty years to be a viable option for decision-makers. Coal makes sense for the United States for several important reasons, not the least of which is its abundance here. It also makes sense in terms of its economic impact on large areas of the nation. And if coal makes sense, especially economically, then clean coal technology makes even more sense because of its potential to capitalize on this abundant resource in an environmentally friendly manner. But after nearly thirty years of involvement in the political world at all levels from Washington, D.C. to Washington, Indiana, the author has learned the hard way that ``common sense`` does not always, or even often, carry the day in the policymaking process. He believes that the future of clean coal technology hinges on the ability in the next few months and years to mobilize all those who favor that technology to move forward in a cohesive and coordinated effort to affect the policymaking and political process and thereby promote and accelerate CCT development. If this can be done, then the nation will be well on the way to completing the clean coal technology mission and meeting the challenge of change.

  13. Cytoplasm Affects Embryonic Development

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Recent studies by CAS researchers furnish strong evidence that a fertilized egg's nucleus isn't the sole site of control for an embryo's development. A research team headed by Prof. Zhu Zuoyan from the CAS Institute of Hydrobiology in Wuhan discovered that cytoplasm affects the number of vertebrae in cloned offspring created when nuclei from one fish genus were transplanted to enucleated eggs of another.

  14. Increased CCT-eta expression is a marker of latent and active disease and a modulator of fibroblast contractility in Dupuytren's contracture.

    Science.gov (United States)

    Satish, Latha; O'Gorman, David B; Johnson, Sandra; Raykha, Christina; Gan, Bing Siang; Wang, James H-C; Kathju, Sandeep

    2013-07-01

    Dupuytren's contracture (DC) is a fibroproliferative disorder of unknown etiology characterized by a scar-like contracture that develops in the palm and/or digits. We have previously reported that the eta subunit of the chaperonin containing T-complex polypeptide (CCT-eta) is increased in fibrotic wound healing, and is essential for the accumulation of α-smooth muscle actin (α-SMA) in fibroblasts. The purpose of this study was to determine if CCT-eta is similarly implicated in the aberrant fibrosis seen in DC and to investigate the role of CCT-eta in the behavior of myo/fibroblasts in DC. Fibroblasts were obtained from DC-affected palmar fascia, from adjacent phenotypically normal palmar fascia in the same DC patients (PF), and from non-DC palmar fascial tissues in patients undergoing carpal tunnel (CT) release. Inherent contractility in these three populations was examined using fibroblast-populated collagen lattices (FPCLs) and by cell traction force microscopy. Expression of CCT-eta and α-SMA protein was determined by Western blot. The effect of CCT-eta inhibition on the contractility of DC cells was determined by deploying an siRNA versus CCT-eta. DC cells were significantly more contractile than both matching palmar fascial (PF) cells and CT cells in both assays, with PF cells demonstrating an intermediate contractility in the FPCL assay. Whereas α-SMA protein was significantly increased only in DC cells compared to PF and CT cells, CCT-eta protein was significantly increased in both PF and DC cells compared to CT cells. siRNA-mediated depletion of CCT-eta inhibited the accumulation of both CCT-eta and α-SMA protein in DC cells, and also significantly decreased the contractility of treated DC cells. These observations suggest that increased expression of CCT-eta appears to be a marker for latent and active disease in these patients and to be essential for the increased contractility exhibited by these fibroblasts. PMID:23292503

  15. The role of the Chaperonin containing t-complex polypeptide 1, subunit 8 (CCT8) in B-cell non-Hodgkin's lymphoma.

    Science.gov (United States)

    Yin, Haibing; Miao, Xiaobing; Wu, Yaxun; Wei, Yingze; Zong, Guijuan; Yang, Shuyun; Chen, Xudong; Zheng, Guihua; Zhu, Xinghua; Guo, Yan; Li, Chunsun; Chen, Yali; Wang, Yuchan; He, Song

    2016-06-01

    The chaperonin containing t-complex polypeptide 1 (CCT) is known to mediate folding of proteins. CCT, subunit 8 (CCT8), is the θ subunit of CCT complex chaperonin. CCT8 has been reported to be dysregulated in several tumor tissues. In this study, we investigated the role of CCT8 in B-cell non-Hodgkin's lymphoma (NHL). Clinically, the expression levels of CCT8 in reactive lymphoid hyperplasia (RLH) and B-cell NHL specimens were investigated using immunohistochemical analysis. We found that CCT8 was highly expressed in proliferating germinal center cells compared with the quiescent cells of the follicular mantle zone. Furthermore, CCT8 was highly expressed in progressive lymphomas than in indolent lymphomas. Kaplan-Meier curve showed that high expression of CCT8 was significantly associated with shorter overall survival in patients with diffuse large B-cell lymphoma. Moreover, we demonstrated that CCT8 could promote the proliferation of B-cell NHL cells. In addition, we found that CCT8 could accelerate the G1/S transition in B-cell NHL. Finally, we demonstrated that overexpression of CCT8 could reverse cell adhesion-mediated drug resistance (CAM-DR) phenotype. Our study may shed new insights into the important role of CCT8 in cancer development. PMID:27101149

  16. CONSOL`s perspective on CCT deployment

    Energy Technology Data Exchange (ETDEWEB)

    Burke, F.P.; Statnick, R.M. [CONSOL Inc., Library, PA (United States)

    1997-12-31

    The principal focus of government investment in Clean Coal Technology must be to serve the interests of the US energy consumer. Because of its security of supply and low cost, coal will continue to be the fuel of choice in the existing domestic electricity generating market. The ability of coal to compete for new generating capacity will depend largely on natural gas prices and the efficiency of coal and gas-fired generating options. Furthermore, potential environmental regulations, coupled with utility deregulation, create a climate of economic uncertainty that may limit future investment decisions favorable to coal. Therefore, the federal government, through programs such as CCT, should promote the development of greenfield and retrofit coal use technology that improves generating efficiency and meets environmental requirements for the domestic electric market.

  17. Current Research in Affective Development.

    Science.gov (United States)

    Strayer, Janet

    1985-01-01

    Current research concerning affective development in infants and children is selectively reviewed. The focus of findings and discussion is on three general and related topics: (1) expression of emotion and affective interaction in infancy; (2) socialization and regulation of emotion; (3) comprehension of emotions and empathy with others by…

  18. Affective Development in University Education

    Science.gov (United States)

    Grootenboer, Peter

    2010-01-01

    There seems to be an increasing requirement for university courses and programs to develop students' affective qualities (beliefs, values, dispositions and attitudes). This study explored the ways academics determined what the desirable qualities were for their particular disciplines and the pedagogical strategies and approaches they used to…

  19. Application of neural networks to forecasting the CCT curves

    International Nuclear Information System (INIS)

    The paper presents methodology of modeling using neural networks of the relationship between the chemical composition and austenitising temperature, and the supercooled austenite transformation kinetics during the continuous cooling. The model worked out makes it possible to calculate a complete CCT diagram for the steel with a known chemical composition and analysis of the influence of particular elements on the characteristic points and transformation curves of supercooled austenite, and also the hardness resulting from cooling. It makes also possible forecasting of the structure developed in the steel as a result of cooling at a particular rate, by the quantitative description of the percentages of ferrite, pearlite, bainite and martensite with retained austenite. (author)

  20. Project of computer program for designing the steel with the assumed CCT diagram

    Directory of Open Access Journals (Sweden)

    S. Malara

    2007-01-01

    Full Text Available Purpose: The aim of this paper was developing a project of computer aided method for designing the chemicalcomposition of steel with the assumed CCT diagram.Design/methodology/approach: The purpose has been achieved in four stages. At the first stage characteristicpoints of CCT diagram have been determined. At the second stage neural networks have been developed, andnext CCT diagram terms of similarity have been worked out- at the third one. In the last one steel chemicalcomposition optimization method has been developed.Findings: The algorithm was created in this paper, that allowed to design the chemical composition of steelwith the assumed CCT diagram.Research limitations/implications: The created method for designing chemical compositions is limited byestablished ranges of mass concentrations of elements. The methodology demonstrated in the paper makes itpossible to add new grades of steel to the system.Practical implications: The method worked out may be used in computer steel selection systems for themachines parts exposed to heat treatment.Originality/value: The presented computer aided method makes use of neural networks, and may be used forselecting the steel with the required structure after heat treatment.

  1. Clean coal technologies---An international seminar: Seminar evaluation and identification of potential CCT markets

    International Nuclear Information System (INIS)

    The need for environmentally responsible electricity generation is a worldwide concern. Because coal is available throughout the world at a reasonable cost, current research is focusing on technologies that use coal with minimal environmental effects. The United States government is supporting research on clean coal technologies (CCTs) to be used for new capacity additions and for retrofits to existing capacity. To promote the worldwide adoption of US CCTs, the US Department of Energy, the US Agency for International Development, and the US Trade and Development Program sponsored a two-week seminar titled Clean Coal Technologies -- An International Seminar. Nineteen participants from seven countries were invited to this seminar, which was held at Argonne National Laboratory in June 1991. During the seminar, 11 US CCT vendors made presentations on their state-of-the-art and commercially available technologies. The presentations included technical, environmental, operational, and economic characteristics of CCTs. Information on financing and evaluating CCTs also was presented, and participants visited two CCT operating sites. The closing evaluation indicated that the seminar was a worthwhile experience for all participants and that it should be repeated. The participants said CCT could play a role in their existing and future electric capacity, but they agreed that more CCT demonstration projects were needed to confirm the reliability and performance of the technologies

  2. Clean coal technologies---An international seminar: Seminar evaluation and identification of potential CCT markets

    Energy Technology Data Exchange (ETDEWEB)

    Guziel, K.A.; Poch, L.A.; Gillette, J.L.; Buehring, W.A.

    1991-07-01

    The need for environmentally responsible electricity generation is a worldwide concern. Because coal is available throughout the world at a reasonable cost, current research is focusing on technologies that use coal with minimal environmental effects. The United States government is supporting research on clean coal technologies (CCTs) to be used for new capacity additions and for retrofits to existing capacity. To promote the worldwide adoption of US CCTs, the US Department of Energy, the US Agency for International Development, and the US Trade and Development Program sponsored a two-week seminar titled Clean Coal Technologies -- An International Seminar. Nineteen participants from seven countries were invited to this seminar, which was held at Argonne National Laboratory in June 1991. During the seminar, 11 US CCT vendors made presentations on their state-of-the-art and commercially available technologies. The presentations included technical, environmental, operational, and economic characteristics of CCTs. Information on financing and evaluating CCTs also was presented, and participants visited two CCT operating sites. The closing evaluation indicated that the seminar was a worthwhile experience for all participants and that it should be repeated. The participants said CCT could play a role in their existing and future electric capacity, but they agreed that more CCT demonstration projects were needed to confirm the reliability and performance of the technologies.

  3. Metodologia de baixo custo para levantamento de diagramas CCT em soldagem Low-cost methodology for obtaining CCT welding diagrams

    Directory of Open Access Journals (Sweden)

    Louriel Oliveira Vilarinho

    2010-09-01

    metallurgical problems, which is specific for each material and, therefore, demands dedicated and time-consuming study. Specifically, metallurgical transformations in the HAZ (Heat Affected Zone can occur and lead to microestructural changes such as grain growth, fragile structures presence, cracking, among others. The HAZ is a difficult region for studying due to its small dimensions, where its properties are defined basically by the base metal characteristics and the factors that affect the thermal cycle of the process. Thus, in order to overcome this limitation of the HAZ study, there are in the literature different proposes of HAZ-simulator machines, which uses the Joule effect for heating specific coupons that cool down by conduction and convection. This approach intends to simulate the thermal cycle in a "real" HAZ obtained in a "real" welding. Comercial simulators are available at very high costs. Therefore, the development of a low-cost machine is welcome. In a previous study, the proposition and construction of this machine, based on the modification of resistance spot welding equipment, was carried out and the first coupons were fabricated in a cylindrical geometry. Although the machine provides sufficient energy, the use of traditional coupons with cylindrical geometry presents restrictions of portraying the "real" case, i.e., the welding. In the cylindrical geometry option, the obtained thermal cycles do not present temperature gradients closer to the ones in "real" weldments. Hence, to overcome this limitation, finite elements modelling was carried out and different coupon geometries were simulated. The objective is to reach thermal cycles as close as possible to the ones obtained in a "real" situation. A database of different geometrical features was achieved by using the finite element analyses. This database was used as the input of model regression analyses by using statistical ANOVA. The empirical resulting model was employed as the input of an optimization

  4. Environmental Factors Affecting Preschoolers' Motor Development

    Science.gov (United States)

    Venetsanou, Fotini; Kambas, Antonis

    2010-01-01

    The process of development occurs according to the pattern established by the genetic potential and also by the influence of environmental factors. The aim of the present study was to focus on the main environmental factors affecting motor development. The review of the literature revealed that family features, such as socioeconomic status,…

  5. Project of neural network for steel grade selection with the assumed CCT diagram

    Directory of Open Access Journals (Sweden)

    S. Malara

    2008-04-01

    Full Text Available Purpose: The aim of this paper was developing a project of neural network for selection of steel grade with the specified CCT diagram – structure and of harness after heat treatment.Design/methodology/approach: The goal has been achieved in the following stages: at the first stage characteristic points of CCT diagram have been determined. At the second stage neural network has been developed and optimized.Findings: The neural network was developed in this paper, that allowed selection of steel grade with the assumed CCT diagram.Research limitations/implications: Created method for designing chemical compositions is limited by the established ranges of mass concentrations of elements. The methodology demonstrated in the paper makes it possible to add new steel grades to the system.Practical implications: The method worked out may be used in computer steel selection systems for the machine parts put to heat treatment.Originality/value: Presented computer aided method makes use of neural networks, and may be used for selecting the steel with the required structure after heat treatment.

  6. CCT, a Code to Automate the Design of Coupled Cavities

    CERN Document Server

    Smith, P D

    2000-01-01

    The CCT (Coupled Cavity Tuning) code automates the RF calculations and sizing of RF cavities for the CCL (Coupled Cavity Linac) structures of APT. It is planned to extend the code to the CCDTL (Coupled Cavity Drift Tube Linac). The CCT code controls the CCLFISH code, a member of the Poisson Superfish series of codes [1]. CCLFISH performs RF calculations and tunes the geometry of individual cavities, including an accelerating cavity (AC) and a coupling cavity (CC). CCT also relates the AC and CC by means of equations that describe the coupling slot between cavities. These equations account for the direct coupling, the next nearest neighbor coupling between adjacent AC's, and the frequency shifts in the AC and CC caused by the slot. Given design objectives of a coupling coefficient k, the pi/2 mode frequency, and the net frequency of the CC, the CCT code iterates to solve for the geometry of the AC and CC and the separation distance between them (this controls the slot size), satisfying the design objectives. T...

  7. The calculation of CCT diagrams for engineering steels

    OpenAIRE

    J. Trzaska; A. Jagiełło; L.A. Dobrzański

    2009-01-01

    Purpose: of this paper is to present numerical methods for calculation of CCT diagrams for engineering steels.Design/methodology/approach: The presented numerical methods for calculating the anisothermic diagrams of supercooled austenite are based on physical, statistical or artificial intelligence methods. In many cases input data are chemical composition and austenitising temperature. The results of calculations consist of temperature of the beginning and the end of particular transformatio...

  8. Cadmium affects retinogenesis during zebrafish embryonic development

    International Nuclear Information System (INIS)

    Ocular malformations are commonly observed in embryos of aquatic species after exposure to toxicants. Using zebrafish embryos as the model organism, we showed that cadmium exposure from sphere stage (4 hpf) to end of segmentation stage (24 hpf) induced microphthalmia in cadmium-treated embryos. Embryos with eye defects were then assessed for visual abilities. Cadmium-exposed embryos were behaviorally blind, showing hyperpigmentation and loss of camouflage response to light. We investigated the cellular basis of the formation of the small eyes phenotype and the induction of blindness by studying retina development and retinotectal projections. Retinal progenitors were found in cadmium-treated embryos albeit in smaller numbers. The number of retinal ganglion cells (RGC), the first class of retinal cells to differentiate during retinogenesis, was reduced, while photoreceptor cells, the last batch of retinal neurons to differentiate, were absent. Cadmium also affected the propagation of neurons in neurogenic waves. The neurons remained in the ventronasal area and failed to spread across the retina. Drastically reduced RGC axons and disrupted optic stalk showed that the optic nerves did not extend from the retina beyond the chiasm into the tectum. Our data suggested that impairment in neuronal differentiation of the retina, disruption in RGC axon formation and absence of cone photoreceptors were the causes of microphthalmia and visual impairment in cadmium-treated embryos

  9. Nutritional requirements of Zymomonas mobilis CCT 4494 for levan production

    Directory of Open Access Journals (Sweden)

    Fernanda Maria Pagane Guereschi Ernandes

    2011-06-01

    Full Text Available The aim of this work was to study the nutritional requirements of Zymomonas mobilis CCT 4494 for levan production in three chemically defined media. During the optimization of the fermentative process for the production of the exopolysaccharide, different concentrations of glucose, fructose and sucrose as carbon source and yeast extract as vitamin source were tested. Variations of incubation temperature and initial pH of the medium were observed. The results showed that medium containing 20.0% sucrose and 0.5% yeast extract, with initial pH of 7.0, incubated at 30°C gave a 43.0% yield of the biopolymer.

  10. CCT- and CRI-tuning of white light-emitting diodes using three-dimensional non-close-packed colloidal photonic crystals with photonic stop-bands.

    Science.gov (United States)

    Lai, Chun-Feng; Chang, Chung-Chieh; Wang, Ming-Jye; Wu, Mau-Kuen

    2013-07-01

    This study exhibited the correlated color temperature (CCT)- and color-rendering index (CRI)-tuning behavior of light emission from white light-emitting diodes (WLEDs) using three-dimensional non-close-packed (3D NCP) colloidal photonic crystals (CPhCs). The CCT of approximately 5300 K (characteristic of cold WLEDs) of white light propagated through the NCP CPhCs dropped to 3000 K (characteristic of warm WLEDs) because of the photonic stop-bands based on the photonic band structures of NCP CPhCs. This study successfully developed a novel technique that introduces lower-cost CCT- and CRI-tuning cold WLEDs with a CRI of over 90 that of warm WLEDs by using 3D NCP CPhCs. PMID:24104495

  11. Increased CCT-eta expression is a marker of latent and active disease and a modulator of fibroblast contractility in Dupuytren’s contracture

    OpenAIRE

    Satish, Latha; O’Gorman, David B; Johnson, Sandra; Raykha, Christina; Gan, Bing Siang; Wang, James H-C.; Kathju, Sandeep

    2013-01-01

    Dupuytren’s contracture (DC) is a fibroproliferative disorder of unknown etiology characterized by a scar-like contracture that develops in the palm and/or digits. We have previously reported that the eta subunit of the chaperonin containing T-complex polypeptide (CCT-eta) is increased in fibrotic wound healing, and is essential for the accumulation of α-smooth muscle actin (α-SMA) in fibroblasts. The purpose of this study was to determine if CCT-eta is similarly implicated in the aberrant fi...

  12. The calculation of CCT diagrams for engineering steels

    Directory of Open Access Journals (Sweden)

    J. Trzaska

    2009-09-01

    Full Text Available Purpose: of this paper is to present numerical methods for calculation of CCT diagrams for engineering steels.Design/methodology/approach: The presented numerical methods for calculating the anisothermic diagrams of supercooled austenite are based on physical, statistical or artificial intelligence methods. In many cases input data are chemical composition and austenitising temperature. The results of calculations consist of temperature of the beginning and the end of particular transformation, the volume fraction of structural components and hardness of steel after heat treatment.Findings: Numerical methods are an alternative to experimental measurement in providing the material data required for heat treatment process simulation.Research limitations/implications: All presented methods for calculation of CCT diagrams for engineering steels are limited by ranges of mass concentrations of elements.Practical implications: All presented methods may be used in computer steel selection systems for machines parts manufactured from engineering steels subjected to heat treatment.Originality/value: The presented methods can be used for selecting steel with required structure after heat treatment.

  13. Policy factors affecting broadband development in Poland

    DEFF Research Database (Denmark)

    Henten, Anders; Windekilde, Iwona Maria

    2014-01-01

    gradually change the previous balance of power. The specific problem of the Polish market is its very poor infrastructure development and the lack of competitors on the fixed market. This translates into limited access to services for end users particularly in the rural areas. A much lower level of......’s telecommunications market with the European market. The market reflects all the global trends, a gradually growing significance of mobile telecommunications services, broadband Internet access, construction of offers directed towards clients’ needs, and a strong trend towards market consolidation, which will...... telecommunications network development in Poland than other countries in the European Union is the reason that the circumstances and also the effects of the implementation of some solutions of the EU regulation model are different in Poland than in the most developed EU countries. The aim of the paper is to examine...

  14. Input and output constraints affecting irrigation development

    Science.gov (United States)

    Schramm, G.

    1981-05-01

    In many of the developing countries the expansion of irrigated agriculture is used as a major development tool for bringing about increases in agricultural output, rural economic growth and income distribution. Apart from constraints imposed by water availability, the major limitations considered to any acceleration of such programs are usually thought to be those of costs and financial resources. However, as is shown on the basis of empirical data drawn from Mexico, in reality the feasibility and effectiveness of such development programs is even more constrained by the lack of specialized physical and human factors on the input and market limitations on the output side. On the input side, the limited availability of complementary factors such as, for example, truly functioning credit systems for small-scale farmers or effective agricultural extension services impose long-term constraints on development. On the output side the limited availability, high risk, and relatively slow growth of markets for high-value crops sharply reduce the usually hoped-for and projected profitable crop mix that would warrant the frequently high costs of irrigation investments. Three conclusions are drawn: (1) Factors in limited supply have to be shadow-priced to reflect their high opportunity costs in alternative uses. (2) Re-allocation of financial resources from immediate construction of projects to longer-term increase in the supply of scarce, highly-trained manpower resources are necessary in order to optimize development over time. (3) Inclusion of high-value, high-income producing crops in the benefit-cost analysis of new projects is inappropriate if these crops could potentially be grown in already existing projects.

  15. Current Comparative Table (CCT) automates customized searches of dynamic biological databases

    Science.gov (United States)

    Landsteiner, Benjamin R.; Olson, Michael R.; Rutherford, Robert

    2005-01-01

    The Current Comparative Table (CCT) software program enables working biologists to automate customized bioinformatics searches, typically of remote sequence or HMM (hidden Markov model) databases. CCT currently supports BLAST, hmmpfam and other programs useful for gene and ortholog identification. The software is web based, has a BioPerl core and can be used remotely via a browser or locally on Mac OS X or Linux machines. CCT is particularly useful to scientists who study large sets of molecules in today's evolving information landscape because it color-codes all result files by age and highlights even tiny changes in sequence or annotation. By empowering non-bioinformaticians to automate custom searches and examine current results in context at a glance, CCT allows a remote database submission in the evening to influence the next morning's bench experiment. A demonstration of CCT is available at and the open source software is freely available from . PMID:15980582

  16. Comparison of Critical Trajectory Methods for Direct CCT Computation for Transient Stability

    Science.gov (United States)

    Priyadi, Ardyono; Yorino, Naoto; Sasaki, Yutaka; Tanaka, Masahide; Fujiwara, Takuma; Zoka, Yoshifumi; Kakui, Hironori; Takeshita, Mitsuhiro

    This paper studies new techniques for critical trajectory method, a recent new method proposed by the authors for obtaining critical clearing time (CCT) for transient stability analysis. A specific feature of the proposed method lies in its ability to provide exact CCT without approximations since no such methods have existed so far. The method is based on the computation of the critical trajectory, which is defined as the trajectory that starts from a point on a fault-on trajectory at CCT and reaches an end point. There are a few possible methods for the treatment of the end point conditions, computational performances of the methods are investigated in terms of accuracy of CCT and computational efficiency. It is shown that the proposed methods successfully provide the exact CCT that agrees with the conventional numerical simulation method.

  17. Polystyrene nanoparticles affect Xenopus laevis development

    Energy Technology Data Exchange (ETDEWEB)

    Tussellino, Margherita; Ronca, Raffaele [University of Naples Federico II, Department of Biology (Italy); Formiggini, Fabio [Italian Institute of Technology, Center for Advanced Biomaterials for Health Care IIT@CRIB (Italy); Marco, Nadia De [University of Naples Federico II, Department of Biology (Italy); Fusco, Sabato; Netti, Paolo Antonio [Italian Institute of Technology, Center for Advanced Biomaterials for Health Care IIT@CRIB (Italy); Carotenuto, Rosa, E-mail: rosa.carotenuto@unina.it [University of Naples Federico II, Department of Biology (Italy)

    2015-02-15

    Exposing living organisms to nanoparticulates is potentially hazardous, in particular when it takes place during embryogenesis. In this investigation, we have studied the effects of 50-nm-uncoated polystyrene nanoparticles (PSNPs) as a model to investigate the suitability of their possible future employments. We have used the standardized Frog Embryo Teratogenesis Assay-Xenopus test during the early stages of larval development of Xenopus laevis, and we have employed either contact exposure or microinjections. We found that the embryos mortality rate is dose dependent and that the survived embryos showed high percentage of malformations. They display disorders in pigmentation distribution, malformations of the head, gut and tail, edema in the anterior ventral region, and a shorter body length compared with sibling untreated embryos. Moreover, these embryos grow more slowly than the untreated embryos. Expressions of the mesoderm markers, bra (T-box Brachyury gene), myod1 (myogenic differentiation1), and of neural crest marker sox9 (sex SRY (determining region Y-box 9) transcription factor sox9), are modified. Confocal microscopy showed that the nanoparticles are localized in the cytoplasm, in the nucleus, and in the periphery of the digestive gut cells. Our data suggest that PSNPs are toxic and show a potential teratogenic effect for Xenopus larvae. We hypothesize that these effects may be due either to the amount of NPs that penetrate into the cells and/or to the “corona” effect caused by the interaction of PSNPs with cytoplasm components. The three endpoints of our study, i.e., mortality, malformations, and growth inhibition, suggest that the tests we used may be a powerful and flexible bioassay in evaluating pollutants in aquatic embryos.

  18. Affective Development in Advanced Old Age: Analyses of Terminal Change in Positive and Negative Affect

    Science.gov (United States)

    Schilling, Oliver K.; Wahl, Hans-Werner; Wiegering, Sarah

    2013-01-01

    Late-life development of affect may unfold terminal changes that are driven more by end-of-life processes and not so much by time since birth. This study aimed to explore time-to-death-related effects in measures of affect in a sample of the very old. We used longitudinal data (2 measurement occasions: 2002 and 2003) from 140 deceased…

  19. Rearing environment affects development of the immune system in neonates

    NARCIS (Netherlands)

    Inman, C.F.; Haverson, K.; Konstantinov, S.R.; Jones, P.H.; Harris, C.; Smidt, H.; Miller, B.; Bailey, M.; Stokes, C.

    2010-01-01

    P>Early-life exposure to appropriate microbial flora drives expansion and development of an efficient immune system. Aberrant development results in increased likelihood of allergic disease or increased susceptibility to infection. Thus, factors affecting microbial colonization may also affect th

  20. A round-robin test with thermal simulation of the welding HAZ to draw CCT diagrams: a need for harmonized procedures and microconstituent terminologies

    OpenAIRE

    Américo Scotti; Huijun Li; Rosa M. Miranda

    2014-01-01

    Thermal simulations of heat affected zone (HAZ) have been widely used. This is an economic expedite process for phase transformation evaluations in steels when subjected to weld thermal cycles as well as to draw continuous cooling transformation (CCT) diagrams. Different approaches for the simulation and parameter settings have been used by several researchers, yet leading to not always even results. Thus, it was proposed a round-robin test trial performed by different laboratories, aiming to...

  1. The Development of the Meta-Affective Trait Scale

    Science.gov (United States)

    Uzuntiryaki-Kondakci, Esen; Kirbulut, Zubeyde Demet

    2016-01-01

    The purpose of this study was to develop a Meta-Affective Trait Scale (MATS) to measure the meta-affective inclinations related to emotions that students have while they are studying for their classes. First, a pilot study was performed with 380 10th-grade students. Results of the exploratory factor analysis supported a two-factor structure of the…

  2. Strategies for Developing Effective Teaching Skills in the Affective Domain

    Science.gov (United States)

    Hansen, Ken

    2009-01-01

    Perhaps more than any other academic discipline, physical education holds the highest potential for teaching affective skills. By its very nature, the typical physical education setting offers countless teachable moments and opportunities to capitalize on the development of affective skills. The seeming lack of attention given to affective…

  3. CONSUMER CULTURE THEORY (CCT JÁ É UMA ESCOLA DE PENSAMENTO EM MARKETING?

    Directory of Open Access Journals (Sweden)

    Brunno Fernandes da Silva Gaião

    2012-05-01

    Full Text Available The 1980s brought an alternative view to the positivist predominant current in consumer research field: Consumer Culture Theory CCT, which assumes an epistemological orientation based on interpretivism and qualitative research. Given the prominence achieved by CCT it’s raised the follow question: Consumer Culture Theory can be considered an autonomous marketing school of thought? Guided by three fundamental criteria for qualifying a school of thought (academic recognition, body of knowledge and contributions, a desk research was conducted, based on journals and papers in the field and in a research corpus built from the references included in the seminal text Consumer Culture Theory (CCT: Twenty Years of Research. Conclusion is that CCT meets the criteria adopted in this research and, thus, can be considered an autonomous marketing school of thought within the field of consumer research.

  4. Employment of neural networks for analysis of chemical composition and cooling rate effect on CCT diagrams shape

    International Nuclear Information System (INIS)

    The paper presents possibility of employment of the original supercooled austenite transformation anisothermic diagrams forecasting method for analysis of the chemical composition effect on the CCT diagrams shape. The developed model makes it possible to substitute computer simulation for the costly and time consuming experiments. The information derived from calculations make it possible to plot diagrams illustrating the effects of the particular elements or pairs of elements, as well as cooling rate and/or austenitizing temperature, on any temperature or time describing transformations in steel during its continuous cooling. Evaluation is also possible of the effect of the aforementioned factors on hardness and fractions of the particular structural constituents. (author)

  5. CONSUMER CULTURE THEORY (CCT) JÁ É UMA ESCOLA DE PENSAMENTO EM MARKETING?

    OpenAIRE

    Brunno Fernandes da Silva Gaião; Ildembergue Leite de Souza; André Luiz M. de Souza Leão

    2012-01-01

    The 1980s brought an alternative view to the positivist predominant current in consumer research field: Consumer Culture Theory CCT), which assumes an epistemological orientation based on interpretivism and qualitative research. Given the prominence achieved by CCT it’s raised the follow question: Consumer Culture Theory can be considered an autonomous marketing school of thought? Guided by three fundamental criteria for qualifying a school of thought (academic recognition, body of knowledge ...

  6. Scale Development: Factors Affecting Diet, Exercise, and Stress Management (FADESM)

    OpenAIRE

    Nitzke Susan; Brown Roger; Chang Mei-Wei

    2008-01-01

    Abstract Background The objective of this study was to develop scales measuring personal and environmental factors that affect dietary fat intake behavior, physical activity, and stress management in low-income mothers. Methods FADESM (factors affecting diet, exercise, and stress management) scales were developed using the Social Cognitive Theory to measure personal (outcome expectancies, self-efficacy, emotional coping response) and environmental (physical environment, social environment, si...

  7. A round-robin test with thermal simulation of the welding HAZ to draw CCT diagrams: a need for harmonized procedures and microconstituent terminologies

    Directory of Open Access Journals (Sweden)

    Américo Scotti

    2014-09-01

    Full Text Available Thermal simulations of heat affected zone (HAZ have been widely used. This is an economic expedite process for phase transformation evaluations in steels when subjected to weld thermal cycles as well as to draw continuous cooling transformation (CCT diagrams. Different approaches for the simulation and parameter settings have been used by several researchers, yet leading to not always even results. Thus, it was proposed a round-robin test trial performed by different laboratories, aiming to evidence potential sources of error or inadequacy of the approaches. A High Strength Low Alloy (HSLA steel was used as a case study. Despite the limited number of tests, the results show low robustness when comparing the outcomes from the different laboratories and point out for the need to take three actions. The first one is to implement a cooperative and multi-institutional program to assess the effect of relevant simulation parameters, such as the heating rate and holding time at peak temperature, on the final microstructure and transformation temperatures as well as on the hardness for a given cooling rate. The second is to propose calibration procedures for the simulation and measurement systems. The third action is to stimulate experts in this area to develop a guideline of terminology for constituents in the heat affected zone of ferritic steels.

  8. Environmental issues affecting clean coal technology deployment

    Energy Technology Data Exchange (ETDEWEB)

    Miller, M.J. [Electric Power Research Inst., Palo Alto, CA (United States)

    1997-12-31

    The author outlines what he considers to be the key environmental issues affecting Clean Coal Technology (CCT) deployment both in the US and internationally. Since the international issues are difficult to characterize given different environmental drivers in various countries and regions, the primary focus of his remarks is on US deployment. However, he makes some general remarks, particularly regarding the environmental issues in developing vs. developed countries and how these issues may affect CCT deployment. Further, how environment affects deployment depends on which particular type of clean coal technology one is addressing. It is not the author`s intention to mention many specific technologies other than to use them for the purposes of example. He generally categorizes CCTs into four groups since environment is likely to affect deployment for each category somewhat differently. These four categories are: Precombustion technologies such as coal cleaning; Combustion technologies such as low NOx burners; Postcombustion technologies such as FGD systems and postcombustion NOx control; and New generation technologies such as gasification and fluidized bed combustion.

  9. Influence of plastic deformation on CCT-diagrams of low-carbon and medium-carbon TRIP-steels

    Directory of Open Access Journals (Sweden)

    M. Opiela

    2008-07-01

    Full Text Available Purpose: The aim of the paper is to investigate the influence of plastic deformation and cooling conditions on a structure and a shape of CCT-diagrams of new-developed TRIP-aided microalloyed steels.Design/methodology/approach: The diagrams of undeformed and plastically-deformed supercooled austenite transformations for low-carbon and medium-carbon microalloyed steels were determined. A part of the specimens were austenitized at a temperature of 1100°C, then slowly cooled to 900°C and next cooled to ambient temperature with a various rate from 1 to 300°C/s. To investigate the influence of plastic deformation on a shape of CCT (Continuous Cooling Transformations diagrams, another part of the specimens were 50% deformed at 900°C and cooled to ambient temperature with a rate from 88 to 1°C/s. The DIL805A/D dilatometer, with a LVDT-type measuring head, was used to carry out dilatometric tests.Findings: It was found that a shape of CCT diagrams of elaborated steels predisposes them for multiphase sheets manufacturing. The new-developed steels possess ferritic and bainitic bays put forward to short times and pearlitic regions put aside. However, cooling the steel with a constant rate from austenitizing temperature doesn’t lead to obtaining proper participation of ferrite. Plastic deformation of steel has a profitable influence on the shape of supercooled austenite curves. The region of γ→α transformation is translated to the left at simultaneous raise of start temperature of austenite into ferrite transformation resulting in definitely higher ferrite fraction. Moreover, significant refinement of microstructure in a whole range of cooling rate was also obtained.Research limitations/implications: To increase the ferrite fraction, modification of the cooling after hot-working finishing should be applied. In the fist stage, steel should be rapidly cooled in order to enter the range of γ→α transformation and successively slowly cooled in a

  10. Function if Cooperative Learning in Developing Positive Affect

    Institute of Scientific and Technical Information of China (English)

    佟玉平

    2008-01-01

    This paper focus on the function of cooperative learning in developing positive affect, Including reducing anxiety, increasing motivation, facilitating the development of positive attitudes toward learning and language learning, promoting serf- esteem, as well as supporting different learning styles and encouraging perseverance in the difficult and confusing process of learning a foreign language.

  11. Development and psychometric validation of the verbal affective memory test

    DEFF Research Database (Denmark)

    Jensen, Christian Gaden; Hjordt, Liv V; Stenbæk, Dea S; Andersen, Emil; Back, Silja K; Lansner, Jon; Hageman, Ida; Dam, Henrik; Nielsen, Anna P; Knudsen, Gitte M; Frokjaer, Vibe G; Hasselbalch, Steen G

    We here present the development and validation of the Verbal Affective Memory Test-24 (VAMT-24). First, we ensured face validity by selecting 24 words reliably perceived as positive, negative or neutral, respectively, according to healthy Danish adults' valence ratings of 210 common and non......-taboo words. Second, we studied the test's psychometric properties in healthy adults. Finally, we investigated whether individuals diagnosed with Seasonal Affective Disorder (SAD) differed from healthy controls on seasonal changes in affective recall. Recall rates were internally consistent and reliable and...... converged satisfactorily with established non-affective verbal tests. Immediate recall (IMR) for positive words exceeded IMR for negative words in the healthy sample. Relatedly, individuals with SAD showed a significantly larger decrease in positive recall from summer to winter than healthy controls...

  12. Potential for thermal coal and Clean Coal Technology (CCT) in the Asia-Pacific

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, C.J.; Long, S.

    1991-11-22

    The Coal Project was able to make considerable progress in understanding the evolving energy situation in Asia and the future role of coal and Clean Coal Technologies. It is clear that there will be major growth in consumption of coal in Asia over the next two decades -- we estimate an increase of 1.2 billion metric tons. Second, all governments are concerned about the environmental impacts of increased coal use, however enforcement of regulations appears to be quite variable among Asian countries. There is general caution of the part of Asian utilities with respect to the introduction of CCT's. However, there appears to be potential for introduction of CCT's in a few countries by the turn of the century. It is important to emphasize that it will be a long term effort to succeed in getting CCT's introduced to Asia. The Coal Project recommends that the US CCT program be expanded to allow the early introduction of CCT's in a number of countries.

  13. The Olig family affects central nervous system development and disease

    Institute of Scientific and Technical Information of China (English)

    Botao Tan; Jing Yu; Ying Yin; Gongwei Jia; Wei Jiang; Lehua Yu

    2014-01-01

    Neural cell differentiation and maturation is a critical step during central nervous system devel-opment. The oligodendrocyte transcription family (Olig family) is known to be an important factor in regulating neural cell differentiation. Because of this, the Olig family also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. This review investigates the role of the Olig family in central nervous system develop-ment and related diseases.

  14. Professional Group Development Trainers’ Personality Characteristics and Affective Profiles

    Directory of Open Access Journals (Sweden)

    Max eRapp Ricciardi

    2014-10-01

    Full Text Available Background: The Development of Groups and Leaders (UGL, provided by the Swedish National Defence College and mentored by UGL-trainers, is one of the most popular management programs among civilians in Sweden. However, there is a lack of scientific evidence regarding the training. We used the affective profile model (i.e., the combination of positive, PA, and negative affect, NA to mapp important markers of empowerment, self-awareness, adaptive coping skills, and maturity among the UGL-trainers. The aims were: (1 to compare profiles between UGL-trainers and managers/supervisors and (2 to investigate differences in personal characteristics.Method: UGL-trainers (N = 153 and the comparison group (104 Swedish Chiefs of Police completed an online survey on optimism, self-esteem, locus of control, and affect. The four profiles are: self-fulfilling (high PA, low NA, high affective (high PA, high NA, low affective (high PA, low NA, and self-destructive (low PA, high NA,Results: The self-fulfilling profile was more common among UGL-trainers (25.70% than among Chiefs of Police (19.20%. UGL-trainers, compared to Chiefs of Police, were more likely to express a self-fulling than a low affective profile (OR=2.22, p < .05 and a high affective than a low affective profile (OR=1.43, p <.001. UGL-trainers with a self-fulfilling profile, compared to those with a self-destructive profile, scored higher in optimism, higher in self-esteem, and lower in external locus of control. Conclusions: The probability of self-fulfilment rather than low affectivity was higher among UGL-trainers. Self-fulfilment was associated to markers of self-awareness and adaptive coping skills. However, the most common profile was the low affective, which is associated to low performance during stress, low degree of personal development, low degree of purpose in life, and low resilience. Hence, it might be important for UGL-trainers to have a continuos training in awareness after

  15. Investigating the factors affecting the investment decision in residential development.

    OpenAIRE

    Narang, Somil

    2007-01-01

    The purpose of this project is to provide a rare insight into the motivation behind residential property investors when looking to purchase an apartment. The factors driving demand preferences for housing are constantly changing, difficult to measure, and often deemed to be a complex bundle of attributes. The project attempts to answer the following questions: What are the factors affecting the investment decision in a Residential Development? To identify the significance and weight of su...

  16. Development of brain mechanisms for processing affective touch

    OpenAIRE

    Malin eBjornsdotter; Ilanit eGordon; Pelphrey, Kevin A.; Håkan eOlausson; Martha eKaiser

    2014-01-01

    Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI) to study brain responses to soft brush stroking of both glabrous (palm) and hairy (forearm) skin in healthy children (5-13 years), adolescents (14-17 years), and adults (25-35 years). Adult-defined regions-of-interests in the primary somatosensory cortex (SI), secondary...

  17. Nutritional components affecting skeletal development in fish larvae

    OpenAIRE

    Cahu, Chantal; Zambonino, Jose-luis; Takeuchi, Toshio

    2003-01-01

    Marine fish larvae undergo major functional and morphological changes during the developmental stages and several factors can interfere with the normal development of larvae and affect fry quality. Skeletal malformations, such as spinal malformation-scoliosis, lordosis, coiled vertebral column-, missing or additional fin rays, bending opercle or jaw malformations, are frequently observed in hatchery-reared larvae. This paper reviews the effects of some nutritional components on skeletal devel...

  18. Survey of state water laws affecting coal slurry pipeline development

    Energy Technology Data Exchange (ETDEWEB)

    Rogozen, M.B.

    1980-11-01

    This report summarizes state water laws likely to affect the development of coal slurry pipelines. It was prepared as part of a project to analyze environmental issues related to energy transportation systems. Coal slurry pipelines have been proposed as a means to expand the existing transportation system to handle the increasing coal shipments that will be required in the future. The availability of water for use in coal slurry systems in the coal-producing states is an issue of major concern.

  19. Older Siblings Affect Gut Microbiota Development in Early Childhood

    DEFF Research Database (Denmark)

    Laursen, Martin Frederik; Zachariassen, Gitte; Bahl, Martin Iain;

    Background: Evidence suggests that early life infections, presence of older siblings and furred pets in the household affect the risk of developing allergic diseases through altered microbial exposure. Recently, low gut microbial diversity during infancy has also been linked with later developmen......-associated gut microbial changes influence development of allergies later in childhood.   The work has recently (July 2015) been accepted for publication in BMC Microbiology...... early childhood, which could contribute to the substantiation of the hygiene hypothesis. However, no associations were found between gut microbiota and atopic symptoms of eczema and asthmatic bronchitis during early childhood and thus further studies are required to elucidate whether sibling...

  20. The Factors that Affect Science Teachers' Participation in Professional Development

    Science.gov (United States)

    Roux, Judi Ann

    Scientific literacy for our students and the possibilities for careers available in Science, Technology, Engineering, and Mathematics (STEM) areas are important topics for economic growth as well as global competitiveness. The achievement of students in science learning is dependent upon the science teachers' effectiveness and experienced science teachers depend upon relevant professional development experiences to support their learning. In order to understand how to improve student learning in science, the learning of science teachers must also be understood. Previous research studies on teacher professional development have been conducted in other states, but Minnesota science teachers comprised a new and different population from those previously studied. The purpose of this two-phase mixed methods study was to identify the current types of professional development in which experienced, Minnesota secondary science teachers participated and the factors that affect their participation in professional development activities. The mixed-methods approach s utilized an initial online survey followed by qualitative interviews with five survey respondents. The results of the quantitative survey and the qualitative interviews indicated the quality of professional development experiences and the factors which affected the science teachers' participation in professional development activities. The supporting and inhibiting factors involved the availability of resources such as time and money, external relationships with school administrators, teacher colleagues, and family members, and personal intrinsic attributes such as desires to learn and help students. This study also describes implications for science teachers, school administrators, policymakers, and professional development providers. Recommendations for future research include the following areas: relationships between and among intrinsic and extrinsic factors, science-related professional development activities

  1. Development of affective modelling competencies in primary school learners

    Directory of Open Access Journals (Sweden)

    Piera Biccard

    2011-10-01

    Full Text Available Learner affect and beliefs about mathematics are complex and multifaceted aspects of mathematical learning. Traditional teaching and learning approaches in mathematics education often result in problematic beliefs about mathematics. Since beliefs influence what learners learn and how they deal with learning mathematics, it is essential that the roles of beliefs and affect in mathematics classrooms are carefully examined. In solving modelling problems, learners and teachers take on new roles in the classroom: learners are placed in an active, self-directing situation in which they solve real-world problems. When learners engage in modelling tasks, they display and integrate cognitive, meta-cognitive and affective competencies. A modelling approach therefore allows one to detect learner beliefs in an authentic learning environment. Will this environment lead to students having more positive and productive dispositions towards mathematics? This article presents partial results of a study documenting the development of modelling competencies in learners working in groups over a period of 12 weeks. Through a design research approach, 12 learners working in groups solved three modelling problems, and transcriptions of learner interactions, questionnaires and informal interviews revealed that learner beliefs improved over this short period when exposed to modelling tasks. The results are encouraging, and may provide mathematics education with an avenue to develop more positive learner beliefs in mathematics.

  2. TRUE COLORS: LEDS AND THE RELATIONSHIP BETWEEN CCT, CRI, OPTICAL SAFETY, MATERIAL DEGRADATION, AND PHOTOBIOLOGICAL STIMULATION

    Energy Technology Data Exchange (ETDEWEB)

    Royer, Michael P.

    2014-08-30

    This document analyzes the optical, material, and photobiological hazards of LED light sources compared to conventional light sources. It documents that LEDs generally produce the same amount of blue light, which is the primary contributor to the risks, as other sources at the same CCT. Duv may have some effect on the amount of blue light, but CRI does not.

  3. How Stock Markets Development Affect Endogenous Growth Theory

    Directory of Open Access Journals (Sweden)

    Najeb Masoud

    2013-10-01

    Full Text Available This paper can bedescribed as a significant exploratory study that will provide a significantcontribution to knowledge to consider crucial issues which need to be barriersto understanding or a temptation/ requirement to judge some practices as‘better’ than others for stock market development effective approach andimplement successful stock market performance and economic growth. Recentanalysis of the link between financial development and growth, gained frominsights acquired as a result of using the technique of endogenous growthmodels, has illustrated that growth without exogenous technical progress andthat growth rates could be related to technology, income distribution andinstitutional arrangements. This provides the theoretical background thatempirical studies have lacked; illustrating that financial intermediationaffects the level of economic growth. Resulting models have provided newimpetus to empirical research of the effects of financial development. Thebirth of the new endogenous growth theory has facilitated the development ofimproved growth models where the long-term rate could be affected by a numberof elements. These included technology, education and health policies in theprocess of economic development, capital accumulation, government policies andinstitutional activities in the role of financial development in economicgrowth.

  4. Chaperonin containing T-complex polypeptide subunit eta (CCT-eta is a specific regulator of fibroblast motility and contractility.

    Directory of Open Access Journals (Sweden)

    Latha Satish

    Full Text Available Integumentary wounds in mammalian fetuses heal without scar; this scarless wound healing is intrinsic to fetal tissues and is notable for absence of the contraction seen in postnatal (adult wounds. The precise molecular signals determining the scarless phenotype remain unclear. We have previously reported that the eta subunit of the chaperonin containing T-complex polypeptide (CCT-eta is specifically reduced in healing fetal wounds in a rabbit model. In this study, we examine the role of CCT-eta in fibroblast motility and contractility, properties essential to wound healing and scar formation. We demonstrate that CCT-eta (but not CCT-beta is underexpressed in fetal fibroblasts compared to adult fibroblasts. An in vitro wound healing assay demonstrated that adult fibroblasts showed increased cell migration in response to epidermal growth factor (EGF and platelet derived growth factor (PDGF stimulation, whereas fetal fibroblasts were unresponsive. Downregulation of CCT-eta in adult fibroblasts with short inhibitory RNA (siRNA reduced cellular motility, both basal and growth factor-induced; in contrast, siRNA against CCT-beta had no such effect. Adult fibroblasts were more inherently contractile than fetal fibroblasts by cellular traction force microscopy; this contractility was increased by treatment with EGF and PDGF. CCT-eta siRNA inhibited the PDGF-induction of adult fibroblast contractility, whereas CCT-beta siRNA had no such effect. In each of these instances, the effect of downregulating CCT-eta was to modulate the behavior of adult fibroblasts so as to more closely approximate the characteristics of fetal fibroblasts. We next examined the effect of CCT-eta modulation on alpha-smooth muscle actin (alpha-SMA expression, a gene product well known to play a critical role in adult wound healing. Fetal fibroblasts were found to constitutively express less alpha-SMA than adult cells. Reduction of CCT-eta with siRNA had minimal effect on cellular

  5. Beneficial Microbes Affect Endogenous Mechanisms Controlling Root Development.

    Science.gov (United States)

    Verbon, Eline H; Liberman, Louisa M

    2016-03-01

    Plants have incredible developmental plasticity, enabling them to respond to a wide range of environmental conditions. Among these conditions is the presence of plant growth-promoting rhizobacteria (PGPR) in the soil. Recent studies show that PGPR affect Arabidopsis thaliana root growth and development by modulating cell division and differentiation in the primary root and influencing lateral root development. These effects lead to dramatic changes in root system architecture that significantly impact aboveground plant growth. Thus, PGPR may promote shoot growth via their effect on root developmental programs. This review focuses on contextualizing root developmental changes elicited by PGPR in light of our understanding of plant-microbe interactions and root developmental biology. PMID:26875056

  6. Development of brain mechanisms for processing affective touch

    Directory of Open Access Journals (Sweden)

    Malin eBjornsdotter

    2014-02-01

    Full Text Available Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI to study brain responses to soft brush stroking of both glabrous (palm and hairy (forearm skin in healthy children (5-13 years, adolescents (14-17 years and adults (25-35 years. Adult-defined regions-of-interests in the primary somatosensory cortex (SI, secondary somatosensory cortex (SII, insular cortex and right posterior superior temporal sulcus (pSTS were significantly and similarly activated in all age groups. Whole-brain analyses revealed that responses in the ipsilateral SII were positively correlated with age in both genders, and that responses in bilateral regions near the pSTS correlated significantly and strongly with age in females but not in males. These results suggest that brain mechanisms associated with both sensory-discriminative and affective-motivational aspects of touch are largely established in school-aged children, and that there is a general continuing maturation of SII and a female-specific increase in pSTS sensitivity with age. Our work establishes a groundwork for future comparative studies of tactile processing in developmental disorders characterized by disrupted social perception such as autism.

  7. STS-52 PS MacLean, backup PS Tryggvason, and PI pose on JSC's CCT flight deck

    Science.gov (United States)

    1992-01-01

    STS-52 Columbia, Orbiter Vehicle (OV) 102, Canadian Payload Specialist (PS) Steven G. MacLean (left) and backup Payload Specialist Bjarni V. Tryggvason (right) take a break from a camera training session in JSC's Crew Compartment Trainer (CCT). The two Canadian Space Agency (CSA) representatives pose on the CCT's aft flight deck with Canadian scientist David Zimick, the principal investigator (PI) for the materials experiment in low earth orbit (MELEO). MELEO is a component of the CANEX-2 experiment package, manifest to fly on the scheduled October 1992 STS-52 mission. The CCT is part of the shuttle Mockup and Integration Laboratory (MAIL) Bldg 9NE.

  8. Factors affecting the insurance sector development: Evidence from Albania

    Directory of Open Access Journals (Sweden)

    Eglantina Zyka

    2014-03-01

    Full Text Available In this paper we explore factors potentially affecting the size of Albanian insurance market, over the period 1999 to 2009. The results of co- integration regression show that GDP and fraction urban population, both one lagged value, size of population and paid claims, both at contemporary value, have significant positive effect on aggregate insurance premium in Albania while the market share of the largest company in the insurance market, one lagged value, has significant negative effect on aggregate insurance premiums. Granger causality test shows statistically significance contribution of GDP growth to insurance premium growth, GDP drives insurance premium growth but not vice versa. The Albanian insurance market is under development, indicators as: insurance penetration, premium per capita, ect are still at low level and this can justify the insignificant role of the insurance in the economy

  9. Economic and geographic factors affecting the development of Greater Baku

    Directory of Open Access Journals (Sweden)

    Vusat AFANDIYEV

    2014-12-01

    Full Text Available Globally, the responsible factors for the ongoing development of urbanization are the high speed of population growth, and the mass migration of humans to cities and large urban areas. In most countries, this process resulted in the emergence of ‘pseudo-urbanization’ which is difficult to be regulated. The purpose of the carried researches to determine the development priorities in the territory of Greater Baku – the capital city of the Republic of Azerbaijan; to define the problems that take place in this connection; and to develop ways of elimination of these problems. The reason of taking Baku as a research area is connected with some of the factors. Firstly, studies on Baku have been conducted based on the Soviet geographical and urban planning school and their methods for a long period. In this regard, it is necessary to carry out research in this field based on the principles adopted in most countries. Secondly, since 1992, the intensive accumulation of population in the territory of the capital city and the surrounding areas is being observed because of socio-economic problems. As a result, the process of pseudo-urbanization intensified, entailing a densely-populated area. Thirdly, low-rise buildings still continue to exist in the large areas within the territory of Baku, and they are not associated with the functional structure of the city. This situation creates many challenges, particularly in terms of density growth and effective use of the city’s territory. Finally, numerous new buildings have been constructed in the residential areas of Baku in recent years, and this may entailserious problems in water supply, energy provision, and utilities. The study is carried out referring to previous works of researchers, statistic data, and the results of the population census conducted in 1959-2009.The practical significance of the scientific work is that positive and negative factors affecting the further development of Greater Baku

  10. Spaceflight Affects Postnatal Development of the Aortic Wall in Rats

    Directory of Open Access Journals (Sweden)

    Shin-ichiro Katsuda

    2014-01-01

    Full Text Available We investigated effect of microgravity environment during spaceflight on postnatal development of the rheological properties of the aorta in rats. The neonate rats were randomly divided at 7 days of age into the spaceflight, asynchronous ground control, and vivarium control groups (8 pups for one dam. The spaceflight group rats at 9 days of age were exposed to microgravity environment for 16 days. A longitudinal wall strip of the proximal descending thoracic aorta was subjected to stress-strain and stress-relaxation tests. Wall tensile force was significantly smaller in the spaceflight group than in the two control groups, whereas there were no significant differences in wall stress or incremental elastic modulus at each strain among the three groups. Wall thickness and number of smooth muscle fibers were significantly smaller in the spaceflight group than in the two control groups, but there were no significant differences in amounts of either the elastin or collagen fibers among the three groups. The decreased thickness was mainly caused by the decreased number of smooth muscle cells. Plastic deformation was observed only in the spaceflight group in the stress-strain test. A microgravity environment during spaceflight could affect postnatal development of the morphological and rheological properties of the aorta.

  11. Spaceflight affects postnatal development of the aortic wall in rats.

    Science.gov (United States)

    Katsuda, Shin-ichiro; Yamasaki, Masao; Waki, Hidefumi; Miyake, Masao; O-ishi, Hirotaka; Katahira, Kiyoaki; Nagayama, Tadanori; Miyamoto, Yukako; Hasegawa, Masamitsu; Wago, Haruyuki; Okouchi, Toshiyasu; Shimizu, Tsuyoshi

    2014-01-01

    We investigated effect of microgravity environment during spaceflight on postnatal development of the rheological properties of the aorta in rats. The neonate rats were randomly divided at 7 days of age into the spaceflight, asynchronous ground control, and vivarium control groups (8 pups for one dam). The spaceflight group rats at 9 days of age were exposed to microgravity environment for 16 days. A longitudinal wall strip of the proximal descending thoracic aorta was subjected to stress-strain and stress-relaxation tests. Wall tensile force was significantly smaller in the spaceflight group than in the two control groups, whereas there were no significant differences in wall stress or incremental elastic modulus at each strain among the three groups. Wall thickness and number of smooth muscle fibers were significantly smaller in the spaceflight group than in the two control groups, but there were no significant differences in amounts of either the elastin or collagen fibers among the three groups. The decreased thickness was mainly caused by the decreased number of smooth muscle cells. Plastic deformation was observed only in the spaceflight group in the stress-strain test. A microgravity environment during spaceflight could affect postnatal development of the morphological and rheological properties of the aorta. PMID:25210713

  12. Factors Affecting Software Cost Estimation in Developing Countries

    Directory of Open Access Journals (Sweden)

    Ali Javed

    2013-04-01

    Full Text Available Cost is the main driving factor for all projects. When it is done correctly, it helps in the successful completion of the project. In this research we have discussed various factors that affect the estimation procedure. These include team structure, team culture, managerial style, project type (Core application or integrated application, client’s working environment. Accurate estimation is far difficult in developing countries where most of the organizations follow local standards. These inaccurate estimations lead to late delivery, less profit or in worst case complete failure. Software requirement gathering, development, maintenance, quality assurance and cost of poor quality are major groups responsible for overall cost in software production process. The exact proportion among them varies significantly in consecutive software releases, which is caused by many factors. The ever increasing need for the reliability of the software systems, especially mission critical applications in the public safety domain, raises the bar for the accuracy of prediction and estimation techniques. The accuracy of estimations in many areas brings about more concerns regarding techniques already used in the software industry. Widely deployed techniques, such as Wideband Delphi method, stress the engineering and technical aspects of the process of how estimates are prepared.

  13. Does petroleum development affect burrowing owl nocturnal space-use?

    Energy Technology Data Exchange (ETDEWEB)

    Scobie, Corey; Wellicome, Troy; Bayne, Erin [Department of Biological Sciences, University of Alberta (Canada)], email: cscobie@ualberta.ca, email: tiw@ualberta.ca, email: bayne@ualberta.ca

    2011-07-01

    Decline all over Canada in the population of burrowing owls, a federally listed endangered species, has raised concerns about the possible influence of petroleum infrastructure development on owl nocturnal space-use while foraging. Roads, wells, pipelines and sound-producing facilities related to petroleum development change the landscape and can influence the owls' mortality risk. For 3 years, 27 breeding adult male burrowing owls with nests close to different petroleum infrastructures were captured and fitted with a miniature GPS datalogger in order to track their nocturnal foraging. Data from these GPS devices were fed into a geographical information system and showed that pipelines and wells did not alter the foraging habits of the owls. Dirt and gravel roads, with little traffic, were preferentially selected by the owls, conceivably because of higher owl mortality risk along paved roads. Sound-producing facilities did not change owls' foraging behaviour, implying that sound may not affect their nocturnal space-use. Traffic data and sound power measurements will be used in further studies in an effort to better understand burrowing owls' nocturnal foraging habits.

  14. Dynamic CCT Diagram of Automobile Beam Steel With High Strength Produced by FTSR Technology

    Institute of Scientific and Technical Information of China (English)

    WANG Xin; KANG Yong-lin; YU Hao; CHEN Li-bin; KONG Qing-fu

    2008-01-01

    The dynamic continuous cooling transformation (CCT) diagram and phase transformation rules of 510 MPa automobile beam steel, which is produced by a continuous casting of thin slab of FTSR technology in Tangshan Iron and Steel Co. Ltd. , are researched by thermal simulation experiment. The mierostructure characteristics of the beam steel under different test conditions are studied by means of optical microscope and scanning electron microscope. The test results show that the critical temperatures of phase transformation Ar3 and Ar1 will all decrease with the increase of the cooling rate. When the cooling rate is lower than 20℃·s-1, the ferrite and pearlite phase transformations are the main parts; when the cooling rate is higher than 20℃· s-1, the bainite phase appears. Moreover, the microstructurea of 510 MPa automobile beam steel produced by FTSR technology are also studied, and the results are basically in accordance with the CCT diagram gained from the test.

  15. Continuous cooling transformation(CCT) curve of a novel Al-Cu-Li alloy

    Institute of Scientific and Technical Information of China (English)

    LI Hong-ying; GENG Jin-feng; ZHENG Zi-qiao; WANG Chang-jian; SU Yao; HU Bin

    2006-01-01

    An effective method of measuring continuous cooling transformation(CCT) curve is studied. Corresponding to different cooling rate range, the different measurement methods are employed. The phase-transformation temperatures at slow cooling rate are determined by differential thermal analysis(DTA). The phase-transformation temperatures at medium cooling rate are obtained by measuring a ratio of resistance change against temperature. The phase-transformation temperatures at high cooling rate are measured with thermal mechanical simulator and X-ray diffractometer. Mechanical property combined with microstructure of the samples at various cooling rates is studied and the CCT curve of the alloy is constructed. When the cooling rate increases, phase- transformation temperature drops and the quantity of the secondary phase decreases. The solid solution strengthening is the leading strengthening mechanism during the quench and the hardness increases with the increase of the cooling rate.

  16. Reflections on the EU CCT Application to Import of Goods in Romania

    OpenAIRE

    2009-01-01

    In terms of customs policy for Romania EU accession requires the elimination of customs duties on all imports from countries and overall customs duties reduction on imports from third countries. By implementation the Common Customs Tariff (CCT) duties of Romania have seen a change in the value but at the same time, a change in the tariff regime applied on trading partners. Therefore, the utilization of the EU Common Customs Tariff is a very important opening of the Romanian market which will ...

  17. Large-scale mapping of mutations affecting zebrafish development

    Directory of Open Access Journals (Sweden)

    Neuhauss Stephan C

    2007-01-01

    Full Text Available Abstract Background Large-scale mutagenesis screens in the zebrafish employing the mutagen ENU have isolated several hundred mutant loci that represent putative developmental control genes. In order to realize the potential of such screens, systematic genetic mapping of the mutations is necessary. Here we report on a large-scale effort to map the mutations generated in mutagenesis screening at the Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers. Results We have selected a set of microsatellite markers and developed methods and scoring criteria suitable for efficient, high-throughput genome scanning. We have used these methods to successfully obtain a rough map position for 319 mutant loci from the Tübingen I mutagenesis screen and subsequent screening of the mutant collection. For 277 of these the corresponding gene is not yet identified. Mapping was successful for 80 % of the tested loci. By comparing 21 mutation and gene positions of cloned mutations we have validated the correctness of our linkage group assignments and estimated the standard error of our map positions to be approximately 6 cM. Conclusion By obtaining rough map positions for over 300 zebrafish loci with developmental phenotypes, we have generated a dataset that will be useful not only for cloning of the affected genes, but also to suggest allelism of mutations with similar phenotypes that will be identified in future screens. Furthermore this work validates the usefulness of our methodology for rapid, systematic and inexpensive microsatellite mapping of zebrafish mutations.

  18. Whole transcriptome data analysis of zebrafish mutants affecting muscle development.

    Science.gov (United States)

    Armant, Olivier; Gourain, Victor; Etard, Christelle; Strähle, Uwe

    2016-09-01

    Formation of the contractile myofibril of the skeletal muscle is a complex process which when perturbed leads to muscular dystrophy. Herein, we provide a mRNAseq dataset on three different zebrafish mutants affecting muscle organization during embryogenesis. These comprise the myosin folding chaperone unc45b (unc45b-/-), heat shock protein 90aa1.1 (hsp90aa1.1-/-) and the acetylcholine esterase (ache-/-) gene. The transcriptome analysis was performed in duplicate experiments at 72 h post-fertilization (hpf) for all three mutants, with two additional times of development (24 hpf and 48 hpf) for unc45b-/-. A total of 20 samples were analyzed by hierarchical clustering for differential gene expression. The data from this study support the observation made in Etard et al. (2015) [1] (http://dx.doi.org/10.1186/s13059-015-0825-8) that a failure to fold myosin activates a unique transcriptional program in the skeletal muscles that is different from that induced in stressed muscle cells. PMID:27274534

  19. Neonatal handling affects durably bonding and social development.

    Directory of Open Access Journals (Sweden)

    Séverine Henry

    Full Text Available The neonatal period in humans and in most mammals is characterized by intense mother-young interactions favoring pair bonding and the adaptation of neonates to their new environment. However, in many post-delivery procedures, human babies commonly experience combined maternal separation and intense handling for about one hour post-birth. Currently, the effects of such disturbances on later attachment and on the development of newborns are still debated: clearly, further investigations are required. As animals present good models for controlled experimentation, we chose domestic horses to investigate this issue. Horses, like humans, are characterized by single births, long lactating periods and selective mother-infant bonds. Routine postnatal procedures for foals, as for human babies, also involve intense handling and maternal separation. In the present study, we monitored the behavior of foals from early stages of development to "adolescence", in a normal ecological context (social groups with adults and peers. Experimental foals, separated from their mothers and handled for only 1 hour post-birth, were compared to control foals, left undisturbed after birth. Our results revealed short- and long-term effects of this unique neonatal experience on attachment and subsequent social competences. Thus, experimental foals presented patterns of insecure attachment to their mothers (strong dependence on their mothers, little play and impaired social competences (social withdrawal, aggressiveness at all ages. We discuss these results in terms of mother-young interactions, timing of interactions and relationships between bonding and subsequent social competences. Our results indicate that this ungulate species could become an interesting animal model. To our knowledge, this is the first clear demonstration that intervention just after birth affects bonding and subsequent social competences (at least until "adolescence". It opens new research directions for

  20. Socio–affective development in primary teachers’ initial training

    Directory of Open Access Journals (Sweden)

    María Pilar Teruel Melero

    2009-04-01

    Full Text Available This article begins by analysing the importance of socio-affective education at school, considering that it should be framed within ethics. It then analyses why it is important to train primary teachers in emotional education, advocating that it should be articulated around two basic standpoints: theoretical training and personal, experienced training, highlighting that the second one is crucial in order for primary teachers to emotionally educate their pupils. The article further focuses on the main socio-affective competences the primary teacher should have to face the challenges of education in such an unsettled and complex world as ours, positioning ourselves in favour of a socio-affective, experienced and active methodology. Finally, we provide an overview of emotional education in the Spanish school system and in primary teacher initial training curricula.

  1. Maternal Stress and Affect Influence Fetal Neurobehavioral Development.

    Science.gov (United States)

    DiPietro, Janet A.; Hilton, Sterling C.; Hawkins, Melissa; Costigan, Kathleen A.; Pressman, Eva K.

    2002-01-01

    Investigated associations between maternal psychological and fetal neurobehavioral functioning with data provided at 24, 30, and 36 weeks gestation. Found that fetuses of women who were more affectively intense, appraised their lives as more stressful, and reported more pregnancy-specific hassles were more active across gestation. Fetuses of women…

  2. How the macroeconomic environment affects human resource development

    OpenAIRE

    Van Adams, Arvil; Goldfarb, Robert; Kelly, Terence

    1992-01-01

    Do inward-focused development strategies reduce competition in factor markets and incentives for more efficient skills development? Do outward-focused development strategies improve them? The authors compared vocational education and training systems in six developing countries in the 1980s. They found that an outward orientation encourages more efficient development of human resources. Protectionist trade regimes that shelter producers from global competition produce price distortions in dom...

  3. Application of CCT Technique to Simulate Vibrational Spectra of Nucleic Acid Oligomers

    Czech Academy of Sciences Publication Activity Database

    Andrushchenko, Valery; Bouř, Petr

    Lviv : -, 2011. s. 41-41. [Methods and Applications of Computational Chemistry. International Symposium /4./. 28.06.2011-02.07.2011, Lviv] R&D Projects: GA ČR GAP208/10/0559; GA ČR GAP208/11/0105 Grant ostatní: AV ČR(CZ) M200550902 Institutional research plan: CEZ:AV0Z40550506 Keywords : IR spectroscopy * VCD spectroscopy * quantum chemistry spectra simulations * Cartesian coordinate transfer (CCT) * nucleic acids Subject RIV: CF - Physical ; Theoretical Chemistry

  4. Potential for thermal coal and Clean Coal Technology (CCT) in the Asia-Pacific. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, C.J.; Long, S.

    1991-11-22

    The Coal Project was able to make considerable progress in understanding the evolving energy situation in Asia and the future role of coal and Clean Coal Technologies. It is clear that there will be major growth in consumption of coal in Asia over the next two decades -- we estimate an increase of 1.2 billion metric tons. Second, all governments are concerned about the environmental impacts of increased coal use, however enforcement of regulations appears to be quite variable among Asian countries. There is general caution of the part of Asian utilities with respect to the introduction of CCT`s. However, there appears to be potential for introduction of CCT`s in a few countries by the turn of the century. It is important to emphasize that it will be a long term effort to succeed in getting CCT`s introduced to Asia. The Coal Project recommends that the US CCT program be expanded to allow the early introduction of CCT`s in a number of countries.

  5. Developing Sensor Augmented Objects for Self-report of Affect

    OpenAIRE

    Liang, Yuxiang

    2012-01-01

    In recent years, more and more people have realized that emotion can affect their daily life in a certain extent. However, it is not easy to measure the emotion in a precise way. In this paper, we aim to extend the Sensual Evaluation Instrument to improve the self-report quality of emotion. The purpose of this instrument is to obtain as much information as possible about people’s emotion, which contributes to make self-report more precisely. It will be used to detect participants' emotion inf...

  6. Policies and regulations affecting biofuel development in Kenya

    Energy Technology Data Exchange (ETDEWEB)

    Mouk, Benard O.; Kirui, Shadrack; Theuri, Daniel; Wakhungu, Judi W.

    2008-12-15

    An assessment of government initiatives to encourage biofuel development finds the industry is hampered by a lack of policy frameworks. The policy brief looks at the status and possibilities for the various initiatives.

  7. Biomethane: Status and Factors Affecting Market Development and Trade

    OpenAIRE

    Thrän, Daniela; Persson, Tobias; Daniel-Gromke, Jaqueline; PONITKA Jens; Seiffert, Michael; Baldwin, John; Kranzl, Lukas; SCHIPFER Fabian; MATZENBERGER Julian; Devriendt, Nathalie; Dumont, Mathieu; Dahl, Jonas; BOCHMANN Günther

    2014-01-01

    This publication focusses on the status of biomethane (which includes upgraded biogas and bio-SNG) production, grid injection and use in different IEA countries. It also illustrates the options and needs for the development of biomethane supply strategies with the focus of improved trade. Further an overview of expected future development of the biomethane sector is given. As part of of the study, results from a dedicated questionnaire were assessed to get an insight into the opportunities an...

  8. DOES FOREIGN AID AFFECT THE ENVIRONMENT IN DEVELOPING ECONOMIES?

    OpenAIRE

    B Mak Arvin; Parviz Dabir-Alai; Byron Lew

    2006-01-01

    Preserving the environment is important from both national and international perspectives. Similarly, the provision of foreign assistance from richer to poorer nations is often seen as an imperative. However, there is a noticeable gap in research on how aid flows are linked to the environment in developing economies. Using the method of Granger causality, this paper explores the possible linkages. Results indicate that the external debt of a developing country bears upon the relationship in i...

  9. Factors Affecting Outsourcing Software Development from Finland to Vietnam

    OpenAIRE

    Le, Phuong

    2016-01-01

    The past few years have seen a steady trend in the growth of Offshore Outsourcing Soft-ware Development projects from Finland. At the same time, Vietnam has been quickly growing as a competitive outsourcing destination. Many outsourcing vendors from Vietnam want to enter Finnish software development market through contracts of outsourcing projects. They have neither had a competitive edge of international business relation nor a deep understanding of the Finnish market. The objectives of the ...

  10. A novel family of small proteins that affect plant development

    Energy Technology Data Exchange (ETDEWEB)

    John Charles Walker

    2011-04-29

    The DVL genes represent a new group of plant proteins that influence plant growth and development. Overexpression of DVL1, and other members of the DVL family, causes striking phenotypic changes. The DVL proteins share sequence homology in their C-terminal half. Point mutations in the C-terminal domain show it is necessary and deletion studies demonstrate the C-terminal domain is sufficient to confer the overexpression phenotypes. The phenotypes observed, and the conservation of the protein sequence in the plant kingdom, does suggest the DVL proteins have a role in modulating plant growth and development. Our working hypothesis is the DVL proteins function as regulators of cellular signaling pathways that control growth and development.

  11. Early Social Experience Affects the Development of Eye Gaze Processing.

    Science.gov (United States)

    Senju, Atsushi; Vernetti, Angélina; Ganea, Natasa; Hudry, Kristelle; Tucker, Leslie; Charman, Tony; Johnson, Mark H

    2015-12-01

    Eye gaze is a key channel of non-verbal communication in humans. Eye contact with others is present from birth, and eye gaze processing is crucial for social learning and adult-infant communication. However, little is known about the effect of selectively different experience of eye contact and gaze communication on early social and communicative development. To directly address this question, we assessed 14 sighted infants of blind parents (SIBPs) longitudinally at 6-10 and 12-16 months. Face scanning and gaze following were assessed using eye tracking. In addition, naturalistic observations were made when the infants were interacting with their blind parent and with an unfamiliar sighted adult. Established measures of emergent autistic-like behaviors and standardized tests of cognitive, motor, and linguistic development were also collected. These data were then compared with those obtained from a group of infants of sighted parents. Despite showing typical social skills development overall, infants of blind parents allocated less attention to adult eye movements and gaze direction, an effect that increased between 6-10 and 12-16 months of age. The results suggest that infants adjust their use of adults' eye gaze depending on gaze communication experience from early in life. The results highlight that human functional brain development shows selective experience-dependent plasticity adaptive to the individual's specific social environment. PMID:26752077

  12. Do urbanization and industrialization affect energy intensity in developing countries?

    International Nuclear Information System (INIS)

    Against a backdrop of concerns about climate change, peak oil, and energy security issues, reducing energy intensity is often advocated as a way to at least partially mitigate these impacts. This study uses recently developed heterogeneous panel regression techniques like mean group estimators and common correlated effects estimators to model the impact that income, urbanization and industrialization has on energy intensity for a panel of 76 developing countries. In the long-run, a 1% increase in income reduces energy intensity by − 0.45% to − 0.35%. Long-run industrialization elasticities are in the range 0.07 to 0.12. The impact of urbanization on energy intensity is mixed. In specifications where the estimated coefficient on urbanization is statistically significant, it is slightly larger than unity. The implications of these results for energy policy are discussed. - Highlights: ► The impact of urbanization and industrialization on energy intensity is modeled. ► Use recently developed heterogeneous panel regression techniques ► The model is tested on a panel of developing countries. ► Income has a negative impact on energy intensity. ► Industrialization has a positive impact on energy intensity

  13. Developing Culturally Competent Faculty: A Cognitive, Affective, and Spiritual Model

    Science.gov (United States)

    Taylor, Deborah L.; Van Zandt, Cassandra; Menjares, Pete C.

    2013-01-01

    The past decade has evidenced significant dialogue on faith-based campuses about the persistent gap between the increasing ethnic diversity of the student population and that of the faculty. While campus administrators and leaders acknowledge the need to address this concern through faculty development, there is a disturbing lack of successful…

  14. Traumatic Experience in Infancy: How Responses to Stress Affect Development

    Science.gov (United States)

    Witten, Molly Romer

    2010-01-01

    Responses to traumatic stress during the earliest years of life can change quickly and can be difficult to identify because of the young child's rapid rate of development. The symptoms of traumatic stress will depend on the child's developmental level and individual coping styles, as well as the quality and nature of the child's most important…

  15. Dietary-induced hyperthyroidism marginally affects neonatal testicular development

    NARCIS (Netherlands)

    Rijntjes, E.; Wientjes, A.T.; Swarts, H.J.; Rooij, de D.G.; Teerds, K.J.

    2008-01-01

    The objective of this study was to determine whether dietary-induced mild fetal/neonatal hyperthyroidism influenced the initiation of spermatogenesis and the development of the adult-type Leydig cell population. Previously, the effects of neonatally induced hyperthyroidism have been investigated in

  16. The maize rachis affects Aspergillus flavus movement during ear development

    Science.gov (United States)

    Aspergillus flavus expressing green fluorescent protein (GFP) was used to follow infection in ears of maize hybrids resistant and susceptible to the fungus. Developing ears were needle-inoculated with GFP-transformed A. flavus 20 days after silk emergence, and GFP fluorescence in the pith was evalu...

  17. Starting Smart: How Early Experiences Affect Brain Development. Second Edition.

    Science.gov (United States)

    Hawley, Theresa

    Based on recent research, it is now believed that brain growth is highly dependent upon children's early experiences. Neurons allow communication and coordinated functioning among various brain areas. Brain development after birth consists of an ongoing process of wiring and rewiring the connections among neurons. The forming and breaking of…

  18. Maternal seizures can affect the brain developing of offspring.

    Science.gov (United States)

    Cossa, Ana Carolina; Lima, Daiana Correia; do Vale, Tiago Gurgel; de Alencar Rocha, Anna Karynna Alves; da Graça Naffah-Mazzacoratti, Maria; da Silva Fernandes, Maria José; Amado, Debora

    2016-08-01

    To elucidate the impact of maternal seizures in the developing rat brain, pregnant Wistar rats were subjected to the pilocarpine-induced seizures and pups from different litters were studied at different ages. In the first 24 h of life, blood glucose and blood gases were analyzed. (14)C-leucine [(14)C-Leu] incorporation was used to analyze protein synthesis at PN1, and Western Blot method was used to analyze protein levels of Bax, Bcl-2 and Poly(ADP-ribose) polymerase-1 (PARP-1) in the hippocampus (PN3-PN21). During the first 22 days of postnatal life, body weight gain, length, skull measures, tooth eruption, eye opening and righting reflex have been assessed. Pups from naive mothers were used as controls. Experimental pups showed a compensated metabolic acidosis and hyperglycemia. At PN1, the [(14)C-Leu] incorporation into different studied areas of experimental pups was lower than in the control pups. During development, the protein levels of Bax, Bcl-2 and PARP-1 in the hippocampus of experimental pups were altered when compared with control pups. A decreased level of pro- and anti-apoptotic proteins was verified in the early postnatal age (PN3), and an increased level of pro-apoptotic proteins concomitant with a reduced level of anti-apoptotic protein was observed at the later stages of the development (PN21). Experimental pups had a delay in postnatal growth and development beyond disturb in protein synthesis and some protein expression during development. These changes can be result from hormonal alterations linked to stress and/or hypoxic events caused by maternal epileptic seizures during pregnancy. PMID:27085526

  19. Does Perceived Support in Employee Development Affect Personnel Turnover?

    OpenAIRE

    Koster Fleur; Grip Andries de; Fouarge Didier

    2009-01-01

    This paper focuses on the question whether it is beneficial for firms to invest in the general skills of their workforce or that these training investments merely encourage personnel turnover. We examine two contrary theoretical perspectives on how investments in employee development are related to their turnover behaviour. Estimation results derived from a sample of 2,833 Dutch pharmacy assistants show that participation in general training does not induce the intention of assistants to quit...

  20. EmotionsOnto: an ontology for developing affective applications

    OpenAIRE

    López Gil, Juan Miguel; García González, Roberto; Gil Iranzo, Rosa María; Collazos Ordóñez, César A.

    2014-01-01

    EmotionsOnto is a generic ontology for describing emotions and their detection and expression systems taking contextual and multimodal elements into account. The ontology is proposed as a way to develop an easily computerizable and flexible formal model. Moreover, it is based on the Web Ontology Language (OWL) standard, which also makes ontologies easily shareable and extensible. Once formalized as an ontology, the knowledge about emotions can be used in order to make computers more personali...

  1. Oligosaccharides Affect Performance and Gut Development of Broiler Chickens

    OpenAIRE

    Ao, Z; Choct, M.

    2013-01-01

    The effects of oligosaccharide supplementation on the growth performance, flock uniformity and GIT development of broiler chickens were investigated. Four diets, one negative control, one positive control supplemented with zinc-bacitracin, and two test diets supplemented with mannoligosaccharide (MOS) and fructooligosaccharide (FOS), were used for the experiment. Birds given MOS or FOS had improved body weight (BW) and feed efficiency (FCR), compared to those fed the negative control diet dur...

  2. A Content Analysis of Factors Affecting New Product Development Process

    OpenAIRE

    Eda Atilgan-Inan; Aslihan Buyukkupcu; Serkan Akinci

    2010-01-01

    The objective of this study is to review the international marketing literature on new product development process and compare the changes in the important factors in the process with the changes in the management approaches. For this purpose, the articles in three international marketing journals were selected and “new product development” and “new product performance” were searched for in the abstracts. After grouping the variables in the process, they were compared with the perspectives of...

  3. Legislative framework affecting First Nations and resource development

    International Nuclear Information System (INIS)

    In its Delgamuukw decision (released December 1997), the Supreme Court of Canada has given a clear direction to the Crown and First Nations to negotiate rather than litigate outstanding claims within the province of British Columbia. This paper describes the practical implications which the Delgamuukw decision will have for resource development on lands located within the traditional territories of Aboriginal people, reviews constitutional and jurisdictional issues, and discusses issues such as reserve lands in British Columbia, including the nature of reserve interest, tax considerations, the surrender of reserve lands, and provincial regulation on reserve lands

  4. Organizational development in Ethiopia: Factors affecting organizations’ implementation of feedback

    Directory of Open Access Journals (Sweden)

    Ariel Falconer

    2014-05-01

    Full Text Available Non-governmental organizations (NGOs receiving organizational development assistance funded and facilitated by a third party frequently receive recommendations designed to improve their overall functioning. Research suggests that tailored in-person communication of recommendations results in increased implementation of recommendations. This study assessed whether the method and frequency of communication from an outside organization influenced Ethiopian NGOs’ ability to implement organizational development recommendations. A secondary study goal was to identify additional factors that facilitated or inhibited implementation of recommendations. Twenty two NGOs were surveyed about the amount, type, and timing of communication; their perception of the value of communication in implementing recommendations; barriers to implementation; and strategies used to overcome barriers to implementation. The frequency and level of personalization of communication was not consistently associated with organizational implementation of recommendations. Receiving communication was significantly associated with an organization’s motivation (mean = 4.5 ± 0.6, understanding (mean = 4.2 ± 0.6, and ability (mean = 3.9 ± 0.6 to implement recommendations (p value = 0.02. Respondents reported that external factors, including funding; staff time, expertise, and training; information systems; leadership; and government regulations on nonprofit administrative spending, strongly influenced their ability to implement recommendations.

  5. A Content Analysis of Factors Affecting New Product Development Process

    Directory of Open Access Journals (Sweden)

    Eda Atilgan-Inan

    2010-07-01

    Full Text Available The objective of this study is to review the international marketing literature on new product development process and compare the changes in the important factors in the process with the changes in the management approaches. For this purpose, the articles in three international marketing journals were selected and “new product development” and “new product performance” were searched for in the abstracts. After grouping the variables in the process, they were compared with the perspectives of management in the related periods. The results indicated that organizational factors have always been important for new product development process, which is in line with the nature of the innovation process. But the emphasis on internal factors has increased in the 21st century which is congruent with the change in management perspective foregrounding resource based view. The study differs from the similar literature review studies on the point that it deals with the topic from international marketing perspective. Therefore, R&D and other marketing studies are not included in the review and the study proposes the important factors from international firms’ point of view.

  6. Does Vitamin C Deficiency Affect Cognitive Development and Function?

    Directory of Open Access Journals (Sweden)

    Stine Normann Hansen

    2014-09-01

    Full Text Available Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/− mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.

  7. Cabbage-head development as affected by nitrogen and temperature

    International Nuclear Information System (INIS)

    Cabbage plants were grown at graded levels of nitrate nitrogen (20 and 100 ppm N) and temperature (15, 20, and 250C, and the effects of these treatments on cabbage-head development were investigated. The total plant dry weight and the cabbage-head yield were always higher at 100 ppm N than at 20 ppm N, and at each N level the values were in the order of 20>15>250C. The nitrogen content in the outer leaves was higher at 100 ppm N than at 20 ppm N, and increased slightly with increase in temperature. The total sugar content was higher in the inner head leaves than in the outer leaves, and was decreased greatly at 250C in both organs. The 14CO2 assimilation of the outer leaves was larger at 100 ppm N than at 20 ppm N. After 14CO2 assimilation by the plants, a greater amount of 14C was lost by respiration at 250C than at 15 and 200C, resulting in a low distribution of 14C-sugars in the inner head leaves. The highest yield and a better quality of cabbage-heads were obtained when the plants were grown at 200C with a high N supply and the outer leaves had a carbohydrate/nitrogen content ratio of about 7. (author)

  8. The CCT diagrams of ultra low carbon bainitic steels and their impact toughness properties

    International Nuclear Information System (INIS)

    The CCT diagrams of ULCBNi steels, HN3MV, HN3MVCu having 5.1% Ni and 3.5% Ni and Cu bearing steels; HN3M1.5Cu, HSLA 100 have been determined. The reduced carbon concentration in steel, in order to prevent the formation of cementite, allowed for using nickel, manganese, chromium and molybdenum to enhance hardenability and refinement of the bainitic microstructures by lowering BS temperature. Copper and microadditions of vanadium and niobium are successfully used for precipitation strengthening of steel both in thermomechanically or heat treated conditions. Very good fracture toughness at low temperatures and high yield strength properties of HN3MVCu and HN3MV steels allowed for fulfillment of the requirements for steel plates for pressure vessels and cryogenic applications. (author)

  9. Progress report for the CCT-WG5 high temperature fixed point research plan

    International Nuclear Information System (INIS)

    An overview of the progress in High Temperature Fixed Point (HTFP) research conducted under the auspices of the CCT-WG5 research plan is reported. In brief highlights are: Provisional long term stability of HTFPs has been demonstrated. Optimum construction methods for HTFPs have been established and high quality HTFPs of Co-C, Pt-C and Re-C have been constructed for thermodynamic temperature assignment. The major sources of uncertainty in the assignment of thermodynamic temperature have been identified and quantified. The status of absolute radiometric temperature measurement has been quantified through the circulation of a set of HTFPs. The measurement campaign to assign low uncertainty thermodynamic temperatures to a selected set of HTFPs will begin in mid-2012. It is envisaged that this will be complete by 2015 leading to HTFPs becoming routine reference standards for radiometry and high temperature metrology

  10. Evaluation of emulsifier stability of biosurfactant produced by Saccharomyces lipolytica CCT-0913

    Directory of Open Access Journals (Sweden)

    Álvaro Silva Lima

    2009-04-01

    Full Text Available Surface-active compounds of biological origin are widely used for many industries (cosmetic, food, petrochemical. The Saccharomyces lipolytica CCT-0913 was able to grow and produce a biosurfactant on 5% (v/v diesel-oil at pH 5.0 and 32ºC. The cell-free broth emulsified and stabilized the oil-in-water emulsion through a first order kinetics. The results showed that the initial pH value and temperature influenced the emulsifier stability (ES, which was the time when oil was separated. The biosurfactant presented different stabilization properties for vegetable and mineral oil in water solution, despite the highest values of the ES occurring with vegetable oil. The biosurfactant presented smallest ES when compared to commercial surfactants; however, this biosurfactant was not purified.Os tensoativos de origem biológica são amplamente utilizados em diversas aplicações. O microrganismo Saccharomyces lipolytica CCT-0913 possui a habilidade de crescer em 5% (v/v óleo diesel a pH 5,0 e 32ºC e produzir biosurfactante. O caldo fermentado livre de células e produzido por S. lipolytica emulsiona e estabiliza emulsões óleo em água de acordo com uma cinética de primeira ordem. Os resultados mostram que o valor do pH inicial e a temperatura influenciam a estabilidade emulsificante (ES, que é medido pelo tempo que a quantidade de óleo. O biosurfactante apresenta diferentes valores de estabilidade emulsificante para óleos vegetais e minerais em emulsões óleo-água, os maiores valores de ES ocorrem nas emulsões utilizando óleo vegetal. O biosurfactante apresenta valores baixos de ES quando comparado com emulsificantes comerciais, entretanto sem sofrer nenhum processo de purificação.

  11. Paracellular pathway of rabbit cortical collecting tubule (CCT): a high resistance, non-selective barrier

    International Nuclear Information System (INIS)

    Previous studies have suggested that the paracellular pathway of CCT is Cl selective. We reassessed this issue under conditions in which the cellular Na and K conductive pathways were blocked by lumen amiloride (50 μM) and Ba++ (4 mM). The residual transepithelial conductance (G/sub T/, 1.10 +- 0.09 mS cm-2) is a reasonable estimate of the paracellular conductance. Three independent assessments of the barrier selectivity were used. First, the effect of symmetrical replacement of Na (TMA, bis (2-hydroxy ethyl) dimethylammonium) or Cl (NO3, gluconate) on G/sub T/ was determined. All test solutions decreased G/sub T/, and in each case the decrease could be accounted for by the lower conductivity of the test solution relative to NaCl. Thus, the pathway does not select one cation or one anion over another. Second, lumen-to-bath 22Na and 36Cl fluxes were measured with 0 Cl/0 HCO3 bath to eliminate cellular Cl flux. The ratio J/sub Na/J/sub Cl/ (0.75 +- 0.14) was not different from the ratio of Na/Cl mobilities in water (0.65), and the sum of the calculated partial ionic conductances of Na and Cl adequately approximated the measured G/sub T/. Third, NaCl concentration was sequentially lowered in lumen or bath. In the presence of bath ouabain, P/sub Na//P/sub Cl/, calculated from dilution voltages was 0.67 +- .02. The paracellular pathway of CCT is non-selective for anions over cations

  12. Integrated gasification combined-cycle research development and demonstration activities in the U.S.

    Energy Technology Data Exchange (ETDEWEB)

    Ness, H.M.

    1994-12-31

    The United States Department of Energy (DOE) has selected seven integrated gasification combined-cycle (IGCC) advanced power systems for demonstration in the Clean Coal Technology (CCT) Program. DOE`s Office of Fossil Energy, Morgantown Energy Technology Center, is managing a research development and demonstration (RD&D)program that supports the CCT program, and addresses long-term improvements in support of IGCC technology. This overview briefly describes the CCT projects and the supporting RD&D activities.

  13. Affective commitment to the employer brand: development and validation of a scale

    OpenAIRE

    Fernandez Lores, Susana; Gavilánn Bouzas, Diana; Avello Iturriagagoitia, María; Blaso López, Francis

    2016-01-01

    In recent years employer branding has become increasingly important as a source of sustainable competitive advantage. Companies are trying to engender affective commitment in the best employees in a global labor market. We develop and validate a multidimensional scale to measure the strength of an employee´s affective commitment to the employer brand in five separate studies. In Study 1 and 2 the Affective Commitment to the Employer Brand (ACEB) scale was developed and tested for its factor s...

  14. The situational factors that affect the software development process: Towards a comprehensive reference framework

    OpenAIRE

    Clarke, Paul; O'Connor, Rory

    2012-01-01

    Context An optimal software development process is regarded as being dependent on the situational characteristics of individual software development settings. Such characteristics include the nature of the application(s) under development, team size, requirements volatility and personnel experience. However, no comprehensive reference framework of the situational factors affecting the software development process is presently available. Objective The absence of such a comprehensive r...

  15. The Development and Application of Affective Assessment in an Upper-Level Cell Biology Course

    Science.gov (United States)

    Kitchen, Elizabeth; Reeve, Suzanne; Bell, John D.; Sudweeks, Richard R.; Bradshaw, William S.

    2007-01-01

    This study exemplifies how faculty members can develop instruments to assess affective responses of students to the specific features of the courses they teach. Means for assessing three types of affective responses are demonstrated: (a) student attitudes towards courses with differing instructional objectives and methodologies, (b) student…

  16. Preparation and characterization of vanadia-titania mixed oxide for immobilization of Serratia rubidaea CCT 5732 and Klebsiella marcescens bacteria

    International Nuclear Information System (INIS)

    Vanadia-titania mixed oxide was synthesized by sol-gel method and characterized by several techniques. Texturally, it is formed by mesopores and presents high-specific surface area and controlled porosity. Scanning electron microscopy revealed that vanadium is homogeneously distributed in the material. Structurally, it was possible to identify characteristic V=O stretching bands by IR. The analysis of X-ray diffraction showed that the material, particularly vanadium, is highly dispersed. Application experiments were carried out through the immobilization of Serratia rubidae CCT 5732 and Klebsiella marcescens bacteria by adsorption on the surface of mixed oxide. The micrographies revealed that the bacteria were adsorbed on the entire support, with average surface densities of 8.55 x 1011 cells/m2 (Serratia rubidae CCT 5732) and 3.40 x 1011 cells/m2 (K. marcescens)

  17. An oligodeoxynucleotide with CCT repeats restrains CpG ODN-induced TLR9 trafficking.

    Science.gov (United States)

    Zhang, Xiaoling; Sun, Wei; Wu, Xiuli; Wang, Hua; Yan, Youyou; Guo, Sheng; Song, Dandan; Li, Hainan; Gao, Shuang; Wang, Luowei; Yu, Yongli; Wang, Liying

    2014-01-01

    Toll-like receptor 9 (TLR9) can sense pathogen DNA and CpG ODN or even self-DNA by trafficking assisted by Unc93B1, an endoplasmic reticulum (ER) transmembrane protein, from ER to endolysosomes or cell surface. In previous study, we found that an oligodeoxynucleotide with CCT repeats (SAT05f) could selectively inhibit TLR7/9 activation. However, the mechanism for the inhibitory activity of SAT05f is still unknown. In present research, it was found that SAT05f could inhibit CpG ODN-induced the intracellular trafficking of TLR9 and Unc93B1 with feedback the responses of decreased surface TLR9 and enhanced TLR9 mRNA expression but not influence TLR9 protein level by using human plasmacytoid dendritic cell line CAL-1 cells, suggesting that SAT05f inhibits TLR9 activation by restraining TLR9 trafficking. Since the mitochondrial DNA released from injured tissue can cause systemic inflammatory response syndrome (SIRS), this study may provide valuable data for prevention and treatment of SIRS and rescue severe trauma patients. PMID:25374030

  18. Regression of nodules on cranial computerized tomography (CCT) scans in 4 focal epileptic patients

    International Nuclear Information System (INIS)

    Epilepsy can be defined as a paroxysmal, excessive, neuronal discharge within the brain originating from either cortical or sugcortical regions. The incidence of epilepsy is increasing possibly due to the survival of persons who should have died of brain injuries or other cerebral abnormalities acquired in early life. The use of antibiotics and improvement in the medical care have saved many children who might have died of meningitis, brain abscess, encephalitis, severe head injuries, etc. CCT scan is new radiologic procedure for defining cranial and intracranial structures and also an useful procedure for evaluation and follow-up (FU) of patient with focal seizure disorder. Recently we experienced nodules which were isodense or hypodense on initial non contrasted CT (NECT) and scans became hyperdense of the enhancement in 4 cases of focal epileptic seizure. Nearly complete disappearance or regression of the epileptic foci occurred on the FU CT scans in 2 cases. Operation was performed in 2 cases. The tissue specimen obtained from the CT nodule revealed cerebral edema in one case and localized gliosis and congestion in the other. All the patients showed marked clinical improvement when the CT nodule improved. Review of literature failed to disclose any previous report on such observation

  19. A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

    Science.gov (United States)

    Matsuki, Takahiro; Yahagi, Kana; Mori, Hiroshi; Matsumoto, Hoshitaka; Hara, Taeko; Tajima, Saya; Ogawa, Eishin; Kodama, Hiroko; Yamamoto, Kazuya; Yamada, Takuji; Matsumoto, Satoshi; Kurokawa, Ken

    2016-01-01

    Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affect infant health. Genome analysis of infants' bifidobacteria reveals an ABC transporter as a key genetic factor for FL utilization. Thus, the ability of bifidobacteria to utilize FL and the presence of FL in breast milk may affect the development of the gut microbiota in infants, and might ultimately have therapeutic implications. PMID:27340092

  20. Factors Affecting Teachers' Participation in Continuing Professional Development (CPD): From Hong Kong Primary School Teachers' Perspectives

    Science.gov (United States)

    Wan, Sally Wai-Yan.; Lam, Patrick Hak-Chung

    2010-01-01

    This paper presents the findings from a small-scale case study of Hong Kong primary teachers' perceptions of the factors affecting teachers' participation in continuing professional development (CPD). The study applies a multiple approach with mixed research methods, including using a self-developed survey questionnaire on the basis of the CPD…

  1. The Relationship Between Affective and Cognitive Development in Down's Syndrome Infants.

    Science.gov (United States)

    Cicchetti, Dante; Sroufe, L. Alan

    Examined was the association between affective and cognitive development in 14 Down's Syndrome infants (4- to 8-months-old). Mothers administered a series of 30 laughter items each month, and experimenters gave the Uzgiris-Hunt scales of cognitive development at 13 and 16 months, and the Bayley scales and Infant Behavior Record at 16 months.…

  2. CNTNAP2 variants affect early language development in the general population.

    OpenAIRE

    Whitehouse, AJ; Bishop, DV; Ang, QW; Pennell, CE; Fisher, SE

    2011-01-01

    Early language development is known to be under genetic influence, but the genes affecting normal variation in the general population remain largely elusive. Recent studies of disorder reported that variants of the CNTNAP2 gene are associated both with language deficits in specific language impairment (SLI) and with language delays in autism. We tested the hypothesis that these CNTNAP2 variants affect communicative behavior, measured at 2 years of age in a large epidemiological sample, the We...

  3. Defects in Protein Folding Machinery Affect Cell Wall Integrity and Reduce Ethanol Tolerance in S. cerevisiae.

    Science.gov (United States)

    Narayanan, Aswathy; Pullepu, Dileep; Reddy, Praveen Kumar; Uddin, Wasim; Kabir, M Anaul

    2016-07-01

    The chaperonin complex CCT/TRiC (chaperonin containing TCP-1/TCP-1 ring complex) participates in the folding of many crucial proteins including actin and tubulin in eukaryotes. Mutations in genes encoding its subunits can affect protein folding and in turn, the physiology of the organism. Stress response in Saccharomyces cerevisiae is important in fermentation reactions and operates through overexpression and underexpression of genes, thus altering the protein profile. Defective protein folding machinery can disturb this process. In this study, the response of cct mutants to stress conditions in general and ethanol in specific was investigated. CCT1 mutants showed decreased resistance to different conditions tested including osmotic stress, metal ions, surfactants, reducing and oxidising agents. Cct1-3 mutant with the mutation in the conserved ATP-binding region showed irreversible defects than other mutants. These mutants were found to have inherent cell wall defects and showed decreased ethanol tolerance. This study reveals that cell wall defects and ethanol sensitivity are linked. Genetic and proteomic analyses showed that the yeast genes RPS6A (ribosomal protein), SCL1 (proteasomal subunit) and TDH3 (glyceraldehyde-3-phosphate dehydrogenase) on overexpression, improved the growth of cct1-3 mutant on ethanol. We propose the breakdown of common stress response pathways caused by mutations in CCT complex and the resulting scarcity of functional stress-responsive proteins, affecting the cell's defence against different stress agents in cct mutants. Defective cytoskeleton and perturbed cell wall integrity reduce the ethanol tolerance in the mutants which are rescued by the extragenic suppressors. PMID:26992923

  4. How Do Location Decisions of Firms and Households Affect Economic Development in Rural America?

    OpenAIRE

    Wu, Junjie; Gopinath, Munisamy

    2005-01-01

    This paper examines the causes of spatial inequalities in economic development across rural America. A theoretical model is developed to analyze interactions between location decisions of firms and households as they are affected by natural endowments, accumulated human and physical capital, and economic geography. Based on the theoretical analysis, an empirical model is specified to quantify the effect of these factors on key indicators of economic development across counties in the United S...

  5. Protective role of taurine in developing offspring affected by maternal alcohol consumption

    OpenAIRE

    Ananchaipatana-Auitragoon, Pilant; Ananchaipatana-Auitragoon, Yutthana; Siripornpanich, Vorasith; Kotchabhakdi, Naiphinich

    2015-01-01

    Maternal alcohol consumption is known to affect offspring growth and development, including growth deficits, physical anomalies, impaired brain functions and behavioral disturbances. Taurine, a sulfur-containing amino acid, is essential during development, and continually found to be protective against neurotoxicity and various tissue damages including those from alcohol exposure. However, it is still unknown whether taurine can exert its protection during development of central nervous syste...

  6. Factors Affecting Malnutrition in Developing Countries: A Linear Mixed Model Approach

    OpenAIRE

    Sohair F. Higazi; Dina Hassan Abdel-Hady; Samir A. M. Al-Oulfi

    2012-01-01

     AbstractThe main objective of this study is to pinpoint the main factors that affect the percentage who suffers of malnutrition in developing countries. Three locations are randomly chosen: Asia, Africa, and Middle east and North Africa ( MENA); A total of 96 countries were chosen randomly from 137  developing countries of the three locations; and were cross classified by " Location" and  " Human Development Index (HDI) as high, middle, and low (UNDP,  2005).  Data f...

  7. Systematic Analysis on Factors Affecting the Development of Rural Tourism: A Case Study of Chengdu

    Institute of Scientific and Technical Information of China (English)

    He Jing-ming; Li Hui-xia

    2003-01-01

    Based on field survey, the thesis analyzes the key factors affecting development of rural tourism systematically,taking Chengdu as an example. These factors include regional economic development level & leisure tradition, tourist market &traffic, tourist resource, spatial agglomeration and competition of rural tourism, and decision-making behavior. Among them,regional economic development level & leisure tradition and tourist market & traffic are prerequisites for the development of rural tourism which have an impact on tourist's consumption level,consumption custom, operator's investment ability, tourist destination distribution and scale; Tourist resource, spatial agglomeration and competition of rural tourism are restrictive conditions affecting character and distribution of rural tourism; Government's decision-making behavior is of importance for expansion of scale and popularity of regional rural tourism, meanwhile, operators' decision-making behavior includes investment scale and operational strategies, and for operators from the outside, location selection is included additionally. All these decision-making behaviors are subjective conditions for the development of rural tourism.

  8. Uso de caldo de cana-de-açúcar para produção de levana por Zymomonas mobilis CCT4494 Sugarcane juice use for levan production by zymomonas mobilis CCT4494

    Directory of Open Access Journals (Sweden)

    Fernanda Maria Pagane Guereschi Ernandes

    2011-04-01

    Full Text Available A levana é um exopolissacarídeo constituído por unidades de frutose, unidas pó ligações β(2 → 6, sintetizado por vários microrganismos durante a fermentação de um meio de cultura à base de sacarose, extrato de levedura e sais minerais. Este biopolímero possui diversas aplicações tanto na área de alimentos (fixador de cores e sabores, espessante e estabilizante de vários alimentos como também na farmacêutica (substituto de plasma sanguíneo, imunomodulador, anticarcinogênico e hipocolesterolêmico. Objetivou-se, com este trabalho, realizar um estudo comparativo da produção de levana a partir de Zymomonas mobilis CCT 4494, utilizando os meios de fermentação sintético e o caldo de cana-de-açúcar, por este ser considerado um substrato de baixo custo comercial para o processo fermentativo, devido a sua abundância e facilidade de obtenção no Brasil. Os resultados obtidos indicaram que o caldo de cana-de-açúcar, utilizado como meio de cultura alternativo, é uma matéria-prima adequada para a fermentação por Zymomonas mobilis CCT 4494, pois a sua composição possibilitou a obtenção de rendimentos de levana superiores ou semelhantes às concentrações de sacarose testadas com o meio sintético.Levan is an exopolysaccharide constituted by fructose units, β(2 → 6 linked, synthesized by several microorganisms during fermentation of a culture medium containing sucrose, yeast extract and mineral salts. This biopolymer has various applications as much in food area (colors and flavors fixer, thickener and stabilizer of several foods as in pharmaceutical one (blood plasma replacement, immunomodulator, anticarcinogenic and hypocholesterolemic. The study was aimed at providing a comparative study of the production of levan from Zymomonas mobilis CCT 4494, using fermentation media sinthetic and sugarcane juice as this is considered a low cost substrate for the commercial fermentation process, due to its abundance and easy

  9. Does Intellectual Disability Affect the Development of Dental Caries in Patients with Cerebral Palsy?

    Science.gov (United States)

    Moreira, Rafaela Nogueira; Alcantara, Carlos Eduardo Pinto; Mota-Veloso, Isabella; Marinho, Sandra Aparecida; Ramos-Jorge, Maria L.; Oliveira-Ferreira, Fernanda

    2012-01-01

    The aim of this study was to evaluate if the severity of intellectual disability is a factor that affects the development of dental cavities in patients with cerebral palsy. This cross-sectional study was conducted on 165 individuals who were selected from a physical rehabilitation center, a special public school and a regular public school. Of…

  10. Factors that Affect Emergent Literacy Development When Engaging with Electronic Books

    Science.gov (United States)

    Salmon, Lynda G.

    2014-01-01

    This article reviews extant literature with the purpose of identifying factors that affect the potential efficacy of electronic books to support literacy development during early childhood. Selection criteria include experimental, quasi-experimental, and observational studies from peer-reviewed journals from 2000 to 2013 with a target population…

  11. The Effect of Differentiation Approach Developed on Creativity of Gifted Students: Cognitive and Affective Factors

    Science.gov (United States)

    Altintas, Esra; Özdemir, Ahmet S.

    2015-01-01

    The aim of the study is to develop a differentiation approach for the mathematics education of gifted middle school students and to determine the effect of the differentiation approach on creative thinking skills of gifted students based on both cognitive and affective factors. In this context, the answer to the following question was searched:…

  12. Dogs in the Hall: A Case Study of Affective Skill Development in an Urban Veterinary Program

    Science.gov (United States)

    Martin, Michael; Tummons, John; Ball, Anna; Bird, William

    2014-01-01

    The purpose of this bounded single case study was to explore how an urban high school veterinary program impacted students' affective skill development. The program was unique because students were required to participate in internships with local animal care businesses and care for animals within the school veterinary laboratory. The…

  13. Factors affecting the development of sprays produced by multihole injectors for direct-injection engine applications

    OpenAIRE

    Van Romunde, R. Z.

    2011-01-01

    The spray form development from a state of the art multi-hole injector for gasoline direct injection internal combustion engines is examined to attempt to determine the thermo-fluid dynamics affecting the spray development. The current state of knowledge regarding spray break-up and the interactivity of the factors on spray form are detailed. The spray under investigation was injected into purposely designed quiescent chambers to decouple the effects of the fluid mechanics on s...

  14. Factors Affecting the Development of ICT Competencies of Teachers in Primary Schools

    OpenAIRE

    Vitanova, Vasilka; Atanasova-Pacemska, Tatjana; Iliev, Dean; Pachemska, Sanja

    2015-01-01

    A research was conducted in order to ensure valid and reliable assessment of the extent of ICT knowledge and skills of teachers in primary schools, to identify the factors in terms of teachers affecting the development of ICT competences, and to identify strategies to improve the development of effectiveness in the future. The research surveyed 220 teachers from 10 primary schools of Macedonia. The Technique SEM was used to determine the relative strength of influence of factors on ICT compet...

  15. How does blastomere removal affect embryonic development? : A time-lapse analysis

    DEFF Research Database (Denmark)

    Kirkegaard, Kirstine; Hindkjær, Johnny Juhl; Ingerslev, Hans Jakob

    of the 6-10 cell embryo. It has been argued that blastomere removal does not affect embryonic development, but few studies have focussed on safety of the procedure. Recently, time-lapse studies on mice have suggested that blastomere removal affects embryonic development. The present study was...... conducted to evaluate the effect of blastomere biopsy on early human embryonic development using time-lapse analysis. Materials and methods: Couples undergoing IVF treatment or PGD were requested permission to include embryos in the project. The diagnosis healthy/diseased was made by analysis of a single...... as medians with 95% confidence intervals. P values under 0.05 are considered significant. Results: Until biopsy embryos in the two groups followed the same developmental pattern. After biopsy PGD embryos reached subsequent embryonic stages at significantly later time-points (pcompaction=0...

  16. Fixing the Problem With Empathy: Development and Validation of the Affective and Cognitive Measure of Empathy.

    Science.gov (United States)

    Vachon, David D; Lynam, Donald R

    2016-04-01

    Low empathy is a criterion for most externalizing disorders, and empathy training is a regular component of treatment for aggressive people, from school bullies to sex offenders. However, recent meta-analytic evidence suggests that current measures of empathy explain only 1% of the variance in aggressive behavior. A new assessment of empathy was developed to more fully represent the empathy construct and better predict important outcomes-particularly aggressive behavior and externalizing psychopathology. Across three independent samples (N = 210-708), the 36-item Affective and Cognitive measure of Empathy (ACME) was internally consistent, structurally reliable, and invariant across sex. The ACME bore significant associations to important outcomes, which were incremental relative to other measures of empathy and generalizable across sex. Importantly, the affective scales of the ACME-particularly a new "Affective Dissonance" scale-yielded moderate to strong associations with aggressive behavior and externalizing disorders. The ACME is a short, reliable, and useful measure of empathy. PMID:25612628

  17. Does Household Food Security Affect Cognitive and Social Development of Kindergartners?

    OpenAIRE

    Stormer, Ame; HARRISON, GAIL G.

    2003-01-01

    The development in the last decade of methodology for measuring and scaling household food insecurity and hunger in U.S. populations makes possible systematic examination of the ways in which hunger and food insecurity affect individuals and families. The impact on children has always been of primary concern for policy, advocacy, and science because of the vulnerability of children to long-term developmental sequelae. There is an emerging and rapidly growing literature demonstrating deletriou...

  18. Affective and Cognitive Characteristics of Nigerian Student-Teachers : towards Developing an Effective Teacher Education Framework

    OpenAIRE

    Adeosun, Oyenike; Oladipo, Bayo; Oni, Adesoji

    2013-01-01

    The study seeks to analyze the affective and cognitive traits of teacher trainees in higher educational institutions in Nigeria. This is with the view to develop an effective teacher education framework by using inputs from the trainees, in-service teachers and teacher educators and to incorporate their ideas into the structuring and organization of not only the educational programmes but also the admission processes into such programmes. Using inputs from classroom teachers, teacher trainees...

  19. How health insurance affects the delivery of health care in developing countries

    OpenAIRE

    Kutzin, Joseph; Barnum, Howard

    1992-01-01

    Financial crisis is a common state of affairs in the government health sector of many developing countries, and an increasing number are considering implementing user charges and insurance programs to shift some of the financial burden for health services away from direct budget allocations by a health ministry. Although they are often implemented as ways of mobilizing additional resources, prices and insurance also affect the allocation of health resources by changing the signals sent to pro...

  20. Developing a model of factors affecting the customer satisfaction in traditional and electronic banking

    OpenAIRE

    Hamed Heidari; Morteza Mousakhani

    2015-01-01

    Electronic banking is among the major electronic services in electronic commerce, but the lack of appropriate tool for measurement of customer satisfaction in banking industry has diminished the speed of electronic banking development. This study aims at investigating the factors affecting the customer satisfaction in traditional and electronic banking industry in order to determine the factors which lead to the customer satisfaction. Therefore, the factors, namely, the traditional service qu...

  1. ARTIE: An Integrated Environment for the Development of Affective Robot Tutors

    Science.gov (United States)

    Imbernón Cuadrado, Luis-Eduardo; Manjarrés Riesco, Ángeles; De La Paz López, Félix

    2016-01-01

    Over the last decade robotics has attracted a great deal of interest from teachers and researchers as a valuable educational tool from preschool to highschool levels. The implementation of social-support behaviors in robot tutors, in particular in the emotional dimension, can make a significant contribution to learning efficiency. With the aim of contributing to the rising field of affective robot tutors we have developed ARTIE (Affective Robot Tutor Integrated Environment). We offer an architectural pattern which integrates any given educational software for primary school children with a component whose function is to identify the emotional state of the students who are interacting with the software, and with the driver of a robot tutor which provides personalized emotional pedagogical support to the students. In order to support the development of affective robot tutors according to the proposed architecture, we also provide a methodology which incorporates a technique for eliciting pedagogical knowledge from teachers, and a generic development platform. This platform contains a component for identiying emotional states by analysing keyboard and mouse interaction data, and a generic affective pedagogical support component which specifies the affective educational interventions (including facial expressions, body language, tone of voice,…) in terms of BML (a Behavior Model Language for virtual agent specification) files which are translated into actions of a robot tutor. The platform and the methodology are both adapted to primary school students. Finally, we illustrate the use of this platform to build a prototype implementation of the architecture, in which the educational software is instantiated with Scratch and the robot tutor with NAO. We also report on a user experiment we carried out to orient the development of the platform and of the prototype. We conclude from our work that, in the case of primary school students, it is possible to identify, without

  2. ARTIE: An Integrated Environment for the Development of Affective Robot Tutors.

    Science.gov (United States)

    Imbernón Cuadrado, Luis-Eduardo; Manjarrés Riesco, Ángeles; De La Paz López, Félix

    2016-01-01

    Over the last decade robotics has attracted a great deal of interest from teachers and researchers as a valuable educational tool from preschool to highschool levels. The implementation of social-support behaviors in robot tutors, in particular in the emotional dimension, can make a significant contribution to learning efficiency. With the aim of contributing to the rising field of affective robot tutors we have developed ARTIE (Affective Robot Tutor Integrated Environment). We offer an architectural pattern which integrates any given educational software for primary school children with a component whose function is to identify the emotional state of the students who are interacting with the software, and with the driver of a robot tutor which provides personalized emotional pedagogical support to the students. In order to support the development of affective robot tutors according to the proposed architecture, we also provide a methodology which incorporates a technique for eliciting pedagogical knowledge from teachers, and a generic development platform. This platform contains a component for identiying emotional states by analysing keyboard and mouse interaction data, and a generic affective pedagogical support component which specifies the affective educational interventions (including facial expressions, body language, tone of voice,…) in terms of BML (a Behavior Model Language for virtual agent specification) files which are translated into actions of a robot tutor. The platform and the methodology are both adapted to primary school students. Finally, we illustrate the use of this platform to build a prototype implementation of the architecture, in which the educational software is instantiated with Scratch and the robot tutor with NAO. We also report on a user experiment we carried out to orient the development of the platform and of the prototype. We conclude from our work that, in the case of primary school students, it is possible to identify, without

  3. Systematic Analysis on Factors Affecting the Development of Rural Tourism: A Case Study of Chengdu

    Institute of Scientific and Technical Information of China (English)

    HeJing-ming; LiHui-xia

    2003-01-01

    Based on field survey, the thesis analyzes the key factors affecting development of rural tourism systematically,taking Chengdu as an example. These factors include regional economic development level & leisure tradition, tourist market & traffic, tourist resource, spatial agglomeration and competition of rural tourism, and decision-making behavior. Among them,regional economic development level & leisure tradition and tourist market & traffic are prerequisites for the development of rural tourism which have an impact on tourist ''s consumption level,consumption custom, operator''s investment ability, tourist destination distribution and scale; Tourist resource, spatial agglomeration and competition of rural tourism are restrictive conditions affecting character and distribution of rural tourism; Government''s decision-making behavior is of importance for expansion of scale and popularity of regional rural tourism, meanwhile, operators'' decision-making behavior includes investment scale and operational strategies, and for operators from the outside, location selection is included additionally. All these decision-making behaviors are subjective conditions for the development of rural tourism.

  4. Prepubertal tamoxifen treatment affects development of heifer reproductive tissues and related signaling pathways.

    Science.gov (United States)

    Al Naib, A; Tucker, H L M; Xie, G; Keisler, D H; Bartol, F F; Rhoads, R P; Akers, R M; Rhoads, M L

    2016-07-01

    Prepubertal exposure of the developing ovaries and reproductive tract (RT) to estrogen or xenoestrogens can have acute and long-term consequences that compromise the reproductive performance of cattle. This research examined effects of the selective estrogen receptor modulator tamoxifen (TAM) on gene and protein abundance in prepubertal ovaries and RT, with a particular focus on signaling pathways that affect morphology. Tamoxifen was administered to Holstein heifer calves (n=8) daily (0.3mg/kg subcutaneously) from 28 to 120 d of age, when tissues were collected. Control calves (n=7) received an equal volume of excipient. Weight, gross measurements, and samples of reproductive tissues were collected, and protein and mRNA were extracted from snap-frozen samples of vagina, cervix, uterus, oviduct, ovary, and liver. Neither estradiol nor insulin-like growth factor I (IGFI) concentrations in the serum were affected by TAM treatment. Tamoxifen treatment reduced ovarian weight independently from effects on antral follicle populations, as there was no difference in visible antral follicle numbers on the day of collection. Estrogen receptor α (ESR1) and β (ESR2) mRNA, ESR1 protein, IGFI, progesterone receptor, total growth hormone receptor, WNT4, WNT5A, and WNT7A mRNA, in addition to mitogen-activated protein kinase (MAPK) and phosphorylated MAPK proteins were affected differently depending on the tissue examined. However, neither IGFI receptor mRNA nor protein abundance were affected by TAM treatment. Results indicate that reproductive development in prepubertal Holstein heifer calves is TAM-sensitive, and that bovine RT and ovarian development are supported, in part, by estrogen receptor-dependent mechanisms during the period studied here. Potential long-term consequences of such developmental disruption remain to be defined. PMID:27085397

  5. Institutional Guidance of Affective Bonding: Moral Values Development in Brazilian Military Education.

    Science.gov (United States)

    Wortmeyer, Daniela Schmitz; Branco, Angela Uchoa

    2016-09-01

    In this article, our aim is to analyze institutional practices guided to promote the development of moral values within the context of military education of Brazilian Army combatant commissioned officers. From a cultural psychological approach, we discuss how social guidance within military culture operates at different levels of the affective-semiotic regulation of individuals, structuring complex experiences that give rise to hypergeneralized meaning fields regarding morality and military values. For this goal, we first introduce some theoretical topics related to values development, emphasizing their affective roots and role in the emergence, maintenance, amplification and attenuation of all relations between the person and the environment. Following a brief discussion on how social institutions try to promote changes in personal values, we provide an overview of values present in the military culture and socialization. Finally, the text focuses on the education of Brazilian Army combatant commissioned officers, describing how practices related to different levels of affective-semiotic experience combine in order to promote the internalization and externalization of specific moral values. We conclude suggesting issues for future investigation. PMID:26960934

  6. Negative affect is associated with development and persistence of chemical intolerance

    DEFF Research Database (Denmark)

    Skovbjerg, Sine; Christensen, Karl Bang; Ebstrup, Jeanette Frost; Linneberg, Allan; Zachariae, Robert; Elberling, Jesper

    2015-01-01

    OBJECTIVE: Chemical intolerance (CI) is characterised by negative health effects attributed to a heightened responsiveness to common airborne chemicals. This longitudinal study explored the hypothesised role of negative affect in the development and persistence of CI in a general population...... were classified as reporting no signs of CI, having symptoms of CI and as being a likely CI case based on self-reported reactions to 11 common chemical exposures, symptoms related to chemical exposures and daily life adjustments attributed to reactions when exposed to chemicals. RESULTS: A total of 69.......4% of the participants who had reported CI at baseline also reported CI at follow-up. In participants with no baseline CI, 15.5% reported CI at follow-up and 18.1% reported symptoms related to chemicals but no daily life adjustments. Baseline negative affect was positively and statistically...

  7. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.

    Science.gov (United States)

    Wu, Kong-Yan; Zuo, Guo-Long; Li, Xiao-Feng; Ye, Qing; Deng, Yong-Qiang; Huang, Xing-Yao; Cao, Wu-Chun; Qin, Cheng-Feng; Luo, Zhen-Ge

    2016-06-01

    The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies. PMID:27174054

  8. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

    Science.gov (United States)

    Wu, Kong-Yan; Zuo, Guo-Long; Li, Xiao-Feng; Ye, Qing; Deng, Yong-Qiang; Huang, Xing-Yao; Cao, Wu-Chun; Qin, Cheng-Feng; Luo, Zhen-Ge

    2016-01-01

    The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies. PMID:27174054

  9. SPL8, an SBP-box gene that affects pollen sac development in Arabidopsis.

    Science.gov (United States)

    Unte, Ulrike S; Sorensen, Anna-Marie; Pesaresi, Paolo; Gandikota, Madhuri; Leister, Dario; Saedler, Heinz; Huijser, Peter

    2003-04-01

    SQUAMOSA PROMOTER BINDING PROTEIN-box genes (SBP-box genes) encode plant-specific proteins that share a highly conserved DNA binding domain, the SBP domain. Although likely to represent transcription factors, little is known about their role in development. In Arabidopsis, SBP-box genes constitute a structurally heterogeneous family of 16 members known as SPL genes. For one of these genes, SPL8, we isolated three independent transposon-tagged mutants, all of which exhibited a strong reduction in fertility. Microscopic analysis revealed that this reduced fertility is attributable primarily to abnormally developed microsporangia, which exhibit premeiotic abortion of the sporocytes. In addition to its role in microsporogenesis, the SPL8 knockout also seems to affect megasporogenesis, trichome formation on sepals, and stamen filament elongation. The SPL8 mutants described help to uncover the roles of SBP-box genes in plant development. PMID:12671094

  10. Decision analysis and risk models for land development affecting infrastructure systems.

    Science.gov (United States)

    Thekdi, Shital A; Lambert, James H

    2012-07-01

    Coordination and layering of models to identify risks in complex systems such as large-scale infrastructure of energy, water, and transportation is of current interest across application domains. Such infrastructures are increasingly vulnerable to adjacent commercial and residential land development. Land development can compromise the performance of essential infrastructure systems and increase the costs of maintaining or increasing performance. A risk-informed approach to this topic would be useful to avoid surprise, regret, and the need for costly remedies. This article develops a layering and coordination of models for risk management of land development affecting infrastructure systems. The layers are: system identification, expert elicitation, predictive modeling, comparison of investment alternatives, and implications of current decisions for future options. The modeling layers share a focus on observable factors that most contribute to volatility of land development and land use. The relevant data and expert evidence include current and forecasted growth in population and employment, conservation and preservation rules, land topography and geometries, real estate assessments, market and economic conditions, and other factors. The approach integrates to a decision framework of strategic considerations based on assessing risk, cost, and opportunity in order to prioritize needs and potential remedies that mitigate impacts of land development to the infrastructure systems. The approach is demonstrated for a 5,700-mile multimodal transportation system adjacent to 60,000 tracts of potential land development. PMID:22050390

  11. All negative affects are not equal: Anxiety but not depression predicts risk-taking

    NARCIS (Netherlands)

    Rago, V. di; Panno, A.; Lauriola, M.; Figner, B.C.

    2012-01-01

    Using two behavioral risk tasks (Balloon Analogue Risk Task BART; Lejuez et al. 2002 and Columbia Card Task, CCT; Figner et al. 2009) that mimic important features of real-world risk taking behaviors, we investigated the effects of different types of negative affect on risk taking. Methods: Particip

  12. Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster.

    Science.gov (United States)

    Marcus, Sarah R; Fiumera, Anthony C

    2016-01-01

    Atrazine is the one of the most widely used herbicides in the United States and non-target organisms may encounter it in the environment. Atrazine is known to affect male reproduction in both vertebrates and invertebrates but less is known about its effects on other fitness traits. Here we assessed the effects of five different chronic exposure levels on a variety of fitness traits in Drosophila melanogaster. We measured male and female longevity, development time, proportion pupated, proportion emerged, body size, female mating rate, fertility and fecundity. Atrazine exposure decreased the proportion pupated, the proportion emerged and adult survival. Development time was also affected by atrazine and exposed flies pupated and emerged earlier than controls. Although development time was accelerated, body size was actually larger in some of the exposures. Atrazine exposure had no effect on female mating rate and the effects on female fertility and fecundity were only observed in one of the two independent experimental blocks. Many of the traits showed non-monotonic dose response curves, where the intermediate concentrations showed the largest effects. Overall this study shows that atrazine influences a variety of life history traits in the model genetic system, D. melanogaster, and future studies should aim to identify the molecular mechanisms of toxicity. PMID:27317622

  13. Insight on Genes Affecting Tuber Development in Potato upon Potato spindle tuber viroid (PSTVd) Infection

    Science.gov (United States)

    Zhang, Runxuan; Bonar, Nicola; Morris, Jenny; Hedley, Pete E.; Bryan, Glenn J.; Kalantidis, Kriton; Hornyik, Csaba

    2016-01-01

    Potato (Solanum tuberosum L) is a natural host of Potato spindle tuber viroid (PSTVd) which can cause characteristic symptoms on developing plants including stunting phenotype and distortion of leaves and tubers. PSTVd is the type species of the family Pospiviroidae, and can replicate in the nucleus and move systemically throughout the plant. It is not well understood how the viroid can affect host genes for successful invasion and which genes show altered expression levels upon infection. Our primary focus in this study is the identification of genes which can affect tuber formation since viroid infection can strongly influence tuber development and especially tuber shape. In this study, we used a large-scale method to identify differentially expressed genes in potato. We have identified defence, stress and sugar metabolism related genes having altered expression levels upon infection. Additionally, hormone pathway related genes showed significant up- or down-regulation. DWARF1/DIMINUTO, Gibberellin 7-oxidase and BEL5 transcripts were identified and validated showing differential expression in viroid infected tissues. Our study suggests that gibberellin and brassinosteroid pathways have a possible role in tuber development upon PSTVd infection. PMID:26937634

  14. THE RICHNESS OF THE ENVIRONMENT AFFECTS VISUAL SYSTEM DEVELOPMENT: A ROLE FOR IGF-1

    OpenAIRE

    Roberta Narducci

    2014-01-01

    A pre-weaning enriched experience is sufficient to affect maturation of the visual system, suggesting that factors influenced by the environment during the first days of life might prime visual circuits towards a faster development. Here, we showed that IGF-1 levels are increased in the visual cortex of EE rats as early as P6 and this is a crucial event for setting in motion the developmental program induced by EE. Early intracerebroventricular (i.c.v.) infusion of IGF-1 in standard rats was ...

  15. Development of a diagnosis index of tropical cyclones affecting the Korean Peninsula

    Science.gov (United States)

    Choi, Jae-Won; Cha, Yumi

    2016-06-01

    This study has developed the index for diagnosis on possibility that tropical cyclones (TCs) affect Korean Peninsula. This index is closely related to the strength of the western North Pacific subtropical high (WNPSH), which is calculated as a difference in meridional wind between at the highest correlation area (around Korean Peninsula) and at the lowest correlation area (sea southeast of Japan) through a correlation analysis between TC frequency that affects Korean Peninsula and 500 hPa meridional wind. In low frequency years that selected from Korea affecting TC index, anomalous northeasterly is strengthened from Korea to the South China Sea because the center of anomalous anticyclonic circulation is located to northwest of Korean Peninsula. Thus, TCs tend to move westward from the sea east of the Philippines to the mainland China. On the other hand, in high frequency years, anomalous southwesterly serves as steering flow that more TCs move toward Korean Peninsula because the center of anomalous anticyclonic circulation is located to sea east of Japan. Consequently, this study suggests that if this index is calculated using real time 500 hPa meridional winds that forecasted by dynamic models during the movement of TCs, the possibility that TCs approach Korean Peninsula can be diagnosed in real time.

  16. Children affected by HIV/AIDS: SAFE, a model for promoting their security, health, and development.

    Science.gov (United States)

    Betancourt, Theresa S; Fawzi, Mary K S; Bruderlein, Claude; Desmond, Chris; Kim, Jim Y

    2010-05-01

    A human security framework posits that individuals are the focus of strategies that protect the safety and integrity of people by proactively promoting children's well being, placing particular emphasis on prevention efforts and health promotion. This article applies this framework to a rights-based approach in order to examine the health and human rights of children affected by HIV/AIDS. The SAFE model describes sources of insecurity faced by children across four fundamental dimensions of child well-being and the survival strategies that children and families may employ in response. The SAFE model includes: Safety/protection; Access to health care and basic physiological needs; Family/connection to others; and Education/livelihoods. We argue that it is critical to examine the situation of children through an integrated lens that effectively looks at human security and children's rights through a holistic approach to treatment and care rather than artificially limiting our scope of work to survival-oriented interventions for children affected by HIV/AIDS. Interventions targeted narrowly at children, in isolation of their social and communal environment as outlined in the SAFE model, may in fact undermine protective resources in operation in families and communities and present additional threats to children's basic security. An integrated approach to the basic security and care of children has implications for the prospects of millions of children directly infected or indirectly affected by HIV/AIDS around the world. The survival strategies that young people and their families engage in must be recognized as a roadmap for improving their protection and promoting healthy development. Although applied to children affected by HIV/AIDS in the present analysis, the SAFE model has implications for guiding the care and protection of children and families facing adversity due to an array of circumstances from armed conflict and displacement to situations of extreme poverty

  17. International trends affecting the development of small and medium sized reactors

    International Nuclear Information System (INIS)

    The beginning of the 21st century is characterised by significant changes in the energy policy-making framework of most countries. Globalisation of the world economy, deregulation of electricity markets, privatisation of the electricity sector, increasing concerns about the need to protect the environment and awareness of sustainable development goals are among the major trends affecting policy making and decisions in the energy sector. All those factors have impacts on nuclear energy programmes and may affect SMR development in particular. The paper investigates how those factors may change national energy policies and impact on nuclear energy programmes, with special emphasis on the potential role of SMRs in energy supply mixes. It elaborates on recent trends to increasing reliance on market mechanisms in the energy and electricity sectors and on the role of governments in implementing an integrated approach to policy making, within a sustainable development framework incorporating economic, social and environmental dimensions. Against this backdrop, the paper examines the potential markets for SMRs, taking into account their possible uses beyond electricity generation, such as potable water production, cogeneration, process or domestic heat supply and eventually hydrogen production. It reviews key issues to be addressed in order to facilitate the deployment of SMRs in different countries. Those include technology progress and transfer, capacity building in developing countries, adaptation to market requirements, economic competitiveness and social acceptance. The paper concludes with remarks regarding the importance of international co-operation, especially in the field of research and development on advanced reactor and fuel cycle concepts. In this connection, the role of intergovernmental organisations as facilitators and catalysts of national efforts is highlighted. (author)

  18. Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa.

    Directory of Open Access Journals (Sweden)

    Antonio M Mendes

    2008-05-01

    Full Text Available In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient laboratory studies have identified mosquito genes that affect positively or negatively the developmental cycle of the model rodent parasite, P. berghei. Here, we use transcription profiling and reverse genetics to explore whether five disparate mosquito gene regulators of P. berghei development are also pertinent to A. gambiae/P. falciparum interactions in semi-natural conditions, using field isolates of this parasite and geographically related mosquitoes. We detected broadly similar albeit not identical transcriptional responses of these genes to the two parasite species. Gene silencing established that two genes affect similarly both parasites: infections are hindered by the intracellular local activator of actin cytoskeleton dynamics, WASP, but promoted by the hemolymph lipid transporter, ApoII/I. Since P. berghei is not a natural parasite of A. gambiae, these data suggest that the effects of these genes have not been drastically altered by constant interaction and co-evolution of A. gambiae and P. falciparum; this conclusion allowed us to investigate further the mode of action of these two genes in the laboratory model system using a suite of genetic tools and infection assays. We showed that both genes act at the level of midgut invasion during the parasite's developmental transition from ookinete to oocyst. ApoII/I also affects the early stages of oocyst development. These are the first mosquito genes whose significant effects on P. falciparum field isolates have been established by direct experimentation. Importantly, they validate for semi-field human malaria transmission the concept of parasite antagonists and agonists.

  19. Polycyclic aromatic hydrocarbons affect survival and development of common snapping turtle (Chelydra serpentina) embryos and hatchlings

    International Nuclear Information System (INIS)

    Polycyclic aromatic hydrocarbons (PAHs) are toxic compounds found in the John Heinz National Wildlife Refuge in Philadelphia, Pennsylvania. We assessed the impact of PAHs and crude oil on snapping turtle development and behavior by exposing snapping turtle eggs from the Refuge and from three clean reference sites to individual PAHs or a crude oil mixture at stage 9 of embryonic development. Exposure to PAHs had a significant effect on survival rates in embryos from one clean reference site, but not in embryos from the other sites. There was a positive linear relationship between level of exposure to PAHs and severity of deformities in embryos collected from two of the clean reference sites. Neither righting response nor upper temperature tolerance (critical thermal maximum, CTM) of snapping turtle hatchlings with no or minor deformities was significantly affected by exposure to PAHs. - Exposure to polycyclic aromatic hydrocarbons on the egg reduces survival of snapping turtle embryos and causes developmental abnormalities

  20. Development of Food Retailing and Factors Affecting the Competition in Food Retailing

    Directory of Open Access Journals (Sweden)

    Serkan Kilic

    2010-04-01

    Full Text Available Retailing is a dynamic and complex sector that offers wide range of products and services to consumers. This sector which includes different types of enterprises, has an important position within the supply chain. Food retailing has also a big potential within retailing sector. On the other hand, an intensive competition exists in food retailing. Taking place in the competitive market, food retailers attempt to gain a competitive advantage against their rivals with their geographic location, product selection and type, offered service quality and pricing alternatives. Additionally, food retailers also incline to develop their own branded products. The purpose of this study is to examine the development of food retailing sector, competitive structure and the main factors affecting this structure.

  1. Polycyclic aromatic hydrocarbons affect survival and development of common snapping turtle (Chelydra serpentina) embryos and hatchlings

    Energy Technology Data Exchange (ETDEWEB)

    Van Meter, Robin J. [School of Environmental Science, Engineering, and Policy and Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 (United States)]. E-mail: robinjvanmeter@yahoo.com; Spotila, James R. [School of Environmental Science, Engineering, and Policy and Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 (United States)]. E-mail: spotiljr@drexel.edu; Avery, Harold W. [School of Environmental Science, Engineering, and Policy and Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 (United States)]. E-mail: Haltort@aol.com

    2006-08-15

    Polycyclic aromatic hydrocarbons (PAHs) are toxic compounds found in the John Heinz National Wildlife Refuge in Philadelphia, Pennsylvania. We assessed the impact of PAHs and crude oil on snapping turtle development and behavior by exposing snapping turtle eggs from the Refuge and from three clean reference sites to individual PAHs or a crude oil mixture at stage 9 of embryonic development. Exposure to PAHs had a significant effect on survival rates in embryos from one clean reference site, but not in embryos from the other sites. There was a positive linear relationship between level of exposure to PAHs and severity of deformities in embryos collected from two of the clean reference sites. Neither righting response nor upper temperature tolerance (critical thermal maximum, CTM) of snapping turtle hatchlings with no or minor deformities was significantly affected by exposure to PAHs. - Exposure to polycyclic aromatic hydrocarbons on the egg reduces survival of snapping turtle embryos and causes developmental abnormalities.

  2. Prenatal low-dose X-irradiation affects connexins 43 and 26 in developing mouse neocortex

    International Nuclear Information System (INIS)

    To investigate the effects of low-dose X-irradiation on the expression of connexins (Cxs) in developing cerebral cortex, C57/BL6 pregnant mice were exposed to whole body irradiation of 0.1 Gy and 0.5 Gy, on embryonic day 14.5. Fetal telencephalons, at 1, 3, 12 and 24 hr after exposure, were studied immunohistochemically using anti-Cx43 and Cx26 antibodies, followed by quantitative image analyses. Cx43 expression was significantly reduced in all zones of developing cerebral cortex until 12 hr after exposure, and tended to recover to control level after 24 hr. Cx26 expression was also suppressed in the ventricular zone and cortical plate after irradiation, although it recovered much earlier. Our observations indicate that the expression of Cxs is affected by ionizing radiation during cortical histogenesis. (author)

  3. Developing fragility functions for the areas affected by the 2009 Samoa earthquake and tsunami

    Directory of Open Access Journals (Sweden)

    H. Gokon

    2014-01-01

    Full Text Available Fragility functions in terms of flow depth, flow velocity and hydrodynamic force are developed to evaluate structural vulnerability in the areas affected by the 2009 Samoa earthquake and tsunami. First, numerical simulations of tsunami propagation and inundation are conducted to reproduce the features of tsunami inundation. To validate the results, flow depths measured in field surveys and waveforms measured by Deep-ocean Assessment and Reporting of Tsunamis (DART gauges are utilized. Next, building damage is investigated by manually detecting changes between pre- and post-tsunami high-resolution satellite images. Finally, the data related to tsunami features and building damage are integrated using GIS, and tsunami fragility functions are developed based on the statistical analyses.

  4. From infant affect expression to symbolic play: the coherence of development in Down syndrome children.

    Science.gov (United States)

    Motti, F; Cicchetti, D; Sroufe, L A

    1983-10-01

    To examine further the coherence of development of a sample of Down syndrome children, assessments were made of the quality and level of play at age 3-5 years. It was found that, with corrections for mental age, the play of these children was similar to that of nonhandicapped children. Moreover, individual differences in the level and quality of play were strongly predicted from Bayley DQ scores obtained at age 2 and by several indexes of affective expressiveness including 1 obtained in the first year of life. This was despite limitations on the performance range represented in the subsample included in this follow-up study. Finally, the various aspects of play, as indexed by 5 separate scales, intercorrelated strongly, suggesting consistent individual differences in the play session itself. All of these findings point to the coherence of development of these children. In addition, it is suggested that early affective assessments are strong predictors of the later functioning of Down syndrome. PMID:6194942

  5. Ectopic expression of TAPETUM DETERMINANT1 affects ovule development in Arabidopsis.

    Science.gov (United States)

    Huang, Jian; Wijeratne, Asela J; Tang, Chong; Zhang, Tianyu; Fenelon, Rebecca E; Owen, Heather A; Zhao, Dazhong

    2016-03-01

    Plants have evolved to extensively employ leucine-rich repeat receptor-like kinases (LRR-RLKs), the largest family of RLKs, to control growth, development, and defense. In Arabidopsis thaliana, the EXCESS MICROSPOROCYTES1 (EMS1) LRR-RLK and its potential small protein ligand TAPETUM DETERMINANT1 (TPD1) are specifically required for anther cell differentiation; however, TPD1 and EMS1 orthologs also control megaspore mother cell proliferation in rice and maize ovules. Here, the molecular function of TPD1 was demonstrated during ovule development in Arabidopsis using a gain-of-function approach. In ovules, the EMS1 gene was primarily expressed in nucellus epidermis and chalaza, whereas the expression of TPD1 was weakly restricted to the distal end of integuments. Ectopic expression of TPD1 caused pleiotropic defects in ovule and seed development. RNA sequencing analysis showed that ectopic expression of TPD1 altered expression of auxin signaling genes and core cell-cycle genes during ovule development. Moreover, ectopic expression of TPD1 not only affected auxin response but also enhanced expression of cyclin genes CYCD3;3 and CYCA2;3 in ovules. Thus, these results provide insight into the molecular mechanism by which TPD1-EMS1 signaling controls plant development possibly via regulation of auxin signaling and cell-cycle genes. PMID:26685185

  6. Induced autoimmunity against gonadal proteins affects gonadal development in juvenile zebrafish.

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    Christopher Presslauer

    Full Text Available A method to mitigate or possibly eliminate reproduction in farmed fish is highly demanded. The existing approaches have certain applicative limitations. So far, no immunization strategies affecting gonadal development in juvenile animals have been developed. We hypothesized that autoimmune mechanisms, occurring spontaneously in a number of diseases, could be induced by targeted immunization. We have asked whether the immunization against specific targets in a juvenile zebrafish gonad will produce an autoimmune response, and, consequently, disturbance in gonadal development. Gonadal soma-derived factor (Gsdf, growth differentiation factor (Gdf9, and lymphocyte antigen 75 (Cd205/Ly75, all essential for early gonad development, were targeted with 5 immunization tests. Zebrafish (n = 329 were injected at 6 weeks post fertilization, a booster injection was applied 15 days later, and fish were sampled at 30 days. We localized transcripts encoding targeted proteins by in situ hybridization, quantified expression of immune-, apoptosis-, and gonad-related genes with quantitative real-time PCR, and performed gonadal histology and whole-mount immunohistochemistry for Bcl2-interacting-killer (Bik pro-apoptotic protein. The treatments resulted in an autoimmune reaction, gonad developmental retardation, intensive apoptosis, cell atresia, and disturbed transcript production. Testes were remarkably underdeveloped after anti-Gsdf treatments. Anti-Gdf9 treatments promoted apoptosis in testes and abnormal development of ovaries. Anti-Cd205 treatment stimulated a strong immune response in both sexes, resulting in oocyte atresia and strong apoptosis in supporting somatic cells. The effect of immunization was FSH-independent. Furthermore, immunization against germ cell proteins disturbed somatic supporting cell development. This is the first report to demonstrate that targeted autoimmunity can disturb gonadal development in a juvenile fish. It shows a

  7. Induced Autoimmunity against Gonadal Proteins Affects Gonadal Development in Juvenile Zebrafish

    Science.gov (United States)

    Presslauer, Christopher; Nagasawa, Kazue; Dahle, Dalia; Babiak, Joanna; Fernandes, Jorge M. O.; Babiak, Igor

    2014-01-01

    A method to mitigate or possibly eliminate reproduction in farmed fish is highly demanded. The existing approaches have certain applicative limitations. So far, no immunization strategies affecting gonadal development in juvenile animals have been developed. We hypothesized that autoimmune mechanisms, occurring spontaneously in a number of diseases, could be induced by targeted immunization. We have asked whether the immunization against specific targets in a juvenile zebrafish gonad will produce an autoimmune response, and, consequently, disturbance in gonadal development. Gonadal soma-derived factor (Gsdf), growth differentiation factor (Gdf9), and lymphocyte antigen 75 (Cd205/Ly75), all essential for early gonad development, were targeted with 5 immunization tests. Zebrafish (n = 329) were injected at 6 weeks post fertilization, a booster injection was applied 15 days later, and fish were sampled at 30 days. We localized transcripts encoding targeted proteins by in situ hybridization, quantified expression of immune-, apoptosis-, and gonad-related genes with quantitative real-time PCR, and performed gonadal histology and whole-mount immunohistochemistry for Bcl2-interacting-killer (Bik) pro-apoptotic protein. The treatments resulted in an autoimmune reaction, gonad developmental retardation, intensive apoptosis, cell atresia, and disturbed transcript production. Testes were remarkably underdeveloped after anti-Gsdf treatments. Anti-Gdf9 treatments promoted apoptosis in testes and abnormal development of ovaries. Anti-Cd205 treatment stimulated a strong immune response in both sexes, resulting in oocyte atresia and strong apoptosis in supporting somatic cells. The effect of immunization was FSH-independent. Furthermore, immunization against germ cell proteins disturbed somatic supporting cell development. This is the first report to demonstrate that targeted autoimmunity can disturb gonadal development in a juvenile fish. It shows a straightforward potential

  8. Governance Factors Affecting Community Participation In Public Development Projects In Meru District In Arusha In Tanzania

    Directory of Open Access Journals (Sweden)

    Jackson Estomih Muro

    2015-06-01

    Full Text Available ABSTRACT The purpose of this study was to have a fresh look at the local governance status through exploring governance factors affecting community participation in public development projects. The study also has investigated the actors and factors shaping participation as well as causes for non-participation. For the purpose of the study six wards within two divisions of Poli and Mbuguni and Meru district headquarters were selected. In the wards a total of 80 respondents from among the community members were interviewed through a structured questionnaire. Others were Village chairman Village Executive Officers Ward Executive Officers and Councilors were also interviewed and involved in the FGD. Data were analyzed using SPSS. Simple descriptive statistics and cross tabulation and figures were used in the analysis. The analysis showed that the communities were participated in the public development projects and people were participating through financial material and labor contribution to the public development projects. The analysis also showed that the government supported the ongoing public development projects including through provision of fund and expertise. The study showed the benefit of community participation in the development projects or programs like ownership of the projects and enjoying the benefits accrued from the projects. The study also indicated that there is significant change in terms of governance as influencers of community participation in public development projects. Despite the fortunes study showed some challenges found in wards and villages being the incidence of corruptions and misuse of public resources which were mentioned to slow community participation in public development projects. It was therefore concluded that adhering to the good governance principles contribute positively towards community participation in public development projects.

  9. Factors affecting the impact of professional development programs on teachers' knowledge, practice, student outcomes & efficacy.

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    Lawrence Ingvarson

    2005-01-01

    Full Text Available This report examines effects of structural and process features of professional development programs on teachers' knowledge, practice and efficacy. It is based on four recent (2002-2003 studies undertaken through the Australian Government Quality Teacher Programme, designed to enhance teacher quality. The total data set for the survey study includes 3,250 teachers who had participated in eighty individual professional development1 activities within these studies. Teachers were surveyed at least three months after participating in an activity, which provided them with the opportunity to gauge the impact of programs on their practice. To investigate factors affecting impact, a theoretical model was developed based on recent research into the characteristics of effective professional development and tested using blockwise regression analysis. The model included contextual factors (e.g., school support, structural features of programs (e.g. ,length, process features (e.g., emphasis on content; active learning; examination of student work; feedback; follow-up, a mediating variable (level of professional community generated, and four outcome measures (knowledge; practice; student learning and efficacy. Consistent significant direct effects were found across the four studies for the impact of content focus, active learning, and follow-up on knowledge and professional community. Feedback was rarely incorporated into program design. Impact on efficacy was strongly related to the perceived impact of activities on teachers' practice and student learning outcomes.

  10. Exposure to serotonin adversely affects oligodendrocyte development and myelination in vitro.

    Science.gov (United States)

    Fan, Lir-Wan; Bhatt, Abhay; Tien, Lu-Tai; Zheng, Baoying; Simpson, Kimberly L; Lin, Rick C S; Cai, Zhengwei; Kumar, Praveen; Pang, Yi

    2015-05-01

    patterns of contactin-associated protein (Caspr) clustering were observed at the sites of Node of Ranvier, suggesting that 5-HT exposure may affect other axon-derived factors for myelination. In summary, this is the first study to demonstrate that manipulation of serotonin levels affects OL development and myelination, which may contribute to altered neural connectivity noted in SSRIs-treated animals. The current in vitro study demonstrated that exposure to high level of serotonin (5-HT) led to aberrant oligodendrocyte (OL) development, cell injury, and myelination deficit. We propose that elevated extracellular serotonin levels in the fetal brain, such as upon the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy, may adversely affect OL development and/or myelination, thus contributing to altered neural connectivity seen in Autism Spectrum Disorders. OPC = oligodendrocyte progenitor cell. PMID:25382136

  11. Developing a model of factors affecting the customer satisfaction in traditional and electronic banking

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    Hamed Heidari

    2015-06-01

    Full Text Available Electronic banking is among the major electronic services in electronic commerce, but the lack of appropriate tool for measurement of customer satisfaction in banking industry has diminished the speed of electronic banking development. This study aims at investigating the factors affecting the customer satisfaction in traditional and electronic banking industry in order to determine the factors which lead to the customer satisfaction. Therefore, the factors, namely, the traditional service quality with six dimensions, the electronic service quality with three dimensions, customer satisfaction, loyalty and trust are extracted according to the literature review, and the structural equation modeling is implemented on this basis. The statistical population of research consists of customers in one of the private banks and 242 subjects are selected as the samples. The data analysis is performed by partial least squares-structural equation modeling technique (PLS-SEM using Smart PLS software. The data analysis results indicate that one dimension of electronic service quality including the telephone banking quality affect the customer satisfaction and two dimensions of traditional service quality including the complaint management and tangibility also have impact on the customer satisfaction. Moreover, the impact of customer satisfaction on the customer trust and loyalty is approved in this study.

  12. Development of the Teacher Candidates’ Level of being Affected from Public Personnel Selection Examination Scale

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    Fatma SUSAR KIRMIZI

    2016-07-01

    Full Text Available This study aimed to develop a scale to evaluate teacher candidates' level of being affected from the public personnel selection examination. The participants of the study consisted of the final year students at Pamukkale University Education Faculty. The participants were 207 teacher candidates, of whom 143 were female and 64 were male. The validity and reliability study of the scale was conducted on the data gathered from teacher candidates studying at Art Teaching, Music Teaching, Turkish Language Teaching, Social Studies Education, Science Teaching, Psychological Counseling and Guidance Education, Elementary Education and Preschool Education departments of Pamukkale University Education Faculty. The Lawshe technique was used in the evaluation of the scale by experts. To determine the construct validity, factor analysis was performed on the data, and two sub-scales were identified. The factor loading values of the items in the first sub-scale ranged between 0,65 and 0,35, and those in the second sub-scale between 0,75 and 0,39. As a result of the analyses, the "Teacher Candidates' Level of Being Affected From Public Personnel Selection Examination Scale" (TCLBAPPSES including 33 items, 23 negative and 10 positive, and two sub-scales was produced. The Cronbach's Alpha reliability coefficient was found as 0,86 for the first sub-dimension, 0,73 for the second sub-dimension, and 0,91 for the whole scale. As a result, it can be argued that the scale is reliable

  13. Opinions of Primary School Science and Technology Teachers about Developing Students’ Affective Competence

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    Bahadır Erişti

    2012-01-01

    Full Text Available The present study aimed to determine the primary school secondary level science and technology teachers’ opinions about developing students’ affective competence. It was designed as case study with qualitative research method. The participants of the study consisted of 19 science and technology teachers with at least five year experience, who works at 14 different state primary school secondary levels in Eskisehir in Turkey. The data of the study was collected through semi-structured interviews with the teachers in March-April 2010. The interview form contained 10 questions and the responses to these questions were analyzed with NVivo8.0 program through content analysis approach. The findings of the study indicated that the Science and Technology teachers agreed on the significance of gaining the affective intelligence to students, however, they had lack of information and skills on this issue. According to the participant teachers, school administrators and teachers have important responsibilities for this issue, so the teachers were in struggle for using various teaching method and techniques to gain this competence. Yet, they felt inadequate about measurement and evaluation.

  14. THE DEVELOPMENT OF ORGANIC AGRICULTURE IN CHINA AND THE FACTORS AFFECTING ORGANIC FARMING

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    Yumei Xie

    2015-06-01

    Full Text Available The aim of the paper. The aim of the paper is to evaluate the impact of factors determining the transition to organic farming and provide some recommendations for government’s policy relating to organic farming. Material and research method. An analysis was based on questionnaire survey on the willingness of organic farming by small farmers in the province of Jiangsu. Binary logistic regression model was used in the research. Concluding remarks. Five factors affecting organic agricultural production were discovered: farmers’ age, risk preferences, labour costs, expected benefi ts and the environment. On this ground, the authors suggest, that Chinese government should adopt policies assisting farmers in the transition to organic farming for the sustainable development of China’s organic agriculture. Cooperation of farmers’ cooperatives and research institutions to improve organic farming techniques should also be promoted.

  15. A systems theory approach to career development: Exploring factors that affect science as a career choice

    Science.gov (United States)

    Liskey, Brian K.

    This research project was designed to examine the factors that affect students' choice in a career. Specifically, the factors of (a) achievement, (b) interest, (c) self-efficacy, (d) perceived preparation for a career, and (e) being informed about a career will be under investigation. Of key importance to the study is how these factors can affect a student's perception about choosing a science career. A quantitative analysis of secondary data from the 2006 and 2009 Program for International Student Assessment (PISA) international assessment and attitudinal questionnaire provided data on student perceptions and aptitude in science. The sample from PISA included over 400,000 15 year-old students from 57 countries. From the 57 countries, 30 countries, comprised by Organization for Economic and Cooperative Development (OECD), were isolated for analysis. Within this group of 30, 11 were selected for comparison based on their questionnaire response to expectations for a career in science at age 30. The Institute for Educational Science's, International Data Explorer was utilized to acquire and analyze data from the 2006 and 2009 PISA international tests and questionnaires to determine significance between scaled scores and PISA indices. Variables were chosen as factors affecting student's perception on various systems outlined by the Systems Theory of Career Development (Patton & McMahon, 1997) and the Systems Theory of Career Development Framework (Patton & McMahon, 1999). Four country groups were established based on student responses to question 30a from the 2006 PISA attitudinal questionnaire, which asks what career students expected to have at age 30. The results from comparing country groups showed that countries in Group A, which showed the highest values for students expecting a career in science, also had the highest average values for achievement on the PISA science literacy assessment. Likewise, countries that had the lowest values for expecting a career in

  16. Common and unique associations of adolescents' affective and cognitive empathy development with conflict behavior towards parents.

    Science.gov (United States)

    Van Lissa, Caspar J; Hawk, Skyler T; Branje, Susan; Koot, Hans M; Meeus, Wim H J

    2016-02-01

    Adolescents' development of two empathy dimensions, affective empathic concern and cognitive perspective taking, may be associated with shifts towards more constructive behaviors in conflict with parents. This six-year longitudinal study (ages 13-18) used multivariate latent growth curve modeling to investigate correlations between the developmental trajectories of adolescents' (N = 497) empathic dispositions and trajectories of their conflict behaviors towards both parents. There were some similarities between the associations of both empathy dimensions with conflict behaviors. Both empathy dimensions were associated with reduced conflict escalation with mothers, and increased problem solving with both parents. However, these associations were consistently stronger for perspective taking than for empathic concern. Furthermore, higher levels of compliance with mothers in early adolescence were uniquely associated with over-time increasing empathic concern. Perspective taking was uniquely associated with decreased withdrawal from conflicts. Perspective taking thus appears to be more strongly associated with a pattern of constructive conflict behaviors. PMID:26760479

  17. Susceptible period of socio-emotional development affected by constant exposure to daylight.

    Science.gov (United States)

    Koshiba, Mamiko; Senoo, Aya; Karino, Genta; Ozawa, Simpei; Tanaka, Ikuko; Honda, Yoshiko; Usui, Setsuo; Kodama, Tohru; Mimura, Koki; Nakamura, Shun; Kunikata, Tetsuya; Yamanouchi, Hideo; Tokuno, Hironobu

    2015-04-01

    As a diurnal experimental primate, the common marmoset (Callithrix jacchus) has recently contributed to numerous kinds of studies of neurobiological psychiatry as an essential pre-clinical model. The marmoset matures sexually within one or two years after birth. Thus, we can observe how the primate learns and develops psycho-cognitive functions through experiences in experimental environment for a much shorter period compared to that of humans. Longer daylight exposure may affect psychological development of children. In our research, we focus on raising marmosets under constant daylight from birth until various ages. In order to quantitatively evaluate the development of higher-ordered psychological functions, we designed a system of socio-behavioral tests and multivariate correlation analysis methods based on principal component analysis. With reference to the call and typical body movement expressed during a particular social context, we statistically inferred the emotional features of the subjects. In the current literature, we review our published results showing increased alert behaviors by constant light, and then, attempted to extend our additional analysis to seek age-dependent susceptibility to constant light. We then present the neurobiological mechanisms with reference to previous research reports. The current review suggests possible existence of a susceptible period earlier than three to five month-old in the environment-induced developmental disorder model, supposedly like attention deficit hyperactive disorders (ADHD) or oppositional defiant disorder (ODD). PMID:25305341

  18. Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice.

    Science.gov (United States)

    Hu, Youjia; Jin, Ping; Peng, Jian; Zhang, Xiaojun; Wong, F Susan; Wen, Li

    2016-08-01

    Environmental factors clearly influence the pathogenesis of Type 1 diabetes, an autoimmune disease. We have studied gut microbiota as important environmental agents that could affect the initiation or progression of type 1 diabetes especially in the prenatal period. We used neomycin, targeting mainly Gram negative or vancomycin, targeting mainly Gram positive bacteria, to treat pregnant NOD mothers and to study autoimmune diabetes development in their offspring. Neomycin-treated offspring were protected from diabetes, while vancomycin-treated offspring had accelerated diabetes development, and both antibiotics caused distinctly different shifts in gut microbiota composition compared with the offspring from untreated control mice. Our study demonstrated that neomycin treatment of pregnant mothers leads to generation of immune-tolerogenic antigen-presenting cells (APCs) in the offspring and these APCs had reduced specific autoantigen-presenting function both in vitro and in vivo. Moreover, the protection from diabetes mediated by tolerogenic APCs was vertically transmissible to the second generation. In contrast, more diabetogenic inflammatory T cells were found in the lymphoid organs of the offspring from the vancomycin-treated pregnant mothers. This change however was not transmitted to the second generation. Our results suggested that prenatal exposure to antibiotic influenced gut bacterial composition at the earliest time point in life and is critical for consequent education of the immune system. As different bacteria can induce different immune responses, understanding these differences and how to generate self-tolerogenic APCs could be important for developing new therapy for type 1 diabetes. PMID:27178773

  19. A study of language development and affecting factors in children aged 5 to 27 months.

    Science.gov (United States)

    Muluk, Nuray Bayar; Bayoğlu, Birgül; Anlar, Banu

    2016-01-01

    We conducted a study to assess the factors that affect language development in infants and toddlers using data obtained during developmental screening. Our study group consisted of 505 children-244 (48.3%) boys and 261 (51.7%) girls, aged 5 to 27 months. The children were divided into four age groups: group 1, which we designated as the "6 months" group (age range: 5 to 7 mo); group 2, designated as the "12 months" group (11 to 13 mo); group 3, designated as the "18 months" group (17 to 19 mo); and group 4, designated as the "24 months" group (23 to 27 mo). In addition to demographic data, we compiled data using the Denver II Developmental Screening Test, as well as neurologic examination findings and medical histories. At 6 months, the social item "Works for toy out of reach" was positively related to all language development items. Two gross motor development items-"Pull to sit, no head lag" and "Lifts chest with arm support"-were related to the "Turns to sound" and "Turns to voice" items, respectively. Overall, children whose mothers had higher education levels and who were living in higher socioeconomic areas showed significantly greater language development, as did boys, specifically. At 12 months, higher maternal ages, some gross motor development items, and some social items were related to better language development, and children living in higher socioeconomic areas had a significantly increased ability to pass the "4 words other than mama/dada" item. At 18 months, the ability of girls to pass the "4 words other than mama/dada" item increased, and children who passed the "4 words other than mama/dada" item did not pass the "Throws ball" gross motor item. At 24 months, children whose mothers were older had better "Combines 2 words" and "Speech half intelligible" items, girls had better "Comprehends prepositions (such as under/above)" skills, and boys had better "Shows 4 parts of doll" skills. We conclude that language items appear to change together with

  20. Habitat quality affects early physiology and subsequent neuromotor development of juvenile black-capped chickadees.

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    Thibault Grava

    Full Text Available In songbirds, the ability to learn and render the species-specific song is influenced by the development of both the song nuclei in the brain and the syrinx (bird's vocal apparatus early in the bird's life. In black-capped chickadees (Poecille atricapillus, habitat quality is known to affect song structure, with birds in high-quality habitat (mature forest having a higher song consistency than birds in low-quality habitat (young forest. Although this difference is suspected to stem from differences in development, the developmental status of juvenile birds in either habitat remains unexplored. In this study, we used ptilochronology and feather corticosterone to compare the conditional state of juvenile chickadees in young and mature forest during two distinct periods of song learning - the sensory phase, which occurs prior to settlement, and the sensorimotor phase, which occurs post-settlement. A sample of juvenile males was captured and euthanized several weeks prior to their first breeding season to compare the development of song center nuclei and syrinx in both habitats. The corticosterone levels of natally-grown feathers were greater among birds that settled in mature than young forests - as these feathers were grown pre-settlement, they reflect differences in physiology during the sensory phase. This difference in conditional state is reflected by differences in syrinx and song center nuclei development later during the sensorimotor phase - birds in young forest have smaller syrinx, and moderately-larger RA, than birds in mature forest. Those differences could be responsible for the difference in consistency in song structure observed across habitats. The difference in physiological state across habitats, combined with potential compounding effect of differences in winter resources between habitats, could influence the difference in syrinx and neural development seen in juvenile males during the early spring, and influence the male

  1. How musical training affects cognitive development: rhythm, reward and other modulating variables.

    Science.gov (United States)

    Miendlarzewska, Ewa A; Trost, Wiebke J

    2013-01-01

    Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musical training extend beyond the skills it directly aims to train and last well into adulthood. For example, children who undergo musical training have better verbal memory, second language pronunciation accuracy, reading ability and executive functions. Learning to play an instrument as a child may even predict academic performance and IQ in young adulthood. The degree of observed structural and functional adaptation in the brain correlates with intensity and duration of practice. Importantly, the effects on cognitive development depend on the timing of musical initiation due to sensitive periods during development, as well as on several other modulating variables. Notably, we point to motivation, reward and social context of musical education, which are important yet neglected factors affecting the long-term benefits of musical training. Further, we introduce the notion of rhythmic entrainment and suggest that it may represent a mechanism supporting learning and development of executive functions. It also hones temporal processing and orienting of attention in time that may underlie enhancements observed in reading and verbal memory. We conclude that musical training uniquely engenders near and far transfer effects, preparing a foundation for a range of skills, and thus fostering cognitive development. PMID:24672420

  2. How musical training affects cognitive development: rhythm, reward and other modulating variables.

    Directory of Open Access Journals (Sweden)

    Ewa Aurelia Miendlarzewska

    2014-01-01

    Full Text Available Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musical training extend beyond the skills it directly aims to train and last well into adulthood. For example, children who undergo musical training have better verbal memory, second language pronunciation accuracy, reading ability and executive functions. Learning to play an instrument as a child may even predict academic performance and IQ in young adulthood. The degree of observed structural and functional adaptation in the brain correlates with intensity and duration of practice. Importantly, the effects on cognitive development depend on the timing of musical initiation due to sensitive periods during development, as well as on several other modulating variables. Notably, we point to motivation, reward and social context of musical education, which are important yet neglected factors affecting the long-term benefits of musical training. Further, we introduce the notion of rhythmic entrainment and suggest that it may represent a mechanism supporting learning and development of executive functions. It also hones temporal processing and orienting of attention in time that may underlie enhancements observed in reading and verbal memory. We conclude that musical training uniquely engenders near and far transfer effects, preparing a foundation for a range of skills, and thus fostering cognitive development.

  3. dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development

    International Nuclear Information System (INIS)

    Highlights: • Murine NTDs were successfully induced by means of hydroxyurea (HU). • The impairment of dNTP was induced via inhibition of ribonucleotide reductase. • dNTP deficiency induced by HU caused defective DNA synthesis and repair. • Abnormal apoptosis and proliferation induced by HU affected neural tube development. - Abstract: Exposure to environmental toxic chemicals in utero during the neural tube development period can cause developmental disorders. To evaluate the disruption of neural tube development programming, the murine neural tube defects (NTDs) model was induced by interrupting folate metabolism using methotrexate in our previous study. The present study aimed to examine the effects of dNTP deficiency induced by hydroxyurea (HU), a specific ribonucleotide reductase (RNR) inhibitor, during murine neural tube development. Pregnant C57BL/6J mice were intraperitoneally injected with various doses of HU on gestation day (GD) 7.5, and the embryos were checked on GD 11.5. RNR activity and deoxynucleoside triphosphate (dNTP) levels were measured in the optimal dose. Additionally, DNA damage was examined by comet analysis and terminal deoxynucleotidyl transferase mediated dUTP nick end-labeling (TUNEL) assay. Cellular behaviors in NTDs embryos were evaluated with phosphorylation of histone H3 (PH-3) and caspase-3 using immunohistochemistry and western blot analysis. The results showed that NTDs were observed mostly with HU treatment at an optimal dose of 225 mg/kg b/w. RNR activity was inhibited and dNTP levels were decreased in HU-treated embryos with NTDs. Additionally, increased DNA damage, decreased proliferation, and increased caspase-3 were significant in NTDs embryos compared to the controls. Results indicated that HU induced murine NTDs model by disturbing dNTP metabolism and further led to the abnormal cell balance between proliferation and apoptosis

  4. Malaria parasite diversity and transmission intensity affect development of parasitological immunity in a mathematical model

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    Eckhoff Philip A

    2012-12-01

    Full Text Available Abstract Background The development of parasitological immunity against malaria affects the ability to detect infection, the efficiency of the local human parasite reservoir at infecting mosquitoes, and the response to reintroduction of parasites to previously cleared areas. Observations of similar age-trends in detected prevalence and mean parasitaemia across more than an order-of-magnitude of variation in baseline transmission complicate simple exposure-driven explanations. Methods Mathematical models often employ age-dependent immune factors to match the observed trends, while the present model uses a new detailed mechanistic model of parasite transmission dynamics to explain age-trends through the mechanism of parasite diversity. Illustrative simulations are performed for multiple field sites in Tanzania and Nigeria, and observed age-trends and seasonality in parasite prevalence are recreated in silico, proffering possible mechanistic explanations of the observational data. Results Observed temporal dynamics in measured parasitaemia are recreated for each location and age-prevalence outputs are studied. Increasing population-level diversity in malaria surface antigens delays development of broad parasitological immunity. A local parasite population with high diversity can recreate the observed trends in age-prevalence across more than an order of magnitude of variation in transmission intensities. Conclusions Mechanistic models of human immunity and parasite antigen diversity can recreate the observed temporal patterns for the development of parasitological immunity across a wide range of transmission intensities. This has implications for the distribution of disease burden across the population, the human transmission reservoir, design of elimination campaigns, and development and roll-out of potential vaccines.

  5. Digital Immigrant Teacher Perceptions of Social Media as It Influences the Affective and Cognitive Development of Students: A Phenomenological Study

    Science.gov (United States)

    Williams, Robert Warren

    2012-01-01

    The purpose of this transcendental phenomenological study is to describe how digital immigrant teachers perceive the influence of social media on the affective and cognitive development of students at three high schools in Alabama. As the prevalence of social technologies is increasing, educators must understand how it is affecting students in…

  6. Leading trends in environmental regulation that affect energy development. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Steele, R V; Attaway, L D; Christerson, J A; Kikel, D A; Kuebler, J D; Lupatkin, B M; Liu, C S; Meyer, R; Peyton, T O; Sussin, M H

    1980-01-01

    Major environmental issues that are likely to affect the implementation of energy technologies between now and the year 2000 are identified and assessed. The energy technologies specifically addressed are: oil recovery and processing; gas recovery and processing; coal liquefaction; coal gasification (surface); in situ coal gasification; direct coal combustion; advanced power systems; magnetohydrodynamics; surface oil shale retorting; true and modified in situ oil shale retorting; geothermal energy; biomass energy conversion; and nuclear power (fission). Environmental analyses of these technologies included, in addition to the main processing steps, the complete fuel cycle from resource extraction to end use. A comprehensive survey of the environmental community (including environmental groups, researchers, and regulatory agencies) was carried out in parallel with an analysis of the technologies to identify important future environmental issues. Each of the final 20 issues selected by the project staff has the following common attributes: consensus of the environmental community that the issue is important; it is a likely candidate for future regulatory action; it deals with a major environmental aspect of energy development. The analyses of the 20 major issues address their environmental problem areas, current regulatory status, and the impact of future regulations. These analyses are followed by a quantitative assessment of the impact on energy costs and nationwide pollutant emissions of possible future regulations. This is accomplished by employing the Strategic Environmental Assessment System (SEAS) for a subset of the 20 major issues. The report concludes with a more general discussion of the impact of environmental regulatory action on energy development.

  7. Mosaicism for the FMR1 gene influences adaptive skills development in fragile X-affected males

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, I.L.; Sudhalter, V.; Nolin, S.L. [New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY (United States)

    1996-08-09

    Fragile X syndrome is one of the most common forms of inherited mental retardation, and the first of a new class of genetic disorders associated with expanded trinucleotide repeats. Previously, we found that about 41% of affected males are mosaic for this mutation in that some of their blood cells have an active fragile X gene and others do not. It has been hypothesized that these mosaic cases should show higher levels of functioning than those who have only the inactive full mutation gene, but previous studies have provided negative or equivocal results. In the present study, the cross-sectional development of communication, self-care, socialization, and motor skills was studied in 46 males with fragile X syndrome under age 20 years as a function of two variables: age and the presence or absence of mosaicism. The rate of adaptive skills development was 2-4 times as great in mosaic cases as in full mutation cases. There was also a trend for cases with autism to be more prevalent in the full-mutation group. These results have implications for prognosis, for the utility of gene or protein replacement therapies for this disorder, and for understanding the association between mental retardation, developmental disorders, and fragile X syndrome. 21 refs., 3 figs.

  8. Diurnal temperature variations affect development of a herbivorous arthropod pest and its predators.

    Science.gov (United States)

    Vangansbeke, Dominiek; Audenaert, Joachim; Nguyen, Duc Tung; Verhoeven, Ruth; Gobin, Bruno; Tirry, Luc; De Clercq, Patrick

    2015-01-01

    The impact of daily temperature variations on arthropod life history remains woefully understudied compared to the large body of research that has been carried out on the effects of constant temperatures. However, diurnal varying temperature regimes more commonly represent the environment in which most organisms thrive. Such varying temperature regimes have been demonstrated to substantially affect development and reproduction of ectothermic organisms, generally in accordance with Jensen's inequality. In the present study we evaluated the impact of temperature alternations at 4 amplitudes (DTR0, +5, +10 and +15°C) on the developmental rate of the predatory mites Phytoseiulus persimilis Athias-Henriot and Neoseiulus californicus McGregor (Acari: Phytoseiidae) and their natural prey, the two-spotted spider mite Tetranychus urticae Koch (Acari: Tetranychidae). We have modelled their developmental rates as a function of temperature using both linear and nonlinear models. Diurnally alternating temperatures resulted in a faster development in the lower temperature range as compared to their corresponding mean constant temperatures, whereas the opposite was observed in the higher temperature range. Our results indicate that Jensen's inequality does not suffice to fully explain the differences in developmental rates at constant and alternating temperatures, suggesting additional physiological responses play a role. It is concluded that diurnal temperature range should not be ignored and should be incorporated in predictive models on the phenology of arthropod pests and their natural enemies and their performance in biological control programmes. PMID:25874697

  9. Rearing Tenebrio molitor in BLSS: Dietary fiber affects larval growth, development, and respiration characteristics

    Science.gov (United States)

    Li, Leyuan; Stasiak, Michael; Li, Liang; Xie, Beizhen; Fu, Yuming; Gidzinski, Danuta; Dixon, Mike; Liu, Hong

    2016-01-01

    Rearing of yellow mealworm (Tenebrio molitor L.) will provide good animal nutrition for astronauts in a bioregenerative life support system. In this study, growth and biomass conversion data of T. molitor larvae were tested for calculating the stoichiometric equation of its growth. Result of a respiratory quotient test proved the validity of the equation. Fiber had the most reduction in mass during T. molitor‧s consumption, and thus it is speculated that fiber is an important factor affecting larval growth of T. molitor. In order to further confirm this hypothesis and find out a proper feed fiber content, T. molitor larvae were fed on diets with 4 levels of fiber. Larval growth, development and respiration in each group were compared and analyzed. Results showed that crude-fiber content of 5% had a significant promoting effect on larvae in early instars, and is beneficial for pupa eclosion. When fed on feed of 5-10% crude-fiber, larvae in later instars reached optimal levels in growth, development and respiration. Therefore, we suggest that crude fiber content in feed can be controlled within 5-10%, and with the consideration of food palatability, a crude fiber of 5% is advisable.

  10. States and compacts: Issues and events affecting facility development efforts, including the Barnwell opening

    Energy Technology Data Exchange (ETDEWEB)

    Larson, G.S.

    1995-12-31

    Ten years have passed since the first regional low-level radioactive waste compacts received Congressional consent and initiated their efforts to develop new disposal capacity. During these 10 years, both significant achievements and serious setbacks have marked our efforts and affect our current outlook. Recent events in the waste marketplace, particularly in the operating status of the Barnwell disposal facility, have now raised legitimate questions about the continued rationale for the regional framework that grew out of the original legislation enacted by Congress in 1980. At the same time, licensing activities for new regional disposal facilities are under way in three states, and a fourth awaits the final go-ahead to begin construction. Uncertainty over the meaning and reliability of the marketplace events makes it difficult to gauge long-term implications. In addition, differences in the status of individual state and compact facility development efforts lead to varying assessments of the influence these events will, or should, have on such efforts.

  11. Glycerol affects root development through regulation of multiple pathways in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Jun Hu

    demonstrated that glycerol treatment altered endogenous levels of G3P, phosphate and ROS, affected auxin distribution and cell division in the root meristem, and eventually resulted in modifications of root development.

  12. Glycerol affects root development through regulation of multiple pathways in Arabidopsis.

    Science.gov (United States)

    Hu, Jun; Zhang, Yonghong; Wang, Jinfang; Zhou, Yongming

    2014-01-01

    treatment altered endogenous levels of G3P, phosphate and ROS, affected auxin distribution and cell division in the root meristem, and eventually resulted in modifications of root development. PMID:24465999

  13. The economics of research and development : how research and development capital affects production and markets and is affected by tax incentives

    OpenAIRE

    Shah, Anwar; DEC

    1994-01-01

    Certain themes and findings emerge from the authors analysis of key relationships between research and development (R&D) and other factors. Among them: (1) R&D capital and the structure of production: (a) R&D capital facilitates the mapping of technological possibilities into economic opportunities. (b) R&D takes time to accumulate and uses up scarce resources. The adjustment process from project initiation to product and process development typically takes three to five years. (c) The margin...

  14. Study of major factors to affect photoresist profile on developable bottom anti-reflective coating process

    Science.gov (United States)

    Roh, Hyo Jung; Ju, Dong Kyu; Kim, Hyun Jin; Kim, Jaehyun

    2011-04-01

    As critical dimensions continue to shrink in lithography, new materials will be needed to meet the new demands imposed by this shrinkage. Recently, there are needs for novel materials with various substrates and immersing process, including double patterning process, a high resolution implant process, and so on. Among such materials, Developable Bottom Anti-reflective Coating material (DBARC) is a good candidate for high resolution implant application as well as double patterning. DBARC should have reflectivity control function as an ordinary BARC, as well as an appropriate solubility in TMAH-based conventional developer after exposure and bake process. The most distinguished advantage of DBARC is to skip BARC etch process that is required in normal BARC process. In spite of this advantage, the photoresist profile on DBARC could be influenced by components and process conditions of DBARC. Several groups have tried to solve this issue to implement DBARC to new process. We have studied material-related factors affecting photoresist profiles, such as a polymer, photo-acid generators (PAGs), and additives. And we explored the effect of process condition for photoresist and DBARC. In case of polymer, we studied the effect of dissolution rate in developer and crosslinking functionality. For PAGs and additives, the effect of acid diffusivity and cross-linking degree according to their bulkiness were examined. We also evaluated coated film stability in a photoresist solvent after BARC bake process and compared lithographic performance of various DBARC formulations. In addition, the effect of photoresist profile with bake condition of photoresist and DBARC were investigated. In this paper, we will demonstrate the most influential factors of DBARC to photoresist profile and suggest the optimum formulation and process condition for DBARC application.

  15. Genes of the most conserved WOX clade in plants affect root and flower development in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Moreau Hervé

    2008-10-01

    Full Text Available Abstract Background The Wuschel related homeobox (WOX family proteins are key regulators implicated in the determination of cell fate in plants by preventing cell differentiation. A recent WOX phylogeny, based on WOX homeodomains, showed that all of the Physcomitrella patens and Selaginella moellendorffii WOX proteins clustered into a single orthologous group. We hypothesized that members of this group might preferentially share a significant part of their function in phylogenetically distant organisms. Hence, we first validated the limits of the WOX13 orthologous group (WOX13 OG using the occurrence of other clade specific signatures and conserved intron insertion sites. Secondly, a functional analysis using expression data and mutants was undertaken. Results The WOX13 OG contained the most conserved plant WOX proteins including the only WOX detected in the highly proliferating basal unicellular and photosynthetic organism Ostreococcus tauri. A large expansion of the WOX family was observed after the separation of mosses from other land plants and before monocots and dicots have arisen. In Arabidopsis thaliana, AtWOX13 was dynamically expressed during primary and lateral root initiation and development, in gynoecium and during embryo development. AtWOX13 appeared to affect the floral transition. An intriguing clade, represented by the functional AtWOX14 gene inside the WOX13 OG, was only found in the Brassicaceae. Compared to AtWOX13, the gene expression profile of AtWOX14 was restricted to the early stages of lateral root formation and specific to developing anthers. A mutational insertion upstream of the AtWOX14 homeodomain sequence led to abnormal root development, a delay in the floral transition and premature anther differentiation. Conclusion Our data provide evidence in favor of the WOX13 OG as the clade containing the most conserved WOX genes and established a functional link to organ initiation and development in Arabidopsis, most

  16. Ozone affects growth and development of Pieris brassicae on the wild host plant Brassica nigra

    International Nuclear Information System (INIS)

    When plants are exposed to ozone they exhibit changes in both primary and secondary metabolism, which may affect their interactions with herbivorous insects. Here we investigated the performance and preferences of the specialist herbivore Pieris brassicae on the wild plant Brassica nigra under elevated ozone conditions. The direct and indirect effects of ozone on the plant-herbivore system were studied. In both cases ozone exposure had a negative effect on P. brassicae development. However, in dual-choice tests larvae preferentially consumed plant material previously fumigated with the highest concentration tested, showing a lack of correlation between larval preference and performance on ozone exposed plants. Metabolomic analysis of leaf material subjected to combinations of ozone and herbivore-feeding, and focussing on known defence metabolites, indicated that P. brassicae behaviour and performance were associated with ozone-induced alterations to glucosinolate and phenolic pools. - Highlights: • We examined the effects of ozone on Pieris brassicae performance and preference. • We studied ozone and herbivore induced changes in the metabolome of Brassica nigra. • The performance of P. brassicae did not correlate with preference of ozonated plants. • Ozone and herbivore-feeding stress changes the phytochemical pools of B. nigra. - Ozone indirectly reduces herbivore performance, which is associated with change in phytochemical pools, but does not correlate with host plant preference

  17. Selected Factors Affecting the Development of Auditing Services Market in Poland

    Directory of Open Access Journals (Sweden)

    Rafał Rydzak

    2010-12-01

    Full Text Available This article presents three factors affecting the development of auditing services market and its oligopoly. The binding provisions of law concerning discretionary powers of auditing companies’ proprietary rights, to some extent, petrify the current auditing market structure. By means of numerous capital access deterrents they make it impossible to compete with the most influential entities on the market. Bearing in mind the vital influence of statutory auditors on companies’ functioning, and allowing the companies access to capital, it is advisable to abolish all binding restrictions and simultaneously strengthen the internal control mechanisms facilitating high quality of financial review and statutory auditors’ independence. The auditing services market is, most of all, subject to price competition. The binding requisition of statutory auditors’ (including auditing companies salary disclosure intensifies mutual chain of audit pricing dependence and restricts competition. Properly utilized rotation principle, by strengthening the competence, might positively influence functioning of the auditing services market. It increases an opportunity of collaborating with new entities, while enforcing constant improvement of qualifications required to perform financial reviews. Hence its wider use should be postulated.

  18. A comparative study of central corneal thickness (CCT and intraocular pressure (IOP in University of KwaZulu-Natal students of Black and Indian ethnicity*

    Directory of Open Access Journals (Sweden)

    Z. Sardiwalla

    2012-12-01

    Full Text Available Thisstudy compared central corneal thickness (CCT and intraocular pressure (IOP of Black and Indian students from the University of Kwa-Zulu-Natal. Two hundred (100 Black and 100 Indi-an participants of both genders aged 18-25 years (mean and standard deviation; 20.1±1.6 years participated in this study. CCT and IOP were measured for the right eye of each participant using a Tono-Pachymeter (NT530P and a Goldmann applanation tonometer (GAT respectively. Data was analyzed with descriptive, t-test and Pearson’s cor-relation statistics. In the total sample (N = 200, the mean CCT value was 519.5 ± 38.6 μm and CCT was higher in the Indians (526.5 ± 37.2 µm than in the Blacks (512.4 ± 38.9 µm (p = 0.01.  Also, it was higher in the females (522.3 µm than in males (516.7 µm, but the difference was insignificant (p = 0.07. The mean CCT was higher in the Indian males (520.1 µm than in the Black males (513.2 µm, but the difference was insignificant (p=0.39.  However, it was significantly higher in the Indian females (533 µm than in the Black females (511.6 µm (p = 0.003. In the total sample, the mean IOP was 14.6 mmHg and IOP was greater in Indiansthan Blacks (mean = 15.3 ± 2.9 mmHg and 13.8 ± 2.6 mmHg respectively (p = 0.01. Also, the mean IOP (N = 200 value was slightly higher in the females (14.7 mmHg than in males (14.5 mmHg (p = 0.51. The mean IOP was higher in the Indian males (15.0 mmHg than in the Black males (14.0 mmHg (p = 0.07 and the mean IOP value was higher in the Indian females (15.7 mmHg than in the Black females (13.6 mmHg (p < 0.001. The higher mean IOP value in the Indian than Black participants was attributed to the higher mean CCT values. A positive, but inconsistent association between CCT and IOP was found in this study, the coefficient in the total sample (r = 0.382, p = 0.000, in the Blacks (r = 0.196, p = 0.05 and in Indians (r = 0.498, p = 0.000. A national population study comparing CCT and IOP in the various

  19. GroEL and CCT are catalytic unfoldases mediating out-of-cage polypeptide refolding without ATP.

    Science.gov (United States)

    Priya, Smriti; Sharma, Sandeep Kumar; Sood, Vishal; Mattoo, Rayees U H; Finka, Andrija; Azem, Abdussalam; De Los Rios, Paolo; Goloubinoff, Pierre

    2013-04-30

    Chaperonins are cage-like complexes in which nonnative polypeptides prone to aggregation are thought to reach their native state optimally. However, they also may use ATP to unfold stably bound misfolded polypeptides and mediate the out-of-cage native refolding of large proteins. Here, we show that even without ATP and GroES, both GroEL and the eukaryotic chaperonin containing t-complex polypeptide 1 (CCT/TRiC) can unfold stable misfolded polypeptide conformers and readily release them from the access ways to the cage. Reconciling earlier disparate experimental observations to ours, we present a comprehensive model whereby following unfolding on the upper cavity, in-cage confinement is not needed for the released intermediates to slowly reach their native state in solution. As over-sticky intermediates occasionally stall the catalytic unfoldase sites, GroES mobile loops and ATP are necessary to dissociate the inhibitory species and regenerate the unfolding activity. Thus, chaperonin rings are not obligate confining antiaggregation cages. They are polypeptide unfoldases that can iteratively convert stable off-pathway conformers into functional proteins. PMID:23584019

  20. From a Perspective on Foreign Language Learning Anxiety to Develop an Affective Tutoring System

    Science.gov (United States)

    Lin, Hao-Chiang Koong; Chao, Ching-Ju; Huang, Tsu-Ching

    2015-01-01

    According to Krashen's affective filter hypothesis, students who are highly motivated have their self-consciousness. When they enter a learning context with a low level of anxiety, they are much more likely to become successful language acquirers than those who do not. Affective factors such as motivation, attitude, and anxiety, have a direct…

  1. Factors Affecting Malnutrition in Developing Countries: A Linear Mixed Model Approach

    Directory of Open Access Journals (Sweden)

    Sohair F. Higazi

    2012-11-01

    Full Text Available  AbstractThe main objective of this study is to pinpoint the main factors that affect the percentage who suffers of malnutrition in developing countries. Three locations are randomly chosen: Asia, Africa, and Middle east and North Africa ( MENA; A total of 96 countries were chosen randomly from 137  developing countries of the three locations; and were cross classified by " Location" and  " Human Development Index (HDI as high, middle, and low (UNDP,  2005.  Data for the study was compiled from FAO (2005. The analysis started with seven explanatory variables and the dependent variable; however, stepwise regression reveals that the average Protein intake and Infant mortality rate were the only two significant variables. "Location and "HDI" are dummy coded and OLS regression is performed using the two significant variables, but the only significant variable was the "average protein intake". OLS multiple regression Model is re-applied to the data using dummy variables technique with interaction with the "average Protein intake", nine regression equations were reached.The Linear Mixed effect Models are also applied, using "location" as the random factor and "HDI" as the fixed factor. Five models were applied: (1 a null model (baseline modelwhere no predictors are introduced to the model; (2 the fixed model: where predictors used are the  covariate and the HDI; (3 the random model: where predictors used are  the covariate and Location ; (4 the mixed model: where predictors used are the covariate and the HDI I  ( fixed and the location( random; and (5 the random coefficient model: where predictors used are  the covariate ,  the HDI Index  and the location but produces different prediction equations that differ in slopes and intercepts. Models are compared based on information criterions. The random coefficient model produces the least criterion values and thus fits better than all previous ones. A comparison between the Random Coefficient

  2. Development of a multiplex real time PCR to differentiate Sarcocystis spp. affecting cattle.

    Science.gov (United States)

    Moré, Gastón; Schares, Susann; Maksimov, Aline; Conraths, Franz J; Venturini, María C; Schares, Gereon

    2013-10-18

    Cattle are intermediate hosts of Sarcocystis cruzi, Sarcocystis hirsuta and Sarcocystis hominis which use canids, felids or primates as definitive hosts (DH), respectively, and in addition of Sarcocystis sinensis from which the DH is unknown. The aims of the present study were to develop and optimize a multiplex real time PCR for a sensitive and specific differentiation of Sarcocystis spp. affecting cattle and to estimate the prevalence of Sarcocystis spp. in Argentinean cattle. The 18S rRNA genes from individual sarcocysts were amplified and cloned to serve as controls. For the amplification of bovine Sarcocystis spp. a total of 3 primers were used in combination with specific individual probes. Each assay was evaluated and optimized individually and subsequently combined in a multiplex assay (BovSarcoMultiplex real time PCR). The analytical specificity of the multiplex assay was assessed using 5 ng of DNA of heterologous Sarcocystis spp. and other apicomplexan parasites, and no positive reactions were observed other than for the species the PCR targeted. The analytical sensitivity ranged between 0.0125 and 0.125 fg of plasmid DNA (equivalent to the DNA of 2-20 plasmid DNA copies) or resembling DNA of 0.1-0.3 bradyzoites. A total of 380 DNA loin samples from Argentina were tested and 313, 29, 14 and 2 were positive for S. cruzi, S. sinensis, S. hirsuta and S. hominis, respectively. S. sinensis was the most prevalent species among thick walled Sarcocystis spp. in Argentinean cattle. Mixed infections were detected in 8.9% of all samples. Diagnostic sensitivity and specificity for the BovSarcoMultiplex real time PCR relative to previous microscopic examination for thin and thick-walled cyst were 91.5% and 41.7%, 36.3% and 95.9% respectively. Improved DNA extraction methods may allow to further increase the specific and sensitive detection of Sarcocystis spp. in meat samples. PMID:23680541

  3. Chronic Exposure to Ambient Levels of Urban Particles Affects Mouse Lung Development

    Science.gov (United States)

    Mauad, Thais; Rivero, Dolores Helena Rodriguez Ferreira; de Oliveira, Regiani Carvalho; de Faria Coimbra Lichtenfels, Ana Julia; Guimarães, Eliane Tigre; de Andre, Paulo Afonso; Kasahara, David Itiro; de Siqueira Bueno, Heloisa Maria; Saldiva, Paulo Hilário Nascimento

    2008-01-01

    Rationale: Chronic exposure to air pollution has been associated with adverse effects on children's lung growth. Objectives: We analyzed the effects of chronic exposure to urban levels of particulate matter (PM) on selected phases of mouse lung development. Methods: The exposure occurred in two open-top chambers (filtered and nonfiltered) placed 20 m from a street with heavy traffic in São Paulo, 24 hours/day for 8 months. There was a significant reduction of the levels of PM2.5 inside the filtered chamber (filtered = 2.9 ± 3.0 μg/m3, nonfiltered = 16.8 ± 8.3 μg/m3; P = 0.001). At this exposure site, vehicular sources are the major components of PM2.5 (PM ≤ 2.5μm). Exposure of the parental generation in the two chambers occurred from the 10th to the 120th days of life. After mating and birth of offspring, a crossover of mothers and pups occurred within the chambers, resulting in four groups of pups: nonexposed, prenatal, postnatal, and pre+postnatal. Offspring were killed at the age of 15 (n = 42) and 90 (n = 35) days; lungs were analyzed by morphometry for surface to volume ratio (as an estimator of alveolization). Pressure–volume curves were performed in the older groups, using a 20-ml plethysmograph. Measurements and Main Results: Mice exposed to PM2.5 pre+postnatally presented a smaller surface to volume ratio when compared with nonexposed animals (P = 0.036). The pre+postnatal group presented reduced inspiratory and expiratory volumes at higher levels of transpulmonary pressure (P = 0.001). There were no differences among prenatal and postnatal exposure and nonexposed animals. Conclusions: Our data provide anatomical and functional support to the concept that chronic exposure to urban PM affects lung growth. PMID:18596224

  4. On the Strategies of Helping Students Develop Positive Affections in FLT

    Institute of Scientific and Technical Information of China (English)

    Mofang Cheng

    2010-01-01

    Former language experts and education practitioners have explored a lot as to the handing of affective factors in foreign language teaching and learning. Based on their achievements and also the observation,investigation and practice of the present author,several strategies of helping learners overcome negative affects and construct positive ones in foreign language learning and teaching will be put forward,with the guidance of principles formulated in this essay,which is very helpful to our teachers.

  5. Development of an Instrument to Measure Perceived Cognitive, Affective, and Psychomotor Learning in Traditional and Virtual Classroom Higher Education Settings

    Science.gov (United States)

    Rovai, Alfred P.; Wighting, Mervyn J.; Baker, Jason D.; Grooms, Linda D.

    2009-01-01

    The purpose of this study was to develop and validate a self-report instrument that can be used to measure learning in the cognitive, affective, and psychomotor domains. The study underwent three phases, each with its own data collection and analysis. Phase I featured the development, testing, and factor analysis of an 80-item instrument that…

  6. Nomothetic outcome assessment in counseling and psychotherapy: Development and preliminary psychometric analyses of the Depression/Anxiety Negative Affect Scale

    OpenAIRE

    Scott T. Meier

    2012-01-01

    Negative affect (NA) plays a significant role in the initiation, persistence, and response to psychotherapy of many client problems (Moses & Barlow, 2006). This report describes the development of a brief NA measure, the Depression/Anxiety Negative Affect (DANA) scale, and preliminary analyses of its psychometric properties. An initial pool of DANA items was selected on the basis of a review of relevant literature about emotion science and counseling outcomes, related tests, and feedback from...

  7. Early Childhood IQ Trajectories in Individuals Later Developing Schizophrenia and Affective Psychoses in the New England Family Studies

    OpenAIRE

    Agnew-Blais, Jessica C.; Buka, Stephen L.; Fitzmaurice, Garrett M.; Smoller, Jordan W.; Goldstein, Jill M.; Seidman, Larry J.

    2015-01-01

    Individuals who develop schizophrenia in adulthood exhibit, on average, deficits in childhood cognition relative to healthy controls. However, it remains unclear when in childhood such deficits emerge and whether they are stable across childhood or change (increase or decrease) across development. Importantly, whether the trajectory of childhood cognition differs among youth who later develop affective psychoses (AP) vs schizophrenia as adults remains unresolved. Subjects in the Collaborative...

  8. Clean coal technology III (CCT III): 10 MW demonstration of gas suspension absorption

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    This project will be the first North American demonstration of the Gas Suspension Absorption (GSA) System in its application for flue gas desulfurization. The purpose of this project is to demonstrate the high sulfur dioxide (SO{sub 2}) removal efficiency as well as the cost effectiveness of the GSA system. GSA is a novel concept for flue gas desulfurization developed by F.L. Smidth miljo (FLS miljo). The GSA system is distinguished in the European market by its low capital cost, high SO{sub 2} removal efficiency and low operating cost. The specific technical objectives of the GSA demonstration project are to: effectively demonstrate SO{sub 2} removal in excess of 90% using high sulfur US coal. Optimize recycle and design parameters to increase efficiencies of lime reagent utilization and SO{sub 2} removal. Compare removal efficiency and cost with existing Spray Dryer/Electrostatic Precipitator technology.

  9. Enhanced Geothermal Systems Research and Development: Models of Subsurface Chemical Processes Affecting Fluid Flow

    Energy Technology Data Exchange (ETDEWEB)

    Moller, Nancy; Weare J. H.

    2008-05-29

    Successful exploitation of the vast amount of heat stored beneath the earth’s surface in hydrothermal and fluid-limited, low permeability geothermal resources would greatly expand the Nation’s domestic energy inventory and thereby promote a more secure energy supply, a stronger economy and a cleaner environment. However, a major factor limiting the expanded development of current hydrothermal resources as well as the production of enhanced geothermal systems (EGS) is insufficient knowledge about the chemical processes controlling subsurface fluid flow. With funding from past grants from the DOE geothermal program and other agencies, we successfully developed advanced equation of state (EOS) and simulation technologies that accurately describe the chemistry of geothermal reservoirs and energy production processes via their free energies for wide XTP ranges. Using the specific interaction equations of Pitzer, we showed that our TEQUIL chemical models can correctly simulate behavior (e.g., mineral scaling and saturation ratios, gas break out, brine mixing effects, down hole temperatures and fluid chemical composition, spent brine incompatibilities) within the compositional range (Na-K-Ca-Cl-SO4-CO3-H2O-SiO2-CO2(g)) and temperature range (T < 350°C) associated with many current geothermal energy production sites that produce brines with temperatures below the critical point of water. The goal of research carried out under DOE grant DE-FG36-04GO14300 (10/1/2004-12/31/2007) was to expand the compositional range of our Pitzer-based TEQUIL fluid/rock interaction models to include the important aluminum and silica interactions (T < 350°C). Aluminum is the third most abundant element in the earth’s crust; and, as a constituent of aluminosilicate minerals, it is found in two thirds of the minerals in the earth’s crust. The ability to accurately characterize effects of temperature, fluid mixing and interactions between major rock-forming minerals and hydrothermal and

  10. NaCl salinity affects lateral root development in Plantago maritima

    NARCIS (Netherlands)

    Rubinigg, M; Wenisch, J; Elzenga, JTM; Stulen, [No Value

    2004-01-01

    Root growth and morphology were assessed weekly in hydroponically-grown seedlings of the halophyte Plantago maritima L. during exposure to 0, 50, 100 and 200 mM NaCl for 21 d. Relative growth rate was reduced by 25% at 200 mM NaCl. The lower NaCl treatments did not affect relative growth rates. Prim

  11. Examining the Familial Link between Positive Affect and Empathy Development in the Second Year

    Science.gov (United States)

    Volbrecht, Michele M.; Lemery-Chalfant, Kathryn; Aksan, Nazan; Zahn-Waxler, Carolyn; Goldsmith, H. Hill

    2007-01-01

    Within a sample of 584 twins aged 12 to 25 months (292 pairs) studied longitudinally, positive affect measured through two laboratory pleasure episodes and maternal report at 12 and 22 months significantly predicted empathy-related helping and hypothesis testing assessed between 19 and 25 months. Girls showed significantly more concern than did…

  12. Complementary expertise in a zoo educator professional development event contributes to the construction of understandings of affective transformation

    Science.gov (United States)

    Kelly, Lisa-Anne DeGregoria; Kassing, Sharon

    2013-09-01

    Cultural Historical Activity Theory served as the analytical framework for the study of a professional development event for a zoo's education department, specifically designed to build understandings of "Affective Transformation," an element pertinent to the organization's strategic plan. Three key products—an Affective Transformation model, scaffolding schematic, and definition, "providing emotional experiences for visitors which increase caring for animals and nature that may lead to zoo-related nature-protective behaviors"—emerged as a result of ongoing deliberation among professional development community members over two days. Participants, including both management- and non-management-level staff, as well as an expert facilitator, contributed complementary expertise to the process. The discussions, therefore, crossed both vertical and horizontal layers of authority. Moreover, leadership was distributed across these levels in the development of these products. Members used pre-existing resources, as well as tools created in the course of the professional development event. Interactions among participants and resources were instrumental in Affective Transformation product development. Examination of one zoo's construction of understanding of affective goals, therefore, may offer insights to other organizations with similar aspirations.

  13. Experimental exposure to urban and pink noise affects brain development and song learning in zebra finches (Taenopygia guttata)

    Science.gov (United States)

    Curcio, Michael T.; Swaddle, John P.; MacDougall-Shackleton, Scott A.

    2016-01-01

    Recently, numerous studies have observed changes in bird vocalizations—especially song—in urban habitats. These changes are often interpreted as adaptive, since they increase the active space of the signal in its environment. However, the proximate mechanisms driving cross-generational changes in song are still unknown. We performed a captive experiment to identify whether noise experienced during development affects song learning and the development of song-control brain regions. Zebra finches (Taeniopygia guttata) were bred while exposed, or not exposed, to recorded traffic urban noise (Study 1) or pink noise (Study 2). We recorded the songs of male offspring and compared these to fathers’ songs. We also measured baseline corticosterone and measured the size of song-control brain regions when the males reached adulthood (Study 1 only). While male zebra finches tended to copy syllables accurately from tutors regardless of noise environment, syntax (the ordering of syllables within songs) was incorrectly copied affected by juveniles exposed to noise. Noise did not affect baseline corticosterone, but did affect the size of brain regions associated with song learning: these regions were smaller in males that had been had been exposed to recorded traffic urban noise in early development. These findings provide a possible mechanism by which noise affects behaviour, leading to potential population differences between wild animals occupying noisier urban environments compared with those in quieter habitats.

  14. Development of the Teacher Candidates’ Level of being Affected from Public Personnel Selection Examination Scale

    Directory of Open Access Journals (Sweden)

    Fatma SUSAR KIRMIZI

    2015-07-01

    Full Text Available This study aimed to develop a scale to evaluate teacher candidates' level of being affected from the public personnel selection examination. The participants of the study consisted of the final year students at Pamukkale University Education Faculty. The participants were 207 teacher candidates, of whom 143 were female and 64 were male. The validity and reliability study of the scale was conducted on the data gathered from teacher candidates studying at Art Teaching, Music Teaching, Turkish Language Teaching, Social Studies Education, Science Teaching, Psychological Counseling and Guidance Education, Elementary Education and Preschool Education departments of Pamukkale University Education Faculty. The Lawshe technique was used in the evaluation of the scale by experts. To determine the construct validity, factor analysis was performed on the data, and two sub-scales were identified. The factor loading values of the items in the first sub-scale ranged between 0,65 and 0,35, and those in the second sub-scale between 0,75 and 0,39. As a result of the analyses, the "Teacher Candidates' Level of Being Affected From Public Personnel Selection Examination Scale" (TCLBAPPSES including 33 items, 23 negative and 10 positive, and two sub-scales was produced. The Cronbach's Alpha reliability coefficient was found as 0,86 for the first sub-dimension, 0,73 for the second sub-dimension, and 0,91 for the whole scale. As a result, it can be argued that the scale is reliable.-------------Öğretmen Adaylarının Kamu Personeli Seçme Sınavından Etkilenme Düzeyi Ölçeğinin GeliştirilmesiÖzet:Bu çalışmada, öğretmen adaylarının kamu personeli seçme sınavından etkilenme düzeylerini değerlendirmek için bir ölçek geliştirilmesi amaçlanmıştır. Araştırmanın çalışma grubunu Pamukkale Üniversitesi Eğitim Fakültesi son sınıf öğrencileri oluşturmuştur. Araştırmada 143 kız, 64 erkek olmak üzere toplam 207 öğretmen adayına ula

  15. Does Inflammation after Stroke Affect the Developing Brain Differently than Adult Brain?

    OpenAIRE

    Vexler, Zinaida S.; Yenari, Midori A.

    2009-01-01

    The immature brain is prone to hypoxic-ischemic encephalopathy and stroke. The incidence of arterial stroke in newborns is similar to that in the elderly. However, the pathogenesis of ischemic brain injury is profoundly affected by age at the time of the insult. Necrosis is a dominant type of neuronal cell death in adult brain, whereas widespread neuronal apoptosis is unique for the early postnatal synaptogenesis period. The inflammatory response, in conjunction with excitotoxic and oxidative...

  16. Examining the Familial Link Between Positive Affect and Empathy Development in the Second Year

    OpenAIRE

    Volbrecht, Michele M.; Lemery-Chalfant, Kathryn; Aksan, Nazan; Zahn-Waxler, Carolyn; Goldsmith, H. Hill

    2007-01-01

    Within a sample of 584 twins aged 12 to 25 months (292 pairs) studied longitudinally, positive affect measured through two laboratory pleasure episodes and maternal report at 12 and 22 months significantly predicted empathy-related helping and hypothesis testing assessed between 19 and 25 months. Girls showed significantly more concern than did boys, whereas boys engaged in hypothesis testing significantly more than did girls. Behavior-genetic analyses indicated substantial shared environment...

  17. Deep Impact: How a Job-Embedded Formative Assessment Professional Development Model Affected Teacher Practice

    Directory of Open Access Journals (Sweden)

    Thomas A. Stewart

    2014-02-01

    Full Text Available This study supports the work of Black and Wiliam (1998, who demonstrated that when teachers effectively utilize formative assessment strategies, student learning increases significantly. However, the researchers also found a “poverty of practice” among teachers, in that few fully understood how to implement classroom formative assessment. This qualitative case study examined a series of voluntary workshops offered at one middle school designed to address this poverty of practice. Data were gathered via semi-structured interviews. These research questions framed the study: (1 What role did a professional learning community structure play in shaping workshop participants’ perceived effectiveness of a voluntary formative assessment initiative? (2 How did this initiative affect workshop participants’ perceptions of their knowledge of formative assessment and differentiation strategies? (3 How did it affect workshop participants’ perceptions of their abilities to teach others about formative assessment and differentiated instruction? (4 How did it affect school-wide use of classroom-level strategies? Results indicated that teacher workshop participants experienced a growth in their capacity to use and teach others various formative assessment strategies, and even non-participating teachers reported greater use of formative assessment in their own instruction. Workshop participants and non-participating teachers perceived little growth in the area of differentiation of instruction, which contradicted some administrator perceptions.

  18. Diversity and Moral Reasoning: How Negative Diverse Peer Interactions Affect the Development of Moral Reasoning in Undergraduate Students

    Science.gov (United States)

    Mayhew, Matthew J.; Engberg, Mark E.

    2010-01-01

    How do interactions with diverse peers affect moral reasoning development? Results from a longitudinal study of 171 students enrolled in an Intergroup Dialogue or Introduction to Sociology course indicate that students who experience more negative interactions with diverse peers report lower developmental gains in moral reasoning, although the…

  19. Eukaryotic release factor 1-2 affects Arabidopsis responses to glucose and phytohormones during germination and early seedling development

    Science.gov (United States)

    Germination and early seedling development are coordinately regulated by glucose and phytohormones such as ABA, GA and ethylene. However, the molecules that affect plant responses to glucose and phytohormones remain to be fully elucidated. Eukaryotic release factor 1 (eRF1) is responsible for recogn...

  20. Complementary Expertise in a Zoo Educator Professional Development Event Contributes to the Construction of Understandings of Affective Transformation

    Science.gov (United States)

    Kelly, Lisa-Anne DeGregoria; Kassing, Sharon

    2013-01-01

    Cultural Historical Activity Theory served as the analytical framework for the study of a professional development event for a zoo's education department, specifically designed to build understandings of "Affective Transformation," an element pertinent to the organization's strategic plan. Three key products--an Affective…

  1. How might climate change affect economic growth in developing countries ? a review of the growth literature with a climate lens

    OpenAIRE

    Lecocq, Franck; Shalizi, Zmarak

    2007-01-01

    This paper reviews the empirical and theoretical literature on economic growth to examine how the four components of the climate change bill, namely mitigation, proactive (ex ante) adaptation, reactive (ex post) adaptation, and ultimate damages of climate change affect growth, especially in developing countries. The authors consider successively the Cass-Koopmans growth model and three maj...

  2. Social environmental factors in Japan affecting the development of proper eating behaviors.

    Science.gov (United States)

    Sasaki, H; Benkert, K; Takeuchi, H; Hagiwara, N; Sasaki, K; Kanemoto, H

    1999-11-01

    This article summarizes issues related to myofunctional disorders/dysphagia and focuses upon social and economic changes within Japanese culture affecting eating habits and behaviors in children. The authors suggest that unfavorable environmental factors negatively impact upon the acquisition of mastication and swallowing behaviors. The article includes discussion of prior research. Studies indicate that decreased observation of early childhood eating habits, dietary changes with regard to higher consumption of fast food and changes within the family, i.e. busy work schedules, decrease in family mealtimes, combine to incur negative change with regard to orofacial function. PMID:10863452

  3. Kinetics, stoichiometry, and anion selectivity of cAMP-stimulated Cl-HCO3 exchange in rabbit cortical collecting tubule (CCT)

    International Nuclear Information System (INIS)

    Cyclic AMP stimulates net HCO3 secretion in rabbit CCT (Schuster, JCI 75:2056). Because cAMP induces Cl-independent (electrogenic) HCO3 secretion in several epithelia, I studied the anion dependence of the CCT cAMP effect. Tubules were perfused in vitro with lumen amiloride; bath cAMP was continuously present to stimulate HCO3 secretion. First, the dependence of HCO3 secretion on lumen [Cl] was determined. With bath [Cl]=O mM, perfusate [Cl] was varied (2-150 mM, gluconate substitution). Mean lumen [Cl] was determined either by a silver electrode in the collected fluid (2-12 mM perfusate) or by 36Cl (12-150 mM). Total bath-to-lumen HCO3 flux, J/sup Ib//sub HCO3/, was measured (bath HCO3=25 mM, perfusate HCO3=O), Passive J/sub HCO3/ was estimated from the GHK equation using a previously-determined HCO3 permeability = 1.9 x 10-6 cm/s. Mediated J/sub HCO3/ vs. mean lumen [Cl] showed saturation kinetics, apparent K/sub m/ = 5.8 mM and V/sub max/ = 8.7 pmol/mm/min. Second, the stoichiometry was estimated. When bath HCO3 was replaced by HEPES at various perfusate [Cl] (12-150 mM), ΔJ/sub HCO3/ varied linearly with ΔJ/sup Ib/sub Cl/ (slope = .85 +- .27). Third, in anion selectivity studies Br supported HCO3 secretion (89% rate with Cl) but I- and SO4/sup =/ did not. In rabbit CCT, as opposed to several other HCO3-secreting epithelia, cAMP stimulates 1:1 Cl-HCO3 exchange

  4. HOW DOES FOREIGN DIRECT INVESTMENT AFFECT GROWTH IN DEVELOPING COUNTRIES? AN EMPIRICAL INVESTIGATION

    OpenAIRE

    E. M. Ekanayake; John R. Ledgerwood

    2010-01-01

    This paper analyzes the effects of foreign direct investment on the economic growth of developing countries. The study uses annual data on a group of 85 developing countries covering Asia, Africa, and Latin America and the Caribbean for the period 1980-2007. We explore the hypothesis that foreign direct investment can promote growth in developing countries. We test this hypothesis using panel data series for foreign direct investment, while accounting for regional differences in Asian, Africa...

  5. Glycerol Affects Root Development through Regulation of Multiple Pathways in Arabidopsis

    OpenAIRE

    Jun Hu; Yonghong Zhang; Jinfang Wang; Yongming Zhou

    2014-01-01

    Glycerol metabolism has been well studied biochemically. However, the means by which glycerol functions in plant development is not well understood. This study aimed to investigate the mechanism underlying the effects of glycerol on root development in Arabidopsis thaliana. Exogenous glycerol inhibited primary root growth and altered lateral root development in wild-type plants. These phenotypes appeared concurrently with increased endogenous glycerol-3-phosphate (G3P) and H2O2 contents in se...

  6. Affect of Early Life Oxygen Exposure on Proper Lung Development and Response to Respiratory Viral Infections

    OpenAIRE

    Domm, William; Misra, Ravi S.; O’Reilly, Michael A.

    2015-01-01

    Children born preterm often exhibit reduced lung function and increased severity of response to respiratory viruses, suggesting that premature birth has compromised proper development of the respiratory epithelium and innate immune defenses. Increasing evidence suggests that premature birth promotes aberrant lung development likely due to the neonatal oxygen transition occurring before pulmonary development has matured. Given that preterm infants are born at a point of time where their immune...

  7. Market oriented new product development: How can a means-end chain approach affect the process?

    DEFF Research Database (Denmark)

    Søndergaard, Helle Alsted

    Few disagree on the advantage of market oriented product development. However, can a well-known theory on consumer behaviour be used as a catalyst for achieving it? This paper describes a case study where means-end chain (MEC) approach was introduced to a cross-functional development team at two...... different stages of the development process. Results show that MEC data is perceived as a good way of gaining knowledge about consumers; that the information serves well as the basis of discussions and for keeping project goals fixed. The results also indicate that MEC data are most valuable to the team in...... the early stages of development process....

  8. A comparative study of the width of the anterior interhemispheric fissure in schizophrenia and senile dementia by cranial computed tomography (CCT)

    International Nuclear Information System (INIS)

    CCT pictures were used to obtain comparative measurements of morphologic changes in the prefrontal lobes in schizophrenics and senile dementia patients as well as in an age-matched control group. A Statistically significant widening of the distance between the inner surfaces of both superior frontal gyri and between anterior surfaces of both cingulate gyri were noted in the diseased group. As to the schizophrenic group, a greater distance between the inner surfaces of both frontal gyri was noted, while a generalized atrophic change of frontal lobes was rather common in the senile dementia group. (author)

  9. Comparative study for toxic elements determination in air particulate reference material by INAA, CCT-ICP-MS, and ICP-MS

    International Nuclear Information System (INIS)

    Although toxic elements are minor components in the atmospheric environment, they play a significant role as important marker for atmospheric science such as risk assessment, long-range transfer study, and source apportionment. Therefore, the techniques, which allow accurate and fast elemental analysis with a minimum pre-treatment, are very important. INAA has a main advantage of non-destruction of air particulate samples, while inductively Coupled plasma with mass spectrometry (ICP-MS) encounters the most significant difficulties in pre-treatment (digestion, fusion, and dilution) and polyatomic spectral interferences for interest toxic elements, Although INAA is still reference method, a number of factors (disadvantages of cost, complexity of the instruments, and scarcity of nuclear reactor) limit its applications. To date, the use of collision cell technology ICP-MS (CCT-ICP-MS) is recommended instead of typical ICP-MS for the analysis of the toxic elements; this is because CCT-ICP-MS technique prevents polyatomic spectral interferences despite of contamination and volatile effects. In this study, a number of toxic elements in reference material, NIST SRM 2783 (air particulate on filter media) were determined by INAA, CCT-ICP-MS, and ICP-MS. For both ICP methods, the filters were decomposed by microwave digestion with 5mL nitric acid. The analytical results by three methods were compared with certificated data; the INAA results showed the most accurate and precise data sets for all target elements among three methods. In detail, the deviation between analytical results and SRM's by INAA fell below 10% for all elements excluding As (14%), while those by CCT-ICP-MS were about 20%. For ICP-MS, the result does not agree with certificated data for several elements, because polyatomic spectral interference (due to 40Ar35Cl, 40Ar23Na, and 35Cl16O) generate positive error of analytical result for As, Cu, and V. Based on our result, INAA is still one of the most powerful

  10. Law and Islamic finance: How legal origins affect Islamic finance development?

    Directory of Open Access Journals (Sweden)

    Rihab Grassa

    2014-09-01

    Full Text Available Many researchers have shown that differences in legal origin explain differences in financial development. Using historical comparisons and cross-country regressions for 30 countries observed for the period from 2005 to 2010, this study tried to assess if different legal origins impacted on the development of Islamic finance. More particularly, this paper tried to assess empirically why and how Shari'a Law's legal origins adopted wholly or partially (combined with Common or Civil Law could explain the level of development of Islamic finance in different jurisdictions. Firstly, we found that countries adopting a Shari'a legal system had a very well developed Islamic financial system. Secondly, we found that countries, adopting a mixed legal system based on Common Law and Shari'a Law, were characterized by the flexibility of their legal systems to make changes to their laws in response to the changing socioeconomic conditions and that these helped the development of the Islamic financial industry. However, we found that countries, adopting a mixed legal system based on both Civil Law and Shari'a Law, were less flexible in making changes to their old laws and this thwarted the development of the Islamic financial industry in these countries. Thirdly, we found that the concentration of Muslim population (the percentage of Muslim population had a positive effect on the development of the Islamic banking system. Also, the level of income had a positive and significant effect on the development of Islamic banking.

  11. Rate of Physical Growth and Its Affect on Head Start Children's Motor and Cognitive Development.

    Science.gov (United States)

    Marcon, Rebecca A.

    In the United States, growth retardation is higher among low-income children, with adverse cognitive effects of undernutrition more prevalent when combined with poverty. This study examined anthropometric indicators of physical development and their relationship to motor and cognitive development in Head Start children. Motor integration and…

  12. Social Brain Development and the Affective Consequences of Ostracism in Adolescence

    Science.gov (United States)

    Sebastian, Catherine; Viding, Essi; Williams, Kipling D.; Blakemore, Sarah-Jayne

    2010-01-01

    Recent structural and functional imaging studies have provided evidence for continued development of brain regions involved in social cognition during adolescence. In this paper, we review this rapidly expanding area of neuroscience and describe models of neurocognitive development that have emerged recently. One implication of these models is…

  13. FACTORS AFFECTING EFFICIENT CONSTRUCTION PROJECT DESIGN DEVELOPMENT: A PERSPECTIVE FROM INDIA

    Directory of Open Access Journals (Sweden)

    Devanshu Pandit

    2015-12-01

    Full Text Available Internationally projects exhibit time and cost overrun. It is observed that problems during design development contribute significantly to delays. In India, projects undertaken by government were largely planned and designed by departmental planners and engineers. However, after globalization, projects have increased in number resulting in design outsourcing, but with attendant challenges. The paper is aimed at identifying and analysing factors in the design development phase that can have impact on project success. 30 factors related to design development were identified through two separate brainstorming sessions. A questionnaire was then administered to determine importance ranking of these factors. Relative importance index (RII was used to prioritise these factors. Top ten factors in design development identified using RII include structural design parameters, soil investigations, design quality control, topographic survey, and architectural design parameters. The results can help firms improve their design development practices by prioritising activities that could have more impact on project performance.

  14. FEATURES OF SMALL BUSINESS DEVELOPMENT IN THE CIS COUNTRIES: DOES INSTITUTIONAL ENVIRONMENT AFFECT

    Directory of Open Access Journals (Sweden)

    Nataliia Viktorovna Ostapenko

    2014-07-01

    Full Text Available The article analyzes the development of small businesses at the national level through a comparative analysis between the former Soviet countries – Ukraine, Russia, Belarus, Kazakhstan, Uzbekistan, and Kyrgyzstan. These countries are comparable by the previous path dependence (the period of the USSR, communism, by the position of the geographical location, as well as by similarity of cultural development. As can be seen from the analysis, which was conducted in article, the quantitative characteristics of small business development in the above countries are similar, based on the dependence on foreign markets and conditions in national economies. However, qualitative indicators of small business development in these countries are different. These differences can be attributed to the activities of the institutional environment (formal and informal institutions and its impact on the national economy. Conclusions about the effectiveness of quality of development of small business sector through the analysis of its contribution to the national economy are done.

  15. How does real affect affect affect recognition in speech?

    NARCIS (Netherlands)

    Truong, Khiet Phuong

    2009-01-01

    The aim of the research described in this thesis was to develop speech-based affect recognition systems that can deal with spontaneous (‘real’) affect instead of acted affect. Several affect recognition experiments with spontaneous affective speech data were carried out to investigate what combinati

  16. Selective Serotonin Reuptake Inhibitors Affect Neurobehavioral Development in the Human Fetus

    NARCIS (Netherlands)

    Mulder, Eduard J. H.; Ververs, Frederique F. T.; de Heus, Roel; Visser, Gerard H. A.

    2011-01-01

    The aim of this prospective study was to investigate whether selective serotonin reuptake inhibitors (SSRIs) utilized by pregnant women influence fetal neurobehavioral development. In this observational study we investigated developmental milestones of fetal behavior during the pregnancy of women wi

  17. Socioeconomic Factors Affecting Farmers’ Awareness of Clean Development Mechanism Projects: Case of Smallholder Forest Carbon Projects

    OpenAIRE

    Oscar I. Ayuya; Job K. Lagat; John M. Mironga

    2011-01-01

    The objective of the study was to identify the socio-economic and institutional factors which influence the level of awareness of Clean Development Mechanism (CDM) projects and in so doing to highlight the policy implications for the stakeholders when designing clean development mechanism projects among smallholder farmers. Findings shows that 23% of the farmers were correctly aware of the project and the results of the ordered logit model indicate that age, gender, education level, group mem...

  18. How can trade unionism affect welfare consequences of trade and investment reforms in a developing economy?

    OpenAIRE

    Chaudhuri, Sarbajit

    2014-01-01

    This paper explains the existence of intersectoral wage differential in a developing economy in terms of trade union behavior in the formal sector industry and analyzes its role in predicting the outcomes of trade and investment reforms on welfare. It provides theoretical explanations of certain real life phenomena e.g. why the developing countries are yearning for foreign capital despite the standard immiserizing result and why these countries are not reducing the tariff rates beyond certain...

  19. How Does Foreign Bank Entry Affect Financial Inclusion in Emerging and Developing Economies?

    OpenAIRE

    Sasidaran Gopalan; Ramikishen S. Rajan

    2015-01-01

    An important dimension of the effects of foreign bank entry on financial sector development relates to that of financial inclusion. Despite its policy significance, the empirical literature offers little evidence on the impact of bank competition generally or foreign bank entry specifically on financial inclusion. This paper examines the relationship between foreign bank entry and financial inclusion for a panel of 57 emerging and developing economies over the period 2004-2009. The empirical ...

  20. Oakleaf: an S locus-linked mutation of Primula vulgaris that affects leaf and flower development

    OpenAIRE

    Cocker, Jonathan; Webster, Margaret; Li, Jinhong; Wright, Jonathan; Kaithakottil, Gemy; Swarbreck, David; Gilmartin, Philip

    2015-01-01

    •In Primula vulgaris outcrossing is promoted through reciprocal herkogamy with insect-mediated cross-pollination between pin and thrum form flowers. Development of heteromorphic flowers is coordinated by genes at the S locus. To underpin construction of a genetic map facilitating isolation of these S locus genes, we have characterised Oakleaf, a novel S locus-linked mutant phenotype. •We combine phenotypic observation of flower and leaf development, with classical genetic analysis and next-ge...

  1. Inhibition of polyamine oxidase activity affects tumor development during the maize-Ustilago maydis interaction.

    Science.gov (United States)

    Jasso-Robles, Francisco Ignacio; Jiménez-Bremont, Juan Francisco; Becerra-Flora, Alicia; Juárez-Montiel, Margarita; Gonzalez, María Elisa; Pieckenstain, Fernando Luis; García de la Cruz, Ramón Fernando; Rodríguez-Kessler, Margarita

    2016-05-01

    Ustilago maydis is a biotrophic plant pathogenic fungus that leads to tumor development in the aerial tissues of its host, Zea mays. These tumors are the result of cell hypertrophy and hyperplasia, and are accompanied by the reprograming of primary and secondary metabolism of infected plants. Up to now, little is known regarding key plant actors and their role in tumor development during the interaction with U. maydis. Polyamines are small aliphatic amines that regulate plant growth, development and stress responses. In a previous study, we found substantial increases of polyamine levels in tumors. In the present work, we describe the maize polyamine oxidase (PAO) gene family, its contribution to hydrogen peroxide (H2O2) production and its possible role in tumor development induced by U. maydis. Histochemical analysis revealed that chlorotic lesions and maize tumors induced by U. maydis accumulate H2O2 to significant levels. Maize plants inoculated with U. maydis and treated with the PAO inhibitor 1,8-diaminooctane exhibit a notable reduction of H2O2 accumulation in infected tissues and a significant drop in PAO activity. This treatment also reduced disease symptoms in infected plants. Finally, among six maize PAO genes only the ZmPAO1, which encodes an extracellular enzyme, is up-regulated in tumors. Our data suggest that H2O2 produced through PA catabolism by ZmPAO1 plays an important role in tumor development during the maize-U. maydis interaction. PMID:26926794

  2. RECENT DECISIONS AFFECTING THE DEVELOPMENT OF THE MARCELLUS SHALE IN PENNSYLVANIA

    Directory of Open Access Journals (Sweden)

    Kevin C Abbott

    2011-05-01

    Full Text Available Pennsylvania has a long history of natural gas exploration and development beginning in the 1800's. Despite having some of the country's oldest jurisprudence dealing with oil and gas disputes, Pennsylvania case law regarding oil and gas operations is relatively undeveloped in comparison to states like Texas and Oklahoma. With the boom in leasing and developing in the region in the last few years, there has also been an increase in oil and gas litigation in Pennsylvania state and federal courts. This paper will discuss the recent decisions that have impacted the development of Marcellus law in Pennsylvania, as well as identify some of the significant pending issues that are worth watching.

  3. How does imperviousness develop and affect runoff generation in an urbanizing watershed?

    Directory of Open Access Journals (Sweden)

    Gerald Krebs

    2013-08-01

    Full Text Available Imperviousness associated with urbanization remains one of the biggest challenges in sustainable urban design. The replacement of forests, marshlands, buffers, and wetlands with impervious surfaces, strongly influences hydrological processes in urbanizing areas. This study analyzed the contribution of four constructed surfaces types – roofs, yards, roads, and an international airport – to surface runoff within a 21 km2 watershed, and presents the development over five decades (1977−2030. The land-cover model, used to assess watershed imperviousness in 2030, utilized coefficients between impervious areas generating surface runoff and the floor area, developed during the study. The conducted imperviousness analysis allowed the evaluation of land-use development impacts on the stream network, and the identification of hydrologically active areas for urban planning and stormwater management. Research revealed the importance of yard imperviousness related to suburban residential housing for stormwater runoff generation, and the impacts of transport-related imperviousness on stormwater runoff.

  4. Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development

    International Nuclear Information System (INIS)

    Oligodendrocytes (OLs) are the glial cells of the central nervous system (CNS) classically known to be devoted to the formation of myelin sheaths around most axons of the vertebrate brain. We have addressed the role of these cells during cerebellar development, by ablating OLs in vivo. Previous analyses had indicated that OL ablation during the first six postnatal days results into a striking cerebellar phenotype, whose major features are a strong reduction of granule neurons and aberrant Purkinje cells development. These two cell types are highly interconnected during cerebellar development through the production of molecules that help their proliferation, differentiation and maintenance. In this article, we present data showing that OL ablation has major effects on the physiology of Purkinje (PC) and granule cells (GC). In particular, OL ablation results into a reduction of sonic hedgehog (Shh), Brain Derived Neurotrophic Factor (BDNF), and Reelin (Rln) expression. These results indicate that absence of OLs profoundly alters the normal cerebellar developmental program

  5. Systematization of the Chernobyl affected enterprises and the choice of the forms of their economic development

    International Nuclear Information System (INIS)

    The procedure of systematisation of agricultural enterprises with usage of multifactor expert-statistical analysis is offered. Multifactorial classification of 181 facilities of eleven polluted areas of the Gomel region and one area of the Brest region, injured with Chernobyl accident is carried out. The mechanism of the multifactorial statistical analysis of economic activities of the agricultural enterprises which will allow to allocate six groups of classes of facilities is offered, each of which needs development of separate strategy of development in view of specificity of classes of facilities. Directly the business - plan for development of a concrete facilities should be made on the basis of the appropriate strategic circuit and features of ability to live of this facilities. In the long term ordering of facilities by the technique offered above may be used for introduction the approach in state planning and regulation of activity of agrarian and industrial complex

  6. Development and Evaluation of the Method with an Affective Interface for Promoting Employees' Morale

    Science.gov (United States)

    Fujino, Hidenori; Ishii, Hirotake; Shimoda, Hiroshi; Yoshikawa, Hidekazu

    For the sustainable society, organization management not based on the mass production and mass consumption but having the flexibility to meet to various social needs precisely is required. For realizing such management, the emploees' work morale is required. Recently, however, the emploees' work morale is tend to decrease. Therefore, in this study, the authors developed the model of the method for promoting and keeping employees' work morale effectively and efficiently. Especially the authors thought “work morale” of “attitude to the work”. Based on this idea, it could be considered that the theory of the persuasion psychology and various persuasion techniques. Therefore, the model of the method applying the character agent was developed based on the forced compliance which is one of persuasion techniques based on the theory of the cognitive dissonance. By the evaluation experiment using human subjects, it was confirmed that developed method could improve workers' work morle effectively.

  7. Development of standards for chemical and biological decontamination of buildings and structures affected by terrorism

    Energy Technology Data Exchange (ETDEWEB)

    Lumley, T.C.; Volchek, K.; Fingas, M. [Environment Canada, Ottawa, ON (Canada). Emergencies Science and Technology Division, Environmental Technology Centre, Science and Technology Branch; Hay, A.W.M. [Leeds Univ., Leeds (United Kingdom)

    2006-07-01

    Currently, there are no suitable standards for determining levels of safety when reoccupying a building that has been recommissioned following a biological or chemical attack. For that reason, this study focused on developing clean-up standards for decontaminating buildings and construction materials after acts of terrorism. Several parameters must be assessed when determining the course of action to decontaminate toxic agents and to rehabilitate facilities. First, the hazardous substance must be positively identified along with the degree of contamination and information on likely receptors. Potential exposure route is also a key consideration in the risk assessment process. A key objective of the study was to develop specific guidelines for ascertaining and defining clean. In particular, standards for chemical and biological agents that pose a real or potential risk for use as agents of terrorism will be developed. The selected agents for standards development were ammonia, fentanyl, malathion, mustard gas, potassium cyanide, ricin, sarin, hepatitis A virus, and bacillus anthracis. The standards will be developed by establishing the relationship between the amount of exposure and expected health effects; assessing real and potential risks by identifying individuals at risk and consideration of all exposure routes; and, characterizing the risk to determine the potential for toxicity or infectivity. For non-carcinogens, this was done through the analysis of other known guidelines. Cancer-slope factors will be considered for carcinogens. The standards will be assessed in the laboratory using animal models. The guidelines and standards are intended for first-responders and are scheduled for development by the end of 2006. 15 refs., 3 tabs.

  8. Pseudobulbar affect in multiple sclerosis: toward the development of innovative therapeutic strategies.

    Science.gov (United States)

    Miller, Ariel

    2006-06-15

    Pseudobulbar affect (PBA), a condition involving involuntary and uncontrollable episodes of crying and/or laughing, occurs frequently in patients with a variety of neurological disorders, including amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury, dementia including Alzheimer's disease, and multiple sclerosis (MS). Although PBA results in considerable distress for patients and caretakers, it is underrecognized and undertreated. Agents used to treat psychiatric disorders--particularly tricyclic antidepressants and selective serotonin reuptake inhibitors--are useful in alleviating PBA, but act on diffuse neural networks rather than targeting those involved in emotional motor expression. As a result of their nonspecific activity, these agents are associated with a range of unwanted effects that preclude many patients from using them. Dextromethorphan, a common cough suppressant, specifically targets sigma(1) receptors concentrated in the brainstem and cerebellum, thus providing the possibility of targeting regions implicated in emotional expression. When administered in a fixed combination with quinidine, dextromethorphan is effective in treating PBA in patients with ALS, and preliminary results suggest that this therapy also is effective in treating MS-related PBA. PMID:16674978

  9. Genetic mapping of quantitative trait loci affecting susceptibility in chicken to develop pulmonary hypertension syndrome.

    Science.gov (United States)

    Rabie, T S K M; Crooijmans, R P M A; Bovenhuis, H; Vereijken, A L J; Veenendaal, T; van der Poel, J J; Van Arendonk, J A M; Pakdel, A; Groenen, M A M

    2005-12-01

    Pulmonary hypertension syndrome (PHS), also referred to as ascites syndrome, is a growth-related disorder of chickens frequently observed in fast-growing broilers with insufficient pulmonary vascular capacity at low temperature and/or at high altitude. A cross between two genetically different broiler dam lines that originated from the White Plymouth Rock breed was used to produce a three-generation population. This population was used for the detection and localization of quantitative trait loci (QTL) affecting PHS-related traits. Ten full-sib families consisting of 456 G2 birds were typed with 420 microsatellite markers covering 24 autosomal chromosomes. Phenotypic observations were collected on 4202 G3 birds and a full-sib across family regression interval mapping approach was used to identify QTL. There was statistical evidence for QTL on chicken chromosome 2 (GGA2), GGA4 and GGA6. Suggestive QTL were found on chromosomes 5, 8, 10, 27 and 28. The most significant QTL were located on GGA2 for right and total ventricular weight as percentage of body weight (%RV and %TV respectively). A related trait, the ratio of right ventricular weight as percentage to total ventricular weight (RATIO), reached the suggestive threshold on this chromosome. All three QTL effects identified on GGA2 had their maximum test statistic in the region flanked by markers MCW0185 and MCW0245 (335-421 cM). PMID:16293119

  10. Eukaryotic release factor 1-2 affects Arabidopsis responses to glucose and phytohormones during germination and early seedling development

    OpenAIRE

    Zhou, Xiangjun; Cooke, Peter; Li, Li

    2009-01-01

    Germination and early seedling development are coordinately regulated by glucose and phytohormones such as ABA, GA, and ethylene. However, the molecules that affect plant responses to glucose and phytohormones remain to be fully elucidated. Eukaryotic release factor 1 (eRF1) is responsible for the recognition of the stop codons in mRNAs during protein synthesis. Accumulating evidence indicates that eRF1 functions in other processes in addition to translation termination. The physiological rol...

  11. Interaction Between Syndromic and Non-Syndromic Factors Affecting Speech and Language Development in Treacher-Collins Syndrome

    OpenAIRE

    Marziyeh Poorjavad

    2011-01-01

    Background: Treacher-Collins syndrome is a congenital craniofacial disorder with multiple anomalies. This syndrome affects the maxilla, mandible, eyes, middle and outer ears, and soft palate. Conductive hearing loss due to the deformities of the middle and external ears is prevalent. The characteristics of this syndrome include multiple and serious threats to normal communication development in children. In this study, speech and language features of a Persian speaking child with this syndrom...

  12. Does Chess Training Affect Conceptual Development of Six-Year-Old Children in Turkey?

    Science.gov (United States)

    Sigirtmac, Ayperi Dikici

    2012-01-01

    Many studies propose that chess is a game requiring cognitive skills and has positive effects on mental development. In recent years, chess training has also been emphasised as important during the early childhood period. However, no studies have been done with six-year-old children. The purpose of this study was to investigate whether or not…

  13. AtMYB103 is a crucial regulator of several pathways affecting Arabidopsis anther development

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Previous reports indicated that AtMYB103 has an important role in tapetum development,callose dissolution,and exine formation in A.thaliana anthers.Here,we further characterized its function in anther development by expression pattern analysis,transmission electron microscopy observation of the knockout mutant,and microarray analysis of downstream genes.A total of 818 genes differentially expressed between ms188 and the wild-type were identified by global expression profiling analysis.Functional classification showed that loss-of-function of AtMYB103 impairs cell wall modification,lipid metabolic pathways,and signal transduction throughout anther development.RNA in situ hybridization confirmed that transcription factors acting downstream of AtMYB103 (At1g06280 and At1g02040) were expressed in the tapetum and microspores at later stages,suggesting that they might have important roles in microsporogenesis.These results indicated that AtMYB103 is a crucial regulator of Arabidopsis anther development.

  14. Gender Differential Influences of Early Adolescent Risk Factors for the Development of Depressive Affect.

    Science.gov (United States)

    Stemmler, Mark; Petersen, Anne C.

    2005-01-01

    Based on a model by Cyranowski, J., et al. (2000), Arch. Gen. Psychiatry 57: 21-27, adolescents at-risk for the development of depressive symptoms were identified. Adolescents were considered at-risk if they had 2 or more of the following early adolescent risk factors: (1) insecure parental attachment, (2) anxious/inhibited temperament, (3) low…

  15. Vascular endothelial growth factor signaling affects both angiogenesis and osteogenesis during the development of scleral ossicles.

    Science.gov (United States)

    Jabalee, James; Franz-Odendaal, Tamara A

    2015-10-01

    Intramembranous ossification is a complex multi-step process which relies on extensive interactions among bone cells and surrounding tissues. The embryonic vasculature is essential in regulating endochondral ossification; however, its role during intramembranous ossification remains poorly understood, and in vivo studies are lacking. Previous research from our lab on the development of the intramembranous scleral ossicles has demonstrated an intriguing pattern of vascular development in which the areas of future osteogenesis remain avascular until after bone induction has occurred. Such avascular zones are located directly beneath each of the conjunctival papillae, epithelial structures which provide osteogenic signals to the underlying mesenchyme. Here we provide a high-resolution map of the developing vasculature from the time of ossicle induction to mineralization using a novel technique. We show that vegfa is expressed by the papillae and nearby mesenchymal tissue throughout HH 34-37, when vascular growth is taking place, and is down-regulated thereafter. Localized inhibition of Vegf results in expansion of the avascular zone surrounding the implanted papilla and mispatterning of the scleral ossicles. These results demonstrate that Vegf signaling could provide important insights into the complex relationship between bone and vasculature during intramembranous bone development. PMID:26210172

  16. Soy-Based Formula Does Not Adversely Affect Immune System Development in Neonatal Piglets

    Science.gov (United States)

    Breast-fed infants are less susceptible to infections and allergic reactions than those fed formula, suggesting that diet may influence neonatal immune system development. The goal of the present study was two fold: 1. to determine the effect of formula feeding relative to breast-feeding on neonata...

  17. MICROSTRUCTURE AND MECHANICAL PROPERTY DEVELOPMENT IN THE SIMULATED HEAT AFFECTED ZONE OF V TREATED HSLA STEELS

    Institute of Scientific and Technical Information of China (English)

    Y.T. Chen; A.M. Guo; L.X. Wu; J. Zeng; P.H. Li

    2006-01-01

    The simulated heat affected zone (HAZ) of the high strength low alloy (HSLA) steels containing 0%, 0.047%, 0.097% and 0.151% vanadium, respectively, were studied with Gleeble-2000 thermomechanical simulator to determine the influence of vanadium addition on the mechanical properties of the HAZ. The HAZ simulation involved reheating the samples to 1350℃, and then cooling to ambient temperature at a cooling rate of 5℃/s ranging from 800 to 500℃ (△t8/5=60s).The mechanical properties including tensile strength and -20℃ impact toughness were conducted. The microstructures of the base steel and the simulated HAZs were investigated using optical microscope, scanning electron microscope (SEM) and transmission electron microscope (TEM).Basedon the systematic examination, the present work confirmed that about 0.05% vanadium addition to low carbon low alloy steels resulted in expected balance of strength and toughness of the HAZ. And more than 0.10% levels addition led to detrimental toughness of the HAZ. SEM study showed that the simulated 0.097% and 0.151%V HAZs consisted of more coarse ferrite plates with greater and more M-A constituents along austenite grain and ferrite plate boundaries. The impact fracture surfaces of the simulated 0.097% and 0.151% V HAZs showed typically brittle mode with predominant cleavages. The size of the facet in the fracture surface increased with increasing vanadium level from 0.097% to 0.151%. As a result, the simulated 0.151% V HAZ has the lowest impact toughness of the four specimens.

  18. Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation

    DEFF Research Database (Denmark)

    Stapper, A.P.; Narasimhan, G.; Oman, D.E.;

    2004-01-01

    Extracellular polymers can facilitate the non-specific attachment of bacteria to surfaces and hold together developing biofilms. This study was undertaken to qualitatively and quantitatively compare the architecture of biofilms produced by Pseudomonas aeruginosa strain PAO1 and its alginate...... biofilm formation using confocal laser scanning microscopy. Biofilm Image Processing (BIP) and Community Statistics (COMSTAT) software programs were used to provide quantitative measurements of the two-dimensional biofilm images. All three strains formed distinguishable biofilm architectures, indicating...... that the production of alginate is not critical for biofilm formation. Observation over a period of 5 days indicated a three-stage development pattern consisting of initiation, establishment and maturation. Furthermore, this study showed that phenotypically distinguishable biofilms can be...

  19. Factors affecting the risk of developing lower back musculoskeletal disorders (MSDs) in experienced and inexperienced rodworkers.

    Science.gov (United States)

    Salas, Elizabeth A; Vi, Peter; Reider, Vanesa L; Moore, Anne E

    2016-01-01

    Injury and dropout rates during rodwork training appear to reflect difficulties encountered by apprentices adapting to increased physical demands of tying on slab, one of the rodworking tasks with the highest injury risk. Because experience influences work strategies, and consequently the risk of developing musculoskeletal disorders (MSDs), this study aimed to identify differences in work practices associated with tying rebar on slab, potentially relevant to back MSD development, in experienced and inexperienced rodworkers. Fourteen male rodworkers were recruited from either experienced (>2 years experience post apprenticeship), or inexperienced (<6 months experience) groups. Both tied an area with rebar laid on the ground. Trunk flexion/extension angles were measured. L4/L5 moments were estimated from T9 Erector Spinae EMG. Experienced workers were found to spend longer periods of time in trunk flexed postures, with lower peak L4/L5 moments. Our findings revealed practices associated with each group might have different implications on back health. PMID:26360195

  20. Dose of recombinant FSH and oestradiol concentration on day of HCG affect embryo development kinetics

    DEFF Research Database (Denmark)

    Muñoz, Manuel; Cruz, María; Humaidan, Peter;

    2012-01-01

    increase in the proportions of optimal timings of development, the differences observed were not significant, as shown by the percentages of embryos inside/outside these kinetic variables. In contrast, for gonadotrophin dosage and oestradiol concentration, this study observed differences in embryo...... development kinetics for some of the variables evaluated, which allowed the description of an optimal range of gonadotrophin dosage and oestradiol concentration. However, these kinetic differences did not translate into important distinctions in the proportion of optimal embryos with a higher implantation......During follicular growth, the follicle is exposed to an almost ever-changing composition of isoforms of FSH and LH, which causes a number of different and divergent biological effects. Through a time-lapse system, embryo kinetics were examined following the use of FSH only (recombinant FSH, r...

  1. Consumption rate of some proteinic diets affecting hypopharyngeal glands development in honeybee workers

    OpenAIRE

    Al-Ghamdi, Ahmad AlKazim; Al-Khaibari, Abeer M.; Omar, Mohamed O.

    2010-01-01

    The experiment was carried out under laboratory condition to study the consumption of some proteinic diets and their effect on hypopharyngeal glands (HPG) development during nursing period. The results showed that the bee bread and the pollen loads mixture with sugar (1:1) were more consumed by honeybee workers followed by Nectapol® and Yeast-Gluten mixture. The lowest consumption amount was recorded with traditional substitute.

  2. Using intervention mapping to develop a work-related guidance tool for those affected by cancer

    Directory of Open Access Journals (Sweden)

    Munir Fehmidah

    2013-01-01

    Full Text Available Abstract Background Working-aged individuals diagnosed and treated for cancer require support and assistance to make decisions regarding work. However, healthcare professionals do not consider the work-related needs of patients and employers do not understand the full impact cancer can have upon the employee and their work. We therefore developed a work-related guidance tool for those diagnosed with cancer that enables them to take the lead in stimulating discussion with a range of different healthcare professionals, employers, employment agencies and support services. The tool facilitates discussions through a set of questions individuals can utilise to find solutions and minimise the impact cancer diagnosis, prognosis and treatment may have on their employment, sick leave and return to work outcomes. The objective of the present article is to describe the systematic development and content of the tool using Intervention Mapping Protocol (IMP. Methods The study used the first five steps of the intervention mapping process to guide the development of the tool. A needs assessment identified the ‘gaps’ in information/advice received from healthcare professionals and other stakeholders. The intended outcomes and performance objectives for the tool were then identified followed by theory-based methods and an implementation plan. A draft of the tool was developed and subjected to a two-stage Delphi process with various stakeholders. The final tool was piloted with 38 individuals at various stages of the cancer journey. Results The tool was designed to be a self-led tool that can be used by any person with a cancer diagnosis and working for most types of employers. The pilot study indicated that the tool was relevant and much needed. Conclusions Intervention Mapping is a valuable protocol for designing complex guidance tools. The process and design of this particular tool can lend itself to other situations both occupational and more health

  3. Using intervention mapping to develop a work-related guidance tool for those affected by cancer

    OpenAIRE

    Munir Fehmidah; Kalawsky Katryna; Wallis Deborah J; Donaldson-Feilder Emma

    2013-01-01

    Abstract Background Working-aged individuals diagnosed and treated for cancer require support and assistance to make decisions regarding work. However, healthcare professionals do not consider the work-related needs of patients and employers do not understand the full impact cancer can have upon the employee and their work. We therefore developed a work-related guidance tool for those diagnosed with cancer that enables them to take the lead in stimulating discussion with a range of different ...

  4. Chicory (Cichorium intybus L.) and cereals differently affect gut development in broiler chickens and young pigs

    OpenAIRE

    Liu, Haoyu; Ivarsson, Emma; Lundh, Torbjörn; Lindberg, Jan Erik

    2013-01-01

    Dietary fiber, resistant to host-mediated digestion in the small intestine due to lack of endogenous enzymes, impacts many facets of animal health and is associated with gut development especially in young monogastrics. Furthermore, it can be used as in-feed antibiotic alternative. Chicory (Cichorium intybus L.) forage with high content of pectin (uronic acids as building blocks) is a novel class of dietary fiber that is chemically different from cereal grains (with high content of arabinoxyl...

  5. Plant quantity affects development and survival of a gregarious insect herbivore and its endoparasitoid wasp.

    OpenAIRE

    Minghui Fei; Rieta Gols; Feng Zhu; Harvey, Jeffrey A.

    2016-01-01

    Virtually all studies of plant-herbivore-natural enemy interactions focus on plant quality as the major constraint on development and survival. However, for many gregarious feeding insect herbivores that feed on small or ephemeral plants, the quantity of resources is much more limiting, yet this area has received virtually no attention. Here, in both lab and semifield experiments using tents containing variably sized clusters of food plants, we studied the effects of periodic food deprivation...

  6. Institutional factors that affect the development of the tourist industry in mazatlan

    Directory of Open Access Journals (Sweden)

    Jorge Rubén Ibarra Martínez

    2012-05-01

    Full Text Available The present work is a reflection of how the negative social practices that are presents in the coexistence forms of the economic agents, who integrate the tourist industry of Mazatlan, are the determining factor to explain the stagnation that is undergoing the city in the last years. The analysis of this essay was realized under the economic geography approach, which takes into account the specifications of a place to explain its conditions and potentialities for Development.

  7. Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system.

    OpenAIRE

    N.Berardi; Cellerino, A.; L. DOMENICI; Fagiolini, M.; Pizzorusso, T.; Cattaneo, A.; L Maffei

    1994-01-01

    Exogenous supply of nerve growth factor (NGF) prevents the effects of monocular deprivation. This suggests that visual afferents may be competing for an endogenous neurotrophic factor, related to NGF, whose production by postsynaptic cells depends on the activity of afferent fibers. To test the hypothesis that endogenous NGF may play a role in the functional and anatomical development of the rat geniculo cortical system, the physiological action of NGF in the rat visual system was antagonized...

  8. China’s language input system in the digital age affects children’s reading development

    OpenAIRE

    Tan, Li Hai; Xu, Min; Chang, Chun Qi; Siok, Wai Ting

    2012-01-01

    Written Chinese as a logographic system was developed over 3,000 y ago. Historically, Chinese children have learned to read by learning to associate the visuo-graphic properties of Chinese characters with lexical meaning, typically through handwriting. In recent years, however, many Chinese children have learned to use electronic communication devices based on the pinyin input method, which associates phonemes and English letters with characters. When children use pinyin to key in letters, th...

  9. Wnt affects symmetry and morphogenesis during post-embryonic development in colonial chordates

    OpenAIRE

    Di Maio, Alessandro; Setar, Leah; Tiozzo, Stefano; De Tomaso, Anthony W

    2015-01-01

    Background Wnt signaling is one of the earliest and most highly conserved regulatory pathways for the establishment of the body axes during regeneration and early development. In regeneration, body axes determination occurs independently of tissue rearrangement and early developmental cues. Modulation of the Wnt signaling in either process has shown to result in unusual body axis phenotypes. Botryllus schlosseri is a colonial ascidian that can regenerate its entire body through asexual buddin...

  10. A STUDY OF FACTOR AFFECTING THE SOFTWARE APPLICATION DEVELOPMENT IN INDONESIAN CREATIVE INDUSTRY

    Directory of Open Access Journals (Sweden)

    Adhi Nugroho Chandra

    2015-06-01

    Full Text Available The creative industries promising opportunities, especially the interactive game business. creative industries is still undeveloped, but lately has been showing its contribution to the economic development of Indonesia. Implementation of the Information and Communication Technology (ICT strategy is a new discourse that can provide great opportunities for the entrepreneurial. This study aims to reveal the level of implementation of ICT strategies, the role of government influence on the development of business, industry conditions as well as the existing value chain in the interactive games industry. Type of research conducted by descriptive research, qualitative analysis was based on the findings of desk research / literature, interview sources, and the researcher's own knowledge. Level of subjectivity can be minimized with the help of quantitative analysis and the selection of competent resource persons in the field interviews. Secondary data obtained from the creative economy planning books in 2025, which was published by the Ministry of Commerce of the Republic of Indonesia. Based on the research results, it is concluded that the implementation of ICT strategies by entrepreneurs in the interactive games industry is still less, and this is partly because in general the industry is still small-scale and micro enterprises, mash the industry is relatively new in the world of business, and entrepreneurs are still concentrating the creation, production, and distributio, commercialization are being developed. In general, interactive games industry is growing. In the future, need to research business model and business strategy, so it would complement the models developing strategy in the game interactive industry.

  11. A STUDY OF FACTOR AFFECTING THE SOFTWARE APPLICATION DEVELOPMENT IN INDONESIAN CREATIVE INDUSTRY

    OpenAIRE

    Adhi Nugroho Chandra; Yohannes Kurniawan

    2015-01-01

    The creative industries promising opportunities, especially the interactive game business. creative industries is still undeveloped, but lately has been showing its contribution to the economic development of Indonesia. Implementation of the Information and Communication Technology (ICT) strategy is a new discourse that can provide great opportunities for the entrepreneurial. This study aims to reveal the level of implementation of ICT strategies, the role of government influence on the devel...

  12. Factors Affecting the Development of Somatic Cell Nuclear Transfer Embryos in Cattle

    OpenAIRE

    Akagi, Satoshi; Matsukawa, Kazutsugu; TAKAHASHI, Seiya

    2014-01-01

    Nuclear transfer is a complex multistep procedure that includes oocyte maturation, cell cycle synchronization of donor cells, enucleation, cell fusion, oocyte activation and embryo culture. Therefore, many factors are believed to contribute to the success of embryo development following nuclear transfer. Numerous attempts to improve cloning efficiency have been conducted since the birth of the first sheep by somatic cell nuclear transfer. However, the efficiency of somatic cell cloning has re...

  13. How musical training affects cognitive development: rhythm, reward and other modulating variables

    OpenAIRE

    Ewa Aurelia Miendlarzewska; Wiebke Johanna Trost

    2014-01-01

    Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musi...

  14. SPL8, an SBP-box gene that affects pollen sac development in Arabidopsis

    OpenAIRE

    Unte, Ulrike S.; Sorensen, Anna-Marie; Pesaresi, Paolo; Gandikota, Madhuri; Leister, Dario; Saedler, Heinz; Huijser, Peter

    2003-01-01

    SQUAMOSA PROMOTER BINDING PROTEIN-box genes (SBP-box genes) encode plant-specific proteins that share a highly conserved DNA binding domain, the SBP domain. Although likely to represent transcription factors, little is known about their role in development. In Arabidopsis, SBP-box genes constitute a structurally heterogeneous family of 16 members known as SPL genes. For one of these genes, SPL8, we isolated three independent transposon-tagged mutants, all of which exhibited a strong reduction...

  15. Polyphenol oxidase affects normal nodule development in red clover (Trifolium pratense L.)

    OpenAIRE

    Webb, K Judith; Cookson, Alan; Allison, Gordon; Sullivan, Michael L.; Winters, Ana L.

    2014-01-01

    Polyphenol oxidase (PPO) may have multiple functions in tissues depending on its cellular or tissue localization. Here we use PPO RNAi transformants of red clover (Trifolium pratense) to determine the role PPO plays in normal development of plants, and especially in N2-fixing nodules. In red clover, PPO was not essential for either growth or nodule production, or for nodule function in plants grown under optimal, N-free conditions. However, absence of PPO resulted in a more reduced environmen...

  16. Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function.

    Science.gov (United States)

    Houbrechts, Anne M; Vergauwen, Lucia; Bagci, Enise; Van Houcke, Jolien; Heijlen, Marjolein; Kulemeka, Bernard; Hyde, David R; Knapen, Dries; Darras, Veerle M

    2016-03-15

    Retinal development in vertebrates relies extensively on thyroid hormones. Their local availability is tightly controlled by several regulators, including deiodinases (Ds). Here we used morpholino technology to explore the roles of Ds during eye development in zebrafish. Transcriptome analysis at 3 days post fertilization (dpf) revealed a pronounced effect of knockdown of both T4-activating Ds (D1D2MO) or knockdown of T3-inactivating D3 (D3bMO) on phototransduction and retinoid recycling. This was accompanied by morphological defects (studied from 1 to 7 dpf) including reduced eye size, disturbed retinal lamination and strong reduction in rods and all four cone types. Defects were more prominent and persistent in D3-deficient fish. Finally, D3-deficient zebrafish larvae had disrupted visual function at 4 dpf and were less sensitive to a light stimulus at 5 dpf. These data demonstrate the importance of TH-activating and -inactivating Ds for correct zebrafish eye development, and point to D3b as a central player. PMID:26802877

  17. Does low gas permeability of rigid-shelled gekkotan eggs affect embryonic development?

    Science.gov (United States)

    Andrews, Robin M; Thompson, Michael B; Greene, Virginia W

    2013-06-01

    Parchment-shelled eggs are characteristic of most squamates, including the basal clades of gekkotan lizards. The majority of gekkotan lizards, however, produce rigid-shelled eggs that are highly impermeable to gas exchange; eggs are laid in dry sites and experience a net loss of water during incubation. We tested the hypothesis that the 1,000-fold lower rate of oxygen diffusion through the shells of rigid- compared to parchment-shelled eggs imposes a physiological cost on development. To do this, we contrasted species with rigid and with parchment shells with regards to (1) rates of embryonic metabolism and (2) rates and patterns of development of the yolk sac and chorioallantois, the vascularized extra-embryonic membranes that transport oxygen to embryonic tissues. Metabolic rates of embryos from the rigid-shelled eggs of Gehyra variegata did not differ from those of the parchment-shelled eggs of Oedura lesueurii. Moreover, maximum metabolic rates of gekkotans with rigid shells did not differ from those of gekkotan or scincid lizards with parchment shells. In contrast, the yolk sac covered more of the surface area of the egg at oviposition, and the chorioallantois reached its full extent earlier for the species with rigid shelled eggs (Chondrodactylus turneri, G. variegata) than for the species with parchment-shelled eggs (Eublepharis macularius, O. lesueurii). Differences in the temporal patterns of yolk sac and chorioallantois development would thus serve to compensate for low rates of oxygen diffusion through rigid shells of gekkotans. PMID:23495191

  18. Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Roepke, Troy A. [Bodega Marine Laboratory, University of California, Davis, POB 247, Bodega Bay, CA 94923 (United States); Snyder, Mark J. [Bodega Marine Laboratory, University of California, Davis, POB 247, Bodega Bay, CA 94923 (United States); Cherr, Gary N. [Bodega Marine Laboratory, University of California, Davis, POB 247, Bodega Bay, CA 94923 (United States) and Departments of Environmental Toxicology and Nutrition, One Shields Avenue, University of California, Davis, CA 95616 (United States)]. E-mail: gncherr@ucdavis.edu

    2005-01-26

    Environmental endocrine disrupting compounds (EDCs) are a wide variety of chemicals that typically exert effects, either directly or indirectly, through receptor-mediated processes, thus mimicking endogenous hormones and/or inhibiting normal hormone activities and metabolism. Little is known about the effects of EDCs on echinoderm physiology, reproduction and development. We exposed developing sea urchin embryos (Strongylocentrotus purpuratus and Lytechinus anamesus) to two known EDCs (4-octylphenol (OCT), bisphenol A (BisA)) and to natural and synthetic reproductive hormones (17{beta}-estradiol (E{sub 2}), estrone (E{sub 1}), estriol (E{sub 3}), progesterone (P{sub 4}) and 17{alpha}-ethynylestradiol (EE{sub 2})). In addition, we studied two non-estrogenic EDCs, tributyltin (TBT) and o,p-DDD. Successful development to the pluteus larval stage (96 h post-fertilization) was used to define EDC concentration-response relationships. The order of compound potency based on EC{sub 50} values for a reduction in normal development was as follows: TBT {sub L.anamesus} > OCT > TBT {sub S.{sub p}}{sub urpuratus} >> E{sub 2} > EE{sub 2} > DDD >> BisA > P{sub 4} > E{sub 1} >> E{sub 3}. The effect of TBT was pronounced even at concentrations substantially lower than those commonly reported in heavily contaminated areas, but the response was significantly different in the two model species. Sea urchin embryos were generally more sensitive to estrogenic EDCs and TBT than most other invertebrate larvae. Stage-specific exposure experiments were conducted to determine the most sensitive developmental periods using blastula, gastrula and post-gastrula (pluteus) stages. The stage most sensitive to E{sub 2}, OCT and TBT was the blastula stage with less overall sensitivity in the gastrula stage, regardless of concentration. Selective estrogen receptor modulators (SERMs) were added to the experiments individually and in combination with estrogenic EDCs to interfere with potential receptor

  19. Growth and development of Mentha piperita L. in nutrient solution as affected by rates of potassium

    Directory of Open Access Journals (Sweden)

    Janice Valmorbida

    2007-05-01

    Full Text Available The influence of potassium on the development of Mentha piperita L. was evaluated in the plants grown in nutritive solution modified by variations in potassium, at 6.0, 3.0, and 1.5 mmol L-1, establishing differences between treatments and corresponding, respectively, to the concentration proposed in Hoagland and Arnon's no. 2 solution and reductions by 50% and 75%. Until 21 days after transplanting, the concentration used was diluted to 50% in the three treatments. Evaluations consisted of leaf area, development of the above-ground part, and dry matter of different plant organs. Plants grown with 1.5/3.0 mmol L-1 K showed greater development of the above-ground part. Other variables were not different among plants in the different treatments.A influência do potássio no desenvolvimento de Mentha piperita L. foi avaliada em plantas cultivadas em solução nutritiva modificada pela variação de potássio, com 6.0, 3.0 e 1.5 mmol L-1, que estabeleceram as diferenças entre tratamentos e corresponderam, respectivamente, a sua concentração proposta na solução nº 2 de Hoagland e Arnon e diminuição em 50% e 75%. Até os 21 dias após o transplante a concentração utilizada foi diluída em 50% nos três tratamentos. Avaliou-se área foliar, desenvolvimento da parte aérea e matéria secas dos diferentes órgãos. Plantas cultivadas com 1.5/3.0 mmol L-1 K apresentaram maior desenvolvimento da parte aérea. Demais variáveis não diferiram entre as plantas dos diferentes tratamentos.

  20. Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development.

    Science.gov (United States)

    Jansen, Sarah; Esmaeilpour, Tahereh; Pantaleon, Marie; Kaye, Peter L

    2006-03-01

    Cleavage-stage embryos have an absolute requirement for pyruvate and lactate, but as the morula compacts, it switches to glucose as the preferred energy source to fuel glycolysis. Substrates such as glucose, amino acids, and lactate are moved into and out of cells by facilitated diffusion. In the case of lactate and pyruvate, this occurs via H+-monocarboxylate cotransporter (MCT) proteins. To clarify the role of MCT in development, transport characteristics for DL-lactate were examined, as were mRNA expression and protein localisation for MCT1 and MCT3, using confocal laser scanning immunofluorescence in freshly collected and cultured embryos. Blastocysts demonstrated significantly higher affinity for DL-lactate than zygotes (Km 20 +/- 10 vs 87 +/- 35 mmol lactate/l; P = 0.03 by linear regression) but was similar for all stages. For embryos derived in vivo and those cultured with glucose, MCT1 mRNA was present throughout preimplantation development, protein immunoreactivity appearing diffuse throughout the cytoplasm with brightest intensity in the outer cortical region of blastomeres. In expanding blastocysts, MCT1 became more prominent in the cytoplasmic cortex of blastomeres, with brightest intensity in the polar trophectoderm. Without glucose, MCT1 mRNA was not expressed, and immunoreactivity dramatically reduced in intensity as morulae died. MCT3 mRNA and immunoreactivity were not detected in early embryos. The differential expression of MCT1 in the presence or absence of glucose demonstrates that it is important in the critical regulation of pH and monocarboxylate transport during preimplantation development, and implies a role for glucose in the control of MCT1, but not MCT3, expression. PMID:16514190

  1. Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder

    DEFF Research Database (Denmark)

    Severinsen, Jacob; Bjarkam, Carsten; Kiær-Larsen, Stine;

    . Quantitative mRNA analysis in developing fetal pig brain revealed spatiotemporal differences with high expression at early embryonic stages, with intense nuclear and cytosolar immunohistochemical staining of the neuroepithelial layer and early neuroblasts, whilst more mature neurons at later embryonic stages...... controls (p-value 2.8x10-7).Expression analysis of BRD1 mRNA revealed widespread expression in mammalian brain tissue, which was substantiated by immunohistochemical detection of BRD1 protein in the nucleus, perikaryal cytosol and proximal dendrites of the neurons in the adult rat, rabbit and human CNS...

  2. Body condition of gilts at the end of gestation affects their mammary development.

    Science.gov (United States)

    Farmer, C; Duarte, C R A; Vignola, M; Palin, M-F

    2016-05-01

    The impact of body condition at 110 d of gestation on mammary gland development, mammary gene expression, and hormonal and metabolite status of gilts was studied. Thirty-nine gilts were equally divided into 3 groups based on their backfat thickness at the end of gestation: 1) low backfat (LBF; 12-15 mm), 2) medium backfat (MBF; 17-19 mm), or 3) high backfat (HBF; 21-26 mm). Gilts had similar BW (138.1 ± 8.2 kg) and backfat thicknesses (16.4 ± 1.0 mm) at mating and the 3 groups were achieved via ingestion of varying amounts of feed throughout gestation. Jugular blood samples were obtained from all gilts at mating and at 109 d of gestation to assess hormonal and metabolic statuses, and animals were slaughtered on d 110 to collect mammary glands for compositional analyses and for measure of gene expression. The LBF gilts had less extraparenchymal tissue ( 0.10). There was a tendency for circulating leptin concentrations on d 109 of gestation to be lower in LBF gilts than in MBF gilts ( 0.10). Current results demonstrate that being too thin at the end of gestation (12-15 mm backfat) has a negative impact on mammary development in gilts, whereas having backfats varying from 17 to 26 mm seems to have no detrimental effects on mammogenesis. Backfat thickness in late pregnancy must therefore be considered to achieve optimal sow lactation performance. PMID:27285687

  3. Socioeconomic Factors Affecting Farmers’ Awareness of Clean Development Mechanism Projects: Case of Smallholder Forest Carbon Projects

    Directory of Open Access Journals (Sweden)

    Oscar I. Ayuya

    2011-05-01

    Full Text Available The objective of the study was to identify the socio-economic and institutional factors which influence the level of awareness of Clean Development Mechanism (CDM projects and in so doing to highlight the policy implications for the stakeholders when designing clean development mechanism projects among smallholder farmers. Findings shows that 23% of the farmers were correctly aware of the project and the results of the ordered logit model indicate that age, gender, education level, group membership, existence of tree farming and contact with extension services was found to influence awareness level of smallholder forest Carbon projects. To assist the community to adapt to climate change and produce sufficiently on a sustainable basis and achieve the desired food security under climate change challenges, the study recommends policies to increase awareness of such agro-environmental initiatives and that of extension providers should distinguish their clientele anchored on vital demographic characteristics such as age and gender. If the probability of younger farmers to be aware this initiative is higher, extension communications should be directed to such age group, particularly during initial stages project information dissemination.

  4. Mixtures of environmentally relevant endocrine disrupting chemicals affect mammary gland development in female and male rats

    DEFF Research Database (Denmark)

    Mandrup, Karen Riiber; Johansson, Hanna Katarina Lilith; Boberg, Julie; Pedersen, Anne S.; Mortensen, Mette Sidsel; Jørgensen, Jennifer Solgaard; Vinggaard, Anne Marie; Hass, Ulla

    2015-01-01

    Estrogenic chemicals are able to alter mammary gland development in female rodents, but little is known on the effects of anti-androgens and mixtures of endocrine disrupting chemicals (EDCs) with dissimilar modes of action. Pregnant rat dams were exposed during gestation and lactation to mixtures...... of environmentally relevant EDCs with estrogenic, anti-androgenic or dissimilar modes of action (TotalMix) of 100-, 200- or 450-fold high end human intake estimates. Mammary glands of prepubertal and adult female and male offspring were examined. Oestrogens increased mammary outgrowth in prepubertal...... females and the mRNA level of matrix metalloproteinase-3, which may be a potential biomarker for increased outgrowth. Mixtures of EDCs gave rise to ductal hyperplasia in adult males. Adult female mammary glands of the TotalMix group showed morphological changes possibly reflecting increased prolactin...

  5. Development of microstructure affected by in-mould manipulation in polymer composites and nanocomposites

    Directory of Open Access Journals (Sweden)

    M. Bilewicz

    2008-11-01

    Full Text Available Purpose: Investigation of microstructure of polymer nanocomposites subjected to high shear rates during solidification phase.Design/methodology/approach: Injection moulding technique combined with specially designed mould gives possibility to manipulate solidifying polymer or polymer’s mixture inside cavity mould.Findings: Significant increment of fracture energy depending of applied conditions including melt temperature and time of shearing of polymer blend.Research limitations/implications: Obtained nanocomposites contain better mechanical properties comparing to polymer composites and application of SCORIM technique brought satisfying and improved results comparing to conventional methods.Practical implications: Implicated advanced technique to conventional injection moulding gives high performance material with good increased toughness and nanoplatteled particles, uniformly distributed, thanks to the applied technique, inside matrix well reinforce final products.Originality/value: SCORIM technique is rarely used technology and has influence on creation and development of morphology of processed materials.

  6. Factors affecting illness in the developing world: chronic disease, mental health and traditional medicine cures.

    Science.gov (United States)

    Douthit, Nathan T; Astatk, Hailemariam Alemu

    2016-01-01

    This is a case report of a 24-year-old Ethiopian woman with a medical history of hepatosplenic schistosomiasis. She suffers from chronic liver failure and portal hypertension. She has been hospitalised for 'hysteria' in the past but did not receive follow-up, outpatient treatment or psychiatric evaluation. After discontinuing her medications and leaving her family to use holy water, a religious medicine used by many Ethiopians, she was found at a nearby monastery. She was non-communicative and difficult to arouse. The patient was rushed to nearby University of Gondar Hospital where she received treatment for hepatic encephalopathy and spontaneous bacterial peritonitis. Her illness is the result of neglected tropical disease, reliance on traditional medicine as opposed to biomedical services and the poor state of psychiatric care in the developing world. PMID:27485874

  7. Plant Quantity Affects Development and Survival of a Gregarious Insect Herbivore and Its Endoparasitoid Wasp.

    Science.gov (United States)

    Fei, Minghui; Gols, Rieta; Zhu, Feng; Harvey, Jeffrey A

    2016-01-01

    Virtually all studies of plant-herbivore-natural enemy interactions focus on plant quality as the major constraint on development and survival. However, for many gregarious feeding insect herbivores that feed on small or ephemeral plants, the quantity of resources is much more limiting, yet this area has received virtually no attention. Here, in both lab and semi-field experiments using tents containing variably sized clusters of food plants, we studied the effects of periodic food deprivation in a tri-trophic system where quantitative constraints are profoundly important on insect performance. The large cabbage white Pieris brassicae, is a specialist herbivore of relatively small wild brassicaceous plants that grow in variable densities, with black mustard (Brassica nigra) being one of the most important. Larvae of P. brassicae are in turn attacked by a specialist endoparasitoid wasp, Cotesia glomerata. Increasing the length of food deprivation of newly molted final instar caterpillars significantly decreased herbivore and parasitoid survival and biomass, but shortened their development time. Moreover, the ability of caterpillars to recover when provided with food again was correlated with the length of the food deprivation period. In outdoor tents with natural vegetation, we created conditions similar to those faced by P. brassicae in nature by manipulating plant density. Low densities of B. nigra lead to potential starvation of P. brassicae broods and their parasitoids, replicating nutritional conditions of the lab experiments. The ability of both unparasitized and parasitized caterpillars to find corner plants was similar but decreased with central plant density. Survival of both the herbivore and parasitoid increased with plant density and was higher for unparasitized than for parasitized caterpillars. Our results, in comparison with previous studies, reveal that quantitative constraints are far more important that qualitative constraints on the performance of

  8. Plant Quantity Affects Development and Survival of a Gregarious Insect Herbivore and Its Endoparasitoid Wasp

    Science.gov (United States)

    Fei, Minghui; Gols, Rieta; Zhu, Feng; Harvey, Jeffrey A.

    2016-01-01

    Virtually all studies of plant-herbivore-natural enemy interactions focus on plant quality as the major constraint on development and survival. However, for many gregarious feeding insect herbivores that feed on small or ephemeral plants, the quantity of resources is much more limiting, yet this area has received virtually no attention. Here, in both lab and semi-field experiments using tents containing variably sized clusters of food plants, we studied the effects of periodic food deprivation in a tri-trophic system where quantitative constraints are profoundly important on insect performance. The large cabbage white Pieris brassicae, is a specialist herbivore of relatively small wild brassicaceous plants that grow in variable densities, with black mustard (Brassica nigra) being one of the most important. Larvae of P. brassicae are in turn attacked by a specialist endoparasitoid wasp, Cotesia glomerata. Increasing the length of food deprivation of newly molted final instar caterpillars significantly decreased herbivore and parasitoid survival and biomass, but shortened their development time. Moreover, the ability of caterpillars to recover when provided with food again was correlated with the length of the food deprivation period. In outdoor tents with natural vegetation, we created conditions similar to those faced by P. brassicae in nature by manipulating plant density. Low densities of B. nigra lead to potential starvation of P. brassicae broods and their parasitoids, replicating nutritional conditions of the lab experiments. The ability of both unparasitized and parasitized caterpillars to find corner plants was similar but decreased with central plant density. Survival of both the herbivore and parasitoid increased with plant density and was higher for unparasitized than for parasitized caterpillars. Our results, in comparison with previous studies, reveal that quantitative constraints are far more important that qualitative constraints on the performance of

  9. Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.

    Science.gov (United States)

    Tremblay, Michel G; Moss, Tom

    2016-09-01

    The extended synaptotagmins, E-Syt1, 2 and 3, are multiple C2 domain membrane proteins that are tethered to the endoplasmic reticulum and interact in a calcium dependent manner with plasma membrane phospholipids to form endoplasmic reticulum - plasma membrane junctions. These junctions have been implicated in the exchange of phospholipids between the 2 organelles. The E-Syts have further been implicated in receptor signaling and endocytosis and can interact directly with fibroblast growth factor and other cell surface receptors. Despite these multiple functions, the search for a requirement in vivo has been elusive. Most recently, we found that the genes for E-Syt2 and 3 could be inactivated without effect on mouse development, viability, fertility or morphology. We have now created insertion and deletion mutations in the last of the mouse E-Syt genes. We show that E-Syt1 is specifically expressed throughout the embryonic skeleton during the early stages of chrondrogenesis in a pattern quite distinct from that of E-Syt2 or 3. Despite this, E-Syt1 is also not required for mouse development and propagation. We further show that even the combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility in the laboratory. However, this inactivation induces an enhancement in the expression of the genes encoding Orp5/8, Orai1, STIM1 and TMEM110, endoplasmic reticulum - plasma membrane junction proteins that potentially could compensate for E-Syt loss. Given the multiple functions suggested for the E-Syts and their evolutionary conservation, our unexpected findings suggest that they may only provide a survival advantage under specific conditions that have as yet to be identified. PMID:27399837

  10. Sterol Methyl Oxidases Affect Embryo Development via Auxin-Associated Mechanisms.

    Science.gov (United States)

    Zhang, Xia; Sun, Shuangli; Nie, Xiang; Boutté, Yohann; Grison, Magali; Li, Panpan; Kuang, Susu; Men, Shuzhen

    2016-05-01

    Sterols are essential molecules for multiple biological processes, including embryogenesis, cell elongation, and endocytosis. The plant sterol biosynthetic pathway is unique in the involvement of two distinct sterol 4α-methyl oxidase (SMO) families, SMO1 and SMO2, which contain three and two isoforms, respectively, and are involved in sequential removal of the two methyl groups at C-4. In this study, we characterized the biological functions of members of the SMO2 gene family. SMO2-1 was strongly expressed in most tissues during Arabidopsis (Arabidopsis thaliana) development, whereas SMO2-2 showed a more specific expression pattern. Although single smo2 mutants displayed no obvious phenotype, the smo2-1 smo2-2 double mutant was embryonic lethal, and the smo2-1 smo2-2/+ mutant was dwarf, whereas the smo2-1/+ smo2-2 mutant exhibited a moderate phenotype. The phenotypes of the smo2 mutants resembled those of auxin-defective mutants. Indeed, the expression of DR5rev:GFP, an auxin-responsive reporter, was reduced and abnormal in smo2-1 smo2-2 embryos. Furthermore, the expression and subcellular localization of the PIN1 auxin efflux facilitator also were altered. Consistent with these observations, either the exogenous application of auxin or endogenous auxin overproduction (YUCCA9 overexpression) partially rescued the smo2-1 smo2-2 embryonic lethality. Surprisingly, the dwarf phenotype of smo2-1 smo2-2/+ was completely rescued by YUCCA9 overexpression. Gas chromatography-mass spectrometry analysis revealed a substantial accumulation of 4α-methylsterols, substrates of SMO2, in smo2 heterozygous double mutants. Together, our data suggest that SMO2s are important for correct sterol composition and function partially through effects on auxin accumulation, auxin response, and PIN1 expression to regulate Arabidopsis embryogenesis and postembryonic development. PMID:27006488

  11. High levels of inorganic nutrients affect fertilization kinetics, early development and settlement of the scleractinian coral Platygyra acuta

    Science.gov (United States)

    Lam, E. K. Y.; Chui, A. P. Y.; Kwok, C. K.; Ip, A. H. P.; Chan, S. W.; Leung, H. N.; Yeung, L. C.; Ang, P. O.

    2015-09-01

    Dose-response experiments were conducted to investigate the effects of ammonia nitrogen (NH3/NH4 +) and orthophosphate (PO4 3-) on four stages of larval development in Platygyra acuta, including fertilization, embryonic development and the survival, motility, and settlement of planula larvae. Fertilization success was reduced significantly under 200 μM NH3/NH4 + or PO4 3-. These high doses of NH3/NH4 + and PO4 - affected egg viability (or sperm viability and polyspermic block simultaneously) and polyspermic block, respectively. These results provide the first evidence to indicate the mechanisms of how inorganic nutrients might affect coral fertilization processes. For embryonic development, NH3/NH4 + at 25-200 μM caused delay in cell division after 2-h exposure and NH3/NH4 + at 100-200 μM resulted in larval death after 72 h. However, no significant differences were observed in the mobility and survivorship of either planula or competent larvae under different levels of NH3/NH4 + or PO4 3-. There was a significant (~30 %) drop in the settlement of competent larvae under the combined effect of 100 μM NH3/NH4 + and PO4 3-. The effects of elevated nutrients appeared to become more significant only on gametes or larvae undergoing active cellular activities at fertilization, early development, and settlement.

  12. Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats

    Science.gov (United States)

    Rousseau, D.; Helies-Toussaint, C.; Raederstorff, D.; Moreau, D.; Grynberg, A.

    2001-01-01

    The consequences of a dietary n-3 PUFA supply was investigated on the blood pressure (BP) increase elicited by left renal artery stenosis in rats distributed in 3 groups (n = 8) fed for 8 weeks a semi-purified diet either as control diet or enriched diets (docosahexaenoic acid, DHA, or eicosapentaenoic acid, EPA). The PUFA intake induced large alterations in heart and kidney phospholipid fatty acid profile, but did not influence body weight, cardiac hypertrophy, renal left atrophy and right hypertrophy. Within 4 weeks, BP raised from 120-180 +/- 2 mm Hg in the control group, but only to 165 +/- 3 mm Hg in the n-3 PUFA groups. After stabilization of BP in the 3 groups, the rats received a short administration of increasing dose of perindopril. The lower dose (0.5 mg/kg) moderately decreased BP only in the control group. With higher doses (1, 5 and 10 mg/kg) BP was normalized in the 3 groups, with a higher amplitude of the BP lowering effect in the control group. A moderate n-3 PUFA intake can contribute to prevent the development of peripheral hypertension in rats by a mechanism that may involve angiotensin converting enzyme.

  13. In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach

    Directory of Open Access Journals (Sweden)

    Han Lin

    2015-10-01

    Full Text Available Diethylhexyl phthalate (DEHP is one of the most widely utilized phthalate plasticizers. Previous studies have demonstrated that gestational or postnatal DEHP exposure induced adverse effects on rat brain development and function. In this study, we investigated the effects of gestational DEHP exposure on gene expression profiling in neonatal rat brain and cognitive function change at adulthood. Adult Sprague Dawley dams were orally treated with 10 or 750 mg/kg DEHP from gestational day 12 to 21. Some male pups were euthanized at postnatal day 1 for gene expression profiling, and the rest males were retained for water maze testing on postnatal day (PND 56. DEHP showed dose-dependent impairment of learning and spatial memory from PND 56 to 63. Genome-wide microarray analysis showed that 10 and 750 mg/kg DEHP altered the gene expression in the neonatal rat brain. Ccnd1 and Cdc2, two critical genes for neuron proliferation, were significantly down-regulated by DEHP. Interestingly, 750 mg/kg DEHP significantly increased Pmch level. Our study demonstrated the changed gene expression patterns after in utero DEHP exposure might partially contribute to the deficit of cognitive function at adulthood.

  14. Factors affecting the initial literacy development of urban and rural learners in the Iganga district, Uganda

    Directory of Open Access Journals (Sweden)

    Rebecca Kirunda

    2011-08-01

    Full Text Available The initial motivation for the study was data from the Ministry of Education in Uganda that suggests that in terms of academic performance, urban learners continually outperform rural schools at primary and secondary school levels (Ministry of Education 2002. At present all government examinations are written in English. However, the language in education policy in Uganda differentially stipulates the use English as medium of instruction in urban schools and the use of the mother tongue in rural schools (cf. Kyeyune 2004. Other factors which mitigate against rural learners’ successful academic performance are untrained educators, poor infrastructure and school management practices in rural schools, poverty, lack of supportive academic discourse practices, and a general lack of enthusiasm among rural parents (most of whom have very little formal education  for their children’s education. Using data from observations of selected urban and rural homes and schools in The Iganga district and field notes in the form of diary entries, the study draws on New Literacy Studies (NLS particularly the notion of literacy as social practice (Street 2001; Gee 2000; Baynham 2000, 2001, to explore the differential effect of urban and rural-based acculturation processes on the initial literacy development of learners. Finally, since 88% of Ugandans live in rural areas (Uganda Bureau of Statistics 2002, the pedagogical implications for primary schools are discussed and suggestions are made on how to establish an inclusive education system.

  15. Government perspective on current and likely future developments affecting the nuclear industry

    International Nuclear Information System (INIS)

    In October 1998 the Government published its Energy Sources White Paper, making it clear that what it wanted was an energy policy developed in a competitive market framework. The Government considers a competitive market is absolutely essential for both industrial and domestic energy users but the challenge for energy in the twenty-first century, not only in the UK but increasingly the world over, is how to deliver a competitive market and at the same time fulfil broader expectations for energy, particularly social, environmental, security and diversity objectives. Quite clearly, the nuclear industry needs to fit into this policy and the Government recognizes that it is a key player in achieving these goals. But it must be the industry itself, not the Government, that is the driver for change. The DTI believes that if the current and future economic opportunities in the nuclear industry are to be realized then there are challenges to be met in three areas: cost; waste management; and safety, environment and public confidence. This paper discusses the ways in which the industry can, with the Government's help, successfully meet these challenges. (author)

  16. Development of Quality Management Systems: How Have Disruptive Technological Innovations in Quality Management Affected Organizations?

    Directory of Open Access Journals (Sweden)

    Pasi Hellman

    2013-07-01

    Full Text Available This research investigates the history of quality and development of quality management systems. History of quality is investigated from Hammurabi’s law all the way to today’s reigning quality initiatives including ISO, Six Sigma and Lean manufacturing. In the last chapters the current state of quality management is being examined. The foresight method is also opened up and examined. The Innovator’s dilemma concept, originally presented by Clayton Christensen, is used to analyse how quality management systems have been evolved in the last 100 years. Special emphasis is placed on the US manufacturing in the 1970s and 1980s. Based on the literature, the concept of Innovator’s dilemma and the fall of US manufacturing are merged. The result is a prime example that the Innovator’s Dilemma is a universal phenomenon. The industry leader is trying to maintain its position and do everything right but still it is destined to fail. The causes and effects are being discussed in later chapters.

  17. U.S. congressional attitudes and policies affecting nuclear power development in the world

    International Nuclear Information System (INIS)

    The world future for nuclear power is even now being formed by policies and decisions of many governments and international organizations. Congressman McCormack looks to the United States for revived and stronger leadership in strengthening the web of institutions and international relations to permit the world to reap the benefits of nuclear power without a destabilizing spread of nuclear weapons. He says Congress will have a major role in shaping that nuclear future. The tensions between Congress and the executive branch that are part of the U.S. system of separation of powers can help to test and strengthen future policy on international nuclear power. The point of no return along the course of nuclear evolution is approaching and the author asks: will we press on to create an acceptable balance between benefits of nuclear power and the risk that expanded use may increase proliferation--or will we turn back toward nuclear isolationism. Mr. McCormack opts for vigorous legislative, executive and diplomatic initiatives to sustain U.S. nuclear leadership so that we can accelerate and influence world measures to prevent proliferation while developing uranium and thorium as future world energy resources

  18. Lysine and Leucine Deficiencies Affect Myocytes Development and IGF Signaling in Gilthead Sea Bream (Sparus aurata.

    Directory of Open Access Journals (Sweden)

    Sheida Azizi

    Full Text Available Optimizing aquaculture production requires better knowledge of growth regulation and improvement in diet formulation. A great effort has been made to replace fish meal for plant protein sources in aquafeeds, making necessary the supplementation of such diets with crystalline amino acids (AA to cover the nutritional requirements of each species. Lysine and Leucine are limiting essential AA in fish, and it has been demonstrated that supplementation with them improves growth in different species. However, the specific effects of AA deficiencies in myogenesis are completely unknown and have only been studied at the level of hepatic metabolism. It is well-known that the TOR pathway integrates the nutritional and hormonal signals to regulate protein synthesis and cell proliferation, to finally control muscle growth, a process also coordinated by the expression of myogenic regulatory factors (MRFs. This study aimed to provide new information on the impact of Lysine and Leucine deficiencies in gilthead sea bream cultured myocytes examining their development and the response of insulin-like growth factors (IGFs, MRFs, as well as key molecules involved in muscle growth regulation like TOR. Leucine deficiency did not cause significant differences in most of the molecules analyzed, whereas Lysine deficiency appeared crucial in IGFs regulation, decreasing significantly IGF-I, IGF-II and IGF-IRb mRNA levels. This treatment also down-regulated the gene expression of different MRFs, including Myf5, Myogenin and MyoD2. These changes were also corroborated by a significant decrease in proliferation and differentiation markers in the Lysine-deficient treatment. Moreover, both Lysine and Leucine limitation induced a significant down-regulation in FOXO3 gene expression, which deserves further investigation. We believe that these results will be relevant for the production of a species as appreciated for human consumption as it is gilthead sea bream and demonstrates

  19. Chicory (Cichorium intybus L.) and cereals differently affect gut development in broiler chickens and young pigs.

    Science.gov (United States)

    Liu, Haoyu; Ivarsson, Emma; Lundh, Torbjörn; Lindberg, Jan Erik

    2013-01-01

    Dietary fiber, resistant to host-mediated digestion in the small intestine due to lack of endogenous enzymes, impacts many facets of animal health and is associated with gut development especially in young monogastrics. Furthermore, it can be used as in-feed antibiotic alternative. Chicory (Cichorium intybus L.) forage with high content of pectin (uronic acids as building blocks) is a novel class of dietary fiber that is chemically different from cereal grains (with high content of arabinoxylans). In the present study, we investigated effects of dietary inclusion of chicory forage on digestibility, gut morphology and microbiota in broilers and young pigs. In the chicken experiment, 160 1-d old broiler chicks were fed 3 nutritionally balanced diets for 30 d including a cereal-based diet and 2 diets with part of the cereals substituted with 60 and 120 g/kg chicory forage (CF60 and CF120), whereas in the pig experiment, 18 seven-wk old Yorkshire pigs were fed 3 diets for 18 d including a cereal-based diet and 2 diets with 80 and 160 g/kg chicory forage inclusion (CF80 and CF160). Our results showed that young pigs were capable to utilize chicory forage well with higher total tract apparent digestibility (TTAD) of all fiber fractions, particularly uronic acid, compared with the control (P microbiota revealed substantial dietary effects (cereal control diet vs. chicory forage inclusion) on the relative abundance of 2 dominant bacterial phylotypes (Prevotella sp. vs. Roseburia sp.) respectively (P ingredient in diets for both pigs and chickens. PMID:24341997

  20. Lysine and Leucine Deficiencies Affect Myocytes Development and IGF Signaling in Gilthead Sea Bream (Sparus aurata)

    Science.gov (United States)

    Azizi, Sheida; Nematollahi, Mohammad Ali; Mojazi Amiri, Bagher; Vélez, Emilio J.; Lutfi, Esmail; Navarro, Isabel; Capilla, Encarnación; Gutiérrez, Joaquim

    2016-01-01

    Optimizing aquaculture production requires better knowledge of growth regulation and improvement in diet formulation. A great effort has been made to replace fish meal for plant protein sources in aquafeeds, making necessary the supplementation of such diets with crystalline amino acids (AA) to cover the nutritional requirements of each species. Lysine and Leucine are limiting essential AA in fish, and it has been demonstrated that supplementation with them improves growth in different species. However, the specific effects of AA deficiencies in myogenesis are completely unknown and have only been studied at the level of hepatic metabolism. It is well-known that the TOR pathway integrates the nutritional and hormonal signals to regulate protein synthesis and cell proliferation, to finally control muscle growth, a process also coordinated by the expression of myogenic regulatory factors (MRFs). This study aimed to provide new information on the impact of Lysine and Leucine deficiencies in gilthead sea bream cultured myocytes examining their development and the response of insulin-like growth factors (IGFs), MRFs, as well as key molecules involved in muscle growth regulation like TOR. Leucine deficiency did not cause significant differences in most of the molecules analyzed, whereas Lysine deficiency appeared crucial in IGFs regulation, decreasing significantly IGF-I, IGF-II and IGF-IRb mRNA levels. This treatment also down-regulated the gene expression of different MRFs, including Myf5, Myogenin and MyoD2. These changes were also corroborated by a significant decrease in proliferation and differentiation markers in the Lysine-deficient treatment. Moreover, both Lysine and Leucine limitation induced a significant down-regulation in FOXO3 gene expression, which deserves further investigation. We believe that these results will be relevant for the production of a species as appreciated for human consumption as it is gilthead sea bream and demonstrates the importance of

  1. Thermal conditions during juvenile development affect adult dispersal in a spider.

    Science.gov (United States)

    Bonte, Dries; Travis, Justin M J; De Clercq, Nele; Zwertvaegher, Ingrid; Lens, Luc

    2008-11-01

    Understanding the causes and consequences of dispersal is a prerequisite for the effective management of natural populations. Rather than treating dispersal as a fixed trait, it should be considered a plastic process that responds to both genetic and environmental conditions. Here, we consider how the ambient temperature experienced by juvenile Erigone atra, a spider inhabiting crop habitat, influences adult dispersal. This species exhibits 2 distinct forms of dispersal, ballooning (long distance) and rappelling (short distance). Using a half-sib design we raised individuals under 4 different temperature regimes and quantified the spiders' propensity to balloon and to rappel. Additionally, as an indicator of investment in settlement, we determined the size of the webs build by the spiders following dispersal. The optimal temperature regimes for reproduction and overall dispersal investment were 20 degrees C and 25 degrees C. Propensity to perform short-distance movements was lowest at 15 degrees C, whereas for long-distance dispersal it was lowest at 30 degrees C. Plasticity in dispersal was in the direction predicted on the basis of the risks associated with seasonal changes in habitat availability; long-distance ballooning occurred more frequently under cooler, spring-like conditions and short-distance rappelling under warmer, summer-like conditions. Based on these findings, we conclude that thermal conditions during development provide juvenile spiders with information about the environmental conditions they are likely to encounter as adults and that this information influences the spider's dispersal strategy. Climate change may result in suboptimal adult dispersal behavior, with potentially deleterious population level consequences. PMID:18974219

  2. The Zambian wildlife ranching industry: scale, associated benefits, and limitations affecting its development.

    Science.gov (United States)

    Lindsey, Peter A; Barnes, Jonathan; Nyirenda, Vincent; Pumfrett, Belinda; Tambling, Craig J; Taylor, W Andrew; t'Sas Rolfes, Michael

    2013-01-01

    The number and area of wildlife ranches in Zambia increased from 30 and 1,420 km(2) in 1997 to 177 and ∼6,000 km(2) by 2012. Wild ungulate populations on wildlife ranches increased from 21,000 individuals in 1997 to ∼91,000 in 2012, while those in state protected areas declined steeply. Wildlife ranching and crocodile farming have a turnover of ∼USD15.7 million per annum, compared to USD16 million from the public game management areas which encompass an area 29 times larger. The wildlife ranching industry employs 1,200 people (excluding jobs created in support industries), with a further ∼1,000 individuals employed through crocodile farming. Wildlife ranches generate significant quantities of meat (295,000 kg/annum), of which 30,000 kg of meat accrues to local communities and 36,000 kg to staff. Projected economic returns from wildlife ranching ventures are high, with an estimated 20-year economic rate of return of 28%, indicating a strong case for government support for the sector. There is enormous scope for wildlife ranching in Zambia due to the availability of land, high diversity of wildlife and low potential for commercial livestock production. However, the Zambian wildlife ranching industry is small and following completion of field work for this study, there was evidence of a significant proportion of ranchers dropping out. The industry is performing poorly, due to inter alia: rampant commercial bushmeat poaching; failure of government to allocate outright ownership of wildlife to landowners; bureaucratic hurdles; perceived historical lack of support from the Zambia Wildlife Authority and government; a lack of a clear policy on wildlife ranching; and a ban on hunting on unfenced lands including game ranches. For the wildlife ranching industry to develop, these limitations need to be addressed decisively. These findings are likely to apply to other savanna countries with large areas of marginal land potentially suited to wildlife ranching. PMID

  3. Developing mutant rice high in resistant starch fighting for diabetes-affected people

    International Nuclear Information System (INIS)

    Diabetes is a major socio-economic cost and is a predisposing factor for early onset coronary heart disease and peripheral vascular disease. Type II diabetes reflects a failure of blood glucose regulation, leading to sustained high blood glucose concentrations that have numbers of metabolic effects predisposing to pathology. The risk of Type II diabetes is related to diet, especially the availability of readily digested, highly refined foods and excess energy intake. In the case of diabetes, the ready digestion of carbohydrates (particularly starches) leads to a rapid rise in blood glucose and a greater demand on the pancreas for insulin to normalize concentrations. Starch that is not absorbed in the small intestine but passes into the large bowel (Resistant starch, RS) is a key protector against serious disease (including cancer) in the latter region of the intestines, being fermented by the large bowel microflora yielding short chain fatty acids (SCFA) that promote normal colonic function. Multiple approaches were suggested to obtain high amounts of resistant starch, and most of is to physically modify starch structure through processing technology. Diabetes is also increasing in the Third World and Least Developed Countries (LDCs). The current rice varieties low in resistant starch available to these individuals are not low in GI and the production of high resistant starch rices will be an attractive consumer option to this section of the population. The ability of subsistence farmers to be able sell high-RS rice lines will enable such farmers to continue to survive in those in these countries. The largest producers in the world are China and India with production at 120 and 80 million tonnes per annum respectively. The contents of RS in the hot cooked and processed rice are always below 3% by the traditionally domestic manners. This might lead to a higher glycemic index (GI) and lower butyrate content, subsequently increase the potential risk of metabolic

  4. The Zambian wildlife ranching industry: scale, associated benefits, and limitations affecting its development.

    Directory of Open Access Journals (Sweden)

    Peter A Lindsey

    Full Text Available The number and area of wildlife ranches in Zambia increased from 30 and 1,420 km(2 in 1997 to 177 and ∼6,000 km(2 by 2012. Wild ungulate populations on wildlife ranches increased from 21,000 individuals in 1997 to ∼91,000 in 2012, while those in state protected areas declined steeply. Wildlife ranching and crocodile farming have a turnover of ∼USD15.7 million per annum, compared to USD16 million from the public game management areas which encompass an area 29 times larger. The wildlife ranching industry employs 1,200 people (excluding jobs created in support industries, with a further ∼1,000 individuals employed through crocodile farming. Wildlife ranches generate significant quantities of meat (295,000 kg/annum, of which 30,000 kg of meat accrues to local communities and 36,000 kg to staff. Projected economic returns from wildlife ranching ventures are high, with an estimated 20-year economic rate of return of 28%, indicating a strong case for government support for the sector. There is enormous scope for wildlife ranching in Zambia due to the availability of land, high diversity of wildlife and low potential for commercial livestock production. However, the Zambian wildlife ranching industry is small and following completion of field work for this study, there was evidence of a significant proportion of ranchers dropping out. The industry is performing poorly, due to inter alia: rampant commercial bushmeat poaching; failure of government to allocate outright ownership of wildlife to landowners; bureaucratic hurdles; perceived historical lack of support from the Zambia Wildlife Authority and government; a lack of a clear policy on wildlife ranching; and a ban on hunting on unfenced lands including game ranches. For the wildlife ranching industry to develop, these limitations need to be addressed decisively. These findings are likely to apply to other savanna countries with large areas of marginal land potentially suited to wildlife

  5. Occurrence of depression during the postpartum period and risk factors that affect the development of the depression

    OpenAIRE

    AKTAŞ, Demet; TERZİOĞLU, Füsun

    2013-01-01

    To determine the occurrences of depression experienced by women during the postpartum period and the risk factors that affect the development of this depression. Materials and methods: The study involved 330 women who had recently given birth in a hospital in 2007. The women were contacted 3 times in total: on postpartum day 1 (face to face) and in weeks 2 and 6 (by phone). The Edinburgh Scale of Postpartum Depression (EPDS) was used as the form for collecting data. According to the EPDS, w...

  6. Early trauma and affect: the importance of the body for the development of the capacity to symbolize.

    Science.gov (United States)

    Willemsen, Hessel

    2014-11-01

    In this paper I aim to outline the importance of working clinically with affect when treating severely traumatized patients who have a limited capacity to symbolize. These patients, who suffer the loss of maternal care early in life, require the analyst to be closely attuned to the patient's distress through use of the countertransference and with significantly less attention paid to the transference. It is questionable whether we can speak of transference when there is limited capacity to form internal representations. The analyst's relationship with the patient is not necessarily used to make interpretations but, instead, the analyst's reverie functions therapeutically to develop awareness and containment of affect, first in the analyst's mind and, later, in the patient's, so that, in time, a relationship between the patient's mind and the body, as the first object, is made. In contrast to general object-relations theories, in which the first object is considered to be the breast or the mother, Ferrari (2004) proposes that the body is the first object in the emerging mind. Once a relationship between mind and body is established, symbolization becomes possible following the formation of internal representations of affective states in the mind, where previously there were few. Using Ferrari's body-mind model, two clinical case vignettes underline the need to use the countertransference with patients who suffered chronic developmental trauma in early childhood. PMID:25331507

  7. Repeated exposure of the developing rat brain to magnetic resonance imaging did not affect neurogenesis, cell death or memory function

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Changlian [Center for Brain Repair and Rehabilitation, University of Gothenburg (Sweden); Department of Pediatrics, The Third Affiliated Hospital, Zhengzhou University (China); Gao, Jianfeng [Center for Brain Repair and Rehabilitation, University of Gothenburg (Sweden); Department of Pediatrics, The Third Affiliated Hospital, Zhengzhou University (China); Department of Physiology, Henan Traditional Medical University (China); Li, Qian; Huang, Zhiheng; Zhang, Yu; Li, Hongfu [Center for Brain Repair and Rehabilitation, University of Gothenburg (Sweden); Department of Pediatrics, The Third Affiliated Hospital, Zhengzhou University (China); Kuhn, Hans-Georg [Center for Brain Repair and Rehabilitation, University of Gothenburg (Sweden); Blomgren, Klas, E-mail: klas.blomgren@neuro.gu.se [Center for Brain Repair and Rehabilitation, University of Gothenburg (Sweden); Department of Pediatric Oncology, The Queen Silvia Children' s Hospital, Gothenburg (Sweden)

    2011-01-07

    Research highlights: {yields} The effect of MRI on the developing brain is a matter of debate. {yields} Repeated exposure to MRI did not affect neurogenesis. {yields} Memory function was not affected by repeated MRI during development. {yields} Neither late gestation nor young postnatal brains were affected by MRI. {yields} Repeated MRI did not cause cell death in the neurogenic region of the hippocampus. -- Abstract: The effect of magnetic fields on the brain is a matter of debate. The objective of this study was to investigate whether repeated exposure to strong magnetic fields, such as during magnetic resonance imaging (MRI), could elicit changes in the developing rat brain. Embryonic day 15 (E15) and postnatal day 14 (P14) rats were exposed to MRI using a 7.05 T MR system. The animals were anesthetized and exposed for 35 min per day for 4 successive days. Control animals were anesthetized but no MRI was performed. Body temperature was maintained at 37 {sup o}C. BrdU was injected after each session (50 mg/kg). One month later, cell proliferation, neurogenesis and astrogenesis in the dentate gyrus were evaluated, revealing no effects of MRI, neither in the E15, nor in the P14 group. DNA damage in the dentate gyrus in the P14 group was evaluated on P18, 1 day after the last session, using TUNEL staining. There was no difference in the number of TUNEL-positive cells after MRI compared with controls, neither in mature neurons, nor in newborn progenitors (BrdU/TUNEL double-labeled cells). Novel object recognition was performed to assess memory function 1 month after MRI. There was no difference in the recognition index observed after MRI compared with the control rats, neither for the E15, nor for the P14 group. In conclusion, repeated exposure to MRI did not appear to affect neurogenesis, cell death or memory function in rats, neither in late gestation (E15-E18) nor in young postnatal (P14-P17) rats.

  8. Repeated exposure of the developing rat brain to magnetic resonance imaging did not affect neurogenesis, cell death or memory function

    International Nuclear Information System (INIS)

    Research highlights: → The effect of MRI on the developing brain is a matter of debate. → Repeated exposure to MRI did not affect neurogenesis. → Memory function was not affected by repeated MRI during development. → Neither late gestation nor young postnatal brains were affected by MRI. → Repeated MRI did not cause cell death in the neurogenic region of the hippocampus. -- Abstract: The effect of magnetic fields on the brain is a matter of debate. The objective of this study was to investigate whether repeated exposure to strong magnetic fields, such as during magnetic resonance imaging (MRI), could elicit changes in the developing rat brain. Embryonic day 15 (E15) and postnatal day 14 (P14) rats were exposed to MRI using a 7.05 T MR system. The animals were anesthetized and exposed for 35 min per day for 4 successive days. Control animals were anesthetized but no MRI was performed. Body temperature was maintained at 37 oC. BrdU was injected after each session (50 mg/kg). One month later, cell proliferation, neurogenesis and astrogenesis in the dentate gyrus were evaluated, revealing no effects of MRI, neither in the E15, nor in the P14 group. DNA damage in the dentate gyrus in the P14 group was evaluated on P18, 1 day after the last session, using TUNEL staining. There was no difference in the number of TUNEL-positive cells after MRI compared with controls, neither in mature neurons, nor in newborn progenitors (BrdU/TUNEL double-labeled cells). Novel object recognition was performed to assess memory function 1 month after MRI. There was no difference in the recognition index observed after MRI compared with the control rats, neither for the E15, nor for the P14 group. In conclusion, repeated exposure to MRI did not appear to affect neurogenesis, cell death or memory function in rats, neither in late gestation (E15-E18) nor in young postnatal (P14-P17) rats.

  9. Bisphenol A affects early bovine embryo development and metabolism that is negated by an oestrogen receptor inhibitor

    Science.gov (United States)

    Choi, Bom-Ie; Harvey, Alexandra J.; Green, Mark P.

    2016-01-01

    Increasing evidence supports an association between exposure to endocrine disruptors, such as the xenoestrogen bisphenol A (BPA), a commonly used plasticiser, and the developmental programming of offspring health. To date however animal studies to investigate a direct causal have mainly focussed on supra-environmental BPA concentrations, without investigating the effect on the early embryo. In this study we investigated the effect of acute BPA exposure (days 3.5 to 7.5 post-fertilisation) at environmentally relevant concentrations (1 and 10 ng/mL) on in vitro bovine embryo development, quality and metabolism. We then examined whether culturing embryos in the presence of the oestrogen receptor inhibitor fulvestrant could negate effects of BPA and 17β-oestradiol (E2). Exposure to BPA or E2 (10 ng/mL) decreased blastocyst rate and the percentage of transferrable quality embryos, without affecting cell number, lineage allocation or metabolic gene expression compared to untreated embryos. Notably, blastocysts exposed to BPA and E2 (10 ng/mL) displayed an increase in glucose consumption. The presence of fulvestrant however negated the adverse developmental and metabolic effects, suggesting BPA elicits its effects via oestrogen-mediated pathways. This study demonstrates that even acute exposure to an environmentally relevant BPA concentration can affect early embryo development and metabolism. These may have long-term health consequences on an individual. PMID:27384909

  10. Polybrominated diphenyl ethers affect the reproduction and development, and alter the sex ratio of zebrafish (Danio rerio)

    International Nuclear Information System (INIS)

    Polybrominated diphenyl ethers (PBDEs) have been commonly used as flame retardants and now become ubiquitous in the global environment. Using zebrafish as a model, we tested the hypothesis that PBDEs may affect the reproduction and development of fish. Zebrafish were exposed to environmentally relevant concentrations of DE-71 (a congener of PBDE commonly found in the environment) throughout their whole life cycle, and the effects of DE-71 on gonadal development, gamete quality, fertilization success, hatching success, embryonic development and sex ratio were investigated. Despite gonadal development was enhanced, reductions in spawning, fertilization success, hatching success and larval survival rate were evident, while significant increases in malformation and percentage of male were also observed in the F1 generation. Our laboratory results suggest that PBDEs may pose a risk to reproductive success and alter the sex ratio of fish in environments highly contaminated with PBDEs. -- Highlights: •Zebrafish were exposed to PBDE from eggs to adults. •An increase in Gonadal-Somatic Index and enhanced gonadal development was enhanced. •Fertilization and hatching successes were reduced, while malformation was increased. •PBDE alters sex differentiation, leading to a male biased F1 population. •Environmental relevant concentrations of PBDE threaten natural fish populations. -- PBDE reduces fertilization and hatching successes, causes malformation and leads to a male biased F1 generation in fish

  11. Growth Phase, Oxygen, Temperature, and Starvation Affect the Development of Viable but Non-culturable State of Vibrio cholerae.

    Science.gov (United States)

    Wu, Bin; Liang, Weili; Kan, Biao

    2016-01-01

    Vibrio cholerae can enter into a viable but non-culturable (VBNC) state in order to survive in unfavorable environments. In this study, we studied the roles of five physicochemical and microbiological factors or states, namely, different strains, growth phases, oxygen, temperature, and starvation, on the development of VBNC of V. cholerae in artificial sea water (ASW). Different strains of the organism, the growth phase, and oxygen levels affected the progress of VBNC development. It was found that the VBNC state was induced faster in V. cholerae serogroup O1 classical biotype strain O395 than in O1 El Tor biotype strains C6706 and N16961. When cells in different growth phases were used for VBNC induction, stationary-phase cells lost their culturability more quickly than exponential-phase cells, while induction of a totally non-culturable state took longer to achieve for stationary-phase cells in all three strains, suggesting that heterogeneity of cells should be considered. Aeration strongly accelerated the loss of culturability. During the development of the VBNC state, the culturable cell count under aeration conditions was almost 10(6)-fold lower than under oxygen-limited conditions for all three strains. The other two factors, temperature and nutrients-rich environment, may prevent the induction of VBNC cells. At 22 or 37°C in ASW, most of the cells rapidly died and the culturable cell count reduced from about 10(8) to 10(6)-10(5) CFU/mL. The total cell counts showed that cells that lost viability were decomposed, and the viable cell counts were the same as culturable cell counts, indicating that the cells did not reach the VBNC state. VBNC state development was blocked when ASW was supplied with Luria-Bertani broth (LB), but it was not affected in ASW with M9, suggesting that specific nutrients in LB may prevent the development of VBNC state. These results revealed that the five factors evaluated in this study had different roles during the progress of VBNC

  12. Growth Phase, Oxygen, Temperature and Starvation Affect the Development of Viable but Non-Culturable State of Vibrio cholerae

    Directory of Open Access Journals (Sweden)

    Bin eWu

    2016-03-01

    Full Text Available AbstractVibrio cholerae can enter into a viable but non-culturable (VBNC state in order to survive in unfavourable environments. In this study, we studied the roles of five physicochemical and microbiological factors or states, namely, different strains, growth phases, oxygen, temperature, and starvation, on the development of VBNC of V. cholerae in artificial sea water (ASW. Different strains of the organism, the growth phase, and oxygen levels affected the progress of VBNC development. It was found that the VBNC state was induced faster in V. cholerae serogroup O1 classical biotype strain O395 than in O1 El Tor biotype strains C6706 and N16961. When cells in different growth phases were used for VBNC induction, stationary-phase cells lost their culturability more quickly than exponential-phase cells, while induction of a totally non-culturable state took longer to achieve for stationary-phase cells in all three strains, suggesting that heterogeneity of cells should be considered. Aeration strongly accelerated the loss of culturability. During the development of the VBNC state, the culturable cell count under aeration conditions was almost 106-fold lower than under oxygen-limited conditions for all three strains. The other two factors, temperature and nutrients-rich environment, may prevent the induction of VBNC cells. At 22°C or 37°C in ASW, most of the cells rapidly died and the culturable cell count reduced from about 108 CFU/mL to 106–105 CFU/mL. The total cell counts showed that cells that lost viability were decomposed, and the viable cell counts were the same as culturable cell counts, indicating that the cells did not reach the VBNC state. VBNC state development was blocked when ASW was supplied with Luria-Bertani broth (LB, but it was not affected in ASW with M9, suggesting that specific nutrients in LB may prevent the development of VBNC state. These results revealed that the five factors evaluated in this study had different

  13. Effect of welding thermal cycles on the heat affected zone microstructure and toughness of multi-pass welded pipeline steels

    OpenAIRE

    Nuruddin, Ibrahim K.

    2012-01-01

    This research is aimed at understanding the effect of thermal cycles on the metallurgical and microstructural characteristics of the heat affected zone of a multi-pass pipeline weld. Continuous Cooling Transformation (CCT) diagrams of the pipeline steel grades studied (X65, X70 and X100) were generated using a thermo mechanical simulator (Gleeble 3500) and 10 mm diameter by 100 mm length samples. The volume change during phase transformation was studied by a dilatometer, this is to underst...

  14. Compromised development and survival in amphibians in reclaimed wetlands' water containing oil sands process-affected material

    International Nuclear Information System (INIS)

    When closing a mine, operators must comply with government regulations to ensure that the sites are ecologically sustainable to support endemic flora and fauna. Creating wetlands in order to age and detoxify oil sands process-affected materials (OSPM) is a common reclamation strategy. In this study, amphibians indigenous to the boreal forest ecosystem were examined to determine if they can complete their lifecycle in water from reclaimed wetlands. Wood frog (Lithobates sylvaticus) eggs were collected from a natural pond 60 km south of an oil sand mining site. Tadpoles were raised in 1 of 6 water treatments refreshed every two days. The 2 reference water treatments included aged tap water and water from natural wetlands. The remaining 4 water treatments were from research wetlands on Syncrude and Suncor lease sites. Of the 120 tadpoles raised per water treatment, there was no significant difference in growth, development, or survival rates between the aged tap water and reference wetland water, but the fastest growth, development, and highest survival rates occurred in the two reference groups. There was a pronounced difference among the 4 treatment groups from Suncor and Syncrude reclamation sites. Survival was high in 3 of the water treatments from Syncrude and Suncor sites, but development rates were considerably reduced. Tadpoles that do not metamorphose before winter do not survive. It was therefore concluded that delayed development in tadpoles poses a serious risk to population stability in OSPM-containing wetlands.

  15. Development of alternative interpretations: The story of an orphaned boy affected by HIV and AIDS and father abandonment

    Directory of Open Access Journals (Sweden)

    Juanita Meyer

    2014-08-01

    Full Text Available This article elaborated specifically on the research journey in arriving at the development of an alternative narrative, which points beyond the local community, with reference to a broader study which aimed at addressing uncertainties about the type and nature of the relationship between HIV and AIDS and adolescent male orphans affected by this disease and all its aspects, such as poverty, exposure to crime and stigmatisation and lack in parental figures, more specifically the lack of the father figure. Subsequently, this study aimed at dissecting the orphan�s life experiences in the midst of HIV and AIDS and how these experiences will influence his sexual and power relations with women and his role as future father and husband, in the absence of a father figure. The researcher wanted to explore ways in which these past and future narratives influence or affect the male orphan�s view of and relationship with God and assess whether it is it just this view of and relationship with God that influence and affect his relationship with his past narrative and writing of his future narratives. This article described and explained the research process as it utilised the epistemological viewpoints of a postfoundational notion of practical theology and the methodological tools of the seven movements of a postfoundational practical theology. With the use of the metaphor of Tree of Life and the David narrative, the researcher journeyed with the co-researchers (i.e. the children who took part in this research in the construction of a preferred alternative narrative, which, in turn, functions as a guiding metaphor, for aspiring to the future and living their lives in a preferred and satisfying manner. This article concluded with an alternative narrative as developed by one of the co-researchers, as an example of how these theoretical viewpoints can be used in praxis in developing alternative narratives which frees the persons from the constraints of a

  16. Nomothetic outcome assessment in counseling and psychotherapy: Development and preliminary psychometric analyses of the Depression/Anxiety Negative Affect Scale

    Directory of Open Access Journals (Sweden)

    Scott T. Meier

    2012-12-01

    Full Text Available Negative affect (NA plays a significant role in the initiation, persistence, and response to psychotherapy of many client problems (Moses & Barlow, 2006. This report describes the development of a brief NA measure, the Depression/Anxiety Negative Affect (DANA scale, and preliminary analyses of its psychometric properties. An initial pool of DANA items was selected on the basis of a review of relevant literature about emotion science and counseling outcomes, related tests, and feedback from psychotherapists as part of a pilot test. The DANA was evaluated in two representative clinical samples where psychotherapists produced a total of 363 session ratings with 81 clients. DANA scores evidenced adequate internal consistency, evidence of convergent and discriminant validity, and sensitivity to change over the course of psychotherapy. Effect sizes (ES of DANA scores consistently equaled or exceeded the average ES of .68 found for scales assessing the outcomes of counseling and psychotherapy in meta-analytic studies (Smith & Glass, 1977. ESs greater than 1 were found on DANA variables for clients whose therapists rated them as experiencing, rather than avoiding, NA.

  17. Altered Disrupted-in-Schizophrenia-1 Function Affects the Development of Cortical Parvalbumin Interneurons by an Indirect Mechanism.

    Science.gov (United States)

    Borkowska, Malgorzata; Millar, J Kirsty; Price, David J

    2016-01-01

    Disrupted-in-Schizophrenia-1 (DISC1) gene has been linked to schizophrenia and related major mental illness. Mouse Disc1 has been implicated in brain development, mainly in the proliferation, differentiation, lamination, neurite outgrowth and synapse formation and maintenance of cortical excitatory neurons. Here, the effects of two loss-of-function point mutations in the mouse Disc1 sequence (Q31L and L100P) on cortical inhibitory interneurons were investigated. None of the mutations affected the overall number of interneurons. However, the 100P, but not the 31L, mutation resulted in a significant decrease in the numbers of interneurons expressing parvalbumin mRNA and protein across the sensory cortex. To investigate role of Disc1 in regulation of parvalbumin expression, mouse wild-type Disc-1 or the 100P mutant form were electroporated in utero into cortical excitatory neurons. Overexpression of wild-type Disc1 in these cells caused increased densities of parvalbumin-expressing interneurons in the electroporated area and in areas connected with it, whereas expression of Disc1-100P did not. We conclude that the 100P mutation prevents expression of parvalbumin by a normally sized cohort of interneurons and that altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons. PMID:27244370

  18. Interaction Between Syndromic and Non-Syndromic Factors Affecting Speech and Language Development in Treacher-Collins Syndrome

    Directory of Open Access Journals (Sweden)

    Marziyeh Poorjavad

    2011-09-01

    Full Text Available Background: Treacher-Collins syndrome is a congenital craniofacial disorder with multiple anomalies. This syndrome affects the maxilla, mandible, eyes, middle and outer ears, and soft palate. Conductive hearing loss due to the deformities of the middle and external ears is prevalent. The characteristics of this syndrome include multiple and serious threats to normal communication development in children. In this study, speech and language features of a Persian speaking child with this syndrome are presented.Case: The case was an 8-year old girl with Treacher-Collins syndrome and bilateral moderate conductive hearing loss due to atretic canal. In language and speech assessments, moderate hypernasality, numerous compensatory errors and morphosyntactic deficits were observed. There were 13 phonemes that were incorrectly produced at least in one position. Besides, she used 22 types of phonological processes that were abnormal and disappear before the age of three in normal Persian speaking children.Conclusion: Moderate hearing loss, velopharyngeal incompetency, malocclusion and dental anomalies, attention deficit/hyperactivity disorder (ADHD and environmental factors resulted in severe speech and language disorders in this case. These disorders affected her academic performance as well. Moderate hypernasality, numerous compensatory errors, and excessive and abnormal use of phonological processes were not presented as prevalent characteristics of Treacher-Collins syndrome in other resources.

  19. Luminal epithelium in endometrial fragments affects their vascularization, growth and morphological development into endometriosis-like lesions in mice

    Directory of Open Access Journals (Sweden)

    Dilu Feng

    2014-02-01

    Full Text Available In endometriosis research, endometriosis-like lesions are usually induced in rodents by transplantation of isolated endometrial tissue fragments to ectopic sites. In the present study, we investigated whether this approach is affected by the cellular composition of the grafts. For this purpose, endometrial tissue fragments covered with luminal epithelium (LE+ and without luminal epithelium (LE− were transplanted from transgenic green-fluorescent-protein-positive (GFP+ donor mice into the dorsal skinfold chamber of GFP− wild-type recipient animals to analyze their vascularization, growth and morphology by means of repetitive intravital fluorescence microscopy, histology and immunohistochemistry during a 14-day observation period. LE− fragments developed into typical endometriosis-like lesions with cyst-like dilated endometrial glands and a well-vascularized endometrial stroma. In contrast, LE+ fragments exhibited a polypoid morphology and a significantly reduced blood perfusion after engraftment, because the luminal epithelium prevented the vascular interconnection with the microvasculature of the surrounding host tissue. This was associated with a markedly decreased growth rate of LE+ lesions compared with LE− lesions. In addition, we found that many GFP+ microvessels grew outside the LE− lesions and developed interconnections to the host microvasculature, indicating that inosculation is an important mechanism in the vascularization process of endometriosis-like lesions. Our findings demonstrate that the luminal epithelium crucially affects the vascularization, growth and morphology of endometriosis-like lesions. Therefore, it is of major importance to standardize the cellular composition of endometrial grafts in order to increase the validity and reliability of pre-clinical rodent studies in endometriosis research.

  20. Development of Lightning Simulator

    CERN Document Server

    Uehara, Shigeki

    2014-01-01

    In this work we have developed a lightning simulator. Reproducing the light of lightning, we adopted seven waveforms that contains two light waveforms and five current waveforms of lightning. Furthermore, the lightning simulator can calibrate the color of the simulated light output based on a correlated color temperature (CCT). The CCT of the simulated light can range over from $4269$ K to $15042$ K. It is considered that the lightning simulator is useful for the test light source of the optical/image sensor of the lightning observation. Also for science education (e.g. physics education and earth science education etc.), the lightning simulator is available. Especially, the temporal change can be slowly seen by expanding the time scale from microsecond to second.

  1. The DnaJ-Like Zinc Finger Domain Protein PSA2 Affects Light Acclimation and Chloroplast Development in Arabidopsis thaliana.

    Science.gov (United States)

    Wang, Yan-Wen; Chen, Si-Ming; Wang, Wei-Jie; Huang, Xing-Qi; Zhou, Chang-Fang; Zhuang, Zhong; Lu, Shan

    2016-01-01

    The biosynthesis of chlorophylls and carotenoids and the assembly of thylakoid membranes are critical for the photoautotrophic growth of plants. Different factors are involved in these two processes. In recent years, members of the DnaJ-like zinc finger domain proteins have been found to take part in the biogenesis and/or the maintenance of plastids. One member of this family of proteins, PSA2, was recently found to localize to the thylakoid lumen and regulate the accumulation of photosystem I. In this study, we report that the silencing of PSA2 in Arabidopsis thaliana resulted in variegated leaves and retarded growth. Although both chlorophylls and total carotenoids decreased in the psa2 mutant, violaxanthin, and zeaxanthin accumulated in the mutant seedlings grown under growth condition. Lower levels of non-photochemical quenching and electron transport rate were also found in the psa2 mutant seedlings under growth condition compared with those of the wild-type plants, indicating an impaired capability to acclimate to normal light irradiance when PSA2 was silenced. Moreover, we also observed an abnormal assembly of grana thylakoids and poorly developed stroma thylakoids in psa2 chloroplasts. Taken together, our results demonstrate that PSA2 is a member of the DnaJ-like zinc finger domain protein family that affects light acclimation and chloroplast development. PMID:27047527

  2. The influence of social psychological factors on behaviour, stress and dose in Chernobyl affected areas

    International Nuclear Information System (INIS)

    During the 12 years since the Chernobyl nuclear accident, people in the affected areas have lived day to day with the risks of radiation. During these 12 years many countermeasures have been applied to minimise dose and thus reduce the threat to the health of the affected populations. Some of these countermeasures are aimed at changing daily life; for example, advice and restrictions on behaviours relating to the forest, consumption of forest produce and the consumption of private milk. In order to be effective, these countermeasures require action, or compliance, on the part of the affected populations. How have people in these areas responded to this risk and to the countermeasures employed to minimise the risk? A number of social psychological factors may be involved in peoples responses to this situation, including their perceptions of threat, the perceived costs and benefits of the behaviours involved, and the influence of other people. We examine the influence of these various social psychological factors on compliance behaviour, dose, and stress related health through a survey of people in the affected areas using quantitative questionnaire measures. SPARPA or Social psychological aspects of radiation protection after accidents, is a European Commission-sponsored project (F14C-CT96-0010) involving U. Surrey, Symlog and NRPB as well as partners in the CIS. Specific objectives include: to characterise, using quantitative methods, the nature and psychological impact of countermeasures and the influence of behaviour on dose, and to develop, guidance on the implementation of countermeasures, taking account of the social and psychological context. (authors)

  3. Conceptual differences between existing and advanced reactors and criteria affecting the development of new types of nuclear power plants world-wide

    International Nuclear Information System (INIS)

    A comparison of the nuclear safety principles and the design and operating parameters between existing and advanced reactors is presented, and criteria affecting the development of new types of nuclear reactor are outlined

  4. Prematurity and low birth weight as risk factors for the development of affective disorder, especially depression and schizophrenia: A register study

    DEFF Research Database (Denmark)

    JK, Larsen; Bendsen, BB; Foldager, Leslie; Munk-Jørgensen, Povl

    2010-01-01

    Background: The present study examined whether low birth weight, prematurity or low birth weight adjusted for gestational age are risk factors for the subsequent development of affective disorder, especially depression. Methods: A population-based case-control design was applied to the Danish...... adjustment for low birth weight. Conclusion: Prematurity and low birth weight were found to be risk factors for subsequent development of affective disorder (especially depression) and schizophrenia....

  5. Development of an auditory emotion recognition function using psychoacoustic parameters based on the International Affective Digitized Sounds.

    Science.gov (United States)

    Choi, Youngimm; Lee, Sungjun; Jung, SungSoo; Choi, In-Mook; Park, Yon-Kyu; Kim, Chobok

    2015-12-01

    The purpose of this study was to develop an auditory emotion recognition function that could determine the emotion caused by sounds coming from the environment in our daily life. For this purpose, sound stimuli from the International Affective Digitized Sounds (IADS-2), a standardized database of sounds intended to evoke emotion, were selected, and four psychoacoustic parameters (i.e., loudness, sharpness, roughness, and fluctuation strength) were extracted from the sounds. Also, by using an emotion adjective scale, 140 college students were tested to measure three basic emotions (happiness, sadness, and negativity). From this discriminant analysis to predict basic emotions from the psychoacoustic parameters of sound, a discriminant function with overall discriminant accuracy of 88.9% was produced from training data. In order to validate the discriminant function, the same four psychoacoustic parameters were extracted from 46 sound stimuli collected from another database and substituted into the discriminant function. The results showed that an overall discriminant accuracy of 63.04% was confirmed. Our findings provide the possibility that daily-life sounds, beyond voice and music, can be used in a human-machine interface. PMID:25319038

  6. Perinatal exposure to bisphenol-A inhibits synaptogenesis and affects the synaptic morphological development in offspring male mice.

    Science.gov (United States)

    Xu, Xiaohong; Xie, Lingdan; Hong, Xing; Ruan, Qin; Lu, Hongfei; Zhang, Qin; Zhang, Guangxia; Liu, Xingyi

    2013-05-01

    Our previous study indicated that perinatal exposure to low-dose BPA, one of the most common environmental endocrine disrupters, alters behavioral development in offspring mice. Given that synaptic structure of the hippocampus is closely related to behaviors, in the present study, we examined the effects of perinatal exposure to BPA (0.04, 0.4, and 4.0 mg kg(-1) day(-1)) on the synaptic density and the synaptic structural modification of pyramidal cells in hippocampus region CA1 and the expressions of synaptic proteins such as synapsin I and PSD-95 and glutamate NMDA and AMPA receptors in male offspring mice on postnatal day (PND) 14, 21, and 56. The results of electron microscope measurement showed that BPA significantly reduced the numeric synaptic density and altered the structural modification of synaptic interface of pyramidal cells with the enlarged synaptic cleft, the shortened active zone, and the thinned postsynaptic density (PSD) on PND 14, 21, and 56 and the increased curvature of synaptic interface on PND 14 and 21. Further analyses of Western blot indicated that BPA markedly reduced the levels of synapsin I and PSD-95 on PND 14, 21, and 56 and down-regulated NMDA receptor subunit NR1 and AMPA receptor subunit GluR1 during development and young adulthood. These results suggest that perinatal exposure to low level of BPA inhibits synaptogenesis and affects synaptic structural modification after birth. The reduced expressions of synaptic proteins synapsin I and PSD-95 and glutamate NMDA and AMPA receptors may be involved in the negative changes in the synaptic plasticity. PMID:23490186

  7. SGO1 maintains bovine meiotic and mitotic centromeric cohesions of sister chromatids and directly affects embryo development.

    Directory of Open Access Journals (Sweden)

    Feng-Xia Yin

    Full Text Available Shugoshin (SGO is a critical factor that enforces cohesion from segregation of paired sister chromatids during mitosis and meiosis. It has been studied mainly in invertebrates. Knowledge of SGO(s in a mammalian system has only been reported in the mouse and Hela cells. In this study, the functions of SGO1 in bovine oocytes during meiotic maturation, early embryonic development and somatic cell mitosis were investigated. The results showed that SGO1 was expressed from germinal vesicle (GV to the metaphase II stage. SGO1 accumulated on condensed and scattered chromosomes from pre-metaphase I to metaphase II. The over-expression of SGO1 did not interfere with the process of homologous chromosome separation, although once separated they were unable to move to the opposing spindle poles. This often resulted in the formation of oocytes with 60 replicated chromosomes. Depletion of SGO1 in GV oocytes affected chromosomal separation resulting in abnormal chromosome alignment at a significantly higher proportion than in control oocytes. Knockdown of SGO1 expression significantly decreased the embryonic developmental rate and quality. To further confirm the function(s of SGO1 during mitosis, bovine embryonic fibroblast cells were transfected with SGO1 siRNAs. SGO1 depletion induced the premature dissociation of chromosomal cohesion at the centromere and along the chromosome arm giving rise to abnormal appearing mitotic patterns. The results of this study infer that SGO1 is involved in the centromeric cohesion of sister chromatids and chromosomal movement towards the spindle poles. Depletion of SGO1 causes arrestment of cell division in meiosis and mitosis.

  8. Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord.

    Science.gov (United States)

    Huang, L; Xian, Q; Shen, N; Shi, L; Qu, Y; Zhou, L

    2015-08-20

    The arrival and refinement of corticospinal afferents are likely to influence the maturation of the spinal cord and sensory-motor networks. To understand this better, we studied the revision of monosynaptic muscle afferents, the expression of activity-related genes, neurotrophins and their receptors in the cervical spinal cord from postnatal day (P) 0 to 21. We compared control and Celsr3|Emx1 mice, in which corticospinal axons never develop. The corticospinal tract (CST), labeled by anti-protein kinase C gamma (PKCγ) antibody in the dorsal funiculus, increased gradually in the control, but was never visible in the mutant. Using anti-parvalbumin and choline acetyltransferase double immunostaining, close contacts between proprioceptive afferent fibers and spinal motor neurons appeared at P0 and were gradually eliminated thereafter, with no difference between control and mutant mice. In both genotypes, the number of parvalbumin-positive interneurons increased similarly from P7 to P21, and a comparable upregulation of c-Jun protein was seen at P7. Contrary to control samples, in which ciliary neurotrophic factor (CNTF) protein levels increased from P0 to P7 and gradually decreased after P14, CNTF concentrations were time-invariant in mutant samples. The dynamic profile of neurotrophin-3 (NT3) expression was also moderately affected in mutant mice. In control spinal cord, NT3 was increased at P7 and decreased at P14, but remained more stable in mutant samples. In contrast, expression profiles of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase (Trk) B, TrkC, p75 neurotrophin receptor (p75(NTR)) and glial cell-line-derived neurotrophic factor (GDNF) were similar in both genotypes. In conclusion, with the possible exception of CNTF and NT3 expression, most events that accompany maturation of the spinal cord appear largely independent of corticospinal inputs. PMID:26079333

  9. Diethylstilbestrol at environmental levels affects the development of early life stage and target gene expression in Japanese Medaka (Oryzias latipes).

    Science.gov (United States)

    Lei, Bingli; Peng, Wei; Li, Wei; Yu, Yingxin; Xu, Jie; Wang, Yipei

    2016-04-01

    In this study, the biologic effects of DES on the early life and adult life stages of Japanese medaka (Oryzias latipes) were evaluated. At the early life stage, the fertilized eggs were exposed to 1-1000 ng/L diethylstilbestrol (DES) for 15 days and the hatched larvae were continually exposed to the same concentrations for an additional 25 days. Significant adverse effects on hatchability, time to hatching and mortality rate occurred at DES concentrations of 100 and 1000 ng/L, while the abnormality (scoliosis and abdominal swelling) rate was significantly increased at 10 ng/L and above. After exposure, the fish were maintained in charcoal-dechlorinated tap water for a further 30 days. Only the male gonadosomatic index (GSI) at 1000 ng/L was significantly increased. At concentrations greater than 1 ng/L, estrogen receptor α (ERα) mRNA in both sexes and vitellogenin-I (Vtg-I) mRNA in males were significantly down-regulated; while Vtg-I mRNA in females was significantly up-regulated. When sexually mature medaka were exposed to 10 and 1000 ng/L DES for 21 days, only the GSI in females was significantly decreased at 1000 ng/L. At 10 and 1000 ng/L, ERα mRNA in both sexes was significantly down-regulated, while Vtg-I mRNA in males was significantly up-regulated. These findings showed that DES at the environmental concentration of 10 ng/L can affect the early life stage development of medaka and alter liver ERα and Vtg-I gene expression. Therefore, if we only focused on these sensitive toxicity endpoints such as ERα and Vtg-I mRNA expression, DES has a strong estrogenic effect on Japanese medaka. PMID:26908245

  10. Development of an epidemiological index for primary anterior teeth affected by erosion and prevalence of dental erosion in pre-school Saudi children

    OpenAIRE

    Al-Malik, M.

    2000-01-01

    Erosion affects both dentitions but has proved difficult to measure. It has been thought to affect children who are less susceptible to caries but previous studies have been confined to countries where caries prevalence is low. The aims of this study were first, to develop and then investigate the validity of an index to measure erosion in primary teeth. Secondly, to determine the prevalence of erosion in primary incisors amongst kindergarten children in Jeddah and its relat...

  11. Analysis Effect Development Of The Money Market And Fundamental’s Factors Affect The Stock Price Of Banking In Indonesia

    OpenAIRE

    Pelsa, Ibnu

    2014-01-01

    This research aimed to determine the effect of fundamental’s factors and systematic rates to the stock price of bank on the list of LQ 45 in Indonesia. Fundamental analysis is a picture of the bank company’s performance based on fundamental factors. Systematic Rates (BIRATE and JIBOR) is a rates that affects the market price of the existing shares on the stock exchange. Fundamental analysis is the form of financial ratios, BIRate and JIBOR are identified variables could affect the stock pric...

  12. [Affective dependency].

    Science.gov (United States)

    Scantamburlo, G; Pitchot, W; Ansseau, M

    2013-01-01

    Affective dependency is characterized by emotional distress (insecure attachment) and dependency to another person with a low self-esteem and reassurance need. The paper proposes a reflection on the definition of emotional dependency and the confusion caused by various denominations. Overprotective and authoritarian parenting, cultural and socio-environmental factors may contribute to the development of dependent personality. Psychological epigenetic factors, such as early socio-emotional trauma could on neuronal circuits in prefronto-limbic regions that are essential for emotional behaviour.We also focus on the interrelations between dependent personality, domestic violence and addictions. The objective for the clinician is to propose a restoration of self-esteem and therapeutic strategies focused on autonomy. PMID:23888587

  13. Maternal Work Behavior under Welfare Reform: How Does the Transition from Welfare to Work Affect Child Development? JCPR Working Paper.

    Science.gov (United States)

    Dunifon, Rachel; Kalil, Ariel; Danziger, Sandra K.

    Using data from a longitudinal sample of former and current welfare recipients in Michigan spanning 1997 through 1999, the Womens Employment Study, this analysis examined how transitions from welfare to work affect parenting behavior and child behavior problems. Researchers used a fixed-effects regression design to control for all time-invariant…

  14. Communicative-Based Curriculum Innovations between Theory and Practice: Implications for EFL Curriculum Development and Student Cognitive and Affective Change

    Science.gov (United States)

    Shawer, Saad

    2010-01-01

    This qualitative study examines the influence of teacher conceptualisations of communicative language teaching on their actual classroom practice and student cognitive and affective change. The qualitative paradigm underpinned this research at the levels of ontology (multiple teacher realities), epistemology (interaction with, rather than…

  15. Estimation of the minimum dose required to measure ventricular width in follow-up cranial computed tomography (CCT) in children with hydrocephalus

    Energy Technology Data Exchange (ETDEWEB)

    Kirchhof, K. [Universitaetsklinikum Dresden (Germany). Inst. und Poliklinik fuer Radiologische Diagnostik; Wohlgemuth, W.A.; Berlis, A. [Klinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie

    2010-12-15

    Purpose: To estimate the minimum dose needed at follow-up cranial computed tomography (CCT) to reliably determine ventricular width in children with hydrocephalus. Materials and Methods: For the study, a phantom was created using the calvarium of an infant which was filled with gelatin and the shaped inner cones of two carrots serving as lateral ventricles. The phantom was scanned ten times with two multi-slice CTs (LightSpeed Ultra, GE, and Somatom Sensation, Siemens), using a tube current of 400, 350, 300, 250, 200, 150, and 100 mA, and a tube voltage of 140, 120, 100, and 80 kV. The width of both lateral ventricles was measured at 4 sites. The values derived from scans performed at 380 / 400 mA and 140 kV (LightSpeed/Somatom) served as a reference. Measurements scored 1 point if they did not differ by more than 0.5 mm from the reference values. Results: The radiation dose can be reduced from 61.0 mGy to 9.2 mGy (15.1 %) with LightSpeed and from 55.0 mGy to 8.0 mGy (14.6 %) with Somatom without impairing the reliability of ventricular width measurements. However, in the case of both scanners, certain combinations of tube voltage and current yielded less reliable measurements although the dose was higher and the pixel noise was lower. Conclusion: There is no single cut-off dose or setting for tube voltage and current which guarantees reliable ventricular width measurements with the least radiation exposure for both scanners. As a guideline, it is safe to use the standard protocols with a reduced tube current of 100 kV. (orig.)

  16. Digital Divide as It Affects the Development of E-Commerce in Nigeria: A Qualitative Research Study

    Science.gov (United States)

    Omorogbe, Cyril Amadin Matthew

    2012-01-01

    Several studies have shown that information and communications technology (ICT) is important in economic and business development. The advent and rapid development of ICT have not helped in bridging the technological gap between developing countries and advanced countries. In fact, there is an Internet access gap between developed and developing…

  17. Mediating Role of Affective Commitment in HRM Practices and Turnover Intention Relationship: A Study in a Developing Context

    Directory of Open Access Journals (Sweden)

    Kawsar Ahmmed

    Full Text Available The present study was designed to examine the dimensions of HRM practices that may cause faculty turnover decision among the private university faculty members in Bangladesh. The role of affective commitment as the mediator in the proposed relationship was also investigated. A total of 317 faculty members of the private universities participated, completed and returned the questionnaire which represented 57% response rate of the study. Multiple regression analyses were used to test the hypotheses of the study. The results of the study revealed that out of six HRM practices used in this study three were found highly significant and negatively related to turnover intention. The study also found that affective commitment mediates the proposed relationship between HRM practices and turnover intention. Limitations and suggestions for future research are forwarded.

  18. How industry change has affected European airlines : Development of profitability and capital structure year 2000-2008

    OpenAIRE

    Hourani, Rayan; Helander, Anna

    2009-01-01

    Background: The airline industry of today functions in a very intense and competitive market and is also very sensitive to change. Over the last years the airline industry has changed and been affected drastically. Factors like sudden shocks, such as the terrorist attacks of September 11th in 2001 and the SARS (Severe Acute Respiratory Syndrome) phenomenon in China 2003, change in macroeconomic factors, such as GDP growth in different regions, changes in the oil price and fluctuations in exch...

  19. Does household air pollution from cooking fires affect infant neurodevelopment? Developing methods in the NACER pilot study in rural Guatemala

    OpenAIRE

    Dr. Lisa M Thompson, PhD; Guinevere Valencia-Moscoso, MS; Renée Asteria Peñaloza, MPH; Anaité Díaz Artiga, MPH; Eduardo Canúz, BS; Kirk R Smith, PhD; S Katharine Hammond, PhD

    2014-01-01

    Background: Worldwide, 3 billion people are exposed to household air pollution from cooking fires. One of the top two risk factors among neonates, household air pollution greatly affects neonatal morbidity and mortality. In low-resource countries, neurodevelopmental impairments are often not identified during the neonatal period, leading to permanent disability. No published studies have examined the effect of household air pollution exposures on neurodevelopmental impairments in infants. The...

  20. Developing a functional model for cities impacted by a natural hazard: application to a city affected by flooding

    OpenAIRE

    Bambara, G.; Peyras, L.; Felix, H.; Serre, D.

    2015-01-01

    The experience feedback on a crisis that hit a city is frequently used as a "recollection" tool. To capitalize information about an experience feedback from the cities that have been affected by a natural hazard, the authors propose in this study a functional model to model scenarios of city crises. In this model, the city, considered as a complex system, was modelled using a functional analysis method. Based on such modelling, two risk analysis methods (Failure Mode and Eff...

  1. Assessment of Nutritional Status and Developing Low Cost Recipes for Malnourished Children in the Tsunami affected Areas of Nagapattinam District

    OpenAIRE

    Raja lakshmi. J; Sheila John

    2011-01-01

    Background: The tsunami disaster in the Indian Ocean is one of the worst natural disasters in the modern times. The grief and worry created by the disaster has affected the health status of women and children. Malnutrition and ill health are major problems. This study investigated the nutritional status of the children and provided a nutrition education program for the mothers. Aims: To study the demographic profile, dietary habits, anthropometric measurements, clinical assessment...

  2. Moderate Increase of Mean Daily Temperature Adversely Affects Fruit Set of Lycopersicon esculentum by Disrupting Specific Physiological Processes in Male Reproductive Development

    OpenAIRE

    Sato, S; Kamiyama, M; Iwata, T.; Makita, N; Furukawa, H.; Ikeda, H

    2006-01-01

    • Background and Aims Global warming is gaining significance as a threat to natural and managed ecosystems since temperature is one of the major environmental factors affecting plant productivity. Hence, the effects of moderate temperature increase on the growth and development of the tomato plant (Lycopersicon esculentum) were investigated.

  3. The social biofeedback theory of parental affect-mirroring: the development of emotional self-awareness and self-control in infancy.

    Science.gov (United States)

    Gergely, G; Watson, J S

    1996-12-01

    The authors present a new theory of parental affect-mirroring and its role in the development of emotional self-awareness and control in infancy. It is proposed that infants first become sensitised to their categorical emotion-states through a natural social biofeedback process provided by the parent's 'marked' reflections of the baby's emotion displays during affect-regulative interactions. They argue that this sensitisation process is mediated (similarly to that of adult biofeedback training) by the mechanism of contingency-detection and maximising. Apart from sensitisation, affect-mirroring serves three further developmental functions: (1) it contributes to the infant's state-regulation; (2) it leads to the establishment of secondary representations that become associated with the infant's primary procedural affect-states providing the cognitive means for accessing and attributing emotions to the self; (3) it results in the development of a generalised communicative code of "marked' expressions characterised by the representational functions of referential decoupling, anchoring and suspension of realistic consequences. They consider the clinical implications of our theory, relating it to current psychodynamic approaches to the functions of parental affect-mirroring. Using their model they identify various types of deviant mirroring styles and speculate about their developmental consequences. Finally, they discuss what role their social biofeedback model may play as a mediating mechanism in the therapeutic process. PMID:9119582

  4. Affect of Early-Life Oxygen Exposure on Proper Lung Development and Response to Respiratory Viral Infections

    Directory of Open Access Journals (Sweden)

    William G. Domm

    2015-08-01

    Full Text Available Children born preterm often exhibit reduced lung function and increased severity of response to respiratory viruses, suggesting that premature birth has compromised proper development of the respiratory epithelium and innate immune defenses. Increasing evidence suggests that premature birth promotes aberrant lung development likely due to the neonatal oxygen transition occurring before pulmonary development has matured. Given that preterm infants are born at a point of time where their immune system is also still developing, early-life oxygen exposure may also be disrupting proper development of innate immunity. Here we review current literature in hopes of stimulating research that enhances understanding of how the oxygen environment at birth influences lung development and host defense. This knowledge may help identify those children at risk for disease and ideally culminate in the development of novel therapies that improve their health.

  5. Factors Affecting Psychosocial and Motor Development in 3-Year-Old Children Who Are Deaf or Hard of Hearing.

    Science.gov (United States)

    Leigh, Greg; Ching, Teresa Y C; Crowe, Kathryn; Cupples, Linda; Marnane, Vivienne; Seeto, Mark

    2015-10-01

    Previous research has shown an association between children's development of psychosocial and motor skills. This study evaluated the development of these skills in 301 three-year-old deaf and hard of hearing children (M: 37.8 months) and considered a range of possible predictors including gender, birth weight, age at first fitting with hearing devices, hearing device used, presence of additional disabilities, severity of hearing loss, maternal education, socio-economic status (SES), language ability, and communication mode. Caregivers reported on children's development using the Child Development Inventory (CDI). On average, both psychosocial and motor development quotients were within the typical range for hearing children, with large individual differences. There was a positive correlation between language ability and both social and motor development, and also between social and motor development. Age at first fitting of hearing aids (as an indicator of age at identification of hearing loss), SES, degree of hearing loss, and maternal education were not significant predictors of social skill or motor development, whereas presence of additional disabilities and birth weight were. Girls performed better than boys on all but the Gross Motor subscale of the CDI. Children with hearing aids tended to perform better than those with cochlear implants on the Gross Motor subscale. PMID:26209447

  6. Market-oriented new product development: How can a means-end chain approach affect the process?

    DEFF Research Database (Denmark)

    Søndergaard, Helle Alsted

    2005-01-01

    Purpose - Aims to ascertain whether a well-known theory within consumer research - a means-end chain (MEC) - can be used as a catalyst to achieve market oriented product development. Design/methodology/approach - Describes a case study, involving a Danish food manufacturer, where a MEC approach was...... resukts also indicate that MEC data are most valuable to the team in the early stages of the development process and that lack of a learning orientation may inhibit the effects of a MEC approach. Originality/value - The MEC approach shows clear advantages for market oriented product development....... introduced to a cross-functional development team at two different stages of the development process. Findings - Results show that MEC data is perceived as a good way of gaining knowledge about consumers; that the information serves well as the basis of discussions and for keeping project goals fixed. The...

  7. How does socioeconomic development affect COPD mortality? An age-period-cohort analysis from a recently transitioned population in China.

    Directory of Open Access Journals (Sweden)

    Jing Chen

    Full Text Available BACKGROUND: Chronic obstructive pulmonary disease (COPD is a leading cause of death, particularly in developing countries. Little is known about the effects of economic development on COPD mortality, although economic development may potentially have positive and negative influences over the life course on COPD. We took advantage of a unique population whose rapid and recent economic development is marked by changes at clearly delineated and identifiable time points, and where few women smoke, to examine the effect of macro-level events on COPD mortality. METHODS: We used Poisson regression to decompose sex-specific COPD mortality rates in Hong Kong from 1981 to 2005 into the effects of age, period and cohort. RESULTS: COPD mortality declined strongly over generations for people born from the early to mid 20th century, which was particularly evident for the first generation to grow up in a more economically developed environment for both sexes. Population wide COPD mortality decreased when air quality improved and increased with increasing air pollution. COPD mortality increased with age, particularly after menopause among women. CONCLUSIONS: Economic development may reduce vulnerability to COPD by reducing long-lasting insults to the respiratory system, such as infections, poor nutrition and indoor air pollution. However, some of these gains may be offset if economic development results in increasing air pollution or increasing smoking.

  8. Assessment of Nutritional Status and Developing Low Cost Recipes for Malnourished Children in the Tsunami affected Areas of Nagapattinam District

    Directory of Open Access Journals (Sweden)

    Raja lakshmi. J

    2011-04-01

    Full Text Available Background: The tsunami disaster in the Indian Ocean is one of the worst natural disasters in the modern times. The grief and worry created by the disaster has affected the health status of women and children. Malnutrition and ill health are major problems. This study investigated the nutritional status of the children and provided a nutrition education program for the mothers. Aims: To study the demographic profile, dietary habits, anthropometric measurements, clinical assessment, incident rates of infectious diseases among the 500 children. To assess the dietary intake of 100 malnourished children and to formulate ten low cost nutritionally balanced recipes and to provide nutrition education program for the mothers. Sample: 500 preschool children in the age group of 3-6 years of the tsunami affected Nagapattinam district were the samples of this study. Method: Interview schedule was administered to 500 mothers. Anthropometric measurements such as height, weight, mid arm circumference, head circumference and chest circumference were recorded by the investigator. Three day dietary recall method was used to assess the nutrient intake. Clinical assessment was conducted with the help of a doctor. Nutrition education was provided to the mothers with the help of posters and charts. Results: The results found that, majority of the children were under nourished and there was a significant difference between the mean nutrient intake and the recommended dietary allowance. Mean scores of nutritional knowledge and awareness significantly increased after the nutrition education program. Conclusion: Nutrition education must be provided to the mothers to improve the nutritional status of the children. The gained knowledge had to be put into practice.

  9. Factors that affected the development of a new albedo individual monitor at Instituto de Radioprotecao e Dosimetria - IRD

    International Nuclear Information System (INIS)

    IRD has worked in the development of an albedo individual monitor with two-components (albedo and incident). As desired characteristics, this monitor should have a lower detection limit smaller than 0.2 mSv for unmoderated 241 Am Be source and an optimum design project. For its development, several factors had to be analyzed in order to satisfy the requirements and characteristics desired. The monitor developed consists of the following parts: monitor support (badge), incident neutron shielding, moderator body and LiF:Mg,Ti thermoluminescent detectors (TLDs). This work presents a discussion on the factors evaluated, such as: albedo shape, moderator type, among others. (author)

  10. Overview of Development and Deployment of Codes, Standards and Regulations Affecting Energy Storage System Safety in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Conover, David R.

    2014-08-22

    This report acquaints stakeholders and interested parties involved in the development and/or deployment of energy storage systems (ESS) with the subject of safety-related codes, standards and regulations (CSRs). It is hoped that users of this document gain a more in depth and uniform understanding of safety-related CSR development and deployment that can foster improved communications among all ESS stakeholders and the collaboration needed to realize more timely acceptance and approval of safe ESS technology through appropriate CSR.

  11. Factors Affecting Market Entry Mode of Retailer to Enter Developing Country Markets: The Case of Tesco Supermarket

    OpenAIRE

    Rattanakomut, Rapeephan

    2013-01-01

    Intense market competition, market saturation and high rates of globalization have influenced businesses to seek foreign markets for factor endowment, increased sales and sustenance of long-term profits. Developing countries provide foreign markets with high potential owing to increasing incomes, high population and low production costs. This study attempts to apply the Dunning Eclectic Theory on the selection of modes of entry into foreign market in developing countries by Tesco Supermarket....

  12. The innate immune response affects the development of the autoimmune response in Theiler’s virus- induced demyelinating disease

    OpenAIRE

    Olson, Julie K.; Miller, Stephen D.

    2009-01-01

    Multiple sclerosis (MS) is a human CNS autoimmune demyelinating disease. Epidemiological evidence has suggested a role for virus infection in the initiation and/or exacerbation of MS. Theiler’s murine encephalomyelitis virus (TMEV)- induced demyelinating disease serves as a relevant mouse model for MS. TMEV- infected mice develop a demyelinating disease with clinical symptoms beginning around 35 days post infection which is associated with development of myelin- specific, PLP139–151, CD4+ T c...

  13. Empirical analyses of the factors affecting confirmation bias and the effects of confirmation bias on software developer/tester performance

    OpenAIRE

    Calikli, Gul; Bener, Ayse

    2010-01-01

    Background: During all levels of software testing, the goal should be to fail the code. However, software developers and testers are more likely to choose positive tests rather than negative ones due to the phenomenon called confirmation bias. Confirmation bias is defined as the tendency of people to verify their hypotheses rather than refuting them. In the literature, there are theories about the possible effects of confirmation bias on software development and testing. Due to the tendency t...

  14. Do Attitudes About Spoiling Children Affect Attitudes Regarding What Infants Need for Early Social-Emotional Development

    OpenAIRE

    Westover, Kathleen

    2012-01-01

    Secure infant attachment is important for the positive social-emotional development of children. Many parents have limited understanding of social-emotional development and the influence of appropriate responsive parenting behaviors to their infants’ cues. For example, many parents believe you can spoil an infant if you pick them up every time they cry. Researchers study the impact of positive responses to infants’ cues. Infants form a more secure attachment and learn to interpret the world a...

  15. Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients.

    Science.gov (United States)

    Nakayama, Takuya; Fisher, Marilyn; Nakajima, Keisuke; Odeleye, Akinleye O; Zimmerman, Keith B; Fish, Margaret B; Yaoita, Yoshio; Chojnowski, Jena L; Lauderdale, James D; Netland, Peter A; Grainger, Robert M

    2015-12-15

    Mutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal species, and the disease aniridia in humans. Despite extensive experimentation on this gene in multiple species, including humans, we still do not understand the earliest effects on development mediated by this gene. This prompted us to develop pax6 mutant lines in Xenopus tropicalis taking advantage of the utility of the Xenopus system for examining early development and in addition to establish a model for studying the human disease aniridia in an accessible lower vertebrate. We have generated mutants in pax6 by using Transcription Activator-Like Effector Nuclease (TALEN) constructs for gene editing in X. tropicalis. Embryos with putative null mutations show severe eye abnormalities and changes in brain development, as assessed by changes in morphology and gene expression. One gene that we found is downregulated very early in development in these pax6 mutants is myc, a gene involved in pluripotency and progenitor cell maintenance and likely a mediator of some key pax6 functions in the embryo. Changes in gene expression in the developing brain and pancreas reflect other important functions of pax6 during development. In mutations with partial loss of pax6 function eye development is initially relatively normal but froglets show an underdeveloped iris, similar to the classic phenotype (aniridia) seen in human patients with PAX6 mutations. Other eye abnormalities observed in these froglets, including cataracts and corneal defects, are also common in human aniridia. The frog model thus allows us to examine the earliest deficits in eye formation as a result of pax6 lesions, and provides a useful model for understanding the developmental basis for the aniridia phenotype seen in humans. PMID:25724657

  16. THE CONCEPT OF SUSTAINABLE DEVELOPMENT THROUGH ECONOMIC GROWTH AND DIVERSIFICATION OF THE LABOUR MARKET IN THE INDUSTRIAL AREAS AFFECTED BY RESTRUCTURING

    Directory of Open Access Journals (Sweden)

    Marius Eremia VLAICU POPA

    2013-06-01

    Full Text Available In the context of what is implemented through dualism "ecosystem-efficient", sustainable development involves the care of the human potential of the present situation and the future of its natural resources, energy, materials and information. As an effect of responsibility for future generations, the efficient use of resources requires, at the same time, the operation of a sustainable economy, by diversification and development of the labour market in order to meet present and future demands of human society. At local and regional level, through the closing of mines and large enterprises, with an effect in restructuring the economic sector and employment, development strategies and rehabilitation of the affected industrial areas as a common principle approach, analyzing the problems, defining the objectives and policies, identifying actions to attack problems and provide for mechanisms that will enable the progress control. In this paper it is presented the concept of sustainable development as imperative for economic growth, diversification and development of the labour market, being dealt the representative criteria and principles of sustainable development strategy of any company. Are defined the components and objectives of a strategy for local and regional development of industrial areas affected by the restructuring.

  17. Gaze Behavior and Affect at 6-Months: Predicting Clinical Outcomes and Language Development in Typically Developing Infants and Infants At-Risk for Autism

    OpenAIRE

    Young, Gregory S.; Merin, Noah; Rogers, Sally J.; Ozonoff, Sally

    2009-01-01

    This paper presents follow-up longitudinal data to research that previously suggested the possibility of abnormal gaze behavior marked by decreased eye contact in a subgroup of 6-month-old infants at risk for autism (Merin et al., 2007). Using eye-tracking data and behavioral data recorded during a live mother-infant interaction involving the still-face procedure, the predictive utility of gaze behavior and affective behaviors at 6 months was examined using diagnostic outcome data obtained lo...

  18. Effects of neonatal fluoxetine exposure on behavior across development in rats selectively bred for an infantile affective trait.

    Science.gov (United States)

    Zimmerberg, Betty; Germeyan, Sierra C

    2015-03-01

    Infants born to women with depressive symptoms are at higher risk for insecure attachment and behavioral problems. Thus current medical practice is to continue psychotropic medication of pregnant women with depression despite concerns about its behavioral teratology. There are few animal studies focused on long-term behavioral effects of prenatal antidepressant exposure; in addition, studies have not looked at individual differences in baseline affective state as a source of response variability. In this study, fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was administered to male and female rat pups from postnatal days 2-7 to model exposure to antidepressants in the human third trimester. Four behavioral measures were conducted from the neonatal to adult age periods in Low and High lines selectively bred for their rate of ultrasonic vocalizations after brief maternal separation. Neonatal fluoxetine administration decreased distress calls in both lines, but to a greater extent in High line rats than Low line. Neonatal fluoxetine also impaired motor coordination in neonates. Neonatal fluoxetine administration decreased social behavior in both juvenile and adult subjects. Fluoxetine-related reductions in anxiety behavior were not observed at the two older ages. As expected, High line subjects displayed more anxiety behavior than Low line subjects at all three test ages. These results suggest that there are may be significant behavioral consequences of antidepressant use during late pregnancy on offspring maternal attachment and social behavior, with implications for increased risk of autism spectrum disorders. PMID:25503615

  19. Territorial Management Within the Systems Affected by Mining.Case Study the South-Western Development Region in Romania

    Directory of Open Access Journals (Sweden)

    R. D. Pintilii

    2011-10-01

    Full Text Available The study is a concise form of some present days researches within the Interdisciplinary Centre for Advanced Researches on Territorial Dynamics within the University of Bucharest, which had as main major objective to identify and to underline the instability from the natural environment, determined by coal exploitation, as well as to identify the efficient management systems in some areas located in the south-western part of Romania, Oltenia. Researches identified the major effects these economic activities have upon air pollution, slopes’ dynamic, air and soil pollution. A special importance is given to the human component within territorial systems, as population is often dislodged to other localities and this phenomenon implies many social and economic consequences. One of the most important aggressions upon natural and built environment is that related to the landscape damage, following exploiting and processing rough material in order to obtain the final product, the coal. The direct impact of mining activities upon environment may be translated by a local biodiversity decrease, even if these coal mines are rehabilitated after they’re closed. Therefore, an integrated approach is necessary and it must refer to the way of administering mines for long term, by common actions of all the implied factors (government, mining companies and the local communities. The scientific demarche of building the model of environment management in the areas affected by mining took into account the new European context, which represents a supra system imposing the strategic coordinates where the process of managing territorial instability takes place.

  20. Placental Hypoxia Developed During Preeclampsia Induces Telocytes Apoptosis in Chorionic Villi Affecting The Maternal-Fetus Metabolic Exchange.

    Science.gov (United States)

    Bosco, Cleofina Becerra; Díaz, Eugenia Guerra; Gutierrez, Rodrigo Rojas; González, Jaime Montero; Parra-Cordero, Mauro; Rodrigo, Ramón Salinas; Barja, Pilar Yañez

    2016-01-01

    Telocytes (TC) are a new type of stromal cells initially found and studied in digestive and extra- digestive organs. These cells have a small cell body with 2 to 5 thin and extremely long cytoplasmic prolongations named telopodes. In recent years, TC have also been described in placental chorionic villi, located in a strategical position between the smooth muscle cells from fetal vessels and the myofibroblasts in the stromal villi. Unlike other organs, the placenta is not innervated and considering the strategic location of TC is has been postulated that TC function would be related to signal transduction mechanisms involved in the regulation of the fetal vessels blood flow, as well as in the shortening/lengthening of the chorionic villi, providing the necessary rhythmicity to the process of maternal/fetal metabolic exchange. Preeclampsia (PE) is a systemic syndrome that affects 4%-6% of pregnancies worldwide. It is characterized by a placental state of ischemia-hypoxia which triggers an oxidative stress stage with the concomitant production of reactive oxygen species (ROS) leading to an increase in the degree of placental apoptosis. Placental vascular tone is regulated by the vasodilator nitric oxide (NO) and, in PE cases, NO is diverted towards the formation of peroxynitrite, a powerful oxidative agent whose activity leads to an increase of placental apoptosis degree that compromises TC and myofibroblasts, a key feature we would like to emphasize in this work. PMID:25643124

  1. THE IMPACT OF THE EXPORTER FIRMS TO THE DEVELOPMENT AND THE FACTORS AFFECTING EXPORT PERFORMANCE OF THE FIRMS: AN APPLICATION ON THE SOUTHEASTERN ANATOLIA REGION

    Directory of Open Access Journals (Sweden)

    İbrahim ÇÜTÇÜ

    2013-06-01

    Full Text Available Regional development is the industrialization of the underdeveloped regions and thus creating a fair distribution of wealth inside the country, in order to eliminate the inequality resulting from the concentration of the industrialization in particular areas. The regional development policies, applied to achieve this main objective, vary according to the degree of inequality between regions. Foreign trade and especially the export sector are affecting many dynamics of the economy, and also act as important policy tools for achieving regional development. Literature review show that the developed regions are getting a greater share of the export, and therefore the export appears to be an important sector contributing to regional development. In this study, the relationship between regional development and export, and the factors that affect the export sector are examined in the case of the South-eastern Anatolia Region. A survey on 254 companies was conducted in order to find out the performance, potential and problems of the exporting companies in South-eastern Anatolia Region. Vast majority of the survey was conducted face to face, but a portion of it was done through the e-mails on Internet platform. The analysis of the data obtained from the survey is interpreted by using “SPSS 15.0 for Windows” statistical software using frequencies and averages.

  2. "Electric Power for Rural Growth: How Electricity Affects Rural Life in Developing Countries," by Douglas F. Barnes. [Book Review].

    Science.gov (United States)

    Lodwick, Dora G.; McIntosh, William A., Ed.

    1989-01-01

    Reviews a book assessing the effects of central grid rural electrification on the social and economic development of 192 communities in India and Colombia. The study examines the impact on agricultural productivity (through increased irrigation), the quality of life of women and children, business activities, and regional inequities. (SV)

  3. Recommendations for Implementing the New Illinois Early Learning and Development Standards to Affect Classroom Practices for Social and Emotional Learning

    Science.gov (United States)

    Zinsser, Katherine M.; Dusenbury, Linda

    2015-01-01

    The state of Illinois in the central United States has long been a trendsetter both in the development of learning standards and in addressing social and emotional learning in education settings. With a recent revision to the state's early learning standards, published in 2013, the Illinois State Board of Education (ISBE) fully aligned its…

  4. The Affective Side of Gifted Students' Development: Do We Need To Teach Students Intrapersonal and Interpersonal Skills?

    Science.gov (United States)

    Strop, Jean

    2000-01-01

    This brief article on emotional development of gifted students identifies key intrapersonal and interpersonal skills including self-awareness; the ability to regulate thoughts, emotions, and behaviors; self-acceptance; the ability to desire and demonstrate basic social skills; the ability to respond to the needs of others; and the ability to…

  5. Dietary-induced chronic hypothyroidism negatively affects rat follicular development and ovulation rate and is associated with oxidative stress

    NARCIS (Netherlands)

    Meng, Li; Rijntjes, E.; Swarts, Hans; Bunschoten, Annelies; Romijnders-van der Stelt, Inge; Keijer, Jaap; Teerds, Katja

    2016-01-01

    The long-term effects of chronic hypothyroidism on ovarian follicular development in adulthood are not well known. Using a rat model of chronic diet-induced hypothyroidism initiated in the fetal period, we investigated the effects of prolonged reduced plasma thyroid hormone concentrations on the

  6. Altered Phenylpropanoid Metabolism in the Maize Lc-Expressed Sweet Potato (Ipomoea batatas) Affects Storage Root Development.

    Science.gov (United States)

    Wang, Hongxia; Yang, Jun; Zhang, Min; Fan, Weijuan; Firon, Nurit; Pattanaik, Sitakanta; Yuan, Ling; Zhang, Peng

    2016-01-01

    There is no direct evidence of the effect of lignin metabolism on early storage root development in sweet potato. In this study, we found that heterologous expression of the maize leaf color (Lc) gene in sweet potato increased anthocyanin pigment accumulation in the whole plant and resulted in reduced size with an increased length/width ratio, low yield and less starch content in the early storage roots. RT-PCR analysis revealed dramatic up-regulation of the genes involved in the lignin biosynthesis pathway in developing storage roots, leading to greater lignin content in the Lc transgenic lines, compared to the wild type. This was also evidenced by the enhanced lignification of vascular cells in the early storage roots. Furthermore, increased expression of the β-amylase gene in leaves and storage roots also accelerated starch degradation and increased the sugar use efficiency, providing more energy and carbohydrate sources for lignin biosynthesis in the Lc transgenic sweet potato. Lesser starch accumulation was observed in the developing storage roots at the initiation stage in the Lc plants. Our study provides experimental evidence of the basic carbohydrate metabolism underlying the development of storage roots, which is the transformation of lignin biosynthesis to starch biosynthesis. PMID:26727353

  7. Research Review: Maternal Prenatal Distress and Poor Nutrition--Mutually Influencing Risk Factors Affecting Infant Neurocognitive Development

    Science.gov (United States)

    Monk, Catherine; Georgieff, Michael K.; Osterholm, Erin A.

    2013-01-01

    Background: Accumulating data from animal and human studies indicate that the prenatal environment plays a significant role in shaping children's neurocognitive development. Clinical, epidemiologic, and basic science research suggests that two experiences relatively common in pregnancy--an unhealthy maternal diet and psychosocial…

  8. The development of a rich multimedia training environment for crisis management: using emotional affect to enhance learning

    OpenAIRE

    Bacon, Liz; Windall, Gillian; MacKinnon, Lachlan

    2011-01-01

    PANDORA is an EU FP7-funded project developing a novel training and learning environment for Gold Commanders, individuals who carry executive responsibility for the services and facilities identified as strategically critical e.g. Police, Fire, in crisis management strategic planning situations. A key part of the work for this project is considering the emotional and behavioural state of the trainees, and the creation of more realistic, and thereby stressful, representations of multimedia inf...

  9. The development of a rich multimedia training environment for crisis management: using emotional affect to enhance learning

    OpenAIRE

    Bacon, Liz; Windall, Gill; MacKinnon, Lachlan

    2012-01-01

    PANDORA is an EU FP7-funded project developing a novel training and learning environment for Gold Commanders, individualswho carry executive responsibility for the services and facilities identified as strategically critical e.g. Police, Fire, in crisis management strategic planning situations. A key part of the work for this project is considering the emotional and behavioural state of the trainees, and the creation of more realistic, and thereby stressful, representations of multimedia info...

  10. Factors Affecting the Development of Land Rental Markets in China A Case Study for Puding County, Guizhou Province

    OpenAIRE

    Tu, Qin; Heerink, Nico; Xing, Li

    2006-01-01

    The development of land rental markets can enhance agricultural productivity and equity by facilitating transfers of land to more productive farmers and facilitating the participation in the non-farm economy of less productive farmers. In recent years there has been a rapid increase in the incidence of land rental activities in China. Large differences exist, however, both between regions and within regions in the share of households participating in land renting activities. The purpose of th...

  11. Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

    Directory of Open Access Journals (Sweden)

    Ariane Willems

    Full Text Available The observation that mice with a selective ablation of the androgen receptor (AR in Sertoli cells (SC (SCARKO mice display a complete block in meiosis supports the contention that SC play a pivotal role in the control of germ cell development by androgens. To delineate the physiological and molecular mechanism responsible for this control, we compared tubular development in pubertal SCARKO mice and littermate controls. Particular attention was paid to differences in SC maturation, SC barrier formation and cytoskeletal organization and to the molecular mediators potentially involved. Functional analysis of SC barrier development by hypertonic perfusion and lanthanum permeation techniques and immunohistochemical analysis of junction formation showed that SCARKO mice still attempt to produce a barrier separating basal and adluminal compartment but that barrier formation is delayed and defective. Defective barrier formation was accompanied by disturbances in SC nuclear maturation (immature shape, absence of prominent, tripartite nucleoli and SC polarization (aberrant positioning of SC nuclei and cytoskeletal elements such as vimentin. Quantitative RT-PCR was used to study the transcript levels of genes potentially related to the described phenomena between day 8 and 35. Differences in the expression of SC genes known to play a role in junction formation could be shown from day 8 for Cldn11, from day 15 for Cldn3 and Espn, from day 20 for Cdh2 and Jam3 and from day 35 for ZO-1. Marked differences were also noted in the transcript levels of several genes that are also related to cell adhesion and cytoskeletal dynamics but that have not yet been studied in SC (Actn3, Ank3, Anxa9, Scin, Emb, Mpzl2. It is concluded that absence of a functional AR in SC impedes the remodeling of testicular tubules expected at the onset of spermatogenesis and interferes with the creation of the specific environment needed for germ cell development.

  12. Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures

    OpenAIRE

    Warringa, R.A.J.; Hoeben, R C; Koper, W.J.; Sykes, J.E.C.; Golde, L.M.G. van; Lopes-Cardozo, M.

    1987-01-01

    Cultures of glial cells were prepared from the brains of one-week-old rat pups. After one day in culture, serum was omitted from the medium and replaced by a combination of growth-stimulating hormones and other factors that enhanced the percentage of oligodendrocytes in the cultures. We investigated the effects of hydrocortisone on the development of oligodendrocytes, on the activities of oligodendrocyte-specific enzymes and on glucose- and lipid-metabolism of the glial cells. (1) Hydrocortis...

  13. A review on granules initiation and development inside UASB Reactor and the main factors affecting granules formation process

    OpenAIRE

    S. A. Habeeb, AB. Aziz Bin Abdul Latiff, Zawawi Bin Daud, Zulkifli Bin Ahmad

    2011-01-01

    Decades of investigations and explorations in the field of anaerobic wastewater treatment have resulted in significant indications about the role importance of sludge granules in biodegradation anaerobic process. It is believed that the development of anaerobic granules is reflecting an important role on the performance of reactor. An overview on the concept of up-flow anaerobic sludge bed UASB reactor operation as well as the main parts that reactor consists of is briefly explained in this p...

  14. Is the"Japan Problem"real? How problems in Japan's financial sector could affect developing regions

    OpenAIRE

    Shigeru Otsubo; Masahiko Tsutsumi

    1996-01-01

    The burst of the Japanese financial bubble in the early 1990s has increased the bad debts of Japan's financial institutions. Japan accounts for about 20 percent of foreign aid to developing countries and for 10 percent of their exports, so Japan's economic health is important. The authors analyze the situation, assess the bad debt stock, and simulate the likely effects of crises in Japan's financial sector. They conclude that: a) a crisis that would shake up the world financial market is unli...

  15. Leaf anatomy during leaf development of photoautotrophically in vitro -grown tobacco plants as affected by growth irradiance

    Czech Academy of Sciences Publication Activity Database

    Radochová, Barbora; Tichá, I.

    2009-01-01

    Roč. 53, č. 1 (2009), s. 21-27. ISSN 0006-3134 Grant ostatní: Univerzita Karlova(CZ) 100/1998; Univerzita Karlova(CZ) 96/1998; EC(XE) ERBCIPACT930115; Volkswagen-Stiftung(DE) I/68918 Institutional research plan: CEZ:AV0Z50110509 Keywords : in vitro * leaf development * chloroplast Subject RIV: EA - Cell Biology Impact factor: 1.656, year: 2009

  16. The Factors Affecting the Development of National Identity as South Korean in North Korean Refugees Living in South Korea

    OpenAIRE

    Yu, Shi-Eun; Eom, Jin-Sup; Jeon, Woo-Taek

    2012-01-01

    Objective This study aims to observe the factors that influence the development of national identity of North Korean refugees who have resettled in South Korea. Methods The study population was comprised of 500 North Korean refugees who immigrated to South Korea in 2007. The variables measured national identity as South Korean, a scale for discrimination perceived during daily life, a social for supporting social network, a for childhood trauma experience, traumatic experiences in North Korea...

  17. In ovo L-arginine supplementation stimulates myoblast differentiation but negatively affects muscle development of broiler chicken after hatching.

    Science.gov (United States)

    Li, Y; Wang, Y; Willems, E; Willemsen, H; Franssens, L; Buyse, J; Decuypere, E; Everaert, N

    2016-02-01

    In this study, we tested the hypothesis that in ovo feeding (IOF) of L-arginine (L-Arg) enhances nitric oxide (NO) production, stimulates the process of myogenesis, and regulates post-hatching muscle growth. Different doses of L-Arg were injected into the amnion of chicken embryos at embryonic day (ED) 16. After hatching, the body weight of individual male chickens was recorded weekly for 3 weeks. During in vitro experiments, myoblasts of the pectoralis major (PM) were extracted at ED16 and were incubated in medium containing 0.01 mm L-Arg, 0.05 mm L-Arg, and (or) 0.05 mm L-nitro-arginine-methyl-ester (L-NAME), an inhibitor of nitric oxide synthase (NOS). When 25 mg/kg L-Arg/initial egg weight was injected, no difference was observed in body weight at hatch, but a significant decrease was found during the following 3 weeks compared to that of the non-injected and saline-injected control, and this also affected the growth of muscle mass. L-NAME inhibited gene expression of myogenic differentiation antigen (MyoD), myogenin, NOS, and follistatin, decreased the cell viability, and increased myostatin (MSTN) gene expression. 0.05 mm L-Arg stimulated myogenin gene expression but also depressed muscle cell viability. L-NAME blocked the effect of 0.05 mm L-Arg on myogenin mRNA levels when co-incubated with 0.05 mm L-Arg. L-Arg treatments had no significant influence on NOS mRNA gene expression, but had inhibiting effect on follistatin gene expression, while L-NAME treatments had effects on both. These results suggested that L-Arg stimulated myoblast differentiation, but the limited number of myoblasts would form less myotubes and then less myofibers, while the latter limited the growth of muscle mass. PMID:25846259

  18. Root exudation and root development of lettuce (Lactuca sativa L.cv. Tizian as affected by different soils

    Directory of Open Access Journals (Sweden)

    GünterNeumann

    2014-01-01

    Full Text Available Development and activity of plant roots exhibits high adaptive variability. Although it is well-documented, that physicochemical soil properties can strongly influence root morphology and root exudation, particularly under field conditions, a comparative assessment is complicated by the impact of additional factors, such as climate and cropping history. To overcome these limitations, in this study, field soils originating from an unique experimental plot system with three different soil types, which were stored at the same field site for ten years and exposed to the same agricultural management practice, were used for an investigation on effects of soil type on root development and root exudation. Lettuce (Lactuca sativa L. cv. Tizian was used as a model plant, grown under controlled environmental conditions in a minirhizotrone system equipped with root observation windows (rhizoboxes. Root exudates were collected by placing sorption filters onto the root surface followed by subsequent extraction and GC-MS profiling of the trapped compounds. Surprisingly, even in absence of external stress factors with known impact on root exudation, such as pH extremes, water and nutrient limitations/toxicities or soil structure effects (use of sieved soils, root growth characteristics (root length, fine root development as well as profiles of root exudates were strongly influenced by the soil type used for plant cultivation. The results coincided well with differences in rhizosphere bacterial communities, detected in field-grown lettuce plants cultivated on the same soils (Schreiter et al., this issue. The findings suggest that the observed differences may be the result of plant interactions with the soil-specific microbiomes.

  19. Altered Phenylpropanoid Metabolism in the Maize Lc-Expressed Sweet Potato (Ipomoea batatas) Affects Storage Root Development

    OpenAIRE

    Hongxia Wang; Jun Yang; Min Zhang; Weijuan Fan; Nurit Firon; Sitakanta Pattanaik; Ling Yuan; Peng Zhang

    2016-01-01

    There is no direct evidence of the effect of lignin metabolism on early storage root development in sweet potato. In this study, we found that heterologous expression of the maize leaf color (Lc) gene in sweet potato increased anthocyanin pigment accumulation in the whole plant and resulted in reduced size with an increased length/width ratio, low yield and less starch content in the early storage roots. RT-PCR analysis revealed dramatic up-regulation of the genes involved in the lignin biosy...

  20. NOS2 Is Critical to the Development of Emphysema in Sftpd Deficient Mice but Does Not Affect Surfactant Homeostasis

    OpenAIRE

    Knudsen, Lars; Atochina-Vasserman, Elena N.; GUO, CHANG-JIANG; Pamela A Scott; Haenni, Beat; Beers, Michael F.; Ochs, Matthias; Gow, Andrew J.

    2014-01-01

    Rationale Surfactant protein D (SP-D) has important immuno-modulatory properties. The absence of SP-D results in an inducible NO synthase (iNOS, coded by NOS2 gene) related chronic inflammation, development of emphysema-like pathophysiology and alterations of surfactant homeostasis. Objective In order to test the hypothesis that SP-D deficiency related abnormalities in pulmonary structure and function are a consequence of iNOS induced inflammation, we generated SP-D and iNOS double knockout m...

  1. Post-irradiation dietary vitamin E does not affect the development of radiation-induced lung damage in rats

    International Nuclear Information System (INIS)

    The purpose of this study was to investigate whether application of post-irradiation vitamin E, an anti-oxidant, could prevent the development of radiation induced lung damage. Wistar rats were given vitamin E enriched or vitamin E deprived food starting from 4 weeks after 18 Gy single dose irradiation of the right thorax. Neither breathing frequencies nor CT density measurements revealed differences between the groups. It is concluded that post-irradiation vitamin E does not influence radiation-induced fibrosis to the lung

  2. Analysing the factors affecting gully development and their relationships with land-use changes in the east Alentejo (Portugal)

    International Nuclear Information System (INIS)

    The land abandonment and land-use changes as a consequence of the implementation of the European Union common Agricultural Policy (C. A. P.) in the SE of Portugal, have been generating, differences in the equilibrium of the geomorphic processes. The head waters catchments of some of the Guadiana River tributaries show in the study area several degrees of gully initiation and development both on the hillsides and valley bottom in fill. this gully generation process is closely related with the changes in the soil and cover properties occurring when agricultural practises have been replaced by intensive grazing areas or by abandoned land. (Author) 7 refs.

  3. Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.

    Science.gov (United States)

    Ventrella, Emanuela; Adamski, Zbigniew; Chudzińska, Ewa; Miądowicz-Kobielska, Mariola; Marciniak, Paweł; Büyükgüzel, Ender; Büyükgüzel, Kemal; Erdem, Meltem; Falabella, Patrizia; Scrano, Laura; Bufo, Sabino Aurelio

    2016-01-01

    Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids α-solanine, α-chaconine and α-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed) generation, addition of each extract reduced the number of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture. PMID:27213896

  4. Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Emanuela Ventrella

    Full Text Available Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids α-solanine, α-chaconine and α-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed generation, addition of each extract reduced the number of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture.

  5. Soyabean fortification and enrichment of regular and quality protein maize tortillas affects brain development and maze performance of rats.

    Science.gov (United States)

    Amaya-Guerra, Carlos; Serna Saldívar, Sergio O; Alanis-Guzman, Maria Guadalupe

    2006-07-01

    The brain development and performance of rats fed throughout two generations with an indigenous maize tortilla-based diet was studied. The experiment compared casein control with five different diets produced from: regular fresh masa; regular, enriched dry masa flour containing thiamin, riboflavin, niacin, folic acid, Fe and Zn (REDMF); dry masa flour fortified with 60 g/kg defatted soyabean meal and enriched (FEDMF); enriched quality protein maize (QPM) flour (EQPM); QPM flour fortified with 30 g/kg defatted soyabean meal and enriched (FEQPM). In both generations, brain and cerebellum weights and myelin concentration were significantly higher (P 0.05) in brain DNA in first-generation rats; however, second-generation rats fed FEDMF, EQPM and FEQPM tortillas had higher cerebral DNA, neuron size and brain activity as estimated by the RNA:DNA ratio. Short-term and long-term memory performance in the Morris maze improved (P tortillas enriched with selected micronutrients and fortified with soyabean is highly recommended to assure adequate brain development. The high lysine-tryptophan QPM made it possible to save half of the soyabean flour without sacrificing the nutritional value of soyabean-fortified tortillas. PMID:16870005

  6. Transient in utero knockout (TIUKO of C-MYC affects late lung and intestinal development in the mouse

    Directory of Open Access Journals (Sweden)

    Zhou Pengbo

    2004-04-01

    Full Text Available Abstract Background Developmentally important genes often result in early lethality in knockout animals. Thus, the direct role of genes in late gestation organogenesis cannot be assessed directly. In utero delivery of transgenes was shown previously to result in high efficiency transfer to pulmonary and intestinal epithelial stem cells. Thus, this technology can be used to evaluate late gestation development. Results In utero gene transfer was used to transfer adenovirus with either an antisense c-myc or a C-MYC ubiquitin targeting protein to knockout out c-myc expression in late gestation lung and intestines. Using either antisense or ubiquitin mediated knockout of C-MYC levels in late gestation resulted in similar effects. Decreased complexity was observed in both intestines and lungs. Stunted growth of villi was evident in the intestines. In the lung, hypoplastic lungs with disrupted aveolarization were observed. Conclusions These data demonstrated that C-MYC was required for cell expansion and complexity in late gestation lung and intestinal development. In addition they demonstrate that transient in utero knockout of proteins may be used to determine the role of developmentally important genes in the lungs and intestines.

  7. A review on granules initiation and development inside UASB Reactor and the main factors affecting granules formation process

    Directory of Open Access Journals (Sweden)

    S. A. Habeeb, AB. Aziz Bin Abdul Latiff, Zawawi Bin Daud, Zulkifli Bin Ahmad

    2011-03-01

    Full Text Available Decades of investigations and explorations in the field of anaerobic wastewater treatment have resulted in significant indications about the role importance of sludge granules in biodegradation anaerobic process. It is believed that the development of anaerobic granules is reflecting an important role on the performance of reactor. An overview on the concept of up-flow anaerobic sludge bed UASB reactor operation as well as the main parts that reactor consists of is briefly explained in this paper, whereas the major theories of anaerobic granules formation are listed by related researchers. The correlations and compositions of such sludge granule have been specifically explained. It is believed that the extracellular polymer (ECP is totally responsible of bacterial cell correlations and the formation of bacterial communities in the form of granules. In addition, the dependable factors for the performance of anaerobic granules formation process e.g. temperature, organic loading rate, pH, and alkalinity, nutrients, and cations and heavy metals have been discussed in this paper. Strong evidences proved that the process of gas production in the form of biogas is related to the methanogens activities, which are practically found in the core of granules. The aim of this review is to explore and assess the mechanisms of granules initiation and development inside UASB reactor.

  8. Studies on improving ostrich egg hatch ability and its relation with some factors affecting embryonic development during artificial incubation

    International Nuclear Information System (INIS)

    The present study was carried out in co-operation between the Ostrich Production Farm, Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt and the Faculty of Agriculture, AL-Azhar University, Nasr City, Cairo, Egypt. Ostrich eggs were obtained from Resk Company for Ostrich Production and set for incubation at ElShfie Farm, Belbas, Sharkia, Egypt. The objectives are:1- To follow up changes in some vital physiological parameters and blood components associated with ostrich embryonic development during incubation and to provide reference blood biochemical baseline values for future studies of avian species and to document novel information on some normal changes associated with growth of the developing ostrich embryo during the incubation, as no similar and complete data could be found on this aspect in the literature. 2- In an effort to improve the hatch ability and hatching performance of ostrich eggs by testing the effect of in ovo injection of several nutrients. Two trials were carried out: 1-First trial To follow up changes in some vital physiological parameters and blood components associated with ostrich embryonic development during incubation. A total number of 60 ostrich eggs weighed between 1300 and 1500 g were obtained from from Resk Company for Ostrich Production. Eggs were collected weekly in patches of 25 eggs and Egg incubation was performed in ElShfie Farm, Belbas, Egypt. Egg weight and egg weight loss during incubation were determined on each eggs.2- Second Trial In vivo injection In an effort to improve the hatch ability and hatching performance of ostrich eggs by testing the effect of in ovo injection of several nutrients. A total of 100 fertile ostrich eggs weighed between 1300 and 1500 g were obtained from from Resk Company for Ostrich Production. Eggs were collected weekly in patches of 25 eggs and egg incubation was performed in ElShfie Farm, Belbas, Egypt. Eggs were injected at the 7th day of incubation to deposit test material in

  9. Nitric oxide affects ERK signaling through down-regulation of MAP kinase phosphatase levels during larval development of the ascidian Ciona intestinalis.

    Directory of Open Access Journals (Sweden)

    Immacolata Castellano

    Full Text Available In the ascidian Ciona intestinalis larval development and metamorphosis require a complex interplay of events, including nitric oxide (NO production, MAP kinases (ERK, JNK and caspase-3 activation. We have previously shown that NO levels affect the rate of metamorphosis, regulate caspase activity and promote an oxidative stress pathway, resulting in protein nitration. Here, we report that NO down-regulates MAP kinase phosphatases (mkps expression affecting positively ERK signaling. By pharmacological approach, we observed that the reduction of endogenous NO levels caused a decrease of ERK phosphorylation, whereas increasing levels of NO induced ERK activation. We have also identified the ERK gene network affected by NO, including mpk1, mpk3 and some key developmental genes by quantitative gene expression analysis. We demonstrate that NO induces an ERK-independent down-regulation of mkp1 and mkp3, responsible for maintaining the ERK phosphorylation levels necessary for transcription of key metamorphic genes, such as the hormone receptor rev-erb and the van willebrand protein vwa1c. These results add new insights into the role played by NO during larval development and metamorphosis in Ciona, highlighting the cross-talk between different signaling pathways.

  10. The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice

    Institute of Scientific and Technical Information of China (English)

    Deyong Ren; Li Zhu; Zhenyu Gao; Guojun Dong; Guangheng Zhang; Longbiao Guo; Dali Zeng; and Qian Qian; Yuchun Rao; Liwen Wu; Qiankun Xu; Zizhuang Li; Haiping Yu; Yu Zhang; Yujia Leng; Jiang Hu

    2016-01-01

    Moderate plant height and successful establish-ment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study, we characterized a rice gene, ABNORMAL FLOWER AND DWARF1 (AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules. AFD1 encoded a DUF640 domain protein and was ex-pressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein (GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes.

  11. The main directions of the social and economic development of agricultural areas affected by the Chernobyl accident

    International Nuclear Information System (INIS)

    Is spoken about change of state strategic installation on management of agricultural territory: refusal from practically inefficient tactical both operative and transition to the organization system business - planning all agricultural subjects also legal, investment, consulting, control and insurance support realization the developed plans. On the basis of the common circuit of social and economic rehabilitation, ordering of the agricultural enterprises and classifications of areas are offered three scripts of rehabilitation. The area of the first group assumes creation of several agrarian financial and industrial groups with meat, dairy and agricultural specialization. The area of the second group is a zone of the most risky agriculture and the big remoteness of facilities from each other and from the regional center. The area of thirds of group includes the majority of injured areas of the Gomel and Magilew regions

  12. Effect of welding conditions on transformation and properties of heat-affected zones in LWR [light-water reactor] vessel steels

    International Nuclear Information System (INIS)

    The continuous cooling transformation behavior (CCT) and isothermal transformation (IT) behavior were determined for SA-508 and SA-533 materials for conditions pertaining to standard heat treatment and for the coarse-grained region of the heat-affected zone (HAZ). The resulting diagrams help to select welding conditions that produce the most favorable microconstituent for the development of optimum postweld heat treatment (PWHT) toughness levels. In the case of SA-508 and SA-533, martensite responds more favorably to PWHT than does bainite. Bainite is to be avoided for the optimum toughness characteristics of the HAZ. The reheat cracking tendency for both steels was evaluated by metallographic studies of simulated HAZ structures subjected to PWHT cycles and simultaneous restraint. Both SA-533, Grade B, Class 1, and SA-508, Class 2, cracked intergranularly. The stress rupture parameter (the product of the stress for a rupture life of 10 min and the corresponding reduction of area) calculated for both steels showed that SA-508, Class 2, was more susceptible to reheat cracking than SA-533, Grade B, Class 1. Cold cracking tests (Battelle Test and University of Tennessee modified hydrogen susceptibility test) indicated that a higher preheat temperature is required for SA-508, Class 2, to avoid cracking than is required for SA-533, Grade B, Class 1. Further, the Hydrogen Susceptibility Test showed that SA-508, Class 2, is more susceptible to hydrogen embrittlement than is SA-533, Grade B, Class 1

  13. Transgenic Cotton-Fed Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) Affects the Parasitoid Encarsia desantisi Viggiani (Hymenoptera: Aphelinidae) Development.

    Science.gov (United States)

    Pessoa, R; Rossi, G D; Busoli, A C

    2016-02-01

    Cotton cultivars expressing Cry proteins are widely used to control lepidopteran pests. The effects of transgenic plants containing insecticidal Cry proteins on non-target species must be comprehended for a better and rational use of this technology for pest management. We investigated the influence of the Bt cotton cultivars NuOPAL and FM 975 on biological parameters of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), a non-target pest of Bt cotton cultivars and on its parasitoid Encarsia desantisi Viggiani (Hymenoptera: Aphelinidae). The experiments were conducted in a climatized room, and the non-transgenic near isolines were used for rearing whiteflies as control hosts. The effects of the Bt cotton cultivars on the period of embryonic and larval development and the percentage of adult emergence of B. tabaci were assessed. The period required for embryonic, larval, and pupal development and the percentage of emergence and longevity of E. desantisi females were determined using Bt cotton-fed and non-Bt cotton-fed B. tabaci as hosts. Both Bt cotton cultivars resulted in a decrease of approximately 20% of adult emergence of B. tabaci. Differently, an increase of approximately 10% of adult emergence of E. desantisi was observed for parasitoids that used hosts fed with both Bt cotton cultivars. However, female parasitoid longevity decreased when their hosts were fed on Bt cotton cultivars. Our data suggest that the use of Bt cotton cultivars in association with the biological control agent E. desantisi could be functional for the management of B. tabaci in Bt cotton crops. PMID:26431703

  14. Pain, Affect, and Attachment

    OpenAIRE

    Carl Eduard Scheidt; Elisabeth Waller

    2015-01-01

    Various psychodynamic processes may underlie the development of psychogenic pain disorder such as conversion, the displacement of affect, or narcissistic defenses. However, many of the processes suggested are related to a disorder of affect regulation. The term affect regulation in psychoanalytic literature refers to phenomena which are often described by the concept of alexithymia. Empirical observations suggest that alexithymia is correlated to insecure attachment, especially an insecure di...

  15. The development of a rich multimedia training environment for crisis management: using emotional affect to enhance learning

    Directory of Open Access Journals (Sweden)

    Liz Bacon

    2011-02-01

    Full Text Available PANDORA is an EU FP7-funded project developing a novel training and learning environment for Gold Commanders, individualswho carry executive responsibility for the services and facilities identified as strategically critical e.g. Police, Fire, in crisis management strategic planning situations. A key part of the work for this project is considering the emotional and behavioural state of the trainees, and the creation of more realistic, and thereby stressful, representations of multimedia information to impact on the decision-making of those trainees. Existing training models are predominantly paper-based, table-top exercises, which require an exercise of imagination on the part of the trainees to consider not only the various aspects of a crisis situation but also the impacts of interventions, and remediating actions in the event of the failure of an intervention. However, existing computing models and tools are focused on supporting tactical and operational activities in crisis management, not strategic. Therefore, the PANDORA system will provide a rich multimedia information environment, to provide trainees with the detailed information they require to develop strategic plans to deal with a crisis scenario, and will then provide information on the impacts of the implementation of those plans and provide the opportunity for the trainees to revise and remediate those plans. Since this activity is invariably multi-agency, the training environment must support group-based strategic planning activities and trainees will occupy specific roles within the crisis scenario. The system will also provide a range of non-playing characters (NPC representing domain experts, high-level controllers (e.g. politicians, ministers, low-level controllers (tactical and operational commanders, and missing trainee roles, to ensure a fully populated scenario can be realised in each instantiation. Within the environment, the emotional and behavioural state of the

  16. AtSWEET4, a hexose facilitator, mediates sugar transport to axial sinks and affects plant development.

    Science.gov (United States)

    Liu, Xiaozhu; Zhang, Yan; Yang, Chao; Tian, Zhihong; Li, Jianxiong

    2016-01-01

    Plants transport photoassimilates from source organs to sink tissues through the phloem translocation pathway. In the transport phloem, sugars that escape from the sieve tubes are released into the apoplasmic space between the sieve element/companion cell complex (SE/CC) and phloem parenchyma cells (PPCs) during the process of long-distance transport. The competition for sugar acquisition between SE/CC and adjoining PPCs is mediated by plasma membrane translocators. YFP-tagged AtSWEET4 protein is localized in the plasma membrane, and PromoterAtSWEET4-GUS analysis showed that AtSWEET4 is expressed in the stele of roots and veins of leaves and flowers. Overexpression of AtSWEET4 in Arabidopsis increases plant size and accumulates more glucose and fructose. By contrast, knock-down of AtSWEET4 by RNA-interference leads to small plant size, reduction in glucose and fructose contents, chlorosis in the leaf vein network, and reduction in chlorophyll content in leaves. Yeast assays demonstrated that AtSWEET4 is able to complement both fructose and glucose transport deficiency. Transgenic plants of AtSWEET4 overexpression exhibit higher freezing tolerance and support more growth of bacterium Pseudomonas syringae pv. phaseolicola NPS3121. We conclude that AtSWEET4 plays an important role in mediating sugar transport in axial tissues during plant growth and development. PMID:27102826

  17. Application of wind tunnel tests to the development of solutions to problems related to immissions which affect urban climates

    International Nuclear Information System (INIS)

    In the last two decades urban climatology has developed to a pragmatically oriented field of research. Synthetic-functional maps of the climate and derived maps for town planning have widely been accepted by municipal or communal management. However, there is a disadvantage of the generalized urban-climatic maps because they only show the actual climatic state for stable sunny weather conditions. When future planning is done with due regard to forecasts on possible changes of the climatic or air-hygienic conditions, it is necessary to carry out model calculations and/or wind tunnel experiments. Because of the complexity of urban building structures, it is still difficult to acquire necessary information by numeric models. In most cases wind tunnel measurements will have to be carried out. After having illustrated the methods of wind tunnel experiments, the following paper shows results from measurements carried out for a street canyon with dense traffic in Duesseldorf's northern quarter Moersenbroich. This investigation intended to show how the field of immissions - mainly caused by traffic - changes after the construction of a six-storey office building on a remaining free space. It proved that the planned building wouldn't really lead to a deterioration of the field of the immissive situation. On the contrary, in most cases we could measure a reduced amount of pollution compared to the former building structure with a free spot. Only in few cases, the new building led to increased values in proportion to the given threshold values. (orig.)

  18. Factors affecting the development of adverse drug reactions to β-blockers in hospitalized cardiac patient population

    Science.gov (United States)

    Mugoša, Snežana; Djordjević, Nataša; Djukanović, Nina; Protić, Dragana; Bukumirić, Zoran; Radosavljević, Ivan; Bošković, Aneta; Todorović, Zoran

    2016-01-01

    The aim of the present study was to undertake a study on the prevalence of cytochrome P450 2D6 (CYP2D6) poor metabolizer alleles (*3, *4, *5, and *6) on a Montenegrin population and its impact on developing adverse drug reactions (ADRs) of β-blockers in a hospitalized cardiac patient population. A prospective study was conducted in the Cardiology Center of the Clinical Center of Montenegro and included 138 patients who had received any β-blocker in their therapy. ADRs were collected using a specially designed questionnaire, based on the symptom list and any signs that could point to eventual ADRs. Data from patients’ medical charts, laboratory tests, and other available parameters were observed and combined with the data from the questionnaire. ADRs to β-blockers were observed in 15 (10.9%) patients. There was a statistically significant difference in the frequency of ADRs in relation to genetically determined enzymatic activity (Phospitalization, CYP2D6 poor metabolizer phenotype, and the concomitant use of other CYP2D6-metabolizing drugs. Therefore, in hospitalized patients with polypharmacy CYP2D6 genotyping might be useful in detecting those at risk of ADRs.

  19. MiR-449a Affects Epithelial Proliferation during the Pseudoglandular and Canalicular Phases of Avian and Mammal Lung Development

    Science.gov (United States)

    Sanford, Ethan L.; Choy, Kwong W.; Donahoe, Patricia K.; Tracy, Adam A.; Hila, Regis

    2016-01-01

    Congenital diaphragmatic hernia is associated with pulmonary hypoplasia and respiratory distress, which result in high mortality and morbidity. Although several transgenic mouse models of lung hypoplasia exist, the role of miRNAs in this phenotype is incompletely characterized. In this study, we assessed microRNA expression levels during the pseudoglandular to canalicular phase transition of normal human fetal lung development. At this critical time, when the distal respiratory portion of the airways begins to form, microarray analysis showed that the most significantly differentially expressed miRNA was miR-449a. Prediction algorithms determined that N-myc is a target of miR-449a and identified the likely miR-449a:N-myc binding sites, confirmed by luciferase assays and targeted mutagenesis. Functional ex vivo knock-down in organ cultures of murine embryonic lungs, as well as in ovo overexpression in avian embryonic lungs, suggested a role for miR-449a in distal epithelial proliferation. Finally, miR-449a expression was found to be abnormal in rare pulmonary specimens of human fetuses with Congenital Diaphragmatic Hernia in the pseudoglandular or canalicular phase. This study confirms the conserved role of miR-449a for proper pulmonary organogenesis, supporting the delicate balance between expansion of progenitor cells and their terminal differentiation, and proposes the potential involvement of this miRNA in human pulmonary hypoplasia. PMID:26891231

  20. Gene dosage of the transcription factor Fingerin (bHLHA9) affects digit development and links syndactyly to ectrodactyly.

    Science.gov (United States)

    Schatz, Omri; Langer, Erez; Ben-Arie, Nissim

    2014-10-15

    Distal limb deformities are congenital malformations with phenotypic variability, genetic heterogeneity and complex inheritance. Among these, split-hand/foot malformation is an ectrodactyly with missing central fingers, yielding a lobster claw-like hand, which when combined with long-bone deficiency is defined as split-hand/foot malformation and long-bone deficiency (SHFLD) that is genetically heterogeneous. Copy number variation (CNV) consisting of 17p13.3 duplication was identified in unrelated pedigrees, underlying SHFLD3 (OMIM 612576). Although the transcription factor Fingerin (bHLHA9) is the only complete gene in the critical region, its biological role is not yet known and there are no data supporting its involvement in mammalian limb development. We have generated knockout mice in which only the entire coding region of Fingerin was deleted, and indeed found that most null mice display some limb defects. These include various levels of simple asymmetrical syndactyly, characterized by webbed fingers, generated by incomplete separation of soft, but not skeletal, tissues between forelimb digits 2 and 3. As expected, hand pads of Fingerin null embryos exhibited reduced apoptosis between digital rays 2 and 3. This defect was shown to cause syndactyly when the same limbs were grown ex vivo following the apoptosis assay. Extrapolating from mouse data, we suggest that Fingerin loss-of-function in humans may underlie MSSD syndactyly (OMIM 609432), which was mapped to the same locus. Taken together, Fingerin gene dosage links two different congenital limb malformations, syndactyly and ectrodactyly, which were previously postulated to share a common etiology. These results add limb disorders to the growing list of diseases resulting from CNV. PMID:24852374

  1. Factors affecting parasitism by Microctonus aethiopoides (Hymenoptera: Braconidae) and parasitoid development in natural and novel host species.

    Science.gov (United States)

    Barratt, B I; Johnstone, P D

    2001-08-01

    A laboratory study of aspects of parasitoid host acceptance, suitability and physiological regulation in natural and novel host species was carried out to investigate the degree of variability encountered with different hosts and to determine the value of such observations in host range determination. The parasitoid Microctonus aethiopoides Loan was exposed to a natural host, Sitona discoideus Gyllenhal (Coleoptera: Curculionidae) and three novel hosts, the New Zealand native Nicaeana cervina Broun, the introduced weed biological control agent Rhinocyllus conicus (Froehlich), and a congeneric pest species, Sitona lepidus Gyllenhal (all Coleoptera: Curculionidae). Per cent parasitism of these species was 54%, 43%, 39% and 0%, respectively. The results indicated that for both S. discoideus and R. conicus more males than females were parasitized (69% cf. 45%, and 49% cf. 32% respectively) but host size was not a significant factor. Overall, superparasitism was recorded in about 29% of parasitized weevils and there was evidence that host discrimination to avoid superparasitism occurred in the natural host. Conversely, superparasitism occurred more frequently than would be expected in N. cervina (42%) coupled with higher survival of larvae in superparasitized hosts in this species. The frequency distribution of attack of R. conicus by M. aethiopoides was not different from random. Parasitoid development was more rapid in the natural host, S. discoideus, and parasitoid size was positively correlated with host size. There was a strong positive relationship between parasitoid larval survival and the presence of teratocytes in all hosts. Host fecundity and fertility were reduced by parasitism for most species, and in some cases, by exposure to parasitoids in the absence of detectable parasitism. It was concluded that laboratory observations can provide useful information on the compatibility between host and parasitoid which can complement traditional host range tests to

  2. NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.

    Directory of Open Access Journals (Sweden)

    Lars Knudsen

    Full Text Available RATIONALE: Surfactant protein D (SP-D has important immuno-modulatory properties. The absence of SP-D results in an inducible NO synthase (iNOS, coded by NOS2 gene related chronic inflammation, development of emphysema-like pathophysiology and alterations of surfactant homeostasis. OBJECTIVE: In order to test the hypothesis that SP-D deficiency related abnormalities in pulmonary structure and function are a consequence of iNOS induced inflammation, we generated SP-D and iNOS double knockout mice (DiNOS. METHODS: Structural data obtained by design-based stereology to quantify the emphysema-like phenotype and disturbances of the intracellular surfactant were correlated to invasive pulmonary function tests and inflammatory markers including activation markers of alveolar macrophages and compared to SP-D (Sftpd(-/- and iNOS single knockout mice (NOS2(-/- as well as wild type (WT littermates. MEASUREMENTS AND RESULTS: DiNOS mice had reduced inflammatory cells in BAL and BAL-derived alveolar macrophages showed an increased expression of markers of an alternative activation as well as reduced inflammation. As evidenced by increased alveolar numbers and surface area, emphysematous changes were attenuated in DiNOS while disturbances of the surfactant system remained virtually unchanged. Sftpd(-/- demonstrated alterations of intrinsic mechanical properties of lung parenchyma as shown by reduced stiffness and resistance at its static limits, which could be corrected by additional ablation of NOS2 gene in DiNOS. CONCLUSION: iNOS related inflammation in the absence of SP-D is involved in the emphysematous remodeling leading to a loss of alveoli and associated alterations of elastic properties of lung parenchyma while disturbances of surfactant homeostasis are mediated by different mechanisms.

  3. General chemistry courses that can affect achievement: An action research study in developing a plan to improve undergraduate chemistry courses

    Science.gov (United States)

    Shweikeh, Eman

    Over the past 50 years, considerable research has been dedicated to chemistry education. In evaluating principal chemistry courses in higher education, educators have noted the learning process for first-year general chemistry courses may be challenging. The current study investigated perceptions of faculty, students and administrators on chemistry education at three institutions in Southern California. Via action research, the study sought to develop a plan to improve student engagement in general chemistry courses. A mixed method was utilized to analyze different perceptions on key factors determining the level of commitment and engagement in general chemistry education. The approach to chemistry learning from both a faculty and student perspective was examined including good practices, experiences and extent of active participation. The research study considered well-known measures of effective education with an emphasis on two key components: educational practices and student behavior. Institutional culture was inclusively assessed where cognitive expectations of chemistry teaching and learning were communicated. First, the extent in which faculty members are utilizing the "Seven Principles for Good Practice in Undergraduate Education" in their instruction was explored. Second, student attitudes and approaches toward chemistry learning were examined. The focus was on investigating student understanding of the learning process and the structure of chemistry knowledge. The seven categories used to measure students' expectations for learning chemistry were: effort, concepts, math link, reality link, outcome, laboratory, and visualization. This analysis represents the views of 16 faculty and 140 students. The results validated the assertion that students need some competencies and skills to tackle the challenges of the chemistry learning process to deeply engage in learning. A mismatch exists between the expectations of students and those of the faculty

  4. Factors affecting the development of adverse drug reactions to β-blockers in hospitalized cardiac patient population

    Directory of Open Access Journals (Sweden)

    Mugoša S

    2016-08-01

    Full Text Available Snežana Mugoša,1,2 Nataša Djordjević,3 Nina Djukanović,4 Dragana Protić,5 Zoran Bukumirić,6 Ivan Radosavljević,7 Aneta Bošković,8 Zoran Todorović5,9 1Department of Pharmacotherapy, Faculty of Pharmacy, University of Montenegro, 2Clinical Trial Department, Agency for Medicines and Medical Devices of Montenegro, Podgorica, Montenegro; 3Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 4High Medical School “Milutin Milanković”, Belgrade, 5Department of Pharmacology, Clinical Pharmacology and Toxicology, 6Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, 7Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 8Clinic for Heart Diseases, Clinical Centre of Montenegro, Podgorica, Montenegro; 9Department of Clinical Immunology and Allergy, Medical Center “Bežanijska kosa”, Belgrade, Serbia Abstract: The aim of the present study was to undertake a study on the prevalence of cytochrome P450 2D6 (CYP2D6 poor metabolizer alleles (*3, *4, *5, and *6 on a Montenegrin population and its impact on developing adverse drug reactions (ADRs of β-blockers in a hospitalized cardiac patient population. A prospective study was conducted in the Cardiology Center of the Clinical Center of Montenegro and included 138 patients who had received any β-blocker in their therapy. ADRs were collected using a specially designed questionnaire, based on the symptom list and any signs that could point to eventual ADRs. Data from patients’ medical charts, laboratory tests, and other available parameters were observed and combined with the data from the questionnaire. ADRs to β-blockers were observed in 15 (10.9% patients. There was a statistically significant difference in the frequency of ADRs in relation to genetically determined enzymatic activity (P<0.001, with ADRs’ occurrence significantly

  5. Affect Regulation

    DEFF Research Database (Denmark)

    Pedersen, Signe Holm; Poulsen, Stig Bernt; Lunn, Susanne

    2014-01-01

    Gergely and colleagues’ state that their Social Biofeedback Theory of Parental Affect Mirroring” can be seen as a kind of operationalization of the classical psychoanalytic concepts of holding, containing and mirroring. This article examines to what extent the social biofeedback theory of parenta...

  6. Developing an environmentally appropriate, socially acceptable and gender-sensitive technology for safe-water supply to households in arsenic affected areas in rural Bangladesh

    OpenAIRE

    Amin, N

    2010-01-01

    To confront the arsenic crisis in Bangladesh, several options for a safe water supply in the rural As-affected areas are available. Most of these options have shown a minimum scope to mitigate arsenic-related risks because of their poor performance and non-acceptability by the rural households. In this research, therefore, the development of an appropriate technology for an As-free, safe drinking water supply is considered from a local perspective and a societal context. To achieve the goal a...

  7. Affective Urbanism

    DEFF Research Database (Denmark)

    Samson, Kristine

    , experience and consumption are all strategic design tools applied by planners and architects. Whereas urban design in former modernist planning served merely functional or political means, urban design has increasingly become an aesthetical mediator of ideologies embedded in the urban field of life forces...... capitalism not only changes urban life and its means of production, it specifically influences the way the city is designed and how it unfolds as events (Anderson & Harrison 2010) and affective, emotional production (Pile 2009). Through examples of urban design and events in the Carlsberg City in Copenhagen...... and The High Line in Chelsea, New York, the paper sets out to define and question these affective modes of production. Whether these productions are socio-material practices consisting of ludic designs (Stevens 2007), temporary architecture or art installations or evental practices consisting of...

  8. A Study of Models of Life Quality Development of Isan Marginal Communities as Affected by Installation of the Solar Home System

    Directory of Open Access Journals (Sweden)

    Pongsil Simvised

    2008-01-01

    Full Text Available Problem Statement: The electricity production system by using solar home cells is regarded as a substitute for energy which the state provides for the marginal communities because the area cannot be extended for putting up pylons with electric cables, all this for the marginal communities to have better life and being. The purposes of this thesis were to examine the history and development of the electricity production system by using solar home cells, and to examine models of life quality of Isan marginal communities as affected by the use of solar home system by using solar home cells. Approach: The sample consisted of 100 people in Isan marginal communities who lived in mountains, on highlands, on lowlands, and in national park areas with totally 4 areas. The instruments used for collecting data were an observation form, an interview form a group discourse note-taking form and workshop note-taking form. The 6 aspects of Minimum Needs (MN was included into every instrument. The data analysis results were subsequently presented by means of a descriptive analysis: Results: 1for the history and development of the solar home system, it was found that Thailand began using solar cells in 1977 by the Unit of Volunteer Doctors. At present, solar cells are used in various types: battery charging stations, communication systems, water pumping system, traffic light signals, blinkers and electric systems in marginal communities in general.2 for the models of life quality development of Isan marginal communities as affected by the use of the solar home system, the life quality was developed according to indicators of maximum needs in these 6 aspects: the model of developing good health, the model of developing progressive incomes, the models of This value cultivation and the model of developing cooperative development. It was found that the positive effects were at 98.67% and negative effects were at only 1.33%. Conclusion/Recommendation: There for, it can

  9. Analytical method development for powder characterization: Visualization of the critical drug loading affecting the processability of a formulation for direct compression.

    Science.gov (United States)

    Hirschberg, Cosima; Sun, Changquan Calvin; Rantanen, Jukka

    2016-09-01

    Characterization of particulate systems (powders) is one of the remaining scientific challenges. Evaluation of powder behaviour is often empirical and the decision-making processes are experience-based. There is a need for development of analytical instrumentation enabling more fundamental understanding of powder behaviour. Flowability and tabletability, two key factors in commercial scale manufacturing of tablets with direct compression (DC) approach, were analysed for formulations containing increasing amounts of several model active pharmaceutical ingredients (APIs). Flowability was investigated using a ring shear tester and tablets were prepared at four different compression pressures using a single punch tablet press. Thereby, a material sparing screening approach was developed to estimate the influence of APIs on behaviour of a given DC formulation. Additionally, this approach is useful for estimating the low threshold amount of API (wt%), at which the properties of an API start affecting the powder behaviour of a given formulation (API-excipient mixture). This threshold will be referred to as critical drug loading. The flowability of microcrystalline cellulose (reference grade pH 102) was used as a threshold for adequate flowability of model formulations. The threshold for tablet tensile strength was set to 2MPa. Simultaneous visual presentation of both- flowability and tabletability were used for a fast evaluation of manufacturability of a given formulation. The results confirmed that flowability is more sensitive to drug loading than tabletability, and that the critical drug loading for a DC formulation is strongly affected by particulate properties of API. For example, decreasing the particle size of paracetamol led to rapid decrease in flowability index, whereas the tabletability was not affected. PMID:27368089

  10. Family-based HIV prevention and intervention services for youth living in poverty-affected contexts: the CHAMP model of collaborative, evidence-informed programme development

    Directory of Open Access Journals (Sweden)

    Bhana Arvin

    2010-06-01

    Full Text Available Abstract Family-based interventions with children who are affected by HIV and AIDS are not well established. The Collaborative HIV Prevention and Adolescent Mental Health Program (CHAMP represents one of the few evidence-based interventions tested in low-income contexts in the US, Caribbean and South Africa. This paper provides a description of the theoretical and empirical bases of the development and implementation of CHAMP in two of these countries, the US and South Africa. In addition, with the advent of increasing numbers of children infected with HIV surviving into adolescence and young adulthood, a CHAMP+ family-based intervention, using the founding principles of CHAMP, has been developed to mitigate the risk influences associated with being HIV positive.

  11. An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

    International Nuclear Information System (INIS)

    Bisphenol A (BPA) is widely used industrially to produce polycarbonate plastics and epoxy resins. Numerous studies document the harmful effects caused by low-dose BPA exposure especially on nervous systems and behavior in experimental animals such as mice and rats. Here, we exposed embryos of a model chordate, Ciona intestinalis, to seawater containing BPA to evaluate adverse effects on embryonic development and on the swimming behavior of subsequent larvae. Ciona is ideal because its larva develops rapidly and has few cells. The rate of larval hatching decreased in a dose-dependent manner with exposures to BPA above 3 μM; swimming behavior was also affected in larvae emerging from embryos exposed to 1 μM BPA. Adverse effects were most severe on fertilized eggs exposed to BPA within 7 h post-fertilization. Ciona shares twelve nuclear receptors with mammals, and BPA is proposed to disturb the physiological functions of one or more of these. - Highlights: ► Embryos of Ciona intestinalis were exposed to BPA to evaluate its developmental effects. ► The rate of larval hatching decreased in a dose-dependent manner. ► Swimming behavior was affected in larvae that emerge from embryos exposed to 1 μM BPA. ► Our findings will support a new strategy to analyze the developmental effects induced by BPA. - Exposure of fertilized Ciona embryos to BPA decreased their hatch rate in a dose-dependent manner and led to abnormal larval swimming behavior.

  12. Affective Maps

    DEFF Research Database (Denmark)

    Salovaara-Moring, Inka

    Recently, in human geography there has been a considerable attention paid to retheorising maps; less as a product and more as practice. This refers to the notion that rather than reading maps as fixed representations, digital mapping is by nature a dynamic, performative, and participatory practice....... In particular, mapping environmental damage, endangered species, and human made disasters has become one of the focal point of affective knowledge production. These ‘more-than-humangeographies’ practices include notions of species, space and territory, and movement towards a new political ecology...

  13. Exposure to altered gravity during specific developmental periods differentially affects growth, development, the cerebellum and motor functions in male and female rats

    Science.gov (United States)

    Nguon, K.; Ladd, B.; Sajdel-Sulkowska, E. M.

    2006-01-01

    We previously reported that perinatal exposure to hypergravity affects cerebellar structure and motor coordination in rat neonates. In the present study, we explored the hypothesis that neonatal cerebellar structure and motor coordination may be particularly vulnerable to the effects of hypergravity during specific developmental stages. To test this hypothesis, we compared neurodevelopment, motor behavior and cerebellar structure in rat neonates exposed to 1.65 G on a 24-ft centrifuge during discrete periods of time: the 2nd week of pregnancy [gestational day (G) 8 through G15; group A], the 3rd week of pregnancy (G15 through birth on G22/G23; group B), the 1st week of nursing [birth through postnatal day (P) 6; group C], the 2nd and 3rd weeks of nursing (P6 through P21; group D), the combined 2nd and 3rd weeks of pregnancy and nursing (G8 through P21; group E) and stationary control (SC) neonates (group F). Prenatal exposure to hypergravity resulted in intrauterine growth retardation as reflected by a decrease in the number of pups in a litter and lower average mass at birth. Exposure to hypergravity immediately after birth impaired the righting response on P3, while the startle response in both males and females was most affected by exposure during the 2nd and 3rd weeks after birth. Hypergravity exposure also impaired motor functions, as evidenced by poorer performance on a rotarod; while both males and females exposed to hypergravity during the 2nd and 3rd weeks after birth performed poorly on P21, male neonates were most dramatically affected by exposure to hypergravity during the second week of gestation, when the duration of their recorded stay on the rotarod was one half that of SC males. Cerebellar mass was most reduced by later postnatal exposure. Thus, for the developing rat cerebellum, the postnatal period that overlaps the brain growth spurt is the most vulnerable to hypergravity. However, male motor behavior is also affected by midpregnancy exposure to

  14. Affective and Cognitive Characteristics of Nigerian Student-Teachers : Towards Developing an Effective Teacher Education Framework development network second phase>

    OpenAIRE

    Adeosun, Oyenike; Oni, Soji; Oladipo, Bayo

    2013-01-01

    The study analyzes the affective and cognitive traits of teacher trainees in higher educational institutions in Nigeria. This is with the view to develop an effective teacher education framework by using inputs from the trainees, in-service teachers and teacher educators and incorporate their ideas into the structuring and organization of not only the educational programmes but also the admission processes into such programmes. Using inputs from classroom teachers, teacher trainees, teacher e...

  15. Overexpression of the kiwifruit SVP3 gene affects reproductive development and suppresses anthocyanin biosynthesis in petals, but has no effect on vegetative growth, dormancy, or flowering time.

    Science.gov (United States)

    Wu, Rongmei; Wang, Tianchi; McGie, Tony; Voogd, Charlotte; Allan, Andrew C; Hellens, Roger P; Varkonyi-Gasic, Erika

    2014-09-01

    SVP-like MADS domain transcription factors have been shown to regulate flowering time and both inflorescence and flower development in annual plants, while having effects on growth cessation and terminal bud formation in perennial species. Previously, four SVP genes were described in woody perennial vine kiwifruit (Actinidia spp.), with possible distinct roles in bud dormancy and flowering. Kiwifruit SVP3 transcript was confined to vegetative tissues and acted as a repressor of flowering as it was able to rescue the Arabidopsis svp41 mutant. To characterize kiwifruit SVP3 further, ectopic expression in kiwifruit species was performed. Ectopic expression of SVP3 in A. deliciosa did not affect general plant growth or the duration of endodormancy. Ectopic expression of SVP3 in A. eriantha also resulted in plants with normal vegetative growth, bud break, and flowering time. However, significantly prolonged and abnormal flower, fruit, and seed development were observed, arising from SVP3 interactions with kiwifruit floral homeotic MADS-domain proteins. Petal pigmentation was reduced as a result of SVP3-mediated interference with transcription of the kiwifruit flower tissue-specific R2R3 MYB regulator, MYB110a, and the gene encoding the key anthocyanin biosynthetic step, F3GT1. Constitutive expression of SVP3 had a similar impact on reproductive development in transgenic tobacco. The flowering time was not affected in day-neutral and photoperiod-responsive Nicotiana tabacum cultivars, but anthesis and seed germination were significantly delayed. The accumulation of anthocyanin in petals was reduced and the same underlying mechanism of R2R3 MYB NtAN2 transcript reduction was demonstrated. PMID:24948678

  16. Factors affecting study efficiency and item non-response in health surveys in developing countries: the Jamaica national healthy lifestyle survey

    Directory of Open Access Journals (Sweden)

    Bennett Franklyn

    2007-02-01

    Full Text Available Abstract Background Health surveys provide important information on the burden and secular trends of risk factors and disease. Several factors including survey and item non-response can affect data quality. There are few reports on efficiency, validity and the impact of item non-response, from developing countries. This report examines factors associated with item non-response and study efficiency in a national health survey in a developing Caribbean island. Methods A national sample of participants aged 15–74 years was selected in a multi-stage sampling design accounting for 4 health regions and 14 parishes using enumeration districts as primary sampling units. Means and proportions of the variables of interest were compared between various categories. Non-response was defined as failure to provide an analyzable response. Linear and logistic regression models accounting for sample design and post-stratification weighting were used to identify independent correlates of recruitment efficiency and item non-response. Results We recruited 2012 15–74 year-olds (66.2% females at a response rate of 87.6% with significant variation between regions (80.9% to 97.6%; p Conclusion Informative health surveys are possible in developing countries. While survey response rates may be satisfactory, item non-response was high in respect of income and sexual practice. In contrast to developed countries, non-response to questions on income is higher and has different correlates. These findings can inform future surveys.

  17. PENICILLIN-STREPTOMYCIN IN THE CULTURE MEDIUM DURING IN VITRO MATURATION (IVM OF BOVINE OOCYTES AFFECTS NUCLEAR MATURATION AND SUBSEQUENT EMBRYO DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    SHIRAZI A

    2001-01-01

    Full Text Available Introduction: Standard concentrations of antibiotics in culture media are thought to have no detectable toxic effects on the cultured cells. However, since antibiotics are biologically active substances, the possibility that they interfere to some extent with cellular processes occurring in the cultured cells can not always be totally excluded. This study, therefore, was conducted to assess whether the presence of penicllin-streptomycin (pen-strep during in vitro maturation (IVM of bovine cumulus oocyte complexes (COCs affect nuclear and cytoplasmic maturation and subsequent embryo development. Materials and Methods: Bovine COCs were matured at 39oC in a humidified atmosphere with 5 % CO2 in air for 24 h in: 1- culture medium M 199 supplemented with 10 % FCS (Fetal calf serum, 0.05 IU/ml rhFSH (recombinant human FSH and 100 units penicillin and 100 ?g streptomycin/ ml. 2- culture medium M 199 without FCS and rhFSH in the presence of pen-strep. Cultures without antibiotics served as control. Six series of experiments, each consisted of at least 3 replicates, were performed. Results: In vitro maturation in the presence of pen-strep in culture medium supplemented with FCS and rhFSH significantly (P<0.05 increased the percentage of MII oocytes, however, when the COCs were divided, on the basis of appearance of the cumulus investment, into bright and dark groups, this effect was less obvious in both types of COCs, 76% vs 72% in bright COCs (P= 0.149 or 83% vs 80% in dark COCs (P=0.296 in treated and control groups respectively. The percentage of oocytes with type III of cortical granules (CGs distribution was not affected in the presence of pen-strep. The COCs expansion after IVM was not affected by the presence of antibiotics in culture medium. The subsequent embryo development of IVM/IVF produced ova, which were exposed to pen-strep during IVM, was significantly (P<0.05 decreased with respect to blastocyst formation by day 9. In vitro maturation in

  18. Can consumer choice replace trust in the National Health Service in England? Towards developing an affective psychosocial conception of trust in health care.

    Science.gov (United States)

    Fotaki, Marianna

    2014-11-01

    Trust has long been regarded as a vitally important aspect of the relationship between health service providers and patients. Recently, consumer choice has been increasingly advocated as a means of improving the quality and effectiveness of health service provision. However, it is uncertain how the increase of information necessary to allow users of health services to exercise choice, and the simultaneous introduction of markets in public health systems, will affect various dimensions of trust, and how changing relations of trust will impact upon patients and services. This article employs a theory-driven approach to investigate conceptual and material links between choice, trust and markets in health care in the context of the National Health Service in England. It also examines the implications of patient choice on systemic, organisational and interpersonal trust. The article is divided into two parts. The first argues that the shift to marketisation in public health services might lead to an over-reliance on rational-calculative aspects of trust at the expense of embodied, relational and social attributes. The second develops an alternative psychosocial conception of trust: it focuses on the central role of affect and accounts for the material and symbolic links between choice, trust and markets in health care. PMID:25470326

  19. Affectivity in the Liminal

    DEFF Research Database (Denmark)

    Thomassen, Bjørn

    alternative interpretations of what liminality is, or could be, taking it to territories distant from its place of origin, quite the contrary: we are moving the concept back to its rightful place in intellectual history and back to the core of its significance, back to the centre of human emotions trembling......In this paper I propose a return to the work of Arnold van Gennep, in order to briefly discuss how the terms of liminality and affectivity were always already connected. By linking the concept of liminality that van Gennep made famous to affectivity, we are actually not proposing new and...... at the threshold. The paper contains three sections: a) liminality and affectivity in van Gennep’s life; b) liminality and affectivity as a theme in his work; c) liminality and affectivity as developed in the early reception of his work....

  20. Dietary Patterns in Pregnancy and Effects on Nutrient Intake in the Mid-South: The Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE Study

    Directory of Open Access Journals (Sweden)

    Frances A. Tylavsky

    2013-05-01

    Full Text Available Dietary patterns are sensitive to differences across socio-economic strata or cultural habits and may impact programing of diseases in later life. The purpose of this study was to identify distinct dietary patterns during pregnancy in the Mid-South using factor analysis. Furthermore, we aimed to analyze the differences in the food groups and in macro- and micronutrients among the different food patterns. The study was a cross-sectional analysis of 1155 pregnant women (mean age 26.5 ± 5.4 years; 62% African American, 35% Caucasian, 3% Other; and pre-pregnancy BMI 27.6 ± 7.5 kg/m2. Using food frequency questionnaire data collected from participants in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE study between 16 and 28 weeks of gestation, dietary patterns were identified using factor analysis. Three major dietary patterns, namely, Healthy, Processed, and US Southern were identified among pregnant women from the Mid-South. Further analysis of the three main patterns revealed four mixed dietary patterns, i.e., Healthy-Processed, Healthy-US Southern, Processed-US Southern, and overall Mixed. These dietary patterns were different (p < 0.001 from each other in almost all the food items, macro- and micro nutrients and aligned across socioeconomic and racial groups. Our study describes unique dietary patterns in the Mid-South, consumed by a cohort of women enrolled in a prospective study examining the association of maternal nutritional factors during pregnancy that are known to affect brain and cognitive development by age 3.

  1. Does hardness of food affect the development of pharyngeal teeth of the black carp, Mylopharyngodon piceus (Pisces: Cyprinidae)?

    DEFF Research Database (Denmark)

    Hung, Nguyen Manh; Ryan, Timothy M.; Stauffer, Jay R.;

    2015-01-01

    We investigated whether food type influences development of the pharyngeal crushing apparatus of black carp (Mylopharyngodon piceus, Cyprinidae). Fish fed a hard diet had average standard lengths and weights larger than those fed a soft diet; these observations in part could be related to differe...... if black carp are produced for snail control, a hard diet should be provided from an as early time as possible in the production cycle.......We investigated whether food type influences development of the pharyngeal crushing apparatus of black carp (Mylopharyngodon piceus, Cyprinidae). Fish fed a hard diet had average standard lengths and weights larger than those fed a soft diet; these observations in part could be related...... of the pharyngeal teeth were greater in fish fed hard diets than in those fed soft diets. Total weights of the pharyngeal arches were less in the fish fed a soft diet than in those fed a hard diet. These results indicated that food type affects development of the pharyngeal crushing mill of black carp and therefore...

  2. Ovarian development in a primitively eusocial wasp: social interactions affect behaviorally dominant and subordinate wasps in opposite directions relative to solitary females.

    Science.gov (United States)

    Shukla, Shantanu; Pareek, Vidhi; Gadagkar, Raghavendra

    2014-07-01

    In many primitively eusocial wasp species new nests are founded either by a single female or by a small group of females. In the single foundress nests, the lone female develops her ovaries, lays eggs as well as tends her brood. In multiple foundress nests social interactions, especially dominance-subordinate interactions, result in only one 'dominant' female developing her ovaries and laying eggs. Ovaries of the remaining 'subordinate' cofoundresses remain suppressed and these individuals function as workers and tend the dominant's brood. Using the tropical, primitively eusocial polistine wasp Ropalidia marginata and by comparing wasps held in isolation and those kept as pairs in the laboratory, we demonstrate that social interactions affect ovarian development of dominant and subordinate wasps among the pairs in opposite directions, suppressing the ovaries of the subordinate member of the pair below that of solitary wasps and boosting the ovaries of dominant member of the pair above that of solitary females. In addition to being of physiological interest, such mirror image effects of aggression on the ovaries of the aggressors and their victims, suggest yet another mechanism by which subordinates can enhance their indirect fitness and facilitate the evolution of worker behavior by kin selection. PMID:24747068

  3. Cardiac Arrest-Induced Global Brain Hypoxia-Ischemia during Development Affects Spontaneous Activity Organization in Rat Sensory and Motor Thalamocortical Circuits during Adulthood.

    Science.gov (United States)

    Shoykhet, Michael; Middleton, Jason W

    2016-01-01

    Normal maturation of sensory information processing in the cortex requires patterned synaptic activity during developmentally regulated critical periods. During early development, spontaneous synaptic activity establishes required patterns of synaptic input, and during later development it influences patterns of sensory experience-dependent neuronal firing. Thalamocortical neurons occupy a critical position in regulating the flow of patterned sensory information from the periphery to the cortex. Abnormal thalamocortical inputs may permanently affect the organization and function of cortical neuronal circuits, especially if they occur during a critical developmental window. We examined the effect of cardiac arrest (CA)-associated global brain hypoxia-ischemia in developing rats on spontaneous and evoked firing of somatosensory thalamocortical neurons and on large-scale correlations in the motor thalamocortical circuit. The mean spontaneous and sensory-evoked firing rate activity and variability were higher in CA injured rats. Furthermore, spontaneous and sensory-evoked activity and variability were correlated in uninjured rats, but not correlated in neurons from CA rats. Abnormal activity patterns of ventroposterior medial nucleus (VPm) neurons persisted into adulthood. Additionally, we found that neurons in the entopeduncular nucleus (EPN) in the basal ganglia had lower firing rates yet had higher variability and higher levels of burst firing after injury. Correlated levels of power in local field potentials (LFPs) between the EPN and the motor cortex (MCx) were also disrupted by injury. Our findings indicate that hypoxic-ischemic injury during development leads to abnormal spontaneous and sensory stimulus-evoked input patterns from thalamus to cortex. Abnormal thalamic inputs likely permanently and detrimentally affect the organization of cortical circuitry and processing of sensory information. Hypoxic-ischemic injury also leads to abnormal single neuron and

  4. Development of mental health first aid guidelines on how a member of the public can support a person affected by a traumatic event: a Delphi study

    Directory of Open Access Journals (Sweden)

    Kitchener Betty A

    2010-06-01

    Full Text Available Abstract Background People who experience traumatic events have an increased risk of developing a range of mental disorders. Appropriate early support from a member of the public, whether a friend, family member, co-worker or volunteer, may help to prevent the onset of a mental disorder or may minimise its severity. However, few people have the knowledge and skills required to assist. Simple guidelines may help members of the public to offer appropriate support when it is needed. Methods Guidelines were developed using the Delphi method to reach consensus in a panel of experts. Experts recruited to the panels included 37 professionals writing, planning or working clinically in the trauma area, and 17 consumer or carer advocates who had been affected by traumatic events. As input for the panels to consider, statements about how to assist someone who has experienced a traumatic event were sourced through a systematic search of both professional and lay literature. These statements were used to develop separate questionnaires about possible ways to assist adults and to assist children, and panel members answered either one questionnaire or both, depending on experience and expertise. The guidelines were written using the items most consistently endorsed by the panels across the three Delphi rounds. Results There were 180 items relating to helping adults, of which 65 were accepted, and 155 items relating to helping children, of which 71 were accepted. These statements were used to develop the two sets of guidelines appended to this paper. Conclusions There are a number of actions which may be useful for members of the public when they encounter someone who has experienced a traumatic event, and it is possible that these actions may help prevent the development of some mental health problems in the future. Positive social support, a strong theme in these guidelines, has some evidence for effectiveness in developing mental health problems in people

  5. Timing of eclosion affects diapause development, fat body consumption and longevity in Osmia lignaria, a univoltine, adult-wintering solitary bee.

    Science.gov (United States)

    Bosch, Jordi; Sgolastra, Fabio; Kemp, William P

    2010-12-01

    Most insects from temperate areas enter diapause ahead of winter. Species diapausing in a feeding stage and accumulating metabolic reserves during permissive pre-wintering conditions are expected to enter diapause shortly before the onset of winter. In contrast, species diapausing in a non-feeding stage are expected to lower their metabolism as soon as possible to avoid excessive consumption of metabolic reserves. The solitary bee Osmia lignaria winters as a non-feeding adult within its cocoon, but previous studies show important weight losses and increased winter mortality in populations pre-wintered for extended periods. We measured respiration rates to assess diapause initiation and maintenance during pre-wintering, and tested whether timing of adult eclosion affected fitness by measuring fat body depletion, winter mortality and post-winter longevity. We worked with different cohorts of a population reared under natural conditions, and manipulated pre-wintering duration in a population reared under artificial conditions. In agreement with our expectation, O. lignaria lower their metabolic rates within a few days of adult eclosion, but nonetheless suffer strong weight loss during pre-wintering. Early developing individuals suffer greater weight loss and fat body depletion, and have short post-winter longevity. Although, we found no differences in winter mortality among treatments, our results indicate that increased mortality may occur in years with late winter arrivals. We discuss fundamental ecophysiological differences between adult and prepupal diapause within the Megachilidae, and hypothesize that species wintering as adults will be more negatively affected by a situation of extended summers under a scenario of global warming. PMID:20816851

  6. Factors Affecting Adoption of Agroforestry Farming System as a Mean for Sustainable Agricultural Development and Environment Conservation in Arid Areas of Northern Kordofan State, Sudan

    International Nuclear Information System (INIS)

    Arid and semi-arid areas represent about 60 percent of Sudan total area. One of the main environmental problems in the arid and semi-arid areas is diffraction's which reduces the natural potential of the already fragile ecosystems and renders rural people vulnerable to food shortages, the vagaries of weather and natural disasters. Deforestation which is considered one of the most critical environmental problems facing the world is one of the main causes of diffraction's. Between the years 1990 and 2005 Sudan lost about 8.8 millions hectares of forests, which represents 11%, of its forests mainly because of subsistence activities such as overgrazing, trees cutting and expansion of traditional agriculture. One of the areas that are very much affected by diffraction's is Northern Kordofan State. To rescue the situation the government of Sudan, with assistance from the United Nations Development Program (UNDP) and some donors, implemented a project that aimed primarily at restocking Acacia Senegal trees in Northern Kordofan State. This study is intended to explore the factors that caused differential rate of farmers' adoption rate of the Acacia Senegal based agroforestry farming system. The study data was collected from a clustered random sample of 300 farmers, through face to face interviews using a questionnaire that was pre-tested and validated. Frequency distribution and multiple regression analysis were used to analyze the data. It has been found that farmers' adoption of agroforestry farming system in Northern Kordofan state was significantly affected by the farmers' level of formal education, contact with extension agents, level of environmental awareness, cosmopoliteness, total area of owned land and extent of social participation. (author)

  7. A modeling study of the physical processes affecting the development of seasonal hypoxia over the inner Louisiana-Texas shelf: Circulation and stratification

    Science.gov (United States)

    Wang, Lixia; Justić, Dubravko

    2009-06-01

    The physical processes affecting the development of seasonal hypoxia over the Louisiana-Texas shelf were examined using a high-resolution, three-dimensional, unstructured-grid, Finite Volume Coastal Ocean Model (FVCOM). The model was forced with the observed freshwater fluxes from the Mississippi and Atchafalaya Rivers, surface winds, heat fluxes, tides and offshore conditions. The simulations were carried out over a six-month period, from April to September 2002, and the model performance was evaluated against several independent series of observations that included tidal gauge data, Acoustic Doppler Current Profiler (ADCP) data, shipboard measurements of temperature and salinity, vertical salinity and sigma-t profiles, and satellite imagery. The model accurately described the offshore circulation mode generated over the Louisiana-Texas shelf by the westerly winds during summer months, as well as the prevalent westward flow along the coast caused by the easterly winds during the rest of the study period. The seasonal cycle of stratification also was well represented by the model. During 2002, the stratification was initiated in early spring and subsequently enhanced by the intensity and phasing of riverine freshwater discharges. Strong stratification persisted throughout the summer and was finally broken down in September by tropical storms. The model simulations also revealed a quasi-permanent anticyclonic gyre in the Louisiana Bight region formed by the rotational transformation of the Mississippi River plume, whose existence during 2002 was supported by the satellite imagery and ADCP current measurements. Model simulations support the conclusion that local wind forcing and buoyancy flux resulting from riverine freshwater discharges were the dominant mechanisms affecting the circulation and stratification over the inner Louisiana-Texas shelf.

  8. Pain, Affect, and Attachment

    Directory of Open Access Journals (Sweden)

    Carl Eduard Scheidt

    2015-03-01

    Full Text Available Various psychodynamic processes may underlie the development of psychogenic pain disorder such as conversion, the displacement of affect, or narcissistic defenses. However, many of the processes suggested are related to a disorder of affect regulation. The term affect regulation in psychoanalytic literature refers to phenomena which are often described by the concept of alexithymia. Empirical observations suggest that alexithymia is correlated to insecure attachment, especially an insecure dismissing representation of attachment. Psychodynamic psychotherapy in psychogenic pain disorder should focus on the reintegration of split-off affects which may provoke intensive counter-transference and which in order to be used therapeutically must be linked to attachment experiences within and outside of the therapeutic relationship.

  9. Seismic air gun exposure during early-stage embryonic development does not negatively affect spiny lobster Jasus edwardsii larvae (Decapoda: Palinuridae).

    Science.gov (United States)

    Day, Ryan D; McCauley, Robert D; Fitzgibbon, Quinn P; Semmens, Jayson M

    2016-01-01

    Marine seismic surveys are used to explore for sub-seafloor oil and gas deposits. These surveys are conducted using air guns, which release compressed air to create intense sound impulses, which are repeated around every 8-12 seconds and can travel large distances in the water column. Considering the ubiquitous worldwide distribution of seismic surveys, the potential impact of exposure on marine invertebrates is poorly understood. In this study, egg-bearing female spiny lobsters (Jasus edwardsii) were exposed to signals from three air gun configurations, all of which exceeded sound exposure levels (SEL) of 185 dB re 1 μPa(2) · s. Lobsters were maintained until their eggs hatched and the larvae were then counted for fecundity, assessed for abnormal morphology using measurements of larval length and width, tested for larval competency using an established activity test and measured for energy content. Overall there were no differences in the quantity or quality of hatched larvae, indicating that the condition and development of spiny lobster embryos were not adversely affected by air gun exposure. These results suggest that embryonic spiny lobster are resilient to air gun signals and highlight the caution necessary in extrapolating results from the laboratory to real world scenarios or across life history stages. PMID:26947006

  10. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects tooth development in rhesus monkeys

    Energy Technology Data Exchange (ETDEWEB)

    Yasuda, Iku; Kazuhiro, Tsuga; Yasumasa, Akagawa [Hiroshima Univ. (Japan); Mineo, Yasuda; Hiroshi, Sumida [Hiroshima International Univ. (Japan); Akihiro, Arima; Toshio, Ihara [Shin Nippon Biomedical Laboratories, Ltd., Kagoshima (Japan); Shunichiro, Kubota [Tokyo Univ. (Japan); Kazuo, Asaoka [Kyoto Univ., Inuyama (Japan). Primate Research Institute; Takumi, Takasuga [Shimadzu Techno-Research Inc., Kyoto (Japan)

    2004-09-15

    The current tolerable daily intake (TDI) of dioxin and dioxin related compounds has been set at 4 pg TEQ/kg/day in Japan. This value was calculated from the lowest-observed-adverse-effect level (LOAEL) in experimental animals, mostly rodents. Gray et al. reported that a single oral dose of 200 ng/kg of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to pregnant rats on day 15 of gestation resulted in abnormalities of reproductive organs in the offspring. The maternal body burden at this dose was measured to be 86 ng/kg. To attain this body burden level, human daily intake was calculated to be 43.6 pg/kg/day. An uncertainty factor of 10 was applied to this value, and the human TDI was established. However, due to great differences in the biological half life of TCDD between human and rodents, the validity of this calculation is questioned. To obtain more reliable LOAEL in the second generation, we initiated a long-term study in rhesus monkeys in 1999. In rodents, teeth are known to be targets of developmental toxicity of dioxin. In utero and lactational TCDD exposure affects rat incisor and molar development. In humans also tooth abnormalities were reported among populations exposed to dioxins. In our monkey experiment, some young were stillborn or died neonatally. These animals provided us with a unique opportunity to study tooth development in primate young exposed to TCDD in utero and lactationally. By macroscopic observation we found some tooth abnormalities among died young exposed to TCDD5. This prompted us to examine surviving young by radiography. This is an interim report of our findings in these young.

  11. A gestational high protein diet affects the abundance of muscle transcripts related to cell cycle regulation throughout development in porcine progeny.

    Directory of Open Access Journals (Sweden)

    Michael Oster

    Full Text Available BACKGROUND: In various animal models pregnancy diets have been shown to affect offspring phenotype. Indeed, the underlying programming of development is associated with modulations in birth weight, body composition, and continual diet-dependent modifications of offspring metabolism until adulthood, producing the hypothesis that the offspring's transcriptome is permanently altered depending on maternal diet. METHODOLOGY/PRINCIPAL FINDINGS: To assess alterations of the offspring's transcriptome due to gestational protein supply, German Landrace sows were fed isoenergetic diets containing protein levels of either 30% (high protein--HP or 12% (adequate protein--AP throughout their pregnancy. Offspring muscle tissue (M. longissimus dorsi was collected at 94 days post conception (dpc, and 1, 28, and 188 days post natum (dpn for use with Affymetrix GeneChip Porcine Genome Arrays and subsequent statistical and Ingenuity pathway analyses. Numerous transcripts were found to have altered abundance at 94 dpc and 1 dpn; at 28 dpn no transcripts were altered, and at 188 dpn only a few transcripts showed a different abundance between diet groups. However, when assessing transcriptional changes across developmental time points, marked differences were obvious among the dietary groups. Depending on the gestational dietary exposure, short- and long-term effects were observed for mRNA expression of genes related to cell cycle regulation, energy metabolism, growth factor signaling pathways, and nucleic acid metabolism. In particular, the abundance of transcripts related to cell cycle remained divergent among the groups during development. CONCLUSION: Expression analysis indicates that maternal protein supply induced programming of the offspring's genome; early postnatal compensation of the slight growth retardation obvious at birth in HP piglets resulted, as did a permanently different developmental alteration and responsiveness to the common environment of the

  12. Auxin polar transport of etiolated Ageotropum pea epicotyls is not affected by gravistimulation: Relevance to automorphosis-like growth and development

    Science.gov (United States)

    Miyamoto, Kensuke; Hoshino, Tomoki; Takahashi, Yoshinori; Ueda, Junichi

    There appears to be a close relationship between automorphosis and changes in auxin polar transport due to the fact that microgravity conditions cause both changes in the activity of auxin polar transport and in automorphosis of etiolated Alaska pea epicotyls. In addition, the application of inhibitors of auxin polar transport results in automorphosis-like growth and development. To elucidate the role of auxin polar transport in gravimorphogenesis in etiolated pea seedlings, we have studied the effects of gravistimulation on growth and development, and auxin polar transport in epicotyls of an agravitropic pea mutant " Ageotropum" seedlings and the normal "Alaska" seedlings. When the embryo axes in seeds of Alaska pea were set in a vertical (parallel to the direction of gravity) or a horizontal (vertical to the direction of gravity) position, and allowed to germinate and grow under 1 g conditions in the dark for 3 or 6.5 days, the epicotyls grew upward due to negative gravitropic responses regardless of gravistimulation during seed germination. On the other hand, epicotyls of etiolated Ageotropum pea seedlings showed automorphosis-like bending away from the cotyledons regardless of gravistimulation during seed germination. Automorphosis-like epicotyl bending of etiolated Ageotropum pea seedlings was also unaffected by clinorotation on a three-dimensional (3-D) clinostat. The activity of auxin polar transport in the 2nd internodes of 6.5-d-old etiolated Ageotropum pea seedlings was lower than those of Alaska pea seedlings, and was not affected by clinorotation on a 3-D clinostat or by changes in gravity conditions during seed germination. These findings strongly support our previous studies that showed that normal auxin polar transport is required for the normal graviresponse of epicotyls in etiolated pea seedlings.

  13. Development of a Geo-Referenced Database for Weed Mapping and Analysis of Agronomic Factors Affecting Herbicide Resistance in Apera spica-venti L. Beauv. (Silky Windgrass

    Directory of Open Access Journals (Sweden)

    Dario Massa

    2013-01-01

    Full Text Available In this work, we evaluate the role of agronomic factors in the selection for herbicide resistance in Apera spica-venti L. Beauv. (silky windgrass. During a period of three years, populations were collected in more than 250 conventional fields across Europe and tested for resistance in the greenhouse. After recording the field history of locations, a geo-referenced database has been developed to map the distribution of herbicide-resistant A. spica-venti populations in Europe. A Logistic Regression Model was used to assess whether and to what extent agricultural and biological factors (crop rotation, soil tillage, sowing date, soil texture and weed density affect the probability of resistance selection apart from the selection pressure due to herbicide application. Our results revealed that rotation management and soil tillage are the factors that have the greatest influence on the model. In addition, first order interactions between these two variables were highly significant. Under conventional tillage, a percentage of winter crops in the rotation exceeding 75% resulted in a 1280-times higher risk of resistance selection compared to rotations with less than 50% of winter crops. Under conservation tillage, the adoption of >75% of winter crops increased the risk of resistance 13-times compared to rotations with less than 50% of winter crops. Finally, early sowing and high weed density significantly increased the risk of resistance compared to the reference categories (later sowing and low weed density, respectively. Soil texture had no significant influence. The developed model can find application in management programs aimed at preventing the evolution and spread of herbicide resistance in weed populations.

  14. 影响果蝇心脏发育的基因突变%Mutations of Genes Affecting Heart Development of Drosophila

    Institute of Scientific and Technical Information of China (English)

    李冬玲; 戴琦; 袁婺洲; 吴秀山; 李敏

    2001-01-01

    最近的研究表明,果蝇与脊椎动物及人的心脏早期发育具有极为相似的基因控制机理,果蝇已成为研究人体心脏早期发育基因控制的理想模式动物。利用化学诱变剂甲磺酸乙酯大规模地诱变影响果蝇心脏发育的基因,利用心脏特异性抗体染色进行筛选,获得了112个有心脏突变表型的致死系,其中32个致死系的心脏畸变表型有别于目前已知心脏发育基因的突变表型。细胞遗传学定位研究表明在多线染色体的13个带纹区内的某些隐性致死突变基因是目前未知的,其功能可能与心脏发育有关的基因。%Recent studies suggest that the basic molecular control mechanisms of early heart development are remarkably conserved in Drosophila, vertebrate and human being.Drosophila can be used as a prototype to explore the genetic basis of cardiogenesis in human being. Here, mutations of genes affecting heart development of Drosophila are produced by chemical mutagen methanesulfonicaeid ethyl. With staining of antibody expressed in heart precussor cells of Drosophila, 112 lethal lines were observed to show mutant phenotypes in pericardial cells. Of them, 32 lines differ in their mutant phenotypes from those of known genes. Analysis of cytogenetic mapping shows that they are located in 13 chromosomal regions without known heart-related genes, which implies that these loci contain genes probably involved in the heart development.

  15. Gibberellins regulate the stem elongation rate without affecting the mature plant height of a quick development mutant of winter wheat (Triticum aestivum L.).

    Science.gov (United States)

    Zhang, Ning; Xie, Yong-Dun; Guo, Hui-Jun; Zhao, Lin-Shu; Xiong, Hong-Chun; Gu, Jia-Yu; Li, Jun-Hui; Kong, Fu-Quan; Sui, Li; Zhao, Zi-Wei; Zhao, Shi-Rong; Liu, Lu-Xiang

    2016-10-01

    Gibberellin (GA) is essential for determining plant height. Alteration of GA content or GA signaling results in a dwarf or slender phenotype. Here, we characterized a novel wheat mutant, quick development (qd), in which GA regulates stem elongation but does not affect mature plant height. qd and wild-type plants did not exhibit phenotypic differences at the seedling stage. From jointing to heading stage, qd plants were taller than wild-type plants due to elongated cells. However, wild-type and qd plants were the same height at heading. Unlike wild-type plants, qd plants were sensitive to exogenous GA due to mutation of Rht-B1. With continuous GA stimulation, qd seedlings and adult plants were taller than wild-type. Thus, the GA content of qd plants might differ from that of wild-type during the growth process. Analysis of GA biosynthetic gene expression verified this hypothesis and showed that TaKAO, which is involved in catalyzing the early steps of GA biosynthesis, was differentially expressed in qd plants compared with wild-type. The bioactive GA associated gene TaGA20ox was downregulated in qd plants during the late growth stages. Measurements of endogenous GA content were consistent with the gene-expression analysis results. Consistent with the GA content variation, the first three basal internodes were longer and the last two internodes were shorter in qd than in wild-type plants. The qd mutant might be useful in dissecting the mechanism by which GA regulates stem-growing process, and it may be serve as a GA responsive semi-dwarf germplasm in breeding programs. PMID:27317908

  16. Expression of intracellular interferon-alpha confers antiviral properties in transfected bovine fetal fibroblasts and does not affect the full development of SCNT embryos.

    Directory of Open Access Journals (Sweden)

    Dawei Yu

    Full Text Available Foot-and-mouth disease, one of the most significant diseases of dairy herds, has substantial effects on farm economics, and currently, disease control measures are limited. In this study, we constructed a vector with a human interferon-α (hIFN-α (without secretory signal sequence gene cassette containing the immediate early promoter of human cytomegalovirus. Stably transfected bovine fetal fibroblasts were obtained by G418 selection, and hIFN-α transgenic embryos were produced by somatic cell nuclear transfer (SCNT. Forty-six transgenic embryos were transplanted into surrogate cows, and five cows (10.9% became pregnant. Two male cloned calves were born. Expression of hIFN-α was detected in transfected bovine fetal fibroblasts, transgenic SCNT embryos, and different tissues from a transgenic SCNT calf at two days old. In transfected bovine fetal fibroblasts, expression of intracellular IFN-α induced resistance to vesicular stomatitis virus infection, increased apoptosis, and induced the expression of double-stranded RNA-activated protein kinase gene (PKR and the 2'-5'-oligoadenylate synthetase gene (2'-5' OAS, which are IFN-inducible genes with antiviral activity. Analysis by qRT-PCR showed that the mRNA expression levels of PKR, 2'-5' OAS, and P53 were significantly increased in wild-type bovine fetal fibroblasts stimulated with extracellular recombinant human IFN-α-2b, showing that intracellular IFN-α induces biological functions similar to extracellular IFN-α. In conclusion, expression of intracellular hIFN-α conferred antiviral properties in transfected bovine fetal fibroblasts and did not significantly affect the full development of SCNT embryos. Thus, IFN-α transgenic technology may provide a revolutionary way to achieve elite breeding of livestock.

  17. Desenvolvimento radicular do algodoeiro em resposta à localização do fertilizante Cotton root development as affected by fertilizer placement

    Directory of Open Access Journals (Sweden)

    Fábio Suano de Souza

    2007-04-01

    Full Text Available A utilização de adubos pode-se tornar prejudicial caso o fertilizante não seja localizado adequadamente. No presente trabalho foram estudados o crescimento radicular do algodoeiro (Gossypium hirsutum, o crescimento inicial e a nutrição da planta, considerando o local de aplicação do fertilizante. O estudo foi realizado em vasos com parede de vidro. O fertilizante foi colocado a 5,0 cm abaixo e 0,0, 2,5, 5,0 e 10,0 cm ao lado das sementes. O crescimento radicular foi avaliado a cada três dias e, aos 21 dias após a emergência, as plantas foram coletadas, sendo avaliada a produção de matéria seca e a absorção de macronutrientes. A aplicação de fertilizante proporcionou crescimento inicial mais vigoroso do sistema radicular mesmo em solo previamente corrigido e adubado, o que é importante no estabelecimento da cultura. Somente houve bom crescimento inicial do sistema radicular e da parte aérea do algodoeiro quando o fertilizante foi aplicado de 5,0 a 10,0 cm ao lado e 5,0 cm abaixo das sementes.Unless fertilizer is properly placed in the soil it can be harmful. This experiment was conducted to study cotton (Gossypium hirsutum root growth and initial plant development and nutrition as affected by fertilizer placement. Cotton plants were grown in pots with a glass wall. The fertilizer was applied 5.0 cm under the seed row and 0, 2.5, 5.0 and 10.0 cm beside the seed row. Root growth was evaluated every 3 days, and 21 days after emergence the plants were harvested. Dry matter production and macronutrient absorption were evaluated. Even in previously limed and fertilized soil, localized fertilizer application reinforced the initial growth of cotton roots, which is very important for a good crop establishment in the field. Normal root growth and adequate initial plant development was only observed when the fertilizer was placed 5.0 cm below and from 5.0 to 10.0 cm distance from the seed row.

  18. The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.

    Directory of Open Access Journals (Sweden)

    Lisa Korostowski

    2012-09-01

    development and function. We also uncover a novel mechanism by which an antisense non-coding RNA affects transcription through regulating chromatin flexibility and access to enhancers.

  19. The affect of community dynamics and knowledge on the acceleration of technology development for the transition towards a hydrogen based transport system in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Van Giessel, J.F.; Ros, M.

    2003-03-15

    Due to the disadvantages (energy security, urban air pollution, the risk of climate change due to CO2 emission) of the current energy system, scientists and policymakers are searching for alternative energy sources to reduce the need for and use of fossil fuel and make the energy system more sustainable. Hydrogen is one of the proposed options. The transportation sector has a large contribution to climate change in terms of carbon dioxide emission. Hydrogen can be used as an alternative fuel to reduce the air pollution and CO2 emission in the transportation sector. In Europe many organisations and institutions are working together on the research and development of hydrogen as an alternative energy carrier for the transportation sector. The EC tries to reach the policy goal to substitute 2% of the fuel used in the transportation sector by hydrogen in the year 2015 and even 5% in the year 2020. In the EU, Germany is a frontrunner in the amount of hydrogen R and D projects. Many R and D projects in Germany are aimed at the transport sector. Most major car manufactures in Germany, especially DaimlerChrysler and BMW, invest large amounts of money in the R and D of hydrogen and fuel cell technologies. Besides spending of these organisations, the Federal German government and some state governments (Bundesstate) stimulate the development of hydrogen and fuel cell technologies since 1980. The growing awareness of both policy makers and major car manufactures in Germany to use hydrogen as an alternative fuel for the transportation sector makes it interesting to review this transition process in the transportation sector in Germany and see if this process can be accelerated. The innovation systems theory and the co-evolution of technology and community distinguish community dynamics and knowledge as important factors for describing technological change. In this research these factors will be used to determine the affect on the acceleration of technology development. The

  20. Investigation of environmental change pattern in Japan: A study on change detection of land cover in Tokyo districts using multi-dates LANDSAT CCT

    Science.gov (United States)

    Maruyasu, T.; Murai, S. (Principal Investigator)

    1976-01-01

    The author has identified the following significant results. The software program, which enables the geographically corrected LANDSAT digital data base, was developed. The data base could provide land use planners with land cover information and the environmental change pattern. Land cover was evaluated by the color representation for ratio of three primary components, water vegetation, and nonorganic matter. Software was also developed for the change detection within multidates LANDSAT MSS data.

  1. Clean coal technology deployment: From today into the next millennium

    Energy Technology Data Exchange (ETDEWEB)

    Papay, L.T.; Trocki, L.K.; McKinsey, R.R. [Bechtel Technology and Consulting, San Francisco, CA (United States)

    1997-12-31

    The Department of Energy`s clean coal technology (CCT) program succeeded in developing more efficient, cleaner, coal-fired electricity options. The Department and its private partners succeeded in the demonstration of CCT -- a major feat that required more than a decade of commitment between them. As with many large-scale capital developments and changes, the market can shift dramatically over the course of the development process. The CCT program was undertaken in an era of unstable oil and gas prices, concern over acid rain, and guaranteed markets for power suppliers. Regulations, fuel prices, emergency of competing technologies, and institutional factors are all affecting the outlook for CCT deployment. The authors identify the major barriers to CCT deployment and then introduce some possible means to surmount the barriers.

  2. Perspectives of healthcare providers and HIV-affected individuals and couples during the development of a Safer Conception Counseling Toolkit in Kenya: stigma, fears, and recommendations for the delivery of services.

    Science.gov (United States)

    Mmeje, Okeoma; Njoroge, Betty; Akama, Eliud; Leddy, Anna; Breitnauer, Brooke; Darbes, Lynae; Brown, Joelle

    2016-06-01

    Reproduction is important to many HIV-affected individuals and couples and healthcare providers (HCPs) are responsible for providing resources to help them safely conceive while minimizing the risk of sexual and perinatal HIV transmission. In order to fulfill their reproductive goals, HIV-affected individuals and their partners need access to information regarding safer methods of conception. The objective of this qualitative study was to develop a Safer Conception Counseling Toolkit that can be used to train HCPs and counsel HIV-affected individuals and couples in HIV care and treatment clinics in Kenya. We conducted a two-phased qualitative study among HCPs and HIV-affected individuals and couples from eight HIV care and treatment sites in Kisumu, Kenya. We conducted in-depth interviews (IDIs) and focus group discussions (FGDs) to assess the perspectives of HCPs and HIV-affected individuals and couples in order to develop and refine the content of the Toolkit. Subsequently, IDIs were conducted among HCPs who were trained using the Toolkit and FGDs among HIV-affected individuals and couples who were counseled with the Toolkit. HIV-related stigma, fears, and recommendations for delivery of safer conception counseling were assessed during the discussions. One hundred and six individuals participated in FGDs and IDIs; 29 HCPs, 49 HIV-affected women and men, and 14 HIV-serodiscordant couples. Participants indicated that a safer conception counseling and training program for HCPs is needed and that routine provision of safer conception counseling may promote maternal and child health by enhancing reproductive autonomy among HIV-affected couples. They also reported that the Toolkit may help dispel the stigma and fears associated with reproduction in HIV-affected couples, while supporting them in achieving their reproductive goals. Additional research is needed to evaluate the Safer Conception Toolkit in order to support its implementation and use in HIV care and

  3. Demographic and socio-economic factors affecting the physical development, haemoglobin and parasitic infection status of schoolchildren in Sanliurfa province, Turkey.

    Science.gov (United States)

    Ulukanligil, M; Seyrek, A

    2004-03-01

    A cross-sectional population-based survey was undertaken to evaluate the relationship between nutritional status and parasitic infections of schoolchildren and demographic, socio-economic factors in Sanliurfa province, southern Turkey. Nine hundred and eight schoolchildren took part in the survey: 57.2% boys and 42.7% girls. The children's mean z scores were as follows: height for age-0.8 (+/-1.0) and weight for age-1.0 (+/-0.9). The mean haemoglobin concentration was 123 g/l (+/-2.1) and the prevalence of parasitic infections was 55.1%. In total, 50.2% of children were hungry when they arrived at school and 13.4% worked after school. Over 70% (70.4%) of mothers and 18.1% of fathers were illiterate, 16.1% of fathers were unemployed and 46.3% of fathers were engaged in low-income labour. The mean number of children in each family was 5.4 (+/-2.5), and the mean number of children from each family who attended school was 2.1 (+/-1.1). The school-attendance ratio was 0.4 (+/-1.0). Data indicated that older children had significantly lower mean z scores of height (P school had significantly lower mean haemoglobin concentrations than those who had eaten (P : 0.04). Multiple regression analyses indicated that mean z scores of height for age were significantly related to maternal (multiple R = 0.183; P school health programmes may improve the nutritional and health status of schoolchildren. The participation of the local community, which such a programme would entail, may help to increase maternal awareness regarding the feeding of their children before sending them to school. School health programmes may also motivate parents to send their daughters to school, thus increasing maternal literacy in the future. In turn, better levels of maternal literacy will positively affect the socio-economic development of society. PMID:15037047

  4. Developing an environmentally appropriate, socially acceptable and gender-sensitive technology for safe-water supply to households in arsenic affected areas in rural Bangladesh

    NARCIS (Netherlands)

    Amin, N.

    2010-01-01

    To confront the arsenic crisis in Bangladesh, several options for a safe water supply in the rural As-affected areas are available. Most of these options have shown a minimum scope to mitigate arsenic-related risks because of their poor performance and non-acceptability by the rural households. In t

  5. Archive of single-beam bathymetry data collected during USGS cruise 07CCT01 nearshore of Fort Massachusetts and within Camille Cut, West and East Ship Islands, Gulf Islands National Seashore, Mississippi, July 2007

    Science.gov (United States)

    DeWitt, Nancy T.; Flocks, James G.; Reynolds, B.J.; Hansen, Mark

    2012-01-01

    identifier to each cruise or field activity. For example, 07CCT01 tells us the data were collected in 2007 for the Coastal Change and Transport (CCT) study and the data were collected during the first (01) field activity for that project in that calendar year. Refer to http://walrus.wr.usgs.gov/infobank/programs/html/definition/activity.html for a detailed description of the method used to assign the field activity ID. Data were collected using a 26-foot (ft) Glacier Bay catamaran. The single-beam transducers were sled mounted on a rail attached between the catamaran hulls. Navigation was acquired using HYPACK, Inc., Hypack version 4.3a.7.1 and differentially corrected using land-based GPS stations. See the digital FACS equipment log for details about the acquisition equipment used. Raw datasets were stored digitally and processed systematically using NovAtel's Waypoint GrafNav version 7.6, SANDS version 3.7, and ESRI ArcGIS version 9.3.1. For more information on processing refer to the Equipment and Processing page.

  6. Clean coal technology III (CCT III): 10 MW demonstration of gas suspension absorption. Technical progress report, October 1, 1990--December 31, 1990

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-31

    This project will be the first North American demonstration of the Gas Suspension Absorption (GSA) System in its application for flue gas desulfurization. The purpose of this project is to demonstrate the high sulfur dioxide (SO{sub 2}) removal efficiency as well as the cost effectiveness of the GSA system. GSA is a novel concept for flue gas desulfurization developed by F.L. Smidth miljo (FLS miljo). The GSA system is distinguished in the European market by its low capital cost, high SO{sub 2} removal efficiency and low operating cost. The specific technical objectives of the GSA demonstration project are to: effectively demonstrate SO{sub 2} removal in excess of 90% using high sulfur US coal. Optimize recycle and design parameters to increase efficiencies of lime reagent utilization and SO{sub 2} removal. Compare removal efficiency and cost with existing Spray Dryer/Electrostatic Precipitator technology.

  7. The role of motivation and metacognition on the development of cognitive and affective responses in physical education les-sons: A self-determination approach

    OpenAIRE

    Yannis Karagiannidis; Vassilis Barkoukis; Vassilis Gourgoulis; George Kosta; Panagiotis Antoniou

    2015-01-01

    The study investigated the role of motivation and metacognition in the formation of cognitive and affective outcomes from participation in physical education lessons within the framework of self-determination theory. A sample of 630 adolescents (M age = 14.06, SD = .29) participated in the study. Participants completed questionnaires including measures of perceived autonomy support in PE, autonomous motivation in PE, metacognitive processes in PE, enjoyment, boredom in PE and intention for le...

  8. The Developing, Field Testing, and Initial Norming of a Secondary/Adult Level Reading Attitude Measure That Is Behaviorally Oriented and Based on Krathwohl's Taxonomy of the Affective Domain.

    Science.gov (United States)

    Mikulecky, Larry Joseph

    This dissertation reports the development of the Mikulecky Behavioral Reading Attitude Measure (MBRAM), designed to be appropriate for use with mature readers. Items were written with direct reference to the Hovland-Rosenberg tricomponent model of attitude and to the stages of Krathwohl's Taxonomy of the Affective Domain. The MBRAM was…

  9. Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.

    Directory of Open Access Journals (Sweden)

    Satya P Panda

    Full Text Available NADPH-cytochrome P450 oxidoreductase (POR is the primary electron donor for cytochromes P450, dehydrocholesterol reductase, heme oxygenase, and squalene monooxygenase. Human patients with specific mutations in POR exhibit severe developmental malformations including disordered steroidogenesis, sexual ambiguities and various bone defects, similar to those seen in patients with Antley-Bixler syndrome (ABS. To probe the role of POR during bone development, we generated a conditional knockout mouse (CKO by cross breeding Por (lox/lox and Dermo1 Cre mice. CKO mice were smaller than their littermate controls and exhibited significant craniofacial and long bone abnormalities. Differential staining of the CKO mice skull bases shows premature fusion of the sphenooccipital and basioccipital-exoccipital synchondroses. Class III malocclusion was noted in adult knockout mice with an unusual overgrowth of the lower incisors. Shorter long bones were observed along with a reduction in the bone volume fraction, measured by microCT, in the Por-deleted mice compared to age- and sex-matched littermate controls. Concerted up- or down-regulation of proteins in the FGF signaling pathway observed by immunohistochemistry in the tibia samples of CKO mice compared to wild type controls shows a decrease in the FGF signaling pathway. To our knowledge, this is the first report of a mouse model that recapitulates both skull and long bone defects upon Por deletion, offering an approach to study the sequelae of POR mutations. This unique model demonstrates that P450 metabolism in bone itself is potentially important for proper bone development, and that an apparent link exists between the POR and FGF signaling pathways, begging the question of how an oxidation-reduction flavoprotein affects developmental and cellular signaling processes.

  10. Experiencing affective interactive art

    NARCIS (Netherlands)

    Bialoskorski, Leticia S.S.; Westerink, Joyce H.D.M.; Broek, van den Egon L.

    2010-01-01

    The progress in the field of affective computing enables the realization of affective art. This paper describes the affective interactive art system Mood Swings, which interprets and visualizes affect expressed by a person. Mood Swings is founded on the integration of a framework for affective move

  11. Impact of Wheat Bran Hydration Properties As Affected by Toasting and Degree of Milling on Optimal Dough Development in Bread Making.

    Science.gov (United States)

    Jacobs, Pieter J; Bogaerts, Silke; Hemdane, Sami; Delcour, Jan A; Courtin, Christophe M

    2016-05-11

    The impact of the hydration capacity and hydration rate of wheat bran on optimal bread dough development and loaf volume was investigated using coarse bran, both native as well as after toasting, milling, presoaking, and combinations of the latter. It was found that toasting reduces bran's hydration rate, which, during mixing, results in a temporary excess of water in which dough development takes place inefficiently and hence requires additional time. This mechanism was further substantiated by the observation that delayed dough development can be counteracted by the presoaking of bran. Milling of bran increases its hydration rate and results in faster optimal dough development. Presoaking of nonmilled bran, however, did not result in faster dough development. Smaller bran particles do lead to faster dough development, probably due to increased proper contacts between flour particles. Optimal loaf volumes did not change upon milling and toasting. PMID:27092966

  12. CLAVATA3 is a specific regulator of shoot and floral meristem development affecting the same processes as CLAVATA1

    OpenAIRE

    Clark, Steven M.; Running, Mark P; Meyerowitz, Elliot M.

    1995-01-01

    We have previously described the phenotype of Arabidopsis thaliana plants with mutations at the CLAVATA1 (CLV1) locus (Clark, S. E., Running, M. P. and Meyerowitz, E. M. (1993) Development 119, 397-418). Our investigations demonstrated that clv1 plants develop enlarged vegetative and inflorescence apical meristems, and enlarged and indeterminate floral meristems. Here, we present an analysis of mutations at a separate locus, CLAVATA3(CLV3), that disrupt meristem development in a manner similar ...

  13. The role of motivation and metacognition on the development of cognitive and affective responses in physical education les-sons: A self-determination approach

    Directory of Open Access Journals (Sweden)

    Yannis Karagiannidis

    2015-05-01

    Full Text Available The study investigated the role of motivation and metacognition in the formation of cognitive and affective outcomes from participation in physical education lessons within the framework of self-determination theory. A sample of 630 adolescents (M age = 14.06, SD = .29 participated in the study. Participants completed questionnaires including measures of perceived autonomy support in PE, autonomous motivation in PE, metacognitive processes in PE, enjoyment, boredom in PE and intention for leisure-time physical activity. Multiple linear regression analyses revealed that perceptions of autonomy supportive motivational climate significantly predicted enjoyment, boredom and intentions towards leisure-time physical activity. In addition autonomous motivation and metacognition significantly predicted enjoyment, boredom and intentions, whereas controlling motivation was a significant predictor of boredom. Multiple mediation modeling indicated that perceptions of autonomy supporting climate on these responses was mediated mainly by autonomous motivation and metacognition. The findings of the present study provide valuable information on the mediating role of autonomous motivation and metacognition on the effects of autonomy supportive motivational climate on students’ cognitive and affective responses during physical education lessons.

  14. Visual affect recognition

    CERN Document Server

    Stathopoulou, I-O

    2010-01-01

    It is generally known that human faces, as well as body motions and gestures, provide a wealth of information about a person, such as age, race, sex and emotional state. This monograph primarily studies the perception of facial expression of emotion, and secondarily of motion and gestures, with the purpose of developing a fully automated visual affect recognition system for use in modes of human/computer interaction. The book begins with a survey of the literature on emotion perception, followed by a description of empirical studies conducted with human participants and the construction of a '

  15. Neurotransmitters affecting time perception

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND:It has been demonstrated that dopamine and acetylcholine are the main neurotransmitters that affect time perception,which is also affected by other neurotransmitters.OBJECTIVE:To summarize how the neurotransmitter affect the time perception,and put forward the perspectives for further study on time perception.RETRIEVE STRATEGY:An online search for related literatures published in English was conducted in Elsevier SDOL(ScienceDirect Online)database from May 1990 to March 2007 using key words of "timing neurotransmitter".Totally 69 literatures were collected,and they were primarily checked.Inclusive criteria:Reviews and experimental studies;correlative studies of timing neurotransmitter.Exclusive criteria:Repeated studies.LITERATURE EVALUATION:The literatures were mainly sourced from Cognitive Brain Research and Neuroscience,and they were analyzed according to the inclusive criteria.Nineteen of them were involved,and all were experimental studies and reviews.DATA SYNTHESIS:The studies on time perception are developed mainly concentrating on dopamine and acetylcholine.Dopamine D2 receptors mainly affect the speed of internal clock.Dopamine receptors play an important role in both timing excitation and inhibition,which suggests the bi-directional regulation of dopamine.Injection of dopamine agonist can affect the attention to timing information.Injection of BW813U(antagonist of acetylcholine) can induce memory disorder,which indicates the effect of acetylcholine on timing memory,and further study shows that it is the effect of acetylcholine in precentral medial area.In a word,the study on the neurotransmitters affecting time perception is still at the primary stage.CONCLUSION:Dopamine and acetylcholine are the neurotransmitters known to be related to time perception.Dopamine in the basal ganglia is related to internal-clock in the range of seconds and minutes;Acetylcholine in prefrontal cortex is related to the mechanisms of temporal memory and attention

  16. Identification and characterisation of factors affecting losses in the large-scale, non-ventilated bulk storage of wood chips and development of best storage practices

    Energy Technology Data Exchange (ETDEWEB)

    Garstang, J.; Weekes, A.; Poulter, R.; Bartlett, D.

    2002-07-01

    The report describes the findings of a study to determine the factors affecting the commercial storage of wood chips for biomass power generation in the UK. The UK's first such plant in North Yorkshire uses a mixture of forestry residues and short rotation coppice (SRC) willow, where problems with the stored fuel highlighted the need to determine best storage practices. Two wood chip piles were built (one with willow chip and the other with wood chips from board leaf forestry residues) and monitored (moisture, temperature, chemical composition, spore numbers and species, heat and air flows, bulk density, etc). Local weather data was also obtained. Recommendations for future storage practices are made.

  17. Test-Driven Development in Clojure : An analysis of how differences between Clojure and Java affects unit testing and design patterns

    OpenAIRE

    Nilsson, Niclas

    2015-01-01

    Agile methods and Test-Driven Development are well established methodologies within the software development industry. As a large part of today’s software development is done in Object-Oriented languages like Java it’s only natural that agile best practices have evolved to fit into the Object-Oriented paradigm. Clojure is a relatively young programming language that greatly differs from Object-Oriented languages and it’s thus not certain that these best practices can be directly applicable in...

  18. Risk factors affecting child cognitive development: a summary of nutrition, environment, and maternal-child interaction indicators for sub-Saharan Africa.

    Science.gov (United States)

    Ford, N D; Stein, A D

    2016-04-01

    An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper is to identify scope for improvement at the country level in three domains--nutrition, environment, and mother-child interactions. We used nationally representative data from large-scale surveys, data repositories and country reports from 2000 to 2014. Overall, there was heterogeneity in performance across domains, suggesting that each country faces distinct challenges in addressing risk factors for poor child development. Data were lacking for many indicators, especially in the mother-child interaction domain. There is a clear need to improve routine collection of high-quality, country-level indicators relevant to child development to assess risk and track progress. PMID:26358240

  19. CCT-konferenssin markkinointiviestintäsuunnitelma

    OpenAIRE

    Tyynysniemi, Sara

    2014-01-01

    Opinnäytetyön tavoitteena on tuottaa Aalto-yliopiston kauppakorkeakoulussa kesällä 2014 järjestettävälle markkinoinnin alan konferenssille markkinointiviestintäsuunnitelma, jonka markkinointiviestintätoimenpiteet ovat digitaalisesti toteutettavia. Kesäkuussa järjestettävä konferenssi keskittyy kuluttajakäyttäytymisteoriaan (Consumer Culture Theory). Markkinointiviestintäsuunnitelma pohjautuu pitkälti tekijän omiin havaintoihin, keskusteluihin ja kokemuksiin ajalta, jolloin hän työskentel...

  20. 13CCT04_IFB_tracklines.shp

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — In August of 2013, the U.S. Geological Survey (USGS) conducted geophysical surveys offshore of Petit Bois Island, Mississippi. These efforts are a continued part of...

  1. β-Carotene and its cleavage enzyme β-carotene-15,15′-oxygenase (CMOI) affect retinoid metabolism in developing tissues

    OpenAIRE

    Kim, Youn-Kyung; Wassef, Lesley; Chung, Stacey; Jiang, Hongfeng; Wyss, Adrian; Blaner, William S.; Quadro, Loredana

    2011-01-01

    The mammalian embryo relies on maternal circulating retinoids (vitamin A derivatives) for development. β-Carotene is the major human dietary provitamin A. β-Carotene-15,15′-oxygenase (CMOI) has been proposed as the main enzyme generating retinoid from β-carotene in vivo. CMOI is expressed in embryonic tissues, suggesting that β-carotene provides retinoids locally during development. We performed loss of CMOI function studies in mice lacking retinol-binding protein (RBP), an established model ...

  2. 协同创新知识属性多维分析与CCT治理模式研究%Multi-dimensional Analysis of Knowledge Attributes and CCT Governance-model in Collaborative Innovation

    Institute of Scientific and Technical Information of China (English)

    邢青松; 上官登伟; 梁学栋; 邓富民; 王永锋

    2016-01-01

    日趋强化且严格的产权与专利保护对协同创新异质主体知识共享产生了重要影响,基于社会属性视角,从法律、创新、外部和商品4个方面对专利和产权保护下异质主体知识属性进行了分析,揭示了4种属性对协同创新知识共享的影响机理。在此基础上,构建了基于“契约-章程-信任(contract‐constitute‐trust ,CCT)”的协同创新知识共享治理模式,并分析了该模式在共享高度、广度和深度3方面的正向作用,以期抑制知识外部属性和法律属性的不利影响,改善知识共享环境,提升异质主体间的信任度和知识共享水平,最大程度地发挥知识创新价值溢出的商品属性。%The property and patent protected that are increasingly strengthened and rigorous have an important impact for heterogeneous body of collaborative innovation on knowledge sharing .Based on the perspective of social attributes of knowledge ,analyzing attributes of knowledge from those of law ,innovation ,external and commodity under property and patent protection ,and characterizing its characteristics .Then ,revealing the impact mechanism that such attributes to the collaborative innovation knowledge sharing .On this basis ,building the knowledge sharing governance model based on contract ,constitution and trust (CCT ) in collaborative innovation ,and analyzing the governance model positive role in height ,breadth and depth of knowledge sharing to suppress the adverse effects of external attributes and legal attributes . And improving knowledge sharing environment and enhancing the level of trust and knowledge sharing among heterogene‐ous body by this ,thereby maximizing the commodity attributes of overflow innovation value of knowledge .

  3. Overexpression of PhEXPA1 increases cell size, modifies cell wall polymer composition and affects the timing of axillary meristem development in Petunia hybrida.

    Science.gov (United States)

    Zenoni, Sara; Fasoli, Marianna; Tornielli, Giovanni Battista; Dal Santo, Silvia; Sanson, Andrea; de Groot, Peter; Sordo, Sara; Citterio, Sandra; Monti, Francesca; Pezzotti, Mario

    2011-08-01

    • Expansins are cell wall proteins required for cell enlargement and cell wall loosening during many developmental processes. The involvement of the Petunia hybrida expansin A1 (PhEXPA1) gene in cell expansion, the control of organ size and cell wall polysaccharide composition was investigated by overexpressing PhEXPA1 in petunia plants. • PhEXPA1 promoter activity was evaluated using a promoter-GUS assay and the protein's subcellular localization was established by expressing a PhEXPA1-GFP fusion protein. PhEXPA1 was overexpressed in transgenic plants using the cauliflower mosaic virus (CaMV) 35S promoter. Fourier transform infrared (FTIR) and chemical analysis were used for the quantitative analysis of cell wall polymers. • The GUS and GFP assays demonstrated that PhEXPA1 is present in the cell walls of expanding tissues. The constitutive overexpression of PhEXPA1 significantly affected expansin activity and organ size, leading to changes in the architecture of petunia plants by initiating premature axillary meristem outgrowth. Moreover, a significant change in cell wall polymer composition in the petal limbs of transgenic plants was observed. • These results support a role for expansins in the determination of organ shape, in lateral branching, and in the variation of cell wall polymer composition, probably reflecting a complex role in cell wall metabolism. PMID:21534969

  4. Development of screening technique for the plutonium burden determination of the Ukrainian population living in the territories affected by the Chernobyl accident

    International Nuclear Information System (INIS)

    Alpha emitting transuranic radionuclides comprised a significant part of the radioactive release of the Chernobyl accident. In the first years after the accident the highest priority was given to mapping the density of plutonium fallout of affected territories. The assignment of radiobiological status to localities in Ukraine has been based on measured values of soil contamination. With regard to plutonium the dose estimates are calculated indirectly and not based on human measurements (autopsy, biopsy, urine etc.). Direct data on actual levels of Pu in the human would allow correct substantiation of dosimetric models for internal irradiation. So that radiological status could be assigned on a more accurate basis. It is proposed a new instrumental method for measurement of ultra-low levels of plutonium in autopsy and urine. The method presumes first a standard radiochemical extraction of plutonium from a sample. Then a stainless steel disc with plated out plutonium is measured by solid-state nuclear track (SSNT) alpha spectroscopy. As a result the best lower limit of detection is achieved. In its turn it makes feasible detection of low levels of plutonium contents in the population

  5. THE ROLE OF MEDIA IN SCIENCE AND TECHNOLOGY EDUCATION, DEVELOPMENT AND REHABILITATION OF WOMEN AFFECTED BY THE 2004 TSUNAMI IN THE OF THE STATE OF TAMILNADU

    Directory of Open Access Journals (Sweden)

    P. Sri Jothi

    2011-01-01

    Full Text Available The great Sumatra earthquake of 26 December 2004 generated a destructive tsunami which devastated coastal communities bordering the Indian Ocean, killing thousands of people in Indonesia, Sri Lanka, India, Thailand, Somalia, Myanmar, the Maldives, Malaysia, Tanzania, Seychelles, Bangladesh, South Africa, Yemen and Kenya. It was one of the deadliest natural disasters in modern history. In India, the death toll and damages were severe, particularly along the southern and eastern coastal regions. Subsequently, central and state government authorities in the state of Tamilnadu - one of the most severely stricken regions - took immediate measures for tsunami preparedness and rehabilitation. The media played a major role in this effort by communicating to the public information related to the science and technology facts of tsunami hazards and to ways of mitigating their impact with better understanding and preparedness. Through its superior ability to communicate effectively information, the media became the role model in helping people make decisions for their own welfare. The present study was undertaken for the purpose of determining the media’s role in the post-rehabilitation efforts and particularly in improving the status of affected women of the north Chennai region, who were forced to migrate from Ernavour and Ennore, in Chennai district, in the India state of Tamilnadu, by providing them science and technology communication.

  6. Going Deep into Mechanisms for Moral Reasoning Growth: How Deep Learning Approaches Affect Moral Reasoning Development for First-Year Students

    Science.gov (United States)

    Mayhew, Matthew J.; Seifert, Tricia A.; Pascarella, Ernest T.; Nelson Laird, Thomas F.; Blaich, Charles F.

    2012-01-01

    The purpose of this paper was to determine the effects of deep approaches to learning on the moral reasoning development of 1,457 first-year students across 19 institutions. Results showed a modest positive relationship between our measures of deep approaches to learning and moral reasoning at the end of the first year of college even after…

  7. Normal female carrier and affected male half-sibs with t(X;5)(q13;p15). Location of a gene determining male genital development.

    Science.gov (United States)

    Callen, D F; Sutherland, G R

    1986-07-01

    A unique family in which half-brothers have a maternally derived t(X;5)(q13;p15) and similar genital malformations is described. This family provides evidence for a gene required for male genital development located at Xq13. PMID:3757297

  8. Using Corporate Tools for Organizational Development to Affect Cultural and Structural Change in the Academy: Gallup Impact Planning at the University of Nebraska-Lincoln

    Science.gov (United States)

    Latta, Gail F.

    2006-01-01

    External pressures have transformed academic life, shattering the roles and relationships that created a sense of community. Increasingly the challenges of fostering an engaged workforce in these institutions mirror the corporate world. Leaders at UNL have adapted Gallup's organizational development strategy to improve faculty engagement and…

  9. Genes affecting novel seed constituents in Limnanthes alba Benth: transcriptome analysis of developing embryos and a new genetic map of meadowfoam

    Directory of Open Access Journals (Sweden)

    Mary B. Slabaugh

    2015-05-01

    Full Text Available The seed oil of meadowfoam, a new crop in the Limnanthaceae family, is highly enriched in very long chain fatty acids that are desaturated at the Δ5 position. The unusual oil is desirable for cosmetics and innovative industrial applications and the seed meal remaining after oil extraction contains glucolimnanthin, a methoxylated benzylglucosinolate whose degradation products are herbicidal and anti-microbial. Here we describe EST analysis of the developing seed transcriptome that identified major genes involved in biosynthesis and assembly of the seed oil and in glucosinolate metabolic pathways. mRNAs encoding acyl-CoA Δ5 desaturase were notably abundant. The library was searched for simple sequence repeats (SSRs and single nucleotide polymorphisms (SNPs. Fifty-four new SSR markers and eight candidate gene markers were developed and combined with previously developed SSRs to construct a new genetic map for Limnanthes alba. Mapped genes in the lipid biosynthetic pathway encode 3-ketoacyl-CoA synthase (KCS, Δ5 desaturase (Δ5DS, lysophosphatidylacyl-acyl transferase (LPAT, and acyl-CoA diacylglycerol acyl transferase (DGAT. Mapped genes in glucosinolate biosynthetic and degradation pathways encode CYP79A, myrosinase (TGG, and epithiospecifier modifier protein (ESM. The resources developed in this study will further the domestication and improvement of meadowfoam as an oilseed crop.

  10. Development of a Family-Based Program to Reduce Risk and Promote Resilience among Families Affected by Maternal Depression: Theoretical Basis and Program Description

    Science.gov (United States)

    Riley, Anne W.; Valdez, Carmen R.; Barrueco, Sandra; Mills, Carrie; Beardslee, William; Sandler, Irwin; Rawal, Purva

    2008-01-01

    Depression is a family matter. It not only diminishes the quality-of-life of the depressed person, but also strains the resources of the family unit and increases the children's risk of developing significant problems that start early and persist into adulthood. Although treatment of a parent's depression is critical, many families also need…

  11. Control of the development of residual stresses and heat affected zone (HAZ) microstructure during welding of low alloy steels and influence on stress relieve cracking

    International Nuclear Information System (INIS)

    Creep resistant 1 Cr 0.5 Mo steels are frequently used as steam pipes at operating temperature of 450 degree C to 500 degrees C. Welded joints have been post weld heat treated (PWHT). The results show: - In fully refined microstructures close to the fusion boundary of the weldments a reduction of the grain size by a factor of 3-4 was measured. The impact transition temperature was up to 27 degree C lower for test series notched in the refined HAZ (Heat Affected Zone) than in the coarse grained HAZ of the as welded condition. The overlay heat treatments were not observed to significantly influence the hardness and the room temperature tensile properties of the weldments. - The influence of refinement on impact transition temperature (ITT) and upper shelf energy was beneficial. In the coarse grained HAZ, for which the ITT was significantly higher than for weld metal and base metal, the refinement resulted in a 30 degrees C lower value of the ITT. The influence of PWHT on impact properties was also studied. The PWHT raised the upper shelf energy greatly. The effect on the ITT was smaller than that of refinement. - For cross welds in the as-welded (AW) condition refinement improved the creep properties. After PWHT the creep ductility was significantly increased at the same as a considerable reduction of life was observed. At lower stresses the effects of refinement and especially PWHT were less pronounced. Beneficial influence of refinement in inhibiting the formation of creep cavitation was apparent regardless stress level in both AW and PWHT conditions. (K.A.E)

  12. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease.

    Science.gov (United States)

    Zizioli, Daniela; Tiso, Natascia; Guglielmi, Adele; Saraceno, Claudia; Busolin, Giorgia; Giuliani, Roberta; Khatri, Deepak; Monti, Eugenio; Borsani, Giuseppe; Argenton, Francesco; Finazzi, Dario

    2016-01-01

    Pantothenate Kinase Associated Neurodegeneration (PKAN) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (PANK2), encoding an essential enzyme for Coenzyme A (CoA) biosynthesis. The molecular connection between defects in this enzyme and the neurodegenerative phenotype observed in PKAN patients is still poorly understood. We exploited the zebrafish model to study the role played by the pank2 gene during embryonic development and get new insight into PKAN pathogenesis. The zebrafish orthologue of hPANK2 lies on chromosome 13, is a maternal gene expressed in all development stages and, in adult animals, is highly abundant in CNS, dorsal aorta and caudal vein. The injection of a splice-inhibiting morpholino induced a clear phenotype with perturbed brain morphology and hydrocephalus; edema was present in the heart region and caudal plexus, where hemorrhages with reduction of blood circulation velocity were detected. We characterized the CNS phenotype by studying the expression pattern of wnt1 and neurog1 neural markers and by use of the Tg(neurod:EGFP/sox10:dsRed) transgenic line. The results evidenced that downregulation of pank2 severely impairs neuronal development, particularly in the anterior part of CNS (telencephalon). Whole-mount in situ hybridization analysis of the endothelial markers cadherin-5 and fli1a, and use of Tg(fli1a:EGFP/gata1a:dsRed) transgenic line, confirmed the essential role of pank2 in the formation of the vascular system. The specificity of the morpholino-induced phenotype was proved by the restoration of a normal development in a high percentage of embryos co-injected with pank2 mRNA. Also, addition of pantethine or CoA, but not of vitamin B5, to pank2 morpholino-injected embryos rescued the phenotype with high efficiency. The zebrafish model indicates the relevance of pank2 activity and CoA homeostasis for normal neuronal development and functioning and provides evidence of an unsuspected role for this

  13. Affective Computing and Intelligent Interaction

    CERN Document Server

    2012-01-01

    2012 International Conference on Affective Computing and Intelligent Interaction (ICACII 2012) was the most comprehensive conference focused on the various aspects of advances in Affective Computing and Intelligent Interaction. The conference provided a rare opportunity to bring together worldwide academic researchers and practitioners for exchanging the latest developments and applications in this field such as Intelligent Computing, Affective Computing, Machine Learning, Business Intelligence and HCI.   This volume is a collection of 119 papers selected from 410 submissions from universities and industries all over the world, based on their quality and relevancy to the conference. All of the papers have been peer-reviewed by selected experts.  

  14. Rewards Affecting the Organizational Concerns

    OpenAIRE

    Doina I. POPESCU

    2011-01-01

    To obtain and maintain a high-performing workforce, an enterprise must develop a well-conceived compensation program. In addition to a salary, employees may be rewarded with benefit plans, bonuses, perquisites, stock options, and other long-term incentives. The main purpose of this article is to study how rewards affect employee perceptions, attitudes, and behavior in a variety of ways. Also, the purpose of this article is to analyze how organizational efficiency and effectiveness are affecte...

  15. Colonial Legacy in the Great Lakes Region. Has British and Belgian colonialism affected economic development differently in Burindi, Democratic Republic of Congo, Kenya, Rwanda, Tanzania and Uganda?

    OpenAIRE

    Hildigunnur Engilbertsdóttir 1983

    2011-01-01

    The effects of Belgian and British colonization strategies on the subsequent post-independent economic growth in colonies in the Great Lakes region are studied with a comparative analysis of certain key economic and socio-economic indicators. Different explanations of cross-country disparities in post-colonial development are examined with a focus on the impact of institutions on economic growth. The choice of countries was based on the fact that they share certain characteristics, such as: a...

  16. Identification and study of the relationship between factors and dimensions affecting the security of developed information systems using service-oriented architecture

    OpenAIRE

    Mandana izadi; Mohammad reza taghva

    2014-01-01

    Certain advantages of service-oriented architecture have led to the spread of this type of architecture around the world. However, some special features of this type of architecture have led to more compromise between the security in the information system and other information systems. The purpose of this paper is to identify and examine the impact of factors and dimensions of the information security system that has developed by using service-oriented architecture. In this study, the explor...

  17. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

    OpenAIRE

    Zizioli, Daniela; Tiso, Natascia; Guglielmi, Adele; Saraceno, Claudia; Busolin, Giorgia; Giuliani, Roberta; Khatri, Deepak; Monti, Eugenio; Borsani, Giuseppe; Argenton, Francesco; Finazzi, Dario

    2016-01-01

    Pantothenate Kinase Associated Neurodegeneration (PKAN) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (PANK2), encoding an essential enzyme for Coenzyme A (CoA) biosynthesis. The molecular connection between defects in this enzyme and the neurodegenerative phenotype observed in PKAN patients is still poorly understood. We exploited the zebrafish model to study the role played by the pank2 gene during embryonic development and get new insight into PKAN pat...

  18. Development of a Surgical Site Infection (SSI) Surveillance System, Calculation of SSI Rates and Specification of Important Factors Affecting SSI in a Digestive Organ Surgical Department

    OpenAIRE

    Kimura, Koji; Sawa, Akihiro; Akagi, Shinji; Kihira, Kenji

    2007-01-01

    We have developed an original system to conduct surgical site infection (SSI) surveillance. This system accumulates SSI surveillance information based on the National N osocomial Infections Surveillance (NNIS) System and the Japanese Nosocomial Infections Surveillance (JNIS) System. The features of this system are as follows: easy input of data, high generality, data accuracy, SSI rate by operative procedure and risk index category (RIC) can be promptly calculated and compared with the curren...

  19. Internal Communication During the Budgeting Process : -A case study of developing a model for factors affecting internal communications during the budgeting process

    OpenAIRE

    Kamali, Mikael; Chen, Xiaohang

    2014-01-01

    The budget is used in many organizations to estimate and control costs. The budgeting process requires extensive knowledge and information exchange between the budget setters in the organization. It is therefore critical for budget setters, often finance and line managers, to communicate and exchange knowledge to reach a budget for the upcoming period.   The aim of this thesis is to highlight both budgeting and internal communication findings from past research, and develop a model for how in...

  20. Exposure to coal combustion residues during metamorphosis elevates corticosterone content and adversely affects oral morphology, growth, and development in Rana sphenocephala

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, J.D.; Peterson, V.A.; Mendonca, M.T. [Auburn University, Auburn, AL (USA). Dept. of Biological Science

    2009-01-15

    Coal combustion residues (CCRs) are documented to negatively impact oral morphology, growth, and development in larval amphibians. It is currently unclear what physiological mechanisms may mediate these effects. Corticosterone, a glucocorticoid hormone, is a likely mediator because when administered exogenously it, like CCRs, also negatively influences oral morphology, growth, and development in larval amphibians. In an attempt to identify if corticosterone mediates these effects, we raised larval Southern Leopard Frogs, Rana sphenocephala, on either sand or CCR substrate and documented effects of sediment type on whole body corticosterone, oral morphology, and time to and mass at key metamorphic stages. Coal combustion residue treated tadpoles contained significantly more corticosterone than controls throughout metamorphosis. However, significantly more oral abnormalities occurred early in metamorphosis when differences in corticosterone levels between treatments were minimal. Overall, CCR-treated tadpoles took significantly more time to transition between key stages and gained less mass between stages than controls, but these differences between treatments decreased during later stages when corticosterone differences between treatments were greatest. Our results suggest endogenous increase in corticosterone content and its influence on oral morphology, growth and development is more complex than previously thought.

  1. Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice.

    Science.gov (United States)

    Merentie, Mari; Lipponen, Jukka A; Hedman, Marja; Hedman, Antti; Hartikainen, Juha; Huusko, Jenni; Lottonen-Raikaslehto, Line; Parviainen, Viktor; Laidinen, Svetlana; Karjalainen, Pasi A; Ylä-Herttuala, Seppo

    2015-12-01

    Mouse models are extremely important in studying cardiac pathologies and related electrophysiology, but very few mouse ECG analysis programs are readily available. Therefore, a mouse ECG analysis algorithm was developed and validated. Surface ECG (lead II) was acquired during transthoracic echocardiography from C57Bl/6J mice under isoflurane anesthesia. The effect of aging was studied in young (2-3 months), middle-aged (14 months) and old (20-24 months) mice. The ECG changes associated with pharmacological interventions and common cardiac pathologies, that is, acute myocardial infarction (AMI) and progressive left ventricular hypertrophy (LVH), were studied. The ECG raw data were analyzed with an in-house ECG analysis program, modified specially for mouse ECG. Aging led to increases in P-wave duration, atrioventricular conduction time (PQ interval), and intraventricular conduction time (QRS complex width), while the R-wave amplitude decreased. In addition, the prevalence of arrhythmias increased during aging. Anticholinergic atropine shortened PQ time, and beta blocker metoprolol and calcium-channel blocker verapamil increased PQ interval and decreased heart rate. The ECG changes after AMI included early JT elevation, development of Q waves, decreased R-wave amplitude, and later changes in JT/T segment. In progressive LVH model, QRS complex width was increased at 2 and especially 4 weeks timepoint, and also repolarization abnormalities were seen. Aging, drugs, AMI, and LVH led to similar ECG changes in mice as seen in humans, which could be reliably detected with this new algorithm. The developed method will be very useful for studies on cardiovascular diseases in mice. PMID:26660552

  2. Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice

    OpenAIRE

    Merentie, Mari; Jukka A Lipponen; Hedman, Marja; Hedman, Antti; Hartikainen, Juha; Huusko, Jenni; Lottonen‐Raikaslehto, Line; Parviainen, Viktor; Laidinen, Svetlana; KARJALAINEN, Pasi A.; Ylä‐Herttuala, Seppo

    2015-01-01

    Abstract Mouse models are extremely important in studying cardiac pathologies and related electrophysiology, but very few mouse ECG analysis programs are readily available. Therefore, a mouse ECG analysis algorithm was developed and validated. Surface ECG (lead II) was acquired during transthoracic echocardiography from C57Bl/6J mice under isoflurane anesthesia. The effect of aging was studied in young (2–3 months), middle‐aged (14 months) and old (20–24 months) mice. The ECG changes associat...

  3. Factors affecting UV-B-induced changes in Arabidopsis thaliana L. gene expression: The role of development, protective pigments and the chloroplast signal

    International Nuclear Information System (INIS)

    Gene expression is known to change in response to UV-B radiation. In this paper, we have investigated three factors in Arabidopsis leaves that are likely to influence these changes: development, protective pigments and the 'chloroplast signal'. During late leaf development the major change in pigment composition, after exposure to UV-B radiation, is an increase in UV-absorbing pigments. Chl and Chl a/b ratio do not change substantially. Similarly Chl fluorescence is not altered. In contrast, RNA transcripts of photosynthetic proteins are reduced more in older leaves than in young leaves. To determine the role of flavonoids in UV-B protection, plants of Arabidopsis mutant tt-5, which have reduced flavonoids and sinapic esters, were exposed to UV-B and RNA transcript levels determined. The tt-mutants were more sensitive to UV-B radiation than wild-type. To examine the role of the chloroplast signal in regulating UV-B induced changes in gene expression, Arabidopsis gun mutants (genome uncoupled) have been used. The results show that UV-B-induced down-regulation still takes place in gun mutants and strongly suggests that the chloroplast signal is not required. Overall, this study clearly demonstrates that UV-B-induced changes in gene expression are influenced by both developmental and cellular factors but not chloroplastic factors

  4. Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.

    Science.gov (United States)

    Witteveen, Josefine S; Willemsen, Marjolein H; Dombroski, Thaís C D; van Bakel, Nick H M; Nillesen, Willy M; van Hulten, Josephus A; Jansen, Eric J R; Verkaik, Dave; Veenstra-Knol, Hermine E; van Ravenswaaij-Arts, Conny M A; Wassink-Ruiter, Jolien S Klein; Vincent, Marie; David, Albert; Le Caignec, Cedric; Schieving, Jolanda; Gilissen, Christian; Foulds, Nicola; Rump, Patrick; Strom, Tim; Cremer, Kirsten; Zink, Alexander M; Engels, Hartmut; de Munnik, Sonja A; Visser, Jasper E; Brunner, Han G; Martens, Gerard J M; Pfundt, Rolph; Kleefstra, Tjitske; Kolk, Sharon M

    2016-08-01

    Numerous genes are associated with neurodevelopmental disorders such as intellectual disability and autism spectrum disorder (ASD), but their dysfunction is often poorly characterized. Here we identified dominant mutations in the gene encoding the transcriptional repressor and MeCP2 interactor switch-insensitive 3 family member A (SIN3A; chromosome 15q24.2) in individuals who, in addition to mild intellectual disability and ASD, share striking features, including facial dysmorphisms, microcephaly and short stature. This phenotype is highly related to that of individuals with atypical 15q24 microdeletions, linking SIN3A to this microdeletion syndrome. Brain magnetic resonance imaging showed subtle abnormalities, including corpus callosum hypoplasia and ventriculomegaly. Intriguingly, in vivo functional knockdown of Sin3a led to reduced cortical neurogenesis, altered neuronal identity and aberrant corticocortical projections in the developing mouse brain. Together, our data establish that haploinsufficiency of SIN3A is associated with mild syndromic intellectual disability and that SIN3A can be considered to be a key transcriptional regulator of cortical brain development. PMID:27399968

  5. Does Exurban Housing Development Affect the Physiological Condition of Forest-Breeding Songbirds? A Case Study of Ovenbirds (Seiurus aurocapillus) in the Largest Protected Area in the Contiguous United States.

    Science.gov (United States)

    Seewagen, Chad L; Glennon, Michale; Smith, Susan B

    2015-01-01

    Exurban development (low-density development in rural areas) can significantly alter wildlife community composition, but it is largely unknown whether it also affects wildlife at the individual level. We investigated individual-level impacts of exurban development in New York State's Adirondack Park by comparing the physiological condition of 62 male ovenbirds (Seiurus aurocapillus) breeding in forests with low-density housing development with those in contiguous forests. We used hematocrit (HCT) volume and plasma triglyceride (TRIG) levels to compare energetic condition, plasma uric acid (UA) and total plasma protein (TPP) levels to compare diet quality, and heterophil∶lymphocyte ratios (H∶L) to compare chronic stress. HCT was the only parameter to differ, with birds near houses exhibiting lower values. The comparable TRIG, UA, and TPP that we found between treatment types suggest that ovenbird food quality and availability are unaffected by exurban development in our study area. Similar H∶L suggests that homeowner activities do not significantly change chronic stressors faced by breeding male ovenbirds. We also found no difference in body mass, body size, or age ratio to indicate that habitats in either treatment type were in higher demand or more difficult to acquire. Although our results suggest that exurban development does not reduce habitat quality for male ovenbirds in a way that affects their condition, we caution that it may still ultimately reduce fitness by attracting synanthropic predators. Further work is needed to better understand the impacts of exurban development on wildlife at all levels and provide science-based information needed to meet conservation challenges in rapidly developing exurban areas. PMID:26052638

  6. Activation tagging of the LEAFY PETIOLE gene affects leaf petiole development in Arabidopsis thaliana

    DEFF Research Database (Denmark)

    van der Graaff, Eric; Dulk-Ras, A D; Hooykaas, P J;

    2000-01-01

    In a screen for leaf developmental mutants we have isolated an activator T-DNA-tagged mutant that produces leaves without a petiole. In addition to that leafy petiole phenotype this lettuce (let) mutant shows aberrant inflorescence branching and silique shape. The LEAFY PETIOLE (LEP) gene is...... located close to the right border of the T-DNA insert linked with these dominant phenotypes and encodes a protein with a domain with similarity to the DNA binding domain of members of the AP2/EREBP family of transcription factors. Introduction of the activation-tagged LEP gene in wild-type plants...... conferred all the phenotypic aberrations mentioned above. The leafy petiole phenotype consists of a conversion of the proximal part of the leaf from petiole into leaf blade, which means that leaf development in let is disturbed along the proximodistal axis. Therefore, LEP is involved in either cell division...

  7. ENU mutagenesis reveals that Notchless homolog 1 (Drosophila affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development

    Directory of Open Access Journals (Sweden)

    Lossie Amy C

    2012-12-01

    Full Text Available Abstract Background Our interests lie in determining the genes and genetic pathways that are important for establishing and maintaining maternal-fetal interactions during pregnancy. Mutation analysis targeted to a 34 Mb domain flanked by Trp53 and Wnt3 demonstrates that this region of mouse chromosome 11 contains a large number of essential genes. Two mutant alleles (l11Jus1 and l11Jus4, which fall into the same complementation group, survive through implantation but fail prior to gastrulation. Results Through a positional cloning strategy, we discovered that these homozygous mutant alleles contain non-conservative missense mutations in the Notchless homolog 1 (Drosophila (Nle1 gene. NLE1 is a member of the large WD40-repeat protein family, and is thought to signal via the canonical NOTCH pathway in vertebrates. However, the phenotype of the Nle1 mutant mice is much more severe than single Notch receptor mutations or even in animals in which NOTCH signaling is blocked. To test the hypothesis that NLE1 functions in multiple signaling pathways during pre-implantation development, we examined expression of multiple Notch downstream target genes, as well as select members of the Wnt pathway in wild-type and mutant embryos. We did not detect altered expression of any primary members of the Notch pathway or in Notch downstream target genes. However, our data reveal that Cdkn1a, a NOTCH target, was upregulated in Nle1 mutants, while several members of the Wnt pathway are downregulated. In addition, we found that Nle1 mutant embryos undergo caspase-mediated apoptosis as hatched blastocysts, but not as morulae or blastocysts. Conclusions Taken together, these results uncover potential novel functions for NLE1 in the WNT and CDKN1A pathways during embryonic development in mammals.

  8. Growth and development indicators in children from nearest areas affected by the Chernobyl accident attended in Cuba between 1990 to 1992

    International Nuclear Information System (INIS)

    The work values indicators of growth and development in 3121 children of 421 Ukrainian regions, classifying them and relating their weights and heights with the age, sex and density of superficial pollution with Cs-137, of the grounds where inhabit. Depending on the levels of density of superficial pollution (kBq/m2) were established the following groups: 185 emptied and unknown. Weight and height values were increased in both sexes in direct relationship with age, although superior for the males resulted in almost all ages except in the of 10-15 years in that the females prevail. Middle values of weight and height do not modify significantly with the levels of pollution density, although these values are increased for ages of 0-5 10-15 years in both sexes, for the levels of high density of superficial pollution, without that manage to constitute a tendency. While in the ages of 5-10 years have their high value of weight in the group 2 of density of superficial pollution and of height for the group 3 in both sexes. (authors). 3 refs., 5 tabs

  9. Analysis of the factors affecting women's football reserve personnel development%影响女足后备人才发展的因素分析

    Institute of Scientific and Technical Information of China (English)

    张哲

    2013-01-01

    Based on the impact factors of China women's football reserve personnel training as the research object, using literature method, questionnaire method, interview method, logic analysis method, discusses the influence factors of athletes, women's football reserve talented person coaches factors, educational factors, management factors, training factors, competition factors, funding factors, in order to provide theoretical basis for promoting the development of the Chinese women's football reserve talent.%  以我国女足后备人才培养的影响因素为研究对象,采用文献法、问卷调查法、访谈法、逻辑分析法等,探讨了影响女足后备人才成才的运动员因素、教练员因素、文化教育因素、管理因素、训练因素、竞赛因素、经费投入等问题,旨在为促进我国女足后备人才的发展提供理论依据。

  10. Water-related Issues Affecting Conventional Oil and Gas Recovery and Potential Oil-Shale Development in the Uinta Basin, Utah

    Energy Technology Data Exchange (ETDEWEB)

    Berg, Michael Vanden; Anderson, Paul; Wallace, Janae; Morgan, Craig; Carney, Stephanie

    2012-04-30

    in the subsurface of the Uinta Basin using a combination of water chemistry data collected from various sources and by analyzing geophysical well logs. By re-mapping the base of the moderately saline aquifer using more robust data and more sophisticated computer-based mapping techniques, regulators now have the information needed to more expeditiously grant water disposal permits while still protecting freshwater resources. Part 2: Eastern Uinta Basin gas producers have identified the Birds Nest aquifer, located in the Parachute Creek Member of the Green River Formation, as the most promising reservoir suitable for large-volume saline water disposal. This aquifer formed from the dissolution of saline minerals that left behind large open cavities and fractured rock. This new and complete understanding the aquifer?s areal extent, thickness, water chemistry, and relationship to Utah?s vast oil shale resource will help operators and regulators determine safe saline water disposal practices, directly impacting the success of increased hydrocarbon production in the region, while protecting potential future oil shale production. Part 3: In order to establish a baseline of water quality on lands identified by the U.S. Bureau of Land Management as having oil shale development potential in the southeastern Uinta Basin, the UGS collected biannual water samples over a three-year period from near-surface aquifers and surface sites. The near-surface and relatively shallow groundwater quality information will help in the development of environmentally sound water-management solutions for a possible future oil shale and oil sands industry and help assess the sensitivity of the alluvial and near-surface bedrock aquifers. This multifaceted study will provide a better understanding of the aquifers in Utah?s Uinta Basin, giving regulators the tools needed to protect precious freshwater resources while still allowing for increased hydrocarbon production.

  11. Analysis of non-methane hydrocarbon data from a monitoring station affected by oil and gas development in the Eagle Ford shale, Texas

    Directory of Open Access Journals (Sweden)

    Gunnar W. Schade

    2016-03-01

    Full Text Available Abstract Within the last decade, unconventional oil and gas exploration in the US has become a new source of atmospheric hydrocarbons. Although a geographically dispersed source, field measurements in and downwind of a number of shale basins demonstrate the impact exploration activities have on ambient levels of hydrocarbons. Due to concerns related to ozone production, regulatory agencies are adding monitoring stations to better understand the potential influence of emissions from areas with increased oil and gas related activities. The Eagle Ford shale in south Texas is a rapidly developing shale play producing both oil and natural gas, providing 10% and 5% of US domestic oil and gas production, respectively, in 2013. We analyzed the first year of measurements from a newly established monitoring site at its central north edge. The data reveal median ethane mixing ratios—used as a marker for oil and gas exploration related emissions—at five times its typical clean air background. Ethane mixing ratios above ten times the background occurred regularly. Saturated hydrocarbons with likely origin in oil and gas exploration explain half of the data set’s variability. They dominate OH radical reactivity at levels both similar to other shale areas and similar to Houston’s ship channel area a decade ago. Air advecting slowly across the shale area from east-southeast and southwest directions shows the most elevated hydrocarbon concentrations, and evidence is presented linking elevated alkene abundances to flaring in the shale area. A case study is presented linking high emissions from an upwind facility to hydrocarbon plumes observed at the monitor.

  12. A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-alpha in obese Zucker rats.

    Science.gov (United States)

    Galisteo, Milagros; Sánchez, Manuel; Vera, Rocío; González, Mercedes; Anguera, Anna; Duarte, Juan; Zarzuelo, Antonio

    2005-10-01

    The aim of the present study was to analyze whether consumption of a fiber-supplemented diet containing 3.5% Plantago ovata husks prevented many of the abnormalities clustered in the metabolic syndrome, including obesity, dyslipidemia, hypertension and endothelial dysfunction. For this purpose, obese Zucker rats, a model of type 2 diabetes, and their lean littermates were studied. Rats consumed a standard control diet or that diet supplemented with 3.5% P. ovata husks for 25 wk. Body weights were measured weekly. Systolic blood pressure (SBP) was measured monthly. At the end of the treatment, plasma concentrations of triglycerides, total cholesterol, FFAs, glucose, insulin, adiponectin, and tumor necrosis factor alpha (TNF-alpha) were determined, and studies on vascular function were performed using aortic rings. Rats fed the P. ovata husk-supplemented diet had a significantly reduced body weight gain compared with those fed the standard diet. Decreased endothelium-dependent relaxation in response to acetylcholine (ACh) by aortic rings from obese Zucker rats was improved in those fed the fiber-supplemented diet. The greater SBP, higher plasma concentrations of triglycerides, total cholesterol, FFA, glucose, insulin, and TNF-alpha, and the hypoadinectinemia that occurred in obese Zucker rats that consumed the control diet were significantly improved in those fed the fiber-supplemented diet. We conclude that intake of a P. ovata husk-supplemented diet prevents endothelial dysfunction, hypertension, and obesity development, and ameliorates dyslipidemia and abnormal plasma concentrations of adiponectin and TNF-alpha in obese Zucker rats. PMID:16177203

  13. An a priori analysis of how solar energy production will affect the balance of payment account in one developing Latin American country

    Energy Technology Data Exchange (ETDEWEB)

    Stavy, Michael [Chicago, Illinois (United States)

    2000-07-01

    This paper studies a model developing Latin American country (hypotheria) with a weak currency (the hypo is the monetary unit), a trade deficit (including being a net importer of fossil fuels) and a sensitive balance of payments situation. There is an a priori analysis of the effect of domestic solar energy production on Hypotheria's positive effect is the BoP Value of domestic solar energy. Many forms of solar energy are not cost competitive with fossil fuels. Because solar energy production does not emit greenhouse Value and the BoP Value of solar energy should be used to reduce the cost of solar energy projects in Hypotheria and to make the solar energy cost competitive with fossil fuels. [Spanish] Este articulo estudia un modelo de un pais Latinoamericano en desarrollo (Hypoteria) con moneda debil (el hypo es la unidad monetaria), un deficit comercial (incluyendo el ser un importador neto de combustibles fosiles) y un balance precario en la situacion de pagos. Existe un analisis a priori sobre el efecto de la produccion domestica de energia solar en un efecto positivo de Hypoteria que es el Valor de la Balanza de Pagos (BoP) de la energia solar domestica. Muchas formas de energia solar no son competitivas en costo con los combustibles fosiles debido a que la produccion de energia solar no emite un Valor de invernadero, y el Valor de la Balanza de Pagos, debe ser utilizado para reducir los costos de los proyectos de energia solar en Hypoteria y asi hacer el costo de la energia solar competitiva con los combustibles fosiles.

  14. Conjugated linoleic acid (CLA versus saturated fats/cholesterol: their proportion in fatty and lean meats may affect the risk of developing colon cancer

    Directory of Open Access Journals (Sweden)

    Lopez Cristina B

    2003-08-01

    Full Text Available Abstract In spite of the considerable amount of experimental, clinical and epidemiological research about the consumption of red meat, total fats, saturated/unsaturated fatty acids and cholesterol with regard to the risk of developing colorectal cancer (CRC, the issue remains controversial. The general belief is a reduction of red meat intake, and subsequent nutritional advice usually strongly recommends this. Paradoxically, beef together with whole milk and dairy derivatives, are almost the only sources for conjugated linoleic acid (CLAs family. Furthermore CLAs are the only natural fatty acids accepted by the National Academy of Sciences of USA as exhibiting consistent antitumor properties at levels as low as 0.25 – 1.0 per cent of total fats. Beside CLA, other polyunsaturated fatty acids (PUFA belonging to the essential fatty acid (EFA n-3 family, whose main source are fish and seafood, are generally believed to be antipromoters for several cancers. The purpose of this work is to critically analyze the epidemiological and experimental evidence by tentatively assuming that the reciprocal proportions of saturated fats (SA plus cholesterol (CH versus CLAs levels in fatty or lean beef may play an antagonistic role underlying the contradictory effects reported for red meats consumption and CRC risk. Recent results about meat intake and risk for CRC in Argentina have shown an unexpected dual behaviour related to the type of meats. Fatty meat derivatives, such as cold cuts and sausages, mainly prepared from fatty beef (up to 37% fat were associated with higher risk, whereas high consumption of lean beef (

  15. Mood swings: design and evaluation of affective interactive art

    NARCIS (Netherlands)

    Bialoskorski, Leticia S.S.; Westerink, Joyce H.D.M.; Broek, van den Egon L.

    2009-01-01

    The field of affective computing is concerned with developing emphatic products, such as affective consumer products, affective games, and affective art. This paper describes Mood Swings, an affective interactive art system, which interprets and visualizes affect expressed by a person. Mood Swings c

  16. DEVELOPMENT OF FRASTA SIMULATION SOFTWARE

    Institute of Scientific and Technical Information of China (English)

    Y.G. Cao; K. Tanaka

    2006-01-01

    Fracture-surface topography analysis ( FRASTA ) was successfully used to simulate the process of crack and calculate parameters of crack such as the crack opening angle (COA) and crack-tip opening angle (CTOA). But because the amount of calculation is large, errors are often made during the course of calculation. FRASTA simulation software, namely fracture surface analyst (FSA) is developed and a series of center-cracked tension (CCT) and double edge notched (DEN)specimens of different materials with different sizes are tested, their fracture surfaces are scanned by non-contact 3D scanning system and the elevation data of the fracture surfaces is recorded.FSA used the recorded elevation data of fracture surfaces to simulate the process of crack based on the principle of FRASTA. Results show that FSA can accurately simulate the process and calculate the parameters of crack.

  17. Evaluation of Heat-affected Zone Hydrogen-induced Cracking in High-strength Steels

    Science.gov (United States)

    Yue, Xin

    Shipbuilding is heavily reliant on welding as a primary fabrication technique. Any high performance naval steel must also possess good weldability. It is therefore of great practical importance to conduct weldability testing of naval steels. Among various weldability issues of high-strength steels, hydrogen-induced cracking (HIC) in the heat-affected zone (HAZ) following welding is one of the biggest concerns. As a result, in the present work, research was conducted to study the HAZ HIC susceptibility of several naval steels. Since the coarse-grained heat-affected zone (CGHAZ) is generally known to be the most susceptible to HIC in the HAZ region, the continuous cooling transformation (CCT) behavior of the CGHAZ of naval steels HSLA-65, HSLA-100, and HY-100 was investigated. The CGHAZ microstructure over a range of cooling rates was characterized, and corresponding CCT diagrams were constructed. It was found that depending on the cooling rate, martensite, bainite, ferrite and pearlite can form in the CGHAZ of HSLA-65. For HSLA-100 and HY-100, only martensite and bainite formed over the range of cooling rates that were simulated. The constructed CCT diagrams can be used as a reference to select welding parameters to avoid the formation of high-hardness martensite in the CGHAZ, in order to ensure resistance to hydrogen-induced cracking. Implant testing was conducted on the naval steels to evaluate their susceptibility to HAZ HIC. Stress vs. time to failure curves were plotted, and the lower critical stress (LCS), normalized critical stress ratio (NCSR) and embrittlement index (EI) for each steel were determined, which were used to quantitatively compare HIC susceptibility. The CGHAZ microstructure of the naval steels was characterized, and the HIC fracture behavior was studied. Intergranular (IG), quasi-cleavage (QC) and microvoid coalescence (MVC) fracture modes were found to occur in sequence during the crack initiation and propagation process. This was

  18. Affect and Metaphor Sensing in Virtual Drama

    OpenAIRE

    Li Zhang; John Barnden

    2010-01-01

    We report our developments on metaphor and affect sensing for several metaphorical language phenomena including affects as external entities metaphor, food metaphor, animal metaphor, size metaphor, and anger metaphor. The metaphor and affect sensing component has been embedded in a conversational intelligent agent interacting with human users under loose scenarios. Evaluation for the detection of several metaphorical language phenomena and affect is provided. Our paper contributes to the jour...

  19. The affect structure revisited

    OpenAIRE

    Elefant-Yanni, Véronique Rica; Victoria-Feser, Maria-Pia

    2005-01-01

    In affective psychology, there is a persistent controversy about the number, the nature and the definition of the affect structure dimensions. Responding to the methodological criticisms addressed to the preceding studies, we conciliated the principal theories regarding the affect structure with the same experimental setting. In particular, using the semantic items all around the circumplex we found three bipolar independent dimensions and using only the PANAS semantic items, we found two uni...

  20. Public beliefs that may affect biomass development

    International Nuclear Information System (INIS)

    The Tennessee River chip mill controversy involves the expansion of the pulp and paper industry rather than the biomass energy industry; however, the concerns expressed by environmentalists are likely to be the same for biomass projects that propose use of privately-owned land. It may be incorrect to assume that private landowners will have more flexibility in forest management techniques than public agencies. In fact, when faced with a potentially large new demand source for wood, environmentalists will try to stop the project while pushing for stringent regulation of harvesting. This paper describes and analyzes beliefs about forest management (related to biomass energy) taken from the 1,200 letters and 200 public hearing statements received by TVA on the chip mill environmental impact statement. The chip mill controversy suggests that there is a potential for strong coalitions to form to stop new biomass demand sources. As much as possible, the biomass industry will need to anticipate and address land management issues. New concepts such as landscape ecology and ecosystem management should be considered. Even so, increased use of non-dedicated biomass resources will require more public acceptance of the concept that ecosystems and their biomass resources can tolerate increased levels of management